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Sample records for clinical investigator-subject relationship

  1. The clinical investigator-subject relationship: a contextual approach

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    Resnik David B

    2009-12-01

    Full Text Available Abstract Background The nature of the relationship between a clinical investigator and a research subject has generated considerable debate because the investigator occupies two distinct roles: clinician and scientist. As a clinician, the investigator has duties to provide the patient with optimal care and undivided loyalty. As a scientist, the investigator has duties to follow the rules, procedures and methods described in the protocol. Results and conclusion In this article, I present a contextual approach to the investigator-subject relationship. The extent of the investigator's duty to provide the patient/subject with clinical care can vary from one situation to the next, as a function of several factors, including: the research design, benefits and risks of the research; the subject's reasonable expectations, motivations, and vulnerabilities; the investigator's ability to benefit the subject; and the investigator's prior relationship with the subject. These and other factors need to be considered when determining the clinical investigator's obligations to provide clinical care to human research subjects. In some research contexts, the investigator has extensive clinical obligations to the patient/subject; in others, the investigator has minimal ones.

  2. Research and clinical practice relationship

    Directory of Open Access Journals (Sweden)

    Ashammakhi N

    2008-01-01

    Full Text Available To The Editor: I highly value and greet the authors for their editorial. Many important issues related to medical education and its future in Libya have been discussed in this paper [1]. One important point that has been addressed and I feel deserves attention is the “abnormal” relationship between clinical practice and research in Libya. From discussions with colleagues, this problem somehow has evolved from a misconception about educational and training systems that may have occurred in the past. It may also be related to the lack of attention to research that has long existed in Libya [2,3]. The other aspect, shared with many other developing countries, is the misconception of research as unimportant or a luxury aspect of medicine. When it comes to understanding how a system (including healthcare can be updated and developed, the answer is vague! One important reason is a lack of understanding of the impact that research has on developing methods. In developed countries, research is the main academic distinction that leads to appointments for coveted positions in the system and is an important factor for academic promotion. In Libya, there remain arguments about who will be awarded Chair of university clinical departments. Such a post should no doubt be given to those with established academic achievements. When highly qualified persons are at the top of the pyramid this leads to further progress and enhanced research and advancement. The authors have discussed the point of having proper search committees for leadership and faculty positions. I believe that it will help eliminate the current stagnation and help to create innovative solutions. This should lead to improved medical education, health services, and ultimately impact the quality of life of all Libyan citizens.

  3. Clinical Relationships Extraction Techniques from Patient Narratives

    Directory of Open Access Journals (Sweden)

    Wafaa Tawfik Abdel-Moneim

    2013-01-01

    Full Text Available The Clinical E-Science Framework (CLEF project was used to extract important information from medical texts by building a system for the purpose of clinical research, evidence-based healthcare and genotype-meets-phenotype informatics. The system is divided into two parts, one part concerns with the identification of relationships between clinically important entities in the text. The full parses and domain-specific grammars had been used to apply many approaches to extract the relationship. In the second part of the system, statistical machine learning (ML approaches are applied to extract relationship. A corpus of oncology narratives that hand annotated with clinical relationships can be used to train and test a system that has been designed and implemented by supervised machine learning (ML approaches. Many features can be extracted from these texts that are used to build a model by the classifier. Multiple supervised machine learning algorithms can be applied for relationship extraction. Effects of adding the features, changing the size of the corpus, and changing the type of the algorithm on relationship extraction are examined.

  4. Automatic semantic interpretation of anatomic spatial relationships in clinical text.

    Science.gov (United States)

    Bean, C A; Rindflesch, T C; Sneiderman, C A

    1998-01-01

    A set of semantic interpretation rules to link the syntax and semantics of locative relationships among anatomic entities was developed and implemented in a natural language processing system. Two experiments assessed the ability of the system to identify and characterize physico-spatial relationships in coronary angiography reports. Branching relationships were by far the most common observed (75%), followed by PATH (20%) and PART/WHOLE relationships. Recall and precision scores were 0.78 and 0.67 overall, suggesting the viability of this approach in semantic processing of clinical text.

  5. Clinical Laboratory Stressors Used to Study Alcohol–Stress Relationships

    OpenAIRE

    Thomas, Suzanne; Bacon, Amy K.; Sinha, Rajita; Uhart, Magdalena; Adinoff, Bryon

    2012-01-01

    Understanding the biologic systems that underlie the relationship between stress and alcohol consumption may lead to better prevention efforts and more effective treatments for alcoholism. Clinical laboratory studies offer a unique opportunity to examine these relationships by using a controlled environment to study how an acute stressor affects alcohol drinking and alcohol craving, how individuals in recovery or those at risk for alcoholism may respond differently to stressors relative to co...

  6. [Relationship between residual milk and clinical mastitis in dairy cattle].

    Science.gov (United States)

    Cording, F; Hoedemaker, M; Krömker, V

    2013-01-01

    Mastitis in cattle is an infection of the mammary gland caused by infection, toxins and/or trauma. Currently, it is assumed that there is a correlation between higher amounts of residual milk and the incidence of clinical mastitis. The amount of residual milk can be examined using different methods. Higher amounts of residual milk may result from an insufficient teat condition and individual detachment settings of milking units. To date, scientific literature has already discussed the relationship between high amounts of residual milk, undermilking and the occurrence of clinical mastitis. The present paper reviews the current status of knowledge regarding residual milk and risk of mastitis.

  7. [Relationship of statistics and data management in clinical trials].

    Science.gov (United States)

    Chen, Feng; Sun, Hua-long; Shen, Tong; Yu, Hao

    2015-11-01

    A perfect clinical trial must nave a solid study design, strict conduction, complete quality control, non-interference of statistical result, and acceptable risk-benefit ratio. To reach the target, the quality control (QC) should be performed from the study design to conduction, from the analysis to conclusion. We discuss the relationship between data management and biostatistics from the statistical point of view, and emphasize the importance of the statistical concept and methods in the improvement of data quality in clinical data management.

  8. Clinical laboratory stressors used to study alcohol-stress relationships.

    Science.gov (United States)

    Thomas, Suzanne; Bacon, Amy K; Sinha, Rajita; Uhart, Magdalena; Adinoff, Bryon

    2012-01-01

    Understanding the biologic systems that underlie the relationship between stress and alcohol consumption may lead to better prevention efforts and more effective treatments for alcoholism. Clinical laboratory studies offer a unique opportunity to examine these relationships by using a controlled environment to study how an acute stressor affects alcohol drinking and alcohol craving, how individuals in recovery or those at risk for alcoholism may respond differently to stressors relative to control subjects, and how alcohol differentially affects stress reactivity in these groups. This article reviews some of the most common physical, psychological, and pharmacological stressors used in stress-induction studies designed to reveal details about the relationship between stress reactivity and alcohol use and abuse.

  9. Learning to be a midwife in the clinical environment; tasks, clinical practicum hours or midwifery relationships.

    Science.gov (United States)

    Ebert, Lyn; Tierney, Olivia; Jones, Donovan

    2016-01-01

    Discussions continue within the midwifery profession around the number of and type of clinical experiences required to ensure competent midwifery graduates. Introduction of the three year Bachelor of Midwifery in Australia, almost two decades ago, was intended to reduce the pressure students were under to complete their academic requirements whilst ensuring students developed midwifery practice that encapsulates the philosophical values of midwifery. Currently, midwifery students are mandated to achieve a minimum number of clinical skills and Continuity of Care Experience (CCE) relationships in order to register upon completion of their degree. To achieve these experiences, universities require students to complete a number of clinical practicum hours. Furthermore students are required to demonstrate competent clinical performance of a number of clinical skills. However, there is no evidence to date that a set number of experiences or hours ensures professional competence in the clinical environment. The aim of this paper is to promote discussion regarding the mandated requirements for allocated clinical practicum hours, specified numbers of clinical-based skills and CCE relationships in the context of learning to be a midwife in Australia.

  10. The Relationship between Clinical Competence and Clinical Self-efficacy among Nursing and Midwifery Students

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    Shahla Mohamadirizi

    2015-12-01

    Full Text Available Introduction  Self-efficacy in clinical performance had an important role in applying competencies; also competencies and self-efficacy in clinical performance influenced to quality care of nursing and midwifery students. So the present study aimed to define the relationship between clinical competencies and clinical self-efficacy among nursing and midwifery students. Materials and Methods  This is a cross-sectional study conducted on 150 of nursing and midwifery students in Isfahan University of Medical Science, selected through two stage sampling in 2014. The participant completed questionnaires about personal/ educational characteristics and nursing competencies questionnaire (18 items and clinical self-efficacy scale (37 items. The data were analyzed by, Pearson statistical test, t-test, variance analysis through SPSS version16. Results The results showed that 50% (n=75 and 37.4% (n=56 of nursing and midwifery students had good clinical competence and clinical Self-Efficacy, respectively. Also the mean competencies and self-efficacy in clinical performance scores were 35.05± 1.2 and 76.03± 0.4 respectively. Pearson correlation coefficient showed that there was a positive linear correlation between the score of clinical competence and clinical self-efficacy (P

  11. Relationship of femorodistal bypass patency to clinical outcome. Iloprost Bypass International Study Group

    DEFF Research Database (Denmark)

    Watson, H R; Schroeder, T V; Simms, M H;

    1999-01-01

    To investigate the relationship between bypass patency, limb survival and clinical symptoms after femorodistal bypass procedures.......To investigate the relationship between bypass patency, limb survival and clinical symptoms after femorodistal bypass procedures....

  12. Free amino acids in fibromyalgia syndrome: relationship with clinical picture.

    Science.gov (United States)

    Ruggiero, Valeria; Mura, Massimiliano; Cacace, Enrico; Era, Benedetta; Peri, Marcella; Sanna, Giuseppina; Fais, Antonella

    2017-04-01

    The objectives of our study were to evaluate free amino acid (FAA) concentrations in the serum of patients affected by fibromyalgia syndrome (FMS) and to determine the relationships between FAA levels and FMS clinical parameters. Thus, serum amino acid concentrations were quantified (HPLC analysis) in 23 females with fibromyalgia (according to the American College of Rheumatology classification criteria) and 20 healthy females. The results showed significantly higher serum concentrations of aspartate, cysteine, glutamate, glycine, isoleucine, leucine, methionine, ornithine, phenylalanine, sarcosine, serine, taurine, tyrosine and valine in FMS patients vs. healthy controls. Patients with higher Fibromyalgia Impact Questionnaire (FIQ) scores showed increased levels of alanine, glutamine, isoleucine, leucine, phenylalanine, proline and valine. In conclusion, our results indicate an imbalance in some FAAs in FMS patients. Increased Glu is particularly interesting, as it could explain the deficit in monoaminergic transmission involved in pain.

  13. Clinical Relationship between Steatocholecystitis and Gallbladder Contractility Measured by Cholescintigraphy

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    Chang Seok Bang

    2015-01-01

    Full Text Available Objective. Contractility of gallbladder is known to be decreased in fatty gallbladder diseases. However, clinical estimation data about this relationship is still lacking. The aim of this study was to investigate the association between steatocholecystitis and contractility of gallbladder. Methods. Patients with cholecystitis (steatocholecystitis versus nonsteatocholecystitis who underwent cholescintigraphy before cholecystectomy were retrospectively evaluated in a single teaching hospital of Korea. The association of steatocholecystitis with contractility of gallbladder, measured by preoperative cholescintigraphy, was assessed by univariable and multivariable analysis. Results. A total of 432 patients were finally enrolled (steatocholecystitis versus nonsteatocholecystitis; 75 versus 357, calculous versus acalculous cholecystitis; 316 versus 116. In the multivariable analysis, age (OR: 0.94, 95% CI: 0.90–0.99, P=0.01 and total serum cholesterol (OR: 1.02, 95% CI: 1.01–1.04, P=0.04 were related to steatocholecystitis in patients with acalculous cholecystitis. Only age (OR: 0.97, 95% CI: 0.94–0.99, P=0.004 was significantly related to steatocholecystitis in patients with calculous cholecystitis. However, ejection fraction of gallbladder reflecting contractility measured by cholescintigraphy was not related to steatocholecystitis irrespective of presence of gallbladder stone in patients with cholecystitis. Conclusion. Ejection fraction of gallbladder measured by cholescintigraphy cannot be used for the detection or confirmation of steatocholecystitis.

  14. Relationship Between Histopathology and Clinical Prognosis of Invasive Pituitary Adenoma

    Institute of Scientific and Technical Information of China (English)

    LIYong; SHUKai; DONGFangyong; WANFeng; LEITing; LILing

    2005-01-01

    Objective: To study the relationship between histopathology and clinical prognosis of invasive pituitary adenoma subjected to transsphenoidal surgery. Methods: The enrolled were 82 patients with invasive pituitary adenomas undergoing transsphenoidal surgery during Jan. 2000 May 2003 in our department with full MR imaging findings, pathology data and follow-up information. The follow-up duration was 5-30 months. Results: MR imaging findings of invasive pituitary adenoma included: depression of the sellar floor, involvement of sphenoid sinus and cavernous sinus, breakthrough of diaphragma sellae,encasement of internal carotid artery, etc. Pathological examination revealed that the invasion rate of dura in sella turcica was the highest among the structures around tumor. Pituitary adenoma apoplexy was found in 20 cases (24.4%). The total removal rate for PRL-secreting adenomas was significantly lower than that for non-secreting adenomas (P<0.01), but non-, GH-, ACTH-secreting adenomas had no significant differences. The recurrence rate of PRL-secreting adenornas was higher than that of non- and GH-secreting adenomas (P<0.05). Conclusion: Among invasive pituitary adenomas, the therapeutic effects of nonand GH-secreting pituitary adenomas are better than that of PRL-secreting adenomas. Invasive biological behaviors of invasive pituitary adenomas result in radical operation failure and postoperative recurrence.

  15. Relationship between coronary arterial remodeling and clinical presentation

    Institute of Scientific and Technical Information of China (English)

    杨震坤; 沈卫峰; 张大东

    2003-01-01

    Objective To examine the relationship between coronary arterial remodeling and clinical presentation. Methods A total of 34 patients with acute (10 with recent myocardial infarction and 24 with unstable angina) and 26 with stable (8 with old myocardial infarction and 18 with stable angina) coronary syndrome underwent intravascular ultrasound (IVUS) before intervention. Target lesions were classified as soft or hard plaques. Q uantitative measurements of cross-sectional area (CSA) of external elastic memb rane (EEM), lumen and plaque were performed at the lesion site and at the proxim al and distal reference sites. Remodeling index (RI) was expressed by the ratio of EEM CSA at the lesion site to the mean EEM CSA of both proximal and distal r eference sites. Positive remodeling was defined as RI>1.05 and negative remode ling as RI<0.95. Results Soft plaque was observed more frequently in acute than in stable coronary syndrome (59% vs 31%), whereas hard plaque was more common in stable coronary syndrome (69% vs 41%) (P=0.03). The EEM CSA (15.11±2.89 mm2 vs 13.25±3.10 mm2, P=0.019) and plaque CSA (10.83±2.62 mm2 vs 9.30±2.84 mm 2, P =0.035) were significantly greater at target lesions in patients with acute r ather than stable coronary syndrome, while lumen CSA and percent area stenosis w ere similar in both groups. RI was significantly higher (1.08±0.16 vs 0.95 ±0.14, P=0.002) and positive remodeling was more frequent in acute corona ry syndrome (53% vs 23%, P=0.019), whereas negative remodeling was more com mon in stable coronary syndrome (58% vs 24%, P=0.007). Conclusions The study indicates that clinical characteristics of patients with coronary artery disease depend largely upon underlying types of coronary arterial remodeling .

  16. The relationships between clinical variables and renal parenchymal disease in pediatric clinically suspected urinary tract infection

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    Jung Lim Byun

    2010-02-01

    Full Text Available Purpose : To evaluate the significance of clinical signs and laboratory findings as predictors of renal parenchymal lesions and vesicoureteral reflux (VUR in childhood urinary tract infection (UTI. Methods : From July 2005 to July 2008, 180 patients admitted with a first febrile UTI at the Pediatric Department of Konkuk University Hospital were included in this study. The following were the clinical variables: leukocytosis, elevated C-reactive protein (CRP, positive urine nitrite, positive urine culture, and fever duration both before and after treatment. We evaluated the relationships between clinical variables and dimercaptosuccinic acid (DMSA scan and voiding cystourethrography (VCUG results. Results : VCUG was performed in 148 patients; of them, 37 (25.0% had VUR: 18 (12.2% had low-grade (I-II VUR, and 19 (10.5% had high-grade (III-V VUR. Of the 95 patients who underwent DMSA scanning, 29 (30.5% had cortical defects, of which 21 (63.6% had VUR: 10 (30.3%, low-grade (I-II VUR; and 11 (33.3%, high-grade VUR. Of the 57 patients who were normal on DMSA scan, 8 (14.0% had low-grade VUR and 6 (10.5% had high-grade VUR. The sensitivity, specificity, and positive and negative predictive values of the DMSA scan in predicting high-grade VUR were 64.7%, 69.9%, 33.3%, and 89.5%, respectively. Leukocytosis, elevated CRP, and prolonged fever (?#243;6 hours after treatment were significantly correlated with the cortical defects on DMSA scans and high-grade VUR. Conclusion : Clinical signs, including prolonged fever after treatment, elevated CRP, and leukocytosis, are positive predictors of acute pyelonephritis and high-grade VUR.

  17. Study of the Relationship Between Nurse Self-Concept and Clinical Performance Among Nursing Students

    OpenAIRE

    Badiyepeymaie Jahromi; Kargar; Ramezanli

    2015-01-01

    Background Scholars believe that if nursing students appreciate the value of their services, their sense of professionalism will increase and performance will improve. Nevertheless, little is known about the relationship between nursing students’ professional self-concept and clinical performance. Objectives This study examines the relationship between nurse self-concept and clinical performance among nursing students. ...

  18. Relationship between teat-end callosity and occurrence of clinical mastitis

    NARCIS (Netherlands)

    Neijenhuis, F.; Barkema, H.W.; Hogeveen, H.

    2001-01-01

    A longitudinal study in 15 herds, with a total of 2157 cows, was conducted to examine the relationship between teat-end callosity (TEC) and the incidence of clinical mastitis. During the 1.5-yr study period, clinical mastitis was diagnosed by the farmers based on clinical signs. Teat-end callosity w

  19. Mediators of the Link between Autistic Traits and Relationship Satisfaction in a Non-Clinical Sample

    Science.gov (United States)

    Pollmann, Monique M. H.; Finkenauer, Catrin; Begeer, Sander

    2010-01-01

    People with ASD have deficits in their social skills and may therefore experience lower relationship satisfaction. This study investigated possible mechanisms to explain whether and how autistic traits, measured with the AQ, influence relationship satisfaction in a non-clinical sample of 195 married couples. More autistic traits were associated…

  20. Assessing the Proximity Relationship of Walk-in Clinics and Primary Care Physicians.

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    Chen, Alissa; Revere, Lee; Ramphul, Ryan

    2016-01-01

    This article evaluates the spatial relationship between primary care provider clinics and walk-in clinics. Using ZIP code level data from Harris County, Texas, the results suggest that primary care physicians and walk-in clinics are similarly located at lower rates in geographic areas with populations of lower socioeconomic status. Although current clinic location choices effectively broaden the gap in primary care access for the lower income population, the growing number of newly insured individuals may make it increasingly attractive for walk-in clinics to locate in geographic areas with populations of lower socioeconomic status and less competition from primary care physicians.

  1. Relationship between some clinical situations, autoantibodies, and pseudothrombocytopenia.

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    Isik, Ayse; Balcik, Ozlem Sahin; Akdeniz, Derya; Cipil, Handan; Uysal, Sema; Kosar, Ali

    2012-11-01

    The widespread usage of blood count autoanalyzers has led to a major improvement in cellular hematology because of quick and accurate results found in most instances. However, spurious test results also can be observed like pseudothrombocytopenia (PTCP). In our study, we aimed to evaluate the clinical and laboratory factors associated with PTCP. Forty-six patients with PTCP and 69 healthy volunteers were enrolled in the study. Sex distribution was similar between the groups. Hospitalization, infection, the use of low-molecular-weight heparin and pregnancy increased the incidence of PTCP. Atherosclerosis and some drugs such as warfarin and calcium channel blockers were associated with PTCP, but the coincidence was not statistically significant. Antinuclear antibody positivity was higher in PTCP group (18.8% vs 7.2%; P=0.033) but anticardiolipin positivity rates were similar when compared to controls. Pseudothrombocytopenia was frequently misdiagnosed, which led to inappropiate treatments. Therefore, this situation should be kept in mind.

  2. Relationship between Genomic Types of Escherichia coli and Clinical Diseases

    Institute of Scientific and Technical Information of China (English)

    Meiying YI; Ruen LIU; Hanju HUANG

    2008-01-01

    In this study, by analysis of genome structures of E. coli, the relationships Between the genomic types of E. coli and the associated diseases were investigated. Samples of sputum, urine and other excretions from patients with different infective diseases were collected. And 62 E. coli strains were isolated from these samples. Intact bacterial genomic DNA was cleaved with I-CeuI, separated by pulsed field gel electrophoresis and then typed on the basis of cleavage map. The results showed that 7 I-CeuI sites were found in all the genome structures of the 62 E. coli, indicating that there were 7 rrn operons in the genomes. The size of genome ranged from 4500 kb to 5000 kb. According to thegenome structures, 62 E. coli strains were divided into 30 genome types. It was concluded that genome structures of E. coli isolated from the patients with different infective diseases varied to some extent, suggesting that some genome types of E. coli were closely related to some infective diseases.

  3. Relationship between oral clinical conditions and daily performances

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    Andréa Silveira Gomes

    2009-03-01

    Full Text Available The aim of this study was to assess the impact of oral status on the daily performances of civil servants from the Public Works and Waste Management Department of the city of Porto Alegre, located in Southern Brazil. A cross-sectional study was conducted on a representative sample composed of 276 civil servants with ages ranging from 35 to 44 years. The Oral Impacts on Daily Performances index developed was employed to measure impacts caused by oral clinical conditions. Oral examinations were performed after the interviews. Multinomial Logistic Regression Analysis was used. After adjusting for sex and educational level, the results showed that the subjects with high DMFT scores were 5.8 times (95% CI = 2.1-16.1 more likely to have high impacts on their everyday life than those with low DMFT scores. Subjects that presented some coronal caries were 4.3 times (95% CI = 1.9-9.8 more likely to have high impacts on their everyday life than those with no coronal caries. Dental status assessed through the DMFT index and coronal caries are important indicators of impacts on the everyday life of the studied population.

  4. Reflections on the supervised relationship and interaction in nursing clinical training

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    Inês Alves da Rocha e Silva Rocha

    2013-05-01

    Full Text Available This reflection fits into the area of Clinical Supervision in Nursing focusing on relationships that the student develops during clinical training. It seems that in clinical training the student not only learns but also consolidates verbal, procedural and attitudinal contents. The relationship established with peers, teachers and tutors will contribute to their professional identity. It is underlined the importance of the contribution of clinical supervision for the development of a reflective thinking in students in Portugal, as highlighted here, which influences the changes in nursing practices, as well as ensuring the quality and safety of the care provided. The characteristics that the tutor must have to improve the development of the students are also explained as well as the possible solutions for the existing limitations of clinical training contexts.

