WorldWideScience

Sample records for cloud induced instabilities

  1. A simulation study of electron-cloud instability and beam-induced multipacting in the LHC

    International Nuclear Information System (INIS)

    Zimmermann, F.

    1997-02-01

    In the LHC beam pipe, photoemission and secondary emission give rise to a quasi-stationary electron cloud, which is established after a few bunch passages. The response of this electron cloud to a transversely displaced bunch resembles a short-range wakefield and can cause a fast instability. In addition, beam-induced multipacting of the electrons may lead to an enhanced gas desorption and an associated pressure increase. In this paper the authors report preliminary simulation results of the electron-cloud build-up both in a dipole magnet and in a straight section of the LHC at top energy. The effective wakefield created by the electron cloud translates into an instability rise time of about 25 ms horizontally and 130 ms vertically. This rise time is not much larger than that of the resistive-wall instability at injection energy

  2. Electron-cloud instabilities and beam-induced multipacting in the LHC and in the VLHC

    International Nuclear Information System (INIS)

    Zimmermann, F.

    1997-10-01

    In the beam pipe of the Large Hadron Collider (LHC), photoemission and secondary emission give rise to a quasi-stationary electron cloud, which is established after a few buncn passages. The response of this electron cloud to a transversely displaced bunch resembles a short-range wakefield and can cause a fast instability. In additoin, beam-induced multipacting of the electrons may lead to an enhanced gas desorption and an associated pressure increase. In this paper the authors report preliminary simulation results of the electron-cloud build-up both in a dipole magnet and in a straight section of the LHC at top energy. The effective wakefield created by the electron cloud translates into an instability rise time of about 40 ms horizontally and 500 ms vertically. This rise time is not much larger than that of the resistive-wall instability at injection energy. Similar simulation studies show that the instability rise time for the proposed Very Large Hadron Collider (VLHC) is about 3--4 s in both trasnverse planes. The smaller growth rate in the VLHC, as compared with the LHC, is primarily due to the much lower bunch population

  3. Simulation study of electron cloud induced instabilities and emittance growth for the CERN Large Hadron Collider proton beam

    CERN Document Server

    Benedetto, Elena; Schulte, Daniel; Rumolo, Giovanni

    2005-01-01

    The electron cloud may cause transverse single-bunch instabilities of proton beams such as those in the Large Hadron Collider (LHC) and the CERN Super Proton Synchrotron (SPS). We simulate these instabilities and the consequent emittance growth with the code HEADTAIL, which models the turn-by-turn interaction between the cloud and the beam. Recently some new features were added to the code, in particular, electric conducting boundary conditions at the chamber wall, transverse feedback, and variable beta functions. The sensitivity to several numerical parameters has been studied by varying the number of interaction points between the bunch and the cloud, the phase advance between them, and the number of macroparticles used to represent the protons and the electrons. We present simulation results for both LHC at injection and SPS with LHC-type beam, for different electron-cloud density levels, chromaticities, and bunch intensities. Two regimes with qualitatively different emittance growth are observed: above th...

  4. Model of E-Cloud Instability in the Fermilab Recycler

    Energy Technology Data Exchange (ETDEWEB)

    Balbekov, V. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

    2015-06-24

    Simple model of electron cloud is developed in the paper to explain e-cloud instability of bunched proton beam in the Fermilab Recycler. The cloud is presented as an immobile snake in strong vertical magnetic field. The instability is treated as an amplification of the bunch injection errors from the batch head to its tail. Nonlinearity of the e-cloud field is taken into account. Results of calculations are compared with experimental data demonstrating good correlation.

  5. Electron Cloud induced instabilities in the Fermilab Main Injector(MI) for the High Intensity Neutrino Source (HINS) project

    International Nuclear Information System (INIS)

    Sonnad, Kiran G.; Furman, Miguel A.; Vay, Jean-Luc; Venturini, Marco; Celata, Christine; Grote, David

    2006-01-01

    The electrostatic particle-in-cell codeWARP is currently being expanded in order to study electron cloud effects on the dynamics of the beam in storage rings. Results for the Fermilab main injector (MI) show the existence of a threshold in the electron density beyond which there is rapid emittance growth. The Fermilab MI is being considered for an upgrade as part of the high intensity neutrino source (HINS) effort, which will result in a significant increasing of the bunch intensity relative to its present value, placing it in a regime where electron-cloud effects are expected to become important. Various results from the simulations using WARP are discussed here

  6. Summary: Electron-cloud effects and fast-ion instability

    International Nuclear Information System (INIS)

    Furman, Miguel A.

    2000-01-01

    This is my summary of the talks on the electron-cloud effect and the fast-ion instability that were presented at the 8th ICFA Beam Dynamics Mini-Work shop on Two-Stream Instabilities in Particle Accelerators and Storage Rings,Santa Fe, NM, February 16--18, 2000

  7. Aerosol Effects on Instability, Circulations, Clouds, and Precipitation

    Directory of Open Access Journals (Sweden)

    Seoung-Soo Lee

    2014-01-01

    Full Text Available It is well known that increasing aerosol and associated changes in aerosol-cloud interactions and precipitation since industrialization have been playing an important role in climate change, but this role has not been well understood. This prevents us from predicting future climate with a good confidence. This review paper presents recent studies on the changes in the aerosol-cloud interactions and precipitation particularly in deep convective clouds. In addition, this review paper discusses how to improve our understanding of these changes by considering feedbacks among aerosol, cloud dynamics, cloud and its embedded circulations, and microphysics. Environmental instability basically determines the dynamic intensity of clouds and thus acts as one of the most important controls on these feedbacks. As a first step to the improvement of the understanding, this paper specifically elaborates on how to link the instability to the feedbacks.

  8. Radiation-induced chromosomal instability

    International Nuclear Information System (INIS)

    Ritter, S.

    1999-01-01

    Recent studies on radiation-induced chromosomal instability in the progeny of exposed mammalian cells were briefly described as well as other related studies. For the analysis of chromosomal damage in clones, cells were seeded directly after exposure in cell well-dish to form single cell clones and post-irradiation chromosome aberrations were scored. Both exposure to isoeffective doses of X-ray or 270 MeV/u C-ions (13 keV/μm) increased the number of clones with abnormal karyotype and the increase was similar for X-ray and for C-ions. Meanwhile, in the progeny of cells for mass cultures, there was no indication of a delayed expression of chromosomal damage up to 40 population doublings after the exposure. A high number of aberrant cells were only observed directly after exposure to 10.7 MeV/u O-ions, i.e. in the first cycle cells and decreased with subsequent cell divisions. The reason for these differences in the radiation-induced chromosomal instability between clonal isolates and mass culture has not been clarified. Recent studies indicated that genomic instability occurs at a high frequency in the progeny of cells irradiated with both sparsely and densely ionizing radiation. Such genomic instability is thought likely to increase the risk of carcinogenesis, but more data are required for a well understanding of the health risks resulting from radiation-induced delayed instability. (M.N.)

  9. Nonlinear Effects at the Fermilab Recycler e-Cloud Instability

    Energy Technology Data Exchange (ETDEWEB)

    Balbekov, V. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

    2016-06-10

    Theoretical analysis of e-cloud instability in the Fermilab Recycler is represented in the paper. The e-cloud in strong magnetic field is treated as a set of immovable snakes each being initiated by some proton bunch. It is shown that the instability arises because of injection errors of the bunches which increase in time and from bunch to bunch along the batch being amplified by the e-cloud electric field. The particular attention is given to nonlinear additions to the cloud field. It is shown that the nonlinearity is the main factor which restricts growth of the bunch amplitude. Possible role of the field free parts of the Recycler id discussed as well. Results of calculations are compared with experimental data demonstrating good correlation.

  10. Dynamical instabilities in magnetohydrodynamic wind-cloud interactions

    Science.gov (United States)

    Banda-Barragan, Wladimir Eduardo; Parkin, Elliot Ross; Crocker, Roland M.; Federrath, Christoph; Bicknell, Geoffrey Vincent

    2015-08-01

    We report the results from a comprehensive numerical study that investigates the role of dynamical instabilities in magnetohydrodynamic interactions between winds and spherical clouds in the interstellar medium. The growth of Kelvin-Helmholtz (KH) and Rayleigh-Taylor (RT) instabilities at interfaces between wind and cloud material is responsible for the disruption of clouds and the formation of filamentary tails. We show how different strengths and orientations of the initial magnetic field affect the development of unstable modes and the ultimate morphology of these filaments. In the weak field limit, for example, KH instabilities developing at the flanks of clouds are dominant, whilst they are suppressed when stronger fields are considered. On the other hand, perturbations that originate RT instabilities at the leading edge of clouds are enhanced when fields are locally stronger. The orientation of the field lines also plays an important role in the structure of filaments. Magnetic ropes are key features of systems in which fields are aligned with the wind velocity, whilst current sheets are favoured when the initial field is preferentially transverse to the wind velocity. We compare our findings with analytical predictions obtained from the linear theory of hydromagnetic stability and provide a classification of filamentary tails based on their morphology.

  11. Radiation induced genomic instability

    International Nuclear Information System (INIS)

    Morgan, W.

    2003-01-01

    This presentation will focus on delayed genetic effects occurring in the progeny of cells after exposure to ionizing radiation. We have developed a model system for investigating those genetic effects occurring multiple generations after radiation exposure. The presentation will describe some of the delayed effects observed after radiation exposures including delayed chromosomal rearrangements, and recombination events as determined by a plasmid based assay system. We will present new data on how changes in gene expression as measured by differential display and DNA microarray analysis provides a mechanism by which cells display a memory of irradiation, and introduce candidate genes that may play a role in initiating and perpetuation the unstable phenotype. These results will be discussed in terms of the recently described non-targeted Death Inducing Effect (DIE) where by secreted factors from clones of unstable cells can elicit effects in non irradiated cells and may serve to perpetuate the unstable phenotype in cells that themselves were not irradiated

  12. Radiation-induced instability of human genome

    International Nuclear Information System (INIS)

    Ryabchenko, N.N.; Demina, Eh.A.

    2014-01-01

    A brief review is dedicated to the phenomenon of radiation-induced genomic instability where the increased level of genomic changes in the offspring of irradiated cells is characteristic. Particular attention is paid to the problems of genomic instability induced by the low-dose radiation, role of the bystander effect in formation of radiation-induced instability, and its relationship with individual radiosensitivity. We believe that in accordance with the paradigm of modern radiobiology the increased human individual radiosensitivity can be formed due to the genome instability onset and is a significant risk factor for radiation-induced cancer

  13. Emittance growth induced by electron cloud in proton storage rings

    CERN Document Server

    Benedetto, Elena; Coppa, G

    2006-01-01

    In proton and positron storage rings with many closely spaced bunches, a large number of electrons can accumulate in the beam pipe due to various mechanisms (photoemission, residual gas ionization, beam-induced multipacting). The so-formed electron cloud interacts with the positively charged bunches, giving rise to instabilities, emittance growth and losses. This phenomenon has been observed in several existing machines such as the CERN Super Proton Synchrotron (SPS), whose operation has been constrained by the electron-cloud problem, and it is a concern for the Large Hadron Collider (LHC), under construction at CERN. The interaction between the beam and the electron cloud has features which cannot be fully taken into account by the conventional and known theories from accelerators and plasma physics. Computer simulations are indispensable for a proper prediction and understanding of the instability dynamics. The main feature which renders the beam-cloud interactions so peculiar is that the the electron cloud...

  14. Electron Cloud Build Up and Instability in the CLIC Damping Rings

    CERN Document Server

    Rumolo, G; Papaphilippou, Y

    2008-01-01

    Electron cloud can be formed in the CLIC positron damping ring and cause intolerable tune shift and beam instability. Build up simulations with the Faktor2 code, developed at CERN, have been done to predict the cloud formation in the arcs and wigglers of the damping rings. HEADTAIL simulations have been used to study the effect of this electron cloud on the beam and assess the thresholds above which the electron cloud instability would set in.

  15. Electron cloud buildup driving spontaneous vertical instabilities of stored beams in the Large Hadron Collider

    Directory of Open Access Journals (Sweden)

    Annalisa Romano

    2018-06-01

    Full Text Available At the beginning of the 2016 run, an anomalous beam instability was systematically observed at the CERN Large Hadron Collider (LHC. Its main characteristic was that it spontaneously appeared after beams had been stored for several hours in collision at 6.5 TeV to provide data for the experiments, despite large chromaticity values and high strength of the Landau-damping octupole magnet. The instability exhibited several features characteristic of those induced by the electron cloud (EC. Indeed, when LHC operates with 25 ns bunch spacing, an EC builds up in a large fraction of the beam chambers, as revealed by several independent indicators. Numerical simulations have been carried out in order to investigate the role of the EC in the observed instabilities. It has been found that the beam intensity decay is unfavorable for the beam stability when LHC operates in a strong EC regime.

  16. Radiation-induced transgenerational instability.

    Science.gov (United States)

    Dubrova, Yuri E

    2003-10-13

    To date, the analysis of mutation induction has provided an irrefutable evidence for an elevated germline mutation rate in the parents directly exposed to ionizing radiation and a number of chemical mutagens. However, the results of numerous publications suggest that radiation may also have an indirect effect on genome stability, which is transmitted through the germ line of irradiated parents to their offspring. This review describes the phenomenon of transgenerational instability and focuses on the data showing increased cancer incidence and elevated mutation rates in the germ line and somatic tissues of the offspring of irradiated parents. The possible mechanisms of transgenerational instability are also discussed.

  17. Benchmarking headtail with electron cloud instabilities observed in the LHC

    CERN Document Server

    Bartosik, H.; Iadarola, G.; Papaphilippou, Y.; Rumolo, G.

    2013-01-01

    After a successful scrubbing run in the beginning of 2011, the LHC can be presently operated with high intensity proton beams with 50 ns bunch spacing. However, strong electron cloud effects were observed during machine studies with the nominal beam with 25 ns bunch spacing. In particular, fast transverse instabilities were observed when attempting to inject trains of 48 bunches into the LHC for the first time. An analysis of the turn-by-turn bunch-bybunch data from the transverse damper pick-ups during these injection studies is presented, showing a clear signature of the electron cloud effect. These experimental observations are reproduced using numerical simulations: the electron distribution before each bunch passage is generated with PyECLOUD and used as input for a set of HEADTAIL simulations. This paper describes the simulation method as well as the sensitivity of the results to the initial conditions for the electron build-up. The potential of this type of simulations and their clear limitations on th...

  18. Damage-induced tensile instability

    International Nuclear Information System (INIS)

    Hult, J.

    1975-01-01

    The paper presents a unified description of ductile and brittle rupture phenomena in structural components under tensile loading with particular emphasis on creep rupture. Two structural elements are analyzed in detail: 1) the uniform tensile bar subject to a Heaviside history of tensile force and superimposed such loadings, i.e. staircase histories, and 2) the thinwalled spherical pressure vessel subject to a Heaviside history of internal pressure. For both these structures the conditions for instantaneous as well as delayed rupture are analysed. It is shown that a state of mechanical instability will be reached at a certain load or after a certain time. The cases of purely ductile rupture and purely brittle fracture are identified as two limiting cases of this general instability phenomenon. The Kachanov-Rabotnov damage law implies that a structural component will fail in tension only when it has reached a state of complete damage, i.e. zero load carrying capacity. The extended law predicts failure at an earlier stage of the deterioration process and is therefore more compatible with experimental observation. Further experimental support is offered by predictions for staircase loading histories, both step-up and step-down type. The presented damage theory here predicts strain histories which are in closer agreement with test data than predictions based on other phenomenological theories

  19. Mechanisms of cadmium induced genomic instability

    Energy Technology Data Exchange (ETDEWEB)

    Filipic, Metka, E-mail: metka.filipic@nib.si [National Institute of Biology, Department for Genetic Toxicology and Cancer Biology, Ljubljana (Slovenia)

    2012-05-01

    Cadmium is an ubiquitous environmental contaminant that represents hazard to humans and wildlife. It is found in the air, soil and water and, due to its extremely long half-life, accumulates in plants and animals. The main source of cadmium exposure for non-smoking human population is food. Cadmium is primarily toxic to the kidney, but has been also classified as carcinogenic to humans by several regulatory agencies. Current evidence suggests that exposure to cadmium induces genomic instability through complex and multifactorial mechanisms. Cadmium dose not induce direct DNA damage, however it induces increase in reactive oxygen species (ROS) formation, which in turn induce DNA damage and can also interfere with cell signalling. More important seems to be cadmium interaction with DNA repair mechanisms, cell cycle checkpoints and apoptosis as well as with epigenetic mechanisms of gene expression control. Cadmium mediated inhibition of DNA repair mechanisms and apoptosis leads to accumulation of cells with unrepaired DNA damage, which in turn increases the mutation rate and thus genomic instability. This increases the probability of developing not only cancer but also other diseases associated with genomic instability. In the in vitro experiments cadmium induced effects leading to genomic instability have been observed at low concentrations that were comparable to those observed in target organs and tissues of humans that were non-occupationally exposed to cadmium. Therefore, further studies aiming to clarify the relevance of these observations for human health risks due to cadmium exposure are needed.

  20. Mechanisms of cadmium induced genomic instability

    International Nuclear Information System (INIS)

    Filipič, Metka

    2012-01-01

    Cadmium is an ubiquitous environmental contaminant that represents hazard to humans and wildlife. It is found in the air, soil and water and, due to its extremely long half-life, accumulates in plants and animals. The main source of cadmium exposure for non-smoking human population is food. Cadmium is primarily toxic to the kidney, but has been also classified as carcinogenic to humans by several regulatory agencies. Current evidence suggests that exposure to cadmium induces genomic instability through complex and multifactorial mechanisms. Cadmium dose not induce direct DNA damage, however it induces increase in reactive oxygen species (ROS) formation, which in turn induce DNA damage and can also interfere with cell signalling. More important seems to be cadmium interaction with DNA repair mechanisms, cell cycle checkpoints and apoptosis as well as with epigenetic mechanisms of gene expression control. Cadmium mediated inhibition of DNA repair mechanisms and apoptosis leads to accumulation of cells with unrepaired DNA damage, which in turn increases the mutation rate and thus genomic instability. This increases the probability of developing not only cancer but also other diseases associated with genomic instability. In the in vitro experiments cadmium induced effects leading to genomic instability have been observed at low concentrations that were comparable to those observed in target organs and tissues of humans that were non-occupationally exposed to cadmium. Therefore, further studies aiming to clarify the relevance of these observations for human health risks due to cadmium exposure are needed.

  1. Electron cloud instabilities in the Proton Storage Ring and Spallation Neutron Source

    Directory of Open Access Journals (Sweden)

    M. Blaskiewicz

    2003-01-01

    Full Text Available Electron cloud instabilities in the Los Alamos Proton Storage Ring and those foreseen for the Oak Ridge Spallation Neutron Source are examined theoretically, numerically, and experimentally.

  2. Curvature-Induced Instabilities of Shells

    Science.gov (United States)

    Pezzulla, Matteo; Stoop, Norbert; Steranka, Mark P.; Bade, Abdikhalaq J.; Holmes, Douglas P.

    2018-01-01

    Induced by proteins within the cell membrane or by differential growth, heating, or swelling, spontaneous curvatures can drastically affect the morphology of thin bodies and induce mechanical instabilities. Yet, the interaction of spontaneous curvature and geometric frustration in curved shells remains poorly understood. Via a combination of precision experiments on elastomeric spherical shells, simulations, and theory, we show how a spontaneous curvature induces a rotational symmetry-breaking buckling as well as a snapping instability reminiscent of the Venus fly trap closure mechanism. The instabilities, and their dependence on geometry, are rationalized by reducing the spontaneous curvature to an effective mechanical load. This formulation reveals a combined pressurelike term in the bulk and a torquelike term in the boundary, allowing scaling predictions for the instabilities that are in excellent agreement with experiments and simulations. Moreover, the effective pressure analogy suggests a curvature-induced subcritical buckling in closed shells. We determine the critical buckling curvature via a linear stability analysis that accounts for the combination of residual membrane and bending stresses. The prominent role of geometry in our findings suggests the applicability of the results over a wide range of scales.

  3. Molecular cloud formation by gravitational instabilities in a clumpy interstellar medium

    International Nuclear Information System (INIS)

    Elmegreen, B.G.

    1989-01-01

    A dispersion relation is derived for gravitational instabilities in a medium with cloud collisional cooling, using a time-dependent energy equation instead of the adiabatic equation of state. The instability extends to much smaller length scales than in the conventional Jeans analysis, and, in regions temporarily without cloud stirring, it has a large growth rate down to the cloud collision mean free path. These results suggests that gravitational instabilities in a variety of environments, such as galactic density wave shocks, swept-up shells, and extended, quiescent regions of the interstellar medium, can form molecular clouds with masses much less than the conventional Jeans mass, e.g., from 100 to 10 million solar masses for the ambient medium, and they can do this even when the unperturbed velocity dispersion remains high. Similar processes operating inside existing clouds might promote gravitationally driven fragmentation. 29 refs

  4. Self-Induced Faraday Instability Laser

    Science.gov (United States)

    Perego, A. M.; Smirnov, S. V.; Staliunas, K.; Churkin, D. V.; Wabnitz, S.

    2018-05-01

    We predict the onset of self-induced parametric or Faraday instabilities in a laser, spontaneously caused by the presence of pump depletion, which leads to a periodic gain landscape for light propagating in the cavity. As a result of the instability, continuous wave oscillation becomes unstable even in the normal dispersion regime of the cavity, and a periodic train of pulses with ultrahigh repetition rate is generated. Application to the case of Raman fiber lasers is described, in good quantitative agreement between our conceptual analysis and numerical modeling.

  5. Fast Transverse Beam Instability Caused by Electron Cloud Trapped in Combined Function Magnets

    Energy Technology Data Exchange (ETDEWEB)

    Antipov, Sergey [Univ. of Chicago, IL (United States)

    2017-03-01

    Electron cloud instabilities affect the performance of many circular high-intensity particle accelerators. They usually have a fast growth rate and might lead to an increase of the transverse emittance and beam loss. A peculiar example of such an instability is observed in the Fermilab Recycler proton storage ring. Although this instability might pose a challenge for future intensity upgrades, its nature had not been completely understood. The phenomena has been studied experimentally by comparing the dynamics of stable and unstable beam, numerically by simulating the build-up of the electron cloud and its interaction with the beam, and analytically by constructing a model of an electron cloud driven instability with the electrons trapped in combined function dipoles. Stabilization of the beam by a clearing bunch reveals that the instability is caused by the electron cloud, trapped in beam optics magnets. Measurements of microwave propagation confirm the presence of the cloud in the combined function dipoles. Numerical simulations show that up to 10$^{-2}$ of the particles can be trapped by their magnetic field. Since the process of electron cloud build-up is exponential, once trapped this amount of electrons significantly increases the density of the cloud on the next revolution. In a combined function dipole this multi-turn accumulation allows the electron cloud reaching final intensities orders of magnitude greater than in a pure dipole. The estimated fast instability growth rate of about 30 revolutions and low mode frequency of 0.4 MHz are consistent with experimental observations and agree with the simulations. The created instability model allows investigating the beam stability for the future intensity upgrades.

  6. Single-Bunch Instability Driven by the Electron Cloud Effect in the Positron Damping Ring of the International Linear Collider

    International Nuclear Information System (INIS)

    Pivi, Mauro; Raubenheimer, Tor O.; Ghalam, Ali; Harkay, Katherine; Ohmi, Kazuhito; Wanzenberg, Rainer; Wolski, Andrzej; Zimmermann, Frank

    2005-01-01

    Collective instabilities caused by the formation of an electron cloud (EC) are a potential limitation to the performances of the damping rings for a future linear collider. In this paper, we present recent simulation results for the electron cloud build-up in damping rings of different circumferences and discuss the single-bunch instabilities driven by the electron cloud

  7. Simulation of a Feedback System for the Attenuation of e-Cloud Driven Instability

    International Nuclear Information System (INIS)

    Vay, J.-L.; Furman, M.A.; Fox, J.; Rivetta, C.; de Maria, R.; Rumolo, G.

    2009-01-01

    Electron clouds impose limitations on current accelerators that may be more severe for future machines, unless adequate measures of mitigation are taken. Recently, it has been proposed to use feedback systems operating at high frequency (in the GHz range) to damp single-bunch transverse coherent oscillations that may otherwise be amplified during the interaction of the beam with ambient electron clouds. We have used the simulation package WARP-POSINST and the code Headtail to study the growth rate and frequency patterns in space-time of the electron cloud driven beam breakup instability in the CERN SPS accelerator with, or without, an idealized feedback model for damping the instability.

  8. Formation of giant cloud complexes by the Parker-Jeans instability

    International Nuclear Information System (INIS)

    Elmegreen, B.G.

    1982-01-01

    The Parker-Jeans instability is considered as a possible mechanism for forming the giant cloud complexes observed near OB associations. We use a previously derived dispersion relation to evaluate the masses and growth times of the dominant modes in this instability. The results show that massive clouds (Mroughly-equal10 6 M/sub sun/) can form quickly (roughly-equal12 million yr) in the high density environments (5 cm -3 ) associated with spiral density wave shocks. For densities larger than about 3 cm -3 , these clouds form primarily as a result of the self-graviational forces in the interstellar medium. Lower mass clouds (Mroughly-equal10 5 M/sub sun/) can form in lower density environments as a result of the pure Parker instability. The masses of the clouds that form when the density exceeds about 3 cm -3 are insensitive to the magnetic field strength, cosmic ray pressure, and ambient density (even in compressed media.). These masses are essentially the Jeans mass in a magnetic interstellar medium. The occurrence of a characteristic mass may explain the similarity of the local OB associations. The role of the Parker-Jeans instability as part of a complete theory of cloud formation is summarized

  9. STAR FORMATION IN DISK GALAXIES. I. FORMATION AND EVOLUTION OF GIANT MOLECULAR CLOUDS VIA GRAVITATIONAL INSTABILITY AND CLOUD COLLISIONS

    International Nuclear Information System (INIS)

    Tasker, Elizabeth J.; Tan, Jonathan C.

    2009-01-01

    We investigate the formation and evolution of giant molecular clouds (GMCs) in a Milky-Way-like disk galaxy with a flat rotation curve. We perform a series of three-dimensional adaptive mesh refinement numerical simulations that follow both the global evolution on scales of ∼20 kpc and resolve down to scales ∼ H ≥ 100 cm -3 and track the evolution of individual clouds as they orbit through the galaxy from their birth to their eventual destruction via merger or via destructive collision with another cloud. After ∼140 Myr a large fraction of the gas in the disk has fragmented into clouds with masses ∼10 6 M sun and a mass spectrum similar to that of Galactic GMCs. The disk settles into a quasi-steady-state in which gravitational scattering of clouds keeps the disk near the threshold of global gravitational instability. The cloud collision time is found to be a small fraction, ∼1/5, of the orbital time, and this is an efficient mechanism to inject turbulence into the clouds. This helps to keep clouds only moderately gravitationally bound, with virial parameters of order unity. Many other observed GMC properties, such as mass surface density, angular momentum, velocity dispersion, and vertical distribution, can be accounted for in this simple model with no stellar feedback.

  10. GSK-3 inhibitors induce chromosome instability

    Directory of Open Access Journals (Sweden)

    Staples Oliver D

    2007-08-01

    Full Text Available Abstract Background Several mechanisms operate during mitosis to ensure accurate chromosome segregation. However, during tumour evolution these mechanisms go awry resulting in chromosome instability. While several lines of evidence suggest that mutations in adenomatous polyposis coli (APC may promote chromosome instability, at least in colon cancer, the underlying mechanisms remain unclear. Here, we turn our attention to GSK-3 – a protein kinase, which in concert with APC, targets β-catenin for proteolysis – and ask whether GSK-3 is required for accurate chromosome segregation. Results To probe the role of GSK-3 in mitosis, we inhibited GSK-3 kinase activity in cells using a panel of small molecule inhibitors, including SB-415286, AR-A014418, 1-Azakenpaullone and CHIR99021. Analysis of synchronised HeLa cells shows that GSK-3 inhibitors do not prevent G1/S progression or cell division. They do, however, significantly delay mitotic exit, largely because inhibitor-treated cells have difficulty aligning all their chromosomes. Although bipolar spindles form and the majority of chromosomes biorient, one or more chromosomes often remain mono-oriented near the spindle poles. Despite a prolonged mitotic delay, anaphase frequently initiates without the last chromosome aligning, resulting in chromosome non-disjunction. To rule out the possibility of "off-target" effects, we also used RNA interference to selectively repress GSK-3β. Cells deficient for GSK-3β exhibit a similar chromosome alignment defect, with chromosomes clustered near the spindle poles. GSK-3β repression also results in cells accumulating micronuclei, a hallmark of chromosome missegregation. Conclusion Thus, not only do our observations indicate a role for GSK-3 in accurate chromosome segregation, but they also raise the possibility that, if used as therapeutic agents, GSK-3 inhibitors may induce unwanted side effects by inducing chromosome instability.

  11. Simulation of wake potentials induced by relativistic proton bunches in electron clouds

    Energy Technology Data Exchange (ETDEWEB)

    Petrov, Fedor; Boine-Frankenheim, Oliver; Weiland, Thomas [Technische Universitaet Darmstadt (Germany). Institut fuer Theorie Elektromagnetischer Felder (TEMF)

    2012-07-01

    Electron clouds limit the intensity of modern high intensity hadron accelerators. Presently electron clouds are the main limiting factor for the LHC operation with 25 ns bunch trains. The bunches passing through an electron cloud induce a wake field. When the electron cloud density exceeds a certain threshold beam instabilities occur. The presence of electron clouds results in a shift of the synchronous phase, which increases if the bunch spacing is reduced. For LHC and SPS conditions we compare the longitudinal electron cloud wake potentials and stopping powers obtained using a simplified 2D electrostatic Particle-in-Cell code with fully electromagnetic simulations using VORPAL. In addition we analyze the wake fields induced by displaced or tilted bunches.

  12. Light-induced ion-acoustic instability of rarefied plasma

    International Nuclear Information System (INIS)

    Krasnov, I.V.; Sizykh, D.V.

    1987-01-01

    A new method of ion-acoustic instability excitation under the effect of coherent light, resonance to ion quantum transitions on collisionless plasma, is suggested. The light-induced ion-acoustic instability (LIIAI) considered is based on the induced progressive nonequilibrium resonance particles in the field of travelling electromagnetic wave. Principal possibility to use LIIAI in high-resolution spectroscopy and in applied problems of plasma physics, related to its instability, is pointed out

  13. Chromosomal instability induced by ionizing radiation

    International Nuclear Information System (INIS)

    Morgan, W.F.; Marder, B.A.; Day, J.P.

    1995-01-01

    There is accumulating evidence indicating genomic instability can manifest multiple generations after cellular exposure to DNA damaging agents. For instance, some cells surviving exposure to ionizing radiations show delayed reproductive cell death, delayed mutation and / or delayed chromosomal instability. Such instability, especially chromosome destabilization has been implicated in mutation, gene amplification, cellular transformation, and cell killing. To investigate chromosomal instability following DNA damage, we have used fluorescence in situ hybridization to detect chromosomal rearrangements in a human/hamster somatic hybrid cell line following exposure to ionizing radiation. Delayed chromosomal instability was detected when multiple populations of uniquely arranged metaphases were observed in clonal isolates raised from single cells. The relationship between delayed chromosomal destabilization and other endpoints of genomic instability, namely; delayed mutation and gene amplification will be discussed, as will the potential cytogenetic and molecular mechanisms contributing to delayed chromosomal instability

  14. Delayed chromosomal instability induced by DNA damage

    International Nuclear Information System (INIS)

    Morgan, W.F.; Marder, B.A.; Day, J.P.

    1994-01-01

    Cellular exposure to DNA damaging agents rapidly results in a dose dependent increase in chromosomal breakage and gross structural chromosomal rearrangements. Over recent years, evidence has been accumulating indicating genomic instability can manifest multiple generations after cellular exposure to physical and chemical DNA damaging agents. Genomic instability manifests in the progeny of surviving cells, and has been implicated in mutation, gene application, cellular transformation, and cell killing. To investigate chromosome instability following DNA damage, we have used fluorescence in situ hybridization to detect chromosomal rearrangements in a human/hamster somatic hybrid cell line following exposure to ionizing radiation. Delayed chromosomal instability was detected when multiple populations of uniquely arranged metaphases were observed in clonal isolates raised from single cells surviving X-irradiation many generations after exposure. At higher radiation doses, chromosomal instability was observed in a relatively high frequency of surviving clones and, in general, those clones showed delayed chromosome instability also showed reduced survival as measured by colony forming ability

  15. The electron-cloud instability in PEP-II: An update

    International Nuclear Information System (INIS)

    Furman, M.A.; Lambertson, G.R.

    1997-05-01

    The authors present an update on the estimate of the growth time of the multi-bunch transverse instability in the PEP-II collider arising from the interaction of the positron beam with the accumulated electron cloud. They estimate the contributions to the growth rate arising from the dipole magnets and from the pumping straight sections. They emphasize those quantities upon which the instability is most sensitive. The simulation includes measured data on the secondary emission yield for TiN-coated samples of the actual vacuum chamber. Although the analysis is still in progress, they conclude that the instability risetime is of order 1 ms, which is well within the range controllable by the feedback system

  16. SIMULATION OF E-CLOUD DRIVEN INSTABILITY AND ITS ATTENUATION USING A FEEDBACK SYSTEM IN THE CERN SPS

    International Nuclear Information System (INIS)

    Vay, J.-L.; Byrd, J.M.; Furman, M.A.; Secondo, R.; Venturini, M.; Fox, J.D.; Rivetta, C.H.; Hofle, W.

    2010-01-01

    Electron clouds have been shown to trigger fast growing instabilities on proton beams circulating in the SPS (1), and a feedback system to control the instabilities is under active development (2). We present the latest improvements to the Warp-Posinst simulation framework and feedback model, and its application to the self-consistent simulations of two consecutive bunches interacting with an electron cloud in the SPS.

  17. Simulation of E-Cloud Driven Instability And Its Attenuation Using a Feedback System in the CERN SPS

    International Nuclear Information System (INIS)

    Vay, Jean-Luc

    2012-01-01

    Electron clouds have been shown to trigger fast growing instabilities on proton beams circulating in the SPS, and a feedback system to control the instabilities is under active development. We present the latest improvements to the Warp-Posinst simulation framework and feedback model, and its application to the self-consistent simulations of two consecutive bunches interacting with an electron cloud in the SPS.

  18. Recommendation for Mitigations of the Electron Cloud Instability in the ILC

    International Nuclear Information System (INIS)

    Pivi, Mauro

    2011-01-01

    Electron cloud has been identified as one of the highest priority issues for the international Linear Collider (ILC) Damping Rings (DR). An electron cloud Working Group (WG) has evaluated the electron cloud effect and instability, and mitigation solutions for the electron cloud formation. Working group deliverables include recommendations for the baseline and alternate solutions to the electron cloud formation in various regions of the ILC Positron DR, which is presently assumed to be the 3.2 km design. Detailed studies of a range of mitigation options including coatings, clearing electrodes, grooves and novel concepts, were carried out over the previous several years by nearly 50 researchers, and the results of the studies form the basis for the recommendation. The recommendations are the result of the working group discussions held at numerous meetings and during a dedicated workshop. In addition, a number of items requiring further investigation were identified during the discussions at the Cornell meeting and studies will be carried out at CesrTA, a test accelerator dedicated to electron cloud studies, and other institutions.

  19. Anticipating Terrorist Safe Havens from Instability Induced Conflict

    Science.gov (United States)

    Shearer, Robert; Marvin, Brett

    This chapter presents recent methods developed at the Center for Army Analysis to classify patterns of nation-state instability that lead to conflict. The ungoverned areas endemic to failed nation-states provide terrorist organizations with safe havens from which to plan and execute terrorist attacks. Identification of those states at risk for instability induced conflict should help to facilitate effective counter terrorism policy planning efforts. Nation-states that experience instability induced conflict are similar in that they share common instability factors that make them susceptible to experiencing conflict. We utilize standard pattern classification algorithms to identify these patterns. First, we identify features (political, military, economic and social) that capture the instability of a nation-state. Second, we forecast the future levels of these features for each nation-state. Third, we classify each future state’s conflict potential based upon the conflict level of those states in the past most similar to the future state.

  20. Cavitation instabilities and rotordynamic effects in turbopumps and hydroturbines turbopump and inducer cavitation, experiments and design

    CERN Document Server

    Salvetti, Maria

    2017-01-01

    The book provides a detailed approach to the physics, fluid dynamics, modeling, experimentation and numerical simulation of cavitation phenomena, with special emphasis on cavitation-induced instabilities and their implications on the design and operation of high performance turbopumps and hydraulic turbines. The first part covers the fundamentals (nucleation, dynamics, thermodynamic effects, erosion) and forms of cavitation (attached cavitation, cloud cavitation, supercavitation, vortex cavitation) relevant to hydraulic turbomachinery, illustrates modern experimental techniques for the characterization, visualization and analysis of cavitating flows, and introduces the main aspects of the hydrodynamic design and performance of axial inducers, centrifugal turbopumps and hydo-turbines. The second part focuses on the theoretical modeling, experimental analysis, and practical control of cavitation-induced fluid-dynamic and rotordynamic instabilities of hydraulic turbomachinery, with special emphasis on cavitating...

  1. Substrate-induced instability in gas microstrip detectors

    International Nuclear Information System (INIS)

    Bateman, J.E.; Connolly, J.F.

    1992-12-01

    The results of a programme of research into substrate-induced gain instability in gas microstrip detectors are reported. Information has been collected on a wide range of substrates including many commonly available glasses and ceramics. A theoretical model of the gain instability is proposed. While we have not yet found an acceptable substrate for the construction of high flux detectors our experience points to electronically conductive glasses as the most promising source of a stable substrate. (Author)

  2. Simulations of the Electron Cloud Build Up and Instabilities for Various ILC Damping Ring Configurations

    International Nuclear Information System (INIS)

    Pivi, Mauro; Raubenheimer, Tor O.; Wang, Lanfa; Ohmi, Kazuhito; Wanzenberg, Rainer; Wolski, Andrzej

    2007-01-01

    In the beam pipe of the positron damping ring of the International Linear Collider (ILC), an electron cloud may be first produced by photoelectrons and ionization of residual gases and then increased by the secondary emission process. This paper reports the assessment of electron cloud effects in a number of configuration options for the ILC baseline configuration. Careful estimates were made of the secondary electron yield (sometimes in the literature also referred as secondary emission yield SEY or (delta), with a peak value (delta) max ) threshold for electron cloud build-up, and the related single- and coupled-bunch instabilities, as a function of beam current and surface properties for a variety of optics designs. When the configuration for the ILC damping rings was chosen at the end of 2005, the results from these studies were important considerations. On the basis of the joint theoretical and experimental work, the baseline configuration currently specifies a pair of 6 km damping rings for the positron beam, to mitigate the effects of the electron cloud that could present difficulties in a single 6 km ring. However, since mitigation techniques are now estimated to be sufficiently mature, a reduced single 6-km circumference is presently under consideration so as to reduce costs

  3. Out-of-phase flashing induced instabilities in CIRCUS facility

    Energy Technology Data Exchange (ETDEWEB)

    Christian Pablo Marcel; Van der Hagen, T.H.J.J. [Interfaculty Reactor Institute, Delft University of Technology, Mekelweg 15, 2629 JB Delft (Netherlands)

    2005-07-01

    Full text of publication follows: Flashing-induced instabilities are very important during the startup phase of natural-circulation boiling water reactors. To study this type of instability an axial fully scaled facility named CIRCUS was constructed. Experiments at low power and low pressure (typical startup conditions) are carried out on this steam/water natural circulation loop with two parallel risers. A detailed measurement of the void-fraction profile is possible by using needle-probes and the use of glass tubes for the riser and core sections allow to use optical techniques for velocity measurements. The flashing and the mechanism of flashing-induced instabilities are analyzed paying special attention on the strong coupling effect between the two riser channels. It is clear from the experiments that the out-of-phase instability is much more susceptible to occur than the in-phase instability in a system with two parallel risers. The instability region is found as soon as the operational boundary between single-phase and two-phase operation is crossed. The relation between the period of the oscillations and the fluid transient time is also investigated. The stability map constructed using this experimental data is also discussed. (authors)

  4. Enhanced quasi-static particle-in-cell simulation of electron cloud instabilities in circular accelerators

    Science.gov (United States)

    Feng, Bing

    Electron cloud instabilities have been observed in many circular accelerators around the world and raised concerns of future accelerators and possible upgrades. In this thesis, the electron cloud instabilities are studied with the quasi-static particle-in-cell (PIC) code QuickPIC. Modeling in three-dimensions the long timescale propagation of beam in electron clouds in circular accelerators requires faster and more efficient simulation codes. Thousands of processors are easily available for parallel computations. However, it is not straightforward to increase the effective speed of the simulation by running the same problem size on an increasingly number of processors because there is a limit to domain size in the decomposition of the two-dimensional part of the code. A pipelining algorithm applied on the fully parallelized particle-in-cell code QuickPIC is implemented to overcome this limit. The pipelining algorithm uses multiple groups of processors and optimizes the job allocation on the processors in parallel computing. With this novel algorithm, it is possible to use on the order of 102 processors, and to expand the scale and the speed of the simulation with QuickPIC by a similar factor. In addition to the efficiency improvement with the pipelining algorithm, the fidelity of QuickPIC is enhanced by adding two physics models, the beam space charge effect and the dispersion effect. Simulation of two specific circular machines is performed with the enhanced QuickPIC. First, the proposed upgrade to the Fermilab Main Injector is studied with an eye upon guiding the design of the upgrade and code validation. Moderate emittance growth is observed for the upgrade of increasing the bunch population by 5 times. But the simulation also shows that increasing the beam energy from 8GeV to 20GeV or above can effectively limit the emittance growth. Then the enhanced QuickPIC is used to simulate the electron cloud effect on electron beam in the Cornell Energy Recovery Linac

  5. CESR Conversion Damping Ring Studies of Electron Cloud Instabilities (CESR-TA)

    International Nuclear Information System (INIS)

    Rubin, David L.; Palmer, Mark A.

    2011-01-01

    In the International Linear Collider, two linear accelerators will accelerate bunches of positrons and electrons to over a hundred billion electron volts and collide them in a central detector. In order to obtain useful collision rates, the bunches, each containing twenty billion particles, must be compressed to a cross section of a few nanometers by a few hundred nanometers. In order to prepare these ultra high density bunches, damping rings (DRs) are employed before the linear accelerators. The DRs take the high emittance bunches that are provided by the electron and positron sources and, through the process of radiation damping, squeeze them into ultra low emittance beams that are ready for the main linear accelerators. In the damping rings, a number of effects can prevent the successful preparation of the beams. In the electron ring, an effect known as the fast ion instability can lead to beam growth and, in the positron ring, the build-up of an electron cloud (EC), which interacts with the circulating bunches, can produce the same effect. EC build-up and the subsequent interaction of the cloud with the positron beam in the DR have been identified as major risks for the successful construction of a linear collider. The CESRTA research program at the Cornell Electron Storage Ring (CESR) was developed in order to study the build-up of the EC, the details of its impact on ultra low emittance beams, as well as methods to mitigate the impact of the cloud. In the DR, the EC forms when synchrotron photons radiated from the circulating beam strike the walls of the vacuum chamber, resulting in the emission of photoelectrons. These low energy electrons can be accelerated across the vacuum chamber by the electric field of the beam, and strike the walls, causing the emission of secondary electrons. The secondary electrons are subsequently accelerated into the walls yet again via the same mechanism. The result is that the EC can rapidly begin to fill the vacuum chamber. In

  6. CESR Conversion Damping Ring Studies of Electron Cloud Instabilities (CESR-TA)

    Energy Technology Data Exchange (ETDEWEB)

    Rubin, David L.; Palmer, Mark A.

    2011-08-02

    In the International Linear Collider, two linear accelerators will accelerate bunches of positrons and electrons to over a hundred billion electron volts and collide them in a central detector. In order to obtain useful collision rates, the bunches, each containing twenty billion particles, must be compressed to a cross section of a few nanometers by a few hundred nanometers. In order to prepare these ultra high density bunches, damping rings (DRs) are employed before the linear accelerators. The DRs take the high emittance bunches that are provided by the electron and positron sources and, through the process of radiation damping, squeeze them into ultra low emittance beams that are ready for the main linear accelerators. In the damping rings, a number of effects can prevent the successful preparation of the beams. In the electron ring, an effect known as the fast ion instability can lead to beam growth and, in the positron ring, the build-up of an electron cloud (EC), which interacts with the circulating bunches, can produce the same effect. EC build-up and the subsequent interaction of the cloud with the positron beam in the DR have been identified as major risks for the successful construction of a linear collider. The CESRTA research program at the Cornell Electron Storage Ring (CESR) was developed in order to study the build-up of the EC, the details of its impact on ultra low emittance beams, as well as methods to mitigate the impact of the cloud. In the DR, the EC forms when synchrotron photons radiated from the circulating beam strike the walls of the vacuum chamber, resulting in the emission of photoelectrons. These low energy electrons can be accelerated across the vacuum chamber by the electric field of the beam, and strike the walls, causing the emission of secondary electrons. The secondary electrons are subsequently accelerated into the walls yet again via the same mechanism. The result is that the EC can rapidly begin to fill the vacuum chamber. In

  7. Settling-driven gravitational instabilities associated with volcanic clouds: new insights from experimental investigations

    Science.gov (United States)

    Scollo, Simona; Bonadonna, Costanza; Manzella, Irene

    2017-06-01

    Downward propagating instabilities are often observed at the bottom of volcanic plumes and clouds. These instabilities generate fingers that enhance the sedimentation of fine ash. Despite their potential influence on tephra dispersal and deposition, their dynamics is not entirely understood, undermining the accuracy of volcanic ash transport and dispersal models. Here, we present new laboratory experiments that investigate the effects of particle size, composition and concentration on finger generation and dynamics. The experimental set-up consists of a Plexiglas tank equipped with a removable plastic sheet that separates two different layers. The lower layer is a solution of water and sugar, initially denser than the upper layer, which consists of water and particles. Particles in the experiments include glass beads as well as andesitic, rhyolitic and basaltic volcanic ash. During the experiments, we removed the horizontal plastic sheet separating the two fluids. Particles were illuminated with a laser and filmed with a HD camera; particle image velocimetry (PIV) is used to analyse finger dynamics. Results show that both the number and the downward advance speed of fingers increase with particle concentration in the upper layer, while finger speed increases with particle size but is independent of particle composition. An increase in particle concentration and turbulence is estimated to take place inside the fingers, which could promote aggregation in subaerial fallout events. Finally, finger number, finger speed and particle concentration were observed to decrease with time after the formation of fingers. A similar pattern could occur in volcanic clouds when the mass supply from the eruptive vent is reduced. Observed evolution of the experiments through time also indicates that there must be a threshold of fine ash concentration and mass eruption rate below which fingers do not form; this is also confirmed by field observations.

  8. Simulation of e-cloud driven instability and its attenuation using a simulated feedback system in the CERN SPS

    International Nuclear Information System (INIS)

    Vay, J.-L.; Furman, M.A.

    2010-01-01

    Electron clouds have been shown to trigger fast growing instabilities on proton beams circulating in the SPS, and a feedback system to control the single-bunch instabilities is under active development. We present the latest improvements to the WARP-POSINST simulation framework and feedback model, and its application to the self-consistent simulations of two consecutive bunches interacting with an electron cloud in the SPS. Simulations using an idealized feedback system exhibit adequate mitigation of the instability providing that the cutoff of the feedback bandwidth is at or above 450 MHz. Artifacts from numerical noise of the injected distribution of electrons in the modeling of portions of bunch trains are discussed, and benchmarking of WARP against POSINST and HEADTAIL are presented.

  9. Electric field induced instabilities in free emulsion films

    Energy Technology Data Exchange (ETDEWEB)

    Tchoukov, P.; Dabros, T. [Natural Resources Canada, Devon, AB (Canada); Mostowfi, F. [Schlumberger DBR Technology Center, Edmonton, AB (Canada); Panchev, N. [Champion Technologies Inc., Houston, TX (United States); Czarnecki, J. [Alberta Univ., Edmonton, AB (Canada). Dept. of Chemical and Materials Engineering

    2009-07-01

    This presentation reported on a study that investigated the mechanism of electric field-induced breakdown of free emulsion films. Instability patterns were observed on the plane of a water-oil-water film following electric polarization. The length-scales of the instabilities were measured by analyzing images immediately after applying the electric field. Linear stability analysis was used to calculate the theoretical dominant wavelengths. The calculated values were found to be in good agreement with measured values. The films were formed in a thin film apparatus modified so that the oil film separated 2 aqueous phase compartments, each in contact with a platinum electrode. This enabled the measurement of disjoining pressure while applying the electric field to the film. It was concluded that breakdown of thin films induced by electric field has many applications, including electrostatic de-emulsification/desalination of crude oil and emulsion stability measurements. It was concluded that electroporation and dielectric breakdown may be responsible for electric field-induced breakdown. This study also presented evidence of an increase in electric field-induced instabilities in emulsion films resulting in rupture. tabs., figs.

  10. Self-Consistant Numerical Modeling of E-Cloud Driven Instability of a Bunch Train in the CERN SPS

    International Nuclear Information System (INIS)

    Vay, J.-L.; Furman, M.A.; Secondo, R.; Venturini, M.; Fox, J.D.; Rivetta, C.H.

    2010-01-01

    The simulation package WARP-POSINST was recently upgraded for handling multiple bunches and modeling concurrently the electron cloud buildup and its effect on the beam, allowing for direct self-consistent simulation of bunch trains generating, and interacting with, electron clouds. We have used the WARP-POSINST package on massively parallel supercomputers to study the growth rate and frequency patterns in space-time of the electron cloud driven transverse instability for a proton bunch train in the CERN SPS accelerator. Results suggest that a positive feedback mechanism exists between the electron buildup and the e-cloud driven transverse instability, leading to a net increase in predicted electron density. Comparisons to selected experimental data are also given. Electron clouds have been shown to trigger fast growing instabilities on proton beams circulating in the SPS and other accelerators. So far, simulations of electron cloud buildup and their effects on beam dynamics have been performed separately. This is a consequence of the large computational cost of the combined calculation due to large space and time scale disparities between the two processes. We have presented the latest improvements of the simulation package WARP-POSINST for the simulation of self-consistent ecloud effects, including mesh refinement, and generation of electrons from gas ionization and impact at the pipe walls. We also presented simulations of two consecutive bunches interacting with electrons clouds in the SPS, which included generation of secondary electrons. The distribution of electrons in front of the first beam was initialized from a dump taken from a preceding buildup calculation using the POSINST code. In this paper, we present an extension of this work where one full batch of 72 bunches is simulated in the SPS, including the entire buildup calculation and the self-consistent interaction between the bunches and the electrons. Comparisons to experimental data are also given.

  11. Observation of Electron Cloud Instabilities and Emittance Dilution at the Cornell Electron-Positron Storage Ring Test Accelerator

    International Nuclear Information System (INIS)

    Holtzapple, R.L.; Campbell, R.C.; McArdle, K.E.; Miller, M.I.; Totten, M.M.; Tucker, S.L.; Billing, M.G.; Dugan, G.F.; Ramirez, G.A.; Sonnad, K.G.; Williams, H.A.; Flanagan, J.; Palmer, M.A.

    2016-01-01

    Electron cloud related emittance dilution and instabilities of bunch trains limit the performance of high intensity circular colliders. One of the key goals of the Cornell electron-positron storage ring Test Accelerator (CesrTA) research program is to improve our understanding of how the electron cloud alters the dynamics of bunches within the train. Single bunch beam diagnotics have been developed to measure the beam spectra, vertical beam size, two important dynamical effects of beams interacting with the electron cloud, for bunch trains on a turn-by-turn basis. Experiments have been performed at CesrTA to probe the interaction of the electron cloud with stored positron bunch trains. The purpose of these experiments was to characterize the dependence of beam-electron cloud interactions on the machine parameters such as bunch spacing, vertical chromaticity, and bunch current. The beam dynamics of the stored beam, in the presence of the electron cloud, was quantified using: 1) a gated beam position monitor (BPM) and spectrum analyzer to measure the bunch-by-bunch frequency spectrum of the bunch trains; 2) an x-ray beam size monitor to record the bunch-by-bunch, turn-by-turn vertical size of each bunch within the trains. In this paper we report on the observations from these experiments and analyze the effects of the electron cloud on the stability of bunches in a train under many different operational conditions

  12. Pressure-anisotropy-induced nonlinearities in the kinetic magnetorotational instability

    Science.gov (United States)

    Squire, J.; Quataert, E.; Kunz, M. W.

    2017-12-01

    In collisionless and weakly collisional plasmas, such as hot accretion flows onto compact objects, the magnetorotational instability (MRI) can differ significantly from the standard (collisional) MRI. In particular, pressure anisotropy with respect to the local magnetic-field direction can both change the linear MRI dispersion relation and cause nonlinear modifications to the mode structure and growth rate, even when the field and flow perturbations are very small. This work studies these pressure-anisotropy-induced nonlinearities in the weakly nonlinear, high-ion-beta regime, before the MRI saturates into strong turbulence. Our goal is to better understand how the saturation of the MRI in a low-collisionality plasma might differ from that in the collisional regime. We focus on two key effects: (i) the direct impact of self-induced pressure-anisotropy nonlinearities on the evolution of an MRI mode, and (ii) the influence of pressure anisotropy on the `parasitic instabilities' that are suspected to cause the mode to break up into turbulence. Our main conclusions are: (i) The mirror instability regulates the pressure anisotropy in such a way that the linear MRI in a collisionless plasma is an approximate nonlinear solution once the mode amplitude becomes larger than the background field (just as in magnetohyrodynamics). This implies that differences between the collisionless and collisional MRI become unimportant at large amplitudes. (ii) The break up of large-amplitude MRI modes into turbulence via parasitic instabilities is similar in collisionless and collisional plasmas. Together, these conclusions suggest that the route to magnetorotational turbulence in a collisionless plasma may well be similar to that in a collisional plasma, as suggested by recent kinetic simulations. As a supplement to these findings, we offer guidance for the design of future kinetic simulations of magnetorotational turbulence.

  13. Direct Numerical Modeling of E-Cloud Driven Instability of a Bunch Train in the CERN SPS

    International Nuclear Information System (INIS)

    Vay, J.-L.; Furman, M.A.; Venturini, M.

    2011-01-01

    The simulation package WARP-POSINST was recently upgraded for handling multiple bunches and modeling concurrently the electron cloud buildup and its effect on the beam, allowing for direct self-consistent simulation of bunch trains generating, and interacting with, electron clouds. We have used the WARP-POSINST package on massively parallel supercomputers to study the buildup and interaction of electron clouds with a proton bunch train in the CERN SPS accelerator. Results suggest that a positive feedback mechanism exists between the electron buildup and the e-cloud driven transverse instability, leading to a net increase in predicted electron density. Electron clouds have been shown to trigger fast growing instabilities on proton beams circulating in the SPS and other accelerators. So far, simulations of electron cloud buildup and their effects on beam dynamics have been performed separately. This is a consequence of the large computational cost of the combined calculation due to large space and time scale disparities between the two processes. We have presented the latest improvements of the simulation package WARP-POSINST for the simulation of self-consistent ecloud effects, including mesh refinement, and generation of electrons from gas ionization and impact at the pipe walls. We also presented simulations of two consecutive bunches interacting with electrons clouds in the SPS, which included generation of secondary electrons. The distribution of electrons in front of the first beam was initialized from a dump taken from a preceding buildup calculation using the POSINST code. In this paper, we present an extension of this work where one full batch of 72 bunches is simulated in the SPS, including the entire buildup calculation and the self-consistent interaction between the bunches and the electrons.

  14. Graphical analysis of electron inertia induced acoustic instability

    International Nuclear Information System (INIS)

    Karmakar, P.K.; Deka, U.; Dwivedi, C.B.

    2005-01-01

    Recently, the practical significance of the asymptotic limit of m e /m i →0 for electron density distribution has been judged in a two-component plasma system with drifting ions. It is reported that in the presence of drifting ions with drift speed exceeding the ion acoustic wave speed, the electron inertial delay effect facilitates the resonance coupling of the usual fluid ion acoustic mode with the ion-beam mode. In this contribution the same instability is analyzed by graphical and numerical methods. This is to note that the obtained dispersion relation differs from those of the other known normal modes of low frequency ion plasma oscillations and waves. This is due to consideration of electron inertial delay in derivation of the dispersion relation of the ion acoustic wave fluctuations. Numerical calculations of the dispersion relation and wave energy are carried out to depict the graphical appearance of poles and positive-negative energy modes. It is found that the electron inertia induced ion acoustic wave instability arises out of linear resonance coupling between the negative and positive energy modes. Characterization of the resonance nature of the instability in Mach number space for different wave numbers of the ion acoustic mode is presented

  15. Current-induced atomic dynamics, instabilities, and Raman signals

    DEFF Research Database (Denmark)

    Lu, Jing Tao; Brandbyge, Mads; Hedegard, Per

    2012-01-01

    We derive and employ a semiclassical Langevin equation obtained from path integrals to describe the ionic dynamics of a molecular junction in the presence of electrical current. The electronic environment serves as an effective nonequilibrium bath. The bath results in random forces describing Joule...... heating, current-induced forces including the nonconservative wind force, dissipative frictional forces, and an effective Lorentz-type force due to the Berry phase of the nonequilibrium electrons. Using a generic two-level molecular model, we highlight the importance of both current-induced forces...... and Joule heating for the stability of the system. We compare the impact of the different forces, and the wide-band approximation for the electronic structure on our result. We examine the current-induced instabilities (excitation of runaway "waterwheel" modes) and investigate the signature...

  16. Chaos of radiative heat-loss-induced flame front instability.

    Science.gov (United States)

    Kinugawa, Hikaru; Ueda, Kazuhiro; Gotoda, Hiroshi

    2016-03-01

    We are intensively studying the chaos via the period-doubling bifurcation cascade in radiative heat-loss-induced flame front instability by analytical methods based on dynamical systems theory and complex networks. Significant changes in flame front dynamics in the chaotic region, which cannot be seen in the bifurcation diagrams, were successfully extracted from recurrence quantification analysis and nonlinear forecasting and from the network entropy. The temporal dynamics of the fuel concentration in the well-developed chaotic region is much more complicated than that of the flame front temperature. It exhibits self-affinity as a result of the scale-free structure in the constructed visibility graph.

  17. Gravitational Instabilities associated with volcanic clouds: new insights from experimental investigations

    Science.gov (United States)

    Scollo, Simona; Bonadonna, Costanza; Manzella, Irene

    2016-04-01

    Gravitational instabilities are often observed at the bottom of volcanic plumes and clouds generating fingers that propagate downward enhancing sedimentation of fine ash. Regardless of their potential influence on tephra dispersal and deposition, their dynamics is not completely understood, undermining the accuracy of volcanic ash transport and dispersal models. Here we present new laboratory experiments that investigate the effects of particle size, composition and concentration on finger dynamics and generation. The experimental set-up consists of a Plexiglas tank of 50 x 30.3 x 7.5 cm equipped with a removable banner for the partition of two separate layers. The lower partition is a solution of water and sugar and is therefore characterized by a higher density than the upper partition which is filled with water and particles. The upper layer is quiescent (unmixed experiments), or continually mixed using a rotary stirrer (mixed experiments). After removing the horizontal barrier that separates the two fluids, particles are illuminated with a 2W Nd-YAG laser named RayPower 2000 and filmed with a HD camera (1920x1080 pixels). Images are analysed by the Dynamic Studio Software (DANTEC) that is a tool for the acquisition and analysis of velocity and related properties of particles inside the fluids. Each particle that follows the flow and scatters light captured by the camera is analysed based on velocity vectors. Experiments are carried out in order to evaluate the main features of fingers (number, width and speed) as a function of particle type, size and initial concentration. Particles include Glass Beads (GB) with diameter 180 μm. Three initial particle concentrations in the upper layer were employed: 3 g/l, 4 g/l and 5 g/l. Results show that the number and the speed of fingers increases with particle concentration and the speed increases with particles size while it is independent on particle types. Finally, experiments point out that development of instability

  18. COMET SHOWERS ARE NOT INDUCED BY INTERSTELLAR CLOUDS

    Energy Technology Data Exchange (ETDEWEB)

    Morris, D.E.

    1985-11-01

    Encounters with interstellar clouds (IC) have been proposed by Rampino and Stothers as a cause of quasi-periodic intense comet showers leading to earth impacts, in order to explain the periodicity in marine mass extinctions found by Raup and Sepkoski. The model was described further, criticized and defended. The debate has centered on the question of whether the scale height of the clouds is small enough (in comparison to the amplitude of the oscillation of the solar system about the plane of the Galaxy) to produce a modulation in the rate of encounters. We wish to point out another serious, we believe fatal, defect in this model - the tidal fields of ICs are not strong enough to produce intense comet showers leading to earth impacts by bringing comets of the postulated inner Oort cloud into earth crossing orbits, except possibly during very rare encounters with very dense clouds. We will show that encounters with abundant clouds of low density cannot produce comet showers; cloud density N > 10{sup 3} atoms cm{sup -3} is needed to produce an intense comet shower leading to earth impacts. Furthermore, the tidal field of a dense cloud during a distant encounter is too weak to produce such showers. As a consequence, comet showers induced by ICs will be far less frequent than showers caused by passing stars. This conclusion is independent of assumptions about the radial distribution of comets in the inner Oort cloud.

  19. Survivin and chromosome instability induced by X-irradiation

    International Nuclear Information System (INIS)

    Shen Bo; Ju Guizhi; Liu Yang

    2006-01-01

    Objective: To explore the biological effect of survivin on chromosome instability induced by X-ray irradiation. Methods: Immunocytochemistry was used to detect the expression of sutvivin in HeLa cells. Carrier pSUPER-SVV was transfected into HeLa cells to interfere the expression of survivin. Flow cytometry assay was applied to detect the occurrence of polyploid at 0 h, 4 h, 12 h, and 48 h after the HeLa cells transfected with pSUPER-SVV and irradiated with 4 Gy X-rays irradiation, and compared with the group irradiated with 4 Gy X-rays but no transfection. Results: The expression of survivin was down-regulated by transfecting with small hair RNA, its depression rate was estimated to be about 32.16% at 48 h after transfection. The occurrence of polyploid giant cells was higher in the 4 Gy X-ray irradiated group at 48 h after the irradiation than the control groups (P<0.001). Being expression of survivin interfered, the occurrence at 12 h or 48 h after irradiation, however, was about two times higher than that in the control group. Conclusion: X-ray irradiation can induce chromosome instability in HeLa cells and the effect could be enhanced by interfering the expression of surviving. It was suggested that survivin plays an important role in maintaining the stability of chromosome. (authors)

  20. Cloud-Induced Uncertainty for Visual Navigation

    Science.gov (United States)

    2014-12-26

    can occur due to interference, jamming, or signal blockage in urban canyons. In GPS-denied environments, a GP- S/INS navigation system is forced to rely...physics-based approaches use equations that model fluid flow, thermodynamics, water condensation , and evapora- tion to generate clouds [4]. The drawback

  1. Strain-induced shear instability in Liverpool Bay

    Science.gov (United States)

    Wihsgott, Juliane; Palmer, Matthew R.

    2013-04-01

    Liverpool Bay is a shallow subsection of the eastern Irish Sea with large tides (10 m), which drive strong tidal currents (1 ms-1). The Bay is heavily influenced by large freshwater inputs from several Welsh and English rivers that maintain a strong and persistent horizontal density gradient. This gradient interacts with the sheared tidal currents to strain freshwater over denser pelagic water on a semi-diurnal frequency. This Strain-Induced-Periodic-Stratification (SIPS) has important implications on vertical and horizontal mixing. The subtle interaction between stratification and turbulence in this complex environment is shown to be of critical importance to freshwater transport, and subsequently the fate of associated biogeochemical and pollutant pathways. Recent work identified an asymmetry of current ellipses due to SIPS that increases shear instability in the halocline with the potential to enhance diapycnal mixing. Here, we use data from a short, high intensity process study which reveals this mid-water mechanism maintains prolonged periods of sub-critical gradient Richardson number (Ri ≤ ¼) that suggests shear instability is likely. A time series of measurements from a microstructure profiler identifies the associated increase in turbulence is short lived and 'patchy' but sufficient to promote diapycnal mixing. The significance of this mixing process is further investigated by comparing our findings with long-term observations from the Liverpool Bay Coastal Observatory. We identify that the conditions for shear instability during SIPS are regularly met and suggest that this process contributes to the current underestimates of near coastal mixing observed in regional models. To assist our understanding of the observed processes and to test the current capability of turbulence 'closure schemes' we employ a one-dimensional numerical model to investigate the physical mechanisms driving diapycnal mixing in Liverpool Bay.

  2. Star formation induced by cloud-cloud collisions and galactic giant molecular cloud evolution

    Science.gov (United States)

    Kobayashi, Masato I. N.; Kobayashi, Hiroshi; Inutsuka, Shu-ichiro; Fukui, Yasuo

    2018-05-01

    Recent millimeter/submillimeter observations towards nearby galaxies have started to map the whole disk and to identify giant molecular clouds (GMCs) even in the regions between galactic spiral structures. Observed variations of GMC mass functions in different galactic environments indicates that massive GMCs preferentially reside along galactic spiral structures whereas inter-arm regions have many small GMCs. Based on the phase transition dynamics from magnetized warm neutral medium to molecular clouds, Kobayashi et al. (2017, ApJ, 836, 175) proposes a semi-analytical evolutionary description for GMC mass functions including a cloud-cloud collision (CCC) process. Their results show that CCC is less dominant in shaping the mass function of GMCs than the accretion of dense H I gas driven by the propagation of supersonic shock waves. However, their formulation does not take into account the possible enhancement of star formation by CCC. Millimeter/submillimeter observations within the Milky Way indicate the importance of CCC in the formation of star clusters and massive stars. In this article, we reformulate the time-evolution equation largely modified from Kobayashi et al. (2017, ApJ, 836, 175) so that we additionally compute star formation subsequently taking place in CCC clouds. Our results suggest that, although CCC events between smaller clouds are more frequent than the ones between massive GMCs, CCC-driven star formation is mostly driven by massive GMCs ≳ 10^{5.5} M_{⊙} (where M⊙ is the solar mass). The resultant cumulative CCC-driven star formation may amount to a few 10 percent of the total star formation in the Milky Way and nearby galaxies.

  3. Corona-induced electrohydrodynamic instabilities in low conducting liquids

    Energy Technology Data Exchange (ETDEWEB)

    Vega, F.; Perez, A.T. [Depto. Electronica y Electromagnetismo, Facultad de Fisica, Universidad de Sevilla, Avda. Reina Mercedes, s/n. 41012, Sevilla (Spain)

    2003-06-01

    The rose-window electrohydrodynamic (EHD) instability has been observed when a perpendicular field with an additional unipolar ion injection is applied onto a low conducting liquid surface. This instability has a characteristic pattern with cells five to 10 times greater than those observed in volume instabilities caused by unipolar injection. We have used corona discharge from a metallic point to perform some measurements of the rose-window instability in low conducting liquids. The results are compared to the linear theoretical criterion for an ohmic liquid. They confirmed that the minimum voltage for this instability is much lower than that for the interfacial instability in high conducting liquids. This was predicted theoretically in the dependence of the critical voltage as a function of the non-dimensional conductivity. It is shown that in a non-ohmic liquid the rose window appears as a secondary instability after the volume instability. (orig.)

  4. Hydrodynamic instability induced liquid--solid contacts in film boiling

    International Nuclear Information System (INIS)

    Yao, S.; Henry, R.E.

    1976-01-01

    The film boiling liquid-solid contacts of saturated ethanol and water to horizontal flat gold plated copper are examined by using electric conductance probe. It is observed that the liquid-solid contacts occur over a wide temperature range, and generally, induced by hydrodynamic instabilities. The area of contact decreases exponentially with interface temperature and is liquid depth dependent. The averaged duration of contacts is strongly influenced by the dominant nucleation process, and thus, depends on the interface temperature and the wettability of the solid during the contact. The frequency of major contacts is about 1.5 times the bubble detaching frequency. It is found that the liquid-solid contacts may account for a large percentage of the film boiling heat transfer near the low temperature end of film boiling and decreases as the interface temperature increases

  5. Stress-induced roughening instabilities along surfaces of piezoelectric materials

    International Nuclear Information System (INIS)

    Chien, N.Y.; Gao, H.

    1993-01-01

    The possibility of using electric field to stabilize surfaces of piezoelectric solids against stress-induced morphological roughening is explored in this paper. Two types of idealized boundary conditions are considered: (1) a traction free and electrically insulating surface and (2) a traction free and electrically conducting surface. A perturbation solution for the energy variation associated with surface roughening suggests that the electric field can be used to suppress the roughening instability to various degrees. A completely stable state is possible in the insulating case, and kinetically more stable states can be attained in the conducting case. The stabilization has importance in reducing concentration of stress and electric fields due to microscopic surface roughness which might trigger failure processes involving dislocation, cracks and dielectric breakdown

  6. Dioxin induces genomic instability in mouse embryonic fibroblasts.

    Directory of Open Access Journals (Sweden)

    Merja Korkalainen

    Full Text Available Ionizing radiation and certain other exposures have been shown to induce genomic instability (GI, i.e., delayed genetic damage observed many cell generations later in the progeny of the exposed cells. The aim of this study was to investigate induction of GI by a nongenotoxic carcinogen, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD. Mouse embryonic fibroblasts (C3H10T1/2 were exposed to 1, 10 or 100 nM TCDD for 2 days. Micronuclei (MN and expression of selected cancer-related genes were assayed both immediately and at a delayed point in time (8 days. For comparison, similar experiments were done with cadmium, a known genotoxic agent. TCDD treatment induced an elevated frequency of MN at 8 days, but not directly after the exposure. TCDD-induced alterations in gene expression were also mostly delayed, with more changes observed at 8 days than at 2 days. Exposure to cadmium produced an opposite pattern of responses, with pronounced effects immediately after exposure but no increase in MN and few gene expression changes at 8 days. Although all responses to TCDD alone were delayed, menadione-induced DNA damage (measured by the Comet assay, was found to be increased directly after a 2-day TCDD exposure, indicating that the stability of the genome was compromised already at this time point. The results suggested a flat dose-response relationship consistent with dose-response data reported for radiation-induced GI. These findings indicate that TCDD, although not directly genotoxic, induces GI, which is associated with impaired DNA damage response.

