Rotary wave-ejector enhanced pulse detonation engine

Science.gov (United States)

Nalim, M. R.; Izzy, Z. A.; Akbari, P.

2012-01-01

The use of a non-steady ejector based on wave rotor technology is modeled for pulse detonation engine performance improvement and for compatibility with turbomachinery components in hybrid propulsion systems. The rotary wave ejector device integrates a pulse detonation process with an efficient momentum transfer process in specially shaped channels of a single wave-rotor component. In this paper, a quasi-one-dimensional numerical model is developed to help design the basic geometry and operating parameters of the device. The unsteady combustion and flow processes are simulated and compared with a baseline PDE without ejector enhancement. A preliminary performance assessment is presented for the wave ejector configuration, considering the effect of key geometric parameters, which are selected for high specific impulse. It is shown that the rotary wave ejector concept has significant potential for thrust augmentation relative to a basic pulse detonation engine.

Visible continuum pulses based on enhanced dispersive wave generation for endogenous fluorescence imaging.

Science.gov (United States)

Cui, Quan; Chen, Zhongyun; Liu, Qian; Zhang, Zhihong; Luo, Qingming; Fu, Ling

2017-09-01

In this study, we demonstrate endogenous fluorescence imaging using visible continuum pulses based on 100-fs Ti:sapphire oscillator and a nonlinear photonic crystal fiber. Broadband (500-700 nm) and high-power (150 mW) continuum pulses are generated through enhanced dispersive wave generation by pumping femtosecond pulses at the anomalous dispersion region near zero-dispersion wavelength of high-nonlinear photonic crystal fibers. We also minimize the continuum pulse width by determining the proper fiber length. The visible-wavelength two-photon microscopy produces NADH and tryptophan images of mice tissues simultaneously. Our 500-700 nm continuum pulses support extending nonlinear microscopy to visible wavelength range that is inaccessible to 100-fs Ti:sapphire oscillators and other applications requiring visible laser pulses.

Estimated carotid-femoral pulse wave velocity has similar predictive value as measured carotid-femoral pulse wave velocity

DEFF Research Database (Denmark)

Greve, Sara V; Blicher, Marie K; Kruger, Ruan

2016-01-01

BACKGROUND: Carotid-femoral pulse wave velocity (cfPWV) adds significantly to traditional cardiovascular risk prediction, but is not widely available. Therefore, it would be helpful if cfPWV could be replaced by an estimated carotid-femoral pulse wave velocity (ePWV) using age and mean blood pres...... that these traditional risk scores have underestimated the complicated impact of age and blood pressure on arterial stiffness and cardiovascular risk....

The Diagnostic Value of Pulsed Wave Tissue Doppler Imaging in Asymptomatic Beta- Thalassemia Major Children and Young Adults; Relation to Chemical Biomarkers of Left Ventricular Function and Iron Overload.

Science.gov (United States)

Ragab, Seham M; Fathy, Waleed M; El-Aziz, Walaa FAbd; Helal, Rasha T

2015-01-01

Cardiac iron toxicity is the leading cause of death among β-halassaemia major (TM) patients. Once heart failure becomes overt, it is difficult to reverse. To investigate non-overt cardiac dysfunctions in TM patients using pulsed wave Tissue Doppler Imaging (TD I) and its relation to iron overload and brain natriuretic peptide (BNP). Thorough clinical, conventional echo and pulsed wave TDI parameters were compared between asymptomatic 25 β-TM patients and 20 age and gender matched individuals. Serum ferritin and plasma BNP levels were assayed by ELISA. TM patients had significant higher mitral inflow early diastolic (E) wave and non significant other conventional echo parameters. In the patient group, pulsed wave TDI revealed systolic dysfunctions, in the form of significant higher isovolumetric contraction time (ICT), and lower ejection time (E T), with diastolic dysfunction in the form of higher isovolumetric relaxation time (IRT), and lower mitral annulus early diastolic velocity E' (12.07 ±2.06 vs 15.04±2.65, P= 0.003) compared to the controls. Plasma BNP was higher in patients compared to the controls. Plasma BNP and serum ferritin had a significant correlation with each other and with pulsed wave conventional and TDI indices of systolic and diastolic functions. Patients with E/E' ≥ 8 had significant higher serum ferritin and plasma BNP levels compared to those with ratio wave TDI is an important diagnostic tool for latent cardiac dysfunction in iron-loaded TM patients and is related to iron overload and BNP.

Compact biomedical pulsed signal generator for bone tissue stimulation

Science.gov (United States)

Kronberg, James W.

1993-01-01

An apparatus for stimulating bone tissue for stimulating bone growth or treating osteoporosis by applying directly to the skin of the patient an alternating current electrical signal comprising wave forms known to simulate the piezoelectric constituents in bone. The apparatus may, by moving a switch, stimulate bone growth or treat osteoporosis, as desired. Based on low-power CMOS technology and enclosed in a moisture-resistant case shaped to fit comfortably, two astable multivibrators produce the desired waveforms. The amplitude, pulse width and pulse frequency, and the subpulse width and subpulse frequency of the waveforms are adjustable. The apparatus, preferably powered by a standard 9-volt battery, includes signal amplitude sensors and warning signals indicate an output is being produced and the battery needs to be replaced.

THE DIAGNOSTIC VALUE OF PULSED WAVE TISSUE DOPPLER IMAGING IN ASYMPTOMATIC BETA- THALASSEMIA MAJOR CHILDREN AND YOUNG ADULTS ; RELATION TO CHEMICAL BIOMARKERS OF LEFT VENTRICULAR FUNCTION AND IRON OVERLOAD .

Directory of Open Access Journals (Sweden)

Seham Ragab

2015-08-01

Full Text Available Background: Cardiac iron toxicity is the leading cause of death among  β-halassaemia major (TM  patients.  Once  heart failure becomes overt , it will be  difficult to reverse . Objectives: To investigate non overt cardiac dysfunctions  in TM patients using  pulsed wave Tissue Doppler  Imaging (TD I and its relation to the iron overload and brain natruritic peptide (BNP. Methods: Thorough  clinical , conventional echo and  pulsed  wave TDI  parameters were compared between  asymtomatic 25 β-TM  patients  and 20 age and gender matched individuals. Serum ferritin and plasma BNP  levels were assayed by  ELISA .  Results: TM patients had significant higher mitral inflow early diastolic (E wave and  non significant other conventional echo  parameters. Pulsed wave TDI revealed systolic and diastolic dysfunctions in the form of significant higher  isovolumetric contraction time (ICT , ejection time ( E T and  isovolumetric relaxation time (IRT with significantly lower  mitral annulus  early diastolic velocity E` (12.07 ±2.06 vs 15.04±2.65 ,P= 0.003  in patients compared to  controls. Plasma BNP was higher in patients compared to the controls.  Plasma BNP and serum ferritin had significant correlation with each other and with pulsed wave conventional and TDI indices of systolic and diastolic functions.  Patients with E/E` ≥ 8 had  significant higher  serum ferritin  and plasma BNP levels compared to those with E/E` ratio < 8 without difference in Hb levels .Conclusion:  Pulsed wave TDI  is an  important diagnostic tool for latent cardiac dysfunction in iron loaded TM patients and is related to iron overload and BNP .

Pulse-wave propagation in straight-geometry vessels for stiffness estimation: theory, simulations, phantoms and in vitro findings.

Science.gov (United States)

Shahmirzadi, Danial; Li, Ronny X; Konofagou, Elisa E

2012-11-01

Pulse wave imaging (PWI) is an ultrasound-based method for noninvasive characterization of arterial stiffness based on pulse wave propagation. Reliable numerical models of pulse wave propagation in normal and pathological aortas could serve as powerful tools for local pulse wave analysis and a guideline for PWI measurements in vivo. The objectives of this paper are to (1) apply a fluid-structure interaction (FSI) simulation of a straight-geometry aorta to confirm the Moens-Korteweg relationship between the pulse wave velocity (PWV) and the wall modulus, and (2) validate the simulation findings against phantom and in vitro results. PWI depicted and tracked the pulse wave propagation along the abdominal wall of canine aorta in vitro in sequential Radio-Frequency (RF) ultrasound frames and estimates the PWV in the imaged wall. The same system was also used to image multiple polyacrylamide phantoms, mimicking the canine measurements as well as modeling softer and stiffer walls. Finally, the model parameters from the canine and phantom studies were used to perform 3D two-way coupled FSI simulations of pulse wave propagation and estimate the PWV. The simulation results were found to correlate well with the corresponding Moens-Korteweg equation. A high linear correlation was also established between PWV² and E measurements using the combined simulation and experimental findings (R² =  0.98) confirming the relationship established by the aforementioned equation.

Estimated carotid-femoral pulse wave velocity has similar predictive value as measured carotid-femoral pulse wave velocity

DEFF Research Database (Denmark)

Olsen, Michael; Greve, Sara; Blicher, Marie

2016-01-01

OBJECTIVE: Carotid-femoral pulse wave velocity (cfPWV) adds significantly to traditional cardiovascular (CV) risk prediction, but is not widely available. Therefore, it would be helpful if cfPWV could be replaced by an estimated carotid-femoral pulse wave velocity (ePWV) using age and mean blood...... pressure and previously published equations. The aim of this study was to investigate whether ePWV could predict CV events independently of traditional cardiovascular risk factors and/or cfPWV. DESIGN AND METHOD: cfPWV was measured and ePWV calculated in 2366 apparently healthy subjects from four age...

Multiple pulse traveling wave excitation of neon-like germanium

International Nuclear Information System (INIS)

Moreno, J. C.; Nilsen, J.; Silva, L. B. da

1995-01-01

Traveling wave excitation has been shown to significantly increase the output intensity of the neon-like germanium x-ray laser. The driving laser pulse consisted of three 100 ps Gaussian laser pulses separated by 400 ps. Traveling wave excitation was employed by tilting the wave front of the driving laser by 45 degrees to match the propagation speed of the x-ray laser photons along the length of the target. We show results of experiments with the traveling wave, with no traveling wave, and against the traveling wave and comparisons to a numerical model. Gain was inferred from line intensity measurements at two lengths

Modelling far field pacing for terminating spiral waves pinned to ischaemic heterogeneities in cardiac tissue

Science.gov (United States)

Boccia, E.; Luther, S.

2017-01-01

In cardiac tissue, electrical spiral waves pinned to a heterogeneity can be unpinned (and eventually terminated) using electric far field pulses and recruiting the heterogeneity as a virtual electrode. While for isotropic media the process of unpinning is much better understood, the case of an anisotropic substrate with different conductivities in different directions still needs intensive investigation. To study the impact of anisotropy on the unpinning process, we present numerical simulations based on the bidomain formulation of the phase I of the Luo and Rudy action potential model modified due to the occurrence of acute myocardial ischaemia. Simulating a rotating spiral wave pinned to an ischaemic heterogeneity, we compare the success of sequences of far field pulses in the isotropic and the anisotropic case for spirals still in transient or in steady rotation states. Our results clearly indicate that the range of pacing parameters resulting in successful termination of pinned spiral waves is larger in anisotropic tissue than in an isotropic medium. This article is part of the themed issue ‘Mathematical methods in medicine: neuroscience, cardiology and pathology’. PMID:28507234

Wave fronts, pulses and wave trains in photoexcited superlattices behaving as excitable or oscillatory media

International Nuclear Information System (INIS)

Arana, J I; Bonilla, L L; Grahn, H T

2011-01-01

Undoped and strongly photoexcited semiconductor superlattices with field-dependent recombination behave as excitable or oscillatory media with spatially discrete nonlinear convection and diffusion. Infinitely long, dc-current-biased superlattices behaving as excitable media exhibit wave fronts with increasing or decreasing profiles, whose velocities can be calculated by means of asymptotic methods. These superlattices can also support pulses of the electric field. Pulses moving downstream with the flux of electrons can be constructed from their component wave fronts, whereas pulses advancing upstream do so slowly and experience saltatory motion: they change slowly in long intervals of time separated by fast transitions during which the pulses jump to the previous superlattice period. Photoexcited superlattices can also behave as oscillatory media and exhibit wave trains. (paper)

Photodisruption in biological tissues using femtosecond laser pulses

Science.gov (United States)

Shen, Nan

Transparent materials do not ordinarily absorb visible or near-infrared light. However, the intensity of a tightly focused femtosecond laser pulse is great enough that nonlinear absorption of the laser energy takes place in transparent materials, leading to optical breakdown and permanent material modification. Because the absorption process is nonlinear, absorption and material modification are confined to the extremely small focal volume. Optical breakdown in transparent or semi-transparent biological tissues depends on intensity rather than energy. As a result, focused femtosecond pulses induce optical breakdown with significantly less pulse energy than is required with longer pulses. The use of femtosecond pulses therefore minimizes the amount of energy deposited into the targeted region of the sample, minimizing mechanical and thermal effects that lead to collateral damage in adjacent tissues. We demonstrate photodisruptive surgery in animal skin tissue and single cells using 100-fs laser pulses. In mouse skin, we create surface incisions and subsurface cavities with much less collateral damage to the surrounding tissue than is produced with picosecond pulses. Using pulses with only a few nanojoules of energy obtained from an unamplified femtosecond oscillator, we destroy single mitochondria in live cells without affecting cell viability, providing insights into the structure of the mitochondrial network. An apparatus is constructed to perform subcellular surgery and multiphoton 3D laser scanning imaging simultaneously with a single laser and objective lens.

Pulse Wave Variation during the Menstrual Cycle in Women with Menstrual Pain

Directory of Open Access Journals (Sweden)

Soo Hyung Jeon

2016-01-01

Full Text Available Objective. This study is performed to obtain objective diagnostic indicators associated with menstrual pain using pulse wave analysis. Methods. Using a pulse diagnostic device, we measured the pulse waves of 541 women aged between 19 and 30 years, placed in either an experimental group with menstrual pain (n=329 or a control group with little or no menstrual pain (n=212. Measurements were taken during both the menstrual and nonmenstrual periods, and comparative analysis was performed. Results. During the nonmenstrual period, the experimental group showed a significantly higher value in the left radial artery for the radial augmentation index (RAI (p=0.050 but significantly lower values for pulse wave energy (p=0.021 and time to first peak from baseline (T1 (p=0.035 in the right radial artery. During the menstrual period, the experimental group showed significantly lower values in the left radial artery for cardiac diastole and pulse wave area during diastole and significantly higher values for pulse wave area during systole, ratio of systolic phase to the full heartbeat, and systolic-diastolic ratio. Conclusion. We obtained indicators of menstrual pain in women during the menstrual period, including prolonged systolic and shortened diastolic phases, increases in pulse wave energy and area of representative pulse wave, and increased blood vessel resistance.

Transcranial magnetic stimulation with a half-sine wave pulse elicits direction-specific effects in human motor cortex

DEFF Research Database (Denmark)

Jung, Nikolai H; Delvendahl, Igor; Pechmann, Astrid

2012-01-01

Transcranial magnetic stimulation (TMS) commonly uses so-called monophasic pulses where the initial rapidly changing current flow is followed by a critically dampened return current. It has been shown that a monophasic TMS pulse preferentially excites different cortical circuits in the human motor...... hand area (M1-HAND), if the induced tissue current has a posterior-to-anterior (PA) or anterior-to-posterior (AP) direction. Here we tested whether similar direction-specific effects could be elicited in M1-HAND using TMS pulses with a half-sine wave configuration....

Attosecond ionization gating for isolated attosecond electron wave packet and broadband attosecond xuv pulses

International Nuclear Information System (INIS)

Lan Pengfei; Lu Peixiang; Cao Wei; Li Yuhua; Wang Xinlin

2007-01-01

An attosecond ionization gating is achieved using a few-cycle laser pulse in combination with its second harmonic. With this gating, the generation of the electron wave packet (EWP) is coherently controlled, and an isolated EWP of about 270 as is generated. An isolated broadband attosecond extreme ultraviolet pulse with a bandwidth of about 75 eV can also be generated using this gating, which can be used for EWP measurements as efficiently as a 50-as pulse, allowing one to measure a wide range of ultrafast dynamics not normally accessible before

FPGA-based design and implementation of arterial pulse wave generator using piecewise Gaussian-cosine fitting.

Science.gov (United States)

Wang, Lu; Xu, Lisheng; Zhao, Dazhe; Yao, Yang; Song, Dan

2015-04-01

Because arterial pulse waves contain vital information related to the condition of the cardiovascular system, considerable attention has been devoted to the study of pulse waves in recent years. Accurate acquisition is essential to investigate arterial pulse waves. However, at the stage of developing equipment for acquiring and analyzing arterial pulse waves, specific pulse signals may be unavailable for debugging and evaluating the system under development. To produce test signals that reflect specific physiological conditions, in this paper, an arterial pulse wave generator has been designed and implemented using a field programmable gate array (FPGA), which can produce the desired pulse waves according to the feature points set by users. To reconstruct a periodic pulse wave from the given feature points, a method known as piecewise Gaussian-cosine fitting is also proposed in this paper. Using a test database that contains four types of typical pulse waves with each type containing 25 pulse wave signals, the maximum residual error of each sampling point of the fitted pulse wave in comparison with the real pulse wave is within 8%. In addition, the function for adding baseline drift and three types of noises is integrated into the developed system because the baseline occasionally wanders, and noise needs to be added for testing the performance of the designed circuits and the analysis algorithms. The proposed arterial pulse wave generator can be considered as a special signal generator with a simple structure, low cost and compact size, which can also provide flexible solutions for many other related research purposes. Copyright © 2015 Elsevier Ltd. All rights reserved.

Coherent combining pulse bursts in time domain

Science.gov (United States)

Galvanauskas, Almantas

2018-01-09

A beam combining and pulse stacking technique is provided that enhances laser pulse energy by coherent stacking pulse bursts (i.e. non-periodic pulsed signals) in time domain. This energy enhancement is achieved by using various configurations of Fabry-Perot, Gires-Tournois and other types of resonant cavities, so that a multiple-pulse burst incident at either a single input or multiple inputs of the system produces an output with a solitary pulse, which contains the summed energy of the incident multiple pulses from all beams. This disclosure provides a substantial improvement over conventional coherent-combining methods in that it achieves very high pulse energies using a relatively small number of combined laser systems, thus providing with orders of magnitude reduction in system size, complexity, and cost compared to current combining approaches.

Thermal damage produced by high-irradiance continuous wave CO2 laser cutting of tissue.

Science.gov (United States)

Schomacker, K T; Walsh, J T; Flotte, T J; Deutsch, T F

1990-01-01

Thermal damage produced by continuous wave (cw) CO2 laser ablation of tissue in vitro was measured for irradiances ranging from 360 W/cm2 to 740 kW/cm2 in order to investigate the extent to which ablative cooling can limit tissue damage. Damage zones thinner than 100 microns were readily produced using single pulses to cut guinea pig skin as well as bovine cornea, aorta, and myocardium. Multiple pulses can lead to increased damage. However, a systematic decrease in damage with irradiance, predicted theoretically by an evaporation model of ablation, was not observed. The damage-zone thickness was approximately constant around the periphery of the cut, consistent with the existence of a liquid layer which stores heat and leads to tissue damage, and with a model of damage and ablation recently proposed by Zweig et al.

Electrochemical Oxidation by Square-Wave Potential Pulses in the Imitation of Oxidative Drug Metabolism

NARCIS (Netherlands)

Nouri-Nigjeh, Eslam; Permentier, Hjalmar P.; Bischoff, Rainer; Bruins, Andries P.

2011-01-01

Electrochemistry combined with mass spectrometry (EC-MS) is an emerging analytical technique in the imitation of oxidative drug metabolism at the early stages of new drug development. Here, we present the benefits of electrochemical oxidation by square-wave potential pulses for the oxidation of

Wave equations for pulse propagation

International Nuclear Information System (INIS)

Shore, B.W.

1987-01-01

Theoretical discussions of the propagation of pulses of laser radiation through atomic or molecular vapor rely on a number of traditional approximations for idealizing the radiation and the molecules, and for quantifying their mutual interaction by various equations of propagation (for the radiation) and excitation (for the molecules). In treating short-pulse phenomena it is essential to consider coherent excitation phenomena of the sort that is manifest in Rabi oscillations of atomic or molecular populations. Such processes are not adequately treated by rate equations for excitation nor by rate equations for radiation. As part of a more comprehensive treatment of the coupled equations that describe propagation of short pulses, this memo presents background discussion of the equations that describe the field. This memo discusses the origin, in Maxwell's equations, of the wave equation used in the description of pulse propagation. It notes the separation into lamellar and solenoidal (or longitudinal and transverse) and positive and negative frequency parts. It mentions the possibility of separating the polarization field into linear and nonlinear parts, in order to define a susceptibility or index of refraction and, from these, a phase and group velocity. The memo discusses various ways of characterizing the polarization characteristics of plane waves, that is, of parameterizing a transverse unit vector, such as the Jones vector, the Stokes vector, and the Poincare sphere. It discusses the connection between macroscopically defined quantities, such as the intensity or, more generally, the Stokes parameters, and microscopic field amplitudes. The material presented here is a portion of a more extensive treatment of propagation to be presented separately. The equations presented here have been described in various books and articles. They are collected here as a summary and review of theory needed when treating pulse propagation

Traveling waves of the regularized short pulse equation

International Nuclear Information System (INIS)

Shen, Y; Horikis, T P; Kevrekidis, P G; Frantzeskakis, D J

2014-01-01

The properties of the so-called regularized short pulse equation (RSPE) are explored with a particular focus on the traveling wave solutions of this model. We theoretically analyze and numerically evolve two sets of such solutions. First, using a fixed point iteration scheme, we numerically integrate the equation to find solitary waves. It is found that these solutions are well approximated by a finite sum of hyperbolic secants powers. The dependence of the soliton's parameters (height, width, etc) to the parameters of the equation is also investigated. Second, by developing a multiple scale reduction of the RSPE to the nonlinear Schrödinger equation, we are able to construct (both standing and traveling) envelope wave breather type solutions of the former, based on the solitary wave structures of the latter. Both the regular and the breathing traveling wave solutions identified are found to be robust and should thus be amenable to observations in the form of few optical cycle pulses. (paper)

[Experimental study of brain lesions after combined coaxial exposure to high-peaked pulse wave form CO2 and Nd: YAG lasers on the brain].

Science.gov (United States)

Tsuyumu, M; Verasques, G; Yamazaki, S; Kuroiwa, T; Suzuki, R; Takei, H; Suzuki, K; Inaba, Y

1985-04-01

The CO2 laser is useful for cutting and vaporization but not for coagulation and hemostasis. On the contrary, YAG laser is effective for coagulation and hemostasis but not for cutting. The purpose of this study is to examine the effect of the exposure of combined, coaxial CO2 and YAG laser on the animal brain to supplement the advantages and draw-backs of each other. To compare these results, each of non-combined pulse wave form CO2 and YAG lasers was employed separately. The lasers in this study were pulse wave form CO2 and YAG lasers, employed separately or simultaneously using 130 YZ of Nihon Infrared Industries Company. Japanese white rabbits were anesthetized with pentobarbital. Fronto-parietal burr holes were made, the dura was removed and then Evans blue solution was injected intravenously. The lasers were employed to the cerebral cortex without great vessels using a micromanipulator attached to the operative microscope with a distance of 30 cm. The spot size was 700 mu for CO2 laser and 1200 mu for YAG laser. The first experiment was to see the effect of nine combinations of simultaneous coaxial CO2 of 2, 4 and 8 watts and YAG lasers of 10, 20 and 40 watts, 1 sec on the brain. In the second experiment, also combining two lasers, the exposure time of YAG laser was elongated from 1 or 2 seconds into 2 or 4 seconds and the arrangement of powers was the same as that of the first experiment. The lesions were thus made in 18 different conditions.(ABSTRACT TRUNCATED AT 250 WORDS)

Travelling waves in models of neural tissue: from localised structures to periodic waves

NARCIS (Netherlands)

Meijer, Hil Gaétan Ellart; Coombes, Stephen

2014-01-01

We consider travelling waves (fronts, pulses and periodics) in spatially extended one dimensional neural field models. We demonstrate for an excitatory field with linear adaptation that, in addition to an expected stable pulse solution, a stable anti-pulse can exist. Varying the adaptation strength

[De-noising and measurement of pulse wave velocity of the wavelet].

Science.gov (United States)

Liu, Baohua; Zhu, Honglian; Ren, Xiaohua

2011-02-01

Pulse wave velocity (PWV) is a vital index of the cardiovascular pathology, so that the accurate measurement of PWV can be of benefit for prevention and treatment of cardiovascular diseases. The noise in the measure system of pulse wave signal, rounding error and selection of the recording site all cause errors in the measure result. In this paper, with wavelet transformation to eliminate the noise and to raise the precision, and with the choice of the point whose slope was maximum as the recording site of the reconstructing pulse wave, the measuring system accuracy was improved.

Development of integrated photoplethysmographic recording circuit for trans-nail pulse-wave monitoring system

Science.gov (United States)

Qian, Zhengyang; Takezawa, Yoshiki; Shimokawa, Kenji; Kino, Hisashi; Fukushima, Takafumi; Kiyoyama, Koji; Tanaka, Tetsu

2018-04-01

Health monitoring and self-management have become increasingly more important because of health awareness improvement, the aging of population, and other reasons. In general, pulse waves are among the most useful physiological signals that can be used to calculate several parameters such as heart rate and blood pressure for health monitoring and self-management. To realize an automatic and real-time pulse-wave monitoring system that can be used in daily life, we have proposed a trans-nail pulse-wave monitoring system that was placed on the fingernail to detect photoplethysmographic (PPG) signals as pulse waves. In this study, we designed a PPG recording circuit that was composed of a 600 × 600 µm2 photodiode (PD), an LED driver with pulse wave modulation (PWM) and a low-frequency ring oscillator (RING), and a PPG signal readout circuit. The proposed circuit had a very small area of 2.2 × 1.1 mm2 designed with 0.18 µm CMOS technology. The proposed circuit was used to detect pulse waves on the human fingernail in both the reflection and transmission modes. Electrical characteristics of the prototype system were evaluated precisely and PPG waveforms were obtained successfully.

Steering wave packet dynamics and population transfer between electronic states of the Na2 molecule by femtosecond laser pulses

International Nuclear Information System (INIS)

Yuan Kaijun; Sun Zhigang; Cong Shulin; Wang Senming; Yu Jie; Lou Nanquan

2005-01-01

An approach used for steering the wave packet dynamics and the population transfer between electronic states of the Na 2 molecule by a pair of femtosecond laser pulses is demonstrated. Four controlling schemes, i.e., four different combinations of time delays (intuitive and counterintuitive sequences) and frequency detunings (positive and negative detunings), are discussed in detail. The light-induced potentials are used to describe the wave packet dynamics and population transfer. The numerical results show that the wave packet excited by femtosecond laser pulses oscillates drastically on 2 1 Π g state with time. The efficiency of controlling population transfer from the X 1 Σ g + to2 1 Π g states of Na 2 is nearly 100% for the schemes of the counterintuitive sequence pulses with positive and negative detunings

A hybrid pulse combining topology utilizing the combination of modularized avalanche transistor Marx circuits, direct pulse adding, and transmission line transformer.

Science.gov (United States)

Li, Jiangtao; Zhao, Zheng; Sun, Yi; Liu, Yuhao; Ren, Ziyuan; He, Jiaxin; Cao, Hui; Zheng, Minjun

2017-03-01

Numerous applications driven by pulsed voltage require pulses to be with high amplitude, high repetitive frequency, and narrow width, which could be satisfied by utilizing avalanche transistors. The output improvement is severely limited by power capacities of transistors. Pulse combining is an effective approach to increase the output amplitude while still adopting conventional pulse generating modules. However, there are drawbacks in traditional topologies including the saturation tendency of combining efficiency and waveform oscillation. In this paper, a hybrid pulse combining topology was adopted utilizing the combination of modularized avalanche transistor Marx circuits, direct pulse adding, and transmission line transformer. The factors affecting the combining efficiency were determined including the output time synchronization of Marx circuits, and the quantity and position of magnetic cores. The numbers of the parallel modules and the stages were determined by the output characteristics of each combining method. Experimental results illustrated the ability of generating pulses with 2-14 kV amplitude, 7-11 ns width, and a maximum 10 kHz repetitive rate on a matched 50-300 Ω resistive load. The hybrid topology would be a convinced pulse combining method for similar nanosecond pulse generators based on the solid-state switches.

Deep tissue optical imaging of upconverting nanoparticles enabled by exploiting higher intrinsic quantum yield through use of millisecond single pulse excitation with high peak power

DEFF Research Database (Denmark)

Liu, Haichun; Xu, Can T.; Dumlupinar, Gökhan

2013-01-01

We have accomplished deep tissue optical imaging of upconverting nanoparticles at 800 nm, using millisecond single pulse excitation with high peak power. This is achieved by carefully choosing the pulse parameters, derived from time-resolved rate-equation analysis, which result in higher intrinsic...... quantum yield that is utilized by upconverting nanoparticles for generating this near infrared upconversion emission. The pulsed excitation approach thus promises previously unreachable imaging depths and shorter data acquisition times compared with continuous wave excitation, while simultaneously keeping...... therapy and remote activation of biomolecules in deep tissues....

Pulsed lower-hybrid wave penetration in reactor plasmas

International Nuclear Information System (INIS)

Cohen, R.H.; Bonoli, P.T.; Porkolab, M.; Rognlien, T.D.

1989-01-01

Providing lower-hybrid power in short, intense (GW) pulses allows enhanced wave penetration in reactor-grade plasmas. We examine nonlinear absorption, ray propagation, and parametric instability of the intense pulses. We find that simultaneously achieving good penetration while avoiding parametric instabilities is possible, but imposes restrictions on the peak power density, pulse duration, and/or r.f. spot shape. In particular, power launched in narrow strips, elongated along the field direction, is desired

Simulation study on cross polarization scattering of ultrashort-pulse electromagnetic waves

International Nuclear Information System (INIS)

Katsuragawa, Naoki; Hojo, Hitoshi; Mase, Atushi

1996-11-01

Simulation study on cross polarization scattering of ultrashort-pulse electromagnetic waves due to magnetic fluctuations is presented. One-dimensional coupled wave equations for the ordinary and extraordinary modes are solved for incident unipolar sub-cycle pulses in an inhomogeneous magnetized plasma. It is shown that the peak frequencies in the frequency-spectral signals of the mode-converted reflected waves are determined from the Bragg resonance condition in the wave numbers of the ordinary mode, the extraordinary mode and the magnetic fluctuations for relatively short-wavelength localized magnetic fluctuations. (author)

Spectrally modified chirped pulse generation of sustained shock waves

International Nuclear Information System (INIS)

McGrane, S.D.; Moore, D.S.; Funk, D.J.; Rabie, R.L.

2002-01-01

A method is described for generating shock waves with 10-20 ps risetime followed by >200 ps constant pressure, using spectrally modified (clipped) chirped laser pulses. The degree of spectral clipping alters the chirped pulse temporal intensity profile and thereby the time-dependent pressure (tunable via pulse energy) generated in bare and nitrocellulose-coated Al thin films. The method is implementable in common chirped amplified lasers, and allows synchronous probing with a <200 fs pulse

Echocardiographic Assessment of Left Ventricular Function in Healthy Horses and in Horses with Heart Disease Using Pulsed-Wave Tissue Doppler Imaging.

Science.gov (United States)

Koenig, T R; Mitchell, K J; Schwarzwald, C C

2017-03-01

Assessment of left ventricular (LV) function by tissue Doppler imaging (TDI) is not well established in horses with heart disease. To describe the use of pulsed-wave (PW) TDI for the assessment of LV function, establish reference intervals, investigate effects of mitral regurgitation (MR), aortic regurgitation (AR), and primary myocardial disease (MD), and provide proof of concept for the use of PW TDI in Warmblood horses with heart disease. Thirty healthy horses, 38 horses with MR, 25 with AR, 8 with MD. Echocardiograms were retrospectively analyzed. Reference intervals were calculated. PW TDI indices of healthy horses and horses with MR, AR, and MD were compared by one-way ANOVA and Dunnett's test. A complete set of PW TDI variables could be obtained in 94 of 101 horses. Variables corresponding to isovolumic intervals were most difficult to measure. Valvular regurgitation influenced variables describing isovolumic contraction and ejection. Horses with MD had significantly shortened ET m (-118.5 [-154.1 to -82.9] ms; mean difference [95% CI of difference of means]), increased PEP m /ET m (0.11 [0.05 to 0.17]), prolonged IMP m (0.28 [0.18 to 0.37]), increased S 1 (8.9 [5.2 to 12.6] cm/s), and decreased E 1 (-2.6 [-4.7 to -0.5] cm/s), E m (-14.2 [-19.9 to -8.5] cm/s), and E m /A m ratio (-1.6 [-2.6 to -0.6]). Pulsed-wave TDI might be useful for detection of LV dysfunction in horses with primary MD. The clinical value of TDI in horses with MR and AR remains uncertain. Copyright © 2017 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

Spectral coherent combination of ultrashort pulses

International Nuclear Information System (INIS)

Ursescu, D.; Banici, R.; Ionel, L.; Rusen, L.; Sandel, S.; Blanaru, C.

2010-01-01

Complete text of publication follows. The coherent beam combination was chosen in several laser systems, including ELI, as a solution to increase the final attainable intensity. However, the coherent beam combination it is also a difficult technique while it has to combine coherently in space and in time several beams amplified in different laser chains. That means in particular that the beams should be in phase in every point of the amplified beam so the spatial beam profiling techniques have to be mastered with high accuracy for all the combined beams. Here it is proposed an alternative coherent beam combination than the use of identical ultrashort pulses. The idea is to spectrally combine laser pulses with complementary spectra. Collinear and non-collinear approaches have been modelled. Ongoing experimental development, including the demonstration of the rephasing for two spectrally complementary ultrashort pulses will be presented. Acknowledgements. The research leading to these results has received funding from the EC's Seventh Framework Programme (LASERLAB-EUROPE, grant agreement no. 228334).

High-intensity focused ultrasound for ex vivo kidney tissue ablation: influence of generator power and pulse duration.

Science.gov (United States)

Häcker, Axel; Köhrmann, Kai Uwe; Knoll, Thomas; Langbein, Sigrun; Steidler, Annette; Kraut, Oliver; Marlinghaus, Ernst; Alken, Peter; Michel, Maurice Stephan

2004-11-01

The therapeutic application of noninvasive tissue ablation by high-intensity focused ultrasound (HIFU) requires precise physical definition of the focal size and determination of control parameters. The objective of this study was to measure the extent of ex-vivo porcine kidney tissue ablation at variable generator parameters and to identify parameters to control lesion size. The ultrasound waves generated by a cylindrical piezoceramic element (1.04 MHz) were focused at a depth of 100 mm using a parabolic reflector (diameter 100 mm). A needle hydrophone was used to measure the field distribution of the sound pressure. The morphology and extent of tissue necrosis were examined at generator powers of up to 400 W (P(el)) and single pulse durations of as long as 8 seconds. The two-dimensional field distribution resulted in an approximately ellipsoidal focus of 32 x 4 mm (-6 dB). A sharp demarcation between coagulation necrosis and intact tissue was observed. Lesion size was controlled by both the variation of generator power and the pulse duration. At a constant pulse duration of 2 seconds, a generator power of 100 W remained below the threshold doses for inducing a reproducible lesion. An increase in power to as high as 400 W induced lesions with average dimensions of as much as 11.2 x 3 mm. At constant total energy (generator power x pulse duration), lesion size increased at higher generator power. This ultrasound generator can induce defined and reproducible necrosis in ex-vivo kidney tissue. Lesion size can be controlled by adjusting the generator power and pulse duration. Generator power, in particular, turned out to be a suitable control parameter for obtaining a lesion of a defined size.

P-wave pulse analysis to retrieve source and propagation effects in the case of Vrancea earthquakes

International Nuclear Information System (INIS)

Popescu, E.; Popa, M.; Placinta, A.; Grecu, B.; Radulian, M.

2004-01-01

Seismic source parameters and attenuation structure properties are obtained from the first P-wave pulse analysis and empirical Green's function deconvolution. The P pulse characteristics are combined effects of source and path properties. To reproduce the real source and structure parameters it is crucial to apply a method able to distinguish between the different factors affecting the observed seismograms. For example the empirical Green's function deconvolution method (Hartzell, 1978) allows the retrieval of the apparent source time function or source spectrum corrected for path, site and instrumental effects. The apparent source duration is given by the width of the deconvoluted source pulse and is directly related to the source dimension. Once the source time function established, next we can extract the parameters related to path effects. The difference between the pulse recorded at a given station and the source pulse obtained by deconvolution is a measure of the attenuation along the path from focus to the station. On the other hand, the pulse width variations with azimuth depend critically on the fault plane orientation and source directivity. In favourable circumstances (high signal/noise ratio, high resolution and station coverage), the method of analysis proposed in this paper allows the constraint of the rupture plane among the two nodal planes characterizing the fault plane solution, even for small events. P-wave pulse analysis was applied for 25 Vrancea earthquakes recorded between 1999 and 2003 by the Romanian local network to determine source parameters and attenuation properties. Our results outline high-stress drop seismic energy release with relatively simple rupture process for the considered events and strong lateral variation of attenuation of seismic waves across Carpathians Arc. (authors)

Theory of spin and lattice wave dynamics excited by focused laser pulses

Science.gov (United States)

Shen, Ka; Bauer, Gerrit E. W.

2018-06-01

We develop a theory of spin wave dynamics excited by ultrafast focused laser pulses in a magnetic film. We take into account both the volume and surface spin wave modes in the presence of applied, dipolar and magnetic anisotropy fields and include the dependence on laser spot exposure size and magnetic damping. We show that the sound waves generated by local heating by an ultrafast focused laser pulse can excite a wide spectrum of spin waves (on top of a dominant magnon–phonon contribution). Good agreement with recent experiments supports the validity of the model.

Modeling the Pulse Signal by Wave-Shape Function and Analyzing by Synchrosqueezing Transform.

Science.gov (United States)

Wu, Hau-Tieng; Wu, Han-Kuei; Wang, Chun-Li; Yang, Yueh-Lung; Wu, Wen-Hsiang; Tsai, Tung-Hu; Chang, Hen-Hong

2016-01-01

We apply the recently developed adaptive non-harmonic model based on the wave-shape function, as well as the time-frequency analysis tool called synchrosqueezing transform (SST) to model and analyze oscillatory physiological signals. To demonstrate how the model and algorithm work, we apply them to study the pulse wave signal. By extracting features called the spectral pulse signature, and based on functional regression, we characterize the hemodynamics from the radial pulse wave signals recorded by the sphygmomanometer. Analysis results suggest the potential of the proposed signal processing approach to extract health-related hemodynamics features.

Analysis of pulse thermography using similarities between wave and diffusion propagation

Science.gov (United States)

Gershenson, M.

2017-05-01

Pulse thermography or thermal wave imaging are commonly used as nondestructive evaluation (NDE) method. While the technical aspect has evolve with time, theoretical interpretation is lagging. Interpretation is still using curved fitting on a log log scale. A new approach based directly on the governing differential equation is introduced. By using relationships between wave propagation and the diffusive propagation of thermal excitation, it is shown that one can transform from solutions in one type of propagation to the other. The method is based on the similarities between the Laplace transforms of the diffusion equation and the wave equation. For diffusive propagation we have the Laplace variable s to the first power, while for the wave propagation similar equations occur with s2. For discrete time the transformation between the domains is performed by multiplying the temperature data vector by a matrix. The transform is local. The performance of the techniques is tested on synthetic data. The application of common back projection techniques used in the processing of wave data is also demonstrated. The combined use of the transform and back projection makes it possible to improve both depth and lateral resolution of transient thermography.

Elimination of spiral waves and spatiotemporal chaos by the pulse with a specific spatiotemporal configuration

International Nuclear Information System (INIS)

Yuan Guoyong; Yang Shiping; Wang Guangrui; Chen Shigang

2008-01-01

Spiral waves and spatiotemporal chaos are sometimes harmful and should be controlled. In this paper spiral waves and spatiotemporal chaos are successfully eliminated by the pulse with a very specific spatiotemporal configuration. The excited position D of spiral waves or spatiotemporal chaos is first recorded at an arbitrary time (t 0 ). When the system at the domain D enters a recovering state, the external pulse is injected into the domain. If the intensity and the working time of the pulse are appropriate, spiral waves and spatiotemporal chaos can finally be eliminated because counter-directional waves can be generated by the pulse. There are two advantages in the method. One is that the tip can be quickly eliminated together with the body of spiral wave, and the other is that the injected pulse may be weak and the duration can be very short so that the original system is nearly not affected, which is important for practical applications

Laser-supported detonation waves and pulsed laser propulsion

International Nuclear Information System (INIS)

Kare, J.

1990-01-01

A laser thermal rocket uses the energy of a large remote laser, possibly ground-based, to heat an inert propellant and generate thrust. Use of a pulsed laser allows the design of extremely simple thrusters with very high performance compared to chemical rockets. The temperatures, pressures, and fluxes involved in such thrusters (10 4 K, 10 2 atmospheres, 10 7 w/cm 2 ) typically result in the creation of laser-supported detonation (LSD) waves. The thrust cycle thus involves a complex set of transient shock phenomena, including laser-surface interactions in the ignition of the LSD wave, laser-plasma interactions in the LSD wave itself, and high-temperature nonequilibrium chemistry behind the LSD wave. The SDIO Laser Propulsion Program is investigating these phenomena as part of an overall effort to develop the technology for a low-cost Earth-to-orbit laser launch system. We will summarize the Program's approach to developing a high performance thruster, the double-pulse planar thruster, and present an overview of some results obtained to date, along with a discussion of the many research question still outstanding in this area

Heat wave propagation in a thin film irradiated by ultra-short laser pulses

International Nuclear Information System (INIS)

Yoo, Jae Gwon; Kim, Cheol Jung; Lim, C. H.

2004-01-01

A thermal wave solution of a hyperbolic heat conduction equation in a thin film is developed on the basis of the Green's function formalism. Numerical computations are carried out to investigate the temperature response and the propagation of the thermal wave inside a thin film due to a heat pulse generated by ultra-short laser pulses with various laser pulse durations and thickness of the film

Wake-Field Wave Resonant Excitation in Magnetized Plasmas by Electromagnetic Pulse

International Nuclear Information System (INIS)

Milant'ev, V.P.; Turikov, V.A.

2006-01-01

In this paper the space charge wave excitation process at electromagnetic pulse propagation along external magnetic field in vicinity of electron cyclotron resonance. In hydrodynamic approach it is obtained an equation for plasma density under ponderomotive force action. With help of this equation we investigated a wake-field wave amplitude dependence from resonance detuning. The numerical simulation using a PIC method electromagnetic pulse propagation process in the resonant conditions was done

A Skin-attachable Flexible Piezoelectric Pulse Wave Energy Harvester

International Nuclear Information System (INIS)

Yoon, Sunghyun; Cho, Young-Ho

2014-01-01

We present a flexible piezoelectric generator, capable to harvest energy from human arterial pulse wave on the human wrist. Special features and advantages of the flexible piezoelectric generator include the multi-layer device design with contact windows and the simple fabrication process for the higher flexibility with the better energy harvesting efficiency. We have demonstrated the design effectiveness and the process simplicity of our skin- attachable flexible piezoelectric pulse wave energy harvester, composed of the sensitive P(VDF-TrFE) piezoelectric layer on the flexible polyimide support layer with windows. We experimentally characterize and demonstrate the energy harvesting capability of 0.2∼1.0μW in the Human heart rate range on the skin contact area of 3.71cm 2 . Additional physiological and/or vital signal monitoring devices can be fabricated and integrated on the skin attachable flexible generator, covered by an insulation layer; thus demonstrating the potentials and advantages of the present device for such applications to the flexible multi-functional selfpowered artificial skins, capable to detect physiological and/or vital signals on Human skin using the energy harvested from arterial pulse waves

Oscillatory pulses and wave trains in a bistable reaction-diffusion system with cross diffusion.

Science.gov (United States)

Zemskov, Evgeny P; Tsyganov, Mikhail A; Horsthemke, Werner

2017-01-01

We study waves with exponentially decaying oscillatory tails in a reaction-diffusion system with linear cross diffusion. To be specific, we consider a piecewise linear approximation of the FitzHugh-Nagumo model, also known as the Bonhoeffer-van der Pol model. We focus on two types of traveling waves, namely solitary pulses that correspond to a homoclinic solution, and sequences of pulses or wave trains, i.e., a periodic solution. The effect of cross diffusion on wave profiles and speed of propagation is analyzed. We find the intriguing result that both pulses and wave trains occur in the bistable cross-diffusive FitzHugh-Nagumo system, whereas only fronts exist in the standard bistable system without cross diffusion.

Shock wave generation in laser ablation studied using pulsed digital holographic interferometry

Energy Technology Data Exchange (ETDEWEB)

Amer, Eynas; Gren, Per; Sjoedahl, Mikael [Division of Experimental Mechanics, Luleaa University of Technology, SE-971 87 Luleaa (Sweden)], E-mail: eynas.amer@ltu.se, E-mail: per.gren@ltu.se, E-mail: mikael.sjodahl@ltu.se

2008-11-07

Pulsed digital holographic interferometry has been used to study the shock wave induced by a Q-switched Nd-YAG laser ({lambda} = 1064 nm and pulse duration 12 ns) on a polycrystalline boron nitride (PCBN) ceramic target under atmospheric air pressure. A special setup based on using two synchronized wavelengths from the same laser for processing and measurement simultaneously has been introduced. Collimated laser light ({lambda} = 532 nm) passed through the volume along the target and digital holograms were recorded for different time delays after processing starts. Numerical data of the integrated refractive index field were calculated and presented as phase maps showing the propagation of the shock wave generated by the process. The location of the induced shock wave front was observed for different focusing and time delays. The amount of released energy, i.e. the part of the incident energy of the laser pulse that is eventually converted to a shock wave has been estimated using the point explosion model. The released energy is normalized by the incident laser pulse energy and the energy conversion efficiency between the laser pulse and PCBN target has been calculated at different power densities. The results show that the energy conversion efficiency seems to be constant around 80% at high power densities.

Studies of nanosecond pulse surface ionization wave discharges over solid and liquid dielectric surfaces

International Nuclear Information System (INIS)

Petrishchev, Vitaly; Leonov, Sergey; Adamovich, Igor V

2014-01-01

Surface ionization wave discharges generated by high-voltage nanosecond pulses, propagating over a planar quartz surface and over liquid surfaces (distilled water and 1-butanol) have been studied in a rectangular cross section test cell. The discharge was initiated using a custom-made, alternating polarity, high-voltage nanosecond pulse plasma generator, operated at a pulse repetition rate of 100–500 Hz, with a pulse peak voltage and current of 10–15 kV and 7–20 A, respectively, a pulse FWHM of ∼100 ns, and a coupled pulse energy of 2–9 mJ/pulse. Wave speed was measured using a capacitive probe. ICCD camera images demonstrated that the ionization wave propagated predominantly over the quartz wall or over the liquid surface adjacent to the grounded waveguide placed along the bottom wall of the test cell. Under all experimental conditions tested, the surface plasma ‘sheet’ was diffuse and fairly uniform, both for positive and negative polarities. The parameters of ionization wave discharge propagating over distilled water and 1-butanol surfaces were close to those of the discharge over a quartz wall. No perturbation of the liquid surface by the discharge was detected. In most cases, the positive polarity surface ionization wave propagated at a higher speed and over a longer distance compared to the negative polarity wave. For all three sets of experiments (surface ionization wave discharge over quartz, water and 1-butanol), wave speed and travel distance decreased with pressure. Diffuse, highly reproducible surface ionization wave discharge was also observed over the liquid butanol–saturated butanol vapor interface, as well as over the distilled water–saturated water vapor interface, without buffer gas flow. No significant difference was detected between surface ionization discharges sustained using single-polarity (positive or negative), or alternating polarity high-voltage pulses. Plasma emission images yielded preliminary evidence of charge

Modeling the Pulse Signal by Wave-Shape Function and Analyzing by Synchrosqueezing Transform.

Directory of Open Access Journals (Sweden)

Hau-Tieng Wu

Full Text Available We apply the recently developed adaptive non-harmonic model based on the wave-shape function, as well as the time-frequency analysis tool called synchrosqueezing transform (SST to model and analyze oscillatory physiological signals. To demonstrate how the model and algorithm work, we apply them to study the pulse wave signal. By extracting features called the spectral pulse signature, and based on functional regression, we characterize the hemodynamics from the radial pulse wave signals recorded by the sphygmomanometer. Analysis results suggest the potential of the proposed signal processing approach to extract health-related hemodynamics features.

MOSFET-based high voltage double square-wave pulse generator with an inductive adder configuration

Energy Technology Data Exchange (ETDEWEB)

Zhao, Xin [State Key Laboratory of Electrical Insulation and Power Equipment, Xi' an Jiaotong University, Xi' an 710049 (China); Zhang, Qiaogen, E-mail: hvzhang@mail.xjtu.edu.cn [State Key Laboratory of Electrical Insulation and Power Equipment, Xi' an Jiaotong University, Xi' an 710049 (China); Long, Jinghua [College of Physics, Shenzhen University, Shenzhen 518060 (China); Lei, Yunfei; Liu, Jinyuan [Institute of Optoelectronics, Shenzhen University, Shenzhen 518060 (China)

2015-09-01

This paper presents a fast MOSFET-based solid-state pulse generator for high voltage double square-wave pulses. The generator consists mainly of an inductive adder system stacked of 20 solid-state modules. Each of the modules has 18 power MOSFETs in parallel, which are triggered by individual drive circuits; these drive circuits themselves are synchronously triggered by a signal from avalanche transistors. Our experiments demonstrate that the output pulses with amplitude of 8.1 kV and peak current of about 405 A are available at a load impedance of 20 Ω. The pulse has a double square-wave form with a rise and fall time of 40 ns and 26 ns, respectively and bottom flatness better than 12%. The interval time of the double square-wave pulses can be adjustable by varying the interval time of the trigger pulses.

Imaging monitored loosening of dense fibrous tissues using high-intensity pulsed ultrasound

International Nuclear Information System (INIS)

Yeh, Chia-Lun; Li, Pai-Chi; Kuo, Po-Ling; Shih, Wen-Pin; Huang, Pei-Shin

2013-01-01

Pulsed high-intensity focused ultrasound (HIFU) is proposed as a new alternative treatment for contracture of dense fibrous tissue. It is hypothesized that the pulsed-HIFU can release the contracted tissues by attenuating tensile stiffness along the fiber axis, and that the stiffness reduction can be quantitatively monitored by change of B-mode images. Fresh porcine tendons and ligaments were adapted to an ex vivo model and insonated with pulsed-HIFU for durations ranging from 5 to 30 min. The pulse length was 91 µs with a repetition frequency of 500 Hz, and the peak rarefactional pressure was 6.36 MPa. The corresponding average intensities were kept around 1606 W cm −2 for I SPPA and 72.3 W cm −2 for I SPTA . B-mode images of the tissues were acquired before and after pulsed-HIFU exposure, and the changes in speckle intensity and organization were analyzed. The tensile stiffness of the HIFU-exposed tissues along the longitudinal axis was examined using a stretching machine. Histology examinations were performed by optical and transmission electron microscopy. Pulsed-HIFU exposure significantly decreased the tensile stiffness of the ligaments and tendons. The intensity and organization of tissue speckles in the exposed region were also decreased. The speckle changes correlated well with the degree of stiffness alteration. Histology examinations revealed that pulsed-HIFU exposure probably damages tissues via a cavitation-mediated mechanism. Our results suggest that pulsed-HIFU with a low duty factor is a promising tool for developing new treatment strategies for orthopedic disorders. (paper)

Histologic evaluation of laser lipolysis comparing continuous wave vs pulsed lasers in an in vivo pig model.

Science.gov (United States)

Levi, Jessica R; Veerappan, Anna; Chen, Bo; Mirkov, Mirko; Sierra, Ray; Spiegel, Jeffrey H

2011-01-01

To evaluate acute and delayed laser effects of subdermal lipolysis and collagen deposition using an in vivo pig model and to compare histologic findings in fatty tissue after continuous wave diode (CW) vs pulsed laser treatment. Three CW lasers (980, 1370, and 1470 nm) and 3 pulsed lasers (1064, 1320, and 1440 nm) were used to treat 4 Göttingen minipigs. Following administration of Klein tumescent solution, a laser cannula was inserted at the top of a 10 × 2.5-cm rectangle and was passed subdermally to create separate laser "tunnels." Temperatures at the surface and at intervals of 4-mm to 20-mm depths were recorded immediately after exposure and were correlated with skin injury. Full-thickness cutaneous biopsy specimens were obtained at 1 day, 1 week, and 1 month after exposure and were stained with hematoxylin-eosin and trichrome stain. Qualitative and semiquantitative histopathologic evaluations were performed with attention to vascular damage, lipolysis, and collagen deposition. Skin surface damage occurred at temperatures exceeding 46°C. Histologic examination at 1 day after exposure showed hemorrhage, fibrous collagen fiber coagulation, and adipocyte damage. Adipocytes surrounded by histiocytes, a marker of lipolysis, were present at 1 week and 1 month after exposure. Collagen deposition in subdermal fatty tissue and in reticular dermis of some specimens was noted at 1 week and had increased at 1 month. Tissue treated with CW laser at 1470 nm demonstrated greater hemorrhage and more histiocytes at damage sites than tissue treated with pulsed laser at 1440 nm. There was a trend toward more collagen deposition with pulsed lasers than with CW lasers, but this was not statistically significant. Histopathologic comparison between results of CW laser at 980 nm vs pulsed laser at 1064 nm showed the same trend. Hemorrhage differences may result from pulse duration variations. A theoretical calculation estimating temperature rise in vessels supported this

Visualization of femtosecond laser pulse-induced microincisions inside crystalline lens tissue.

Science.gov (United States)

Stachs, Oliver; Schumacher, Silvia; Hovakimyan, Marine; Fromm, Michael; Heisterkamp, Alexander; Lubatschowski, Holger; Guthoff, Rudolf

2009-11-01

To evaluate a new method for visualizing femtosecond laser pulse-induced microincisions inside crystalline lens tissue. Laser Zentrum Hannover e.V., Hannover, Germany. Lenses removed from porcine eyes were modified ex vivo by femtosecond laser pulses (wavelength 1040 nm, pulse duration 306 femtoseconds, pulse energy 1.0 to 2.5 microJ, repetition rate 100 kHz) to create defined planes at which lens fibers separate. The femtosecond laser pulses were delivered by a 3-dimension (3-D) scanning unit and transmitted by focusing optics (numerical aperture 0.18) into the lens tissue. Lens fiber orientation and femtosecond laser-induced microincisions were examined using a confocal laser scanning microscope (CLSM) based on a Rostock Cornea Module attached to a Heidelberg Retina Tomograph II. Optical sections were analyzed in 3-D using Amira software (version 4.1.1). Normal lens fibers showed a parallel pattern with diameters between 3 microm and 9 microm, depending on scanning location. Microincision visualization showed different cutting effects depending on pulse energy of the femtosecond laser. The effects ranged from altered tissue-scattering properties with all fibers intact to definite fiber separation by a wide gap. Pulse energies that were too high or overlapped too tightly produced an incomplete cutting plane due to extensive microbubble generation. The 3-D CLSM method permitted visualization and analysis of femtosecond laser pulse-induced microincisions inside crystalline lens tissue. Thus, 3-D CLSM may help optimize femtosecond laser-based procedures in the treatment of presbyopia.