  5. Clinical and histopathological features and relationship of Barrett esophagus and its related adenocarcinoma

    Institute of Scientific and Technical Information of China (English)

    陈慧

    2014-01-01

    Objective To explore the clinical and histopathological features of Barrett esophagus and its related adenocarcinoma as well as the relationship between them.Methods From ajanuary 2002 to January 2012,the clinical data of 35 patients with Barrett esophagus,850 patients with esophagus cancer and 218 patients with esophageal-gastric junction cancer were collected,and the histopathological features of all the patients and the followup in patients with Barrett esophagus were retrospectively

  6. Some insights for a relationship marketing model integrating SERVQUAL and customer loyalty in dental clinics

    OpenAIRE

    Vargas Perez, Ana Maria; Grijalvo Martin, Maria Mercedes; Mercado Idoeta, Carmelo

    2012-01-01

    The demand of new services, the emergence of new business models, insufficient innovation, underestimation of customer loyalty and reluctance to adopt new management are evidence of the deficiencies and the lack of research about the relations between patients and dental clinics. In this article we propose the structure of a model of Relationship Marketing (RM) in the dental clinic that integrates information from SERVQUAL, Customer Loyalty (CL) and activities of RM and combines the vision of...

  7. Episiotomy and its relationship to various clinical variables that influence its performance

    OpenAIRE

    Carmen Ballesteros-Meseguer; César Carrillo-García; Mariano Meseguer-de-Pedro; Manuel Canteras-Jordana; Mª Emilia Martínez-Roche

    2016-01-01

    Objective: to understand the episiotomy rate and its relationship with various clinical variables. Method: a descriptive, cross-sectional, analytic study of 12,093 births in a tertiary hospital. Variables: Parity, gestational age, start of labor, use of epidural analgesia, oxytocin usage, position during fetal explusion, weight of neonate, and completion of birth. The analysis was performed with SPSS 19.0. Results: the global percentage of episiotomies was 50%. The clinical variables that p...

  8. A systematic review of the relationship between blood loss and clinical signs.

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    Rodolfo Carvalho Pacagnella

    Full Text Available INTRODUCTION: This systematic review examines the relationship between blood loss and clinical signs and explores its use to trigger clinical interventions in the management of obstetric haemorrhage. METHODS: A systematic review of the literature was carried out using a comprehensive search strategy to identify studies presenting data on the relationship of clinical signs & symptoms and blood loss. Methodological quality was assessed using the STROBE checklist and the general guidelines of MOOSE. RESULTS: 30 studies were included and five were performed in women with pregnancy-related haemorrhage (other studies were carried in non-obstetric populations. Heart rate (HR, systolic blood pressure (SBP and shock index were the parameters most frequently studied. An association between blood loss and HR changes was observed in 22 out of 24 studies, and between blood loss and SBP was observed in 17 out of 23 studies. An association was found in all papers reporting on the relationship of shock index and blood loss. Seven studies have used Receiver Operating Characteristic Curves to determine the accuracy of clinical signs in predicting blood loss. In those studies the AUC ranged from 0.56 to 0.74 for HR, from 0.56 to 0.79 for SBP and from 0.77 to 0.84 for shock index. In some studies, HR, SBP and shock index were associated with increased mortality. CONCLUSION: We found a substantial variability in the relationship between blood loss and clinical signs, making it difficult to establish specific cut-off points for clinical signs that could be used as triggers for clinical interventions. However, the shock index can be an accurate indicator of compensatory changes in the cardiovascular system due to blood loss. Considering that most of the evidence included in this systematic review is derived from studies in non-obstetric populations, further research on the use of the shock index in obstetric populations is needed.

  9. Apathy in Elderly Nondemented Patients With Parkinson's Disease : Clinical Determinants and Relationship to Quality of Life

    NARCIS (Netherlands)

    Skorvanek, Matej; Rosenberger, Jaroslav; Gdovinova, Zuzana; Nagyova, Iveta; Saeedian, Radka Ghorbani; Groothoff, Johan W.; Dijk, Jitse P.

    2013-01-01

    Objectives: To describe the prevalence and clinical determinants of apathy in elderly nondemented patients with Parkinson's disease (PD) and their relationship to quality of life (QoL). Methods: A total of 106 nondemented elderly patients with PD were examined using the Movement Disorder Society-Uni

  10. Relationship between cognition, clinical and cognitive insight in psychotic disorders : A review and meta-analysis

    NARCIS (Netherlands)

    Nair, Akshay; Palmer, Emma Claire; Aleman, Andre; David, Anthony S.

    2014-01-01

    The neurocognitive theory of insight posits that poor insight in psychotic illnesses is related to cognitive deficits in cognitive self-appraisal mechanisms. In this paper we perform a comprehensive meta-analysis examining relationships between clinical insight and neurocognition in psychotic disord

  11. The relationship between nurses’ clinical competence and burnout in neonatal intensive care units

    Science.gov (United States)

    Soroush, Fatemehzahra; Zargham-Boroujeni, Ali; Namnabati, Mahboobeh

    2016-01-01

    Background: Nurses’ clinical competency plays an important role in the care of preterm infants. On the other hand, burnout is one of the most important factors in reducing the nurses’ efficiency. With regard to the importance of the role of nurses, and the vulnerability of the infants, the purpose of this study was to investigate the relationship between nurses’ burnout and clinical competency in NICUs. Materials and Methods: The descriptive cross-sectional study was conducted with the participation of 86 nurses working in the NICUs of hospitals in Isfahan, Iran. Census sampling method was used in the NICUs of educational hospitals in 2014. Data were collected by a questionnaire including demographic characteristics, Patricia clinical competency, and Maslach burnout scales. Data were analyzed by the statistical tests of independent t-test and Pearson correlations test with the significance level of α burnout were assessed at three levels (weak, moderate, and strong levels). Statistical tests showed that clinical competency was at a moderate level in all fields. Of the dimensions of nurses’ burnout, emotional exhaustion was moderate, depersonalization was weak, and personal performance was strong. The results showed that nurses’ burnout and clinical competency in the NICUs were at a moderate level and had a significant negative relationship (r = −0.322, P = 0.003). Conclusions: Results showed that burnout had a negative relationship with competency. Therefore, managers are suggested to improve nurses’ competency and diminish their job burnout through better and more applicable planning. PMID:27563328

  12. Expression of Survivin Gene and Its Relationship with Clinical Multidrug Resistance in Osteosarcoma

    Institute of Scientific and Technical Information of China (English)

    NIETao; DAIMin; ZONGShizhang

    2005-01-01

    Objective: To study the expression of survivin and its relationship with clinical multidrug resistance in osteosarcoma. Methods: By using immunohistochemistry (S-P) method, the expression of Survivin in osteosarcoma, osteochondroma and normal osseous tissue, and the expression of P-glycoprotein in osteosarcoma was detected. Results: Survivin positive expression rate was 65.71% in osteosarcoma, but no expression of Survivin was detectable in osteochondroma and normal osseous tissue. The positive expression rate of Survivin was significantly associated with Enneking clinical stages and histological typing (WHO), but no relationship was found among Survivin expression and age, sex and tumor location. The positive expression rate of P-glycoprotein was 45.71%. There was a significant correlation between Survivin and p-glycoprotein. Conclusion: Survivin overexpression was significantly associated with clinical multidrug resistance in osteosarcoma. It could be a potential target for treatment of osteosarcoma.

  13. The weak relationship between anatomy competence and clinical skills in junior medical students.

    Science.gov (United States)

    Schoeman, Scarpa; Chandratilake, Madawa

    2012-01-01

    In modern curricula, the early integration of anatomy and clinical skills education at undergraduate level is seen as important. However, the direct relationship between medical students' competence in anatomy, and their clinical proficiency during early undergraduate years, has scarcely been studied. In this study, the marks for anatomy and clinical skills of three consecutive cohorts of medical students (n = 538 in total) during their first two years were correlated. The anatomy competence was measured using a new marker, the Anatomy Competence Score (ACS) which was calculated with equal contributions from theory knowledge and its practical and clinical application. Proficiency in clinical skills was determined by OSCE performance marks for stations which examined physical examination and practical procedural skills. The possible compounding effect of students' general academic ability was investigated by using the overall performance mark for each student based on their performance in all subjects over the first two years of the medical curriculum. We found that the correlation between anatomy and clinical skills marks was weak to moderate. However, this correlation was virtually nullified once the effect of academic ability was accounted for. Although these findings suggest that anatomy education does not compliment early clinical education, the lack of complexity of clinical problems used in clinical skills assessments (OSCEs) during the early stages may well be the primary contributing factor to this finding.

  14. The relationship between CAG repeat length and clinical progression in Huntington's disease.

    Science.gov (United States)

    Ravina, Bernard; Romer, Megan; Constantinescu, Radu; Biglan, Kevin; Brocht, Alicia; Kieburtz, Karl; Shoulson, Ira; McDermott, Michael P

    2008-07-15

    The objective of this study was to examine the relationship between CAG repeat length (CAGn) and clinical progression in patients with Huntington's disease (HD). There are conflicting reports about the relationship between CAGn and clinical progression of HD. We conducted an analysis of data from the Coenzyme Q10 and Remacemide Evaluation in Huntington's Disease (CARE-HD) clinical trial. We modeled progression over 30 months on the Unified Huntington's Disease Rating Scale (UHDRS) and supplemental neuropsychological and behavioral tests using multiple linear regression. Mean subject age was 47.9 +/- 10.5 years and mean CAGn was 45.0 +/- 4.1. Multiple linear regression revealed statistically significant associations between CAGn and worsening on several motor, cognitive, and functional outcomes, but not behavioral outcomes. Many effects were clinically important; 10 additional CAG repeats were associated with an 81% increase in progression on the Independence Scale. These associations were not observed in the absence of age adjustment. Age at the time of assessment confounds the association between CAGn and progression. Adjusting for age shows that longer CAGn is associated with greater clinical progression of HD. This finding may account for the variable results from previous studies examining CAGn and progression. Adjusting for CAGn may be important for clinical trials.

  15. The relationship between attachment styles and internalizing or externalizing symptoms in clinical and nonclinical adolescents

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    Fernando Lacasa

    2015-05-01

    Full Text Available Studies regarding the relationship between attachment and psychopathology during adolescence have been performed separately for clinical and nonclinical adolescents and have used different assessment measures, which together might produce a methodological bias that increases the association between attachment and psychopathology. With the aim of avoiding this bias, the present study used identical measures to explore the relationship between attachment styles and internalizing or externalizing symptoms in clinical and nonclinical samples of adolescents. The sample consisted of 258 adolescents, 129 clinical and 129 nonclinical, aged between 14 and 18 years. The adolescents in each sample were matched for age, gender, and socioeconomic status. Attachment was assessed using the CaMir Q-sort, and psychopathological symptoms were assessed by means of the Youth Self Report (YSR. The relationships between attachment and psychopathology were similar for clinical and nonclinical adolescents. A preoccupied attachment style predicted internalizing and externalizing symptoms, somatic complaints, anxious-fearful behavior, verbal aggression, attention-seeking behavior, and thinking problems. Compared to previous studies, this research has made it possible to identify broader, stronger, and more specific associations between preoccupied attachment style and psychopathological symptoms in adolescents.

  16. Study of the Relationship Between Nurse Self-Concept and Clinical Performance Among Nursing Students

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    Badiyepeymaie Jahromi

    2015-09-01

    Full Text Available Background Scholars believe that if nursing students appreciate the value of their services, their sense of professionalism will increase and performance will improve. Nevertheless, little is known about the relationship between nursing students’ professional self-concept and clinical performance. Objectives This study examines the relationship between nurse self-concept and clinical performance among nursing students. Patients and Methods This cross-sectional analytical study employed the census method. The sample comprised 86 senior and junior nursing students at Jahrom university of medical sciences. Nurse self-concept and clinical performance were measured by using the nurses’ self-concept questionnaire (NSCQ, and the 6-dimension scale of nurse performance (6-DSNP, respectively. Results The mean and standard deviation of nurse self-concept and clinical performance scores were 5.46 ± 1.11 and 2.94 ± 1.45, respectively. Nurse self-concept was related to clinical performance (r = 0.24, P = 0.02. Total NSCQ scores were significantly related to four of the 6-DSNP dimensions: planning and evaluation, interpersonal relations and communication, critical care, and leadership. Conclusions Attempts should be made to enhance students’ nurse self-concept during their education. Counseling, improving public respect for nurses, and implementing measures to enhance students’ professional self-concept are essential for improving their performance.

  17. Clinical trials--a brave new partnership: a new doctor-patient working relationship in research.

    Science.gov (United States)

    Thornton, H

    2008-08-01

    An outline of the development of a "brave new partnership" in clinical trials is provided in this specific personal account. This paper was one of several delivered in November 2007 by colleagues deemed to have contributed to the distinguished career of Professor Michael Baum, at a Festschrift convened to honour him. This account describes this strange, new doctor-patient relationship in the research process that we developed, both in our dialogues and in the work of the Consumers' Advisory Group for Clinical Trials (CAG-CT) that we jointly founded. This work formed but one facet of his outstanding contribution to society and academe, in the fields of medicine, ethics and science.

  18. The European "clinical trial" regulation; relationship with the Jardé Act: a Giens workshop.

    Science.gov (United States)

    Lemaire, François; Marchenay, Brigitte; Chassany, Olivier; Barthélémy, Philippe; Bouzzagou, Mohamed; Comet, Denis; Delval, Cécile; Dubray, Claude; Fouret, Cécile; Frija-Orvoen, Elisabeth; Gambotti, Laetitia; Lamarque, Véronique; d'Orsay, Geneviève; Plattner, Valérie; Sibenaler, Claire; Roux, Jacques; Thoby, Frédérique

    2015-01-01

    In May 2014, the European Union Parliament and Council published a new regulation on clinical trials on medicinal products for human use, which is designed to replace Directive 2001/20/EC. It will not come into effect until 2016. Nevertheless, it is essential to examine its relationship with national legislation, i.e. the Jardé Act, whose implementation has been delayed pending publication of the European regulation. The Giens workshop identified and examined the various issues that this relationship is bound to raise. In particular, it looked at trial methodology assessment procedures, the working relationship between the French National Agency of Drug Safety and Health Products (Agence Nationale de Sécurité du Médicament et des Produits de Santé, ANSM) and ethics committees during the authorization application evaluation phase, review of post-authorization/registration studies on medicinal products and medical devices, and data transparency.

  19. Assessing the relationship between patient satisfaction and clinical quality in an ambulatory setting.

    Science.gov (United States)

    Bosko, Tawnya; Wilson, Kathryn

    2016-10-10

    Purpose The purpose of this paper is to assess the relationship between patient satisfaction and a variety of clinical quality measures in an ambulatory setting to determine if there is significant overlap between patient satisfaction and clinical quality or if they are separate domains of overall physician quality. Assessing this relationship will help to determine whether there is congruence between different types of clinical quality performance and patient satisfaction and therefore provide insight to appropriate financial structures for physicians. Design/methodology/approach Ordered probit regression analysis is conducted with overall rating of physician from patient satisfaction responses to the Clinician and Groups Consumer Assessment of Healthcare Providers and Systems survey as the dependent variable. Physician clinical quality is measured across five composite groups based on 26 Healthcare Effectiveness Data and Information Set (HEDIS) measures aggregated from patient electronic health records. Physician and patient demographic variables are also included in the model. Findings Better physician performance on HEDIS measures are correlated with increases in patient satisfaction for three composite measures: antibiotics, generics, and vaccination; it has no relationship for chronic conditions and is correlated with decrease in patient satisfaction for preventative measures, although the negative relationship for preventative measures is not robust in sensitivity analysis. In addition, younger physicians and male physicians have higher satisfaction scores even with the HEDIS quality measures in the regression. Research limitations/implications There are four primary limitations to this study. First, the data for the study come from a single hospital provider organization. Second, the survey response rate for the satisfaction measure is low. Third, the physician clinical quality measure is the percent of the physician's relevant patient population that met

  20. Functional capacity of Brazilian patients with Parkinson's disease (PD): relationship between clinical characteristics and disease severity.

    Science.gov (United States)

    Barbieri, Fabio A; Rinaldi, Natalia M; Santos, Paulo Cezar R; Lirani-Silva, Ellen; Vitório, Rodrigo; Teixeira-Arroyo, Cláudia; Stella, Florindo; Gobbi, Lilian Teresa B

    2012-01-01

    The present study had three objectives: (a) to characterize the functional capacity of patients with PD, (b) to assess the relationship between the physical fitness components of functional capacity with clinical characteristics and disease severity, and (c) to compare the physical fitness components of functional capacity with clinical characteristics according to disease severity. The study included 54 patients with idiopathic PD who were distributed into two groups according to PD severity: unilateral group (n=35); and bilateral group (n=19). All patients underwent psychiatric assessment by means of the Hoehn and Yahr (HY) staging of PD, the Unified Parkinson's Disease Rating Scale (UPDRS), the Hospital Anxiety and Depression Scale (HADS-A and HADS-D, respectively), and The Mini-Mental State Examination (MMSE). The physical fitness components of functional capacity were evaluated over a 2-day period, using recommendations by the American Alliance for Health, Physical Education, Recreation and Dance, and the Berg Balance Scale (BBS). Pearson correlation coefficients and multiple regressions were calculated to test the correlation between functional capacity and clinical characteristics, and to predict clinical scores from physical performance, respectively. Clinical variables and physical component data were compared between groups using analysis of variance to determine the effects of disease severity. Patients with advanced disease showed low levels of functional capacity. Interestingly, patients with good functional capacity in one of the physical fitness components also showed good capacities in the other components. Disease severity is a major factor affecting functional capacity and clinical characteristics. Medical providers should take disease severity into consideration when prescribing physical activity for PD patients, since the relationship between functional capacity and clinical characteristics is dependent on disease severity.

  1. Relationship between radiological grading and clinical status in knee osteoarthritis. a multicentric study

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    Hernández-Vaquero Daniel

    2012-10-01

    Full Text Available Abstract Background Controversy exists regarding the relationship between radiographic findings and clinical status in knee osteoarthritis. Although the surgical indication for total knee arthroplasty (TKA should be based on pain, clinical status, and the deterioration of quality of life, the radiographic study is the most commonly used criterion for preoperative evaluation. The objective of this study is to find out the relationship between the Ahlbäck classification and clinical status in patients undergoing TKA. Methods 1329 protocols were collected from preoperative studies in four multicentric working groups (the Interax, Duracon, Scorpio, and Triathlon Spanish groups in 30 Spanish hospitals. Mean age was 70.4 years (SD: 6.8; range: 35 to 98; 76.3% of patients were women. Patients entered the study whenever the surgeon found that medical treatment was insufficient to control pain and functional limitation. Data were collected using electronic Case Report Forms, and included Ahlbäck grading scores, Hospital for Special Surgery Knee Score (HSS, SF-12, and other clinical and epidemiologic variables. Results According to the Ahlbäck grading system, patients were divided as follows: 243 grade I (18.3%, 358 grade II (26.9%, 416 grade III (31.3%, 241 grade IV (18.1%, and 71 grade V (5.3%. As for HSS, the following scores were obtained: Conclusions We found a relationship between Ahlbäck grading and the preoperative clinical score. The range of variability of the HSS score between the different Ahlbäck grades is small.

  2. Attachment style and its relationship to working alliance in the supervision of British clinical psychology trainees.

    Science.gov (United States)

    Dickson, Joanne M; Moberly, Nicholas J; Marshall, Yehuda; Reilly, James

    2011-01-01

    Although the supervisory relationship is thought to be critical in training clinical psychologists, little is known about factors affecting the supervisory alliance. We conducted an Internet survey of British clinical doctoral trainees (N = 259) in which participants rated their supervisory working alliance, parental style during childhood, pathological adult attachment behaviours and attachment style for themselves and their supervisors. Trainees' ratings of the working alliance were associated with perceptions of supervisors' attachment style, but not with perceptions of trainees' own attachment styles. Path analysis supported a causal chain linking parental indifference, compulsive self-reliance, insecure supervisor attachment style and lower ratings of the working alliance. Our results broadly replicate data from a US sample and suggest that attachment theory is helpful in understanding clinical supervisory processes.

  3. Advances in imaging-genetic relationships for Alzheimer's disease: clinical implications.

    Science.gov (United States)

    Bagnoli, Silvia; Piaceri, Irene; Sorbi, Sandro; Nacmias, Benedetta

    2014-01-01

    Alzheimer's disease (AD) is the most common cause of dementia and represents a major public health problem. From a clinical perspective, AD is devastating to patients and their families. The genetic approach to the study of dementia undoubtedly continues to provide a significant contribution to understanding the pathogenesis, diagnosis and therapeutic perspectives, but also raises important ethical implications. With advances in new technology, including genetics and PET/MRI scanning, the role of genetic studies and neuroimaging is being redefined as an aid in the clinical diagnosis of AD, and also in presymptomatic evaluation. Here, we review some of the issues related to the neuroimaging-genetic relationship in AD with a possible clinical implication as a preclinical biomarker for dementia and also for tracking disease progression.

  4. What is the relationship between emotional intelligence and dental student clinical performance?

    Science.gov (United States)

    Victoroff, Kristin Zakariasen; Boyatzis, Richard E

    2013-04-01

    Emotional intelligence has emerged as a key factor in differentiating average from outstanding performers in managerial and leadership positions across multiple business settings, but relatively few studies have examined the role of emotional intelligence in the health care professions. The purpose of this study was to examine the relationship between emotional intelligence (EI) and dental student clinical performance. All third- and fourth-year students at a single U.S. dental school were invited to participate. Participation rate was 74 percent (100/136). Dental students' EI was assessed using the Emotional Competence Inventory-University version (ECI-U), a seventy-two-item, 360-degree questionnaire completed by both self and other raters. The ECI-U measured twenty-two EI competencies grouped into four clusters (Self-Awareness, Self-Management, Social Awareness, and Relationship Management). Clinical performance was assessed using the mean grade assigned by clinical preceptors. This grade represents an overall assessment of a student's clinical performance including diagnostic and treatment planning skills, time utilization, preparation and organization, fundamental knowledge, technical skills, self-evaluation, professionalism, and patient management. Additional variables were didactic grade point average (GPA) in Years 1 and 2, preclinical GPA in Years 1 and 2, Dental Admission Test academic average and Perceptual Ability Test scores, year of study, age, and gender. Multiple linear regression analyses were conducted. The Self-Management cluster of competencies (b=0.448, pemotional self-control, achievement orientation, initiative, trustworthiness, conscientiousness, adaptability, and optimism. In this sample, dental students' EI competencies related to Self-Management were significant predictors of mean clinical grade assigned by preceptors. Emotional intelligence may be an important predictor of clinical performance, which has important implications for

  5. ANALYSIS OF OBSERVED BEHAVIORS DISPLAYED BY DEPRESSED-PATIENTS DURING A CLINICAL INTERVIEW - RELATIONSHIPS BETWEEN BEHAVIORAL-FACTORS AND CLINICAL CONCEPTS OF ACTIVATION

    NARCIS (Netherlands)

    BOUHUYS, AL; JANSEN, CJ; VANDENHOOFDAKKER, RH

    1991-01-01

    In 61 drug-free depressed patients, relationships were studied between observed behaviors and measures of common clinical concepts of activation. The behaviors were observed during a clinical interview and analyzed with ethological methods. Activation was assessed by means of self-ratings (Thayer, A

  6. Structural and biomechanical aspects of equine sacroiliac joint function and their relationship to clinical disease.

    Science.gov (United States)

    Goff, L M; Jeffcott, L B; Jasiewicz, J; McGowan, C M

    2008-06-01

    Pain originating from the sacroiliac joint (SIJ) in horses has long been associated with poor performance, yet specific diagnosis of sacroiliac dysfunction (SID) has been difficult to achieve. Clinical presentation of SID appears to fall into two categories. The first, presenting as pain and poor performance, is responsive to local analgesia of periarticular structures with poorly defined pathology. The second presents primarily as poor performance with bony pathological changes as a result of chronic instability. Diagnostic tests based on biomechanics as well as manual provocation for SIJ pain have formed the basis of tests currently used to diagnose SIJ dysfunction in humans. This review summarises the anatomy and biomechanics of the equine SIJ and current biomechanical, innervation and motor control concepts in human SID. The relationship between abnormal SIJ motion and altered neuromotor control with clinical disease of the equine SIJ are discussed. Future utilisation of these principles to develop new diagnostic and management tools for the equine SID is promising.