  7. Hexavalent chromium induces chromosome instability in human urothelial cells

    Energy Technology Data Exchange (ETDEWEB)

    Wise, Sandra S. [Wise Laboratory of Environmental and Genetic Toxicology, Maine Center for Toxicology and Environmental Health, Department of Applied Medical Science, University of Southern Maine, Science Building, 96 Falmouth Street, Portland, ME 04103 (United States); Holmes, Amie L. [Wise Laboratory of Environmental and Genetic Toxicology, Maine Center for Toxicology and Environmental Health, Department of Applied Medical Science, University of Southern Maine, Science Building, 96 Falmouth Street, Portland, ME 04103 (United States); Department of Radiation Oncology, Dana Farber Cancer Institute, 450 Brookline Ave., Boston, MA 02215 (United States); Liou, Louis [Department of Pathology, Boston University School of Medicine, 670 Albany St., Boston, MA 02118 (United States); Adam, Rosalyn M. [Department of Surgery, Harvard Medical School, Boston, MA 02115 (United States); Wise, John Pierce Sr., E-mail: john.wise@louisville.edu [Wise Laboratory of Environmental and Genetic Toxicology, Maine Center for Toxicology and Environmental Health, Department of Applied Medical Science, University of Southern Maine, Science Building, 96 Falmouth Street, Portland, ME 04103 (United States)

    2016-04-01

    Numerous metals are well-known human bladder carcinogens. Despite the significant occupational and public health concern of metals and bladder cancer, the carcinogenic mechanisms remain largely unknown. Chromium, in particular, is a metal of concern as incidences of bladder cancer have been found elevated in chromate workers, and there is an increasing concern for patients with metal hip implants. However, the impact of hexavalent chromium (Cr(VI)) on bladder cells has not been studied. We compared chromate toxicity in two bladder cell lines; primary human urothelial cells and hTERT-immortalized human urothelial cells. Cr(VI) induced a concentration- and time-dependent increase in chromosome damage in both cell lines, with the hTERT-immortalized cells exhibiting more chromosome damage than the primary cells. Chronic exposure to Cr(VI) also induced a concentration-dependent increase in aneuploid metaphases in both cell lines which was not observed after a 24 h exposure. Aneuploidy induction was higher in the hTERT-immortalized cells. When we correct for uptake, Cr(VI) induces a similar amount of chromosome damage and aneuploidy suggesting that the differences in Cr(VI) sensitivity between the two cells lines were due to differences in uptake. The increase in chromosome instability after chronic chromate treatment suggests this may be a mechanism for chromate-induced bladder cancer, specifically, and may be a mechanism for metal-induced bladder cancer, in general. - Highlights: • Hexavalent chromium is genotoxic to human urothelial cells. • Hexavalent chromium induces aneuploidy in human urothelial cells. • hTERT-immortalized human urothelial cells model the effects seen in primary urothelial cells. • Hexavalent chromium has a strong likelihood of being carcinogenic for bladder tissue.

  8. Corona discharge induced snow formation in a cloud chamber.

    Science.gov (United States)

    Ju, Jingjing; Wang, Tie-Jun; Li, Ruxin; Du, Shengzhe; Sun, Haiyi; Liu, Yonghong; Tian, Ye; Bai, Yafeng; Liu, Yaoxiang; Chen, Na; Wang, Jingwei; Wang, Cheng; Liu, Jiansheng; Chin, S L; Xu, Zhizhan

    2017-09-18

    Artificial rainmaking is in strong demand especially in arid regions. Traditional methods of seeding various Cloud Condensation Nuclei (CCN) into the clouds are costly and not environment friendly. Possible solutions based on ionization were proposed more than 100 years ago but there is still a lack of convincing verification or evidence. In this report, we demonstrated for the first time the condensation and precipitation (or snowfall) induced by a corona discharge inside a cloud chamber. Ionic wind was found to have played a more significant role than ions as extra CCN. In comparison with another newly emerging femtosecond laser filamentation ionization method, the snow precipitation induced by the corona discharge has about 4 orders of magnitude higher wall-plug efficiency under similar conditions.

  9. Flow-Induced Instabilities in Pump-Turbines in China

    Directory of Open Access Journals (Sweden)

    Zhigang Zuo

    2017-08-01

    Full Text Available The stability of pump-turbines is of great importance to the operation of pumped storage power (PSP stations. Both hydraulic instabilities and operational instabilities have been reported in PSP stations in China. In order to provide a reference to the engineers and scientists working on pump-turbines, this paper summarizes the hydraulic instabilities and performance characteristics that promote the operational instabilities encountered in pump-turbine operations in China. Definitions, analytical methods, numerical and experimental studies, and main results are clarified. Precautions and countermeasures are also provided based on a literature review. The gaps between present studies and the need for engineering practice are pointed out.

  10. Study of genomic instability induced by low dose ionizing radiation

    International Nuclear Information System (INIS)

    Seoane, A.; Crudeli, C.; Dulout, F.

    2006-01-01

    The crews of commercial flights and services staff of radiology and radiotherapy from hospitals are exposed to low doses of ionizing radiation. Genomic instability includes those adverse effects observed in cells, several generations after the exposure occurred. The purpose of this study was to analyze the occurrence of genomic instability by very low doses of ionizing radiation [es

  11. Fabrication of Micromixers Utilizing Shedding Effect Induced by Electrokinetic Instability

    International Nuclear Information System (INIS)

    Fu, L-M; Tai, C-H; Tsai, C-H; Lin, C-H; Lee, C-Y

    2006-01-01

    This paper proposes a T-shaped micromixer featuring 45 deg. parallelogram barriers within the mixing channel. The proposed device obtains a rapid mixing of two sample fluids by means of the electrokinetic instability induced by shedding effect which is produced as an appropriate intensity of DC electric field of is applied. The proposed device uses a single high-voltage power source to simultaneously drive and mix the sample fluids. The effectiveness of the mixer is characterized experimentally as a function of the applied electrical field intensity and the extent to which the parallelogram barriers obstruct the mixing channel. The experimental results indicate that the mixing performance reaches 91.2% at a cross-section located 2.3 mm downstream of the T-junction when the barriers obstruct four-fifths of the channel width and an electrical field of 300V/cm is applied. The micromixing method presented in this study provides a simple low-cost solution to mixing problems in lab-on-a-chip systems

  12. Chromosomal instability can be induced by the formation of breakage-prone chromosome rearrangement junctions

    International Nuclear Information System (INIS)

    Allen, R.N.; Ritter, L.; Moore, S.R.; Grosovsky, A.J.

    2003-01-01

    Full text: Studies in our lab have led to the hypothesis that chromosomal rearrangements can generate novel breakage-prone sites, resulting in chromosomal instability acting predominantly in cis. For example, specific breakage of large blocks of centromeric region heterochromatin on chromosome 16q by treatment with 2,6-diaminopurine (DAP) is associated with repeated rearrangement of chromosome 16q during outgrowth of DAP-treated clones, thereby establishing a link between the initial site of damage and the occurrence of persistent chromosomal instability. Similarly, karyotypic analysis of gamma ray induced instability demonstrated that chromosomal rearrangements in sub-clones were significantly clustered near the site of previously identified chromosomal rearrangement junctions in unstable parental clones. This study investigates the hypothesis that integration of transfected sequences into host chromosomes could create breakage-prone junction regions and persistent genomic instability without exposure to DNA-damage agents. These junctions may mimic the unstable chromosomal rearrangements induced by DAP or radiation, and thus provide a test of the broader hypothesis that instability can to some extent be attributed to the formation of novel chromosomal breakage hot spots. These experiments were performed using human-hamster hybrid AL cells containing a single human chromosome 11, which was used to monitor instability in a chromosomal painting assay. AL cells were transfected with a 2.5 Kb fragment containing multiple copies of the 180 bp human alpha heterochromatic repeat, which resulted in chromosomal instability in 41% of the transfected clones. Parallel exposure to gamma-radiation resulted in a similar level of chromosomal instability, although control transfections with plasmid alone did not lead to karyotypic instability. Chromosomal instability induced by integration of alpha heterochromatic repeats was also frequently associated with delayed reproductive

  13. Temperature-gradient instability induced by conducting end walls

    International Nuclear Information System (INIS)

    Berk, H.L.; Ryutov, D.D.; Tsidulko, Yu.A.

    1990-04-01

    A new rapidly growing electron temperature gradient instability is found for a plasma in contact with a conducting wall. The linear instability analysis is presented and speculations are given for its nonlinear consequences. This instability illustrates that conducting walls can produce effects that are detrimental to plasma confinement. This mode should be of importance in open-ended systems including astrophysical plasmas, mirror machines and at the edge of tokamaks where field lines are open and are connected to limiters or divertors. 16 refs., 2 figs

  14. Rheticus: a cloud-based Geo-Information Service for the Detection and Monitoring of Geohazards and Infrastructural Instabilities

    Science.gov (United States)

    Chiaradia, M. T.; Samarelli, S.; Massimi, V.; Nutricato, R.; Nitti, D. O.; Morea, A.; Tijani, K.

    2017-12-01

    Geospatial information is today essential for organizations and professionals working in several industries. More and more, huge information is collected from multiple data sources and is freely available to anyone as open data. Rheticus® is an innovative cloud-based data and services hub able to deliver Earth Observation added-value products through automatic complex processes and, if appropriate, a minimum interaction with human operators. This target is achieved by means of programmable components working as different software layers in a modern enterprise system which relies on SOA (Service-Oriented-Architecture) model. Due to its spread architecture, where every functionality is defined and encapsulated in a standalone component, Rheticus is potentially highly scalable and distributable allowing different configurations depending on the user needs. This approach makes the system very flexible with respect to the services implementation, ensuring the ability to rethink and redesign the whole process with little effort. In this work, we outline the overall cloud-based platform and focus on the "Rheticus Displacement" service, aimed at providing accurate information to monitor movements occurring across landslide features or structural instabilities that could affect buildings or infrastructures. Using Sentinel-1 (S1) open data images and Multi-Temporal SAR Interferometry techniques (MTInSAR), the service is complementary to traditional survey methods, providing a long-term solution to slope instability monitoring. Rheticus automatically browses and accesses (on a weekly basis) the products of the rolling archive of ESA S1 Scientific Data Hub. S1 data are then processed by SPINUA (Stable Point Interferometry even in Unurbanized Areas), a robust MTInSAR algorithm, which is responsible of producing displacement maps immediately usable to measure movements of point and distributed scatterers, with sub-centimetric precision. We outline the automatic generation

  15. Instability induced by cross-diffusion in reaction-diffusion systems

    DEFF Research Database (Denmark)

    Tian, Canrong; Lin, Zhigui; Pedersen, Michael

    2010-01-01

    In this paper the instability of the uniform equilibrium of a general strongly coupled reaction–diffusion is discussed. In unbounded domain and bounded domain the sufficient conditions for the instability are obtained respectively. The conclusion is applied to the ecosystem, it is shown that cros...... can induce the instability of an equilibrium which is stable for the kinetic system and for the self-diffusion–reaction system.......In this paper the instability of the uniform equilibrium of a general strongly coupled reaction–diffusion is discussed. In unbounded domain and bounded domain the sufficient conditions for the instability are obtained respectively. The conclusion is applied to the ecosystem, it is shown that cross-diffusion...

  16. A novel strategy to identify the critical conditions for growth-induced instabilities.

    Science.gov (United States)

    Javili, A; Steinmann, P; Kuhl, E

    2014-01-01

    Geometric instabilities in living structures can be critical for healthy biological function, and abnormal buckling, folding, or wrinkling patterns are often important indicators of disease. Mathematical models typically attribute these instabilities to differential growth, and characterize them using the concept of fictitious configurations. This kinematic approach toward growth-induced instabilities is based on the multiplicative decomposition of the total deformation gradient into a reversible elastic part and an irreversible growth part. While this generic concept is generally accepted and well established today, the critical conditions for the formation of growth-induced instabilities remain elusive and poorly understood. Here we propose a novel strategy for the stability analysis of growing structures motivated by the idea of replacing growth by prestress. Conceptually speaking, we kinematically map the stress-free grown configuration onto a prestressed initial configuration. This allows us to adopt a classical infinitesimal stability analysis to identify critical material parameter ranges beyond which growth-induced instabilities may occur. We illustrate the proposed concept by a series of numerical examples using the finite element method. Understanding the critical conditions for growth-induced instabilities may have immediate applications in plastic and reconstructive surgery, asthma, obstructive sleep apnoea, and brain development. © 2013 Elsevier Ltd. All rights reserved.

  17. The effect of spin induced magnetization on Jeans instability of viscous and resistive quantum plasma

    International Nuclear Information System (INIS)

    Sharma, Prerana; Chhajlani, R. K.

    2014-01-01

    The effect of spin induced magnetization and electrical resistivity incorporating the viscosity of the medium is examined on the Jeans instability of quantum magnetoplasma. Formulation of the system is done by using the quantum magnetohydrodynamic model. The analysis of the problem is carried out by normal mode analysis theory. The general dispersion relation is derived from set of perturbed equations to analyse the growth rate and condition of self-gravitational Jeans instability. To discuss the influence of resistivity, magnetization, and viscosity parameters on Jeans instability, the general dispersion relation is reduced for both transverse and longitudinal mode of propagations. In the case of transverse propagation, the gravitating mode is found to be affected by the viscosity, magnetization, resistivity, and magnetic field strength whereas Jeans criterion of instability is modified by the magnetization and quantum parameter. In the longitudinal mode of propagation, the gravitating mode is found to be modified due to the viscosity and quantum correction in which the Jeans condition of instability is influenced only by quantum parameter. The other non-gravitating Alfven mode in this direction is affected by finite electrical resistivity, spin induced magnetization, and viscosity. The numerical study for the growth rate of Jeans instability is carried out for both in the transverse and longitudinal direction of propagation to the magnetic field. The effect of various parameters on the growth rate of Jeans instability in quantum plasma is analysed

  18. Ionizing radiation induced genomic instability and its relation to radiation carcinogenesis

    International Nuclear Information System (INIS)

    Wang Zhongwen

    2000-01-01

    There are widespread testimonies that the genomic instability induced by ionizing irradiation exits in mammal and its vitro cells. Genomic instability can enhance the frequency of genetic changes among the progeny of the original irradiated cells. In the radiation-leukemogenesis, there is no significant difference between controls and CBA/H mouses of PPI (preconception patent irradiation), but the offsprings of the PPI recipients show a different character (shorter latent period and higher incidence) after an extra γ-radiation. The radiation-induced genomic instability may get the genome on the verge of mutation and lead to carcinogens following mutation of some critical genes. The genomic instability, as the early event of initiation of carcinomas, may be play a specific or unique role

  19. On the ghost-induced instability on de Sitter background

    Science.gov (United States)

    Peter, Patrick; Salles, Filipe de O.; Shapiro, Ilya L.

    2018-03-01

    It is known that the perturbative instability of tensor excitations in higher derivative gravity may not take place if the initial frequency of the gravitational waves is below the Planck threshold. One can assume that this is a natural requirement if the cosmological background is sufficiently mild, since in this case the situation is qualitatively close to the free gravitational wave in flat space. Here, we explore the opposite situation and consider the effect of a very far from Minkowski radiation-dominated or de Sitter cosmological background with a large Hubble rate, e.g., typical of an inflationary period. It turns out that, then, for initial Planckian or even trans-Planckian frequencies, the instability is rapidly suppressed by the very fast expansion of the Universe.

  20. Hund's Induced Fermi-Liquid Instabilities and Enhanced Quasiparticle Interactions.

    Science.gov (United States)

    De' Medici, Luca

    2017-04-21

    Hund's coupling is shown to generally favor, in a doped half-filled Mott insulator, an increase in the compressibility culminating in a Fermi-liquid instability towards phase separation. The largest effect is found near the frontier between an ordinary and an orbitally decoupled ("Hund's") metal. The increased compressibility implies an enhancement of quasiparticle scattering, thus favoring other possible symmetry breakings. This physics is shown to happen in simulations of the 122 Fe-based superconductors, possibly implying the relevance of this mechanism in the enhancement of the critical temperature for superconductivity.

  1. Alpha-induced instabilities in tandem thermal barriers

    Energy Technology Data Exchange (ETDEWEB)

    Kammash, T.; Galbraith, D.L.

    1987-01-01

    A major premise in the operation of Tandem Mirror reactors is that the fusion reactions take place in the central cell only. The alpha particles generated by the Deuterium-Tritium (DT) fusions, along with other ions, will however pass from the central cell to the thermal barriers and return to the central cell as a result of reflection by the potential hills that exist by the plugs' side of these barriers. This streaming motion gives rise to electrostatic and electomagnetic instabilities which could detract from the barrier's function as a thermal insulator. The number density and streaming velocity of these passing particles are dictated by the electrostatic potential variation and the magnetic field structure in these regions. It is shown that, in the absence of alphas, barriers with deep potential depression are less susceptible to electrostatic instabilities while particularly vulnerable to unstable electromagnetic modes. In the presence of alphas, especially the fast alphas whose mean energy is significantly larger than the barrier potentials they see, (which is twice as high as that seen by the ions) both types of modes become unstable.

  2. Turbulent mixing induced by Richtmyer-Meshkov instability

    Science.gov (United States)

    Krivets, V. V.; Ferguson, K. J.; Jacobs, J. W.

    2017-01-01

    Richtmyer-Meshkov instability is studied in shock tube experiments with an Atwood number of 0.7. The interface is formed in a vertical shock tube using opposed gas flows, and three-dimensional random initial interface perturbations are generated by the vertical oscillation of gas column producing Faraday waves. Planar Laser Mie scattering is used for flow visualization and for measurements of the mixing process. Experimental image sequences are recorded at 6 kHz frequency and processed to obtain the time dependent variation of the integral mixing layer width. Measurements of the mixing layer width are compared with Mikaelian's [1] model in order to extract the growth exponent θ where a fairly wide range of values is found varying from θ ≈ 0.2 to 0.6.

  3. Field-induced magnetic instability within a superconducting condensate

    DEFF Research Database (Denmark)

    Mazzone, Daniel Gabriel; Raymond, Stephane; Gavilano, Jorge Luis

    2017-01-01

    The application of magnetic fields, chemical substitution, or hydrostatic pressure to strongly correlated electron materials can stabilize electronic phases with different organizational principles. We present evidence for a fieldinduced quantum phase transition, in superconducting Nd0.05Ce0.95Co...... that the magnetic instability is not magnetically driven, and we propose that it is driven by a modification of superconducting condensate at H*.......In5, that separates two antiferromagnetic phases with identical magnetic symmetry. At zero field, we find a spin-density wave that is suppressed at the critical field mu H-0* = 8 T. For H > H*, a spin-density phase emerges and shares many properties with the Q phase in CeCoIn5. These results suggest...

  4. The instability of the spiral wave induced by the deformation of elastic excitable media

    International Nuclear Information System (INIS)

    Ma Jun; Jia Ya; Wang Chunni; Li Shirong

    2008-01-01

    There are some similarities between the spiral wave in excitable media and in cardiac tissue. Much evidence shows that the appearance and instability of the spiral wave in cardiac tissue can be linked to one kind of heart disease. There are many models that can be used to investigate the formation and instability of the spiral wave. Cardiac tissue is excitable and elastic, and it is interesting to simulate the transition and instability of the spiral wave induced by media deformation. For simplicity, a class of the modified Fitzhugh-Nagumo (MFHN) model, which can generate a stable rotating spiral wave, meandering spiral wave and turbulence within appropriate parameter regions, will be used to simulate the instability of the spiral wave induced by the periodical deformation of media. In the two-dimensional case, the total acreage of elastic media is supposed to be invariable in the presence of deformation, and the problem is described with L x x L y = N x ΔxN x Δy = L' x L' y = N x Δx'N x Δy'. In our studies, elastic media are decentralized into N x N sites and the space of the adjacent sites is changed to simulate the deformation of elastic media. Based on the nonlinear dynamics theory, the deformation effect on media is simplified and simulated by perturbing the diffusion coefficients D x and D y with different periodical signals, but the perturbed diffusion coefficients are compensatory. The snapshots of our numerical results find that the spiral wave can coexist with the spiral turbulence, instability of the spiral wave and weak deformation of the spiral wave in different conditions. The ratio parameter ε and the frequency of deformation forcing play a deterministic role in inducing instability of the spiral wave. Extensive studies confirm that the instability of the spiral wave can be induced and developed only if an appropriate frequency for deformation is used. We analyze the power spectrum for the time series of the mean activator of four sampled sites

  5. The instability of the spiral wave induced by the deformation of elastic excitable media

    Science.gov (United States)

    Ma, Jun; Jia, Ya; Wang, Chun-Ni; Li, Shi-Rong

    2008-09-01

    There are some similarities between the spiral wave in excitable media and in cardiac tissue. Much evidence shows that the appearance and instability of the spiral wave in cardiac tissue can be linked to one kind of heart disease. There are many models that can be used to investigate the formation and instability of the spiral wave. Cardiac tissue is excitable and elastic, and it is interesting to simulate the transition and instability of the spiral wave induced by media deformation. For simplicity, a class of the modified Fitzhugh-Nagumo (MFHN) model, which can generate a stable rotating spiral wave, meandering spiral wave and turbulence within appropriate parameter regions, will be used to simulate the instability of the spiral wave induced by the periodical deformation of media. In the two-dimensional case, the total acreage of elastic media is supposed to be invariable in the presence of deformation, and the problem is described with Lx × Ly = N × ΔxN × Δy = L'xL'y = N × Δx'N × Δy'. In our studies, elastic media are decentralized into N × N sites and the space of the adjacent sites is changed to simulate the deformation of elastic media. Based on the nonlinear dynamics theory, the deformation effect on media is simplified and simulated by perturbing the diffusion coefficients Dx and Dy with different periodical signals, but the perturbed diffusion coefficients are compensatory. The snapshots of our numerical results find that the spiral wave can coexist with the spiral turbulence, instability of the spiral wave and weak deformation of the spiral wave in different conditions. The ratio parameter ɛ and the frequency of deformation forcing play a deterministic role in inducing instability of the spiral wave. Extensive studies confirm that the instability of the spiral wave can be induced and developed only if an appropriate frequency for deformation is used. We analyze the power spectrum for the time series of the mean activator of four sampled sites

  6. Rayleigh-Taylor and Richtmyer-Meshkov instability induced flow, turbulence, and mixing. I

    Science.gov (United States)

    Zhou, Ye

    2017-12-01

    Rayleigh-Taylor (RT) and Richtmyer-Meshkov (RM) instabilities play an important role in a wide range of engineering, geophysical, and astrophysical flows. They represent a triggering event that, in many cases, leads to large-scale turbulent mixing. Much effort has been expended over the past 140 years, beginning with the seminal work of Lord Rayleigh, to predict the evolution of the instabilities and of the instability-induced mixing layers. The objective of Part I of this review is to provide the basic properties of the flow, turbulence, and mixing induced by RT, RM, and Kelvin-Helmholtz (KH) instabilities. Historical efforts to study these instabilities are briefly reviewed, and the significance of these instabilities is discussed for a variety of flows, particularly for astrophysical flows and for the case of inertial confinement fusion. Early experimental efforts are described, and analytical attempts to model the linear, and nonlinear regimes of these mixing layers are examined. These analytical efforts include models for both single-mode and multi-mode initial conditions, as well as multi-scale models to describe the evolution. Comparisons of these models and theories to experimental and simulation studies are then presented. Next, attention is paid to the issue of the influence of stabilizing mechanisms (e.g., viscosity, surface tension, and diffuse interface) on the evolution of these instabilities, as well as the limitations and successes of numerical methods. Efforts to study these instabilities and mixing layers using group-theoretic ideas, as well as more formal notions of turbulence cascade processes during the later stages of the induced mixing layers, are inspected. A key element of the review is the discussion of the late-time self-similar scaling for the RT and RM growth factors, α and θ. These parameters are influenced by the initial conditions and much of the observed variation can be explained by this. In some cases, these instabilities

  7. Snow precipitation on Mars driven by cloud-induced night-time convection

    Science.gov (United States)

    Spiga, Aymeric; Hinson, David P.; Madeleine, Jean-Baptiste; Navarro, Thomas; Millour, Ehouarn; Forget, François; Montmessin, Franck

    2017-09-01

    Although it contains less water vapour than Earth's atmosphere, the Martian atmosphere hosts clouds. These clouds, composed of water-ice particles, influence the global transport of water vapour and the seasonal variations of ice deposits. However, the influence of water-ice clouds on local weather is unclear: it is thought that Martian clouds are devoid of moist convective motions, and snow precipitation occurs only by the slow sedimentation of individual particles. Here we present numerical simulations of the meteorology in Martian cloudy regions that demonstrate that localized convective snowstorms can occur on Mars. We show that such snowstorms--or ice microbursts--can explain deep night-time mixing layers detected from orbit and precipitation signatures detected below water-ice clouds by the Phoenix lander. In our simulations, convective snowstorms occur only during the Martian night, and result from atmospheric instability due to radiative cooling of water-ice cloud particles. This triggers strong convective plumes within and below clouds, with fast snow precipitation resulting from the vigorous descending currents. Night-time convection in Martian water-ice clouds and the associated snow precipitation lead to transport of water both above and below the mixing layers, and thus would affect Mars' water cycle past and present, especially under the high-obliquity conditions associated with a more intense water cycle.

  8. Self-induced temporal instability from a neutrino antenna

    Energy Technology Data Exchange (ETDEWEB)

    Capozzi, Francesco [Dipartimento di Fisica e Astronomia “Galileo Galilei”,Via Marzolo 8, 35131 Padova (Italy); INFN - Sezione di Padova,Via Marzolo 8, 35131 Padova (Italy); Dasgupta, Basudeb [Tata Institute of Fundamental Research,Homi Bhabha Road, Mumbai, 400005 (India); Mirizzi, Alessandro [Dipartimento Interateneo di Fisica “Michelangelo Merlin”,Via Amendola 173, 70126 Bari (Italy); INFN - Sezione di Bari,Via Amendola 173, 70126 Bari (Italy)

    2016-04-21

    It has been recently shown that the flavor composition of a self-interacting neutrino gas can spontaneously acquire a time-dependent pulsating component during its flavor evolution. In this work, we perform a more detailed study of this effect in a model where neutrinos are assumed to be emitted in a two-dimensional plane from an infinite line that acts as a neutrino antenna. We consider several examples with varying matter and neutrino densities and find that temporal instabilities with various frequencies are excited in a cascade. We compare the numerical calculations of the flavor evolution with the predictions of linearized stability analysis of the equations of motion. The results obtained with these two approaches are in good agreement in the linear regime, while a dramatic speed-up of the flavor conversions occurs in the non-linear regime due to the interactions among the different pulsating modes. We show that large flavor conversions can take place if some of the temporal modes are unstable for long enough, and that this can happen even if the matter and neutrino densities are changing, as long as they vary slowly.

  9. Agent Model Development for Assessing Climate-Induced Geopolitical Instability.

    Energy Technology Data Exchange (ETDEWEB)

    Boslough, Mark B.; Backus, George A.

    2005-12-01

    We present the initial stages of development of new agent-based computational methods to generate and test hypotheses about linkages between environmental change and international instability. This report summarizes the first year's effort of an originally proposed three-year Laboratory Directed Research and Development (LDRD) project. The preliminary work focused on a set of simple agent-based models and benefited from lessons learned in previous related projects and case studies of human response to climate change and environmental scarcity. Our approach was to define a qualitative model using extremely simple cellular agent models akin to Lovelock's Daisyworld and Schelling's segregation model. Such models do not require significant computing resources, and users can modify behavior rules to gain insights. One of the difficulties in agent-based modeling is finding the right balance between model simplicity and real-world representation. Our approach was to keep agent behaviors as simple as possible during the development stage (described herein) and to ground them with a realistic geospatial Earth system model in subsequent years. This work is directed toward incorporating projected climate data--including various C02 scenarios from the Intergovernmental Panel on Climate Change (IPCC) Third Assessment Report--and ultimately toward coupling a useful agent-based model to a general circulation model.3

  10. Experimental and numerical investigations on flashing-induced instabilities in a single channel

    Energy Technology Data Exchange (ETDEWEB)

    Marcel, Christian P.; Rohde, M.; Van Der Hagen, T.H.J.J. [Department of Physics of Nuclear Reactors, Delft University of Technology (TUDelft), Delft, 2629 JB (Netherlands)

    2009-11-15

    During the start-up phase, natural circulation BWRs (NC-BWRs) need to be operated at low pressure conditions. Such conditions favor flashing-induced instabilities due to the large hydrostatic pressure drop induced by the tall chimney. Moreover, in novel NC-BWR designs the steam separation is performed in the steam separators which create large pressure drops at the chimney outlet, which effect on stability has not been investigated yet. In this work, flashing-induced oscillations occurring in a tall, bottom heated channel are numerically investigated by using a simple linear model with three regions and an accurate implementation for estimating the water properties. The model is used to investigate flashing-induced instabilities in a channel for different values of the core inlet friction value. The results are compared with experiments obtained by using the CIRCUS facility at the same conditions, showing a good agreement. In addition, the experiments on flashing-induced instabilities are presented in a novel manner allowing visualizing new details of the phenomenon numerical stability investigations on the effect of the friction distribution are also done. It is found that by increasing the total restriction in the channel the system is destabilized. In addition, the chimney outlet restriction has a stronger destabilizing effect than the core inlet restriction. A stable two-phase region is observed prior to the instabilities in the experiments and the numerical simulations which may help to pressurize the vessel of NC-BWRs and thus reducing the effects of flashing instabilities during start-up. (author)

  11. Radiation induced chromosomal instability in lymphocytes of cancer patients

    International Nuclear Information System (INIS)

    Sudo, H.; Sagara, M.; Ban, S.; Noda, S.; Iwakawa, M.; Harada, Y.; Imai, T.; Cologne, J.B.

    2003-01-01

    Full text: Cytokinesis-blocked micronucleus (CBMN) assay has been extensively used to evaluate the radiation sensitivity of human individuals. Using the CBMN assay, Scott et al (1998, 1999) demonstrated that a fraction of radiosensitive individuals in breast cancer case population was larger than in normal individual population. However, Vral et al were very skeptical about the Scott et al's findings (2002). Under the approval from the ethical committee of NIRS, peripheral blood was obtained from 46 normal healthy females, 131 breast cancer patients, 32 cervical cancer patients and 7 female head and neck cancer patients. Radiosensitivity of T-lymphocytes was assessed by using a CBMN assay. The frequencies of MN per binucleated cell in healthy donors were 0.031(±0.010) and 0.151(±0.066) for cells treated before and after X-ray-irradiation (2Gy), respectively. Spontaneous MN frequencies in cancer patients were significantly higher than healthy donors (p < 0.001). Radiation sensitivities of breast- and head and neck-cancer patients were significantly higher than normal individuals (p < 0.001). Cervical cancer patients were more resistant to irradiation than healthy donors, though the number of cases for statistical analysis was small. (p < 0.001). We are considering that the HPV infection affected the radiosensitivity of cervical cancer cases. Because it is widely believed that one key mechanism which leads to spontaneous micronucleus formation involves an imbalance of chromosomal segregation and a chromosomal instability in patients' lymphocytes might be greater than that in normal individuals' lymphocytes. Recently, Kuschel et al (2002) demonstrated that ratios in two SNPs on XRCC3 were significantly different between cancer patients and healthy females. Then, we can suppose that the radiation-related genes with low penetrance may be involved in tumorigenesis of mammary- and head and neck-cells, and also, in patients' radiation susceptibility

  12. Evidence of a genetic instability induced by the incorporation of a DNA precursor marked with tritium

    International Nuclear Information System (INIS)

    Saintigny, Y.; Laurent, D.; Lahayel, J.B.; Roche, St.; Meynard, D.; Lopez, B.S.

    2009-01-01

    The authors report a molecular geno-toxicology investigation which allowed molecular events induced par intracellular incorporation of tritium to be studied, and the genetic instability resulting from a chronic exposure even at low dose to be analysed. For this purpose, they developed cell models (hamster tumorous cells and human fibroblasts) in which they know how to incorporate given quantities of marked nucleotides in the DNA. They show that the incorporation of tritium, even with doses which are said to be non toxic, causes a prolonged exposure of the cell to a genotoxic stress, and maybe a genetic instability due to a too great number of recombination events

  13. Telomere-mediated chromosomal instability triggers TLR4 induced inflammation and death in mice.

    Directory of Open Access Journals (Sweden)

    Rabindra N Bhattacharjee

    Full Text Available BACKGROUND: Telomeres are essential to maintain chromosomal stability. Cells derived from mice lacking telomerase RNA component (mTERC-/- mice display elevated telomere-mediated chromosome instability. Age-dependent telomere shortening and associated chromosome instability reduce the capacity to respond to cellular stress occurring during inflammation and cancer. Inflammation is one of the important risk factors in cancer progression. Controlled innate immune responses mediated by Toll-like receptors (TLR are required for host defense against infection. Our aim was to understand the role of chromosome/genome instability in the initiation and maintenance of inflammation. METHODOLOGY/PRINCIPAL FINDINGS: We examined the function of TLR4 in telomerase deficient mTERC-/- mice harbouring chromosome instability which did not develop any overt immunological disorder in pathogen-free condition or any form of cancers at this stage. Chromosome instability was measured in metaphase spreads prepared from wildtype (mTERC+/+, mTERC+/- and mTERC-/- mouse splenocytes. Peritoneal and/or bone marrow-derived macrophages were used to examine the responses of TLR4 by their ability to produce inflammatory mediators TNFalpha and IL6. Our results demonstrate that TLR4 is highly up-regulated in the immune cells derived from telomerase-null (mTERC-/- mice and lipopolysaccharide, a natural ligand for TLR4 stabilises NF-kappaB binding to its promoter by down-regulating ATF-3 in mTERC-/- macrophages. CONCLUSIONS/SIGNIFICANCE: Our findings implied that background chromosome instability in the cellular level stabilises the action of TLR4-induced NF-kappaB action and sensitises cells to produce excess pro-inflammatory mediators. Chromosome/genomic instability data raises optimism for controlling inflammation by non-toxic TLR antagonists among high-risk groups.

  14. Experimental study of the Richtmyer-Meshkov instability induced by a Mach 3 shock wave

    International Nuclear Information System (INIS)

    BP Puranik; JG Oakley; MH Anderson; R Bonaazza

    2003-01-01

    OAK-B135 An experimental investigation of a shock-induced interfacial instability (Richtmyer-Meshkov instability) is undertaken in an effort to study temporal evolution of interfacial perturbations in the late stages of development. The experiments are performed in a vertical shock tube with a square cross-section. A membraneless interface is prepared by retracting a sinusoidally shaped metal plate initially separating carbon dioxide from air, with both gases initially at atmospheric pressure. With carbon dioxide above the plate, the Rayleigh-Taylor instability commences as the plate is retracted and the amplitude of the initial sinusoidal perturbation imposed on the interface begins to grow. The interface is accelerated by a strong shock wave (M=3.08) while its shape is still sinusoidal and before the Kelvin-Helmhotz instability distorts it into the well known mushroom-like structures; its initial amplitude to wavelength ratio is large enough that the interface evolution enters its nonlinear stage very shortly after shock acceleration. The pre-shock evolution of the interface due to the Rayleigh-Taylor instability and the post-shock evolution of the interface due to the Richtmyer-Meshkov instability are visualized using planar Mie scattering. The pre-shock evolution of the interface is carried out in an independent set of experiments. The initial conditions for the Richtmyer-Meshkov experiment are determined from the pre-shock Rayleigh-Taylor growth. One image of the post-shock interface is obtained per experiment and image sequences, showing the post-shock evolution of the interface, are constructed from several experiments. The growth rate of the perturbation amplitude is measured and compared with two recent analytical models of the Richtmyer-Meshkov instability

  15. Study of Electron Cloud E ects in the DAFNE PHI-Factory for the KLOE-2 Run

    CERN Document Server

    Demma, T

    2011-01-01

    A strong horizontal instability has been observed in the the DAFNE positron ring since 2003. Experimental observations suggest an electron cloud induced coupled bunbh instability as a possible explanation. Here is reported a simulation study of the electron cloud effects in the positron ring of the DAFNE PHI factory with particular reference to the machine configuration designed for the KLOE-2 experiment.

  16. Lead Exposure Induces Telomere Instability in Human Cells.

    Directory of Open Access Journals (Sweden)

    Géraldine Pottier

    Full Text Available Lead (Pb is an important environmental contaminant due to its widespread use over many centuries. While it affects primarily every organ system of the body, the most pernicious effects of Pb are on the central nervous system leading to cognitive and behavioral modification. Despite decades of research, the mechanisms responsible for Pb toxicity remain poorly understood. Recent work has suggested that Pb exposure may have consequences on chromosomal integrity as it was shown that Pb exposure leads to the generation of γH2Ax foci, a well-established biomarker for DNA double stranded break (DSB formation. As the chromosomal localization of γH2Ax foci plays an important role in determining the molecular mechanism responsible for their formation, we examined the localization of Pb-induced foci with respect to telomeres. Indeed, short or dysfunctional telomeres (uncapped or damaged telomeres may be recognized as DSB by the DNA repair machinery, leading to "telomere-Induced Foci" (TIFs. In the current study, we show that while Pb exposure did not increase intra-chromosomal foci, it significantly induced TIFs, leading in some cases, to chromosomal abnormalities including telomere loss. The evidence suggests that these chromosomal abnormalities are likely due to perturbation of telomere replication, in particular on the lagging DNA strand. We propose a mechanism by which Pb exposure leads to the loss of telomere maintenance. As numerous studies have demonstrated a role for telomere maintenance in brain development and tissue homeostasis, our results suggest a possible mechanism for lead-induced neurotoxicity.

  17. Delay-induced wave instabilities in single-species reaction-diffusion systems

    Science.gov (United States)

    Otto, Andereas; Wang, Jian; Radons, Günter

    2017-11-01

    The Turing (wave) instability is only possible in reaction-diffusion systems with more than one (two) components. Motivated by the fact that a time delay increases the dimension of a system, we investigate the presence of diffusion-driven instabilities in single-species reaction-diffusion systems with delay. The stability of arbitrary one-component systems with a single discrete delay, with distributed delay, or with a variable delay is systematically analyzed. We show that a wave instability can appear from an equilibrium of single-species reaction-diffusion systems with fluctuating or distributed delay, which is not possible in similar systems with constant discrete delay or without delay. More precisely, we show by basic analytic arguments and by numerical simulations that fast asymmetric delay fluctuations or asymmetrically distributed delays can lead to wave instabilities in these systems. Examples, for the resulting traveling waves are shown for a Fisher-KPP equation with distributed delay in the reaction term. In addition, we have studied diffusion-induced instabilities from homogeneous periodic orbits in the same systems with variable delay, where the homogeneous periodic orbits are attracting resonant periodic solutions of the system without diffusion, i.e., periodic orbits of the Hutchinson equation with time-varying delay. If diffusion is introduced, standing waves can emerge whose temporal period is equal to the period of the variable delay.

  18. Electromagnetic interference-induced instability in CPP-GMR read heads

    International Nuclear Information System (INIS)

    Khunkitti, P.; Siritaratiwat, A.; Kaewrawang, A.; Mewes, T.; Mewes, C.K.A.; Kruesubthaworn, A.

    2016-01-01

    Electromagnetic interference (EMI) has been a significant issue for the current perpendicular-to-the-plane giant magnetoresistance (CPP-GMR) read heads because it can cause magnetic failure. Furthermore, the magnetic noise induced by the spin transfer torque (STT) effect has played an important role in the CPP read heads because it can affect the stability of the heads. Accordingly, this work proposed an investigation of the magnetic instabilities induced by EMI through the STT effect in a CPP-GMR read head via micromagnetic simulations. The magnetization fluctuation caused by EMI was examined, and then, magnetic noise was evaluated by using power spectral density analysis. It was found that the magnetization orientation can be fluctuated by EMI in close proximity to the head. The results also showed a multimode spectral density. The main contributions of the spectral density were found to originate at the edges of the stripe height sides due to the characteristics of the demagnetization field inside the free layer. Hence, the magnetic instabilities produced by EMI become a significant factor that essentially impacts the reliability of the CPP-GMR read heads. - Highlights: • The instability induced by electromagnetic interference in read head is examined. • The magnetization orientation can be fluctuated by electromagnetic interference. • The electromagnetic interference can induce additional noise spectra to the system. • The noise is mainly located at stripe height of the read head. • The noise induced by electromagnetic interference is a crucial factor for the head.

  19. Pomegranate Intake Protects Against Genomic Instability Induced by Medical X-rays In Vivo in Mice.

    Science.gov (United States)

    Nallanthighal, Sameera; Shirode, Amit B; Judd, Julius A; Reliene, Ramune

    2016-01-01

    Ionizing radiation (IR) is a well-documented human carcinogen. The increased use of IR in medical procedures has doubled the annual radiation dose and may increase cancer risk. Genomic instability is an intermediate lesion in IR-induced cancer. We examined whether pomegranate extract (PE) suppresses genomic instability induced by x-rays. Mice were treated orally with PE and exposed to an x-ray dose of 2 Gy. PE intake suppressed x-ray-induced DNA double-strand breaks (DSBs) in peripheral blood and chromosomal damage in bone marrow. We hypothesized that PE-mediated protection against x-ray-induced damage may be due to the upregulation of DSB repair and antioxidant enzymes and/or increase in glutathione (GSH) levels. We found that expression of DSB repair genes was not altered (Nbs1 and Rad50) or was reduced (Mre11, DNA-PKcs, Ku80, Rad51, Rad52 and Brca2) in the liver of PE-treated mice. Likewise, mRNA levels of antioxidant enzymes were reduced (Gpx1, Cat, and Sod2) or were not altered (HO-1 and Sod1) as a function of PE treatment. In contrast, PE-treated mice with and without IR exposure displayed higher hepatic GSH concentrations than controls. Thus, ingestion of pomegranate polyphenols is associated with inhibition of x-ray-induced genomic instability and elevated GSH, which may reduce cancer risk.

  20. Electromagnetic interference-induced instability in CPP-GMR read heads

    Energy Technology Data Exchange (ETDEWEB)

    Khunkitti, P.; Siritaratiwat, A.; Kaewrawang, A. [KKU-Seagate Cooperation Research Laboratory, Department of Electrical Engineering, Faculty of Engineering, Khon Kaen University, Khon Kaen 40002 (Thailand); Mewes, T.; Mewes, C.K.A. [Department of Physics and Astronomy, MINT Center, University of Alabama, Tuscaloosa, AL 35487 (United States); Kruesubthaworn, A., E-mail: anankr@kku.ac.th [KKU-Seagate Cooperation Research Laboratory, Department of Electrical Engineering, Faculty of Engineering, Khon Kaen University, Khon Kaen 40002 (Thailand)

    2016-08-15

    Electromagnetic interference (EMI) has been a significant issue for the current perpendicular-to-the-plane giant magnetoresistance (CPP-GMR) read heads because it can cause magnetic failure. Furthermore, the magnetic noise induced by the spin transfer torque (STT) effect has played an important role in the CPP read heads because it can affect the stability of the heads. Accordingly, this work proposed an investigation of the magnetic instabilities induced by EMI through the STT effect in a CPP-GMR read head via micromagnetic simulations. The magnetization fluctuation caused by EMI was examined, and then, magnetic noise was evaluated by using power spectral density analysis. It was found that the magnetization orientation can be fluctuated by EMI in close proximity to the head. The results also showed a multimode spectral density. The main contributions of the spectral density were found to originate at the edges of the stripe height sides due to the characteristics of the demagnetization field inside the free layer. Hence, the magnetic instabilities produced by EMI become a significant factor that essentially impacts the reliability of the CPP-GMR read heads. - Highlights: • The instability induced by electromagnetic interference in read head is examined. • The magnetization orientation can be fluctuated by electromagnetic interference. • The electromagnetic interference can induce additional noise spectra to the system. • The noise is mainly located at stripe height of the read head. • The noise induced by electromagnetic interference is a crucial factor for the head.

  1. Mitigation of radiation-pressure-induced angular instability of a Fabry–Perot cavity consisting of suspended mirrors

    Energy Technology Data Exchange (ETDEWEB)

    Nagano, Koji, E-mail: knagano@icrr.u-tokyo.ac.jp [KAGRA Observatory, Institute for Cosmic Ray Research, The University of Tokyo, 5-1-5 Kashiwa-no-Ha, Kashiwa, Chiba 277-8582 (Japan); Enomoto, Yutaro; Nakano, Masayuki [KAGRA Observatory, Institute for Cosmic Ray Research, The University of Tokyo, 5-1-5 Kashiwa-no-Ha, Kashiwa, Chiba 277-8582 (Japan); Furusawa, Akira [Department of Applied Physics, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan); Kawamura, Seiji [KAGRA Observatory, Institute for Cosmic Ray Research, The University of Tokyo, 5-1-5 Kashiwa-no-Ha, Kashiwa, Chiba 277-8582 (Japan)

    2016-12-01

    To observe radiation pressure noise in optical cavities consisting of suspended mirrors, high laser power is necessary. However, because the radiation pressure on the mirrors could cause an angular anti-spring effect, the high laser power could induce angular instability to the cavity. An angular control system using radiation pressure as an actuator, which was previously invented to reduce the anti-spring effect for the low power case, was applied to the higher power case where the angular instability would occur. As a result the angular instability was mitigated. It was also demonstrated that the cavity was unstable without this control system. - Highlights: • High laser power could cause angular instability to a suspended Fabry–Perot cavity. • To mitigate the instability, the control system using radiation pressure is applied. • Mitigating the radiation-pressure-induced angular instability is demonstrated. • It is also confirmed that the cavity would be unstable without the control system.

  2. Light induced modulation instability of surfaces under intense illumination

    KAUST Repository

    Burlakov, V. M.

    2013-12-17

    We show that a flat surface of a polymer in rubber state illuminated with intense electromagnetic radiation is unstable with respect to periodic modulation. Initial periodic perturbation is amplified due to periodic thermal expansion of the material heated by radiation. Periodic heating is due to focusing-defocusing effects caused by the initial surface modulation. The surface modulation has a period longer than the excitation wavelength and does not require coherent light source. Therefore, it is not related to the well-known laser induced periodic structures on polymer surfaces but may contribute to their formation and to other phenomena of light-matter interaction.

  3. Aerosol-Induced Changes of Convective Cloud Anvils Produce Strong Climate Warming

    Science.gov (United States)

    Koren, I.; Remer, L. A.; Altaratz, O.; Martins, J. V.; Davidi, A.

    2010-01-01

    The effect of aerosol on clouds poses one of the largest uncertainties in estimating the anthropogenic contribution to climate change. Small human-induced perturbations to cloud characteristics via aerosol pathways can create a change in the top-of-atmosphere radiative forcing of hundreds of Wm(exp-2) . Here we focus on links between aerosol and deep convective clouds of the Atlantic and Pacific Intertropical Convergence Zones, noting that the aerosol environment in each region is entirely different. The tops of these vertically developed clouds consisting of mostly ice can reach high levels of the atmosphere, overshooting the lower stratosphere and reaching altitudes greater than 16 km. We show a link between aerosol, clouds and the free atmosphere wind profile that can change the magnitude and sign of the overall climate radiative forcing. We find that increased aerosol loading is associated with taller cloud towers and anvils. The taller clouds reach levels of enhanced wind speeds that act to spread and thin the anvi1 clouds, increasing areal coverage and decreasing cloud optical depth. The radiative effect of this transition is to create a positive radiative forcing (warming) at top-of-atmosphere. Furthermore we introduce the cloud optical depth (r), cloud height (Z) forcing space and show that underestimation of radiative forcing is likely to occur in cases of non homogenous clouds. Specifically, the mean radiative forcing of towers and anvils in the same scene can be several times greater than simply calculating the forcing from the mean cloud optical depth in the scene. Limitations of the method are discussed, alternative sources of aerosol loading are tested and meteorological variance is restricted, but the trend of taller clouds; increased and thinner anvils associated with increased aerosol loading remains robust through all the different tests and perturbations.

  4. Aerosol-induced changes of convective cloud anvils produce strong climate warming

    Directory of Open Access Journals (Sweden)

    I. Koren

    2010-05-01

    Full Text Available The effect of aerosol on clouds poses one of the largest uncertainties in estimating the anthropogenic contribution to climate change. Small human-induced perturbations to cloud characteristics via aerosol pathways can create a change in the top-of-atmosphere radiative forcing of hundreds of Wm−2. Here we focus on links between aerosol and deep convective clouds of the Atlantic and Pacific Intertropical Convergence Zones, noting that the aerosol environment in each region is entirely different. The tops of these vertically developed clouds consisting of mostly ice can reach high levels of the atmosphere, overshooting the lower stratosphere and reaching altitudes greater than 16 km. We show a link between aerosol, clouds and the free atmosphere wind profile that can change the magnitude and sign of the overall climate radiative forcing.

    We find that increased aerosol loading is associated with taller cloud towers and anvils. The taller clouds reach levels of enhanced wind speeds that act to spread and thin the anvil clouds, increasing areal coverage and decreasing cloud optical depth. The radiative effect of this transition is to create a positive radiative forcing (warming at top-of-atmosphere.

    Furthermore we introduce the cloud optical depth (τ, cloud height (Z forcing space and show that underestimation of radiative forcing is likely to occur in cases of non homogenous clouds. Specifically, the mean radiative forcing of towers and anvils in the same scene can be several times greater than simply calculating the forcing from the mean cloud optical depth in the scene.

    Limitations of the method are discussed, alternative sources of aerosol loading are tested and meteorological variance is restricted, but the trend of taller clouds, increased and thinner anvils associated with increased aerosol loading remains robust through all the different tests and perturbations.

  5. Radiation-induced Genomic Instability and Radiation Sensitivity

    Energy Technology Data Exchange (ETDEWEB)

    Varnum, Susan M.; Sowa, Marianne B.; Kim, Grace J.; Morgan, William F.

    2013-01-19

    The obvious relationships between reactive oxygen and nitrogen species, mitochondrial dysfunction, inflammatory type responses and reactive chemokines and cytokines suggests a general stress response induced by ionizing radiation most likely leads to the non-targeted effects described after radiation exposure. We argue that true bystander effects do not occur in the radiation therapy clinic. But there is no question that effects outside the target volume do occur. These “out of field effects” are considered very low dose effects in the context of therapy. So what are the implications of non-targeted effects on radiation sensitivity? The primary goal of therapy is to eradicate the tumor. Given the genetic diversity of the human population, lifestyle and environment factors it is likely some combination of these will influence patient outcome. Non-targeted effects may contribute to a greater or lesser extent. But consider the potential situation involving a partial body exposure due to a radiation accident or radiological terrorism. Non-targeted effects suggest that the tissue at risk for demonstrating possible detrimental effects of radiation exposure might be greater than the volume actually irradiated.

  6. Inhibiting extracellular matrix metalloproteinase inducer maybe beneficial for diminishing the atherosclerotic plaque instability

    Directory of Open Access Journals (Sweden)

    Xie S

    2009-01-01

    Full Text Available Atherosclerotic plaque rupture and local thrombosis activation in the artery cause acute serious incidents such as acute coronary syndrome and stroke. The exact mechanism of plaque rupture remains unclear but excessive degradation of the extracellular matrix scaffold by matrix-degrading metalloproteinases (MMPs has been implicated as one of the major molecular mechanisms in this process. Convincing evidence is available to prove that extracellular matrix metalloproteinase inducer (EMMPRIN induces MMP expression and is involved in the inflammatory responses in the artery wall. The inflammation and MMPs have been shown to play a critical role for atherosclerotic lesion development and progression. More recent data showed that increased EMMPRIN expression was associated with vulnerable atherosclerotic lesions. Therefore, we speculate that EMMPRIN may be pivotal for atherosclerotic plaque instability, and hence inhibition of EMMPRIN expression could be a promising approach for the prevention or treatment of atheroma instability.

  7. Epstein–Barr virus particles induce centrosome amplification and chromosomal instability

    Science.gov (United States)

    Shumilov, Anatoliy; Tsai, Ming-Han; Schlosser, Yvonne T.; Kratz, Anne-Sophie; Bernhardt, Katharina; Fink, Susanne; Mizani, Tuba; Lin, Xiaochen; Jauch, Anna; Mautner, Josef; Kopp-Schneider, Annette; Feederle, Regina; Hoffmann, Ingrid; Delecluse, Henri-Jacques

    2017-01-01

    Infections with Epstein–Barr virus (EBV) are associated with cancer development, and EBV lytic replication (the process that generates virus progeny) is a strong risk factor for some cancer types. Here we report that EBV infection of B-lymphocytes (in vitro and in a mouse model) leads to an increased rate of centrosome amplification, associated with chromosomal instability. This effect can be reproduced with virus-like particles devoid of EBV DNA, but not with defective virus-like particles that cannot infect host cells. Viral protein BNRF1 induces centrosome amplification, and BNRF1-deficient viruses largely lose this property. These findings identify a new mechanism by which EBV particles can induce chromosomal instability without establishing a chronic infection, thereby conferring a risk for development of tumours that do not necessarily carry the viral genome. PMID:28186092

  8. Fog and Cloud Induced Aerosol Modification Observed by AERONET

    Science.gov (United States)

    Eck, T. F.; Holben, B. N.; Reid, J. S.; Giles, D. M.; Rivas, M. A.; Singh, R. P.; Tripathi, S. N.; Bruegge, C. J.; Platnick, S. E.; Arnold, G. T.; hide

    2011-01-01

    Large fine mode (sub-micron radius) dominated aerosols in size distributions retrieved from AERONET have been observed after fog or low-altitude cloud dissipation events. These column-integrated size distributions have been obtained at several sites in many regions of the world, typically after evaporation of low altitude cloud such as stratocumulus or fog. Retrievals with cloud processed aerosol are sometimes bimodal in the accumulation mode with the larger size mode often approx.0.4 - 0.5 microns radius (volume distribution); the smaller mode typically approx.0.12 to aprrox.0.20 microns may be interstitial aerosol that were not modified by incorporation in droplets and/or aerosol that are less hygroscopic in nature. Bimodal accumulation mode size distributions have often been observed from in situ measurements of aerosols that have interacted with clouds, and AERONET size distribution retrievals made after dissipation of cloud or fog are in good agreement with particle sizes measured by in situ techniques for cloud-processed aerosols. Aerosols of this type and large size range (in lower concentrations) may also be formed by cloud processing in partly cloudy conditions and may contribute to the shoulder of larger size particles in the accumulation mode retrievals, especially in regions where sulfate and other soluble aerosol are a significant component of the total aerosol composition. Observed trends of increasing aerosol optical depth (AOD) as fine mode radius increased suggests higher AOD in the near cloud environment and therefore greater aerosol direct radiative forcing than typically obtained from remote sensing, due to bias towards sampling at low cloud fraction.

  9. Nonlinear instabilities induced by the F coil power amplifier at FTU: Modeling and control

    International Nuclear Information System (INIS)

    Zaccarian, L.; Boncagni, L.; Cascone, D.; Centioli, C.; Cerino, S.; Gravanti, F.; Iannone, F.; Mecocci, F.; Pangione, L.; Podda, S.; Vitale, V.; Vitelli, R.

    2009-01-01

    In this paper we focus on the instabilities caused by the nonlinear behavior of the F coil current amplifier at FTU. This behavior induces closed-loop instability of the horizontal position stabilizing loop whenever the requested current is below the circulating current level. In the paper we first illustrate a modeling phase where nonlinear dynamics are derived and identified to reproduce the open-loop responses measured by the F coil current amplifier. The derived model is shown to successfully reproduce the experimental behavior by direct comparison with experimental data. Based on this dynamic model, we then reproduce the closed-loop scenario of the experiment and show that the proposed nonlinear model successfully reproduces the nonlinear instabilities experienced in the experimental sessions. Given the simulation setup, we next propose a nonlinear control solution to this instability problem. The proposed solution is shown to recover stability in closed-loop simulations. Experimental tests are scheduled for the next experimental campaign after the FTU restart.

  10. Saturation of radiation-induced parametric instabilities by excitation of Langmuir turbulence

    Energy Technology Data Exchange (ETDEWEB)

    Dubois, D.F.; Rose, H.A. [Los Alamos National Lab., NM (United States); Russell, D. [Lodestar Research Inc., Boulder, CO (United States)

    1995-12-01

    Progress made in the last few years in the calculation of the saturation spectra of parametric instabilities which involve Langmuir daughter waves will be reviewed. These instabilities include the ion acoustic decay instability, the two plasmon decay instability (TPDI), and stimulated Raman scattering (SRS). In particular I will emphasize spectral signatures which can be directly compared with experiment. The calculations are based on reduced models of driven Laugmuir turbulence. Thomson scattering from hf-induced Langmuir turbulence in the unpreconditioned ionosphere has resulted in detailed agreement between theory and experiment at early times. Strong turbulence signatures dominate in this regime where the weak turbulence approximation fails completely. Recent experimental studies of the TPDI have measured the Fourier spectra of Langmuir waves as well as the angular and frequency, spectra of light emitted near 3/2 of the pump frequency again permitting some detailed comparisons with theory. The experiments on SRS are less detailed but by Thomson scattering the secondary decay of the daughter Langmuir wave has been observed. Scaling laws derived from a local model of SRS saturation are compared with full simulations and recent Nova experiments.

  11. Saturation of radiation-induced parametric instabilities by excitation of Langmuir turbulence

    International Nuclear Information System (INIS)

    DuBois, D.F.

    1996-01-01

    Progress made in the last few years in the calculation of the saturation spectra of parametric instabilities which involve Langmuir daughter waves will be reviewed. These instabilities include the ion acoustic decay instability, the two plasmon decay instability (TPDI), and stimulated Raman scattering (SRS). In particular we will emphasize spectral signatures which can be directly compared with experiment. The calculations are based on reduced models of driven Langmuir turbulence. Thomson scattering from hf-induced Langmuir turbulence in the unpreconditioned ionosphere has resulted in detailed agreement between theory and experiment at early times. Strong turbulence signatures dominate in this regime where the weak turbulence approximation fails completely. Recent experimental studies of the TPDI have measured the Fourier spectra of Langmuir waves as well as the angular and frequency spectra of light emitted near 3/2 of the pump frequency again permitting some detailed comparisons with theory. Thomson scattering measurements of the Langmuir wave spectra from SRS are consistent with the saturation by secondary and tertiary decay of the primary SRS Langmuir waves. Scaling laws derived from a local model of SRS saturation are compared with full simulations and recent Nova experiments. (orig.)

  12. An Experimental Study of Roughness-Induced Instabilities in a Supersonic Boundary Layer

    Science.gov (United States)

    Kegerise, Michael A.; King, Rudolph A.; Choudhari, Meelan; Li, Fei; Norris, Andrew

    2014-01-01

    Progress on an experimental study of laminar-to-turbulent transition induced by an isolated roughness element in a supersonic laminar boundary layer is reported in this paper. Here, the primary focus is on the effects of roughness planform shape on the instability and transition characteristics. Four different roughness planform shapes were considered (a diamond, a circle, a right triangle, and a 45 degree fence) and the height and width of each one was held fixed so that a consistent frontal area was presented to the oncoming boundary layer. The nominal roughness Reynolds number was 462 and the ratio of the roughness height to the boundary layer thickness was 0.48. Detailed flow- field surveys in the wake of each geometry were performed via hot-wire anemometry. High- and low-speed streaks were observed in the wake of each roughness geometry, and the modified mean flow associated with these streak structures was found to support a single dominant convective instability mode. For the symmetric planform shapes - the diamond and circular planforms - the instability characteristics (mode shapes, growth rates, and frequencies) were found to be similar. For the asymmetric planform shapes - the right-triangle and 45 degree fence planforms - the mode shapes were asymmetrically distributed about the roughness-wake centerline. The instability growth rates for the asymmetric planforms were lower than those for the symmetric planforms and therefore, transition onset was delayed relative to the symmetric planforms.

  13. Radiation-induced genomic instability, and the cloning and functional analysis of its related gene

    International Nuclear Information System (INIS)

    Muto, Masahiro; Kanari, Yasuyoshi; Kubo, Eiko; Yamada, Yutaka

    2000-01-01

    Exposure to ionizing radiation produces a number of biological consequences including gene mutations, chromosome aberrations, cellular transformation and cell death. The classical view has been that mutations occur at the sites of DNA damage, that is, damage produced by radiation is converted into a mutation during subsequent DNA replication or as a consequence of enzymatic repair processes. However, many investigators have presented evidence for an alternative mechanism to explain these biological effects. This evidence suggests that radiation may induce a process of genomic instability that is transmissible over many generations of cell replication and that serves to enhance the probability of the occurrence of such genetic effects among the progeny of the irradiated cell after many generations of cell replication. If such a process exists in vivo, it could have significant implications for mechanisms of carcinogenesis. Exposure of B10 mice to fractionated X-irradiation induces a high incidence of thymic lymphomas, whereas the incidence in STS/A mice is very low. Such strain differences are presumably determined genetically, and various genetic factors have been reported to be involved in radiation-induced lymphomagenesis. The mechanism of radiation-induced lymphomagenesis appears to develop through a complex and multistep process. Using this experimental system, we characterized the prelymphoma cells induced by radiation, and identified the genetic changes preceding the development of thymic lymphomas by comparing the oncogenic alterations with the pattern of T cell receptor (TCR) γ rearrangements. In these studies, the latent expression of some chromosomal aberrations and p53 mutations in irradiated progeny has been interpreted to be a manifestation of genomic instability. In the present report we review the results of in vivo studies conducted in our laboratory that support the hypothesis of genomic instability induced by radiation, and we describe the

  14. Moisture-induced solid state instabilities in α-chymotrypsin and their reduction through chemical glycosylation

    Directory of Open Access Journals (Sweden)

    Solá Ricardo J

    2010-08-01

    Full Text Available Abstract Background Protein instability remains the main factor limiting the development of protein therapeutics. The fragile nature (structurally and chemically of proteins makes them susceptible to detrimental events during processing, storage, and delivery. To overcome this, proteins are often formulated in the solid-state which combines superior stability properties with reduced operational costs. Nevertheless, solid protein pharmaceuticals can also suffer from instability problems due to moisture sorption. Chemical protein glycosylation has evolved into an important tool to overcome several instability issues associated with proteins. Herein, we employed chemical glycosylation to stabilize a solid-state protein formulation against moisture-induced deterioration in the lyophilized state. Results First, we investigated the consequences of moisture sorption on the stability and structural conformation of the model enzyme α-chymotrypsin (α-CT under controlled humidity conditions. Results showed that α-CT aggregates and inactivates as a function of increased relative humidity (RH. Furthermore, α-CT loses its native secondary and tertiary structure rapidly at increasing RH. In addition, H/D exchange studies revealed that α-CT structural dynamics increased at increasing RH. The magnitude of the structural changes in tendency parallels the solid-state instability data (i.e., formation of buffer-insoluble aggregates, inactivation, and loss of native conformation upon reconstitution. To determine if these moisture-induced instability issues could be ameliorated by chemical glycosylation we proceeded to modify our model protein with chemically activated glycans of differing lengths (lactose and dextran (10 kDa. The various glycoconjugates showed a marked decrease in aggregation and an increase in residual activity after incubation. These stabilization effects were found to be independent of the glycan size. Conclusion Water sorption leads to

  15. Genomic instability induced by 60Co γ ray radiation in normal human liver cells

    International Nuclear Information System (INIS)

    Gen Xiaohua; Guo Xianhua; Zuo Yahui; Wang Xiaoli; Wang Zhongwen

    2007-01-01

    Objective: To explore the genomic instability induced by 60 Co γ rays. Methods: The cloning efficiency and micronucleus efficiency of normal human liver cell irradiated by 60 Co γ rays were detected, and the method of single cell gel electrophoresis (SCGE) was carried out to measure DNA chains damage. The fast-growing cells were divided into different dose-groups and then irradiated by 60 Co γ rays. After 40 populations doubling, the progenies were secondly irradiated with 2 Gy 60 Co γ rays. Results: The cloning efficiency decreased with the increase of doses after the initial irradiation. After the survival cells were given second irradiation, both results of SCGE and micronucleus frequency showed that the second damage was correlated with the original irradiation doses. Conclusions: 60 Co γ rays can not only induce the immediate biological effects in liver cells, but also lead to the genomic instability in the descendants that leads to an enhanced frequency of genetic changes occurring among the progeny of the original irradiated cell. The expanding effect of second event helps to study the genomic instability. (authors)

  16. Perspectives on the role of bystander effect and genomic instability on therapy-induced secondary malignancy

    International Nuclear Information System (INIS)

    Perumal, Venkatachalam; Raavi, Venkateswarlu; Kanagaraj, Karthik; Shangamithra, V.; Paul, Solomon F.D.; Chinnadurai, M.

    2017-01-01

    Deviation from the orchestra of regulated cell division into unregulated and then result into the formation of tumor, is known as carcinogenesis. While causes and hallmarks of many cancer types are well established, newer concepts on tumor cell response to treatment, challenges established therapeutic regime and drives into alternative toward the better management. The phenomena of therapeutics induced bystander response, and genomic instability on late effects of cancer therapy is emerging as a newer challenge. Bystander response is defined as the manifestation of radiation/chemotherapy drug signatures on the unexposed cells which are in the closer vicinity of the directly exposed; on the other hand, genomic instability is defined as the expression of radiation/chemotherapy drug signatures in the progeny of exposed cells. Unequivocally, existence of those phenomena has been demonstrated with many cell types (both in vitro and in vivo) followed by radiation and widely used chemotherapeutic drugs. Nevertheless, it is also revealed that the effects are variable and depend on dose, type of radiation/chemicals agents, experimental model, type of donor and recipient cells, and biomarkers adopted; moreover, to observe those effects, reactive oxygen species has been reported as leading mediators of those responses when compared to other molecules such as interleukins, cytokines, and inflammatory markers. Available data on those phenomena and our findings suggest that a role of therapeutic drugs induced bystander effects, and genomic instability on the development of secondary malignancy cannot be ruled out completely. (author)

  17. Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells

    DEFF Research Database (Denmark)

    Machado, Ana Manuel Dantas; Figueiredo, Ceu; Touati, Eliette

    2009-01-01

    of genetic instabilities in the nuclear and mitochondrial DNA (mtDNA) were examined. EXPERIMENTAL DESIGN: We observed the effects of H. pylori infection on a gastric cell line (AGS), on C57BL/6 mice, and on individuals with chronic gastritis. In AGS cells, the effect of H. pylori infection on base excision...... cells and chronic gastritis tissue were determined by PCR, single-stranded conformation polymorphism, and sequencing. H. pylori vacA and cagA genotyping was determined by multiplex PCR and reverse hybridization. RESULTS: Following H. pylori infection, the activity and expression of base excision repair...... and MMR are down-regulated both in vitro and in vivo. Moreover, H. pylori induces genomic instability in nuclear CA repeats in mice and in mtDNA of AGS cells and chronic gastritis tissue, and this effect in mtDNA is associated with bacterial virulence. CONCLUSIONS: Our results suggest that H. pylori...

  18. Mass-induced instability of SAdS black hole in Einstein-Ricci cubic gravity

    Science.gov (United States)

    Myung, Yun Soo

    2018-05-01

    We perform the stability analysis of Schwarzschild-AdS (SAdS) black hole in the Einstein-Ricci cubic gravity. It shows that the Ricci tensor perturbations exhibit unstable modes for small black holes. We call this the mass-induced instability of SAdS black hole because the instability of small black holes arises from the massiveness in the linearized Einstein-Ricci cubic gravity, but not a feature of higher-order derivative theory giving ghost states. Also, we point out that the correlated stability conjecture holds for the SAdS black hole by computing the Wald entropy of SAdS black hole in Einstein-Ricci cubic gravity.

  19. Modulational instability for an induced field in the far-wake region of a space vehicle

    International Nuclear Information System (INIS)

    Liao Jingjing; Deng Qian; Qu Wen

    2012-01-01

    The behavior of the induced field and the generation of density cavitons in the far-wake region (|k 0 | → 0) of a space vehicle can be described by a set of nonlinear coupling equations. Modulational instability of the induced field is investigated on the basis of the nonlinear equations. The results show that the induced field is modulationally unstable and will collapse into spatial localized structures; meanwhile, density cavitons will be generated. The characteristic scale and the maximum growth rate of the induced field depend not only on the angle between the amplitude of pump waves E 0 and the perturbation wave vector k, but also on the energy density of pump waves |E 0 | 2 . (paper)

  20. Bystander effects in UV-induced genomic instability: Antioxidants inhibit delayed mutagenesis induced by ultraviolet A and B radiation

    Directory of Open Access Journals (Sweden)

    Dahle Jostein

    2005-01-01

    Full Text Available Abstract Background Genomic instability is characteristic of many types of human cancer. Recently, we reported that ultraviolet radiation induced elevated mutation rates and chromosomal instability for many cell generations after ultraviolet irradiation. The increased mutation rates of unstable cells may allow them to accumulate aberrations that subsequently lead to cancer. Ultraviolet A radiation, which primarily acts by oxidative stress, and ultraviolet B radiation, which initially acts by absorption in DNA and direct damage to DNA, both produced genomically unstable cell clones. In this study, we have determined the effect of antioxidants on induction of delayed mutations by ultraviolet radiation. Delayed mutations are indicative of genomic instability. Methods Delayed mutations in the hypoxanthine phosphoribosyl transferase (hprt gene were detected by incubating the cells in medium selectively killing hprt mutants for 8 days after irradiation, followed by a 5 day period in normal medium before determining mutation frequencies. Results The UVB-induced delayed hprt mutations were strongly inhibited by the antioxidants catalase, reduced glutathione and superoxide dismutase, while only reduced glutathione had a significant effect on UVA-induced delayed mutations. Treatment with antioxidants had only minor effects on early mutation frequenies, except that reduced glutathione decreased the UVB-induced early mutation frequency by 24 %. Incubation with reduced glutathione was shown to significantly increase the intracellular amount of reduced glutathione. Conclusion The strong effects of these antioxidants indicate that genomic instability, which is induced by the fundamentally different ultraviolet A and ultraviolet B radiation, is mediated by reactive oxygen species, including hydrogen peroxide and downstream products. However, cells take up neither catalase nor SOD, while incubation with glutathione resulted in increased intracellular levels of

  1. High speed observation of HIFU-induced cavitation cloud near curved rigid boundaries

    International Nuclear Information System (INIS)

    Zuo, Z G; Wang, F B; Liu, S H; Wu, S J

    2015-01-01

    This paper focuses on the experimental study of the influence of surface curvature to the behaviour of HIFU-induced cavitation cloud. A Q-switched ruby pulse laser is used to induce cavitation nuclei in deionized water. A piezoelectric ultrasonic transducer (1.7 MHz) provides a focused ultrasound field to inspire the nucleus to cavitation cloud. A PZT probe type hydrophone is applied for measuring the HIFU sound field. It was observed that the motion of cavitation cloud located near the boundary is significantly influenced by the distance between cloud and boundary, as well as the curvature of the boundary. The curvature was defined by parameters λ and ξ. Convex boundary, concave boundary, and flat boundary correspond to ξ <1, ξ >1 and ξ = 1, respectively. Different behaviours of the cloud, including the migration of the cloud, the characteristics of oscillation, etc., were observed under different boundary curvatures by high-speed photography. Sonoluminescence of the acoustic cavitation bubble clouds were also studied to illustrate the characteristics of acoustic streaming

  2. Bystander effects, adaptive response and genomic instability induced by prenatal irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Streffer, Christian [Institute for Science and Ethics, University Duisburg-Essen, Auf dem Sutan 12, D-45239 Essen (Germany)]. E-mail: streffer.essen@t-online.de

    2004-12-02

    The developing human embryo and fetus undergo very radiosensitive stages during the prenatal development. It is likely that the induction of low dose related effects such as bystander effects, the adaptive response, and genomic instability would have profound effects on embryonic and fetal development. In this paper, I review what has been reported on the induction of these three phenomena in exposed embryos and fetuses. All three phenomena have been shown to occur in murine embryonic or fetal cells and structures, although the induction of an adaptive response (and also likely the induction of bystander effects) are limited in terms of when during development they can be induced and the dose or dose-rate used to treat animals in utero. In contrast, genomic instability can be induced throughout development, and the effects of radiation exposure on genome instability can be observed for long times after irradiation including through pre- and postnatal development and into the next generation of mice. There are clearly strain-specific differences in the induction of these phenomena and all three can lead to long-term detrimental effects. This is true for the adaptive response as well. While induction of an adaptive response can make fetuses more resistant to some gross developmental defects induced by a subsequent high dose challenge with ionizing radiation, the long-term effects of this low dose exposure are detrimental. The negative effects of all three phenomena reflect the complexity of fetal development, a process where even small changes in the timing of gene expression or suppression can have dramatic effects on the pattern of biological events and the subsequent development of the mammalian organism.