Pulsed and Tissue Doppler Echocardiographic Changes in Patients with Thalassemia Major

Directory of Open Access Journals (Sweden)

Taysir S. Garadah

2010-01-01

Full Text Available Background Doppler echocardiographic studies of left ventricle (LV systolic and diastolic function in patients with β-Thalassemia Major (β-TM had shown different patterns of systolic and diastolic dysfunction. Aim This cross-sectional study was designed to study the LV systolic and diastolic function in patients with β-TM using Pulsed Doppler (PD and Tissue Doppler (TD echocardiography. Methods All patients were evaluated clinically and by echocardiography, The study included patients with β-TM (n = 38, age 15.7 ± 8.9 years compared with an age-matched control group (n = 38, age 15.9 ± 8.9 years. The pulse Doppler indices were normalized for age and heart rate. Results Compared with control patients, M-Mode showed that patients with β-TM have thicker LV septal wall index (0.659 ± 0.23 vs. 0.446 ± 0.219 cm, P ≤ 0.001, posterior wall index (0.659 ± 0.235 vs. 0.437 ± 0.214 cm, P ≤ 0.01, and larger LVEDD index is (3.99 ± 0.48 vs. 2.170 ± 0.57 mm. P = 0.035. Pulsed Doppler showed high LV trans-mitral E wave velocity (70.818 ± 10.139 vs. 57.532 ± 10.139, p = 0.027 and E/A ratio (1.54 vs. 1.23, P ≤ 0.01. The duration of Deceleration time (DT and isovolumic relaxation time (IVRT were significantly shorter in patients with β-TM (150.234 ± 20.0.23 vs. 167.123 ± 19.143 msec, P ≤ 0.01 and (60.647 ± 6.77 vs. 75.474 ± 5.83 msec, P ≤ 0.001, respectively. The ratio of transmitral E wave velocity to the tissue Doppler E wave at the basal septal mitral annulus E/Em – was significantly higher in β-TM group (14.024 ± 2.29 vs. 12.132 ± 1.82, P ≤ 0.01. The Tissue Doppler systolic velocity (Sm and the early diastolic velocity (Em were significantly lower in β-TM group compared to control (4.31 ± 1.2 cm/s vs. 6.95 ± 2.1, P ≤ 0.01 and 4.31 ± 2.7 cm/s vs. 5.82 ± 2.5, P ≤ 0.01 respectively. The tricuspid valve velocity was significantly higher than controls (2.993 ± 0.569 vs. 1.93 ± 0.471 m/sec, respectively, P ≤ 0

[Research on vigilance detection based on pulse wave].

Science.gov (United States)

Cao, Yong; Jiao, Xuejun; Pan, Jinjin; Jiang, Jin; Fu, Jiahao; Xu, Fenggang; Yang, Hanjun

2017-12-01

This paper studied the rule for the change of vigilance based on pulse wave. 10 participants were recruited in a 95-minute Mackworth clock test (MCT) experiment. During the experiment, the vigilance of all participants were evaluated by Karolinska sleepiness scale (KSS) and Stanford sleepiness scale (SSS), and behavior data (the reaction time and the accuracy of target) and pulse wave signal of the participants were recorded simultaneously. The result indicated that vigilance of the participants can be divided into 3 classes: the first 30 minutes for high vigilance level, the middle 30 minutes for general vigilance level, and the last 30 minutes for low vigilance level. Besides, time domain features such as amplitude of secondary peak, amplitude of peak and the latency of secondary peak decreased with the decrease of vigilance, while the amplitude of troughs increased. In terms of frequency domain features, the energy of 4 frequency band including 8.600 ~ 9.375 Hz, 11.720 ~ 12.500 Hz, 38.280 ~ 39.060 Hz and 39.060 ~ 39.840 Hz decreased with the decrease of vigilance. Finally, under the recognition model established by the 8 characteristics mentioned above, the average accuracy of three-classification results over the 10 participants was as high as 88.7%. The results of this study confirmed the feasibility of pulse wave in the evaluation of vigilance, and provided a new way for the real-time monitoring of vigilance.

The velocity of the arterial pulse wave: a viscous-fluid shock wave in an elastic tube.

Science.gov (United States)

Painter, Page R

2008-07-29

The arterial pulse is a viscous-fluid shock wave that is initiated by blood ejected from the heart. This wave travels away from the heart at a speed termed the pulse wave velocity (PWV). The PWV increases during the course of a number of diseases, and this increase is often attributed to arterial stiffness. As the pulse wave approaches a point in an artery, the pressure rises as does the pressure gradient. This pressure gradient increases the rate of blood flow ahead of the wave. The rate of blood flow ahead of the wave decreases with distance because the pressure gradient also decreases with distance ahead of the wave. Consequently, the amount of blood per unit length in a segment of an artery increases ahead of the wave, and this increase stretches the wall of the artery. As a result, the tension in the wall increases, and this results in an increase in the pressure of blood in the artery. An expression for the PWV is derived from an equation describing the flow-pressure coupling (FPC) for a pulse wave in an incompressible, viscous fluid in an elastic tube. The initial increase in force of the fluid in the tube is described by an increasing exponential function of time. The relationship between force gradient and fluid flow is approximated by an expression known to hold for a rigid tube. For large arteries, the PWV derived by this method agrees with the Korteweg-Moens equation for the PWV in a non-viscous fluid. For small arteries, the PWV is approximately proportional to the Korteweg-Moens velocity divided by the radius of the artery. The PWV in small arteries is also predicted to increase when the specific rate of increase in pressure as a function of time decreases. This rate decreases with increasing myocardial ischemia, suggesting an explanation for the observation that an increase in the PWV is a predictor of future myocardial infarction. The derivation of the equation for the PWV that has been used for more than fifty years is analyzed and shown to yield

Enhanced shock wave generation via pre-breakdown acceleration using water electrolysis in negative streamer pulsed spark discharges

Science.gov (United States)

Lee, Kern; Chung, Kyoung-Jae; Hwang, Y. S.

2018-03-01

This paper presents a method for enhancement of shock waves generated from underwater pulsed spark discharges with negative (anode-directed) subsonic streamers, for which the pre-breakdown process is accelerated by preconditioning a gap with water electrolysis. Hydrogen microbubbles are produced at the cathode by the electrolysis and move towards the anode during the preconditioning phase. The numbers and spatial distributions of the microbubbles vary with the amplitude and duration of each preconditioning pulse. Under our experimental conditions, the optimum pulse duration is determined to be ˜250 ms at a pulse voltage of 400 V, where the buoyancy force overwhelms the electric force and causes the microbubbles to be swept out from the water gap. When a high-voltage pulse is applied to the gap just after the preconditioning pulse, the pre-breakdown process is significantly accelerated in the presence of the microbubbles. At the optimum preconditioning pulse duration, the average breakdown delay is reduced by 87% and, more importantly, the energy consumed during the pre-breakdown period decreases by 83%. This reduced energy consumption during the pre-breakdown period, when combined with the morphological advantages of negative streamers, such as thicker and longer stalks, leads to a significant improvement in the measured peak pressure (˜40%) generated by the underwater pulsed spark discharge. This acceleration of pre-breakdown using electrolysis overcomes the biggest drawback of negative subsonic discharges, which is slow vapor bubble formation due to screening effects, and thus enhances the efficiency of the shock wave generation process using pulsed spark discharges in water.

Detailed characterization of CW- and pulsed-pump four-wave mixing in highly nonlinear fibers

DEFF Research Database (Denmark)

Lillieholm, Mads; Galili, Michael; Grüner-Nielsen, L.

2016-01-01

We present a quantitative comparison of continuouswave- (CW) and pulsed-pump four-wave mixing (FWM) in commercially available highly nonlinear fibers (HNLFs), and suggest properties for which the CW and pulsed FWM bandwidths are limited in practice. The CWand pulsed-pump parametric gain is charac......We present a quantitative comparison of continuouswave- (CW) and pulsed-pump four-wave mixing (FWM) in commercially available highly nonlinear fibers (HNLFs), and suggest properties for which the CW and pulsed FWM bandwidths are limited in practice. The CWand pulsed-pump parametric gain...... bandwidth. However, an inverse scaling of the TOD with the dispersion fluctuations, leads to different CW-optimized fibers, which depend only on the even dispersion-orders....

High-frequency dual mode pulsed wave Doppler imaging for monitoring the functional regeneration of adult zebrafish hearts

OpenAIRE

Kang, Bong Jin; Park, Jinhyoung; Kim, Jieun; Kim, Hyung Ham; Lee, Changyang; Hwang, Jae Youn; Lien, Ching-Ling; Shung, K. Kirk

2015-01-01

Adult zebrafish is a well-known small animal model for studying heart regeneration. Although the regeneration of scars made by resecting the ventricular apex has been visualized with histological methods, there is no adequate imaging tool for tracking the functional recovery of the damaged heart. For this reason, high-frequency Doppler echocardiography using dual mode pulsed wave Doppler, which provides both tissue Doppler (TD) and Doppler flow in a same cardiac cycle, is developed with a 30 ...

Enhancement of Lamb Wave Imaging Resolution by Step Pulse Excitation and Prewarping

Directory of Open Access Journals (Sweden)

Shangchen Fu

2015-01-01

Full Text Available For the purpose of improving the damage localization accuracy, a prewarping technology is combined with step pulse excitation and this method is used in Lamb wave imaging of plate structures with adjacent damages. Based on the step pulse excitation, various narrowband or burst response can be derived by signal processing technology and this method provides flexibility for further prewarping approach. A narrowband signal warped with a preselected distance is then designed, and the dispersion in the response of this prewarping signal will be greatly reduced. However, in order to calculate the distance for prewarping, the first arrival needs to be estimated from the burst response. From the step-pulse response, narrowband responses at different central frequencies can be obtained, and by averaging peak-value time of their first arrivals, a more accurate estimation can be calculated. By using the prewarping method to the damage scattering signals before imaging, the imaging resolution of the delay-and-sum method can be highly enhanced. The experiment carried out in an aluminum plate with adjacent damages proves the efficiency of this method.

Pulse wave imaging in normal, hypertensive and aneurysmal human aortas in vivo: a feasibility study

International Nuclear Information System (INIS)

Li, Ronny X; Luo, Jianwen; Shahmirzadi, Danial; Konofagou, Elisa E; Balaram, Sandhya K; Chaudhry, Farooq A

2013-01-01

Arterial stiffness is a well-established biomarker for cardiovascular risk, especially in the case of hypertension. The progressive stages of an abdominal aortic aneurysm (AAA) have also been associated with varying arterial stiffness. Pulse wave imaging (PWI) is a noninvasive, ultrasound imaging-based technique that uses the pulse wave-induced arterial wall motion to map the propagation of the pulse wave and measure the regional pulse wave velocity (PWV) as an index of arterial stiffness. In this study, the clinical feasibility of PWI was evaluated in normal, hypertensive, and aneurysmal human aortas. Radiofrequency-based speckle tracking was used to estimate the pulse wave-induced displacements in the abdominal aortic walls of normal (N = 15, mean age 32.5 ± 10.2 years), hypertensive (N = 13, mean age 60.8 ± 15.8 years), and aneurysmal (N = 5, mean age 71.6 ± 11.8 years) human subjects. Linear regression of the spatio-temporal variation of the displacement waveform in the anterior aortic wall over a single cardiac cycle yielded the slope as the PWV and the coefficient of determination r 2 as an approximate measure of the pulse wave propagation uniformity. The aortic PWV measurements in all normal, hypertensive, and AAA subjects were 6.03 ± 1.68, 6.69 ± 2.80, and 10.54 ± 6.52 m s −1 , respectively. There was no significant difference (p = 0.15) between the PWVs of the normal and hypertensive subjects while the PWVs of the AAA subjects were significantly higher (p 2 in the AAA subjects was significantly lower (p 2 ) obtained using PWI, in addition to the PWI images and spatio-temporal maps that provide qualitative visualization of the pulse wave, may potentially provide valuable information for the clinical characterization of aneurysms and other vascular pathologies that regionally alter the arterial wall mechanics. (paper)

Limited Diffraction Maps for Pulsed Wave Annular Arrays

DEFF Research Database (Denmark)

Fox, Paul D.

2002-01-01

A procedure is provided for decomposing the linear field of flat pulsed wave annular arrays into an equivalent set of known limited diffraction Bessel beams. Each Bessel beam propagates with known characteristics, enabling good insight into the propagation of annular fields to be obtained...

Stress wave focusing transducers

Energy Technology Data Exchange (ETDEWEB)

Visuri, S.R., LLNL

1998-05-15

Conversion of laser radiation to mechanical energy is the fundamental process behind many medical laser procedures, particularly those involving tissue destruction and removal. Stress waves can be generated with laser radiation in several ways: creation of a plasma and subsequent launch of a shock wave, thermoelastic expansion of the target tissue, vapor bubble collapse, and ablation recoil. Thermoelastic generation of stress waves generally requires short laser pulse durations and high energy density. Thermoelastic stress waves can be formed when the laser pulse duration is shorter than the acoustic transit time of the material: {tau}{sub c} = d/c{sub s} where d = absorption depth or spot diameter, whichever is smaller, and c{sub s} = sound speed in the material. The stress wave due to thermoelastic expansion travels at the sound speed (approximately 1500 m/s in tissue) and leaves the site of irradiation well before subsequent thermal events can be initiated. These stress waves, often evolving into shock waves, can be used to disrupt tissue. Shock waves are used in ophthalmology to perform intraocular microsurgery and photodisruptive procedures as well as in lithotripsy to fragment stones. We have explored a variety of transducers that can efficiently convert optical to mechanical energy. One such class of transducers allows a shock wave to be focused within a material such that the stress magnitude can be greatly increased compared to conventional geometries. Some transducer tips could be made to operate regardless of the absorption properties of the ambient media. The size and nature of the devices enable easy delivery, potentially minimally-invasive procedures, and precise tissue- targeting while limiting thermal loading. The transducer tips may have applications in lithotripsy, ophthalmology, drug delivery, and cardiology.

Excitation of plasma waves by nonlinear currents induced by a high-frequency electromagnetic pulse

Energy Technology Data Exchange (ETDEWEB)

Grishkov, V. E.; Uryupin, S. A., E-mail: uryupin@sci.lebedev.ru [Russian Academy of Sciences, Lebedev Physical Institute (Russian Federation)

2017-03-15

Excitation of plasma waves by nonlinear currents induced by a high-frequency electromagnetic pulse is analyzed within the kinetic approach. It is shown that the most efficient source of plasma waves is the nonlinear current arising due to the gradient of the energy density of the high-frequency field. Generation of plasma waves by the drag current is usually less efficient but not negligibly small at relatively high frequencies of electron–ion collisions. The influence of electron collisions on the excitation of plasma waves by pulses of different duration is described quantitatively.

A differential optical interferometer for measuring short pulses of surface acoustic waves.

Science.gov (United States)

Shaw, Anurupa; Teyssieux, Damien; Laude, Vincent

2017-09-01

The measurement of the displacements caused by the propagation of a short pulse of surface acoustic waves on a solid substrate is investigated. A stabilized time-domain differential interferometer is proposed, with the surface acoustic wave (SAW) sample placed outside the interferometer. Experiments are conducted with surface acoustic waves excited by a chirped interdigital transducer on a piezoelectric lithium niobate substrate having an operational bandwidth covering the 200-400MHz frequency range and producing 10-ns pulses with 36nm maximum out-of-plane displacement. The interferometric response is compared with a direct electrical measurement obtained with a receiving wide bandwidth interdigital transducer and good correspondence is observed. The effects of varying the path difference of the interferometer and the measurement position on the surface are discussed. Pulse compression along the chirped interdigital transducer is observed experimentally. Copyright © 2017 Elsevier B.V. All rights reserved.

Laser Ablation of Biological Tissue Using Pulsed CO2 Laser

International Nuclear Information System (INIS)

Hashishin, Yuichi; Sano, Shu; Nakayama, Takeyoshi

2010-01-01

Laser scalpels are currently used as a form of laser treatment. However, their ablation mechanism has not been clarified because laser excision of biological tissue occurs over a short time scale. Biological tissue ablation generates sound (laser-induced sound). This study seeks to clarify the ablation mechanism. The state of the gelatin ablation was determined using a high-speed video camera and the power reduction of a He-Ne laser beam. The aim of this study was to clarify the laser ablation mechanism by observing laser excision using the high-speed video camera and monitoring the power reduction of the He-Ne laser beam. We simulated laser excision of a biological tissue by irradiating gelatin (10 wt%) with radiation from a pulsed CO 2 laser (wavelength: 10.6 μm; pulse width: 80 ns). In addition, a microphone was used to measure the laser-induced sound. The first pulse caused ablation particles to be emitted in all directions; these particles were subsequently damped so that they formed a mushroom cloud. Furthermore, water was initially evaporated by laser irradiation and then tissue was ejected.

Pulse energy evolution for high-resolution Lamb wave inspection

International Nuclear Information System (INIS)

Hua, Jiadong; Zeng, Liang; Gao, Fei; Lin, Jing

2015-01-01

Generally, tone burst excitation methods are used to reduce the effect of dispersion in Lamb wave inspection. In addition, algorithms for dispersion compensation are required to simplify responses, especially in long-range inspection. However, the resolution is always limited by the time duration of tone burst excitation. A pulse energy evolution method is established to overcome this limitation. In this method, a broadband signal with a long time (e.g. a chirp, white noise signal, or a pseudo-random sequence) is used as excitation to actuate Lamb waves. First of all, pulse compression is employed to estimate system impulse response with a high signal-to-noise ratio. Then, dispersion compensation is applied repeatedly with systemically varied compensation distances, obtaining a series of compensated signals. In these signals, amplitude (or energy) evolution associated with the change of compensation distance is utilized to estimate the actual propagation distance of the interested wave packet. Finally, the defect position is detected by an imaging algorithm. Several experiments are given to validate the proposed method. (paper)

Influence trend of temperature distribution in skin tissue generated by different exposure dose pulse laser

Science.gov (United States)

Shan, Ning; Wang, Zhijing; Liu, Xia

2014-11-01

Laser is widely applied in military and medicine fields because of its excellent capability. In order to effectively defend excess damage by laser, the thermal processing theory of skin tissue generated by laser should be carried out. The heating rate and thermal damage area should be studied. The mathematics model of bio-tissue heat transfer that is irradiated by laser is analyzed. And boundary conditions of bio-tissue are discussed. Three layer FEM grid model of bio-tissue is established. The temperature rising inducing by pulse laser in the tissue is modeled numerically by adopting ANSYS software. The changing trend of temperature in the tissue is imitated and studied under the conditions of different exposure dose pulse laser. The results show that temperature rising in the tissue depends on the parameters of pulse laser largely. In the same conditions, the pulse width of laser is smaller and its instant power is higher. And temperature rising effect in the tissue is very clear. On the contrary, temperature rising effect in the tissue is lower. The cooling time inducing by temperature rising effect in the tissue is longer along with pulse separation of laser is bigger. And the temperature difference is bigger in the pulse period.

Models of brachial to finger pulse wave distortion and pressure decrement.

Science.gov (United States)

Gizdulich, P; Prentza, A; Wesseling, K H

1997-03-01

To model the pulse wave distortion and pressure decrement occurring between brachial and finger arteries. Distortion reversion and decrement correction were also our aims. Brachial artery pressure was recorded intra-arterially and finger pressure was recorded non-invasively by the Finapres technique in 53 adult human subjects. Mean pressure was subtracted from each pressure waveform and Fourier analysis applied to the pulsations. A distortion model was estimated for each subject and averaged over the group. The average inverse model was applied to the full finger pressure waveform. The pressure decrement was modelled by multiple regression on finger systolic and diastolic levels. Waveform distortion could be described by a general, frequency dependent model having a resonance at 7.3 Hz. The general inverse model has an anti-resonance at this frequency. It converts finger to brachial pulsations thereby reducing average waveform distortion from 9.7 (s.d. 3.2) mmHg per sample for the finger pulse to 3.7 (1.7) mmHg for the converted pulse. Systolic and diastolic level differences between finger and brachial arterial pressures changed from -4 (15) and -8 (11) to +8 (14) and +8 (12) mmHg, respectively, after inverse modelling, with pulse pressures correct on average. The pressure decrement model reduced both the mean and the standard deviation of systolic and diastolic level differences to 0 (13) and 0 (8) mmHg. Diastolic differences were thus reduced most. Brachial to finger pulse wave distortion due to wave reflection in arteries is almost identical in all subjects and can be modelled by a single resonance. The pressure decrement due to flow in arteries is greatest for high pulse pressures superimposed on low means.

Two-wave generator of subnanosecond radiation pulses on an yttrium-aluminium garnet

International Nuclear Information System (INIS)

Babikov, Yu.I.; Ir, K.S.; Mironov, V.E.

1988-01-01

Great attention is paid to the electron accelerator based on the mechanism of electron accelerator in the field of plasma wave, excited by laser radiation. The laser system master generator based on serial LTIPC-8 laser is described. The system is intended for investigating the plasma excitation processes initiated by two-frequency laser radiation beats. Pulse duration is ≤1 ns at 3-4 pulse train. Radiation on 1.0615 and 1.0641 μm wave length is generated. 5 refs.; 3 figs

Crystal Growth of High-Quality Protein Crystals under the Presence of an Alternant Electric Field in Pulse-Wave Mode, and a Strong Magnetic Field with Radio Frequency Pulses Characterized by X-ray Diffraction

Directory of Open Access Journals (Sweden)

Adela Rodríguez-Romero

2017-06-01

Full Text Available The first part of this research was devoted to investigating the effect of alternate current (AC using four different types of wave modes (pulse-wave at 2 Hz on the crystal growth of lysozyme in solution. The best results, in terms of size and crystal quality, were obtained when protein crystals were grown under the influence of electric fields in a very specific wave mode (“breathing” wave, giving the highest resolution up to 1.34 Å in X-ray diffraction analysis compared with controls and with those crystals grown in gel. In the second part, we evaluated the effect of a strong magnetic field of 16.5 Tesla combined with radiofrequency pulses of 0.43 μs on the crystal growth in gels of tetragonal hen egg white (HEW lysozyme. The lysozyme crystals grown, both in solution applying breathing-wave and in gel under the influence of this strong magnetic field with pulses of radio frequencies, produced the larger-in-size crystals and the highest resolution structures. Data processing and refinement statistics are very good in terms of the resolution, mosaicity and Wilson B factor obtained for each crystal. Besides, electron density maps show well-defined and distinctly separated atoms at several selected tryptophan residues for the crystal grown using the “breathing wave pulses”.

Noncontact sphygmomanometer based on pulse-wave transit time between the face and hand

Science.gov (United States)

Nakano, Kazuya; Ohnishi, Takashi; Nishidate, Izumi; Haneishi, Hideaki

2018-02-01

Systolic blood pressure (SBP) is highly sensitive to various factors such as psychological stress, and hence its continuous monitoring is essential to evaluate different health conditions. However, conventional sphygmomanometers cannot continuously measure SBP given the time-consuming setup based on a pressure cuff. Moreover, continuous biological signal monitoring is more comfortable when no sensors are attached. A solution for continuous SBP estimation is based on pulse transit time (PTT), which determines the time difference between two pulse waves at different body parts. In previous studies, we successfully measured the PTT using a contactless setup composed by two digital color cameras recording the face and hand of subjects. Then, the acquired images were transformed into blood volume by combining multiple regression analysis and a Monte Carlo method. As a result, the delay among images allowed to determine the PPT from pulse waves. In this study, we simultaneously measured SBP and PTT by using a sphygmomanometer and the two cameras, respectively. We evaluated SBP increases (i.e., stressful situations) and the corresponding PPT by asking participants to either grasp a handgrip or momentarily interrupting breath. We also determined the SBP and PTT without asking for such exercises. Comparison results show that the mean PTT under stress was significantly lower than that without stress, which is consistent with an increased SBP. Finally, we related the SBP and PTT by a nonlinear formula with a coefficient of determination of 0.59, thus confirming the effectiveness of the proposed system.

Comparison of soft and hard tissue ablation with sub-ps and ns pulse lasers

Energy Technology Data Exchange (ETDEWEB)

Da Silva, L.B.; Stuart, B.C.; Celliers, P.M.; Feit, M.D.; Glinsky, M.E.; Heredia, N.J.; Herman, S.; Lane, S.M.; London, R.A.; Matthews, D.L.; Perry, M.D.; Rubenchik, A.M. [Lawrence Livermore National Lab., CA (United States); Chang, T.D. [Veterans Administration Hospital, Martinez, CA (United States); Neev, J. [Beckman Laser Inst. and Medical Clinic, Irvine, CA (United States)

1996-05-01

Tissue ablation with ultrashort laser pulses offers several unique advantages. The nonlinear energy deposition is insensitive to tissue type, allowing this tool to be used for soft and hard tissue ablation. The localized energy deposition lead to precise ablation depth and minimal collateral damage. This paper reports on efforts to study and demonstrate tissue ablation using an ultrashort pulse laser. Ablation efficiency and extent of collateral damage for 0.3 ps and 1000 ps duration laser pulses are compared. Temperature measurements of the rear surface of a tooth section is also presented.

Bragg grating rogue wave

Energy Technology Data Exchange (ETDEWEB)

Degasperis, Antonio [Dipartimento di Fisica, “Sapienza” Università di Roma, P.le A. Moro 2, 00185 Roma (Italy); Wabnitz, Stefan, E-mail: stefan.wabnitz@unibs.it [Dipartimento di Ingegneria dell' Informazione, Università degli Studi di Brescia and INO-CNR, via Branze 38, 25123 Brescia (Italy); Aceves, Alejandro B. [Southern Methodist University, Dallas (United States)

2015-06-12

We derive the rogue wave solution of the classical massive Thirring model, that describes nonlinear optical pulse propagation in Bragg gratings. Combining electromagnetically induced transparency with Bragg scattering four-wave mixing may lead to extreme waves at extremely low powers.

Design of a Continuous Blood Pressure Measurement System Based on Pulse Wave and ECG Signals.

Science.gov (United States)

Li, Jian-Qiang; Li, Rui; Chen, Zhuang-Zhuang; Deng, Gen-Qiang; Wang, Huihui; Mavromoustakis, Constandinos X; Song, Houbing; Ming, Zhong

2018-01-01

With increasingly fierce competition for jobs, the pressures on people have risen in recent years, leading to lifestyle and diet disorders that result in significantly higher risks of cardiovascular disease. Hypertension is one of the common chronic cardiovascular diseases; however, mainstream blood pressure measurement devices are relatively heavy. When multiple measurements are required, the user experience and the measurement results may be unsatisfactory. In this paper, we describe the design of a signal collection module that collects pulse waves and electrocardiograph (ECG) signals. The collected signals are input into a signal processing module to filter the noise and amplify the useful physiological signals. Then, we use a wavelet transform to eliminate baseline drift noise and detect the feature points of the pulse waves and ECG signals. We propose the concept of detecting the wave shape associated with an instance, an approach that minimizes the impact of atypical pulse waves on blood pressure measurements. Finally, we propose an improved method for measuring blood pressure based on pulse wave velocity that improves the accuracy of blood pressure measurements by 58%. Moreover, the results meet the american medical instrument promotion association standards, which demonstrate the feasibility of our measurement system.

Amplification of pressure waves in laser-assisted endodontics with synchronized delivery of Er:YAG laser pulses.

Science.gov (United States)

Lukač, Nejc; Jezeršek, Matija

2018-05-01

When attempting to clean surfaces of dental root canals with laser-induced cavitation bubbles, the resulting cavitation oscillations are significantly prolonged due to friction on the cavity walls and other factors. Consequently, the collapses are less intense and the shock waves that are usually emitted following a bubble's collapse are diminished or not present at all. A new technique of synchronized laser-pulse delivery intended to enhance the emission of shock waves from collapsed bubbles in fluid-filled endodontic canals is reported. A laser beam deflection probe, a high-speed camera, and shadow photography were used to characterize the induced photoacoustic phenomena during synchronized delivery of Er:YAG laser pulses in a confined volume of water. A shock wave enhancing technique was employed which consists of delivering a second laser pulse at a delay with regard to the first cavitation bubble-forming laser pulse. Influence of the delay between the first and second laser pulses on the generation of pressure and shock waves during the first bubble's collapse was measured for different laser pulse energies and cavity volumes. Results show that the optimal delay between the two laser pulses is strongly correlated with the cavitation bubble's oscillation period. Under optimal synchronization conditions, the growth of the second cavitation bubble was observed to accelerate the collapse of the first cavitation bubble, leading to a violent collapse, during which shock waves are emitted. Additionally, shock waves created by the accelerated collapse of the primary cavitation bubble and as well of the accompanying smaller secondary bubbles near the cavity walls were observed. The reported phenomena may have applications in improved laser cleaning of surfaces during laser-assisted dental root canal treatments.

Brachial-ankle pulse wave velocity and symptomatic cerebral infarction in patients with type 2 diabetes: a cross-sectional study

Directory of Open Access Journals (Sweden)

Muramatsu Chie

2003-08-01

Full Text Available Abstract Background Recently a new automatic device that measures brachial-ankle pulse wave velocity using an oscillometric method has been developed. However, the practical significance of brachial-ankle pulse wave velocity measurement remains uncertain. The purpose of this study was to examine the association between brachial-ankle pulse wave velocity and symptomatic cerebral infarction in patients with type 2 diabetes. Methods One thousand sixty six patients with type 2 diabetes were studied cross-sectionally. Measurements of brachial-ankle pulse wave velocity were made using the automatic device. Logistic regression analysis was used to calculate the odds ratio for cerebral infarction. Results The presence of symptomatic cerebral infarction was confirmed in 86 patients. In these patients brachial-ankle pulse wave velocity was found to be significantly higher than in patients without cerebral infarction (18.94 ± 4.95 versus 16.46 ± 3.62 m/s, p Conclusion Overall, we conclude that an increase in brachial-ankle pulse wave velocity is associated with symptomatic cerebral infarction in patients with type 2 diabetes.

Design of a bounded wave EMP (Electromagnetic Pulse) simulator

Science.gov (United States)

Sevat, P. A. A.

1989-06-01

Electromagnetic Pulse (EMP) simulators are used to simulate the EMP generated by a nuclear weapon and to harden equipment against the effects of EMP. At present, DREO has a 1 m EMP simulator for testing computer terminal size equipment. To develop the R and D capability for testing larger objects, such as a helicopter, a much bigger threat level facility is required. This report concerns the design of a bounded wave EMP simulator suitable for testing large size equipment. Different types of simulators are described and their pros and cons are discussed. A bounded wave parallel plate type simulator is chosen for it's efficiency and the least environmental impact. Detailed designs are given for 6 m and 10 m parallel plate type wire grid simulators. Electromagnetic fields inside and outside the simulators are computed. Preliminary specifications for a pulse generator required for the simulator are also given. Finally, the electromagnetic fields radiated from the simulator are computed and discussed.

Dispersion-Flattened Composite Highly Nonlinear Fibre Optimised for Broadband Pulsed Four-Wave Mixing

DEFF Research Database (Denmark)

Lillieholm, Mads; Galili, Michael; Oxenløwe, Leif Katsuo

2016-01-01

We present a segmented composite HNLF optimised for mitigation of dispersion-fluctuation impairments for broadband pulsed four-wave mixing. The HNLF-segmentation allows for pulsed FWMprocessing of a 13-nm wide input WDM-signal with -4.6-dB conversion efficiency...

Ultrashort pulse laser processing of hard tissue, dental restoration materials, and biocompatibles

Science.gov (United States)

Yousif, A.; Strassl, M.; Beer, F.; Verhagen, L.; Wittschier, M.; Wintner, E.

2007-07-01

During the last few years, ultra-short laser pulses have proven their potential for application in medical tissue treatment in many ways. In hard tissue ablation, their aptitude for material ablation with negligible collateral damage provides many advantages. Especially teeth representing an anatomically and physiologically very special region with less blood circulation and lower healing rates than other tissues require most careful treatment. Hence, overheating of the pulp and induction of microcracks are some of the most problematic issues in dental preparation. Up till now it was shown by many authors that the application of picosecond or femtosecond pulses allows to perform ablation with very low damaging potential also fitting to the physiological requirements indicated. Beside the short interaction time with the irradiated matter, scanning of the ultra-short pulse trains turned out to be crucial for ablating cavities of the required quality. One main reason for this can be seen in the fact that during scanning the time period between two subsequent pulses incident on the same spot is so much extended that no heat accumulation effects occur and each pulse can be treated as a first one with respect to its local impact. Extension of this advantageous technique to biocompatible materials, i.e. in this case dental restoration materials and titanium plasma-sprayed implants, is just a matter of consequence. Recently published results on composites fit well with earlier data on dental hard tissue. In case of plaque which has to be removed from implants, it turns out that removal of at least the calcified version is harder than tissue removal. Therefore, besides ultra-short lasers, also Diode and Neodymium lasers, in cw and pulsed modes, have been studied with respect to plaque removal and sterilization. The temperature increase during laser exposure has been experimentally evaluated in parallel.

Contactless remote induction of shear waves in soft tissues using a transcranial magnetic stimulation device

International Nuclear Information System (INIS)

Grasland-Mongrain, Pol; Miller-Jolicoeur, Erika; Cloutier, Guy; Tang, An; Catheline, Stefan

2016-01-01

This study presents the first observation of shear waves induced remotely within soft tissues. It was performed through the combination of a transcranial magnetic stimulation device and a permanent magnet. A physical model based on Maxwell and Navier equations was developed. Experiments were performed on a cryogel phantom and a chicken breast sample. Using an ultrafast ultrasound scanner, shear waves of respective amplitudes of 5 and 0.5 μm were observed. Experimental and numerical results were in good agreement. This study constitutes the framework of an alternative shear wave elastography method. (paper)

Contactless remote induction of shear waves in soft tissues using a transcranial magnetic stimulation device

Science.gov (United States)

Grasland-Mongrain, Pol; Miller-Jolicoeur, Erika; Tang, An; Catheline, Stefan; Cloutier, Guy

2016-03-01

This study presents the first observation of shear waves induced remotely within soft tissues. It was performed through the combination of a transcranial magnetic stimulation device and a permanent magnet. A physical model based on Maxwell and Navier equations was developed. Experiments were performed on a cryogel phantom and a chicken breast sample. Using an ultrafast ultrasound scanner, shear waves of respective amplitudes of 5 and 0.5 μm were observed. Experimental and numerical results were in good agreement. This study constitutes the framework of an alternative shear wave elastography method.

Tissue effects of Ho:YAG laser with varying fluences and pulse widths

Science.gov (United States)

Vari, Sandor G.; van der Veen, Maurits J.; Pergadia, Vani R.; Shi, Wei-Qiang; Duffy, J. T.; Weiss, Andrew B.; Fishbein, Michael C.; Grundfest, Warren S.

1994-02-01

We investigated the effect of varying fluence and pulse width on the ablation rate and consequent thermal damage of the Ho:YAG (2.130 micrometers ) laser. The rate of ablation on fresh bovine knee joint tissues, fibrous cartilage, hyaline cartilage, and bone in saline was determined after varying the fluence (160 - 640 J/cm2) and pulse width (150, 250, 450 microsecond(s) ec, FWHM) at a repetition rate of 2 Hz. A 400/440 micrometers fiber was used. The ablation rate increased linearly with the fluence. In fibrocartilage, different pulse durations generated significant changes in the ablation rates, but showed minor effects on hyaline cartilage and bone. The heat of ablation for all three tissue types decreased after lengthening the pulse.

Generation of spin waves by a train of fs-laser pulses: a novel approach for tuning magnon wavelength.

Science.gov (United States)

Savochkin, I V; Jäckl, M; Belotelov, V I; Akimov, I A; Kozhaev, M A; Sylgacheva, D A; Chernov, A I; Shaposhnikov, A N; Prokopov, A R; Berzhansky, V N; Yakovlev, D R; Zvezdin, A K; Bayer, M

2017-07-18

Currently spin waves are considered for computation and data processing as an alternative to charge currents. Generation of spin waves by ultrashort laser pulses provides several important advances with respect to conventional approaches using microwaves. In particular, focused laser spot works as a point source for spin waves and allows for directional control of spin waves and switching between their different types. For further progress in this direction it is important to manipulate with the spectrum of the optically generated spin waves. Here we tackle this problem by launching spin waves by a sequence of femtosecond laser pulses with pulse interval much shorter than the relaxation time of the magnetization oscillations. This leads to the cumulative phenomenon and allows us to generate magnons in a specific narrow range of wavenumbers. The wavelength of spin waves can be tuned from 15 μm to hundreds of microns by sweeping the external magnetic field by only 10 Oe or by slight variation of the pulse repetition rate. Our findings expand the capabilities of the optical spin pump-probe technique and provide a new method for the spin wave generation and control.

Kinetic Monte Carlo simulations of travelling pulses and spiral waves in the lattice Lotka-Volterra model.

Science.gov (United States)

Makeev, Alexei G; Kurkina, Elena S; Kevrekidis, Ioannis G

2012-06-01

Kinetic Monte Carlo simulations are used to study the stochastic two-species Lotka-Volterra model on a square lattice. For certain values of the model parameters, the system constitutes an excitable medium: travelling pulses and rotating spiral waves can be excited. Stable solitary pulses travel with constant (modulo stochastic fluctuations) shape and speed along a periodic lattice. The spiral waves observed persist sometimes for hundreds of rotations, but they are ultimately unstable and break-up (because of fluctuations and interactions between neighboring fronts) giving rise to complex dynamic behavior in which numerous small spiral waves rotate and interact with each other. It is interesting that travelling pulses and spiral waves can be exhibited by the model even for completely immobile species, due to the non-local reaction kinetics.

Identification of photoacoustic transients during pulsed laser ablation of the human temporal bone: an experimental model.

Science.gov (United States)

Wong, B J; Dickinson, M R; Berns, M W; Neev, J

1996-12-01

Laser ablation of hard tissues during neurotologic operations has been accomplished with continuous-wave (CW) lasers in the visible and midinfrared spectrum. The mechanism of ablation at these wavelengths is secondary to photothermal-induced tissue destruction. As a result, significant thermal damage to surrounding tissue may occur. Pulsed ultraviolet (UV) lasers have been suggested as an alternative to the argon, KTP-532, and CO2 lasers currently used in clinical practice. The pulse length of Excimer lasers are considerably shorter than the thermal diffusion time of bone tissue, and as a consequence thermal injury is minimal. This makes pulsed lasers an attractive tool for tissue ablation in the ear: in essence a "cold knife." However, the short pulse width of Excimer lasers (typically 10-150 ns) can create large thermoelastic stresses in the ablation specimen. This study identifies the presence of these photoacoustic waves during the Excimer laser treatment of the cadaveric human temporal bone. A XeCl (lambda = 308 nm, tau p = 12 ns) excimer laser was used to ablate hard tissue surrounding the oval window and facial ridge with energies of 75, 45, 25, and 12 mJ/pulse. Spot size was estimated to be 0.5 mm2. Custom high-frequency polyvinyldifluoride (PVDF) piezoelectric film transducers were fabricated and attached to the promontory, round window niche, and facial ridges. The signals were amplified using a low-noise preamplifier and recorded on a digitizing oscilloscope. Photoacoustic waves were clearly identified. Notably, large acoustic waves were measured on the promontory and on both sides of the facial ridge. The implications and clinical relevance of these findings is discussed and compared to findings obtained from a model system.

Comparative performance analysis of combined-cycle pulse detonation turbofan engines (PDTEs

Directory of Open Access Journals (Sweden)

Sudip Bhattrai

2013-09-01

Full Text Available Combined-cycle pulse detonation engines are promising contenders for hypersonic propulsion systems. In the present study, design and propulsive performance analysis of combined-cycle pulse detonation turbofan engines (PDTEs is presented. Analysis is done with respect to Mach number at two consecutive modes of operation: (1 Combined-cycle PDTE using a pulse detonation afterburner mode (PDA-mode and (2 combined-cycle PDTE in pulse detonation ramjet engine mode (PDRE-mode. The performance of combined-cycle PDTEs is compared with baseline afterburning turbofan and ramjet engines. The comparison of afterburning modes is done for Mach numbers from 0 to 3 at 15.24 km altitude conditions, while that of pulse detonation ramjet engine (PDRE is done for Mach 1.5 to Mach 6 at 18.3 km altitude conditions. The analysis shows that the propulsive performance of a turbine engine can be greatly improved by replacing the conventional afterburner with a pulse detonation afterburner (PDA. The PDRE also outperforms its ramjet counterpart at all flight conditions considered herein. The gains obtained are outstanding for both the combined-cycle PDTE modes compared to baseline turbofan and ramjet engines.

Phase-coded multi-pulse technique for ultrasonic high-order harmonic imaging of biological tissues in vitro

International Nuclear Information System (INIS)

Ma Qingyu; Zhang Dong; Gong Xiufen; Ma Yong

2007-01-01

Second or higher order harmonic imaging shows significant improvement in image clarity but is degraded by low signal-noise ratio (SNR) compared with fundamental imaging. This paper presents a phase-coded multi-pulse technique to provide the enhancement of SNR for the desired high-order harmonic ultrasonic imaging. In this technique, with N phase-coded pulses excitation, the received Nth harmonic signal is enhanced by 20 log 10 N dB compared with that in the single-pulse mode, whereas the fundamental and other order harmonic components are efficiently suppressed to reduce image confusion. The principle of this technique is theoretically discussed based on the theory of the finite amplitude sound waves, and examined by measurements of the axial and lateral beam profiles as well as the phase shift of the harmonics. In the experimental imaging for two biological tissue specimens, a plane piston source at 2 MHz is used to transmit a sequence of multiple pulses with equidistant phase shift. The second to fifth harmonic images are obtained using this technique with N = 2 to 5, and compared with the images obtained at the fundamental frequency. Results demonstrate that this technique of relying on higher order harmonics seems to provide a better resolution and contrast of ultrasonic images

Terahertz pulse imaging in reflection geometry of human skin cancer and skin tissue

International Nuclear Information System (INIS)

Woodward, Ruth M; Cole, Bryan E; Wallace, Vincent P; Pye, Richard J; Arnone, Donald D; Linfield, Edmund H; Pepper, Michael

2002-01-01

We demonstrate the application of terahertz pulse imaging (TPI) in reflection geometry for the study of skin tissue and related cancers both in vitro and in vivo. The sensitivity of terahertz radiation to polar molecules, such as water, makes TPI suitable for studying the hydration levels in the skin and the determination of the lateral spread of skin cancer pre-operatively. By studying the terahertz pulse shape in the time domain we have been able to differentiate between diseased and normal tissue for the study of basal cell carcinoma (BCC). Basal cell carcinoma has shown a positive terahertz contrast, and inflammation and scar tissue a negative terahertz contrast compared to normal tissue. In vivo measurements on the stratum corneum have enabled visualization of the stratum corneum-epidermis interface and the study of skin hydration levels. These results demonstrate the potential of terahertz pulse imaging for the study of skin tissue and its related disorders, both in vitro and in vivo

Propagation characteristics of laser-induced stress wave in deep tissue for gene transfer

International Nuclear Information System (INIS)

Ando, Takahiro; Sato, Shunichi; Takano, Shinta; Ashida, Hiroshi; Obara, Minoru

2009-01-01

Propagation characteristics of laser-induced stress waves (LISWs) in tissue and their correlation with properties of gene transfection were investigated for targeted deep-tissue gene therapy. LISWs were generated by irradiating a laser-absorbing material with 532-nm Q-switched Nd:YAG laser pulses; a transparent plastic sheet was attached on the absorbing material for plasma confinement. Temporal pressure profiles of LISWs that were propagated through different thickness tissues were measured with a needle-type hydrophone and propagation of LISWs in water was visualized by shadowgraph technique. The measurements showed that at a laser fluence of 1.2 J/cm 2 with a laser spot diameter of 3 mm, flat wavefront was maintained for up to 5 mm in depth and peak pressure P decreased with increasing tissue thickness d; P was proportional to d -0.54 . Rat dorsal skin was injected with plasmid DNA coding for reporter gene, on which different numbers of excised skin(s) was/were placed, and LISWs were applied from the top of the skins. Efficient gene expression was observed in the skin under the 3 mm thick stacked skins, suggesting that deep-located tissue such as muscle can be transfected by transcutaneous application of LISWs.

Steering dissociation of Br2 molecules with two femtosecond pulses via wave packet interference.

Science.gov (United States)

Han, Yong-Chang; Yuan, Kai-Jun; Hu, Wen-Hui; Yan, Tian-Min; Cong, Shu-Lin

2008-04-07

The dissociation dynamics of Br2 molecules induced by two femtosecond pump pulses are studied based on the calculation of time-dependent quantum wave packet. Perpendicular transition from X 1Sigma g+ to A 3Pi 1u+ and 1Pi 1u+ and parallel transition from X 1Sigma g+ to B 3Pi 0u+, involving two product channels Br (2P3/2)+Br (2P3/2) and Br (2P3/2)+Br* (2P1/2), respectively, are taken into account. Two pump pulses create dissociating wave packets interfering with each other. By varying laser parameters, the interference of dissociating wave packets can be controlled, and the dissociation probabilities of Br2 molecules on the three excited states can be changed to different degrees. The branching ratio of Br*/(Br+Br*) is calculated as a function of pulse delay time and phase difference.

Ionization waves in the pre-breakdown phase of a pulsed capillary discharge

International Nuclear Information System (INIS)

Favre, M.; Lenero, A.M.; Chuaqui, H.; Mitchell, I.; Wyndham, E.; Choi, P.; Dumitrescu, C.; Mond, M.; Rutkevich, I.; Kaufman, Y.

2001-01-01

We present experimental observations of ionization waves in pulsed hollow cathode capillary discharges. When the capillary shield is at the anode potential, an anode directed ionization wave, with characteristic speed ∼10 7 m/s, is observed. When the capillary shield is at the cathode potential, a cathode directed slower ionization wave, with characteristic speed ∼10 4 m/s, is observed. The several orders of magnitude difference in the ionization wave speed can be attributed to the different initial electric field configuration in both polarities

Comparison of acoustic shock waves generated by micro and nanosecond lasers for a smart laser surgery system

Science.gov (United States)

Nguendon Kenhagho, Hervé K.; Rauter, Georg; Guzman, Raphael; C. Cattin, Philippe; Zam, Azhar

2018-02-01

Characterization of acoustic shock wave will guarantee efficient tissue differentiation as feedback to reduce the probability of undesirable damaging (i.e. cutting) of tissues in laser surgery applications. We ablated hard (bone) and soft (muscle) tissues using a nanosecond pulsed Nd:YAG laser at 532 nm and a microsecond pulsed Er:YAG laser at 2.94 μm. When the intense short ns-pulsed laser is applied to material, the energy gain causes locally a plasma at the ablated spot that expands and propagates as an acoustic shock wave with a rarefaction wave behind the shock front. However, when using a μs-pulsed Er:YAG laser for material ablation, the acoustic shock wave is generated during the explosion of the ablated material. We measured and compared the emitted acoustic shock wave generated by a ns-pulsed Nd:YAG laser and a μs-pulsed Er:YAG laser measured by a calibrated microphone. As the acoustic shock wave attenuates as it propagates through air, the distance between ablation spots and a calibrated microphone was at 5 cm. We present the measurements on the propagation characteristics of the laser generated acoustic shock wave by measuring the arrival time-of-flight with a calibrated microphone and the energy-dependent evolution of acoustic parameters such as peak-topeak pressure, the ratio of the peak-to-peak pressures for the laser induced breakdown in air, the ablated muscle and the bone, and the spectral energy.

Combination of Echocardiography and Pulse Wave Velocity Provides Clues for the Differentiation between White Coat Hypertension and Hypertension in Postmenopausal Women.

Science.gov (United States)

Suzuki, Hiromichi; Kobayashi, Kazuhiro; Okada, Hirokazu

2014-05-01

To determine whether or not noninvasive assessment of the cardiovascular system can discriminate white coat hypertension and hypertension in postmenopausal women. The major reason is the high prevalence of white coat hypertension in these subjects and the uncertain associations of white coat hypertension with cardiovascular risk. Selected women were required to be naturally or surgically menopausal for at least 1 year but not more than 5 years past their menstrual period. White coat hypertension patients were defined as subjects who had office blood pressures >150/90 mm Hg but who had both systolic and diastolic ambulatory pressures coat hypertension based on the criteria in the trial. Pulse wave patterns were different between subjects with white coat hypertension and those with hypertension. PWV of subjects with white coat hypertension was 1.32 ± 0.33 m/s and that of patients with hypertension was 1.46 ± 0.37 m/s (p coat hypertension could be easily differentiated from hypertension. The combination of blood pressure self-monitoring, echocardiographic data, and PWV can be a powerful indicator for the treatment of hypertension in postmenopausal women.

Shock waves in water at low energy pulsed electric discharges

International Nuclear Information System (INIS)

Pinchuk, M E; Kolikov, V A; Rutberg, Ph G; Leks, A G; Dolinovskaya, R V; Snetov, V N; Stogov, A Yu

2012-01-01

Experimental results of shock wave formation and propagation in water at low energy pulsed electric discharges are presented. To study the hydrodynamic structure of the shock waves, the direct shadow optical diagnostic device with time resolution of 5 ns and spatial resolution of 0.1 mm was designed and developed. Synchronization of the diagnostic and electrodischarge units by the fast optocouplers was carried out. The dependences of shock wave velocities after breakdown of interelectrode gap for various energy inputs (at range of ≤1 J) into discharge were obtained. Based on the experimental results the recommendations for the adjustment parameters of the power supply and load were suggested.

Pulsed Traveling-wave Quadrature Squeezing Using Quasi-phase Matched Lithium Niobate Crystals

Science.gov (United States)

Chen, Chao-Hsiang

Interests in generating higher quantum noise squeezing in order to develop methods to enhance optical measurement below the shot-noise limit in various applications has grown in recent years. The noise suppression from squeezing can improve the SNR in coherent optical systems when the returning signal power is weak, such as optical coherence tomography, LADAR, confocal microscopy and low-light coherent imaging. Unlike the generation of squeezing with a continuous wave, which is currently developed mainly for gravitational wave detection in LIGO project, the study of pulsed-traveling waves is focused on industrial, medical and other commercial interests. This dissertation presents the experimental results of pulsed traveling wave squeezing. The intention of the study is to explore the possibility of using quasi-phase matched crystals to generate the highest possible degree of quadrature squeezing. In order to achieve this goal, efforts to test the various effects from spatial Gaussian modes and relative beam waist placement for the second-harmonic pump were carried out in order to further the understanding of limiting factors to pulsed traveling wave squeezing. 20mm and 30mm-long periodically poled lithium noibate (PPLN) crystals were used in the experiment to generate a squeezed vacuum state. A maximum of 4.2+/-0.2dB quadrature squeezing has been observed, and the measured anti-squeezing exceeds 20dB.The phase sensitive amplification (PSA) gain and de-gain performance were also measured to compare the results of measured squeezing. The PPLN crystals can produce high conversion efficiency of second-harmonic generation (SHG) without a cavity. When a long PPLN crystal is used in a squeezer, the beam propagation in the nonlinear medium does not follow the characteristics in thin crystals. Instead, it is operated under the long-crystal criteria, which the crystal length is multiple times longer than the Rayleigh range of the injected beam i n the crystals. Quasi

Effect of pulse-wave factors in Middle Aged Women by Mountain Cultivated Ginseng Pharmacopuncture Original Articles

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Park Sang Wook

2011-03-01

Full Text Available Objectives: The aim of this experiment is to know about Effect of pulse-wave factors in Middle Aged Women by Mountain Cultivated Ginseng Pharmacopuncture. Methods: First 20 Middle Aged women are diagnosed by pulse diagnosis, and then Mountain Cultivated Ginseng Pharmacopuncture(1 injection 20cc were injected. 30 minutes later, pulse diagnosis again performed. As a result, method of one-group pretest-posttes design were used for evaluation. Results: T(Total pulse cycle time statistically significant increased on both left and right chon, kwan,cheok. T4 time statistically significant increased on both left and right chon, kwan, cheok. T4-T1/T indexs except left cheokmaek, Right cheokmaek observation area decreased significantly in four sites.Wm(indicating high pressure retention time indexs increased significantly in the five sites were observed except right chon maek. Conclusions: Effect of pulse-wave factors in Middle Aged Women by Mountain Cultivated Ginseng Pharmacopuncture increased T, T4, Wm and decreased T4-T1/T indexs. The results of this experiment,Mountain Cultivated Ginseng Pharmacopuncture induced to increase the Pulse-wave's stability and strength.

Traveling waves in a spatially-distributed Wilson-Cowan model of cortex: From fronts to pulses

Science.gov (United States)

Harris, Jeremy D.; Ermentrout, Bard

2018-04-01

Wave propagation in excitable media has been studied in various biological, chemical, and physical systems. Waves are among the most common evoked and spontaneous organized activity seen in cortical networks. In this paper, we study traveling fronts and pulses in a spatially-extended version of the Wilson-Cowan equations, a neural firing rate model of sensory cortex having two population types: Excitatory and inhibitory. We are primarily interested in the case when the local or space-clamped dynamics has three fixed points: (1) a stable down state; (2) a saddle point with stable manifold that acts as a threshold for firing; (3) an up state having stability that depends on the time scale of the inhibition. In the case when the up state is stable, we look for wave fronts, which transition the media from a down to up state, and when the up state is unstable, we are interested in pulses, a transient increase in firing that returns to the down state. We explore the behavior of these waves as the time and space scales of the inhibitory population vary. Some interesting findings include bistability between a traveling front and pulse, fronts that join the down state to an oscillation or spatiotemporal pattern, and pulses which go through an oscillatory instability.

Hypericin and pulsed laser therapy of squamous cell cancer in vitro.

Science.gov (United States)

Bublik, Michael; Head, Christian; Benharash, Peyman; Paiva, Marcos; Eshraghi, Adrian; Kim, Taiho; Saxton, Romaine

2006-06-01

This in vitro study compares continuous wave and pulsed laser light at longer wavelengths for activation of the phototoxic drug hypericin in human cancer cells. Two-photon pulsed laser light now allows high-resolution fluorescent imaging of cancer cells and should provide deeper tissue penetration with near infrared light for improved detection as well as phototoxicity in human tumors. Cultured Seoul National University (SNU)-1 tumor cells from a squamous cell carcinoma (SCC) were incubated with hypericin before photoirradiation at four laser wavelengths. Phototoxicity of hypericin sensitized SCC cells was measured by dimethyl thiazoldiphenyl (MTT) tetrazolium bromide cell viability assays and by confocal fluorescence microscopy via 532-nm and infrared two-photon pulsed laser light. Phototoxic response increased linearly with hypericin dose of 0.1-2 microM, light exposure time of 5-120 sec, and pulsed dye laser wavelengths of 514-593 nm. Light energy delivery for 50% cell phototoxicity (LD50) response was 9 joules at 514 nm, 3 joules at 550 nm, and less than 1 joule at the 593 nm hypericin light absorption maxima. Fluorescence confocal microscopy revealed membrane and perinuclear localization of hypericin in the SNU cells with membrane damage seen after excitation with visible 532 nm continuous wave light or two-photon 700-950 nm picosecond pulsed laser irradiation. Hypericin may be a powerful tumor targetting drug when combined with pulsed laser light in patients with recurrent head and neck SCC.

Numerical simulation of ultrasound-thermotherapy combining nonlinear wave propagation with broadband soft-tissue absorption.