  7. Relationship between serial CT findings and clinical course of purulent meningitis

    Energy Technology Data Exchange (ETDEWEB)

    Nakata, Mihoko; Nakata, Hajime; Kawanami, Takashi; Fukuda, Miho

    1984-11-01

    We reviewed the CT examinations and clinical records of 31 patients of purulent meningitis to evaluate the relation of CT findings to pathogenic bacteria and clinical course. The most frequently observed abnormal CT finding was an enlargement of the subarachnoid space and ventricles. There was no relationship between those abnormal CT findings and pathogenic bacteria. Enlargement of ventricles, low density area of the white matter and subdural effusion suggested the necessity of the surgical treatment or poor prognosis. The patients with convulsion or re-elevation of CRP had a tendency to show an exacerbation of such abnormalities. On the contrary, abnormal CT findings improved in the patients without convulsion or with decrease of CRP. We conclude that a follow-up CT examination is indicated in cases developing convulsion or re-elevation of CRP. (author).

  8. The Relationship between Clinical and Chemical Hyperandrogenism in 14-18-Years- Old Girls

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    Tahereh Naderi

    2012-04-01

    Full Text Available Background: One of the most common endocrine disorders in women's medicine is the increased androgen and the symptoms of increased androgens in women such as polycystic ovary syndrome. The two main components to diagnose this syndrome are menstrual disorder and clinical or laboratory hyperandrogenism, but other causes should be ruled out in order to confirm the diagnosis. This study aims to examine clinical Hyperandrogenism in female students of 14 to 18 years old in Shiraz in 2010.Materials and Methods: This cross-sectional study was conducted on 3200 female high school students of 14-18 years old in Shiraz. Data collection tools include questionnaires containing personal details, clinical Hyperandrogenism features (acne, alopecia and hirsutism based on Freeman-Galway scale and test results. The ultrasound was conducted based on Adams criteria. The data results are analyzed using SPSS-15 software and χ2 and t statistical tests.Results: : In this study, the frequency of hirsutism is 3.2%, prevalence of acne is 5% and alopecia is 4.2%. Mean of free testosterone (1.647±0.835 was higher in the group with hirsutism, acne and alopecia. Independent t-test showed no significant relationship between patients with hirsutism, acne and alopecia and non-affected people in terms of mean of total testosterone and free testosterone. However, there is a significant relationship between people with acne and hirsutism and polycystic ovary compared with those with acne and hirsutism and those without polycystic ovary (p >0.05..Conclusion: This study indicated that clinical and chemical hyperandrogenism can be a criterion to diagnose with polycystic ovary syndrome, but ultrasound was not helpful.

  9. Relationship between Helicobacter pylori virulence factors and regulatory cytokines as predictors of clinical outcome

    Science.gov (United States)

    Serrano, Carolina; Diaz, Maria Ines; Valdivia, Alejandra; Godoy, Alex; Peña, Alfredo; Rollan, Antonio; Kirberg, Arturo; Hebel, Eduardo; Fierro, Jaqueline; Klapp, Gerardo; Venegas, Alejandro; Harris, Paul R.

    2013-01-01

    H. pylori infection is highly prevalent in Chile (73%). Usually a minority of infected patients develops complications such as ulcers and gastric cancer that have been associated with the presence of virulence factors (cagA, vacA) and host T helper response (Th1/Th2). Our aim was to evaluate the relationship between strain virulence and host immune response, using a multiple regression approach for the development of a model based on data collected from H. pylori infected patients in Chile. We analyzed levels of selected cytokines determined by ELISA (IL-12, IL-10, IFN-γ and IL-4) and the presence of cagA and vacA alleles polymorphisms determined by PCR in antral biopsies of 41 patients referred to endoscopy. By multiple regression analysis we established a correlation between bacterial and host factors using clinical outcome (gastritis and duodenal ulcer) as dependent variables. The selected model was described by: clinical outcome = 0.867491 (cagA) + 0.0131847 (IL-12/IL-10) + 0.0103503 (IFN-γ/IL-4) and it was able to explain over 90% of clinical outcomes observations (R2=96.4). This model considers that clinical outcomes are better explained by the interaction of host immune factors and strain virulence as a complex and interdependent mechanism. PMID:17336120

  10. Relationship between clinical and pathologic findings in patients with chronic liver diseases

    Institute of Scientific and Technical Information of China (English)

    Lun-Gen Lu; Jun Ye; Xiong Cai; Cheng-Wei Chen; Ji-Yao Wang; Shan-Ming Wu; Jin-Shui Zhu; Xia-Qiu Zhou; Min-De Zeng; Yi-Min Mao; Ji-Qiang Li; De-Kai Qiu; Jing-Yuan Fang; Ai-Ping Cao; Mo-Bin Wan; Cheng-Zhong Li

    2003-01-01

    AIM: To explore the relationship between clinical findings of patients with chronic liver diseases and the pathologic grading and staging of liver tissues.METHODS: The inflammatory activity and fibrosis of consecutive liver biopsies from 200 patients were determined according to the diagnosis criteria of chronic hepatitis in China established in 1995. A comparative analysis was carried out for 200 patients with chronic liver diseases by comparing their clinical manifestations, serum biochemical markers with the grading and staging of liver tissues.RESULTS: It was revealed that age, index of clinical symptoms and physical signs were obviously relevant to the pathologic grading and staging of liver tissues (P<0.05). Blood platelet, red blood cells, aspartate aminotransferase (AST),N-terminal procollagen Ⅲ (PⅢ NP) were apparently correlated with the degree of inflammation. PGA (prothrombin time,GGT, apoprotein A1) index, PGAA (PGA+△2-macroglobublin)index, albumin and albumin/globulin were relevant to both inflammation and fibrosis. Hyaluronic acid (HA) was an accurate variable for the severity of hepatic inflammation and fibrosis. The combination of serum markers for fibrosis could increase the diagnostic accuracy. It was notable that viral replication markers were not relevant to the degree of inflammation and fibrosis.CONCLUSION: There is a good correlation between clinical findings and the pathologic grading and staging of liver tissues, which may give aid to the noninvasive diagnosis of liver fibrosis.

  11. Relationship between Gram negative enteric rods, Aggregatibacter actinomycetemcomitans, and clinical parameters in periodontal disease

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    Carlos M Ardila

    2012-01-01

    Full Text Available Background: The association between Gram negative enteric rods and Aggregatibacter actinomycetemcomitans in periodontal diseases has received little attention in the literature. The objective of this study was to explore the relationship between these organisms and clinical parameters of periodontal disease. Materials and Methods: Clinical parameters and occurrence of Gram-negative enteric rods and A. actinomycetemcomitans were examined in 76 patients with chronic periodontitis. Chi-square and Mann-Whitney tests were used to determine differences in clinical variables versus the presence or absence of both microorganisms. Correlation among both organisms and clinical data were determined using Spearman rank correlation coefficient. Results: Gram-negative enteric rods and A. actinomycetemcomitans were detected in 20 (26.3% and 18 (23.7% individuals, respectively. A total of 14 (18.4% patients harbored both microorganisms studied. There were significantly positive correlations between enteric rods and presence of A. actinomycetemcomitans (r=0.652, P<0.0001. Both microorganisms were significant and positively correlated with probing depth (PD, clinical attachment level, and bleeding on probing (P<0.0001. The mean PD (mm of the sampled sites was significantly deeper in patients with presence of A. actinomycetemcomitans and Gram-negative enteric rods. Conclusion: The results of the present study suggest a strong positive correlation between Gram-negative enteric rods and A. actinomycetemcomitans in the population studied. This finding must be taken into account when considering the best therapeutic approach, including the utilization of antimicrobials. The adverse clinical outcomes observed in presence of these microorganisms could have implications in the pathogenesis of periodontal disease and a possible impact on outcomes after treatment.

  12. Relationship between ABO blood groups and malaria with clinical outcome in rural area of South India

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    Gayathri B.N.

    2013-05-01

    Full Text Available Background A number of studies have shown that susceptibility to several infectious diseases is related to the patient’s blood group. Although the relationship between blood group and susceptibility to malaria has been studied by several researchers, the results have been contradictory. Since malaria has re-emerged as a major problem in India during the past few years, it would be useful to know whether there is any relationship between blood group and infection. Objectives The study will be undertaken to correlate the blood groups and clinical presentations in malaria patients and to understand the differential host susceptibility in malaria. Method Over a period of 4 years malaria positive samples identified by peripheral smear (thin and thick smears will be evaluated in this study. Haemoglobin, total leucocyte count, differential leucocyte count and platelet count of each patient done on an automated cell counter will be retrieved from the data. Blood group was determined by forward and reverse method. The demographic details of the patients and clinical details were obtained from case records of the patients. Malarial species and the severity of clinical course were correlated with blood groups Results A total of 205 patients were included in the study, of which 123 cases were positive for plasmodium falciparum and 78 cases were positive for P. vivax infection and 4 patients had mixed infection. The results of blood groups showed 33 -‘A’ group, 84 -‘B’ group, 70 -‘O’ group and 18 were ‘AB’ group. When the clinical courses between different groups were compared using the following parameters for severe infection- a parasitic load of > 10/1000 RBCs, severe anemia with haemoglobin 101o F and the other organ involvement, it was observed that there was no significant relationship between ABO blood group and malaria in our population, this could be due to various demographic reasons. Conclusions The present study indicate that

  13. The relationships between preoperative urodynamic parameters and clinical outcomes in urinary stress incontinence

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    Yaşar Bozkurt

    2008-12-01

    Full Text Available The aim of present study was to evaluate the influence of urodynamic parameters on preoperative and postoperative clinical pictures in stress incontinence.Charts of patients, who were operated for stress incontinence using autologous rectus fascia sling between March 1999 and January 2005 in Tepecik Training and Research Hospital Urology Clinic, were evaluated retrospectively.A total of 41 patients were divided into two subgroups as, pure (10 patients and mixed stress incontinence (31 patients groups. Mean age of patients was 50.4 (33-70 years. Fifteen patients had intrinsic sphincter insufficiency (ISI. Mixed incontinence group had lower volume for first sensation and more detrusor overactivity than pure group. ISI did not alter the success of operation. Urodynamically no relationship was found between detrusor pressure and postoperative postvoiding residual urine (P>0.05.In conclusion, urodynamic evaluation before surgery was not related to preoperative and postoperative clinical picture of patients, but first sensation of bladder is only predictive for the success in fascial sling surgery.

  14. Mediating effect of self-efficacy in relationship between emotional intelligence and clinical communication competency of nurses

    OpenAIRE

    B. Zhu; C.-R. Chen; Z.-Y. Shi; H.-X. Liang; Liu, B.

    2016-01-01

    Objective: This study investigates the emotional intelligence (EI), self-efficacy, and clinical communication ability of clinical nurses to explore the correlation among these three variables, and verify the mediating effect of self-efficacy on relationship between EI and communication skills. Methods: A total of 865 nurses were recruited and investigated using Wong and Law's Emotional Intelligence Scale, General Self-Efficacy Scale, and nurse clinical communication scale. Results: The ...

  15. Prevalence of herpesviruses in gingivitis and chronic periodontitis: relationship to clinical parameters and effect of treatment

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    Rucha Shah

    2016-01-01

    Full Text Available Background: Assess the prevalence of herpesviruses in healthy subjects, gingivitis, and chronic periodontitis patients, to assess the relationship between the prevalence of herpesviruses and periodontal clinical parameters, and to evaluate the effect of phase-I therapy on the level of viral detection. Materials and Methods: Hundred patients consisting of 20 healthy subjects, 40 gingivitis, and 40 chronic periodontitis were included in the study. Clinical parameters recorded included plaque index, gingival index, sulcus bleeding index, probing depth, and clinical attachment level. The gingivitis and chronic periodontitis patients received phase-I periodontal therapy including oral hygiene instructions, full mouth scaling for gingivitis patients and scaling and root planing for chronic periodontitis patients. Gingival crevicular fluid (GCF was collected, and the presence of herpes simplex virus-1 (HSV-1, HSV-2, cytomegalovirus, and Epstein–Barr virus (EBV was analyzed using polymerase chain reaction (PCR. Recording of periodontal parameters as well as GCF collection was performed at baseline and 6 weeks postphase-I therapy. Results: At baseline, the levels of HSV-1 and EBV detection were lower in healthy controls as compared to gingivitis (P < 0.05 and chronic periodontitis cases (P < 0.001. Phase-I therapy led to reduction in the amount of HSV-1 and EBV in gingivitis patients (P < 0.05 and for HSV-1, human cytomegalovirus and EBV in chronic periodontitis patients (P < 0.05 in comparison to baseline. The prevalence of EBV in chronic periodontitis patients was positively associated with increased gingival index, probing depth and loss of clinical attachment (P < 0.05. Conclusions: Higher prevalence of HSV-1 and EBV viruses in GCF of gingivitis and chronic periodontitis suggests a strong association between these viruses and periodontal diseases and periodontal therapy can lead to a reduction in herpesviruses at infected sites.

  16. Leishmania isoenzyme polymorphisms in Ecuador: Relationships with geographic distribution and clinical presentation

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    Mimori Tatsuyuki

    2006-09-01

    Full Text Available Abstract Background Determinants of the clinical presentation of the leishmaniases are poorly understood but Leishmania species and strain differences are important. To examine the relationship between clinical presentation, species and isoenzyme polymorphisms, 56 Leishmania isolates from distinct presentations of American tegumentary leishmaniasis (ATL from Ecuador were analyzed. Methods Isolates were characterized by multilocus enzyme electrophoresis for polymorphisms of 11 isoenzymes. Patients were infected in four different ecologic regions: highland and lowland jungle of the Pacific coast, Amazonian lowlands and Andean highlands. Results Six Leishmania species constituting 21 zymodemes were identified: L. (Viannia panamensis (21 isolates, 7 zymodemes, L. (V. guyanensis (7 isolates, 4 zymodemes, L. (V. braziliensis (5 isolates, 3 zymodemes, L. (Leishmania mexicana (11 isolates, 4 zymodemes, L. (L. amazonensis (10 isolates, 2 zymodemes and L. (L. major (2 isolates, 1 zymodeme. L. panamensis was the species most frequently identified in the Pacific region and was associated with several clinical variants of cutaneous disease (CL; eight cases of leishmaniasis recidiva cutis (LRC found in the Pacific highlands were associated with 3 zymodemes of this species. Mucocutaneous leishmaniasis found only in the Amazonian focus was associated with 3 zymodemes of L. braziliensis. The papular variant of CL, Uta, found in the Andean highlands was related predominantly with a single zymodeme of L. mexicana. Conclusion Our data show a high degree of phenotypic variation within species, and some evidence for associations between specific variants of ATL (i.e. Uta and LRC and specific Leishmania zymodemes. This study further defines the geographic distribution of Leishmania species and clinical variants of ATL in Ecuador.

  17. Relationship between the iceA gene of Helicobacter pylori and clinical outcomes

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    Huang XJ

    2016-07-01

    Full Text Available Xiaojun Huang,1,2 Zhaomin Deng,1 Qiang Zhang,1 Wanyi Li,1 Baoning Wang,1 Mingyuan Li1,3 1Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, People’s Republic of China; 2Department of Microbiology, School of Medicine, Hubei University for Nationalities, Enshi, People’s Republic of China; 3State Key Laboratory of Oral Diseases, Chengdu, People’s Republic of China Background: The complex pathogenesis of Helicobacter pylori (H. pylori and the features of the host influence the diverse clinical outcomes. A mass of studies about virulence genes have accelerated the exploration of pathogenesis of H. pylori infection. Induced by contact with epithelium gene A (iceA is one of the biggest concerned virulence genes. In this study, we explored the relationship between iceA and the magnitude of the risk for clinical outcomes and the prevalence of iceA-positive H. pylori in People’s Republic of China and other countries.Methods: We searched the electronic databases of PubMed, Embase, CNKI, VIP, and Wanfang by literature search strategy. The studies conforming to the inclusion criteria were assessed. With these data, we systematically analyzed the relationship between the iceA gene of H. pylori and clinical outcomes.Results: Nineteen articles with 22 studies, a total of 2,657 cases, were involved in the study. The iceA1 gene was significantly associated with peptic ulcer disease (odds ratio =1.28, 95% confidence interval =1.03–1.60; P=0.03, especially in People’s Republic of China (odds ratio =1.40, 95% confidence interval =1.07–1.83; P=0.01. Moreover, the prevalence of iceA1 was significantly higher than iceA2 in People’s Republic of China (P<0.0001. The prevalence of both iceA1 and iceA2 was significantly different (P<0.0001 in People’s Republic of China and in other countries.Conclusion: The system analysis showed that infection with the iceA1-positive H. pylori significantly

  18. Neuroleptic-induced catatonia: clinical presentation, response to benzodiazepines, and relationship to neuroleptic malignant syndrome.

    Science.gov (United States)

    Lee, Joseph W Y

    2010-02-01

    Neuroleptic-induced catatonia (NIC), manifested in an extrapyramidal-catatonic syndrome, has been sporadically reported in the literature. Confusion surrounds its relationship to neuroleptic malignant syndrome (NMS) and extrapyramidal reactions to neuroleptics. This study examined (a) its clinical presentation and response to benzodiazepines, (b) the hypothesis that NIC and NMS are on the same spectrum with a continuum of symptom progression, and (c) its possible relationship to extrapyramidal reactions. Of 127 episodes of acute catatonia prospectively identified, 18 were diagnosed with NIC. All catatonia episodes received benzodiazepines. The NIC episodes were analyzed noting their clinical presentations, laboratory findings, and responses to treatments. Their responses to benzodiazepines were compared, with retrospective rating on a 7-point scale, to that for catatonia episodes associated with mania and schizophrenia. The progression of symptoms in each NIC episode was reviewed. The NIC episodes presented predominantly in the stuporous form associated with parkinsonism. Delirium, autonomic abnormality, and elevated serum creatine phosphokinase were all common. Neuroleptic malignant syndrome was diagnosed in 3 episodes (17%). The 3 catatonia groups did not differ significantly in their benzodiazepines responses: 78% (14/18) of NIC, 75% (12/16) of manic catatonia, and 67% (34/51) of schizophrenic catatonia episodes showed full responses. A spectrum of presentation across episodes was noted with simple NIC without delirium, autonomic disturbances, or fever at one end and NMS or malignant NIC at the other end. Symptoms in individual episodes showed a similar continuum progression. No extrapyramidal reactions immediately preceded the NIC episodes. Findings of this study support the hypothesis that NIC and NMS are disorders on the same spectrum and reveal no indication that extrapyramidal reactions progress to NIC.

  19. Episiotomy and its relationship to various clinical variables that influence its performance

    Science.gov (United States)

    Ballesteros-Meseguer, Carmen; Carrillo-García, César; Meseguer-de-Pedro, Mariano; Canteras-Jordana, Manuel; Martínez-Roche, Mª Emilia

    2016-01-01

    Objective: to understand the episiotomy rate and its relationship with various clinical variables. Method: a descriptive, cross-sectional, analytic study of 12,093 births in a tertiary hospital. Variables: Parity, gestational age, start of labor, use of epidural analgesia, oxytocin usage, position during fetal explusion, weight of neonate, and completion of birth. The analysis was performed with SPSS 19.0. Results: the global percentage of episiotomies was 50%. The clinical variables that presented a significant association were primiparity (RR=2.98), gestational age >41 weeks (RR=1.2), augmented or induced labor (RR=1.33), epidural analgesia use (RR=1,95), oxytocin use (RR=1.58), lithotomy position during fetal expulsion (RR=6.4), and instrumentation (RR=1.84). Furthermore, maternal age ≥35 years (RR=0.85) and neonatal weight <2500 g (RR=0.8) were associated with a lower incidence of episiotomy. Conclusions: episiotomy is dependent on obstetric interventions performed during labor. If we wish to reduce the episiotomy rate, it will be necessary to bear in mind these risk factors when establishing policies for reducing this procedure. PMID:27224064

  20. Episiotomy and its relationship to various clinical variables that influence its performance

    Directory of Open Access Journals (Sweden)

    Carmen Ballesteros-Meseguer

    2016-01-01

    Full Text Available Objective: to understand the episiotomy rate and its relationship with various clinical variables. Method: a descriptive, cross-sectional, analytic study of 12,093 births in a tertiary hospital. Variables: Parity, gestational age, start of labor, use of epidural analgesia, oxytocin usage, position during fetal explusion, weight of neonate, and completion of birth. The analysis was performed with SPSS 19.0. Results: the global percentage of episiotomies was 50%. The clinical variables that presented a significant association were primiparity (RR=2.98, gestational age >41 weeks (RR=1.2, augmented or induced labor (RR=1.33, epidural analgesia use (RR=1,95, oxytocin use (RR=1.58, lithotomy position during fetal expulsion (RR=6.4, and instrumentation (RR=1.84. Furthermore, maternal age ≥35 years (RR=0.85 and neonatal weight <2500 g (RR=0.8 were associated with a lower incidence of episiotomy. Conclusions: episiotomy is dependent on obstetric interventions performed during labor. If we wish to reduce the episiotomy rate, it will be necessary to bear in mind these risk factors when establishing policies for reducing this procedure.

  1. Relationship of Cognition to Clinical Response in First-Episode Schizophrenia Spectrum Disorders.

    Science.gov (United States)

    Trampush, Joey W; Lencz, Todd; DeRosse, Pamela; John, Majnu; Gallego, Juan A; Petrides, Georgios; Hassoun, Youssef; Zhang, Jian-Ping; Addington, Jean; Kellner, Charles H; Tohen, Mauricio; Burdick, Katherine E; Goldberg, Terry E; Kane, John M; Robinson, Delbert G; Malhotra, Anil K

    2015-11-01

    First-episode schizophrenia (FES) spectrum disorders are associated with pronounced cognitive dysfunction across all domains. However, less is known about the course of cognitive functioning, following the first presentation of psychosis, and the relationship of cognition to clinical course during initial treatment. The present longitudinal study examined the magnitude of neurocognitive impairment, using the MATRICS Consensus Cognitive Battery, in patients experiencing their first episode of psychosis at baseline and after 12 weeks of randomized antipsychotic treatment with either aripiprazole or risperidone. At baseline, FES patients evidenced marked impairments in cognitive functioning. Notably, performance on the mazes task of planning and reasoning significantly predicted the likelihood of meeting stringent criteria for positive symptom remission during the first 12 weeks of the trial. Performance on indices of general cognitive function, working memory, and verbal learning improved over time, but these improvements were mediated by improvements in both positive and negative symptoms. We did not detect any differential effects of antipsychotic medication assignment (aripiprazole vs risperidone) on cognitive functioning. Our results suggest that a brief paper-and-pencil measure reflecting planning/reasoning abilities may index responsivity to antipsychotic medication. However, improvements in cognitive functioning over time were related to clinical symptom improvement, reflecting "pseudospecificity."