  3. Progress in understanding turbulent mixing induced by Rayleigh-Taylor and Richtmyer-Meshkov instabilities

    International Nuclear Information System (INIS)

    Zhou Ye; Remington, B.A.; Robey, H.F.; Cook, A.W.; Glendinning, S.G.; Dimits, A.; Buckingham, A.C.; Zimmerman, G.B.; Burke, E.W.; Peyser, T.A.; Cabot, W.; Eliason, D.

    2003-01-01

    Turbulent hydrodynamic mixing induced by the Rayleigh-Taylor (RT) and Richtmyer-Meshkov (RM) instabilities occurs in settings as varied as exploding stars (supernovae), inertial confinement fusion (ICF) capsule implosions, and macroscopic flows in fluid dynamics facilities such as shock tubes. Turbulence theory and modeling have been applied to RT and RM induced flows and developed into a quantitative description of turbulence from the onset to the asymptotic end-state. The treatment, based on a combined approach of theory, direct numerical simulation (DNS), and experimental data analysis, has broad generality. Three areas of progress will be reported. First, a robust, easy to apply criteria will be reported for the mixing transition in a time-dependent flow. This allows an assessment of whether flows, be they from supernova explosions or ICF experiments, should be mixed down to the molecular scale or not. Second, through DNS, the structure, scaling, and spectral evolution of the RT instability induced flow will be inspected. Finally, using these new physical insights, a two-scale, dynamic mix model has been developed that can be applied to simulations of ICF experiments and astrophysics situations alike

  4. Persistent genetic instability induced by synergistic interaction between x-irradiation and 6-thioguanine

    International Nuclear Information System (INIS)

    Grosovsky, A.J.; Nelson, S.L.; Smith, L.E.

    1995-01-01

    Clonal karyotypic analysis was performed using G-banding on four groups of clones derived from TK6 human lymphoblasts: 25 HPRT - total gene deletion mutants induced by exposure to 2 Gy of x-rays; 8 spontaneous HPRT - total gene deletion mutants; 25 clones irradiated with 2 Gy, not selected with 6-thioguanine. Ten to twenty metaphases were examined for each clone. Extensive karyotypic heterogeneity was observed among x-ray induced HPRT - mutants involving translocations, deletions, duplications and aneuploidy; recovery of chromosomal aberrations and karyotypic heterogeneity was greater than the additive effects of clones treated with x-irradiation or 6-thioguanine alone. This synergistic interaction between x-irradiation and 6-thioguanine was observed despite a 7 day phenotypic expression interval between exposure to the two agents. Thus, x-irradiated TK6 cells appear to be persistently hypersensitive to the induction of genetic instability. Several mutants appeared to exhibit evidence of clonal evolution since aberrant chromosomes observed in one metaphase, were found to be further modified in other metaphases. In order to determine if genetic instability, identified by clonal karyotypic heterogeneity, affected specific locus mutation rates, we utilized the heterozygous thymidine kinase (tk) locus as a genetic marker. Four x-ray induced HPRT - mutants with extensive karyotypic heterogeneity, exhibited mutation rates at tk ranging from 5 to 8 fold higher than the parental TK6 cells. Further analysis, using fractionated low dose radiation exposure, is currently in progress

  5. Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes

    Directory of Open Access Journals (Sweden)

    Philpott Michael P

    2010-02-01

    Full Text Available Abstract Background The human cell cycle transcription factor FOXM1 is known to play a key role in regulating timely mitotic progression and accurate chromosomal segregation during cell division. Deregulation of FOXM1 has been linked to a majority of human cancers. We previously showed that FOXM1 was upregulated in basal cell carcinoma and recently reported that upregulation of FOXM1 precedes malignancy in a number of solid human cancer types including oral, oesophagus, lung, breast, kidney, bladder and uterus. This indicates that upregulation of FOXM1 may be an early molecular signal required for aberrant cell cycle and cancer initiation. Results The present study investigated the putative early mechanism of UVB and FOXM1 in skin cancer initiation. We have demonstrated that UVB dose-dependently increased FOXM1 protein levels through protein stabilisation and accumulation rather than de novo mRNA expression in human epidermal keratinocytes. FOXM1 upregulation in primary human keratinocytes triggered pro-apoptotic/DNA-damage checkpoint response genes such as p21, p38 MAPK, p53 and PARP, however, without causing significant cell cycle arrest or cell death. Using a high-resolution Affymetrix genome-wide single nucleotide polymorphism (SNP mapping technique, we provided the evidence that FOXM1 upregulation in epidermal keratinocytes is sufficient to induce genomic instability, in the form of loss of heterozygosity (LOH and copy number variations (CNV. FOXM1-induced genomic instability was significantly enhanced and accumulated with increasing cell passage and this instability was increased even further upon exposure to UVB resulting in whole chromosomal gain (7p21.3-7q36.3 and segmental LOH (6q25.1-6q25.3. Conclusion We hypothesise that prolonged and repeated UVB exposure selects for skin cells bearing stable FOXM1 protein causes aberrant cell cycle checkpoint thereby allowing ectopic cell cycle entry and subsequent genomic instability. The aberrant

  6. The general dispersion relation of induced streaming instabilities in quantum outflow systems

    Energy Technology Data Exchange (ETDEWEB)

    Mehdian, H., E-mail: mehdian@khu.ac.ir; Hajisharifi, K.; Hasanbeigi, A. [Department of Physics and Institute for Plasma Research, Kharazmi University, 49 Dr Mofatteh Avenue, Tehran 15614 (Iran, Islamic Republic of)

    2015-11-15

    In this manuscript the dispersion relations of streaming instabilities, by using the unique property (neutralized in charge and current by default) of plasma shells colliding, have been generalized and studied. This interesting property for interpenetrating beams enables one to find the general dispersion relations without any restrictions used in the previous works in this area. In our previous work [H. Mehdian et al., ApJ. 801, 89 (2015)], employing the plasma shell concept and boost frame method, the general dispersion relation for filamentation instability has been derived in the relativistic classical regime. But in this paper, using the above mentioned concepts, the general dispersion relations (for each of streaming instabilities, filamentation, two-stream and multi-stream) in the non-relativistic quantum regime have been derived by employing the quantum fluid equations together with Maxwell equations. The derived dispersion relations enable to describe any arbitrary system of interacting two and three beams, justified neutralization condition, by choosing the inertial reference frame embedded on the one of the beams. Furthermore, by the numerical and analytical study of these dispersion relations, many new features of streaming instabilities (E.g. their cut-off wave numbers and growth rates) in terms of all involved parameters have been illustrated. The obtained results in this paper can be used to describe many astrophysical systems and laboratory astrophysics setting, such as collision of non-parallel plasma shells over a background plasma or the collision of three neutralized plasma slabs, and justifying the many plasma phenomena such as particle accelerations and induced fields.

  7. Pad-mode-induced instantaneous mode instability for simple models of brake systems

    Science.gov (United States)

    Oberst, S.; Lai, J. C. S.

    2015-10-01

    Automotive disc brake squeal is fugitive, transient and remains difficult to predict. In particular, instantaneous mode squeal observed experimentally does not seem to be associated with mode coupling and its mechanism is not clear. The effects of contact pressures, friction coefficients as well as material properties (pressure and temperature dependency and anisotropy) for brake squeal propensity have not been systematically explored. By analysing a finite element model of an isotropic pad sliding on a plate similar to that of a previously reported experimental study, pad modes have been identified and found to be stable using conventional complex eigenvalue analysis. However, by subjecting the model to contact pressure harmonic excitation for a range of pressures and friction coefficients, a forced response analysis reveals that the dissipated energy for pad modes is negative and becomes more negative with increasing contact pressures and friction coefficients, indicating the potential for instabilities. The frequency of the pad mode in the sliding direction is within the range of squeal frequencies observed experimentally. Nonlinear time series analysis of the vibration velocity also confirms the evolution of instabilities induced by pad modes as the friction coefficient increases. By extending this analysis to a more realistic but simple brake model in the form of a pad-on-disc system, in-plane pad-modes, which a complex eigenvalue analysis predicts to be stable, have also been identified by negative dissipated energy for both isotropic and anisotropic pad material properties. The influence of contact pressures on potential instabilities has been found to be more dominant than changes in material properties owing to changes in pressure or temperature. Results here suggest that instantaneous mode squeal is likely caused by in-plane pad-mode instabilities.

  8. Electron cloud and ion effects

    CERN Document Server

    Arduini, Gianluigi

    2002-01-01

    The significant progress in the understanding and control of machine impedances has allowed obtaining beams with increasing brilliance. Dense positively charged beams generate electron clouds via gas ionization, photoemission and multipacting. The electron cloud in turn interacts with the beam and the surrounding environment originating fast coupled and single bunch instabilities, emittance blow-up, additional loads to vacuum and cryogenic systems, perturbation to beam diagnostics and feedbacks and it constitutes a serious limitation to machine performance. In a similar way high brilliance electron beams are mainly affected by positively charged ions produced by residual gas ionization. Recent observations of electron cloud build-up and its effects in present accelerators are reviewed and compared with theory and with the results of state-of-the-art computer simulations. Two-stream instabilities induced by the interaction between electron beams and ions are discussed. The implications for future accelerators ...

  9. Laser-filamentation-induced condensation and snow formation in a cloud chamber.

    Science.gov (United States)

    Ju, Jingjing; Liu, Jiansheng; Wang, Cheng; Sun, Haiyi; Wang, Wentao; Ge, Xiaochun; Li, Chuang; Chin, See Leang; Li, Ruxin; Xu, Zhizhan

    2012-04-01

    Using 1 kHz, 9 mJ femtosecond laser pulses, we demonstrate laser-filamentation-induced spectacular snow formation in a cloud chamber. An intense updraft of warm moist air is generated owing to the continuous heating by the high-repetition filamentation. As it encounters the cold air above, water condensation and large-sized particles spread unevenly across the whole cloud chamber via convection and cyclone like action on a macroscopic scale. This indicates that high-repetition filamentation plays a significant role in macroscopic laser-induced water condensation and snow formation.

  10. Systemic chemotherapy induces microsatellite instability in the peripheral blood mononuclear cells of breast cancer patients

    International Nuclear Information System (INIS)

    Fonseca, Fernando LA; Sant Ana, Aleksandra VL; Bendit, Israel; Arias, Vitor; Costa, Luciano J; Pinhal, Aparecida A; Giglio, Auro del

    2005-01-01

    Systemic chemotherapy is an important part of treatment for breast cancer. We conducted the present study to evaluate whether systemic chemotherapy could produce microsatellite instability (MSI) in the peripheral blood mononuclear cell fraction of breast cancer patients. We studied 119 sequential blood samples from 30 previously untreated breast cancer patients before, during and after chemotherapy. For comparison, we also evaluated 20 women who had no relevant medical history (control group). In 27 out of 30 patients we observed MSI in at least one sample, and six patients had loss of heterozygosity. We found a significant correlation between the number of MSI events per sample and chemotherapy with alkylating agents (P < 0.0001). We also observed an inverse correlation between the percentage of cells positive for hMSH2 and the number of MSI events per sample (P = 0.00019) and use of alkylating agents (P = 0.019). We conclude that systemic chemotherapy may induce MSI and loss of heterozygosity in peripheral blood mononuclear cells from breast cancer patients receiving alkylating agents, possibly mediated by a chemotherapy-induced decrease in the expression of hMSH2. These effects may be related to the generation of secondary leukaemia in some patients, and may also intensify the genetic instability of tumours and increase resistance to treatment

  11. Visible-light-induced instability in amorphous metal-oxide based TFTs for transparent electronics

    Directory of Open Access Journals (Sweden)

    Tae-Jun Ha

    2014-10-01

    Full Text Available We investigate the origin of visible-light-induced instability in amorphous metal-oxide based thin film transistors (oxide-TFTs for transparent electronics by exploring the shift in threshold voltage (Vth. A large hysteresis window in amorphous indium-gallium-zinc-oxide (a-IGZO TFTs possessing large optical band-gap (≈3 eV was observed in a visible-light illuminated condition whereas no hysteresis window was shown in a dark measuring condition. We also report the instability caused by photo irradiation and prolonged gate bias stress in oxide-TFTs. Larger Vth shift was observed after photo-induced stress combined with a negative gate bias than the sum of that after only illumination stress and only negative gate bias stress. Such results can be explained by trapped charges at the interface of semiconductor/dielectric and/or in the gate dielectric which play a role in a screen effect on the electric field applied by gate voltage, for which we propose that the localized-states-assisted transitions by visible-light absorption can be responsible.

  12. Visible-light-induced instability in amorphous metal-oxide based TFTs for transparent electronics

    Energy Technology Data Exchange (ETDEWEB)

    Ha, Tae-Jun [Department of Electronic Materials Engineering, Kwangwoon University, Seoul 139-701 (Korea, Republic of)

    2014-10-15

    We investigate the origin of visible-light-induced instability in amorphous metal-oxide based thin film transistors (oxide-TFTs) for transparent electronics by exploring the shift in threshold voltage (V{sub th}). A large hysteresis window in amorphous indium-gallium-zinc-oxide (a-IGZO) TFTs possessing large optical band-gap (≈3 eV) was observed in a visible-light illuminated condition whereas no hysteresis window was shown in a dark measuring condition. We also report the instability caused by photo irradiation and prolonged gate bias stress in oxide-TFTs. Larger V{sub th} shift was observed after photo-induced stress combined with a negative gate bias than the sum of that after only illumination stress and only negative gate bias stress. Such results can be explained by trapped charges at the interface of semiconductor/dielectric and/or in the gate dielectric which play a role in a screen effect on the electric field applied by gate voltage, for which we propose that the localized-states-assisted transitions by visible-light absorption can be responsible.

  13. Non-thermal plasma instabilities induced by deformation of the electron energy distribution function

    Science.gov (United States)

    Dyatko, N. A.; Kochetov, I. V.; Napartovich, A. P.

    2014-08-01

    Non-thermal plasma is a key component in gas lasers, microelectronics, medical applications, waste gas cleaners, ozone generators, plasma igniters, flame holders, flow control in high-speed aerodynamics and others. A specific feature of non-thermal plasma is its high sensitivity to variations in governing parameters (gas composition, pressure, pulse duration, E/N parameter). This sensitivity is due to complex deformations of the electron energy distribution function (EEDF) shape induced by variations in electric field strength, electron and ion number densities and gas excitation degree. Particular attention in this article is paid to mechanisms of instabilities based on non-linearity of plasma properties for specific conditions: gas composition, steady-state and decaying plasma produced by the electron beam, or by an electric current pulse. The following effects are analyzed: the negative differential electron conductivity; the absolute negative electron mobility; the stepwise changes of plasma properties induced by the EEDF bi-stability; thermo-current instability and the constriction of the glow discharge column in rare gases. Some of these effects were observed experimentally and some of them were theoretically predicted and still wait for experimental confirmation.

  14. Investigation of flashing-induced instabilities at Circus test facility with the code ATHLET

    Energy Technology Data Exchange (ETDEWEB)

    Schafer, F.; Manera, A. [Forschungzentrum Rossendorf e.V., Institute of Safety Research, P.O. Box 510119, D-01314 Dresden (Germany)]. E-mail: F.Schaefer@fz-rossendorf.de; A.Manera@fz-rossendorf.de

    2006-07-01

    The test facility CIRCUS (CIRculation Under Start-up) was built to study the start-up phase of a natural-circulation BWR. During the start-up,so-called flashing-induced instabilities can arise. These instabilities are induced by flashing (i.e., steam production in adiabatic conditions) of the coolant in the long riser section, which is placed above the core to enhance the flow rate. The flashing that occurs in the riser causes an imbalance between driving force and pressure losses in the natural-circulation loop, giving rise to flow oscillations. Within the European-Union 5th Framework Programme, a project, NACUSP (Natural circulation and stability performance of BWRs), has been started in December 2000, having as one of its main aims the understanding of the physics of the phenomena involved during the start-up phase of natural-circulation-cooled BWRs, providing a large experimental database and validating state-of-the-art thermo-hydraulic codes in the low-pressure, low-power operational region of these reactors. One part of this project deals with the modelling of selected CIRCUS tests using the thermo-hydraulic code ATHLET (Analysis of THermal-hydraulics of LEaks and Transients). This paper gives an overview about experiments and simulations. The code ATHLET is used to investigate the dynamic behaviour of the CIRCUS test facility and the results of the calculations are compared with the experimental data. (author)

  15. Genomic instability in rat: Breakpoints induced by ionising radiation and interstitial telomeric-like sequences

    International Nuclear Information System (INIS)

    Camats, Nuria; Ruiz-Herrera, Aurora; Parrilla, Juan Jose; Acien, Maribel; Paya, Pilar; Giulotto, Elena; Egozcue, Josep; Garcia, Francisca; Garcia, Montserrat

    2006-01-01

    The Norwegian rat (Rattus norvegicus) is the most widely studied experimental species in biomedical research although little is known about its chromosomal structure. The characterisation of possible unstable regions of the karyotype of this species would contribute to the better understanding of its genomic architecture. The cytogenetic effects of ionising radiation have been widely used for the study of genomic instability, and the importance of interstitial telomeric-like sequences (ITSs) in instability of the genome has also been reported in previous studies in vertebrates. In order to describe the unstable chromosomal regions of R. norvegicus, the distribution of breakpoints induced by X-irradiation and ITSs in its karyotype were analysed in this work. For the X-irradiation analysis, 52 foetuses (from 14 irradiated rats) were studied, 4803 metaphases were analysed, and a total of 456 breakpoints induced by X-rays were detected, located in 114 chromosomal bands, with 25 of them significantly affected by X-irradiation (hot spots). For the analysis of ITSs, three foetuses (from three rats) were studied, 305 metaphases were analysed and 121 ITSs were detected, widely distributed in the karyotype of this species. Seventy-six percent of all hot spots analysed in this study were co-localised with ITSs

  16. Genomic instability in rat: Breakpoints induced by ionising radiation and interstitial telomeric-like sequences

    Energy Technology Data Exchange (ETDEWEB)

    Camats, Nuria [Institut de Biotecnologia i Biomedicina (IBB), Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Departament de Biologia Cel.lular, Fisiologia i Immunologia Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Ruiz-Herrera, Aurora [Departament de Biologia Cel.lular, Fisiologia i Immunologia Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Parrilla, Juan Jose [Servicio de Ginecologia y Obstetricia, Hospital Universitario Virgen de la Arrixaca, Ctra, Madrid-Cartagena, s/n, El Palmar, 30120 Murcia (Spain); Acien, Maribel [Servicio de Ginecologia y Obstetricia, Hospital Universitario Virgen de la Arrixaca, Ctra, Madrid-Cartagena, s/n, El Palmar, 30120 Murcia (Spain); Paya, Pilar [Servicio de Ginecologia y Obstetricia, Hospital Universitario Virgen de la Arrixaca, Ctra, Madrid-Cartagena, s/n, El Palmar, 30120 Murcia (Spain); Giulotto, Elena [Dipartimento di Genetica e Microbiologia Adriano Buzzati Traverso, Universita degli Studi di Pavia, 27100 Pavia (Italy); Egozcue, Josep [Departament de Biologia Cel.lular, Fisiologia i Immunologia Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Garcia, Francisca [Institut de Biotecnologia i Biomedicina (IBB), Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Garcia, Montserrat [Institut de Biotecnologia i Biomedicina (IBB), Universitat Autonoma de Barcelona, 08193 Barcelona (Spain) and Departament de Biologia Cellular, Fisiologia i Immunologia Universitat Autonoma de Barcelona, 08193 Barcelona (Spain)]. E-mail: Montserrat.Garcia.Caldes@uab.es

    2006-03-20

    The Norwegian rat (Rattus norvegicus) is the most widely studied experimental species in biomedical research although little is known about its chromosomal structure. The characterisation of possible unstable regions of the karyotype of this species would contribute to the better understanding of its genomic architecture. The cytogenetic effects of ionising radiation have been widely used for the study of genomic instability, and the importance of interstitial telomeric-like sequences (ITSs) in instability of the genome has also been reported in previous studies in vertebrates. In order to describe the unstable chromosomal regions of R. norvegicus, the distribution of breakpoints induced by X-irradiation and ITSs in its karyotype were analysed in this work. For the X-irradiation analysis, 52 foetuses (from 14 irradiated rats) were studied, 4803 metaphases were analysed, and a total of 456 breakpoints induced by X-rays were detected, located in 114 chromosomal bands, with 25 of them significantly affected by X-irradiation (hot spots). For the analysis of ITSs, three foetuses (from three rats) were studied, 305 metaphases were analysed and 121 ITSs were detected, widely distributed in the karyotype of this species. Seventy-six percent of all hot spots analysed in this study were co-localised with ITSs.

  17. Grain Boundary Induced Bias Instability in Soluble Acene-Based Thin-Film Transistors

    Science.gov (United States)

    Nguyen, Ky V.; Payne, Marcia M.; Anthony, John E.; Lee, Jung Hun; Song, Eunjoo; Kang, Boseok; Cho, Kilwon; Lee, Wi Hyoung

    2016-01-01

    Since the grain boundaries (GBs) within the semiconductor layer of organic field-effect transistors (OFETs) have a strong influence on device performance, a substantial number of studies have been devoted to controlling the crystallization characteristics of organic semiconductors. We studied the intrinsic effects of GBs within 5,11-bis(triethylsilylethynyl) anthradithiophene (TES-ADT) thin films on the electrical properties of OFETs. The GB density was easily changed by controlling nulceation event in TES-ADT thin films. When the mixing time was increased, the number of aggregates in as-spun TES-ADT thin films were increased and subsequent exposure of the films to 1,2-dichloroethane vapor led to a significant increase in the number of nuleation sites, thereby increasing the GB density of TES-ADT spherulites. The density of GBs strongly influences the angular spread and crystallographic orientation of TES-ADT spherulites. Accordingly, the FETs with higher GB densities showed much poorer electrical characteristics than devices with lower GB density. Especially, GBs provide charge trapping sites which are responsible for bias-stress driven electrical instability. Dielectric surface treatment with a polystyrene brush layer clarified the GB-induced charge trapping by reducing charge trapping at the semiconductor-dielectric interface. Our study provides an understanding on GB induced bias instability for the development of high performance OFETs. PMID:27615358

  18. Trans-generational radiation-induced chromosomal instability in the female enhances the action of chemical mutagens

    International Nuclear Information System (INIS)

    Camats, Nuria; Garcia, Francisca; Parrilla, Juan Jose; Calaf, Joaquim; Martin, Miguel; Caldes, Montserrat Garcia

    2008-01-01

    Genomic instability can be produced by ionising radiation, so-called radiation-induced genomic instability, and chemical mutagens. Radiation-induced genomic instability occurs in both germinal and somatic cells and also in the offspring of irradiated individuals, and it is characterised by genetic changes including chromosomal rearrangements. The majority of studies of trans-generational, radiation-induced genomic instability have been described in the male germ line, whereas the authors who have chosen the female as a model are scarce. The aim of this work is to find out the radiation-induced effects in the foetal offspring of X-ray-treated female rats and, at the same time, the possible impact of this radiation-induced genomic instability on the action of a chemical mutagen. In order to achieve both goals, the quantity and quality of chromosomal damage were analysed. In order to detect trans-generational genomic instability, a total of 4806 metaphases from foetal tissues from the foetal offspring of X-irradiated female rats (5 Gy, acute dose) were analysed. The study's results showed that there is radiation-induced genomic instability: the number of aberrant metaphases and the breaks per total metaphases studied increased and were found to be statistically significant (p ≤ 0.05), with regard to the control group. In order to identify how this trans-generational, radiation-induced chromosomal instability could influence the chromosomal behaviour of the offspring of irradiated rat females in front of a chemical agent (aphidicolin), a total of 2481 metaphases were studied. The observed results showed that there is an enhancement of the action of the chemical agent: chromosomal breaks per aberrant metaphases show significant differences (p ≤ 0.05) in the X-ray- and aphidicolin-treated group as regards the aphidicolin-treated group. In conclusion, our findings indicate that there is trans-generational, radiation-induced chromosomal instability in the foetal cells

  19. Trans-generational radiation-induced chromosomal instability in the female enhances the action of chemical mutagens

    Energy Technology Data Exchange (ETDEWEB)

    Camats, Nuria [Institut de Biotecnologia i Biomedicina (IBB), Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Departament de Biologia Cel.lular, Fisiologia i Immunologia, Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Garcia, Francisca [Institut de Biotecnologia i Biomedicina (IBB), Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Parrilla, Juan Jose [Servicio de Ginecologia y Obstetricia, Hospital Universitario Virgen de la Arrixaca, 30120 El Palmar, Murcia (Spain); Calaf, Joaquim [Servei de Ginecologia i Obstetricia, Hospital Universitari de la Santa Creu i Sant Pau, 08025 Barcelona (Spain); Martin, Miguel [Departament de Pediatria, d' Obstetricia i Ginecologia i de Medicina Preventiva, Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Caldes, Montserrat Garcia [Institut de Biotecnologia i Biomedicina (IBB), Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Departament de Biologia Cel.lular, Fisiologia i Immunologia, Universitat Autonoma de Barcelona, 08193 Barcelona (Spain)], E-mail: Montserrat.Garcia.Caldes@uab.es

    2008-04-02

    Genomic instability can be produced by ionising radiation, so-called radiation-induced genomic instability, and chemical mutagens. Radiation-induced genomic instability occurs in both germinal and somatic cells and also in the offspring of irradiated individuals, and it is characterised by genetic changes including chromosomal rearrangements. The majority of studies of trans-generational, radiation-induced genomic instability have been described in the male germ line, whereas the authors who have chosen the female as a model are scarce. The aim of this work is to find out the radiation-induced effects in the foetal offspring of X-ray-treated female rats and, at the same time, the possible impact of this radiation-induced genomic instability on the action of a chemical mutagen. In order to achieve both goals, the quantity and quality of chromosomal damage were analysed. In order to detect trans-generational genomic instability, a total of 4806 metaphases from foetal tissues from the foetal offspring of X-irradiated female rats (5 Gy, acute dose) were analysed. The study's results showed that there is radiation-induced genomic instability: the number of aberrant metaphases and the breaks per total metaphases studied increased and were found to be statistically significant (p {<=} 0.05), with regard to the control group. In order to identify how this trans-generational, radiation-induced chromosomal instability could influence the chromosomal behaviour of the offspring of irradiated rat females in front of a chemical agent (aphidicolin), a total of 2481 metaphases were studied. The observed results showed that there is an enhancement of the action of the chemical agent: chromosomal breaks per aberrant metaphases show significant differences (p {<=} 0.05) in the X-ray- and aphidicolin-treated group as regards the aphidicolin-treated group. In conclusion, our findings indicate that there is trans-generational, radiation-induced chromosomal instability in the foetal

  20. Explosion-induced combustion of hydrocarbon clouds in a chamber

    International Nuclear Information System (INIS)

    Neuwald, P; Reichenbach, H; Kuhl, A L

    2001-01-01

    The interaction of the detonation of a solid HE-charge with a non-premixed cloud of hydro-carbon fuel in a chamber was studied in laboratory experiments. Soap bubbles filled with a flammable gas were subjected to the blast wave created by the detonation of PETN-charges (0.2 g < mass < 0.5 g). The dynamics of the combustion system were investigated by means of high-speed photography and measurement of the quasi-static chamber pressure

  1. WARBURG EFFECT AND TRANSLOCATION-INDUCED GENOMIC INSTABILITY: TWO YEAST MODELS FOR CANCER CELLS

    Directory of Open Access Journals (Sweden)

    Valentina eTosato

    2013-01-01

    Full Text Available Yeast has been established as an efficient model system to study biological principles underpinning human health. In this review we focus on yeast models covering two aspects of cancer formation and progression i the activity of pyruvate kinase (PK, which recapitulates metabolic features of cancer cells, including the Warburg effect, and ii Bridge-Induced chromosome Translocation (BIT mimicking genome instability in cancer. Saccharomyces cerevisiae is an excellent model to study cancer cell metabolism, as exponentially growing yeast cells exhibit many metabolic similarities with rapidly proliferating cancer cells. The metabolic reconfiguration includes an increase in glucose uptake and fermentation, at the expense of respiration and oxidative phosphorylation (the Warburg effect, and involves a broad reconfiguration of nucleotide and amino acid metabolism. Both in yeast and humans, the regulation of this process seems to have a central player, pyruvate kinase, which is up-regulated in cancer, and to occur mostly on a post-transcriptional and posttranslational basis. Furthermore, BIT allows to generate selectable translocation-derived recombinants (translocants, between any two desired chromosomal locations, in wild-type yeast strains transformed with a linear DNA cassette carrying a selectable marker flanked by two DNA sequences homologous to different chromosomes. Using the Bridge-Induced Translocation system, targeted non-reciprocal translocations in mitosis are easily inducible. An extensive collection of different yeast translocants exhibiting genome instability and aberrant phenotypes similar to cancer cells has been produced and subjected to analysis. In this review, we hence provide an overview upon two yeast cancer models, and extrapolate general principles for mimicking human disease mechanisms in yeast.

  2. Potential for supernova-induced chemical enrichment of protoglobular cluster clouds

    International Nuclear Information System (INIS)

    Dopita, M.A.; Smith, G.H.; Dominion Astrophysical Observatory, Victoria, Canada)

    1986-01-01

    This paper seeks to explain the large internal abundance variations that are seen in the globular cluster Omega Cen in terms of supernova-induced chemical enrichment that occurred when the cluster was still largely in a gaseous phase and star formation was continuing. Using a simple power-law density model of this protoglobular gas cloud, the conditions under which this can occur have been established analytically. Clouds less massive than about 100,000 solar masses are completely disrupted by supernova explosions in their adiabatic phase. In clouds of greater mass, supernova explosions occurring near the tidal radius tend to lose their hot gas and metals to the intercloud medium. For explosions occurring closer to the mass center the ejecta must be slowed below the escape velocity, and this can only occur in clouds more massive than about 3 x 10 to the 6th solar masses. If this condition is met, then the slow isothermal momentum-conserving shocks generated by the supernova explosions may eventually induce secondary star formation. For such shocks converging on the mass center, it is found that a cloud mass of at least 10 to the 7th solar masses is required for this process to be efficient. From the observed properties of Omega Cen, a primordial mass of order 10 to the 8th solar masses is estimated, which emphasizes the unusual character of this object. 39 references

  3. Radiation-induced genomic instability is associated with DNA methylation changes in cultured human keratinocytes

    International Nuclear Information System (INIS)

    Kaup, Sahana; Grandjean, Valerie; Mukherjee, Rajarshi; Kapoor, Aparna; Keyes, Edward; Seymour, Colin B.; Mothersill, Carmel E.; Schofield, Paul N.

    2006-01-01

    The mechanism by which radiation-induced genomic instability is initiated, propagated and effected is currently under intense scrutiny. We have investigated the potential role of altered genomic methylation patterns in the cellular response to irradiation and have found evidence for widespread dysregulation of CpG methylation persisting up to 20 population doublings post-irradiation. Similar effects are seen with cells treated with medium from irradiated cells (the 'bystander effect') rather than subjected to direct irradiation. Using an arbitrarily primed methylation sensitive PCR screening method we have demonstrated that irradiation causes reproducible alterations in the methylation profile of a human keratinocyte cell line, HPV-G, and have further characterised one of these sequences as being a member of a retrotransposon element derived sequence family on chromosome 7; MLT1A. Multiple changes were also detected in the screen, which indicate that although the response of cells is predominantly hypermethylation, specific hypomethylation occurs as well. Sequence specific changes are also reported in the methylation of the pericentromeric SAT2 satellite sequence. This is the first demonstration that irradiation results in the induction of heritable methylation changes in mammalian cells, and provides a link between the various non-radiological instigators of genomic instability, the perpetuation of the unstable state and several of its manifestations

  4. Distinct Mechanisms of Nuclease-Directed DNA-Structure-Induced Genetic Instability in Cancer Genomes.

    Science.gov (United States)

    Zhao, Junhua; Wang, Guliang; Del Mundo, Imee M; McKinney, Jennifer A; Lu, Xiuli; Bacolla, Albino; Boulware, Stephen B; Zhang, Changsheng; Zhang, Haihua; Ren, Pengyu; Freudenreich, Catherine H; Vasquez, Karen M

    2018-01-30

    Sequences with the capacity to adopt alternative DNA structures have been implicated in cancer etiology; however, the mechanisms are unclear. For example, H-DNA-forming sequences within oncogenes have been shown to stimulate genetic instability in mammals. Here, we report that H-DNA-forming sequences are enriched at translocation breakpoints in human cancer genomes, further implicating them in cancer etiology. H-DNA-induced mutations were suppressed in human cells deficient in the nucleotide excision repair nucleases, ERCC1-XPF and XPG, but were stimulated in cells deficient in FEN1, a replication-related endonuclease. Further, we found that these nucleases cleaved H-DNA conformations, and the interactions of modeled H-DNA with ERCC1-XPF, XPG, and FEN1 proteins were explored at the sub-molecular level. The results suggest mechanisms of genetic instability triggered by H-DNA through distinct structure-specific, cleavage-based replication-independent and replication-dependent pathways, providing critical evidence for a role of the DNA structure itself in the etiology of cancer and other human diseases. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

  5. Numerical simulation of self-induced rainout using a dynamic convective cloud model

    International Nuclear Information System (INIS)

    Molenkamp, C.R.

    1980-03-01

    The hypothesis that self-induced rainout can occur is supported by observations in Hiroshima and Nagasaki, where deposition of weapons debris with precipitation occurred several km downwind of the burst point. This precipitation was initiated either directly by the nuclear weapons or by the ensuing fires. Simulation of the Nagasaki event with a convection cloud precipitation scavenging model, although fraught with many questionable assumptions, agrees surprisingly well with the observations and supports the hypothesis that self-induced rainout can occur

  6. Radiation and chemotherapy bystander effects induce early genomic instability events: telomere shortening and bridge formation coupled with mitochondrial dysfunction.

    LENUS (Irish Health Repository)

    Gorman, Sheeona

    2012-02-01

    The bridge breakage fusion cycle is a chromosomal instability mechanism responsible for genomic changes. Radiation bystander effects induce genomic instability; however, the mechanism driving this instability is unknown. We examined if radiation and chemotherapy bystander effects induce early genomic instability events such as telomere shortening and bridge formation using a human colon cancer explant model. We assessed telomere lengths, bridge formations, mitochondrial membrane potential and levels of reactive oxygen species in bystander cells exposed to medium from irradiated and chemotherapy-treated explant tissues. Bystander cells exposed to media from 2Gy, 5Gy, FOLFOX treated tumor and matching normal tissue showed a significant reduction in telomere lengths (all p values <0.018) and an increase in bridge formations (all p values <0.017) compared to bystander cells treated with media from unirradiated tissue (0Gy) at 24h. There was no significant difference between 2Gy and 5Gy treatments, or between effects elicited by tumor versus matched normal tissue. Bystander cells exposed to media from 2Gy irradiated tumor tissue showed significant depolarisation of the mitochondrial membrane potential (p=0.012) and an increase in reactive oxygen species levels. We also used bystander cells overexpressing a mitochondrial antioxidant manganese superoxide dismutase (MnSOD) to examine if this antioxidant could rescue the mitochondrial changes and subsequently influence nuclear instability events. In MnSOD cells, ROS levels were reduced (p=0.02) and mitochondrial membrane potential increased (p=0.04). These events were coupled with a decrease in percentage of cells with anaphase bridges and a decrease in the number of cells undergoing telomere length shortening (p values 0.01 and 0.028 respectively). We demonstrate that radiation and chemotherapy bystander responses induce early genomic instability coupled with defects in mitochondrial function. Restoring mitochondrial

  7. Carbon pellet cloud striations

    International Nuclear Information System (INIS)

    Parks, P.B.

    1989-01-01

    Fine scale striations, with alternating rows of bright and dark zones, have been observed in the ablation clouds of carbon pellets injected into the TEXT tokamak. The striations extend along the magnetic field for about 1 cm with quite regular cross-field variations characterized by a wavelength of a few mm. Their potential as a diagnostic tool for measuring q-profiles in tokamaks provides motivation for investigating the origin of the striations. The authors propose that the striations are not due to a sequence of high and low ablation rates because of the finite thermal magnetic islands localized at rational surfaces, q = m/n, would be responsible for reducing the electron flux to the pellet region; the length of the closed field line which forms the local magnetic axis of the island is too long to prevent a depletion of plasma electrons in a flux tube intercepting the pellet for the duration 2 rp / vp . Instead, they propose that striations are the manifestation of the saturated state of growing fluctuations inside the cloud. The instability is generated by E x B rotation of the ablation cloud. The outward centrifugal force points down the ablation density gradient inducing the Rayleigh-Taylor instability. The instability is not present for wave numbers along the field lines, which may explain why the striations are long and uniform in that direction. The E field develops inside the ablation cloud as a result of cold electron return currents which are induced to cancel the incoming hot plasma electron current streaming along the field lines

  8. Instability in time-delayed switched systems induced by fast and random switching

    Science.gov (United States)

    Guo, Yao; Lin, Wei; Chen, Yuming; Wu, Jianhong

    2017-07-01

    In this paper, we consider a switched system comprising finitely or infinitely many subsystems described by linear time-delayed differential equations and a rule that orchestrates the system switching randomly among these subsystems, where the switching times are also randomly chosen. We first construct a counterintuitive example where even though all the time-delayed subsystems are exponentially stable, the behaviors of the randomly switched system change from stable dynamics to unstable dynamics with a decrease of the dwell time. Then by using the theories of stochastic processes and delay differential equations, we present a general result on when this fast and random switching induced instability should occur and we extend this to the case of nonlinear time-delayed switched systems as well.

  9. Back-Analyses of Landfill Instability Induced by High Water Level: Case Study of Shenzhen Landfill

    Directory of Open Access Journals (Sweden)

    Ren Peng

    2016-01-01

    Full Text Available In June 2008, the Shenzhen landfill slope failed. This case is used as an example to study the deformation characteristics and failure mode of a slope induced by high water levels. An integrated monitoring system, including water level gauges, electronic total stations, and inclinometers, was used to monitor the slope failure process. The field measurements suggest that the landfill landslide was caused by a deep slip along the weak interface of the composite liner system at the base of the landfill. The high water level is considered to be the main factor that caused this failure. To calculate the relative interface shear displacements in the geosynthetic multilayer liner system, a series of numerical direct shear tests were carried out. Based on the numerical results, the composite lining system simplified and the centrifuge modeling technique was used to quantitatively evaluate the effect of water levels on landfill instability.

  10. Back-Analyses of Landfill Instability Induced by High Water Level: Case Study of Shenzhen Landfill

    Science.gov (United States)

    Peng, Ren; Hou, Yujing; Zhan, Liangtong; Yao, Yangping

    2016-01-01

    In June 2008, the Shenzhen landfill slope failed. This case is used as an example to study the deformation characteristics and failure mode of a slope induced by high water levels. An integrated monitoring system, including water level gauges, electronic total stations, and inclinometers, was used to monitor the slope failure process. The field measurements suggest that the landfill landslide was caused by a deep slip along the weak interface of the composite liner system at the base of the landfill. The high water level is considered to be the main factor that caused this failure. To calculate the relative interface shear displacements in the geosynthetic multilayer liner system, a series of numerical direct shear tests were carried out. Based on the numerical results, the composite lining system simplified and the centrifuge modeling technique was used to quantitatively evaluate the effect of water levels on landfill instability. PMID:26771627

  11. Warburg effect and translocation-induced genomic instability: two yeast models for cancer cells

    International Nuclear Information System (INIS)

    Tosato, Valentina; Grüning, Nana-Maria; Breitenbach, Michael; Arnak, Remigiusz; Ralser, Markus; Bruschi, Carlo V.

    2013-01-01

    Yeast has been established as an efficient model system to study biological principles underpinning human health. In this review we focus on yeast models covering two aspects of cancer formation and progression (i) the activity of pyruvate kinase (PK), which recapitulates metabolic features of cancer cells, including the Warburg effect, and (ii) chromosome bridge-induced translocation (BIT) mimiking genome instability in cancer. Saccharomyces cerevisiae is an excellent model to study cancer cell metabolism, as exponentially growing yeast cells exhibit many metabolic similarities with rapidly proliferating cancer cells. The metabolic reconfiguration includes an increase in glucose uptake and fermentation, at the expense of respiration and oxidative phosphorylation (the Warburg effect), and involves a broad reconfiguration of nucleotide and amino acid metabolism. Both in yeast and humans, the regulation of this process seems to have a central player, PK, which is up-regulated in cancer, and to occur mostly on a post-transcriptional and post-translational basis. Furthermore, BIT allows to generate selectable translocation-derived recombinants (“translocants”), between any two desired chromosomal locations, in wild-type yeast strains transformed with a linear DNA cassette carrying a selectable marker flanked by two DNA sequences homologous to different chromosomes. Using the BIT system, targeted non-reciprocal translocations in mitosis are easily inducible. An extensive collection of different yeast translocants exhibiting genome instability and aberrant phenotypes similar to cancer cells has been produced and subjected to analysis. In this review, we hence provide an overview upon two yeast cancer models, and extrapolate general principles for mimicking human disease mechanisms in yeast.

  12. Transposable elements as stress adaptive capacitors induce genomic instability in fungal pathogen Magnaporthe oryzae.

    Directory of Open Access Journals (Sweden)

    Sonia Chadha

    Full Text Available A fundamental problem in fungal pathogenesis is to elucidate the evolutionary forces responsible for genomic rearrangements leading to races with fitter genotypes. Understanding the adaptive evolutionary mechanisms requires identification of genomic components and environmental factors reshaping the genome of fungal pathogens to adapt. Herein, Magnaporthe oryzae, a model fungal plant pathogen is used to demonstrate the impact of environmental cues on transposable elements (TE based genome dynamics. For heat shock and copper stress exposed samples, eight TEs belonging to class I and II family were employed to obtain DNA profiles. Stress induced mutant bands showed a positive correlation with dose/duration of stress and provided evidences of TEs role in stress adaptiveness. Further, we demonstrate that genome dynamics differ for the type/family of TEs upon stress exposition and previous reports of stress induced MAGGY transposition has underestimated the role of TEs in M. oryzae. Here, we identified Pyret, MAGGY, Pot3, MINE, Mg-SINE, Grasshopper and MGLR3 as contributors of high genomic instability in M. oryzae in respective order. Sequencing of mutated bands led to the identification of LTR-retrotransposon sequences within regulatory regions of psuedogenes. DNA transposon Pot3 was identified in the coding regions of chromatin remodelling protein containing tyrosinase copper-binding and PWWP domains. LTR-retrotransposons Pyret and MAGGY are identified as key components responsible for the high genomic instability and perhaps these TEs are utilized by M. oryzae for its acclimatization to adverse environmental conditions. Our results demonstrate how common field stresses change genome dynamics of pathogen and provide perspective to explore the role of TEs in genome adaptability, signalling network and its impact on the virulence of fungal pathogens.

  13. Characterization of Axial Inducer Cavitation Instabilities via High Speed Video Recordings

    Science.gov (United States)

    Arellano, Patrick; Peneda, Marinelle; Ferguson, Thomas; Zoladz, Thomas

    2011-01-01

    Sub-scale water tests were undertaken to assess the viability of utilizing high resolution, high frame-rate digital video recordings of a liquid rocket engine turbopump axial inducer to characterize cavitation instabilities. These high speed video (HSV) images of various cavitation phenomena, including higher order cavitation, rotating cavitation, alternating blade cavitation, and asymmetric cavitation, as well as non-cavitating flows for comparison, were recorded from various orientations through an acrylic tunnel using one and two cameras at digital recording rates ranging from 6,000 to 15,700 frames per second. The physical characteristics of these cavitation forms, including the mechanisms that define the cavitation frequency, were identified. Additionally, these images showed how the cavitation forms changed and transitioned from one type (tip vortex) to another (sheet cavitation) as the inducer boundary conditions (inlet pressures) were changed. Image processing techniques were developed which tracked the formation and collapse of cavitating fluid in a specified target area, both in the temporal and frequency domains, in order to characterize the cavitation instability frequency. The accuracy of the analysis techniques was found to be very dependent on target size for higher order cavitation, but much less so for the other phenomena. Tunnel-mounted piezoelectric, dynamic pressure transducers were present throughout these tests and were used as references in correlating the results obtained by image processing. Results showed good agreement between image processing and dynamic pressure spectral data. The test set-up, test program, and test results including H-Q and suction performance, dynamic environment and cavitation characterization, and image processing techniques and results will be discussed.

  14. Warburg effect and translocation-induced genomic instability: two yeast models for cancer cells

    Energy Technology Data Exchange (ETDEWEB)

    Tosato, Valentina [International Centre for Genetic Engineering and Biotechnology, Trieste (Italy); Grüning, Nana-Maria [Cambridge System Biology Center, Department of Biochemistry, University of Cambridge, Cambridge (United Kingdom); Breitenbach, Michael [Division of Genetics, Department of Cell Biology, University of Salzburg, Salzburg (Austria); Arnak, Remigiusz [International Centre for Genetic Engineering and Biotechnology, Trieste (Italy); Ralser, Markus [Cambridge System Biology Center, Department of Biochemistry, University of Cambridge, Cambridge (United Kingdom); Bruschi, Carlo V., E-mail: bruschi@icgeb.org [International Centre for Genetic Engineering and Biotechnology, Trieste (Italy)

    2013-01-18

    Yeast has been established as an efficient model system to study biological principles underpinning human health. In this review we focus on yeast models covering two aspects of cancer formation and progression (i) the activity of pyruvate kinase (PK), which recapitulates metabolic features of cancer cells, including the Warburg effect, and (ii) chromosome bridge-induced translocation (BIT) mimiking genome instability in cancer. Saccharomyces cerevisiae is an excellent model to study cancer cell metabolism, as exponentially growing yeast cells exhibit many metabolic similarities with rapidly proliferating cancer cells. The metabolic reconfiguration includes an increase in glucose uptake and fermentation, at the expense of respiration and oxidative phosphorylation (the Warburg effect), and involves a broad reconfiguration of nucleotide and amino acid metabolism. Both in yeast and humans, the regulation of this process seems to have a central player, PK, which is up-regulated in cancer, and to occur mostly on a post-transcriptional and post-translational basis. Furthermore, BIT allows to generate selectable translocation-derived recombinants (“translocants”), between any two desired chromosomal locations, in wild-type yeast strains transformed with a linear DNA cassette carrying a selectable marker flanked by two DNA sequences homologous to different chromosomes. Using the BIT system, targeted non-reciprocal translocations in mitosis are easily inducible. An extensive collection of different yeast translocants exhibiting genome instability and aberrant phenotypes similar to cancer cells has been produced and subjected to analysis. In this review, we hence provide an overview upon two yeast cancer models, and extrapolate general principles for mimicking human disease mechanisms in yeast.

  15. Onset of Absolute Instability Induced by Viscous Dissipation in the Poiseuille-Darcy-Benard Convection of a Newtonian Fluid

    International Nuclear Information System (INIS)

    Brandão, P V; Alves, L S de B; Barletta, A

    2014-01-01

    The present paper investigates the transition from convective to absolute instability induced by viscous dissipation. As far as the authors are aware, this is the first time such a study is reported in the literature. Its framework is provided by the Poiseuille-Darcy-Benard convection of a Newtonian fluid. We found the same behaviour observed in the absence of viscous dissipation whenever the Gebhart number is smaller than Ge < 0.95, which is the stabilising effect of the cross flow. When 0.95 < Ge < 4.31, weak cross flows still stabilise the onset of absolute instability but stronger cross flows destabilise it. For a stronger viscous dissipation, i.e. Ge > 4.31, the cross flow always destabilises this onset. The latter two conditions create a scenario where viscous dissipation is capable of inducing a transition to absolute instability in the absence of wall heating, i.e. with a zero Rayleigh number

  16. Lack of specificity of chromosome breaks resulting from radiation-induced genomic instability in Chinese hamster cells

    International Nuclear Information System (INIS)

    Trott, K.-R.; Teibe, A.

    1998-01-01

    In V79 Chinese hamster cells, radiation-induced genomic instability results in a persistently increased frequency of micronuclei, dicentric chromosomes and apoptosis and in decreased colony-forming ability. These manifestations of radiation-induced genomic instability may be attributed to an increased rate of chromosome breakage events many generations after irradiation. This chromosomal instability does not seem to be a property which has been inflicted on individual chromosomes at the time of irradiation. Rather, it appears to be secondary to an increased level of non-specific clastogenic factors in the progeny of most if not all irradiated cells. This conclusion is drawn from the observations presented here, that all the chromosomes in surviving V79 cells are involved in the formation of dicentric chromosome aberrations 1 or 2 weeks after irradiation with about equal probability if corrections are made for chromosome length. (orig.)

  17. Universal model of bias-stress-induced instability in inkjet-printed carbon nanotube networks field-effect transistors

    Science.gov (United States)

    Jung, Haesun; Choi, Sungju; Jang, Jun Tae; Yoon, Jinsu; Lee, Juhee; Lee, Yongwoo; Rhee, Jihyun; Ahn, Geumho; Yu, Hye Ri; Kim, Dong Myong; Choi, Sung-Jin; Kim, Dae Hwan

    2018-02-01

    We propose a universal model for bias-stress (BS)-induced instability in the inkjet-printed carbon nanotube (CNT) networks used in field-effect transistors (FETs). By combining two experimental methods, i.e., a comparison between air and vacuum BS tests and interface trap extraction, BS instability is explained regardless of either the BS polarity or ambient condition, using a single platform constituted by four key factors: OH- adsorption/desorption followed by a change in carrier concentration, electron concentration in CNT channel corroborated with H2O/O2 molecules in ambient, charge trapping/detrapping, and interface trap generation. Under negative BS (NBS), the negative threshold voltage shift (ΔVT) is dominated by OH- desorption, which is followed by hole trapping in the interface and/or gate insulator. Under positive BS (PBS), the positive ΔVT is dominated by OH- adsorption, which is followed by electron trapping in the interface and/or gate insulator. This instability is compensated by interface trap extraction; PBS instability is slightly more complicated than NBS instability. Furthermore, our model is verified using device simulation, which gives insights on how much each mechanism contributes to BS instability. Our result is potentially useful for the design of highly stable CNT-based flexible circuits in the Internet of Things wearable healthcare era.

  18. Cloud-Top Entrainment in Stratocumulus Clouds

    Science.gov (United States)

    Mellado, Juan Pedro

    2017-01-01

    Cloud entrainment, the mixing between cloudy and clear air at the boundary of clouds, constitutes one paradigm for the relevance of small scales in the Earth system: By regulating cloud lifetimes, meter- and submeter-scale processes at cloud boundaries can influence planetary-scale properties. Understanding cloud entrainment is difficult given the complexity and diversity of the associated phenomena, which include turbulence entrainment within a stratified medium, convective instabilities driven by radiative and evaporative cooling, shear instabilities, and cloud microphysics. Obtaining accurate data at the required small scales is also challenging, for both simulations and measurements. During the past few decades, however, high-resolution simulations and measurements have greatly advanced our understanding of the main mechanisms controlling cloud entrainment. This article reviews some of these advances, focusing on stratocumulus clouds, and indicates remaining challenges.

  19. Dust vortices, clouds, and jets in nuclear-induced plasmas

    International Nuclear Information System (INIS)

    Vladimirov, V.I.; Deputatova, L.V.; Nefedov, A.P.; Fortov, V.E.; Rykov, V.A.; Khudyakov, A.V.

    2001-01-01

    The collective movement of dust particles in a plasma formed during deceleration of decay products of californium nuclei in neon is investigated experimentally. For the first time, compact vortex structures containing a large number of coagulating dust particles and dense dust clouds evolving in time are observed. Dust formations have clearly defined boundaries and particles in them form ordered liquid-type structures. Under steady-state conditions, dust structures exist from several minutes to hours. An increase in the voltage applied to the high-voltage electrode leads to the formation of dust particle jets. A change in the electric field configuration transforms the structures from one type to another. A strong recombination of electrons and ions at dust particles is observed. The momentum transfer from ions drifting in an external field to gas molecules is studied using the Monte Carlo method. It is shown that the transferred momentum is so large that it may cause a gas flow. The characteristic features of vortex flow in neon and in air are explained

  20. Volcano and ship tracks indicate excessive aerosol-induced cloud water increases in a climate model.

    Science.gov (United States)

    Toll, Velle; Christensen, Matthew; Gassó, Santiago; Bellouin, Nicolas

    2017-12-28

    Aerosol-cloud interaction is the most uncertain mechanism of anthropogenic radiative forcing of Earth's climate, and aerosol-induced cloud water changes are particularly poorly constrained in climate models. By combining satellite retrievals of volcano and ship tracks in stratocumulus clouds, we compile a unique observational dataset and confirm that liquid water path (LWP) responses to aerosols are bidirectional, and on average the increases in LWP are closely compensated by the decreases. Moreover, the meteorological parameters controlling the LWP responses are strikingly similar between the volcano and ship tracks. In stark contrast to observations, there are substantial unidirectional increases in LWP in the Hadley Centre climate model, because the model accounts only for the decreased precipitation efficiency and not for the enhanced entrainment drying. If the LWP increases in the model were compensated by the decreases as the observations suggest, its indirect aerosol radiative forcing in stratocumulus regions would decrease by 45%.

  1. Arsenic-induced Aurora-A activation contributes to chromosome instability and tumorigenesis

    Science.gov (United States)

    Wu, Chin-Han; Tseng, Ya-Shih; Yang, Chao-Chun; Kao, Yu-Ting; Sheu, Hamm-Ming; Liu, Hsiao-Sheng

    2013-11-01

    Arsenic may cause serious environmental pollution and is a serious industrial problem. Depending on the dosage, arsenic may trigger the cells undergoing either proliferation or apoptosis-related cell death. Because of lack of the proper animal model to study arsenic induced tumorigenesis, the accurate risk level of arsenic exposure has not been determined. Arsenic shows genotoxic effect on human beings who uptake water contaminated by arsenic. Chromosome aberration is frequently detected in arsenic exposure-related diseases and is associated with increased oxidative stress and decreased DNA repairing activity, but the underlying mechanism remains elusive. Aurora-A is a mitotic kinase, over-expression of Aurora-A leads to centrosome amplification, chromosomal instability and cell transformation. We revealed that Aurora-A is over-expressed in the skin and bladder cancer patients from blackfoot-disease endemic areas. Our cell line studies reveal that arsenic exposure between 0.5 μM and 1 μM for 2-7 days are able to induce Aurora-A expression and activation based on promoter activity, RNA and protein analysis. Aurora-A overexpression further increases the frequency of unsymmetrical chromosome segregation through centrosome amplification followed by cell population accumulated at S phase in immortalized keratinocyte (HaCaT) and uroepithelial cells (E7). Furthermore, Aurora-A over-expression was sustained for 1-4 weeks by chronic treatment of immortalized bladder and skin cells with NaAsO2. Aurora-A promoter methylation and gene amplification was not detected in the long-term arsenic treated E7 cells. Furthermore, the expression level of E2F1 transcription factor (E2F1) is increased in the presence of arsenic, and arsenic-related Aurora-A over-expression is transcriptionally regulated by E2F1. We further demonstrated that overexpression of Aurora-A and mutant Ha-ras or Aurora-A and mutant p53 may act additively to trigger arsenic-related bladder and skin cancer

  2. The Role of DNA Methylation Changes in Radiation-Induced Transgenerational Genomic Instability and Bystander Effects in cranial irradiated Mice

    Science.gov (United States)

    Zhang, Meng; Sun, Yeqing; Gao, Yinglong; Zhang, Baodong

    Heavy-ion radiation could lead to genome instability in the germline, and therefore to transgenerational genome and epigenome instability in offspring of exposed males. The exact mechanisms of radiation-induced genome instability in directly exposed and in bystander organ remain obscure, yet accumulating evidence points to the role of DNA methylation changes in genome instability development. The potential of localized body-part exposures to affect the germline and thus induce genome and epigenome changes in the progeny has not been studied. To investigate whether or not the paternal cranial irradiation can exert deleterious changes in the protected germline and the offsprings, we studied the alteration of DNA methylation in the shielded testes tissue. Here we report that the localized paternal cranial irradiation results in a significant altered DNA methylation in sperm cells and leads to a profound epigenetic dysregulation in the unexposed progeny conceived 3 months after paternal exposure. The possible molecular mechanisms and biological consequences of the observed changes are discussed. Keywords: Heavy-ion radiation; Transgenerational effect; Genomic Instability Bystander Effects; DNA methylation.

  3. Oxidized low density lipoprotein induced caspase-1 mediated pyroptotic cell death in macrophages: implication in lesion instability?

    Directory of Open Access Journals (Sweden)

    Jing Lin

    Full Text Available BACKGROUND: Macrophage death in advanced lesion has been confirmed to play an important role in plaque instability. However, the mechanism underlying lesion macrophage death still remains largely unknown. METHODS AND RESULTS: Immunohistochemistry showed that caspase-1 activated in advanced lesion and co-located with macrophages and TUNEL positive reaction. In in-vitro experiments showed that ox-LDL induced caspase-1 activation and this activation was required for ox-LDL induced macrophages lysis, IL-1β and IL-18 production as well as DNA fragmentation. Mechanism experiments showed that CD36 and NLRP3/caspase-1/pathway involved in ox-LDL induced macrophage pyroptosis. CONCLUSION: Our study here identified a novel cell death, pyroptosis in ox-LDL induced human macrophage, which may be implicated in lesion macrophages death and play an important role in lesion instability.

  4. Genomic instability induced by 137Cs γ-ray irradiation in CHL surviving cells

    International Nuclear Information System (INIS)

    Yue Jingyin; Liu Bingchen; Wu Hongying; Zhou Jiwen; Mu Chuanjie

    1999-01-01

    Objective: To study in parallel several possible manifestations of instability of surviving CHL cells after irradiation, namely the frequencies of mutation at locus, micronuclei and apoptosis. Methods: The frequencies of mutation at HGPRT locus, micronuclei and apoptosis were assayed at various times in surviving cells irradiated with γ-rays. Results: The surviving cells showed a persistently increased frequency of mutation at the HGPRT locus after irradiation until 53 days. Mutant fraction as high as 10 -4 was scored, tens of times higher than those assayed in control cells studied in parallel. The frequency of bi nucleated cells with micronuclei determined within 24 hours after irradiation increased with dose and reached a peak value of (26.58 +- 2.48)% at 3 Gy, decreasing at higher doses to a plateau around 20%. The micronucleus frequency decreased steeply to about (14.47 +- 2.39)% within the first 3 days post-irradiation, and fluctuated at around 10% up to 56 days post-irradiation. The delayed efficiency of irradiated cells was significantly decreased. The frequency of apoptosis peaked about (24.90 +- 4.72)% at 10 Gy 48 h post-irradiation (γ-ray dose between 3-10 Gy) and then decreased to about 12% within 3 days. It was significantly higher than in control cells until 14 days. Conclusions: It shows that genomic instability induced by radiation can be transmitted to the progeny of surviving cells and may take many forms of expression such as lethal mutation, chromosome aberrations, gene mutation, etc

  5. An analytical study on excitation of nuclear-coupled thermal-hydraulic instability due to seismically induced resonance in BWR

    Energy Technology Data Exchange (ETDEWEB)

    Hirano, Masashi [Japan Atomic Energy Research Institute, Ibaraki-ken (Japan)

    1997-07-01

    This paper describes the results of a scoping study on seismically induced resonance of nuclear-coupled thermal-hydraulic instability in BWRs, which was conducted by using TRAC-BF1 within a framework of a point kinetics model. As a result of the analysis, it is shown that a reactivity insertion could occur accompanied by in-surge of coolant into the core resulted from the excitation of the nuclear-coupled instability by the external acceleration. In order to analyze this phenomenon more in detail, it is necessary to couple a thermal-hydraulic code with a three-dimensional nuclear kinetics code.

  6. The role of radiation types and dose in induced genomic instability

    International Nuclear Information System (INIS)

    Kadhim Munira, A.

    2007-01-01

    Complete text of publication follows. Genomic Instability (GI) is defined as long-term alterations induced by low-dose exposure to a variety of genotoxic agents in mammalian cells that act to increase the 'apparent' spontaneous mutation frequency.GI is a hallmark of tumorigenic progression and is observed in the progeny of irradiated and bystander cells as the delayed and stochastic appearance of de novo chromosomal aberrations, gene mutations and delayed lethal mutations both in vitro and in vivo. It occurs at a frequency several orders of magnitude greater than would be expected for mutation in a single gene, implying that GI is a multigenic phenomenon. The expression of GI can be influenced by genotype, cell type and radiation quality; however the underlying mechanisms are not fully understood. While several studies have demonstrated GI induction by high and low LET radiation, our work on human and mouse primary cell systems has shown significant differences in the capacity to induce GI and the spectrum of alterations depending on LET. These differences might be attributed to differences in radiation track structure, radiation dose and radiation exposure regime (distribution of hit and un hit cells). In this presentation I shall review the role of radiation quality; describe the possible mechanisms underlining the observed differences between radiation type and present results of experiments demonstrating that the dose of low LET radiation might be the most significant factor in determining the role of radiation type in the induction of GI.

  7. RECQL5 Suppresses Oncogenic JAK2-Induced Replication Stress and Genomic Instability

    Directory of Open Access Journals (Sweden)

    Edwin Chen

    2015-12-01

    Full Text Available JAK2V617F is the most common oncogenic lesion in patients with myeloproliferative neoplasms (MPNs. Despite the ability of JAK2V617F to instigate DNA damage in vitro, MPNs are nevertheless characterized by genomic stability. In this study, we address this paradox by identifying the DNA helicase RECQL5 as a suppressor of genomic instability in MPNs. We report increased RECQL5 expression in JAK2V617F-expressing cells and demonstrate that RECQL5 is required to counteract JAK2V617F-induced replication stress. Moreover, RECQL5 depletion sensitizes JAK2V617F mutant cells to hydroxyurea (HU, a pharmacological inducer of replication stress and the most common treatment for MPNs. Using single-fiber chromosome combing, we show that RECQL5 depletion in JAK2V617F mutant cells impairs replication dynamics following HU treatment, resulting in increased double-stranded breaks and apoptosis. Cumulatively, these findings identify RECQL5 as a critical regulator of genome stability in MPNs and demonstrate that replication stress-associated cytotoxicity can be amplified specifically in JAK2V617F mutant cells through RECQL5-targeted synthetic lethality.

  8. Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis

    Directory of Open Access Journals (Sweden)

    Ifigeneia V. Mavragani

    2017-07-01

    Full Text Available Cellular effects of ionizing radiation (IR are of great variety and level, but they are mainly damaging since radiation can perturb all important components of the cell, from the membrane to the nucleus, due to alteration of different biological molecules ranging from lipids to proteins or DNA. Regarding DNA damage, which is the main focus of this review, as well as its repair, all current knowledge indicates that IR-induced DNA damage is always more complex than the corresponding endogenous damage resulting from endogenous oxidative stress. Specifically, it is expected that IR will create clusters of damage comprised of a diversity of DNA lesions like double strand breaks (DSBs, single strand breaks (SSBs and base lesions within a short DNA region of up to 15–20 bp. Recent data from our groups and others support two main notions, that these damaged clusters are: (1 repair resistant, increasing genomic instability (GI and malignant transformation and (2 can be considered as persistent “danger” signals promoting chronic inflammation and immune response, causing detrimental effects to the organism (like radiation toxicity. Last but not least, the paradigm shift for the role of radiation-induced systemic effects is also incorporated in this picture of IR-effects and consequences of complex DNA damage induction and its erroneous repair.

  9. Radiation-induced genomic instability: Are epigenetic mechanisms the missing link?

    Energy Technology Data Exchange (ETDEWEB)

    Aypar, Umut; Morgan, William F.; Baulch, Janet E.

    2011-02-01

    Purpose: This review examines the evidence for the hypothesis that epigenetics are involved in the initiation and perpetuation of radiation-induced genomic instability (RIGI). Conclusion: In addition to the extensively studied targeted effects of radiation, it is now apparent that non-targeted delayed effects such as RIGI are also important post-irradiation outcomes. In RIGI, unirradiated progeny cells display phenotypic changes at delayed times after radiation of the parental cell. RIGI is thought to be important in the process of carcinogenesis, however, the mechanism by which this occurs remains to be elucidated. In the genomically unstable clones developed by Morgan and colleagues, radiation-induced mutations, double-strand breaks, or changes in mRNA levels alone could not account for the initiation or perpetuation of RIGI. Since changes in the DNA sequence could not fully explain the mechanism of RIGI, inherited epigenetic changes may be involved. Epigenetics are known to play an important role in many cellular processes and epigenetic aberrations can lead to carcinogenesis. Recent studies in the field of radiation biology suggest that the changes in methylation patterns may be involved in RIGI. Together these clues have led us to hypothesize that epigenetics may be the missing link in understanding the mechanism behind RIGI.

  10. Folic acid deficiency increases chromosomal instability, chromosome 21 aneuploidy and sensitivity to radiation-induced micronuclei

    International Nuclear Information System (INIS)

    Beetstra, Sasja; Thomas, Philip; Salisbury, Carolyn; Turner, Julie; Fenech, Michael

    2005-01-01

    Folic acid deficiency can lead to uracil incorporation into DNA, hypomethylation of DNA, inefficient DNA repair and increase chromosome malsegregation and breakage. Because ionising radiation increases demand for efficient DNA repair and also causes chromosome breaks we hypothesised that folic acid deficiency may increase sensitivity to radiation-induced chromosome breakage. We tested this hypothesis by using the cytokinesis-block micronucleus assay in 10 day WIL2-NS cell cultures at four different folic acid concentrations (0.2, 2, 20, and 200 nM) that span the 'normal' physiological range in humans. The study showed a significant dose-dependent increase in frequency of binucleated cells with micronuclei and/or nucleoplasmic bridges with decreasing folic acid concentration (P < 0.0001, P = 0.028, respectively). These biomarkers of chromosomal instability were also increased in cells irradiated (1.5 Gy γ-rays) on day 9 relative to un-irradiated controls (P < 0.05). Folic acid deficiency and γ-irradiation were shown to have a significant interactive effect on frequency of cells containing micronuclei (two-way ANOVA, interaction P 0.0039) such that the frequency of radiation-induced micronucleated cells (i.e. after subtracting base-line frequency of un-irradiated controls) increased with decreasing folic acid concentration (P-trend < 0.0001). Aneuploidy of chromosome 21, apoptosis and necrosis were increased by folic acid deficiency but not by ionising radiation. The results of this study show that folate status has an important impact on chromosomal stability and is an important modifying factor of cellular sensitivity to radiation-induced genome damage

  11. Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype

    International Nuclear Information System (INIS)

    Lentini, Laura; Amato, Angela; Schillaci, Tiziana; Di Leonardo, Aldo

    2007-01-01

    Genetic instability is a hallmark of tumours and preneoplastic lesions. The predominant form of genome instability in human cancer is chromosome instability (CIN). CIN is characterized by chromosomal aberrations, gains or losses of whole chromosomes (aneuploidy), and it is often associated with centrosome amplification. Centrosomes control cell division by forming a bipolar mitotic spindle and play an essential role in the maintenance of chromosomal stability. However, whether centrosome amplification could directly cause aneuploidy is not fully established. Also, alterations in genes required for mitotic progression could be involved in CIN. A major candidate is represented by Aurora-A/STK15 that associates with centrosomes and is overexpressed in several types of human tumour. Centrosome amplification were induced by hydroxyurea treatment and visualized by immunofluorescence microscopy. Aurora-A/STK15 ectopic expression was achieved by retroviral infection and puromycin selection in HCT116 tumour cells. Effects of Aurora-A/STK15 depletion on centrosome status and ploidy were determined by Aurora-A/STK15 transcriptional silencing by RNA interference. Changes in the expression levels of some mitotic genes were determined by Real time RT-PCR. We investigated whether amplification of centrosomes and overexpression of Aurora-A/STK15 induce CIN using as a model system a colon carcinoma cell line (HCT116). We found that in HCT116 cells, chromosomally stable and near diploid cells harbouring a MIN phenotype, centrosome amplification induced by hydroxyurea treatment is neither maintained nor induces aneuploidy. On the contrary, ectopic overexpression of Aurora-A/STK15 induced supernumerary centrosomes and aneuploidy. Aurora-A/STK15 transcriptional silencing by RNA interference in cells ectopically overexpressing this kinase promptly decreased cell numbers with supernumerary centrosomes and aneuploidy. Our results show that centrosome amplification alone is not sufficient

  12. Influence of core NA on thermal-induced mode instabilities in high power fiber amplifiers

    International Nuclear Information System (INIS)

    Tao, Rumao; Ma, Pengfei; Wang, Xiaolin; Zhou, Pu; Liu, Zejin

    2015-01-01

    We report on the influence of core NA on thermal-induced mode instabilities (MI) in high power fiber amplifiers. The influence of core NA and the V-parameter on MI has been investigated numerically. It shows that core NA has a larger influence on MI for fibers with a smaller core-cladding-ratio, and the influence of core NA on the threshold is more obvious when the amplifiers are pumped at 915 nm. The dependence of the threshold on the V-parameter revealed that the threshold increases linearly as the V-parameter decreases when the V-parameter is larger than 3.5, and the threshold shows an exponential increase as the V-parameter decreases when the V-parameter is less than 3.5. We also discussed the effect of linewidth on MI, which indicates that the influence of linewidth can be neglected for a linewidth smaller than 1 nm when the fiber core NA is smaller than 0.07 and the fiber length is shorter than 20 m. Fiber amplifiers with different core NA were experimentally analyzed, which agreed with the theoretical predictions. (letter)

  13. Microbunching-instability-induced sidebands in a seeded free-electron laser

    Directory of Open Access Journals (Sweden)

    Zhen Zhang

    2016-05-01

    Full Text Available Measurements of the multishot-averaged, soft x-ray, self-seeding spectrum at the LCLS free-electron laser often have a pedestal-like distribution around the seeded wavelength, which limits the spectral purity and can negatively affect some user applications not employing a post-undulator monochromator. In this paper, we study the origins of such pedestals, focusing on longitudinal phase space modulations produced by the microbunching instability upstream of the free-electron laser (FEL undulator. We show from theory and numerical simulation that both energy and density modulations can induce sidebands in a high-gain, seeded FEL whose fractional strength typically grows as the square of the undulator length. The results place a tight constraint on the longitudinal phase space uniformity of the electron beam for a seeded FEL, possibly requiring the amplitude of long-wavelength modulations to be much smaller than the typical incoherent energy spread if the output sideband power is to remain only a couple percent or less of the amplified seed power.