Science.gov (United States)

Ginter, S

2000-07-01

Ultrasound (US) thermotherapy is used to treat tumours, located deep in human tissue, by heat. It features by the application of high intensity focused ultrasound (HIFU), high local temperatures of about 90 degrees C and short treating time of a few seconds. Dosage of the therapy remains a problem. To get it under control, one has to know the heat source, i.e. the amount of absorbed US power, which shows nonlinear influences. Therefore, accurate simulations are essential. In this paper, an improved simulation model is introduced which enables accurate investigations of US thermotherapy. It combines nonlinear US propagation effects, which lead to generation of higher harmonics, with a broadband frequency-power law absorption typical for soft tissue. Only the combination of both provides a reliable calculation of the generated heat. Simulations show the influence of nonlinearities and broadband damping for different source signals on the absorbed US power density distribution.

Effect of Shock Waves Generated by Pulsed Electric Discharges in Water on Yeast Cells and Virus Particles

Science.gov (United States)

Girdyuk, A. E.; Gorshkov, A. N.; Egorov, V. V.; Kolikov, V. A.; Snetov, V. N.; Shneerson, G. A.

2018-02-01

The aim of this study is to determine the optimal parameters of the electric pulses and shock waves generated by them for the soft destruction of the virus and yeast envelopes with no changes in the structure of antigenic surface albumin and in the cell morphology in order to use them to produce antivirus vaccines and in biotechnology. The pulse electric discharges in water have been studied for different values of amplitude, pulse duration and the rate of the rise in the current. A mathematical model has been developed to estimate the optimal parameters of pulsed electric charges and shock waves for the complete destruction of the yeast cell envelopes and virus particles at a minimum of pulses.

Combining Raman and laser induced breakdown spectroscopy by double pulse lasing.

Science.gov (United States)

Lednev, Vasily N; Pershin, Sergey M; Sdvizhenskii, Pavel A; Grishin, Mikhail Ya; Fedorov, Alexander N; Bukin, Vladimir V; Oshurko, Vadim B; Shchegolikhin, Alexander N

2018-01-01

A new approach combining Raman spectrometry and laser induced breakdown spectrometry (LIBS) within a single laser event was suggested. A pulsed solid state Nd:YAG laser running in double pulse mode (two frequency-doubled sequential nanosecond laser pulses with dozens microseconds delay) was used to combine two spectrometry methods within a single instrument (Raman/LIBS spectrometer). First, a low-energy laser pulse (power density far below ablation threshold) was used for Raman measurements while a second powerful laser pulse created the plasma suitable for LIBS analysis. A short time delay between two successive pulses allows measuring LIBS and Raman spectra at different moments but within a single laser flash-lamp pumping. Principal advantages of the developed instrument include high quality Raman/LIBS spectra acquisition (due to optimal gating for Raman/LIBS independently) and absence of target thermal alteration during Raman measurements. A series of high quality Raman and LIBS spectra were acquired for inorganic salts (gypsum, anhydrite) as well as for pharmaceutical samples (acetylsalicylic acid). To the best of our knowledge, the quantitative analysis feasibility by combined Raman/LIBS instrument was demonstrated for the first time by calibration curves construction for acetylsalicylic acid (Raman) and copper (LIBS) in gypsum matrix. Combining ablation pulses and Raman measurements (LIBS/Raman measurements) within a single instrument makes it an efficient tool for identification of samples hidden by non-transparent covering or performing depth profiling analysis including remote sensing. Graphical abstract Combining Raman and laser induced breakdown spectroscopy by double pulse lasing.

Increasing accuracy of pulse transit time measurements by automated elimination of distorted photoplethysmography waves

NARCIS (Netherlands)

M.H.N. van Velzen (M. H N); A.J. Loeve (Arjo J.); S.P. Niehof (Sjoerd); E.G. Mik (Egbert)

2017-01-01

textabstractPhotoplethysmography (PPG) is a widely available non-invasive optical technique to visualize pressure pulse waves (PWs). Pulse transit time (PTT) is a physiological parameter that is often derived from calculations on ECG and PPG signals and is based on tightly defined characteristics of

Pulse picker for synchrotron radiation driven by a surface acoustic wave.

Science.gov (United States)

Vadilonga, Simone; Zizak, Ivo; Roshchupkin, Dmitry; Petsiuk, Andrei; Dolbnya, Igor; Sawhney, Kawal; Erko, Alexei

2017-05-15

A functional test for a pulse picker for synchrotron radiation was performed at Diamond Light Source. The purpose of a pulse picker is to select which pulse from the synchrotron hybrid-mode bunch pattern reaches the experiment. In the present work, the Bragg reflection on a Si/B4C multilayer was modified using surface acoustic wave (SAW) trains. Diffraction on the SAW alters the direction of the x rays and it can be used to modulate the intensity of the x rays that reach the experimental chamber. Using electronic modulation of the SAW amplitude, it is possible to obtain different scattering conditions for different x-ray pulses. To isolate the single bunch, the state of the SAW must be changed in the short time gap between the pulses. To achieve the necessary time resolution, the measurements have been performed in conical diffraction geometry. The achieved time resolution was 120 ns.

Heat transfer modelling of pulsed laser-tissue interaction

Science.gov (United States)

Urzova, J.; Jelinek, M.

2018-03-01

Due to their attributes, the application of medical lasers is on the rise in numerous medical fields. From a biomedical point of view, the most interesting applications are the thermal interactions and the photoablative interactions, which effectively remove tissue without excessive heat damage to the remaining tissue. The objective of this work is to create a theoretical model for heat transfer in the tissue following its interaction with the laser beam to predict heat transfer during medical laser surgery procedures. The dimensions of the ablated crater (shape and ablation depth) were determined by computed tomography imaging. COMSOL Multiphysics software was used for temperature modelling. The parameters of tissue and blood, such as density, specific heat capacity, thermal conductivity and diffusivity, were calculated from the chemical ratio. The parameters of laser-tissue interaction, such as absorption and reflection coefficients, were experimentally determined. The parameters of the laser beam were power density, repetition frequency, pulse length and spot dimensions. Heat spreading after laser interaction with tissue was captured using a Fluke thermal camera. The model was verified for adipose tissue, skeletal muscle tissue and heart muscle tissue.

UWB pulse propagation into human tissues

International Nuclear Information System (INIS)

Cavagnaro, Marta; Pittella, Erika; Pisa, Stefano

2013-01-01

In this paper the propagation of a UWB pulse into a layered model of the human body is studied to characterize absorption and reflection of the UWB signal due to the different body tissues. Several time behaviours for the incident UWB pulse are considered and compared with reference to the feasibility of breath and heartbeat activity monitoring. Results show that if the UWB source is placed far from the human body, the reflection coming from the interface between air and skin can be used to detect the respiratory activity. On the contrary, if the UWB source is placed close to the human body, a small reflection due to the interface between the posterior lung wall and the bone, which is well distanced in time from the reflections due to the first layers of the body model, can be used to detect lung and heart changes associated with the cardio-respiratory activity. (paper)

Probability of cavitation for single ultrasound pulses applied to tissues and tissue-mimicking materials.

Science.gov (United States)

Maxwell, Adam D; Cain, Charles A; Hall, Timothy L; Fowlkes, J Brian; Xu, Zhen

2013-03-01

In this study, the negative pressure values at which inertial cavitation consistently occurs in response to a single, two-cycle, focused ultrasound pulse were measured in several media relevant to cavitation-based ultrasound therapy. The pulse was focused into a chamber containing one of the media, which included liquids, tissue-mimicking materials, and ex vivo canine tissue. Focal waveforms were measured by two separate techniques using a fiber-optic hydrophone. Inertial cavitation was identified by high-speed photography in optically transparent media and an acoustic passive cavitation detector. The probability of cavitation (P(cav)) for a single pulse as a function of peak negative pressure (p(-)) followed a sigmoid curve, with the probability approaching one when the pressure amplitude was sufficient. The statistical threshold (defined as P(cav) = 0.5) was between p(-) = 26 and 30 MPa in all samples with high water content but varied between p(-) = 13.7 and >36 MPa in other media. A model for radial cavitation bubble dynamics was employed to evaluate the behavior of cavitation nuclei at these pressure levels. A single bubble nucleus with an inertial cavitation threshold of p(-) = 28.2 megapascals was estimated to have a 2.5 nm radius in distilled water. These data may be valuable for cavitation-based ultrasound therapy to predict the likelihood of cavitation at various pressure levels and dimensions of cavitation-induced lesions in tissue. Copyright © 2013 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

An analysis of beam parameters on proton-acoustic waves through an analytic approach.

Science.gov (United States)

Kipergil, Esra Aytac; Erkol, Hakan; Kaya, Serhat; Gulsen, Gultekin; Unlu, Mehmet Burcin

2017-06-21

It has been reported that acoustic waves are generated when a high-energy pulsed proton beam is deposited in a small volume within tissue. One possible application of proton-induced acoustics is to get real-time feedback for intra-treatment adjustments by monitoring such acoustic waves. A high spatial resolution in ultrasound imaging may reduce proton range uncertainty. Thus, it is crucial to understand the dependence of the acoustic waves on the proton beam characteristics. In this manuscript, firstly, an analytic solution for the proton-induced acoustic wave is presented to reveal the dependence of the signal on the beam parameters; then it is combined with an analytic approximation of the Bragg curve. The influence of the beam energy, pulse duration and beam diameter variation on the acoustic waveform are investigated. Further analysis is performed regarding the Fourier decomposition of the proton-acoustic signals. Our results show that the smaller spill time of the proton beam upsurges the amplitude of the acoustic wave for a constant number of protons, which is hence beneficial for dose monitoring. The increase in the energy of each individual proton in the beam leads to the spatial broadening of the Bragg curve, which also yields acoustic waves of greater amplitude. The pulse duration and the beam width of the proton beam do not affect the central frequency of the acoustic wave, but they change the amplitude of the spectral components.

Plasma luminescence feedback control system for precise ultrashort pulse laser tissue ablation

Science.gov (United States)

Kim, Beop-Min; Feit, Michael D.; Rubenchik, Alexander M.; Gold, David M.; Darrow, Christopher B.; Marion, John E., II; Da Silva, Luiz B.

1998-05-01

Plasma luminescence spectroscopy was used for precise ablation of bone tissue without damaging nearby soft tissue using an ultrashort pulse laser. Strong contrast of the luminescence spectra between bone marrow and spinal cord provided the real time feedback control so bone tissue is selectively ablated while preserving the spinal cord.

Increasing accuracy of pulse transit time measurements by automated elimination of distorted photoplethysmography waves

NARCIS (Netherlands)

van Velzen, M.H.N.; Loeve, A.J.; Niehof, S.P.; Mik, E.G.

2017-01-01

Photoplethysmography (PPG) is a widely available non-invasive optical technique to visualize pressure pulse waves (PWs). Pulse transit time (PTT) is a physiological parameter that is often derived from calculations on ECG and PPG signals and is based on tightly defined characteristics of the PW

Models of brachial to finger pulse wave distortion and pressure decrement

NARCIS (Netherlands)

Gizdulich, P.; Prentza, A.; Wesseling, K.H.

1997-01-01

Objective: To model the pulse wave distortion and pressure decrement occurring between brachial and finger arteries. Distortion reversion and decrement correction were also our aims. Methods: Brachial artery pressure was recorded intra-arterially and finger pressure was recorded non-invasively by

Putative photoacoustic damage in skin induced by pulsed ArF excimer laser

Energy Technology Data Exchange (ETDEWEB)

Watanabe, S.; Flotte, T.J.; McAuliffe, D.J.; Jacques, S.L.

1988-05-01

Argon-fluoride excimer laser ablation of guinea pig stratum corneum causes deeper tissue damage than expected for thermal or photochemical mechanisms, suggesting that photoacoustic waves have a role in tissue damage. Laser irradiation (193 nm, 14-ns pulse) at two different radiant exposures, 62 and 156 mJ/cm2 per pulse, was used to ablate the 15-microns-thick stratum corneum of the skin. Light and electron microscopy of immediate biopsies demonstrated damage to fibroblasts as deep as 88 and 220 microns, respectively, below the ablation site. These depths are far in excess of the optical penetration depth of 193-nm light (1/e depth = 1.5 micron). The damage is unlikely to be due to a photochemical mechanism because (a) the photons will not penetrate to these depths, (b) it is a long distance for toxic photoproducts to diffuse, and (c) damage is proportional to laser pulse intensity and not the total dose that accumulates in the residual tissue; therefore, reciprocity does not hold. Damage due to a thermal mechanism is not expected because there is not sufficient energy deposited in the tissue to cause significant heating at such depths. The damage is most likely due to a photoacoustic mechanism because (a) photoacoustic waves can propagate deep into tissue, (b) the depth of damage increases with increasing laser pulse intensity rather than with increasing total residual energy, and (c) the effects are immediate. These effects should be considered in the evaluation of short pulse, high peak power laser-tissue interactions.

Nonlinear side effects of fs pulses inside corneal tissue during photodisruption

Science.gov (United States)

Heisterkamp, A.; Ripken, T.; Mamom, T.; Drommer, W.; Welling, H.; Ertmer, W.; Lubatschowski, H.

In order to evaluate the potential for refractive surgery, fs laser pulses of 150-fs pulse duration were used to process corneal tissue of dead and living animal eyes. By focusing the laser radiation down to spot sizes of several microns, very precise cuts could be achieved inside the treated cornea, accompanied with minimum collateral damage to the tissue by thermal or mechanical effects. During histo-pathological analysis by light and transmission electron microscopy considerable side effects of fs photodisruption were found. Due to the high intensities at the focal region several nonlinear effects occurred. Self-focusing, photodissociation, UV-light production were observed, leading to streak formation inside the cornea.

Influence of laser-supported detonation waves on metal drilling with pulsed CO2 lasers

International Nuclear Information System (INIS)

Stuermer, E.; von Allmen, M.

1978-01-01

Drilling of highly reflective metals in an ambient atmosphere with single TEA-CO 2 -laser pulses of fluences between 300 and 6000 J/cm 2 is reported. The drilling process was investigated by measuring the time-resolved laser power reflected specularly from the targets during the interaction and by analyzing the craters produced. Experiments were performed in ambient air, argon, and helium. Target damage was found to be strongly influenced by a laser-supported detonation (LSD) wave in the ambient gas. If the laser fluence exceeded a material-dependent damage threshold (copper: 300 J/cm 2 ), drilling occurred, but the efficiency was inversely related to the duration of the LSD wave. Efficient material removal is possible if the LSD wave can be dissipated within a small fraction of the laser pulse duration. This was achieved by small-F-number focusing of TEM 00 laser pulses of 5-μs duration. Replacing the ambient air at the target by a gas of lower density results in a further significant reduction of LSD-wave lifetime, and a correlated increase of the drilling yield. On copper targets a maximum drilling yield of 10 -5 cm 3 /J was observed in ambient helium at a laser fluence of 1 kJ/cm 2

Acoustic radiation force impulse elastography of the kidneys: is shear wave velocity affected by tissue fibrosis or renal blood flow?

Science.gov (United States)

Asano, Kenichiro; Ogata, Ai; Tanaka, Keiko; Ide, Yoko; Sankoda, Akiko; Kawakita, Chieko; Nishikawa, Mana; Ohmori, Kazuyoshi; Kinomura, Masaru; Shimada, Noriaki; Fukushima, Masaki

2014-05-01

The aim of this study was to identify the main influencing factor of the shear wave velocity (SWV) of the kidneys measured by acoustic radiation force impulse elastography. The SWV was measured in the kidneys of 14 healthy volunteers and 319 patients with chronic kidney disease. The estimated glomerular filtration rate was calculated by the serum creatinine concentration and age. As an indicator of arteriosclerosis of large vessels, the brachial-ankle pulse wave velocity was measured in 183 patients. Compared to the degree of interobserver and intraobserver deviation, a large variance of SWV values was observed in the kidneys of the patients with chronic kidney disease. Shear wave velocity values in the right and left kidneys of each patient correlated well, with high correlation coefficients (r = 0.580-0.732). The SWV decreased concurrently with a decline in the estimated glomerular filtration rate. A low SWV was obtained in patients with a high brachial-ankle pulse wave velocity. Despite progression of renal fibrosis in the advanced stages of chronic kidney disease, these results were in contrast to findings for chronic liver disease, in which progression of hepatic fibrosis results in an increase in the SWV. Considering that a high brachial-ankle pulse wave velocity represents the progression of arteriosclerosis in the large vessels, the reduction of elasticity succeeding diminution of blood flow was suspected to be the main influencing factor of the SWV in the kidneys. This study indicates that diminution of blood flow may affect SWV values in the kidneys more than the progression of tissue fibrosis. Future studies for reducing data variance are needed for effective use of acoustic radiation force impulse elastography in patients with chronic kidney disease.

Allowable propagation of short pulse laser beam in a plasma channel and electromagnetic solitary waves

International Nuclear Information System (INIS)

Zhang, Shan; Hong, Xue-Ren; Wang, Hong-Yu; Xie, Bai-Song

2011-01-01

Nonparaxial and nonlinear propagation of a short intense laser beam in a parabolic plasma channel is analyzed by means of the variational method and nonlinear dynamics. The beam propagation properties are classified by five kinds of behaviors. In particularly, the electromagnetic solitary wave for finite pulse laser is found beside the other four propagation cases including beam periodically oscillating with defocussing and focusing amplitude, constant spot size, beam catastrophic focusing. It is also found that the laser pulse can be allowed to propagate in the plasma channel only when a certain relation for laser parameters and plasma channel parameters is satisfied. For the solitary wave, it may provide an effective way to obtain ultra-short laser pulse.

Evaluation of arterial propagation velocity based on the automated analysis of the Pulse Wave Shape

International Nuclear Information System (INIS)

Clara, F M; Scandurra, A G; Meschino, G J; Passoni, L I

2011-01-01

This paper proposes the automatic estimation of the arterial propagation velocity from the pulse wave raw records measured in the region of the radial artery. A fully automatic process is proposed to select and analyze typical pulse cycles from the raw data. An adaptive neuro-fuzzy inference system, together with a heuristic search is used to find a functional approximation of the pulse wave. The estimation of the propagation velocity is carried out via the analysis of the functional approximation obtained with the fuzzy model. The analysis of the pulse wave records with the proposed methodology showed small differences compared with the method used so far, based on a strong interaction with the user. To evaluate the proposed methodology, we estimated the propagation velocity in a population of healthy men from a wide range of ages. It has been found in these studies that propagation velocity increases linearly with age and it presents a considerable dispersion of values in healthy individuals. We conclude that this process could be used to evaluate indirectly the propagation velocity of the aorta, which is related to physiological age in healthy individuals and with the expectation of life in cardiovascular patients.

Thermomechanical effect of pulse-periodic laser radiation on cartilaginous and eye tissues

Science.gov (United States)

Baum, O. I.; Zheltov, G. I.; Omelchenko, A. I.; Romanov, G. S.; Romanov, O. G.; Sobol, E. N.

2013-08-01

This paper is devoted to theoretical and experimental studies into the thermomechanical action of laser radiation on biological tissues. The thermal stresses and strains developing in biological tissues under the effect of pulse-periodic laser radiation are theoretically modeled for a wide range of laser pulse durations. The models constructed allow one to calculate the magnitude of pressures developing in cartilaginous and eye tissues exposed to laser radiation and predict the evolution of cavitation phenomena occurring therein. The calculation results agree well with experimental data on the growth of pressure and deformations, as well as the dynamics of formation of gas bubbles, in the laser-affected tissues. Experiments on the effect of laser radiation on the trabecular region of the eye in minipigs demonstrated that there existed optimal laser irradiation regimens causing a substantial increase in the hydraulic permeability of the radiation-exposed tissue, which can be used to develop a novel glaucoma treatment method.

Thermomechanical effect of pulse-periodic laser radiation on cartilaginous and eye tissues

International Nuclear Information System (INIS)

Baum, O I; Omelchenko, A I; Sobol, E N; Zheltov, G I; Romanov, G S; Romanov, O G

2013-01-01

This paper is devoted to theoretical and experimental studies into the thermomechanical action of laser radiation on biological tissues. The thermal stresses and strains developing in biological tissues under the effect of pulse-periodic laser radiation are theoretically modeled for a wide range of laser pulse durations. The models constructed allow one to calculate the magnitude of pressures developing in cartilaginous and eye tissues exposed to laser radiation and predict the evolution of cavitation phenomena occurring therein. The calculation results agree well with experimental data on the growth of pressure and deformations, as well as the dynamics of formation of gas bubbles, in the laser-affected tissues. Experiments on the effect of laser radiation on the trabecular region of the eye in minipigs demonstrated that there existed optimal laser irradiation regimens causing a substantial increase in the hydraulic permeability of the radiation-exposed tissue, which can be used to develop a novel glaucoma treatment method. (paper)

Infrared laser damage thresholds in corneal tissue phantoms using femtosecond laser pulses

Science.gov (United States)

Boretsky, Adam R.; Clary, Joseph E.; Noojin, Gary D.; Rockwell, Benjamin A.

2018-02-01

Ultrafast lasers have become a fixture in many biomedical, industrial, telecommunications, and defense applications in recent years. These sources are capable of generating extremely high peak power that can cause laser-induced tissue breakdown through the formation of a plasma upon exposure. Despite the increasing prevalence of such lasers, current safety standards (ANSI Z136.1-2014) do not include maximum permissible exposure (MPE) values for the cornea with pulse durations less than one nanosecond. This study was designed to measure damage thresholds in corneal tissue phantoms in the near-infrared and mid-infrared to identify the wavelength dependence of laser damage thresholds from 1200-2500 nm. A high-energy regenerative amplifier and optical parametric amplifier outputting 100 femtosecond pulses with pulse energies up to 2 mJ were used to perform exposures and determine damage thresholds in transparent collagen gel tissue phantoms. Three-dimensional imaging, primarily optical coherence tomography, was used to evaluate tissue phantoms following exposure to determine ablation characteristics at the surface and within the bulk material. The determination of laser damage thresholds in the near-IR and mid-IR for ultrafast lasers will help to guide safety standards and establish the appropriate MPE levels for exposure sensitive ocular tissue such as the cornea. These data will help promote the safe use of ultrafast lasers for a wide range of applications.

Streak-photographic investigation of shock wave emission after laser-induced plasma formation in water

Science.gov (United States)

Noack, Joachim; Vogel, Alfred

1995-05-01

The shock wave emission after dielectric breakdown in water was investigated to assess potential shock wave effects in plasma mediated tissue ablation and intraocular photodisruption. Of particular interest was the dependence of shock wave pressure as a function of distance from the plasma for different laser pulse energies. We have generated plasmas in water with a Nd:YAG laser system delivering pulses of 6 ns duration. The pulses, with energies between 0.4 and 36 mJ (approximately equals 180 times threshold), were focused into a cuvette containing distilled water. The shock wave was visualized with streak photography combined with a schlieren technique. An important advantage of this technique is that the shock position as a function of time can directly be obtained from a single streak and hence a single event. Other methods (e.g. flash photography or passage time measurements between fixed locations) in contrast rely on reproducible events. Using the shock wave speed obtained from the streak images, shock wave peak pressures were calculated providing detailed information on the propagation of the shock. The shock peak pressure as a function of distance r from the optical axis was found to decrease faster than 1/r2 in regions up to distances of 100-150 micrometers . For larger distances it was found to be roughly proportional to 1/r. The scaling law for maximum shock pressure p, at a given distance was found to be proportional to the square root of the laser pulse energy E for distances of 50-200 micrometers from the optical axis.

Comparison study among conventional, tissue harmonic and pulse inversion harmonic images to evaluate pleural effusion and ascites

International Nuclear Information System (INIS)

Chung, Hwan Hoon; Kim, Yun Hwan; Kang, Chang Ho; Park, Bum Jin; Chung, Kyoo Byung; Suh, Won Hyuck

2000-01-01

To determine the most useful sonographic technique to evaluate pleural effusion and ascites by comparing conventional, tissue harmonic and pulse inversion harmonic images. 12 patients having pleural effusion and 14 patients having ascites were included in this study. 18 patients were male and 8 patients were female. Average age was 54.8 yrs (25-77). We compared images which had been taken at the same section with 3 above mentioned sonographic techniques. Evaluation was done by 3 radiologists in consensus and grades were given to 3 techniques from 1 to 3. Evaluating points were 1) normal structures that border the fluid such as liver, peritoneal lining, pleura, 2) septation in fluid, 3) debris floating in fluid, and 4) artifacts. Pulse inversion harmonic image was the best in image quality for normal structures, followed by tissue harmonic and conventional image (p<0.05). Pulse inversion harmonic image was better than conventional image to evaluate septation in fluid (p<0.05), but there were no statistically significant difference between pulse inversion and tissue harmonic images, and tissue harmonic and conventional images. Tissue harmonic image was better than pulse inversion harmonic and conventional images to evaluate debris floating in fluid (p<0.05) but there was no statistically significant difference between these two latter techniques. Artifacts were most prominent on conventional image followed by tissue harmonic and pulse inversion harmonic image (p<0.05). Pulse inversion harmonic image was the best sonographic technique to evaluate pleural effusion or ascites, However, Tissue harmonic image was the best for evaluation of debris.

Comparison study among conventional, tissue harmonic and pulse inversion harmonic images to evaluate pleural effusion and ascites

Energy Technology Data Exchange (ETDEWEB)

Chung, Hwan Hoon; Kim, Yun Hwan; Kang, Chang Ho; Park, Bum Jin; Chung, Kyoo Byung; Suh, Won Hyuck [Korea University College of Medicine, Seoul (Korea, Republic of)

2000-12-15

To determine the most useful sonographic technique to evaluate pleural effusion and ascites by comparing conventional, tissue harmonic and pulse inversion harmonic images. 12 patients having pleural effusion and 14 patients having ascites were included in this study. 18 patients were male and 8 patients were female. Average age was 54.8 yrs (25-77). We compared images which had been taken at the same section with 3 above mentioned sonographic techniques. Evaluation was done by 3 radiologists in consensus and grades were given to 3 techniques from 1 to 3. Evaluating points were 1) normal structures that border the fluid such as liver, peritoneal lining, pleura, 2) septation in fluid, 3) debris floating in fluid, and 4) artifacts. Pulse inversion harmonic image was the best in image quality for normal structures, followed by tissue harmonic and conventional image (p<0.05). Pulse inversion harmonic image was better than conventional image to evaluate septation in fluid (p<0.05), but there were no statistically significant difference between pulse inversion and tissue harmonic images, and tissue harmonic and conventional images. Tissue harmonic image was better than pulse inversion harmonic and conventional images to evaluate debris floating in fluid (p<0.05) but there was no statistically significant difference between these two latter techniques. Artifacts were most prominent on conventional image followed by tissue harmonic and pulse inversion harmonic image (p<0.05). Pulse inversion harmonic image was the best sonographic technique to evaluate pleural effusion or ascites, However, Tissue harmonic image was the best for evaluation of debris.

Pulse wave velocity in familial combined hyperlipidemia.

NARCIS (Netherlands)

Avest, E. ter; Holewijn, S.; Bredie, S.J.H.; Tits, L.J.H. van; Stalenhoef, A.F.H.; Graaf, J. de

2007-01-01

BACKGROUND: In the present cross-sectional study we investigated whether familial combined hyperlipidemia (FCH) is associated with an increased arterial wall stiffness, and whether measures of arterial wall stiffness in FCH family members could contribute to cardiovascular risk stratification.

Mechanisms of amplification of ultrashort electromagnetic pulses in gyrotron traveling wave tube with helically corrugated waveguide

International Nuclear Information System (INIS)

Ginzburg, N. S.; Zaslavsky, V. Yu.; Zotova, I. V.; Sergeev, A. S.; Zheleznov, I. V.; Samsonov, S. V.; Mishakin, S. V.

2015-01-01

A time-domain self consistent theory of a gyrotron traveling wave tube with a helically corrugated operating waveguide has been developed. Based on this model, the process of short pulse amplification was studied in regimes of grazing and intersection of the dispersion curves of the electromagnetic wave and the electron beam. In the first case, the possibility of amplification without pulse form distortion was demonstrated for the pulse spectrum width of the order of the gain bandwidth. In the second case, when the electrons' axial velocity was smaller than the wave's group velocity, it was shown that the slippage of the incident signal with respect to the electron beam provides feeding of the signal by “fresh” electrons without initial modulation. As a result, the amplitude of the output pulse can exceed the amplitude of its saturated value for the case of the grazing regime, and, for optimal parameters, the peak output power can be even larger than the kinetic power of the electron beam

Mechanical response of agar gel irradiated with Nd:YAG nanosecond laser pulses

Science.gov (United States)

Pérez-Gutiérrez, Francisco G.; Evans, Rodger; Camacho-López, Santiago; Aguilar, Guillermo

2010-02-01

Nanosecond long laser pulses are used in medical applications where precise tissue ablation with minimal thermal and mechanical collateral damage is required. When a laser pulse is incident on a material, optical energy will be absorbed by a combination of linear and nonlinear absorption according to both: laser light intensity and material properties. In the case of water or gels, the first results in heat generation and thermoelastic expansion; while the second results in an expanding plasma formation that launches a shock wave and a cavitation/boiling bubble. Plasma formation due to nonlinear absorption of nanosecond laser pulses is originated by a combination of multiphoton ionization and thermionic emission of free electrons, which is enhanced when the material has high linear absorption coefficient. In this work, we present measurements of pressure transients originated when 6 ns laser pulses are incident on agar gels with varying linear absorption coefficient, mechanical properties and irradiation geometry using laser radiant exposures above threshold for bubble formation. The underlying hypothesis is that pressure transients are composed of the superposition of both: shock wave originated by hot expanding plasma resulting from nonlinear absorption of optical energy and, thermoelastic expansion originated by heat generation due to linear absorption of optical energy. The objective of this work is to evaluate the relative contribution of each absorption mechanism to mechanical effects in agar gel. Real time pressure transients are recorded with PVDF piezoelectric sensors and time-resilved imaging from 50 μm to 10 mm away from focal point.

Pulsed Tm:YAG laser ablation of knee joint tissues

Science.gov (United States)

Shi, Wei-Qiang; Vari, Sandor G.; Duffy, J. T.; Miller, J. M.; Weiss, Andrew B.; Fishbein, Michael C.; Grundfest, Warren S.

1992-06-01

We investigated the effect of a free-running 2.01 micron pulsed Tm:YAG laser on bovine knee joint tissues. Ablation rates of fresh fibrocartilage, hyaline cartilage, and bone were measured in saline as a function of laser fluence (160 - 640 J/cm2) and fiber core size (400 and 600 microns). All tissues could be effectively ablated and the ablation rate increased linearly with the increasing fluence. Use of fibers of different core sizes, while maintaining constant energy fluence, did not result in significant difference in ablation rate. Histology analyses of the ablated tissue samples reveal average Tm:YAG radiation induced thermal damage (denatunalization) zones ranging between 130 and 540 microns, depending on the laser parameters and the tissue type.

Generalization of Bateman-Hillion progressive wave and Bessel-Gauss pulse solutions of the wave equation via a separation of variables

CERN Document Server

Kiselev, A

2003-01-01

Two new families of exact solutions of the wave equation u sub x sub x + u sub y sub y + u sub z sub z - c sup - sup 2 u sub t sub t = 0 generalizing Bessel-Gauss pulses and Bateman-Hillion relatively undistorted progressive waves, respectively are presented. In each of these families new simple solutions describing localized wave propagation are found. The approach is based on a kind of separation of variables. (letter to the editor)

Pulse wave velocity 24-hour monitoring with one-site measurements by oscillometry

Directory of Open Access Journals (Sweden)

Posokhov IN

2013-02-01

Full Text Available Igor N PosokhovHemodynamic Laboratory Ltd, Nizhniy Novgorod, RussiaAbstract: This review describes issues for the estimation of pulse wave velocity (PWV under ambulatory conditions using oscillometric systems. The difference between the principles of measuring the PWV by the standard method and by oscillometry is shown, and information on device validation studies is summarized. It was concluded that currently oscillometry is a method that is very convenient to use in the 24-hour monitoring of the PWV, is relatively accurate, and is reasonably comfortable for the patient. Several indices with the same principles as those in the analysis of blood pressure in ambulatory monitoring of blood pressure, namely the assessment of load, variability, and circadian rhythm, are proposed.Keywords: pulse wave velocity, 24-hour monitoring, oscillometry

Morphological changes in skeletal muscle after irradiation with nano- and microsecond laser pulses

International Nuclear Information System (INIS)

Gratzl, T.

1995-09-01

For therapeutic application of laser light it is necessary to minimize defects in the nonirradiated tissue. These defects depend on the primary mechanism of interaction between tissue and laser light. Three experiments were performed to distinguish between mechanical and thermal effects of nano- and microsecond laser pulses in skeletal muscle of the rat. The light, transmission and scanning electron microscopes were used. Laser pulses were applied to unfixed muscle immediately after dissection. A Nd-YAG laser (wavelength 1064 nm; pulse repetition rate 10s -1 ; beam diameter 9 mm; pulse-energy 340 mJ) was used in the flashlamp-pulsed mode (pulse duration 100 μs) and the Q-switched mode (pulse duration 8 ns). When focused 2 mm below the tissue surface in the μs-experiments (100 μs) 200 laser pulses produced a small crater. The defective region after irradiation can be divided under the light microscope into four zones surrounding the crater. The innermost zone I showed vacuoles in the intensively stained muscle cells. In the next zone II the myofibrils were displaced and torn apart. Zone III is a sharply bordered, intensively stained region. The muscle cells in zone IV are contracted. All these tissue effects were thermally induced. When focused 4 mm below the tissue surface, the μs-pulses produced an expansion of the irradiated region, while leaving the surface intact. Here, only the features of zones II to IV were seen. In the spallation experiments muscle samples were placed on metal foil. The foil itself was dipped into water. A single laser pulse (8 ns) was directed at the underside of the foil. Only the pressure wave passed through the sample and was reflected on the muscle surface in a stretch wave. Tissue damage by mechanical action occurs inside the sample. Muscle fibers are torn apart and myofibrils are displaced. In the ns-experiments the mechanical action of a single ns pulse (8 ns) produced a crater. Only zones I and IV developed. With 50 to 100

Effects of bee venom acupuncture on heart rate variability, pulse wave, and cerebral blood flow for types of Sasang Constitution

Directory of Open Access Journals (Sweden)

Lee Sang-min

2009-03-01

Full Text Available 1. Objectives: To evaluate effects of bee venom acupuncture on cardiovascular system and differences according to each constitution. 2. Methods: Heart rate variability, pulse wave and the velocity of cerebral blood flow were measured before bee venom acupuncture(BVA, right after and after 30 minuets, had been applied to 20 subjects. 3. Results: 1. BVA did not have effects on measurement variables of heart rate variability. 2. BVA had effects on pulse wave, showing total time, radial augmentation index up and height of percussion wave, time to percussion wave, sum of pulse pressure down. 3. BVA did not have effects on the cerebral blood flow velocity when considering not Sasang Constitution 4. Considering Sasang Constitution, BVA demonstrates different responses in time to preincisura wave, mean blood flow velocity, peak systolic velocity and end diastolic velocity. 4.Conclusion: From those results, the following conclusions are obtained. Cause BVA alters pulse wave and makes differences in the cerebral blood flow velocity according to Sasang Constitution. Various methods of BVA treatment are needed considering Sasang Constitution.

Human Heart Pulse Wave Responses Measured Simultaneously at Several Sensor Placements by Two MR-Compatible Fibre Optic Methods

Directory of Open Access Journals (Sweden)

Teemu Myllylä

2012-01-01

Full Text Available This paper presents experimental measurements conducted using two noninvasive fibre optic methods for detecting heart pulse waves in the human body. Both methods can be used in conjunction with magnetic resonance imaging (MRI. For comparison, the paper also performs an MRI-compatible electrocardiogram (ECG measurement. By the simultaneous use of different measurement methods, the propagation of pressure waves generated by each heart pulse can be sensed extensively in different areas of the human body and at different depths, for example, on the chest and forehead and at the fingertip. An accurate determination of a pulse wave allows calculating the pulse transit time (PTT of a particular heart pulse in different parts of the human body. This result can then be used to estimate the pulse wave velocity of blood flow in different places. Both measurement methods are realized using magnetic resonance-compatible fibres, which makes the methods applicable to the MRI environment. One of the developed sensors is an extraordinary accelerometer sensor, while the other one is a more common sensor based on photoplethysmography. All measurements, involving several test patients, were performed both inside and outside an MRI room. Measurements inside the MRI room were conducted using a 3-Tesla strength closed MRI scanner in the Department of Diagnostic Radiology at the Oulu University Hospital.

Color M-mode and pulsed wave tissue Doppler echocardiography

DEFF Research Database (Denmark)

Møller, J E; Søndergaard, E; Poulsen, S H

2001-01-01

To assess the association between color M-mode flow propagation velocity and the early diastolic mitral annular velocity (E(m)) obtained with tissue Doppler echocardiography and to assess the prognostic implications of the indexes, echocardiography was performed on days 1 and 5, and 1 and 3 month...

Pulsed photothermal radiometry in investigation of tissue destruction caused by CO2 laser action

Science.gov (United States)

Chebotareva, Galina P.; Zubov, Boris V.; Nikitin, Alexander P.; Rakcheev, Anatolii P.; Alexeeva, Larisa R.

1994-12-01

Pulsed photothermal radiometry (PPTR) of tissue based on the analysis of thermal radiation kinetics measured from tissue at laser heating is an effective method of laser-tissue interaction investigation. The processes of destruction under laser radiation action (coagulation, fusion and welding), which are characterized by definite dynamics of temperature in the region of laser heating, have been studied. The amplitude and kinetics of the thermal signal registered by PPTR technique depend on space and temporal temperature changes in the zone of heating, which is conditioned by the regime of laser action and internal processes in tissue. In the present study the investigation of thermal tissue destruction under action of high-power pulsed CO2 and YAG:Er-laser radiation has been carried out using PPTR. Soft and hard tissues have been examined. The nonlinear dependencies of thermal emission kinetics, the thermal signal amplitude, and the integral absorption on laser energy density are presented and discussed. We represent PPTR as a technique which can be used for the definition of the destruction threshold and for the regulation of laser action on tissue. PPTR method has been applied in clinics with the aim of more accurate definition of CO2 pulsed medical laser radiation dose for treatment of patients with different dermatological diseases.

Spiral waves characterization: Implications for an automated cardiodynamic tissue characterization.

Science.gov (United States)

Alagoz, Celal; Cohen, Andrew R; Frisch, Daniel R; Tunç, Birkan; Phatharodom, Saran; Guez, Allon

2018-07-01

Spiral waves are phenomena observed in cardiac tissue especially during fibrillatory activities. Spiral waves are revealed through in-vivo and in-vitro studies using high density mapping that requires special experimental setup. Also, in-silico spiral wave analysis and classification is performed using membrane potentials from entire tissue. In this study, we report a characterization approach that identifies spiral wave behaviors using intracardiac electrogram (EGM) readings obtained with commonly used multipolar diagnostic catheters that perform localized but high-resolution readings. Specifically, the algorithm is designed to distinguish between stationary, meandering, and break-up rotors. The clustering and classification algorithms are tested on simulated data produced using a phenomenological 2D model of cardiac propagation. For EGM measurements, unipolar-bipolar EGM readings from various locations on tissue using two catheter types are modeled. The distance measure between spiral behaviors are assessed using normalized compression distance (NCD), an information theoretical distance. NCD is a universal metric in the sense it is solely based on compressibility of dataset and not requiring feature extraction. We also introduce normalized FFT distance (NFFTD) where compressibility is replaced with a FFT parameter. Overall, outstanding clustering performance was achieved across varying EGM reading configurations. We found that effectiveness in distinguishing was superior in case of NCD than NFFTD. We demonstrated that distinct spiral activity identification on a behaviorally heterogeneous tissue is also possible. This report demonstrates a theoretical validation of clustering and classification approaches that provide an automated mapping from EGM signals to assessment of spiral wave behaviors and hence offers a potential mapping and analysis framework for cardiac tissue wavefront propagation patterns. Copyright © 2018 Elsevier B.V. All rights reserved.

Research of the elastic waves generated by a pulse laser. Excitation mechanism of elastic waves and application to nondestructive testing; Pulse laser de reikishita danseiha ni kansuru kenkyu. Danseiha reiki no mechanism to hihakai kensa eno oyo

Energy Technology Data Exchange (ETDEWEB)

Cho, H.; Takemoto, M. [Aoyama Gakuin University, Tokyo (Japan). College of Science and Engineering

1994-07-20

A bulk wave is generated when a pulse laser is irradiated to the material, and the characteristics of a Young`s modulus and Poisson`s ratio can be nondestructively estimated from the bulk wave. The generation mechanism of laser ultrasonic waves must be first clarified for such application. In this paper, fundamental research was conducted to study the generation mechanism of the elastic waves excited by a Q-switched Nd-YAG laser, and the generation method and characteristics of Rayleigh waves. The following result was obtained. A bulk wave is generated by the disk-like adiabatic expansion near the surface if the laser power is small when a spot-shape pulse laser was irradiated. A bulk wave is generated by the thin disk-like adiabatic expansion beneath the surface due to the thermal diffusion in the depth direction of a base material when the laser power becomes large. Moreover, a bulk wave is generated by the impact force due to abrasion and plasma when the power becomes still larger. The information on the bulk wave characteristics and Rayleigh wave was also obtained. 25 refs., 15 figs., 1 tab.

Bit rate and pulse width dependence of four-wave mixing of short optical pulses in semiconductor optical amplifiers

DEFF Research Database (Denmark)

Diez, S.; Mecozzi, A.; Mørk, Jesper

1999-01-01

We investigate the saturation properties of four-wave mixing of short optical pulses in a semiconductor optical amplifier. By varying the gain of the optical amplifier, we find a strong dependence of both conversion efficiency and signal-to-background ratio on pulse width and bit rate....... In particular, the signal-to-background ratio can be optimized for a specific amplifier gain. This behavior, which is coherently described in experiment and theory, is attributed to the dynamics of the amplified spontaneous emission, which is the main source of noise in a semiconductor optical amplifier....

[A quick algorithm of dynamic spectrum photoelectric pulse wave detection based on LabVIEW].

Science.gov (United States)

Lin, Ling; Li, Na; Li, Gang

2010-02-01

Dynamic spectrum (DS) detection is attractive among the numerous noninvasive blood component detection methods because of the elimination of the main interference of the individual discrepancy and measure conditions. DS is a kind of spectrum extracted from the photoelectric pulse wave and closely relative to the artery blood. It can be used in a noninvasive blood component concentration examination. The key issues in DS detection are high detection precision and high operation speed. The precision of measure can be advanced by making use of over-sampling and lock-in amplifying on the pick-up of photoelectric pulse wave in DS detection. In the present paper, the theory expression formula of the over-sampling and lock-in amplifying method was deduced firstly. Then in order to overcome the problems of great data and excessive operation brought on by this technology, a quick algorithm based on LabVIEW and a method of using external C code applied in the pick-up of photoelectric pulse wave were presented. Experimental verification was conducted in the environment of LabVIEW. The results show that by the method pres ented, the speed of operation was promoted rapidly and the data memory was reduced largely.

Pulse wave analysis in a 180-degree curved artery model: Implications under physiological and non-physiological inflows

Science.gov (United States)

Bulusu, Kartik V.; Plesniak, Michael W.

2013-11-01

Systolic and diastolic blood pressures, pulse pressures, and left ventricular hypertrophy contribute to cardiovascular risks. Increase of arterial stiffness due to aging and hypertension is an important factor in cardiovascular, chronic kidney and end-stage-renal-diseases. Pulse wave analysis (PWA) based on arterial pressure wave characteristics, is well established in clinical practice for evaluation of arterial distensibility and hypertension. The objective of our exploratory study in a rigid 180-degree curved artery model was to evaluate arterial pressure waveforms. Bend upstream conditions were measured using a two-component, two-dimensional, particle image velocimeter (2C-2D PIV). An ultrasonic transit-time flow meter and a catheter with a MEMS-based solid state pressure sensor, capable of measuring up to 20 harmonics of the observed pressure waveform, monitored flow conditions downstream of the bend. Our novel continuous wavelet transform algorithm (PIVlet 1.2), in addition to detecting coherent secondary flow structures is used to evaluate arterial pulse wave characteristics subjected to physiological and non-physiological inflows. Results of this study will elucidate the utility of wavelet transforms in arterial function evaluation and pulse wave speed. Supported by NSF Grant No. CBET- 0828903 and GW Center for Biomimetics and Bioinspired Engineering.

Measurements of Electric Field in a Nanosecond Pulse Discharge by 4-WAVE Mixing

Science.gov (United States)

Baratte, Edmond; Adamovich, Igor V.; Simeni Simeni, Marien; Frederickson, Kraig

2017-06-01

Picosecond four-wave mixing is used to measure temporally and Picosecond four-wave mixing is used to measure temporally and spatially resolved electric field in a nanosecond pulse dielectric discharge sustained in room air and in an atmospheric pressure hydrogen diffusion flame. Measurements of the electric field, and more precisely the reduced electric field (E/N) in the plasma is critical for determination rate coefficients of electron impact processes in the plasma, as well as for quantifying energy partition in the electric discharge among different molecular energy modes. The four-wave mixing measurements are performed using a collinear phase matching geometry, with nitrogen used as the probe species, at temporal resolution of about 2 ns . Absolute calibration is performed by measurement of a known electrostatic electric field. In the present experiments, the discharge is sustained between two stainless steel plate electrodes, each placed in a quartz sleeve, which greatly improves plasma uniformity. Our previous measurements of electric field in a nanosecond pulse dielectric barrier discharge by picosecond 4-wave mixing have been done in air at room temperature, in a discharge sustained between a razor edge high-voltage electrode and a plane grounded electrode (a quartz plate or a layer of distilled water). Electric field measurements in a flame, which is a high-temperature environment, are more challenging because the four-wave mixing signal is proportional to the to square root of the difference betwen the populations of N2 ground vibrational level (v=0) and first excited vibrational level (v=1). At high temperatures, the total number density is reduced, thus reducing absolute vibrational level populations of N2. Also, the signal is reduced further due to a wider distribution of N2 molecules over multiple rotational levels at higher temperatures, while the present four-wave mixing diagnostics is using spectrally narrow output of a ps laser and a high

Continuous and pulsed laser high power beam combiner for additive manufacturing applications

Science.gov (United States)

Bassignana, Marta; Califano, Alessio; Pescarmona, Francesco; Braglia, Andrea; Perrone, Guido

2018-02-01

Laser-based additive manufacturing (AM) from metal powders is emerging as the new industrial revolution, although current fabrication approaches still require long mechanical post-processing to improve the final surface quality and meet the design tolerances. To overcome this limitation, the next generation machines are expected to complement laser AM with laser ablation (LA) to implement surface finishing and micro texturing already during the device growth process. With this aim, a new beam combiner to allow the real-time interchange of additive and subtractive processes using the same scanner head has been designed. Extensive tests have been carried out using a 6 kW continuous-wave laser similar to that used for the metal powder fusion and a nanosecond 100W pulsed source similar to that used for laser ablation.

Tracking nuclear wave-packet dynamics in molecular oxygen ions with few-cycle infrared laser pulses

International Nuclear Information System (INIS)

De, S.; Bocharova, I. A.; Magrakvelidze, M.; Ray, D.; Cao, W.; Thumm, U.; Cocke, C. L.; Bergues, B.; Kling, M. F.; Litvinyuk, I. V.

2010-01-01

We have tracked nuclear wave-packet dynamics in doubly charged states of molecular oxygen using few-cycle infrared laser pulses. Bound and dissociating wave packets were launched and subsequently probed via a pair of 8-fs pulses of 790 nm radiation. Ionic fragments from the dissociating molecules were monitored by velocity-map imaging. Pronounced oscillations in the delay-dependent kinetic energy release spectra were observed. The occurrence of vibrational revivals permits us to identify the potential curves of the O 2 dication which are most relevant to the molecular dynamics. These studies show the accessibility to the dynamics of such higher-charged molecules.

Radiobiological influence of megavoltage electron pulses of ultra-high pulse dose rate on normal tissue cells.

Science.gov (United States)

Laschinsky, Lydia; Karsch, Leonhard; Leßmann, Elisabeth; Oppelt, Melanie; Pawelke, Jörg; Richter, Christian; Schürer, Michael; Beyreuther, Elke

2016-08-01

Regarding the long-term goal to develop and establish laser-based particle accelerators for a future radiotherapeutic treatment of cancer, the radiobiological consequences of the characteristic short intense particle pulses with ultra-high peak dose rate, but low repetition rate of laser-driven beams have to be investigated. This work presents in vitro experiments performed at the radiation source ELBE (Electron Linac for beams with high Brilliance and low Emittance). This accelerator delivered 20-MeV electron pulses with ultra-high pulse dose rate of 10(10) Gy/min either at the low pulse frequency analogue to previous cell experiments with laser-driven electrons or at high frequency for minimizing the prolonged dose delivery and to perform comparison irradiation with a quasi-continuous electron beam analogue to a clinically used linear accelerator. The influence of the different electron beam pulse structures on the radiobiological response of the normal tissue cell line 184A1 and two primary fibroblasts was investigated regarding clonogenic survival and the number of DNA double-strand breaks that remain 24 h after irradiation. Thereby, no considerable differences in radiation response were revealed both for biological endpoints and for all probed cell cultures. These results provide evidence that the radiobiological effectiveness of the pulsed electron beams is not affected by the ultra-high pulse dose rates alone.

Radiobiological influence of megavoltage electron pulses of ultra-high pulse dose rate on normal tissue cells

International Nuclear Information System (INIS)

Laschinsky, Lydia; Karsch, Leonhard; Schuerer, Michael; Lessmann, Elisabeth; Beyreuther, Elke; Oppelt, Melanie; Pawelke, Joerg; Richter, Christian

2016-01-01

Regarding the long-term goal to develop and establish laser-based particle accelerators for a future radiotherapeutic treatment of cancer, the radiobiological consequences of the characteristic short intense particle pulses with ultra-high peak dose rate, but low repetition rate of laser-driven beams have to be investigated. This work presents in vitro experiments performed at the radiation source ELBE (Electron Linac for beams with high Brilliance and low Emittance). This accelerator delivered 20-MeV electron pulses with ultra-high pulse dose rate of 10"1"0 Gy/min either at the low pulse frequency analogue to previous cell experiments with laser-driven electrons or at high frequency for minimizing the prolonged dose delivery and to perform comparison irradiation with a quasi-continuous electron beam analogue to a clinically used linear accelerator. The influence of the different electron beam pulse structures on the radiobiological response of the normal tissue cell line 184A1 and two primary fibroblasts was investigated regarding clonogenic survival and the number of DNA double-strand breaks that remain 24 h after irradiation. Thereby, no considerable differences in radiation response were revealed both for biological endpoints and for all probed cell cultures. These results provide evidence that the radiobiological effectiveness of the pulsed electron beams is not affected by the ultra-high pulse dose rates alone. (orig.)

Quantifying the Benefits of Combining Offshore Wind and Wave Energy

Science.gov (United States)

Stoutenburg, E.; Jacobson, M. Z.

2009-12-01

For many locations the offshore wind resource and the wave energy resource are collocated, which suggests a natural synergy if both technologies are combined into one offshore marine renewable energy plant. Initial meteorological assessments of the western coast of the United States suggest only a weak correlation in power levels of wind and wave energy at any given hour associated with the large ocean basin wave dynamics and storm systems of the North Pacific. This finding indicates that combining the two power sources could reduce the variability in electric power output from a combined wind and wave offshore plant. A combined plant is modeled with offshore wind turbines and Pelamis wave energy converters with wind and wave data from meteorological buoys operated by the US National Buoy Data Center off the coast of California, Oregon, and Washington. This study will present results of quantifying the benefits of combining wind and wave energy for the electrical power system to facilitate increased renewable energy penetration to support reductions in greenhouse gas emissions, and air and water pollution associated with conventional fossil fuel power plants.

Effects of Obesity and Hypertension on Pulse Wave Velocity in Children.

Science.gov (United States)

Kulsum-Mecci, Nazia; Goss, Charles; Kozel, Beth A; Garbutt, Jane M; Schechtman, Kenneth B; Dharnidharka, Vikas R

2017-03-01

Pulse wave velocity (PWV) is a biomarker of arterial stiffness. Findings from prior studies are conflicting regarding the impact of obesity on PWV in children. The authors measured carotid-femoral PWV in 159 children aged 4 to 18 years, of whom 95 were healthy, 25 were obese, 15 had hypertension (HTN), and 24 were both obese and hypertensive. Mean PWV increased with age but did not differ by race or sex. In adjusted analyses in children 10 years and older (n=102), PWV was significantly higher in children with hypertension (PWV±standard deviation, 4.9±0.7 m/s), obesity (5.0±0.9 m/s), and combined obesity-hypertension (5.2±0.6 m/s) vs healthy children (4.3±0.7 m/s) (each group, Pobesity and HTN both significantly and independently increased PWV, while African American children did not have a higher PWV than Caucasian children. ©2016 Wiley Periodicals, Inc.

Spatial-temporal ultrasound imaging of residual cavitation bubbles around a fluid-tissue interface in histotripsy.

Science.gov (United States)

Hu, Hong; Xu, Shanshan; Yuan, Yuan; Liu, Runna; Wang, Supin; Wan, Mingxi

2015-05-01

Cavitation is considered as the primary mechanism of soft tissue fragmentation (histotripsy) by pulsed high-intensity focused ultrasound. The residual cavitation bubbles have a dual influence on the histotripsy pulses: these serve as nuclei for easy generation of new cavitation, and act as strong scatterers causing energy "shadowing." To monitor the residual cavitation bubbles in histotripsy, an ultrafast active cavitation imaging method with relatively high signal-to-noise ratio and good spatial-temporal resolution was proposed in this paper, which combined plane wave transmission, minimum variance beamforming, and coherence factor weighting. The spatial-temporal evolutions of residual cavitation bubbles around a fluid-tissue interface in histotripsy under pulse duration (PD) of 10-40 μs and pulse repetition frequency (PRF) of 0.67-2 kHz were monitored by this method. The integrated bubble area curves inside the tissue interface were acquired from the bubble image sequence, and the formation process of histotripsy damage was estimated. It was observed that the histotripsy efficiency decreased with both longer PDs and higher PRFs. A direct relationship with a coefficient of 1.0365 between histotripsy lesion area and inner residual bubble area was found. These results can assist in monitoring and optimization of the histotripsy treatment further.

High-efficiency generation of pulsed Lyman-α radiation by resonant laser wave mixing in low pressure Kr-Ar mixture.

Science.gov (United States)

Saito, Norihito; Oishi, Yu; Miyazaki, Koji; Okamura, Kotaro; Nakamura, Jumpei; Louchev, Oleg A; Iwasaki, Masahiko; Wada, Satoshi

2016-04-04

We report an experimental generation of ns pulsed 121.568 nm Lyman-α radiation by the resonant nonlinear four-wave mixing of 212.556 nm and 845.015 nm radiation pulses providing a high conversion efficiency 1.7x10-3 with the output pulse energy 3.6 μJ achieved using a low pressure Kr-Ar mixture. Theoretical analysis shows that this efficiency is achieved due to the advantage of using (i) the high input laser intensities in combination with (ii) the low gas pressure allowing us to avoid the onset of full-scale discharge in the laser focus. In particular, under our experimental conditions the main mechanism of photoionization caused by the resonant 2-photon 212.556 nm radiation excitation of Kr atoms followed by the 1-photon ionization leads to ≈17% loss of Kr atoms and efficiency loss only by the end of the pulse. The energy of free electrons, generated by 212.556 nm radiation via (2 + 1)-photon ionization and accelerated mainly by 845.015 nm radiation, remains during the pulse below the level sufficient for the onset of full-scale discharge by the electron avalanche. Our analysis also suggests that ≈30-fold increase of 845.015 nm pulse energy can allow one to scale up the L-α radiation pulse energy towards the level of ≈100 μJ.