  2. Study on the Relationship between Blood Stasis Syndrome and Clinical Pathology in 227 Patients with Primary Glomerular Disease

    Institute of Scientific and Technical Information of China (English)

    李深; 饶向荣; 王素霞; 张改华; 李晓玫; 戴希文; 陈可冀

    2009-01-01

    To investigate the relationship between the severity of Chinese medicine(CM) bloodstasis syndrome(BSS) with clinical features and renal lesion indexes of the primary glomerular disease. Methods:An epidemiological survey was conducted to collect the data of 227 patients diagnosed as chronic primary glomerular diseases,and their severity of BSS were scored three days before renal biopsies were performed.The following clinical indexes were analyzed:age,course of glomerular diseases,24-h urine protein ration...

  3. The relationship between MR images and clinical findings in neuronal migration disorders

    Energy Technology Data Exchange (ETDEWEB)

    Onuma, Akira; Kobayashi, Yasuko [Takuto Rehabilitation Center for Disabled Children, Sendai (Japan); Iinuma, Kazuie

    1997-07-01

    Among the variable manifestating conditions of neuronal migration disorders, mental retardation, motor disturbance and epilepsy are the main features of developmental disabilities. We analyzed the relationship between clinical symptoms and magnetic resonance (MR) images, including surface anatomy scan (SAS). Thirty-nine patients (23 males, 16 females; mean age 6.1 years) with neuronal migration disorders were studied. The diagnoses were cerebral palsy in 23 cases, mental retardation in 4, West syndrome in 4, Fukuyama type congenital muscular dystrophy (FCMD) in 6, Walker-Warburg syndrome in 1 and Dubowitz syndrome in 1. Cortical dysplasias were classified into the following 7 groups, mainly based on the SAS findings: complete agyria (AG 1), mixture of agyria and pachygyria (AG 2), bilateral complete pachygyria (BP 1), diffuse pachygyria with marked widening of the bilateral superior frontal gyrus (BP 2), unilateral pachygyria with hemispheric atrophy or hemimegalencephaly (UP), focal cortical dysplasia (FP) and other findings such as solitary schizencephaly (Others). Most cases of AG 1 and AG 2 showed spastic quadriplegia (6/7) and symptomatic generalized epilepsy (5/7), whereas cases of BP 1 showed spasticity only in 1/8 and epilepsy in 7/8. Hemiplegia was observed in 6/7 of UP, 2/8 of FP and 2/4 of Others. Partial epilepsy was observed in 2/7 of UP and 1/8 of FP. Intellectual level was variable in BP 1, UP, FP and Others, but all cases showed severe mental retardation in AG 1, AG 2 and BP 2. BP 2 was observed in all cases of typical FCMD (5/5). The birth weight was less than 2,500 g in 6/7 of UP. The structural findings well correlated with clinical symptoms and epileptic seizure types. The surface anatomy scan was a very useful technique for detecting cortical dysplasias. (author)

  4. Non-syndromic congenital hypogonadotropic hypogonadism: clinical presentation and genotype-phenotype relationships.

    Science.gov (United States)

    Brioude, Frédéric; Bouligand, Jérôme; Trabado, Séverine; Francou, Bruno; Salenave, Sylvie; Kamenicky, Peter; Brailly-Tabard, Sylvie; Chanson, Philippe; Guiochon-Mantel, Anne; Young, Jacques

    2010-05-01

    Congenital hypogonadotropic hypogonadism (CHH) results from abnormal gonadotropin secretion, and it is characterized by impaired pubertal development. CHH is caused by defective GNRH release, or by a gonadotrope cell dysfunction in the pituitary. Identification of genetic abnormalities related to CHH has provided major insights into the pathways critical for the development, maturation, and function of the reproductive axis. Mutations in five genes have been found specifically in Kallmann's syndrome, a disorder in which CHH is related to abnormal GNRH neuron ontogenesis and is associated with anosmia or hyposmia. In combined pituitary hormone deficiency or in complex syndromic CHH in which gonadotropin deficiency is either incidental or only one aspect of a more complex endocrine disorder or a non-endocrine disorder, other mutations affecting GNRH and/or gonadotropin secretion have been reported. Often, the CHH phenotype is tightly linked to an isolated deficiency of gonadotropin secretion. These patients, who have no associated signs or hormone deficiencies independent of the deficiency in gonadotropin and sex steroids, have isolated CHH. In some familial cases, they are due to genetic alterations affecting GNRH secretion (mutations in GNRH1, GPR54/KISS1R and TAC3 and TACR3) or the GNRH sensitivity of the gonadotropic cells (GNRHR). A minority of patients with Kallmann's syndrome or a syndromic form of CHH may also appear to have isolated CHH, but close clinical, familial, and genetic studies can reorient the diagnosis, which is important for genetic counseling in the context of assisted reproductive medicine. This review focuses on published cases of isolated CHH, its clinical and endocrine features, genetic causes, and genotype-phenotype relationships.

  5. Ferrokinetic study of splenic erythropoiesis: Relationships among clinical diagnosis, myelofibrosis, splenomegaly, and extramedullary erythropoiesis

    Energy Technology Data Exchange (ETDEWEB)

    Beguin, Y.; Fillet, G.; Bury, J.; Fairon, Y. (Univ. of Liege (Belgium))

    1989-10-01

    Splenic erythropoiesis was demonstrated by surface counting of {sup 59}Fe in 129 of 1,350 ferrokinetic studies performed over a 15 year period. These 129 studies were carried out in 108 patients, including 40 with chronic myelogenous leukemia (CML), 24 with agnogenic myeloid metaplasia (AMM), 18 with polycythemia vera (PV), six with a myelodysplastic syndrome, five with acute leukemia, three with prostate or breast carcinoma, two each with aplastic anemia or Hodgkin's disease, and one each with idiopathic thrombocythemia, multiple myeloma, chronic renal failure, or treated hypopituitarism. Splenomegaly was present in 83% of the studies and hepatomegaly in 72%. Grade II-III myelofibrosis was demonstrated in 62% of the cases. Hepatic erythropoiesis was present in 77% of the studies (only 38% in PV), and marrow erythropoiesis was undetectable in 33%. Total erythropoiesis was about twice normal (range 0.2 to 8 times normal) but was ineffective to varying degrees in 86% of the studies. Relationships between organomegaly, myelofibrosis, and extramedullary erythropoiesis, as well as differences among clinical disorders, are discussed. Differences observed between CML in chronic or blastic phase suggested that the erythroid cell line was involved in the proliferative process. It is concluded that splenic erythropoiesis (1) is encountered in a variety of clinical conditions; (2) is not necessarily associated with splenomegaly or myelofibrosis, even in the myeloproliferative disorders; (3) is part of a predominantly extramedullary (in the liver as well as in the spleen), expanded, and largely inefficient total erythropoiesis; and (4) can be evaluated in a semiquantitative manner by surface counting.

  6. Current perceptions of the term Clinical Pharmacy and its relationship to Pharmaceutical Care: a survey of members of the European Society of Clinical Pharmacy.

    Science.gov (United States)

    Dreischulte, Tobias; Fernandez-Llimos, Fernando

    2016-12-01

    Background The definitions that are being used for the terms 'clinical pharmacy' and 'pharmaceutical care' seem to have a certain overlap. Responsibility for therapy outcomes seems to be especially linked to the latter term. Both terms need clarification before a proper definition of clinical pharmacy can be drafted. Objective To identify current disagreements regarding the term 'Clinical Pharmacy' and its relationship to 'Pharmaceutical Care' and to assess to which extent pharmacists with an interest in Clinical Pharmacy are willing to accept responsibility for drug therapy outcomes. Setting The membership of the European Society of Clinical Pharmacy. Methods A total of 1,285 individuals affiliated with the European Society of Clinical Pharmacy were invited by email to participate in an online survey asking participants to state whether certain professional activities, providers, settings, aims and general descriptors constituted (a) 'Clinical Pharmacy only', (b) 'Pharmaceutical Care only', (c) 'both' or (d) 'neither'. Further questions examined pharmacists' willingness to accept ethical or legal responsibility for drug therapy outcomes, under current and ideal working conditions. Main outcome measures Level of agreement with a number of statements. Results There was disagreement (Pharmaceutical care also encompassed certain professional activities, constituted a scientific discipline and targeted cost effectiveness. The proportions of participants willing to accept legal responsibility under current/ideal working conditions were: safety (32.7%/64.3%), effectiveness (17.9%/49.2%), patient-centeredness (17.1%/46.2%), cost-effectiveness (20.3%/44.0%). Conclusions The survey identified key disagreements around the term 'Clinical Pharmacy' and its relationship to 'Pharmaceutical Care', which future discussions around a harmonised definition of 'Clinical Pharmacy' should aim to resolve. Further research is required to understand barriers and facilitators to pharmacists

  7. Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition

    Science.gov (United States)

    Devous Sr, Michael D.; Navitsky, Michael; Lu, Ming; Salloway, Stephen; Schaerf, Frederick W.; Jennings, Danna; Arora, Anupa K.; McGeehan, Anne; Lim, Nathaniel C.; Xiong, Hui; Joshi, Abhinay D.; Siderowf, Andrew; Mintun, Mark A.

    2017-01-01

    Abstract The advent of tau-targeted positron emission tomography tracers such as flortaucipir (18F-AV-1451, also known as 18F-T807) have made it possible to investigate the sequence of development of tau and amyloid-β in relationship to age, and to the development of cognitive impairment due to Alzheimer’s disease. In this study, flortaucipir tau and florbetapir amyloid positron emission tomography were obtained for 217 subjects including 16 young and 58 older cognitively normal subjects, 95 subjects with mild cognitive impairment (Mini-Mental State Examination 24–30) and 48 subjects with clinically-defined possible or probable Alzheimer’s disease (Mini-Mental State Examination >10). Images were evaluated visually and quantitatively by regional and voxel-based cortical to cerebellar standard uptake value ratios. For amyloid positron emission tomography positive (Aβ+) subjects, flortaucipir neocortical standard uptake value ratio was significantly higher with more advanced clinical stage (Alzheimer’s disease > mild cognitive impairment > older cognitively normal) and was significantly elevated for Aβ+ mild cognitive impairment and Alzheimer’s disease subjects relative to the respective Aβ− subjects. In contrast, florbetapir Aβ− older cognitively normal subjects showed an increase in flortaucipir standard uptake value ratios in mesial temporal lobe regions (amygdala, hippocampus/choroid plexus region of interest) compared to younger cognitively normal subjects, but no increased standard uptake value ratios in neocortical regions. Analysis of covariance with planned contrasts showed no differences in regional or composite posterior neocortical flortaucipir standard uptake value ratio as a function of diagnostic group among Aβ− older cognitively normal or clinically diagnosed Alzheimer’s disease or mild cognitive impairment subjects. The pattern of flortaucipir distribution among Aβ+ subjects was reminiscent of the cross-sectional distribution

  8. Structure-activity relationship studies on clinically relevant HIV-1 NNRTIs.

    Science.gov (United States)

    Rawal, R K; Murugesan, V; Katti, S B

    2012-01-01

    In addition to the nucleoside reverse transcriptase inhibitors (NRTIs), protease inhibitors (PIs) and integrase inhibitors (INIs), nonnucleoside reverse transcriptase inhibitors (NNRTIs) have contributed significantly in the treatment of HIV-1 infections. More than 60 structurally different classes of compounds have been identified as NNRTIs, which are specifically inhibiting HIV-1 reverse transcriptase (RT). Five NNRTIs (nevirapine, delavirdine, efavirenz, etravirine and rilpivirine) have been approved by US Food and Drug Administration (FDA) for clinical use. The NNRTIs bind with a specific 'pocket' site of HIV-1 RT (allosteric site) that is closely associated with the NRTI binding site. Due to mutations of the amino acid residues surrounding the NNRTI-binding site, NNRTIs are notorious for rapidly eliciting resistance. Though, the emergence of resistant HIV strains can be circumvented if the NNRTIs are used either alone or in combination with NRTIs (AZT, 3TC, ddI, ddC, TVD or d4T) and PIs (Indinavir, nelfinavir, saquinavir, ritonavir and lopinavir etc.) as shown by both a decrease in plasma HIV-1 RNA levels and increased CD4 T-cells. Here we are going to discuss recent advances in structure activity relationship studies on nevirapine, delavirdine, efavirenz, etravirine, rilpivirine and 4-thiazolidinones (privileged scaffold) HIV-1 NNRTIs.

  9. Relationship between the Clinical Use of Antibiotic and Production of ESBLS

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Objective:To determine the relationship between the application of antibiotic and the production of extended spectrum β-lactamases (ESBLs).Methods:ESBLs were detected by the double disc diffusion method among 161 gram-negative bacilli isolated from clinical specimens.The use of antibiotic in the patients was investigated before ESBLs were detected. Results:The rate of ESBLs-producing strains was 35.4% (57/161). In the patients with ESBLs-producing strains, the utilization rates of antibiotic and the third-generation cephalosprin were 96.4% (55/57) and 42.1% (24/57) respectively, which were significantly higher than those without ESBLs-producing strains [80.6% (84/104) and 16.3% (17/104), respectively].There were significant differences (P<0.05 and P<0.005,respectively) between the two groups of patients.The duration of the third-generation cephalosprins therapy was significantly longer in the patients with ESBLs-producing strains [(7.5 ± 5.4)d] than those without ESBLs-producing strains [(2.7±2.6)d,P<0.05].Conclusion:The application of antibiotic, especially the third-generation cephalosprins, is the risk factor for the production of ESBLs.

  10. Clinical analysis of the risk factors for recurrence of HCC and its relationship with HBV

    Institute of Scientific and Technical Information of China (English)

    Di-Peng Ou; Lian-Yue Yang; Geng-Wen Huang; Yi-Ming Tao; Xiang Ding; Zhi-Gang Chang

    2005-01-01

    AIM: To comprehend the risk factors of recurrence of hepatocellular carcinoma (HCC) and its relationship with the infection patterns of hepatitis B virus (HBV). METHODS: All materials of 270 cases of postoperative HCC were statistically analyzed by SPSS software. Recurrence and metastasis were classified into early (≤2 years) and late phase (>2 years). Risk factors for recurrence and metastasis after surgery in each group were analyzed.RESULTS: Out of 270 cases of HCC, 162 cases were followed up in which recurrence and metastasis occurred in 136 cases. There were a lot of risk factors related to recurrence and metastasis of HCC; risk factors contributing to early phase recurrence were serum AFP level, vascular invasion, incisal margin and operative transfusion, gross tumor classification and number of intrahepatic node to late phase recurrence. The HBV infective rate of recurrent HCC was 94.1%, in which "HBsAg, HBeAb, HBcAb" positive pattern reached 45.6%. The proportion of HBV infection in solitary large hepatocellular carcinoma (SLHCC) evidently decreased compared to nodular hepatocellular carcinoma (NHCC) (P<0.05).CONCLUSION: The early and late recurrence and metastasis after hepatectomy of HCC were associated with different risk factors. The early recurrence may be mediated by vascular invasion and remnant lesion, the late recurrence by tumor's clinical pathology propert, as multicentric carcinogenesis or intrahepatic carcinoma denovo. HBV replication takes a great role in this process. From this study, we found that SLHCC has more satisfactory neoplasm biological behavior than NHCC.

  11. Relationship between the Expression of α1-Antitrypsinase in Bronchioalveolar Carcinoma and Clinical Pathology

    Institute of Scientific and Technical Information of China (English)

    WU Cuihuan; YANG Yi; HAO Chunrong; NI Juan; CHE Dongyuan; CHEN Chunlian

    2000-01-01

    By using immunohistochemistry LSAB method and imaging analysis technique, the expression of α1-antitrypsinase (α1-AT) in 41 cases of bronchioalveolar carcinoma (BAC) was quantitatively detected to explore the relationship between αl-AT expression in BAC tissues and clinical pathology. The results showed that the total positive rate for αl-AT expression was 85.4%. The positive rate for αl-AT expression in alveolar BAC was 100%, with the immunity reactive staining intensity being significantly higher than in papillary BAC, mucinous BAC or sclerosing BAC (P<0.05). The positive rate in papillary BAC was 93.3%, with the intensity higher mucinous BAC or sclerosing BAC (P<0.01); The positive rate in both mucinous BAC and sclerosing BAC was 66.7% (P>0.05); The expression intensity in lymph node metastatic group was obviously lower than that in the group without metastasis (P<0.01); The patients with mucinous BAC were diagnosed at a younger age than those with other histologic types of BAC (P<0.05). It was suggested that BAC cells could also produce αl-AT. Detection of α1-AT could be used as a new method to diagnose BAC and might play a role in assessing BAC metastasis.

  12. Self esteem and self agency in first episode psychosis: Ethnic variation and relationship with clinical presentation.

    Science.gov (United States)

    Ciufolini, Simone; Morgan, Craig; Morgan, Kevin; Fearon, Paul; Boydell, Jane; Hutchinson, Gerard; Demjaha, Arsjme; Girardi, Paolo; Doody, Gill A; Jones, Peter B; Murray, Robin; Dazzan, Paola

    2015-06-30

    The impact of self esteem and Locus of Control (LoC) on clinical presentation across different ethnic groups of patients at their first psychotic episode (FEP) remains unknown. We explored these constructs in 257 FEP patients (Black n=95; White British n=119) and 341 controls (Black n=70; White British n=226), and examined their relationship with symptom dimensions and pathways to care. FEP patients presented lower self-esteem and a more external LoC than controls. Lower self esteem was associated with a specific symptoms profile (more manic and less negative symptoms), and with factors predictive of poorer outcome (longer duration of untreated psychosis (DUP) and compulsory mode of admission). A more external LoC was associated with more negative symptoms and an insidious onset. When we explored these constructs across different ethnic groups, we found that Black patients had significantly higher self esteem than White British. This was again associated with specific symptom profiles. While British patients with lower self esteem were more likely to report delusions, hallucinations and negative symptoms, Black patients with a lower self esteem showed less disorganization symptoms. These findings suggest that self esteem and LoC may represent one way in which social experiences and contexts differentially influence vulnerable individuals along the pathway to psychosis.

  13. Validation of the Oral Hygiene Habits Scale: Relationships with sociodemographic variables in the general and clinical population of Monterrey, Mexico.

    Directory of Open Access Journals (Sweden)

    Norma Rodríguez

    2016-12-01

    Full Text Available Several socioeconomic factors are associated with poor oral hygiene habits. A version of the Oral Hygiene Habits Scale (OHHS was developed in Mexico to measure these factors; however, its relationship with sociodemographic variables has not been studied. The verification of these relationships could contribute to the validation of the scale. Objective: To evaluate the relationship between oral hygiene habits and sociodemographic variables of sex, age, schooling, self-defined socioeconomic stratum, occupation and marital status in the general and clinical population of Monterrey, Mexico. Materials and Methods: A general population sample (GPS of 256 participants and a clinical sample (CPS of 240 participants were studied. The OHHS consisted of an eight-item Likert scale of 4 points ranging from 0 to 4. A descriptive correlational study was performed with a cross-sectional design. Data were analyzed using the Mann-Whitney U test, Kruskal-Wallis test, Spearman correlation coefficient, Cramer's V coefficient, and multivariate aligned rank test. Results: In GPS and CPS groups, OHHS was related to sex, schooling, socioeconomic stratum, occupation and marital status, but not to age. There were no significant interactions between the samples (GPS and CPS and sociodemographic variables. Conclusion: There is a statistically significant relationship between oral hygiene habits and some sociodemographic variables in the general and clinical population. This relationship supports the validity of the OHHS.

  14. The Relationship between Method of Clinical Instruction in Radiography and Scores on the American Registry of Radiologic Technologists Certification Examination.

    Science.gov (United States)

    Dowd, Steven B.

    An examination was made of the relationship between clinical grade based on simulation and a subsequent outcome measurement, the national certification examination in radiography. Although the new "Essentials" developed by the Joint Review Committee in Education in Radiologic Technology discouraged use of simulation, the method had…

  15. Patients with chronic whiplash-associated disorders. Relationship between clinical and psychological factors and functional health status

    NARCIS (Netherlands)

    Schmitt, M.A.; Meeteren, N.L. van; Wijer, A. de; Genderen, F.R. van; Graaf, Y.D. van; Helders, P.J.

    2009-01-01

    Schmitt MA, van Meeteren NL, de Wijer A, van Genderen FR, van der Graaf Y, Helders PJ: Patients with chronic whiplash-associated disorders: Relationship between clinical and psychological factors and functional health status. Am J Phys Med Rehabil 2009;88:231-238. Objectives: To examine the relative

  16. Relationship between psychiatric status, self-reported outcome measures, and clinical parameters in axial spondyloarthritis.

    Science.gov (United States)

    Kilic, Gamze; Kilic, Erkan; Ozgocmen, Salih

    2014-12-01

    This article aims to compare the risks of depression and anxiety in patients with ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (nr-axSpA) and investigate the relationship among self-reported outcome measures, clinical parameters, and physical variables of patients with axSpA. Patients with axSpA were recruited from Erciyes Spondyloarthritis Cohort. The patients met Assessment of Spondyloarthritis International Society classification criteria for axial SpA and were assessed in a cross-sectional study design for visual analog scale (VAS) pain, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Ankylosing Spondylitis Quality of Life questionnaire (ASQoL), and Ankylosing Spondylitis Disease Activity Score-C-reactive protein (ASDAS-CRP). Psychological status was evaluated using the hospital anxiety and depression scale (HADS). Multivariate logistic regression analysis was applied to determine the associations between psychological variables and clinical parameters after adjusting for confounding variables. Of the 316 patients (142 nr-axSpA, 174 AS), 139 (44%) had high risk for depression (HADS-D score ≥ 7) and 71 (22.5%) for anxiety (HADS-A score ≥ 10). HADS-D and HADS-A scores were similar between patients with AS and nr-axSpA. Patients with high risk for depression and anxiety had higher scores in BASDAI, BASFI, and ASDAS-CRP, and also poorer scores in VAS pain and ASQoL. Multivariate logistic regression analysis showed that the ASDAS-CRP, ASQoL, BASDAI, as well as educational level were factors associated with the risk of depression whereas the ASQoL and educational level were factors associated with the risk of anxiety. Patients with nr-axSpA and AS have similar burden of psychological distress. The quality of life (ASQoL) and educational level were factors associated with the risk of both depression and anxiety whereas disease activity (BASDAI and ASDAS-CRP) was the

  17. Factor V leiden mutation in Behcet’s disease and the relationship with clinical manifestations

    Directory of Open Access Journals (Sweden)

    Mowla K

    2010-05-01

    Full Text Available "n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Behcet's disease (BD is a multisystemic inflammatory disease with unknown origin characterized by recurrent oral aphtous ulcers, genital, ocular and skin lesions. A single point mutation 1691G to A in the factor V gene increases the risk of venous thrombosis. This study designed to determine factor V Leiden mutation in Behcet's disease, and to find out it's relationship with the clinical manifestations in Khuzestan province, Iran. "n"nMethods: One hundred patients with Behcet's Disease (44 males and 56 females based on international diagnostic criteria and 70 healthy subjects were included in the study. Patients and controls were tested for the presence of factor V Leiden mutation using polymerase chain reaction method."n"nResults: The prevalence of factor V Leiden mutation was significantly higher in BD (10 out of 100, 10% compared with healthy control subjects (1 out of 70, 1.4%, (p=0.025. Vascular lesions in this study were deep vein thrombosis (DVT (7%, subcutaneous thrombophlebitis (5%, stroke (1% and retinal vasculitis (39%. It was found that there was no association between venous thrombosis and the factor V Leiden mutation in Khuzestanian patients. Also, no association between

  18. Comparative Genomic Analysis of Clinical and Environmental Vibrio Vulnificus Isolates Revealed Biotype 3 Evolutionary Relationships

    Directory of Open Access Journals (Sweden)

    Yael eKotton

    2015-01-01

    Full Text Available In 1996 a common-source outbreak of severe soft tissue and bloodstream infections erupted among Israeli fish farmers and fish consumers due to changes in fish marketing policies. The causative pathogen was a new strain of Vibrio vulnificus, named biotype 3, which displayed a unique biochemical and genotypic profile. Initial observations suggested that the pathogen erupted as a result of genetic recombination between two distinct populations. We applied a whole genome shotgun sequencing approach using several V. vulnificus strains from Israel in order to study the pan genome of V. vulnificus and determine the phylogenetic relationship of biotype 3 with existing populations. The core genome of V. vulnificus based on 16 draft and complete genomes consisted of 3068 genes, representing between 59% and 78% of the whole genome of 16 strains. The accessory genome varied in size from 781 kbp to 2044 kbp. Phylogenetic analysis based on whole, core, and accessory genomes displayed similar clustering patterns with two main clusters, clinical (C and environmental (E, all biotype 3 strains formed a distinct group within the E cluster. Annotation of accessory genomic regions found in biotype 3 strains and absent from the core genome yielded 1732 genes, of which the vast majority encoded hypothetical proteins, phage-related proteins, and mobile element proteins. A total of 1916 proteins (including 713 hypothetical proteins were present in all human pathogenic strains (both biotype 3 and non-biotype 3 and absent from the environmental strains. Clustering analysis of the non-hypothetical proteins revealed 148 protein clusters shared by all human pathogenic strains; these included transcriptional regulators, arylsulfatases, methyl-accepting chemotaxis proteins, acetyltransferases, GGDEF family proteins, transposases, type IV secretory system (T4SS proteins, and integrases. Our study showed that V. vulnificus biotype 3 evolved from environmental populations and

  19. Nutrition-Related Cardiovascular Disease Risk Factors In Chronic Kidney Disease: Relationship With Clinical Outcome

    Directory of Open Access Journals (Sweden)

    Emma McMahon

    2012-06-01

    Traditional CV-risk factors in this CKD population were not associated with clinical outcome. Despite being within clinical reference range, serum phosphate and albumin were independently associated with clinical outcome. This may highlight a potential therapeutic target for risk management to delay or prevent renal end-points in CKD.