  14. Motion of Passive Scalar by Elasticity-Induced Instability in Curved Microchannel

    Directory of Open Access Journals (Sweden)

    Xiao-Bin Li

    2014-08-01

    Full Text Available This paper presented a direct numerical simulation (DNS study on the elasticity-induced irregular flow, passive mixing, and scalar evolution in the curvilinear microchannel. The mixing enhancement was achieved at vanishingly low-Reynolds-number chaotic flow raised by elastic instabilities. Along with the mixing process, the passive scalar transportation carried by the flow was greatly affected by the flow structure and the underlying interaction between microstructures of viscoelastic fluid and flow structure itself. The simulations are conducted for a wide range of viscoelasticity. As the elastic effect exceeds the critical value, the flow tends to a chaotic state, while the evolution of scalar gets strong and fast, showing excellent agreement with experimental results. For the temporal changing of scalar gradients, they vary rapidly in the form of isosurfaces, with the shape of “rolls” in the bulk and evolving into “threads” near the wall. That indicates that the flow fields should be related to the deformation of viscoelastic micromolecules. The probability distribution function analysis between micromolecular deformation and flow field deformation shows that the main direction of molecular stretching is perpendicular to the main direction of flow field deformation. It implies they are weakly correlated, due to the confinement of channel wall.

  15. Study of fracture and stress-induced morphological instabilities in polymeric materials

    Science.gov (United States)

    Sabouri-Ghomi, Mohsen

    We study the phenomena of fracture in polymers at the molecular and continuum level. At a molecular level, we study the failure of polymer/polymer interfaces. Our main focus is on a specific mode of failure known as chain pull-out fracture, which is common to weak adhesive junctions, and polymer blends and mixtures. In the case of the interface between incompatible polymers, reinforcement is achieved by adding a block copolymer to the interface. We introduce a microscopic model based on Brownian dynamics to investigate the effect of the polymerization index N, of the block connector chain, on fracture toughness of such reinforced polymeric junctions. We consider the mushroom regime, where connector chains are grafted with low surface density, for the case of large pulling velocity. We find that for short chains the interface fracture toughness depends linearly on the polymerization index N of the connector chains, while for longer chains the dependence becomes N 3/2. We propose a scaling argument, based on the geometry of the initial configuration, that accounts for both short and long chains and the crossover between them. At the continuum level, we study the pattern selection mechanism of finger-like crack growth phenomena in gradient driven growth problems in general, and the structure of stress-induced morphological instabilities in crazing of polymer glasses in particular. We simulate solidification in a narrow channel through the use of a phase-field model with an adaptive grid. By tuning a dimensionless parameter, the Peclet number, we show a continuous crossover from a free dendrite at high Peclet numbers to anisotropic viscous fingering at low Peclet numbers. At low Peclet numbers we find good agreement between our results, theoretical predictions, and experiment, providing the first quantitative test of solvability theory for anisotropic viscous fingers. For high undercoolings, we find new phenomena, a solid forger which satisfies stability and

  16. Radiation-induced genomic instability and bystander effects: related inflammatory-type responses to radiation-induced stress and injury? A review.

    Science.gov (United States)

    Lorimore, S A; Wright, E G

    2003-01-01

    To review studies of radiation responses in the haemopoietic system in the context of radiation-induced genomic instability, bystander effects and inflammatory-type processes. There is considerable evidence that cells that themselves are not exposed to ionizing radiation but are the progeny of cells irradiated many cell divisions previously may express a high frequency of gene mutations, chromosomal aberrations and cell death. These effects are collectively known as radiation-induced genomic instability. A second untargeted effect results in non-irradiated cells exhibiting responses typically associated with direct radiation exposure but occurs as a consequence of contact with irradiated cells or by receiving soluble signals from irradiated cells. These effects are collectively known as radiation-induced bystander effects. Reported effects include increases or decreases in damage-inducible and stress-related proteins; increases or decreases in reactive oxygen species, cell death or cell proliferation, and induction of mutations and chromosome aberrations. This array of responses is reminiscent of effects mediated by cytokines and other similar regulatory factors that may involve, but do not necessarily require, gap junction-mediated transfer, have multiple inducers and a variety of context-dependent consequences in different cell systems. That chromosomal instability in haemopoietic cells can be induced by an indirect bystander-type mechanism both in vitro and in vivo provides a potential link between these two untargeted effects and there are radiation responses in vivo consistent with the microenvironment contributing secondary cell damage as a consequence of an inflammatory-type response to radiation-induced injury. Intercellular signalling, production of cytokines and free radicals are features of inflammatory responses that have the potential for both bystander-mediated and persisting damage as well as for conferring a predisposition to malignancy. The

  17. Laser induced ablatively driven interfacial nonlinear fluid instabilities in multilayer targets

    International Nuclear Information System (INIS)

    Manoranjan Khan; Gupta, M.R.; Mandal, L.K.; Roy, S.; Banerjee, R.

    2010-01-01

    Complete text of publication follows. High power laser driven shock waves in condensed matter have important application for studying equation of state (EOS) and high pressure physics. This is an important phenomenon in fuel compression for Inertial Confinement Fusion (ICF) experiments where multilayer targets of differing shock impedance are interacted by laser induced shocks. The interface between the two fluid becomes unstable when driven by the impulsive force (Richtmyer-Meshkov) due to such a shock wave or a continuously acting force e.g., gravity (Rayleigh-Taylor). In the nonlinear stage, the fluid interface is found to develop structures having finger-like shapes. The structures resemble a bubble (spike) accordingly as a lighter (heavier) fluid pushes in a heavier (lighter) fluid. These effects need to be mitigated for efficient compression in ICF experiment. We have studied the effect of density variation on R-T and R-M instability on the temporal development of nonlinear two fluid interfacial structures like bubble and spike. It is shown that the velocity of bubble or spike decreases leading to stabilization if the density of the fluids leads to lowering of the Atwood number. The Atwood number A = ρ a -ρ b / ρ a +ρ b changes to A* = ρ a *ρ b */ ρ a *ρ b * where ρ* m = ρ m (1-1/γ m ), m = [a,b], assuming ρ a > ρ b . It has been seen that the stabilization or destabilization (depending on the algebraic sign of the gradient) will be proportional to the pressure p 0 at the interface. The set of equation describing the dynamics of the bubbles and spikes in presence of fluid density variation are not analytically integrable in closed form. All the results are derived by numerical methods and are represented and interpreted. Analytical calculations are performed (not presented here) to modify the dynamical boundary condition between the two fluids and we have finally arrived at the following expression for the asymptotic bubble velocity ν b 2 = 2(r

  18. Molecular Mechanisms of Radiation-Induced Genomic Instability in Human Cells

    Energy Technology Data Exchange (ETDEWEB)

    Howard L. Liber; Jeffrey L. Schwartz

    2005-10-31

    There are many different model systems that have been used to study chromosome instability. What is clear from all these studies is that conclusions concerning chromosome instability depend greatly on the model system and instability endpoint that is studied. The model system for our studies was the human B-lymphoblastoid cell line TK6. TK6 was isolated from a spontaneously immortalized lymphoblast culture. Thus there was no outside genetic manipulation used to immortalize them. TK6 is a relatively stable p53-normal immortal cell line (37). It shows low gene and chromosome mutation frequencies (19;28;31). Our general approach to studying instability in TK6 cells has been to isolate individual clones and analyze gene and chromosome mutation frequencies in each. This approach maximizes the possibility of detecting low frequency events that might be selected against in mass cultures.

  19. Effect of magnetic field on ablatively driven Richtmyer-Meshkov instability induced by interfacial nonlinear structure

    International Nuclear Information System (INIS)

    Labakanta Mandal; Banerjee, R.; Roy, S.; Khan, M.; Gupta, M.R.

    2010-01-01

    Complete text of publication follows. In an Inertial Confinement Fusion (ICF) situation, laser driven ablation front of an imploding capsule is subjected to the fluid instabilities like Rayleigh-Taylor (RT), Richtmyer-Meshkov (RM) and Kelvin-Helmholtz (KH) instability. In this case dense core is compressed and accelerated by low density ablating plasma. During this process laser driven shocks interact the interface and hence it becomes unstable due to the formation of nonlinear structure like bubble and spike. The nonlinear structure is called bubble if the lighter fluid pushes inside the heavier fluid and spike, if opposite takes place. R-M instability causes non-uniform compression of ICF fuel pellets and needs to be mitigated. Scientists and researchers are much more interested on RM instability both from theoretical and experimental points of view. In this article, we have presented the analytical expression for the growth rate and velocity for the nonlinear structures due to the effect of magnetic field of fluid using potential flow model. The magnetic field is assumed to be parallel to the plane of two fluid interfaces. If the magnetic field is restricted only to either side of interface the R-M instability can be stabilized or destabilized depending on whether the magnetic pressure on the interface opposes the instability driving shock pressure or acts in the same direction. An interesting result is that if both the fluids are magnetized, interface as well as velocity of bubble and spike will show oscillating stabilization and R-M instability is mitigated. All analytical results are also supported by numerical results. Numerically it is seen that magnetic field above certain minimum value reduces the instability for compression the target in ICF.

  20. Energetic-particle-driven instabilities and induced fast-ion transport in a reversed field pinch

    International Nuclear Information System (INIS)

    Lin, L.; Brower, D. L.; Ding, W. X.; Anderson, J. K.; Capecchi, W.; Eilerman, S.; Forest, C. B.; Koliner, J. J.; Nornberg, M. D.; Reusch, J.; Sarff, J. S.; Liu, D.

    2014-01-01

    Multiple bursty energetic-particle (EP) driven modes with fishbone-like structure are observed during 1 MW tangential neutral-beam injection in a reversed field pinch (RFP) device. The distinguishing features of the RFP, including large magnetic shear (tending to add stability) and weak toroidal magnetic field (leading to stronger drive), provide a complementary environment to tokamak and stellarator configurations for exploring basic understanding of EP instabilities. Detailed measurements of the EP mode characteristics and temporal-spatial dynamics reveal their influence on fast ion transport. Density fluctuations exhibit a dynamically evolving, inboard-outboard asymmetric spatial structure that peaks in the core where fast ions reside. The measured mode frequencies are close to the computed shear Alfvén frequency, a feature consistent with continuum modes destabilized by strong drive. The frequency pattern of the dominant mode depends on the fast-ion species. Multiple frequencies occur with deuterium fast ions compared to single frequency for hydrogen fast ions. Furthermore, as the safety factor (q) decreases, the toroidal mode number of the dominant EP mode transits from n=5 to n=6 while retaining the same poloidal mode number m=1. The transition occurs when the m=1, n=5 wave-particle resonance condition cannot be satisfied as the fast-ion safety factor (q fi ) decreases. The fast-ion temporal dynamics, measured by a neutral particle analyzer, resemble a classical predator-prey relaxation oscillation. It contains a slow-growth phase arising from the beam fueling followed by a rapid drop when the EP modes peak, indicating that the fluctuation-induced transport maintains a stiff fast-ion density profile. The inferred transport rate is strongly enhanced with the onset of multiple EP modes

  1. Radiation-induced genomic instability driven by de novo chromosomal rearrangement hot spots

    International Nuclear Information System (INIS)

    Grosovsky, A.J.; Allen, R.N.; Moore, S.R.

    2003-01-01

    Genomic instability has become generally recognized as a critical contributor to tumor progression by generating the necessary number of genetic alterations required for expression of a clinically significant malignancy. Our study of chromosomal instability investigates the hypothesis that chromosomal rearrangements can generate novel breakage-prone sites, resulting in instability acting predominantly in cis. Here we present an analysis of the karyotypic distribution of instability associated chromosomal rearrangements in TK6 and derivative human lymphoblasts. Karyotypic analysis performed on a total of 455 independent clones included 183 rearrangements distributed among 100 separate unstable clones. The results demonstrate that the breakpoints of chromosomal rearrangements in unstable clones are non-randomly distributed throughout the genome. This pattern is statistically significant, and incompatible with expectations for random breakage associated with loss or alteration of a trans-acting factor. Furthermore, specific chromosomal breakage hot spots associated with instability have been identified; these occur in several independent unstable clones and are often repeatedly broken and rejoined during the outgrowth of an individual clone. In complimentary studies, genomic instability was generated without any exposure to a DNA-damaging agent, but rather by transfection with alpha heterochromatin DNA. In a prospective analysis, human-hamster hybrid AL cells containing a single human chromosome 11 were transfected with heterochromatic alpha DNA repeats and clones were analyzed by chromosome 11 painting. Transfection with alpha DNA was associated with karyotypic heterogeneity in 40% of clones examined; control transfections with plasmid alone did not lead to karyotypic heterogeneity

  2. Progress in Studies of Electron-Cloud-Induced Optics Distortions at CesrTA

    International Nuclear Information System (INIS)

    Crittenden, James; Penn, Gregory; Venturini, Marco; Harkay, Katherine; Holtzapple, Robert; Pivi, Mauro; Wang, Lanfa

    2012-01-01

    The Cornell Electron Storage Ring Test Accelerator (CesrTA) program has included extensive measurements of coherent betatron tune shifts for a variety of electron and positron beam energies, bunch population levels, and bunch train configurations. The tune shifts have been shown to result primarily from the interaction of the beam with the space-charge field of the beam-induced low-energy electron cloud in the vacuum chamber. Comparison to several advanced electron cloud simulation codes has allowed determination of the sensitivity of these measurements to physical parameters characterizing the synchrotron radiation flux, the production of photo-electrons on the vacuum chamber wall, the beam emittance, lattice optics, and the secondary-electron yield model. We report on progress in understanding the cloud buildup and decay mechanisms in magnetic fields and in field-free regions, addressing quantitatively the precise determination of the physical parameters of the modeling. Validation of these models will serve as essential input in the design of damping rings for future high-energy linear colliders.

  3. Progress in studies of Electron-Cloud-Induced Optics Distortions at CESRTA

    International Nuclear Information System (INIS)

    Crittenden, J.A.; Calvey, J.R.; Dugan, G.F.; Kreinick, D.L.; Leong, Z.; Livezey, J.A.; Palmer, M.A.; Rubin, D.L.; Sagan, D.C.; Holtzapple, R.L.; Furman, M.A.; Penn, G.; Venturini, M.; Pivi, M.; Wang, L.; Harkay, K.

    2010-01-01

    The Cornell Electron Storage Ring Test Accelerator (CesrTA) program has included extensive measurements of coherent betatron tune shifts for a variety of electron and positron beam energies, bunch population levels, and bunch train configurations. The tune shifts have been shown to result primarily from the interaction of the beam with the space-charge field of the beam-induced low energy electron cloud in the vacuum chamber. Comparison to several advanced electron cloud simulation program packages has allowed determination of the sensitivity of these measurements to physical parameters characterizing the synchrotron radiation flux, the production of photoelectrons on the vacuum chamberwall, the beam emittance, lattice optics, and the secondary-electron yield model. We report on progress in understanding the cloud buildup and decay mechanisms in magnetic fields and in field-free regions, addressing quantitatively the precise determination of the physical parameters of the modeling. Validation of these models will serve as essential input in the design of damping rings for future high-energy linear colliders.

  4. Interaction of plasma cloud with external electric field in lower ionosphere

    Directory of Open Access Journals (Sweden)

    Y. S. Dimant

    2010-03-01

    Full Text Available In the auroral lower-E and upper-D region of the ionosphere, plasma clouds, such as sporadic-E layers and meteor plasma trails, occur daily. Large-scale electric fields, created by the magnetospheric dynamo, will polarize these highly conducting clouds, redistributing the electrostatic potential and generating anisotropic currents both within and around the cloud. Using a simplified model of the cloud and the background ionosphere, we develop the first self-consistent three-dimensional analytical theory of these phenomena. For dense clouds, this theory predicts highly amplified electric fields around the cloud, along with strong currents collected from the ionosphere and circulated through the cloud. This has implications for the generation of plasma instabilities, electron heating, and global MHD modeling of magnetosphere-ionosphere coupling via modifications of conductances induced by sporadic-E clouds.

  5. Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype

    Directory of Open Access Journals (Sweden)

    Schillaci Tiziana

    2007-11-01

    Full Text Available Abstract Background Genetic instability is a hallmark of tumours and preneoplastic lesions. The predominant form of genome instability in human cancer is chromosome instability (CIN. CIN is characterized by chromosomal aberrations, gains or losses of whole chromosomes (aneuploidy, and it is often associated with centrosome amplification. Centrosomes control cell division by forming a bipolar mitotic spindle and play an essential role in the maintenance of chromosomal stability. However, whether centrosome amplification could directly cause aneuploidy is not fully established. Also, alterations in genes required for mitotic progression could be involved in CIN. A major candidate is represented by Aurora-A/STK15 that associates with centrosomes and is overexpressed in several types of human tumour. Methods Centrosome amplification were induced by hydroxyurea treatment and visualized by immunofluorescence microscopy. Aurora-A/STK15 ectopic expression was achieved by retroviral infection and puromycin selection in HCT116 tumour cells. Effects of Aurora-A/STK15 depletion on centrosome status and ploidy were determined by Aurora-A/STK15 transcriptional silencing by RNA interference. Changes in the expression levels of some mitotic genes were determined by Real time RT-PCR. Results We investigated whether amplification of centrosomes and overexpression of Aurora-A/STK15 induce CIN using as a model system a colon carcinoma cell line (HCT116. We found that in HCT116 cells, chromosomally stable and near diploid cells harbouring a MIN phenotype, centrosome amplification induced by hydroxyurea treatment is neither maintained nor induces aneuploidy. On the contrary, ectopic overexpression of Aurora-A/STK15 induced supernumerary centrosomes and aneuploidy. Aurora-A/STK15 transcriptional silencing by RNA interference in cells ectopically overexpressing this kinase promptly decreased cell numbers with supernumerary centrosomes and aneuploidy. Conclusion Our

  6. Observation of instability-induced current redistribution in a spherical-torus plasma.

    Science.gov (United States)

    Menard, J E; Bell, R E; Gates, D A; Kaye, S M; LeBlanc, B P; Levinton, F M; Medley, S S; Sabbagh, S A; Stutman, D; Tritz, K; Yuh, H

    2006-09-01

    A motional Stark effect diagnostic has been utilized to reconstruct the parallel current density profile in a spherical-torus plasma for the first time. The measured current profile compares favorably with neoclassical theory when no large-scale magnetohydrodynamic instabilities are present in the plasma. However, a current profile anomaly is observed during saturated interchange-type instability activity. This apparent anomaly can be explained by redistribution of neutral beam injection current drive and represents the first observation of interchange-type instabilities causing such redistribution. The associated current profile modifications contribute to sustaining the central safety factor above unity for over five resistive diffusion times, and similar processes may contribute to improved operational scenarios proposed for ITER.

  7. Electron-temperature-gradient-induced instability in tokamak scrape-off layers

    International Nuclear Information System (INIS)

    Berk, H.L.; Ryutov, D.D.; Tsidulko, Y.A.; Xu, X.Q.

    1992-08-01

    An electron temperature instability driven by the Kunkel-Guillory sheath impedance, has been applied to the scrape-off layer of tokamaks. The formalism has been generalized to more fully account for parallel wavelength dynamics, to differentiate between electromagnetic and electrostatic perturbations and to account for particle recycling effects. It is conjectured that this conducting wall instability leads to edge fluctuations in tokamaks that produce scrape-off widths of many ion Larmor radii ≅10. The predicted instability characteristics correlate somewhat with DIII-D edge fluctuation data, and the scrape-off layer width in the DIII-D experiment agrees with theoretical estimates that can be derived from mixing lenght theory

  8. Possible radioprotective effect of folic acid supplementation on low dose ionizing radiation-induced genomic instability in vitro.

    Science.gov (United States)

    Padula, Gisel; Ponzinibbio, María Virginia; Seoane, Analia I

    2016-08-01

    Ionizing radiation (IR) induces DNA damage through production of single and double-strand breaks and reactive oxygen species (ROS). Folic acid (FA) prevents radiation-induced DNA damage by modification of DNA synthesis and/or repair and as a radical scavenger. We hypothesized that in vitro supplementation with FA will decrease the sensitivity of cells to genetic damage induced by low dose of ionizing radiation. Annexin V, comet and micronucleus assays were performed in cultured CHO cells. After 7 days of pre-treatment with 0, 100, 200 or 300 nM FA, cultures were exposed to radiation (100 mSv). Two un-irradiated controls were executed (0 and 100 nM FA). Data were statistically analyzed with X2-test and linear regression analysis (P 0.05). We observed a significantly decreased frequency of apoptotic cells with the increasing FA concentration (P <0.05). The same trend was observed when analyzing DNA damage and chromosomal instability (P <0.05 for 300 nM). Only micronuclei frequencies showed significant differences for linear regression analysis (R2=94.04; P <0.01). Our results have demonstrated the radioprotective effect of folic acid supplementation on low dose ionizing radiation-induced genomic instability in vitro; folate status should be taken into account when studying the effect of low dose radiation in environmental or occupational exposure.

  9. Mechanical instability and titanium particles induce similar transcriptomic changes in a rat model for periprosthetic osteolysis and aseptic loosening

    Directory of Open Access Journals (Sweden)

    Mehdi Amirhosseini

    2017-12-01

    Full Text Available Wear debris particles released from prosthetic bearing surfaces and mechanical instability of implants are two main causes of periprosthetic osteolysis. While particle-induced loosening has been studied extensively, mechanisms through which mechanical factors lead to implant loosening have been less investigated. This study compares the transcriptional profiles associated with osteolysis in a rat model for aseptic loosening, induced by either mechanical instability or titanium particles. Rats were exposed to mechanical instability or titanium particles. After 15 min, 3, 48 or 120 h from start of the stimulation, gene expression changes in periprosthetic bone tissue was determined by microarray analysis. Microarray data were analyzed by PANTHER Gene List Analysis tool and Ingenuity Pathway Analysis (IPA. Both types of osteolytic stimulation led to gene regulation in comparison to unstimulated controls after 3, 48 or 120 h. However, when mechanical instability was compared to titanium particles, no gene showed a statistically significant difference (fold change ≥ ±1.5 and adjusted p-value ≤ 0.05 at any time point. There was a remarkable similarity in numbers and functional classification of regulated genes. Pathway analysis showed several inflammatory pathways activated by both stimuli, including Acute Phase Response signaling, IL-6 signaling and Oncostatin M signaling. Quantitative PCR confirmed the changes in expression of key genes involved in osteolysis observed by global transcriptomics. Inflammatory mediators including interleukin (IL-6, IL-1β, chemokine (C-C motif ligand (CCL2, prostaglandin-endoperoxide synthase (Ptgs2 and leukemia inhibitory factor (LIF showed strong upregulation, as assessed by both microarray and qPCR. By investigating genome-wide expression changes we show that, despite the different nature of mechanical implant instability and titanium particles, osteolysis seems to be induced through similar biological

  10. Ion cyclotron instability saturation and turbulent plasma heating in the presence of ions moving across the magnetic field

    International Nuclear Information System (INIS)

    Mikhajlenko, V.S.; Stepanov, K.N.

    1981-01-01

    Ion cyclotron instability saturation is considered in terms of the turbulence theory when there is a beam of heavy ions with large thermal longitudinal velocity spread. The instability excitation is due to a cyclotron interaction with ions of the beam under the anomalous Doppler effect. The instability is shown to be saturated due to an induced plasma ion scattering of ion cyclotron waves when the beam ion charge number Zsub(b) is approximately 1. Decay processes, wave scattering by virtual wave polarization clouds and resonance broadening due to random walk of plasma ions in turbulent instability fields appear to be unimportant. For Zsub(b)>>1 the induced wave scattering by the beam ions is the main process determining the nonlinear stage of the instability. Estimates are given for the oscillation energy density in the instability saturation state and for the turbulent heating rate of plasma and beam ions [ru

  11. Maternal effects of the scid mutation on radiation-induced transgenerational instability in mice.

    NARCIS (Netherlands)

    Hatch, T.; Derijck, A.H.A.; Black, P.D.; Heijden, G.W. van der; Boer, P. de; Dubrova, Y.E.

    2007-01-01

    The results of a number of recent studies show that mutation rates in the offspring of irradiated parents are substantially elevated, however, the effect of parental genotype on transgenerational instability remains poorly understood. Here, we have analysed the mutation frequency at an expanded

  12. Storm clouds on Saturn: Lightning-induced chemistry and associated materials consistent with Cassini/VIMS spectra

    Science.gov (United States)

    Baines, K.H.; Delitsky, M.L.; Momary, T.W.; Brown, R.H.; Buratti, B.J.; Clark, R.N.; Nicholson, P.D.

    2009-01-01

    Thunderstorm activity on Saturn is associated with optically detectable clouds that are atypically dark throughout the near-infrared. As observed by Cassini/VIMS, these clouds are ~20% less reflective than typical neighboring clouds throughout the spectral range from 0.8 ??m to at least 4.1 ??m. We propose that active thunderstorms originating in the 10-20 bar water-condensation region vertically transport dark materials at depth to the ~1 bar level where they can be observed. These materials in part may be produced by chemical processes associated with lightning, likely within the water clouds near the ~10 bar freezing level of water, as detected by the electrostatic discharge of lightning flashes observed by Cassini/RPWS (e.g., Fischer et al. 2008, Space Sci. Rev., 137, 271-285). We review lightning-induced pyrolytic chemistry involving a variety of Saturnian constituents, including hydrogen, methane, ammonia, hydrogen sulfide, phosphine, and water. We find that the lack of absorption in the 1-2 ??m spectral region by lightning-generated sulfuric and phosphorous condensates renders these constituents as minor players in determining the color of the dark storm clouds. Relatively small particulates of elemental carbon, formed by lightning-induced dissociation of methane and subsequently upwelled from depth - perhaps embedded within and on the surface of spectrally bright condensates such as ammonium hydrosulfide or ammonia - may be a dominant optical material within the dark thunderstorm-related clouds of Saturn. ?? 2009 Elsevier Ltd. All rights reserved.

  13. Double-strand break repair-adox: Restoration of suppressed double-strand break repair during mitosis induces genomic instability.

    Science.gov (United States)

    Terasawa, Masahiro; Shinohara, Akira; Shinohara, Miki

    2014-12-01

    Double-strand breaks (DSBs) are one of the severest types of DNA damage. Unrepaired DSBs easily induce cell death and chromosome aberrations. To maintain genomic stability, cells have checkpoint and DSB repair systems to respond to DNA damage throughout most of the cell cycle. The failure of this process often results in apoptosis or genomic instability, such as aneuploidy, deletion, or translocation. Therefore, DSB repair is essential for maintenance of genomic stability. During mitosis, however, cells seem to suppress the DNA damage response and proceed to the next G1 phase, even if there are unrepaired DSBs. The biological significance of this suppression is not known. In this review, we summarize recent studies of mitotic DSB repair and discuss the mechanisms of suppression of DSB repair during mitosis. DSB repair, which maintains genomic integrity in other phases of the cell cycle, is rather toxic to cells during mitosis, often resulting in chromosome missegregation and aberration. Cells have multiple safeguards to prevent genomic instability during mitosis: inhibition of 53BP1 or BRCA1 localization to DSB sites, which is important to promote non-homologous end joining or homologous recombination, respectively, and also modulation of the non-homologous end joining core complex to inhibit DSB repair. We discuss how DSBs during mitosis are toxic and the multiple safeguard systems that suppress genomic instability. © 2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

  14. Asymptotic behavior of the mixed mass in Rayleigh–Taylor and Richtmyer–Meshkov instability induced flows

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Ye; Cabot, William H. [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States); Thornber, Ben [The University of Sydney, School of Aerospace, Mechanical and Mechatronic Engineering, New South Wales 2006, Sydney (Australia)

    2016-05-15

    Rayleigh–Taylor instability (RTI) and Richtmyer–Meshkov instability (RMI) are serious practical issues in inertial confinement fusion research, and also have relevance to many cases of astrophysical fluid dynamics. So far, much of the attention has been paid to the late-time scaling of the mixed width, which is used as a surrogate to how well the fluids have been mixed. Yet, the actual amount of mixed mass could be viewed as a more direct indicator on the evolution of the mixing layers due to hydrodynamic instabilities. Despite its importance, there is no systematic study as yet on the scaling of the mixed mass for either the RTI or the RMI induced flow. In this article, the normalized mixed mass (Ψ) is introduced for measuring the efficiency of the mixed mass. Six large numerical simulation databases have been employed: the RTI cases with heavy-to-light fluid density ratios of 1.5, 3, and 9; the single shock RMI cases with density ratios of 3 and 20; and a reshock RMI case with density ratio of 3. Using simulated flow fields, the normalized mixed mass Ψ is shown to be more sensitive in discriminating the variation with Atwood number for the RTI flows. Moreover, Ψ is demonstrated to provide more consistent results for both the RTI and RMI flows when compared with the traditional mixedness parameters, Ξ and Θ.

  15. Stratified flow instability and slug formation leading to condensation-induced water hammer in a horizontal refrigerant pipe

    International Nuclear Information System (INIS)

    Samuel Martin, C.

    2005-01-01

    Full text of publication follows: An experimental apparatus was designed for the purpose of investigating the phenomenon of condensation-induced water hammer in an ammonia refrigeration system. Water hammer was initiated by introducing warm ammonia gas over static subcooled ammonia liquid placed in a horizontal 146.3 mm diameter carbon steel pipe 6.0 m in length. By means of fast response piezoelectric pressure transducers and a high speed data acquisition system rapid dynamic pressures were recorded whenever a shock event occurred. Moreover, by means of top-mounted diaphragm pressure transducers the speed of liquid slugs propagating along the pipe was determined. The occurrence of condensation induced water hammer depended upon three major variables; namely, (1) initial liquid depth, (2) liquid temperature, and (3) mass flow rate of warm gas. For given liquid depth and temperature, once the warm gas threshold conditions were exceeded shocks occurred with greater magnitude as the mass flow rate of gas input was increased. With adequate subcooling condensation-induced water hammer occurred for initial liquid depths ranging from 25% to 95% of internal pipe diameter. The threshold mass flow rate of warm gas necessary to initiate water hammer was greater as the initial liquid depth was lowered. Based upon experimental results obtained from four pressure transducers located on the top of the test pipe conditions corresponding to bridging were ascertained. For various initial liquid depths the onset of instability from stratified flow to bridging was correlated with the Taitel-Dukler instability criterion. (author)

  16. Using the thermal diffusion cloud chamber to study the ion-induced nucleation by radon decay

    International Nuclear Information System (INIS)

    Wu, Yefei.

    1991-01-01

    Thermal diffusion cloud chamber is steady-state device and has been extensively used for nucleation research. In order to study the ion-induced nucleation by radon decay, a new chamber was designed with improved both upper and bottom plates, the system of circulating fluid, the gasketting, the temperature measurement and the insulation. An alternative method of using oxygen as carrier gas was examined. Therefore, the heavy carrier gas including nitrogen, oxygen, neon, argon and air can be used to study radon radiolysis-induced nucleation for the water or organic compounds in the TDCC. The effects of the pressure and temperature ranges on the density, supersaturation, temperature and partial pressure profile for the water-oxygen-helium in the TDCC have been examined. Based on the classical theory, the rate profile of ion-induced nucleation by radon decays was calculated and compared with the homogeneous nucleation. From measured indoor concentrations of Volatile Organic Compounds (VOC), thermodynamic theory models were used to assess the possibility that these compounds will form ultrafine particles in indoor air by ion-induced nucleation. The energy, number of molecules and equilibrium radius of clusters have been calculated based on Such and Thomson theories. These two sets of values have been compared. Ion cluster radii corresponding to 1--3 VOC molecules are in range of 3--5 x 10 -8 cm. 43 refs., 18 figs., 5 tabs

  17. Joint Instability and Osteoarthritis

    Directory of Open Access Journals (Sweden)

    Darryl Blalock

    2015-01-01

    Full Text Available Joint instability creates a clinical and economic burden in the health care system. Injuries and disorders that directly damage the joint structure or lead to joint instability are highly associated with osteoarthritis (OA. Thus, understanding the physiology of joint stability and the mechanisms of joint instability-induced OA is of clinical significance. The first section of this review discusses the structure and function of major joint tissues, including periarticular muscles, which play a significant role in joint stability. Because the knee, ankle, and shoulder joints demonstrate a high incidence of ligament injury and joint instability, the second section summarizes the mechanisms of ligament injury-associated joint instability of these joints. The final section highlights the recent advances in the understanding of the mechanical and biological mechanisms of joint instability-induced OA. These advances may lead to new opportunities for clinical intervention in the prevention and early treatment of OA.

  18. Joint instability and osteoarthritis.

    Science.gov (United States)

    Blalock, Darryl; Miller, Andrew; Tilley, Michael; Wang, Jinxi

    2015-01-01

    Joint instability creates a clinical and economic burden in the health care system. Injuries and disorders that directly damage the joint structure or lead to joint instability are highly associated with osteoarthritis (OA). Thus, understanding the physiology of joint stability and the mechanisms of joint instability-induced OA is of clinical significance. The first section of this review discusses the structure and function of major joint tissues, including periarticular muscles, which play a significant role in joint stability. Because the knee, ankle, and shoulder joints demonstrate a high incidence of ligament injury and joint instability, the second section summarizes the mechanisms of ligament injury-associated joint instability of these joints. The final section highlights the recent advances in the understanding of the mechanical and biological mechanisms of joint instability-induced OA. These advances may lead to new opportunities for clinical intervention in the prevention and early treatment of OA.

  19. Pathogenesis of spinal cord involvement induced by lower cervical instability in rheumatoid spondylitis

    Energy Technology Data Exchange (ETDEWEB)

    Taniguchi, Hironobu; Kuwabara, Shigeru; Fukuda, Kenji; Kuroki, Tatsuji; Tajima, Naoya (Miyazaki Medical Coll., Kiyotake (Japan))

    1994-07-01

    To examine prognostic factors in rheumatoid arthritis (RA), plain radiography findings and magnetic resonance imaging (MRI) findings were compared with histopathological findings in 129 RA patients who had local or neurologic symptoms due to the cervical spine. All patients underwent plain radiography, and subdislocation more than 2 mm towards the anterior and posterior directions on plain radiographs was defined as instability. In predicting induction of instability of the inferior cervical spine and risk for spinal compression, erosion of the vertebral rim, as seen on plain X-rays, and irregular findings of the end-plate of the vertebral body and Gd-enhanced nodules around the intervertebral disk, as seen on MRI, seemed to be important. (N.K.).

  20. Numerical Simulations for the Beam-Induced Electron Cloud in the LHC Beam Screen

    CERN Document Server

    Brüning, Oliver Sim

    1998-01-01

    The following work summarises simulation results obtained at CERN for the beam-induced electron cloud and looks at possible cures for the heat load in the LHC beam screen. The synchrotron radiation in the LHC creates a continuous flow of photoelectrons. These electrons are accelerated by the electric field of the bunch and hit the vacuum chamber on the opposite side of the beam pipe where they crea te secondary electrons which are again accelerated by the next bunch. For a large secondary emission yield the above mechanism leads to an exponential growth of the electron cloud which is limited by space charge forces. The simulations use a two-dimensional mesh for the space charge calculations and include the effect of image charges on the vacuum chamber wall. Depending on the quantum yield for the production of photoelectrons, the secondary emission yield and the reflectivity, the heat load can vary from 0.1 W/m to more than 15 W/m.

  1. The role of free radicals and stress signalling in persistent genomic instability induced by long wavelength UV light

    International Nuclear Information System (INIS)

    Phillipson, R.; McMillan, T.J.

    2003-01-01

    Induction of persistent genomic instability has commonly been investigated with ionising radiation. It has been characterised as a decrease in plating efficiency, and an increase in chromosomal aberrations and mutation frequency in the progeny of cells that survive the initial irradiation. We now present data demonstrating the phenomenon following exposure to long-wavelength solar UV-A (320-400nm) radiation at environmentally relevant doses. Using the spontaneously immortalised human skin keratinocyte line, HaCaT, we observed a significant decrease in plating efficiency (77 +/- 2% of control), and increase in micronuclei (2.5 fold) and mutation frequency (2 fold), 7 days after the initial radiation insult. Modification of UV-A-induced instability by incubation with exogenous catalase implicated reactive oxygen species (ROS), in-particular hydrogen peroxide, in the production and/or maintenance of the phenomenon. Assessment of anti-oxidant enzymes revealed a significant increase in glutathione-s-transferase activity (158 +/- 4% of control) at day 7 in the irradiated cell population, which was inhibited by incubation with exogenous catalase (97 +/- 3%), providing further evidence for an ROS-mediated pathway. Furthermore, inhibition of UV-A-induced micronuclei at day 7 by the flavonoid-containing-protein inhibitor diphenyleneiodonium (DPI) indicates that the NADPH oxidase family of enzymes may be involved in this phenomenon. Measurement of superoxide production by the cytochrome c reduction assay revealed that the irradiated cell population produce 50% more superoxide than the unirradiated controls, and that incubation with DPI led to a preferential reduction in superoxide production in the UV-A treated population at day 7. Finally, NADPH oxidase activity is increased significantly over controls in UV-A-treated cells. These data demonstrate that oxidative stress, analogous to that produced by ionising radiation, induces persistent genomic instability through a

  2. Epigenetic dysregulation underlies radiation-induced transgenerational genome instability in vivo

    International Nuclear Information System (INIS)

    Koturbash, Igor; Baker, Mike; Loree, Jonathan; Kutanzi, Kristy; Hudson, Darryl; Pogribny, Igor; Sedelnikova, Olga; Bonner, William; Kovalchuk, Olga

    2006-01-01

    Purpose: Although modern cancer radiation therapy has led to increased patient survival rates, the risk of radiation treatment-related complications is becoming a growing problem. Among various complications, radiation also poses a threat to the progeny of exposed parents. It causes transgenerational genome instability that is linked to transgenerational carcinogenesis. Although the occurrence of transgenerational genome instability, which manifests as elevated delayed and nontargeted mutation, has been well documented, the mechanisms by which it arises remain obscure. We hypothesized that epigenetic alterations may play a pivotal role in the molecular etiology of transgenerational genome instability. Methods and Materials: We studied the levels of cytosine DNA methylation in somatic tissues of unexposed offspring upon maternal, paternal, or combined parental exposure. Results: We observed a significant loss of global cytosine DNA methylation in the thymus tissue of the offspring upon combined parental exposure. The loss of DNA methylation was paralleled by a significant decrease in the levels of maintenance (DNMT1) and de novo methyltransferases DNMT3a and 3b and methyl-CpG-binding protein MeCP2. Along with profound changes in DNA methylation, we noted a significant accumulation of DNA strand breaks in thymus, which is a radiation carcinogenesis target organ. Conclusions: The observed changes were indicative of a profound epigenetic dysregulation in the offspring, which in turn could lead to genome destabilization and possibly could serve as precursor for transgenerational carcinogenesis. Future studies are clearly needed to address the cellular and carcinogenic repercussions of those changes

  3. Applications of Analytical Self-Similar Solutions of Reynolds-Averaged Models for Instability-Induced Turbulent Mixing

    Science.gov (United States)

    Hartland, Tucker; Schilling, Oleg

    2017-11-01

    Analytical self-similar solutions to several families of single- and two-scale, eddy viscosity and Reynolds stress turbulence models are presented for Rayleigh-Taylor, Richtmyer-Meshkov, and Kelvin-Helmholtz instability-induced turbulent mixing. The use of algebraic relationships between model coefficients and physical observables (e.g., experimental growth rates) following from the self-similar solutions to calibrate a member of a given family of turbulence models is shown. It is demonstrated numerically that the algebraic relations accurately predict the value and variation of physical outputs of a Reynolds-averaged simulation in flow regimes that are consistent with the simplifying assumptions used to derive the solutions. The use of experimental and numerical simulation data on Reynolds stress anisotropy ratios to calibrate a Reynolds stress model is briefly illustrated. The implications of the analytical solutions for future Reynolds-averaged modeling of hydrodynamic instability-induced mixing are briefly discussed. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  4. Field-induced magnetic instability and quantum criticality in the antiferromagnet CeCu2Ge2.

    Science.gov (United States)

    Liu, Yi; Xie, Donghua; Wang, Xiaoying; Zhu, Kangwei; Yang, Ruilong

    2016-01-13

    The magnetic quantum criticality in strongly correlated electron systems has been considered to be closely related with the occurrence of unconventional superconductivity. Control parameters such as magnetic field, pressure or chemical doping are frequently used to externally tune the quantum phase transition for a deeper understanding. Here we report the research of a field-induced quantum phase transition using conventional bulk physical property measurements in the archetypal antiferromagnet CeCu2Ge2, which becomes superconductive under a pressure of about 10 GPa with Tc ~ 0.64 K. We offer strong evidence that short-range dynamic correlations start appearing above a magnetic field of about 5 T. Our demonstrations of the magnetic instability and the field-induced quantum phase transition are crucial for the quantum criticality, which may open a new route in experimental investigations of the quantum phase transition in heavy-fermion systems.

  5. Analysis of rainfall-induced slope instability using a field of local factor of safety

    Science.gov (United States)

    Lu, Ning; Şener-Kaya, Başak; Wayllace, Alexandra; Godt, Jonathan W.

    2012-01-01

    Slope-stability analyses are mostly conducted by identifying or assuming a potential failure surface and assessing the factor of safety (FS) of that surface. This approach of assigning a single FS to a potentially unstable slope provides little insight on where the failure initiates or the ultimate geometry and location of a landslide rupture surface. We describe a method to quantify a scalar field of FS based on the concept of the Coulomb stress and the shift in the state of stress toward failure that results from rainfall infiltration. The FS at each point within a hillslope is called the local factor of safety (LFS) and is defined as the ratio of the Coulomb stress at the current state of stress to the Coulomb stress of the potential failure state under the Mohr-Coulomb criterion. Comparative assessment with limit-equilibrium and hybrid finite element limit-equilibrium methods show that the proposed LFS is consistent with these approaches and yields additional insight into the geometry and location of the potential failure surface and how instability may initiate and evolve with changes in pore water conditions. Quantitative assessments applying the new LFS field method to slopes under infiltration conditions demonstrate that the LFS has the potential to overcome several major limitations in the classical FS methodologies such as the shape of the failure surface and the inherent underestimation of slope instability. Comparison with infinite-slope methods, including a recent extension to variably saturated conditions, shows further enhancement in assessing shallow landslide occurrence using the LFS methodology. Although we use only a linear elastic solution for the state of stress with no post-failure analysis that require more sophisticated elastoplastic or other theories, the LFS provides a new means to quantify the potential instability zones in hillslopes under variably saturated conditions using stress-field based methods.

  6. Excitation of an instability by neutral particle ionization induced fluxes in the tokamak edge plasma

    International Nuclear Information System (INIS)

    Bachmann, P.; Sunder, D.

    1991-01-01

    Strong density and potential fluctuations in the edge plasma of toroidal nuclear fusion devices can lead to anomalously fast particle and energy transport. There are some reasons to assume the level of these fluctuations to be connected with neutral particles which enter the plasma by gas puffing or recycling processes. The influence of neutral particles on the behaviour of electrostatic drift modes was investigated. Using the ballooning transformation the excitation of dissipative drift waves in tokamak was studied taking ionization and charge exchange into consideration. Ionization driven drift wave turbulence was analyzed. The higher the neutral particle density is the more important the plasma-wall interaction and the less important the action of the limiter becomes. Instabilities localized in the edge plasma and far from the limiter can be one of the reasons of such a phenomenon. In the present paper we show that such an instability may exist. Usually the neutral particle density is large in the vicinity of the limiter and decreases rapidly with the distance from it. Plasma particles generated by ionization of these neutrals outside the limiter shadow, move along the magnetic field lines into a region without neutrals and diffuse slowly across the magnetic field. We solve the stability problem for modes with a perpendicular wave length that is much larger than the ion Larmor radius with electron temperature, and much smaller than the minor plasma radius. The excitation of such modes localized far from the limiter is investigated. A one-dimensional differential equation is derived in the cold ion approximation without taking shear and toroidal effects into consideration. In the case of low flow velocities a nearly aperiodic instability is found analytically. Its growth rate is proportional to the equilibrium plasma velocity at the boundary of the neutral particle's free region and to the inverse of the extension of this zone. This mode is localized in the edge

  7. New macroscopic theory of anamalous diffusion induced by the dissipative trapped-ion instability

    International Nuclear Information System (INIS)

    Wimmel, H.K.

    1975-03-01

    For an axisymmetric toroidal plasma of the TOKAMAK type a new set of dissipative trapped-fluid equations is established. In addition to E vector x B vector drifts and collisions of the trapped particles, these equations take full account of the effect of Esub(//) (of the trapped ion modes) on free and trapped particles, and of the effect of grad delta 0 (delta 0 = equilibrium fraction of trapped particles). From the new equations the linear-mode properties of the dissipative trapped-ion instability and the anomalous diffusion flux of the trapped particles are derived. (orig.) [de

  8. Self-induced dipole force and filamentation instability of a matter wave

    DEFF Research Database (Denmark)

    Saffman, M.

    1998-01-01

    The interaction of copropagating electromagnetic and matter waves is described with a set of coupled higher-order nonlinear Schrodinger equations. Optical self-focusing modulates an initially planar wave leading to the generation of dipole forces on the atoms. Atomic channeling due to the dipole...... forces leads, in the nonlinear regime, to filamentation of the atomic beam. Instability growth rates are calculated for atomic beams with both low and high phase space densities. In one transverse dimension an exact solution is found that describes a coupled optical and atomic soliton....

  9. Investigation on the negative bias illumination stress-induced instability of amorphous indium-tin-zinc-oxide thin film transistors

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Jaeman; Kim, Dae Geun; Kim, Dong Myong; Choi, Sung-Jin; Kim, Dae Hwan, E-mail: byungdu.ahn@samsung.com, E-mail: drlife@kookmin.ac.kr [School of Electrical Engineering, Kookmin University, Seoul 136-702 (Korea, Republic of); Lim, Jun-Hyung; Lee, Je-Hun; Ahn, Byung Du, E-mail: byungdu.ahn@samsung.com, E-mail: drlife@kookmin.ac.kr [Samsung Display Co., Ltd., Yongin, Gyeonggi-Do 446-711 (Korea, Republic of); Kim, Yong-Sung [Korea Research Institute of Standards and Science, Yuseong, Daejeon 305-340 (Korea, Republic of)

    2014-10-13

    The quantitative analysis of mechanism on negative bias illumination stress (NBIS)-induced instability of amorphous indium-tin-zinc-oxide thin-film transistor (TFT) was suggested along with the effect of equivalent oxide thickness (EOT) of gate insulator. The analysis was implemented through combining the experimentally extracted density of subgap states and the device simulation. During NBIS, it was observed that the thicker EOT causes increase in both the shift of threshold voltage and the variation of subthreshold swing as well as the hump-like feature in a transfer curve. We found that the EOT-dependence of NBIS instability can be clearly explicated with the donor creation model, in which a larger amount of valence band tail states is transformed into either the ionized oxygen vacancy V{sub O}{sup 2+} or peroxide O{sub 2}{sup 2−} with the increase of EOT. It was also found that the V{sub O}{sup 2+}-related extrinsic factor accounts for 80%–92% of the total donor creation taking place in the valence band tail states while the rest is taken by the O{sub 2}{sup 2–} related intrinsic factor. The ratio of extrinsic factor compared to the total donor creation also increased with the increase of EOT, which could be explained by more prominent oxygen deficiency. The key founding of our work certainly represents that the established model should be considered very effective for analyzing the instability of the post-indium-gallium-zinc-oxide (IGZO) ZnO-based compound semiconductor TFTs with the mobility, which is much higher than those of a-IGZO TFTs.

  10. Dynamical instability induced by the zero mode under symmetry breaking external perturbation

    International Nuclear Information System (INIS)

    Takahashi, J.; Nakamura, Y.; Yamanaka, Y.

    2014-01-01

    A complex eigenvalue in the Bogoliubov–de Gennes equations for a stationary Bose-Einstein condensate in the ultracold atomic system indicates the dynamical instability of the system. We also have the modes with zero eigenvalues for the condensate, called the zero modes, which originate from the spontaneous breakdown of symmetries. Although the zero modes are suppressed in many theoretical analyses, we take account of them in this paper and argue that a zero mode can change into one with a pure imaginary eigenvalue by applying a symmetry breaking external perturbation potential. This emergence of a pure imaginary mode adds a new type of scenario of dynamical instability to that characterized by the complex eigenvalue of the usual excitation modes. For illustration, we deal with two one-dimensional homogeneous Bose–Einstein condensate systems with a single dark soliton under a respective perturbation potential, breaking the invariance under translation, to derive pure imaginary modes. - Highlights: • Zero modes are important but ignored in many theories for the cold atomic system. • We discuss the zero mode under symmetry breaking potential in this system. • We consider the zero mode of translational invariance for a single dark soliton. • We show that it turns into an anomalous or pure imaginary mode

  11. Surface-Energy-Anisotropy-Induced Orientation Effects on RayleighInstabilities in Sapphire

    Energy Technology Data Exchange (ETDEWEB)

    Santala, Melissa; Glaeser, Andreas M.

    2006-01-01

    Arrays of controlled-geometry, semi-infinite pore channels of systematically varied crystallographic orientation were introduced into undoped m-plane (10{bar 1}0) sapphire substrates using microfabrication techniques and ion-beam etching and subsequently internalized by solid-state diffusion bonding. A series of anneals at 1700 C caused the breakup of these channels into discrete pores via Rayleigh instabilities. In all cases, channels broke up with a characteristic wavelength larger than that expected for a material with isotropic surface energy, reflecting stabilization effects due to surface-energy anisotropy. The breakup wavelength and the time required for complete breakup varied significantly with channel orientation. For most orientations, the instability wavelength for channels of radius R was in the range of 13.2R-25R, and complete breakup occurred within 2-10 h. To first order, the anneal times for complete breakup scale with the square of the breakup wavelength. Channels oriented along a <11{bar 2}0> direction had a wavelength of {approx} 139R, and required 468 h for complete breakup. Cross-sectional analysis of channels oriented along a <11{bar 2}0> direction showed the channel to be completely bounded by stable c(0001), r{l_brace}{bar 1}012{r_brace}, and s{l_brace}10{bar 1}1{r_brace} facets.

  12. Parametric instability producing broad symmetrical structure in the spectrum of ionospheric heating-induced radiation

    International Nuclear Information System (INIS)

    Kuo, S.P.

    1997-01-01

    A four-wave interaction process in which an O-mode electromagnetic pump decays parametrically into a lower hybrid decay mode and two-electron Bernstein sidebands is analyzed. It is shown that the instability can be excited in a spatial region near the electron Bernstein/upper hybrid double resonance and in a narrow pump frequency range slightly below the third harmonic electron cyclotron resonance. The two electron Bernstein sidebands have about the same intensity and thus, produce Broad Symmetrical Structure (BSS) in the emission spectrum after being converted into electromagnetic radiation by scattering off background field-aligned density irregularities. The results also show that the size of the instability zone becomes very small as the pump frequency operates near a cyclotron harmonic higher than the third. Thus, the converted emission will be too weak to be detected. This explains why the BSS feature in the spectrum of stimulated electromagnetic emissions (SEEs) has only been observed in the third harmonic case. copyright 1997 American Institute of Physics

  13. The CLOUD experiment

    CERN Multimedia

    Maximilien Brice

    2006-01-01

    The Cosmics Leaving Outdoor Droplets (CLOUD) experiment as shown by Jasper Kirkby (spokesperson). Kirkby shows a sketch to illustrate the possible link between galactic cosmic rays and cloud formations. The CLOUD experiment uses beams from the PS accelerator at CERN to simulate the effect of cosmic rays on cloud formations in the Earth's atmosphere. It is thought that cosmic ray intensity is linked to the amount of low cloud cover due to the formation of aerosols, which induce condensation.

  14. Causality between expansion of seismic cloud and maximum magnitude of induced seismicity in geothermal field

    Science.gov (United States)

    Mukuhira, Yusuke; Asanuma, Hiroshi; Ito, Takatoshi; Häring, Markus

    2016-04-01

    Occurrence of induced seismicity with large magnitude is critical environmental issues associated with fluid injection for shale gas/oil extraction, waste water disposal, carbon capture and storage, and engineered geothermal systems (EGS). Studies for prediction of the hazardous seismicity and risk assessment of induced seismicity has been activated recently. Many of these studies are based on the seismological statistics and these models use the information of the occurrence time and event magnitude. We have originally developed physics based model named "possible seismic moment model" to evaluate seismic activity and assess seismic moment which can be ready to release. This model is totally based on microseismic information of occurrence time, hypocenter location and magnitude (seismic moment). This model assumes existence of representative parameter having physical meaning that release-able seismic moment per rock volume (seismic moment density) at given field. Seismic moment density is to be estimated from microseismic distribution and their seismic moment. In addition to this, stimulated rock volume is also inferred by progress of microseismic cloud at given time and this quantity can be interpreted as the rock volume which can release seismic energy due to weakening effect of normal stress by injected fluid. Product of these two parameters (equation (1)) provide possible seismic moment which can be released from current stimulated zone as a model output. Difference between output of this model and observed cumulative seismic moment corresponds the seismic moment which will be released in future, based on current stimulation conditions. This value can be translated into possible maximum magnitude of induced seismicity in future. As this way, possible seismic moment can be used to have feedback to hydraulic stimulation operation in real time as an index which can be interpreted easily and intuitively. Possible seismic moment is defined as equation (1), where D

  15. In Situ Measurement of Seeking Speed and Seeking Induced Head-Disk Interface Instability in Hard Disk Drives

    Directory of Open Access Journals (Sweden)

    Yu Wang

    2015-01-01

    Full Text Available This paper investigated the instability of head-disk interface caused by the voice coil motor (VCM end crashing the crash stop during the seeking of magnetic head. To make the whole process of that clear, an in situ measurement method based on maximum likelihood estimation and extended Kalman filter for seeking speed at component level was developed first and was then calibrated by a high speed camera. Given a crash between VCM end and crash stop that may be a consequence of the continuous increasing seeking speed, the seeking speed was carefully controlled by using our developed method to find a critical value that may induce vigorous head-disk interface instability. Acoustic emission sensor and laser Doppler vibrometer were used to capture the transient dynamic behaviors of magnetic head when the crash is happening. Damage analysis and mode identification were carried out to reveal the relationship between the damage patterns on disk surface and head dynamics. The results of this study are helpful to optimize the track seeking profile during the HDD operation, as well as the design of components such as head and head arm.

  16. Non-homologous end-joining genes are not inactivated in human radiation-induced sarcomas with genomic instability

    International Nuclear Information System (INIS)

    Lefevre, S.H.; Coquelle, A.; Gonin-Laurent, N.

    2005-01-01

    DNA double-strand break (DSB) repair pathways are implicated in the maintenance of genomic stability. However the alterations of these pathways, as may occur in human tumor cells with strong genomic instability, remain poorly characterized. We analyzed the loss of heterozygosity (LOH) and the presence of mutations for a series of genes implicated in DSB repair by non-homologous end-joining in five radiation-induced sarcomas devoid of both active Tp53 and Rb1. LOH was recurrently observed for 8 of the 9 studied genes (KU70, KU80, XRCC4, LIG4, Artemis, MRE11, RAD50, NBS1) but not for DNA-PKcs. No mutation was found in the remaining allele of the genes with LOH and the mRNA expression did not correlate with the allelic status. Our findings suggest that non-homologous end-joining repair pathway alteration is unlikely to be involved in the high genomic instability observed in these tumors. (author)

  17. Genomic instability following irradiation

    International Nuclear Information System (INIS)

    Hacker-Klom, U.B.; Goehde, W.

    2001-01-01

    Ionising irradiation may induce genomic instability. The broad spectrum of stress reactions in eukaryontic cells to irradiation complicates the discovery of cellular targets and pathways inducing genomic instability. Irradiation may initiate genomic instability by deletion of genes controlling stability, by induction of genes stimulating instability and/or by activating endogeneous cellular viruses. Alternatively or additionally it is discussed that the initiation of genomic instability may be a consequence of radiation or other agents independently of DNA damage implying non nuclear targets, e.g. signal cascades. As a further mechanism possibly involved our own results may suggest radiation-induced changes in chromatin structure. Once initiated the process of genomic instability probably is perpetuated by endogeneous processes necessary for proliferation. Genomic instability may be a cause or a consequence of the neoplastic phenotype. As a conclusion from the data available up to now a new interpretation of low level radiation effects for radiation protection and in radiotherapy appears useful. The detection of the molecular mechanisms of genomic instability will be important in this context and may contribute to a better understanding of phenomenons occurring at low doses <10 cSv which are not well understood up to now. (orig.)

  18. Vector condensate and AdS soliton instability induced by a magnetic field

    International Nuclear Information System (INIS)

    Cai, Rong-Gen; Li, Li; Li, Li-Fang; Wu, You

    2014-01-01

    We continue to study the holographic p-wave superconductor model in the Einstein-Maxwell-complex vector field theory with a non-minimal coupling between the complex vector field and the Maxwell field. In this paper we work in the AdS soliton background which describes a conformal field theory in the confined phase and focus on the probe approximation. We find that an applied magnetic field can lead to the condensate of the vector field and the AdS soliton instability. As a result, a vortex lattice structure forms in the spatial directions perpendicular to the applied magnetic field. As a comparison, we also discuss the vector condensate in the Einstein-SU(2) Yang-Mills theory and find that in the setup of the present paper, the Einstein-Maxwell-complex vector field model is a generalization of the SU(2) model in the sense that the vector field has a general mass and gyromagnetic ratio

  19. Laser-induced hydrodynamic instability and pattern formation in metallic nanofilms

    Science.gov (United States)

    Sureshkumar, R.; Trice, J.; Favazza, C.; Kalyanaraman, R.

    2007-11-01

    Cost effective methodologies for the robust generation of nanoscale patterns in thin films and at interfaces are crucial in photonic, opto-electronic and solar energy harvesting applications. When ultrathin metal films are exposed to a series of short (ns) laser pulses, spontaneous pattern formation results with spatio-temporal scales that depend on the film height and thermo-physical properties of the film/substrate bilayer. Various self-organization mechanisms have been identified, including a dewetting instability due to a competition between surface tension and dispersion forces, and intrinsic and/or extrinsic thermocapillary effects. We will discuss these mechanisms as well as the evolution of surface perturbations which have been explored using experiments, linear stability analysis and nonlinear dynamical simulations (Trice et al. Phys. Rev. B, 75, 235439 (2007); Favazza et al. Appl. Phys. Lett., 91, 043105 (2007); 88, 153118 (2006)).

  20. Thermal Instability Induced Oriented 2D Pores for Enhanced Sodium Storage.

    Science.gov (United States)

    Kong, Lingjun; Xie, Chen-Chao; Gu, Haichen; Wang, Chao-Peng; Zhou, Xianlong; Liu, Jian; Zhou, Zhen; Li, Zhao-Yang; Zhu, Jian; Bu, Xian-He

    2018-04-19

    Hierarchical porous structures are highly desired for various applications. However, it is still challenging to obtain such materials with tunable architectures. Here, this paper reports hierarchical nanomaterials with oriented 2D pores by taking advantages of thermally instable bonds in vanadium-based metal-organic frameworks (MOFs). High-temperature calcination of these MOFs accompanied by the loss of coordinated water molecules and other components enables the formation of orderly slit-like 2D pores in vanadium oxide/porous carbon nanorods (VO x /PCs). This unique combination leads to an increase of the reactive surface area. In addition, optimized VO x /PCs demonstrate high-rate capability and ultralong cycling life for sodium storage. The assembled full cells also show high capacity and cycling stability. This report provides an effective strategy for producing MOFs-derived composites with hierarchical porous architectures for energy storage. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Lidar observation and model simulation of a volcanic-ash-induced cirrus cloud during the Eyjafjallajökull eruption

    Directory of Open Access Journals (Sweden)

    C. Rolf

    2012-11-01

    Full Text Available Heterogeneous ice formation induced by volcanic ash from the Eyjafjallajökull volcano eruption in April 2010 is investigated based on the combination of a cirrus cloud observed with a backscatter lidar over Jülich (western Germany and model simulations along backward trajectories. The microphysical properties of the cirrus cloud could only be represented by the microphysical model under the assumption of an enhanced number of efficient ice nuclei originating from the volcanic eruption. The ice nuclei (IN concentration determined by lidar measurements directly before and after cirrus cloud occurrence implies a value of around 0.1 cm−3 (in comparison normal IN conditions: 0.01 cm−3. This leads to a cirrus cloud with rather small ice crystals having a mean radius of 12 μm and a modification of the ice particle number (0.08 cm−3 instead of 3 × 10−4 cm−3 under normal IN conditions. The effectiveness of ice nuclei was estimated by the use of the microphysical model and the backward trajectories based on ECMWF data, establishing a freezing threshold of around 105% relative humidity with respect to ice in a temperature range from −45 to −55 °C . Only with these highly efficient ice nuclei was it possible for the cirrus cloud to be formed in a slightly supersaturated environment.

  2. Suppression of photo-bias induced instability for amorphous indium tungsten oxide thin film transistors with bi-layer structure

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Po-Tsun, E-mail: ptliu@mail.nctu.edu.tw; Chang, Chih-Hsiang; Chang, Chih-Jui [Department of Photonics and Institute of Electro-Optical Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan (China)

    2016-06-27

    This study investigates the instability induced by bias temperature illumination stress (NBTIS) for an amorphous indium-tungsten-oxide thin film transistor (a-IWO TFT) with SiO{sub 2} backchannel passivation layer (BPL). It is found that this electrical degradation phenomenon can be attributed to the generation of defect states during the BPL process, which deteriorates the photo-bias stability of a-IWO TFTs. A method proposed by adding an oxygen-rich a-IWO thin film upon the a-IWO active channel layer could effectively suppress the plasma damage to channel layer during BPL deposition process. The bi-layer a-IWO TFT structure with an oxygen-rich back channel exhibits superior electrical reliability of device under NBTIS.

  3. Buneman instability and Pierce instability in a collisionless bounded plasma

    International Nuclear Information System (INIS)

    Iizuka, Satoru; Saeki, Koichi; Sato, Noriyoshi; Hatta, Yoshisuke

    1983-01-01

    A systematic experiment is performed on the Buneman instability and the Pierce instability in a bounded plasma consisting of beam electrons and stationary ions. Current fluctuations are confirmed to be induced by the Buneman instability. On the other hand, the Pierce instability gives rise to a current limitation. The phenomena are well explained by Mikhailovskii's theory taking account of ion motion in a bounded plasma. (author)

  4. Quantitative analysis of negative bias illumination stress-induced instability mechanisms in amorphous InGaZnO thin-film transistors

    International Nuclear Information System (INIS)

    Kim, Yong Sik; Bae, Min Kyung; Kong, Dong Sik; Jung, Hyun Kwang; Kim, Jae Hyeong; Kim, Woo Joon; Hur, In Seok; Kim, Dong Myong; Kim, Dae Hwan

    2011-01-01

    The physical origins of the negative bias illumination stress (NBIS)-induced threshold voltage shift (ΔV T ) in amorphous InGaZnO (a-IGZO) thin-film transistors (TFTs) under ambient light from a backlight unit are quantitatively and systematically investigated. Furthermore, a methodology for extracting the instability parameters is proposed and demonstrated. For the quantitative analysis, the subgap density-of-states (DOS)-based DC I-V model is intensively used. The NBIS time-evolution of the measured I DS -V GS characteristics is reproduced very well via the proposed methodology and instability parameters. Consequently, photo-excited electron detrapping, followed by ionization of oxygen vacancies (V O +2 ) and field-enhanced V O +2 diffusion, followed by hole trapping into the gate insulator, are found to be the dominant mechanisms in NBIS-induced instability of a-IGZO TFTs.

  5. Electron Cloud Effect in the Linear Colliders

    International Nuclear Information System (INIS)

    Pivi, M

    2004-01-01

    Beam induced multipacting, driven by the electric field of successive positively charged bunches, may arise from a resonant motion of electrons, generated by secondary emission, bouncing back and forth between opposite walls of the vacuum chamber. The electron-cloud effect (ECE) has been observed or is expected at many storage rings [1]. In the beam pipe of the Damping Ring (DR) of a linear collider, an electron cloud is produced initially by ionization of the residual gas and photoelectrons from the synchrotron radiation. The cloud is then sustained by secondary electron emission. This electron cloud can reach equilibrium after the passage of only a few bunches. The electron-cloud effect may be responsible for collective effects as fast coupled-bunch and single-bunch instability, emittance blow-up or incoherent tune shift when the bunch current exceeds a certain threshold, accompanied by a large number of electrons in the vacuum chamber. The ECE was identified as one of the most important R and D topics in the International Linear Collider Report [2]. Systematic studies on the possible electron-cloud effect have been initiated at SLAC for the GLC/NLC and TESLA linear colliders, with particular attention to the effect in the positron main damping ring (MDR) and the positron Low Emittance Transport which includes the bunch compressor system (BCS), the main linac, and the beam delivery system (BDS). We present recent computer simulation results for the main features of the electron cloud generation in both machine designs. Thus, single and coupled-bunch instability thresholds are estimated for the GLC/NLC design

  6. ISM-induced erosion and gas-dynamical drag in the Oort Cloud

    International Nuclear Information System (INIS)

    Stern, S.A.

    1990-01-01

    The model presently used to examine the physical interactions between the ISM and the Oort Cloud can account for sputtering, sticking, and grain-impact erosion, as well as gas drag, by envisioning the ISM as a multiphase medium with distinct atomic and molecular cloud-phase regimes and coronal and warm/ambient gas-phase regimes. Erosion, which reduces the effectiveness of the thermal and radiation-damage processes acting on cometary surfaces in the Oort cloud, is found to be the dominant ISM interaction; ISM drag effects were found to efficiently remove submicron particles from the Cloud. 67 refs

  7. ISM-induced erosion and gas-dynamical drag in the Oort Cloud

    Science.gov (United States)

    Stern, S. Alan

    1990-01-01

    The model presently used to examine the physical interactions between the ISM and the Oort Cloud can account for sputtering, sticking, and grain-impact erosion, as well as gas drag, by envisioning the ISM as a multiphase medium with distinct atomic and molecular cloud-phase regimes and coronal and warm/ambient gas-phase regimes. Erosion, which reduces the effectiveness of the thermal and radiation-damage processes acting on cometary surfaces in the Oort cloud, is found to be the dominant ISM interaction; ISM drag effects were found to efficiently remove submicron particles from the Cloud.

  8. Delayed cell death, giant cell formation and chromosome instability induced by X-irradiation in human embryo cells

    International Nuclear Information System (INIS)

    Roy, K.; Kodama, Seiji; Suzuki, Keiji; Watanabe, Masami

    1999-01-01

    We studied X-ray-induced delayed cell death, delayed giant cell formation and delayed chromosome aberrations in normal human embryo cells to explore the relationship between initial radiation damage and delayed effect appeared at 14 to 55 population doubling numbers (PDNs) after X-irradiation. The delayed effect was induced in the progeny of X-ray survivors in a dose-dependent manner and recovered with increasing PDNs after X-irradiation. Delayed plating for 24 h post-irradiation reduced both acute and delayed lethal damage, suggesting that potentially lethal damage repair (PLDR) can be effective for relieving the delayed cell death. The chromosome analysis revealed that most of the dicentrics (more than 90%) observed in the progeny of X-ray survivors were not accompanied with fragments, in contrast with those observed in the first mitosis after X-irradiation. The present results indicate that the potentiality of genetic instability is determined during the repair process of initial radiation damage and suggest that the mechanism for formation of delayed chromosome aberrations by radiation might be different from that of direct radiation-induced chromosome aberrations. (author)

  9. Electron cloud observations: a retrospective

    International Nuclear Information System (INIS)

    Harkay, K.

    2004-01-01

    A growing number of observations of electron cloud effects (ECEs) have been reported in positron and proton rings. Low-energy, background electrons ubiquitous in high-intensity particle accelerators. Amplification of electron cloud (EC) can occur under certain operating conditions, potentially giving rise to numerous effects that can seriously degrade accelerator performance. EC observations and diagnostics have contributed to a better understanding of ECEs, in particular, details of beam-induced multipacting and cloud saturation effects. Such experimental results can be used to provide realistic limits on key input parameters for modeling efforts and analytical calculations to improve prediction capability. Electron cloud effects are increasingly important phenomena in high luminosity, high brightness, or high intensity machines - Colliders, Storage rings, Damping rings, Heavy ion beams. EC generation and instability modeling increasingly complex and benchmarked against in situ data: (delta), (delta) 0 , photon reflectivity, and SE energy distributions important. Surface conditioning and use of solenoidal windings in field-free regions are successful cures: will they be enough? What are new observations and how do they contribute to body of work and understanding physics of EC?