SiOx Ink-Repellent Layer Deposited by Radio Frequency (RF) Plasmas in Continuous Wave and Pulse Mode

International Nuclear Information System (INIS)

Chen Qiang; Fu Yabo; Pang Hua; Zhang Yuefei; Zhang Guangqiu

2007-01-01

Low surface energy layers, proposed application for non-water printing in computer to plate (CTP) technology, are deposited in both continuous wave and pulse radio frequency (13.56 MHz) plasma with hexamethyldisiloxane (HMDSO) as precursor. It is found that the plasma mode dominates the polymer growth rate and the surface composition. Derived from the spectra of X-ray photoelectron spectroscopy (XPS) and combined with printable test it is concluded that concentration of Si in coatings plays an important role for the ink printability and the ink does not adhere on the surface with high silicon concentration

The energy and temporal characteristics of orthogonal polarized waves generated by a transversely-excited pulsed CO/sub 2/ laser

Energy Technology Data Exchange (ETDEWEB)

Bertel, I.M.; Churakov, V.V.; Petukhov, V.O.; Prokopov, A.P.; Trushin, S.A.; Voitovich, A.P.

1980-01-01

The competition of orthogonally-polarized waves with various differences in the wave Q-factors and active medium pressures is studied. The possibility of controlling the parameters of a pulsed CO/sub 2/ laser by changing the value of the amplitude anisotropy of the cavity is demonstrated. The duration of the emission pulse for one of two orthogonal polarizations was reduced by virtually 50%.

Optimization of arterial age prediction models based in pulse wave

Energy Technology Data Exchange (ETDEWEB)

Scandurra, A G [Bioengineering Laboratory, Electronic Department, Mar del Plata University (Argentina); Meschino, G J [Bioengineering Laboratory, Electronic Department, Mar del Plata University (Argentina); Passoni, L I [Bioengineering Laboratory, Electronic Department, Mar del Plata University (Argentina); Dai Pra, A L [Engineering Aplied Artificial Intelligence Group, Mathematics Department, Mar del Plata University (Argentina); Introzzi, A R [Bioengineering Laboratory, Electronic Department, Mar del Plata University (Argentina); Clara, F M [Bioengineering Laboratory, Electronic Department, Mar del Plata University (Argentina)

2007-11-15

We propose the detection of early arterial ageing through a prediction model of arterial age based in the coherence assumption between the pulse wave morphology and the patient's chronological age. Whereas we evaluate several methods, a Sugeno fuzzy inference system is selected. Models optimization is approached using hybrid methods: parameter adaptation with Artificial Neural Networks and Genetic Algorithms. Features selection was performed according with their projection on main factors of the Principal Components Analysis. The model performance was tested using the bootstrap error type .632E. The model presented an error smaller than 8.5%. This result encourages including this process as a diagnosis module into the device for pulse analysis that has been developed by the Bioengineering Laboratory staff.

Optimization of arterial age prediction models based in pulse wave

International Nuclear Information System (INIS)

Scandurra, A G; Meschino, G J; Passoni, L I; Dai Pra, A L; Introzzi, A R; Clara, F M

2007-01-01

We propose the detection of early arterial ageing through a prediction model of arterial age based in the coherence assumption between the pulse wave morphology and the patient's chronological age. Whereas we evaluate several methods, a Sugeno fuzzy inference system is selected. Models optimization is approached using hybrid methods: parameter adaptation with Artificial Neural Networks and Genetic Algorithms. Features selection was performed according with their projection on main factors of the Principal Components Analysis. The model performance was tested using the bootstrap error type .632E. The model presented an error smaller than 8.5%. This result encourages including this process as a diagnosis module into the device for pulse analysis that has been developed by the Bioengineering Laboratory staff

Wavelet brain angiography suggests arteriovenous pulse wave phase locking.

Directory of Open Access Journals (Sweden)

William E Butler

Full Text Available When a stroke volume of arterial blood arrives to the brain, the total blood volume in the bony cranium must remain constant as the proportions of arterial and venous blood vary, and by the end of the cardiac cycle an equivalent volume of venous blood must have been ejected. I hypothesize the brain to support this process by an extraluminally mediated exchange of information between its arterial and venous circulations. To test this I introduce wavelet angiography methods to resolve single moving vascular pulse waves (PWs in the brain while simultaneously measuring brain pulse motion. The wavelet methods require angiographic data acquired at significantly faster rate than cardiac frequency. I obtained these data in humans from brain surface optical angiograms at craniotomy and in piglets from ultrasound angiograms via cranial window. I exploit angiographic time of flight to resolve arterial from venous circulation. Initial wavelet reconstruction proved unsatisfactory because of angiographic motion alias from brain pulse motion. Testing with numerically simulated cerebral angiograms enabled the development of a vascular PW cine imaging method based on cross-correlated wavelets of mixed high frequency and high temporal resolution respectively to attenuate frequency and motion alias. Applied to the human and piglet data, the method resolves individual arterial and venous PWs and finds them to be phase locked each with separate phase relations to brain pulse motion. This is consistent with arterial and venous PW coordination mediated by pulse motion and points to a testable hypothesis of a function of cerebrospinal fluid in the ventricles of the brain.

Energy of a shock wave generated in different metals under irradiation by a high-power laser pulse

International Nuclear Information System (INIS)

Gus'kov, S. Yu.; Kasperczuk, A.; Pisarczyk, T.; Borodziuk, S.; Ullschmied, J.; Krousky, E.; Masek, K.; Pfeifer, M.; Skala, J.; Pisarczyk, P.

2007-01-01

The energies of a shock wave generated in different metals under irradiation by a high-power laser beam were determined experimentally. The experiments were performed with the use of targets prepared from a number of metals, such as aluminum, copper, silver and lead (which belong to different periods of the periodic table) under irradiation by pulses of the first and third harmonics of the PALS iodine laser at a radiation intensity of approximately 10 14 W/cm 2 . It was found that, for heavy metals, like for light solid materials, the fraction of laser radiation energy converted into the energy of a shock wave under irradiation by a laser pulse of the third harmonic considerably (by a factor of 2-3) exceeds the fraction of laser radiation energy converted under irradiation by a laser pulse of the first harmonic. The influence of radiation processes on the efficiency of conversion of the laser energy into the energy of the shock wave was analyzed

Electrical Tree Initiation and Growth in Silicone Rubber under Combined DC-Pulse Voltage

Directory of Open Access Journals (Sweden)

Tao Han

2018-03-01

Full Text Available Electrical tree is a serious threat to silicone rubber (SIR insulation and can even cause breakdown. Electrical trees under alternating current (AC and direct current (DC voltage have been widely researched. While there are pulses in high-voltage direct current (HVDC cables under operating conditions caused by lightning and operating overvoltage in the power system, little research has been reported about trees under combined DC-pulse voltage. Their inception and growth mechanism is still not clear. In this paper, electrical trees are studied under several types of combined DC-pulse voltage. The initiation and growth process was recorded by a digital microscope system. The experimental results indicate that the inception pulse voltage is different under each voltage type and is influenced by the combined DC. The initial tree has two structures, determined by the pulse polarity. With increased DC prestressing time, tree inception pulse voltage with the same polarity is clearly decreased. Moreover, a special initial bubble tree was observed after the prestressing DC.

Supersonic Ionization Wave Driven by Radiation Transport in a Short-Pulse Laser-Produced Plasma

International Nuclear Information System (INIS)

Ditmire, T.; Gumbrell, E.T.; Smith, R.A.; Mountford, L.; Hutchinson, M.H.

1996-01-01

Through the use of an ultrashort (2ps) optical probe, we have time resolved the propagation of an ionization wave into solid fused silica. This ionization wave results when a plasma is created by the intense irradiation of a solid target with a 2ps laser pulse. We find that the velocity of the ionization wave is consistent with radiation driven thermal transport, exceeding the velocity expected from simple electron thermal conduction by nearly an order of magnitude. copyright 1996 The American Physical Society

Scroll-wave dynamics in human cardiac tissue: lessons from a mathematical model with inhomogeneities and fiber architecture.

Directory of Open Access Journals (Sweden)

Rupamanjari Majumder

2011-04-01

Full Text Available Cardiac arrhythmias, such as ventricular tachycardia (VT and ventricular fibrillation (VF, are among the leading causes of death in the industrialized world. These are associated with the formation of spiral and scroll waves of electrical activation in cardiac tissue; single spiral and scroll waves are believed to be associated with VT whereas their turbulent analogs are associated with VF. Thus, the study of these waves is an important biophysical problem. We present a systematic study of the combined effects of muscle-fiber rotation and inhomogeneities on scroll-wave dynamics in the TNNP (ten Tusscher Noble Noble Panfilov model for human cardiac tissue. In particular, we use the three-dimensional TNNP model with fiber rotation and consider both conduction and ionic inhomogeneities. We find that, in addition to displaying a sensitive dependence on the positions, sizes, and types of inhomogeneities, scroll-wave dynamics also depends delicately upon the degree of fiber rotation. We find that the tendency of scroll waves to anchor to cylindrical conduction inhomogeneities increases with the radius of the inhomogeneity. Furthermore, the filament of the scroll wave can exhibit drift or meandering, transmural bending, twisting, and break-up. If the scroll-wave filament exhibits weak meandering, then there is a fine balance between the anchoring of this wave at the inhomogeneity and a disruption of wave-pinning by fiber rotation. If this filament displays strong meandering, then again the anchoring is suppressed by fiber rotation; also, the scroll wave can be eliminated from most of the layers only to be regenerated by a seed wave. Ionic inhomogeneities can also lead to an anchoring of the scroll wave; scroll waves can now enter the region inside an ionic inhomogeneity and can display a coexistence of spatiotemporal chaos and quasi-periodic behavior in different parts of the simulation domain. We discuss the experimental implications of our study.

Evaluation of arterial stiffness by finger-toe pulse wave velocity: optimization of signal processing and clinical validation.

Science.gov (United States)

Obeid, Hasan; Khettab, Hakim; Marais, Louise; Hallab, Magid; Laurent, Stéphane; Boutouyrie, Pierre

2017-08-01

Carotid-femoral pulse wave velocity (PWV) (cf-PWV) is the gold standard for measuring aortic stiffness. Finger-toe PWV (ft-PWV) is a simpler noninvasive method for measuring arterial stiffness. Although the validity of the method has been previously assessed, its accuracy can be improved. ft-PWV is determined on the basis of a patented height chart for the distance and the pulse transit time (PTT) between the finger and the toe pulpar arteries signals (ft-PTT). The objective of the first study, performed in 66 patients, was to compare different algorithms (intersecting tangents, maximum of the second derivative, 10% threshold and cross-correlation) for determining the foot of the arterial pulse wave, thus the ft-PTT. The objective of the second study, performed in 101 patients, was to investigate different signal processing chains to improve the concordance of ft-PWV with the gold-standard cf-PWV. Finger-toe PWV (ft-PWV) was calculated using the four algorithms. The best correlations relating ft-PWV and cf-PWV, and relating ft-PTT and carotid-femoral PTT were obtained with the maximum of the second derivative algorithm [PWV: r = 0.56, P < 0.0001, root mean square error (RMSE) = 0.9 m/s; PTT: r = 0.61, P < 0.001, RMSE = 12 ms]. The three other algorithms showed lower correlations. The correlation between ft-PTT and carotid-femoral PTT further improved (r = 0.81, P < 0.0001, RMSE = 5.4 ms) when the maximum of the second derivative algorithm was combined with an optimized signal processing chain. Selecting the maximum of the second derivative algorithm for detecting the foot of the pressure waveform, and combining it with an optimized signal processing chain, improved the accuracy of ft-PWV measurement in the current population sample. Thus, it makes ft-PWV very promising for the simple noninvasive determination of aortic stiffness in clinical practice.

Laser Generated Leaky Acoustic Waves for Needle Visualization.

Science.gov (United States)

Wu, Kai-Wen; Wang, Yi-An; Li, Pai-Chi

2018-04-01

Ultrasound (US)-guided needle operation is usually used to visualize both tissue and needle position such as tissue biopsy and localized drug delivery. However, the transducer-needle orientation is limited due to reflection of the acoustic waves. We proposed a leaky acoustic wave method to visualize the needle position and orientation. Laser pulses are emitted on top of the needle to generate acoustic waves; then, these acoustic waves propagate along the needle surface. Leaky wave signals are detected by the US array transducer. The needle position can be calculated by phase velocities of two different wave modes and their corresponding emission angles. In our experiments, a series of needles was inserted into a tissue mimicking phantom and porcine tissue to evaluate the accuracy of the proposed method. The results show that the detection depth is up to 51 mm and the insertion angle is up to 40° with needles of different diameters. It is demonstrated that the proposed approach outperforms the conventional B-mode US-guided needle operation in terms of the detection range while achieving similar accuracy. The proposed method reveals the potentials for further clinical applications.

Picosecond pulses from wavelength-swept continuous-wave Fourier domain mode-locked lasers.

Science.gov (United States)

Eigenwillig, Christoph M; Wieser, Wolfgang; Todor, Sebastian; Biedermann, Benjamin R; Klein, Thomas; Jirauschek, Christian; Huber, Robert

2013-01-01

Ultrafast lasers have a crucial function in many fields of science; however, up to now, high-energy pulses directly from compact, efficient and low-power semiconductor lasers are not available. Therefore, we introduce a new approach based on temporal compression of the continuous-wave, wavelength-swept output of Fourier domain mode-locked lasers, where a narrowband optical filter is tuned synchronously to the round-trip time of light in a kilometre-long laser cavity. So far, these rapidly swept lasers enabled orders-of-magnitude speed increase in optical coherence tomography. Here we report on the generation of ~60-70 ps pulses at 390 kHz repetition rate. As energy is stored optically in the long-fibre delay line and not as population inversion in the laser-gain medium, high-energy pulses can now be generated directly from a low-power, compact semiconductor-based oscillator. Our theory predicts subpicosecond pulses with this new technique in the future.

Radial shock wave treatment alone is less efficient than radial shock wave treatment combined with tissue-specific plantar fascia-stretching in patients with chronic plantar heel pain.

Science.gov (United States)

Rompe, Jan D; Furia, John; Cacchio, Angelo; Schmitz, Christoph; Maffulli, Nicola

2015-12-01

Whether shock wave therapy or shock wave therapy combined with plantar fascia-specific stretching is more efficient in treating chronic plantar heel pain remains unclear. The aim of the study was to test the null hypothesis of no difference of these two forms of management for patients who had unilateral plantar fasciopathy for a minimum duration of twelve months and which had failed at least three other forms of treatment. One hundred and fifty-two patients with chronic plantar fasciopathy were assigned to receive repetitive low-energy radial shock-wave therapy without local anesthesia, administered weekly for three weeks (Group 1, n = 73) or to receive the identical shock wave treatment and to perform an eight-week plantar fascia-specific stretching program (Group 2, n = 79). All patients completed the nine-item pain subscale of the validated Foot Function Index and a subject-relevant outcome questionnaire. Patients were evaluated at baseline, and at two, four, and twenty-four months after baseline. The primary outcome measures were a mean change in the Foot Function Index sum score at two months after baseline, a mean change in item 2 (pain during the first steps of walking in the morning) on this Index, and satisfaction with treatment. No difference in mean age, sex, weight or duration of symptoms was found between the groups at baseline. At two months after baseline, the Foot Function Index sum score showed significantly greater changes for the patients managed with shock-wave therapy plus plantar fascia-specific stretching than those managed with shock-wave therapy alone (p plantar fascia in combination with repetitive low-energy radial shock-wave therapy is more efficient than repetitive low-energy radial shock-wave therapy alone for the treatment of chronic symptoms of proximal plantar fasciopathy. Copyright © 2015 IJS Publishing Group Limited. Published by Elsevier Ltd. All rights reserved.

Time scale of scour around a pile in combined waves and current

DEFF Research Database (Denmark)

Petersen, Thor Ugelvig; Sumer, B. Mutlu; Fredsøe, Jørgen

The time scale of the scour process around a circular vertical pile is studied in combined waves and current. A series of tests were carried out in a flume with pile diameters 40 mm and 75 mm, in both steady current, waves and combined waves and current. In the combined wave and current flow regime...... the waves and the current were co-directional. All the tests were conducted in the live bed regime. The time scale of scour in combined waves and current is governed by three parameters, namely the current-velocity-to-wave-velocity ratio (Ucw), the Keulegan–Carpenter number (KC) and Shields parameter (Θw...

Physical properties of hydrated tissue determined by surface interferometry of laser-induced thermoelastic deformation

Science.gov (United States)

Dark, Marta L.; Perelman, Lev T.; Itzkan, Irving; Schaffer, Jonathan L.; Feld, Michael S.

2000-02-01

Knee meniscus is a hydrated tissue; it is a fibrocartilage of the knee joint composed primarily of water. We present results of interferometric surface monitoring by which we measure physical properties of human knee meniscal cartilage. The physical response of biological tissue to a short laser pulse is primarily thermomechanical. When the pulse is shorter than characteristic times (thermal diffusion time and acoustic relaxation time) stresses build and propagate as acoustic waves in the tissue. The tissue responds to the laser-induced stress by thermoelastic expansion. Solving the thermoelastic wave equation numerically predicts the correct laser-induced expansion. By comparing theory with experimental data, we can obtain the longitudinal speed of sound, the effective optical penetration depth and the Grüneisen coefficient. This study yields information about the laser-tissue interaction and determines properties of the meniscus samples that could be used as diagnostic parameters.

Frequency modulation and compression of optical pulses in an optical fibre with a travelling refractive-index wave

Energy Technology Data Exchange (ETDEWEB)

Zolotovskii, I O; Lapin, V A; Sementsov, D I [Ulyanovsk State University, Ulyanovsk (Russian Federation)

2016-01-31

We have studied the conditions for spectral broadening, frequency modulation and compression (both temporal and spectral) of Gaussian pulses propagating in a fibre with a travelling refractive-index wave. Analytical expressions have been derived for the dependences of pulse duration, chirp and spectral width on the distance travelled through the fibre, parameters of the fibre and radiation launched into it. Based on the numerical analysis we have studied the behaviour of these characteristics by changing the coefficient of the refractive-index modulation and other parameters of the travelling refractive-index wave. (nonlinear optical phenomena)

Preparing isolated vibrational wave packets with light-induced molecular potentials by chirped laser pulses

Science.gov (United States)

Vatasescu, Mihaela

2012-05-01

We consider a specific wave packet preparation arising from the control of tunneling in the 0g-(6s,6p3/2) double well potential of a Cs2 cold molecule with chirped laser pulses. Such a possibility to manipulate the population dynamics in the 0g-(6s,6p3/2) potential appears in a pump-dump scheme designed to form cold molecules by photoassociation of two cold cesium atoms. The initial population in the 0g-(6s,6p3/2) double well is a wave packet prepared in the outer well at large interatomic distances (94 a0) by a photoassociation step with a first chirped pulse, being a superposition of several vibrational states whose energies surround the energy of a tunneling resonance. Our present work is focused on a second delayed chirped pulse, coupling the 0g-(6s,6p3/2) surface with the a3Σu+(6s,6s) one in the zone of the double well barrier (15 a0) and creating deeply bound cold molecules in the a3Σu+(6s,6s) state. We explore the parameters choice (intensity, duration, chirp rate and sign) for this second pulse, showing that picoseconds pulses with a negative chirp can lead to trapping of population in the inner well in strongly bound vibrational states, out of the resonant tunneling able to transfer it back to the outer well.

Comparison of therapeutic effects between pulsed and continuous wave 810-nm wavelength laser irradiation for traumatic brain injury in mice.

Directory of Open Access Journals (Sweden)

Takahiro Ando

Full Text Available Transcranial low-level laser therapy (LLLT using near-infrared light can efficiently penetrate through the scalp and skull and could allow non-invasive treatment for traumatic brain injury (TBI. In the present study, we compared the therapeutic effect using 810-nm wavelength laser light in continuous and pulsed wave modes in a mouse model of TBI.TBI was induced by a controlled cortical-impact device and 4-hours post-TBI 1-group received a sham treatment and 3-groups received a single exposure to transcranial LLLT, either continuous wave or pulsed at 10-Hz or 100-Hz with a 50% duty cycle. An 810-nm Ga-Al-As diode laser delivered a spot with diameter of 1-cm onto the injured head with a power density of 50-mW/cm(2 for 12-minutes giving a fluence of 36-J/cm(2. Neurological severity score (NSS and body weight were measured up to 4 weeks. Mice were sacrificed at 2, 15 and 28 days post-TBI and the lesion size was histologically analyzed. The quantity of ATP production in the brain tissue was determined immediately after laser irradiation. We examined the role of LLLT on the psychological state of the mice at 1 day and 4 weeks after TBI using tail suspension test and forced swim test.The 810-nm laser pulsed at 10-Hz was the most effective judged by improvement in NSS and body weight although the other laser regimens were also effective. The brain lesion volume of mice treated with 10-Hz pulsed-laser irradiation was significantly lower than control group at 15-days and 4-weeks post-TBI. Moreover, we found an antidepressant effect of LLLT at 4-weeks as shown by forced swim and tail suspension tests.The therapeutic effect of LLLT for TBI with an 810-nm laser was more effective at 10-Hz pulse frequency than at CW and 100-Hz. This finding may provide a new insight into biological mechanisms of LLLT.

The Effects of Hemodynamic Changes on Pulse Wave Velocity in Cardiothoracic Surgical Patients

Directory of Open Access Journals (Sweden)

Yurie Obata

2016-01-01

Full Text Available The effect of blood pressure on pulse wave velocity (PWV is well established. However, PWV variability with acute hemodynamic changes has not been examined in the clinical setting. The aim of the present study is to investigate the effect of hemodynamic changes on PWV in patients who undergo cardiothoracic surgery. Using data from 25 patients, we determined blood pressure (BP, heart rate (HR, and the left ventricular outflow tract (LVOT velocity-time integral. By superimposing the radial arterial waveform on the continuous wave Doppler waveform of the LVOT, obtained by transesophageal echo, we were able to determine pulse transit time and to calculate PWV, stroke volume (SV, cardiac output (CO, and systemic vascular resistance (SVR. Increases in BP, HR, and SVR were associated with higher values for PWV. In contrast increases in SV were associated with decreases in PWV. Changes in CO were not significantly associated with PWV.

Wearable sensor glove based on conducting fabric using electrodermal activity and pulse-wave sensors for e-health application.

Science.gov (United States)

Lee, Youngbum; Lee, Byungwoo; Lee, Myoungho

2010-03-01

Improvement of the quality and efficiency of health in medicine, both at home and the hospital, calls for improved sensors that might be included in a common carrier such as a wearable sensor device to measure various biosignals and provide healthcare services that use e-health technology. Designed to be user-friendly, smart clothes and gloves respond well to the end users for health monitoring. This study describes a wearable sensor glove that is equipped with an electrodermal activity (EDA) sensor, pulse-wave sensor, conducting fabric, and an embedded system. The EDA sensor utilizes the relationship between drowsiness and the EDA signal. The EDA sensors were made using a conducting fabric instead of silver chloride electrodes, as a more practical and practically wearable device. The pulse-wave sensor measurement system, which is widely applied in oriental medicinal practices, is also a strong element in e-health monitoring systems. The EDA and pulse-wave signal acquisition module was constructed by connecting the sensor to the glove via a conductive fabric. The signal acquisition module is then connected to a personal computer that displays the results of the EDA and pulse-wave signal processing analysis and gives accurate feedback to the user. This system is designed for a number of applications for the e-health services, including drowsiness detection and oriental medicine.

Wave Intensity Analysis of Right Ventricular Function during Pulsed Operation of Rotary Left Ventricular Assist Devices.

Science.gov (United States)

Bouwmeester, J Christopher; Park, Jiheum; Valdovinos, John; Bonde, Pramod

2018-05-29

Changing the speed of left ventricular assist devices (LVADs) cyclically may be useful to restore aortic pulsatility; however, the effects of this pulsation on right ventricular (RV) function are unknown. This study investigates the effects of direct ventricular interaction by quantifying the amount of wave energy created by RV contraction when axial and centrifugal LVADs are used to assist the left ventricle. In 4 anesthetized pigs, pressure and flow were measured in the main pulmonary artery and wave intensity analysis was used to identify and quantify the energy of waves created by the RV. The axial pump depressed the intensity of waves created by RV contraction compared with the centrifugal pump. In both pump designs, there were only minor and variable differences between the continuous and pulsed operation on RV function. The axial pump causes the RV to contract with less energy compared with a centrifugal design. Diminishing the ability of the RV to produce less energy translates to less pressure and flow produced, which may lead to LVAD-induced RV failure. The effects of pulsed LVAD operation on the RV appear to be minimal during acute observation of healthy hearts. Further study is necessary to uncover the effects of other modes of speed modulation with healthy and unhealthy hearts to determine if pulsed operation will benefit patients by reducing LVAD complications.

Investigation on the generation characteristic of pressure pulse wave signal during the measurement-while-drilling process

Science.gov (United States)

Changqing, Zhao; Kai, Liu; Tong, Zhao; Takei, Masahiro; Weian, Ren

2014-04-01

The mud-pulse logging instrument is an advanced measurement-while-drilling (MWD) tool and widely used by the industry in the world. In order to improve the signal transmission rate, ensure the accurate transmission of information and address the issue of the weak signal on the ground of oil and gas wells, the signal generator should send out the strong mud-pulse signals with the maximum amplitude. With the rotary valve pulse generator as the study object, the three-dimensional Reynolds NS equations and standard k - ɛ turbulent model were used as a mathematical model. The speed and pressure coupling calculation was done by simple algorithms to get the amplitudes of different rates of flow and axial clearances. Tests were done to verify the characteristics of the pressure signals. The pressure signal was captured by the standpiece pressure monitoring system. The study showed that the axial clearances grew bigger as the pressure wave amplitude value decreased and caused the weakening of the pulse signal. As the rate of flow got larger, the pressure wave amplitude would increase and the signal would be enhanced.

Following dynamic nuclear wave packets in N2,O2, and CO with few-cycle infrared pulses

International Nuclear Information System (INIS)

De, S.; Magrakvelidze, M.; Bocharova, I. A.; Ray, D.; Cao, W.; Li, H.; Wang, Z.; Laurent, G.; Thumm, U.; Ben-Itzhak, I.; Cocke, C. L.; Znakovskaya, I.; Kling, M. F.; Litvinyuk, I. V.

2011-01-01

We study the evolution of nuclear wave packets launched in molecular nitrogen, oxygen, and carbon monoxide by intense 8-fs infrared pulses. We use velocity map imaging to measure the momentum of the ion fragments when these wave packets are interrogated by a second such pulse after a variable time delay. Both quasibound and dissociative wave packets are observed. For the former, measurements of bound-state oscillations are used to identify the participating states and, in some cases, extract properties of the relevant potential-energy surfaces. Vibrational structure is resolved in both energy and oscillation frequencies for the cations of oxygen and carbon monoxide, displaying the same quantum wave-packet motion in both energy and time domains. In addition, vibrational structure is seen in the dication of carbon monoxide in a situation where the energy resolution by itself is inadequate to resolve the structure.

Following dynamic nuclear wave packets in N2,O2, and CO with few-cycle infrared pulses

Science.gov (United States)

de, S.; Magrakvelidze, M.; Bocharova, I. A.; Ray, D.; Cao, W.; Znakovskaya, I.; Li, H.; Wang, Z.; Laurent, G.; Thumm, U.; Kling, M. F.; Litvinyuk, I. V.; Ben-Itzhak, I.; Cocke, C. L.

2011-10-01

We study the evolution of nuclear wave packets launched in molecular nitrogen, oxygen, and carbon monoxide by intense 8-fs infrared pulses. We use velocity map imaging to measure the momentum of the ion fragments when these wave packets are interrogated by a second such pulse after a variable time delay. Both quasibound and dissociative wave packets are observed. For the former, measurements of bound-state oscillations are used to identify the participating states and, in some cases, extract properties of the relevant potential-energy surfaces. Vibrational structure is resolved in both energy and oscillation frequencies for the cations of oxygen and carbon monoxide, displaying the same quantum wave-packet motion in both energy and time domains. In addition, vibrational structure is seen in the dication of carbon monoxide in a situation where the energy resolution by itself is inadequate to resolve the structure.

Pulsed-wave transmitral Doppler do not diagnose moderate acute rejection after heart transplantation

NARCIS (Netherlands)

Mannaerts, H. F.; Simoons, M. L.; Balk, A. H.; Tijssen, J.; van der Borden, S. G.; Zondervan, P. E.; Mochtar, B.; Weimar, W.; Roelandt, J. R.

1993-01-01

The value of pulsed-wave transmitral Doppler for the diagnosis of moderate acute rejection was examined in a total of 347 Doppler recordings obtained in 32 consecutive cardiac allograft recipients. Serial Doppler examinations (median, 11 per patient; range, 1 to 23) were performed simultaneously

PULSED-WAVE TRANSMITRAL DOPPLER DO NOT DIAGNOSE MODERATE ACUTE REJECTION AFTER HEART-TRANSPLANTATION

NARCIS (Netherlands)

MANNAERTS, HF; SIMOONS, ML; BALK, AH; TIJSSEN, J; VANDERBORDEN, SG; ZONDERVAN, PE; MOCHTAR, B; WEIMAR, W; ROELANDT, [No Value

1993-01-01

The value of pulsed-wave transmitral Doppler for the diagnosis of moderate acute rejection was examined in a total of 347 Doppler recordings obtained in 32 consecutive cardiac allograft recipients. Serial Doppler examinations (median, 11 per patient; range, 1 to 23) were performed simultaneously

High-power TM01 millimeter wave pulse sensor in circular waveguide

International Nuclear Information System (INIS)

Wang Guang-Qiang; Zhu Xiang-Qin; Chen Zai-Gao; Wang Xue-Feng; Zhang Li-Jun

2015-01-01

By investigating the interaction of an n-type silicon sample with the TM 01 mode millimeter wave in a circular waveguide, a viable high-power TM 01 millimeter wave sensor is proposed. Based on the hot electron effect, the silicon sample serving as a sensing element (SE) and appropriately mounted on the inner wall of the circular waveguide is devoted to the on-line measurement of a high-power millimeter wave pulse. A three-dimensional parallel finite-difference time-domain method is applied to simulate the wave propagation within the measuring structure. The transverse electric field distribution, the dependences of the frequency response of the voltage standing-wave ratio (VSWR) in the circular waveguide, and the average electric field amplitude within the SE on the electrophysical parameters of the SE are calculated and analyzed in the frequency range of 300–400 GHz. As a result, the optimal dimensions and specific resistance of the SE are obtained, which provide a VSWR of no more than 2.0, a relative sensitivity around 0.0046 kW −1 fluctuating within ± 17.3%, and a maximum enduring power of about 4.3 MW. (paper)

Pulse Sign Separation Technique for the Received Bits in Wireless Ultra-Wideband Combination Approach

Directory of Open Access Journals (Sweden)

Rashid A. Fayadh

2014-01-01

Full Text Available When receiving high data rate in ultra-wideband (UWB technology, many users have experienced multiple-user interference and intersymbol interference in the multipath reception technique. Structures have been proposed for implementing rake receivers to enhance their capabilities by reducing the bit error probability (Pe, thereby providing better performances by indoor and outdoor multipath receivers. As a result, several rake structures have been proposed in the past to reduce the number of resolvable paths that must be estimated and combined. To achieve this aim, we suggest two maximal ratio combiners based on the pulse sign separation technique, such as the pulse sign separation selective combiner (PSS-SC and the pulse sign separation partial combiner (PSS-PC to reduce complexity with fewer fingers and to improve the system performance. In the combiners, a comparator was added to compare the positive quantity of positive pulses and negative quantities of negative pulses to decide whether the transmitted bit was 1 or 0. The Pe was driven by simulation for multipath environments for impulse radio time-hopping binary phase shift keying (TH-BPSK modulation, and the results were compared with those of conventional selective combiners (C-SCs and conventional partial combiners (C-PCs.

Temporal analysis of reflected optical signals for short pulse laser interaction with nonhomogeneous tissue phantoms

International Nuclear Information System (INIS)

Trivedi, Ashish; Basu, Soumyadipta; Mitra, Kunal

2005-01-01

The use of short pulse laser for minimally invasive detection scheme has become an indispensable tool in the technological arsenal of modern medicine and biomedical engineering. In this work, a time-resolved technique has been used to detect tumors/inhomogeneities in tissues by measuring transmitted and reflected scattered temporal optical signals when a short pulse laser source is incident on tissue phantoms. A parametric study involving different scattering and absorption coefficients of tissue phantoms and inhomogeneities, size of inhomogeneity as well as the detector position is performed. The experimental measurements are validated with a numerical solution of the transient radiative transport equation obtained by using discrete ordinates method. Thus, both simultaneous experimental and numerical studies are critical for predicting the optical properties of tissues and inhomogeneities from temporal scattered optical signal measurements

A comparison between the pathophysiology of multiple sclerosis and normal pressure hydrocephalus: is pulse wave encephalopathy a component of MS?

Science.gov (United States)

Bateman, Grant A; Lechner-Scott, Jeannette; Lea, Rodney A

2016-09-22

It has been suggested there is a chronic neurodegenerative disorder, underlying the pathophysiology of multiple sclerosis (MS), which is distinct from the more obvious immune-mediated attack on the white matter. Limited data exists indicating there is an alteration in pulse wave propagation within the craniospinal cavity in MS, similar to the findings in normal pressure hydrocephalus (NPH). It is hypothesized MS may harbor pulse wave encephalopathy. The purpose of this study is to compare blood flow and pulse wave measurements in MS patients with a cohort of NPH patients and control subjects, to test this hypothesis. Twenty patients with MS underwent magnetic resonance (MR) flow quantification techniques. Mean blood flow and stroke volume were measured in the arterial inflow and venous out flow from the sagittal (SSS) and straight sinus (ST). The arteriovenous delay (AVD) was defined. The results were compared with both age-matched controls and NPH patients. In MS there was a 35 % reduction in arteriovenous delay and a 5 % reduction in the percentage of the arterial inflow returning via the sagittal sinus compared to age matched controls. There was an alteration in pulse wave propagation, with a 26 % increase in arterial stroke volume but 30 % reduction in SSS and ST stroke volume. The AVD and blood flow changes were in the same direction to those of NPH patients. There are blood flow and pulsation propagation changes in MS patients which are similar to those of NPH patients. The findings would be consistent with an underlying pulse wave encephalopathy component in MS.

A hybrid stimulation strategy for suppression of spiral waves in cardiac tissue

Energy Technology Data Exchange (ETDEWEB)

Xu Binbin, E-mail: xubinbin@hotmail.fr [LE2I, CNRS UMR 5158, Universite de Bourgogne, Dijon (France); Jacquir, Sabir, E-mail: sjacquir@u-bourgogne.fr [LE2I, CNRS UMR 5158, Universite de Bourgogne, Dijon (France); Laurent, Gabriel; Bilbault, Jean-Marie [LE2I, CNRS UMR 5158, Universite de Bourgogne, Dijon (France); Binczak, Stephane, E-mail: stbinc@u-bourgogne.fr [LE2I, CNRS UMR 5158, Universite de Bourgogne, Dijon (France)

2011-08-15

Highlights: > Simulation of a cardiac tissue by a modified 2D FitzHugh-Nagumo model. > Stimulation of monophasic impulsions from a grid of electrodes to the cardiac tissue. > Propose a method by modifying the tissue's sodium channels and electrical stimulation. > The method leading to suppress spiral waves without generating new ones. > Optimal parameters of a successful suppression of spiral waves are investigated. - Abstract: Atrial fibrillation (AF) is the most common cardiac arrhythmia whose mechanisms are thought to be mainly due to the self perpetuation of spiral waves (SW). To date, available treatment strategies (antiarrhythmic drugs, radiofrequency ablation of the substrate, electrical cardioversion) to restore and to maintain a normal sinus rhythm have limitations and are associated with AF recurrences. The aim of this study was to assess a way of suppressing SW by applying multifocal electrical stimulations in a simulated cardiac tissue using a 2D FitzHugh-Nagumo model specially convenient for AF investigations. We identified stimulation parameters for successful termination of SW. However, SW reinduction, following the electrical stimuli, leads us to develop a hybrid strategy based on sodium channel modification for the simulated tissue.

Cavitation and shock waves emission on the rigid boundary of water under mid-IR nanosecond laser pulse excitation

Science.gov (United States)

Pushkin, A. V.; Bychkov, A. S.; Karabutov, A. A.; Potemkin, F. V.

2018-06-01

The processes of conversion of light energy into mechanical energy under mid-IR nanosecond laser excitation on a rigid boundary of water are investigated. Strong water absorption of Q-switched Cr:Yb:Ho:YSGG (2.85 µm, 6 mJ, 45 ns) laser radiation provides rapid energy deposition of ~8 kJ cm‑3 accompanied with strong mechanical transients. The evolution of shock waves and cavitation bubbles is studied using the technique of shadowgraphy and acoustic measurements, and the conversion efficiency into these energy channels for various laser fluence (0.75–2.0 J cm‑2) is calculated. For 6 mJ laser pulse with fluence of 2.0 J cm‑2, the conversion into shock wave energy reaches 67%. The major part of the shock wave energy (92%) is dissipated when the shock front travels the first 250 µm, and the remaining 8% is transferred to the acoustic far field. The calculated pressure in the vicinity of water-silicon interface is 0.9 GPa. Cavitation efficiency is significantly less and reaches up to 5% of the light energy. The results of the current study could be used in laser parameters optimization for micromachining and biological tissue ablation.

Experimental investigation of electron beam wave interactions utilising short pulses

International Nuclear Information System (INIS)

Wiggins, Samuel Mark

2000-01-01

Experiments have investigated the production of ultra-short electromagnetic pulses and their interaction with electrons in various resonant structures. Diagnostic systems used in the measurements included large bandwidth detection systems for capturing the short pulses. Deconvolution techniques have been applied to account for bandwidth limitation of the detection systems and to extract the actual pulse amplitudes and durations from the data. A Martin-Puplett interferometer has been constructed for use as a Fourier transform spectrometer. The growth of superradiant electromagnetic spikes from short duration (0.5-1.0 ns), high current (0.6-2.0 kA) electron pulses has been investigated in a Ka-band Cherenkov maser and Ka- and W-band backward wave oscillators (BWO). In the Cherenkov maser, radiation spikes were produced with a peak power ≤ 3 MW, a duration ≥ 70 ps and a bandwidth ≤ 19 %. It is shown that coherent spontaneous emission from the leading edge of the electron pulse drives these interactions, giving rise to self-amplified coherent spontaneous emission (SACSE). BWO spikes were produced with a peak power ≤ 63 MW and a pulse duration ∼ 250 ps in the Ka-band and ≤ 12 MW and ∼ 170 ps in the W-band. Evidence of superradiant evolution has been observed in the measurements of scaling laws such as power scaling with the current squared and duration scaling inversely with the fourth root of the power. An X-band free-electron maser amplifier, in which a short (1.0ns) injected radiation pulse interacts with a long (∼ 140 ns) electron beam, has been investigated. The interaction is shown to evolve in the linear regime. The peak output power was 320 kW, which corresponded to a gain, approximately constant across the band, of 42 dB. Changes to the spectrum, that occur when the input radiation pulse is injected into electrons with an energy gradient, have been analysed. (author)

Investigation of acoustic waves generated in an elastic solid by a pulsed ion beam and their application in a FIB based scanning ion acoustic microscope

International Nuclear Information System (INIS)

Akhmadaliev, C.

2004-12-01

The aim of this work is to investigate the acoustic wave generation by pulsed and periodically modulated ion beams in different solid materials depending on the beam parameters and to demonstrate the possibility to apply an intensity modulated focused ion beam (FIB) for acoustic emission and for nondestructive investigation of the internal structure of materials on a microscopic scale. The combination of a FIB and an ultrasound microscope in one device can provide the opportunity of nondestructive investigation, production and modification of micro- and nanostructures simultaneously. This work consists of the two main experimental parts. In the first part the process of elastic wave generation during the irradiation of metallic samples by a pulsed beam of energetic ions was investigated in an energy range from 1.5 to 10 MeV and pulse durations of 0.5-5 μs, applying ions with different masses, e.g. oxygen, silicon and gold, in charge states from 1 + to 4 + . The acoustic amplitude dependence on the ion beam parameters like the ion mass and energy, the ion charge state, the beam spot size and the pulse duration were of interest. This work deals with ultrasound transmitted in a solid, i.e. bulk waves, because of their importance for acoustic transmission microscopy and nondestructive inspection of internal structure of a sample. The second part of this work was carried out using the IMSA-100 FIB system operating in an energy range from 30 to 70 keV. The scanning ion acoustic microscope based on this FIB system was developed and tested. (orig.)

Investigation of acoustic waves generated in an elastic solid by a pulsed ion beam and their application in a FIB based scanning ion acoustic microscope

Energy Technology Data Exchange (ETDEWEB)

Akhmadaliev, C.

2004-12-01

The aim of this work is to investigate the acoustic wave generation by pulsed and periodically modulated ion beams in different solid materials depending on the beam parameters and to demonstrate the possibility to apply an intensity modulated focused ion beam (FIB) for acoustic emission and for nondestructive investigation of the internal structure of materials on a microscopic scale. The combination of a FIB and an ultrasound microscope in one device can provide the opportunity of nondestructive investigation, production and modification of micro- and nanostructures simultaneously. This work consists of the two main experimental parts. In the first part the process of elastic wave generation during the irradiation of metallic samples by a pulsed beam of energetic ions was investigated in an energy range from 1.5 to 10 MeV and pulse durations of 0.5-5 {mu}s, applying ions with different masses, e.g. oxygen, silicon and gold, in charge states from 1{sup +} to 4{sup +}. The acoustic amplitude dependence on the ion beam parameters like the ion mass and energy, the ion charge state, the beam spot size and the pulse duration were of interest. This work deals with ultrasound transmitted in a solid, i.e. bulk waves, because of their importance for acoustic transmission microscopy and nondestructive inspection of internal structure of a sample. The second part of this work was carried out using the IMSA-100 FIB system operating in an energy range from 30 to 70 keV. The scanning ion acoustic microscope based on this FIB system was developed and tested. (orig.)

Short pulse laser systems for biomedical applications

CERN Document Server

Mitra, Kunal

2017-01-01

This book presents practical information on the clinical applications of short pulse laser systems and the techniques for optimizing these applications in a manner that will be relevant to a broad audience, including engineering and medical students as well as researchers, clinicians, and technicians. Short pulse laser systems are useful for both subsurface tissue imaging and laser induced thermal therapy (LITT), which hold great promise in cancer diagnostics and treatment. Such laser systems may be used alone or in combination with optically active nanoparticles specifically administered to the tissues of interest for enhanced contrast in imaging and precise heating during LITT. Mathematical and computational models of short pulse laser-tissue interactions that consider the transient radiative transport equation coupled with a bio-heat equation considering the initial transients of laser heating were developed to analyze the laser-tissue interaction during imaging and therapy. Experiments were first performe...

Dual-pulse frequency compounded superharmonic imaging.

Science.gov (United States)

van Neer, Paul L M J; Danilouchkine, Mikhail G; Matte, Guillaume M; van der Steen, Anton F W; de Jong, Nico

2011-11-01

Tissue second-harmonic imaging is currently the default mode in commercial diagnostic ultrasound systems. A new modality, superharmonic imaging (SHI), combines the third through fifth harmonics originating from nonlinear wave propagation through tissue. SHI could further improve the resolution and quality of echographic images. The superharmonics have gaps between the harmonics because the transducer has a limited bandwidth of about 70% to 80%. This causes ghost reflection artifacts in the superharmonic echo image. In this work, a new dual-pulse frequency compounding (DPFC) method to eliminate these artifacts is introduced. In the DPFC SHI method, each trace is constructed by summing two firings with slightly different center frequencies. The feasibility of the method was established using a single-element transducer. Its acoustic field was modeled in KZK simulations and compared with the corresponding measurements obtained with a hydrophone apparatus. Subsequently, the method was implemented on and optimized for a setup consisting of an interleaved phased-array transducer (44 elements at 1 MHz and 44 elements at 3.7 MHz, optimized for echocardiography) and a programmable ultrasound system. DPFC SHI effectively suppresses the ghost reflection artifacts associated with imaging using multiple harmonics. Moreover, compared with the single-pulse third harmonic, DPFC SHI improved the axial resolution by 3.1 and 1.6 times at the -6-dB and -20-dB levels, respectively. Hence, DPFC offers the possibility of generating harmonic images of a higher quality at a cost of a moderate frame rate reduction.

Control of propagation characteristics of spin wave pulses via elastic and thermal effects

Energy Technology Data Exchange (ETDEWEB)

Gómez-Arista, Ivan [Centro de Ciencias Aplicadas y Desarrollo Tecnológico, Universidad Nacional Autónoma de México, CU, 04510 D.F., México (Mexico); Kolokoltsev, O., E-mail: oleg.kolokoltsev@ccadet.unam.mx [Centro de Ciencias Aplicadas y Desarrollo Tecnológico, Universidad Nacional Autónoma de México, CU, 04510 D.F., México (Mexico); Acevedo, A.; Qureshi, N. [Centro de Ciencias Aplicadas y Desarrollo Tecnológico, Universidad Nacional Autónoma de México, CU, 04510 D.F., México (Mexico); Ordóñez-Romero, César L. [Instituto de Física, Universidad Nacional Autónoma de México, CU, 04510 D.F., México (Mexico)

2017-05-01

A study of the magnetoelastic (ME) and thermal effects governing the phase (φ) and amplitude of magnetostatic surface spin wave (MSSW) pulses propagating in Ga:YIG/GGG and permalloy magnonic waveguides is presented. The ME effects were studied in a flexural configuration, under punctual mechanical force (F). Thermally induced ME and demagnetization phenomena were controlled by optically injected thermal power P{sub th}. It was determined that in an unclamped Ga:YIG waveguide, the force F that induces the phase shift Δφ=π, decreases by a quadratic law in the range from 1 mN to nN, and the P{sub th} at which Δφ=π decreases linearly from mW to μW as the waveguide volume decreases from mm{sup 3} to nm{sup 3}. For nano-volume waveguides the ME control energy (E{sub me}) can be of order of aJ, and the thermal control energy (ΔE{sub th}) can be as small as 50 fJ. The response time of these effects lies in the ns time scale. Both the mechanical and the thermo-magnetic forces provide an effective control of MSSW pulse amplitude, in addition to its phase shift. The thermo-magnetic effect allows one to realize variable delays of a MSSW pulse. - Highlights: • The Magneto-elastic (ME) and optically induced thermal effects governing the phase and amplitude of magnetostatic surface spin wave (MSSW) pulses propagating in Ga:YIG/GGG and permalloy magnonic waveguides are presented. • A mechanical force that causes phase shift Δφ=π for spin waves in the waveguides decreases by a quadratic law in the range from 1 mN to nN, and the optical power that induces the phase shift Δφ=π, decreases linearly from mW to μW as the waveguide volume decreases from mm{sup 3} to nm{sup 3}. • The response time of these effects can lie in the ns time scale.

Efficacy of intense pulse light therapy and tripple combination cream versus intense pulse light therapy and tripple combination cream alone in epidermal melasma treatment

International Nuclear Information System (INIS)

Shakeeb, N.; Noor, S.M.; Paracha, M.M.; Ullah, G.

2018-01-01

Objective:To compare the efficacy of intense pulse light therapy (IPL) and triple combination cream (TCC) versus intense pulse light therapy and triple combination cream alone in epidermal melasma treatment, downgrading MASI score to more than 10. Study Design:Randomized controlled trial. Place and Duration of Study:Dermatology Department, Lady Reading Hospital, Peshawar, from August 2014 to January 2015. Methodology:Patients of 18-45 years were included in the study with Fitzpatrick skin type II-V. Sample of 96 patients was divided in to three groups of 32 each, through consecutive (non-probability) sampling method. Detailed history was taken, Woods Lamp Examination done, and melasma area and severity index (MASI) score was calculated. TCC had to be applied daily at night for two months by group A patients while group B was consigned for IPL therapy fortnightly, and those in group C were given both for two months. Efficacy was compared by recalculating MASI score at treatment end as well as at follow-up after 4 weeks, using Chi-square test with significance at p < 0.05. Results:Male and female patients were 10 (31.2%) and 22 (68.8%) in group A, 7 (21.9%) and 25 (78.1%) in group B, while in group C were 12 (37.5%) and 20 (62.5%). The average age was 28.70 +8.70 years. MASI score reduction was achieved in 22 (68.8%) patients in group A; whereas, in 20 (62.5%) and 30(93.8%) patients in group B and C, respectively. Efficacy-wise distribution was significant (p=0.009). Conclusion:Intense pulse light therapy and triple combination cream are more efficacious in epidermal melasma treatment than intense pulse light therapy and triple combination cream alone. (author)

Numerical Investigation of Pulse Wave Propagation in Arteries Using Fluid Structure Interaction Capabilities

Directory of Open Access Journals (Sweden)

Hisham Elkenani

2017-01-01

Full Text Available The aim of this study is to present a reliable computational scheme to serve in pulse wave velocity (PWV assessment in large arteries. Clinicians considered it as an indication of human blood vessels’ stiffness. The simulation of PWV was conducted using a 3D elastic tube representing an artery. The constitutive material model specific for vascular applications was applied to the tube material. The fluid was defined with an equation of state representing the blood material. The onset of a velocity pulse was applied at the tube inlet to produce wave propagation. The Coupled Eulerian-Lagrangian (CEL modeling technique with fluid structure interaction (FSI was implemented. The scaling of sound speed and its effect on results and computing time is discussed and concluded that a value of 60 m/s was suitable for simulating vascular biomechanical problems. Two methods were used: foot-to-foot measurement of velocity waveforms and slope of the regression line of the wall radial deflection wave peaks throughout a contour plot. Both methods showed coincident results. Results were approximately 6% less than those calculated from the Moens-Korteweg equation. The proposed method was able to describe the increase in the stiffness of the walls of large human arteries via the PWV estimates.

Dual-pulse frequency compounded superharmonic imaging

NARCIS (Netherlands)

Neer, P.L.M.J. van; Danilouchkine, M.G.; Matte, G.M.; Steen, A.F.W. van der; Jong, N. de

2011-01-01

Tissue second-harmonic imaging is currently the default mode in commercial diagnostic ultrasound systems. A new modality, superharmonic imaging (SHI), combines the third through fifth harmonics originating from nonlinear wave propagation through tissue. SHI could further improve the resolution and

Nonlinear dynamics of shells conveying pulsatile flow with pulse-wave propagation. Theory and numerical results for a single harmonic pulsation

Science.gov (United States)

Tubaldi, Eleonora; Amabili, Marco; Païdoussis, Michael P.

2017-05-01

In deformable shells conveying pulsatile flow, oscillatory pressure changes cause local movements of the fluid and deformation of the shell wall, which propagate downstream in the form of a wave. In biomechanics, it is the propagation of the pulse that determines the pressure gradient during the flow at every location of the arterial tree. In this study, a woven Dacron aortic prosthesis is modelled as an orthotropic circular cylindrical shell described by means of the Novozhilov nonlinear shell theory. Flexible boundary conditions are considered to simulate connection with the remaining tissue. Nonlinear vibrations of the shell conveying pulsatile flow and subjected to pulsatile pressure are investigated taking into account the effects of the pulse-wave propagation. For the first time in literature, coupled fluid-structure Lagrange equations of motion for a non-material volume with wave propagation in case of pulsatile flow are developed. The fluid is modeled as a Newtonian inviscid pulsatile flow and it is formulated using a hybrid model based on the linear potential flow theory and considering the unsteady viscous effects obtained from the unsteady time-averaged Navier-Stokes equations. Contributions of pressure and velocity propagation are also considered in the pressure drop along the shell and in the pulsatile frictional traction on the internal wall in the axial direction. A numerical bifurcation analysis employs a refined reduced order model to investigate the dynamic behavior of a pressurized Dacron aortic graft conveying blood flow. A pulsatile time-dependent blood flow model is considered by applying the first harmonic of the physiological waveforms of velocity and pressure during the heart beating period. Geometrically nonlinear vibration response to pulsatile flow and transmural pulsatile pressure, considering the propagation of pressure and velocity changes inside the shell, is here presented via frequency-response curves, time histories, bifurcation

Mechanic effect of pulsed focused ultrasound in tumor and muscle tissue evaluated by MRI, histology, and microarray analysis

International Nuclear Information System (INIS)

Hundt, Walter; Yuh, Esther L.; Steinbach, Silke; Bednarski, Mark D.; Guccione, Samira

2010-01-01

The purpose of this study was to investigate the effect of pulsed high-intensity focused ultrasound (HIFU) to tumor and muscle tissue. Pulsed HIFU was applied to tumor and muscle tissue in C3H/Km mice. Three hours after HIFU treatment pre- and post-contrast T1-wt, T2-wt images and a diffusion-wt STEAM-sequence were obtained. After MR imaging, the animals were euthenized and the treated tumor and muscle was taken out for histology and functional genomic analysis. In the tumor tissue a slight increase of the diffusion coefficient could be found. In the muscle tissue T2 images showed increased signal intensity and post-contrast T1 showed a decreased contrast uptake in the center and a severe contrast uptake in the surrounding muscle tissue. A significant increase of the diffusion coefficient was found. Gene expression analysis revealed profound changes in the expression levels of 29 genes being up-regulated and 3 genes being down-regulated in the muscle tissue and 31 genes being up-regulated and 15 genes being down-regulated in the SCCVII tumor tissue. Seven genes were up-regulated in both tissue types. The highest up-regulated gene in the tumor and muscle tissue encoded for Mouse histone H2A.1 gene (FC = 13.2 ± 20.6) and Apolipoprotein E (FC = 12.8 ± 27.4) respectively MHC class III (FC = 83.7 ± 67.4) and hsp70 (FC = 75.3 ± 85.0). Immunoblot confirmed the presence of HSP70 protein in the muscle tissue. Pulsed HIFU treatment on tumor and muscle tissue results in dramatic changes in gene expression, indicating that the effect of pulsed HIFU is in some regard dependent and also independent of the tissue type.

Effects of extracorporeal shock wave lithotripsy on the kidney and perinephric tissues: CT evaluation

Energy Technology Data Exchange (ETDEWEB)

Song, Kounn Sik; Kim, Kun Sang; Kim, Sae Chul [College of Medicine, Chung-Ang University, Seoul (Korea, Republic of)

1987-12-15

Since the first successful treatment of the patient with renal stone by extracorporeal shock wave lithotripsy at the Institute for Surgical Research, West Germany, on February 7, 1980, extracorporeal shock wave lithotripsy (ESWL) has been a non-invasive technique for the treatment of the renal and ureteral calculi. In spite of the fact that the acoustic energy of the focused shock waves must pass through the soft tissues of back, perinephric tissues and renal parenchyme before reaching calculi, little is known about the effects of ESWL in the renal parenchyme and perinephric soft tissues. So we analyzed a pre and post-ESWL computed tomography scans of the kidneys in 130 patients treated at our hospital during a three month period to evaluate the effects of ESWL on the kidney and perinephric soft tissues.