  20. Illness, body and relationship: Giovanni Jervis and the field of clinical psychology.

    Science.gov (United States)

    Williams, Riccardo

    2012-01-01

    Unlike most of his contemporaries, Jervis felt it was necessary to give new answers to last century's clinical psychology crisis. He managed to show the relevance that psychological knowledge coming from other sectors (such as philosophy, evolutionary biology, cybernetics, ethology and, nowadays, neuroscience) could have for clinical psychology. He realized that the clinical world was at risk of loosing its cultural models of reference and threatened to break up with the scientific tradition with which it had not been able to establish a profitable dialogue. Jervis' views on mental functioning allowed him to delimit the field of action of clinical psychology. The focus on pathology and existential distress suggested that correct clinical evaluation and diagnosis are at the core of the activity of clinical psychologists. The tension between relational expectations, self-deceptive aspects of identity and the bodily sources of mental life show the dynamic field on which clinical psychology can deploy its transformative action.

  1. Relationship-Specific Condom Attitudes Predict Condom Use among STD Clinic Patients with both Primary and Non-Primary Partners

    Science.gov (United States)

    Senn, Theresa E.; Scott-Sheldon, Lori A. J.; Carey, Michael P.

    2014-01-01

    Although condom use differs by partner type (i.e., primary vs. non-primary partner), attitudes towards condom use are typically measured without consideration of partner type. This study investigated the predictive utility of condom attitudes measured separately by partner type. Participants were 270 patients (37% women, 72% Black) recruited from a publicly-funded STD clinic who reported having both primary and non-primary partners. They completed a computerized survey assessing relationship-specific condom attitudes by partner type, condom attitudes related to pleasure and respect, and condom use with primary and non-primary partners. Participants reported more positive relationship-specific condom attitudes with a non-primary vs. primary partner. When considering pleasure-related, respect-related, and relationship-specific condom attitudes simultaneously, only relationship-specific condom attitudes predicted unprotected sex, with both primary and non-primary partners. In general, pleasure and respect-related condom attitudes did not predict unprotected sex; however, pleasure-related attitudes predicted unprotected sex with a non-primary partner for men. Future research should assess relationship-specific condom attitudes. Sexual risk reduction interventions that address interpersonal consequences of condom use in both primary and non-primary relationships should be a priority. PMID:24567031

  2. Relationship between somatic cell count status and subsequent clinical mastitis in Dutch dairy cows.

    Science.gov (United States)

    van den Borne, B H P; Vernooij, J C M; Lupindu, A M; van Schaik, G; Frankena, K; Lam, T J G M; Nielen, M

    2011-12-15

    High composite somatic cell counts (CSCC) in dairy cows may develop into clinical mastitis (CM), suggesting that prevention or intervention of high CSCC may prevent CM later in lactation. The objective of this study was to quantify the relationship between high CSCC in dairy cows and the first subsequent case of CM in the same lactation. Farmer-diagnosed cases of CM and test day CSCC measurements during 1 year of 13,917 cows in 196 randomly selected Dutch dairy herds were available for analysis. Cows were followed in 1 lactation from the first test day postpartum until CM, drying off, culling or end of study. Cox proportional hazards models with time-varying CSCC levels were used to estimate the effect of high CSCC (≥200,000cells/ml) on the time until the first case of CM. A shared frailty effect was included to adjust for clustering of cows within herds. The proportion of cows developing CM after a CSCC measurement was 11%. Primiparae with a high CSCC had a 4-fold higher hazard for subsequent CM than primiparae with a low CSCC; multiparae with a high CSCC had a 2-fold higher hazard than multiparae with a low CSCC. Additionally, multiparae with a low CSCC had a 2-fold higher hazard for CM occurrence than primiparae with a low CSCC. Increasing the threshold for high CSCC showed that the risk for CM increased. If the last CSCC before CM was low, CSCC information of 2 preceding test days was more predictive than CSCC information from only the last test day. When the last CSCC was high, CSCC information of 2 preceding test days did not have added predictive value. This study identified that approximately 25% of first subsequent CM cases after a CSCC measurement can potentially be prevented when cows are prevented to get high CSCC or when high CSCC cows are removed from the population. This corresponded with a decrease in the proportion of lactating cows with CM after a CSCC measurement from 11% to 7%.

  3. [Relationship between the courses of clinical Features of patients with schizophrenia in adolescents and admission to psychiatric clinic].

    Science.gov (United States)

    Hattori, Isao; Miyauchi, Toshiro

    2005-01-01

    In order to improve diagnosis of schizophrenia with onset in adolescents at an early stage, we investigated in detail the clinical features of 74 patients with schizophrenia, (23 males) at adolescents psychiatric clinic. Many of the subjects had been suffering from the illness about 14 years old but had not undergone their first psychiatric examination until a few years later. A high percentage (more than 80%) of our subjects presented psychiatric symptoms such as delusional remembrance, delusional moods, delusions of persecution and hypobulia. Additionally, more than 60% of our subjects presented auditory hallucinations. In general, teenage patients with schizophrenia onset show vague symptoms such as anxiety, embarrassment and strange moods rather than obvious hallucinations. Nevertheless, it was possible to identify certain clinical features of this disorder in adolescents: many patients suffer delusional remembrance, delusional moods and delusions of persecution immediately after the onset of the illness. Gradually, problematic behaviors such as anorexia, self injury, offences against their families, voluntary vomiting, etc., develop, but patients do not always receive psychiatric examination at this stage. After socially obvious problems such as school refusal, withdrawal from social activities and lowering of school record develop over a period of time, patients may be urged to undergo psychiatric examination. Our research again underlines the difficulty of achieving diagnosis of schizophrenia at an early stage. The key to early diagnosis appears to be the accurate identification of psychiatric symptoms in the early stages of the illness at school, or at home if possible, before socially problematic behaviors arise.

  4. Population Relationship of Vibrio parahaemolyticus Isolates Derived from Aquaculture Ponds, a Seafood Market, Restaurants, and Clinical Samples.

    Science.gov (United States)

    Gao, Lei; Deng, Yi Qin; Chen, Chang; Ke, Chang Wen; Li, Bo Sheng; Long, Yun Ying; Liu, Zhu Hong; Wei, Lu

    2016-06-01

    To study the relationship between environmental and clinical populations of Vibrio parahaemolyticus, we collected in total 86 isolates from Southern China during one and a half years. Sixty-eight isolates were recovered from aquaculture ponds, a seafood market, and restaurants, and 18 isolates were recovered from clinical samples. Virulence gene analysis revealed that 25 isolates (14 clinical and 11 environmental) tested positive for tdh, but only 4 carried trh. Interestingly, none of the tdh(+) environmental isolates was recovered from ponds. Both environmental and clinical tdh(+) isolates, except for one clinical isolate, harbor type III secretion system 2α (T3SS2α) and T3SS2β-related genes, including vopB2α, which was previously suggested to be absent from environmental strains. More than 70% of clinical isolates carried the pandemic marker of new toxRS (GS-PCR(+)), which was not present in the environmental isolates. Pulsed-field gel electrophoresis and multilocus sequence typing analysis showed a high degree of genetic diversity within the environmental isolates. In contrast, the clinical population formed a tight cluster that differed from the environmental isolates. These findings suggest that the pandemic strains of V. parahaemolyticus may not directly originate from marine animals. Rather the environments where they are maintained could serve as reservoirs for toxigenic, but not pandemic strains. These environments provide an ideal place for generation of new toxigenic strains through DNA exchange, which was revealed by extensive recombination events in recA sequences of the environmental isolates.

  5. CPTAC Establishes Formal Relationships with Two Academic Institutions in Taiwan - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium (CPTAC) has entered into memorandum of understandings (MOUs) with Chang Gung University and Academia Sinica, in Taipei, Taiwan.

  6. Doctor and patient’s relationship at the present time and value of the clinical method

    Directory of Open Access Journals (Sweden)

    Orlando Cruz Martínez

    2010-12-01

    Full Text Available The history of mankind is not only made of the relationships and conflicts among men: the struggle to survive is also part of it and the hardest and most persistent of all has been men’s fight against diseases. The emergence of medical activity is inextricably linked to the development of human relationships. In fact, it is precisely the capacity of establishing relationships with others what identifies and distinguishes man from other biological beings. The recognition of the values of the doctor-patient relationship and its psychological moment is gnoseologically attached to the recognition of the values of the integral vision of man. That is why the Hippocratic school, constantly insisting that man is not only the physical aspect, but an inseparable whole with the psychic aspect and emphasizing on the importance of the environment and the doctor-patient relationship constitutes a milestone in the development of medicine. Over the centuries much has been learned and even more has been written about this unique kind of human relationship that causes everyday a renewed interest not only for medicine but also for many adjacent disciplines, as a sign of its decisive importance and the socio-historical conditions that determine it.

  7. A method to adjust radiation dose-response relationships for clinical risk factors

    DEFF Research Database (Denmark)

    Appelt, Ane Lindegaard; Vogelius, Ivan R

    2012-01-01

    Several clinical risk factors for radiation induced toxicity have been identified in the literature. Here, we present a method to quantify the effect of clinical risk factors on radiation dose-response curves and apply the method to adjust the dose-response for radiation pneumonitis for patients...

  8. Critical Thinking and Clinical Competence: A Study of Their Relationship in BSN Seniors.

    Science.gov (United States)

    May, Barbara A.; Edell, Vivian; Butell, Sue; Doughty, Jana; Langford, Cheryl

    1999-01-01

    Graduating nursing students (n=143) completed a critical-thinking skills test and disposition inventory and clinical competence evaluation. No significant correlation between critical thinking and clinical competence appeared. Critical thinking is possibly not associated with competence until after acquiring work experience. (SK)

  9. Relationship of neuroimaging to typical sleep times during a clinical reasoning task: a pilot study

    NARCIS (Netherlands)

    Durning, S.J.; Kelly, W.; Costanzo, M.E.; Artino, A.R.; Vleuten, C.P.M. van der; Beckman, T.J.; Roy, M.J.H.M. van; Holmboe, E.S.; Wittich, C.M.; Schuwirth, L.

    2015-01-01

    BACKGROUND: Sleep deprivation and fatigue have been associated with medical errors, clinical performance decrements, and reduced quality of life for both practicing physicians and medical students. Greater understanding of the impact of sleep quantity on clinical reasoning could improve patient care

  10. The relationship between clinical outcomes and medication adherence in difficult-to-control asthma.

    Science.gov (United States)

    Murphy, Anna C; Proeschal, Amandine; Brightling, Christopher E; Wardlaw, Andrew J; Pavord, Ian; Bradding, Peter; Green, Ruth H

    2012-08-01

    Medication non-adherence and the clinical implications in difficult-to-control asthma were audited. Prescription issue data from 115 patients identified sub-optimal adherence (asthma (p=0.008). The majority of patients with difficult-to-control asthma are non-adherent with their asthma medication. Non-adherence is correlated with poor clinical outcomes.

  11. The relationship between visual orienting responses and clinical characteristics in children attending special education for the visually impaired.

    Science.gov (United States)

    Kooiker, Marlou J G; Pel, Johan J M; van der Steen, Johannes

    2015-05-01

    We recently introduced a method based on quantification of orienting responses toward visual stimuli to assess the quality of visual information processing in children. In the present study, we examined the relationship between orienting responses and factors that are associated with visual processing impairments in current clinical practice. Response time and fixation quality to visual features such as form, contrast, motion, and color stimuli were assessed in 104 children from 1 to 12 years attending special education for the visually impaired. Using regression analysis, we investigated whether these parameters were affected by clinical characteristics of children. Response times significantly depended on stimulus type. Responses to high-contrast cartoons were significantly slower in children with a clinical diagnosis of cerebral visual impairment. Fixation quality was significantly affected by visual acuity and nystagmus. The results suggest that the quantitative measurement of orienting responses is strongly related to cerebral visual impairment in children.

  12. The doctor-patient relationship as a toolkit for uncertain clinical decisions.

    Science.gov (United States)

    Diamond-Brown, Lauren

    2016-06-01

    Medical uncertainty is a well-recognized problem in healthcare, yet how doctors make decisions in the face of uncertainty remains to be understood. This article draws on interdisciplinary literature on uncertainty and physician decision-making to examine a specific physician response to uncertainty: using the doctor-patient relationship as a toolkit. Additionally, I ask what happens to this process when the doctor-patient relationship becomes fragmented. I answer these questions by examining obstetrician-gynecologists' narratives regarding how they make decisions when faced with uncertainty in childbirth. Between 2013 and 2014, I performed 21 semi-structured interviews with obstetricians in the United States. Obstetricians were selected to maximize variation in relevant physician, hospital, and practice characteristics. I began with grounded theory and moved to analytical coding of themes in relation to relevant literature. My analysis renders it evident that some physicians use the doctor-patient relationship as a toolkit for dealing with uncertainty. I analyze how this process varies for physicians in different models of care by comparing doctors' experiences in models with continuous versus fragmented doctor-patient relationships. My key findings are that obstetricians in both models appealed to the ideal of patient-centered decision-making to cope with uncertain decisions, but in practice physicians in fragmented care faced a number of challenges to using the doctor-patient relationship as a toolkit for decision-making. These challenges led to additional uncertainties and in some cases to poor outcomes for doctors and/or patients; they also raised concerns about the reproduction of inequality. Thus organization of care delivery mitigates the efficacy of doctors' use of the doctor-patient relationship toolkit for uncertain decisions. These findings have implications for theorizing about decision-making under conditions of medical uncertainty, for understanding

  13. Genetic relationships between clinical and non-clinical strains of Yersinia enterocolitica biovar 1A as revealed by multilocus enzyme electrophoresis and multilocus restriction typing

    Directory of Open Access Journals (Sweden)

    Virdi Jugsharan S

    2010-05-01

    Full Text Available Abstract Background Genetic relationships among 81 strains of Y. enterocolitica biovar 1A isolated from clinical and non-clinical sources were discerned by multilocus enzyme electrophoresis (MLEE and multilocus restriction typing (MLRT using six loci each. Such studies may reveal associations between the genotypes of the strains and their sources of isolation. Results All loci were polymorphic and generated 62 electrophoretic types (ETs and 12 restriction types (RTs. The mean genetic diversity (H of the strains by MLEE and MLRT was 0.566 and 0.441 respectively. MLEE (DI = 0.98 was more discriminatory and clustered Y. enterocolitica biovar 1A strains into four groups, while MLRT (DI = 0.77 identified two distinct groups. BURST (Based Upon Related Sequence Types analysis of the MLRT data suggested aquatic serotype O:6,30-6,31 isolates to be the ancestral strains from which, clinical O:6,30-6,31 strains might have originated by host adaptation and genetic change. Conclusion MLEE revealed greater genetic diversity among strains of Y. enterocolitica biovar 1A and clustered strains in four groups, while MLRT grouped the strains into two groups. BURST analysis of MLRT data nevertheless provided newer insights into the probable evolution of clinical strains from aquatic strains.

  14. Biofilm formation in clinical isolates of nosocomial Acinetobacter baumannii and its relationship with multidrug resistance

    Directory of Open Access Journals (Sweden)

    Ebrahim Babapour

    2016-06-01

    Conclusions: Since most of the multidrug resistant strains produce biofilm, it seems necessary to provide continuous monitoring and determination of antibiotic susceptibility of clinical A. baumannii. This would help to select the most appropriate antibiotic for treatment.

  15. Distinct features of circulating microparticles and their relationship to clinical manifestations in systemic lupus erythematosus

    DEFF Research Database (Denmark)

    Nielsen, Christoffer T; Østergaard, Ole; Johnsen, Christina

    2011-01-01

    Characterization of the abundance, origin, and annexin V (AnxV)-binding capabilities of circulating microparticles (MPs) in SLE patients and healthy controls and to determine any associations with clinical parameters....

  16. The Relationship between Clinical and Chemical Hyperandrogenism in 14-18-Years- Old Girls

    OpenAIRE

    Tahereh Naderi; Marzieh Akbarzadeh; Mohammad Hossain Dabbaghmanesh; Hamidreza Tabatabaee; Zahra Zareh

    2012-01-01

    Background: One of the most common endocrine disorders in women's medicine is the increased androgen and the symptoms of increased androgens in women such as polycystic ovary syndrome. The two main components to diagnose this syndrome are menstrual disorder and clinical or laboratory hyperandrogenism, but other causes should be ruled out in order to confirm the diagnosis. This study aims to examine clinical Hyperandrogenism in female students of 14 to 18 years old in Shiraz in 2010.Materials ...

  17. Relationship between obesity and the risk of clinically significant depression: Mendelian randomisation study.

    LENUS (Irish Health Repository)

    Hung, Chi-Fa

    2014-07-01

    Obesity has been shown to be associated with depression and it has been suggested that higher body mass index (BMI) increases the risk of depression and other common mental disorders. However, the causal relationship remains unclear and Mendelian randomisation, a form of instrumental variable analysis, has recently been employed to attempt to resolve this issue.

  18. The Relationship of Asperger's Characteristics and Schizotypal Personality Traits in a Non-Clinical Adult Sample

    Science.gov (United States)

    Hurst, Ruth M.; Nelson-Gray, Rosemery O.; Mitchell, John T.; Kwapil, Thomas R.

    2007-01-01

    The study examines the relationship between Asperger's Disorder (AD) and Schizotypal Personality Disorder (SPD), mutually exclusive but similar diagnoses ["DSM-IV-TR;" American Psychiatric Association (2000). "Diagnostic and statistical manual of mental disorders." Washington, DC: Author]. The literature and comparison of diagnostic criteria…

  19. Relationship between clinical features of facial dry skin and biophysical parameters in Asians.

    Science.gov (United States)

    Baek, J H; Lee, M Y; Koh, J S

    2011-06-01

    There have been few reports classifying the biophysical characteristics of Korean women with healthy skin. Consequently, the aim of this study was to find the most useful parameters for categorizing skin types based on a clinical assessment. One hundred and three female volunteers, aged 20-59, participated in this study. We conducted a self-evaluation questionnaire, a clinical assessment of the facial skin, and non-invasive measurements on the cheek under controlled environmental conditions. The questionnaire survey indicated that 72% of respondents had dry skin. However, results of the clinical assessment focusing on skin roughness and scaling of the cheek showed that 6 subjects had very dry skin (6%), 29 had dry skin (28%) and 68 had normal skin with sufficient moisture (66%). We analysed the correlation between the clinical assessment and biophysical parameters. As a result, we obtained six biophysical parameters that had relatively higher correlations with clinical assessment than other parameters. Our study provided general information about the physiological characteristics of normal skin in Korean women and suggested useful parameters for characterizing dry skin.

  20. Biofilm formation in clinical isolates of nosocomial Acinetobacter baumannii and its relationship with multidrug resistance

    Institute of Scientific and Technical Information of China (English)

    Ebrahim Babapour; Azam Haddadi; Reza Mirnejad; Seyed-Abdolhamid Angaji; Nour Amirmozafari

    2016-01-01

    Objective: To check biofilm formation by Acinetobacter baumannii(A. baumannii)clinical isolates and show their susceptibility to different antibiotics and investigate a possible link between establishment of biofilm and multidrug resistance.Methods: This study was performed on clinical samples collected from patients with nosocomial infections in three hospitals of Tehran. Samples were initially screened by culture and biochemical tests for the presence of different species of Acinetobacter. Identifications were further confirmed by PCR assays. Their susceptibilities to 11 antibiotics of different classes were determined by disc diffusion method according to Clinical and Laboratory Standards Institute guidelines. The ability to produce biofilm was investigated using methods: culture on Congo red agar, microtiter plate, and test tube method.Results: From the overall clinical samples, 156 specimens were confirmed to contain A. baumannii. The bacteria were highly resistant to most antibiotics except polymyxin B.Of these isolates, 10.26% were able to produce biofilms as shown on Congo red agar.However, the percentage of bacteria with positive biofilm in test tube, standard microtiter plate, and modified microtiter plate assays were 48.72%, 66.66%, and 73.72%, respectively. At least 92% of the biofilm forming isolates were multidrug resistant.Conclusions: Since most of the multidrug resistant strains produce biofilm, it seems necessary to provide continuous monitoring and determination of antibiotic susceptibility of clinical A. baumannii. This would help to select the most appropriate antibiotic for treatment.

  1. Biofilm formation in clinical isolates of nosocomial Acinetobacter baumannii and its relationship with multidrug resistance

    Institute of Scientific and Technical Information of China (English)

    Ebrahim Babapour; Azam Haddadi; Reza Mirnejad; Seyed-Abdolhamid Angaji; Nour Amirmozafari

    2016-01-01

    Objective: To check biofilm formation by Acinetobacter baumannii (A. baumannii) clinical isolates and show their susceptibility to different antibiotics and investigate a possible link between establishment of biofilm and multidrug resistance. Methods: This study was performed on clinical samples collected from patients with nosocomial infections in three hospitals of Tehran. Samples were initially screened by culture and biochemical tests for the presence of different species of Acinetobacter. Iden-tifications were further confirmed by PCR assays. Their susceptibilities to 11 antibiotics of different classes were determined by disc diffusion method according to Clinical and Laboratory Standards Institute guidelines. The ability to produce biofilm was investigated using methods:culture on Congo red agar, microtiter plate, and test tube method. Results: From the overall clinical samples, 156 specimens were confirmed to contain A. baumannii. The bacteria were highly resistant to most antibiotics except polymyxin B. Of these isolates, 10.26% were able to produce biofilms as shown on Congo red agar. However, the percentage of bacteria with positive biofilm in test tube, standard microtiter plate, and modified microtiter plate assays were 48.72%, 66.66%, and 73.72%, respec-tively. At least 92%of the biofilm forming isolates were multidrug resistant. Conclusions: Since most of the multidrug resistant strains produce biofilm, it seems necessary to provide continuous monitoring and determination of antibiotic susceptibility of clinical A. baumannii. This would help to select the most appropriate antibiotic for treatment.