  10. Static and Dynamic Water Motion-Induced Instability in Oxide Thin-Film Transistors and Its Suppression by Using Low-k Fluoropolymer Passivation.

    Science.gov (United States)

    Choi, Seungbeom; Jo, Jeong-Wan; Kim, Jaeyoung; Song, Seungho; Kim, Jaekyun; Park, Sung Kyu; Kim, Yong-Hoon

    2017-08-09

    Here, we report static and dynamic water motion-induced instability in indium-gallium-zinc-oxide (IGZO) thin-film transistors (TFTs) and its effective suppression with the use of a simple, solution-processed low-k (ε ∼ 1.9) fluoroplastic resin (FPR) passivation layer. The liquid-contact electrification effect, in which an undesirable drain current modulation is induced by a dynamic motion of a charged liquid such as water, can cause a significant instability in IGZO TFTs. It was found that by adopting a thin (∼44 nm) FPR passivation layer for IGZO TFTs, the current modulation induced by the water-contact electrification was greatly reduced in both off- and on-states of the device. In addition, the FPR-passivated IGZO TFTs exhibited an excellent stability to static water exposure (a threshold voltage shift of +0.8 V upon 3600 s of water soaking), which is attributed to the hydrophobicity of the FPR passivation layer. Here, we discuss the origin of the current instability caused by the liquid-contact electrification as well as various static and dynamic stability tests for IGZO TFTs. On the basis of our findings, we believe that the use of a thin, solution-processed FPR passivation layer is effective in suppressing the static and dynamic water motion-induced instabilities, which may enable the realization of high-performance and environment-stable oxide TFTs for emerging wearable and skin-like electronics.

  11. Scenarios for the nonlinear evolution of alpha particle induced Alfven wave instability

    International Nuclear Information System (INIS)

    Berk, H.L.; Breizman, B.N.; Ye, Huanchun.

    1992-03-01

    Various nonlinear scenarios are given for the evolution of energetic particles that are slowing down in a background plasma and simultaneously causing instability of the background plasma waves. If the background damping is sufficiently weak, a steady-state wave is established as described by Berk and Breizman. For larger background damping rate pulsations develop. Saturation occurs when the wave amplitude rises to where the wave trapping frequency equals the growth rate. The wave then damps due to the small background dissipation present and a relatively long quiet interval exists between bursts while the free energy of the distribution is refilled by classical transport. In this scenario the anomalous energy loss of energetic particles due to diffusion is small compared to the classical collisional energy exchange with the background plasma. However, if at the trapping frequency, the wave amplitude is large enough to cause orbit stochasticity, a phase space ''explosion'' occurs where the wave amplitudes rise to higher levels which leads to rapid loss of energetic particles

  12. Relationships Between Tropical Deep Convection, Tropospheric Mean Temperature and Cloud-Induced Radiative Fluxes on Intraseasonal Time Scales

    Science.gov (United States)

    Ramey, Holly S.; Robertson, Franklin R.

    2010-01-01

    Intraseasonal variability of deep convection represents a fundamental mode of variability in the organization of tropical convection. While most studies of intraseasonal oscillations (ISOs) have focused on the spatial propagation and dynamics of convectively coupled circulations, we examine the projection of ISOs on the tropically-averaged temperature and energy budget. The area of interest is the global oceans between 20degN/S. Our analysis then focuses on these questions: (i) How is tropospheric temperature related to tropical deep convection and the associated ice cloud fractional amount (ICF) and ice water path (IWP)? (ii) What is the source of moisture sustaining the convection and what role does deep convection play in mediating the PBL - free atmospheric temperature equilibration? (iii) What affect do convectively generated upper-tropospheric clouds have on the TOA radiation budget? Our methodology is similar to that of Spencer et al., (2007) with some modifications and some additional diagnostics of both clouds and boundary layer thermodynamics. A composite ISO time series of cloud, precipitation and radiation quantities built from nearly 40 events during a six-year period is referenced to the atmospheric temperature signal. The increase of convective precipitation cannot be sustained by evaporation within the domain, implying strong moisture transports into the tropical ocean area. While there is a decrease in net TOA radiation that develops after the peak in deep convective rainfall, there seems little evidence that an "Infrared Iris"- like mechanism is dominant. Rather, the cloud-induced OLR increase seems largely produced by weakened convection with warmer cloud tops. Tropical ISO events offer an accessible target for studying ISOs not just in terms of propagation mechanisms, but on their global signals of heat, moisture and radiative flux feedback processes.

  13. Validation of the RELAP5 code for the modeling of flashing-induced instabilities under natural-circulation conditions using experimental data from the CIRCUS test facility

    Energy Technology Data Exchange (ETDEWEB)

    Kozmenkov, Y. [Helmholtz-Zentrum Dresden-Rossendorf e.V. (FZD), Institute of Safety Research, P.O.B. 510119, D-01324 Dresden (Germany); Institute of Physics and Power Engineering, Obninsk (Russian Federation); Rohde, U., E-mail: U.Rohde@hzdr.de [Helmholtz-Zentrum Dresden-Rossendorf e.V. (FZD), Institute of Safety Research, P.O.B. 510119, D-01324 Dresden (Germany); Manera, A. [Paul Scherrer Institute (Switzerland)

    2012-02-15

    Highlights: Black-Right-Pointing-Pointer We report about the simulation of flashing-induced instabilities in natural circulation systems. Black-Right-Pointing-Pointer Flashing-induced instabilities are of relevance for operation of pool-type reactors of small power at low pressure. Black-Right-Pointing-Pointer The RELAP5 code is validated against measurement data from natural circulation experiments. Black-Right-Pointing-Pointer The magnitude and frequency of the oscillations were reproduced in good agreement with the measurement data. - Abstract: This paper reports on the use of the RELAP5 code for the simulation of flashing-induced instabilities in natural circulation systems. The RELAP 5 code is intended to be used for the simulation of transient processes in the Russian RUTA reactor concept operating at atmospheric pressure with forced convection of coolant. However, during transient processes, natural circulation with flashing-induced instabilities might occur. The RELAP5 code is validated against measurement data from natural circulation experiments performed within the framework of a European project (NACUSP) on the CIRCUS facility. The facility, built at the Delft University of Technology in The Netherlands, is a water/steam 1:1 height-scaled loop of a typical natural-circulation-cooled BWR. It was shown that the RELAP5 code is able to model all relevant phenomena related to flashing induced instabilities. The magnitude and frequency of the oscillations were reproduced in a good agreement with the measurement data. The close correspondence to the experiments was reached by detailed modeling of all components of the CIRCUS facility including the heat exchanger, the buffer vessel and the steam dome at the top of the facility.

  14. Cadmium-induced genomic instability in Arabidopsis: Molecular toxicological biomarkers for early diagnosis of cadmium stress.

    Science.gov (United States)

    Wang, Hetong; He, Lei; Song, Jie; Cui, Weina; Zhang, Yanzhao; Jia, Chunyun; Francis, Dennis; Rogers, Hilary J; Sun, Lizong; Tai, Peidong; Hui, Xiujuan; Yang, Yuesuo; Liu, Wan

    2016-05-01

    Microsatellite instability (MSI) analysis, random-amplified polymorphic DNA (RAPD), and methylation-sensitive arbitrarily primed PCR (MSAP-PCR) are methods to evaluate the toxicity of environmental pollutants in stress-treated plants and human cancer cells. Here, we evaluate these techniques to screen for genetic and epigenetic alterations of Arabidopsis plantlets exposed to 0-5.0 mg L(-1) cadmium (Cd) for 15 d. There was a substantial increase in RAPD polymorphism of 24.5, and in genomic methylation polymorphism of 30.5-34.5 at CpG and of 14.5-20 at CHG sites under Cd stress of 5.0 mg L(-1) by RAPD and of 0.25-5.0 mg L(-1) by MSAP-PCR, respectively. However, only a tiny increase of 1.5 loci by RAPD occurred under Cd stress of 4.0 mg L(-1), and an additional high dose (8.0 mg L(-1)) resulted in one repeat by MSI analysis. MSAP-PCR detected the most significant epigenetic modifications in plantlets exposed to Cd stress, and the patterns of hypermethylation and polymorphisms were consistent with inverted U-shaped dose responses. The presence of genomic methylation polymorphism in Cd-treated seedlings, prior to the onset of RAPD polymorphism, MSI and obvious growth effects, suggests that these altered DNA methylation loci are the most sensitive biomarkers for early diagnosis and risk assessment of genotoxic effects of Cd pollution in ecotoxicology. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Instability-induced ordering, universal unfolding and the role of gravity in granular Couette flow

    Science.gov (United States)

    Alam, Meheboob; Arakeri, V. H.; Nott, P. R.; Goddard, J. D.; Herrmann, H. J.

    2005-01-01

    Linear stability theory and bifurcation analysis are used to investigate the role of gravity in shear-band formation in granular Couette flow, considering a kinetic-theory rheological model. We show that the only possible state, at low shear rates, corresponds to a "plug" near the bottom wall, in which the particles are densely packed and the shear rate is close to zero, and a uniformly sheared dilute region above it. The origin of such plugged states is shown to be tied to the spontaneous symmetry-breaking instabilities of the gravity-free uniform shear flow, leading to the formation of ordered bands of alternating dilute and dense regions in the transverse direction, via an infinite hierarchy of pitchfork bifurcations. Gravity plays the role of an "imperfection", thus destroying the "perfect" bifurcation structure of uniform shear. The present bifurcation problem admits universal unfolding of pitchfork bifurcations which subsequently leads to the formation of a sequence of a countably infinite number of "isolas", with the solution structures being a modulated version of their gravity-free counterpart. While the solution with a plug near the bottom wall looks remarkably similar to the shear-banding phenomenon in dense slow granular Couette flows, a "floating" plug near the top wall is also a solution of these equations at high shear rates. A two-dimensional linear stability analysis suggests that these floating plugged states are unstable to long-wave travelling disturbances.The unique solution having a bottom plug can also be unstable to long waves, but remains stable at sufficiently low shear rates. The implications and realizability of the present results are discussed in the light of shear-cell experiments under "microgravity" conditions.

  16. The problem of induced genomic instability in the child organism under conditions of long-term effect of small radiation doses

    International Nuclear Information System (INIS)

    Suskov, I.I.; Kuz'mina, N.S.

    2001-01-01

    The phenomenological aspects of the genomic instability induced in the descendants of the multi-divided cells having been exposed to the radiation are examined. It is demonstrated that the regularity of the genomic instability induction do not correspond to the classical conception of the radiation genetics (hit principle and target theory). The mechanisms and the biological significance of this new genetic phenomenon in the child organism under conditions of low-intensive effect of small-dose radiation and its connection with the state of health are discussed [ru

  17. Irradiation-induced instability of MnS precipitates and its possible contribution to IASCC in light water reactors

    International Nuclear Information System (INIS)

    Garner, F.A.; Greenwood, L.R.; Chung, H.M.

    1997-01-01

    Although a number of candidate mechanisms have been proposed to participate in the IASCC phenomenon, it is not clear at this time that all of the contributing mechanisms have been identified. A new mechanism was proposed by Garner and Greenwood as a potential contribution to IASCC that involves the radiation-induced release into solution of sulphur and other deleterious elements that are normally concentrated into MnS precipitates. The instability arises from the combined action of the transmutation of manganese to iron, cascade-induced mixing and the very strong action of the inverse Kirkendall effect. The latter mechanism acts as a pump to export manganese from the precipitate surface and to replace it primarily with iron, as well as smaller amounts of chromium, nickel and other lesser elements. Evidence previously presented by Chung and coworkers appears to show that MnS precipitates in typical 300 series stainless steels become progressively depleted in manganese and enriched with iron as irradiation proceeds in boiling water reactor neutron spectra. It is shown in this paper that transmutation alone is insufficient to produce the observed behavior

  18. Radiation-induced hyperproliferation of intestinal crypts results in elevated genome instability with inactive p53-related genomic surveillance.

    Science.gov (United States)

    Zhou, Xin; Ma, Xiaofei; Wang, Zhenhua; Sun, Chao; Wang, Yupei; He, Yang; Zhang, Hong

    2015-12-15

    Radiation-induced hyperproliferation of intestinal crypts is well documented, but its potential tumorigenic effects remain elusive. Here we aim to determine the genomic surveillance process during crypt hyperproliferation, and its consequential outcome after ionizing radiation. Crypt regeneration in the intestine was induced by a single dose of 12Gy abdominal irradiation. γ-H2AX, 53BP1 and DNA-PKcs were used as DNA repair surrogates to investigate the inherent ability of intestinal crypt cells to recognize and repair double-strand breaks. Ki67 staining and the 5-bromo-2'-deoxyuridine incorporation assay were used to study patterns of cell proliferation in regenerating crypts. Staining for ATM, p53, Chk1 and Chk2 was performed to study checkpoint activation and release. Apoptosis was evaluated through H&E staining and terminal deoxynucleotidyl transferase (dUTP) nick-end labeling. The ATM-p53 pathway was immediately activated after irradiation. A second wave of DSBs in crypt cells was observed in regenerating crypts, accompanied with significantly increased chromosomal bridges. The p53-related genomic surveillance pathway was not active during the regeneration phase despite DSBs and chromosomal bridges in the cells of regenerating crypts. Non-homologous end joining (NHEJ) DSBs repair was involved in the DSBs repair process, as indicated by p-DNA-PKcs staining. Intestinal crypt cells retained hyperproliferation with inactive p53-related genomic surveillance system. NHEJ was involved in the resultant genomic instability during hyperproliferation. Copyright © 2015 Elsevier Inc. All rights reserved.

  19. A model for moisture-induced dimensional instability in printing paper

    NARCIS (Netherlands)

    van der Sman, C.G.; Bosco, E.; Peerlings, R.H.J.

    2016-01-01

    The dimensional stability of printing paper is strongly related to changes in moisture content. This represents a major issue in the field of digital ink-jet printing, where moisture induced reversible and irreversible deformations may compromise printing quality and runnability. This paper proposes

  20. Depletion-induced instability in protein-DNA mixtures: Influence of protein charge and size

    NARCIS (Netherlands)

    Vries, de R.J.

    2006-01-01

    While there is abundant experimental and theoretical work on polymer-induced DNA condensation, it is still unclear whether globular proteins can condense linear DNA or not. We develop a simple analytical approximation for the depletion attraction between rodlike segments of semiflexible

  1. Genomic instability and radiation

    Energy Technology Data Exchange (ETDEWEB)

    Little, John B [Harvard School of Public Health, Boston, MA 02115 (United States)

    2003-06-01

    Genomic instability is a hallmark of cancer cells, and is thought to be involved in the process of carcinogenesis. Indeed, a number of rare genetic disorders associated with a predisposition to cancer are characterised by genomic instability occurring in somatic cells. Of particular interest is the observation that transmissible instability can be induced in somatic cells from normal individuals by exposure to ionising radiation, leading to a persistent enhancement in the rate at which mutations and chromosomal aberrations arise in the progeny of the irradiated cells after many generations of replication. If such induced instability is involved in radiation carcinogenesis, it would imply that the initial carcinogenic event may not be a rare mutation occurring in a specific gene or set of genes. Rather, radiation may induce a process of instability in many cells in a population, enhancing the rate at which the multiple gene mutations necessary for the development of cancer may arise in a given cell lineage. Furthermore, radiation could act at any stage in the development of cancer by facilitating the accumulation of the remaining genetic events required to produce a fully malignant tumour. The experimental evidence for such induced instability is reviewed. (review)

  2. Genomic instability and radiation

    International Nuclear Information System (INIS)

    Little, John B

    2003-01-01

    Genomic instability is a hallmark of cancer cells, and is thought to be involved in the process of carcinogenesis. Indeed, a number of rare genetic disorders associated with a predisposition to cancer are characterised by genomic instability occurring in somatic cells. Of particular interest is the observation that transmissible instability can be induced in somatic cells from normal individuals by exposure to ionising radiation, leading to a persistent enhancement in the rate at which mutations and chromosomal aberrations arise in the progeny of the irradiated cells after many generations of replication. If such induced instability is involved in radiation carcinogenesis, it would imply that the initial carcinogenic event may not be a rare mutation occurring in a specific gene or set of genes. Rather, radiation may induce a process of instability in many cells in a population, enhancing the rate at which the multiple gene mutations necessary for the development of cancer may arise in a given cell lineage. Furthermore, radiation could act at any stage in the development of cancer by facilitating the accumulation of the remaining genetic events required to produce a fully malignant tumour. The experimental evidence for such induced instability is reviewed. (review)

  3. Laser-filamentation-induced water condensation and snow formation in a cloud chamber filled with different ambient gases.

    Science.gov (United States)

    Liu, Yonghong; Sun, Haiyi; Liu, Jiansheng; Liang, Hong; Ju, Jingjing; Wang, Tiejun; Tian, Ye; Wang, Cheng; Liu, Yi; Chin, See Leang; Li, Ruxin

    2016-04-04

    We investigated femtosecond laser-filamentation-induced airflow, water condensation and snow formation in a cloud chamber filled respectively with air, argon and helium. The mass of snow induced by laser filaments was found being the maximum when the chamber was filled with argon, followed by air and being the minimum with helium. We also discussed the mechanisms of water condensation in different gases. The results show that filaments with higher laser absorption efficiency, which result in higher plasma density, are beneficial for triggering intense airflow and thus more water condensation and precipitation.

  4. On the stability of a rod adhering to a rigid surface: Shear-induced stable adhesion and the instability of peeling

    Science.gov (United States)

    Majidi, Carmel; O'Reilly, Oliver M.; Williams, John A.

    2012-05-01

    Using variational methods, we establish conditions for the nonlinear stability of adhesive states between an elastica and a rigid halfspace. The treatment produces coupled criteria for adhesion and buckling instabilities by exploiting classical techniques from Legendre and Jacobi. Three examples that arise in a broad range of engineered systems, from microelectronics to biologically inspired fiber array adhesion, are used to illuminate the stability criteria. The first example illustrates buckling instabilities in adhered rods, while the second shows the instability of a peeling process and the third illustrates the stability of a shear-induced adhesion. The latter examples can also be used to explain how microfiber array adhesives can be activated by shearing and deactivated by peeling. The nonlinear stability criteria developed in this paper are also compared to other treatments.

  5. Radiation-induced instability of MnS precipitates and its possible consequences on IASCC of austenitic stainless steels

    International Nuclear Information System (INIS)

    Chung, H.M.; Garner, F.A.

    1996-01-01

    Irradiation assisted stress corrosion cracking (IASCC) continues to be a significant materials issue for the light water reactor industry and may also pose a problem for fusion power devices that employ water cooling. Although a number of potential mechanisms have been proposed to participate in this phenomenon, at this time it is not clear that any of these candidate mechanisms are sufficient to rationalize the observed failures. A new mechanism is proposed in this paper that involves the radiation-induced release into solution of elements not usually thought to participate in IASCC. It is shown in this paper that MnS precipitates, which contain most of the sulphur in stainless steels, are probably unstable under irradiation. First, the Mn transmutes very strongly to Fe in highly thermalized neutron spectra. Second, the combination of cascade-induced disordering and the inverse-Kirkendall effect operating at the incoherent interfaces of MnS precipitates will probably act as a pump to export Mn from the precipitate surface into the alloy matrix. Both of these processes will most likely allow some of the sulphur to re-enter the alloy matrix. Sulphur is known to exert a deleterious influence on grain boundary cracking. MnS precipitates are also thought to be a reservoir of other deleterious impurities such as fluorine which could be also released due to radiation-induced instability of the precipitates. This possibility has been confirmed by Auger electron spectroscopy of Types 304, 316, and 348 stainless steel specimens sectioned from several BWR components irradiated up to 3.5x10 21 n/cm 2 (E > 1 MeV)

  6. Radiation-induced instability of MnS precipitates and its possible consequences on IASCC of austenitic stainless steels

    Energy Technology Data Exchange (ETDEWEB)

    Chung, H.M. [Argonne National Lab., IL (United States); Garner, F.A. [Pacific Northwest National Lab., Richland, WA (United States)

    1996-10-01

    Irradiation assisted stress corrosion cracking (IASCC) continues to be a significant materials issue for the light water reactor industry and may also pose a problem for fusion power devices that employ water cooling. Although a number of potential mechanisms have been proposed to participate in this phenomenon, at this time it is not clear that any of these candidate mechanisms are sufficient to rationalize the observed failures. A new mechanism is proposed in this paper that involves the radiation-induced release into solution of elements not usually thought to participate in IASCC. It is shown in this paper that MnS precipitates, which contain most of the sulphur in stainless steels, are probably unstable under irradiation. First, the Mn transmutes very strongly to Fe in highly thermalized neutron spectra. Second, the combination of cascade-induced disordering and the inverse-Kirkendall effect operating at the incoherent interfaces of MnS precipitates will probably act as a pump to export Mn from the precipitate surface into the alloy matrix. Both of these processes will most likely allow some of the sulphur to re-enter the alloy matrix. Sulphur is known to exert a deleterious influence on grain boundary cracking. MnS precipitates are also thought to be a reservoir of other deleterious impurities such as fluorine which could be also released due to radiation-induced instability of the precipitates. This possibility has been confirmed by Auger electron spectroscopy of Types 304, 316, and 348 stainless steel specimens sectioned from several BWR components irradiated up to 3.5x10{sup 21} n/cm{sup 2} (E > 1 MeV).

  7. Interfacial instability induced by a shock wave in a gas-liquid horizontal stratified system

    International Nuclear Information System (INIS)

    Sutradhar, S.C.; Chang, J.S.; Yoshida, H.

    1987-01-01

    The experiments are performed in a rectangular lucite duct equipped with the facility of generating shock waves. Piezo-type pressure transducers are used to monitor the strength and propagation velocity of the shock wave. As the liquid phase has high sound velocity, a prepulse wave system of flow amplitude travels in this phase at a speed faster than the principal shock wave. The magnitude of the transmitted wave in the liquid phase is estimated using a transmission coefficient for gas-liquid system. From the initial pressure ratio of the shock wave, the amplitude of the prepulse as well as the induced interfacial fluid velocity are calculated. The wave length and height of the ripples during the passage of the shock wave are estimated for a specific strength of shock wave moving through the phases. From the high speed photographs, the wave length of the ripples can be assessed. The interfacial friction factor is calculated using colebrook's equation for high speed flow. At least five distinct phenomena are observed to exist during the propagation of a shock wave. These are - (1) the energy carried by the pre-pulse is utilized in perturbing the interface; (2) shock wave induces a mass velocity at the interface; (3) the wavelength of the ripples at the interface is the product of induced interfacial mass velocity and the time period of the prepulse; (4) a portion of the liquid mass of the perturbed interface is entrained in the gas phase may be due to the hydrodynamic lift in that phase; and finally (5) waves with long wavelength are established at the interface

  8. Hopf Bifurcation and Delay-Induced Turing Instability in a Diffusive lac Operon Model

    Science.gov (United States)

    Cao, Xin; Song, Yongli; Zhang, Tonghua

    In this paper, we investigate the dynamics of a lac operon model with delayed feedback and diffusion effect. If the system is without delay or the delay is small, the positive equilibrium is stable so that there are no spatial patterns formed; while the time delay is large enough the equilibrium becomes unstable so that rich spatiotemporal dynamics may occur. We have found that time delay can not only incur temporal oscillations but also induce imbalance in space. With different initial values, the system may have different spatial patterns, for instance, spirals with one head, four heads, nine heads, and even microspirals.

  9. Formation of Massive Molecular Cloud Cores by Cloud-cloud Collision

    OpenAIRE

    Inoue, Tsuyoshi; Fukui, Yasuo

    2013-01-01

    Recent observations of molecular clouds around rich massive star clusters including NGC3603, Westerlund 2, and M20 revealed that the formation of massive stars could be triggered by a cloud-cloud collision. By using three-dimensional, isothermal, magnetohydrodynamics simulations with the effect of self-gravity, we demonstrate that massive, gravitationally unstable, molecular cloud cores are formed behind the strong shock waves induced by the cloud-cloud collision. We find that the massive mol...

  10. Clonal evolution and progression of 20-methylcholanthrene-induced squamous cell carcinoma of mouse epidermis as revealed by DNA instability and other malignancy markers

    Directory of Open Access Journals (Sweden)

    K Hirai

    2009-12-01

    Full Text Available We examined the clonal evolution of skin malignant lesions by repeated topical applications of 20- methylcholanthrene (20-MC to the skin, which induces hyperplastic epidermis, papillomatous lesion and invasive carcinoma in mice. The lesions were examined histologically and immunohistochemically with anti-single-stranded DNA after acid hydrolysis (DNA-instability test, p53, VEGF, DFF45, PCNA and AgNORs parameters analyses. Multiple clones with increased DNA instability comparable to that of invasive carcinoma were noted in early-stage (2-6 weeks hyperplastic epidermis, and their number increased in middle (7-11 weeks, and late-stages (12-25 weeks of hyperplastic epidermis, indicating that they belong to the malignancy category. All papillomatous lesions and invasive carcinomas showed a positive DNA-instability test. Positive immunostaining for various biomarkers and AgNORs parameters appeared in clones with a positive DNA-instability test in earlyor middle-stage hyperplastic epidermis, and markedly increased in late-stage hyperplastic epidermis, papillomatous lesions and invasive carcinomas. The percentage of PCNA-positive vascular endothelial cells was significantly higher in VEGFpositive lesions with a positive DNA-instability test and became higher toward the late-stage of progression. Cut-woundings were made to papillomatous and invasive carcinoma lesions, and the regeneration activity of vascular endothelial cells was determined by using flash labeling with tritiated thymidine (3H-TdR. In small papillomatous lesions, vascular endothelial cells showed regenerative response, but the response was weak in large lesions. No such response was noted in invasive carcinomas; rather, cut-wounding induced collapse of blood vessels, which in turn induced massive coagulative necrosis of cancer cells. These responses can be interpreted to reflect exhausted vascular growth activity due to excessive stimulation by VEGF-overexpression, which was persistently

  11. Rayleigh convective instability in the presence of phase transitions of water vapor. The formation of large-scale eddies and cloud structures

    International Nuclear Information System (INIS)

    Shmerlin, Boris Ya; Kalashnik, Maksim V

    2013-01-01

    Convective motions in moist saturated air are accompanied by the release of latent heat of condensation. Taking this effect into account, we consider the problem of convective instability of a moist saturated air layer, generalizing the formulation of the classical Rayleigh problem. An analytic solution demonstrating the fundamental difference between moist convection and Rayleigh convection is obtained. Upon losing stability in the two-dimensional case, localized convective rolls or spatially periodic chains of rollers with localized areas of upward motion evolve. In the case of axial symmetry, the growth of localized convective vortices with circulation characteristic of tropical cyclones (hurricanes) is possible at the early stages of development and on the scale of tornados to tropical cyclones. (methodological notes)

  12. Merkel cell polyomavirus small T antigen induces genome instability by E3 ubiquitin ligase targeting.

    Science.gov (United States)

    Kwun, H J; Wendzicki, J A; Shuda, Y; Moore, P S; Chang, Y

    2017-12-07

    The formation of a bipolar mitotic spindle is an essential process for the equal segregation of duplicated DNA into two daughter cells during mitosis. As a result of deregulated cellular signaling pathways, cancer cells often suffer a loss of genome integrity that might etiologically contribute to carcinogenesis. Merkel cell polyomavirus (MCV) small T (sT) oncoprotein induces centrosome overduplication, aneuploidy, chromosome breakage and the formation of micronuclei by targeting cellular ligases through a sT domain that also inhibits MCV large T oncoprotein turnover. These results provide important insight as to how centrosome number and chromosomal stability can be affected by the E3 ligase targeting capacity of viral oncoproteins such as MCV sT, which may contribute to Merkel cell carcinogenesis.

  13. P53 Gene Mutation as Biomarker of Radiation Induced Cell Injury and Genomic Instability

    International Nuclear Information System (INIS)

    Mukh-Syaifudin

    2006-01-01

    Gene expression profiling and its mutation has become one of the most widely used approaches to identify genes and their functions in the context of identify and categorize genes to be used as radiation effect markers including cell and tissue sensitivities. Ionizing radiation produces genetic damage and changes in gene expression that may lead to cancer due to specific protein that controlling cell proliferation altered the function, its expression or both. P53 protein encoded by p53 gene plays an important role in protecting cell by inducing growth arrest and or cell suicide (apoptosis) after deoxyribonucleic acid (DNA) damage induced by mutagen such as ionizing radiation. The mutant and thereby dysfunctional of this gene was found in more than 50% of various human cancers, but it is as yet unclear how p53 mutations lead to neoplastic development. Wild-type p53 has been postulated to play a role in DNA repair, suggesting that expression of mutant forms of p53 might alter cellular resistance to the DNA damage caused by radiation. Moreover, p53 is thought to function as a cell cycle checkpoint after irradiation, also suggesting that mutant p53 might change the cellular proliferative response to radiation. P53 mutations affect the cellular response to DNA damage, either by increasing DNA repair processes or, possibly, by increasing cellular tolerance to DNA damage. The association of p53 mutations with increased radioresistance suggests that alterations in the p53 gene might lead to oncogenic transformation. Current attractive model of carcinogenesis also showed that p53 gene is the major target of radiation. The majority of p53 mutations found so far is single base pair changes ( point mutations), which result in amino acid substitutions or truncated forms of the p53 protein, and are widely distributed throughout the evolutionary conserved regions of the gene. Examination of p53 mutations in human cancer also shows an association between particular carcinogens and

  14. Chromosomal Instability and Molecular Defects in Induced Pluripotent Stem Cells from Nijmegen Breakage Syndrome Patients

    Directory of Open Access Journals (Sweden)

    Tomer Halevy

    2016-08-01

    Full Text Available Nijmegen breakage syndrome (NBS results from the absence of the NBS1 protein, responsible for detection of DNA double-strand breaks (DSBs. NBS is characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Here, we show successful reprogramming of NBS fibroblasts into induced pluripotent stem cells (NBS-iPSCs. Our data suggest a strong selection for karyotypically normal fibroblasts to go through the reprogramming process. NBS-iPSCs then acquire numerous chromosomal aberrations and show a delayed response to DSB induction. Furthermore, NBS-iPSCs display slower growth, mitotic inhibition, a reduced apoptotic response to stress, and abnormal cell-cycle-related gene expression. Importantly, NBS neural progenitor cells (NBS-NPCs show downregulation of neural developmental genes, which seems to be mediated by P53. Our results demonstrate the importance of NBS1 in early human development, shed light on the molecular mechanisms underlying this severe syndrome, and further expand our knowledge of the genomic stress cells experience during the reprogramming process.

  15. Mechanisms of thermally induced threshold voltage instability in GaN-based heterojunction transistors

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Shu; Liu, Shenghou; Liu, Cheng; Lu, Yunyou; Chen, Kevin J., E-mail: eekjchen@ust.hk [Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon (Hong Kong)

    2014-12-01

    In this work, we attempt to reveal the underlying mechanisms of divergent V{sub TH}-thermal-stabilities in III-nitride metal-insulator-semiconductor high-electron-mobility transistor (MIS-HEMT) and MOS-Channel-HEMT (MOSC-HEMT). In marked contrast to MOSC-HEMT featuring temperature-independent V{sub TH}, MIS-HEMT with the same high-quality gate-dielectric/III-nitride interface and similar interface trap distribution exhibits manifest thermally induced V{sub TH} shift. The temperature-dependent V{sub TH} of MIS-HEMT is attributed to the polarized III-nitride barrier layer, which spatially separates the critical gate-dielectric/III-nitride interface from the channel and allows “deeper” interface trap levels emerging above the Fermi level at pinch-off. This model is further experimentally validated by distinct V{sub G}-driven Fermi level movements at the critical interfaces in MIS-HEMT and MOSC-HEMT. The mechanisms of polarized III-nitride barrier layer in influencing V{sub TH}-thermal-stability provide guidelines for the optimization of insulated-gate III-nitride power switching devices.

  16. Mechanisms of thermally induced threshold voltage instability in GaN-based heterojunction transistors

    International Nuclear Information System (INIS)

    Yang, Shu; Liu, Shenghou; Liu, Cheng; Lu, Yunyou; Chen, Kevin J.

    2014-01-01

    In this work, we attempt to reveal the underlying mechanisms of divergent V TH -thermal-stabilities in III-nitride metal-insulator-semiconductor high-electron-mobility transistor (MIS-HEMT) and MOS-Channel-HEMT (MOSC-HEMT). In marked contrast to MOSC-HEMT featuring temperature-independent V TH , MIS-HEMT with the same high-quality gate-dielectric/III-nitride interface and similar interface trap distribution exhibits manifest thermally induced V TH shift. The temperature-dependent V TH of MIS-HEMT is attributed to the polarized III-nitride barrier layer, which spatially separates the critical gate-dielectric/III-nitride interface from the channel and allows “deeper” interface trap levels emerging above the Fermi level at pinch-off. This model is further experimentally validated by distinct V G -driven Fermi level movements at the critical interfaces in MIS-HEMT and MOSC-HEMT. The mechanisms of polarized III-nitride barrier layer in influencing V TH -thermal-stability provide guidelines for the optimization of insulated-gate III-nitride power switching devices

  17. Quantum-to-classical transition and gravity-induced instabilities (in progress)

    International Nuclear Information System (INIS)

    Lima, William C.C.

    2013-01-01

    Full text: It has been argued that gravitational fields produced by realistic matter distributions can induce the vacuum fluctuations of some non-minimally coupled free scalar field to go through a phase of exponential amplification. For the particular case of the formation of a neutron star, the energy density of the field in its initial vacuum state rivals the one of the star in a lapse of just a few milliseconds after the effect has been triggered. From this point on back reaction effects must be taken into account in order to predict the fate of both the star and scalar field. Classical analyses have shown that, at least for some values of the mass-radius ratio of the star and the non-minimal coupling parameter, a non-null scalar field profile could stabilize the system. The aim of our study is to shed some light on the back reaction process from the perspective of the quantum-to-classical transition that will occur once the classical background spacetime reacts to the unstable quantum field. In particular, the transition to a classical regime requires the specification of a well-defined classical initial state for the field. This can be accomplished analyzing the quantum state of the field around the time back reaction effects become important. (author)

  18. The collapse of interstellar gas clouds

    International Nuclear Information System (INIS)

    McNally, D.; Settle, J.J.

    1980-01-01

    The stability of spherically symmetric free-fall collapse to small radial perturbations is examined for non-uniform clouds. It is concluded that fragmentation of the central region of a collapsing gas cloud is possible if: (a) the density distribution is sufficiently smooth; and (b) the collapse is nearly free fall. Generally, perturbations enjoy only finite amplification during the collapse, and the amplification tends to decrease with increasing distance from the centre of the cloud. Unlimited amplification occurs only for uniform density clouds. Fragmentation is therefore unlikely to result from dynamical instability in the outer parts of a non-uniform cloud. Isothermal clouds are also briefly considered and, while it is argued that an earlier suggestion of their instability to fragmentation is unfounded, no general conclusion on the instability of such clouds could be drawn. (author)

  19. Making and Breaking Clouds

    Science.gov (United States)

    Kohler, Susanna

    2017-10-01

    Molecular clouds which youre likely familiar with from stunning popular astronomy imagery lead complicated, tumultuous lives. A recent study has now found that these features must be rapidly built and destroyed.Star-Forming CollapseA Hubble view of a molecular cloud, roughly two light-years long, that has broken off of the Carina Nebula. [NASA/ESA, N. Smith (University of California, Berkeley)/The Hubble Heritage Team (STScI/AURA)]Molecular gas can be found throughout our galaxy in the form of eminently photogenic clouds (as featured throughout this post). Dense, cold molecular gas makes up more than 20% of the Milky Ways total gas mass, and gravitational instabilities within these clouds lead them to collapse under their own weight, resulting in the formation of our galaxys stars.How does this collapse occur? The simplest explanation is that the clouds simply collapse in free fall, with no source of support to counter their contraction. But if all the molecular gas we observe collapsed on free-fall timescales, star formation in our galaxy would churn a rate thats at least an order of magnitude higher than the observed 12 solar masses per year in the Milky Way.Destruction by FeedbackAstronomers have theorized that there may be some mechanism that supports these clouds against gravity, slowing their collapse. But both theoretical studies and observations of the clouds have ruled out most of these potential mechanisms, and mounting evidence supports the original interpretation that molecular clouds are simply gravitationally collapsing.A sub-mm image from ESOs APEX telescope of part of the Taurus molecular cloud, roughly ten light-years long, superimposed on a visible-light image of the region. [ESO/APEX (MPIfR/ESO/OSO)/A. Hacar et al./Digitized Sky Survey 2. Acknowledgment: Davide De Martin]If this is indeed the case, then one explanation for our low observed star formation rate could be that molecular clouds are rapidly destroyed by feedback from the very stars

  20. Giant molecular cloud collisions as triggers of star formation. VI. Collision-induced turbulence

    Science.gov (United States)

    Wu, Benjamin; Tan, Jonathan C.; Nakamura, Fumitaka; Christie, Duncan; Li, Qi

    2018-05-01

    We investigate collisions between giant molecular clouds (GMCs) as potential generators of their internal turbulence. Using magnetohydrodynamic (MHD) simulations of self-gravitating, magnetized, turbulent GMCs, we compare kinematic and dynamic properties of dense gas structures formed when such clouds collide compared to those that form in non-colliding clouds as self-gravity overwhelms decaying turbulence. We explore the nature of turbulence in these structures via distribution functions of density, velocity dispersions, virial parameters, and momentum injection. We find that the dense clumps formed from GMC collisions have higher effective Mach number, greater overall velocity dispersions, sustain near-virial equilibrium states for longer times, and are the conduit for the injection of turbulent momentum into high density gas at high rates.

  1. Laser-filament-induced snow formation in a subsaturated zone in a cloud chamber: experimental and theoretical study.

    Science.gov (United States)

    Ju, Jingjing; Sun, Haiyi; Sridharan, Aravindan; Wang, Tie-Jun; Wang, Cheng; Liu, Jiansheng; Li, Ruxin; Xu, Zhizhan; Chin, See Leang

    2013-12-01

    1 kHz, 2 mJ, 45 fs, 800 nm laser pulses were fired into a laboratory diffusion cloud chamber through a subsaturated zone (relative humidity ∼73%, T ∼ 4.3 °C). After 60 min of laser irradiation, an oval-shaped snow pile was observed right below the filament center and weighed ∼12.0 mg. The air current velocity at the edge of the vortices was estimated to be ∼16.5 cm/s. Scattering scenes recorded from the side show that filament-induced turbulence were formed inside the cloud chamber with two vortices below the filament. Two-dimensional simulations of the air flow motion in two cross sections of the cloud chamber confirm that the turbulent vortices exist below the filament. Based upon this simulation, we deduce that the vortices indeed have a three-dimensional elliptical shape. Hence, we propose that inside vortices where the humidity was supersaturated or saturated the condensation nuclei, namely, HNO(3), N(2)(+), O(2)(+) and other aerosols and impurities, were activated and grew in size. Large-sized particles would eventually be spun out along the fast moving direction towards the cold plate and formed an oval-shaped snow pile at the end.

  2. Enhanced micronucleus formation in the descendants of {gamma}-ray-irradiated tobacco cells: Evidence for radiation-induced genomic instability in plant cells

    Energy Technology Data Exchange (ETDEWEB)

    Yokota, Yuichiro, E-mail: yokota.yuichiro@jaea.go.jp [Life Science and Biotechnology Division, Quantum Beam Science Directorate, Japan Atomic Energy Agency, 1233 Watanuki-machi, Takasaki, Gunma 370-1292 (Japan); Funayama, Tomoo; Hase, Yoshihiro [Life Science and Biotechnology Division, Quantum Beam Science Directorate, Japan Atomic Energy Agency, 1233 Watanuki-machi, Takasaki, Gunma 370-1292 (Japan); Hamada, Nobuyuki [Radiation Safety Research Center, Nuclear Technology Research Laboratory, Central Research Institute of Electric Power Industry, 2-11-1 Iwado-kita, Komae, Tokyo 201-8511 (Japan); Kobayashi, Yasuhiko; Tanaka, Atsushi; Narumi, Issay [Life Science and Biotechnology Division, Quantum Beam Science Directorate, Japan Atomic Energy Agency, 1233 Watanuki-machi, Takasaki, Gunma 370-1292 (Japan)

    2010-09-10

    Ionizing radiation-induced genomic instability has been documented in various end points such as chromosomal aberrations and mutations, which arises in the descendants of irradiated mammalian or yeast cells many generations after the initial insult. This study aimed at addressing radiation-induced genomic instability in higher plant tobacco cells. We thus investigated micronucleus (MN) formation and cell proliferation in tobacco cells irradiated with {gamma}-rays and their descendants. In {gamma}-irradiated cells, cell cycle was arrested at G{sub 2}/M phase at around 24 h post-irradiation but released afterward. In contrast, MN frequency peaked at 48 h post-irradiation. Almost half of 40 Gy-irradiated cells had MN at 48 h post-irradiation, but proliferated as actively as sham-irradiated cells up to 120 h post-irradiation. Moreover, the descendants that have undergone at least 22 generations after irradiation still showed a two-fold MN frequency compared to sham-irradiated cells. This is the direct evidence for radiation-induced genomic instability in tobacco cells.

  3. The moyamoya disease susceptibility variant RNF213 R4810K (rs112735431) induces genomic instability by mitotic abnormality

    Energy Technology Data Exchange (ETDEWEB)

    Hitomi, Toshiaki [Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Habu, Toshiyuki [Radiation Biology Center, Kyoto University, Kyoto (Japan); Kobayashi, Hatasu; Okuda, Hiroko; Harada, Kouji H. [Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Osafune, Kenji [Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto (Japan); Taura, Daisuke; Sone, Masakatsu [Department of Medicine and Clinical Science, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Asaka, Isao; Ameku, Tomonaga; Watanabe, Akira; Kasahara, Tomoko; Sudo, Tomomi; Shiota, Fumihiko [Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto (Japan); Hashikata, Hirokuni; Takagi, Yasushi [Department of Neurosurgery, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Morito, Daisuke [Faculty of Life Sciences, Kyoto Sangyo University, Kyoto (Japan); Miyamoto, Susumu [Department of Neurosurgery, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Nakao, Kazuwa [Department of Medicine and Clinical Science, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Koizumi, Akio, E-mail: koizumi.akio.5v@kyoto-u.ac.jp [Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto (Japan)

    2013-10-04

    Highlights: •Overexpression of RNF213 R4810K inhibited cell proliferation. •Overexpression of RNF213 R4810K had the time of mitosis 4-fold and mitotic failure. •R4810K formed a complex with MAD2 more readily than wild-type. •iPSECs from the MMD patients had elevated mitotic failure compared from the control. •RNF213 R4810K induced mitotic abnormality and increased risk of aneuploidy. -- Abstract: Moyamoya disease (MMD) is a cerebrovascular disease characterized by occlusive lesions in the Circle of Willis. The RNF213 R4810K polymorphism increases susceptibility to MMD. In the present study, we characterized phenotypes caused by overexpression of RNF213 wild type and R4810K variant in the cell cycle to investigate the mechanism of proliferation inhibition. Overexpression of RNF213 R4810K in HeLa cells inhibited cell proliferation and extended the time of mitosis 4-fold. Ablation of spindle checkpoint by depletion of mitotic arrest deficiency 2 (MAD2) did not shorten the time of mitosis. Mitotic morphology in HeLa cells revealed that MAD2 colocalized with RNF213 R4810K. Immunoprecipitation revealed an RNF213/MAD2 complex: R4810K formed a complex with MAD2 more readily than RNF213 wild-type. Desynchronized localization of MAD2 was observed more frequently during mitosis in fibroblasts from patients (n = 3, 61.0 ± 8.2%) compared with wild-type subjects (n = 6, 13.1 ± 7.7%; p < 0.01). Aneuploidy was observed more frequently in fibroblasts (p < 0.01) and induced pluripotent stem cells (iPSCs) (p < 0.03) from patients than from wild-type subjects. Vascular endothelial cells differentiated from iPSCs (iPSECs) of patients and an unaffected carrier had a longer time from prometaphase to metaphase than those from controls (p < 0.05). iPSECs from the patients and unaffected carrier had significantly increased mitotic failure rates compared with controls (p < 0.05). Thus, RNF213 R4810K induced mitotic abnormalities and increased risk of genomic instability.

  4. The moyamoya disease susceptibility variant RNF213 R4810K (rs112735431) induces genomic instability by mitotic abnormality

    International Nuclear Information System (INIS)

    Hitomi, Toshiaki; Habu, Toshiyuki; Kobayashi, Hatasu; Okuda, Hiroko; Harada, Kouji H.; Osafune, Kenji; Taura, Daisuke; Sone, Masakatsu; Asaka, Isao; Ameku, Tomonaga; Watanabe, Akira; Kasahara, Tomoko; Sudo, Tomomi; Shiota, Fumihiko; Hashikata, Hirokuni; Takagi, Yasushi; Morito, Daisuke; Miyamoto, Susumu; Nakao, Kazuwa; Koizumi, Akio

    2013-01-01

    Highlights: •Overexpression of RNF213 R4810K inhibited cell proliferation. •Overexpression of RNF213 R4810K had the time of mitosis 4-fold and mitotic failure. •R4810K formed a complex with MAD2 more readily than wild-type. •iPSECs from the MMD patients had elevated mitotic failure compared from the control. •RNF213 R4810K induced mitotic abnormality and increased risk of aneuploidy. -- Abstract: Moyamoya disease (MMD) is a cerebrovascular disease characterized by occlusive lesions in the Circle of Willis. The RNF213 R4810K polymorphism increases susceptibility to MMD. In the present study, we characterized phenotypes caused by overexpression of RNF213 wild type and R4810K variant in the cell cycle to investigate the mechanism of proliferation inhibition. Overexpression of RNF213 R4810K in HeLa cells inhibited cell proliferation and extended the time of mitosis 4-fold. Ablation of spindle checkpoint by depletion of mitotic arrest deficiency 2 (MAD2) did not shorten the time of mitosis. Mitotic morphology in HeLa cells revealed that MAD2 colocalized with RNF213 R4810K. Immunoprecipitation revealed an RNF213/MAD2 complex: R4810K formed a complex with MAD2 more readily than RNF213 wild-type. Desynchronized localization of MAD2 was observed more frequently during mitosis in fibroblasts from patients (n = 3, 61.0 ± 8.2%) compared with wild-type subjects (n = 6, 13.1 ± 7.7%; p < 0.01). Aneuploidy was observed more frequently in fibroblasts (p < 0.01) and induced pluripotent stem cells (iPSCs) (p < 0.03) from patients than from wild-type subjects. Vascular endothelial cells differentiated from iPSCs (iPSECs) of patients and an unaffected carrier had a longer time from prometaphase to metaphase than those from controls (p < 0.05). iPSECs from the patients and unaffected carrier had significantly increased mitotic failure rates compared with controls (p < 0.05). Thus, RNF213 R4810K induced mitotic abnormalities and increased risk of genomic instability

  5. Relativistic gravitational instabilities

    International Nuclear Information System (INIS)

    Schutz, B.F.

    1987-01-01

    The purpose of these lectures is to review and explain what is known about the stability of relativistic stars and black holes, with particular emphases on two instabilities which are due entirely to relativistic effects. The first of these is the post-Newtonian pulsational instability discovered independently by Chandrasekhar (1964) and Fowler (1964). This effectively ruled out the then-popular supermassive star model for quasars, and it sets a limit to the central density of white dwarfs. The second instability was also discovered by Chandrasekhar (1970): the gravitational wave induced instability. This sets an upper bound on the rotation rate of neutron stars, which is near that of the millisecond pulsar PSR 1937+214, and which is beginning to constrain the equation of state of neutron matter. 111 references, 5 figures

  6. Infrared rotational light curves on Jupiter induced by wave activities and cloud patterns andimplications on brown dwarfs

    Science.gov (United States)

    Ge, Huazhi; Zhang, Xi; Fletcher, Leigh; Orton, Glenn S.; Sinclair, James Andrew; Fernandes,, Joshua; Momary, Thomas W.; Warren, Ari; Kasaba, Yasumasa; Sato, Takao M.; Fujiyoshi, Takuya

    2017-10-01

    Many brown dwarfs exhibit infrared rotational light curves with amplitude varying from a fewpercent to twenty percent (Artigau et al. 2009, ApJ, 701, 1534; Radigan et al. 2012, ApJ, 750,105). Recently, it was claimed that weather patterns, especially planetary-scale waves in thebelts and cloud spots, are responsible for the light curves and their evolutions on brown dwarfs(Apai et al. 2017, Science, 357, 683). Here we present a clear relationship between the direct IRemission maps and light curves of Jupiter at multiple wavelengths, which might be similar withthat on cold brown dwarfs. Based on infrared disk maps from Subaru/COMICS and VLT/VISIR,we constructed full maps of Jupiter and rotational light curves at different wavelengths in thethermal infrared. We discovered a strong relationship between the light curves and weatherpatterns on Jupiter. The light curves also exhibit strong multi-bands phase shifts and temporalvariations, similar to that detected on brown dwarfs. Together with the spectra fromTEXES/IRTF, our observations further provide detailed information of the spatial variations oftemperature, ammonia clouds and aerosols in the troposphere of Jupiter (Fletcher et al. 2016,Icarus, 2016 128) and their influences on the shapes of the light curves. We conclude that waveactivities in Jupiter’s belts (Fletcher et al. 2017, GRL, 44, 7140), cloud holes, and long-livedvortices such as the Great Red Spot and ovals control the shapes of IR light curves and multi-wavelength phase shifts on Jupiter. Our finding supports the hypothesis that observed lightcurves on brown dwarfs are induced by planetary-scale waves and cloud spots.

  7. Radiation-induced instability of MnS precipitates and its possible consequences on irradiation-induced stress corrosion cracking of austenitic stainless steels

    International Nuclear Information System (INIS)

    Chung, H.M.; Sanecki, J.E.; Garner, F.A.

    1996-12-01

    Irradiation-assisted stress corrosion cracking (IASCC) is a significant materials issue for the light water reactor (LWR) industry and may also pose a problem for fusion power reactors that will use water as coolant. A new metallurgical process is proposed that involves the radiation-induced release into solution of minor impurity elements not usually thought to participate in IASCC. MnS-type precipitates, which contain most of the sulfur in stainless steels, are thought to be unstable under irradiation. First, Mn transmutes strongly to Fe in thermalized neutron spectra. Second, cascade-induced disordering and the inverse Kirkendall effect operating at the incoherent interfaces of MnS precipitates are thought to act as a pump to export Mn from the precipitate into the alloy matrix. Both of these processes will most likely allow sulfur, which is known to exert a deleterious influence on intergranular cracking, to re-enter the matrix. To test this hypothesis, compositions of MnS-type precipitates contained in several unirradiated and irradiated heats of Type 304, 316, and 348 stainless steels (SSs) were analyzed by Auger electron spectroscopy. Evidence is presented that shows a progressive compositional modification of MnS precipitates as exposure to neutrons increases in boiling water reactors. As the fluence increases, the Mn level in MnS decreases, whereas the Fe level increases. The S level also decreases relative to the combined level of Mn and Fe. MnS precipitates were also found to be a reservoir of other deleterious impurities such as F and O which could be also released due to radiation-induced instability of the precipitates

  8. Comparison of the coherent radiation-induced microbunching instability in a free-electron laser and a magnetic chicane

    Directory of Open Access Journals (Sweden)

    S. Reiche

    2003-04-01

    Full Text Available A self-amplified spontaneous emission free-electron laser (SASE FEL is a device which is based on the creation of a very intense, relativistic electron beam which has very little temperature in all three phase planes. The beam in this system is described as having “high brightness,” and when it is bent repetitively in a magnetic undulator, undergoes a radiation-mediated microbunching instability. This instability can amplify the original radiation amplitude at a particular, resonant wavelength by many orders of magnitude. In order to obtain high brightness beams, it is necessary to compress them to obtain higher currents than available from the electron source. Compression is accomplished by the use of magnetic chicanes, which are quite similar to, if much longer than, a single period of the undulator. It should not be surprising that such chicanes also support a radiation-mediated microbunching interaction, which has recently been investigated, and has been termed coherent synchrotron radiation (CSR instability. The purpose of this paper is to compare and contrast the characteristics of the closely related FEL and CSR microbunching instabilities. We show that a high-gain regime of the CSR instability exists which is formally similar to the FEL instability.

  9. Two-stream instability in pulsar magnetospheres

    International Nuclear Information System (INIS)

    Usov, V.V.

    1987-01-01

    If the electron-positron plasma flow from the pulsar environment is stationary, the two-stream instability does not have enough time to develop in the pulsar magnetosphere. In that case the outflowing electron-positron plasma gathers into separate clouds. The clouds move along magnetic field lines and disperse as they go farther from the pulsar. At a distance of about 10 to the 8th cm from the pulsar surface, the high-energy particles of a given cloud catch up with the low-energy particles that belong to the cloud going ahead of it. In this region of a pulsar magnetosphere, the energy distribution of plasma particles is two-humped, and a two-stream instability may develop. The growth rate of the instability is quite sufficient for its development. 17 references

  10. Aerosol indirect effect from turbulence-induced broadening of cloud-droplet size distributions

    Energy Technology Data Exchange (ETDEWEB)

    Chandrakar, Kamal Kant; Cantrell, Will; Chang, Kelken; Ciochetto, David; Niedermeier, Dennis; Ovchinnikov, Mikhail; Shaw, Raymond A.; Yang, Fan

    2016-11-28

    The influence of aerosol concentration on cloud droplet size distribution is investigated in a laboratory chamber that enables turbulent cloud formation through moist convection. The experiments allow steady-state microphysics to be achieved, with aerosol input balanced by cloud droplet growth and fallout. As aerosol concentration is increased the cloud droplet mean diameter decreases as expected, but the width of the size distribution also decreases sharply. The aerosol input allows for cloud generation in the limiting regimes of fast microphysics (τc < τt) for high aerosol concentration, and slow microphysics (τc > τt) for low aerosol concentration; here, τc is the phase relaxation time and τt is the turbulence correlation time. The increase in the width of the droplet size distribution for the low aerosol limit is consistent with larger variability of supersaturation due to the slow microphysical response. A stochastic differential equation for supersaturation predicts that the standard deviation of the squared droplet radius should increase linearly with a system time scale defined as τs-1c-1 + τt-1, and the measurements are in excellent agreement with this finding. This finding underscores the importance of droplet size dispersion for the aerosol indirect effect: increasing aerosol concentration not only suppresses precipitation formation through reduction of the mean droplet diameter, but perhaps more importantly, through narrowing of the droplet size distribution due to reduced supersaturation fluctuations. Supersaturation fluctuations in the low aerosol / slow microphysics limit are likely of leading importance for precipitation formation.

  11. Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro

    Science.gov (United States)

    Morgan, William F.

    2003-01-01

    A long-standing dogma in the radiation sciences is that energy from radiation must be deposited in the cell nucleus to elicit a biological effect. A number of non-targeted, delayed effects of ionizing radiation have been described that challenge this dogma and pose new challenges to evaluating potential hazards associated with radiation exposure. These effects include induced genomic instability and non-targeted bystander effects. The in vitro evidence for non-targeted effects in radiation biology will be reviewed, but the question as to how one extrapolates from these in vitro observations to the risk of radiation-induced adverse health effects such as cancer remains open.

  12. On cloud ice induced absorption and polarisation effects in microwave limb sounding

    Directory of Open Access Journals (Sweden)

    P. Eriksson

    2011-06-01

    Full Text Available Microwave limb sounding in the presence of ice clouds was studied by detailed simulations, where clouds and other atmospheric variables varied in three dimensions and the full polarisation state was considered. Scattering particles were assumed to be horizontally aligned oblate spheroids with a size distribution parameterized in terms of temperature and ice water content. A general finding was that particle absorption is significant for limb sounding, which is in contrast to the down-looking case, where it is usually insignificant. Another general finding was that single scattering can be assumed for cloud optical paths below about 0.1, which is thus an important threshold with respect to the complexity and accuracy of retrieval algorithms. The representation of particle sizes during the retrieval is also discussed. Concerning polarisation, specific findings were as follows: Firstly, no significant degree of circular polarisation was found for the considered particle type. Secondly, for the ±45° polarisation components, differences of up to 4 K in brightness temperature were found, but differences were much smaller when single scattering conditions applied. Thirdly, the vertically polarised component has the smallest cloud extinction. An important goal of the study was to derive recommendations for future limb sounding instruments, particularly concerning their polarisation setup. If ice water content is among the retrieval targets (and not just trace gas mixing ratios, then the simulations show that it should be best to observe any of the ±45° and circularly polarised components. These pairs of orthogonal components also make it easier to combine information measured from different positions and with different polarisations.

  13. Chemical complexity induced by efficient ice evaporation in the Barnard 5 molecular cloud

    OpenAIRE

    Taquet, Vianney; Wirström, Eva; Charnley, Steven B.; Faure, Alexandre; López-Sepulcre, Ana; Persson, Carina M.

    2017-01-01

    Cold gas-phase water has recently been detected in a cold dark cloud, Barnard 5 located in the Perseus complex, by targeting methanol peaks as signposts for ice mantle evaporation. Observed morphology and abundances of methanol and water are consistent with a transient non-thermal evaporation process only affecting the outermost ice mantle layers, possibly triggering a more complex chemistry. We present the detection of the Complex Organic Molecules (COMs) acetaldehyde and methyl formate as w...

  14. Potential risk of acute toxicity induced by AgI cloud seeding on soil and freshwater biota.

    Science.gov (United States)

    Fajardo, C; Costa, G; Ortiz, L T; Nande, M; Rodríguez-Membibre, M L; Martín, M; Sánchez-Fortún, S

    2016-11-01

    Silver iodide is one of the most common nucleating materials used in cloud seeding. Previous cloud seeding studies have concluded that AgI is not practically bioavailable in the environment but instead remains in soils and sediments such that the free Ag amounts are likely too low to induce a toxicological effect. However, none of these studies has considered the continued use of this practice on the same geographical areas and thus the potential cumulative effect of environmental AgI. The aim of this study is to assess the risk of acute toxicity caused by AgI exposure under laboratory conditions at the concentration expected in the environment after repeated treatments on selected soil and aquatic biota. To achieve the aims, the viability of soil bacteria Bacillus cereus and Pseudomonas stutzeri and the survival of the nematode Caenorhabditis elegans exposed to different silver iodide concentrations have been evaluated. Freshwater green algae Dictyosphaerium chlorelloides and cyanobacteria Microcystis aeruginosa were exposed to silver iodide in culture medium, and their cell viability and photosynthetic activity were evaluated. Additionally, BOD5 exertion and the Microtox® toxicity test were included in the battery of toxicological assays. Both tests exhibited a moderate AgI adverse effect at the highest concentration (12.5µM) tested. However, AgI concentrations below 2.5µM increased BOD5. Although no impact on the growth and survival endpoints in the soil worm C. elegans was recorded after AgI exposures, a moderate decrease in cell viability was found for both of the assessed soil bacterial strains at the studied concentrations. Comparison between the studied species showed that the cyanobacteria were more sensitive than green algae. Exposure to AgI at 0.43μM, the reference value used in monitoring environmental impact, induced a significant decrease in photosynthetic activity that is primarily associated with the respiration (80% inhibition) and, to a lesser

  15. Carpal instability

    International Nuclear Information System (INIS)

    Schmitt, R.; Froehner, S.; Coblenz, G.; Christopoulos, G.

    2006-01-01

    This review addresses the pathoanatomical basics as well as the clinical and radiological presentation of instability patterns of the wrist. Carpal instability mostly follows an injury; however, other diseases, like CPPD arthropathy, can be associated. Instability occurs either if the carpus is unable to sustain physiologic loads (''dyskinetics'') or suffers from abnormal motion of its bones during movement (''dyskinematics''). In the classification of carpal instability, dissociative subcategories (located within proximal carpal row) are differentiated from non-dissociative subcategories (present between the carpal rows) and combined patterns. It is essential to note that the unstable wrist initially does not cause relevant signs in standard radiograms, therefore being ''occult'' for the radiologic assessment. This paper emphasizes the high utility of kinematographic studies, contrast-enhanced magnetic resonance imaging (MRI) and MR arthrography for detecting these predynamic and dynamic instability stages. Later in the natural history of carpal instability, static malalignment of the wrist and osteoarthritis will develop, both being associated with significant morbidity and disability. To prevent individual and socio-economic implications, the handsurgeon or orthopedist, as well as the radiologist, is challenged for early and precise diagnosis. (orig.)

  16. Gravitational Instabilities in Circumstellar Disks

    Science.gov (United States)

    Kratter, Kaitlin; Lodato, Giuseppe

    2016-09-01

    Star and planet formation are the complex outcomes of gravitational collapse and angular momentum transport mediated by protostellar and protoplanetary disks. In this review, we focus on the role of gravitational instability in this process. We begin with a brief overview of the observational evidence for massive disks that might be subject to gravitational instability and then highlight the diverse ways in which the instability manifests itself in protostellar and protoplanetary disks: the generation of spiral arms, small-scale turbulence-like density fluctuations, and fragmentation of the disk itself. We present the analytic theory that describes the linear growth phase of the instability supplemented with a survey of numerical simulations that aim to capture the nonlinear evolution. We emphasize the role of thermodynamics and large-scale infall in controlling the outcome of the instability. Despite apparent controversies in the literature, we show a remarkable level of agreement between analytic predictions and numerical results. In the next part of our review, we focus on the astrophysical consequences of the instability. We show that the disks most likely to be gravitationally unstable are young and relatively massive compared with their host star, Md/M*≥0.1. They will develop quasi-stable spiral arms that process infall from the background cloud. Although instability is less likely at later times, once infall becomes less important, the manifestations of the instability are more varied. In this regime, the disk thermodynamics, often regulated by stellar irradiation, dictates the development and evolution of the instability. In some cases the instability may lead to fragmentation into bound companions. These companions are more likely to be brown dwarfs or stars than planetary mass objects. Finally, we highlight open questions related to the development of a turbulent cascade in thin disks and the role of mode-mode coupling in setting the maximum angular

  17. Genomic instability induced in distant progeny of bystander cells depends on the connexins expressed in the irradiated cells.

    Science.gov (United States)

    de Toledo, Sonia M; Buonanno, Manuela; Harris, Andrew L; Azzam, Edouard I

    2017-10-01

    To examine the time window during which intercellular signaling though gap junctions mediates non-targeted (bystander) effects induced by moderate doses of ionizing radiation; and to investigate the impact of gap junction communication on genomic instability in distant progeny of bystander cells. A layered cell culture system was developed to investigate the propagation of harmful effects from irradiated normal or tumor cells that express specific connexins to contiguous bystander normal human fibroblasts. Irradiated cells were exposed to moderate mean absorbed doses from 3.7 MeV α particle, 1000 MeV/u iron ions, 600 MeV/u silicon ions, or 137 Cs γ rays. Following 5 h of co-culture, pure populations of bystander cells, unexposed to secondary radiation, were isolated and DNA damage and oxidative stress was assessed in them and in their distant progeny (20-25 population doublings). Increased frequency of micronucleus formation and enhanced oxidative changes were observed in bystander cells co-cultured with confluent cells exposed to either sparsely ionizing ( 137 Cs γ rays) or densely ionizing (α particles, energetic iron or silicon ions) radiations. The irradiated cells propagated signals leading to biological changes in bystander cells within 1 h of irradiation, and the effect required cellular coupling by gap junctions. Notably, the distant progeny of isolated bystander cells also exhibited increased levels of spontaneous micronuclei. This effect was dependent on the type of junctional channels that coupled the irradiated donor cells with the bystander cells. Previous work showed that gap junctions composed of connexin26 (Cx26) or connexin43 (Cx43) mediate toxic bystander effects within 5 h of co-culture, whereas gap junctions composed of connexin32 (Cx32) mediate protective effects. In contrast, the long-term progeny of bystander cells expressing Cx26 or Cx43 did not display elevated DNA damage, whereas those coupled by Cx32 had enhanced DNA

  18. ULTRAVIOLET INDUCED MOTION OF A FLUORESCENT DUST CLOUD IN AN ARGON DIRECT CURRENT GLOW DISCHARGE PLASMA

    Energy Technology Data Exchange (ETDEWEB)

    Hvasta, M.G.; and Zwicker, A.

    2008-01-01

    Dusty plasmas consist of electrons, ions, neutrals and nm-μm sized particles commonly referred to as dust. In man-made plasmas this dust may represent impurities in a tokamak or plasma etching processing. In astrophysical plasmas this dust forms structures such as planetary rings and comet tails. To study dusty plasma dynamics an experiment was designed in which a 3:1 silica (<5 μm diameter) and fl uorescent dust mixture was added to an argon DC glow discharge plasma and exposed to UV radiation. This fl uorescent lighting technique offers an advantage over laser scattering (which only allows two-dimensional slices of the cloud to be observed) and is simpler than scanning mirror techniques or particle image velocimetry. Under typical parameters (P=150 mTorr, V anode= 100 V, Vcathode= -400 V, Itotal < 2mA) when the cloud is exposed to the UV light (100W, λ = 365 nm) the mixture fl uoresces, moves ~2mm towards the light source and begins rotating in a clockwise manner (as seen from the cathode). By calibrating a UV lamp and adjusting the relative intensity of the UV with a variable transformer it was found that both translational and rotational velocities are a function of UV intensity. Additionally, it was determined that bulk cloud rotation is not seen when the dust tray is not grounded while bulk translation is. This ongoing experiment represents a novel way to control contamination in man-made plasmas and a path to a better understanding of UV-bathed plasma systems in space..

  19. Collisionless Kelvin-Helmholtz instability and vortex-induced reconnection in the external region of the Earth magnetotail

    International Nuclear Information System (INIS)

    Pegoraro, F; Faganello, M; Califano, F

    2008-01-01

    In a magnetized plasma streaming with a non uniform velocity, the Kelvin-Helmholtz instability plays a major role in mixing different plasma regions and in stretching the magnetic field lines leading to the formation of layers with a sheared magnetic field where magnetic field line reconnection can take place. A relevant example is provided by the formation of a mixing layer between the Earth's magnetosphere and the solar wind at low latitudes during northward periods. In the considered configuration, in the presence of a magnetic field nearly perpendicular to the plane defined by the velocity field and its inhomogeneity direction, velocity shear drives a Kelvin-Helmholtz instability which advects and distorts the magnetic field configuration. If the Alfven velocity associated to the in-plane magnetic field is sufficiently weak with respect to the variation of the fluid velocity in the plasma, the Kelvin-Helmholtz instability generates fully rolled-up vortices which advect the magnetic field lines into a complex configuration, causing the formation of current layers along the inversion curves of the in-plane magnetic field component. Pairing of the vortices generated by the Kelvin-Helmholtz instability is a well know phenomenon in two-dimensional hydrodynamics. Here we investigate the development of magnetic reconnection during the vortex pairing process and show that completely different magnetic structures are produced depending on how fast the reconnection process develops on the time scale set by the pairing process.

  20. Causes of genome instability

    DEFF Research Database (Denmark)

    Langie, Sabine A S; Koppen, Gudrun; Desaulniers, Daniel

    2015-01-01

    function, chromosome segregation, telomere length). The purpose of this review is to describe the crucial aspects of genome instability, to outline the ways in which environmental chemicals can affect this cancer hallmark and to identify candidate chemicals for further study. The overall aim is to make......Genome instability is a prerequisite for the development of cancer. It occurs when genome maintenance systems fail to safeguard the genome's integrity, whether as a consequence of inherited defects or induced via exposure to environmental agents (chemicals, biological agents and radiation). Thus...

  1. A photoionization instability in the early intergalactic medium

    Science.gov (United States)

    Hogan, Craig J.

    1992-01-01

    It is argued that any fairly uniform source of ionizing photons can be the cause of an instability in the pregalactic medium on scales larger than a photon path length. Underdense regions receive more ionizing energy per atom and reach higher temperature and entropy, driving the density down still further. Fluctuations created by this instability can lead to the formation of structures resembling protogalaxies and intergalactic clouds, obviating the need for gas clouds or density perturbations of earlier cosmological provenance, as is usually assumed in theories of galaxy and structure formation. Characteristic masses for clouds produced by the instability, with log mass in solar units plotted against log radius in kpc, are illustrated.

  2. Molecular clouds near supernova remnants

    International Nuclear Information System (INIS)

    Wootten, H.A.

    1978-01-01

    The physical properties of molecular clouds near supernova remnants were investigated. Various properties of the structure and kinematics of these clouds are used to establish their physical association with well-known remmnants. An infrared survey of the most massive clouds revealed embedded objects, probably stars whose formation was induced by the supernova blast wave. In order to understand the relationship between these and other molecular clouds, a control group of clouds was also observed. Excitation models for dense regions of all the clouds are constructed to evaluate molecular abundances in these regions. Those clouds that have embedded stars have lower molecular abundances than the clouds that do not. A cloud near the W28 supernova remnant also has low abundances. Molecular abundances are used to measure an important parameter, the electron density, which is not directly observable. In some clouds extensive deuterium fractionation is observed which confirms electron density measurements in those clouds. Where large deuterium fractionation is observed, the ionization rate in the cloud interior can also be measured. The electron density and ionization rate in the cloud near W28 are higher than in most clouds. The molecular abundances and electron densities are functions of the chemical and dynamical state of evolution of the cloud. Those clouds with lowest abundances are probably the youngest clouds. As low-abundance clouds, some clouds near supernova remnants may have been recently swept from the local interstellar material. Supernova remnants provide sites for star formation in ambient clouds by compressing them, and they sweep new clouds from more diffuse local matter

  3. Experimental study of linear and nonlinear regimes of density-driven instabilities induced by CO2 dissolution in water

    International Nuclear Information System (INIS)

    Outeda, R.; D'Onofrio, A.; El Hasi, C.; Zalts, A.