Effects of extracorporeal shock wave lithotripsy on the kidney and perinephric tissues: CT evaluation

International Nuclear Information System (INIS)

Song, Kounn Sik; Kim, Kun Sang; Kim, Sae Chul

1987-01-01

Since the first successful treatment of the patient with renal stone by extracorporeal shock wave lithotripsy at the Institute for Surgical Research, West Germany, on February 7, 1980, extracorporeal shock wave lithotripsy (ESWL) has been a non-invasive technique for the treatment of the renal and ureteral calculi. In spite of the fact that the acoustic energy of the focused shock waves must pass through the soft tissues of back, perinephric tissues and renal parenchyme before reaching calculi, little is known about the effects of ESWL in the renal parenchyme and perinephric soft tissues. So we analyzed a pre and post-ESWL computed tomography scans of the kidneys in 130 patients treated at our hospital during a three month period to evaluate the effects of ESWL on the kidney and perinephric soft tissues

Arterial pulse wave velocity, inflammatory markers, pathological GH and IGF states, cardiovascular and cerebrovascular disease

Directory of Open Access Journals (Sweden)

Michael R Graham

2008-12-01

Full Text Available Michael R Graham1, Peter Evans2, Bruce Davies1, Julien S Baker11Health and Exercise Science Research Unit, Faculty of Health Sport and Science, University of Glamorgan, Pontypridd, Wales, United Kingdom; 2Royal Gwent Hospital, Newport, Gwent, United KingdomAbstract: Blood pressure (BP measurements provide information regarding risk factors associated with cardiovascular disease, but only in a specific artery. Arterial stiffness (AS can be determined by measurement of arterial pulse wave velocity (APWV. Separate from any role as a surrogate marker, AS is an important determinant of pulse pressure, left ventricular function and coronary artery perfusion pressure. Proximal elastic arteries and peripheral muscular arteries respond differently to aging and to medication. Endogenous human growth hormone (hGH, secreted by the anterior pituitary, peaks during early adulthood, declining at 14% per decade. Levels of insulin-like growth factor-I (IGF-I are at their peak during late adolescence and decline throughout adulthood, mirror imaging GH. Arterial endothelial dysfunction, an accepted cause of increased APWV in GH deficiency (GHD is reversed by recombinant human (rh GH therapy, favorably influencing the risk for atherogenesis. APWV is a noninvasive method for measuring atherosclerotic and hypertensive vascular changes increases with age and atherosclerosis leading to increased systolic blood pressure and increased left ventricular hypertrophy. Aerobic exercise training increases arterial compliance and reduces systolic blood pressure. Whole body arterial compliance is lowered in strength-trained individuals. Homocysteine and C-reactive protein are two infl ammatory markers directly linked with arterial endothelial dysfunction. Reviews of GH in the somatopause have not been favorable and side effects of treatment have marred its use except in classical GHD. Is it possible that we should be assessing the combined effects of therapy with rhGH and rh

Experimental investigation of drug delivery using a super pulse CO2 laser

International Nuclear Information System (INIS)

Khosroshahi, M. E.; Jafari, A.; Mansoori, S.

2006-01-01

We have carried out an experiment using a super long CO 2 laser pulse (10 ms) on simulated gelatin-ink model. The mechanism of laser-gelatin-ink model interaction was studied by photothermal deflection and time-resolved dynamics techniques and fast photography. It seems that the main operating mechanisms with super long CO 2 laser where the absorption coefficient of gelatin-ink model is high, are photothermal vaporization and photomechanical photophorosis and cavitation collapse. The drug molecules can be transported into the tissue bulk described by the Fick's law for a given cavity geometry and mechanical waves, unlike only by pure photomechanical waves (id est photo acoustically) as with short pulses.

Bright broadband coherent fiber sources emitting strongly blue-shifted resonant dispersive wave pulses

DEFF Research Database (Denmark)

Tu, Haohua; Lægsgaard, Jesper; Zhang, Rui

2013-01-01

We predict and realize the targeted wavelength conversion from the 1550-nm band of a fs Er:fiber laser to an isolated band inside 370-850 nm, corresponding to a blue-shift of 700-1180 nm. The conversion utilizes resonant dispersive wave generation in widely available optical fibers with good...... efficiency (~7%). The converted band has a large pulse energy (~1 nJ), high spectral brightness (~1 mW/nm), and broad Gaussian-like spectrum compressible to clean transform-limited ~17 fs pulses. The corresponding coherent fiber sources open up portable applications of optical parametric oscillators and dual......-output synchronized ultrafast lasers....

Decreased memory loss associated with right unilateral ultra-brief pulse wave ECT.

Science.gov (United States)

Kim, Suck Won; Grant, Jon E; Rittberg, Barry R; Simon, John E; Vine, Craig J; Schulz, S Charles

2007-01-01

The purpose of this brief article is to share with our colleagues in the psychiatric community and other physicians information about the efficacy of an emerging new method of electroconvulsive therapy (ECT) that shows advantages over existing treatments for depression. Patients treated with the method, ultra-brief pulse wave ECT, have less memory loss and confusion than those treated with longer-duration ECT.

Investigation of ultrashort-pulsed laser on dental hard tissue

Science.gov (United States)

Uchizono, Takeyuki; Awazu, Kunio; Igarashi, Akihiro; Kato, Junji; Hirai, Yoshito

2007-02-01

Ultrashort-pulsed laser (USPL) can ablate various materials with precious less thermal effect. In laser dentistry, to solve the problem that were the generation of crack and carbonized layer by irradiating with conventional laser such as Er:YAG and CO II laser, USPL has been studied to ablate dental hard tissues by several researchers. We investigated the effectiveness of ablation on dental hard tissues by USPL. In this study, Ti:sapphire laser as USPL was used. The laser parameter had the pulse duration of 130 fsec, 800nm wavelength, 1KHz of repetition rate and the average power density of 90~360W/cm2. Bovine root dentin plates and crown enamel plates were irradiated with USPL at 1mm/sec using moving stage. The irradiated samples were analyzed by SEM, EDX, FTIR and roughness meter. In all irradiated samples, the cavity margin and wall were sharp and steep, extremely. In irradiated dentin samples, the surface showed the opened dentin tubules and no smear layer. The Ca/P ratio by EDX measurement and the optical spectrum by FTIR measurement had no change on comparison irradiated samples and non-irradiated samples. These results confirmed that USPL could ablate dental hard tissue, precisely and non-thermally. In addition, the ablation depths of samples were 10μm, 20μm, and 60μm at 90 W/cm2, 180 W/cm2, and 360 W/cm2, approximately. Therefore, ablation depth by USPL depends on the average power density. USPL has the possibility that can control the precision and non-thermal ablation with depth direction by adjusting the irradiated average power density.

Effects of pulsed mid-IR lasers on bovine knee joint tissues

Science.gov (United States)

Vari, Sandor G.; Shi, Wei-Qiang; Pergadia, Vani R.; Duffy, J. T.; Miller, J. M.; van der Veen, Maurits J.; Weiss, Andrew B.; Fishbein, Michael C.; Grundfest, Warren S.

1993-07-01

We investigated the effect of varying Tm:YAG (2.014 micrometers ) and Ho:YAG (2.130 micrometers ) laser parameters on ablation rate and consequent thermal damage. Mid-infrared wavelengths are strongly absorbed by most biological tissues due to the tissue's high water content. The ablation rate of fresh bovine knee joint tissues (fibrous cartilage, hyaline cartilage, and bone) in saline was assessed as a function of radiant exposure (160 - 950 J/cm2), at pulse widths of 200 microsecond(s) ec for Tm:YAG and 250 microsecond(s) ec for Ho:YAG and a repetition rate of 2 Hz. All tissues used in this study could be efficiently ablated using two micron lasers. The mechanism of action is likely related to the formation and collapse of cavitation bubbles, associated with mid-infrared lasers. We concluded that the Tm:YAG and Ho:YAG lasers are capable of effective knee joint tissue ablation.

Non-invasive aortic systolic pressure and pulse wave velocity estimation in a primary care setting: An in silico study.

Science.gov (United States)

Guala, Andrea; Camporeale, Carlo; Ridolfi, Luca; Mesin, Luca

2017-04-01

Everyday clinical cardiovascular evaluation is still largely based on brachial systolic and diastolic pressures. However, several clinical studies have demonstrated the higher diagnostic capacities of the aortic pressure, as well as the need to assess the aortic mechanical properties (e.g., by measuring the aortic pulse wave velocity). In order to fill this gap, we propose to exploit a set of easy-to-obtain physical characteristics to estimate the aortic pressure and pulse wave velocity. To this aim, a large population of virtual subjects is created by a validated mathematical model of the cardiovascular system. Quadratic regressive models are then fitted and statistically selected in order to obtain reliable estimations of the aortic pressure and pulse wave velocity starting from the knowledge of the subject age, height, weight, brachial pressure, photoplethysmographic measures and either electrocardiogram or phonocardiogram. The results are very encouraging and foster clinical studies aiming to apply a similar technique to a real population. Copyright © 2017 IPEM. Published by Elsevier Ltd. All rights reserved.

Upconversion imaging using short-wave infrared picosecond pulses

DEFF Research Database (Denmark)

Mathez, Morgan David; Rodrigo, Peter John; Tidemand-Lichtenberg, Peter

2017-01-01

beam diameter to upconvert a wider range of signal spatial frequencies in the crystal. The 1877 nm signal is converted into 849 nm—enabling an image to be acquired by a silicon CCD camera. The measured size of the smallest resolvable element of this imaging system is consistent with the value predicted...... repetition rate of 21.7 MHz. Due to synchronization of high peak-power pulses, efficient upconversion is achieved in a single-pass setup that employs a bulk lithium niobate crystal. Optimizing the temporal overlap of the pulses for high upconversion efficiency enables us to exploit a relatively large pump...... by an improved model that considers the combined image blurring effect due to finite pump beam size, thick nonlinear crystal, and polychromatic infrared illumination....

Nonlinear scattering in hard tissue studied with ultrashort laser pulses

International Nuclear Information System (INIS)

Eichler, J.; Kim, B.M.

2002-01-01

The back-scattered spectrum of ultrashort laser pulses (800 nm, 0.2 ps) was studied in human dental and other hard tissues in vitro below the ablation threshold. Frequency doubled radiation (SHG), frequency tripled radiation and two-photon fluorescence were detected. The relative yield for these processes was measured for various pulse energies. The dependence of the SHG signal on probe thickness was determined in forward and back scattering geometry. SHG is sensitive to linear polarization of the incident laser radiation. SHG in human teeth was studied in vitro showing larger signals in dentin than in cementum and enamel. In carious areas no SHG signal could be detected. Possible applications of higher harmonic radiation for diagnostics and microscopy are discussed. (orig.)

Generation of spin waves by a train of fs-laser pulses: a novel approach for tuning magnon wavelength

OpenAIRE

Savochkin, I. V.; J?ckl, M.; Belotelov, V. I.; Akimov, I. A.; Kozhaev, M. A.; Sylgacheva, D. A.; Chernov, A. I.; Shaposhnikov, A. N.; Prokopov, A. R.; Berzhansky, V. N.; Yakovlev, D. R.; Zvezdin, A. K.; Bayer, M.

2017-01-01

Currently spin waves are considered for computation and data processing as an alternative to charge currents. Generation of spin waves by ultrashort laser pulses provides several important advances with respect to conventional approaches using microwaves. In particular, focused laser spot works as a point source for spin waves and allows for directional control of spin waves and switching between their different types. For further progress in this direction it is important to manipulate with ...

Shock wave interaction with pulsed glow discharge and afterglow plasmas

International Nuclear Information System (INIS)

Podder, N.K.; LoCascio, A.C.

2009-01-01

Acoustic shock waves are launched by the spark-discharge of a high voltage capacitor in pulsed glow discharge and afterglow plasmas. The glow discharge section of the shock tube is switched on for a period of less than one second at a time, during which a shock wave is launched starting with a large delay between the plasma switch-on and the shock-launch. In the subsequent runs this delay is decremented in equal time intervals up to the plasma switch-on time. A photo acoustic deflection method sensitive to the density gradient of the shock wave is used to study the propagating shock structure and velocity in the igniting plasma. A similar set of measurements are also performed at the plasma switch-off, in which the delay time is incremented in equal time intervals from the plasma switch-off time until the afterglow plasma fully neutralizes itself into the room-temperature gas. Thus, complete time histories of the shock wave propagation in the igniting plasma, as well as in the afterglow plasma, are produced. In the igniting plasma, the changes in the shock-front velocity and dispersion are found to be a strong non-linear function of delay until a saturation point is reached. On the other hand, in the afterglow plasma the trend has been opposite and reversing towards the room temperature values. The observed shock wave properties in both igniting and afterglow plasmas correlate well with the inferred temperature changes in the two plasmas

Evaluating temperature changes of brain tissue due to induced heating of cell phone waves

Directory of Open Access Journals (Sweden)

Farhad Forouharmajd

2018-01-01

Full Text Available Background: Worries have recently been increased in the absorption of radiofrequency waves and their destructing effects on human health by increasing use of cell phones (mobile phones. This study performed to determine the thermal changes due to mobile phone radio frequency waves in gray and white brain tissue. Methods: This study is an empirical study, where the thermal changes of electromagnetic waves resulted from cell phones (900 MHZ, specific absorption rate for head 1.18 w/kg on the 15 brain tissue of a cow were analyzed in a compartment with three different thickness of 2 mm, 12 mm, and 22 mm, for 15 min. The Lutron thermometer (model: MT-917 with 0.01°C precision was used for measuring the tissue temperature. For each thickness was measured three times. Data analysis is done by Lutron and MATLAB software packages. Results: In confronting of the tissue with the cell phone, the temperature was increased by 0.53°C in the 2 mm thickness that is the gray matter of the brain, increased by 0.99°C in the 12 mm thickness, and also increased by 0.92°C in the 22 mm thickness. Brain temperature showed higher rates than the base temperature after 15 min of confrontation with cell phone waves in all the three thicknesses. Conclusions: Cell phone radiated radio frequency waves were effective on increasing brain tissue temperature, and this temperature increase has cumulative effect on the tissue, being higher, for some time after the confrontation than the time with no confrontation.

Elimination of spiral waves in cardiac tissue by multiple electrical shocks

NARCIS (Netherlands)

Panfilov, A.V.; Müller, Stefan C.; Zykov, Vladimir S.; Keener, James P.

1999-01-01

We study numerically the elimination of a spiral wave in cardiac tissue by application of multiple shocks of external current. To account for the effect of shocks we apply a recently developed theory for the interaction of the external current with cardiac tissue. We compare two possible feedback

Soliton radiation beat analysis of optical pulses generated from two continuous-wave lasers

Science.gov (United States)

Zajnulina, M.; Böhm, M.; Blow, K.; Rieznik, A. A.; Giannone, D.; Haynes, R.; Roth, M. M.

2015-10-01

We propose a fibre-based approach for generation of optical frequency combs (OFCs) with the aim of calibration of astronomical spectrographs in the low and medium-resolution range. This approach includes two steps: in the first step, an appropriate state of optical pulses is generated and subsequently moulded in the second step delivering the desired OFC. More precisely, the first step is realised by injection of two continuous-wave (CW) lasers into a conventional single-mode fibre, whereas the second step generates a broad OFC by using the optical solitons generated in step one as initial condition. We investigate the conversion of a bichromatic input wave produced by two initial CW lasers into a train of optical solitons, which happens in the fibre used as step one. Especially, we are interested in the soliton content of the pulses created in this fibre. For that, we study different initial conditions (a single cosine-hump, an Akhmediev breather, and a deeply modulated bichromatic wave) by means of soliton radiation beat analysis and compare the results to draw conclusion about the soliton content of the state generated in the first step. In case of a deeply modulated bichromatic wave, we observed the formation of a collective soliton crystal for low input powers and the appearance of separated solitons for high input powers. An intermediate state showing the features of both, the soliton crystal and the separated solitons, turned out to be most suitable for the generation of OFC for the purpose of calibration of astronomical spectrographs.

Experimental Observation of Generation of Superradiance Pulses in the Process of Backscattering of Pump Wave on the Intense Electron Bunch

CERN Document Server

Ginzburg, N S; Denisov, G G; Rozental, R M; Sergeev, A; Zotova, I V

2005-01-01

Recently significant progress was archived in the generation of multimegawatt subnanosecond pulses in millimeter wave band utilizing the cyclotron and Cherenkov mechanisms of superradiance (SR) [1,2]. We study the novel mechanism of SR when the powerful pumping wave undergoes the stimulated back scattering on the intense electron bunch. Due to the Doppler up shift the radiation frequency can significantly exceed the frequency of the pumping wave. With the relativistic microwave generator as a pumping wave source such a mechanism can be used for generation of the powerful pulse radiation in the short millimeter and submillimeter wave bands. Experiments on the observation of the stimulated scattering in the superradiance regime were carried out at Institute of Electrophysics RAS with two synchronized accelerators. The 4 ns electron beam from the first accelerator is used for generation of the 38 GHz 100 MW pumping wave which subsequently scattered on the subnanosecond 250 keV 1 kA electron bunch produced by the...

Feedback Interactions of Polymerized Actin with the Cell Membrane: Waves, Pulses, and Oscillations

Science.gov (United States)

Carlsson, Anders

Polymerized filaments of the protein actin have crucial functions in cell migration, and in bending the cell membrane to drive endocytosis or the formation of protrusions. The nucleation and polymerization of actin filaments are controlled by upstream agents in the cell membrane, including nucleation-promoting factors (NPFs) that activate the Arp2/3 complex to form new branches on pre-existing filaments. But polymerized actin (F-actin) also feeds back on the assembly of NPFs. We explore the effects of the resulting feedback loop of F-actin and NPFs on two phenomena: actin pulses that drive endocytosis in yeast, and actin waves traveling along the membrane of several cell types. In our model of endocytosis in yeast, the actin network is grown explicitly in three dimensions, exerts a negative feedback interaction on localized patch of NPFs in the membrane, and bends the membrane by exerting a distribution of forces. This model explains observed actin and NPF pulse dynamics, and the effects of several interventions including i) NPF mutations, ii) inhibition of actin polymerization, and iii) deletion of a protein that allows F-actin to bend the cell membrane. The model predicts that mutation of the active region of an NPF will enhance the accumulation of that NPF, and we confirm this prediction by quantitative fluorescence microscopy. For actin waves, we treat a similar model, with NPFs distributed over a larger region of the cell membrane. This model naturally generates actin waves, and predicts a transition from wave behavior to spatially localized oscillations when NPFs are confined to a small region. We also predict a transition from waves to static polarization as the negative-feedback coupling between F-actin and the NPFs is reduced. Supported by NIGMS Grant R01 GM107667.

Generalized min-max bound-based MRI pulse sequence design framework for wide-range T1 relaxometry: A case study on the tissue specific imaging sequence.

Directory of Open Access Journals (Sweden)

Yang Liu

Full Text Available This paper proposes a new design strategy for optimizing MRI pulse sequences for T1 relaxometry. The design strategy optimizes the pulse sequence parameters to minimize the maximum variance of unbiased T1 estimates over a range of T1 values using the Cramér-Rao bound. In contrast to prior sequences optimized for a single nominal T1 value, the optimized sequence using our bound-based strategy achieves improved precision and accuracy for a broad range of T1 estimates within a clinically feasible scan time. The optimization combines the downhill simplex method with a simulated annealing process. To show the effectiveness of the proposed strategy, we optimize the tissue specific imaging (TSI sequence. Preliminary Monte Carlo simulations demonstrate that the optimized TSI sequence yields improved precision and accuracy over the popular driven-equilibrium single-pulse observation of T1 (DESPOT1 approach for normal brain tissues (estimated T1 700-2000 ms at 3.0T. The relative mean estimation error (MSE for T1 estimation is less than 1.7% using the optimized TSI sequence, as opposed to less than 7.0% using DESPOT1 for normal brain tissues. The optimized TSI sequence achieves good stability by keeping the MSE under 7.0% over larger T1 values corresponding to different lesion tissues and the cerebrospinal fluid (up to 5000 ms. The T1 estimation accuracy using the new pulse sequence also shows improvement, which is more pronounced in low SNR scenarios.

Cryosurgery with Pulsed Electric Fields

Science.gov (United States)

Daniels, Charlotte S.; Rubinsky, Boris

2011-01-01

This study explores the hypothesis that combining the minimally invasive surgical techniques of cryosurgery and pulsed electric fields will eliminate some of the major disadvantages of these techniques while retaining their advantages. Cryosurgery, tissue ablation by freezing, is a well-established minimally invasive surgical technique. One disadvantage of cryosurgery concerns the mechanism of cell death; cells at high subzero temperature on the outer rim of the frozen lesion can survive. Pulsed electric fields (PEF) are another minimally invasive surgical technique in which high strength and very rapid electric pulses are delivered across cells to permeabilize the cell membrane for applications such as gene delivery, electrochemotherapy and irreversible electroporation. The very short time scale of the electric pulses is disadvantageous because it does not facilitate real time control over the procedure. We hypothesize that applying the electric pulses during the cryosurgical procedure in such a way that the electric field vector is parallel to the heat flux vector will have the effect of confining the electric fields to the frozen/cold region of tissue, thereby ablating the cells that survive freezing while facilitating controlled use of the PEF in the cold confined region. A finite element analysis of the electric field and heat conduction equations during simultaneous tissue treatment with cryosurgery and PEF (cryosurgery/PEF) was used to study the effect of tissue freezing on electric fields. The study yielded motivating results. Because of decreased electrical conductivity in the frozen/cooled tissue, it experienced temperature induced magnified electric fields in comparison to PEF delivered to the unfrozen tissue control. This suggests that freezing/cooling confines and magnifies the electric fields to those regions; a targeting capability unattainable in traditional PEF. This analysis shows how temperature induced magnified and focused PEFs could be used to

Cryosurgery with pulsed electric fields.

Directory of Open Access Journals (Sweden)

Charlotte S Daniels

Full Text Available This study explores the hypothesis that combining the minimally invasive surgical techniques of cryosurgery and pulsed electric fields will eliminate some of the major disadvantages of these techniques while retaining their advantages. Cryosurgery, tissue ablation by freezing, is a well-established minimally invasive surgical technique. One disadvantage of cryosurgery concerns the mechanism of cell death; cells at high subzero temperature on the outer rim of the frozen lesion can survive. Pulsed electric fields (PEF are another minimally invasive surgical technique in which high strength and very rapid electric pulses are delivered across cells to permeabilize the cell membrane for applications such as gene delivery, electrochemotherapy and irreversible electroporation. The very short time scale of the electric pulses is disadvantageous because it does not facilitate real time control over the procedure. We hypothesize that applying the electric pulses during the cryosurgical procedure in such a way that the electric field vector is parallel to the heat flux vector will have the effect of confining the electric fields to the frozen/cold region of tissue, thereby ablating the cells that survive freezing while facilitating controlled use of the PEF in the cold confined region. A finite element analysis of the electric field and heat conduction equations during simultaneous tissue treatment with cryosurgery and PEF (cryosurgery/PEF was used to study the effect of tissue freezing on electric fields. The study yielded motivating results. Because of decreased electrical conductivity in the frozen/cooled tissue, it experienced temperature induced magnified electric fields in comparison to PEF delivered to the unfrozen tissue control. This suggests that freezing/cooling confines and magnifies the electric fields to those regions; a targeting capability unattainable in traditional PEF. This analysis shows how temperature induced magnified and focused

A pulsed single-frequency Nd:GGG/BaWO4 Raman laser

Science.gov (United States)

Liu, Zhaojun; Men, Shaojie; Cong, Zhenhua; Qin, Zengguang; Zhang, Xingyu; Zhang, Huaijin

2018-04-01

A single-frequency pulsed laser at 1178.3 nm was demonstrated in a crystalline Raman laser. A crystal combination of Nd:GGG and BaWO4 was selected to realize Raman conversion from a 1062.5 nm fundamental wave to a 1178.3 nm Stokes wave. An entangled cavity was specially designed to form an intracavity Raman configuration. Single-longitudinal-mode operation was realized by introducing two Fabry-Perot etalons into the Raman laser cavity. This laser operated at a pulse repetition rate of 50 Hz with 2 ms long envelopes containing micro pulses at a 30 kHz repetition rate. The highest output power was 41 mW with the micro pulse duration of 15 ns. The linewidth was measured to be less than 130 MHz.

Electromagnetic wave collapse in a radiation background

International Nuclear Information System (INIS)

Marklund, Mattias; Brodin, Gert; Stenflo, Lennart

2003-01-01

The nonlinear interaction, due to quantum electrodynamical (QED) effects between an electromagnetic pulse and a radiation background, is investigated by combining the methods of radiation hydrodynamics with the QED theory for photon-photon scattering. For the case of a single coherent electromagnetic pulse, we obtain a Zakharov-like system, where the radiation pressure of the pulse acts as a driver of acoustic waves in the photon gas. For a sufficiently intense pulse and/or background energy density, there is focusing and the subsequent collapse of the pulse. The relevance of our results for various astrophysical applications are discussed

Judgment value of brachial-ankle pulse wave velocity for lesion severity in hypertension patients with coronary arteriosclerosis

Directory of Open Access Journals (Sweden)

Zhong Zhao

2016-07-01

Full Text Available Objective: To analyze the judgment value of brachial-ankle pulse wave velocity for lesion severity in hypertension patients with coronary arteriosclerosis. Methods: A total of 100 cases of hypertension patients with coronary arteriosclerosis who received physical examination in Physical Examination Centre of our hospital were collected as research subjects of observation group, 100 cases patients with primary hypertension alone who received treatment in our hospital during the same period were selected as control group, brachial-ankle pulse wave velocity and ultrasound coronary area were detected, serum was collected to detect the levels of coronary arteriosclerosis illness-related indicators in it, and the judgment value of brachialankle pulse wave velocity for coronary arteriosclerosis severity was further analyzed. Results: PWV value of observation group was higher than that of control group while ABI value was lower than that of control group; intravascular ultrasound inspection showed that blood vessel volume, lumen volume and plaque volume of observation group were larger than those of control group; serum Hcy, Ox-LDL and ApoB/ApoA1 values of observation group were higher than those of control group while APN value was lower than that of control group; serum Lp-PLA2, sTWEAK, CML and bFGF values of observation group were higher than those of control group while secKlotho, Chrelin and MPO values were lower than those of control group; PWV and ABI values were directly correlated with disease severity-related factors. Conclusions: Brachial-ankle pulse wave velocity can effectively judge the lesion severity of hypertension patients with coronary arteriosclerosis, can be used as one of the accurate indicators to guide treatment and judge prognosis in clinical practice, and has important clinical value.

Signal-Pressure Curves of Cascaded Four-Wave Mixing in Gas-Filled Capillary by fs Pulses

International Nuclear Information System (INIS)

Chen Baozhen; Huang Zuqia

2005-01-01

The theoretical framework for the cascaded four waves mixing (CFWM) in gas-filled capillary by fs pulses is constructed. Based on the theoretical framework, the signal-pressure curves (SPC) of the CFWM in gas-filled capillary by fs pulses are calculated. With a comparison between the theoretical and experimental SPC we have discussed the influence of the walk-off and phase modulation on the SPC. At the same time, we have discussed the possible origin of the first three peaks of the SPC.

The Clinical Efficacy of Autologous Platelet-Rich Plasma Combined with Ultra-Pulsed Fractional CO2 Laser Therapy for Facial Rejuvenation.

Science.gov (United States)

Hui, Qiang; Chang, Peng; Guo, Bingyu; Zhang, Yu; Tao, Kai

2017-02-01

Ultra-pulsed fractional CO 2 laser is an efficient, precise, and safe therapeutic intervention for skin refreshing, although accompanied with prolonged edema and erythema. In recent years, autologous platelet-rich plasma (PRP) has been proven to promote wound and soft tissue healing and collagen regeneration. To investigate whether the combination of PRP and ultra-pulsed fractional CO 2 laser had a synergistic effect on therapy for facial rejuvenation. Totally, 13 facial aging females were treated with ultra-pulsed fractional CO 2 laser. One side of the face was randomly selected as experimental group and injected with PRP, the other side acted as the control group and was injected with physiological saline at the same dose. Comprehensive assessment of clinical efficacy was performed by satisfaction scores, dermatologists' double-blind evaluation and the VISIA skin analysis system. After treatment for 3 months, subjective scores of facial wrinkles, skin texture, and skin elasticity were higher than that in the control group. Similarly, improvement of skin wrinkles, texture, and tightness in the experimental group was better compared with the control group. Additionally, the total duration of erythema, edema, and crusting was decreased, in the experimental group compared with the control group. PRP combined with ultra-pulsed fractional CO 2 laser had a synergistic effect on facial rejuvenation, shortening duration of side effects, and promoting better therapeutic effect.

Pulmonary artery pulse pressure and wave reflection in chronic pulmonary thromboembolism and primary pulmonary hypertension.

Science.gov (United States)

Castelain, V; Hervé, P; Lecarpentier, Y; Duroux, P; Simonneau, G; Chemla, D

2001-03-15

The purpose of this time-domain study was to compare pulmonary artery (PA) pulse pressure and wave reflection in chronic pulmonary thromboembolism (CPTE) and primary pulmonary hypertension (PPH). Pulmonary artery pressure waveform analysis provides a simple and accurate estimation of right ventricular afterload in the time-domain. Chronic pulmonary thromboembolism and PPH are both responsible for severe pulmonary hypertension. Chronic pulmonary thromboembolism and PPH predominantly involve proximal and distal arteries, respectively, and may lead to differences in PA pressure waveform. High-fidelity PA pressure was recorded in 14 patients (7 men/7 women, 46 +/- 14 years) with CPTE (n = 7) and PPH (n = 7). We measured thermodilution cardiac output, mean PA pressure (MPAP), PA pulse pressure (PAPP = systolic - diastolic PAP) and normalized PAPP (nPAPP = PPAP/MPAP). Wave reflection was quantified by measuring Ti, that is, the time between pressure upstroke and the systolic inflection point (Pi), deltaP, that is, the systolic PAP minus Pi difference, and the augmentation index (deltaP/PPAP). At baseline, CPTE and PPH had similar cardiac index (2.4 +/- 0.4 vs. 2.5 +/- 0.5 l/min/m2), mean PAP (59 +/- 9 vs. 59 +/- 10 mm Hg), PPAP (57 +/- 13 vs. 53 +/- 13 mm Hg) and nPPAP (0.97 +/- 0.16 vs. 0.89 +/- 0.13). Chronic pulmonary thromboembolism had shorter Ti (90 +/- 17 vs. 126 +/- 16 ms, p PPAP (0.26 +/- 0.01 vs. 0.09 +/- 0.07, p < 0.01). Our study indicated that: 1) CPTE and PPH with severe pulmonary hypertension had similar PA pulse pressure, and 2) wave reflection is elevated in both groups, and CPTE had increased and anticipated wave reflection as compared with PPH, thus suggesting differences in the pulsatile component of right ventricular afterload.

Electromagnetic pulses, localized and causal

Science.gov (United States)

Lekner, John

2018-01-01

We show that pulse solutions of the wave equation can be expressed as time Fourier superpositions of scalar monochromatic beam wave functions (solutions of the Helmholtz equation). This formulation is shown to be equivalent to Bateman's integral expression for solutions of the wave equation, for axially symmetric solutions. A closed-form one-parameter solution of the wave equation, containing no backward-propagating parts, is constructed from a beam which is the tight-focus limit of two families of beams. Application is made to transverse electric and transverse magnetic pulses, with evaluation of the energy, momentum and angular momentum for a pulse based on the general localized and causal form. Such pulses can be represented as superpositions of photons. Explicit total energy and total momentum values are given for the one-parameter closed-form pulse.

Impact of ADMA, endothelial progenitor cells and traditional cardiovascular risk factors on pulse wave velocity among prediabetic individuals

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Protopsaltis Ioannis

2012-11-01

Full Text Available Abstract Background Central arterial stiffness represents a well-established predictor of cardiovascular disease. Decreased circulating endothelial progenitor cells (EPCs, increased asymmetric dimethyl-arginine (ADMA levels, traditional cardiovascular risk factors and insulin resistance have all been associated with increased arterial stiffness. The correlations of novel and traditional cardiovascular risk factors with central arterial stiffness in prediabetic individuals were investigated in the present study. Methods The study population consisted of 53 prediabetic individuals. Individuals were divided into groups of isolated impaired fasting glucose (IFG, isolated impaired glucose tolerance (IGT and combined IGT-IFG. Age, sex, family history of diabetes, smoking history, body mass index (BMI, waist to hip ratio (WHR, waist circumference (WC, blood pressure, lipid profile, levels of high sensitive C-reactive protein (hsCRP, glomerular filtration rate (GFR, and history of antihypertensive or statin therapy were obtained from all participants. Insulin resistance was evaluated using the Homeostatic Model Assessment (HOMA-IR. Carotid -femoral pulse wave velocity was used as an index of arterial stiffness. Circulating EPC count and ADMA serum levels were also determined. Results Among studied individuals 30 (56.6% subjects were diagnosed with isolated IFG, 9 (17% with isolated IGT (17% and 14 with combined IFG-IGT (26.4%. In univariate analysis age, mean blood pressure, fasting glucose, total cholesterol, LDL cholesterol, and ADMA levels positively correlated with pulse-wave velocity while exercise and GFR correlated negatively. EPC count did not correlate with PWV. In multivariate stepwise regression analysis PWV correlated independently and positively with LDL-Cholesterol (low density lipoprotein and ADMA levels and negatively with exercise. Conclusions Elevated ADMA and LDL-C levels are strongly associated with increased arterial stiffness among

Pulse wave velocity is associated with cognitive impairment in hemodialysis patients.

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Angermann, Susanne; Baumann, Marcus; Wassertheurer, Siegfried; Mayer, Christopher Clemens; Steubl, Dominik; Hauser, Christine; Suttmann, Yana; Reichelt, Anna-Lena; Satanovskij, Robin; Lorenz, Georg; Lukas, Moritz; Haller, Bernhard; Heemann, Uwe; Grimmer, Timo; Schmaderer, Christoph

2017-07-01

Cognitive impairment in hemodialysis patients is common and associated with adverse outcomes. So far, the underlying pathogenesis remains unclear. Therefore, we examined the potential relationship between cognitive impairment and three different categories of risk factors with particular focus on arterial stiffness measured by pulse wave velocity (PWV). A total of 201 chronic hemodialysis patients underwent cognitive testing under standardized conditions using the Montreal Cognitive Assessment (MoCA). Demographic data including cardiovascular risk factors, dialysis-associated factors as well as factors related to chronic kidney disease (CKD) were analyzed. To account for arterial stiffness, PWV was measured by ambulatory blood pressure monitoried with an oscillometric device that records brachial blood pressure along with pulse waves. In our cohort, 60.2% of patients showed pathological MoCA test results indicating cognitive impairment. PWV was significantly associated with cognitive impairment apart from age, educational level, diabetes, and hypercholesterolemia. High prevalence of cognitive impairment in hemodialysis patients was confirmed. For the first time, an association between cognitive impairment and arterial stiffness was detected in a larger cohort of hemodialysis patients. Concerning the underlying pathogenesis of cognitive impairment, current results revealed a potential involvement of arterial stiffness, which has to be further evaluated in future studies. © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

Measuring the linear and nonlinear elastic properties of brain tissue with shear waves and inverse analysis.

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Jiang, Yi; Li, Guoyang; Qian, Lin-Xue; Liang, Si; Destrade, Michel; Cao, Yanping

2015-10-01

We use supersonic shear wave imaging (SSI) technique to measure not only the linear but also the nonlinear elastic properties of brain matter. Here, we tested six porcine brains ex vivo and measured the velocities of the plane shear waves induced by acoustic radiation force at different states of pre-deformation when the ultrasonic probe is pushed into the soft tissue. We relied on an inverse method based on the theory governing the propagation of small-amplitude acoustic waves in deformed solids to interpret the experimental data. We found that, depending on the subjects, the resulting initial shear modulus [Formula: see text] varies from 1.8 to 3.2 kPa, the stiffening parameter [Formula: see text] of the hyperelastic Demiray-Fung model from 0.13 to 0.73, and the third- [Formula: see text] and fourth-order [Formula: see text] constants of weakly nonlinear elasticity from [Formula: see text]1.3 to [Formula: see text]20.6 kPa and from 3.1 to 8.7 kPa, respectively. Paired [Formula: see text] test performed on the experimental results of the left and right lobes of the brain shows no significant difference. These values are in line with those reported in the literature on brain tissue, indicating that the SSI method, combined to the inverse analysis, is an efficient and powerful tool for the mechanical characterization of brain tissue, which is of great importance for computer simulation of traumatic brain injury and virtual neurosurgery.

Low Frequency Waves Detected in a Large Wave Flume under Irregular Waves with Different Grouping Factor and Combination of Regular Waves

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Luigia Riefolo

2018-02-01

Full Text Available This paper describes a set of experiments undertaken at Universitat Politècnica de Catalunya in the large wave flume of the Maritime Engineering Laboratory. The purpose of this study is to highlight the effects of wave grouping and long-wave short-wave combinations regimes on low frequency generations. An eigen-value decomposition has been performed to discriminate low frequencies. In particular, measured eigen modes, determined through the spectral analysis, have been compared with calculated modes by means of eigen analysis. The low frequencies detection appears to confirm the dependence on groupiness of the modal amplitudes generated in the wave flume. Some evidence of the influence of low frequency waves on runup and transport patterns are shown. In particular, the generation and evolution of secondary bedforms are consistent with energy transferred between the standing wave modes.

Analysis of human skin tissue by millimeter-wave reflectometry

NARCIS (Netherlands)

Smulders, P.F.M.

2013-01-01

Background/pupose: Millimeter-wave reflectometry is a potentially interesting technique to analyze the human skin in vivo in order to determine the water content locally in the skin. Purpose of this work is to investigate the possibility of skin-tissue differentiation. In addition, it addresses the

Fractional Calculus-Based Modeling of Electromagnetic Field Propagation in Arbitrary Biological Tissue

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Pietro Bia

2016-01-01

Full Text Available The interaction of electromagnetic fields and biological tissues has become a topic of increasing interest for new research activities in bioelectrics, a new interdisciplinary field combining knowledge of electromagnetic theory, modeling, and simulations, physics, material science, cell biology, and medicine. In particular, the feasibility of pulsed electromagnetic fields in RF and mm-wave frequency range has been investigated with the objective to discover new noninvasive techniques in healthcare. The aim of this contribution is to illustrate a novel Finite-Difference Time-Domain (FDTD scheme for simulating electromagnetic pulse propagation in arbitrary dispersive biological media. The proposed method is based on the fractional calculus theory and a general series expansion of the permittivity function. The spatial dispersion effects are taken into account, too. The resulting formulation is explicit, it has a second-order accuracy, and the need for additional storage variables is minimal. The comparison between simulation results and those evaluated by using an analytical method based on the Fourier transformation demonstrates the accuracy and effectiveness of the developed FDTD model. Five numerical examples showing the plane wave propagation in a variety of dispersive media are examined.

Nonlinear radiation of waves at combination frequencies due to radiation-surface wave interaction in plasmas

International Nuclear Information System (INIS)

El Naggar, I.A.; Hussein, A.M.; Khalil, Sh.M.

1992-09-01

Electromagnetic waves radiated with combination frequencies from a semi-bounded plasma due to nonlinear interaction of radiation with surface wave (both of P-polarization) has been investigated. Waves are radiated both into vacuum and plasma are found to be P-polarized. We take into consideration the continuity at the plasma boundary of the tangential components of the electric field of the waves. The case of normal incidence of radiation and rarefield plasma layer is also studied. (author). 7 refs

Pulsed-wave tissue Doppler imaging of the myocardium of cats with induced thyrotoxicosis Doppler tecidual pulsado do miocárdio de gatos com tirotoxicose induzida

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Daniel Capucho de Oliveira

2011-06-01

Full Text Available Left ventricular myocardial motion was quantified using pulsed-wave tissue Doppler imaging (PW-TDI in nine adult cats before and after thyrotoxicosis induction. In order to induce thyrotoxicosis, all cats were given 150µg kg-1 of levothyroxine sodium as a single oral dose each day for 10 weeks. PW-TDI examinations were performed immediately before the induction and by the end of the experimental protocol. An increase in myocardial motion velocity was documented at the interventricular septum level, demonstrated by an elevation in systolic (Sa, and early (Ea and late (Aa diastolic waves (PA velocidade de movimentação miocárdica do ventrículo esquerdo foi quantificada por meio de exames ecocardiográficos com Doppler tecidual pulsado (PW-TDI em nove gatos adultos antes e após indução à tirotoxicose. Para indução da tirotoxicose, todos os gatos receberam doses diárias de 150mg kg-1 de levotiroxina sódica, por via oral, durante 10 semanas. Os exames de PW-TDI foram realizados imediatamente antes da indução e ao final do protocolo experimental. Uma elevação na velocidade de movimentação miocárdica foi documentada ao nível do septo interventricular, demonstrado por um aumento das ondas sistólica (Sa e diastólicas (Ea e Aa; P<0,05. No entanto, nenhuma alteração nos valores de Sa, Ea e Aa foi encontrada ao nível da parede livre do ventrículo esquerdo. A frequência cardíaca aumentou significativamente entre os momentos experimentais, sendo que três animais apresentaram fusão das ondas Aa e Ea ao final do experimento. O protocolo experimental utilizado neste estudo causou alterações na velocidade de movimentação do miocárdio ventricular esquerdo, mas sem causar danos à função diastólica do ventrículo esquerdo.

Correlation of pulse wave velocity with left ventricular mass in patients with hypertension once blood pressure has been normalized

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Siu H. Chan

2012-02-01

Full Text Available Vascular stiffness has been proposed as a simple method to assess arterial loading conditions of the heart which induce left ventricular hypertrophy (LVH. There is some controversy as to whether the relationship of vascular stiffness to LVH is independent of blood pressure, and which measurement of arterial stiffness, augmentation index (AI or pulse wave velocity (PWV is best. Carotid pulse wave contor and pulse wave velocity of patients (n=20 with hypertension whose blood pressure (BP was under control (<140/90 mmHg with antihypertensive drug treatment medications, and without valvular heart disease, were measured. Left ventricular mass, calculated from 2D echocardiogram, was adjusted for body size using two different methods: body surface area and height. There was a significant (P<0.05 linear correlation between LV mass index and pulse wave velocity. This was not explained by BP level or lower LV mass in women, as there was no significant difference in PWV according to gender (1140.1+67.8 vs 1110.6+57.7 cm/s. In contrast to PWV, there was no significant correlation between LV mass and AI. In summary, these data suggest that aortic vascular stiffness is an indicator of LV mass even when blood pressure is controlled to less than 140/90 mmHg in hypertensive patients. The data further suggest that PWV is a better proxy or surrogate marker for LV mass than AI and the measurement of PWV may be useful as a rapid and less expensive assessment of the presence of LVH in this patient population.

Biological effect of pulsed dose rate brachytherapy with stepping sources if short half-times of repair are present in tissues

International Nuclear Information System (INIS)

Fowler, Jack F.; Limbergen, Erik F.M. van

1997-01-01

Purpose: To explore the possible increase of radiation effect in tissues irradiated by pulsed brachytherapy (PDR) for local tissue dose rates between those 'averaged over the whole pulse' and the instantaneous high dose rates close to the dwell positions. Increased effect is more likely for tissues with short half-times of repair of the order of a few minutes, similar to pulse durations. Methods and Materials: Calculations were done assuming the linear quadratic formula for radiation damage, in which only the dose-squared term is subject to exponential repair. The situation with two components of T (1(2)) is addressed. A constant overall time of 140 h and a constant total dose of 70 Gy were assumed throughout, the continuous low dose rate of 0.5 Gy/h (CLDR) providing the unitary standard effects for each PDR condition. Effects of dose rates ranging from 4 Gy/h to 120 Gy/h (HDR at 2 Gy/min) were studied, covering the gap in an earlier publication. Four schedules were examined: doses per pulse of 0.5, 1, 1.5, and 2 Gy given at repetition frequencies of 1, 2, 3, and 4 h, respectively, each with a range of assumed half-times of repair of 4 min to 1.5 h. Results are presented for late-responding tissues, the differences from CLDR being two or three times greater than for early-responding tissues and most tumors. Results: Curves are presented relating the ratio of increased biological effect (proportional to log cell kill) calculated for PDR relative to CLDR. Ratios as high as 1.5 can be found for large doses per pulse (2 Gy) if the half-time of repair in tissues is as short as a few minutes. The major influences on effect are dose per pulse, half-time of repair in tissue, and--when T (1(2)) is short--the instantaneous dose rate. Maximum ratios of PDR/CLDR occur when the dose rate is such that pulse duration is approximately equal to T (1(2)) . As dose rate in the pulse is increased, a plateau of effect is reached, for most T (1(2)) s, above 10 to 20 Gy/h, which is

Histological observation on dental hard tissue irradiated by ultrashort-pulsed laser

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Uchizono, Takeyuki; Awazu, Kunio; Igarashi, Akihiro; Kato, Junji; Hirai, Yoshito

2006-04-01

In the field of dentistry, effectiveness of USPL irradiation is researched because USPL has less thermal side effect to dental hard tissue. In this paper, we observed morphological change and optical change of dental hard tissue irradiated by USPL for discussing the safety and effectiveness of USPL irradiation to dental hard tissues. Irradiated samples were crown enamel and root dentin of bovine teeth. Lasers were Ti:sapphire laser, which had pulse duration (P d)of 130 fsec and pulse repetition rate (f) of 1kHz and wavelength (l) of 800nm, free electron laser (FEL), which had P d of 15 μsec and f of 10Hz and wavelength of 9.6μm, and Er:YAG laser, which had P d of 250 μsec and f of 10Hz and wavelength of 2.94μm. After laser irradiation, the sample surfaces and cross sections were examined with SEM and EDX. The optical change of samples was observed using FTIR. In SEM, the samples irradiated by USPL had sharp and accurate ablation with no crack and no carbonization. But, in FEL and Er:YAG laser, the samples has rough ablation with crack and carbonization. It was cleared that the P/Ca ratio of samples irradiated by USPL had same value as non-irradiated samples. There was no change in the IR absorption spectrum between samples irradiated by USPL and non-irradiated sample. But, they of samples irradiated by FEL and Er:YAG laser, however, had difference value as non-irradiated samples. These results showed that USPL might be effective to ablate dental hard tissue without thermal damage.

The effect of pulsed electric fields on carotenoids bioaccessibility: The role of tomato matrix.

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Bot, Francesca; Verkerk, Ruud; Mastwijk, Hennie; Anese, Monica; Fogliano, Vincenzo; Capuano, Edoardo

2018-02-01

Tomato fractions were subjected to pulsed electric fields treatment combined or not with heating. Results showed that pulsed electric fields and heating applied in combination or individually induced permeabilization of cell membranes in the tomato fractions. However, no changes in β-carotene and lycopene bioaccessibility were found upon combined and individual pulsed electric fields and heating, except in the following cases: (i) in tissue, a significant decrease in lycopene bioaccessibility upon combined pulsed electric fields and heating and heating only was observed; (ii) in chromoplasts, both β-carotene and lycopene bioaccessibility significantly decreased upon combined pulsed electric fields and heating and pulsed electric fields only. The reduction in carotenoids bioaccessibility was attributed to modification in chromoplasts membrane and carotenoids-protein complexes. Differences in the effects of pulsed electric fields on bioaccessibility among different tomato fractions were related to tomato structure complexity. Copyright © 2017 Elsevier Ltd. All rights reserved.

Compliance of the normal-sized aorta in adolescents with Marfan syndrome: comparison of MR measurements of aortic distensibility and pulse wave velocity

International Nuclear Information System (INIS)

Eichhorn, J.G.; Ruediger, H.J.; Gorenflo, M.; Khalil, M.; Ulmer, H.; Krissak, R.; Kauczor, H.U.; Ley, S.; Universitaetsklinik Heidelberg; Arnold, R.; Universitaetskinderklinik Freiburg; Boese, J.; Siemens AG, Medical Solutions, Forchheim; Krug, R.; Fink, C.

2007-01-01

Purpose: To compare the aortic compliance of the normal-sized aorta of adolescents with Marfan syndrome and healthy controls using MR measurements of the aortic distensibility and pulse wave velocity. Materials and Methods: Fourteen patients (median age: 15 [9-21] years) and 11 healthy subjects (23 [12-32] years) were examined at 1.5 T. The MR protocol included 2D steady-state free precession (SSFP)-CINE MRI of the aortic distensibility and PC-MRI of the pulse wave velocity. All measurements were positioned perpendicular to the descending aorta at the level of the diaphragm for assessing the changes in the aortic cross-sectional areas and additionally above and below this plane for assessing the pulse wave velocity. In addition contrast-enhanced 3D-MR angiography was performed in adolescents with Marfan syndrome to exclude morphologic changes and to prove normal-sized aorta. Results: Compared with control subjects, adolescents with Marfan syndrome had significantly decreased distensibility and significantly increased pulse wave velocity (χ 2 -test, p = 0.0002) using an age-related non-linear regression analysis. The related aortic compliance was significantly decreased (χ 2 -test, p = 0.0002). There was a good correlation between the two methods (r = 0.86). A low intraobserver variability was found for both methods (≤ 2 %). (orig.)

Correlations between ultrasonic pulse wave velocities and rock properties of quartz-mica schist

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Bharti Chawre

2018-06-01

Full Text Available Physico-mechanical properties are critically important parameters for rocks. This study aims to examine some of the rock properties of quartz-mica schist (QMS rocks in a cost-effective manner by establishing correlations between non-destructive and destructive tests. Using simple regression analysis, good correlations were obtained between the pulse wave velocities and the properties of QMS rocks. The results were further improved by using multiple regression analysis as compared to those obtained by the simple linear regression analysis. The results were also compared to the ones obtained by other empirical equations available. The general equations encompassing all types of rocks did not give reliable results of rock properties and showed large relative errors, ranging from 23% to 1146%. It is suggested that empirical correlations must be investigated separately for different types of rocks. The general empirical equations should not be used for the design and planning purposes before they are verified at least on one rock sample from the project site, as they may contain large unacceptable errors. Keywords: Pulse wave velocity, Physico-mechanical properties, Quartz-mica schist (QMS rocks, Non-destructive methods, Static elastic constants, Dynamic elastic constants

Acute effects of interval versus continuous endurance training on pulse wave reflection in healthy young men.

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Hanssen, Henner; Nussbaumer, Monique; Moor, Christoph; Cordes, Mareike; Schindler, Christian; Schmidt-Trucksäss, Arno

2015-02-01

Our aim was to investigate the acute and 24-hour (h) effects of high-intensity interval training (HIIT) and moderate continuous training (MCT) on arterial pulse wave reflection, an established marker of arterial stiffness and cardiovascular risk. In a randomized cross-over design, 21 young healthy male participants performed a HIIT or a MCT on separate visits. Before and 5 (t5), 20 (t20), 35 (t35), and 50 (t50) minutes after the acute exercise bouts, the crude augmentation index (AIx) and the AIx at a set heart rate (AIx@75) were analysed by applanation tonometry. Starting 1 h post-exercise, both indices were captured over 24-h with an oscillometric monitoring device. AIx did not change significantly after MCT but declined progressively after HIIT, reaching significantly lower values compared to MCT at t35 (P = 0.045) and t50 (P = 0.008). AIx@75 increased after both acute exercise types but was higher after HIIT at t5 (P HIIT (P = 0.007) but not after MCT (P = 0.813). Exercise intensity affects pulse wave reflection, with different time courses for AIx and AIx@75 post-exercise. Although initially higher after HIIT, AIx@75 declines in the 24-h recovery period indicating more favourable effects on pulse wave reflection compared to MCT. This may result in substantial positive chronic training effects on arterial stiffness in health and cardiovascular disease. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Electro-mechanical dynamics of spiral waves in a discrete 2D model of human atrial tissue.

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Paul Brocklehurst

Full Text Available We investigate the effect of mechano-electrical feedback and atrial fibrillation induced electrical remodelling (AFER of cellular ion channel properties on the dynamics of spiral waves in a discrete 2D model of human atrial tissue. The tissue electro-mechanics are modelled using the discrete element method (DEM. Millions of bonded DEM particles form a network of coupled atrial cells representing 2D cardiac tissue, allowing simulations of the dynamic behaviour of electrical excitation waves and mechanical contraction in the tissue. In the tissue model, each cell is modelled by nine particles, accounting for the features of individual cellular geometry; and discrete inter-cellular spatial arrangement of cells is also considered. The electro-mechanical model of a human atrial single-cell was constructed by strongly coupling the electrophysiological model of Colman et al. to the mechanical myofilament model of Rice et al., with parameters modified based on experimental data. A stretch-activated channel was incorporated into the model to simulate the mechano-electrical feedback. In order to investigate the effect of mechano-electrical feedback on the dynamics of spiral waves, simulations of spiral waves were conducted in both the electromechanical model and the electrical-only model in normal and AFER conditions, to allow direct comparison of the results between the models. Dynamics of spiral waves were characterized by tracing their tip trajectories, stability, excitation frequencies and meandering range of tip trajectories. It was shown that the developed DEM method provides a stable and efficient model of human atrial tissue with considerations of the intrinsically discrete and anisotropic properties of the atrial tissue, which are challenges to handle in traditional continuum mechanics models. This study provides mechanistic insights into the complex behaviours of spiral waves and the genesis of atrial fibrillation by showing an important role of

Electro-mechanical dynamics of spiral waves in a discrete 2D model of human atrial tissue.

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Brocklehurst, Paul; Ni, Haibo; Zhang, Henggui; Ye, Jianqiao

2017-01-01

We investigate the effect of mechano-electrical feedback and atrial fibrillation induced electrical remodelling (AFER) of cellular ion channel properties on the dynamics of spiral waves in a discrete 2D model of human atrial tissue. The tissue electro-mechanics are modelled using the discrete element method (DEM). Millions of bonded DEM particles form a network of coupled atrial cells representing 2D cardiac tissue, allowing simulations of the dynamic behaviour of electrical excitation waves and mechanical contraction in the tissue. In the tissue model, each cell is modelled by nine particles, accounting for the features of individual cellular geometry; and discrete inter-cellular spatial arrangement of cells is also considered. The electro-mechanical model of a human atrial single-cell was constructed by strongly coupling the electrophysiological model of Colman et al. to the mechanical myofilament model of Rice et al., with parameters modified based on experimental data. A stretch-activated channel was incorporated into the model to simulate the mechano-electrical feedback. In order to investigate the effect of mechano-electrical feedback on the dynamics of spiral waves, simulations of spiral waves were conducted in both the electromechanical model and the electrical-only model in normal and AFER conditions, to allow direct comparison of the results between the models. Dynamics of spiral waves were characterized by tracing their tip trajectories, stability, excitation frequencies and meandering range of tip trajectories. It was shown that the developed DEM method provides a stable and efficient model of human atrial tissue with considerations of the intrinsically discrete and anisotropic properties of the atrial tissue, which are challenges to handle in traditional continuum mechanics models. This study provides mechanistic insights into the complex behaviours of spiral waves and the genesis of atrial fibrillation by showing an important role of the mechano

Detection of leak-defective fuel rods using the circumferential Lamb waves excited by the resonance backscattering of ultrasonic pulses

International Nuclear Information System (INIS)

Choi, M.S.; Yang, M.S.; Kim, H.C.