  2. Poststroke Shoulder Pain in Turkish Stroke Patients: Relationship with Clinical Factors and Functional Outcomes

    Science.gov (United States)

    Barlak, Aysegul; Unsal, Sibel; Kaya, Kurtulus; Sahin-Onat, Sule; Ozel, Sumru

    2009-01-01

    The objective of this study was to assess the possible causes of hemiplegic shoulder pain (HSP) in Turkish patients with stroke, to identify the correlation between HSP and clinical factors, and to review the effects of HSP on functional outcomes. A total of 187 consecutive patients with stroke were evaluated for the presence of HSP and for the…

  3. The Relationship between Athletic Training Student Critical Thinking Skills and Clinical Instructor Supervision: A Pilot Study

    Science.gov (United States)

    Kabay, Michele R.

    2013-01-01

    The purpose of this study was to 1) assess the critical thinking skill level of the athletic training student at onset and end of the clinical education experience 2) to examine the influence of the students' critical thinking skills and the CIs' supervision responses to the changes in the students' critical thinking skills and 3) to compare the…

  4. The Relationship between Emotional Intelligence, Self-Efficacy, and Clinical Performance in Associate Degree Nursing Students

    Science.gov (United States)

    Rice, Eileen W.

    2013-01-01

    The purpose of this study was to explore self-efficacy, an individual's beliefs about his or her ability to perform a series of tasks, and emotional intelligence, an individual's ability to perceive, use, understand, and manage emotions, as predictors for successful clinical performance in nursing students. The participants were 49 female and 7…

  5. Insight change in psychosis : relationship with neurocognition, social cognition, clinical symptoms and phase of illness

    NARCIS (Netherlands)

    Quee, P. J.; van der Meer, L.; Krabbendam, L.; de Haan, L.; Cahn, W.; Wiersma, D.; van Beveren, N.; Pijnenborg, G. H. M.; Mulder, C. L.; Bruggeman, R.; Aleman, A.

    2014-01-01

    Objective: Impaired insight is an important and prevalent symptom of psychosis. It remains unclear whether cognitive disturbances hamper improvements in insight. We investigated the neurocognitive, social cognitive, and clinical correlates of changes in insight. Method: One hundred and fifty-four pa

  6. The relationship between the quality of education and the poor dental practice: Clinical case report

    Directory of Open Access Journals (Sweden)

    Cléa Adas Saliba Garbin

    2013-01-01

    Full Text Available The activities developed in health area are of great importance, because they have the aim to preserve the life of the men, and therefore, must be performed by authorized persons. The increase of the number of dental schools, the decline at the education quality and a higher admission of students with low ability to exercise their profession, are facts that bring disastrous consequences for society. These facts are, also, reflected at the moral, ethical and technical-scientific performance of the professional. The purpose of this clinic case is to show that although there is a significant suplly of education institutions, there is a lack of scientific and adequate technical knowledgement from the graduated dentals surgeons. The patient MSL, 17 year old, female, went to a dental clinic presenting a tray type Vernis, attached to the lower arch. After clinical evaluation, it was showed that an incorrect material was used for the impression technique, being impossible to take out the tray by the conventional mann r. The planning for the removal of the tray was through the divide of it. Thus, the consequence of the lack of knowledge in the use of impression materials had caused a great incovinience to the patient. It can be concluded that the rate of malpractice is directly related to the professional preparation, highlighting the importance of quality dental education for a responsible clinical practice.

  7. Tocilizumab and multiple sclerosis: a causal relationship? Clinical Commentary on the case report entitled--MS arising during Tocilizumab therapy for rheumatoid arthritis.

    Science.gov (United States)

    Comabella, Manuel

    2016-02-01

    This clinical commentary discusses on the potential relationship between multiple sclerosis (MS) and tocilizumab in a patient with rheumatoid arthritis who developed MS while on treatment with this anti-interleukin-6 agent.

  8. The relationship of interictal epileptiform discharges to clinical epilepsy severity: a study of routine electroencephalograms and review of the literature.

    Science.gov (United States)

    Selvitelli, Megan F; Walker, Linsey M; Schomer, Donald L; Chang, Bernard S

    2010-04-01

    Electroencephalograms are widely used to detect interictal epileptiform discharges (IEDs) in patients with a known history of seizures. However, previous studies have not found a consistent association between the presence or frequency of IEDs and clinical epilepsy severity, possibly because of differences in subject characteristics and recording techniques. We sought to investigate this relationship in a population and setting reflective of the most common clinical usage. We analyzed electroencephalograms and clinical records of all consenting patients with a history of at least two presumed focal-onset seizures who presented for routine electroencephalograms recording over 1-year time in an academic neurophysiology laboratory (n = 129). Despite adequate statistical power, we did not find an association between the presence or absence of IEDs or IED frequency and the most recently determined seizure frequency (median, 4 per year). A higher IED incidence was seen in subjects with longer epilepsy duration (P = 0.04). Neither IED incidence nor frequency (median, 10.0 per hour) correlated with age or antiepileptic drug use. Our results differ from those of some previous studies, most of which focused on more narrow subject populations, suggesting that the patient's clinical circumstances must be taken into account before assuming the utility of IEDs on routine electroencephalography in predicting epilepsy severity.

  9. Telomere length in non-neoplastic colonic mucosa in ulcerative colitis (UC) and its relationship to the severe clinical phenotypes.

    Science.gov (United States)

    Tahara, Tomomitsu; Shibata, Tomoyuki; Okubo, Masaaki; Kawamura, Tomohiko; Sumi, Kazuya; Ishizuka, Takamitsu; Nakamura, Masakatsu; Nagasaka, Mitsuo; Nakagawa, Yoshihito; Ohmiya, Naoki; Arisawa, Tomiyasu; Hirata, Ichiro

    2015-08-01

    Telomere shortening occurs with human aging in many organs and tissues and is accelerated by rapid cell turnover and oxidative injury. To clarify the clinical importance of telomere shortening in colonic mucosa in ulcerative colitis (UC), we measured average telomere length using quantitative real-time PCR in non-neoplastic colonic mucosa in UC patients and assessed its relationship to various clinical subtypes. Relative telomere length in genomic DNA was measured in colonic biopsies obtained from rectal inflammatory mucosa from 86 UC patients as well as paired non-inflammatory proximal colonic mucosae from 10 patients. Data were correlated with various clinical phenotypes. In paired samples, average relative telomere length of rectal inflammatory mucosa was shortened compared to normal appearing proximal colon in eight out of ten cases (p = 0.01). Telomere length shortening was significantly associated with more severe Mayo endoscopic subscore (p telomere length was significantly shortened in the same phenotypes than the others (p = 0.003). Telomere shortening is associated with more severe clinical phenotypes of UC, reflecting severe inflammatory state in the colonic mucosa.

  10. Potential Relationship between Season of Birth and Clinical Characteristics in Major Depressive Disorder in Koreans: Results from the CRESCEND Study.

    Science.gov (United States)

    Park, Seon-Cheol; Sakong, Jeong-Kyu; Koo, Bon Hoon; Kim, Jae-Min; Jun, Tae-Youn; Lee, Min-Soo; Kim, Jung-Bum; Yim, Hyeon-Woo; Park, Yong Chon

    2016-05-01

    We aimed to examine the potential relationship between season of birth (SOB) and clinical characteristics in Korean patients with unipolar non-psychotic major depressive disorder (MDD). Using data from the Clinical Research Center for Depression (CRESCEND) study in South Korea, 891 MDD patients were divided into two groups, those born in spring/summer (n=457) and those born in autumn/winter (n=434). Measurement tools comprising the Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, Brief Psychiatric Rating Scale, Scale for Suicidal Ideation, Clinical Global Impression of severity, Social and Occupation Functional Assessment Scale, WHO Quality of Life assessment instrument-abbreviated version, Alcohol Use Disorder Identification Test, and Temperament and Character Inventory were used to evaluate depression, anxiety, overall symptoms, suicidal ideation, global severity, social function, quality of life, drinking, and temperament and character, respectively. Using independent t-tests for continuous variables and χ² tests for discrete variables, the clinical characteristics of the two groups were compared. MDD patients born in spring/summer were on average younger at onset of first depressive episode (t=2.084, p=0.038), had greater loss of concentration (χ²=4.589, p=0.032), and were more self-directed (t=2.256, p=0.025) than those born in autumn/winter. Clinically, there was a trend for the MDD patients born in spring/summer to display the contradictory characteristics of more severe clinical course and less illness burden; this may have been partly due to a paradoxical effect of the 5-HT system.

  11. The relationship between clinical signs of respiratory system disorders and lung lesions at slaughter in veal calves.

    Science.gov (United States)

    Leruste, H; Brscic, M; Heutinck, L F M; Visser, E K; Wolthuis-Fillerup, M; Bokkers, E A M; Stockhofe-Zurwieden, N; Cozzi, G; Gottardo, F; Lensink, B J; van Reenen, C G

    2012-06-01

    The presence and severity of lung lesions recorded post-mortem is commonly used as an indicator to assess the prevalence of respiratory problems in batches of bovines. In the context of a welfare monitoring based on on-farm measures, the recording of clinical signs on calves at the farm would be more convenient than the recording of lung lesions at slaughter. The aim of the present study was to investigate the relationship between clinical respiratory signs at farm and post-mortem analyses of lung lesions observed at slaughter in veal calves. If clinical signs were a good predictor of lung lesions it could be possible to integrate only those measures in a welfare monitoring system. One-hundred-and-seventy-four batches of calves were observed 3 times: at 3 and 13 weeks after arrival of the calves at the unit and at 2 weeks before slaughter. For each batch a maximum of 300 calves was observed and the proportions of calves showing abnormal breathing, nasal discharge and coughing were recorded. Post-mortem inspection was carried out on a sample of lungs belonging to calves from the observed batches. Each examined lung was classified according to a 4-point scale for pneumonia from healthy lung (score 0) to severe lesions (score 3). The clinical signs recorded infra vitam were significantly correlated with moderate and severe lung lesions for observations at 13 weeks and 2 weeks before slaughter and the level of the correlation was highly variable (r(sp) from 0.16 to 0.40). Receiver operating characteristic (ROC) curves were created and the area under the curves showed that batches with a high proportion of lungs with moderate or severe lesions could not be accurately detected by the three clinical signs of respiratory disorders. These results suggest that both clinical signs and post-mortem inspection of lung lesions must be included in a welfare monitoring schemes for veal calves.

  12. Relationship between clinical signs and postmortem test status in cattle experimentally infected with the bovine spongiform encephalopathy agent

    Directory of Open Access Journals (Sweden)

    Stack Michael J

    2010-12-01

    Full Text Available Abstract Background Various clinical protocols have been developed to aid in the clinical diagnosis of classical bovine spongiform encephalopathy (BSE, which is confirmed by postmortem examinations based on vacuolation and accumulation of disease-associated prion protein (PrPd in the brain. The present study investigated the occurrence and progression of sixty selected clinical signs and behaviour combinations in 513 experimentally exposed cattle subsequently categorised postmortem as confirmed or unconfirmed BSE cases. Appropriate undosed or saline inoculated controls were examined similarly and the data analysed to explore the possible occurrence of BSE-specific clinical expression in animals unconfirmed by postmortem examinations. Results Based on the display of selected behavioural, sensory and locomotor changes, 20 (67% orally dosed and 17 (77% intracerebrally inoculated pathologically confirmed BSE cases and 21 (13% orally dosed and 18 (6% intracerebrally inoculated but unconfirmed cases were considered clinical BSE suspects. None of 103 controls showed significant signs and were all negative on diagnostic postmortem examinations. Signs indicative of BSE suspects, particularly over-reactivity and ataxia, were more frequently displayed in confirmed cases with vacuolar changes in the brain. The display of several BSE-associated signs over time, including repeated startle responses and nervousness, was significantly more frequent in confirmed BSE cases compared to controls, but these two signs were also significantly more frequent in orally dosed cattle unconfirmed by postmortem examinations. Conclusions The findings confirm that in experimentally infected cattle clinical abnormalities indicative of BSE are accompanied by vacuolar changes and PrPd accumulation in the brainstem. The presence of more frequently expressed signs in cases with vacuolar changes is consistent with this pathology representing a more advanced stage of disease. That

  13. Clinical anxiety, cortisol and interleukin-6: evidence for specificity in emotion-biology relationships.

    LENUS (Irish Health Repository)

    O'Donovan, Aoife

    2012-02-01

    Anxiety confers increased risk for inflammatory diseases, and elevated inflammatory activity in anxious individuals may contribute to this increased risk. One complication, however, is that anxiety could be associated with inflammatory activity either through a specific anxiety pathway or through a more general negative emotionality pathway. To investigate, we measured levels of the stress hormone cortisol, the pro-inflammatory cytokine interleukin-6 (IL-6), and the systemic inflammatory marker C-reactive protein (CRP), as well as depression and neuroticism, in clinically anxious and non-anxious adults. Compared with non-anxious participants, clinically anxious participants exhibited significantly lower levels of morning cortisol and significantly higher levels of IL-6, independent of age, sex, and depressive symptoms. These group differences were robust when controlling for neuroticism. Conversely, the groups had equivalent levels of CRP in all analyses. Results are indicative of anxiety-specific effects on inflammatory activity, and highlight a pathway by which anxiety may increase risk for inflammatory diseases.

  14. Relationship between drug interactions and drug-related negative clinical outcomes in two community pharmacies

    Directory of Open Access Journals (Sweden)

    Gonzalo M

    2009-03-01

    Full Text Available Drug interactions may represent an iatrogenic risk that should be controlled in community pharmacies at the dispensing level. Aim: We analyzed the association between potential drug-drug interactions (DDIs and negative clinical outcomes.Methods: We used dispensing data from two community pharmacies: instances where drug dispensing was associated with a potential DDI and a comparison group of randomized dispensing operations with no potential DDI. In cases where potential DDIs were detected, we analyzed the underlying negative clinical outcomes. Age and gender data were included in the analysis.Results: During the study period, we registered 417 potential DDIs. The proportion of women and age were higher in the study group than in the comparison group. The average potential DDIs per patient was 1.31 (SD=0.72. The Consejo General de Colegios Oficiales de Farmacéuticos (CGCOF database did not produce an alert in 2.4% of the cases. Over-the-counter medication use was observed in 5% of the potential DDI cases. The drugs most frequently involved in potential DDIs were acenocoumarol, calcium salts, hydrochlorothiazide, and alendronic acid, whereas the most predominant potential DDIs were calcium salts and bisphosphonates, oral antidiabetics and thiazide diuretics, antidiabetics and glucose, and oral anticoagulant and paracetamol. The existence of a drug-related negative clinical outcome was observed only in 0.96% of the potential DDI cases (50% safety cases and 50% effectiveness cases. Conclusions: Only a small proportion of the detected potential DDIs lead to medication negative outcomes. Considering the drug-related negative clinical outcomes encountered, tighter control would be recommended in potential DDIs with NSAIDs or benzodiazepines.

  15. The relationship between sleep and epilepsy: evidence from clinical trials and animal models.

    Science.gov (United States)

    Matos, Gabriela; Andersen, Monica L; do Valle, Angela Cristina; Tufik, Sergio

    2010-08-15

    Interactions between sleep and epilepsy have been widely documented. Sleep can modulate epileptic phenomena, and epilepsy and seizures disorganize the macro- and micro-architecture of sleep. In turn, sleep deprivation exerts a strong influence on the occurrence of seizures and interictal epileptiform discharges. Recently, sleep disturbances occurring in conjunction with epilepsy have been suggested to lead to a worsening of the quality of life for patients with epilepsy. In addition, data from animal models clarify many gaps in this relationship. In this brief review, we present an outline of the interactions between sleep and epilepsy based on a thorough review of the existing literature.

  16. Relationship between the expression of matrix metalloproteinase-9 and angiogenesis in glioma and its clinical significance

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Objective To explore the role and significance of matrix metalloproteinase-9(MMP-9)in angiogenesis through observing the relationship between the expression of MMP-9 and microvessel density(MVD)in glioma.Methods The expressions of MMP-9 and CD34 in 10 cases of normal brain tissues and 58 cases of glioma(14 cases of grade Ⅰ,20 cases of grade Ⅱ,15 cases of grade Ⅲ,and 9 cases of grade Ⅳ)were detected by immunohistochemical streptavidin-peroxidase technique.The positive cells of MMP-9 and the positive microves...

  17. Relationship Between Patient-Reported Outcomes and Clinical Outcomes in Patients With Morquio A Syndrome

    Directory of Open Access Journals (Sweden)

    Christina Lampe MD

    2015-04-01

    Full Text Available This cross-sectional analysis assessed the correlation between patient-reported outcomes (PROs and clinical outcomes in 24 German patients with Morquio A. Clinical outcomes included 6-minute walk test (6MWT, 3-minute stair climb (3MSC test, and joint range of motion as measures for endurance/mobility, forced vital capacity (FVC and maximum voluntary ventilation (MVV as measures for respiratory function, and height as an important manifestation. The PROs included the EuroQoL (EQ 5D-5L (EQ5D-5L, to measure health-related QoL (HRQoL, and patients’ rating of their ability to walk, climb, or breathe. In adults, endurance and pulmonary function measures and height showed strong and statistically significant correlation with the patients’ EQ5D-5L (6MWT: R = .884, 3MSC test: R = .852, FVC: R = .815, MVV: R = .825, height: R = .842. The adult patients’ rating of their ability to walk and climb also correlated strongly with 6MWT (R = .839 and 3MSC test (R = .700 results. Improvements in these clinical outcomes may be robust surrogate parameters of a better EQ5D-5L/HRQoL in patients with Morquio A.

  18. Relationship between energy expenditure, nutritional status and clinical severity before starting enteral nutrition in critically ill children.

    Science.gov (United States)

    Botrán, Marta; López-Herce, Jesús; Mencía, Santiago; Urbano, Javier; Solana, Maria José; García, Ana; Carrillo, Angel

    2011-03-01

    The objective of the present study was to investigate the relationship between energy expenditure (EE), biochemical and anthropometric nutritional status and severity scales in critically ill children. We performed a prospective observational study in forty-six critically ill children. The following variables were recorded before starting nutrition: age, sex, diagnosis, weight, height, risk of mortality according to the Paediatric Risk Score of Mortality (PRISM), the Revised Paediatric Index of Mortality (PIM2) and the Paediatric Logistic Organ Dysfunction (PELOD) scales, laboratory parameters (albumin, total proteins, prealbumin, transferrin, retinol-binding protein, cholesterol and TAG, and nitrogen balance) and EE measured by indirect calorimetry. The results showed that there was no relationship between EE and clinical severity evaluated using the PRISM, PIM2 and PELOD scales or with the anthropometric nutritional status or biochemical alterations. Finally, it was concluded that neither nutritional status nor clinical severity is related to EE. Therefore, EE must be measured individually in each critically ill child using indirect calorimetry.

  19. The relationship between temperament and autistic traits in a non-clinical students sample.

    Directory of Open Access Journals (Sweden)

    Ewa Pisula

    Full Text Available Since temperament affects the development of social behaviours and interpersonal relations, the possible links between autistic traits and temperament are of particular interest. The purpose of the study was to explore the relationships between autistic traits and temperamental characteristics in the framework of the Regulative Temperament Theory by Strelau, and the Emotionality, Activity and Sociability theory by Buss and Plomin, with particular emphasis on gender differences. The Autism Spectrum Quotient (AQ, Formal Characteristics of Behaviour--Temperament Inventory and Temperament Survey for Adults were administered. The participants were 593 university students, including 364 females and 229 males. Results showed positive correlations between autistic traits and Emotional Reactivity, Perseveration, Distress, Fear and Anger, and negative correlations with Activity, Briskness, Endurance and Sociability. The results of multiple regression analyses involving the Autism Spectrum Quotient score as a dependent measure were different for females and males. Results of exploratory PCA analysis showed that AQ score, Sociability and Activity loaded one factor (with AQ loading being opposite to two others. High AQ scorers demonstrated higher Emotional Reactivity, Perseveration, Distress and Anger, and lower Briskness, Endurance, Activity and Sociability as compared to norms for the general population. In this study we showed that temperament measures were able to identify items that correlated in parts with autistic traits, while other items were obverse. The relationships between temperament and autistic traits differ slightly between genders. We assume that with regard to the broader autism phenotype, temperaments might be helpful in characterizing healthy control samples.

  20. Relationship between cannabis and psychosis: Reasons for use and associated clinical variables.

    Science.gov (United States)

    Mané, Anna; Fernández-Expósito, Miguel; Bergé, Daniel; Gómez-Pérez, Laura; Sabaté, Agnés; Toll, Alba; Diaz, Laura; Diez-Aja, Cristobal; Perez, Victor

    2015-09-30

    The mechanism underneath the relationship between cannabis and psychosis remains controversial, for which several hypotheses have been proposed, including cannabis as self-medication and cannabis as a risk for the development of psychosis. The aim of this work was to study the relationship between cannabis and psychosis in first-episode psychosis cannabis users and non-users, and non-psychotic cannabis users. The age at the first psychotic episode, duration of untreated psychosis, psychopathology and reasons for cannabis use were assessed. First-episode psychosis cannabis users showed an earlier age at psychosis onset than non-user patients. No significant differences in symptomatology were found. The distinguishing reasons to use cannabis for patients with first-episode psychosis with respect to non-psychotic users were to arrange their thoughts and deal with hallucinations and suspiciousness. These findings are in agreement with both hypotheses: self-medication and secondary psychosis hypothesis. However, longitudinal prospective cohort studies assessing reasons for cannabis use are needed to investigate both hypotheses and their complementarity.

  1. Performance-based interpretation bias in clinically anxious youths: relationships with attention, anxiety, and negative cognition.

    Science.gov (United States)

    Rozenman, Michelle; Amir, Nader; Weersing, V Robin

    2014-09-01

    This preliminary investigation sought to examine basic interpretive biases, as assessed via performance-based means, in the context of anxious symptomatology, attention, and negative cognition in children and adolescents. At a single assessment, 26 youths diagnosed with primary separation anxiety, social phobia, or generalized anxiety disorder completed performance-based assessments of interpretation and attention. Youths and parents also completed diagnostic interviews and youths completed a measure of negative self-statements. Components of interpretation (threat-valence judgments and speed of responding) were examined, and interpretation was explored as a correlate of youth anxiety, attention bias, and negative self-statements. Results found percentage of negative interpretations endorsed as the strongest predictor of anxiety symptoms; this index was also correlated with attention bias. Slower rejection of benign interpretations was also associated with youth-reported negative self-statements.This initial investigation provides support for a relationship between interpretation bias and anxiety and preliminary evidence for a relationship between attention and interpretation biases. Continued research dismantling the stages of basic cognition within the chain of information processing may provide a better understanding of the mechanisms underlying anxiety disorders in youths and lead to continued development and refinement of cognitive interventions.