    2014-01-01

    Density driven instabilities produced by CO 2 (gas) dissolution in water containing a color indicator were studied in a Hele Shaw cell. The images were analyzed and instability patterns were characterized by mixing zone temporal evolution, dispersion curves, and the growth rate for different CO 2 pressures and different color indicator concentrations. The results obtained from an exhaustive analysis of experimental data show that this system has a different behaviour in the linear regime of the instabilities (when the growth rate has a linear dependence with time), from the nonlinear regime at longer times. At short times using a color indicator to see the evolution of the pattern, the images show that the effects of both the color indicator and CO 2 pressure are of the same order of magnitude: The growth rates are similar and the wave numbers are in the same range (0–30 cm −1 ) when the system is unstable. Although in the linear regime the dynamics is affected similarly by the presence of the indicator and CO 2 pressure, in the nonlinear regime, the influence of the latter is clearly more pronounced than the effects of the color indicator

  4. Drain Current Stress-Induced Instability in Amorphous InGaZnO Thin-Film Transistors with Different Active Layer Thicknesses

    Directory of Open Access Journals (Sweden)

    Dapeng Wang

    2018-04-01

    Full Text Available In this study, the initial electrical properties, positive gate bias stress (PBS, and drain current stress (DCS-induced instabilities of amorphous indium gallium zinc oxide (a-IGZO thin-film transistors (TFTs with various active layer thicknesses (TIGZO are investigated. As the TIGZO increased, the turn-on voltage (Von decreased, while the subthreshold swing slightly increased. Furthermore, the mobility of over 13 cm2·V−1·s−1 and the negligible hysteresis of ~0.5 V are obtained in all of the a-IGZO TFTs, regardless of the TIGZO. The PBS results exhibit that the Von shift is aggravated as the TIGZO decreases. In addition, the DCS-induced instability in the a-IGZO TFTs with various TIGZO values is revealed using current–voltage and capacitance–voltage (C–V measurements. An anomalous hump phenomenon is only observed in the off state of the gate-to-source (Cgs curve for all of the a-IGZO TFTs. This is due to the impact ionization that occurs near the drain side of the channel and the generated holes that flow towards the source side along the back-channel interface under the lateral electric field, which cause a lowered potential barrier near the source side. As the TIGZO value increased, the hump in the off state of the Cgs curve was gradually weakened.

  5. Drain Current Stress-Induced Instability in Amorphous InGaZnO Thin-Film Transistors with Different Active Layer Thicknesses.

    Science.gov (United States)

    Wang, Dapeng; Zhao, Wenjing; Li, Hua; Furuta, Mamoru

    2018-04-05

    In this study, the initial electrical properties, positive gate bias stress (PBS), and drain current stress (DCS)-induced instabilities of amorphous indium gallium zinc oxide (a-IGZO) thin-film transistors (TFTs) with various active layer thicknesses ( T IGZO ) are investigated. As the T IGZO increased, the turn-on voltage ( V on ) decreased, while the subthreshold swing slightly increased. Furthermore, the mobility of over 13 cm²·V −1 ·s −1 and the negligible hysteresis of ~0.5 V are obtained in all of the a-IGZO TFTs, regardless of the T IGZO . The PBS results exhibit that the V on shift is aggravated as the T IGZO decreases. In addition, the DCS-induced instability in the a-IGZO TFTs with various T IGZO values is revealed using current–voltage and capacitance–voltage ( C – V ) measurements. An anomalous hump phenomenon is only observed in the off state of the gate-to-source ( C gs ) curve for all of the a-IGZO TFTs. This is due to the impact ionization that occurs near the drain side of the channel and the generated holes that flow towards the source side along the back-channel interface under the lateral electric field, which cause a lowered potential barrier near the source side. As the T IGZO value increased, the hump in the off state of the C gs curve was gradually weakened.

  6. THREE-BEAM INSTABILITY IN THE LHC*

    CERN Document Server

    Burov, A

    2013-01-01

    In the LHC, a transverse instability is regularly observed at 4TeV right after the beta-squeeze, when the beams are separated by about their ten transverse rms sizes [1-3], and only one of the two beams is seen as oscillating. So far only a single hypothesis is consistent with all the observations and basic concepts, one about a third beam - an electron cloud, generated by the two proton beams in the high-beta areas of the interaction regions. The instability results from a combined action of the cloud nonlinear focusing and impedance.

  7. Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects

    Science.gov (United States)

    Morgan, William F.

    2003-01-01

    The goal of this review is to summarize the evidence for non-targeted and delayed effects of exposure to ionizing radiation in vivo. Currently, human health risks associated with radiation exposures are based primarily on the assumption that the detrimental effects of radiation occur in irradiated cells. Over the years a number of non-targeted effects of radiation exposure in vivo have been described that challenge this concept. These include radiation-induced genomic instability, bystander effects, clastogenic factors produced in plasma from irradiated individuals that can cause chromosomal damage when cultured with nonirradiated cells, and transgenerational effects of parental irradiation that can manifest in the progeny. These effects pose new challenges to evaluating the risk(s) associated with radiation exposure and understanding radiation-induced carcinogenesis.

  8. Electron cloud effects: codes and simulations at KEK

    International Nuclear Information System (INIS)

    Ohmi, K

    2013-01-01

    Electron cloud effects had been studied at KEK-Photon Factory since 1995. e-p instability had been studied in proton rings since 1965 in BINP, ISR and PSR. Study of electron cloud effects with the present style, which was based on numerical simulations, started at 1995 in positron storage rings. The instability observed in KEKPF gave a strong impact to B factories, KEKB and PEPII, which were final stage of their design in those days. History of cure for electron cloud instability overlapped the progress of luminosity performance in KEKB. The studies on electron cloud codes and simulations in KEK are presented. (author)

  9. Instability and noise-induced thermalization of Fermi–Pasta–Ulam recurrence in the nonlinear Schrödinger equation

    International Nuclear Information System (INIS)

    Wabnitz, Stefan; Wetzel, Benjamin

    2014-01-01

    We investigate the spontaneous growth of noise that accompanies the nonlinear evolution of seeded modulation instability into Fermi–Pasta–Ulam recurrence. Results from the Floquet linear stability analysis of periodic solutions of the three-wave truncation are compared with full numerical solutions of the nonlinear Schrödinger equation. The predicted initial stage of noise growth is in a good agreement with simulations, and is expected to provide further insight into the subsequent dynamics of the field evolution after recurrence breakup

  10. Instability and noise-induced thermalization of Fermi–Pasta–Ulam recurrence in the nonlinear Schrödinger equation

    Energy Technology Data Exchange (ETDEWEB)

    Wabnitz, Stefan, E-mail: stefan.wabnitz@unibs.it [Dipartimento di Ingegneria dell' Informazione, Università degli Studi di Brescia, via Branze 38, 25123 Brescia (Italy); Wetzel, Benjamin [INRS-EMT, 1650 Blvd. Lionel-Boulet, Varennes, Québec J3X 1S2 (Canada)

    2014-07-25

    We investigate the spontaneous growth of noise that accompanies the nonlinear evolution of seeded modulation instability into Fermi–Pasta–Ulam recurrence. Results from the Floquet linear stability analysis of periodic solutions of the three-wave truncation are compared with full numerical solutions of the nonlinear Schrödinger equation. The predicted initial stage of noise growth is in a good agreement with simulations, and is expected to provide further insight into the subsequent dynamics of the field evolution after recurrence breakup.

  11. DHX9 helicase is involved in preventing genomic instability induced by alternatively structured DNA in human cells.

    Science.gov (United States)

    Jain, Aklank; Bacolla, Albino; Del Mundo, Imee M; Zhao, Junhua; Wang, Guliang; Vasquez, Karen M

    2013-12-01

    Sequences that have the capacity to adopt alternative (i.e. non-B) DNA structures in the human genome have been implicated in stimulating genomic instability. Previously, we found that a naturally occurring intra-molecular triplex (H-DNA) caused genetic instability in mammals largely in the form of DNA double-strand breaks. Thus, it is of interest to determine the mechanism(s) involved in processing H-DNA. Recently, we demonstrated that human DHX9 helicase preferentially unwinds inter-molecular triplex DNA in vitro. Herein, we used a mutation-reporter system containing H-DNA to examine the relevance of DHX9 activity on naturally occurring H-DNA structures in human cells. We found that H-DNA significantly increased mutagenesis in small-interfering siRNA-treated, DHX9-depleted cells, affecting mostly deletions. Moreover, DHX9 associated with H-DNA in the context of supercoiled plasmids. To further investigate the role of DHX9 in the recognition/processing of H-DNA, we performed binding assays in vitro and chromatin immunoprecipitation assays in U2OS cells. DHX9 recognized H-DNA, as evidenced by its binding to the H-DNA structure and enrichment at the H-DNA region compared with a control region in human cells. These composite data implicate DHX9 in processing H-DNA structures in vivo and support its role in the overall maintenance of genomic stability at sites of alternatively structured DNA.

  12. Detection of induced male germline mutation: Correlations and comparisons between traditional germline mutation assays, transgenic rodent assays and expanded simple tandem repeat instability assays

    Energy Technology Data Exchange (ETDEWEB)

    Singer, Timothy M. [Mutagenesis Section, Environmental and Occupational Toxicology Division, Safe Environments Programme, 0803A, Health Canada, Ottawa, Ont., K1A 0K9 (Canada); Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ont., K1S 5B6 (Canada); Lambert, Iain B. [Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ont., K1S 5B6 (Canada); Williams, Andrew [Biostatistics and Epidemiology Division, Safe Environments Programme, 6604B, Health Canada, Ottawa, Ont., K1A 0K9 (Canada); Douglas, George R. [Mutagenesis Section, Environmental and Occupational Toxicology Division, Safe Environments Programme, 0803A, Health Canada, Ottawa, Ont., K1A 0K9 (Canada); Yauk, Carole L. [Mutagenesis Section, Environmental and Occupational Toxicology Division, Safe Environments Programme, 0803A, Health Canada, Ottawa, Ont., K1A 0K9 (Canada)]. E-mail: carole_yauk@hc-sc.gc.ca

    2006-06-25

    Several rodent assays are capable of monitoring germline mutation. These include traditional assays, such as the dominant lethal (DL) assay, the morphological specific locus (SL) test and the heritable translocation (HT) assay, and two assays that have been developed more recently-the expanded simple tandem repeat (ESTR) and transgenic rodent (TGR) mutation assays. In this paper, we have compiled the limited amount of experimental data that are currently available to make conclusions regarding the comparative ability of the more recently developed assays to detect germline mutations induced by chemical and radiological agents. The data suggest that ESTR and TGR assays are generally comparable with SL in detecting germline mutagenicity induced by alkylating agents and radiation, though TGR offered less sensitivity than ESTR in some cases. The DL and HT assays detect clastogenic events and are most susceptible to mutations arising in post-spermatogonial cells, and they may not provide the best comparisons with TGR and ESTR instability. The measurement of induced ESTR instability represents a relatively sensitive method of identifying agents causing germline mutation in rodents, and may also be useful for bio-monitoring exposed individuals in the human population. Any future use of the TGR and ESTR germline mutation assays in a regulatory testing context will entail more robust and extensive characterization of assay performance. This will require substantially more data, including experiments measuring multiple endpoints, a greatly expanded database of chemical agents and a focus on characterizing stage-specific activity of mutagens in these assays, preferably by sampling epididymal sperm exposed at defined pre-meiotic, meiotic and post-meiotic stages of development.

  13. Detection of induced male germline mutation: Correlations and comparisons between traditional germline mutation assays, transgenic rodent assays and expanded simple tandem repeat instability assays

    International Nuclear Information System (INIS)

    Singer, Timothy M.; Lambert, Iain B.; Williams, Andrew; Douglas, George R.; Yauk, Carole L.

    2006-01-01

    Several rodent assays are capable of monitoring germline mutation. These include traditional assays, such as the dominant lethal (DL) assay, the morphological specific locus (SL) test and the heritable translocation (HT) assay, and two assays that have been developed more recently-the expanded simple tandem repeat (ESTR) and transgenic rodent (TGR) mutation assays. In this paper, we have compiled the limited amount of experimental data that are currently available to make conclusions regarding the comparative ability of the more recently developed assays to detect germline mutations induced by chemical and radiological agents. The data suggest that ESTR and TGR assays are generally comparable with SL in detecting germline mutagenicity induced by alkylating agents and radiation, though TGR offered less sensitivity than ESTR in some cases. The DL and HT assays detect clastogenic events and are most susceptible to mutations arising in post-spermatogonial cells, and they may not provide the best comparisons with TGR and ESTR instability. The measurement of induced ESTR instability represents a relatively sensitive method of identifying agents causing germline mutation in rodents, and may also be useful for bio-monitoring exposed individuals in the human population. Any future use of the TGR and ESTR germline mutation assays in a regulatory testing context will entail more robust and extensive characterization of assay performance. This will require substantially more data, including experiments measuring multiple endpoints, a greatly expanded database of chemical agents and a focus on characterizing stage-specific activity of mutagens in these assays, preferably by sampling epididymal sperm exposed at defined pre-meiotic, meiotic and post-meiotic stages of development

  14. Foehn-induced effects on dust pollution, frontal clouds and solar radiation in the Dead Sea valley

    Science.gov (United States)

    Kishcha, Pavel; Starobinets, Boris; Alpert, Pinhas; Kaplan, Michael

    2017-04-01

    The significant drying up of the Dead Sea over the past 40 years has led to an increase in an exposed area contributing to local dust pollution. Measurements show that, sometimes, in the Dead Sea valley, dust pollution can reach extreme concentrations up to several thousands of micrograms per cubic meters. Our analysis of a meteorological situation shows that a foehn phenomenon can be a causal factor for the aforementioned extreme local dust concentration. This foehn phenomenon creates strong warm and dry winds, which are accompanied by air turbulence and temperature inversion. In our study, foehn-induced effects on dust pollution, frontal clouds and solar radiation were analyzed over the Judean Mountains ( 1000 m) and over the Dead Sea valley (-420 m), using high-resolution numerical simulations and in-situ observations at meteorological stations located across the mountain ridge. An extreme dust episode occurring on March 22, 2013, was analyzed, which was characterized by measured surface dust concentrations of up to 7000 µg m-3 in the Dead Sea valley. We simulated this foehn phenomenon with the 3-km resolution COSMO-ART model. Our analysis has shown that the foehn phenomenon could be observed even over the relatively low Judean Mountains. This analysis was based on various meteorological, pyranometer, radar, and aerosol measurements together with high-resolution model data. In the Dead Sea valley, the maximum aerosol optical depth (AOD) did not coincide with the maximum surface dust concentration. This lack of coincidence indicates difficulties in using satellite-based AOD for initializing dust concentration within numerical forecast systems over this region with complex terrain. In the western Dead Sea valley, strong foehn winds of over 20 m/s were accompanied by maximal air turbulence leading to maximal local dust emissions. Thus, the model showed that, by creating significant turbulence, the foehn phenomenon intensified the saltation (bombardment) mechanism

  15. Modeling of flashing-induced instabilities in the start-up phase of natural-circulation BWRs using the two-phase flow code FLOCAL

    Energy Technology Data Exchange (ETDEWEB)

    Manera, A. [Forschungszentrum Rossendorf e.V. (FZR), Institute of Safety Research, P.O.B. 510119, D-01324 Dresden (Germany) and Interfaculty Reactor Institute, Delft University of Technology, Mekelweg 15, 2629 JB Delft (Netherlands)]. E-mail: a.manera@fz-rossendorf.de; Rohde, U. [Forschungszentrum Rossendorf e.V. (FZR), Institute of Safety Research, P.O.B. 510119, D-01324 Dresden (Germany); Prasser, H.-M. [Forschungszentrum Rossendorf e.V. (FZR), Institute of Safety Research, P.O.B. 510119, D-01324 Dresden (Germany); Hagen, T.H.J.J. van der [Interfaculty Reactor Institute, Delft University of Technology, Mekelweg 15, 2629 JB Delft (Netherlands)

    2005-06-01

    This paper reports on the modeling and simulation of flashing-induced instabilities in natural-circulation systems, with special emphasis on natural-circulation boiling water reactors (BWRs). For the modeling the 4-equation two-phase model FLOCAL [Rohde, U., 1986. Ein teoretisches Modell fur Zweiphasen-stromungen in wassergekulthen Kernreaktoren und seine Anwendung zur Analyse des Naturumlaufs im Heizreaktor AST-500. Ph.D. dissertation, Akademie der Wissenschaften der DDR, Dresden], developed at the Forschungszentrum Rossendorf (FZR, Germany), has been used. The model allows for the liquid and vapor to be in thermal non-equilibrium and, via drift-flux models, to have different velocities. The phenomenology of the instability has been studied and the dominating physical effects have been determined. The results of the simulations have been compared qualitatively and quantitatively with experiments [Manera, A., van der Hagen, T.H.J.J., 2003. Stability of natural-circulation-cooled boiling water reactor during start up: experimental results. Nuc. Technol., 143] that have been carried out within the framework of a European project (NACUSP) on the CIRCUS facility. The facility, built at the Delft University of Technology in The Netherlands, is a water/steam 1:1 height-scaled loop of a typical natural-circulation-cooled BWR.

  16. Chemical complexity induced by efficient ice evaporation in the Barnard 5 molecular cloud

    Science.gov (United States)

    Taquet, V.; Wirström, E. S.; Charnley, S. B.; Faure, A.; López-Sepulcre, A.; Persson, C. M.

    2017-10-01

    Cold gas-phase water has recently been detected in a cold dark cloud, Barnard 5 located in the Perseus complex, by targeting methanol peaks as signposts for ice mantle evaporation. Observed morphology and abundances of methanol and water are consistent with a transient non-thermal evaporation process only affecting the outermost ice mantle layers, possibly triggering a more complex chemistry. Here we present the detection of the complex organic molecules (COMs) acetaldehyde (CH3CHO) and methyl formate (CH3OCHO), as well as formic acid (HCOOH) and ketene (CH2CO), and the tentative detection of di-methyl ether (CH3OCH3) towards the "methanol hotspot" of Barnard 5 located between two dense cores using the single dish OSO 20 m, IRAM 30 m, and NRO 45 m telescopes. The high energy cis-conformer of formic acid is detected, suggesting that formic acid is mostly formed at the surface of interstellar grains and then evaporated. The detection of multiple transitions for each species allows us to constrain their abundances through LTE and non-LTE methods. All the considered COMs show similar abundances between 1 and 10% relative to methanol depending on the assumed excitation temperature. The non-detection of glycolaldehyde, an isomer of methyl formate, with a [glycolaldehyde]/[methyl formate] abundance ratio lower than 6%, favours gas phase formation pathways triggered by methanol evaporation. According to their excitation temperatures derived in massive hot cores, formic acid, ketene, and acetaldehyde have been designated as "lukewarm" COMs whereas methyl formate and di-methyl ether were defined as "warm" species. Comparison with previous observations of other types of sources confirms that lukewarm and warm COMs show similar abundances in low-density cold gas whereas the warm COMs tend to be more abundant than the lukewarm species in warm protostellar cores. This abundance evolution suggests either that warm COMs are indeed mostly formed in protostellar environments and

  17. Role of ZrO2 incorporation in the suppression of negative bias illumination-induced instability in Zn-Sn-O thin film transistors

    International Nuclear Information System (INIS)

    Yang, Bong Seob; Oh, Seungha; Lee, Ung Soo; Kim, Yoon Jang; Oh, Myeong Sook; Hwang, Cheol Seong; Kim, Hyeong Joon; Huh, Myung Soo; Jeong, Jae Kyeong

    2011-01-01

    Thin film transistors (TFTs) with In and Ga-free multicomponent Zn-Sn-Zr-O (ZTZO) channel layers were fabricated using the cosputtering approach. The incorporation of ZrO 2 into the Zn-Sn-O (ZTO) films increased the contact resistance, which led to the degradation of the transport properties. In contrast, the threshold voltage shift under negative bias illumination stress (NBIS) was largely improved from -12.5 V (ZTO device) to -4.2 V (ZTZO device). This improvement was attributed to the reduction in the oxygen vacancy defects in the ZTZO film, suggesting that the photoinduced transition from V O to V O 2+ was responsible for the NBIS-induced instability.

  18. Foehn-induced effects on local dust pollution, frontal clouds and solar radiation in the Dead Sea valley

    Science.gov (United States)

    Kishcha, Pavel; Starobinets, Boris; Savir, Amit; Alpert, Pinhas; Kaplan, Michael

    2018-06-01

    Despite the long history of investigation of foehn phenomena, there are few studies of the influence of foehn winds on air pollution and none in the Dead Sea valley. For the first time the foehn phenomenon and its effects on local dust pollution, frontal cloudiness and surface solar radiation were analyzed in the Dead Sea valley, as it occurred on 22 March 2013. This was carried out using both numerical simulations and observations. The foehn winds intensified local dust emissions, while the foehn-induced temperature inversion trapped dust particles beneath this inversion. These two factors caused extreme surface dust concentration in the western Dead Sea valley. The dust pollution was transported by west winds eastward, to the central Dead Sea valley, where the speed of these winds sharply decreased. The transported dust was captured by the ascending airflow contributing to the maximum aerosol optical depth (AOD) over the central Dead Sea valley. On the day under study, the maximum surface dust concentration did not coincide with the maximum AOD: this being one of the specific effects of the foehn phenomenon on dust pollution in the Dead Sea valley. Radar data showed a passage of frontal cloudiness through the area of the Dead Sea valley leading to a sharp drop in noon solar radiation. The descending airflow over the downwind side of the Judean Mountains led to the formation of a cloud-free band followed by only the partial recovery of solar radiation because of the extreme dust pollution caused by foehn winds.

  19. The photoevaporation of interstellar clouds

    International Nuclear Information System (INIS)

    Bertoldi, F.

    1989-01-01

    The dynamics of the photoevaporation of interstellar clouds and its consequences for the structure and evolution of H II regions are studied. An approximate analytical solution for the evolution of photoevaporating clouds is derived under the realistic assumption of axisymmetry. The effects of magnetic fields are taken into account in an approximate way. The evolution of a neutral cloud subjected to the ionizing radiation of an OB star has two distinct stages. When a cloud is first exposed to the radiation, the increase in pressure due to the ionization at the surface of the cloud leads to a radiation-driven implosion: an ionization front drives a shock into the cloud, ionizes part of it and compresses the remaining into a dense globule. The initial implosion is followed by an equilibrium cometary stage, in which the cloud maintains a semistationary comet-shaped configuration; it slowly evaporates while accelerating away from the ionizing star until the cloud has been completely ionized, reaches the edge of the H II region, or dies. Expressions are derived for the cloud mass-loss rate and acceleration. To investigate the effect of the cloud photoevaporation on the structure of H II regions, the evolution of an ensemble of clouds of a given mass distribution is studied. It is shown that the compressive effect of the ionizing radiation can induce star formation in clouds that were initially gravitationally stable, both for thermally and magnetically supported clouds

  20. Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells

    Science.gov (United States)

    Yoneshima, Yasuto; Abolhassani, Nona; Iyama, Teruaki; Sakumi, Kunihiko; Shiomi, Naoko; Mori, Masahiko; Shiomi, Tadahiro; Noda, Tetsuo; Tsuchimoto, Daisuke; Nakabeppu, Yusaku

    2016-01-01

    Deoxyinosine (dI) occurs in DNA either by oxidative deamination of a previously incorporated deoxyadenosine residue or by misincorporation of deoxyinosine triphosphate (dITP) from the nucleotide pool during replication. To exclude dITP from the pool, mammals possess specific hydrolysing enzymes, such as inosine triphosphatase (ITPA). Previous studies have shown that deficiency in ITPA results in cell growth suppression and DNA instability. To explore the mechanisms of these phenotypes, we analysed ITPA-deficient human and mouse cells. We found that both growth suppression and accumulation of single-strand breaks in nuclear DNA of ITPA-deficient cells depended on MLH1/PMS2. The cell growth suppression of ITPA-deficient cells also depended on p53, but not on MPG, ENDOV or MSH2. ITPA deficiency significantly increased the levels of p53 protein and p21 mRNA/protein, a well-known target of p53, in an MLH1-dependent manner. Furthermore, MLH1 may also contribute to cell growth arrest by increasing the basal level of p53 activity. PMID:27618981

  1. Investigation of the gate-bias induced instability for InGaZnO TFTs under dark and light illumination

    International Nuclear Information System (INIS)

    Chen, T.C.; Chang, T.C.; Hsieh, T.Y.; Tsai, C.T.; Chen, S.C.; Lin, C.S.; Jian, F.Y.; Tsai, M.Y.

    2011-01-01

    Mechanism of the instability for indium–gallium–zinc oxide thin film transistors caused by gate-bias stress performed in the dark and light illumination was investigated in this paper. The parallel V t shift with no degradation of subthreshold swing (S.S) and the fine fitting to the stretched-exponential equation indicate that charge trapping model dominates the degradation behavior under positive gate-bias stress. In addition, the significant gate-bias dependence of V t shift demonstrates that electron trapping effect easily occurs under large gate-bias since the average effective energy barrier of electron injection decreases with increasing gate bias. Moreover, the noticeable decrease of threshold voltage (V t ) shift under illuminated positive gate-bias stress and the accelerated recovery rate in the light indicate that the charge detrapping mechanism occurs under light illumination. Finally, the apparent negative V t shift under illuminated negative gate-bias stress was investigated in this paper. The average effectively energy barrier of electron and hole injection were extracted to clarify that the serious V t degradation behavior comparing with positive gate-bias stress was attributed to the lower energy barrier for hole injection.

  2. Electric-field induced surface instabilities of soft dielectrics and their effects on optical transmittance and scattering

    Science.gov (United States)

    Shian, Samuel; Kjeer, Peter; Clarke, David R.

    2018-03-01

    When a voltage is applied to a percolative, mechanically compliant mat of carbon nanotubes (CNTs) on a smooth elastomer bilayer attached to an ITO coated glass substrate, the in-line optical transmittance decreases with increasing voltage. Two regimes of behavior have been identified based on optical scattering, bright field optical microscopy, and confocal optical microscopy. In the low field regime, the electric field produces a spatially inhomogeneous surface deformation of the elastomer that causes local variations in optical refraction and modulates the light transmittance. The spatial variation is associated with the distribution of the CNTs over the surface. At higher fields, above a threshold voltage, an array of pits in the surface form by a nucleation and growth mechanism and these also scatter light. The formation of pits, and creases, in the thickness of the elastomer, is due to a previously identified electro-mechanical surface instability. When the applied voltage is decreased from its maximum, the transmittance returns to its original value although there is a transmittance hysteresis and a complicated time response. When the applied voltage exceeds the threshold voltage, there can be remnant optical contrast associated with creasing of the elastomer and the recovery time appears to be dependent on local jamming of CNTs in areas where the pits formed. A potential application of this work as an electrically tunable privacy window or camouflaging devices is demonstrated.

  3. Edge instabilities of topological superconductors

    Energy Technology Data Exchange (ETDEWEB)

    Hofmann, Johannes S. [Institut fuer Theoretische Physik und Astrophysik, Universitaet Wuerzburg (Germany); Max-Planck-Institut fuer Festkoerperforschung, Stuttgart (Germany); Assaad, Fakher F. [Institut fuer Theoretische Physik und Astrophysik, Universitaet Wuerzburg (Germany); Schnyder, Andreas P. [Max-Planck-Institut fuer Festkoerperforschung, Stuttgart (Germany)

    2016-07-01

    Nodal topological superconductors display zero-energy Majorana flat bands at generic edges. The flatness of these edge bands, which is protected by time-reversal and translation symmetry, gives rise to an extensive ground state degeneracy and a diverging density of states. Therefore, even arbitrarily weak interactions lead to an instability of the flat-band edge states towards time-reversal and translation-symmetry broken phases, which lift the ground-state degeneracy. Here, we employ Monte Carlo simulations combined with mean-field considerations to examine the instabilities of the flat-band edge states of d{sub xy}-wave superconductors. We find that attractive interactions induce a complex s-wave pairing instability together with a density wave instability. Repulsive interactions, on the other hand, lead to ferromagnetism mixed with spin-triplet pairing at the edge. We discuss the implications of our findings for experiments on cuprate high-temperature superconductors.

  4. Niacin deficiency delays DNA excision repair and increases spontaneous and nitrosourea-induced chromosomal instability in rat bone marrow.

    Science.gov (United States)

    Kostecki, Lisa M; Thomas, Megan; Linford, Geordie; Lizotte, Matthew; Toxopeus, Lori; Bartleman, Anne-Pascale; Kirkland, James B

    2007-12-01

    We have shown that niacin deficiency impairs poly(ADP-ribose) formation and enhances sister chromatid exchanges and micronuclei formation in rat bone marrow. We designed the current study to investigate the effects of niacin deficiency on the kinetics of DNA repair following ethylation, and the accumulation of double strand breaks, micronuclei (MN) and chromosomal aberrations (CA). Weanling male Long-Evans rats were fed niacin deficient (ND), or pair fed (PF) control diets for 3 weeks. We examined repair kinetics by comet assay in the 36h following a single dose of ethylnitrosourea (ENU) (30mg/kg bw). There was no effect of ND on mean tail moment (MTM) before ENU treatment, or on the development of strand breaks between 0 and 8h after ENU. Repair kinetics between 12 and 30h were significantly delayed by ND, with a doubling of area under the MTM curve during this period. O(6)-ethylation of guanine peaked by 1.5h, was largely repaired by 15h, and was also delayed in bone marrow cells from ND rats. ND significantly enhanced double strand break accumulation at 24h after ENU. ND alone increased chromosome and chromatid breaks (four- and two-fold). ND alone caused a large increase in MN, and this was amplified by ENU treatment. While repair kinetics suggest that ND may be acting by creating catalytically inactive PARP molecules with a dominant-negative effect on repair processes, the effect of ND alone on O(6)-ethylation, MN and CA, in the absence of altered comet results, suggests additional mechanisms are also leading to chromosomal instability. These data support the idea that the bone marrow cells of niacin deficient cancer patients may be more sensitive to the side effects of genotoxic chemotherapy, resulting in acute bone marrow suppression and chronic development of secondary leukemias.

  5. Radiation-induced genomic instability and bystander effects: inter-related inflammatory-type non-targeted effects of exposure to ionizing radiation

    Energy Technology Data Exchange (ETDEWEB)

    Wright, E.G. (Molecular and Cellular Pathology Laboratories, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, Dundee, Scotland (United Kingdom))

    2008-12-15

    The dogma that genetic alterations are restricted to directly irradiated cells has been challenged by observations in which effects of ionizing radiation, characteristically associated with the consequences of energy deposition in the cell nucleus, arise in non-irradiated cells. These, so called, untargeted effects are demonstrated in cells that are the descendants of irradiated cells (radiation-induced genomic instability) or in cells that have communicated with neighbouring irradiated cells (radiation-induced bystander effects). There are also reports of long-range signals in vivo, known as clastogenic factors, with the capacity to induce damage in unirradiated cells. Clastogenic factors may be related to the inflammatory responses that have been implicated in some of the pathological consequences of radiation exposures. The phenotypic expression of untargeted effects reflects a balance between the type of signals produced and the responses of cell populations to such signals, both of which may be significantly influenced by cell type and genotype. There is accumulating evidence that untargeted effects in vitro involve inter-cellular signalling, production of cytokines and free radical generation. These are also features of inflammatory responses in vivo that are known to have the potential for both bystander-mediated and persisting damage as well as for conferring a predisposition to malignancy. At present it is far from clear how untargeted effects contribute to overall cellular radiation responses and in vivo consequences but it is possible that the various untargeted effects may reflect inter-related aspects of a non-specific inflammatory-type response to radiation-induced stress and injury and be involved in a variety of the pathological consequences of radiation exposures. (orig.)

  6. Radiation-induced genomic instability and bystander effects: inter-related inflammatory-type non-targeted effects of exposure to ionizing radiation

    International Nuclear Information System (INIS)

    Wright, E.G.

    2008-01-01

    The dogma that genetic alterations are restricted to directly irradiated cells has been challenged by observations in which effects of ionizing radiation, characteristically associated with the consequences of energy deposition in the cell nucleus, arise in non-irradiated cells. These, so called, untargeted effects are demonstrated in cells that are the descendants of irradiated cells (radiation-induced genomic instability) or in cells that have communicated with neighbouring irradiated cells (radiation-induced bystander effects). There are also reports of long-range signals in vivo, known as clastogenic factors, with the capacity to induce damage in unirradiated cells. Clastogenic factors may be related to the inflammatory responses that have been implicated in some of the pathological consequences of radiation exposures. The phenotypic expression of untargeted effects reflects a balance between the type of signals produced and the responses of cell populations to such signals, both of which may be significantly influenced by cell type and genotype. There is accumulating evidence that untargeted effects in vitro involve inter-cellular signalling, production of cytokines and free radical generation. These are also features of inflammatory responses in vivo that are known to have the potential for both bystander-mediated and persisting damage as well as for conferring a predisposition to malignancy. At present it is far from clear how untargeted effects contribute to overall cellular radiation responses and in vivo consequences but it is possible that the various untargeted effects may reflect inter-related aspects of a non-specific inflammatory-type response to radiation-induced stress and injury and be involved in a variety of the pathological consequences of radiation exposures. (orig.)

  7. Nonlinear propagation of a spatially incoherent laser beam: self-induced smoothing and reduction of scattering instabilities

    International Nuclear Information System (INIS)

    Maximov, A.V.; Ourdev, I.G.; Rozmus, W.; Capjack, C.E.; Mounaix, Ph.; Huller, S.; Pesme, D.; Tikhonchuk, V.T.; Divol, L.

    2000-01-01

    It is shown that plasma-induced angular spreading and spectral broadening of a spatially incoherent laser beam correspond to increased spatial and temporal incoherence of the laser light. The spatial incoherence is characterized by an effective beam f-number, decreasing in space along the direction of light propagation. Plasma-induced beam smoothing can influence laser-plasma interaction physics. In particular, decreasing the correlation time of the propagating laser light may dramatically reduce the levels of backward stimulated Brillouin and Raman scattering inside the plasma. Also, the decrease of the laser beam effective f-number reduces the reflectivity of backward stimulated Brillouin scattering. (authors)

  8. Cloud Governance

    DEFF Research Database (Denmark)

    Berthing, Hans Henrik

    Denne præsentation beskriver fordele og værdier ved anvendelse af Cloud Computing. Endvidere inddrager resultater fra en række internationale analyser fra ISACA om Cloud Computing.......Denne præsentation beskriver fordele og værdier ved anvendelse af Cloud Computing. Endvidere inddrager resultater fra en række internationale analyser fra ISACA om Cloud Computing....

  9. Genomic instability and radiation effects

    International Nuclear Information System (INIS)

    Christian Streffer

    2007-01-01

    Complete text of publication follows. Cancer, genetic mutations and developmental abnormalities are apparently associated with an increased genomic instability. Such phenomena have been frequently shown in human cancer cells in vitro and in situ. It is also well-known that individuals with a genetic predisposition for cancer proneness, such as ataxia telangiectesia, Fanconi anaemia etc. demonstrate a general high genomic instability e.g. in peripheral lymphocytes before a cancer has developed. Analogous data have been found in mice which develop a specific congenital malformation which has a genetic background. Under these aspects it is of high interest that ionising radiation can increase the genomic instability of mammalian cells after exposures in vitro an in vivo. This phenomenon is expressed 20 to 40 cell cycles after the exposure e.g. by de novo chromosomal aberrations. Such effects have been observed with high and low LET radiation, high LET radiation is more efficient. With low LET radiation a good dose response is observed in the dose range 0.2 to 2.0 Gy, Recently it has been reported that senescence and genomic instability was induced in human fibroblasts after 1 mGy carbon ions (1 in 18 cells are hit), apparently bystander effects also occurred under these conditions. The instability has been shown with DNA damage, chromosomal aberrations, gene mutation and cell death. It is also transferred to the next generation of mice with respect to gene mutations, chromosomal aberrations and congenital malformations. Several mechanisms have been discussed. The involvement of telomeres has gained interest. Genomic instability seems to be induced by a general lesion to the whole genome. The transmission of one chromosome from an irradiated cell to an non-irradiated cell leads to genomic instability in the untreated cells. Genomic instability increases mutation rates in the affected cells in general. As radiation late effects (cancer, gene mutations and congenital

  10. Electron-cloud build-up in hadron machines

    International Nuclear Information System (INIS)

    Furman, M.A.

    2004-01-01

    The first observations of electron-proton coupling effect for coasting beams and for long-bunch beams were made at the earliest proton storage rings at the Budker Institute of Nuclear Physics (BINP) in the mid-60's [1]. The effect was mainly a form of the two-stream instability. This phenomenon reappeared at the CERN ISR in the early 70's, where it was accompanied by an intense vacuum pressure rise. When the ISR was operated in bunched-beam mode while testing aluminum vacuum chambers, a resonant effect was observed in which the electron traversal time across the chamber was comparable to the bunch spacing [2]. This effect (''beam-induced multipacting''), being resonant in nature, is a dramatic manifestation of an electron cloud sharing the vacuum chamber with a positively-charged beam. An electron-cloud-induced instability has been observed since the mid-80's at the PSR (LANL) [3]; in this case, there is a strong transverse instability accompanied by fast beam losses when the beam current exceeds a certain threshold. The effect was observed for the first time for a positron beam in the early 90's at the Photon Factory (PF) at KEK, where the most prominent manifestation was a coupled-bunch instability that was absent when the machine was operated with an electron beam under otherwise identical conditions [4]. Since then, with the advent of ever more intense positron and hadron beams, and the development and deployment of specialized electron detectors [5-9], the effect has been observed directly or indirectly, and sometimes studied systematically, at most lepton and hadron machines when operated with sufficiently intense beams. The effect is expected in various forms and to various degrees in accelerators under design or construction. The electron-cloud effect (ECE) has been the subject of various meetings [10-15]. Two excellent reviews, covering the phenomenology, measurements, simulations and historical development, have been recently given by Frank Zimmermann [16

  11. Radiation-induced colon cancer with high frequency microsatellite instability (MSI-H), report of a case

    Energy Technology Data Exchange (ETDEWEB)

    Arai, Masami; Ueno, Masashi; Koizumi, Koichi [Japanese Foundation for Cancer Research, Tokyo (Japan). Hospital] [and others

    2002-07-01

    We report a 67-year-old female with radiation-induced colon cancer which developed 23 years after radiation therapy for cancer of the endometrium. She was strongly suspected to be a case of hereditary nonpolyposis colorectal cancer (HNPCC) due to her clinical manifestations, i.e. metachronous multiple cancer developed in the endometrium and colon. MSI test and immunohistochemistry for mismatch repair (MMR) proteins revealed that MSI was highly positive and expression of hMSH2 was lost in the colon cancers. Further, on examining the genetic change, the point mutation, ACG{yields}ATG, responsible for amino acid change, was detected in codon8 (exon1) of the hMSH2 gene. The change, however, could be a polymorphism of this gene and further analyses were necessitated to confirm the genetic background for HNPCC. Interestingly, three cancers with adenoma were located in the mucosa of radiation colitis, in which several atypical glands were also found. This is the only case of radiation-induced colorectal cancer with MSI-H in our hospital. Because of our previous studies, we believe that the genetic pathway in carcinogenesis of the radiation-induced colon cancer is different from that of HNPCC, despite their having several kinds of clinical and pathological features in common. (author)

  12. Radiation-induced colon cancer with high frequency microsatellite instability (MSI-H), report of a case

    International Nuclear Information System (INIS)

    Arai, Masami; Ueno, Masashi; Koizumi, Koichi

    2002-01-01

    We report a 67-year-old female with radiation-induced colon cancer which developed 23 years after radiation therapy for cancer of the endometrium. She was strongly suspected to be a case of hereditary nonpolyposis colorectal cancer (HNPCC) due to her clinical manifestations, i.e. metachronous multiple cancer developed in the endometrium and colon. MSI test and immunohistochemistry for mismatch repair (MMR) proteins revealed that MSI was highly positive and expression of hMSH2 was lost in the colon cancers. Further, on examining the genetic change, the point mutation, ACG→ATG, responsible for amino acid change, was detected in codon8 (exon1) of the hMSH2 gene. The change, however, could be a polymorphism of this gene and further analyses were necessitated to confirm the genetic background for HNPCC. Interestingly, three cancers with adenoma were located in the mucosa of radiation colitis, in which several atypical glands were also found. This is the only case of radiation-induced colorectal cancer with MSI-H in our hospital. Because of our previous studies, we believe that the genetic pathway in carcinogenesis of the radiation-induced colon cancer is different from that of HNPCC, despite their having several kinds of clinical and pathological features in common. (author)

  13. Core/Shell Microstructure Induced Synergistic Effect for Efficient Water-Droplet Formation and Cloud-Seeding Application.

    Science.gov (United States)

    Tai, Yanlong; Liang, Haoran; Zaki, Abdelali; El Hadri, Nabil; Abshaev, Ali M; Huchunaev, Buzgigit M; Griffiths, Steve; Jouiad, Mustapha; Zou, Linda

    2017-12-26

    Cloud-seeding materials as a promising water-augmentation technology have drawn more attention recently. We designed and synthesized a type of core/shell NaCl/TiO 2 (CSNT) particle with controlled particle size, which successfully adsorbed more water vapor (∼295 times at low relative humidity, 20% RH) than that of pure NaCl, deliquesced at a lower environmental RH of 62-66% than the hygroscopic point (h g.p ., 75% RH) of NaCl, and formed larger water droplets ∼6-10 times its original measured size area, whereas the pure NaCl still remained as a crystal at the same conditions. The enhanced performance was attributed to the synergistic effect of the hydrophilic TiO 2 shell and hygroscopic NaCl core microstructure, which attracted a large amount of water vapor and turned it into a liquid faster. Moreover, the critical particle size of the CSNT particles (0.4-10 μm) as cloud-seeding materials was predicted via the classical Kelvin equation based on their surface hydrophilicity. Finally, the benefits of CSNT particles for cloud-seeding applications were determined visually through in situ observation under an environmental scanning electron microscope on the microscale and cloud chamber experiments on the macroscale, respectively. These excellent and consistent performances positively confirmed that CSNT particles could be promising cloud-seeding materials.

  14. Aeroelastic instability problems for wind turbines

    DEFF Research Database (Denmark)

    Hansen, Morten Hartvig

    2007-01-01

    This paper deals with the aeroelostic instabilities that have occurred and may still occur for modem commercial wind turbines: stall-induced vibrations for stall-turbines, and classical flutter for pitch-regulated turbines. A review of previous works is combined with derivations of analytical...... stiffness and chordwise position of the center of gravity along the blades are the main parameters for flutter. These instability characteristics are exemplified by aeroelastic stability analyses of different wind turbines. The review of each aeroelastic instability ends with a list of current research...... issues that represent unsolved aeroelostic instability problems for wind turbines. Copyright (c) 2007 John Wiley & Sons, Ltd....

  15. Mode-locking via dissipative Faraday instability.

    Science.gov (United States)

    Tarasov, Nikita; Perego, Auro M; Churkin, Dmitry V; Staliunas, Kestutis; Turitsyn, Sergei K

    2016-08-09

    Emergence of coherent structures and patterns at the nonlinear stage of modulation instability of a uniform state is an inherent feature of many biological, physical and engineering systems. There are several well-studied classical modulation instabilities, such as Benjamin-Feir, Turing and Faraday instability, which play a critical role in the self-organization of energy and matter in non-equilibrium physical, chemical and biological systems. Here we experimentally demonstrate the dissipative Faraday instability induced by spatially periodic zig-zag modulation of a dissipative parameter of the system-spectrally dependent losses-achieving generation of temporal patterns and high-harmonic mode-locking in a fibre laser. We demonstrate features of this instability that distinguish it from both the Benjamin-Feir and the purely dispersive Faraday instability. Our results open the possibilities for new designs of mode-locked lasers and can be extended to other fields of physics and engineering.

  16. Fungal-induced cell cycle impairment, chromosome instability and apoptosis via differential activation of NF-κB.

    Directory of Open Access Journals (Sweden)

    Mariem Ben-Abdallah

    Full Text Available Microbial pathogens have developed efficient strategies to compromise host immune responses. Cryptococcus neoformans is a facultative intracellular pathogen, recognised as the most common cause of systemic fungal infections leading to severe meningoencephalitis, mainly in immunocompromised patients. This yeast is characterized by a polysaccharide capsule, which inhibits its phagocytosis. Whereas phagocytosis escape and macrophage intracellular survival have been intensively studied, extracellular survival of this yeast and restraint of host innate immune response are still poorly understood. In this study, we have investigated whether C. neoformans affected macrophage cell viability and whether NF-κB (nuclear factor-κB, a key regulator of cell growth, apoptosis and inflammation, was involved. Using wild-type (WT as well as mutant strains of C. neoformans for the pathogen side, and WT and mutant cell lines with altered NF-κB activity or signalling as well as primary macrophages for the host side, we show that C. neoformans manipulated NF-κB-mediated signalling in a unique way to regulate macrophage cell fate and viability. On the one hand, serotype A strains reduced macrophage proliferation in a capsule-independent fashion. This growth decrease, which required a critical dosage of NF-κB activity, was caused by cell cycle disruption and aneuploidy, relying on fungal-induced modification of expression of several cell cycle checkpoint regulators in S and G2/M phases. On the other hand, C. neoformans infection induced macrophage apoptosis in a capsule-dependent manner with a differential requirement of the classical and alternative NF-κB signalling pathways, the latter one being essential. Together, these findings shed new light on fungal strategies to subvert host response through uncoupling of NF-κB activity in pathogen-controlled apoptosis and impairment of cell cycle progression. They also provide the first demonstration of induction of

  17. Electron beam instabilities in gyrotron beam tunnels

    International Nuclear Information System (INIS)

    Pedrozzi, M.; Alberti, S.; Hogge, J.P.; Tran, M.Q.; Tran, T.M.

    1997-10-01

    Electron beam instabilities occurring in a gyrotron electron beam can induce an energy spread which might significantly deteriorate the gyrotron efficiency. Three types of instabilities are considered to explain the important discrepancy found between the theoretical and experimental efficiency in the case of quasi-optical gyrotrons (QOG): the electron cyclotron maser instability, the Bernstein instability and the Langmuir instability. The low magnetic field gradient in drift tubes of QOG makes that the electron cyclotron maser instability can develop in the drift tube at very low electron beam currents. Experimental measurements show that with a proper choice of absorbing structures in the beam tunnel, this instability can be suppressed. At high beam currents, the electrostatic Bernstein instability can induce a significant energy spread at the entrance of the interaction region. The induced energy spread scales approximately linearly with the electron beam density and for QOG one observes that the beam density is significantly higher than the beam density of an equivalent cylindrical cavity gyrotron. (author) figs., tabs., refs

  18. Scintillator based detector for fast-ion losses induced by magnetohydrodynamic instabilities in the ASDEX upgrade tokamak.

    Science.gov (United States)

    García-Muñoz, M; Fahrbach, H-U; Zohm, H

    2009-05-01

    A scintillator based detector for fast-ion losses has been designed and installed on the ASDEX upgrade (AUG) tokamak [A. Herrmann and O. Gruber, Fusion Sci. Technol. 44, 569 (2003)]. The detector resolves in time the energy and pitch angle of fast-ion losses induced by magnetohydrodynamics (MHD) fluctuations. The use of a novel scintillator material with a very short decay time and high quantum efficiency allows to identify the MHD fluctuations responsible for the ion losses through Fourier analysis. A Faraday cup (secondary scintillator plate) has been embedded behind the scintillator plate for an absolute calibration of the detector. The detector is mounted on a manipulator to vary its radial position with respect to the plasma. A thermocouple on the inner side of the graphite protection enables the safety search for the most adequate radial position. To align the scintillator light pattern with the light detectors a system composed by a lens and a vacuum-compatible halogen lamp has been allocated within the detector head. In this paper, the design of the scintillator probe, as well as the new technique used to analyze the data through spectrograms will be described. A last section is devoted to discuss the diagnosis prospects of this method for ITER [M. Shimada et al., Nucl. Fusion 47, S1 (2007)].

  19. Waves on the surface of the Orion molecular cloud.

    Science.gov (United States)

    Berné, Olivier; Marcelino, Núria; Cernicharo, José

    2010-08-19

    Massive stars influence their parental molecular cloud, and it has long been suspected that the development of hydrodynamical instabilities can compress or fragment the cloud. Identifying such instabilities has proved difficult. It has been suggested that elongated structures (such as the 'pillars of creation') and other shapes arise because of instabilities, but alternative explanations are available. One key signature of an instability is a wave-like structure in the gas, which has hitherto not been seen. Here we report the presence of 'waves' at the surface of the Orion molecular cloud near where massive stars are forming. The waves seem to be a Kelvin-Helmholtz instability that arises during the expansion of the nebula as gas heated and ionized by massive stars is blown over pre-existing molecular gas.

  20. Cloud Computing

    CERN Document Server

    Antonopoulos, Nick

    2010-01-01

    Cloud computing has recently emerged as a subject of substantial industrial and academic interest, though its meaning and scope is hotly debated. For some researchers, clouds are a natural evolution towards the full commercialisation of grid systems, while others dismiss the term as a mere re-branding of existing pay-per-use technologies. From either perspective, 'cloud' is now the label of choice for accountable pay-per-use access to third party applications and computational resources on a massive scale. Clouds support patterns of less predictable resource use for applications and services a

  1. Cavitation instabilities in hydraulic machines

    International Nuclear Information System (INIS)

    Tsujimoto, Y

    2013-01-01

    Cavitation instabilities in hydraulic machines, hydro turbines and turbopump inducers, are reviewed focusing on the cause of instabilities. One-dimensional model of hydro turbine system shows that the overload surge is caused by the diffuser effect of the draft tube. Experiments show that this effect also causes the surge mode oscillations at part load. One dimensional model of a cavitating turbopump inducer shows that the mass flow gain factor, representing the cavity volume increase caused by the incidence angle increase is the cause of cavitation surge and rotating cavitation. Two dimensional model of a cavitating turbopump inducer shows that various modes of cavitation instabilities start to occur when the cavity length becomes about 65% of the blade spacing. This is caused by the interaction of the local flow near the cavity trailing edge with the leading edge of the next blade. It was shown by a 3D CFD that this is true also for real cases with tip cavitation. In all cases, it was shown that cavitation instabilities are caused by the fundamental characteristics of cavities that the cavity volume increases with the decrease of ambient pressure or the increase of the incidence angle

  2. Electron-cloud effects in high-luminosity colliders

    Energy Technology Data Exchange (ETDEWEB)

    Zimmermann, F.

    1998-01-01

    Electron-cloud instabilities are expected to be important in most high-luminosity double-ring colliders. In this report, the author describes a few parameter regimes and some critical parameter dependences of this type of instability, and illustrate these with simulation results for the PEP-II and KEK B factories, the LHC, the VLHC, and DAPHNE. In addition, the author studies the possibility and the potential impact of an electron cloud in the interaction region.

  3. Anisotropic gravitational instability

    International Nuclear Information System (INIS)

    Polyachenko, V.L.; Fridman, A.M.

    1988-01-01

    Exact solutions of stability problems are obtained for two anisotropic gravitational systems of different geometries - a layer of finite thickness at rest and a rotating cylinder of finite radius. It is shown that the anisotropic gravitational instability which develops in both cases is of Jeans type. However, in contrast to the classical aperiodic Jeans instability, this instability is oscillatory. The physics of the anisotropic gravitational instability is investigated. It is shown that in a gravitating layer this instability is due, in particular, to excitation of previously unknown interchange-Jeans modes. In the cylinder, the oscillatory Jeans instability is associated with excitation of a rotational branch, this also being responsible for the beam gravitational instability. This is the reason why this instability and the anisotropic gravitational instability have so much in common

  4. Fast Molecular Cloud Destruction Requires Fast Cloud Formation

    Energy Technology Data Exchange (ETDEWEB)

    Mac Low, Mordecai-Mark [American Museum of Natural History, 79th Street at Central Park West, New York, NY 10024 (United States); Burkert, Andreas [Universitäts Sternwarte München, Ludwigs-Maximilian-Universität, D-81679 München (Germany); Ibáñez-Mejía, Juan C., E-mail: mordecai@amnh.org, E-mail: burkert@usm.lmu.de, E-mail: ibanez@ph1.uni-koeln.de [Max-Planck-Institut für Extraterrestrische Physik, D-85748 Garching bei München (Germany)

    2017-09-20

    A large fraction of the gas in the Galaxy is cold, dense, and molecular. If all this gas collapsed under the influence of gravity and formed stars in a local free-fall time, the star formation rate in the Galaxy would exceed that observed by more than an order of magnitude. Other star-forming galaxies behave similarly. Yet, observations and simulations both suggest that the molecular gas is indeed gravitationally collapsing, albeit hierarchically. Prompt stellar feedback offers a potential solution to the low observed star formation rate if it quickly disrupts star-forming clouds during gravitational collapse. However, this requires that molecular clouds must be short-lived objects, raising the question of how so much gas can be observed in the molecular phase. This can occur only if molecular clouds form as quickly as they are destroyed, maintaining a global equilibrium fraction of dense gas. We therefore examine cloud formation timescales. We first demonstrate that supernova and superbubble sweeping cannot produce dense gas at the rate required to match the cloud destruction rate. On the other hand, Toomre gravitational instability can reach the required production rate. We thus argue that, although dense, star-forming gas may last only around a single global free-fall time; the dense gas in star-forming galaxies can globally exist in a state of dynamic equilibrium between formation by gravitational instability and disruption by stellar feedback. At redshift z ≳ 2, the Toomre instability timescale decreases, resulting in a prediction of higher molecular gas fractions at early times, in agreement with the observations.

  5. Faraday instability on patterned surfaces

    Science.gov (United States)

    Feng, Jie; Rubinstein, Gregory; Jacobi, Ian; Stone, Howard

    2013-11-01

    We show how micro-scale surface patterning can be used to control the onset of the Faraday instability in thin liquid films. It is well known that when a liquid film on a planar substrate is subject to sufficient vibrational accelerations, the free surface destabilizes, exhibiting a family of non-linear standing waves. This instability remains a canonical problem in the study of spontaneous pattern formation, but also has practical uses. For example, the surface waves induced by the Faraday instability have been studied as a means of enhanced damping for mechanical vibrations (Genevaux et al. 2009). Also the streaming within the unstable layer has been used as a method for distributing heterogeneous cell cultures on growth medium (Takagi et al. 2002). In each of these applications, the roughness of the substrate significantly affects the unstable flow field. We consider the effect of patterned substrates on the onset and behavior of the Faraday instability over a range of pattern geometries and feature heights where the liquid layer is thicker than the pattern height. Also, we describe a physical model for the influence of patterned roughness on the destabilization of a liquid layer in order to improve the design of practical systems which exploit the Faraday instability.

  6. Cloud Cover

    Science.gov (United States)

    Schaffhauser, Dian

    2012-01-01

    This article features a major statewide initiative in North Carolina that is showing how a consortium model can minimize risks for districts and help them exploit the advantages of cloud computing. Edgecombe County Public Schools in Tarboro, North Carolina, intends to exploit a major cloud initiative being refined in the state and involving every…

  7. Cloud Control

    Science.gov (United States)

    Ramaswami, Rama; Raths, David; Schaffhauser, Dian; Skelly, Jennifer

    2011-01-01

    For many IT shops, the cloud offers an opportunity not only to improve operations but also to align themselves more closely with their schools' strategic goals. The cloud is not a plug-and-play proposition, however--it is a complex, evolving landscape that demands one's full attention. Security, privacy, contracts, and contingency planning are all…

  8. Helicobacter pylori infection generates genetic instability in gastric cells

    DEFF Research Database (Denmark)

    Machado, Ana Manuel Dantas; Figueiredo, Céu; Seruca, Raquel

    2010-01-01

    The discovery that Helicobacter pylori is associated with gastric cancer has led to numerous studies that investigate the mechanisms by which H. pylori induces carcinogenesis. Gastric cancer shows genetic instability both in nuclear and mitochondrial DNA, besides impairment of important DNA repair...... of the host, such as oxidative damage, methylation, chromosomal instability, microsatellite instability, and mutations. Interestingly, H. pylori infection generates genetic instability in nuclear and mitochondrial DNA. Based on the reviewed literature we conclude that H. pylori infection promotes gastric...

  9. Galloping instability to chaos of cables

    CERN Document Server

    Luo, Albert C J

    2017-01-01

    This book provides students and researchers with a systematic solution for fluid-induced structural vibrations, galloping instability and the chaos of cables. They will also gain a better understanding of stable and unstable periodic motions and chaos in fluid-induced structural vibrations. Further, the results presented here will help engineers effectively design and analyze fluid-induced vibrations.

  10. Annealing, temperature, and bias-induced threshold voltage instabilities in integrated E/D-mode InAlN/GaN MOS HEMTs

    Science.gov (United States)

    Blaho, M.; Gregušová, D.; Haščík, Š.; Ťapajna, M.; Fröhlich, K.; Šatka, A.; Kuzmík, J.

    2017-07-01

    Threshold voltage instabilities are examined in self-aligned E/D-mode n++ GaN/InAlN/GaN MOS HEMTs with a gate length of 2 μm and a source-drain spacing of 10 μm integrated in a logic invertor. The E-mode MOS HEMT technology is based on selective dry etching of the cap layer which is combined with Al2O3 grown by atomic-layer deposition at 380 K. In the D-mode MOS HEMT, the gate recessing is skipped. The nominal threshold voltage (VT) of E/D-mode MOS HEMTs was 0.6 and -3.4 V, respectively; the technology invariant maximal drain current was about 0.45 A/mm. Analysis after 580 K/15 min annealing step and at an elevated temperature up to 430 K reveals opposite device behavior depending on the HEMT operational mode. It was found that the annealing step decreases VT of the D-mode HEMT due to a reduced electron injection into the modified oxide. On the other hand, VT of the E-mode HEMT increases with reduced density of surface donors at the oxide/InAlN interface. Operation at the elevated temperature produces reversible changes: increase/decrease in the VT of the respective D-/E-mode HEMTs. Additional bias-induced experiments exhibit complex trapping phenomena in the devices: Coaction of shallow (˜0.1 eV below EC) traps in the GaN buffer and deep levels at the oxide/InAlN interface was identified for the E-mode device, while trapping in the D-mode HEMTs was found to be consistent with a thermo-ionic injection of electrons into bulk oxide traps (˜0.14 eV above EF) and trapping at the oxide/GaN cap interface states.

  11. Cloud Computing Fundamentals

    Science.gov (United States)

    Furht, Borko

    In the introductory chapter we define the concept of cloud computing and cloud services, and we introduce layers and types of cloud computing. We discuss the differences between cloud computing and cloud services. New technologies that enabled cloud computing are presented next. We also discuss cloud computing features, standards, and security issues. We introduce the key cloud computing platforms, their vendors, and their offerings. We discuss cloud computing challenges and the future of cloud computing.

  12. Posterolateral elbow joint instability

    DEFF Research Database (Denmark)

    Olsen, Bo Sanderhoff; Søjbjerg, Jens Ole; Nielsen, K K

    1998-01-01

    Thirty-five osteoligamentous elbows were included in a study on the kinematics of posterolateral elbow joint instability during the pivot shift test (PST) before and after separate ligament cuttings in the lateral collateral ligament complex (LCLC). Division of the annular ligament or the lateral...... ulnar collateral ligament caused no laxity during the PST. Division of the lateral collateral ligament caused maximal laxity of 4 degrees and 23 degrees during forced PST in valgus and external rotation (supination), respectively. Cutting of the LCLC at the ulnar or the humeral insertion was necessary...... for any PST stressed elbow joint laxity to occur. Total division of the LCLC induced a maximal laxity of 7.9 degrees and 37 degrees during forced PST in valgus and external rotation (supination), respectively. This study suggests the lateral collateral ligament to be the primary soft tissue constraint...

  13. Cloud Computing

    CERN Document Server

    Baun, Christian; Nimis, Jens; Tai, Stefan

    2011-01-01

    Cloud computing is a buzz-word in today's information technology (IT) that nobody can escape. But what is really behind it? There are many interpretations of this term, but no standardized or even uniform definition. Instead, as a result of the multi-faceted viewpoints and the diverse interests expressed by the various stakeholders, cloud computing is perceived as a rather fuzzy concept. With this book, the authors deliver an overview of cloud computing architecture, services, and applications. Their aim is to bring readers up to date on this technology and thus to provide a common basis for d

  14. Instabilities in inhomogeneous plasma

    International Nuclear Information System (INIS)

    Mikhailovsky, A.B.

    1983-01-01

    The plasma inhomogeneity across the magnetic field causes a wide class of instabilities which are called instabilities of an inhomogeneous plasma or gradient instabilities. The instabilities that can be studied in the approximation of a magnetic field with parallel straight field lines are treated first, followed by a discussion of the influence of shear on these instabilities. The instabilities of a weakly inhomogeneous plasma with the Maxwellian velocity distribution of particles caused by the density and temperature gradients are often called drift instabilities, and the corresponding types of perturbations are the drift waves. An elementary theory of drift instabilities is presented, based on the simplest equations of motion of particles in the field of low-frequency and long-wavelength perturbations. Following that is a more complete theory of inhomogeneous collisionless plasma instabilities which uses the permittivity tensor and, in the case of electrostatic perturbations, the scalar of permittivity. The results are used to study the instabilities of a strongly inhomogeneous plasma. The instabilities of a plasma in crossed fields are discussed and the electromagnetic instabilities of plasma with finite and high pressure are described. (Auth.)

  15. Interstellar clouds and the formation of stars

    Energy Technology Data Exchange (ETDEWEB)

    Alfven, H; Carlqvist, P [Kungliga Tekniska Hoegskolan, Stockholm (Sweden). Institutionen foer Plasmafysik

    1978-05-01

    Part I gives a survey of the drastic revision of cosmic plasma physics which is precipitated by the exploration of the magnetosphere through in situ measurements. The 'pseudo-plasma formalism', which until now has almost completely dominated theoretical astrophysics, must be replaced by an experimentally based approach involving the introduction of a number of neglected plasma phenomena, such as electric double layers, critical velocity, and pinch effect. The general belief that star light is the main ionizer is shown to be doubtful; hydromagnetic conversion of gravitational and kinetic energy may often be much more important. In Part II the revised plasma physics is applied to dark clouds and star formation. Magnetic fields do not necessarily counteract the contraction of a cloud; they may just as well 'pinch' the cloud. Magnetic compression may be the main mechanism for forming interstellar clouds and keeping them together. Part III treats the formation of stars in a dusty cosmic plasma cloud. Star formation is due to an instability, but it is very unlikely that it has anything to do with the Jeans instability. A reasonable mechanism is that the sedimentation of 'dust' (including solid bodies of different size) is triggering off a gravitationally assisted accretion. A 'stellesimal' accretion analogous to the planetesimal accretion leads to the formation of a star surrounded by a very low density hollow in the cloud. Matter falling in from the cloud towards the star is the raw material for the formation of planets and satellites.

  16. Cloud Computing

    DEFF Research Database (Denmark)

    Krogh, Simon

    2013-01-01

    with technological changes, the paradigmatic pendulum has swung between increased centralization on one side and a focus on distributed computing that pushes IT power out to end users on the other. With the introduction of outsourcing and cloud computing, centralization in large data centers is again dominating...... the IT scene. In line with the views presented by Nicolas Carr in 2003 (Carr, 2003), it is a popular assumption that cloud computing will be the next utility (like water, electricity and gas) (Buyya, Yeo, Venugopal, Broberg, & Brandic, 2009). However, this assumption disregards the fact that most IT production......), for instance, in establishing and maintaining trust between the involved parties (Sabherwal, 1999). So far, research in cloud computing has neglected this perspective and focused entirely on aspects relating to technology, economy, security and legal questions. While the core technologies of cloud computing (e...

  17. Mobile Clouds

    DEFF Research Database (Denmark)

    Fitzek, Frank; Katz, Marcos

    A mobile cloud is a cooperative arrangement of dynamically connected communication nodes sharing opportunistic resources. In this book, authors provide a comprehensive and motivating overview of this rapidly emerging technology. The book explores how distributed resources can be shared by mobile...... users in very different ways and for various purposes. The book provides many stimulating examples of resource-sharing applications. Enabling technologies for mobile clouds are also discussed, highlighting the key role of network coding. Mobile clouds have the potential to enhance communications...... performance, improve utilization of resources and create flexible platforms to share resources in very novel ways. Energy efficient aspects of mobile clouds are discussed in detail, showing how being cooperative can bring mobile users significant energy saving. The book presents and discusses multiple...

  18. Instability of expanded simple tandem repeats is induced in cell culture by a variety of agents: N-Nitroso-N-ethylurea, benzo(a)pyrene, etoposide and okadaic acid

    International Nuclear Information System (INIS)

    Polyzos, Aris; Parfett, Craig; Healy, Caroline; Douglas, George R.; Yauk, Carole L.

    2006-01-01

    Expanded simple tandem repeat (ESTR) sequences have proven useful biomarkers to detect genotoxicity in vivo. Their high sensitivity has been used to assess environmentally relevant doses of mutagens such as ionizing radiation, DNA alkylating agents and airborne particulate pollution, for germline mutations in mouse assays. The mutagenic response involves size alteration of these ESTR loci induced by agents causing a variety of cellular damage. The mechanistic aspects of this induced instability remain unclear and have not been studied in detail. Mechanistic knowledge is important to help understand the relevance of increased ESTR mutation frequencies. In this study, we applied a murine cell culture system to examine induced response to four agents exhibiting different modes of toxic action including: N-nitroso-N-ethylurea (ENU), benzo(a)pyrene (BaP), okadaic acid and etoposide at slightly sub-toxic levels. We used single-molecule-polymerase chain reaction (SM-PCR) to assess the relative mutant frequency after 4-week chemical treatments at the Ms6-hm ESTR sequence of cultured C3H/10T1/2 cells (a mouse embryonic cell line). Increased mutation was observed with both 0.64 mM ENU (1.95-fold increase, P < 0.0001), 1 μM benzo(a)pyrene (1.87-fold increase, P = 0.0006) and 3 nM etoposide (1.89-fold increase, P = 0.0003). The putative ESTR mutagen okadaic acid (1.27-fold increase, P = 0.2289), administered at 0.5 nM, did not affect the C3H/10T1/2 Ms6-hm locus. Therefore, agents inducing small and bulky adducts, and indirectly causing strand breaks through inhibition of topoisomerase, caused similar induction of instability at an ESTR locus at matched toxicities. As size spectra for induced mutations were identical, the data indicate that although these chemicals exhibit distinct modes of action, a similar indirect process is influencing ESTR instability. In contrast, a potent tumour promoter that is a kinase inhibitor does not contribute to induced ESTR instability in cell

  19. Instability of expanded simple tandem repeats is induced in cell culture by a variety of agents: N-Nitroso-N-ethylurea, benzo(a)pyrene, etoposide and okadaic acid

    Energy Technology Data Exchange (ETDEWEB)

    Polyzos, Aris [Environmental Health Centre, Environmental and occupational Toxicology Division, Health Canada, Tunney' s Pasture, P.L. 0803A, Ottawa, Ont., K1A 0L2 (Canada); Parfett, Craig [Environmental Health Centre, Environmental and occupational Toxicology Division, Health Canada, Tunney' s Pasture, P.L. 0803A, Ottawa, Ont., K1A 0L2 (Canada); Healy, Caroline [Environmental Health Centre, Environmental and occupational Toxicology Division, Health Canada, Tunney' s Pasture, P.L. 0803A, Ottawa, Ont., K1A 0L2 (Canada); Douglas, George R. [Environmental Health Centre, Environmental and occupational Toxicology Division, Health Canada, Tunney' s Pasture, P.L. 0803A, Ottawa, Ont., K1A 0L2 (Canada); Yauk, Carole L. [Environmental Health Centre, Environmental and occupational Toxicology Division, Health Canada, Tunney' s Pasture, P.L. 0803A, Ottawa, Ont., K1A 0L2 (Canada)]. E-mail: Carole_Yauk@hc-sc.gc.ca

    2006-06-25

    Expanded simple tandem repeat (ESTR) sequences have proven useful biomarkers to detect genotoxicity in vivo. Their high sensitivity has been used to assess environmentally relevant doses of mutagens such as ionizing radiation, DNA alkylating agents and airborne particulate pollution, for germline mutations in mouse assays. The mutagenic response involves size alteration of these ESTR loci induced by agents causing a variety of cellular damage. The mechanistic aspects of this induced instability remain unclear and have not been studied in detail. Mechanistic knowledge is important to help understand the relevance of increased ESTR mutation frequencies. In this study, we applied a murine cell culture system to examine induced response to four agents exhibiting different modes of toxic action including: N-nitroso-N-ethylurea (ENU), benzo(a)pyrene (BaP), okadaic acid and etoposide at slightly sub-toxic levels. We used single-molecule-polymerase chain reaction (SM-PCR) to assess the relative mutant frequency after 4-week chemical treatments at the Ms6-hm ESTR sequence of cultured C3H/10T1/2 cells (a mouse embryonic cell line). Increased mutation was observed with both 0.64 mM ENU (1.95-fold increase, P < 0.0001), 1 {mu}M benzo(a)pyrene (1.87-fold increase, P = 0.0006) and 3 nM etoposide (1.89-fold increase, P = 0.0003). The putative ESTR mutagen okadaic acid (1.27-fold increase, P = 0.2289), administered at 0.5 nM, did not affect the C3H/10T1/2 Ms6-hm locus. Therefore, agents inducing small and bulky adducts, and indirectly causing strand breaks through inhibition of topoisomerase, caused similar induction of instability at an ESTR locus at matched toxicities. As size spectra for induced mutations were identical, the data indicate that although these chemicals exhibit distinct modes of action, a similar indirect process is influencing ESTR instability. In contrast, a potent tumour promoter that is a kinase inhibitor does not contribute to induced ESTR instability in

  20. Cloud fluid compression and softening in spiral arms and the formation of giant molecular cloud complexes

    International Nuclear Information System (INIS)

    Cowie, L.L.

    1981-01-01

    In this, the second paper of a series on the galactodynamics of the cloudy interstellar medium, we consider the response of such a gas to a forcing potential in the tight-winding density wave theory. The cloud fluid is treated in the hydrodynamic limit with an equation of state which softens at high densities. It is shown that in the inner regions of the galaxy, cooling of the cloud fluid in the arms can result in gravitational instability and the formation of large bound complexes of clouds which we identify with the giant molecular clouds (GMCs). Masses dimensions, distributions, and scale heights of the GMCs are predicted by the theory. It is suggested that the interstellar gas density in the disk is regulated by the gravitational instability mechanism in the arms which siphons material into star formation. Implications for the evolution of individual GMCs and for galactic morphology are discussed

  1. Molecular line observations of infrared dark clouds in the galaxy

    Science.gov (United States)

    Finn, Susanna C.