1992-01-01

A new ultrasonic technique for detecting the infiltrated water in leaked fuel rods is developed. Propagation characteristics of the circumferential Lamb waves in the cladding tubes are estimated by the resonance scattering theory. The Lamb waves are excited by the resonance backscattering of ultrasonic pulses. In sound fuel rods, the existence of the Lamb waves is revealed by a series of periodic echoes. In leaked fuel rods, however, the Lamb waves are perturbed strongly by the scattered waves from the surface of fuel pellets, thus the periodic echoes are not observed. (author)

PASSIVE CAVITATION DETECTION DURING PULSED HIFU EXPOSURES OF EX VIVO TISSUES AND IN VIVO MOUSE PANCREATIC TUMORS

Science.gov (United States)

Li, Tong; Chen, Hong; Khokhlova, Tatiana; Wang, Yak-Nam; Kreider, Wayne; He, Xuemei; Hwang, Joo Ha

2014-01-01

Pulsed high-intensity focused ultrasound (pHIFU) has been demonstrated to enhance vascular permeability, disrupt tumor barriers and enhance drug penetration into tumor tissue through acoustic cavitation. Monitoring of cavitation activity during pHIFU treatments and knowing the ultrasound pressure levels sufficient to reliably induce cavitation in a given tissue are therefore very important. Here, three metrics of cavitation activity induced by pHIFU and evaluated by confocal passive cavitation detection were introduced: cavitation probability, cavitation persistence and the level of the broadband acoustic emissions. These metrics were used to characterize cavitation activity in several ex vivo tissue types (bovine tongue and liver and porcine adipose tissue and kidney) and gel phantoms (polyacrylamide and agarose) at varying peak-rarefactional focal pressures (1–12 MPa) during the following pHIFU protocol: frequency 1.1 MHz, pulse duration 1 ms, pulse repetition frequency 1 Hz. To evaluate the relevance of the measurements in ex vivo tissue, cavitation metrics were also investigated and compared in the ex vivo and in vivo murine pancreatic tumors that develop spontaneously in transgenic KPC mice and closely recapitulate human disease in their morphology. The cavitation threshold, defined at 50 % cavitation probability, was found to vary broadly among the investigated tissues (within 2.5–10 MPa), depending mostly on the water-lipid ratio that characterizes the tissue composition. Cavitation persistence and the intensity of broadband emissions depended both on tissue structure and lipid concentration. Both the cavitation threshold and broadband noise emission level were similar between ex vivo and in vivo pancreatic tumor tissue. The largest difference between in vivo and ex vivo settings was found in the pattern of cavitation occurrence throughout pHIFU exposure: it was sporadic in vivo, but ex vivo it decreased rapidly and stopped over the first few pulses

Passive cavitation detection during pulsed HIFU exposures of ex vivo tissues and in vivo mouse pancreatic tumors.

Science.gov (United States)

Li, Tong; Chen, Hong; Khokhlova, Tatiana; Wang, Yak-Nam; Kreider, Wayne; He, Xuemei; Hwang, Joo Ha

2014-07-01

Pulsed high-intensity focused ultrasound (pHIFU) has been shown to enhance vascular permeability, disrupt tumor barriers and enhance drug penetration into tumor tissue through acoustic cavitation. Monitoring of cavitation activity during pHIFU treatments and knowing the ultrasound pressure levels sufficient to reliably induce cavitation in a given tissue are therefore very important. Here, three metrics of cavitation activity induced by pHIFU and evaluated by confocal passive cavitation detection were introduced: cavitation probability, cavitation persistence and the level of the broadband acoustic emissions. These metrics were used to characterize cavitation activity in several ex vivo tissue types (bovine tongue and liver and porcine adipose tissue and kidney) and gel phantoms (polyacrylamide and agarose) at varying peak-rare factional focal pressures (1-12 MPa) during the following pHIFU protocol: frequency 1.1 MHz, pulse duration 1 ms and pulse repetition frequency 1 Hz. To evaluate the relevance of the measurements in ex vivo tissue, cavitation metrics were also investigated and compared in the ex vivo and in vivo murine pancreatic tumors that develop spontaneously in transgenic KrasLSL.G12 D/+; p53 R172 H/+; PdxCretg/+ (KPC) mice and closely re-capitulate human disease in their morphology. The cavitation threshold, defined at 50% cavitation probability, was found to vary broadly among the investigated tissues (within 2.5-10 MPa), depending mostly on the water-lipid ratio that characterizes the tissue composition. Cavitation persistence and the intensity of broadband emissions depended both on tissue structure and lipid concentration. Both the cavitation threshold and broadband noise emission level were similar between ex vivo and in vivo pancreatic tumor tissue. The largest difference between in vivo and ex vivo settings was found in the pattern of cavitation occurrence throughout pHIFU exposure: it was sporadic in vivo, but it decreased rapidly and stopped

Spiral-wave dynamics in ionically realistic mathematical models for human ventricular tissue: the effects of periodic deformation.

Science.gov (United States)

Nayak, Alok R; Pandit, Rahul

2014-01-01

We carry out an extensive numerical study of the dynamics of spiral waves of electrical activation, in the presence of periodic deformation (PD) in two-dimensional simulation domains, in the biophysically realistic mathematical models of human ventricular tissue due to (a) ten-Tusscher and Panfilov (the TP06 model) and (b) ten-Tusscher, Noble, Noble, and Panfilov (the TNNP04 model). We first consider simulations in cable-type domains, in which we calculate the conduction velocity θ and the wavelength λ of a plane wave; we show that PD leads to a periodic, spatial modulation of θ and a temporally periodic modulation of λ; both these modulations depend on the amplitude and frequency of the PD. We then examine three types of initial conditions for both TP06 and TNNP04 models and show that the imposition of PD leads to a rich variety of spatiotemporal patterns in the transmembrane potential including states with a single rotating spiral (RS) wave, a spiral-turbulence (ST) state with a single meandering spiral, an ST state with multiple broken spirals, and a state SA in which all spirals are absorbed at the boundaries of our simulation domain. We find, for both TP06 and TNNP04 models, that spiral-wave dynamics depends sensitively on the amplitude and frequency of PD and the initial condition. We examine how these different types of spiral-wave states can be eliminated in the presence of PD by the application of low-amplitude pulses by square- and rectangular-mesh suppression techniques. We suggest specific experiments that can test the results of our simulations.

Spiral-Wave Dynamics in Ionically Realistic MathematicalModels for Human Ventricular Tissue: The Effects of PeriodicDeformation

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Alok Ranjan Nayak

2014-06-01

Full Text Available We carry out an extensive numerical study of the dynamics of spiral waves of electrical activation, in the presence of periodic deformation (PD in two-dimensional simulation domains, in the biophysically realistic mathematical models of human ventricular tissue due to (a ten-Tusscher and Panfilov (the TP06 model and (b ten-Tusscher, Noble, Noble, and Panfilov (theTNNP04 model. We first consider simulations in cable-type domains, in which we calculate the conduction velocity $CV$ andthe wavelength $lambda$ of a plane wave; we show that PD leads to a periodic, spatial modulation of $CV$ and a temporallyperiodic modulation of $lambda$; both these modulations depend on the amplitude and frequency of the PD. We then examine three types of initial conditions for both TP06 and TNNP04 models and show that the imposition of PD leads to a rich variety ofspatiotemporal patterns in the transmembrane potential including states with a single rotating spiral (RS wave, a spiral-turbulence (ST state with a single meandering spiral, an ST state with multiple broken spirals, and a state SA in which all spirals are absorbed at the boundaries of our simulation domain. We find, for both TP06 and TNNP04 models, that spiral-wave dynamics depends sensitively on the amplitude and frequency of PD and the initial condition. We examine how these different types of spiral-wave states can be eliminated in the presence of PD by the application of low-amplitude pulses on square and rectangular control meshes. We suggest specific experiments that can test the results of our simulations.

Electric field measurements in a nanosecond pulse discharge by picosecond CARS/4-wave mixing

Science.gov (United States)

Goldberg, Ben; Shkurenkov, Ivan; Adamovich, Igor; Lempert, Walter

2014-10-01

Time-resolved electric field measurements in hydrogen by picosecond CARS/4-wave mixing are presented. Measurements are carried out in a high voltage nanosecond pulse discharge in hydrogen in plane-to-plane geometry, at pressures of up to several hundred Torr, and with a time resolution of 0.2 ns. Absolute calibration of the diagnostics is done using a sub-breakdown high voltage pulse of 12 kV/cm. A diffuse discharge is obtained by applying a peak high voltage pulse of 40 kV/cm between the electrodes. It is found that breakdown occurs at a lower field, 15--20 kV/cm, after which the field in the plasma is reduced rapidly due to plasma self shielding The experimental results are compared with kinetic modeling calculations, showing good agreement between the measured and the predicted electric field.

Continuous wave terahertz reflection imaging of human colorectal tissue

Science.gov (United States)

Doradla, Pallavi; Alavi, Karim; Joseph, Cecil S.; Giles, Robert H.

2013-03-01

Continuous wave terahertz (THz) imaging has the potential to offer a safe, non-ionizing, and nondestructive medical imaging modality for delineating colorectal cancer. Fresh excisions of normal colon tissue were obtained from surgeries performed at the University of Massachusetts Medical School, Worcester. Reflection measurements of thick sections of colorectal tissues, mounted in an aluminum sample holder, were obtained for both fresh and formalin fixed tissues. The two-dimensional reflection images were acquired by using an optically pumped far-infrared molecular gas laser operating at 584 GHz with liquid Helium cooled silicon bolometer detector. Using polarizers in the experiment both co-polarized and cross-polarized remittance form the samples was collected. Analysis of the images showed the importance of understanding the effects of formalin fixation while determining reflectance level of tissue response. The resulting co- and cross-polarized images of both normal and formalin fixed tissues showed uniform terahertz response over the entire sample area. Initial measurements indicated a co-polarized reflectance of 16%, and a cross-polarized reflectance of 0.55% from fresh excisions of normal colonic tissues.

Pulsed TV holography measurement and digital reconstruction of compression acoustic wave fields: application to nondestructive testing of thick metallic samples

International Nuclear Information System (INIS)

Trillo, C; Doval, A F; Deán-Ben, X L; López-Vázquez, J C; Fernández, J L; Hernández-Montes, S

2011-01-01

This paper describes a technique that numerically reconstructs the complex acoustic amplitude (i.e. the acoustic amplitude and phase) of a compression acoustic wave in the interior volume of a specimen from a set of full-field optical measurements of the instantaneous displacement of the surface. The volume of a thick specimen is probed in transmission mode by short bursts of narrowband compression acoustic waves generated at one of its faces. The temporal evolution of the displacement field induced by the bursts emerging at the opposite surface is measured by pulsed digital holographic interferometry (pulsed TV holography). A spatio-temporal 3D Fourier transform processing of the measured data yields the complex acoustic amplitude at the plane of the surface as a sequence of 2D complex-valued maps. Finally, a numerical implementation of the Rayleigh–Sommerfeld diffraction formula is employed to reconstruct the complex acoustic amplitude at other planes in the interior volume of the specimen. The whole procedure can be regarded as a combination of optical digital holography and acoustical holography methods. The technique was successfully tested on aluminium specimens with and without an internal artificial defect and sample results are presented. In particular, information about the shape and position of the defect was retrieved in the experiment performed on the flawed specimen, which indicates the potential applicability of the technique for the nondestructive testing of materials

Combined Wave and Current Bottom Boundary Layers: A Review

Science.gov (United States)

2016-03-01

transport, (3) the process of wave transition in shallow water in the presence of strong alongshore currents, (4) the interaction between oblique...conducted in relatively deep water with bottom sediment comprised mostly of silt. One of the earlier studies for a wide shallow shelf was conducted off...wave asymmetry in combined flows and how this drives mass transport, (3) the process of wave transition in shallow water in the presence of strong

Pulsed-laser-activated impulse response encoder: Sensitive detection of surface elastic waves on biomimetic microsized gel spheres

Science.gov (United States)

Yasukuni, Ryohei; Fukushima, Ryosuke; Iino, Takanori; Hosokawa, Yoichiroh

2017-11-01

A femtosecond-laser-induced impulsive force was applied to microsized calcium alginate (CaAlg) gel spheres as an external force to excite elastic waves. To evaluate elasticity, atomic force microscopy (AFM) was applied to detect vibration propagation. The sphere size dependence of the vibration was well reproduced by finite element method (FEM) simulation for pressure waves and surface acoustic waves. The obtained results indicate that the pulsed-laser-activated impulse response encoder (PLAIRE) enables the sensitive detection of elasticities, not only on inside but also on the surface.

Supersonic transient magnetic resonance elastography for quantitative assessment of tissue elasticity.

Science.gov (United States)

Liu, Yu; Liu, Jingfei; Fite, Brett Z; Foiret, Josquin; Ilovitsh, Asaf; Leach, J Kent; Dumont, Erik; Caskey, Charles F; Ferrara, Katherine W

2017-05-21

Non-invasive, quantitative methods to assess the properties of biological tissues are needed for many therapeutic and tissue engineering applications. Magnetic resonance elastography (MRE) has historically relied on external vibration to generate periodic shear waves. In order to focally assess a biomaterial or to monitor the response to ablative therapy, the interrogation of a specific region of interest by a focused beam is desirable and transient MRE (t-MRE) techniques have previously been developed to accomplish this goal. Also, strategies employing a series of discrete ultrasound pulses directed to increasing depths along a single line-of-sight have been designed to generate a quasi-planar shear wave. Such 'supersonic' excitations have been applied for ultrasound elasticity measurements. The resulting shear wave is higher in amplitude than that generated from a single excitation and the properties of the media are simply visualized and quantified due to the quasi-planar wave geometry and the opportunity to generate the wave at the site of interest. Here for the first time, we extend the application of supersonic methods by developing a protocol for supersonic transient magnetic resonance elastography (sst-MRE) using an MR-guided focused ultrasound system capable of therapeutic ablation. We apply the new protocol to quantify tissue elasticity in vitro using biologically-relevant inclusions and tissue-mimicking phantoms, compare the results with elasticity maps acquired with ultrasound shear wave elasticity imaging (US-SWEI), and validate both methods with mechanical testing. We found that a modified time-of-flight (TOF) method efficiently quantified shear modulus from sst-MRE data, and both the TOF and local inversion methods result in similar maps based on US-SWEI. With a three-pulse excitation, the proposed sst-MRE protocol was capable of visualizing quasi-planar shear waves propagating away from the excitation location and detecting differences in shear

Supersonic transient magnetic resonance elastography for quantitative assessment of tissue elasticity

Science.gov (United States)

Liu, Yu; Liu, Jingfei; Fite, Brett Z.; Foiret, Josquin; Ilovitsh, Asaf; Leach, J. Kent; Dumont, Erik; Caskey, Charles F.; Ferrara, Katherine W.

2017-05-01

Non-invasive, quantitative methods to assess the properties of biological tissues are needed for many therapeutic and tissue engineering applications. Magnetic resonance elastography (MRE) has historically relied on external vibration to generate periodic shear waves. In order to focally assess a biomaterial or to monitor the response to ablative therapy, the interrogation of a specific region of interest by a focused beam is desirable and transient MRE (t-MRE) techniques have previously been developed to accomplish this goal. Also, strategies employing a series of discrete ultrasound pulses directed to increasing depths along a single line-of-sight have been designed to generate a quasi-planar shear wave. Such ‘supersonic’ excitations have been applied for ultrasound elasticity measurements. The resulting shear wave is higher in amplitude than that generated from a single excitation and the properties of the media are simply visualized and quantified due to the quasi-planar wave geometry and the opportunity to generate the wave at the site of interest. Here for the first time, we extend the application of supersonic methods by developing a protocol for supersonic transient magnetic resonance elastography (sst-MRE) using an MR-guided focused ultrasound system capable of therapeutic ablation. We apply the new protocol to quantify tissue elasticity in vitro using biologically-relevant inclusions and tissue-mimicking phantoms, compare the results with elasticity maps acquired with ultrasound shear wave elasticity imaging (US-SWEI), and validate both methods with mechanical testing. We found that a modified time-of-flight (TOF) method efficiently quantified shear modulus from sst-MRE data, and both the TOF and local inversion methods result in similar maps based on US-SWEI. With a three-pulse excitation, the proposed sst-MRE protocol was capable of visualizing quasi-planar shear waves propagating away from the excitation location and detecting differences in shear

Pulse Wave Velocity Measuring System using Virtual Instrumentation on Mobile Device

Directory of Open Access Journals (Sweden)

Razvan Alin Ciobotariu

2013-03-01

Full Text Available Virtual instrumentation is a concept that permits customizable modular software measurement and the development of the user-defined tools for control, process and visualization of data, creating versatile systems, using modular programming, intuitive and easy to use. In this paper we investigate a possibility of using virtual instrumentation in the development of two physiological parameters monitoring system, in order to assess a cardiovascular parameter, the Pulse Wave Velocity (PWV. We choose to monitor this parameter due to major incidence and impact of cardiovascular diseases (CVD.

Picked FEL Micro Pulse for Nano-Second Interaction with Bio-Molecule

CERN Document Server

Suzuki, Sachiko; Ishii, Katsonuri; Kanai, T; Naito, Y

2004-01-01

Laser pulse duration is a very important parameter to determine the threshold between thermal and nonthermal effects in laser surgery of biomedical tissue. Free Electron Laser (FEL) at Osaka University, Japan, has a pulse structure in which a macropulse (pulse width : 15μs) consists of equally separated micropulses, whose width and interval are ~5ps and 44.8ns, respectively. Precise control of micropulse train may establish fast optic processes because thermal relaxation time in the tissue is about 1us. A pulse-picking system was designed in order to extract single or a few micropulses from an entire macropulse using an acousto-optic modulator (AOM) in which the light path can be temporally diffracted by an external gate signal. An extracted micropulse train was monitored by a mercury-cadmium-telluride (MCT) photodetector with ~1ns response time and recorded on digital oscilloscope. A single micropulse was extracted as a result of adjusting duration of the RF wave to 50 ns which is nearly equal to the ...

Four-Wave Mixing of Gigawatt Power, Long-Wave Infrared Radiation in Gases and Semiconductors

Science.gov (United States)

Pigeon, Jeremy James

The nonlinear optics of gigawatt power, 10 microm, 3 and 200 ps long pulses propagating in gases and semiconductors has been studied experimentally and numerically. In this work, the development of a high-repetition rate, picosecond, CO2 laser system has enabled experiments using peak intensities in the range of 1-10 GW/cm2, approximately one thousand times greater than previous nonlinear optics experiments in the long-wave infrared (LWIR) spectral region. The first measurements of the nonlinear refractive index of the atomic and molecular gases Kr, Xe, N2, O2 and the air at a wavelength near 10 microm were accomplished by studying the four-wave mixing (FWM) of dual-wavelength, 200 ps CO2 laser pulses. These measurements indicate that the nonlinearities of the diatomic molecules N2, O2 and the air are dominated by the molecular contribution to the nonlinear refractive index. Supercontinuum (SC) generation covering the infrared spectral range, from 2-20 microm, was realized by propagating 3 ps, 10 microm pulses in an approximately 7 cm long, Cr-doped GaAs crystal. Temporal measurements of the SC radiation show that pulse splitting accompanies the generation of such broadband light in GaAs. The propagation of 3 ps, 10 microm pulses in GaAs was studied numerically by solving the Generalized Nonlinear Schrodinger Equation (GNLSE). These simulations, combined with analytic estimates, were used to determine that stimulated Raman scattering combined with a modulational instability caused by the propagation of intense LWIR radiation in the negative group velocity dispersion region of GaAs are responsible for the SC generation process. The multiple FWM of a 106 GHz, 200 ps CO2 laser beat-wave propagating in GaAs was used to generate a broadband FWM spectrum that was compressed by the negative group velocity dispersion of GaAs and NaCl crystals to form trains of high-power, picosecond pulses at a wavelength near 10 microm. Experimental FWM spectra obtained using 165 and 882

Influence of length of interval between pulses in PDR brachytherapy (PDRBT on value of Biologically Equivalent Dose (BED in healthy tissues

Directory of Open Access Journals (Sweden)

Tomasz Piotrowski

2010-07-01

Full Text Available Purpose: Different PDR treatment schemas are used in clinical practice, however optimal length of interval between pulses still remains unclear. The aim of this work was to compare value of BED doses measured in surrounded healthy tissues according to different intervals between pulses in PDRBT. Influence of doses optimization on BED values was analyzed.Material and methods: Fifty-one patients treated in Greater Poland Cancer Centre were qualified for calculations.Calculations of doses were made in 51 patients with head and neck cancer, brain tumor, breast cancer, sarcoma, penis cancer and rectal cancer. Doses were calculated with the use of PLATO planning system in chosen critical points in surrounded healthy tissues. For all treatment plans the doses were compared using Biologically Equivalent Dose formula.Three interval lengths (1, 2 and 4 hours between pulses were chosen for calculations. For statistical analysis Friedman ANOVA test and Kendall ratio were used.Results: The median value of BED in chosen critical points in healthy tissues was statistically related to the length of interval between PDR pulses and decreased exponentially with 1 hour interval to 4 hours (Kendall = from 0.48 to 1.0; p = from 0.002 to 0.00001.Conclusions: Prolongation of intervals between pulses in PDR brachytherapy was connected with lower values of BED doses in healthy tissues. It seems that longer intervals between pulses reduced the risk of late complications, but also decreased the tumour control. Furthermore, optimization influenced the increase of doses in healthy tissues.

Simulation of laser-tattoo pigment interaction in a tissue-mimicking phantom using Q-switched and long-pulsed lasers.

Science.gov (United States)

Ahn, K J; Kim, B J; Cho, S B

2017-08-01

Laser therapy is the treatment of choice in tattoo removal. However, the precise mechanisms of laser-tattoo pigment interactions remain to be evaluated. We evaluated the geometric patterns of laser-tattoo pigment particle interactions using a tattoo pigment-embedded tissue-mimicking (TM) phantom. A Q-switched (QS) neodymium-doped yttrium aluminum garnet laser was used at settings of 532-, 660-, and 1064-nm wavelengths, single-pulse and quick pulse-to-pulse treatment modes, and spot sizes of 4 and 7 mm. Most of the laser-tattoo interactions in the experimental conditions formed cocoon-shaped or oval photothermal and photoacoustic injury zones, which contained fragmented tattoo particles in various sizes depending on the conditions. In addition, a long-pulsed 755-nm alexandrite laser was used at a spot size of 6 mm and pulse widths of 3, 5, and 10 ms. The finer granular pattern of tattoo destruction was observed in TM phantoms treated with 3- and 5-ms pulse durations compared to those treated with a 10-ms pulse. We outlined various patterns of laser-tattoo pigment interactions in a tattoo-embedded TM phantom to predict macroscopic tattoo and surrounding tissue reactions after laser treatment for tattoo removal. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Identifying coronary artery disease in asymptomatic middle-aged sportsmen : The additional value of pulse wave velocity

NARCIS (Netherlands)

Braber, Thijs L.; Prakken, Niek H J; Mosterd, Arend; Mali, Willem P Th M; Doevendans, Pieter A F M; Bots, Michiel L.; Velthuis, Birgitta K.

2015-01-01

Background: Cardiovascular screening may benefit middle-aged sportsmen, as coronary artery disease (CAD) is the main cause of exercise-related sudden cardiac death. Arterial stiffness, as measured by pulse wave velocity (PWV), may help identify sportsmen with subclinical CAD. We examined the

Renal tissue damage induced by focused shock waves

Science.gov (United States)

Ioritani, N.; Kuwahara, M.; Kambe, K.; Taguchi, K.; Saitoh, T.; Shirai, S.; Orikasa, S.; Takayama, K.; Lush, P. A.

1990-07-01

Biological evidence of renal arterial wall damage induced by the microjet due to shock wave-cavitation bubble interaction was demonstrated in living dog kidneys. We also intended to clarify the mechanism of renal tissue damage and the effects of different conditions of shock wave exposure (peak pressure of focused area, number of shots, exposure rate) on the renal tissue damage in comparison to stone disintegration. Disruption of arterial wall was the most remarkable histological change in the focused area of the kidneys. This lesion appeared as if the wall had been punctured by a needle. Large hematoma formation in the renal parenchym, and interstitial hemorrhage seemed to be the results of the arterial lesion. This arterial disorder also led to ischemic necrosis of the tubules surrounding the hematoma. Micro-angiographic examination of extracted kidneys also proved such arterial puncture lesions and ischemic lesions. The number of shots required for model stone disintegration was not inversely proportional to peak pressure. It decreased markedly when peak pressure was above 700 bar. Similarly thenumber of shots for hematoma formation was not inversely proportional to peak pressure, however, this decreased markedly above 500 bar. These results suggested that a hematoma could be formed under a lower peak pressure than that required for stone disintegration.

Resonant parametric interference effect in spontaneous bremsstrahlung of an electron in the field of a nucleus and two pulsed laser waves

Science.gov (United States)

Lebed', A. A.; Padusenko, E. A.; Roshchupkin, S. P.; Dubov, V. V.

2018-04-01

Electron-nucleus bremsstrahlung in the field of two moderately strong pulsed laser waves in the case of incommensurate frequencies is theoretically studied under resonant conditions. The process is studied in detail in a special kinematic region, where stimulated processes with correlated emission and absorption of photons of the first and second waves become predominant (parametric interference effect). The availability of this region is caused by interference of the first and second laser waves. The correspondence between the emission angle and the final-electron energy is established in this interference kinematic. In this case, the cross-sectional properties are determined by the multiphoton quantum interference parameter, which is proportional to the product of intensities of the first and second waves. The resonant differential cross section of electron-nucleus spontaneous bremsstrahlung with simultaneous registration of both emission angles of the spontaneous photon and the scattered electron can exceed by four or five orders of magnitude the corresponding cross section in the absence of an external field. It was shown for nonrelativistic electrons that the resonant cross section of the studied process in the field of two pulsed laser waves within the interference region in two order of magnitude may exceed corresponding cross sections at other scattering kinematics. The obtained results may be experimentally verified, for example, by scientific facilities at sources of pulsed laser radiation (such as SLAC, FAIR, XFEL, ELI).

Ultrasound Shear Wave Simulation of Breast Tumor Using Nonlinear Tissue Elasticity

Directory of Open Access Journals (Sweden)

Dae Woo Park

2016-01-01

Full Text Available Shear wave elasticity imaging (SWEI can assess the elasticity of tissues, but the shear modulus estimated in SWEI is often less sensitive to a subtle change of the stiffness that produces only small mechanical contrast to the background tissues. Because most soft tissues exhibit mechanical nonlinearity that differs in tissue types, mechanical contrast can be enhanced if the tissues are compressed. In this study, a finite element- (FE- based simulation was performed for a breast tissue model, which consists of a circular (D: 10 mm, hard tumor and surrounding tissue (soft. The SWEI was performed with 0% to 30% compression of the breast tissue model. The shear modulus of the tumor exhibited noticeably high nonlinearity compared to soft background tissue above 10% overall applied compression. As a result, the elastic modulus contrast of the tumor to the surrounding tissue was increased from 0.46 at 0% compression to 1.45 at 30% compression.

Ultrasound Shear Wave Simulation of Breast Tumor Using Nonlinear Tissue Elasticity.

Science.gov (United States)

Park, Dae Woo

2015-01-01

Shear wave elasticity imaging (SWEI) can assess the elasticity of tissues, but the shear modulus estimated in SWEI is often less sensitive to a subtle change of the stiffness that produces only small mechanical contrast to the background tissues. Because most soft tissues exhibit mechanical nonlinearity that differs in tissue types, mechanical contrast can be enhanced if the tissues are compressed. In this study, a finite element- (FE-) based simulation was performed for a breast tissue model, which consists of a circular (D: 10 mm, hard) tumor and surrounding tissue (soft). The SWEI was performed with 0% to 30% compression of the breast tissue model. The shear modulus of the tumor exhibited noticeably high nonlinearity compared to soft background tissue above 10% overall applied compression. As a result, the elastic modulus contrast of the tumor to the surrounding tissue was increased from 0.46 at 0% compression to 1.45 at 30% compression.

Influence of low-intensity pulsed ultrasound on osteogenic tissue regeneration in a periodontal injury model: X-ray image alterations assessed by micro-computed tomography.

Science.gov (United States)

Wang, Yunji; Chai, Zhaowu; Zhang, Yuanyuan; Deng, Feng; Wang, Zhibiao; Song, Jinlin

2014-08-01

This study was conducted to evaluate, with micro-computed tomography, the influence of low-intensity pulsed ultrasound on wound-healing in periodontal tissues. Periodontal disease with Class II furcation involvement was surgically produced at the bilateral mandibular premolars in 8 adult male beagle dogs. Twenty-four teeth were randomly assigned among 4 groups (G): G1, periodontal flap surgery; G2, periodontal flap surgery+low-intensity pulsed ultrasound (LIPUS); G3, guided tissue regeneration (GTR) surgery; G4, GTR surgery plus LIPUS. The affected area in the experimental group was exposed to LIPUS. At 6 and 8weeks, the X-ray images of regenerated teeth were referred to micro-CT scanning for 3-D measurement. Bone volume (BV), bone surface (BS), and number of trabeculae (Tb) in G2 and G4 were higher than in G1 and G3 (pperiodontal flap surgery group. LIPUS irradiation increased the number, volume, and area of new alveolar bone trabeculae. LIPUS has the potential to promote the repair of periodontal tissue, and may work effectively if combined with GTR. Copyright © 2014 Elsevier B.V. All rights reserved.

On Lamb and Rayleigh wave convergence in viscoelastic tissues

Energy Technology Data Exchange (ETDEWEB)

Nenadic, Ivan Z; Urban, Matthew W; Aristizabal, Sara; Mitchell, Scott A; Humphrey, Tye C; Greenleaf, James F, E-mail: Nenadic.Ivan@mayo.edu [Department of Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, 55905 (United States)

2011-10-21

Characterization of the viscoelastic material properties of soft tissue has become an important area of research over the last two decades. Our group has been investigating the feasibility of using a shear wave dispersion ultrasound vibrometry (SDUV) method to excite Lamb waves in organs with plate-like geometry to estimate the viscoelasticity of the medium of interest. The use of Lamb wave dispersion ultrasound vibrometry to quantify the mechanical properties of viscoelastic solids has previously been reported. Two organs, the heart wall and the spleen, can be readily modeled using plate-like geometries. The elasticity of these two organs is important because they change in pathological conditions. Diastolic dysfunction is the inability of the left ventricle (LV) of the heart to supply sufficient stroke volumes into the systemic circulation and is accompanied by the loss of compliance and stiffening of the LV myocardium. It has been shown that there is a correlation between high splenic stiffness in patients with chronic liver disease and strong correlation between spleen and liver stiffness. Here, we investigate the use of the SDUV method to quantify the viscoelasticity of the LV free-wall myocardium and spleen by exciting Rayleigh waves on the organ's surface and measuring the wave dispersion (change of wave velocity as a function of frequency) in the frequency range 40-500 Hz. An equation for Rayleigh wave dispersion due to cylindrical excitation was derived by modeling the excised myocardium and spleen with a homogenous Voigt material plate immersed in a nonviscous fluid. Boundary conditions and wave potential functions were solved for the surface wave velocity. Analytical and experimental convergence between the Lamb and Rayleigh waves is reported in a finite element model of a plate in a fluid of similar density, gelatin plate and excised porcine spleen and left-ventricular free-wall myocardium.

Heat generation caused by ablation of dental hard tissues with an ultrashort pulse laser (USPL) system.

Science.gov (United States)

Braun, Andreas; Krillke, Raphael Franz; Frentzen, Matthias; Bourauel, Christoph; Stark, Helmut; Schelle, Florian

2015-02-01

Heat generation during the removal of dental hard tissues may lead to a temperature increase and cause painful sensations or damage dental tissues. The aim of this study was to assess heat generation in dental hard tissues following laser ablation using an ultrashort pulse laser (USPL) system. A total of 85 specimens of dental hard tissues were used, comprising 45 specimens of human dentine evaluating a thickness of 1, 2, and 3 mm (15 samples each) and 40 specimens of human enamel with a thickness of 1 and 2 mm (20 samples each). Ablation was performed with an Nd:YVO4 laser at 1,064 nm, a pulse duration of 9 ps, and a repetition rate of 500 kHz with an average output power of 6 W. Specimens were irradiated for 0.8 s. Employing a scanner system, rectangular cavities of 1-mm edge length were generated. A temperature sensor was placed at the back of the specimens, recording the temperature during the ablation process. All measurements were made employing a heat-conductive paste without any additional cooling or spray. Heat generation during laser ablation depended on the dental hard tissue (enamel or dentine) and the thickness of the respective tissue (p dental hard tissues, heat generation has to be considered. Especially during laser ablation next to pulpal tissues, painful sensations and potential thermal injury of pulp tissue might occur.

Terahertz pulse generation from metal nanoparticle ink

Science.gov (United States)

Kato, Kosaku; Takano, Keisuke; Tadokoro, Yuzuru; Phan, Thanh Nhat Khoa; Nakajima, Makoto

2016-11-01

Terahertz pulse generation from metallic nanostructures irradiated by femtosecond laser pulses is of interest because the conversion efficiency from laser pulses to terahertz waves is increased by the local field enhancement resulting from the plasmon oscillation. In this talk we present our recent study on terahertz generation from metal nanoparticle ink. We baked a silver nanoparticle ink spin-coated onto a glass coverslip in various temperatures. On the surface of the baked ink, bumpy nanostructures are spontaneously formed, and the average size of bumps depends on the baking temperature. These structures are expected to lead to local field enhancement and then large nonlinear polarizations on the surface. The baked ink was irradiated by the output of regeneratively amplified Ti:sapphire femtosecond laser at an incidence angle of 45°. Waveforms of generated terahertz pulses are detected by electro-optical sampling. The generation efficiency was high when the average diameter of bumps was around 100 nm, which is realized when the ink is baked in 205 to 235°C in our setup. One of our next research targets is terahertz wave generation from micro-patterned metallic nanoparticle ink. It is an advantage of the metal nanoparticle ink that by using inkjet printers one can fabricate various patterns with micrometer scales, in which terahertz waves have a resonance. Combination of microstructures made by a printer and nanostructure spontaneously formed in the baking process will provide us terahertz emitters with unique frequency characteristics.

Theory and experiment of Fourier-Bessel field calculation and tuning of a pulsed wave annular array

DEFF Research Database (Denmark)

Fox, Paul D.; Jiqi, Cheng; Jian-yu, Lu

2003-01-01

A one-dimensional (1D) Fourier-Bessel series method for computing and tuning (beamforming) the linear lossless field of flat pulsed wave annular arrays is developed and supported with both numerical simulation and experimental verification. The technique represents a new method for modeling and t...

Simulation study and guidelines to generate Laser-induced Surface Acoustic Waves for human skin feature detection

Science.gov (United States)

Li, Tingting; Fu, Xing; Chen, Kun; Dorantes-Gonzalez, Dante J.; Li, Yanning; Wu, Sen; Hu, Xiaotang

2015-12-01

Despite the seriously increasing number of people contracting skin cancer every year, limited attention has been given to the investigation of human skin tissues. To this regard, Laser-induced Surface Acoustic Wave (LSAW) technology, with its accurate, non-invasive and rapid testing characteristics, has recently shown promising results in biological and biomedical tissues. In order to improve the measurement accuracy and efficiency of detecting important features in highly opaque and soft surfaces such as human skin, this paper identifies the most important parameters of a pulse laser source, as well as provides practical guidelines to recommended proper ranges to generate Surface Acoustic Waves (SAWs) for characterization purposes. Considering that melanoma is a serious type of skin cancer, we conducted a finite element simulation-based research on the generation and propagation of surface waves in human skin containing a melanoma-like feature, determine best pulse laser parameter ranges of variation, simulation mesh size and time step, working bandwidth, and minimal size of detectable melanoma.

Traveling waves and conservation laws for highly nonlinear wave equations modeling Hertz chains

Science.gov (United States)

Przedborski, Michelle; Anco, Stephen C.

2017-09-01

A highly nonlinear, fourth-order wave equation that models the continuum theory of long wavelength pulses in weakly compressed, homogeneous, discrete chains with a general power-law contact interaction is studied. For this wave equation, all solitary wave solutions and all nonlinear periodic wave solutions, along with all conservation laws, are derived. The solutions are explicitly parameterized in terms of the asymptotic value of the wave amplitude in the case of solitary waves and the peak of the wave amplitude in the case of nonlinear periodic waves. All cases in which the solution expressions can be stated in an explicit analytic form using elementary functions are worked out. In these cases, explicit expressions for the total energy and total momentum for all solutions are obtained as well. The derivation of the solutions uses the conservation laws combined with an energy analysis argument to reduce the wave equation directly to a separable first-order differential equation that determines the wave amplitude in terms of the traveling wave variable. This method can be applied more generally to other highly nonlinear wave equations.

Two-photon stimulated emission and pulse amplification

International Nuclear Information System (INIS)

Yuen, H.P.

1975-01-01

Threshold conditions are given for the sustained operation of standing-wave and long-pulse traveling-wave two-photon lasers. Pulse shortening in long-pulse two-photon amplification, a behavior absent in the one-photon case, is also demonstrated analytically. (U.S.)

Interactions of Low-Frequency, Pulsed Electromagnetic Fields with Living Tissue: Biochemical Responses and Clinical Results

DEFF Research Database (Denmark)

Rahbek, Ulrik L.; Tritsaris, Katerina; Dissing, Steen

2005-01-01

In recent years many studies have demonstrated stimulatory effects of pulsed electromagnetic fields (PEMF) on biological tissue. However, controversies have also surrounded the research often due to the lack of knowledge of the different physical consequences of static versus pulsed electromagnetic......, are still lacking. Despite the apparent success of the PEMF technology very little is known regarding the coupling between pulsed electrical fields and biochemical events leading to cellular responses. Insight into this research area is therefore of great importance. In this review we describe the physical...... properties of PEMF-induced electrical fields and explain the typical set up for coils and pulse patterns. Furthermore, we discuss possible models that can account for mechanisms by which induced electric fields are able to enhance cellular signaling. We have emphasized the currently well-documented effects...

Numerical modeling of the pulse wave propagation in large blood vessels based on liquid and wall interaction

International Nuclear Information System (INIS)

Rup, K; Dróżdż, A

2014-01-01

The purpose of this article is to develop a non-linear, one-dimensional model of pulse wave propagation in the arterial cardiovascular system. The model includes partial differential equations resulting from the balance of mass and momentum for the fluid-filled area and the balance equation for the area of the wall and vessels. The considered mathematical model of pulse wave propagation in the thoracic aorta section takes into account the viscous dissipation of fluid energy, realistic values of parameters describing the physicochemical properties of blood and vessel wall. Boundary and initial conditions contain the appropriate information obtained from in vivo measurements. As a result of the numerical solution of the mass and momentum balance equations for the blood and the equilibrium equation for the arterial wall area, time- dependent deformation, respective velocity profiles and blood pressure were determined.

Generation of thermo-acoustic waves from pulsed solar/IR radiation

Science.gov (United States)

Rahman, Aowabin

Acoustic waves could potentially be used in a wide range of engineering applications; however, the high energy consumption in generating acoustic waves from electrical energy and the cost associated with the process limit the use of acoustic waves in industrial processes. Acoustic waves converted from solar radiation provide a feasible way of obtaining acoustic energy, without relying on conventional nonrenewable energy sources. One of the goals of this thesis project was to experimentally study the conversion of thermal to acoustic energy using pulsed radiation. The experiments were categorized into "indoor" and "outdoor" experiments, each with a separate experimental setup. The indoor experiments used an IR heater to power the thermo-acoustic lasers and were primarily aimed at studying the effect of various experimental parameters on the amplitude of sound waves in the low frequency range (below 130 Hz). The IR radiation was modulated externally using a chopper wheel and then impinged on a porous solid, which was housed inside a thermo-acoustic (TA) converter. A microphone located at a certain distance from the porous solid inside the TA converter detected the acoustic signals. The "outdoor" experiments, which were targeted at TA conversion at comparatively higher frequencies (in 200 Hz-3 kHz range) used solar energy to power the thermo-acoustic laser. The amplitudes (in RMS) of thermo-acoustic signals obtained in experiments using IR heater as radiation source were in the 80-100 dB range. The frequency of acoustic waves corresponded to the frequency of interceptions of the radiation beam by the chopper. The amplitudes of acoustic waves were influenced by several factors, including the chopping frequency, magnitude of radiation flux, type of porous material, length of porous material, external heating of the TA converter housing, location of microphone within the air column, and design of the TA converter. The time-dependent profile of the thermo-acoustic signals

EVOLUTION OF FAST MAGNETOACOUSTIC PULSES IN RANDOMLY STRUCTURED CORONAL PLASMAS

International Nuclear Information System (INIS)

Yuan, D.; Li, B.; Pascoe, D. J.; Nakariakov, V. M.; Keppens, R.

2015-01-01

We investigate the evolution of fast magnetoacoustic pulses in randomly structured plasmas, in the context of large-scale propagating waves in the solar atmosphere. We perform one-dimensional numerical simulations of fast wave pulses propagating perpendicular to a constant magnetic field in a low-β plasma with a random density profile across the field. Both linear and nonlinear regimes are considered. We study how the evolution of the pulse amplitude and width depends on their initial values and the parameters of the random structuring. Acting as a dispersive medium, a randomly structured plasma causes amplitude attenuation and width broadening of the fast wave pulses. After the passage of the main pulse, secondary propagating and standing fast waves appear. Width evolution of both linear and nonlinear pulses can be well approximated by linear functions; however, narrow pulses may have zero or negative broadening. This arises because narrow pulses are prone to splitting, while broad pulses usually deviate less from their initial Gaussian shape and form ripple structures on top of the main pulse. Linear pulses decay at an almost constant rate, while nonlinear pulses decay exponentially. A pulse interacts most efficiently with a random medium with a correlation length of about half of the initial pulse width. This detailed model of fast wave pulses propagating in highly structured media substantiates the interpretation of EIT waves as fast magnetoacoustic waves. Evolution of a fast pulse provides us with a novel method to diagnose the sub-resolution filamentation of the solar atmosphere

Hydrodynamic model for ultra-short pulse ablation of hard dental tissue

Energy Technology Data Exchange (ETDEWEB)

London, R.A.; Bailey, D.S.; Young, D.A.; Alley, W.E.; Feit, M.D.; Rubenchik, A.M. [Lawrence Livermore National Lab., CA (United States); Neev, J. [Beckman Laser Inst., Irvine, CA (United States)

1996-02-29

A computational model for the ablation of tooth enamel by ultra-short laser pulses is presented. The role of simulations using this model in designing and understanding laser drilling systems is discussed. Pulses of duration 300 fsec and intensity greater than 10{sup 12} W/cm{sup 2} are considered. Laser absorption proceeds via multi-photon initiated plasma mechanism. The hydrodynamic response is calculated with a finite difference method, using an equation of state constructed from thermodynamic functions including electronic, ion motion, and chemical binding terms. Results for the ablation efficiency are presented. An analytic model describing the ablation threshold and ablation depth is presented. Thermal coupling to the remaining tissue and long-time thermal conduction are calculated. Simulation results are compared to experimental measurements of the ablation efficiency. Desired improvements in the model are presented.

Synthesis of ultrawideband radiation of combined antenna arrays excited by nanosecond bipolar voltage pulses

International Nuclear Information System (INIS)

Koshelev, V I; Plisko, V V; Sevostyanov, E A

2017-01-01

To broaden the spectrum of high-power ultrawideband radiation, it is suggested to synthesize an electromagnetic pulse summing the pulses of different length in free space. On the example of model pulses corresponding to radiation of combined antennas excited by bipolar voltage pulses of the length of 2 and 3 ns, the possibility of twofold broadening of the radiation spectrum was demonstrated. Radiation pulses with the spectrum width exceeding three octaves were obtained. Pattern formation by the arrays of different geometry excited by the pulses having different time shifts was considered. Optimum array structure with the pattern maximum in the main direction was demonstrated on the example of a 2×2 array. (paper)

Energy scaling of terahertz-wave parametric sources.

Science.gov (United States)

Tang, Guanqi; Cong, Zhenhua; Qin, Zengguang; Zhang, Xingyu; Wang, Weitao; Wu, Dong; Li, Ning; Fu, Qiang; Lu, Qingming; Zhang, Shaojun

2015-02-23

Terahertz-wave parametric oscillators (TPOs) have advantages of room temperature operation, wide tunable range, narrow line-width, good coherence. They have also disadvantage of small pulse energy. In this paper, several factors preventing TPOs from generating high-energy THz pulses and the corresponding solutions are analyzed. A scheme to generate high-energy THz pulses by using the combination of a TPO and a Stokes-pulse-injected terahertz-wave parametric generator (spi-TPG) is proposed and demonstrated. A TPO is used as a source to generate a seed pulse for the surface-emitted spi-TPG. The time delay between the pump and Stokes pulses is adjusted to guarantee they have good temporal overlap. The pump pulses have a large pulse energy and a large beam size. The Stokes beam is enlarged to make its size be larger than the pump beam size to have a large effective interaction volume. The experimental results show that the generated THz pulse energy from the spi-TPG is 1.8 times as large as that obtained from the TPO for the same pumping pulse energy density of 0.90 J/cm(2) and the same pumping beam size of 3.0 mm. When the pumping beam sizes are 5.0 and 7.0 mm, the enhancement times are 3.7 and 7.5, respectively. The spi-TPG here is similar to a difference frequency generator; it can also be used as a Stokes pulse amplifier.

Evaluation of an optical fiber probe for in vivo measurement of the photoacoustic response of tissues

Science.gov (United States)

Beard, Paul C.; Mills, Timothy N.

1995-05-01

A miniature (1 mm diameter) all-optical photoacoustic probe for generating and detecting ultrasonic thermoelastic waves in biological media at the tip of an optical fiber has been developed. The probe provides a compact and convenient means of performing pulsed photoacoustic spectroscopy for the characterization of biological tissue. The device is based upon a transparent Fabry Perot polymer film ultrasound sensor mounted directly over the end of a multimode optical fiber. The optical fiber is used to deliver nanosecond laser pulses to the tissue producing thermoelastic waves which are then detected by the sensor. Detection sensitivities of 53 mv/MPa and a 10 kPa acoustic noise floor have been demonstrated giving excellent signal to noise ratios in a strong liquid absorber. Lower, but clearly detectable, signals in post mortem human aorta have also been observed. The performance and small physical size of the device suggest that it has the potential to perform remote in situ photoacoustic measurements in tissue.

Combining high power diode lasers using fiber bundles for beam delivery in optoacoustic endoscopy applications

Science.gov (United States)

Gawali, Sandeep Babu; Leggio, Luca; Sánchez, Miguel; Rodríguez, Sergio; Dadrasnia, Ehsan; Gallego, Daniel C.; Lamela, Horacio

2016-05-01

Optoacoustic (OA) effect refers to the generation of the acoustic waves due to absorption of light energy in a biological tissue. The incident laser pulse is absorbed by the tissue, resulting in the generation of ultrasound that is typically detected by a piezoelectric detector. Compared to other techniques, the advantage of OA imaging (OAI) technique consists in combining the high resolution of ultrasound technique with the high contrast of optical imaging. Generally, Nd:YAG and OPO systems are used for the generation of OA waves but their use in clinical environment is limited for many aspects. On the other hand, high-power diode lasers (HPDLs) emerge as potential alternative. However, the power of HPDLs is still relatively low compared to solid-state lasers. We show a side-by-side combination of several HPDLs in an optical fiber bundle to increase the amount of power for OA applications. Initially, we combine the output optical power of several HPDLs at 905 nm using two 7 to 1 round optical fiber bundles featuring a 675 μm and 1.2 mm bundle aperture. In a second step, we couple the output light of these fiber bundles to a 600 μm core diameter endoscopic fiber, reporting the corresponding coupling efficiencies. The fiber bundles with reasonable small diameter are likely to be used for providing sufficient light energy to potential OA endoscopy (OAE) applications.

Laser cutting of bone tissue under bulk water with a pulsed ps-laser at 532 nm.

Science.gov (United States)

Tulea, Cristian-Alexander; Caron, Jan; Gehlich, Nils; Lenenbach, Achim; Noll, Reinhard; Loosen, Peter

2015-10-01

Hard-tissue ablation was already investigated for a broad variety of pulsed laser systems, which cover almost the entire range of available wavelengths and pulse parameters. Most effective in hard-tissue ablation are Er:YAG and CO2 lasers, both utilizing the effect of absorption of infrared wavelengths by water and so-called explosive vaporization, when a thin water film or water–air spray is supplied. The typical flow rates and the water layer thicknesses are too low for surgical applications where bleeding occurs and wound flushing is necessary. We studied a 20 W ps-laser with 532 nm wavelength and a pulse energy of 1 mJ to effectively ablate bones that are submerged 14 mm under water. For these laser parameters, the plasma-mediated ablation mechanism is dominant. Simulations based on the blow-off model predict the cut depth and cross-sectional shape of the incision. The model is modified considering the cross section of the Gaussian beam, the incident angle, and reflections. The ablation rate amounts to 0.2  mm3/s, corresponding to an increase by at least 50% of the highest values published so far for ultrashort laser ablation of hard tissue.

Biological effects of laser-induced stress waves

International Nuclear Information System (INIS)

Doukas, A.; Lee, S.; McAuliffe, D.

1995-01-01

Laser-induced stress waves can be generated by one of the following mechanisms: Optical breakdown, ablation or rapid heating of an absorbing medium. These three modes of laser interaction with matter allow the investigation of cellular and tissue responses to stress waves with different characteristics and under different conditions. The most widely studied phenomena are those of the collateral damage seen in photodisruption in the eye and in 193 run ablation of cornea and skin. On the other hand, the therapeutic application of laser-induced stress waves has been limited to the disruption of noncellular material such as renal stones, atheromatous plaque and vitreous strands. The effects of stress waves to cells and tissues can be quite disparate. Stress waves can fracture tissue, damage cells, and increase the permeability of the plasma membrane. The viability of cell cultures exposed to stress waves increases with the peak stress and the number of pulses applied. The rise time of the stress wave also influences the degree of cell injury. In fact, cell viability, as measured by thymidine incorporation, correlates better with the stress gradient than peak stress. Recent studies have also established that stress waves induce a transient increase of the permeability of the plasma membrane in vitro. In addition, if the stress gradient is below the damage threshhold, the cells remain viable. Thus, stress waves can be useful as a means of drug delivery, increasing the intracellular drug concentration and allowing the use of drugs which are impermeable to the cell membrane. The present studies show that it is important to create controllable stress waves. The wavelength tunability and the micropulse structure of the free electron laser is ideal for generating stress waves with independently adjustable parameters, such as rise time, duration and peak stress

Scalable UWB photonic generator based on the combination of doublet pulses.

Science.gov (United States)

Moreno, Vanessa; Rius, Manuel; Mora, José; Muriel, Miguel A; Capmany, José

2014-06-30

We propose and experimentally demonstrate a scalable and reconfigurable optical scheme to generate high order UWB pulses. Firstly, various ultra wideband doublets are created through a process of phase-to-intensity conversion by means of a phase modulation and a dispersive media. In a second stage, doublets are combined in an optical processing unit that allows the reconfiguration of UWB high order pulses. Experimental results both in time and frequency domains are presented showing good performance related to the fractional bandwidth and spectral efficiency parameters.

Patterns of digital volume pulse waveform and pulse transit time in ...

African Journals Online (AJOL)

In this study the digital volume pulse wave and the pulse transit time of the thumb and big toe were analyzed in young and older subjects some of whom were hypertensive. We aimed to study the components and patterns of the pulse waveform and the pulse transit time and how they might change. Material and Methods: ...

SIMULATION OF FORWARD AND BACKWARD WAVES EVOLUTION OF FEW-CYCLE PULSES PROPAGATING IN AN OPTICAL WAVEGUIDE WITH DISPERSION AND CUBIC NONLINEARITY OF ELECTRONIC AND ELECTRONIC-VIBRATION NATURE

Directory of Open Access Journals (Sweden)

L. S. Konev

2015-09-01

Full Text Available Numerical method for calculation of forward and backward waves of intense few-cycle laser pulses propagating in an optical waveguide with dispersion and cubic nonlinearity of electronic and electronic-vibration nature is described. Simulations made with the implemented algorithm show that accounting for Raman nonlinearity does not lead to qualitative changes in behavior of the backward wave. Speaking about quantitative changes, the increase of efficiency of energy transfer from the forward wave to the backward wave is observed. Presented method can be also used to simulate interaction of counterpropagating pulses.

Tissue Harmonic Synthetic Aperture Imaging

DEFF Research Database (Denmark)

Rasmussen, Joachim

The main purpose of this PhD project is to develop an ultrasonic method for tissue harmonic synthetic aperture imaging. The motivation is to advance the field of synthetic aperture imaging in ultrasound, which has shown great potentials in the clinic. Suggestions for synthetic aperture tissue...... system complexity compared to conventional synthetic aperture techniques. In this project, SASB is sought combined with a pulse inversion technique for 2nd harmonic tissue harmonic imaging. The advantages in tissue harmonic imaging (THI) are expected to further improve the image quality of SASB...

Counter-propagating wave interaction for contrast-enhanced ultrasound imaging

Science.gov (United States)

Renaud, G.; Bosch, J. G.; ten Kate, G. L.; Shamdasani, V.; Entrekin, R.; de Jong, N.; van der Steen, A. F. W.

2012-11-01

Most techniques for contrast-enhanced ultrasound imaging require linear propagation to detect nonlinear scattering of contrast agent microbubbles. Waveform distortion due to nonlinear propagation impairs their ability to distinguish microbubbles from tissue. As a result, tissue can be misclassified as microbubbles, and contrast agent concentration can be overestimated; therefore, these artifacts can significantly impair the quality of medical diagnoses. Contrary to biological tissue, lipid-coated gas microbubbles used as a contrast agent allow the interaction of two acoustic waves propagating in opposite directions (counter-propagation). Based on that principle, we describe a strategy to detect microbubbles that is free from nonlinear propagation artifacts. In vitro images were acquired with an ultrasound scanner in a phantom of tissue-mimicking material with a cavity containing a contrast agent. Unlike the default mode of the scanner using amplitude modulation to detect microbubbles, the pulse sequence exploiting counter-propagating wave interaction creates no pseudoenhancement behind the cavity in the contrast image.

Counter-propagating wave interaction for contrast-enhanced ultrasound imaging

International Nuclear Information System (INIS)

Renaud, G; Bosch, J G; Ten Kate, G L; De Jong, N; Van der Steen, A F W; Shamdasani, V; Entrekin, R

2012-01-01

Most techniques for contrast-enhanced ultrasound imaging require linear propagation to detect nonlinear scattering of contrast agent microbubbles. Waveform distortion due to nonlinear propagation impairs their ability to distinguish microbubbles from tissue. As a result, tissue can be misclassified as microbubbles, and contrast agent concentration can be overestimated; therefore, these artifacts can significantly impair the quality of medical diagnoses. Contrary to biological tissue, lipid-coated gas microbubbles used as a contrast agent allow the interaction of two acoustic waves propagating in opposite directions (counter-propagation). Based on that principle, we describe a strategy to detect microbubbles that is free from nonlinear propagation artifacts. In vitro images were acquired with an ultrasound scanner in a phantom of tissue-mimicking material with a cavity containing a contrast agent. Unlike the default mode of the scanner using amplitude modulation to detect microbubbles, the pulse sequence exploiting counter-propagating wave interaction creates no pseudoenhancement behind the cavity in the contrast image. (fast track communication)

Pulse wave velocity and cognitive function in older adults.