  2. The relationship between temperament and autistic traits in a non-clinical students sample.

    Science.gov (United States)

    Pisula, Ewa; Kawa, Rafał; Danielewicz, Dorota; Pisula, Wojciech

    2015-01-01

    Since temperament affects the development of social behaviours and interpersonal relations, the possible links between autistic traits and temperament are of particular interest. The purpose of the study was to explore the relationships between autistic traits and temperamental characteristics in the framework of the Regulative Temperament Theory by Strelau, and the Emotionality, Activity and Sociability theory by Buss and Plomin, with particular emphasis on gender differences. The Autism Spectrum Quotient (AQ), Formal Characteristics of Behaviour--Temperament Inventory and Temperament Survey for Adults were administered. The participants were 593 university students, including 364 females and 229 males. Results showed positive correlations between autistic traits and Emotional Reactivity, Perseveration, Distress, Fear and Anger, and negative correlations with Activity, Briskness, Endurance and Sociability. The results of multiple regression analyses involving the Autism Spectrum Quotient score as a dependent measure were different for females and males. Results of exploratory PCA analysis showed that AQ score, Sociability and Activity loaded one factor (with AQ loading being opposite to two others). High AQ scorers demonstrated higher Emotional Reactivity, Perseveration, Distress and Anger, and lower Briskness, Endurance, Activity and Sociability as compared to norms for the general population. In this study we showed that temperament measures were able to identify items that correlated in parts with autistic traits, while other items were obverse. The relationships between temperament and autistic traits differ slightly between genders. We assume that with regard to the broader autism phenotype, temperaments might be helpful in characterizing healthy control samples.

  3. The relationship between Vitamin D, clinical outcomes and mortality rate in ICU patients: A prospective observational study

    Science.gov (United States)

    Vosoughi, Nooshin; Kashefi, Parviz; Abbasi, Behnood; Feizi, Awat; Askari, Gholamreza; Azadbakht, Leila

    2016-01-01

    Background: According to the high prevalence of Vitamin D deficiency, a few studies have been conducted to clarify the relationship between 25-hydroxyvitamin D (25(OH)D) and clinical outcomes in critically ill patients. The objective of this study was to determine this probable association. Materials and Methods: Serum 25(OH)D, C-reactive protein, malnutrition measurements, and Intensive Care Unit (ICU)-acquired infection from 185 patients in ICU were assessed in the first 24 h of admission and they were followed for the other outcomes. Results: About 93.5% of patients were classified as deficient and insufficient while the others were categorized in sufficient group. 25(OH)D status was not significantly associated with mortality rate (P = 0.66), and no significant differences in ventilation time were observed (P = 0.97). Sufficient group left the ICU sooner, but the difference was not significant (P = 0.75). Besides the results of relationship between 25(OH)D concentration and nutritional status (P = 0.69) were not significant. In addition, sufficient group suffered from infection more than insufficient patients, but this relationship was not significant (P = 0.11). Conclusion: In this study, we found that 25(OH)D insufficiency is common in ICU patients, but no significant association between low 25(OH)D levels and ICU outcomes were observed. Hence, because of vital roles of Vitamin D in human's body, comprehensive study should conduct to determine the decisive results. PMID:27904620

  4. The relationship between Vitamin D, clinical outcomes and mortality rate in ICU patients: A prospective observational study

    Directory of Open Access Journals (Sweden)

    Nooshin Vosoughi

    2016-01-01

    Full Text Available Background: According to the high prevalence of Vitamin D deficiency, a few studies have been conducted to clarify the relationship between 25-hydroxyvitamin D (25(OHD and clinical outcomes in critically ill patients. The objective of this study was to determine this probable association. Materials and Methods: Serum 25(OHD, C-reactive protein, malnutrition measurements, and Intensive Care Unit (ICU-acquired infection from 185 patients in ICU were assessed in the first 24 h of admission and they were followed for the other outcomes. Results: About 93.5% of patients were classified as deficient and insufficient while the others were categorized in sufficient group. 25(OHD status was not significantly associated with mortality rate (P = 0.66, and no significant differences in ventilation time were observed (P = 0.97. Sufficient group left the ICU sooner, but the difference was not significant (P = 0.75. Besides the results of relationship between 25(OHD concentration and nutritional status (P = 0.69 were not significant. In addition, sufficient group suffered from infection more than insufficient patients, but this relationship was not significant (P = 0.11. Conclusion: In this study, we found that 25(OHD insufficiency is common in ICU patients, but no significant association between low 25(OHD levels and ICU outcomes were observed. Hence, because of vital roles of Vitamin D in human′s body, comprehensive study should conduct to determine the decisive results.

  5. Detangling complex relationships in forensic data: principles and use of causal networks and their application to clinical forensic science.

    Science.gov (United States)

    Lefèvre, Thomas; Lepresle, Aude; Chariot, Patrick

    2015-09-01

    The search for complex, nonlinear relationships and causality in data is hindered by the availability of techniques in many domains, including forensic science. Linear multivariable techniques are useful but present some shortcomings. In the past decade, Bayesian approaches have been introduced in forensic science. To date, authors have mainly focused on providing an alternative to classical techniques for quantifying effects and dealing with uncertainty. Causal networks, including Bayesian networks, can help detangle complex relationships in data. A Bayesian network estimates the joint probability distribution of data and graphically displays dependencies between variables and the circulation of information between these variables. In this study, we illustrate the interest in utilizing Bayesian networks for dealing with complex data through an application in clinical forensic science. Evaluating the functional impairment of assault survivors is a complex task for which few determinants are known. As routinely estimated in France, the duration of this impairment can be quantified by days of 'Total Incapacity to Work' ('Incapacité totale de travail,' ITT). In this study, we used a Bayesian network approach to identify the injury type, victim category and time to evaluation as the main determinants of the 'Total Incapacity to Work' (TIW). We computed the conditional probabilities associated with the TIW node and its parents. We compared this approach with a multivariable analysis, and the results of both techniques were converging. Thus, Bayesian networks should be considered a reliable means to detangle complex relationships in data.

  6. Comorbidity of Anxiety Disorders and Substance Abusewith Bipolar Mood Disorders and Relationship with ClinicalCourse

    Directory of Open Access Journals (Sweden)

    Ali Reza Shafiee-Kandjani

    2009-12-01

    Full Text Available "n Objective: Patients with bipolar mood disorder constitute a relatively large number of individuals hospitalized in psychiatric hospitals. This disorder is highly co-morbid with other psychiatric disorders and may effect their clinical course. The goal of this study was to determine the co-occurrence rate of anxiety disorders and substance abuse with bipolar mood disorders and their impact on clinical course. "n Methods: 153 bipolar patients (type I were selected among the hospitalized patients at Razi Psychiatric Hospital in Tabriz, Iran, from September 2007 to October 2008 through convenience sampling method. The participants were evaluated by a structured clinical interview based on DSM-IV criteria (SCID, Hamilton Rating Scale for Depression (HRSD and Young Mania Rating Scale (YMRS. Results: Co-morbidity of anxiety disorders was 43% . Occurrence of anxiety disorders was 26% for obsessive-compulsive disorder, 24.8% for generalized anxiety disorder, 3.9% for phobia and 2% for panic disorder. Co-morbidity of substance abuse was 7.2% and the highest occurrence of substance abuse was 5.2% for alcoholism and 3.9% for opium. No significant difference was observed between the severity of disease and duration of hospitalization in bipolar patients with or without anxiety disorder. The severity of disease and duration of hospitalization in bipolar patients with substance abuse was higher compared to bipolar patients without substance abuse (P<0.05. "nConclusions: This study suggests that there is a high co-morbidity between anxiety disorders and substance abuse with bipolar disorder. Further, this study suggests that co-occurrence of substance abuse disorder with bipolar disorder increases the severity of the disease and duration of hospitalization.

  7. Application of texture analysis to DAT SPECT imaging: Relationship to clinical assessments

    Directory of Open Access Journals (Sweden)

    Arman Rahmim

    2016-01-01

    Full Text Available Dopamine transporter (DAT SPECT imaging is increasingly utilized for diagnostic purposes in suspected Parkinsonian syndromes. We performed a cross-sectional study to investigate whether assessment of texture in DAT SPECT radiotracer uptake enables enhanced correlations with severity of motor and cognitive symptoms in Parkinson's disease (PD, with the long-term goal of enabling clinical utility of DAT SPECT imaging, beyond standard diagnostic tasks, to tracking of progression in PD. Quantitative analysis in routine DAT SPECT imaging, if performed at all, has been restricted to assessment of mean regional uptake. We applied a framework wherein textural features were extracted from the images. Notably, the framework did not require registration to a common template, and worked in the subject-native space. Image analysis included registration of SPECT images onto corresponding MRI images, automatic region-of-interest (ROI extraction on the MRI images, followed by computation of Haralick texture features. We analyzed 141 subjects from the Parkinson's Progressive Marker Initiative (PPMI database, including 85 PD and 56 healthy controls (HC (baseline scans with accompanying 3 T MRI images. We performed univariate and multivariate regression analyses between the quantitative metrics and different clinical measures, namely (i the UPDRS (part III - motor score, disease duration as measured from (ii time of diagnosis (DD-diag. and (iii time of appearance of symptoms (DD-sympt., as well as (iv the Montreal Cognitive Assessment (MoCA score. For conventional mean uptake analysis in the putamen, we showed significant correlations with clinical measures only when both HC and PD were included (Pearson correlation r = −0.74, p-value < 0.001. However, this was not significant when applied to PD subjects only (r = −0.19, p-value = 0.084, and no such correlations were observed in the caudate. By contrast, for the PD subjects, significant correlations

  8. Whole genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing

    Science.gov (United States)

    Harris, Simon R.; Clarke, Ian N.; Seth-Smith, Helena M. B.; Solomon, Anthony W.; Cutcliffe, Lesley T.; Marsh, Peter; Skilton, Rachel J.; Holland, Martin J.; Mabey, David; Peeling, Rosanna W.; Lewis, David A.; Spratt, Brian G.; Unemo, Magnus; Persson, Kenneth; Bjartling, Carina; Brunham, Robert; de Vries, Henry J.C.; Morré, Servaas A.; Speksnijder, Arjen; Bébéar, Cécile M.; Clerc, Maïté; de Barbeyrac, Bertille; Parkhill, Julian; Thomson, Nicholas R.

    2012-01-01

    Chlamydia trachomatis is responsible for both trachoma and sexually transmitted infections causing substantial morbidity and economic cost globally. Despite this, our knowledge of its population and evolutionary genetics is limited. Here we present a detailed whole genome phylogeny from representative strains of both trachoma and lymphogranuloma venereum (LGV) biovars from temporally and geographically diverse sources. Our analysis demonstrates that predicting phylogenetic structure using the ompA gene, traditionally used to classify Chlamydia, is misleading because extensive recombination in this region masks true relationships. We show that in many instances ompA is a chimera that can be exchanged in part or whole, both within and between biovars. We also provide evidence for exchange of, and recombination within, the cryptic plasmid, another important diagnostic target. We have used our phylogenetic framework to show how genetic exchange has manifested itself in ocular, urogenital and LGV C. trachomatis strains, including the epidemic LGV serotype L2b. PMID:22406642

  9. Molecular relationship among fosfomycin-resistant plasmids and clinical impact of fosfomycin resistance.

    Science.gov (United States)

    Mendoza, M C; Teran, F J; Mendez, F J; Hardisson, C

    1988-10-01

    We have been carrying out a surveillance programme on plasmid-mediated fosfomycin resistance in our community over the last decade and have isolated and characterized several varieties of conjugative plasmids from different enterobacteriae. In this work we show that seven varieties of plasmids are related with the Inc M group, and carry the same For determinant which encodes a modifying enzyme. The comparative study on their R-phenotype, restriction analysis and DNA-DNA hybridization showed different degrees of molecular relationship among them. The spread of For-plasmids as well as the fosfomycin resistance by other mechanisms seems to be low in spite of the great For-plasmid diversity found.

  10. [Diabetes mellitus and periodontitis. Bidirectional relationship and clinical implications. A consensus document].

    Science.gov (United States)

    Deschner, J; Haak, T; Jepsen, S; Kocher, T; Mehnert, H; Meyle, J; Schumm-Draeger, P-M; Tschöpe, D

    2011-04-01

    Diabetes and periodontitis are chronic diseases with an increasing prevalence in the German population. There is a bi-directional relationship between both diseases. Diabetes promotes the occurrence, the progression and the severity of periodontitis. Periodontitis complicates the glycemic control of diabetes, increases the risk of diabetes-associated complications and possibly even of its onset. In view of the existing evidence, that is still not sufficiently communicated within the medical community, an expert panel consisting of four diabetologists and four periodontists has addressed the following questions: What is the effect of diabetes mellitus on periodontitis and on periodontal therapy? What is the effect of periodontitis on diabetes mellitus? What are the practical consequences, that result for interdisciplinary treatment strategies? The treatment of periodontal infections should become an integral part of the management of diabetes, whereas glycemic control is a prerequisite for successful periodontal therapy.

  11. Delineation of Streptococcus dysgalactiae, its subspecies, and its clinical and phylogenetic relationship to Streptococcus pyogenes

    DEFF Research Database (Denmark)

    Jensen, Anders; Kilian, Mogens

    2011-01-01

    The close phylogenetic relationship of the important pathogen Streptococcus pneumoniae and several species of commensal streptococci, particularly Streptococcus mitis and Streptococcus pseudopneumoniae, and the recently demonstrated sharing of genes and phenotypic traits previously considered...... specific for S. pneumoniae hamper the exact identification of S. pneumoniae. Based on sequence analysis of 16S rRNA genes of a collection of 634 streptococcal strains, identified by multilocus sequence analysis, we detected a cytosine at position 203 present in all 440 strains of S. pneumoniae but replaced...... by an adenosine residue in all strains representing other species of mitis group streptococci. The S. pneumoniae-specific sequence signature could be demonstrated by sequence analysis or indirectly by restriction endonuclease digestion of a PCR amplicon covering the site. The S. pneumoniae-specific signature...

  12. The emerging relationship between the airway microbiota and chronic respiratory disease: clinical implications.

    Science.gov (United States)

    Huang, Yvonne J; Lynch, Susan V

    2011-12-01

    Until recently, relationships between evidence of colonization or infection by specific microbial species and the development, persistence or exacerbation of pulmonary disease have informed our opinions of airway microbiology. However, recent applications of culture-independent tools for microbiome profiling have revealed a more diverse microbiota than previously recognized in the airways of patients with chronic pulmonary disease. New evidence indicates that the composition of airway microbiota differs in states of health and disease and with severity of symptoms and that the microbiota, as a collective entity, may contribute to pathophysiologic processes associated with chronic airway disease. Here, we review the evolution of airway microbiology studies of chronic pulmonary disease, focusing on asthma, chronic obstructive pulmonary disease and cystic fibrosis. Building on evidence derived from traditional microbiological approaches and more recent culture-independent microbiome studies, we discuss the implications of recent findings on potential microbial determinants of respiratory health or disease.

  13. Temporary brittle bone disease: relationship between clinical findings and judicial outcome

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    Colin R. Paterson

    2011-10-01

    Full Text Available There is a wide differential diagnosis for the child with unexplained fractures including non-accidental injury, osteogenesis imperfecta and vitamin D deficiency rickets. Over the last 20 years we and others have described a self-limiting syndrome characterised by fractures in the first year of life. This has been given the provisional name temporary brittle bone disease. This work had proved controversial mostly because the fractures, including rib fractures and metaphyseal fractures, were those previously regarded as typical or even diagnostic of non-accidental injury. Some have asserted that the condition does not exist. Over the years 1985 to 2000 we investigated 87 such cases with fractures with a view to determining the future care of the children. In 85 of these the judiciary was involved. We examined the clinical and radiological findings in the 33 cases in which there was a judicial finding of abuse, the 24 cases in which the parents were exonerated and the 28 cases in which no formal judicial finding was made. The three groups of patients were similar in terms of demographics, age at fracturing and details of the fractures. The clinical similarities between the three groups of patients contrasts with the very different results of the judicial process.

  14. Osteoarthritis in horses - Part 1: relationship between clinical and radiographic examination for the diagnosis

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    Maria Verônica de Souza

    Full Text Available ABSTRACT Locomotor disorders are very common in the equine clinic, which may be partly due to the different types of activities horses develop. Osteoarthritis (OA, commonly known as degenerative joint disease, presents an considerable role in the series of disorders of the musculoskeletal system and may be associated with other problems such as navicular syndrome, periostitis or osteochondrosis. This affection causes progressive deterioration of articular cartilage, accompanied by bone and soft-tissue periarticular changes. In fact, it results from a complex interaction between biochemical and biomechanical factors. The objective of this article is to review information about clinical and radiographic findings of OA, the biochemical and biomechanical changes manifested in the disease and the importance of the synovial fluid. Additionally, some information on other species is also presented. This review refers to Part 1 of a study whose sequence is entitled "Osteoarthritis in horses - Part 2: a review of the intra-articular use of corticosteroids as a method of treatment."

  15. Genetic diversity and evolutionary relationships among Legionella pneumophila clinical isolates, Portugal, 1987 to 2012.

    Science.gov (United States)

    Chasqueira, M J; Rodrigues, L; Nascimento, M; Ramos, M; Marques, T

    2014-11-20

    The genetic diversity of 89 clinical Legionella isolates, collected between 1987 and 2012, in 22 hospitals from the five regions of Portugal, was analysed in this study using monoclonal antibodies (MAbs) of the Dresden panel and the sequence-based typing (SBT) protocol. The eBURST algorithm was used to infer levels of relatedness between isolates. All isolates collected were Legionella pneumophila, which were further characterised into four subgroups by MAbs, and 30 sequence types (STs) by SBT. Twelve of the STs were unique to Portugal; one of them (ST100) was represented by 32 epidemiologically related isolates. The ST44 was the profile with the highest number of epidemiologically unrelated isolates. The eBURST analyses indicate that, within the group formed by the 30 STs identified in this study, 17 STs were genetically close to at least another ST in the group. The comparison between the eBURST diagrams obtained with the STs from this study and the entire SBT database of the European Working Group for Legionella, showed that 24 (seven of them unique to Portugal) of our 30 STs were related with STs identified in others countries. These results suggest that the population of L. pneumophila clinical strains in Portugal includes both worldwide and local strains.

  16. Relationship between Clinical and Immunological Features of Thyroid Autoimmunity and Ophthalmopathy during Pregnancy

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    Jack R. Wall

    2015-01-01

    Full Text Available Problem. Clinical features of Graves’ hyperthyroidism (GH generally improve during pregnancy and rebound in the postpartum period. It is unclear whether the ophthalmopathy that is associated with GH and, less often, Hashimoto’s thyroiditis (HT changes in parallel with the thyroid associated antibody reactions and clinical features or runs a different course. Method of Study. We retrospectively studied 19 patients with autoimmune thyroid disease over 22 pregnancies: 9 pregnancies with GH and 13 with HT. Ophthalmopathy was defined by NOSPECS class. Results. Thyroid peroxidase (TPO and thyroglobulin (Tg antibody titres decreased during pregnancy and rose in the postpartum period. During pregnancy, 5 patients with GH and 4 patients with HT developed mild ophthalmopathy and two patients with GH and HT developed new upper eyelid retraction (UER. In the postpartum period, eye scores improved in 3 patients with GH and 3 with HT, remained stable in two and 5 patients, respectively, and worsened in 2 patients with GH and one with HT. Conclusions. In patients with mild to moderate eye signs associated with GH and HT, the orbital and thyroid reactions ran different courses during pregnancy. Since no patient had severe ophthalmopathy, we cannot draw definitive conclusions from this preliminary study.

  17. Understanding the relationship between the perceived characteristics of clinical practice guidelines and their uptake: protocol for a realist review

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    Grimshaw Jeremy

    2011-07-01

    Full Text Available Abstract Background Clinical practice guidelines have the potential to facilitate the implementation of evidence into practice, support clinical decision making, specify beneficial therapeutic approaches, and influence public policy. However, these potential benefits have not been consistently achieved. The limited impact of guidelines can be attributed to organisational constraints, the complexity of the guidelines, and the lack of usability testing or end-user involvement in their development. Implementability has been referred to as the perceived characteristics of guidelines that predict the relative ease of their implementation at the clinical level, but this concept is as yet poorly defined. The objective of our study is to identify guideline attributes that affect uptake in practice by considering evidence from four disciplines (medicine, psychology, management, human factors engineering to determine the relationship between the perceived characteristics of recommendations and their uptake and to develop a framework of implementability. Methods A realist-review approach to knowledge synthesis will be used to understand attributes of guidelines (e.g., its text and content and how changing these elements might impact clinical practice and clinical decision making. It also allows for the exploration of 'what works for whom, in what circumstances, and in what respects'. The realist review will be structured according to Pawson's five practical steps in realist reviews: (1 clarifying the scope of the review, (2 determining the search strategy, (3 ensuring proper article selection and study quality assessment, (4 extracting and organising data, and (5 synthesising the evidence and drawing conclusions. Data will be synthesised according to a two-stage analysis: (1 we will extract and define all relevant guideline attributes from the different disciplines, then create a shortlist of unique attributes and investigate their relationships with

  18. Reinitiating Warfarin: Relationships Between Dose and Selected Patient, Clinical and Hospital Measures

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    Leonhard, Lucas G.; Berg, Richard L.; Burmester, James K.; Mazza, Joseph J.; Schmelzer, John R.; Yale, Steven H.

    2015-01-01

    Background Warfarin is an oral anticoagulant used in the long-term treatment/prevention of venothromboembolic disease. Patients undergoing elective surgical and non-surgical procedures may require temporary warfarin discontinuation followed by reinitiation after their procedure. Because little information is available regarding best methods for warfarin reinitiation, we investigated current practices to inform management decisions. Methods Subjects were required to have a known and stable warfarin dose prior to discontinuation, which was operationalized by requiring, within 7-days prior to discontinuation, that they have at least one INR in therapeutic range (2.0–3.5), no INR(s) out of range, and no more than a 15% change in warfarin dose. Stable dose prior to discontinuation was defined as the average daily dose received in the 7 days immediately prior to discontinuation. Reinitiation dose was defined as the average daily dose received in the first 3 days after warfarin was restarted. Subjects were divided into three groups based on whether they received approximately the same, a higher, or a lower dose at reinitiation and were also grouped by calendar time into three distinct periods that reflected differing levels of availability of electronic and patient care data that may impact reinitiation dose decisions. These groupings facilitated analyses and descriptions of trends in reinitiation dosing and supported other analyses, including tests for association between dose group and selected subject demographic, clinical, medication and hospitalization measures. All study data were abstracted from Marshfield Clinic electronic patient care and administrative databases and electronic patient care databases from Ministry St. Joseph’s Hospital (Marshfield, WI). Results We identified 205 subjects with warfarin temporarily discontinued between 1994 and 2012: 99 subjects in same dose group, 32 subjects in the low group, and 74 subjects in the high group. Because

  19. Performance-based quality specifications: the relationship between process critical control parameters, critical quality attributes, and clinical performance.

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    Short, Steven M; Cogdill, Robert P; Drennen, James K; Anderson, Carl A

    2011-04-01

    The quality of pharmaceutical products is currently evaluated through a series of tests that do not explicitly communicate the clinical consequences of product variability. A previously published risk simulation platform was used to generate quantitative estimates of inefficacy and toxicity for 288 uniform lots of extended-release theophylline tablets displaying various levels of content uniformity and dissolution variability. These data were used to evaluate the univariate specifications utilized in the United States Pharmacopeia (USP) and . Simulation revealed that the specifications are too lenient for content uniformity, both in terms of inefficacy and toxicity, whereas the criteria for dissolution testing are too strict for inefficacy and inaccurate for toxicity. The USP tests also failed to pinpoint the clinical interaction between content uniformity and dissolution variability. Additionally, the simulation platform was used to define the underlying relationship between product quality attributes and clinical performance. Here, content uniformity and Weibull dissolution time constants were used as inputs to the design spaces, which were conditioned on quantitative estimates of inefficacy and toxicity. This methodology enhances the information content of the design space by omitting quality surrogates (e.g., dissolution, moisture content) that are utilized in current design space practices.