    Although massive stars play many important roles in the universe, their formation is poorly understood. Recently, a class of interstellar clouds known as Infrared Dark Clouds (IRDCs) has been identified as likely progenitors of massive stars and clusters. These clouds are dense (nH 2 > 105 cm--3), cold (T Nessie Nebula," an extreme case of a filamentary IRDC, with predictions from the theory of the fluid instability and then expand the sample to other filamentary IRDCs. The observations are consistent with theoretical predictions of clump spacing, clump masses, and linear mass density. Fragmentation of filaments due to the sausage instability might be the dominant mode of star formation in the Universe.

  2. SPH simulations of star/planet formation triggered by cloud-cloud collisions

    OpenAIRE

    Kitsionas, Spyridon; Whitworth, Anthony Peter; Klessen, Ralf S.

    2007-01-01

    We present results of hydrodynamic simulations of star formation triggered by cloud-cloud collisions. During the early stages of star formation, low-mass objects form by gravitational instabilities in protostellar discs. A number of these low-mass objects are in the sub-stellar mass range, including a few objects of planetary mass. The disc instabilities that lead to the formation of low-mass objects in our simulations are the product of disc-disc interactions and/or interactions between the ...

  3. Two cloud-point phenomena in tetrabutylammonium perfluorooctanoate aqueous solutions: anomalous temperature-induced phase and structure transitions.

    Science.gov (United States)

    Yan, Peng; Huang, Jin; Lu, Run-Chao; Jin, Chen; Xiao, Jin-Xin; Chen, Yong-Ming

    2005-03-24

    This paper reported the phase behavior and aggregate structure of tetrabutylammonium perfluorooctanoate (TBPFO), determined by differential scanning calorimeter, electrical conductivity, static/dynamic light scattering, and rheology methods. We found that above a certain concentration the TBPFO solution showed anomalous temperature-dependent phase behavior and structure transitions. Such an ionic surfactant solution exhibits two cloud points. When the temperature was increased, the solution turned from a homogeneous-phase to a liquid-liquid two-phase system, then to another homogeneous-phase, and finally to another liquid-liquid two-phase system. In the first homogeneous-phase region, the aggregates of TBPFO were rodlike micelles and the solution was Newtonian fluid. While in the second homogeneous-phase region, the aggregates of TBPFO were large wormlike micelles, and the solution behaved as pseudoplastic fluid that also exhibited viscoelastic behavior. We thought that the first cloud point might be caused by the "bridge" effect of the tetrabutylammonium counterion between the micelles and the second one by the formation of the micellar network.

  4. Cinerama sickness and postural instability.

    Science.gov (United States)

    Bos, Jelte E; Ledegang, Wietse D; Lubeck, Astrid J A; Stins, John F

    2013-01-01

    Motion sickness symptoms and increased postural instability induced by motion pictures have been reported in a laboratory, but not in a real cinema. We, therefore, carried out an observational study recording sickness severity and postural instability in 19 subjects before, immediately and 45 min after watching a 1 h 3D aviation documentary in a cinema. Sickness was significantly larger right after the movie than before, and in a lesser extent still so after 45 min. The average standard deviation of the lateral centre of pressure excursions was significantly larger only right afterwards. When low-pass filtered at 0.1 Hz, lateral and for-aft excursions were both significantly larger right after the movie, while for-aft excursions then remained larger even after 45 min. Speculating on previous findings, we predict more sickness and postural instability in 3D than in 2D movies, also suggesting a possible, but yet unknown risk for work-related activities and vehicle operation. Watching motion pictures may be sickening and posturally destabilising, but effects in a cinema are unknown. We, therefore, carried out an observational study showing that sickness then is mainly an issue during the exposure while postural instability is an issue afterwards.

  5. Bosonic instability of charged black holes

    International Nuclear Information System (INIS)

    Gaina, A.B.; Ternov, I.M.

    1986-01-01

    The processes of spontaneous and induced production and accumulation of charged bosons on quasibound superradiant levels in the field of Kerr-Newman black hole is analysed. It is shown that bosonic instability may be caused exclusively by the rotation of the black hole. Particulary, the Reissner-Nordstrom configuration is stable. In the case of rotating and charged black hole the bosonic instability may cause an increase of charge of the black hole

  6. Beam Instabilities in Circular Particle Accelerators

    CERN Document Server

    AUTHOR|(CDS)2067185

    2017-01-01

    The theory of impedance-induced bunched-beam coherent instabilities is reviewed following Laclare's formalism, adding the effect of an electronic damper in the transverse plane. Both single-bunch and coupled-bunch instabilities are discussed, both low-intensity and high-intensity regimes are analysed, both longitudinal and transverse planes are studied, and both short-bunch and long-bunch regimes are considered. Observables and mitigation measures are also examined.

  7. Nonlinear Dynamics Mechanism of Rock Burst Induced by the Instability of the Layer-Crack Plate Structure in the Coal Wall in Deep Coal Mining

    Directory of Open Access Journals (Sweden)

    Yanlong Chen

    2017-01-01

    Full Text Available The instability of layer-crack plate structure in coal wall is one of the causes of rock burst. In the present paper, we investigate the formation and instability processes of layer-crack plate structure in coal wall by experiments and theoretical analysis. The results reveal that layer-crack plate structure formed near the free surface of the coal wall during the loading. During the formation of the layer-crack plate structure, the lateral displacement curve of the coal wall experiences a jagged variation, which suggests the nonlinear instability failure of the coal wall with a sudden release of the elastic energy. Then, a dynamic model for the stability analysis of the layer-crack plate structure was proposed, which takes consideration of the dynamic disturbance factor. Based on the dynamic model, the criterion for dynamic instability of the layer-crack plate structure was determined and demonstrated by an example. According to the analytical results, some control methods of dynamic stability of the layer-crack plate structure was put forward.

  8. Janus faces of Jeans instabilities

    International Nuclear Information System (INIS)

    Verheest, Frank; Jacobs, Gerald; Cadez, Vladimir M.

    2000-01-01

    Self-gravitating clouds have been shown by Jeans to be unstable to harmonic perturbations whose wavelength exceeds some critical value involving the mass density and some thermal velocity or equivalent information. Based upon the assumption that the unperturbed cloud is initially uniform, the Jeans instability is non-oscillatory and purely growing. However, Newtonian gravitation precludes strictly homogeneous equilibria, but a way out is offered, in theory, by considering local perturbations, small compared to the inhomogeneity scale lengths. While in itself plausible, this procedure can in most cases not be tested for internal consistency, because real knowledge about the equilibrium is lacking, and is therefore called the Jeans swindle. The severe limitations of such an approach lead to an unavoidable dichotomy, and an example of a plasma will be discussed where the computations can be done explicitly, both for the stationary as well as for the perturbed state, showing that the system is stable at all wavelengths compatible with the equilibrium inhomogeneity. Nevertheless, the present state of affairs does not allow self-consistent equilibria to be worked out in more complicated configurations, like in dusty plasmas with external magnetic fields. This typically leads to the Jeans swindle being used a little longer than desirable

  9. Electron clouds in high energy hadron accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Petrov, Fedor

    2013-08-29

    The formation of electron clouds in accelerators operating with positrons and positively charge ions is a well-known problem. Depending on the parameters of the beam the electron cloud manifests itself differently. In this thesis the electron cloud phenomenon is studied for the CERN Super Proton Synchrotron (SPS) and Large Hadron Collider (LHC) conditions, and for the heavy-ion synchrotron SIS-100 as a part of the FAIR complex in Darmstadt, Germany. Under the FAIR conditions the extensive use of slow extraction will be made. After the acceleration the beam will be debunched and continuously extracted to the experimental area. During this process, residual gas electrons can accumulate in the electric field of the beam. If this accumulation is not prevented, then at some point the beam can become unstable. Under the SPS and LHC conditions the beam is always bunched. The accumulation of electron cloud happens due to secondary electron emission. At the time when this thesis was being written the electron cloud was known to limit the maximum intensity of the two machines. During the operation with 25 ns bunch spacing, the electron cloud was causing significant beam quality deterioration. At moderate intensities below the instability threshold the electron cloud was responsible for the bunch energy loss. In the framework of this thesis it was found that the instability thresholds of the coasting beams with similar space charge tune shifts, emittances and energies are identical. First of their kind simulations of the effect of Coulomb collisions on electron cloud density in coasting beams were performed. It was found that for any hadron coasting beam one can choose vacuum conditions that will limit the accumulation of the electron cloud below the instability threshold. We call such conditions the ''good'' vacuum regime. In application to SIS-100 the design pressure 10{sup -12} mbar corresponds to the good vacuum regime. The transition to the bad vacuum

  10. Soft Clouding

    DEFF Research Database (Denmark)

    Søndergaard, Morten; Markussen, Thomas; Wetton, Barnabas

    2012-01-01

    Soft Clouding is a blended concept, which describes the aim of a collaborative and transdisciplinary project. The concept is a metaphor implying a blend of cognitive, embodied interaction and semantic web. Furthermore, it is a metaphor describing our attempt of curating a new semantics of sound...... archiving. The Soft Clouding Project is part of LARM - a major infrastructure combining research in and access to sound and radio archives in Denmark. In 2012 the LARM infrastructure will consist of more than 1 million hours of radio, combined with metadata who describes the content. The idea is to analyse...... the concept of ‘infrastructure’ and ‘interface’ on a creative play with the fundamentals of LARM (and any sound archive situation combining many kinds and layers of data and sources). This paper will present and discuss the Soft clouding project from the perspective of the three practices and competencies...

  11. Longwave indirect effect of mineral dusts on ice clouds

    Directory of Open Access Journals (Sweden)

    Q. Min

    2010-08-01

    Full Text Available In addition to microphysical changes in clouds, changes in nucleation processes of ice cloud due to aerosols would result in substantial changes in cloud top temperature as mildly supercooled clouds are glaciated through heterogenous nucleation processes. Measurements from multiple sensors on multiple observing platforms over the Atlantic Ocean show that the cloud effective temperature increases with mineral dust loading with a slope of +3.06 °C per unit aerosol optical depth. The macrophysical changes in ice cloud top distributions as a consequence of mineral dust-cloud interaction exert a strong cooling effect (up to 16 Wm−2 of thermal infrared radiation on cloud systems. Induced changes of ice particle size by mineral dusts influence cloud emissivity and play a minor role in modulating the outgoing longwave radiation for optically thin ice clouds. Such a strong cooling forcing of thermal infrared radiation would have significant impacts on cloud systems and subsequently on climate.

  12. GIANT MOLECULAR CLOUD FORMATION IN DISK GALAXIES: CHARACTERIZING SIMULATED VERSUS OBSERVED CLOUD CATALOGS

    Energy Technology Data Exchange (ETDEWEB)

    Benincasa, Samantha M.; Pudritz, Ralph E.; Wadsley, James [Department of Physics and Astronomy, McMaster University, Hamilton, ON L8S 4M1 (Canada); Tasker, Elizabeth J. [Department of Physics, Faculty of Science, Hokkaido University, Kita-ku, Sapporo 060-0810 (Japan)

    2013-10-10

    We present the results of a study of simulated giant molecular clouds (GMCs) formed in a Milky Way-type galactic disk with a flat rotation curve. This simulation, which does not include star formation or feedback, produces clouds with masses ranging between 10{sup 4} M{sub ☉} and 10{sup 7} M{sub ☉}. We compare our simulated cloud population to two observational surveys: the Boston University-Five College Radio Astronomy Observatory Galactic Ring Survey and the BIMA All-Disk Survey of M33. An analysis of the global cloud properties as well as a comparison of Larson's scaling relations is carried out. We find that simulated cloud properties agree well with the observed cloud properties, with the closest agreement occurring between the clouds at comparable resolution in M33. Our clouds are highly filamentary—a property that derives both from their formation due to gravitational instability in the sheared galactic environment, as well as to cloud-cloud gravitational encounters. We also find that the rate at which potentially star-forming gas accumulates within dense regions—wherein n{sub thresh} ≥ 10{sup 4} cm{sup –3}—is 3% per 10 Myr, in clouds of roughly 10{sup 6} M{sub ☉}. This suggests that star formation rates in observed clouds are related to the rates at which gas can be accumulated into dense subregions within GMCs via filamentary flows. The most internally well-resolved clouds are chosen for listing in a catalog of simulated GMCs—the first of its kind. The cataloged clouds are available as an extracted data set from the global simulation.

  13. Cloud Chamber

    DEFF Research Database (Denmark)

    Gfader, Verina

    Cloud Chamber takes its roots in a performance project, titled The Guests 做东, devised by Verina Gfader for the 11th Shanghai Biennale, ‘Why Not Ask Again: Arguments, Counter-arguments, and Stories’. Departing from the inclusion of the biennale audience to write a future folk tale, Cloud Chamber......: fiction and translation and translation through time; post literacy; world picturing-world typing; and cartographic entanglements and expressions of subjectivity; through the lens a social imaginary of worlding or cosmological quest. Art at its core? Contributions by Nikos Papastergiadis, Rebecca Carson...

  14. Experimental study on low pressure flow instability

    International Nuclear Information System (INIS)

    Jiang Shengyao; Wu Xinxin; Wu Shaorong; Bo Jinhai; Zhang Youjie

    1997-05-01

    The experiment was performed on the test loop (HRTL-5), which simulates the geometry and system design of the 5 MW reactor. The flow behavior for a wide range of inlet subcooling, in which the flow undergoes from single phase to two phase, is described in a natural circulation system at low pressure (p = 0.1, 0.24 MPa). Several kinds of flow instability, e.g. subcooled boiling instability, subcooled boiling induced flashing instability, pure flashing instability as well as flashing coupled density wave instability and high frequency flow oscillation, are investigated. The mechanism of flashing and flashing concerned flow instability, which has never been studied well in this field, is especially interpreted. The experimental results show that, firstly, for a low pressure natural circulation system the two phase flow is unstable in most of inlet subcooling conditions, the two phase stable flow can only be reached at very low inlet subcooling; secondly, at high inlet subcooling the flow instability is dominated by subcooled boiling in the heated section, and at middle inlet subcooling is dominated by void flashing in the adiabatic long riser; thirdly, in two phase stable flow region the condition for boiling out of the core, namely, single phase flow in the heated section, two phase flow in the riser due to vapor flashing, can be realized. The experimental results are very important for the design and accident analysis of the vessel and swimming pool type natural circulation nuclear heating reactor. (7 refs., 10 figs., 1 tab.)

  15. PIC simulation of a thermal anisotropy-driven Weibel instability in a circular rarefaction wave

    International Nuclear Information System (INIS)

    Dieckmann, M E; Sarri, G; Kourakis, I; Borghesi, M; Murphy, G C; O'C Drury, L; Bret, A; Romagnani, L; Ynnerman, A

    2012-01-01

    The expansion of an initially unmagnetized planar rarefaction wave has recently been shown to trigger a thermal anisotropy-driven Weibel instability (TAWI), which can generate magnetic fields from noise levels. It is examined here whether the TAWI can also grow in a curved rarefaction wave. The expansion of an initially unmagnetized circular plasma cloud, which consists of protons and hot electrons, into a vacuum is modelled for this purpose with a two-dimensional particle-in-cell (PIC) simulation. It is shown that the momentum transfer from the electrons to the radially accelerating protons can indeed trigger a TAWI. Radial current channels form and the aperiodic growth of a magnetowave is observed, which has a magnetic field that is oriented orthogonal to the simulation plane. The induced electric field implies that the electron density gradient is no longer parallel to the electric field. Evidence is presented here that this electric field modification triggers a second magnetic instability, which results in a rotational low-frequency magnetowave. The relevance of the TAWI is discussed for the growth of small-scale magnetic fields in astrophysical environments, which are needed to explain the electromagnetic emissions by astrophysical jets. It is outlined how this instability could be examined experimentally. (paper)

  16. PIC simulation of a thermal anisotropy-driven Weibel instability in a circular rarefaction wave

    Science.gov (United States)

    Dieckmann, M. E.; Sarri, G.; Murphy, G. C.; Bret, A.; Romagnani, L.; Kourakis, I.; Borghesi, M.; Ynnerman, A.; O'C Drury, L.

    2012-02-01

    The expansion of an initially unmagnetized planar rarefaction wave has recently been shown to trigger a thermal anisotropy-driven Weibel instability (TAWI), which can generate magnetic fields from noise levels. It is examined here whether the TAWI can also grow in a curved rarefaction wave. The expansion of an initially unmagnetized circular plasma cloud, which consists of protons and hot electrons, into a vacuum is modelled for this purpose with a two-dimensional particle-in-cell (PIC) simulation. It is shown that the momentum transfer from the electrons to the radially accelerating protons can indeed trigger a TAWI. Radial current channels form and the aperiodic growth of a magnetowave is observed, which has a magnetic field that is oriented orthogonal to the simulation plane. The induced electric field implies that the electron density gradient is no longer parallel to the electric field. Evidence is presented here that this electric field modification triggers a second magnetic instability, which results in a rotational low-frequency magnetowave. The relevance of the TAWI is discussed for the growth of small-scale magnetic fields in astrophysical environments, which are needed to explain the electromagnetic emissions by astrophysical jets. It is outlined how this instability could be examined experimentally.

  17. Cloud computing.

    Science.gov (United States)

    Wink, Diane M

    2012-01-01

    In this bimonthly series, the author examines how nurse educators can use Internet and Web-based technologies such as search, communication, and collaborative writing tools; social networking and social bookmarking sites; virtual worlds; and Web-based teaching and learning programs. This article describes how cloud computing can be used in nursing education.

  18. Cloud Computing

    Indian Academy of Sciences (India)

    IAS Admin

    2014-03-01

    Mar 1, 2014 ... There are several types of services available on a cloud. We describe .... CPU speed has been doubling every 18 months at constant cost. Besides this ... Plain text (e.g., email) may be read by anyone who is able to access it.

  19. Experimental study of linear and nonlinear regimes of density-driven instabilities induced by CO{sub 2} dissolution in water

    Energy Technology Data Exchange (ETDEWEB)

    Outeda, R.; D' Onofrio, A. [Grupo de Medios Porosos, Facultad de Ingeniería, Universidad de Buenos Aires, Paseo Colón 850, C1063ACV Buenos Aires (Argentina); El Hasi, C.; Zalts, A. [Instituto de Ciencias, Universidad Nacional General Sarmiento, J. M. Gutiérrez 1150, B1613GSX, Los Polvorines, Provincia de Buenos Aires (Argentina)

    2014-03-15

    Density driven instabilities produced by CO{sub 2} (gas) dissolution in water containing a color indicator were studied in a Hele Shaw cell. The images were analyzed and instability patterns were characterized by mixing zone temporal evolution, dispersion curves, and the growth rate for different CO{sub 2} pressures and different color indicator concentrations. The results obtained from an exhaustive analysis of experimental data show that this system has a different behaviour in the linear regime of the instabilities (when the growth rate has a linear dependence with time), from the nonlinear regime at longer times. At short times using a color indicator to see the evolution of the pattern, the images show that the effects of both the color indicator and CO{sub 2} pressure are of the same order of magnitude: The growth rates are similar and the wave numbers are in the same range (0–30 cm{sup −1}) when the system is unstable. Although in the linear regime the dynamics is affected similarly by the presence of the indicator and CO{sub 2} pressure, in the nonlinear regime, the influence of the latter is clearly more pronounced than the effects of the color indicator.

  20. Outflow-Induced Dynamical and Radiative Instability in Stellar Envelopes with an Application to Luminous Blue Variables and Wolf-Rayet Stars

    Science.gov (United States)

    Stothers, Richard B.; Hansen, James E. (Technical Monitor)

    2002-01-01

    Theoretical models of the remnants of massive stars in a very hot, post-red-supergiant phase display no obvious instability if standard assumptions are made. However, the brightest observed classical luminous blue variables (LBVs) may well belong to such a phase. A simple time-dependent theory of moving stellar envelopes is developed in order to treat deep hydrodynamical disturbances caused by surface mass loss and to test the moving envelopes for dynamical instability. In the case of steady-state outflow, the theory reduces to the equivalent of the Castor, Abbott, and Klein formulation for optically thick winds at distances well above the sonic point. The time-dependent version indicates that the brightest and hottest LBVs are both dynamically and radiatively unstable, as a result of the substantial lowering of the generalized Eddington luminosity limit by the mass-loss acceleration. It is suggested that dynamical instability, by triggering secular cycles of mass loss, is primarily what differentiates LBVs from the purely radiatively unstable Wolf-Rayet stars. Furthermore, when accurate main-sequence mass-loss rates are used to calculate the evolutionary tracks, the predicted surface hydrogen and nitrogen abundances of the blue remnants agree much better with observations of the brightest LBVs than before.

  1. Hydrodynamic instabilities in inertial fusion

    International Nuclear Information System (INIS)

    Hoffman, N.M.

    1994-01-01

    This report discusses topics on hydrodynamics instabilities in inertial confinement: linear analysis of Rayleigh-Taylor instability; ablation-surface instability; bubble rise in late-stage Rayleigh-Taylor instability; and saturation and multimode interactions in intermediate-stage Rayleigh-Taylor instability

  2. LHC Report: Out of the clouds

    CERN Multimedia

    Giovanni Rumolo, Giovanni Iadarola and Hannes Bartosik for the LHC team

    2015-01-01

    In order for the LHC to deliver intense proton beams to the experiments, operators have to perform “scrubbing” of the beam pipes. This operation is necessary to reduce the formation of electron clouds, which would generate instabilities in the colliding beams.   Electron clouds are generated in accelerators running with positively charged particles when electrons - produced by the ionisation of residual molecules in the vacuum or by the photoelectric effect from synchrotron radiation - are accelerated by the beam field and hit the surface of the vacuum chamber producing other electrons. This avalanche-like process can result in the formation of clouds of electrons. Electron clouds are detrimental to the beam for a few reasons. First, the electrons impacting the walls desorb molecules and degrade the ultra-high vacuum in the beam chamber. Furthermore, they interact electromagnetically with the beam, leading to the oscillation and expansion of the particle bunches. This increases...

  3. Seeded Supercontinuum Generation - Modulation Instability Gain, Coherent and Incoherent Rogue Waves

    DEFF Research Database (Denmark)

    Sørensen, Simon Toft; Larsen, Casper; Møller, Uffe Visbech

    2012-01-01

    Deterministic supercontinuum can be generated by seeding the modulation instability-induced pulse break-up. We investigate the influence of the modulation instability gain on seeding and demonstrate the generation of coherent and incoherent rogue waves....

  4. Methylene Blue Is Effective to Reverse Refractory Hemodynamic Instability due to Dimethoate Poisoning

    Directory of Open Access Journals (Sweden)

    Nick Youssefi

    2015-09-01

    Conclusion:MB treatment was effective to reverse hypotension and restore hemodynamic instability caused by dimethoate poisoning. This index case may pave way to further investigation of MB therapy for OP-induced hemodynamic instabilities.

  5. Interactive HIV-1 Tat and morphine-induced synaptodendritic injury is triggered through focal disruptions in Na⁺ influx, mitochondrial instability, and Ca²⁺ overload.

    Science.gov (United States)

    Fitting, Sylvia; Knapp, Pamela E; Zou, Shiping; Marks, William D; Bowers, M Scott; Akbarali, Hamid I; Hauser, Kurt F

    2014-09-17

    Synaptodendritic injury is thought to underlie HIV-associated neurocognitive disorders and contributes to exaggerated inflammation and cognitive impairment seen in opioid abusers with HIV-1. To examine events triggering combined transactivator of transcription (Tat)- and morphine-induced synaptodendritic injury systematically, striatal neuron imaging studies were conducted in vitro. These studies demonstrated nearly identical pathologic increases in dendritic varicosities as seen in Tat transgenic mice in vivo. Tat caused significant focal increases in intracellular sodium ([Na(+)]i) and calcium ([Ca(2+)]i) in dendrites that were accompanied by the emergence of dendritic varicosities. These effects were largely, but not entirely, attenuated by the NMDA and AMPA receptor antagonists MK-801 and CNQX, respectively. Concurrent morphine treatment accelerated Tat-induced focal varicosities, which were accompanied by localized increases in [Ca(2+)]i and exaggerated instability in mitochondrial inner membrane potential. Importantly, morphine's effects were prevented by the μ-opioid receptor antagonist CTAP and were not observed in neurons cultured from μ-opioid receptor knock-out mice. Combined Tat- and morphine-induced initial losses in ion homeostasis and increases in [Ca(2+)]i were attenuated by the ryanodine receptor inhibitor ryanodine, as well as pyruvate. In summary, Tat induced increases in [Na(+)]i, mitochondrial instability, excessive Ca(2+) influx through glutamatergic receptors, and swelling along dendrites. Morphine, acting via μ-opioid receptors, exacerbates these excitotoxic Tat effects at the same subcellular locations by mobilizing additional [Ca(2+)]i and by further disrupting [Ca(2+)]i homeostasis. We hypothesize that the spatiotemporal relationship of μ-opioid and aberrant AMPA/NMDA glutamate receptor signaling is critical in defining the location and degree to which opiates exacerbate the synaptodendritic injury commonly observed in neuro

  6. Cloud management and security

    CERN Document Server

    Abbadi, Imad M

    2014-01-01

    Written by an expert with over 15 years' experience in the field, this book establishes the foundations of Cloud computing, building an in-depth and diverse understanding of the technologies behind Cloud computing. In this book, the author begins with an introduction to Cloud computing, presenting fundamental concepts such as analyzing Cloud definitions, Cloud evolution, Cloud services, Cloud deployment types and highlighting the main challenges. Following on from the introduction, the book is divided into three parts: Cloud management, Cloud security, and practical examples. Part one presents the main components constituting the Cloud and federated Cloud infrastructure(e.g., interactions and deployment), discusses management platforms (resources and services), identifies and analyzes the main properties of the Cloud infrastructure, and presents Cloud automated management services: virtual and application resource management services. Part two analyzes the problem of establishing trustworthy Cloud, discuss...

  7. Arsia Mons Spiral Cloud

    Science.gov (United States)

    2002-01-01

    One of the benefits of the Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) Extended Mission is the opportunity to observe how the planet's weather changes during a second full martian year. This picture of Arsia Mons was taken June 19, 2001; southern spring equinox occurred the same day. Arsia Mons is a volcano nearly large enough to cover the state of New Mexico. On this particular day (the first day of Spring), the MOC wide angle cameras documented an unusual spiral-shaped cloud within the 110 km (68 mi) diameter caldera--the summit crater--of the giant volcano. Because the cloud is bright both in the red and blue images acquired by the wide angle cameras, it probably consisted mostly of fine dust grains. The cloud's spin may have been induced by winds off the inner slopes of the volcano's caldera walls resulting from the temperature differences between the walls and the caldera floor, or by a vortex as winds blew up and over the caldera. Similar spiral clouds were seen inside the caldera for several days; we don't know if this was a single cloud that persisted throughout that time or one that regenerated each afternoon. Sunlight illuminates this scene from the left/upper left.Malin Space Science Systems and the California Institute of Technology built the MOC using spare hardware from the Mars Observer mission. MSSS operates the camera from its facilities in San Diego, CA. The Jet Propulsion Laboratory's Mars Surveyor Operations Project operates the Mars Global Surveyor spacecraft with its industrial partner, Lockheed Martin Astronautics, from facilities in Pasadena, CA and Denver, CO.

  8. Cloud time

    CERN Document Server

    Lockwood, Dean

    2012-01-01

    The ‘Cloud’, hailed as a new digital commons, a utopia of collaborative expression and constant connection, actually constitutes a strategy of vitalist post-hegemonic power, which moves to dominate immanently and intensively, organizing our affective political involvements, instituting new modes of enclosure, and, crucially, colonizing the future through a new temporality of control. The virtual is often claimed as a realm of invention through which capitalism might be cracked, but it is precisely here that power now thrives. Cloud time, in service of security and profit, assumes all is knowable. We bear witness to the collapse of both past and future virtuals into a present dedicated to the exploitation of the spectres of both.

  9. Instability of chromosome number and DNA methylation variation induced by hybridization and amphidiploid formation between Raphanus sativus L. and Brassica alboglabra Bailey

    Directory of Open Access Journals (Sweden)

    Wang Yanjie

    2010-09-01

    Full Text Available Abstract Background Distant hybridization can result genome duplication and allopolyploid formation which may play a significant role in the origin and evolution of many plant species. It is unclear how the two or more divergent genomes coordinate in one nucleus with a single parental cytoplasm within allopolyploids. We used cytological and molecular methods to investigate the genetic and epigenetic instabilities associated with the process of distant hybridization and allopolyploid formation, measuring changes in chromosome number and DNA methylation across multiple generations. Results F1 plants from intergeneric hybridization between Raphanus sativus L. (2n = 18, RR and Brassica alboglabra Bailey (2n = 18, CC were obtained by hand crosses and subsequent embryo rescue. Random amplification of polymorphic DNA (RAPD markers were used to identify the F1 hybrid plants. The RAPD data indicated that the hybrids produced specific bands similar to those of parents and new bands that were not present in either parent. Chromosome number variation of somatic cells from allotetraploids in the F4 to F10 generations showed that intensive genetic changes occurred in the early generations of distant hybridization, leading to the formation of mixopolyploids with different chromosome numbers. DNA methylation variation was revealed using MSAP (methylation-sensitive amplification polymorphism, which showed that cytosine methylation patterns changed markedly in the process of hybridization and amphidiploid formation. Differences in cytosine methylation levels demonstrated an epigenetic instability of the allopolyploid of Raphanobrassica between the genetically stable and unstable generations. Conclusions Our results showed that chromosome instability occurred in the early generations of allopolyploidy and then the plants were reverted to largely euploidy in later generations. During this process, DNA methylation changed markedly. These results suggest that

  10. Elastocapillary Instability in Mitochondrial Fission

    Science.gov (United States)

    Gonzalez-Rodriguez, David; Sart, Sébastien; Babataheri, Avin; Tareste, David; Barakat, Abdul I.; Clanet, Christophe; Husson, Julien

    2015-08-01

    Mitochondria are dynamic cell organelles that constantly undergo fission and fusion events. These dynamical processes, which tightly regulate mitochondrial morphology, are essential for cell physiology. Here we propose an elastocapillary mechanical instability as a mechanism for mitochondrial fission. We experimentally induce mitochondrial fission by rupturing the cell's plasma membrane. We present a stability analysis that successfully explains the observed fission wavelength and the role of mitochondrial morphology in the occurrence of fission events. Our results show that the laws of fluid mechanics can describe mitochondrial morphology and dynamics.

  11. Risk bubbles and market instability

    Science.gov (United States)

    Marsili, Matteo; Raffaelli, Giacomo

    2006-10-01

    We discuss a simple model of correlated assets capturing the feedback effects induced by portfolio investment in the covariance dynamics. This model predicts an instability when the volume of investment exceeds a critical value. Close to the critical point the model exhibits dynamical correlations very similar to those observed in real markets. Maximum likelihood estimates of the model's parameter for empirical data indeed confirms this conclusion. We show that this picture is confirmed by the empirical analysis for different choices of the time horizon.

  12. Delayed chromosomal instability caused by large deletion

    International Nuclear Information System (INIS)

    Ojima, M.; Suzuki, K.; Kodama, S.; Watanabe, M.

    2003-01-01

    Full text: There is accumulating evidence that genomic instability, manifested by the expression of delayed phenotypes, is induced by X-irradiation but not by ultraviolet (UV) light. It is well known that ionizing radiation, such as X-rays, induces DNA double strand breaks, but UV-light mainly causes base damage like pyrimidine dimers and (6-4) photoproducts. Although the mechanism of radiation-induced genomic instability has not been thoroughly explained, it is suggested that DNA double strand breaks contribute the induction of genomic instability. We examined here whether X-ray induced gene deletion at the hprt locus induces delayed instability in chromosome X. SV40-immortalized normal human fibroblasts, GM638, were irradiated with X-rays (3, 6 Gy), and the hprt mutants were isolated in the presence of 6-thioguanine (6-TG). A 2-fold and a 60-fold increase in mutation frequency were found by 3 Gy and 6 Gy irradiation, respectively. The molecular structure of the hprt mutations was determined by multiplex polymerase chain reaction of nine exons. Approximately 60% of 3 Gy mutants lost a part or the entire hprt gene, and the other mutants showed point mutations like spontaneous mutants. All 6 Gy mutants show total gene deletion. The chromosomes of the hprt mutants were analyzed by Whole Human Chromosome X Paint FISH or Xq telomere FISH. None of the point or partial gene deletion mutants showed aberrations of X-chromosome, however total gene deletion mutants induced translocations and dicentrics involving chromosome X. These results suggest that large deletion caused by DNA double strand breaks destabilizes chromosome structure, which may be involved in an induction of radiation-induced genomic instability

  13. Ordinary mode instability associated with thermal ring distribution

    Science.gov (United States)

    Hadi, F.; Yoon, P. H.; Qamar, A.

    2015-02-01

    The purely growing ordinary (O) mode instability driven by excessive parallel temperature anisotropy has recently received renewed attention owing to its potential applicability to the solar wind plasma. Previous studies of O mode instability have assumed either bi-Maxwellian or counter-streaming velocity distributions. For solar wind plasma trapped in magnetic mirror-like geometry such as magnetic clouds or in the vicinity of the Earth's collisionless bow shock environment, however, the velocity distribution function may possess a loss-cone feature. The O-mode instability in such a case may be excited for cyclotron harmonics as well as the purely growing branch. The present paper investigates the O-mode instability for plasmas characterized by the parallel Maxwellian distribution and perpendicular thermal ring velocity distribution in order to understand the general stability characteristics.

  14. Ordinary mode instability associated with thermal ring distribution

    Energy Technology Data Exchange (ETDEWEB)

    Hadi, F.; Qamar, A. [Institute of Physics and Electronics, University of Peshawar, Peshawar 25000 (Pakistan); Yoon, P. H. [Institute for Physical Science and Technology, University of Maryland, College Park, Maryland 20742 (United States); School of Space Research, Kyung Hee University, Yongin-Si, Gyeonggi-Do 446-701 (Korea, Republic of)

    2015-02-15

    The purely growing ordinary (O) mode instability driven by excessive parallel temperature anisotropy has recently received renewed attention owing to its potential applicability to the solar wind plasma. Previous studies of O mode instability have assumed either bi-Maxwellian or counter-streaming velocity distributions. For solar wind plasma trapped in magnetic mirror-like geometry such as magnetic clouds or in the vicinity of the Earth's collisionless bow shock environment, however, the velocity distribution function may possess a loss-cone feature. The O-mode instability in such a case may be excited for cyclotron harmonics as well as the purely growing branch. The present paper investigates the O-mode instability for plasmas characterized by the parallel Maxwellian distribution and perpendicular thermal ring velocity distribution in order to understand the general stability characteristics.

  15. Electron cloud in the CERN accelerator complex

    CERN Document Server

    AUTHOR|(CDS)2069325; Bartosik, Hannes; Belli, Eleonora; Iadarola, Giovanni; Li, Kevin Shing Bruce; Mether, Lotta Maria; Romano, Annalisa; Schenk, Michael

    2016-01-01

    Operation with closely spaced bunched beams causes the build-up of an Electron Cloud (EC) in both the LHC and the two last synchrotrons of its injector chain (PS and SPS). Pressure rise and beam instabilities are observed at the PS during the last stage of preparation of the LHC beams. The SPS was affected by coherent and incoherent emittance growth along the LHC bunch train over many years, before scrubbing has finally suppressed the EC in a large fraction of the machine. When the LHC started regular operation with 50 ns beams in 2011, EC phenomena appeared in the arcs during the early phases, and in the interaction regions with two beams all along the run. Operation with 25 ns beams (late 2012 and 2015), which is nominal for LHC, has been hampered by EC induced high heat load in the cold arcs, bunch dependent emittance growth and degraded beam lifetime. Dedicated and parasitic machine scrubbing is presently the weapon used at the LHC to combat EC in this mode of operation. This talk summarises the EC experi...

  16. Tearing instabilities in turbulence

    International Nuclear Information System (INIS)

    Ishizawa, A.; Nakajima, N.

    2009-01-01

    Full text: Effects of micro-turbulence on tearing instabilities are investigated by numerically solving a reduced set of two-fluid equations. Micro-turbulence excites both large-scale and small-scale Fourier modes through energy transfer due to nonlinear mode coupling. The energy transfer to large scale mode does not directly excite tearing instability but it gives an initiation of tearing instability. When tearing instability starts to grow, the excited small scale mode plays an important role. The mixing of magnetic flux by micro-turbulence is the dominant factor of non-ideal MHD effect at the resonant surface and it gives rise to magnetic reconnection which causes tearing instability. Tearing instabilities were investigated against static equilibrium or flowing equilibrium so far. On the other hand, the recent progress of computer power allows us to investigate interactions between turbulence and coherent modes such as tearing instabilities in magnetically confined plasmas by means of direct numerical simulations. In order to investigate effects of turbulence on tearing instabilities we consider a situation that tearing mode is destabilized in a quasi-equilibrium including micro-turbulence. We choose an initial equilibrium that is unstable against kinetic ballooning modes and tearing instabilities. Tearing instabilities are current driven modes and thus they are unstable for large scale Fourier modes. On the other hand kinetic ballooning modes are unstable for poloidal Fourier modes that are characterized by ion Larmor radius. The energy of kinetic ballooning modes spreads over wave number space through nonlinear Fourier mode coupling. We present that micro-turbulence affects tearing instabilities in two different ways by three-dimensional numerical simulation of a reduced set of two-fluid equations. One is caused by energy transfer to large scale modes, the other is caused by energy transfer to small scale modes. The former is the excitation of initial

  17. Loss of yeast peroxiredoxin Tsa1p induces genome instability through activation of the DNA damage checkpoint and elevation of dNTP levels.

    Directory of Open Access Journals (Sweden)

    Hei-Man Vincent Tang

    2009-10-01

    Full Text Available Peroxiredoxins are a family of antioxidant enzymes critically involved in cellular defense and signaling. Particularly, yeast peroxiredoxin Tsa1p is thought to play a role in the maintenance of genome integrity, but the underlying mechanism is not understood. In this study, we took a genetic approach to investigate the cause of genome instability in tsa1Delta cells. Strong genetic interactions of TSA1 with DNA damage checkpoint components DUN1, SML1, and CRT1 were found when mutant cells were analyzed for either sensitivity to DNA damage or rate of spontaneous base substitutions. An elevation in intracellular dNTP production was observed in tsa1Delta cells. This was associated with constitutive activation of the DNA damage checkpoint as indicated by phosphorylation of Rad9/Rad53p, reduced steady-state amount of Sml1p, and induction of RNR and HUG1 genes. In addition, defects in the DNA damage checkpoint did not modulate intracellular level of reactive oxygen species, but suppressed the mutator phenotype of tsa1Delta cells. On the contrary, overexpression of RNR1 exacerbated this phenotype by increasing dNTP levels. Taken together, our findings uncover a new role of TSA1 in preventing the overproduction of dNTPs, which is a root cause of genome instability.

  18. Essentials of cloud computing

    CERN Document Server

    Chandrasekaran, K

    2014-01-01

    ForewordPrefaceComputing ParadigmsLearning ObjectivesPreambleHigh-Performance ComputingParallel ComputingDistributed ComputingCluster ComputingGrid ComputingCloud ComputingBiocomputingMobile ComputingQuantum ComputingOptical ComputingNanocomputingNetwork ComputingSummaryReview PointsReview QuestionsFurther ReadingCloud Computing FundamentalsLearning ObjectivesPreambleMotivation for Cloud ComputingThe Need for Cloud ComputingDefining Cloud ComputingNIST Definition of Cloud ComputingCloud Computing Is a ServiceCloud Computing Is a Platform5-4-3 Principles of Cloud computingFive Essential Charact

  19. Pressure bump instability in very large cold bore storage rings

    International Nuclear Information System (INIS)

    Limon, P.

    1983-12-01

    Calculations have been done to estimate the circulating current necessary to induce the onset of a pressure bump instability in a cold bore storage ring. For a wide range of storage ring parameters, the instability threshold current is more than an order of magnitude higher than the operating current. 4 references, 2 tables

  20. Isotope separation of uranium by laser: tuning and frequency instability

    International Nuclear Information System (INIS)

    Broglia, M.; Massimi, M.; Spoglia, U.; Zampetti, P.

    1983-01-01

    Intensity measurements of laser induced fluorescence in an uranium atomic beam are affected by the axial mode structure of the commercial pulsed dye laser used and by its strong frequency instability. Qualitative and quantitative evaluations on the possible causes of frequency instability are reported

  1. Character of decay instability

    International Nuclear Information System (INIS)

    Polovin, R.V.; Demutskii, V.P.

    1981-01-01

    If the initial wave is unstable in the upper half plane Im ω>0 and there are no branch points of the quasiwave number, or if waves traveling in the same direction coalesce at a branch point, the instability is convective. On the other hand, if a branch point k(ω) does exist in the upper half-plane Im ω>0, and not all the waves that merge at this point travel in the same direction, the instability is absolute. A Green's function that describes the evolution of the perturbations of the initial wave in space and in time is constructed. The growth rates of the decay instability of the harmonics are determined. The produced waves are richer in harmonics than the initial waves. It is shown that the decay instability of an Alfven wave is absolute

  2. Spondylolisthesis and Posterior Instability

    International Nuclear Information System (INIS)

    Niggemann, P.; Beyer, H.K.; Frey, H.; Grosskurth, D.; Simons, P.; Kuchta, J.

    2009-01-01

    We present the case of a patient with a spondylolisthesis of L5 on S1 due to spondylolysis at the level L5/S1. The vertebral slip was fixed and no anterior instability was found. Using functional magnetic resonance imaging (MRI) in an upright MRI scanner, posterior instability at the level of the spondylolytic defect of L5 was demonstrated. A structure, probably the hypertrophic ligament flava, arising from the spondylolytic defect was displaced toward the L5 nerve root, and a bilateral contact of the displaced structure with the L5 nerve root was shown in extension of the spine. To our knowledge, this is the first case described of posterior instability in patients with spondylolisthesis. The clinical implications of posterior instability are unknown; however, it is thought that this disorder is common and that it can only be diagnosed using upright MRI

  3. Spondylolisthesis and Posterior Instability

    Energy Technology Data Exchange (ETDEWEB)

    Niggemann, P.; Beyer, H.K.; Frey, H.; Grosskurth, D. (Privatpraxis fuer Upright MRT, Koeln (Germany)); Simons, P.; Kuchta, J. (Media Park Klinik, Koeln (Germany))

    2009-04-15

    We present the case of a patient with a spondylolisthesis of L5 on S1 due to spondylolysis at the level L5/S1. The vertebral slip was fixed and no anterior instability was found. Using functional magnetic resonance imaging (MRI) in an upright MRI scanner, posterior instability at the level of the spondylolytic defect of L5 was demonstrated. A structure, probably the hypertrophic ligament flava, arising from the spondylolytic defect was displaced toward the L5 nerve root, and a bilateral contact of the displaced structure with the L5 nerve root was shown in extension of the spine. To our knowledge, this is the first case described of posterior instability in patients with spondylolisthesis. The clinical implications of posterior instability are unknown; however, it is thought that this disorder is common and that it can only be diagnosed using upright MRI.

  4. Streaming gravity mode instability

    International Nuclear Information System (INIS)

    Wang Shui.

    1989-05-01

    In this paper, we study the stability of a current sheet with a sheared flow in a gravitational field which is perpendicular to the magnetic field and plasma flow. This mixing mode caused by a combined role of the sheared flow and gravity is named the streaming gravity mode instability. The conditions of this mode instability are discussed for an ideal four-layer model in the incompressible limit. (author). 5 refs

  5. Induction of genetic instability by ionizing radiation

    International Nuclear Information System (INIS)

    Little, J.B.

    1999-01-01

    Evidence is presented to support the hypothesis that radiation may induce a heritable, genome-wide process of instability that leads to an enhanced frequency of genetic changes occurring among the progeny of the original irradiated cell. This instability is transmissible over many generations of cell replication. Mutational instability is induced in a relatively large fraction (approximately 10 %) of the cell population, and may be modulated by factors acting in vivo. Thus, it cannot be a targeted event involving a specific gene or set of genes. There is no dose-response relationship in the range 2-12 Gy, suggesting that the instability phenotype may be induced by quite low radiation doses. The molecular mechanisms associated with the genesis of mutations in unstable populations differ from those for direct X-ray-induced mutations. These results suggest that it may not be possible to predict the nature of the dose-response relationship for the ultimate genetic effects of radiation based on a qualitative or quantitative analysis of the original DNA lesions. (author)

  6. Simulation of the electron cloud density in BEPC II

    International Nuclear Information System (INIS)

    Liu Yudong; Guo Zhiyuan; Wang Jiuqing

    2004-01-01

    Electron Cloud Instability (ECI) may take place in positron storage ring when the machine is operated with multi-bunch positron beam. According to the actual shape of the vacuum chamber in the BEPC II, a program has been developed. With the code, authors can calculate the electron density in the chamber with different length of antechamber and the different secondary electron yield respectively. By the simulation, the possibility to put clearing electrodes in the chamber to reduce the electron density in the central region of the chamber is investigated. The simulation provides meaningful and important results for the BEPC II project and electron cloud instability research

  7. Cloud Computing, Tieto Cloud Server Model

    OpenAIRE

    Suikkanen, Saara

    2013-01-01

    The purpose of this study is to find out what is cloud computing. To be able to make wise decisions when moving to cloud or considering it, companies need to understand what cloud is consists of. Which model suits best to they company, what should be taken into account before moving to cloud, what is the cloud broker role and also SWOT analysis of cloud? To be able to answer customer requirements and business demands, IT companies should develop and produce new service models. IT house T...

  8. Simulation of electron cloud effects to heavy ion beams

    Energy Technology Data Exchange (ETDEWEB)

    Yaman, Fatih; Gjonaj, Erion; Weiland, Thomas [Technische Universitaet Darmstadt (Germany). Institut fuer Theorie Elektromagnetischer Felder

    2011-07-01

    Electron cloud (EC) driven instability can cause beam loss, emittance growth, trajectory change and wake fields. Mentioned crucial effects of EC motivated researchers to understand the EC build up mechanism and the effects of EC to the beam. This motivation also induced the progress of developing new simulation codes. EC simulations can roughly be divided into two classes such as, softwares whose goals are to simulate the build up of the EC during the passage of a bunch train and the codes which model the interaction of a bunch with an EC. The aim of this study is to simulate the effects of electron cloud (EC) on the dynamics of heavy ion beams which are used in heavy ion synchrotron (SIS-18) at GSI. To do this, a 3-D and self-consistent simulation program based on particle in cell (PIC) method is used. In the PIC cycle, accurate solution of the Maxwell equations is obtained by employing discontinuous Galerkin finite element method. As a model, we assumed a perfectly conducting beam pipe which was uniformly (or randomly) loaded with the electrons. Then as parallel with the realistic cases in SIS-18, a single bunch consisting of U{sup +73} ions was extracted which could propagate in this pipe. Due to EC-ion bunch interaction, electrons gained energy and their displacements were observed. Electric and magnetic field components and EC charge density were calculated, numerically.

  9. Blue skies for CLOUD

    CERN Multimedia

    2006-01-01

    Through the recently approved CLOUD experiment, CERN will soon be contributing to climate research. Tests are being performed on the first prototype of CLOUD, an experiment designed to assess cosmic radiation influence on cloud formation.

  10. Depolarization Lidar Determination of Cloud-Base Microphysical Properties

    NARCIS (Netherlands)

    Donovan, D.P.; Klein Baltink, H; Henzing, J. S.; de Roode, S.R.; Siebesma, A.P.

    2016-01-01

    The links between multiple-scattering induced depolarization and cloud microphysical properties (e.g. cloud particle number density, effective radius, water content) have long been recognised. Previous efforts to use depolarization information in a quantitative manner to retrieve cloud

  11. Transverse two-stream instability in a matched plasma channel

    International Nuclear Information System (INIS)

    Whlttum, D.H.

    1994-01-01

    A relativistic electron beam magnetically self-focused in a plasma is subject to a transverse two stream or 'hose' instability. Linear evolution is described in terms of a tune distribution characterizing the beam, and an effective transverse impedance determined by the beam and the plasma profiles. This model is compared to cloud-in-cell simulations of three-dimensional transport of a beam with a Bennett profile, through a matched plasma channel. In the limit of large skin-depth this instability appears to be the primary limitation on stable beam transport. (author)

  12. Moving towards Cloud Security

    OpenAIRE

    Edit Szilvia Rubóczki; Zoltán Rajnai

    2015-01-01

    Cloud computing hosts and delivers many different services via Internet. There are a lot of reasons why people opt for using cloud resources. Cloud development is increasing fast while a lot of related services drop behind, for example the mass awareness of cloud security. However the new generation upload videos and pictures without reason to a cloud storage, but only few know about data privacy, data management and the proprietary of stored data in the cloud. In an enterprise environment th...

  13. In vitro short-term exposure to air pollution PM{sub 2.5-0.3} induced cell cycle alterations and genetic instability in a human lung cell coculture model

    Energy Technology Data Exchange (ETDEWEB)

    Abbas, Imane [Université de Lille, Lille (France); EA4492-UCEIV, Université du Littoral-Côte d’Opale, Dunkerque (France); Lebanese Atomic Energy Commission – CNRS, Beirut (Lebanon); Verdin, Anthony [Université de Lille, Lille (France); EA4492-UCEIV, Université du Littoral-Côte d’Opale, Dunkerque (France); Escande, Fabienne [Centre de Biologie Pathologie, Centre Hospitalier Régional et Universitaire, Lille (France); Saint-Georges, Françoise [Université de Lille, Lille (France); Groupement Hospitalier de l’Institut Catholique de Lille, Lille (France); Cazier, Fabrice [Université de Lille, Lille (France); Centre Commun de Mesures, Université du Littoral-Côte d’Opale, Dunkerque (France); Mulliez, Philippe [Université de Lille, Lille (France); Groupement Hospitalier de l’Institut Catholique de Lille, Lille (France); Courcot, Dominique; Shirali, Pirouz [Université de Lille, Lille (France); EA4492-UCEIV, Université du Littoral-Côte d’Opale, Dunkerque (France); Gosset, Pierre [Université de Lille, Lille (France); Groupement Hospitalier de l’Institut Catholique de Lille, Lille (France); and others

    2016-05-15

    Although its adverse health effects of air pollution particulate matter (PM2.5) are well-documented and often related to oxidative stress and pro-inflammatory response, recent evidence support the role of the remodeling of the airway epithelium involving the regulation of cell death processes. Hence, the overarching goals of the present study were to use an in vitro coculture model, based on human AM and L132 cells to study the possible alteration of TP53-RB gene signaling pathways (i.e. cell cycle phases, gene expression of TP53, BCL2, BAX, P21, CCND1, and RB, and protein concentrations of their active forms), and genetic instability (i.e. LOH and/or MSI) in the PM{sub 2.5-0.3}-exposed coculture model. PM{sub 2.5-0.3} exposure of human AM from the coculture model induced marked cell cycle alterations after 24 h, as shown by increased numbers of L132 cells in subG1 and S+G2 cell cycle phases, indicating apoptosis and proliferation. Accordingly, activation of the TP53-RB gene signaling pathways after the coculture model exposure to PM{sub 2.5-0.3} was reported in the L132 cells. Exposure of human AM from the coculture model to PM{sub 2.5-0.3} resulted in MS alterations in 3p chromosome multiple critical regions in L132 cell population. Hence, in vitro short-term exposure of the coculture model to PM{sub 2.5-0.3} induced cell cycle alterations relying on the sequential occurrence of molecular abnormalities from TP53-RB gene signaling pathway activation and genetic instability. - Highlights: • Better knowledge on health adverse effects of air pollution PM{sub 2.5}. • Human alveolar macrophage and normal human epithelial lung cell coculture. • Molecular abnormalities from TP53-RB gene signaling pathway. • Loss of heterozygosity and microsatellite instability. • Pathologic changes in morphology and number of cells in relation to airway remodeling.

  14. STRUCTURAL STRESS RELAXATION IN STAINLESS INSTABILITY STEEL

    Directory of Open Access Journals (Sweden)

    S. Lyabuk

    2017-06-01

    Full Text Available The approach to the description of conditions of martensitic transformation in austenitic steel is advanced. Transformation induced hardening is the result of Le Chatelier principle in instability alloys. The phase transformation in austenitic instability stainless steel is the cause of reduction of grain refining and increase of strength. It was experimentally shown that physical-mechanical characteristics of the prepared materials were defined by the structure and inhomogeneous distribution of the hardening phase within a grain. The reasons for high thermal stability of inverse austenitic were established. The factors determining the inverse austenitic relaxation resistibility and resources for its increasing were revealed.

  15. Composition driven structural instability in perovskite ferroelectrics

    Directory of Open Access Journals (Sweden)

    Chao Xu

    2017-04-01

    Full Text Available Ferroelectric solid solutions usually exhibit enhanced functional properties at the morphotropic phase boundary separating two ferroelectric phases with different orientations of polarization. The underlying mechanism is generally associated with polarization rotational instability and the flattened free energy profile. In this work we show that the polarization extensional instability can also be induced at the morphotropic phase boundary beyond the reported polar-nonpolar phase boundary. The piezoelectricity enhanced by this mechanism exhibits excellent thermal stability, which helps to develop high performance piezoelectric materials with good temperature stability.

  16. Pulsating instabilities and chaos in lasers

    Energy Technology Data Exchange (ETDEWEB)

    Harrison, R G; Biswas, D J

    1985-01-01

    A detailed state of the art survey of deterministic chaos in laser systems is presented. The mechanism of single mode instability is discussed, including spontaneous and induced mode splitting and the threshold for laser instabilities. Single mode homogeneously broadened systems are addressed, including optically pumped far infrared lasers and near-resonantly pumped midinfrared systems. Single mode inhomogeneously broadened systems are considered, including the He-Xe laser and the He-Ne laser at 3.39 microns. Single mode lasers with external control parameter are discussed, as is the multimode laser. 297 references.

  17. Anisotropic instability in a laser heated plasma

    International Nuclear Information System (INIS)

    Sangam, A.; Morreeuw, J.-P.; Tikhonchuk, V. T.

    2007-01-01

    The theory of the Weibel instability induced by the inverse Bremsstrahlung absorption of a laser light in an underdense plasma is revisited. It is shown that previous analyses have strongly overestimated the effect by neglecting the stabilizing term related to the interaction of the generated quasistatic magnetic field with the laser-heated electrons. The revised model leads to a reduction of the growth rate by more than a factor of 10, to strong reduction of the domain of unstable modes and to inversion of the direction of the unstable wave vectors in the long wavelength limit. The consequences of this instability on the laser plasma interaction are also discussed

  18. Cloud Infrastructure & Applications - CloudIA

    Science.gov (United States)

    Sulistio, Anthony; Reich, Christoph; Doelitzscher, Frank

    The idea behind Cloud Computing is to deliver Infrastructure-as-a-Services and Software-as-a-Service over the Internet on an easy pay-per-use business model. To harness the potentials of Cloud Computing for e-Learning and research purposes, and to small- and medium-sized enterprises, the Hochschule Furtwangen University establishes a new project, called Cloud Infrastructure & Applications (CloudIA). The CloudIA project is a market-oriented cloud infrastructure that leverages different virtualization technologies, by supporting Service-Level Agreements for various service offerings. This paper describes the CloudIA project in details and mentions our early experiences in building a private cloud using an existing infrastructure.

  19. Fiber amplifiers under thermal loads leading to transverse mode instability

    DEFF Research Database (Denmark)

    Johansen, Mette Marie; Hansen, Kristian Rymann; Alkeskjold, Thomas Tanggaard

    2014-01-01

    Transverse mode instability (TMI) in rare-earth doped fiber amplifiers operating above an average power threshold is caused by intermodal stimulated thermal Rayleigh scattering due to quantum defect heating. We investigate thermally induced longitudinal waveguide perturbations causing power...

  20. Control of transversal instabilities in reaction-diffusion systems

    Science.gov (United States)

    Totz, Sonja; Löber, Jakob; Totz, Jan Frederik; Engel, Harald

    2018-05-01

    In two-dimensional reaction-diffusion systems, local curvature perturbations on traveling waves are typically damped out and vanish. However, if the inhibitor diffuses much faster than the activator, transversal instabilities can arise, leading from flat to folded, spatio-temporally modulated waves and to spreading spiral turbulence. Here, we propose a scheme to induce or inhibit these instabilities via a spatio-temporal feedback loop. In a piecewise-linear version of the FitzHugh–Nagumo model, transversal instabilities and spiral turbulence in the uncontrolled system are shown to be suppressed in the presence of control, thereby stabilizing plane wave propagation. Conversely, in numerical simulations with the modified Oregonator model for the photosensitive Belousov–Zhabotinsky reaction, which does not exhibit transversal instabilities on its own, we demonstrate the feasibility of inducing transversal instabilities and study the emerging wave patterns in a well-controlled manner.

  1. Silicon Photonics Cloud (SiCloud)

    DEFF Research Database (Denmark)

    DeVore, P. T. S.; Jiang, Y.; Lynch, M.

    2015-01-01

    Silicon Photonics Cloud (SiCloud.org) is the first silicon photonics interactive web tool. Here we report new features of this tool including mode propagation parameters and mode distribution galleries for user specified waveguide dimensions and wavelengths.......Silicon Photonics Cloud (SiCloud.org) is the first silicon photonics interactive web tool. Here we report new features of this tool including mode propagation parameters and mode distribution galleries for user specified waveguide dimensions and wavelengths....

  2. Plasma physics and instabilities

    International Nuclear Information System (INIS)

    Lashmore-Davies, C.N.

    1981-01-01

    These lectures procide an introduction to the theory of plasmas and their instabilities. Starting from the Bogoliubov, Born, Green, Kirkwood, and Yvon (BBGKY) hierarchy of kinetic equations, the additional concept of self-consistent fields leads to the fundamental Vlasov equation and hence to the warm two-fluid model and the one-fluid MHD, or cold, model. The properties of small-amplitude waves in magnetized (and unmagnetized) plasmas, and the instabilities to which they give rise, are described in some detail, and a complete chapter is devoted to Landau damping. The linear theory of plasma instabilities is illustrated by the current-driven electrostatic kind, with descriptions of the Penrose criterion and the energy principle of ideal MHD. There is a brief account of the application of feedback control. The non-linear theory is represented by three examples: quasi-linear velocity-space instabilities, three-wave instabilities, and the stability of an arbitrarily largeamplitude wave in a plasma. (orig.)

  3. A general theory for dynamic instability of tube arrays in crossflow

    Science.gov (United States)

    Chen, S. S.

    1987-01-01

    A general theory of fluidelastic instability for a tube array in crossflow is presented. Various techniques to obtain the motion-dependent fluid-force coefficients are discussed and the general instability characteristics are summarized. The theory is also used to evaluate the results of other mathematical models for crossflow-induced instability.

  4. Neutrino signal from pair-instability supernovae

    Science.gov (United States)

    Wright, Warren P.; Gilmer, Matthew S.; Fröhlich, Carla; Kneller, James P.

    2017-11-01

    A very massive star with a carbon-oxygen core in the range of 64M ⊙Earth from two, one-dimensional pair-instability supernova simulations which bracket the mass range of stars which explode by this mechanism taking into account the full time and energy dependence of the neutrino emission and the flavor evolution through the outer layers of the star. We calculate the neutrino signals in five different detectors chosen to represent present or near future designs. We find the more massive progenitors explode as pair-instability supernova which can easily be detected in multiple different neutrino detectors at the "standard" supernova distance of 10 kpc producing several events in DUNE, JUNO, and Super-Kamiokande, while the lightest progenitors produce only a handful of events (if any) in the same detectors. The proposed Hyper-Kamiokande detector would detect neutrinos from a large pair-instability supernova as far as ˜50 kpc allowing it to reach the Megallanic Clouds and the several very high mass stars known to exist there.

  5. Interstellar clouds and the formation of stars

    International Nuclear Information System (INIS)

    Alfen, H.; Carlqvist, P.

    1977-12-01

    The 'pseudo-plasma formalism' which up to now has almost completely dominated theoretical astrophysics must be replaced by an experimentally based approach, involving the introduction of a number of neglected plasma phenomena, such as electric double layers, critical velocity, and pinch effect. The general belief that star light is the main ionizer is shown to be doubtful; hydromagnetic conversion of gravitational and kinetic energy may often be much more important. The revised plasma physics is applied to dark clouds and star formation. Magnetic fields do not necessarily counteract the contraction of a cloud, they may just as well 'pinch' the cloud. Magnetic compression may be the main mechanism for forming interstellar clouds and keeping them together. Star formation is due to an instability, but it is very unlikely that it has anything to do with the Jeans instablility. A reasonable mechanism is that the sedimentation of 'dust' (including solid bodies of different size) is triggering off a gravitationally assisted accretion. The study of the evolution of a dark cloud leads to a scenario of planet formation which is reconcilable with the results obtained from studies based on solar system data. This means that the new approach to cosmical plasma physics discussed logically leads to a consistent picture of the evolution of dark clouds and the formation of solar systems

  6. New photoionization models of intergalactic clouds

    Science.gov (United States)

    Donahue, Megan; Shull, J. M.

    1991-01-01

    New photoionization models of optically thin low-density intergalactic gas at constant pressure, photoionized by QSOs, are presented. All ion stages of H, He, C, N, O, Si, and Fe, plus H2 are modeled, and the column density ratios of clouds at specified values of the ionization parameter of n sub gamma/n sub H and cloud metallicity are predicted. If Ly-alpha clouds are much cooler than the previously assumed value, 30,000 K, the ionization parameter must be very low, even with the cooling contribution of a trace component of molecules. If the clouds cool below 6000 K, their final equilibrium must be below 3000 K, owing to the lack of a stable phase between 6000 and 3000 K. If it is assumed that the clouds are being irradiated by an EUV power-law continuum typical of WSOs, with J0 = 10 exp -21 ergs/s sq cm Hz, typical cloud thicknesses along the line of sight that are much smaller than would be expected from shocks, thermal instabilities, or gravitational collapse are derived.

  7. Dynamics and Instabilities of Vortex Pairs

    Science.gov (United States)

    Leweke, Thomas; Le Dizès, Stéphane; Williamson, Charles H. K.

    2016-01-01

    This article reviews the characteristics and behavior of counter-rotating and corotating vortex pairs, which are seemingly simple flow configurations yet immensely rich in phenomena. Since the reviews in this journal by Widnall (1975) and Spalart (1998) , who studied the fundamental structure and dynamics of vortices and airplane trailing vortices, respectively, there have been many analytical, computational, and experimental studies of vortex pair flows. We discuss two-dimensional dynamics, including the merging of same-sign vortices and the interaction with the mutually induced strain, as well as three-dimensional displacement and core instabilities resulting from this interaction. Flows subject to combined instabilities are also considered, in particular the impingement of opposite-sign vortices on a ground plane. We emphasize the physical mechanisms responsible for the flow phenomena and clearly present the key results that are useful to the reader for predicting the dynamics and instabilities of parallel vortices.

  8. Microwave instability across the transition energy

    International Nuclear Information System (INIS)

    Lee, S.Y.; Wang, J.M.

    1985-01-01

    It is well known that during the acceleration of hadrons in a storage ring, the beam always goes above the microwave instability threshold near the transition energy γ /SUB t/ . The reason is that the longitudinal revolution frequency spread of the beam which otherwise provides Landau damping vanishes at the transition energy. The amount of the beam dilution near the transition energy is determined by /tau/ /SUB th/ , the length of time when the beam stays unstable, and the growth rate of the instability. It is pointed out in this paper that /tau/ /SUB th/ is proportional to the fourth power of γ /SUB t/ , and thus the choice of a large γ /SUB t/ is not desirable from this point of view. An analysis is also given of the microwave instability induced beam dilution for the proposed Relativistic Heavy Ion Collider at BNL

  9. Microwave instability across the transition energy

    International Nuclear Information System (INIS)

    Lee, S.Y.; Wang, J.M.

    1985-01-01

    It is well known that during the acceleration of hadrons in a storage ring, the beam always goes above the microwave instability threshold near the transition energy γ/sub t/. The reason is that the longitudinal revolution frequency spread of the beam which otherwise provides Landau damping vanishes at the transition energy. The amount of the beam dilution near the transition energy is determined by tau/sub th/, the length of time when the beam stays unstable, and the growth rate of the instability. It is pointed out in this paper that tau/sub th/ is proportional to the fourth power of γ/sub t/, and thus the choice of a large γ/sub t/ is not desirable from this point of view. An analysis is also given of the microwave instability induced beam dilution for the proposed Relativistic Heavy Ion Collider at BNL

  10. IN-SITU MONITORING OF INFILTRATION-INDUCED INSTABILITY OF I-70 EMBANKMENT WEST OF THE EISENHOWER-JOHNSON MEMORIAL TUNNELS, PHASE II

    Science.gov (United States)

    2017-12-25

    Infiltration-induced landslides are common hazards to roads in Colorado. A new methodology that uses recent advances in unsaturated soil mechanics and hydrology was developed and tested. The approach consists on using soil suction and moisture conten...

  11. Turbulence in molecular clouds - A new diagnostic tool to probe their origin

    Science.gov (United States)

    Canuto, V. M.; Battaglia, A.

    1985-01-01

    A method is presented to uncover the instability responsible for the type of turbulence observed in molecular clouds and the value of the physical parameters of the 'placental medium' from which turbulence originated. The method utilizes the observational relation between velocities and sizes of molecular clouds, together with a recent model for large-scale turbulence (constructed by Canuto and Goldman, 1985).

  12. Fingerprints of dynamical instabilities

    International Nuclear Information System (INIS)

    Chomaz, Ph.; Colonna, M.; Guarnera, A.

    1993-01-01

    It is explained why any reduced descriptions, such as mean field approximation, are stochastic in nature. It is shown that the introduction of this stochastic dynamics leads to a predictive theory in a statistical sens whatever the individual trajectories are characterized by the occurrence of bifurcations, instabilities or phase transitions. Concerning nuclear matter, the spinodal instability is discussed. In such a critical situation, the possibility to replace the stochastic part of the collision integral in the Boltzmann-Langevin model by the numerical noise associated with the finite number of test particles in ordinary BUU treatment is studied. It is shown that the fingerprints of these instabilities are kept during the evolution because of the relatively long recombination time compared with the typical time scales imposed by the Coulomb repulsion and the possible collective expansion. (author) 5 refs., 12 figs

  13. Instability and star evolution

    International Nuclear Information System (INIS)

    Mirzoyan, L.V.

    1981-01-01

    The observational data are discussed which testify that the phenomena of dynamical instability of stars and stellar systems are definite manifestations of their evolution. The study of these phenomena has shown that the instability is a regular phase of stellar evolution. It has resulted in the recognition of the most important regularities of the process of star formation concerning its nature. This became possible due to the discovery in 1947 of stellar associations in our Galaxy. The results of the study of the dynamical instability of stellar associations contradict the predictions of classical hypothesis of stellar condensation. These data supplied a basis for a new hypothesis on the formation of stars and nebulae by the decay of superdense protostars [ru

  14. Plastic Instabilities Induced by the Portevin - Le Châtelier Effect and Fracture Character of Deformed Mg-Li Alloys Investigated Using the Acoustic Emission Method

    Directory of Open Access Journals (Sweden)

    Pawełek A.

    2016-06-01

    Full Text Available The results of the investigation of both mechanical and acoustic emission (AE behaviors of Mg4Li5Al and Mg4Li4Zn alloys subjected to compression and tensile tests at room temperature are compared with the test results obtained using the same alloys and loading scheme but at elevated temperatures. The main aim of the paper is to investigate, to determine and to explain the relation between plastic flow instabilities and the fracture characteristics. There are discussed the possible influence of the factors related with enhanced internal stresses such as: segregation of precipitates along grain boundaries, interaction of solute atoms with mobile dislocations (Cottrell atmospheres as well as dislocation pile-ups which may lead to the microcracks formation due to the creation of very high stress concentration at grain boundaries. The results show that the plastic flow discontinuities are related to the Portevin-Le Châtelier phenomenon (PL effect and they are correlated with the generation of characteristic AE pulse trains. The fractography of broken samples was analyzed on the basis of light (optical, TEM and SEM images.

  15. Influence of velocity shear on the Rayleigh-Taylor instability

    International Nuclear Information System (INIS)

    Guzdar, P.N.; Satyanarayana, P.; Huba, J.D.; Ossakow, S.L.

    1982-01-01

    The influence of a transverse velocity shear on the Rayleigh-Taylor instability is investigated. It is found that a sheared velocity flow can substantially reduce the growth rate of the Rayleigh-Taylor instability in short wavelength regime (i.e., kL>1 where L is the scale length of the density inhomogeneity), and causes the growth rate to maximize at kL<1.0. Applications of this result to ionospheric phenomena [equatorial spread F (ESF) and ionospheric plasma clouds] are discussed. In particular, the effect of shear could account for, at times, the 100's of km modulation observed on the bottomside of the ESF ionosphere and the km scale size wavelengths observed in barium cloud prompt striation phenomena

  16. Instabilities and nonequilibrium structures

    International Nuclear Information System (INIS)

    Tirapegui, E.; Villarroel, D.

    1987-01-01

    Physical systems can be studied both near to and far from equilibrium where instabilities appear. The behaviour in these two regions is reviewed in this book, from both the theoretical and application points of view. The influence of noise in these situations is an essential feature which cannot be ignored. It is therefore discussed using phenomenological and theoretical approaches for the numerous problems which still remain in the field. This volume should appeal to mathematicians and physicists interested in the areas of instability, bifurcation theory, dynamical systems, pattern formation, nonequilibrium structures and statistical mechanics. (Auth.)

  17. RINGED ACCRETION DISKS: INSTABILITIES

    Energy Technology Data Exchange (ETDEWEB)

    Pugliese, D.; Stuchlík, Z., E-mail: d.pugliese.physics@gmail.com, E-mail: zdenek.stuchlik@physics.cz [Institute of Physics and Research Centre of Theoretical Physics and Astrophysics, Faculty of Philosophy and Science, Silesian University in Opava, Bezručovo náměstí 13, CZ-74601 Opava (Czech Republic)

    2016-04-01

    We analyze the possibility that several instability points may be formed, due to the Paczyński mechanism of violation of mechanical equilibrium, in the orbiting matter around a supermassive Kerr black hole. We consider a recently proposed model of a ringed accretion disk, made up by several tori (rings) that can be corotating or counter-rotating relative to the Kerr attractor due to the history of the accretion process. Each torus is governed by the general relativistic hydrodynamic Boyer condition of equilibrium configurations of rotating perfect fluids. We prove that the number of the instability points is generally limited and depends on the dimensionless spin of the rotating attractor.

  18. ELECTRON CLOUD EFFECTS IN HIGH INTENSITY PROTON ACCELERATORS

    International Nuclear Information System (INIS)

    Wei, J.; Macek, R.J.