Science.gov (United States)

Zhong, Wenjun; Cruickshanks, Karen J; Schubert, Carla R; Carlsson, Cynthia M; Chappell, Richard J; Klein, Barbara E K; Klein, Ronald; Acher, Charles W

2014-01-01

Arterial stiffness may be associated with cognitive function. In this study, pulse wave velocity (PWV) was measured from the carotid to femoral (CF-PWV) and from the carotid to radial (CR-PWV) with the Complior SP System. Cognitive function was measured by 6 tests of executive function, psychomotor speed, memory, and language fluency. A total of 1433 participants were included (mean age 75 y, 43% men). Adjusting for age, sex, education, pulse rate, hemoglobin A1C, high-density lipoprotein cholesterol, hypertension, cardiovascular disease history, smoking, drinking, and depression symptoms, a CF-PWV>12 m/s was associated with a lower Mini-Mental State Examination score (coefficient: -0.31, SE: 0.11, P=0.005), fewer words recalled on Auditory Verbal Learning Test (coefficient: -1.10, SE: 0.43, P=0.01), and lower score on the composite cognition score (coefficient: -0.10, SE: 0.05, P=0.04) and marginally significantly associated with longer time to complete Trail Making Test-part B (coefficient: 6.30, SE: 3.41, P=0.06), CF-PWV was not associated with Trail Making Test-part A, Digit Symbol Substation Test, or Verbal Fluency Test. No associations were found between CR-PWV and cognitive performance measures. Higher large artery stiffness was associated with worse cognitive function, and longitudinal studies are needed to confirm these associations.

A pulse coding and decoding strategy to perform Lamb wave inspections using simultaneously multiple actuators

Science.gov (United States)

De Marchi, Luca; Marzani, Alessandro; Moll, Jochen; Kudela, Paweł; Radzieński, Maciej; Ostachowicz, Wiesław

2017-07-01

The performance of Lamb wave based monitoring systems, both in terms of diagnosis time and data complexity, can be enhanced by increasing the number of transducers used to actuate simultaneously the guided waves in the inspected medium. However, in case of multiple simultaneously-operated actuators the interference among the excited wave modes within the acquired signals has to be considered for the further processing. To this aim, in this work a code division strategy based on the Warped Frequency Transform is presented. At first, the proposed procedure encodes actuation pulses using Gold sequences. Next, for each considered actuator the acquired signals are compensated from dispersion by cross correlating the warped version of the actuated and received signals. Compensated signals form the base for a final wavenumber imaging meant at emphasizing defects and or anomalies by removing incident wavefield and edge reflections. The proposed strategy is tested numerically, and validated through an experiment in which guided waves are actuated in a plate by four piezoelectric transducers operating simultaneously.

Irreversible electroporation ablation area enhanced by synergistic high- and low-voltage pulses.

Directory of Open Access Journals (Sweden)

Chenguo Yao

Full Text Available Irreversible electroporation (IRE produced by a pulsed electric field can ablate tissue. In this study, we achieved an enhancement in ablation area by using a combination of short high-voltage pulses (HVPs to create a large electroporated area and long low-voltage pulses (LVPs to ablate the electroporated area. The experiments were conducted in potato tuber slices. Slices were ablated with an array of four pairs of parallel steel electrodes using one of the following four electric pulse protocols: HVP, LVP, synergistic HVP+LVP (SHLVP or LVP+HVP. Our results showed that the SHLVPs more effectively necrotized tissue than either the HVPs or LVPs, even when the SHLVP dose was the same as or lower than the HVP or LVP doses. The HVP and LVP order mattered and only HVPs+LVPs (SHLVPs treatments increased the size of the ablation zone because the HVPs created a large electroporated area that was more susceptible to the subsequent LVPs. Real-time temperature change monitoring confirmed that the tissue was non-thermally ablated by the electric pulses. Theoretical calculations of the synergistic effects of the SHLVPs on tissue ablation were performed. Our proposed SHLVP protocol provides options for tissue ablation and may be applied to optimize the current clinical IRE protocols.

Irreversible electroporation ablation area enhanced by synergistic high- and low-voltage pulses.

Science.gov (United States)

Yao, Chenguo; Lv, Yanpeng; Dong, Shoulong; Zhao, Yajun; Liu, Hongmei

2017-01-01

Irreversible electroporation (IRE) produced by a pulsed electric field can ablate tissue. In this study, we achieved an enhancement in ablation area by using a combination of short high-voltage pulses (HVPs) to create a large electroporated area and long low-voltage pulses (LVPs) to ablate the electroporated area. The experiments were conducted in potato tuber slices. Slices were ablated with an array of four pairs of parallel steel electrodes using one of the following four electric pulse protocols: HVP, LVP, synergistic HVP+LVP (SHLVP) or LVP+HVP. Our results showed that the SHLVPs more effectively necrotized tissue than either the HVPs or LVPs, even when the SHLVP dose was the same as or lower than the HVP or LVP doses. The HVP and LVP order mattered and only HVPs+LVPs (SHLVPs) treatments increased the size of the ablation zone because the HVPs created a large electroporated area that was more susceptible to the subsequent LVPs. Real-time temperature change monitoring confirmed that the tissue was non-thermally ablated by the electric pulses. Theoretical calculations of the synergistic effects of the SHLVPs on tissue ablation were performed. Our proposed SHLVP protocol provides options for tissue ablation and may be applied to optimize the current clinical IRE protocols.

Modeling digital pulse waveforms by solving one-dimensional Navier-stokes equations.

Science.gov (United States)

Fedotov, Aleksandr A; Akulova, Anna S; Akulov, Sergey A

2016-08-01

Mathematical modeling for composition distal arterial pulse wave in the blood vessels of the upper limbs was considered. Formation of distal arterial pulse wave is represented as a composition of forward and reflected pulse waves propagating along the arterial vessels. The formal analogy between pulse waves propagation along the human arterial system and the propagation of electrical oscillations in electrical transmission lines with distributed parameters was proposed. Dependencies of pulse wave propagation along the human arterial system were obtained by solving the one-dimensional Navier-Stokes equations for a few special cases.

Holographic interferometric observation of shock wave focusing to extracorporeal shock wave lithotripsy

Science.gov (United States)

Takayama, Kazuyoshi; Obara, Tetsuro; Onodera, Osamu

1991-04-01

Underwater shock wave focusing is successfully applied to disintegrate and remove kidney stones or gallbladder stones without using surgical operations. This treatment is one of the most peaceful applications ofshock waves and is named as the Extracorporeal Shock Wave Lithotripsy. Ajoint research project is going on between the Institute ofFluid Science, Tohoku University and the School ofMedicine, Tohoku University. The paper describes a result of the fundamental research on the underwater shock wave focusing applied to the ESWL. Quantitatively to visualize the underwater shock waves, various optical flow visualization techniques were successfully used such as holographic interferometry, and shadowgraphs combined with Ima-Con high speed camera. Double exposure holographic interferometric observation revealed the mechanism of generation, propagation and focusing of underwater shock waves. The result of the present research was already used to manufacture a prototype machine and it has already been applied successfully to ESWL crinical treatments. However, despite of success in the clinical treatments, important fundamental questions still remain unsolved, i.e., effects of underwater shock wave focusing on tissue damage during the treatment. Model experiments were conducted to clarify mechanism of the tissue damage associated with the ESWL. Shock-bubble interactions were found responsible to the tissue damage during the ESWL treatment. In order to interprete experimental findings and to predict shock wave behavior and high pressures, a numerical simulation was carried. The numerical results agreed with the experiments.

Effect of hydrodynamic cavitation in the tissue erosion by pulsed high-intensity focused ultrasound (pHIFU)

Science.gov (United States)

Zhou, Yufeng; Gao, Xiaobin Wilson

2016-09-01

High-intensity focused ultrasound (HIFU) is emerging as an effective therapeutic modality in clinics. Besides the thermal ablation, tissue disintegration is also possible because of the interaction between the distorted HIFU bursts and either bubble cloud or boiling bubble. Hydrodynamic cavitation is another type of cavitation and has been employed widely in industry, but its role in mechanical erosion to tissue is not clearly known. In this study, the bubble dynamics immediately after the termination of HIFU exposure in the transparent gel phantom was captured by high-speed photography, from which the bubble displacement towards the transducer and the changes of bubble size was quantitatively determined. The characteristics of hydrodynamic cavitation due to the release of the acoustic radiation force and relaxation of compressed surrounding medium were found to associate with the number of pulses delivered and HIFU parameters (i.e. pulse duration and pulse repetition frequency). Because of the initial big bubble (~1 mm), large bubble expansion (up to 1.76 folds), and quick bubble motion (up to ~1 m s-1) hydrodynamic cavitation is significant after HIFU exposure and may lead to mechanical erosion. The shielding effect of residual tiny bubbles would reduce the acoustic energy delivered to the pre-existing bubble at the focus and, subsequently, the hydrodynamic cavitation effect. Tadpole shape of mechanical erosion in ex vivo porcine kidney samples was similar to the contour of bubble dynamics in the gel. Liquefied tissue was observed to emit towards the transducer through the punctured tissue after HIFU exposure in the sonography. In summary, the release of HIFU exposure-induced hydrodynamic cavitation produces significant bubble expansion and motion, which may be another important mechanism of tissue erosion. Understanding its mechanism and optimizing the outcome would broaden and enhance HIFU applications.

Effect of hydrodynamic cavitation in the tissue erosion by pulsed high-intensity focused ultrasound (pHIFU).

Science.gov (United States)

Zhou, Yufeng; Gao, Xiaobin Wilson

2016-09-21

High-intensity focused ultrasound (HIFU) is emerging as an effective therapeutic modality in clinics. Besides the thermal ablation, tissue disintegration is also possible because of the interaction between the distorted HIFU bursts and either bubble cloud or boiling bubble. Hydrodynamic cavitation is another type of cavitation and has been employed widely in industry, but its role in mechanical erosion to tissue is not clearly known. In this study, the bubble dynamics immediately after the termination of HIFU exposure in the transparent gel phantom was captured by high-speed photography, from which the bubble displacement towards the transducer and the changes of bubble size was quantitatively determined. The characteristics of hydrodynamic cavitation due to the release of the acoustic radiation force and relaxation of compressed surrounding medium were found to associate with the number of pulses delivered and HIFU parameters (i.e. pulse duration and pulse repetition frequency). Because of the initial big bubble (~1 mm), large bubble expansion (up to 1.76 folds), and quick bubble motion (up to ~1 m s -1 ) hydrodynamic cavitation is significant after HIFU exposure and may lead to mechanical erosion. The shielding effect of residual tiny bubbles would reduce the acoustic energy delivered to the pre-existing bubble at the focus and, subsequently, the hydrodynamic cavitation effect. Tadpole shape of mechanical erosion in ex vivo porcine kidney samples was similar to the contour of bubble dynamics in the gel. Liquefied tissue was observed to emit towards the transducer through the punctured tissue after HIFU exposure in the sonography. In summary, the release of HIFU exposure-induced hydrodynamic cavitation produces significant bubble expansion and motion, which may be another important mechanism of tissue erosion. Understanding its mechanism and optimizing the outcome would broaden and enhance HIFU applications.

Normal Reflection Characteristics of One-Dimensional Unsteady Flow Shock Waves on Rigid Walls from Pulse Discharge in Water

Directory of Open Access Journals (Sweden)

Dong Yan

2017-01-01

Full Text Available Strong shock waves can be generated by pulse discharge in water, and the characteristics due to the shock wave normal reflection from rigid walls have important significance to many fields, such as industrial production and defense construction. This paper investigates the effects of hydrostatic pressures and perturbation of wave source (i.e., charging voltage on normal reflection of one-dimensional unsteady flow shock waves. Basic properties of the incidence and reflection waves were analyzed theoretically and experimentally to identify the reflection mechanisms and hence the influencing factors and characteristics. The results indicated that increased perturbation (i.e., charging voltage leads to increased peak pressure and velocity of the reflected shock wave, whereas increased hydrostatic pressure obviously inhibited superposition of the reflection waves close to the rigid wall. The perturbation of wave source influence on the reflected wave was much lower than that on the incident wave, while the hydrostatic pressure obviously affected both incident and reflection waves. The reflection wave from the rigid wall in water exhibited the characteristics of a weak shock wave, and with increased hydrostatic pressure, these weak shock wave characteristics became more obvious.

High speed all optical shear wave imaging optical coherence elastography (Conference Presentation)

Science.gov (United States)

Song, Shaozhen; Hsieh, Bao-Yu; Wei, Wei; Shen, Tueng; O'Donnell, Matthew; Wang, Ruikang K.

2016-03-01

Optical Coherence Elastography (OCE) is a non-invasive testing modality that maps the mechanical property of soft tissues with high sensitivity and spatial resolution using phase-sensitive optical coherence tomography (PhS-OCT). Shear wave OCE (SW-OCE) is a leading technique that relies on the speed of propagating shear waves to provide a quantitative elastography. Previous shear wave imaging OCT techniques are based on repeated M-B scans, which have several drawbacks such as long acquisition time and repeated wave stimulations. Recent developments of Fourier domain mode-locked high-speed swept-source OCT system has enabled enough speed to perform KHz B-scan rate OCT imaging. Here we propose ultra-high speed, single shot shear wave imaging to capture single-shot transient shear wave propagation to perform SW-OCE. The frame rate of shear wave imaging is 16 kHz, at A-line rate of ~1.62 MHz, which allows the detection of high-frequency shear wave of up to 8 kHz. The shear wave is generated photothermal-acoustically, by ultra-violet pulsed laser, which requires no contact to OCE subjects, while launching high frequency shear waves that carries rich localized elasticity information. The image acquisition and processing can be performed at video-rate, which enables real-time 3D elastography. SW-OCE measurements are demonstrated on tissue-mimicking phantoms and porcine ocular tissue. This approach opens up the feasibility to perform real-time 3D SW-OCE in clinical applications, to obtain high-resolution localized quantitative measurement of tissue biomechanical property.

Light storage via slow-light four-wave mixing

International Nuclear Information System (INIS)

Fan, Yun-Fei; Wang, Hai-Hua; Wei, Xiao-Gang; Li, Ai-Jun; Kang, Zhi-Hui; Wu, Jin-Hui; Zhang, Han-Zhuang; Xu, Huai-Liang; Gao, Jin-Yue

2012-01-01

We experimentally demonstrate a light storage via slow-light four-wave mixing in a solid-state medium with a four-level double lambda scheme. Using slow light based on electromagnetically induced transparency, we obtain a slowed four-wave mixing signal pulse together with the slowed probe pulse. During the propagation of light pulses, the storage and retrieval of both the slowed four-wave mixing pulse and the slowed probe pulse are studied by manipulating the intensities of the control fields. -- Highlights: ► A light storage via slow-light four-wave mixing is observed in a solid. ► The probe pulse is slowed under electromagnetically induced transparency. ► A slowed four-wave mixing pulse is obtained by slow light. ► The storage of slowed double pulses is studied.

Single-Cycle Terahertz Pulse Generation from OH1 Crystal via Cherenkov Phase Matching

Science.gov (United States)

Uchida, Hirohisa; Oota, Kengo; Okimura, Koutarou; Kawase, Kodo; Takeya, Kei

2018-06-01

OH1 crystal is an organic nonlinear optical crystal with a large nonlinear optical constant. However, it has dispersion of refractive indices in the terahertz (THz) frequency. This limits the frequencies that satisfy the phase matching conditions for THz wave generation. In this study, we addressed the phase matching conditions for THz wave generation by combining an OH1 crystal with prism-coupled Cherenkov phase matching. We observed the generation of single-cycle THz pulses with a spectrum covering a frequency range of 3 THz. These results prove that combining prism-coupled Cherenkov phase matching with nonlinear optical crystals yields a THz wave generation method that is insusceptible to crystal dispersion.

10-GHz return-to-zero pulse source tunable in wavelength with a single- or multiwavelength output based on four-wave mixing in a newly developed highly nonlinear fiber

DEFF Research Database (Denmark)

Clausen, A. T.; Oxenlowe, L.; Peucheret, Christophe

2001-01-01

In this letter, a novel scheme for a wavelength-tunable pulse source (WTPS) is proposed and characterized. It is based on four-wave mixing (FWM) in a newly developed highly nonlinear fiber between a return-to-zero (RZ) pulsed signal at a fixed wavelength and a continuous wave probe tunable...

Diagnosis of Fibrosis and Activity by a Combined Use of Strain and Shear Wave Imaging in Patients with Liver Disease.

Science.gov (United States)

Yada, Norihisa; Tamaki, Nobuhura; Koizumi, Yohei; Hirooka, Masashi; Nakashima, Osamu; Hiasa, Yoichi; Izumi, Namiki; Kudo, Masatoshi

2017-01-01

Performing shear wave imaging is simple, but can be difficult when inflammation, jaundice, and congestion are present. Therefore, the correct diagnosis of liver fibrosis using shear wave imaging alone might be difficult in mild-to-moderate fibrosis cases. Strain imaging can diagnose liver fibrosis without the influence of inflammation. Therefore, the combined use of strain and shear wave imaging (combinational elastography) for cases without jaundice and congestion might be useful for evaluating fibrosis and inflammation. We enrolled consecutive patients with liver disease, without jaundice or liver congestion. Strain and shear wave imaging, blood tests, and liver biopsy were performed on the same day. The liver fibrosis index (LF index) was calculated by strain imaging; real-time tissue elastography, and the shear wave velocity (Vs) was calculated by shear wave imaging. Fibrosis index (F index) and activity index (A index) were calculated as a multiple regression equation for determining hepatic fibrosis and inflammation using histopathological diagnosis as the gold standard. The diagnostic ability of F index for fibrosis and A index for inflammation were compared using LF index and Vs. The total number of enrolled cases was 388. The area under the receiver operating characteristic (AUROC) was 0.87, 0.80, 0.83, and 0.80, at diagnosis of fibrosis stage with an F index of F1 or higher, F2 or higher, F3 or higher, and F4, respectively. The AUROC was 0.94, 0.74, and 0.76 at diagnosis of activity grade with an A index of A1 or higher, A2 or higher, and A3, respectively. The diagnostic ability of F index for liver fibrosis and A index for inflammation was higher than for other conventional diagnostic values. The combined use of strain and shear wave imaging (combinational elastography) might increase the positive diagnosis of liver fibrosis and inflammation. © 2017 S. Karger AG, Basel.

Dynamic tissue phantoms and their use in assessment of a noninvasive optical plethysmography imaging device

Science.gov (United States)

Thatcher, Jeffrey E.; Plant, Kevin D.; King, Darlene R.; Block, Kenneth L.; Fan, Wensheng; DiMaio, J. Michael

2014-05-01

Non-contact photoplethysmography (PPG) has been studied as a method to provide low-cost and non-invasive medical imaging for a variety of near-surface pathologies and two dimensional blood oxygenation measurements. Dynamic tissue phantoms were developed to evaluate this technology in a laboratory setting. The purpose of these phantoms was to generate a tissue model with tunable parameters including: blood vessel volume change; pulse wave frequency; and optical scattering and absorption parameters. A non-contact PPG imaging system was evaluated on this model and compared against laser Doppler imaging (LDI) and a traditional pulse oximeter. Results indicate non-contact PPG accurately identifies pulse frequency and appears to identify signals from optically dense phantoms with significantly higher detection thresholds than LDI.

Laser-Neuron Interaction with Femtosecond Beat-Modulated 800-1200 nm Photon Beams, as the Treatment of Brain Cancer Tissue. Laser Neurophysics

Science.gov (United States)

Stefan, V. Alexander

2011-03-01

I propose a novel mechanism for the brain cancer tissue treatment: nonlinear interaction of ultrashort pulses of beat-photon, (ω1 -- ω2) , or double-photon, (ω1 +ω2) , beams with the cancer tissue. The multiphoton scattering is described via photon diffusion equation. The open-scull cerebral tissue can be irradiated with the beat-modulated photon pulses with the laser irradiances in the range of a few mW/cm2 , and repetition rate of a few 100s Hz generated in the beat-wave driven free electron laser. V. Stefan, B. I. Cohen, and C. Joshi, Nonlinear Mixing of Electromagnetic Waves in PlasmasScience 27 January 1989: V. Alexander Stefan, Genomic Medical Physics: A New Physics in the Making, (S-U-Press, 2008).} This highly accurate cancer tissue ablation removal may prove to be an efficient method for the treatment of brain cancer. Work supported in part by Nikola Tesla Laboratories (Stefan University), La Jolla, CA.

Plasma wakefields driven by an incoherent combination of laser pulses: a path towards high-average power laser-plasma accelerators

Energy Technology Data Exchange (ETDEWEB)

Benedetti, C.; Schroeder, C.B.; Esarey, E.; Leemans, W.P.

2014-05-01

he wakefield generated in a plasma by incoherently combining a large number of low energy laser pulses (i.e.,without constraining the pulse phases) is studied analytically and by means of fully-self-consistent particle-in-cell simulations. The structure of the wakefield has been characterized and its amplitude compared with the amplitude of the wake generated by a single (coherent) laser pulse. We show that, in spite of the incoherent nature of the wakefield within the volume occupied by the laser pulses, behind this region the structure of the wakefield can be regular with an amplitude comparable or equal to that obtained from a single pulse with the same energy. Wake generation requires that the incoherent structure in the laser energy density produced by the combined pulses exists on a time scale short compared to the plasma period. Incoherent combination of multiple laser pulses may enable a technologically simpler path to high-repetition rate, high-average power laser-plasma accelerators and associated applications.

Time-resolved measurements with intense ultrashort laser pulses: a 'molecular movie' in real time

International Nuclear Information System (INIS)

Rudenko, A; Ergler, Th; Feuerstein, B; Zrost, K; Schroeter, C D; Moshammer, R; Ullrich, J

2007-01-01

We report on the high-resolution multidimensional real-time mapping of H 2 + and D 2 + nuclear wave packets performed employing time-resolved three-dimensional Coulomb explosion imaging with intense laser pulses. Exploiting a combination of a 'reaction microscope' spectrometer and a pump-probe setup with two intense 6-7 fs laser pulses, we simultaneously visualize both vibrational and rotational motion of the molecule, and obtain a sequence of snapshots of the squared ro-vibrational wave function with time-step resolution of ∼ 0.3 fs, allowing us to reconstruct a real-time movie of the ultrafast molecular motion. We observe fast dephasing, or 'collapse' of the vibrational wave packet and its subsequent revival, as well as signatures of rotational excitation. For D 2 + we resolve also the fractional revivals resulting from the interference between the counter-propagating parts of the wave packet

Theory of Self-pulsing in Photonic Crystal Fano Lasers

DEFF Research Database (Denmark)

Rasmussen, Thorsten Svend; Yu, Yi; Mørk, Jesper

2017-01-01

-dispersive Fano mirror, the laser frequency and the threshold gain. The model is based upon a combination of conventional laser rate equations and coupled-mode theory. The dynamical model is used to demonstrate how the laser has two regimes of operation, continuous-wave output and self-pulsing, and these regimes......Laser self-pulsing was a phenomenon exclusive to macroscopic lasers until recently, where self-starting laser pulsation in a microscopic photonic crystal Fano laser was reported. In this paper a theoretical model is developed to describe the Fano laser, including descriptions of the highly...

Frequency-locked pulse sequencer for high-frame-rate monochromatic tissue motion imaging.

Science.gov (United States)

Azar, Reza Zahiri; Baghani, Ali; Salcudean, Septimiu E; Rohling, Robert

2011-04-01

To overcome the inherent low frame rate of conventional ultrasound, we have previously presented a system that can be implemented on conventional ultrasound scanners for high-frame-rate imaging of monochromatic tissue motion. The system employs a sector subdivision technique in the sequencer to increase the acquisition rate. To eliminate the delays introduced during data acquisition, a motion phase correction algorithm has also been introduced to create in-phase displacement images. Previous experimental results from tissue- mimicking phantoms showed that the system can achieve effective frame rates of up to a few kilohertz on conventional ultrasound systems. In this short communication, we present a new pulse sequencing strategy that facilitates high-frame-rate imaging of monochromatic motion such that the acquired echo signals are inherently in-phase. The sequencer uses the knowledge of the excitation frequency to synchronize the acquisition of the entire imaging plane to that of an external exciter. This sequencing approach eliminates any need for synchronization or phase correction and has applications in tissue elastography, which we demonstrate with tissue-mimicking phantoms. © 2011 IEEE

Comparison of pulsed dye laser versus combined pulsed dye laser and Nd:YAG laser in the treatment of inflammatory acne vulgaris.

Science.gov (United States)

Salah El Din, Manal Mohamed; Samy, Nevien Ahmed; Salem, Amira Eid

2017-06-01

Both pulsed dye laser and combined 585/1064-nm (sequential dual-wavelength PDL and Nd:YAG) laser improves inflammatory skin disorders including acne vulgaris. To compare the efficacy of 585-nm pulsed dye laser versus sequential dual-wavelength PDL and Nd:YAG in treatment of acne vulgaris. Thirty patients with acne vulgaris were treated by PDL alone on half of the face while contra lateral half was treated by combined 585/1064 nm laser. The study showed that inflammatory acne lesions count was significantly reduced by 82.5% (p 0.0001) on PDL sides and by 83.5% (p 0.00001) on combined 585/1064-nm side after 8 weeks, while reduction of non-inflammatory acne lesions was observed at 8 weeks by 58.4% and 71.5% respectively. However, difference between the two modalities was not statistically significant. PDL and combined PDL/Nd:YAG laser treatment were found to be an effective, safe and well-tolerated treatment option for inflammatory and non-inflammatory acne vulgaris.

Design study of a traveling-wave Thomson-scattering experiment for the realization of optical free electron lasers

Energy Technology Data Exchange (ETDEWEB)

Steiniger, Klaus; Loeser, Markus; Pausch, Richard; Schramm, Ulrich [Helmholtz-Zentrum Dresden-Rossendorf (Germany); Technische Universitaet Dresden (Germany); Albach, Daniel; Debus, Alexander; Roeser, Fabian; Siebold, Matthias; Bussmann, Michael [Helmholtz-Zentrum Dresden-Rossendorf (Germany)

2016-07-01

We present an experimental setup strategy for the realization of an optical free-electron laser (OFEL) in the Traveling-Wave Thomson-Scattering geometry (TWTS). In TWTS, the electric field of petawatt class, pulse-front tilted laser pulses is used to provide an optical undulator field. This is passed by a relativistic electron bunch so that electron direction of motion and laser propagation direction enclose an interaction angle. The combination of side scattering and pulse-front tilt provides continuous overlap of electrons and laser pulse over meter scale distances which are achieved with centimeter wide laser pulses. An experimental challenge lies in shaping of these wide laser pulses in terms of laser dispersion compensation along the electron trajectory and focusing. In the talk we show how diffraction gratings in combination with mirrors are used to introduce and control dispersion of the laser in order to provide a plane wave laser field along the electron trajectory. Furthermore we give tolerance limits on alignment errors to operate the OFEL. Example setups illustrate functioning and demonstrate feasibility of the scheme.

Traveling wave laser system

International Nuclear Information System (INIS)

Gregg, D.W.; Kidder, R.E.; Biehl, A.T.

1975-01-01

The invention broadly involves a method and means for generating a traveling wave laser pulse and is basically analogous to a single pass light amplifier system. However, the invention provides a traveling wave laser pulse of almost unlimited energy content, wherein a gain medium is pumped in a traveling wave mode, the traveling wave moving at essentially the velocity of light to generate an amplifying region or zone which moves through the medium at the velocity of light in the presence of directed stimulating radiation, thereby generating a traveling coherent, directed radiation pulse moving with the amplification zone through the gain medium. (U.S.)

PULSE SYNTHESIZING GENERATOR

Science.gov (United States)

Kerns, Q.A.

1963-08-01

>An electronlc circuit for synthesizing electrical current pulses having very fast rise times includes several sinewave generators tuned to progressively higher harmonic frequencies with signal amplitudes and phases selectable according to the Fourier series of the waveform that is to be synthesized. Phase control is provided by periodically triggering the generators at precisely controlled times. The outputs of the generators are combined in a coaxial transmission line. Any frequency-dependent delays that occur in the transmission line can be readily compensated for so that the desired signal wave shape is obtained at the output of the line. (AEC)

Pitfalls in the ankle-brachial index and brachial-ankle pulse wave velocity

Directory of Open Access Journals (Sweden)

Ato D

2018-04-01

Full Text Available Dai Ato Gakujutsu Shien Co., Ltd., Tokyo, Japan Background: The ankle-brachial index (ABI and pulse wave velocity (PWV are indices of atherosclerosis and arterial stiffness. The Japan-made measuring devices of those indices have spread widely because of their convenience and the significance of the parameters. However, studies that comprehensively discuss the various pitfalls in using these indices are not available.Methods: This study presents several representative pitfalls in using the ABI and brachial-ankle PWV (baPWV by showing the result sheets of the device, “the Vascular Profiler”. Furthermore, some considerations when utilizing these indices in the future are also discussed.Results: Several diseases such as arteriosclerosis obliterans (ASO, arterial calcification in the lower limb, arterial stenosis in the right upper-limb, aortic valve diseases, arterial stenosis in the upper-limb of the contralateral side of the hemodialysis access, are the representative pitfalls when evaluating ABI and baPWV. Moreover, a measurement error is found to actually exist. Furthermore, same phenomena are considered most likely to occur when using other similar indices and devices.Conclusion: The ABI and baPWV are the useful and significant biomarkers. Nevertheless, caution is sometimes necessary when interpreting them. Moreover, rigorous patient exclusion criteria should be considered when using those indices in the severely conditioned patient population. And the results of this study can be applied to enhance the literacy using other indices, such as the cardio-ankle vascular index and other similar devices. Keywords: ankle-brachial index, pulse wave velocity, peripheral arterial disease, aortic valve disease, hemodialysis

Measuring and engineering the atomic mass density wave of a Gaussian mass-polariton pulse in optical fibers

Science.gov (United States)

Partanen, Mikko; Tulkki, Jukka

2018-02-01

Conventional theories of electromagnetic waves in a medium assume that only the energy of the field propagates inside the medium. Consequently, they neglect the transport of mass density by the medium atoms. We have recently presented foundations of a covariant theory of light propagation in a nondispersive medium by considering a light wave simultaneously with the dynamics of the medium atoms driven by optoelastic forces [Phys. Rev. A 95, 063850 (2017)]. In particular, we have shown that the mass is transferred by an atomic mass density wave (MDW), which gives rise to mass-polariton (MP) quasiparticles, i.e., covariant coupled states of the field and matter having a nonzero rest mass. Another key observation of the mass-polariton theory of light is that, in common semiconductors, most of the momentum of light is transferred by moving atoms, e.g., 92% in the case of silicon. In this work, we generalize the MP theory of light for dispersive media and consider experimental measurement of the mass transferred by the MDW atoms when an intense light pulse propagates in a silicon fiber. In particular, we consider optimal intensity and time dependence of a Gaussian pulse and account for the breakdown threshold irradiance of the material. The optical shock wave property of the MDW, which propagates with the velocity of light instead of the velocity of sound, prompts for engineering of novel device concepts like very high frequency mechanical oscillators not limited by the acoustic cutoff frequency.

Travelling Wave Pulse Coupled Oscillator (TWPCO) Using a Self-Organizing Scheme for Energy-Efficient Wireless Sensor Networks.

Science.gov (United States)

Al-Mekhlafi, Zeyad Ghaleb; Hanapi, Zurina Mohd; Othman, Mohamed; Zukarnain, Zuriati Ahmad

2017-01-01

Recently, Pulse Coupled Oscillator (PCO)-based travelling waves have attracted substantial attention by researchers in wireless sensor network (WSN) synchronization. Because WSNs are generally artificial occurrences that mimic natural phenomena, the PCO utilizes firefly synchronization of attracting mating partners for modelling the WSN. However, given that sensor nodes are unable to receive messages while transmitting data packets (due to deafness), the PCO model may not be efficient for sensor network modelling. To overcome this limitation, this paper proposed a new scheme called the Travelling Wave Pulse Coupled Oscillator (TWPCO). For this, the study used a self-organizing scheme for energy-efficient WSNs that adopted travelling wave biologically inspired network systems based on phase locking of the PCO model to counteract deafness. From the simulation, it was found that the proposed TWPCO scheme attained a steady state after a number of cycles. It also showed superior performance compared to other mechanisms, with a reduction in the total energy consumption of 25%. The results showed that the performance improved by 13% in terms of data gathering. Based on the results, the proposed scheme avoids the deafness that occurs in the transmit state in WSNs and increases the data collection throughout the transmission states in WSNs.

Travelling Wave Pulse Coupled Oscillator (TWPCO) Using a Self-Organizing Scheme for Energy-Efficient Wireless Sensor Networks

Science.gov (United States)

Hanapi, Zurina Mohd; Othman, Mohamed; Zukarnain, Zuriati Ahmad

2017-01-01

Recently, Pulse Coupled Oscillator (PCO)-based travelling waves have attracted substantial attention by researchers in wireless sensor network (WSN) synchronization. Because WSNs are generally artificial occurrences that mimic natural phenomena, the PCO utilizes firefly synchronization of attracting mating partners for modelling the WSN. However, given that sensor nodes are unable to receive messages while transmitting data packets (due to deafness), the PCO model may not be efficient for sensor network modelling. To overcome this limitation, this paper proposed a new scheme called the Travelling Wave Pulse Coupled Oscillator (TWPCO). For this, the study used a self-organizing scheme for energy-efficient WSNs that adopted travelling wave biologically inspired network systems based on phase locking of the PCO model to counteract deafness. From the simulation, it was found that the proposed TWPCO scheme attained a steady state after a number of cycles. It also showed superior performance compared to other mechanisms, with a reduction in the total energy consumption of 25%. The results showed that the performance improved by 13% in terms of data gathering. Based on the results, the proposed scheme avoids the deafness that occurs in the transmit state in WSNs and increases the data collection throughout the transmission states in WSNs. PMID:28056020

Combination of elastography and tissue quantification using the acoustic radiation force impulse (ARFI) technology for differential diagnosis of breast masses.

Science.gov (United States)

Tozaki, Mitsuhiro; Isobe, Sachiko; Sakamoto, Masaaki

2012-10-01

We evaluated the diagnostic performance of elastography and tissue quantification using acoustic radiation force impulse (ARFI) technology for differential diagnosis of breast masses. There were 161 mass lesions. First, lesion correspondence on ARFI elastographic images to those on the B-mode images was evaluated: no findings on ARFI images (pattern 1), lesions that were bright inside (pattern 2), lesions that were dark inside (pattern 4), lesions that contained both bright and dark areas (pattern 3). In addition, pattern 4 was subdivided into 4a (dark area same as B-mode lesion) and 4b (dark area larger than lesion). Next, shear wave velocity (SWV) was measured using virtual touch tissue quantification. There were 13 pattern 1 lesions and five pattern 2 lesions; all of these lesions were benign, whereas all pattern 4b lesions (n = 43) were malignant. When the value of 3.59 m/s was chosen as the cutoff value, the combination of elastography and tissue quantification showed 91 % (83-91) sensitivity, 93 % (65-70) specificity, and 92 % (148-161) accuracy. The combination of elastography and tissue quantification is thought to be a promising ultrasound technique for differential diagnosis of breast-mass lesions.

Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity

NARCIS (Netherlands)

L.M. van Bortel (Luc); S. Laurent (Stephane); P. Boutouyrie (Pierre); P. Chowienczyk (Phil); J.K. Cruickshank (Kennedy); T.L.M. de Backer (Tine); J. Filipovsky (Jan); S. Huybrechts (Sofie); F.U.S. Mattace Raso (Francesco); A.D. Protogerou (Athanase); G. Schillaci (Giuseppe); P. Segers (Patrick); S. Vermeersch (Steve); T. Weber (Thomas)

2012-01-01

textabstractStiffness of elastic arteries like the aorta predicts cardiovascular risk. By directly reflecting arterial stiffness, having the best predictive value for cardiovascular outcome and the ease of its measurement, carotid-femoral pulse wave velocity is now considered the gold standard for

Multiharmonic Frequency-Chirped Transducers for Surface-Acoustic-Wave Optomechanics

Science.gov (United States)

Weiß, Matthias; Hörner, Andreas L.; Zallo, Eugenio; Atkinson, Paola; Rastelli, Armando; Schmidt, Oliver G.; Wixforth, Achim; Krenner, Hubert J.

2018-01-01

Wide-passband interdigital transducers are employed to establish a stable phase lock between a train of laser pulses emitted by a mode-locked laser and a surface acoustic wave generated electrically by the transducer. The transducer design is based on a multiharmonic split-finger architecture for the excitation of a fundamental surface acoustic wave and a discrete number of its overtones. Simply by introducing a variation of the transducer's periodicity p , a frequency chirp is added. This combination results in wide frequency bands for each harmonic. The transducer's conversion efficiency from the electrical to the acoustic domain is characterized optomechanically using single quantum dots acting as nanoscale pressure sensors. The ability to generate surface acoustic waves over a wide band of frequencies enables advanced acousto-optic spectroscopy using mode-locked lasers with fixed repetition rate. Stable phase locking between the electrically generated acoustic wave and the train of laser pulses is confirmed by performing stroboscopic spectroscopy on a single quantum dot at a frequency of 320 MHz. Finally, the dynamic spectral modulation of the quantum dot is directly monitored in the time domain combining stable phase-locked optical excitation and time-correlated single-photon counting. The demonstrated scheme will be particularly useful for the experimental implementation of surface-acoustic-wave-driven quantum gates of optically addressable qubits or collective quantum states or for multicomponent Fourier synthesis of tailored nanomechanical waveforms.

Control of periodic surface structures on silicon by combined temporal and polarization shaping of femtosecond laser pulses

Science.gov (United States)

Fraggelakis, F.; Stratakis, E.; Loukakos, P. A.

2018-06-01

We demonstrate the capability to exercise advanced control on the laser-induced periodic surface structures (LIPSS) on silicon by combining the effect of temporal shaping, via tuning the interpulse temporal delay between double femtosecond laser pulses, along with the independent manipulation of the polarization state of each of the individual pulses. For this, cross-polarized (CP) as well as counter-rotating (CR) double circularly polarized pulses have been utilized. The pulse duration was 40 fs and the central wavelength of 790 nm. The linearly polarized double pulses are generated by a modified Michelson interferometer allowing the temporal delay between the pulses to vary from Δτ = -80 ps to Δτ = +80 ps with an accuracy of 0.2 fs. We show the significance of fluence balance between the two pulse components and its interplay with the interpulse delay and with the order of arrival of the individually polarized pulse components of the double pulse sequence on the final surface morphology. For the case of CR pulses we found that when the pulses are temporally well separated the surface morphology attains no axial symmetry. But strikingly, when the two CP pulses temporally overlap, we demonstrate, for the first time in our knowledge, the detrimental effect that the phase delay has on the ripple orientation. Our results provide new insight showing that temporal pulse shaping in combination with polarization control gives a powerful tool for drastically controlling the surface nanostructure morphology.

Thermal distribution in biological tissue at laser induced fluorescence and photodynamic therapy

Science.gov (United States)

Krasnikov, I. V.; Seteikin, A. Yu.; Drakaki, E.; Makropoulou, M.

2012-03-01

Laser induced fluorescence spectroscopy and photodynamic therapy (PDT) are techniques currently introduced in clinical applications for visualization and local destruction of malignant tumours as well as premalignant lesions. During the laser irradiation of tissues for the diagnostic and therapeutic purposes, the absorbed optical energy generates heat, although the power density of the treatment light for surface illumination is normally low enough not to cause any significantly increased tissue temperature. In this work we tried to evaluate the utility of Monte Carlo modeling for simulating the temperature fields and the dynamics of heat conduction into the skin tissue under several laser irradiation conditions with both a pulsed UV laser and a continuous wave visible laser beam. The analysis of the results showed that heat is not localized on the surface, but it is collected inside the tissue. By varying the boundary conditions on the surface and the type of the laser radiation (continuous or pulsed) we can reach higher than normal temperature inside the tissue without simultaneous formation of thermally damaged tissue (e.g. coagulation or necrosis zone).

Experimental investigation on a diode-pumped cesium-vapor laser stably operated at continuous-wave and pulse regime.

Science.gov (United States)

Chen, Fei; Xu, Dongdong; Gao, Fei; Zheng, Changbin; Zhang, Kuo; He, Yang; Wang, Chunrui; Guo, Jin

2015-05-04

Employing a fiber-coupled diode-laser with a center wavelength of 852.25 nm and a line width of 0.17 nm, experimental investigation on diode-end-pumped cesium (Cs) vapor laser stably operated at continuous-wave (CW) and pulse regime is carried out. A 5 mm long cesium vapor cell filled with 60 kPa helium and 20 kPa ethane is used as laser medium. Using an output coupler with reflectivity of 48.79%, 1.26 W 894.57 nm CW laser is obtained at an incident pump power of 4.76 W, corresponding an optical-optical efficiency of 26.8% and a slope-efficiency of 28.8%, respectively. The threshold temperature is 67.5 °C. Stable pulsed cesium laser with a maximum average output power of 2.6 W is obtained at a repetition rate of 76 Hz, and the pulse repetition rate can be extend to 1 kHz with a pulse width of 18 μs.

Association of pulse wave velocity and pulse pressure with decline in kidney function.

Science.gov (United States)

Kim, Chang Seong; Kim, Ha Yeon; Kang, Yong Un; Choi, Joon Seok; Bae, Eun Hui; Ma, Seong Kwon; Kim, Soo Wan

2014-05-01

The association between arterial stiffness and decline in kidney function in patients with mild to moderate chronic kidney disease (CKD) is not well established. This study investigated whether pulse wave velocity (PWV) and pulse pressure (PP) are independently associated with glomerular filtration rate (GFR) and rapid decline in kidney function in early CKD. Carotid femoral PWV (cfPWV), brachial-ankle PWV (baPWV), and PP were measured in a cohort of 913 patients (mean age, 63±10 years; baseline estimated GFR, 84±18 mL/min/1.73 m(2) ). Estimated GFR was measured at baseline and at follow-up. The renal outcome examined was rapid decline in kidney function (estimated GFR loss, >3 mL/min/1.73 m(2) per year). The median follow-up duration was 3.2 years. Multivariable adjusted linear regression model indicated that arterial PWV (both cfPWV and baPWV) and PP increased as estimated GFR declined, but neither was associated with kidney function after adjustment for various covariates. Multivariable logistic regression analysis found that cfPWV and baPWV were not associated with rapid decline in kidney function (odds ratio [OR], 1.39, 95% confidence interval [CI], 0.41-4.65; OR, 2.51, 95% CI, 0.66-9.46, respectively), but PP was (OR, 1.22, 95% CI, 1.01-1.48; P=.045). Arterial stiffness assessed using cfPWV and baPWV was not correlated with lower estimated GFR and rapid decline in kidney function after adjustment for various confounders. Thus, PP is an independent risk factor for rapid decline in kidney function in populations with relatively preserved kidney function (estimated GFR ≥30 mL/min/1.73 m(2) ). ©2014 Wiley Periodicals, Inc.

The Effects of TM on Concurrent Heart Rate, Peripheral Blood Pulse Volume, and the Alpha Wave Frequency.

Science.gov (United States)

Lukas, Jerome S.

Through observation of 26 subjects over a 3 month period, this research project measured the effects of transcendental meditation (TM) on concurrent heart rate, peripheral blood pulse volume, and the alpha wave frequency. The subjects were assigned randomly to three groups. One group practiced TM as prescribed by the International Meditation…

Optical coherence tomography detection of shear wave propagation in inhomogeneous tissue equivalent phantoms and ex-vivo carotid artery samples

Science.gov (United States)

Razani, Marjan; Luk, Timothy W.H.; Mariampillai, Adrian; Siegler, Peter; Kiehl, Tim-Rasmus; Kolios, Michael C.; Yang, Victor X.D.

2014-01-01

In this work, we explored the potential of measuring shear wave propagation using optical coherence elastography (OCE) in an inhomogeneous phantom and carotid artery samples based on a swept-source optical coherence tomography (OCT) system. Shear waves were generated using a piezoelectric transducer transmitting sine-wave bursts of 400 μs duration, applying acoustic radiation force (ARF) to inhomogeneous phantoms and carotid artery samples, synchronized with a swept-source OCT (SS-OCT) imaging system. The phantoms were composed of gelatin and titanium dioxide whereas the carotid artery samples were embedded in gel. Differential OCT phase maps, measured with and without the ARF, detected the microscopic displacement generated by shear wave propagation in these phantoms and samples of different stiffness. We present the technique for calculating tissue mechanical properties by propagating shear waves in inhomogeneous tissue equivalent phantoms and carotid artery samples using the ARF of an ultrasound transducer, and measuring the shear wave speed and its associated properties in the different layers with OCT phase maps. This method lays the foundation for future in-vitro and in-vivo studies of mechanical property measurements of biological tissues such as vascular tissues, where normal and pathological structures may exhibit significant contrast in the shear modulus. PMID:24688822

High-speed photography of plasma during excimer laser-tissue interaction

International Nuclear Information System (INIS)

Murray, Andrea K; Dickinson, Mark R

2004-01-01

During high fluence laser-tissue interaction, ablation of tissue occurs, debris is removed from the ablation site and is then ejected at high velocity. This debris may be observed as a combination of luminous plasma and non-luminous plume, both of which have the potential to shield the ablation site. This study examined the role of ablation debris in shielding the tissue and determined its effects on the ablation rate over a range of laser pulse energies, pulse repetition rates and pulse numbers for dentine; the velocity differences between hard and soft tissues were also examined. High-speed photography was carried out at up to 1 x 10 8 frames per second. A maximum velocity of 2.58 ± 0.52 x 10 4 m s -1 was recorded for dentine debris within the first 10 ns following ejection. The maximum duration of tissue shielding due to a single pulse, determined by attenuation of a probe beam, was found to be ∼7 ms, ∼80 μs of which was due to luminous plasma and the remainder due to the non-luminous plume

LASER BIOLOGY AND MEDICINE: Effect of repetitive laser pulses on the electrical conductivity of intervertebral disc tissue

Science.gov (United States)

Omel'chenko, A. I.; Sobol', E. N.

2009-03-01

The thermomechanical effect of 1.56-μm fibre laser pulses on intervertebral disc cartilage has been studied using ac conductivity measurements with coaxial electrodes integrated with an optical fibre for laser radiation delivery to the tissue. The observed time dependences of tissue conductivity can be interpreted in terms of hydraulic effects and thermomechanical changes in tissue structure. The laserinduced changes in the electrical parameters of the tissue are shown to correlate with the structural changes, which were visualised using shadowgraph imaging. Local ac conductivity measurements in the bulk of tissue can be used to develop a diagnostic/monitoring system for laser regeneration of intervertebral discs.

Short-term effects of a standardized glucose load on region-specific aortic pulse wave velocity assessed by MRI

NARCIS (Netherlands)

Jonker, J.T.; Tjeerdema, N.; Hensen, L.C.; Lamb, H.J.; Romijn, J.A.; Smit, J.W.; Westenberg, J.J.; Roos, A. de

2014-01-01

PURPOSE: To assess the short-term effects of a standardized oral glucose load on regional aortic pulse wave velocity (PWV) using two-directional in-plane velocity encoded MRI. MATERIALS AND METHODS: A randomized, controlled intervention was performed in 16 male subjects (mean +/- standard deviation:

Measurements of the plasma density in the FTU tokamak by a pulsed time-of-flight X-wave refractometer

International Nuclear Information System (INIS)

Petrov, V. G.; Petrov, A. A.; Malyshev, A. Yu.; De Benedetti, M.; Tudisco, O.

2008-01-01

On-line control over the plasma density in tokamaks (especially, in long-term discharges) requires reliable measurements of the averaged plasma density. For this purpose, a new method of density measurements-a pulsed time-of-flight plasma refractometry-was developed and tested in the T-11M tokamak. This method allows one to determine the averaged density from the measured time delay of nanosecond microwave pulses propagating through the plasma. For an O-wave, the measured time delay is proportional to the line-averaged density and is independent of the density profile (f>>f p ) τ o ∼ k o 1/f 2 ∫ l N(x)dx. Here, f is the frequency of the probing wave, f p is the plasma frequency, l= 4 a is the path length for two-pass probing in the equatorial plane, a is the plasma minor radius, k O and k X are numerical factors, f c is the electron-cyclotron frequency at the axis of the plasma column, and f p >>f c , f. Measurements of the time delay provide the same information as plasma interferometry, though they do no employ the effect of interference. When the conditions f p >>f c , f are not satisfied, the measured time delay depends on the shape of the density profile. In this case, in order to determine the average density regardless of the density profile, it is necessary to perform simultaneous measurements at several probing frequencies in order to determine the average density. In ITER (Bt ∼ 5T), a spectral window between the lower and upper cutoff frequencies in the range of 50-100 GHz can be used for pulsed time-of-flight X-wave refractometry. This appreciably simplifies the diagnostics and eliminates the problem of the first mirror. In this paper, the first results obtained in the FTU tokamak with a prototype of the ITER pulsed time-of-flight refractometer are presented. The geometry and layout of experiments similar to the planned ITER experiments are described. The density measured by pulsed time-of-flight refractometry is shown to agree well with the

The association between pulse wave velocity and cognitive function: the Sydney Memory and Ageing Study.

Science.gov (United States)

Singer, Joel; Trollor, Julian N; Crawford, John; O'Rourke, Michael F; Baune, Bernhard T; Brodaty, Henry; Samaras, Katherine; Kochan, Nicole A; Campbell, Lesley; Sachdev, Perminder S; Smith, Evelyn

2013-01-01

Pulse wave velocity (PWV) is a measure of arterial stiffness and its increase with ageing has been associated with damage to cerebral microvessels and cognitive impairment. This study examined the relationship between carotid-femoral PWV and specific domains of cognitive function in a non-demented elderly sample. Data were drawn from the Sydney Memory and Ageing Study, a cohort study of non-demented community-dwelling individuals aged 70-90 years, assessed in successive waves two years apart. In Wave 2, PWV and cognitive function were measured in 319 participants. Linear regression was used to analyse the cross-sectional relationship between arterial stiffness and cognitive function in the whole sample, and separately for men and women. Analysis of covariance was used to assess potential differences in cognition between subjects with PWV measurements in the top and bottom tertiles of the cohort. Covariates were age, education, body mass index, pulse rate, systolic blood pressure, cholesterol, depression, alcohol, smoking, hormone replacement therapy, apolipoprotein E ε4 genotype, use of anti-hypertensive medications, history of stroke, transient ischemic attack, myocardial infarction, angina, diabetes, and also sex for the whole sample analyses. There was no association between PWV and cognition after Bonferroni correction for multiple testing. When examining this association for males and females separately, an association was found in males, with higher PWV being associated with lower global cognition and memory, however, a significant difference between PWV and cognition between males and females was not found. A higher level of PWV was not associated with lower cognitive function in the whole sample.

Response of a Hypersonic Boundary Layer to Freestream Pulse Acoustic Disturbance

Directory of Open Access Journals (Sweden)

Zhenqing Wang

2014-01-01

Full Text Available The response of hypersonic boundary layer over a blunt wedge to freestream pulse acoustic disturbance was investigated. The stability characteristics of boundary layer for freestream pulse wave and continuous wave were analyzed comparatively. Results show that freestream pulse disturbance changes the thermal conductivity characteristics of boundary layer. For pulse wave, the number of main disturbance clusters decreases and the frequency band narrows along streamwise. There are competition and disturbance energy transfer among different modes in boundary layer. The dominant mode of boundary layer has an inhibitory action on other modes. Under continuous wave, the disturbance modes are mainly distributed near fundamental and harmonic frequencies, while under pulse wave, the disturbance modes are widely distributed in different modes. For both pulse and continuous waves, most of disturbance modes slide into a lower-growth or decay state in downstream, which is tending towards stability. The amplitude of disturbance modes in boundary layer under continuous wave is considerably larger than pulse wave. The growth rate for the former is also considerably larger than the later the disturbance modes with higher growth are mainly distributed near fundamental and harmonic frequencies for the former, while the disturbance modes are widely distributed in different frequencies for the latter.

Response of a hypersonic boundary layer to freestream pulse acoustic disturbance.

Science.gov (United States)

Wang, Zhenqing; Tang, Xiaojun; Lv, Hongqing

2014-01-01

The response of hypersonic boundary layer over a blunt wedge to freestream pulse acoustic disturbance was investigated. The stability characteristics of boundary layer for freestream pulse wave and continuous wave were analyzed comparatively. Results show that freestream pulse disturbance changes the thermal conductivity characteristics of boundary layer. For pulse wave, the number of main disturbance clusters decreases and the frequency band narrows along streamwise. There are competition and disturbance energy transfer among different modes in boundary layer. The dominant mode of boundary layer has an inhibitory action on other modes. Under continuous wave, the disturbance modes are mainly distributed near fundamental and harmonic frequencies, while under pulse wave, the disturbance modes are widely distributed in different modes. For both pulse and continuous waves, most of disturbance modes slide into a lower-growth or decay state in downstream, which is tending towards stability. The amplitude of disturbance modes in boundary layer under continuous wave is considerably larger than pulse wave. The growth rate for the former is also considerably larger than the later the disturbance modes with higher growth are mainly distributed near fundamental and harmonic frequencies for the former, while the disturbance modes are widely distributed in different frequencies for the latter.

Thermal wave propagation in the pulsed laser irradiation of media with thermal memory

International Nuclear Information System (INIS)

Galovic, S.; Kostoski, D.; Stamboliev, G.; Suljovrujic, E.

2002-01-01

Complete text of publication follows. If a sample is exposed to the influence of laser radiation part of its energy is absorbed and converted in heat. The heat generated in this way is transferred through the sample as heat waves, resulting in various effects (so called photothermal effects). A large number of nondestructive diagnostic methods are based on recording of these effects. It is necessary to create a good model in order to understand and correctly describe the measured results of heat transfer in different media. In a certain number of materials and structures, such as complex biological materials, polymers, metals excited by very short laser pulses etc., the property of thermal memory has been experimentally observed. Starting with the hyperbolic equation that describes heat transfer processes of such media, in this paper has been developed a model of laser-excited heat waves propagation in order to enable application of photothermal techniques in characterization of these media. The cases of optically opaque and transparent samples are considered. The influence of various backings on photothermal waves has also been analyzed. The results are compared to the previous models

Spiral wave classification using normalized compression distance: Towards atrial tissue spatiotemporal electrophysiological behavior characterization.

Science.gov (United States)

Alagoz, Celal; Guez, Allon; Cohen, Andrew; Bullinga, John R

2015-08-01

Analysis of electrical activation patterns such as re-entries during atrial fibrillation (Afib) is crucial in understanding arrhythmic mechanisms and assessment of diagnostic measures. Spiral waves are a phenomena that provide intuitive basis for re-entries occurring in cardiac tissue. Distinct spiral wave behaviors such as stable spiral waves, meandering spiral waves, and spiral wave break-up may have distinct electrogram manifestations on a mapping catheter. Hence, it is desirable to have an automated classification of spiral wave behavior based on catheter recordings for a qualitative characterization of spatiotemporal electrophysiological activity on atrial tissue. In this study, we propose a method for classification of spatiotemporal characteristics of simulated atrial activation patterns in terms of distinct spiral wave behaviors during Afib using two different techniques: normalized compressed distance (NCD) and normalized FFT (NFFTD). We use a phenomenological model for cardiac electrical propagation to produce various simulated spiral wave behaviors on a 2D grid and labeled them as stable, meandering, or breakup. By mimicking commonly used catheter types, a star shaped and a circular shaped both of which do the local readings from atrial wall, monopolar and bipolar intracardiac electrograms are simulated. Virtual catheters are positioned at different locations on the grid. The classification performance for different catheter locations, types and for monopolar or bipolar readings were also compared. We observed that the performance for each case differed slightly. However, we found that NCD performance is superior to NFFTD. Through the simulation study, we showed the theoretical validation of the proposed method. Our findings suggest that a qualitative wavefront activation pattern can be assessed during Afib without the need for highly invasive mapping techniques such as multisite simultaneous electrogram recordings.