    2002-01-01

    One of the primary concerns in the design and operation of high-intensity proton synchrotrons and accumulators is the electron cloud and associated beam loss and instabilities. Electron-cloud effects are observed at high-intensity proton machines like the Los Alamos National Laboratory's PSR and CERN's SPS, and investigated experimentally and theoretically. In the design of next-generation high-intensity proton accelerators like the Spallation Neutron Source ring, emphasis is made in minimizing electron production and in enhancing Landau damping. This paper reviews the present understanding of the electron-cloud effects and presents mitigation measures

  19. ELECTRON CLOUD EFFECTS IN HIGH INTENSITY PROTON ACCELERATORS.

    Energy Technology Data Exchange (ETDEWEB)

    WEI,J.; MACEK,R.J.

    2002-04-14

    One of the primary concerns in the design and operation of high-intensity proton synchrotrons and accumulators is the electron cloud and associated beam loss and instabilities. Electron-cloud effects are observed at high-intensity proton machines like the Los Alamos National Laboratory's PSR and CERN's SPS, and investigated experimentally and theoretically. In the design of next-generation high-intensity proton accelerators like the Spallation Neutron Source ring, emphasis is made in minimizing electron production and in enhancing Landau damping. This paper reviews the present understanding of the electron-cloud effects and presents mitigation measures.

  20. Theoretical analysis of mode instability in high-power fiber amplifiers

    DEFF Research Database (Denmark)

    Hansen, Kristian Rymann; Alkeskjold, Thomas Tanggaard; Broeng, Jes

    2013-01-01

    We present a simple theoretical model of transverse mode instability in high-power rare-earth doped fiber amplifiers. The model shows that efficient power transfer between the fundamental and higher-order modes of the fiber can be induced by a nonlinear interaction mediated through the thermo......-optic effect, leading to transverse mode instability. The temporal and spectral characteristics of the instability dynamics are investigated, and it is shown that the instability can be seeded by both quantum noise and signal intensity noise, while pure phase noise of the signal does not induce instability...

  1. Gravitational instability in a primordial collapsing gas cloud

    International Nuclear Information System (INIS)

    Lacey, C.G.

    1989-01-01

    This paper presents an analysis of the linear evolution of short-wavelength perturbations in a background fluid flow which is undergoing gravitational collapse on large scales. Local evolution equations for perturbations to an arbitrary flow are derived in the linear regime and the short-wavelength limit. Local perturbation behavior in an inhomogeneous flow is found to be the same as that in a homogeneous anisotropic flow having the same local velocity field. Background flows in which the scale factors vary as power laws in time are considered to illustrate the relative effects of self-gravity, pressure and kinematics of the background flow on the density perturbation evolution. Perturbation analyses are then presented for more realistic background flows arising from the evolution into the nonlinear regime of initially small density perturbations in an isotropically expanding cosmological model. For low-pressure, inhomogeneous collapses, kinematic effects tend to dominate over self-gravity in driving perturbation growth as the collapse proceeds. 28 references

  2. A cloud climatology of the Southern Great Plains ARM CART

    Energy Technology Data Exchange (ETDEWEB)

    Lazarus, S.M.; Krueger, S.K.; Mace, G.G.

    2000-05-15

    Cloud amount statistics from three different sources were processed and compared. Surface observations from a National Centers for Environmental Prediction dataset were used. The data (Edited Cloud Report; ECR) consist of synoptic weather reports that have been edited to facilitate cloud analysis. Two stations near the Southern Great Plains (SGP) Cloud and Radiation Test Bed (CART) in north-central Oklahoma (Oklahoma City, Oklahoma and Wichita, Kansas) were selected. The ECR data span a 10-yr period from December 1981 to November 1991. The International Satellite Cloud Climatology Project (ISCCP) provided cloud amounts over the SGP CART for an 8-yr period (1983--91). Cloud amounts were also obtained from Micro Pulse Lidar (MPL) and Belfort Ceilometer (BLC) cloud-base height measurements made at the SGP CART over a 1-yr period. The annual and diurnal cycles of cloud amount as a function of cloud height and type were analyzed. The three datasets closely agree for total cloud amount. Good agreement was found in the ECR and MPL-BLC monthly low cloud amounts. With the exception of summer and midday in other seasons, the ISCCP low cloud amount estimates are generally 5%--10% less than the others. The ECR high cloud amount estimates are typically 10%--15% greater than those obtained from either the ISCCP or MPL-BLC datasets. The observed diurnal variations of altocumulus support the authors' model results of radiatively induced circulations.

  3. Modulation of precipitation by conditional symmetric instability release

    OpenAIRE

    Glinton, Michael R.; Gray, Suzanne L.; Chagnon, Jeffrey M.; Morcrette, Cyril J.

    2017-01-01

    Although many theoretical and observational studies have investigated the mechanism of conditional symmetric instability (CSI) release and associated it with mesoscale atmospheric phenomena such as frontal precipitation bands, cloud heads in rapidly developing extratropical cyclones and sting jets, its climatology and contribution to precipitation have not been extensively documented. The aim of this paper is to quantify the contribution of CSI release, yielding slantwise convection, to clima...

  4. Radiation-induced genetic instability: no association with changes in radiosensitivity or cell cycle checkpoints in C3H 10T1/2 mouse fibroblasts

    International Nuclear Information System (INIS)

    Crompton, N.E.A.; Emery, G.C.; Shi Yuquan; Sigg, M.; Blattmann, H.

    1998-01-01

    We investigated various phenotypic characteristics of radiation-induced morphologically transformed C3H 10T1/2 mouse fibroblasts. The cells were treated with 8 Gy x-rays, and type II/III foci were isolated. Cell lines were developed from these foci, and subsequently clones were established from these focal lines. The clones were examined for DNA content, radiosensitivity and inducible cell cycle arrests. Besides the morphological changes associated with the transformed state, the major difference between the isolated focal lines or derived clones and the parental C3H 10T1/2 line was one of ploidy. The transformed cells often displayed aneuploid and multiple polyploid populations. No change in the radiosensitivity of the transformed cells was observed. Furthermore, the two major radiation- and staurosporine-induced G1 and G2 cell cycle arrests observed in the parental cell line were also observed in the morphological transformants, suggesting that checkpoint function was normal. (orig.)

  5. Non-linear Q-clouds around Kerr black holes

    International Nuclear Information System (INIS)

    Herdeiro, Carlos; Radu, Eugen; Rúnarsson, Helgi

    2014-01-01

    Q-balls are regular extended ‘objects’ that exist for some non-gravitating, self-interacting, scalar field theories with a global, continuous, internal symmetry, on Minkowski spacetime. Here, analogous objects are also shown to exist around rotating (Kerr) black holes, as non-linear bound states of a test scalar field. We dub such configurations Q-clouds. We focus on a complex massive scalar field with quartic plus hexic self-interactions. Without the self-interactions, linear clouds have been shown to exist, in synchronous rotation with the black hole horizon, along 1-dimensional subspaces – existence lines – of the Kerr 2-dimensional parameter space. They are zero modes of the superradiant instability. Non-linear Q-clouds, on the other hand, are also in synchronous rotation with the black hole horizon; but they exist on a 2-dimensional subspace, delimited by a minimal horizon angular velocity and by an appropriate existence line, wherein the non-linear terms become irrelevant and the Q-cloud reduces to a linear cloud. Thus, Q-clouds provide an example of scalar bound states around Kerr black holes which, generically, are not zero modes of the superradiant instability. We describe some physical properties of Q-clouds, whose backreaction leads to a new family of hairy black holes, continuously connected to the Kerr family

  6. Evidence of a genetic instability induced by the incorporation of a DNA precursor marked with tritium; Mise en evidence d'une instabilite genetique induite par l'incorporation d'un precurseur de L'ADN marque au tritium

    Energy Technology Data Exchange (ETDEWEB)

    Saintigny, Y.; Laurent, D.; Lahayel, J.B. [CEA Fontenay-aux-Roses, IRCM-LRTS, U967 - CEA/INSERM/Universites Paris 7 and Paris-11, 92 (France); Roche, St.; Meynard, D.; Lopez, B.S. [CEA Fontenay-aux-Roses, LMR - UMR 217 - CEA/CNRS, Institut de Radiobiologie Cellulaire et moleculaire, Direction des Sciences du Vivant, 92 (France)

    2009-07-01

    The authors report a molecular geno-toxicology investigation which allowed molecular events induced par intracellular incorporation of tritium to be studied, and the genetic instability resulting from a chronic exposure even at low dose to be analysed. For this purpose, they developed cell models (hamster tumorous cells and human fibroblasts) in which they know how to incorporate given quantities of marked nucleotides in the DNA. They show that the incorporation of tritium, even with doses which are said to be non toxic, causes a prolonged exposure of the cell to a genotoxic stress, and maybe a genetic instability due to a too great number of recombination events

  7. Elbow joint instability

    DEFF Research Database (Denmark)

    Olsen, Bo Sanderhoff; Henriksen, M G; Søjbjerg, Jens Ole

    1994-01-01

    The effect of simultaneous ulnar and radial collateral ligament division on the kinematics of the elbow joint is studied in a cadaveric model. Severance of the anterior part of the ulnar collateral ligament and the annular ligament led to significant elbow joint instability in valgus and varus...

  8. Structural and Material Instability

    DEFF Research Database (Denmark)

    Cifuentes, Gustavo Cifuentes

    This work is a small contribution to the general problem of structural and material instability. In this work, the main subject is the analysis of cracking and failure of structural elements made from quasi-brittle materials like concrete. The analysis is made using the finite element method. Three...

  9. Agricultural Markets Instability

    NARCIS (Netherlands)

    Garrido, A.; Brümmer, B.; M'Barek, R.; Gielen-Meuwissen, M.P.M.; Morales-Opazo, C.

    2016-01-01

    Since the financial and food price crises of 2007, market instability has been a topic of major concern to agricultural economists and policy professionals. This volume provides an overview of the key issues surrounding food prices volatility, focusing primarily on drivers, long-term implications of

  10. Comment on critical instability

    International Nuclear Information System (INIS)

    King, S.F.; Suzuki, Mahiko

    1992-01-01

    We discuss the problem of the mass splitting between top and bottom quarks, within the context of Nambu-Jona-Lasinio type models involving top and bottom quark condensates. We interpret the phenomenon of 'critical instability' recently proposed to account for such a mass splitting as the fine-tuning of two vacuum expectation values in a composite two-Higgs doublet model. (orig.)

  11. BUSINESS INTELLIGENCE IN CLOUD

    OpenAIRE

    Celina M. Olszak

    2014-01-01

    . The paper reviews and critiques current research on Business Intelligence (BI) in cloud. This review highlights that organizations face various challenges using BI cloud. The research objectives for this study are a conceptualization of the BI cloud issue, as well as an investigation of some benefits and risks from BI cloud. The study was based mainly on a critical analysis of literature and some reports on BI cloud using. The results of this research can be used by IT and business leaders ...

  12. Cloud Robotics Platforms

    Directory of Open Access Journals (Sweden)

    Busra Koken

    2015-01-01

    Full Text Available Cloud robotics is a rapidly evolving field that allows robots to offload computation-intensive and storage-intensive jobs into the cloud. Robots are limited in terms of computational capacity, memory and storage. Cloud provides unlimited computation power, memory, storage and especially collaboration opportunity. Cloud-enabled robots are divided into two categories as standalone and networked robots. This article surveys cloud robotic platforms, standalone and networked robotic works such as grasping, simultaneous localization and mapping (SLAM and monitoring.

  13. Formation of massive clouds and dwarf galaxies during tidal encounters

    Science.gov (United States)

    Kaufman, Michele; Elmegreen, Bruce G.; Thomasson, Magnus; Elmegreen, Debra M.

    1993-01-01

    Gerola et al. (1983) propose that isolated dwarf galaxies can form during galaxy interactions. As evidence of this process, Mirabel et al. (1991) find 10(exp 9) solar mass clouds and star formation complexes at the outer ends of the tidal arms in the Antennae and Superantennae galaxies. We describe observations of HI clouds with mass greater than 10(exp 8) solar mass in the interacting galaxy pair IC 2163/NGC 2207. This pair is important because we believe it represents an early stage in the formation of giant clouds during an encounter. We use a gravitational instability model to explain why the observed clouds are so massive and discuss a two-dimensional N-body simulation of an encounter that produces giant clouds.

  14. Electron Cloud Measurements in Fermilab Main Injector and Recycler

    Energy Technology Data Exchange (ETDEWEB)

    Eldred, Jeffrey Scott [Indiana U.; Backfish, M. [Fermilab; Tan, C. Y. [Fermilab; Zwaska, R. [Fermilab

    2015-06-01

    This conference paper presents a series of electron cloud measurements in the Fermilab Main Injector and Recycler. A new instability was observed in the Recycler in July 2014 that generates a fast transverse excitation in the first high intensity batch to be injected. Microwave measurements of electron cloud in the Recycler show a corresponding depen- dence on the batch injection pattern. These electron cloud measurements are compared to those made with a retard- ing field analyzer (RFA) installed in a field-free region of the Recycler in November. RFAs are also used in the Main Injector to evaluate the performance of beampipe coatings for the mitigation of electron cloud. Contamination from an unexpected vacuum leak revealed a potential vulnerability in the amorphous carbon beampipe coating. The diamond-like carbon coating, in contrast, reduced the electron cloud signal to 1% of that measured in uncoated stainless steel beampipe.

  15. On the conventive instability evolution in a rotating gas disk

    International Nuclear Information System (INIS)

    Nikonov, S.V.; Solov'ev, L.S.

    1986-01-01

    The mechanism of formation of spiral configuration in a rotating gravitating gas disk, caused by the nonlinear development of the convective instability, is considered. The mechanism suggested may be considered as the model of formation of the galaxy spiral configuration in a rotating pregalactic gas disk due to the development of the convective instability. Unlike the popular at present conception of ''density waves'', formation of the spiral configuration, from this point of view, is the single process of the development of instability in the pregalactic gas cloud. The further advantageous star formation in the vicinity of the central region, in a strip and sleeves is caused by higher concentration of gas density and temperature in these regions

  16. Instabilities simulations with wideband feedback systems: CMAD, HEADTAIL, WARP

    CERN Document Server

    Li, Kevin; Fox, J D; Pivi, M; Rivetta, C; Rumolo, G

    2013-01-01

    Transverse mode coupling (TMCI) and electron cloud instabilities (ECI) pose fundamental limitations on the acceptable beam intensities in the SPS at CERN. This in turn limits the ultimate achievable luminosity in the LHC. Therefore, future luminosity upgrades foresee methods for evading TMCI as well as ECI. Proposed approaches within the LHC Injector Upgrade (LIU) project include new optics with reduced transition energy as well as vacuum chamber coating techniques. As a complementary option, high bandwidth feedback systems may provide instability mitigation by actively damping the intra-bunch motion of unstable modes. In an effort to evaluate the potentials and limitations of such feedback systems and to characterise some of the specifications, a numerical model of a realistic feedback system has been developed and integrated into available instabilities simulation codes. Together with the implementation of this new feedback system model, CMAD and HEADTAIL have been used to investigate the impact of differen...

  17. Tracking Code for Microwave Instability

    International Nuclear Information System (INIS)

    Heifets, S.; SLAC

    2006-01-01

    To study microwave instability the tracking code is developed. For bench marking, results are compared with Oide-Yokoya results [1] for broad-band Q = 1 impedance. Results hint to two possible mechanisms determining the threshold of instability

  18. Instabilities in thin tunnel junctions

    International Nuclear Information System (INIS)

    Konkin, M.K.; Adler, J.G.

    1978-01-01

    Tunnel junctions prepared for inelastic electron tunneling spectroscopy are often plagued by instabilities in the 0-500-meV range. This paper relates the bias at which the instability occurs to the barrier thickness

  19. Cloud Processed CCN Suppress Stratus Cloud Drizzle

    Science.gov (United States)

    Hudson, J. G.; Noble, S. R., Jr.

    2017-12-01

    Conversion of sulfur dioxide to sulfate within cloud droplets increases the sizes and decreases the critical supersaturation, Sc, of cloud residual particles that had nucleated the droplets. Since other particles remain at the same sizes and Sc a size and Sc gap is often observed. Hudson et al. (2015) showed higher cloud droplet concentrations (Nc) in stratus clouds associated with bimodal high-resolution CCN spectra from the DRI CCN spectrometer compared to clouds associated with unimodal CCN spectra (not cloud processed). Here we show that CCN spectral shape (bimodal or unimodal) affects all aspects of stratus cloud microphysics and drizzle. Panel A shows mean differential cloud droplet spectra that have been divided according to traditional slopes, k, of the 131 measured CCN spectra in the Marine Stratus/Stratocumulus Experiment (MASE) off the Central California coast. K is generally high within the supersaturation, S, range of stratus clouds (< 0.5%). Because cloud processing decreases Sc of some particles, it reduces k. Panel A shows higher concentrations of small cloud droplets apparently grown on lower k CCN than clouds grown on higher k CCN. At small droplet sizes the concentrations follow the k order of the legend, black, red, green, blue (lowest to highest k). Above 13 µm diameter the lines cross and the hierarchy reverses so that blue (highest k) has the highest concentrations followed by green, red and black (lowest k). This reversed hierarchy continues into the drizzle size range (panel B) where the most drizzle drops, Nd, are in clouds grown on the least cloud-processed CCN (blue), while clouds grown on the most processed CCN (black) have the lowest Nd. Suppression of stratus cloud drizzle by cloud processing is an additional 2nd indirect aerosol effect (IAE) that along with the enhancement of 1st IAE by higher Nc (panel A) are above and beyond original IAE. However, further similar analysis is needed in other cloud regimes to determine if MASE was

  20. Numerical simulation of growth of flames formed in a two-dimensional mixing layer. 3rd Report. Flame instability induced by vortices; Nijigen kongo sonai ni keiseisareta kaen no seicho ni kansuru suchi simulation. 3. Uzu ni yotte reikisareru kaen no fuanteisei

    Energy Technology Data Exchange (ETDEWEB)

    Noda, S; Makino, H [Toyohashi University of Technology, Aichi (Japan); Nakajima, T [Kobe University, Kobe (Japan). Faculty of Engineering

    1996-03-25

    The flame instability induced by large vortices has been studied numerically. The numerical simulation is concerned with an unstable, two-dimensional, two-stream, spatially developing, confined, reacting shear layer. The behavior just after ignition is related to the flame instability which is affected strongly by large vortices in the mixing layer. Although flames are basically stable due to the balance between the burning velocity and the stream velocity, it is revealed that the leading edge is exposed under the strain in the mixing layer, and the flame becomes instable. Moreover, a method is also proposed to improve the flame stability by increasing the oxygen concentration in the oxidizer. 13 refs., 6 figs., 2 tabs.

  1. Relationship between cloud radiative forcing, cloud fraction and cloud albedo, and new surface-based approach for determining cloud albedo

    OpenAIRE

    Y. Liu; W. Wu; M. P. Jensen; T. Toto

    2011-01-01

    This paper focuses on three interconnected topics: (1) quantitative relationship between surface shortwave cloud radiative forcing, cloud fraction, and cloud albedo; (2) surfaced-based approach for measuring cloud albedo; (3) multiscale (diurnal, annual and inter-annual) variations and covariations of surface shortwave cloud radiative forcing, cloud fraction, and cloud albedo. An analytical expression is first derived to quantify the relationship between cloud radiative forcing, cloud fractio...

  2. Nonlinear evolution of MHD instabilities

    International Nuclear Information System (INIS)

    Bateman, G.; Hicks, H.R.; Wooten, J.W.; Dory, R.A.

    1975-01-01

    A 3-D nonlinear MHD computer code was used to study the time evolution of internal instabilities. Velocity vortex cells are observed to persist into the nonlinear evolution. Pressure and density profiles convect around these cells for a weak localized instability, or convect into the wall for a strong instability. (U.S.)

  3. DAФNE Operation with Electron-Cloud-Clearing Electrodes

    CERN Document Server

    Alesini, D; Gallo, A; Guiducci, S; Milardi, C; Stella, A; Zobov, Mikhail; De Santis, S; Demma, Theo; Raimondi, P

    2013-01-01

    The effects of an electron cloud (e-cloud) on beam dynamics are one of the major factors limiting performances of high intensity positron, proton, and ion storage rings. In the electron-positron collider DAΦNE, namely, a horizontal beam instability due to the electron-cloud effect has been identified as one of the main limitations on the maximum stored positron beam current and as a source of beam quality deterioration. During the last machine shutdown in order to mitigate such instability, special electrodes have been inserted in all dipole and wiggler magnets of the positron ring. It has been the first installation all over the world of this type since long metallic electrodes have been installed in all arcs of the collider positron ring and are currently used during the machine operation in collision. This has allowed a number of unprecedented measurements (e-cloud instabilities growth rate, transverse beam size variation, tune shifts along the bunch train) where the e-cloud contribution is clearly eviden...

  4. Interfacial instabilities in vibrated fluids

    Science.gov (United States)

    Porter, Jeff; Laverón-Simavilla, Ana; Tinao Perez-Miravete, Ignacio; Fernandez Fraile, Jose Javier

    2016-07-01

    Vibrations induce a range of different interfacial phenomena in fluid systems depending on the frequency and orientation of the forcing. With gravity, (large) interfaces are approximately flat and there is a qualitative difference between vertical and horizontal forcing. Sufficient vertical forcing produces subharmonic standing waves (Faraday waves) that extend over the whole interface. Horizontal forcing can excite both localized and extended interfacial phenomena. The vibrating solid boundaries act as wavemakers to excite traveling waves (or sloshing modes at low frequencies) but they also drive evanescent bulk modes whose oscillatory pressure gradient can parametrically excite subharmonic surface waves like cross-waves. Depending on the magnitude of the damping and the aspect ratio of the container, these locally generated surfaces waves may interact in the interior resulting in temporal modulation and other complex dynamics. In the case where the interface separates two fluids of different density in, for example, a rectangular container, the mass transfer due to vertical motion near the endwalls requires a counterflow in the interior region that can lead to a Kelvin-Helmholtz type instability and a ``frozen wave" pattern. In microgravity, the dominance of surface forces favors non-flat equilibrium configurations and the distinction between vertical and horizontal applied forcing can be lost. Hysteresis and multiplicity of solutions are more common, especially in non-wetting systems where disconnected (partial) volumes of fluid can be established. Furthermore, the vibrational field contributes a dynamic pressure term that competes with surface tension to select the (time averaged) shape of the surface. These new (quasi-static) surface configurations, known as vibroequilibria, can differ substantially from the hydrostatic state. There is a tendency for the interface to orient perpendicular to the vibrational axis and, in some cases, a bulge or cavity is induced

  5. The fragmentation of proto-globular clusters. I. Thermal instabilities

    International Nuclear Information System (INIS)

    Murray, S.D.; Lin, D.N.C.

    1989-01-01

    The metal abundances among the stars within a typical globular cluster are remarkably homogeneous. This indicates that star formation in these systems was a globally coordinated event which occurred over a time span less than or comparable to the collapse time scale of the cluster. This issue is addressed by assuming that the fragmentation of a proto-globular cluster cloud proceeded in two steps. In the first step, thermal instability led to the rapid growth of initial fluctuations. This led to a large contrast in the dynamical time scales between the perturbations and the parent cloud, and the perturbations then underwent gravitational instabilities on short time scales. This process is modeled using one-dimensional hydrodynamic simulations of clouds both with and without external heat sources and self-gravity. The models include the effects of a non-equilibrium H2 abundance. The results indicate that fragmentation can occur on time scales significantly less than the dynamical time scale of the parent cloud. 21 refs

  6. Cloud CCN feedback

    International Nuclear Information System (INIS)

    Hudson, J.G.

    1992-01-01

    Cloud microphysics affects cloud albedo precipitation efficiency and the extent of cloud feedback in response to global warming. Compared to other cloud parameters, microphysics is unique in its large range of variability and the fact that much of the variability is anthropogenic. Probably the most important determinant of cloud microphysics is the spectra of cloud condensation nuclei (CCN) which display considerable variability and have a large anthropogenic component. When analyzed in combination three field observation projects display the interrelationship between CCN and cloud microphysics. CCN were measured with the Desert Research Institute (DRI) instantaneous CCN spectrometer. Cloud microphysical measurements were obtained with the National Center for Atmospheric Research Lockheed Electra. Since CCN and cloud microphysics each affect the other a positive feedback mechanism can result

  7. Cloud vertical structure, precipitation, and cloud radiative effects over Tibetan Plateau

    Science.gov (United States)

    Liu, Y.; Yan, Y.; Lu, J.

    2017-12-01

    The vertical structure of clouds and its connection with precipitation and cloud radiative effects (CRE) over the Tibetan Plateau (TP) are analyzed and compared with its neighboring land and tropical oceans based on CloudSat and Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO) products and the Tropical Rainfall Measuring Mission (TRMM) precipitation data. Unique characteristics of cloud vertical structure and CRE over the TP are found. The cloud amount shows seasonal variation over the TP, which presents a single peak (located in 7-11 km) during January to April and two peaks (located in 5-8 km and 11-17 km separately) after mid-June, and then resumes to one peak (located in 5-10 km) after mid-August. Topography-induced restriction on moisture supply leads to a compression effect on clouds, i.e., the reduction in both cloud thickness and number of cloud layers, over the TP. The topography-induced compression effect is also shown in the range in the variation of cloud thickness and cloud-top height corresponding to different precipitation intensity, which is much smaller over the TP than its neighboring regions. In summer, cloud ice particles over the TP are mostly located at lower altitude (5-10 km) with richer variety of sizes and aggregation in no rain conditions compared to other regions. Ice water content becomes abundant and the number concentration tends to be dense at higher levels when precipitation is enhanced. The longwave CRE in the atmosphere over the TP is a net cooling effect. The vertical structure of CRE over the TP is unique compared to other regions: there exists a strong cooling layer of net CRE at the altitude of 8 km, from June to the beginning of October; the net radiative heating layer above the surface is shallower but stronger underneath 7 km and with a stronger seasonal variation over the TP.

  8. Instabilities in strongly coupled plasmas

    CERN Document Server

    Kalman, G J

    2003-01-01

    The conventional Vlasov treatment of beam-plasma instabilities is inappropriate when the plasma is strongly coupled. In the strongly coupled liquid state, the strong correlations between the dust grains fundamentally affect the conditions for instability. In the crystalline state, the inherent anisotropy couples the longitudinal and transverse polarizations, and results in unstable excitations in both polarizations. We summarize analyses of resonant and non-resonant, as well as resistive instabilities. We consider both ion-dust streaming and dust beam-plasma instabilities. Strong coupling, in general, leads to an enhancement of the growth rates. In the crystalline phase, a resonant transverse instability can be excited.

  9. Orphans and political instability.

    Science.gov (United States)

    Breuning, Marijke; Ishiyama, John

    2011-01-01

    This study investigates the security implications of growing orphan populations, particularly in Sub-Saharan Africa. Little has been written about the security implications of this especially vulnerable group of children. Are growing orphan populations associated with increases in political instability as has been suggested? Using data from several sources, we employ regression analysis to test whether Sub-Saharan African countries with larger proportions of orphans and those with increasing orphan populations experience higher rates of political instability. We find that the increase in the orphan population is related to an increasing incidence of civil conflict, but do not find a similar relationship for the proportion of orphans. In addition, we find that the causes of orphanhood matter. We conclude that increases in orphan populations (rather than simple proportions) are destabilizing. We suggest possible avenues for mediating the security risks posed by growing orphan populations.

  10. A trickle instability

    Science.gov (United States)

    Bossa, Benjamin

    2005-11-01

    We address the problem of the free fall of a long, horizontal and narrow liquid layer squeezed in a vertical open Hele-Shaw cell. The layer destabilizes as it falls down, evolving into a series of liquid blobs linked together by thin bridges, which ultimately break, leaving the initially connex fluid layer as a set a disjointed drops. The mechanism of this instability is the onset of a vertical pressure gradient due to the curvature difference of the moving contact line between the advancing interface and the rear interface. This instability, whose growth rate scales with a non-trivial power of the capillary number, amplifies indifferently a broad band of wavenumbers because of the flat shape of its dispersion relation in the thin layer limit. We will finally comment on the nature of the final fragmentation process and drop size distributions.

  11. Instability and internet design

    Directory of Open Access Journals (Sweden)

    Sandra Braman

    2016-09-01

    Full Text Available Instability - unpredictable but constant change in one’s environment and the means with which one deals with it - has replaced convergence as the focal problem for telecommunications policy in general and internet policy in particular. Those who designed what we now call the internet during the first decade of the effort (1969-1979, who in essence served simultaneously as its policy-makers, developed techniques for coping with instability of value for network designers today and for those involved with any kind of large-scale sociotechnical infrastructure. Analysis of the technical document series that was medium for and record of that design process reveals coping techniques that began with defining the problem and went on to include conceptual labour, social practices, and technical approaches.

  12. Imaging of patellofemoral instability

    International Nuclear Information System (INIS)

    Waldt, S.; Rummeny, E.J.

    2012-01-01

    Patellofemoral instability remains a diagnostic and therapeutic challenge due to its multifactorial genesis. The purpose of imaging is to systematically analyze predisposing factors, such as trochlear dysplasia, patella alta, tibial tuberosity-trochlear groove (TT-TG) distance, rotational deformities of the lower limb and patellar tilt. In order to evaluate anatomical abnormalities with a sufficient diagnostic accuracy, standardized measurement methods and implementation of various imaging modalities are necessary. Diagnosis of acute and often overlooked lateral patellar dislocation can be established with magnetic resonance imaging (MRI) because of its characteristic patterns of injury. Damage to the medial patellofemoral ligament (MPFL) has a significance just as high as the predisposing risk factors in relation to the cause of chronic instability. (orig.) [de

  13. Linear waves and instabilities

    International Nuclear Information System (INIS)

    Bers, A.

    1975-01-01

    The electrodynamic equations for small-amplitude waves and their dispersion relation in a homogeneous plasma are outlined. For such waves, energy and momentum, and their flow and transformation, are described. Perturbation theory of waves is treated and applied to linear coupling of waves, and the resulting instabilities from such interactions between active and passive waves. Linear stability analysis in time and space is described where the time-asymptotic, time-space Green's function for an arbitrary dispersion relation is developed. The perturbation theory of waves is applied to nonlinear coupling, with particular emphasis on pump-driven interactions of waves. Details of the time--space evolution of instabilities due to coupling are given. (U.S.)

  14. Cosmic ray driven instability

    International Nuclear Information System (INIS)

    Dorfi, E.A.; Drury, L.O.

    1985-01-01

    The interaction between energetic charged particles and thermal plasma, which forms the basis of diffusive shock acceleration, leads also to interesting dynamical phenomena. For a compressional mode propagating in a system with homoeneous energetic particle pressure it is well known that friction with the energetic particles leads to damping. The linear theory of this effect has been analyzed in detail by Ptuskin. Not so obvious is that a non-uniform energetic particle pressure can in addition amplify compressional disturbances. If the pressure gradient is sufficiently steep this growth can dominate the frictional damping and lead to an instability. It is important to not that this effect results from the collective nature of the interaction between the energetic particles and the gas and is not connected with the Parker instability, nor with the resonant amplification of Alfven waves

  15. Hybrid cloud for dummies

    CERN Document Server

    Hurwitz, Judith; Halper, Fern; Kirsch, Dan

    2012-01-01

    Understand the cloud and implement a cloud strategy for your business Cloud computing enables companies to save money by leasing storage space and accessing technology services through the Internet instead of buying and maintaining equipment and support services. Because it has its own unique set of challenges, cloud computing requires careful explanation. This easy-to-follow guide shows IT managers and support staff just what cloud computing is, how to deliver and manage cloud computing services, how to choose a service provider, and how to go about implementation. It also covers security and

  16. Secure cloud computing

    CERN Document Server

    Jajodia, Sushil; Samarati, Pierangela; Singhal, Anoop; Swarup, Vipin; Wang, Cliff

    2014-01-01

    This book presents a range of cloud computing security challenges and promising solution paths. The first two chapters focus on practical considerations of cloud computing. In Chapter 1, Chandramouli, Iorga, and Chokani describe the evolution of cloud computing and the current state of practice, followed by the challenges of cryptographic key management in the cloud. In Chapter 2, Chen and Sion present a dollar cost model of cloud computing and explore the economic viability of cloud computing with and without security mechanisms involving cryptographic mechanisms. The next two chapters addres

  17. Clouds of Venus

    Energy Technology Data Exchange (ETDEWEB)

    Knollenberg, R G [Particle Measuring Systems, Inc., 1855 South 57th Court, Boulder, Colorado 80301, U.S.A.; Hansen, J [National Aeronautics and Space Administration, New York (USA). Goddard Inst. for Space Studies; Ragent, B [National Aeronautics and Space Administration, Moffett Field, Calif. (USA). Ames Research Center; Martonchik, J [Jet Propulsion Lab., Pasadena, Calif. (USA); Tomasko, M [Arizona Univ., Tucson (USA)

    1977-05-01

    The current state of knowledge of the Venusian clouds is reviewed. The visible clouds of Venus are shown to be quite similar to low level terrestrial hazes of strong anthropogenic influence. Possible nucleation and particle growth mechanisms are presented. The Pioneer Venus experiments that emphasize cloud measurements are described and their expected findings are discussed in detail. The results of these experiments should define the cloud particle composition, microphysics, thermal and radiative heat budget, rough dynamical features and horizontal and vertical variations in these and other parameters. This information should be sufficient to initialize cloud models which can be used to explain the cloud formation, decay, and particle life cycle.

  18. Instability in dynamic fracture

    Science.gov (United States)

    Fineberg, J.; Marder, M.

    1999-05-01

    The fracture of brittle amorphous materials is an especially challenging problem, because the way a large object shatters is intimately tied to details of cohesion at microscopic scales. This subject has been plagued by conceptual puzzles, and to make matters worse, experiments seemed to contradict the most firmly established theories. In this review, we will show that the theory and experiments fit within a coherent picture where dynamic instabilities of a crack tip play a crucial role. To accomplish this task, we first summarize the central results of linear elastic dynamic fracture mechanics, an elegant and powerful description of crack motion from the continuum perspective. We point out that this theory is unable to make predictions without additional input, information that must come either from experiment, or from other types of theories. We then proceed to discuss some of the most important experimental observations, and the methods that were used to obtain the them. Once the flux of energy to a crack tip passes a critical value, the crack becomes unstable, and it propagates in increasingly complicated ways. As a result, the crack cannot travel as quickly as theory had supposed, fracture surfaces become rough, it begins to branch and radiate sound, and the energy cost for crack motion increases considerably. All these phenomena are perfectly consistent with the continuum theory, but are not described by it. Therefore, we close the review with an account of theoretical and numerical work that attempts to explain the instabilities. Currently, the experimental understanding of crack tip instabilities in brittle amorphous materials is fairly detailed. We also have a detailed theoretical understanding of crack tip instabilities in crystals, reproducing qualitatively many features of the experiments, while numerical work is beginning to make the missing connections between experiment and theory.

  19. Relativistic centrifugal instability

    Science.gov (United States)

    Gourgouliatos, Konstantinos N.; Komissarov, Serguei S.

    2018-03-01

    Near the central engine, many astrophysical jets are expected to rotate about their axis. Further out they are expected to go through the processes of reconfinement and recollimation. In both these cases, the flow streams along a concave surface and hence, it is subject to the centrifugal force. It is well known that such flows may experience the centrifugal instability (CFI), to which there are many laboratory examples. The recent computer simulations of relativistic jets from active galactic nuclei undergoing the process of reconfinement show that in such jets CFI may dominate over the Kelvin-Helmholtz instability associated with velocity shear (Gourgouliatos & Komissarov). In this letter, we generalize the Rayleigh criterion for CFI in rotating fluids to relativistic flows using a heuristic analysis. We also present the results of computer simulations which support our analytic criterion for the case of an interface separating two uniformly rotating cylindrical flows. We discuss the difference between CFI and the Rayleigh-Taylor instability in flows with curved streamlines.

  20. Analyses of MHD instabilities

    International Nuclear Information System (INIS)

    Takeda, Tatsuoki

    1985-01-01

    In this article analyses of the MHD stabilities which govern the global behavior of a fusion plasma are described from the viewpoint of the numerical computation. First, we describe the high accuracy calculation of the MHD equilibrium and then the analysis of the linear MHD instability. The former is the basis of the stability analysis and the latter is closely related to the limiting beta value which is a very important theoretical issue of the tokamak research. To attain a stable tokamak plasma with good confinement property it is necessary to control or suppress disruptive instabilities. We, next, describe the nonlinear MHD instabilities which relate with the disruption phenomena. Lastly, we describe vectorization of the MHD codes. The above MHD codes for fusion plasma analyses are relatively simple though very time-consuming and parts of the codes which need a lot of CPU time concentrate on a small portion of the codes, moreover, the codes are usually used by the developers of the codes themselves, which make it comparatively easy to attain a high performance ratio on the vector processor. (author)

  1. Ion temperature gradient instability

    International Nuclear Information System (INIS)

    1989-01-01

    Anomalous ion thermal conductivity remains an open physics issue for the present generation of high temperature Tokamaks. It is generally believed to be due to Ion Temperature Gradient Instability (η i mode). However, it has been difficult, if not impossible to identify this instability and study the anomalous transport due to it, directly. Therefore the production and identification of the mode is pursued in the simpler and experimentally convenient configuration of the Columbia Linear Machine (CLM). CLM is a steady state machine which already has all the appropriate parameters, except η i . This parameter is being increased to the appropriate value of the order of 1 by 'feathering' a tungsten screen located between the plasma source and the experimental cell to flatten the density profile and appropriate redesign of heating antennas to steepen the ion temperature profile. Once the instability is produced and identified, a thorough study of the characteristics of the mode can be done via a wide range of variation of all the critical parameters: η i , parallel wavelength, etc

  2. Radiative properties of clouds

    International Nuclear Information System (INIS)

    Twomey, S.

    1993-01-01

    The climatic effects of condensation nuclei in the formation of cloud droplets and the subsequent role of the cloud droplets as contributors to the planetary short-wave albedo is emphasized. Microphysical properties of clouds, which can be greatly modified by the degree of mixing with cloud-free air from outside, are discussed. The effect of clouds on visible radiation is assessed through multiple scattering of the radiation. Cloudwater or ice absorbs more with increasing wavelength in the near-infrared region, with water vapor providing the stronger absorption over narrower wavelength bands. Cloud thermal infrared absorption can be solely related to liquid water content at least for shallow clouds and clouds in the early development state. Three-dimensional general circulation models have been used to study the climatic effect of clouds. It was found for such studies (which did not consider variations in cloud albedo) that the cooling effects due to the increase in planetary short-wave albedo from clouds were offset by heating effects due to thermal infrared absorption by the cloud. Two permanent direct effects of increased pollution are discussed in this chapter: (a) an increase of absorption in the visible and near infrared because of increased amounts of elemental carbon, which gives rise to a warming effect climatically, and (b) an increased optical thickness of clouds due to increasing cloud droplet number concentration caused by increasing cloud condensation nuclei number concentration, which gives rise to a cooling effect climatically. An increase in cloud albedo from 0.7 to 0.87 produces an appreciable climatic perturbation of cooling up to 2.5 K at the ground, using a hemispheric general circulation model. Effects of pollution on cloud thermal infrared absorption are negligible

  3. Genomic instability--an evolving hallmark of cancer.

    Science.gov (United States)

    Negrini, Simona; Gorgoulis, Vassilis G; Halazonetis, Thanos D

    2010-03-01

    Genomic instability is a characteristic of most cancers. In hereditary cancers, genomic instability results from mutations in DNA repair genes and drives cancer development, as predicted by the mutator hypothesis. In sporadic (non-hereditary) cancers the molecular basis of genomic instability remains unclear, but recent high-throughput sequencing studies suggest that mutations in DNA repair genes are infrequent before therapy, arguing against the mutator hypothesis for these cancers. Instead, the mutation patterns of the tumour suppressor TP53 (which encodes p53), ataxia telangiectasia mutated (ATM) and cyclin-dependent kinase inhibitor 2A (CDKN2A; which encodes p16INK4A and p14ARF) support the oncogene-induced DNA replication stress model, which attributes genomic instability and TP53 and ATM mutations to oncogene-induced DNA damage.

  4. Study of irradiation induced defects and phase instability in β phase of Zr Excel alloy with in-situ heavy ion irradiation

    International Nuclear Information System (INIS)

    Yu, H.; Yao, Z.; Kirk, M.A.; Daymond, M.R.

    2015-01-01

    In situ heavy ion irradiation with 1 MeV Kr"2"+ was carried out to study irradiation induced phase change and atomic lattice defects in theβ phase of Zr Excel alloy. No decomposition of β-Zr was observed under irradiation at either 200 "oC or 450 "oC. However, ω-Zr particles experienced shape change and shrinkage associated enrichment of Fe in the β/ω interface at 200 "oC irradiation but not at 450 "oC. The defect evolution in the β-phase was examined with single phase Zr-20Nb alloy. It was found that dislocation loops with Burgers vector 1/2 and both present in β-Zr under room temperature irradiation. (author)

  5. Study of irradiation induced defects and phase instability in β phase of Zr Excel alloy with in-situ heavy ion irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Yu, H.; Yao, Z., E-mail: 12hy1@queensu.ca [Queen' s University, Department of Mechanical and Materials Engineering, Kingston, ON (Canada); Kirk, M.A. [Argonne National Laboratory, Materials Science Division, Argonne, IL (United States); Daymond, M.R. [Queen' s University, Department of Mechanical and Materials Engineering, Kingston, ON (Canada)

    2015-07-01

    In situ heavy ion irradiation with 1 MeV Kr{sup 2+} was carried out to study irradiation induced phase change and atomic lattice defects in theβ phase of Zr Excel alloy. No decomposition of β-Zr was observed under irradiation at either 200 {sup o}C or 450 {sup o}C. However, ω-Zr particles experienced shape change and shrinkage associated enrichment of Fe in the β/ω interface at 200 {sup o}C irradiation but not at 450 {sup o}C. The defect evolution in the β-phase was examined with single phase Zr-20Nb alloy. It was found that dislocation loops with Burgers vector 1/2<111> and <001> both present in β-Zr under room temperature irradiation. (author)

  6. Subjeans Condensations due to a Thermal Instability

    Science.gov (United States)

    Opher, R.; Valio, A.

    1990-11-01

    RESUMEN. Las observaciones recientes muestran que las nubes moleculares no son homogeneas, sino que tienen condensaciones. Se observa que estas condensaciones estan libres gravitacionalmente. C6mo se forman estas condensaciones? Sugerimos explicar estas conden sac jones como debidas a que la inestabilidad termica ayuda a la gravedad. Se estudi6 una funci5n de enfriamiento por gramo de la forma general A p T , en donde p y T son la densidad y la temperatura. Estamos interesados en el valor maximo de para la cual el colapso ocurre. Se estudiaron varios mode- los. Nuestros resultados indican que los valores de comparables con aquellos sugeridos por la literatura (1 son suficientes para provocar el colapso de masas inferiores a la masa de Jeans por medio de inestabilidad termica, ayudada por gravedad y asi se forman las condensaciones libres gravitacionalmente. ABSTRACT: Recent observations show that molecular clouds are not homogeneous, but clumpy. Some clumps are observed to be gravitationally unbound. How did these clumps then form? We suggest explaining these condensation as due to thermal instability aiding gravit y The cooling function per gram studied is of the general form A p T,where pand T are the density and temperature, respectively. We are interested in the maximum value of for which collapse still occurs. Various models are studied. Our results indicate that values comparable to those suggested in the literature (1 < %< 2) are sufficient to trigger the collapse of subjeans masses by thermal instability, when aided by gravity, and form the observed gravitationally unbound clumps. Keq o : HYDRODYNAMICS - INTERSTELLAR CLOUDS

  7. Dynamical instability of hot and compressed nuclei

    International Nuclear Information System (INIS)

    Ngo, C.; Leray, S.; Spina, M.E.; Ngo, H.

    1989-01-01

    The dynamical evolution of a hot and compressed nucleus is described by means of an extended liquid-drop model. Using only the continuity equation and the energy conservation we show that the system expands after a while. The possible global instabilities of the drop are studied by applying the general conditions of stability of dynamical systems. We find that the nucleus is unstable if it can reach a low density configuration (≅0.07 nucleon/fm 3 ). Such a configuration is obtained if the initial compression of the nucleus is large enough. It is shown that the thermal excitation energy has much less influence than the compressional energy. These instability conditions are in good agreement with those obtained previously within the framework of lattice percolation and the same model for the dynamical expansion. Since local instabilities may also very likely be present, we propose to study them using a restructured aggregation model. They lead to a multifragmentation of the system, a mechanism which is known experimentally to exist. We find that local instabilities occur at smaller (but very close) density values than global ones. A moment analysis of the calculated multifragmentation events allows to extract a critical exponent in excellent agreement with the one deduced experimentally from Au-induced reactions. (orig.)

  8. Periodic Spacing of Protocluster Clumps in a Filamentary Infrared Dark Cloud

    Science.gov (United States)

    Jackson, James M.; Finn, S.; Rathborne, J. M.; Simon, R.

    2010-05-01

    The ''Nessie'' nebula is an extremely filamentary infrared dark cloud, with an aspect ratio of over 300:1. HNC 1-0 observations with the Australia Telescope National Facility's Mopra Telescope demonstrate that Nessie is a single, coherent cloud with high densities (n > 105 cm-3). The filamentary cloud contains a number of protocluster clumps with a nearly regular, periodic spacing of 5 pc. Such clumps naturally arise from the ''varicose'' fluid instability of a self-gravitating fluid cylinder. Because of the ubiquitous association between massive clusters and filamentary molecular clouds (e.g., Orion, NGC 6334, etc.), we speculate that clusters naturally arise from filamentary infrared dark clouds via fluid instabilities.

  9. Testing the gravitational instability hypothesis?

    Science.gov (United States)

    Babul, Arif; Weinberg, David H.; Dekel, Avishai; Ostriker, Jeremiah P.

    1994-01-01

    We challenge a widely accepted assumption of observational cosmology: that successful reconstruction of observed galaxy density fields from measured galaxy velocity fields (or vice versa), using the methods of gravitational instability theory, implies that the observed large-scale structures and large-scale flows were produced by the action of gravity. This assumption is false, in that there exist nongravitational theories that pass the reconstruction tests and gravitational theories with certain forms of biased galaxy formation that fail them. Gravitational instability theory predicts specific correlations between large-scale velocity and mass density fields, but the same correlations arise in any model where (a) structures in the galaxy distribution grow from homogeneous initial conditions in a way that satisfies the continuity equation, and (b) the present-day velocity field is irrotational and proportional to the time-averaged velocity field. We demonstrate these assertions using analytical arguments and N-body simulations. If large-scale structure is formed by gravitational instability, then the ratio of the galaxy density contrast to the divergence of the velocity field yields an estimate of the density parameter Omega (or, more generally, an estimate of beta identically equal to Omega(exp 0.6)/b, where b is an assumed constant of proportionality between galaxy and mass density fluctuations. In nongravitational scenarios, the values of Omega or beta estimated in this way may fail to represent the true cosmological values. However, even if nongravitational forces initiate and shape the growth of structure, gravitationally induced accelerations can dominate the velocity field at late times, long after the action of any nongravitational impulses. The estimated beta approaches the true value in such cases, and in our numerical simulations the estimated beta values are reasonably accurate for both gravitational and nongravitational models. Reconstruction tests

  10. Moving towards Cloud Security

    Directory of Open Access Journals (Sweden)

    Edit Szilvia Rubóczki

    2015-01-01

    Full Text Available Cloud computing hosts and delivers many different services via Internet. There are a lot of reasons why people opt for using cloud resources. Cloud development is increasing fast while a lot of related services drop behind, for example the mass awareness of cloud security. However the new generation upload videos and pictures without reason to a cloud storage, but only few know about data privacy, data management and the proprietary of stored data in the cloud. In an enterprise environment the users have to know the rule of cloud usage, however they have little knowledge about traditional IT security. It is important to measure the level of their knowledge, and evolve the training system to develop the security awareness. The article proves the importance of suggesting new metrics and algorithms for measuring security awareness of corporate users and employees to include the requirements of emerging cloud security.

  11. Cloud Computing for radiologists.

    Science.gov (United States)

    Kharat, Amit T; Safvi, Amjad; Thind, Ss; Singh, Amarjit

    2012-07-01

    Cloud computing is a concept wherein a computer grid is created using the Internet with the sole purpose of utilizing shared resources such as computer software, hardware, on a pay-per-use model. Using Cloud computing, radiology users can efficiently manage multimodality imaging units by using the latest software and hardware without paying huge upfront costs. Cloud computing systems usually work on public, private, hybrid, or community models. Using the various components of a Cloud, such as applications, client, infrastructure, storage, services, and processing power, Cloud computing can help imaging units rapidly scale and descale operations and avoid huge spending on maintenance of costly applications and storage. Cloud computing allows flexibility in imaging. It sets free radiology from the confines of a hospital and creates a virtual mobile office. The downsides to Cloud computing involve security and privacy issues which need to be addressed to ensure the success of Cloud computing in the future.

  12. Cloud Computing for radiologists

    International Nuclear Information System (INIS)

    Kharat, Amit T; Safvi, Amjad; Thind, SS; Singh, Amarjit

    2012-01-01

    Cloud computing is a concept wherein a computer grid is created using the Internet with the sole purpose of utilizing shared resources such as computer software, hardware, on a pay-per-use model. Using Cloud computing, radiology users can efficiently manage multimodality imaging units by using the latest software and hardware without paying huge upfront costs. Cloud computing systems usually work on public, private, hybrid, or community models. Using the various components of a Cloud, such as applications, client, infrastructure, storage, services, and processing power, Cloud computing can help imaging units rapidly scale and descale operations and avoid huge spending on maintenance of costly applications and storage. Cloud computing allows flexibility in imaging. It sets free radiology from the confines of a hospital and creates a virtual mobile office. The downsides to Cloud computing involve security and privacy issues which need to be addressed to ensure the success of Cloud computing in the future

  13. Cloud computing for radiologists

    Directory of Open Access Journals (Sweden)

    Amit T Kharat

    2012-01-01

    Full Text Available Cloud computing is a concept wherein a computer grid is created using the Internet with the sole purpose of utilizing shared resources such as computer software, hardware, on a pay-per-use model. Using Cloud computing, radiology users can efficiently manage multimodality imaging units by using the latest software and hardware without paying huge upfront costs. Cloud computing systems usually work on public, private, hybrid, or community models. Using the various components of a Cloud, such as applications, client, infrastructure, storage, services, and processing power, Cloud computing can help imaging units rapidly scale and descale operations and avoid huge spending on maintenance of costly applications and storage. Cloud computing allows flexibility in imaging. It sets free radiology from the confines of a hospital and creates a virtual mobile office. The downsides to Cloud computing involve security and privacy issues which need to be addressed to ensure the success of Cloud computing in the future.

  14. Flow instability and critical heat flux in a ribbed annulus

    International Nuclear Information System (INIS)

    Yang, B.W.; Dougherty, T.; Fighetti, C.; Kokolis, S.; Reddy, G.D.; McAssey, E.V. Jr.; Coutts, A.

    1993-01-01

    An experimental program has been conducted to determine the onset of flow instability point in a heated annulus which is divided into four sub channels by non-conducting ribs. The onset of flow instability is identified by the minimum point in the pressure drop-velocity curve. Comparison with a ribless annulus show that the presence of ribs increases the minimum point velocity. In addition, data are presented which show that under certain conditions premature CHF can be induced by the ribs

  15. Surface wave instability in bounded magnetized plasma with inhomogeneous particle stream

    Energy Technology Data Exchange (ETDEWEB)

    Jovanovic, D.; Vukovic, S. (Belgrade Univ. (Yugoslavia). Inst. za Fiziku)

    1981-02-01

    The instability of surface wave modes in a semi infinite magnetoactive plasma with a non-homogeneous particle stream is studied. The existence of two possible mechanisms for the development of the instability: induced anomalous Doppler effect and induced Cherenkov effect is demonstrated. Related growth-rates and stability criteria are calculated.

  16. Surface wave instability in bounded magnetized plasma with inhomogeneous particle stream

    International Nuclear Information System (INIS)

    Jovanovic, D.; Vukovic, S.

    1981-01-01

    The instability of surface wave modes in a semi infinite magnetoactive plasma with a non-homogeneous particle stream is studied. The existence of two possible mechanisms for the development of the instability: induced anomalous Doppler effect and induced Cherenkov effect is demonstrated. Related growth-rates and stability criteria are calculated. (author)

  17. Tangential neutral-beam--driven instabilities in the Princeton beta experiment

    International Nuclear Information System (INIS)

    Heidbrink, W.W.; Bol, K.; Buchenauer, D.

    1986-01-01

    During tangential neutral-beam injection into the PBX tokamak, bursts of two types of instabilities are observed. One instability occurs in the frequency range 120--210 kHz and the other oscillates predominantly near the frequency of bulk plasma rotation (20--30 kHz). Both instabilities correlate with drops in neutron emission and bursts in charge-exchange neutral flux, indicating that beam ions are removed from the center of the plasma by the instabilities. The central losses are comparable to the losses induced by the fishbone instability during perpendicular injection

  18. Marine cloud brightening

    OpenAIRE

    Latham, John; Bower, Keith; Choularton, Tom; Coe, Hugh; Connolly, Paul; Cooper, Gary; Craft, Tim; Foster, Jack; Gadian, Alan; Galbraith, Lee; Iacovides, Hector; Johnston, David; Launder, Brian; Leslie, Brian; Meyer, John

    2012-01-01

    The idea behind the marine cloud-brightening (MCB) geoengineering technique is that seeding marine stratocumulus clouds with copious quantities of roughly monodisperse sub-micrometre sea water particles might significantly enhance the cloud droplet number concentration, and thereby the cloud albedo and possibly longevity. This would produce a cooling, which general circulation model (GCM) computations suggest could—subject to satisfactory resolution of technical and scientific problems identi...

  19. Cloud computing strategies

    CERN Document Server

    Chorafas, Dimitris N

    2011-01-01

    A guide to managing cloud projects, Cloud Computing Strategies provides the understanding required to evaluate the technology and determine how it can be best applied to improve business and enhance your overall corporate strategy. Based on extensive research, it examines the opportunities and challenges that loom in the cloud. It explains exactly what cloud computing is, what it has to offer, and calls attention to the important issues management needs to consider before passing the point of no return regarding financial commitments.

  20. Towards Indonesian Cloud Campus

    OpenAIRE

    Thamrin, Taqwan; Lukman, Iing; Wahyuningsih, Dina Ika

    2013-01-01

    Nowadays, Cloud Computing is most discussed term in business and academic environment.Cloud campus has many benefits such as accessing the file storages, e-mails, databases,educational resources, research applications and tools anywhere for faculty, administrators,staff, students and other users in university, on demand. Furthermore, cloud campus reduces universities’ IT complexity and cost.This paper discuss the implementation of Indonesian cloud campus and various opportunies and benefits...

  1. Cloud Infrastructure Security

    OpenAIRE

    Velev , Dimiter; Zlateva , Plamena

    2010-01-01

    Part 4: Security for Clouds; International audience; Cloud computing can help companies accomplish more by eliminating the physical bonds between an IT infrastructure and its users. Users can purchase services from a cloud environment that could allow them to save money and focus on their core business. At the same time certain concerns have emerged as potential barriers to rapid adoption of cloud services such as security, privacy and reliability. Usually the information security professiona...

  2. Cloud services in organization

    OpenAIRE

    FUXA, Jan

    2013-01-01

    The work deals with the definition of the word cloud computing, cloud computing models, types, advantages, disadvantages, and comparing SaaS solutions such as: Google Apps and Office 365 in the area of electronic communications. The work deals with the use of cloud computing in the corporate practice, both good and bad practice. The following section describes the methodology for choosing the appropriate cloud service organization. Another part deals with analyzing the possibilities of SaaS i...

  3. Orchestrating Your Cloud Orchestra

    OpenAIRE

    Hindle, Abram

    2015-01-01

    Cloud computing potentially ushers in a new era of computer music performance with exceptionally large computer music instruments consisting of 10s to 100s of virtual machines which we propose to call a `cloud-orchestra'. Cloud computing allows for the rapid provisioning of resources, but to deploy such a complicated and interconnected network of software synthesizers in the cloud requires a lot of manual work, system administration knowledge, and developer/operator skills. This is a barrier ...

  4. Cloud security mechanisms

    OpenAIRE

    2014-01-01

    Cloud computing has brought great benefits in cost and flexibility for provisioning services. The greatest challenge of cloud computing remains however the question of security. The current standard tools in access control mechanisms and cryptography can only partly solve the security challenges of cloud infrastructures. In the recent years of research in security and cryptography, novel mechanisms, protocols and algorithms have emerged that offer new ways to create secure services atop cloud...

  5. Cloud computing for radiologists

    OpenAIRE

    Amit T Kharat; Amjad Safvi; S S Thind; Amarjit Singh

    2012-01-01

    Cloud computing is a concept wherein a computer grid is created using the Internet with the sole purpose of utilizing shared resources such as computer software, hardware, on a pay-per-use model. Using Cloud computing, radiology users can efficiently manage multimodality imaging units by using the latest software and hardware without paying huge upfront costs. Cloud computing systems usually work on public, private, hybrid, or community models. Using the various components of a Cloud, such as...

  6. Cloud Robotics Model

    OpenAIRE

    Mester, Gyula

    2015-01-01

    Cloud Robotics was born from the merger of service robotics and cloud technologies. It allows robots to benefit from the powerful computational, storage, and communications resources of modern data centres. Cloud robotics allows robots to take advantage of the rapid increase in data transfer rates to offload tasks without hard real time requirements. Cloud Robotics has rapidly gained momentum with initiatives by companies such as Google, Willow Garage and Gostai as well as more than a dozen a...

  7. Genomics With Cloud Computing

    OpenAIRE

    Sukhamrit Kaur; Sandeep Kaur

    2015-01-01

    Abstract Genomics is study of genome which provides large amount of data for which large storage and computation power is needed. These issues are solved by cloud computing that provides various cloud platforms for genomics. These platforms provides many services to user like easy access to data easy sharing and transfer providing storage in hundreds of terabytes more computational power. Some cloud platforms are Google genomics DNAnexus and Globus genomics. Various features of cloud computin...

  8. Impact of cloud radiative heating on East Asian summer monsoon circulation

    International Nuclear Information System (INIS)

    Guo, Zhun; Zhou, Tianjun; Wang, Minghuai; Qian, Yun

    2015-01-01

    The impacts of cloud radiative heating on the East Asian Summer Monsoon (EASM) over southeastern China (105°–125°E, 20°–35°N) are addressed by using the Community Atmosphere Model version 5 (CAM5). Sensitivity experiments demonstrate that the radiative heating of clouds leads to a positive effect on the local EASM circulation over southeastern China. Without the radiative heating of clouds, the EASM circulation and precipitation would be much weaker than that in normal conditions. The longwave heating of clouds dominates the changes of EASM circulation. The positive effect of clouds on EASM circulation is explained by the thermodynamic energy equation, i.e. the different heating rate between cloud base and cloud top enhances the convective instability over southeastern China, which consequently enhances updraft. The strong updraft would further result in a southward meridional wind above the center of the updraft through Sverdrup vorticity balance. (letter)

  9. Competing Structural Instabilities in the Ruddlesden–Popper Derivatives HRTiO4 (R = Rare Earths): Oxygen Octahedral Rotations Inducing Noncentrosymmetricity and Layer Sliding Retaining Centrosymmetricity

    International Nuclear Information System (INIS)

    Sen Gupta, Arnab; Akamatsu, Hirofumi; Brown, Forrest G.; Nguyen, Minh An T.

    2016-01-01

    We report the discovery of noncentrosymmetry in the family of HRTiO 4 (R = Eu, Gd, Dy) layered oxides possessing a Ruddlesden-Popper derivative structure, by second harmonic generation and synchrotron x-ray diffraction with the support of density functional theory calculations. These oxides were previously thought to possess inversion symmetry. Here, inversion symmetry is broken by oxygen octahedral rotations, a mechanism that is not active in simple perovskites. We discover a competition between oxygen octahedral rotations and sliding of the octahedral perovskite blocks at the OH layers. For the smaller rare earth ions, R = Eu, Gd, Dy, which favor the octahedral rotations, noncentrosymmetry is present but the sliding at the OH layer is absent. For the larger rare earth ions, R = Nd and Sm, the octahe-dral rotations are absent, but sliding of the octahedral blocks at the OH layer is present, likely to optimize the hydrogen bond length arising from the directional nature of these bonds in the crystal structure. The study reveals a new mechanism for inducing noncentrosymmetry in layered oxides, and chemical-structural effects related to rare earth ion size and hydrogen bonding that can turn this mechanism on and off. In conclusion, we construct a complete phase diagram of temperature versus rare earth ionic radius for the HRTiO 4 family.

  10. Ab initio study of lattice instabilities of zinc chalcogenides ZnX (X=O, S, Se, Te induced by ultrafast intense laser irradiation

    Directory of Open Access Journals (Sweden)

    Dahua Ren

    2017-09-01

    Full Text Available Ab initio calculations of lattice constants, lattice stabilities of ZnX (X=O, S, Se, Te at different electronic temperatures (Te have been performed using generalized gradient approximation (GGA pseudopotential method within the density functional theory (DFT. The calculated phonon frequencies of ZnX at Te = 0 eV accord well with the experimental and other theoretical values. Firstly, it is indicated that the lattice constants of ZnX increase and all the phonon frequencies reduce as Te increases. Additionally, the transverse-acoustic phonon frequencies of ZnX are imaginary with the elevation of Te, namely the lattices of ZnX become unstable under ultrafast intense laser irradiation. Moreover, the transverse optical mode-longitudinal optical mode (LO-TO splitting degree of ZnX (X=S, Se, Te gradually decreases as the electronic temperature increases, mainly due to the reason that the electronic excitation weakens the strength ionicity of ionic crystal ZnX under intense laser irradiation. However, the LO-TO splitting degree of ZnO firstly increases and then decreases with the increase of electronic temperature. After that, it can be helpful for understanding the mechanism of ultrafast intense laser induced semiconductors damage.

  11. Chargeback for cloud services.

    NARCIS (Netherlands)

    Baars, T.; Khadka, R.; Stefanov, H.; Jansen, S.; Batenburg, R.; Heusden, E. van

    2014-01-01

    With pay-per-use pricing models, elastic scaling of resources, and the use of shared virtualized infrastructures, cloud computing offers more efficient use of capital and agility. To leverage the advantages of cloud computing, organizations have to introduce cloud-specific chargeback practices.

  12. On CLOUD nine

    CERN Multimedia

    2009-01-01

    The team from the CLOUD experiment - the world’s first experiment using a high-energy particle accelerator to study the climate - were on cloud nine after the arrival of their new three-metre diameter cloud chamber. This marks the end of three years’ R&D and design, and the start of preparations for data taking later this year.

  13. Cloud Computing Explained

    Science.gov (United States)

    Metz, Rosalyn

    2010-01-01

    While many talk about the cloud, few actually understand it. Three organizations' definitions come to the forefront when defining the cloud: Gartner, Forrester, and the National Institutes of Standards and Technology (NIST). Although both Gartner and Forrester provide definitions of cloud computing, the NIST definition is concise and uses…

  14. Greening the Cloud

    NARCIS (Netherlands)

    van den Hoed, Robert; Hoekstra, Eric; Procaccianti, G.; Lago, P.; Grosso, Paola; Taal, Arie; Grosskop, Kay; van Bergen, Esther

    The cloud has become an essential part of our daily lives. We use it to store our documents (Dropbox), to stream our music and lms (Spotify and Net ix) and without giving it any thought, we use it to work on documents in the cloud (Google Docs). The cloud forms a massive storage and processing

  15. Security in the cloud.

    Science.gov (United States)

    Degaspari, John

    2011-08-01

    As more provider organizations look to the cloud computing model, they face a host of security-related questions. What are the appropriate applications for the cloud, what is the best cloud model, and what do they need to know to choose the best vendor? Hospital CIOs and security experts weigh in.

  16. Mouse model of proximal colon-specific tumorigenesis driven by microsatellite instability-induced Cre-mediated inactivation of Apc and activation of Kras.

    Science.gov (United States)

    Kawaguchi, Yasuo; Hinoi, Takao; Saito, Yasufumi; Adachi, Tomohiro; Miguchi, Masashi; Niitsu, Hiroaki; Sasada, Tatsunari; Shimomura, Manabu; Egi, Hiroyuki; Oka, Shiro; Tanaka, Shinji; Chayama, Kazuaki; Sentani, Kazuhiro; Oue, Naohide; Yasui, Wataru; Ohdan, Hideki

    2016-05-01

    KRAS gene mutations are found in 40-50% of colorectal cancer cases, but their functional contribution is not fully understood. To address this issue, we generated genetically engineered mice with colon tumors expressing an oncogenic Kras(G12D) allele in the context of the Adenomatous polyposis coli (Apc) deficiency to compare them to tumors harboring Apc deficiency alone. CDX2P9.5-G22Cre (referred to as G22Cre) mice showing inducible Cre recombinase transgene expression in the proximal colon controlled under the CDX2 gene promoter were intercrossed with Apc (flox/flox) mice and LSL-Kras (G12D) mice carrying loxP-flanked Apc and Lox-Stop-Lox oncogenic Kras(G12D) alleles, respectively, to generate G22Cre; Apc(flox/flox); Kras(G12D) and G22Cre; Apc(flox/flox); KrasWT mice. Gene expression profiles of the tumors were analyzed using high-density oligonucleotide arrays. Morphologically, minimal difference in proximal colon tumor was observed between the two mouse models. Consistent with previous findings in vitro, Glut1 transcript and protein expression was up-regulated in the tumors of G22Cre;Apc (flox/flox) ; Kras(G12D) mice. Immunohistochemical staining analysis revealed that GLUT1 protein expression correlated with KRAS mutations in human colorectal cancer. Microarray analysis identified 11 candidate genes upregulated more than fivefold and quantitative PCR analysis confirmed that Aqp8, Ttr, Qpct, and Slc26a3 genes were upregulated 3.7- to 30.2-fold in tumors with mutant Kras. These results demonstrated the validity of the G22Cre; Apc(flox/flox) ;Kras (G12D) mice as a new mouse model with oncogenic Kras activation. We believe that this model can facilitate efforts to define novel factors that contribute to the pathogenesis of human colorectal cancer with KRAS mutations.

  17. Instability of warped discs

    Science.gov (United States)

    Doǧan, S.; Nixon, C. J.; King, A. R.; Pringle, J. E.

    2018-05-01

    Accretion discs are generally warped. If a warp in a disc is too large, the disc can `break' apart into two or more distinct planes, with only tenuous connections between them. Further, if an initially planar disc is subject to a strong differential precession, then it can be torn apart into discrete annuli that precess effectively independently. In previous investigations, torque-balance formulae have been used to predict where and when the disc breaks into distinct parts. In this work, focusing on discs with Keplerian rotation and where the shearing motions driving the radial communication of the warp are damped locally by turbulence (the `diffusive' regime), we investigate the stability of warped discs to determine the precise criterion for an isolated warped disc to break. We find and solve the dispersion relation, which, in general, yields three roots. We provide a comprehensive analysis of this viscous-warp instability and the emergent growth rates and their dependence on disc parameters. The physics of the instability can be understood as a combination of (1) a term that would generally encapsulate the classical Lightman-Eardley instability in planar discs (given by ∂(νΣ)/∂Σ < 0) but is here modified by the warp to include ∂(ν1|ψ|)/∂|ψ| < 0, and (2) a similar condition acting on the diffusion of the warp amplitude given in simplified form by ∂(ν2|ψ|)/∂|ψ| < 0. We discuss our findings in the context of discs with an imposed precession, and comment on the implications for different astrophysical systems.

  18. System Detects Vibrational Instabilities

    Science.gov (United States)

    Bozeman, Richard J., Jr.

    1990-01-01

    Sustained vibrations at two critical frequencies trigger diagnostic response or shutdown. Vibration-analyzing electronic system detects instabilities of combustion in rocket engine. Controls pulse-mode firing of engine and identifies vibrations above threshold amplitude at 5.9 and/or 12kHz. Adapted to other detection and/or control schemes involving simultaneous real-time detection of signals above or below preset amplitudes at two or more specified frequencies. Potential applications include rotating machinery and encoders and decoders in security systems.

  19. Evaporation and Antievaporation Instabilities

    Directory of Open Access Journals (Sweden)

    Andrea Addazi

    2017-10-01

    Full Text Available We review (antievaporation phenomena within the context of quantum gravity and extended theories of gravity. The (antievaporation effect is an instability of the black hole horizon discovered in many different scenarios: quantum dilaton-gravity, f ( R -gravity, f ( T -gravity, string-inspired black holes, and brane-world cosmology. Evaporating and antievaporating black holes seem to have completely different thermodynamical features compared to standard semiclassical black holes. The purpose of this review is to provide an introduction to conceptual and technical aspects of (antievaporation effects, while discussing problems that are still open.

  20. Resonant Drag Instabilities in protoplanetary disks: the streaming instability and new, faster-growing instabilities

    Science.gov (United States)

    Squire, Jonathan; Hopkins, Philip F.

    2018-04-01

    We identify and study a number of new, rapidly growing instabilities of dust grains in protoplanetary disks, which may be important for planetesimal formation. The study is based on the recognition that dust-gas mixtures are generically unstable to a Resonant Drag Instability (RDI), whenever the gas, absent dust, supports undamped linear modes. We show that the "streaming instability" is an RDI associated with epicyclic oscillations; this provides simple interpretations for its mechanisms and accurate analytic expressions for its growth rates and fastest-growing wavelengths. We extend this analysis to more general dust streaming motions and other waves, including buoyancy and magnetohydrodynamic oscillations, finding various new instabilities. Most importantly, we identify the disk "settling instability," which occurs as dust settles vertically into the midplane of a rotating disk. For small grains, this instability grows many orders of magnitude faster than the standard streaming instability, with a growth rate that is independent of grain size. Growth timescales for realistic dust-to-gas ratios are comparable to the disk orbital period, and the characteristic wavelengths are more than an order of magnitude larger than the streaming instability (allowing the instability to concentrate larger masses). This suggests that in the process of settling, dust will band into rings then filaments or clumps, potentially seeding dust traps, high-metallicity regions that in turn seed the streaming instability, or even overdensities that coagulate or directly collapse to planetesimals.