Comparative numerical and experimental study of two combined wind and wave energy concepts

Directory of Open Access Journals (Sweden)

Zhen Gao

2016-01-01

Full Text Available With a successful and rapid development of offshore wind industry and increased research activities on wave energy conversion in recent years, there is an interest in investigating the technological and economic feasibility of combining offshore wind turbines (WTs with wave energy converters (WECs. In the EU FP7 MARINA Platform project, three floating combined concepts, namely the spar torus combination (STC, the semi-submersible flap combination (SFC and the oscillating water column (OWC array with a wind turbine, were selected and studied in detail by numerical and experimental methods. This paper summarizes the numerical modeling and analysis of the two concepts: STC and SFC, the model tests at a 1:50 scale under simultaneous wave and wind excitation, as well as the comparison between the numerical and experimental results. Both operational and survival wind and wave conditions were considered. The numerical analysis was based on a time-domain global model using potential flow theory for hydrodynamics and blade element momentum theory (for SFC or simplified thrust force model (for STC for aerodynamics. Different techniques for model testing of combined wind and wave concepts were discussed with focus on modeling of wind turbines by disk or redesigned small-scale rotor and modeling of power take-off (PTO system for wave energy conversion by pneumatic damper or hydraulic rotary damper. In order to reduce the uncertainty due to scaling, the numerical analysis was performed at model scale and both the numerical and experimental results were then up-scaled to full scale for comparison. The comparison shows that the current numerical model can well predict the responses (motions, PTO forces, power production of the combined concepts for most of the cases. However, the linear hydrodynamic model is not adequate for the STC concept in extreme wave conditions with the torus fixed to the spar at the mean water level for which the wave slamming on the

Angular Spectrum Simulation of Pulsed Ultrasound Fields

DEFF Research Database (Denmark)

Du, Yigang; Jensen, Henrik; Jensen, Jørgen Arendt

2009-01-01

frequencies must be performed. Combining it with Field II, the generation of non-linear simulation for any geometry with any excitation array transducer becomes feasible. The purpose of this paper is to make a general pulsed simulation software using the modified ASA. Linear and phased array transducers......The optimization of non-linear ultrasound imaging should in a first step be based on simulation, as this makes parameter studies considerably easier than making transducer prototypes. Such a simulation program should be capable of simulating non-linear pulsed fields for arbitrary transducer...... geometries for any kind of focusing and apodization. The Angular Spectrum Approach (ASA) is capable of simulating monochromatic non-linear acoustic wave propagation. However, for ultrasound imaging the time response of each specific point in space is required, and a pulsed ASA simulation with multi temporal...

[Low-frequency pulsed magnetotherapy combined with electrostimulation of biologically active points in the combined treatment of traumatic mandibular osteomyelitis].

Science.gov (United States)

Korotkikh, N G; Oreshkin, A V

1999-01-01

The results of treatment are analyzed in 51 patients (35 with exacerbation of chronic traumatic mandibular osteomyelitis and 16 with chronic traumatic mandibular osteomyelitis). Low-intensity pulsed magnetic therapy of the focus in combination with electric stimulation of segmentary bioactive points, synchronized by the patient's pulse, are proposed to be added to the therapeutic complex. Such a modality improved the regional hemodynamics, promoted liquidation of the postoperative edema on days 1-2 after intervention, and sooner than after traditional therapy repaired the energy of the patient's organism.

Atmospheric pressure plasma jets interacting with liquid covered tissue: touching and not-touching the liquid

International Nuclear Information System (INIS)

Norberg, Seth A; Johnsen, Eric; Tian, Wei; Kushner, Mark J

2014-01-01

In the use of atmospheric pressure plasma jets in biological applications, the plasma-produced charged and neutral species in the plume of the jet often interact with a thin layer of liquid covering the tissue being treated. The plasma-produced reactivity must then penetrate through the liquid layer to reach the tissue. In this computational investigation, a plasma jet created by a single discharge pulse at three different voltages was directed onto a 200 µm water layer covering tissue followed by a 10 s afterglow. The magnitude of the voltage and its pulse length determined if the ionization wave producing the plasma plume reached the surface of the liquid. When the ionization wave touches the surface, significantly more charged species were created in the water layer with H 3 O + aq , O 3 − aq , and O 2 − aq being the dominant terminal species. More aqueous OH aq , H 2 O 2aq , and O 3aq were also formed when the plasma plume touches the surface. The single pulse examined here corresponds to a low repetition rate plasma jet where reactive species would be blown out of the volume between pulses and there is not recirculation of flow or turbulence. For these conditions, N x O y species do not accumulate in the volume. As a result, aqueous nitrites, nitrates, and peroxynitrite, and the HNO 3aq and HOONO aq , which trace their origin to solvated N x O y , have low densities. (paper)

Arterial blood pressure measurement and pulse wave analysis—their role in enhancing cardiovascular assessment

International Nuclear Information System (INIS)

Avolio, Alberto P; Butlin, Mark; Walsh, Andrew

2010-01-01

The most common method of clinical measurement of arterial blood pressure is by means of the cuff sphygmomanometer. This instrument has provided fundamental quantitative information on arterial pressure in individual subjects and in populations and facilitated estimation of cardiovascular risk related to levels of blood pressure obtained from the brachial cuff. Although the measurement is taken in a peripheral limb, the values are generally assumed to reflect the pressure throughout the arterial tree in large conduit arteries. Since the arterial pressure pulse becomes modified as it travels away from the heart towards the periphery, this is generally true for mean and diastolic pressure, but not for systolic pressure, and so pulse pressure. The relationship between central and peripheral pulse pressure depends on propagation characteristics of arteries. Hence, while the sphygmomanometer gives values of two single points on the pressure wave (systolic and diastolic pressure), there is additional information that can be obtained from the time-varying pulse waveform that enables an improved quantification of the systolic load on the heart and other central organs. This topical review will assess techniques of pressure measurement that relate to the use of the cuff sphygmomanometer and to the non-invasive registration and analysis of the peripheral and central arterial pressure waveform. Improved assessment of cardiovascular function in relation to treatment and management of high blood pressure will result from future developments in the indirect measurement of arterial blood pressure that involve the conventional cuff sphygmomanometer with the addition of information derived from the peripheral arterial pulse. (topical review)

Development of a Cardiovascular Simulator for Studying Pulse Diagnosis Mechanisms

Directory of Open Access Journals (Sweden)

Min Jang

2017-01-01

Full Text Available This research was undertaken to develop a cardiovascular simulator for use in the study of pulse diagnosis. The physical (i.e., pulse wave transmission and reflection and physiological (i.e., systolic and diastolic pressure, pulse pressure, and mean pressure characteristics of the radial pulse wave were reproduced by our simulator. The simulator consisted of an arterial component and a pulse-generating component. Computer simulation was used to simplify the arterial component while maintaining the elastic modulus and artery size. To improve the reflected wave characteristics, a palmar arch was incorporated within the simulator. The simulated radial pulse showed good agreement with clinical data.

Effects of a physiological GH pulse on interstitial glycerol in abdominal and femoral adipose tissue

DEFF Research Database (Denmark)

Gravhølt, C H; Schmitz, Ole; Simonsen, L

1999-01-01

.0005). Administration of GH induced an increase in interstitial glycerol in both abdominal and femoral adipose tissue (ANOVA: abdominal, P = 0. 04; femoral, P = 0.03). There was no overall difference in the response to GH in the two regions during the study period as a whole (ANOVA: P = 0.5), but during peak...... stimulation of lipolysis abdominal adipose tissue was, in absolute but not in relative terms, stimulated more markedly than femoral adipose tissue (ANOVA: P = 0. 03 from 45 to 225 min). Peak interstitial glycerol values of 253 +/- 37 and 336 +/- 74 micromol/l were seen after 135 and 165 min in femoral...... and abdominal adipose tissue, respectively. ATBF was not statistically different in the two situations (ANOVA: P = 0.7). In conclusion, we have shown that a physiological pulse of GH increases interstitial glycerol concentrations in both femoral and abdominal adipose tissue, indicating activated lipolysis...

Combination of biochemical and mechanical cues for tendon tissue engineering.

Science.gov (United States)

Testa, Stefano; Costantini, Marco; Fornetti, Ersilia; Bernardini, Sergio; Trombetta, Marcella; Seliktar, Dror; Cannata, Stefano; Rainer, Alberto; Gargioli, Cesare

2017-11-01

Tendinopathies negatively affect the life quality of millions of people in occupational and athletic settings, as well as the general population. Tendon healing is a slow process, often with insufficient results to restore complete endurance and functionality of the tissue. Tissue engineering, using tendon progenitors, artificial matrices and bioreactors for mechanical stimulation, could be an important approach for treating rips, fraying and tissue rupture. In our work, C3H10T1/2 murine fibroblast cell line was exposed to a combination of stimuli: a biochemical stimulus provided by Transforming Growth Factor Beta (TGF-β) and Ascorbic Acid (AA); a three-dimensional environment represented by PEGylated-Fibrinogen (PEG-Fibrinogen) biomimetic matrix; and a mechanical induction exploiting a custom bioreactor applying uniaxial stretching. In vitro analyses by immunofluorescence and mechanical testing revealed that the proposed combined approach favours the organization of a three-dimensional tissue-like structure promoting a remarkable arrangement of the cells and the neo-extracellular matrix, reflecting into enhanced mechanical strength. The proposed method represents a novel approach for tendon tissue engineering, demonstrating how the combined effect of biochemical and mechanical stimuli ameliorates biological and mechanical properties of the artificial tissue compared to those obtained with single inducement. © 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

Energetic mid-IR femtosecond pulse generation by self-defocusing soliton-induced dispersive waves in a bulk quadratic nonlinear crystal

DEFF Research Database (Denmark)

Zhou, Binbin; Guo, Hairun; Bache, Morten

2015-01-01

Generating energetic femtosecond mid-IR pulses is crucial for ultrafast spectroscopy, and currently relies on parametric processes that, while efficient, are also complex. Here we experimentally show a simple alternative that uses a single pump wavelength without any pump synchronization and with...... by using large-aperture crystals. The technique can readily be implemented with other crystals and laser wavelengths, and can therefore potentially replace current ultrafast frequency-conversion processes to the mid-IR....... and without critical phase-matching requirements. Pumping a bulk quadratic nonlinear crystal (unpoled LiNbO3 cut for noncritical phase-mismatched interaction) with sub-mJ near-IR 50-fs pulses, tunable and broadband (∼ 1,000 cm−1) mid-IR pulses around 3.0 μm are generated with excellent spatio-temporal pulse...... quality, having up to 10.5 μJ energy (6.3% conversion). The mid-IR pulses are dispersive waves phase-matched to near-IR self-defocusing solitons created by the induced self-defocusing cascaded nonlinearity. This process is filament-free and the input pulse energy can therefore be scaled arbitrarily...

Acoustic pressure waves induced in human heads by RF pulses from high-field MRI scanners.

Science.gov (United States)

Lin, James C; Wang, Zhangwei

2010-04-01

The current evolution toward greater image resolution from magnetic resonance image (MRI) scanners has prompted the exploration of higher strength magnetic fields and use of higher levels of radio frequencies (RFs). Auditory perception of RF pulses by humans has been reported during MRI with head coils. It has shown that the mechanism of interaction for the auditory effect is caused by an RF pulse-induced thermoelastic pressure wave inside the head. We report a computational study of the intensity and frequency of thermoelastic pressure waves generated by RF pulses in the human head inside high-field MRI and clinical scanners. The U.S. Food and Drug Administration (U.S. FDA) guides limit the local specific absorption rate (SAR) in the body-including the head-to 8 W kg(-1). We present results as functions of SAR and show that for a given SAR the peak acoustic pressures generated in the anatomic head model were essentially the same at 64, 300, and 400 MHz (1.5, 7.0, and 9.4 T). Pressures generated in the anatomic head are comparable to the threshold pressure of 20 mPa for sound perception by humans at the cochlea for 4 W kg(-1). Moreover, results indicate that the peak acoustic pressure in the brain is only 2 to 3 times the auditory threshold at the U.S. FDA guideline of 8 W kg(-1). Even at a high SAR of 20 W kg(-1), where the acoustic pressure in the brain could be more than 7 times the auditory threshold, the sound pressure levels would not be more than 17 db above threshold of perception at the cochlea.

Attosecond electron wave packet interferometry

International Nuclear Information System (INIS)

Remetter, T.; Ruchon, T.; Johnsson, P.; Varju, K.; Gustafsson, E.

2006-01-01

Complete test of publication follows. The well controlled generation and characterization of attosecond XUV light pulses provide an unprecedented tool to study electron wave packets (EWPs). Here a train of attosecond pulses is used to create and study the phase of an EWP in momentum space. There is a clear analogy between electronic wave functions and optical fields. In optics, methods like SPIDER or wave front shearing interferometry, allow to measure the spectral or spatial phase of a light wave. These two methods are based on the same principle: an interferogram is produced when recombining two sheared replica of a light pulse, spectrally (SPIDER) or spatially (wave front shearing interferometry). This enables the comparison of two neighbouring different spectral or spatial slices of the original wave packet. In the experiment, a train of attosecond pulses is focused in an Argon atomic gas jet. EWPs are produced from the single XUV photon ionization of Argon atoms. If an IR beam is synchronized to the EWPs, it is possible to introduce a shear in momentum space between two consecutive s wave packets. A Velocity Map Imaging Spectrometer (VMIS) enables us to detect the interference pattern. An analysis of the interferograms will be presented leading to a conclusion about the symmetry of the studied wave packet.

PASSIVE CAVITATION DETECTION DURING PULSED HIFU EXPOSURES OF EX VIVO TISSUES AND IN VIVO MOUSE PANCREATIC TUMORS

OpenAIRE

Li, Tong; Chen, Hong; Khokhlova, Tatiana; Wang, Yak-Nam; Kreider, Wayne; He, Xuemei; Hwang, Joo Ha

2014-01-01

Pulsed high-intensity focused ultrasound (pHIFU) has been demonstrated to enhance vascular permeability, disrupt tumor barriers and enhance drug penetration into tumor tissue through acoustic cavitation. Monitoring of cavitation activity during pHIFU treatments and knowing the ultrasound pressure levels sufficient to reliably induce cavitation in a given tissue are therefore very important. Here, three metrics of cavitation activity induced by pHIFU and evaluated by confocal passive cavitatio...

The effective reflection of a pulse sequence from a four-wave mirror with thermal nonlinearity under parametric feedback

Science.gov (United States)

Barashkov, M. S.; Bel'Diugin, I. M.; Zolotarev, M. V.; Kruzhilin, Iu. I.; Krymskii, M. I.

1989-04-01

A four-wave mirror with thermal nonlinearity has been experimentally realized with the interaction of corunning waves under parametric feedback with a nonreciprocal element. The effective reflection of a sequence of pulses with duration of about 300 ns from a neodymium-glass laser with maximal reflection coefficients greater than 30 has been demonstrated. The quality of the radiation reflected from the mirror is studied. A significant reduction in the steady-state lasing threshold has been shown with thermal nonlinearity at small angles of the interacting beam convergence, compared to the case of counterrunning convergence.

Ionospheric cusp flows pulsed by solar wind Alfvén waves

Directory of Open Access Journals (Sweden)

P. Prikryl

2002-02-01

Full Text Available Pulsed ionospheric flows (PIFs in the cusp foot-print have been observed by the SuperDARN radars with periods between a few minutes and several tens of minutes. PIFs are believed to be a consequence of the interplanetary magnetic field (IMF reconnection with the magnetospheric magnetic field on the dayside magnetopause, ionospheric signatures of flux transfer events (FTEs. The quasiperiodic PIFs are correlated with Alfvénic fluctuations observed in the upstream solar wind. It is concluded that on these occasions, the FTEs were driven by Alfvén waves coupling to the day-side magnetosphere. Case studies are presented in which the dawn-dusk component of the Alfvén wave electric field modulates the reconnection rate as evidenced by the radar observations of the ionospheric cusp flows. The arrival of the IMF southward turning at the magnetopause is determined from multipoint solar wind magnetic field and/or plasma measurements, assuming plane phase fronts in solar wind. The cross-correlation lag between the solar wind data and ground magnetograms that were obtained near the cusp footprint exceeded the estimated spacecraft-to-magnetopause propagation time by up to several minutes. The difference can account for and/or exceeds the Alfvén propagation time between the magnetopause and ionosphere. For the case of short period ( < 13 min PIFs, the onset times of the flow transients appear to be further delayed by at most a few more minutes after the IMF southward turning arrived at the magnetopause. For the case of long period (30 – 40 min PIFs, the observed additional delays were 10–20 min. We interpret the excess delay in terms of an intrinsic time scale for reconnection (Russell et al., 1997 which can be explained by the surface-wave induced magnetic reconnection mechanism (Uberoi et al., 1999. Here, surface waves with wavelengths larger than the thickness of the neutral layer induce a tearing-mode instability whose rise time explains the

Detection and Characterization of Flaws in Sprayed on Foam Insulation with Pulsed Terahertz Frequency Electromagnetic Waves

Science.gov (United States)

Winfree, William P.; Madaras, Eric I.

2005-01-01

The detection and repair of flaws such as voids and delaminations in the sprayed on foam insulation of the external tank reduces the probability of foam debris during shuttle ascent. The low density of sprayed on foam insulation along with it other physical properties makes detection of flaws difficult with conventional techniques. An emerging technology that has application for quantitative evaluation of flaws in the foam is pulsed electromagnetic waves at terahertz frequencies. The short wavelengths of these terahertz pulses make them ideal for imaging flaws in the foam. This paper examines the application of terahertz pulses for flaw detection in foam characteristic of the foam insulation of the external tank. Of particular interest is the detection of voids and delaminations, encapsulated in the foam or at the interface between the foam and a metal backing. The technique is shown to be capable of imaging small voids and delaminations through as much as 20 cm of foam. Methods for reducing the temporal responses of the terahertz pulses to improve flaw detection and yield quantitative characterizations of the size and location of the flaws are discussed.

Experimental study of the effect of Nd:YAG laser on dental hard tissues: comparison between multi-pulse and free-generation emission code

International Nuclear Information System (INIS)

Carballosa Amor, A.; Tellez Jimenez, H.; Ponce Flores, E.; Flores Reyes, T.

2016-01-01

The aim of this study is to compare and contrast the morphological changes on dental hard tissue when irradiated with a Nd: YAG laser both on multi-pulse mode, with a Q: Switch of Cr: YAG passive, and on free generation mode. The experimental sample consisted of 6 healthy third molars which were divided equally and randomly between the two emission methods. The depths of each perforation were measured by optical coherence tomography (OCT). It was noted that, despite being less energy in the multi-pulse mode, the first three shots in this achieved deeper cavities than the ones on the free generation mode. Also, less damage to surrounding tissue were obtained on multi-pulse mode. (Author)

Third order harmonic imaging for biological tissues using three phase-coded pulses.

Science.gov (United States)

Ma, Qingyu; Gong, Xiufen; Zhang, Dong

2006-12-22

Compared to the fundamental and the second harmonic imaging, the third harmonic imaging shows significant improvements in image quality due to the better resolution, but it is degraded by the lower sound pressure and signal-to-noise ratio (SNR). In this study, a phase-coded pulse technique is proposed to selectively enhance the sound pressure of the third harmonic by 9.5 dB whereas the fundamental and the second harmonic components are efficiently suppressed and SNR is also increased by 4.7 dB. Based on the solution of the KZK nonlinear equation, the axial and lateral beam profiles of harmonics radiated from a planar piston transducer were theoretically simulated and experimentally examined. Finally, the third harmonic images using this technique were performed for several biological tissues and compared with the images obtained by the fundamental and the second harmonic imaging. Results demonstrate that the phase-coded pulse technique yields a dramatically cleaner and sharper contrast image.

Pulse frequency dependency of photobiomodulation on the bioenergetic functions of human dental pulp stem cells.

Science.gov (United States)

Kim, Hong Bae; Baik, Ku Youn; Choung, Pill-Hoon; Chung, Jong Hoon

2017-11-21

Photobiomodulation (PBM) therapy contributes to pain relief, wound healing, and tissue regeneration. The pulsed wave (PW) mode has been reported to be more effective than the continuous wave (CW) mode when applying PBM to many biological systems. However, the reason for the higher effectiveness of PW-PBM is poorly understood. Herein, we suggest using delayed luminescence (DL) as a reporter of mitochondrial activity after PBM treatment. DL originates mainly from mitochondrial electron transport chain systems, which produce reactive oxygen species (ROS) and adenosine triphosphate (ATP). The decay time of DL depends on the pulse frequencies of applied light, which correlate with the biological responses of human dental pulp stem cells (hDPSCs). Using a low-power light whose wavelength is 810 nm and energy density is 38 mJ/cm 2 , we find that a 300-Hz pulse frequency prolonged the DL pattern and enhanced alkaline phosphatase activity. In addition, we analyze mitochondrial morphological changes and their volume density and find evidence supporting mitochondrial physiological changes from PBM treatment. Our data suggest a new methodology for determining the effectiveness of PBM and the specific pulse frequency dependency of PBM in the differentiation of hDPSCs.

Dispersion - does it degrade a pulse envelope

International Nuclear Information System (INIS)

Deighton, M.O.

1985-01-01

In hostile environments, transmitting information as ultrasonic Lamb wave pulses has advantages, since the stainless steel strip serving as a waveguide is very durable. Besides attenuation, velocity dispersion (inherent in Lamb waves) can be important even in fairly short guides. Theory shows that unlimited propagation of a pulsed r.f. envelope is possible, even with dispersion present. The constant group velocity needed would favour asub(o)-mode pulses over other modes, provided ordinary attenuation is small. An approximate formula indicates the useful range of a pulse, when group velocity does vary. (author)

Effect of heat-induced pain stimuli on pulse transit time and pulse wave amplitude in healthy volunteers.

Science.gov (United States)

van Velzen, Marit H N; Loeve, Arjo J; Kortekaas, Minke C; Niehof, Sjoerd P; Mik, Egbert G; Stolker, Robert J

2016-01-01

Pain is commonly assessed subjectively by interpretations of patient behaviour and/or reports from patients. When this is impossible the availability of a quantitative objective pain assessment tool based on objective physiological parameters would greatly benefit clinical practice and research beside the standard self-report tests. Vasoconstriction is one of the physiological responses to pain. The aim of this study was to investigate whether pulse transit time (PTT) and pulse wave amplitude (PWA) decrease in response to this vasoconstriction when caused by heat-induced pain. The PTT and PWA were measured in healthy volunteers, on both index fingers using photoplethysmography and electrocardiography. Each subject received 3 heat-induced pain stimuli using a Temperature-Sensory Analyzer thermode block to apply a controlled, increasing temperature from 32.0 °C to 50.0 °C to the skin. After reaching 50.0 °C, the thermode was immediately cooled down to 32.0 °C. The study population was divided into 2 groups with a time-interval between the stimuli 20s or 60s. The results showed a significant (p  Heat-induced pain causes a decrease of PTT and PWA. Consequently, it is expected that, in the future, PTT and PWA may be applied as objective indicators of pain, either beside the standard self-report test, or when self-report testing is impossible.

Accuracy of real-time shear wave elastography in the assessment of normal liver tissue in the guinea pig (cavia porcellus).

Science.gov (United States)

Glińska-Suchocka, K; Kubiak, K; Spużak, J; Jankowski, M; Borusewicz, P

2017-03-28

Shear wave elastography is a novel technique enabling real-time measurement of the elasticity of liver tissue. The color map is superimposed on the classic ultrasound image of the assessed tissue, which enables a precise evaluation of the stiffness of the liver tissue. The aim of the study was to assess the stiffness of normal liver tissue in the guinea pig using shear wave elastography. The study was carried out on 36 guinea pigs using the SuperSonic Imagine Aixplorer scanner, and a 1 to 6 MH convex SC6-1 transducer. An ultrasound guided Try-Cut liver core needle biopsy was carried out in all the studied animals and the collected samples were examined to exclude pathological lesions. The mean liver tissue stiffness ranged from 0.89 to 5.40 kPa. We found that shear wave elastography is an easy, non-invasive technique that can be used to assess the stiffness of liver tissue. The obtained results can be used in future studies to assess the types and changes of liver tissue in the course of various types of liver disease.

The association between pulse wave velocity and cognitive function: the Sydney Memory and Ageing Study.

Directory of Open Access Journals (Sweden)

Joel Singer

Full Text Available OBJECTIVES: Pulse wave velocity (PWV is a measure of arterial stiffness and its increase with ageing has been associated with damage to cerebral microvessels and cognitive impairment. This study examined the relationship between carotid-femoral PWV and specific domains of cognitive function in a non-demented elderly sample. METHOD: Data were drawn from the Sydney Memory and Ageing Study, a cohort study of non-demented community-dwelling individuals aged 70-90 years, assessed in successive waves two years apart. In Wave 2, PWV and cognitive function were measured in 319 participants. Linear regression was used to analyse the cross-sectional relationship between arterial stiffness and cognitive function in the whole sample, and separately for men and women. Analysis of covariance was used to assess potential differences in cognition between subjects with PWV measurements in the top and bottom tertiles of the cohort. Covariates were age, education, body mass index, pulse rate, systolic blood pressure, cholesterol, depression, alcohol, smoking, hormone replacement therapy, apolipoprotein E ε4 genotype, use of anti-hypertensive medications, history of stroke, transient ischemic attack, myocardial infarction, angina, diabetes, and also sex for the whole sample analyses. RESULTS: There was no association between PWV and cognition after Bonferroni correction for multiple testing. When examining this association for males and females separately, an association was found in males, with higher PWV being associated with lower global cognition and memory, however, a significant difference between PWV and cognition between males and females was not found. CONCLUSION: A higher level of PWV was not associated with lower cognitive function in the whole sample.

Discrimination of soft tissues using laser-induced breakdown spectroscopy in combination with k nearest neighbors (kNN) and support vector machine (SVM) classifiers

Science.gov (United States)

Li, Xiaohui; Yang, Sibo; Fan, Rongwei; Yu, Xin; Chen, Deying

2018-06-01

In this paper, discrimination of soft tissues using laser-induced breakdown spectroscopy (LIBS) in combination with multivariate statistical methods is presented. Fresh pork fat, skin, ham, loin and tenderloin muscle tissues are manually cut into slices and ablated using a 1064 nm pulsed Nd:YAG laser. Discrimination analyses between fat, skin and muscle tissues, and further between highly similar ham, loin and tenderloin muscle tissues, are performed based on the LIBS spectra in combination with multivariate statistical methods, including principal component analysis (PCA), k nearest neighbors (kNN) classification, and support vector machine (SVM) classification. Performances of the discrimination models, including accuracy, sensitivity and specificity, are evaluated using 10-fold cross validation. The classification models are optimized to achieve best discrimination performances. The fat, skin and muscle tissues can be definitely discriminated using both kNN and SVM classifiers, with accuracy of over 99.83%, sensitivity of over 0.995 and specificity of over 0.998. The highly similar ham, loin and tenderloin muscle tissues can also be discriminated with acceptable performances. The best performances are achieved with SVM classifier using Gaussian kernel function, with accuracy of 76.84%, sensitivity of over 0.742 and specificity of over 0.869. The results show that the LIBS technique assisted with multivariate statistical methods could be a powerful tool for online discrimination of soft tissues, even for tissues of high similarity, such as muscles from different parts of the animal body. This technique could be used for discrimination of tissues suffering minor clinical changes, thus may advance the diagnosis of early lesions and abnormalities.

Photon statistics of pulse-pumped four-wave mixing in fiber with weak signal injection

Science.gov (United States)

Nan-Nan, Liu; Yu-Hong, Liu; Jia-Min, Li; Xiao-Ying, Li

2016-07-01

We study the photon statistics of pulse-pumped four-wave mixing in fibers with weak coherent signal injection by measuring the intensity correlation functions of individual signal and idler fields. The experimental results show that the intensity correlation function of individual signal (idler) field decreases with the intensity of signal injection. After applying narrow band filter in signal (idler) band, the value of decreases from 1.9 ± 0.02 (1.9 ± 0.02) to 1.03 ± 0.02 (1.05 ± 0.02) when the intensity of signal injection varies from 0 to 120 photons/pulse. The results indicate that the photon statistics changes from Bose-Einstein distribution to Poisson distribution. We calculate the intensity correlation functions by using the multi-mode theory of four-wave mixing in fibers. The theoretical curves well fit the experimental results. Our investigation will be useful for mitigating the crosstalk between quantum and classical channels in a dense wavelength division multiplexing network. Project supported by the National Natural Science Foundation of China (Grant No. 11527808), the State Key Development Program for Basic Research of China (Grant No. 2014CB340103), the Specialized Research Fund for the Doctoral Program of Higher Education of China (Grant No. 20120032110055), the Natural Science Foundation of Tianjin, China (Grant No. 14JCQNJC02300), the Program for Changjiang Scholars and Innovative Research Team in University, China, and the Program of Introducing Talents of Discipline to Universities, China (Grant No. B07014).

The effect of high-frequency electrical pulses on organic tissue in root canals.

Science.gov (United States)

Lendini, M; Alemanno, E; Migliaretti, G; Berutti, E

2005-08-01

To evaluate debris and smear layer scores after application of high-frequency electrical pulses produced by the Endox Endodontic System (Lysis Srl, Nova Milanese, Italy) on intact pulp tissue and organic and inorganic residues after endodontic instrumentation. The study comprised 75 teeth planned for extraction. The teeth were randomly divided into two groups (60 teeth) and a control group (15 teeth): group 1 (30 teeth) was not subjected to instrumentation; group 2 (30 teeth) was instrumented by Hero Shaper instruments and apical stops were prepared to size 40. Each group was subdivided into subgroups A and B (15 teeth); two electrical pulses were applied to subgroups 1A and 2A (one in the apical third and one in the middle third, respectively, at 3 and 6 mm from the root apices); four electrical pulses were applied to subgroups 1B and 2B (two in the apical third, two in the middle third). The control group (15 teeth) was prepared with Hero Shapers and irrigated with 5 mL of EDTA (10%) and 5 mL of 5% NaOCl at 50 degrees C but not subjected to the electrical pulse treatment. Roots were split longitudinally and canal walls were examined at 80x, 200x, 750x, 1500x and 15,000x magnifications, using a scanning electron microscope. Smear layer and debris scores were recorded at the 3 and 6 mm levels using a five-step scoring scale and a 200-microm grid. Means were tested for significance using the one-way anova model and the Bonferroni post-hoc test. The differences between groups were considered to be statistically significant when P < 0.05. The mean value for debris scores for the three groups varied from 1.80 (+/-0.77) to 4.50 (+/-0.68). The smear layer scores for group 2 and the control specimens varied from 2.00 (+/-0.91) to 2.33 (+/-0.99). A significant difference was found in mean debris scores at the 3 and 6 mm levels between the three groups (P < 0.001). The Bonferroni post-hoc test confirmed that the difference was due to group 1. In the two subgroups treated

New 445 nm blue laser for laryngeal surgery combines photoangiolytic and cutting properties.

Science.gov (United States)

Hess, Markus M; Fleischer, Susanne; Ernstberger, Marcel

2018-06-01

Photoangiolytic lasers have broadened the surgical armamentarium for many phonosurgical interventions. However, the pulse dye laser and potassium titanyl phosphate (KTP) laser have technical drawbacks and a smaller spectrum of indications. The new 445 nm wavelength laser, the so-called 'blue laser', proves to show tissue effects comparable to the KTP laser and is also capable of treating subepithelial vessels due to its photoangiolytic properties, it can coagulate and carbonize at higher energy levels, and can be used via glass fibers in non-contact and contact mode for in-office procedures. In contrast to the KTP, the new 445 nm laser can also be used as a cutting laser, thus combining very much wanted properties of diode or CO2 lasers with photoangiolytic lasers. Further advantages of the new laser are the; (1) portability of the shoe box sized, shock-proof laser machine for in-office and operating room usage, (2) the selection of pulse rates from continuous wave (cw) to less than a millisecond, (3) stronger tissue effects compared to KTP with similar energy and pulse settings, (4) far better cutting properties than the KTP, and thus (5) more possibilities for usage in laryngology as well as in other fields or surgery. We demonstrate the feasibility of the 445 nm laser in several laboratory experiments and show clinical cases where photoangiolysis and cutting was possible. However, this is a preliminary report and further systematic studies in greater numbers are warranted.

Radiation chemistry and advanced polymer materials studied by picosecond pulse radiolysis combined with femtosecond laser

International Nuclear Information System (INIS)

Tagawa, S.; Yoshida, Y.; Miki, M.; Yamamoto, T.; Ushida, K.; Izumi, Y.

1996-01-01

We have synchronized a single picosecond MeV electron pulse from L-band linear accelerator (linac) of The Institute of Scientific and Industrial Research of Osaka University to a single femtosecond laser pulse of Ti:Sapphire laser. It is an essential technique for the future femtosecond pulse radiolysis and is also applied to many kinds of combined application of more than two different beams from accelerators in very short time range. Radiation chemistry and new type of polymers have been studied by LL (laser-linac) twin picosecond pulse radiolysis. Especially the early events in radiation chemistry such as geminate recombination processes of electrons and radical cations are have been studied in both liquids and solids. (author)

Electromagnetic or other directed energy pulse launcher

Science.gov (United States)

Ziolkowski, Richard W.

1990-01-01

The physical realization of new solutions of wave propagation equations, such as Maxwell's equations and the scaler wave equation, produces localized pulses of wave energy such as electromagnetic or acoustic energy which propagate over long distances without divergence. The pulses are produced by driving each element of an array of radiating sources with a particular drive function so that the resultant localized packet of energy closely approximates the exact solutions and behaves the same.

Two-dimensional Shear Wave Elastography on Conventional Ultrasound Scanners with Time Aligned Sequential Tracking (TAST) and Comb-push Ultrasound Shear Elastography (CUSE)

OpenAIRE

Song, Pengfei; Macdonald, Michael C.; Behler, Russell H.; Lanning, Justin D.; Wang, Michael H.; Urban, Matthew W.; Manduca, Armando; Zhao, Heng; Callstrom, Matthew R.; Alizad, Azra; Greenleaf, James F.; Chen, Shigao

2015-01-01

Two-dimensional (2D) shear wave elastography presents 2D quantitative shear elasticity maps of tissue, which are clinically useful for both focal lesion detection and diffuse disease diagnosis. Realization of 2D shear wave elastography on conventional ultrasound scanners, however, is challenging due to the low tracking pulse-repetition-frequency (PRF) of these systems. While some clinical and research platforms support software beamforming and plane wave imaging with high PRF, the majority of...

A new coding concept for fast ultrasound imaging using pulse trains

DEFF Research Database (Denmark)

Misaridis, T.; Jensen, Jørgen Arendt

2002-01-01

Frame rate in ultrasound imaging can he increased by simultaneous transmission of multiple beams using coded waveforms. However, the achievable degree of orthogonality among coded waveforms is limited in ultrasound, and the image quality degrades unacceptably due to interbeam interference....... In this paper, an alternative combined time-space coding approach is undertaken. In the new method all transducer elements are excited with short pulses and the high time-bandwidth (TB) product waveforms are generated acoustically. Each element transmits a short pulse spherical wave with a constant transmit...... delay from element to element, long enough to assure no pulse overlapping for all depths in the image. Frequency shift keying is used for "per element" coding. The received signals from a point scatterer are staggered pulse trains which are beamformed for all beam directions and further processed...

Shock Wave Propagation in Functionally Graded Mineralized Tissue

Science.gov (United States)

Nelms, Matthew; Hodo, Wayne; Livi, Ken; Browning, Alyssa; Crawford, Bryan; Rajendran, A. M.

2017-06-01

In this investigation, the effects of shock wave propagation in bone-like biomineralized tissue was investigated. The Alligator gar (Atractosteus spatula) exoskeleton is comprised of many disparate scales that provide a biological analog for potential design of flexible protective material systems. The gar scale is identified as a two-phase, (1) hydroxyapatite mineral and (2) collagen protein, biological composite with two distinct layers where a stiff, ceramic-like ganoine overlays a soft, highly ductile ganoid bone. Previous experimentations has shown significant softening under compressive loading and an asymmetrical stress-strain response for analogous mineralized tissues. The structural features, porosity, and elastic modulus were determined from high-resolution scanning electron microscopy, 3D micro-tomography, and dynamic nanoindentation experiments to develop an idealized computational model for FE simulations. The numerical analysis employed Gurson's yield criterion to determine the influence of porosity and pressure on material strength. Functional gradation of elastic moduli and certain structural features, such as the sawtooth interface, are explicitly modeled to study the plate impact shock profile for a full 3-D analysis using ABAQUS finite element software.

Radiation and propagation of short acoustical pulses from underground explosions

International Nuclear Information System (INIS)

Banister, J.R.

1982-06-01

Radiation and propagation of short acoustical pulses from underground nuclear explosions were analyzed. The cone of more intense radiation is defined by the ratio of sound speeds in the ground and air. The pressure history of the radiated pulse is a function of the vertical ground-motion history, the range, the burial depth, and the velocity of longitudinal seismic waves. The analysis of short-pulse propagation employed an N-wave model with and without enegy conservation. Short pulses with initial wave lengths less than 100 m are severely attenuated by the energy loss in shocks and viscous losses in the wave interior. The methods developed in this study should be useful for system analysis

Angular momentum transport with twisted exciton wave packets

Science.gov (United States)

Zang, Xiaoning; Lusk, Mark T.

2017-10-01

A chain of cofacial molecules with CN or CN h symmetry supports excitonic states with a screwlike structure. These can be quantified with the combination of an axial wave number and an azimuthal winding number. Combinations of these states can be used to construct excitonic wave packets that spiral down the chain with well-determined linear and angular momenta. These twisted exciton wave packets can be created and annihilated using laser pulses, and their angular momentum can be optically modified during transit. This allows for the creation of optoexcitonic circuits in which information, encoded in the angular momentum of light, is converted into excitonic wave packets that can be manipulated, transported, and then reemitted. A tight-binding paradigm is used to demonstrate the key ideas. The approach is then extended to quantify the evolution of twisted exciton wave packets in a many-body, multilevel time-domain density functional theory setting. In both settings, numerical methods are developed that allow the site-to-site transfer of angular momentum to be quantified.

Spin effects in nonlinear Compton scattering in a plane-wave laser pulse

International Nuclear Information System (INIS)

Boca, Madalina; Dinu, Victor; Florescu, Viorica

2012-01-01

We study theoretically the electron angular and energy distribution in the non-linear Compton effect in a finite plane-wave laser pulse. We first present analytical and numerical results for unpolarized electrons (described by a Volkov solution of the Dirac equation), in comparison with those corresponding to a spinless particle (obeying the Klein–Gordon equation). Then, in the spin 1/2 case, we include results for the spin flip probability. The regime in which the spin effects are negligible, i.e. the results for the unpolarized spin 1/2 particle coincide practically with those for the spinless particle, is the same as the regime in which the emitted radiation is well described by classical electrodynamics.

Comparative Study on the Pulse Wave Variables and Sasang Constitution in Cerebral Infarction Patients and Healthy Subjects

Directory of Open Access Journals (Sweden)

Ko KiDuk

2007-06-01

Full Text Available This study was performed to determine whether a pulse analyzer was useful 1 to characterize the variables of pulse wave of cerebral infarction patieno (CI, compared with those of healthy subjects, as well as 2 to determine Sasang Constitution in CI and healthy subjects. 1. Calibrated in Gwan, the amount of energy(Energy, height of main peak(H1, height of aorticvalley(H2, height of aortic peak(H3, total area of pulse wave(At, and area of main peak width(Aw of the CI group were higher than those of the healthy group. 2. Calibrated in Cheek, Energy, H1, H2, H3, height of valve valley(H4, At, Aw, and main peak angle(MPA of the CI group were higher than those of the healthy group. 3. Among the healthy (subjects group, Taeumin showed the highest contact pressure(CP and height of valve peak(H5 calibrated in Chon. The main peak width divided by whole time of pulse wave(MPW/T calibrated in Gwan and Cheok, was highest in Soyangin and was lowest in Taeumin. The H3 divided by H1(H3/H1 and the time to valve valley minus the time to main peak and divided by T[(T4-T1/T] calibrated in Cheek were highest in Soyangin. The time to main peak(T1 was longest in Soumin. 4. Among the CI group, At calibrated in Chon was widest in Taeumin and was narrowest in Soumin The time to aortic peak(T3 calibrated in Cheek was longest in Soumin and was shortest in Soyangin. The time to valve peak(T5 was shortest in Soyangin. 5. There were main effects of cerebral infarction in the area of systolic period(As and area of diastolic period(Ad calibrated in Chon, Energy calibrated in Cwan, and Energy, H1, H2, H3, (H4+H5/Hl, and MPA calibrated in Cheek. 6. There were main effects of Sasang Constitution in (T4-T1/T, area of systolic period(As, and Ad calibrated in Chon. 7. The interactions between the cerebral infarction and Sasang Constitution were observed in H5/H1 , T, At, As, Ad, and MPA calibrated in Chon, H4, T4, (T4-T1/T, As, and Ad calibrated in Cwan, and 74,75, and MPW calibrated

Relations between diabetes, blood pressure and aortic pulse wave velocity in haemodialysis patients

DEFF Research Database (Denmark)

Peters, Christian Daugaard; Kjærgaard, Krista Dybtved; Dzeko, Mirela

(HD) and 32 HD patients with DM (HD+DM). The SphygmoCor system was used for estimation of PWV. HD-duration, age, gender and BP medication were similar in the two groups. Mean DM-duration was 23±11 years and 25(78%) had type 2 DM. HD+DM had higher BMI (26±5 vs. 29±5 kg/m2, p=0.02), systolic BP (142......Diabetes (DM) is common in haemodialysis (HD) patients and affects both blood pressure (BP) and arterial stiffness. Carotid femoral pulse wave velocity (PWV) reflects the stiffness of the aorta and is regarded as a strong risk factor for cardiovascular (CV) mortality in HD patients. However, PWV......±20 vs. 152±21 mmHg, p=0.02) and pulse pressure (65±17 vs. 80±18 mmHg, p2.5 in HD and 12.3±3.1 m/s in HD+DM. The mean PWV difference HD vs. HD+DM was 3.1(1.9-4.3)m/s, p

A Combined Tissue Kinetics and Dosimetric Model of Respiratory Tissue Exposed to Radiation

Energy Technology Data Exchange (ETDEWEB)

John R. Ford

2005-11-01

Existing dosimetric models of the radiation response of tissues are essentially static. Consideration of changes in the cell populations over time has not been addressed realistically. For a single acute dose this is not a concern, but for modeling chronic exposures or fractionated acute exposures, the natural turnover and progression of cells could have a significant impact on a variety of endpoints. This proposal addresses the shortcomings of current methods by combining current dose-based calculation techniques with information on the cell turnover for a model tissue. The proposed model will examine effects at the single-cell level for an exposure of a section of human bronchiole. The cell model will be combined with Monte Carlo calculations of doses to cells and cell nuclei due to varying dose-rates of different radiation qualities. Predictions from the model of effects on survival, apoptosis rates, and changes in the number of cycling and differentiating cells will be tested experimentally. The availability of dynamic dosimetric models of tissues at the single-cell level will be useful for analysis of low-level radiation exposures and in the development of new radiotherapy protocols.

Optoacoustic theranostics

Science.gov (United States)

Petrov, Irene Y.; Micci, Maria-Adelaide; Prough, Donald S.; Petrov, Yuriy; Guptarak, Jutatip; Grant, Auston C.; Parsley, Margaret A.; Bolding, Ian J.; Esenaliev, Rinat O.

2018-03-01

Optoacoustic diagnostics is based on detection and analysis of optoacoustic waves induced in tissues. It may find a number of important clinical applications in large populations of patients such as diagnostics of cerebral hypoxia, circulatory shock, etc. Recently, we proposed Nano-Pulse Laser Therapy (NPLT) which utilizes short optical pulses (typically, shorter than hundreds of nanoseconds) to generate optoacoustic waves in tissues upon stress-confined irradiation. It is well known that continuous wave low-level near-infrared light can be used for therapy/photobiomodulation to stimulate, repair, regenerate, and protect injured tissue. In the past few years, new works emerged on therapeutic effects of low-intensity ultrasound waves. The NPLT consists of irradiating tissue by both lowlevel light and optoacoustic waves/ultrasound that combines merits of low-level light and ultrasound therapies. In this work we propose optoacoustic theranostics that can be used for diagnostics, optoacoustic therapy/NPLT, and monitoring of therapeutic response during and after therapy. We developed and built pulsed, tunable, near infrared (680-1064 nm), fiber-coupled systems for optoacoustic theranostics and tested them in rats with traumatic brain injury (TBI). Low energy pulses were used for optoacoustic monitoring of cerebral blood oxygenation, while higher energy pulses were used for the NPLT. Our studies show that TBI results in cerebral hypoxia, while a 5-minute transcranial application of NPLT significantly reduces negative effects of TBI as assessed by vestibulomotor, cognitive, and immunofluorescence tests. The obtained results suggest that the optoacoustic theranostics may be used for diagnostics and management of TBI and other disorders.

Self-action of few-cycle pulses in a dispersive medium

International Nuclear Information System (INIS)

Balakin, A. A.; Litvak, A. G.; Mironov, V. A.; Skobelev, S. A.

2009-01-01

Basing on the nonlinear wave equation as the reflection-free approximation, we study the self-focusing dynamics of laser pulses under rather general assumptions about media dispersion. The methods for qualitative investigation of the self-action dynamics of ultrashort pulses are developed. It is shown that a new effect here is steepening of the longitudinal pulse profile, which is determined by the dependence of group velocity on the amplitude. Results of numerical simulation in media without dispersion and with anomalous dispersion confirm the conclusion about outrunning formation of a shock wave during pulse self-focusing. The formation of a power spectrum of the field, which is characteristic for a shock wave, is retained also when medium ionization is taken into account. In the case of a normal-dispersion medium, nonlinear dispersion leads to a violation of the symmetry in the longitudinal splitting of the pulse in the process of self-focusing. The possibility of tuning of the optical-pulse frequency into the short-wave area is shown for the pulse self-action near the zero-dispersion point.

The Generation Mechanism of Airy—Bessel Wave Packets in Free Space

International Nuclear Information System (INIS)

Ren Zhi-Jun; Ying Chao-Fu; Fan Chang-Jiang; Wu Qiong

2012-01-01

Localized optical Airy—Bessel configuration wave packets were first generated on the basis of a grating-telescope combination [Nat. Photon. 4(2010) 103]. By studying the spatially induced group velocity dispersion effect of ultrashort pulsed Bessel beams during propagation, we find the universal physical foundation of generating Airy—Bessel wave packets (ABWs) in free space. The research results are expected to open up more common channels for generating stable linear localized ABWs

Understanding the effect of pulsed electric fields on thermostability of connective tissue isolated from beef pectoralis muscle using a model system.

Science.gov (United States)

Alahakoon, A U; Oey, I; Silcock, P; Bremer, P

2017-10-01

Brisket is a low value/tough meat cut that contains a large amount of connective tissue. Conversion of collagen into gelatin during heating reduces the toughness of the connective tissue however this conversion is slow at low cooking temperatures (around 60°C). The objective of this project was to determine the ability of pulsed electric field (PEF) processing to reduce the thermal stability of connective tissue. To achieve this, a novel model system was designed in which connective tissue obtained from beef deep pectotalis muscle (brisket) was exposed to PEF at combinations of electric field strength (1.0 and 1.5kV/cm) and specific energy (50 and 100kJ/kg) within an agar matrix at electrical conductivities representing the electrical conductivity found in brisket. Differential scanning calorimetry showed that PEF treatment significantly (pconnective tissue compared to untreated samples. Increasing electric field strength and the specific energy increased the Ringer soluble collagen fraction. PEF treated samples showed higher solubilization compared to the untreated samples at both 60°C and 70°C in heat solubility test. SEM examination of PEF treated (at 1.5kV/cm and 100kJ/kg) and untreated samples revealed that PEF appeared to increase the porosity of the connective tissue structure. These finding suggest that PEF processing is a technology that could be used to improve the tenderness and decrease the cooking time of collagen rich, meat cuts. Copyright © 2017 Elsevier Ltd. All rights reserved.

Interaction of intense femtosecond laser pulses with high-Z solids

International Nuclear Information System (INIS)

Zhidkov, A.; Sasaki, Akira; Utsumi, Takayuki; Fukumoto, Ichirou; Tajima, Toshiki; Yoshida, Masatake; Kondo, Kenichi

2000-01-01

A plasma irradiated by an intense very short pulse laser can be an ultimate high brightness source of incoherent inner-shell X-ray emission of 1-30 keV. The recently developed 100 TW, 20 fs laser facility in JAERI can make considerable enhancement here. To show this a hybrid model combining hydrodynamics and collisional particle-in-cell simulations is applied. Effect of laser prepulse on the interaction of an intense s-polarized femtosecond, ∼20/40 fs, laser pulse with high-Z solid targets is studied. A new absorption mechanism originating from the interaction of the laser pulse with plasma waves excited by the relativistic component of the Lorentz force is found to increase the absorption rate over 30% even for a very short laser pulse. The obtained hot electron temperature exceeds 0.5-1 MeV at optimal conditions for absorption. Results of the simulation for lower laser pulse intensities are in good agreement with the experimental measurements of the hot electron energy distribution. (author)

Traveling wave laser system

International Nuclear Information System (INIS)

Gregg, D.W.; Kidder, R.E.; Biehl, A.T.

1975-01-01

A method is described for generating a traveling wave laser pulse of almost unlimited energy content wherein a gain medium is pumped into a traveling wave mode, the traveling wave moving at essentially the velocity of light to generate an amplifying region or zone which moves through the medium at the velocity of light in the presence of directed stimulating radiation, thereby generating a traveling coherent, directed radiation pulse moving with the amplification zone through the gain medium. (U.S.)

Molecular isomerization induced by ultrashort infrared pulses. II. Pump-dump isomerization using pairs of time-delayed half-cycle pulses.

Science.gov (United States)

Uiberacker, Christoph; Jakubetz, Werner

2004-06-22

We investigate population transfer across the barrier in a double-well potential, induced by a pair of time-delayed single-lobe half-cycle pulses. We apply this setup both to a one-dimensional (1D) quartic model potential and to a three-dimensional potential representing HCN-->HNC isomerization. Overall the results for the two systems are similar, although in the 3D system some additional features appear not seen in the 1D case. The generic mechanism of population transfer is the preparation by the pump pulse of a wave packet involving delocalized states above the barrier, followed by the essentially 1D motion of the delocalized part of wave packet across the barrier, and the eventual de-excitation by the dump pulse to localized states in the other well. The correct timing is given by the well-to-well passage time of the wave packet and its recurrence properties, and by the signs of the field lobes which determine the direction and acceleration or deceleration of the wave packet motion. In the 3D system an additional pump-pump-dump mechanism linked to wave packet motion in the reagent well can mediate isomerization. Since the transfer time and the pulse durations are of the same order of magnitude, there is also a marked dependence of the dynamics and the transfer yield on the pulse duration. Our analysis also sheds light on the pronounced carrier envelope phase dependence previously observed for isomerization and molecular dissociation with one-cycle and sub-one-cycle pulses. (c) 2004 American Institute of Physics.

Anisotropic polyvinyl alcohol hydrogel phantom for shear wave elastography in fibrous biological soft tissue: a multimodality characterization

International Nuclear Information System (INIS)

Chatelin, Simon; Bernal, Miguel; Deffieux, Thomas; Papadacci, Clément; Nahas, Amir; Boccara, Claude; Gennisson, Jean-Luc; Tanter, Mickael; Pernot, Mathieu; Flaud, Patrice

2014-01-01

Shear wave elastography imaging techniques provide quantitative measurement of soft tissues elastic properties. Tendons, muscles and cerebral tissues are composed of fibers, which induce a strong anisotropic effect on the mechanical behavior. Currently, these tissues cannot be accurately represented by existing elastography phantoms. Recently, a novel approach for orthotropic hydrogel mimicking soft tissues has been developed (Millon et al 2006 J. Biomed. Mater. Res. B 305–11). The mechanical anisotropy is induced in a polyvinyl alcohol (PVA) cryogel by stretching the physical crosslinks of the polymeric chains while undergoing freeze/thaw cycles. In the present study we propose an original multimodality imaging characterization of this new transverse isotropic (TI) PVA hydrogel. Multiple properties were investigated using a large variety of techniques at different scales compared with an isotropic PVA hydrogel undergoing similar imaging and rheology protocols. The anisotropic mechanical (dynamic and static) properties were studied using supersonic shear wave imaging technique, full-field optical coherence tomography (FFOCT) strain imaging and classical linear rheometry using dynamic mechanical analysis. The anisotropic optical and ultrasonic spatial coherence properties were measured by FFOCT volumetric imaging and backscatter tensor imaging, respectively. Correlation of mechanical and optical properties demonstrates the complementarity of these techniques for the study of anisotropy on a multi-scale range as well as the potential of this TI phantom as fibrous tissue-mimicking phantom for shear wave elastographic applications. (paper)

Anisotropic polyvinyl alcohol hydrogel phantom for shear wave elastography in fibrous biological soft tissue: a multimodality characterization

Science.gov (United States)

Chatelin, Simon; Bernal, Miguel; Deffieux, Thomas; Papadacci, Clément; Flaud, Patrice; Nahas, Amir; Boccara, Claude; Gennisson, Jean-Luc; Tanter, Mickael; Pernot, Mathieu

2014-11-01

Shear wave elastography imaging techniques provide quantitative measurement of soft tissues elastic properties. Tendons, muscles and cerebral tissues are composed of fibers, which induce a strong anisotropic effect on the mechanical behavior. Currently, these tissues cannot be accurately represented by existing elastography phantoms. Recently, a novel approach for orthotropic hydrogel mimicking soft tissues has been developed (Millon et al 2006 J. Biomed. Mater. Res. B 305-11). The mechanical anisotropy is induced in a polyvinyl alcohol (PVA) cryogel by stretching the physical crosslinks of the polymeric chains while undergoing freeze/thaw cycles. In the present study we propose an original multimodality imaging characterization of this new transverse isotropic (TI) PVA hydrogel. Multiple properties were investigated using a large variety of techniques at different scales compared with an isotropic PVA hydrogel undergoing similar imaging and rheology protocols. The anisotropic mechanical (dynamic and static) properties were studied using supersonic shear wave imaging technique, full-field optical coherence tomography (FFOCT) strain imaging and classical linear rheometry using dynamic mechanical analysis. The anisotropic optical and ultrasonic spatial coherence properties were measured by FFOCT volumetric imaging and backscatter tensor imaging, respectively. Correlation of mechanical and optical properties demonstrates the complementarity of these techniques for the study of anisotropy on a multi-scale range as well as the potential of this TI phantom as fibrous tissue-mimicking phantom for shear wave elastographic applications.