  20. Staff perception of interprofessional working relationships after a work redesign intervention in a Danish orthopaedic hand unit outpatient clinic.

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    de Beijer, Anke Elisabeth; Hansen, Torben Bæk; Stilling, Maiken; Jakobsen, Flemming

    2016-01-01

    There is evidence that clinical pathways improve quality of care; however, knowledge is limited concerning the influence on and the benefits experienced by the interprofessional teams working with these pathways. Our working methods in a hand unit in an orthopaedic outpatient clinic in Denmark were redesigned to include, among other changes, the introduction of clinical pathways. Changes included standardising treatment and communication methods, delegating tasks from medical specialists to nurses, and providing nurses with their own consultation room. Using focus group interviews before and after the implementation of the new working methods, we investigated staff-perceived experiences of the effects on working relationships and the utilisation of professional skills and attitudes, resulting from the mentioned change in working methods. The results were changes in daily communication methods among healthcare staff and improvements in the actual communication and collaborative problem solving skills concerning standard patients with simple hand pathology; however, there are still challenges for patients with more complex hand pathology. Though this new interprofessional arrangement improves the use of nurse and medical specialist professional competencies, it also requires a high degree of trust among the team members.

  1. Proliferating cell nuclear antigen immunostaining in breast carcinoma and its relationship to clinical and pathological variables.

    Science.gov (United States)

    Agarwal, S; Jain, R; Rusia, U; Gupta, R L

    1997-01-01

    Tumour proliferative activity of 74 breast lesions was assessed by determining mitotic index and immunostaining for proliferative cell nuclear antigen using Peroxidase antiperoxidase method. The indices were correlated with histomorphology and clinical stage of the disease. Positively stained nuclei and mitotic figures were counted per 1000 cells to calculate Proliferating Cell Nuclear Antigen (PCNA) and mitotic index respectively. Sixty four cases stained positive for PCNA. The index ranged between 0 to 98. PCNA index was significantly low in benign lesions as compared to malignant lesions (p < 0.0002). There was a linear correlation between the mitotic index and PCNA index. PCNA index also showed significant correlation with tumour size and histologic grade; however, it had no correlation with axillary lymph node status.

  2. The relationship between religious involvement and clinical status of patients with bipolar disorder

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    Cruz, Mario; Pincus, Harold Alan; Welsh, Deborah E; Greenwald, Devra; Lasky, Elaine; Kilbourne, Amy M

    2009-01-01

    Objective Religion and spirituality are important coping strategies in depression but have been rarely studied within the context of bipolar disorder. The present study assessed the association between different forms of religious involvement and the clinical status of individuals treated for bipolar disorder. Methods A cross-sectional observation study of follow-up data from a large cohort study of patients receiving care for bipolar disorder (n = 334) at an urban Veterans Affairs mental health clinic was conducted. Bivariate and multivariate analyses were performed to assess the association between public (frequency of church attendance), private (frequency of prayer/meditation), as well as subjective forms (influence of beliefs on life) of religious involvement and mixed, manic, depressed, and euthymic states when demographic, anxiety, alcohol abuse, and health indicators were controlled. Results Multivariate analyses found significant associations between higher rates of prayer/meditation and participants in a mixed state [odds ratio (OR) = 1.29; 95% confidence interval (CI) = 1.10-1.52, chi square = 9.42, df = 14, p < 0.05], as well as lower rates of prayer/meditation and participants who were euthymic (OR = 0.84; 95% CI = 0.72-0.99, chi square = 4.60, df = 14, p < 0.05). Depression and mania were not associated with religious involvement. Conclusions Compared to patients with bipolar disorder in depressed, manic, or euthymic states, patients in mixed states have more active private religious lives. Providers should assess the religious activities of individuals with bipolar disorder in mixed states and how they may complement/deter ongoing treatment. Future longitudinal studies linking bipolar states, religious activities, and treatment-seeking behaviors are needed. PMID:20148868

  3. Relationship of premenstrual syndrome and premenstrual dysphoric disorder with major depression: Relevance to clinical practice

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    Susanta Kumar Padhy

    2015-01-01

    Full Text Available Background: Premenstrual syndrome (PMS, premenstrual dysphoric disorder (PMDD and depressive disorder are fairly common; symptoms do overlap, often under-identified and under-emphasized, particularly in rural India. Objective: The objective was to assess the occurrence of PMS and PMDD in a sample of students and staff of a nursing college and to find their correlation with depression. Materials and Methods: A prospective cohort study; Tertiary Care Hospital in Rural India (Wardha, Maharashtra; 118 female nursing students or staff aged between 18 and 40 years, who were likely to stay within the institution for the study period. The participants were rated on Penn daily symptom report prospectively for a period of 3-month. Those who scored positive were applied diagnostic and statistical manual of mental disorders, 4 th edition, text revision (DSM-IV TR criteria for PMDD; and were applied primary care evaluation of mental disorders depression screening followed by DSM-IV TR criteria for depression. Severity of depression was measured using Hamilton Depression Rating Scale. Results: Main outcome measures were frequency and severity of depression in individuals with PMS and PMDD and their clinical and sociodemographic correlation. The age range of the sample was 18-37 years. Some PMS symptoms were observed in 67%; diagnosis of PMDD in 10%; depressive symptoms in 28% of the sample. 46.4% of those with depressive symptoms had major depression. The diagnosis of major depression was significantly associated with the severity of PMS symptoms as well as the presence of PMDD. Conclusion: Premenstrual syndrome is present in a substantial proportion of young females. Concurrent depression is increased by the severity of PMS symptoms and the presence of PMDD. Gynecologist needs to screen such subjects for depression and refer to mental-health professional early, in routine clinical practice.

  4. Work Productivity in Rheumatoid Arthritis: Relationship with Clinical and Radiological Features

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    Rafael Chaparro del Moral

    2012-01-01

    Full Text Available Objective. To assess the relationship between work productivity with disease activity, functional capacity, life quality and radiological damage in patients with rheumatoid arthritis (RA. Methods. The study included consecutive employed patients with RA (ACR'87, aged over 18. Demographic, disease-related, and work-related variables were determined. The reduction of work productivity was assessed by WPAI-RA. Results. 90 patients were evaluated, 71% women. Age average is 50 years old, DAS28 4, and RAQoL 12. Median SENS is 18 and HAQ-A 0.87. Mean absenteeism was of 14%, presenting an average of 6.30 work hours wasted weekly. The reduction in performance at work or assistance was of 38.4% and the waste of productivity was of 45%. Assistance correlated with DAS28 (r = 0.446; P 18 showed lower work productivity than those with SENS < 18 (50 versus 34; P=0.04. In multiple regression analysis, variables associated with reduction of total work productivity were HAQ-A and RAQoL. Conclusion. RA patients with higher disease severity showed higher work productivity compromise.

  5. Work productivity in rheumatoid arthritis: relationship with clinical and radiological features.

    Science.gov (United States)

    Chaparro Del Moral, Rafael; Rillo, Oscar Luis; Casalla, Luciana; Morón, Carolina Bru; Citera, Gustavo; Cocco, José A Maldonado; Correa, María de Los Ángeles; Buschiazzo, Emilio; Tamborenea, Natalia; Mysler, Eduardo; Tate, Guillermo; Baños, Andrea; Herscovich, Natalia

    2012-01-01

    Objective. To assess the relationship between work productivity with disease activity, functional capacity, life quality and radiological damage in patients with rheumatoid arthritis (RA). Methods. The study included consecutive employed patients with RA (ACR'87), aged over 18. Demographic, disease-related, and work-related variables were determined. The reduction of work productivity was assessed by WPAI-RA. Results. 90 patients were evaluated, 71% women. Age average is 50 years old, DAS28 4, and RAQoL 12. Median SENS is 18 and HAQ-A 0.87. Mean absenteeism was of 14%, presenting an average of 6.30 work hours wasted weekly. The reduction in performance at work or assistance was of 38.4% and the waste of productivity was of 45%. Assistance correlated with DAS28 (r = 0.446; P productivity was noticed in higher levels of activity and functional disability. Patients with SENS > 18 showed lower work productivity than those with SENS productivity were HAQ-A and RAQoL. Conclusion. RA patients with higher disease severity showed higher work productivity compromise.

  6. Clinical presentation and early care relationships in 'poor-me' and 'bad-me' paranoia.

    Science.gov (United States)

    Morris, Emma; Milner, Philip; Trower, Peter; Peters, Emmanuelle

    2011-06-01

    OBJECTIVE. To test the proposal that 'poor-me' (PM) and 'bad-me' (BM) paranoia can be differentiated in terms of (1) current emotional experience and presence of grandiose delusions and (2) early caregiving and threats to self-construction. METHOD. Participants experiencing persecutory delusions were separated into PM (N= 21) and BM (N= 15) groups on the basis of perceived deservedness of the persecution. The groups were compared on measures examining grandiose delusions, shame and depression, parental care, and threats of alienation and insecurity. RESULTS. As predicted, BM patients scored higher on shame and depression, and lower on grandiose delusions, than PM patients. BM patients reported higher levels of parental overprotection, but PM patients were not characterized by neglect, and the groups did not differ in type of threat to self-construction. Conclusion. The two paranoia types were differentiated on symptomatic and emotional presentation, but predicted differences in early relationships and self-construction were not fully supported.

  7. Case-control approach application for finding a relationship between candidate genes and clinical mastitis in Holstein dairy cattle.

    Science.gov (United States)

    Bagheri, Masoumeh; Moradi-Sharhrbabak, M; Miraie-Ashtiani, R; Safdari-Shahroudi, M; Abdollahi-Arpanahi, R

    2016-02-01

    Mastitis is a major source of economic loss in dairy herds. The objective of this research was to evaluate the association between genotypes within SLC11A1 and CXCR1 candidate genes and clinical mastitis in Holstein dairy cattle using the selective genotyping method. The data set contained clinical mastitis records of 3,823 Holstein cows from two Holstein dairy herds located in two different regions in Iran. Data included the number of cases of clinical mastitis per lactation. Selective genotyping was based on extreme values for clinical mastitis residuals (CMR) from mixed model analyses. Two extreme groups consisting of 135 cows were formed (as cases and controls), and genotyped for the two candidate genes, namely, SLC11A1 and CXCR1, using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), respectively. Associations between single nucleotide polymorphism (SNP) genotypes with CMR and breeding values for milk and protein yield were carried out by applying logistic regression analyses, i.e. estimating the probability of the heterogeneous genotype in the dependency of values for CMR and breeding values (BVs). The sequencing results revealed a novel mutation in 1139 bp of exon 11 of the SLC11A1 gene and this SNP had a significant association with CMR (P G and these genotypes had significant relationships with CMR. Overall, the results showed that SLC11A1 and CXCR1 are valuable candidate genes for the improvement of mastitis resistance as well as production traits in dairy cattle populations.

  8. New experimental and clinical data on the relationship between magnesium and sport.

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    Rayssiguier, Y; Guezennec, C Y; Durlach, J

    1990-06-01

    commonly observed in humans. Clinical symptomatology, both in athletes and in other patients, is dominated by the symptomatology of neuromuscular hyperexcitability. Medical authorities in sport have enforced obligatory tests for latent tetany in athletes, with ionic assessment. The effects of the correction of magnesium deficiency are judged from clinical signs, Chvosteck sign, electromyogram and echocardiogram findings and plasma Mg, erythrocyte and urine analysis. These may also be complemented by cardiac and respiratory investigations after exercise. The positive effects (analysis after a minimum period of one month) of a simple oral supplement administered in physiological doses (5 mg/kg body weight/day) provides evidence for the existence of a deficiency.(ABSTRACT TRUNCATED AT 400 WORDS)

  9. Relationship between clinical factors and severity of esophageal candidiasis according to Kodsi's classification.

    Science.gov (United States)

    Asayama, N; Nagata, N; Shimbo, T; Nishimura, S; Igari, T; Akiyama, J; Ohmagari, N; Hamada, Y; Nishijima, T; Yazaki, H; Teruya, K; Oka, S; Uemura, N

    2014-04-01

    Severe Candida esophagitis (CE) may lead to development of strictures, hemorrhage, esophagotracheal fistula, and a consequent decrease in quality of life. Although the severity of CE has been classified based on macroscopic findings on endoscopy, the clinical significance remains unknown. The aim of the study was to elucidate the predictive clinical factors for endoscopic severity of CE. Patients who underwent upper endoscopy and answered questionnaires were prospectively enrolled. Smoking, alcohol, human immunodeficiency virus (HIV) infection, diabetes mellitus, chronic renal failure, liver cirrhosis, systemic steroids use, proton pump inhibitor use, H2 blocker use, and gastrointestinal (GI) symptoms were assessed on the same day of endoscopy. GI symptoms including epigastric pain, heartburn, reflux, hunger cramps, nausea, dysphagia, and odynophagia were assessed on a 7-point Likert scale. Endoscopic severity was classified as mild (Kodsi's grade I/II) or severe (grade III/IV). Of 1855 patients, 71 (3.8%) were diagnosed with CE (mild, n = 48; severe, n = 23). In the CE patients, 50.0% (24/48) in the mild group and 23.1% (6/23) in the severe group did not have any GI symptoms. In HIV-infected patients (n = 17), a significant correlation was found between endoscopic severity and declining CD4 cell count (Spearman's rho = -0.90; P < 0.01). Multivariate analysis revealed that GI symptoms (odds ratio [OR], 3.32) and HIV infection (OR, 3.81) were independently associated with severe CE. Patients in the severe group experienced more epigastric pain (P = 0.02), reflux symptoms (P = 0.04), dysphagia (P = 0.05), and odynophagia (P < 0.01) than those in the mild group. Of the GI symptoms, odynophagia was independently associated with severe CE (OR 9.62, P = 0.02). In conclusion, the prevalence of CE in adults who underwent endoscopy was 3.8%. Silent CE was found in both mild and severe cases. Endoscopic severity was associated with

  10. Nicotine dependence in the mental disorders, relationship with clinical indicators, and the meaning for the user

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    Renata Marques de Oliveira

    2014-08-01

    Full Text Available OBJECTIVE: to identify the degree of nicotine dependence among patients with schizophrenia and other mental disorders hospitalized in a general hospital, correlating these indices with clinical indicators and the meaning for the user.METHOD: the study was performed in the psychiatric unit of a general hospital, interviewing 270 patients with mental disorders using a questionnaire and the application of the Fagerstrom test. A descriptive statistical analysis of the data and thematic analysis of the content were performed.RESULTS: among the 270 patients with mental disorders, 35.6% were smokers; of whom, 53.2% presented high or very high nicotine dependence. Of the 96 smokers, 32 (33.3% were schizophrenic, among whom, 59.4% presented high or very high dependence. Higher levels of dependence were also found among the 59 elderly people (61.5% and 60 subjects with somatic comorbidities (62.5%. Meanings of smoking for the subjects: helps to forget problems and face daily conflicts; alleviates side effects of the medications; self-control; distraction; part of life.CONCLUSION: more intense tobacco dependence among schizophrenic patients is justified due to it helping them to cope with the difficulties of the disease. Nurses occupy a strategic position in the care.

  11. Mean Platelet Volume and Arterial Stiffness – Clinical Relationship and Common Genetic Variability

    Science.gov (United States)

    Panova-Noeva, Marina; Arnold, Natalie; Hermanns, M. Iris; Prochaska, Jürgen H.; Schulz, Andreas; Spronk, Henri M.; Binder, Harald; Pfeiffer, Norbert; Beutel, Manfred; Blankenberg, Stefan; Zeller, Tanja; Lotz, Johannes; Münzel, Thomas; Lackner, Karl J.; ten Cate, Hugo; Wild, Philipp S.

    2017-01-01

    Vessel wall stiffening is an important clinical parameter, but it is unknown whether platelets, key elements in the pathogenesis of arterial thrombosis, are associated with arterial stiffness. The present studies sought to determine whether mean platelet volume (MPV), a potential marker of platelet activation, is linked to vascular elasticity as assessed by the augmentation index (AIx), in 15,010 individuals from the population-based Gutenberg Health Study. Multivariable analysis showed that MPV in both males (β 0.776; 95thCI [0.250;1.16]; p = 0.0024) and females (β 0.881[0.328;1.43]; p = 0.0018) is strongly associated with AIx. Individuals with MPV and AIx above the sex-specific medians had worse survival. Association analysis between MPV-related genetic variants and arterial stiffness identified four genetic variants in males and one in females related with AIx. Cox regression analysis for mortality identified one of these joint genetic variants close to ring finger protein 145 gene (RNF145, rs10076782) linked with increased mortality (hazard ratio 2.02; 95thCI [1.35;3.02]; p = 0.00061). Thus, these population-based data demonstrate a close relation between platelet volume as a potential marker of platelet activation and arterial stiffness in both sexes. Further research is warranted to further elucidate the mechanisms underlying larger platelets‘ role in arterial stiffening including the role of shared common genetics. PMID:28059166

  12. The relationship between organizational culture and implementation of clinical practice guidelines: a narrative review.

    Science.gov (United States)

    Dodek, Peter; Cahill, Naomi E; Heyland, Daren K

    2010-01-01

    The context in which critical care providers work has been shown to be associated with adherence to recommendations of clinical practice guidelines (CPGs). Consideration of contextual factors such as organizational culture may therefore be important when implementing guidelines. Organizational culture has been defined simply as "how things are around here" and encompasses leadership, communication, teamwork, conflict resolution, and other domains. This narrative review highlights the results of recent quantitative and qualitative studies, including studies on adherence to nutrition guidelines in the critical care setting, which demonstrate that elements of organizational culture, such as leadership support, interprofessional collaboration, and shared beliefs about the utility of guidelines, influence adherence to guideline recommendations. Outside nutrition therapy, there is emerging evidence that strategies focusing on organizational change (eg, revision of professional roles, interdisciplinary teams, integrated care delivery, computer systems, and continuous quality improvement) can favorably influence professional performance and patient outcomes. Consequently, future interventions aimed at implementing nutrition guidelines should aim to measure and take into account organizational culture, in addition to considering the characteristics of the patient, provider, and guideline. Further high quality, multimethod studies are required to improve our understanding of how culture influences guideline implementation, and which organizational change strategies might be most effective in optimizing nutrition therapy.

  13. A clinical study of the relationship between crowding of teeth, plaque and gingival condition.

    Science.gov (United States)

    Ingervall, B; Jacobsson, U; Nyman, S

    1977-08-01

    A clinical trial was undertaken to assess whether crowded teeth were more likely to accumulate plaque and develop gingivitis than non-crowded teeth. A tooth was considered crowded if it was displaced by 2 mm and/or rotated 15 degrees or more from the normal position in the arch. The material consisted of 50 dental students aged 21 to 32 years. An initial examination comprised assessment of Plaque Index, Gingival Index and pocket depths. After this examination the subjects refrained from using interdental cleaning aids but continued with their normal toothbrushing for 40 days. After re-examination they were instructed in the effective use of dental floss. A final examination was carried out after 140 days. At the start of the trial no difference was found in regard to the Plaque Index between crowded and non-crowded teeth. The Gingival Index for growded front teeth, but not for crowded premolars, was somewhat higher than for the corresponding controls. The cessation of interdental cleaning resulted in a similar increase in plaque accumulation and gingival inflammation in both non-crowded and crowded teeth. The use of dental floss for approximal tooth cleaning resulted in a similar decrease in the Plaque- and Gingival Indices for both types of teeth. The results demonstrate that in a group of young adults, crowding of teeth (1) did not favour plaque accumulation on approximal tooth surfaces and (2) influenced the degree of gingival inflammation only to a minor extent.

  14. Quality of life in acne vulgaris: Relationship to clinical severity and demographic data

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    Aayush Gupta

    2016-01-01

    Full Text Available Background: Acne vulgaris is known to impair many aspects of quality of life. However, the correlation of this impairment with clinical severity remains equivocal despite various school, community and hospital-based studies. Aim: A hospital-based study was undertaken to measure the impairment of quality of life of patients of acne vulgaris and correlate it with the severity of lesions. Methods: This was a cross-sectional, questionnaire-based study in a cohort of 100 patients of acne vulgaris attending the outpatient department of our referral hospital. A physician measured the severity of lesions using the global acne grading system, and patients assessed quality of life by completing a questionnaire (Cardiff acne disability index. A correlation of these two was done; some additional correlations were brought out through demographic data collected from the patients. Results: There was no correlation between the severity of acne vulgaris and an impaired quality of life. Patients who consumed alcohol and/or smoked cigarettes were found to have an impaired quality of life. While the severity of acne progressively lessened in older patients, the impact on quality of life increased. Limitations: The sample size was small and there was a lack of guaranteed reliability on the self-reported quality of life. Conclusion: The severity of acne vulgaris does not correlate with impairment in quality of life.

  15. RELATIONSHIP BETWEEN PSYCHOPATHOLOGY & SOCIO-DEMOGRAPHIC AND CLINICAL VARIABLES IN COPD AND BRONCHIAL ASTHMA: A COMPARATIVE STUDY

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    Mayank

    2014-11-01

    Full Text Available This is a cross sectional comparative case control study assessing the Relationship between psychopathology and socio demographic and clinical variables in chronic obstructive pulmonary disease (COPD and Bronchial Asthma in comparison to healthy individuals. The investigation reveals that there is psychopathology in all the three groups. The psychopathology is significantly more in patients with COPD. Psychopathology in COPD patients is related to age, duration, severity of illness and steroid medication. It is found that psychopathology in bronchial asthma patients are more than those of healthy controls but there is no significant difference. The psychopathology is significantly related to relate to age, marital status, occupational status, and smoking. Duration severity of illness and steroid medication.

  16. Phenotypic Variation Is Almost Entirely Independent of the Host-Pathogen Relationship in Clinical Isolates of S. aureus.

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    Adrian D Land

    Full Text Available A key feature of Staphylococcus aureus biology is its ability to switch from an apparently benign colonizer of ~30% of the population to a cutaneous pathogen, to a deadly invasive pathogen. Little is known about the mechanisms driving this transition or the propensity of different S. aureus strains to engender different types of host-pathogen interactions. At the same time, significant weight has been given to the role of specific in vitro phenotypes in S. aureus virulence. Biofilm formation, hemolysis and pigment formation have all been associated with virulence in mice.To determine if there is a correlation between in vitro phenotype and the three types of host-pathogen relationships commonly exhibited by S. aureus in the context of its natural human host, we assayed 300 clinical isolates for phenotypes implicated in virulence including hemolysis, sensitivity to autolysis, and biofilm formation. For comparative purposes, we also assayed phenotype in 9 domesticated S. aureus strains routinely used for analysis of virulence determinants in laboratory settings.Strikingly, the clinical strains exhibited significant phenotypic uniformity in each of the assays evaluated in this study. One exception was a small, but significant, correlation between an increased propensity for biofilm formation and isolation from skin and soft tissue infections (SSTIs. In contrast, we observed a high degree of phenotypic variation between common laboratory strains that exhibit virulence in mouse models. These data suggest the existence of significant evolutionary pressure on the S. aureus genome and highlight a role for host factors as a strong determinant of the host-pathogen relationship. In addition, the high degree of variation between laboratory strains emphasizes the need for caution when applying data obtained in one lab strain to the analysis of another.

  17. Relationship of periodontal clinical parameters with bacterial composition in human dental plaque.

    Science.gov (United States)

    Fujinaka, Hidetake; Takeshita, Toru; Sato, Hirayuki; Yamamoto, Tetsuji; Nakamura, Junji; Hase, Tadashi; Yamashita, Yoshihisa

    2013-06-01

    More than 600 bacterial species have been identified in the oral cavity, but only a limited number of species show a strong association with periodontitis. The purpose of the present study was to provide a comprehensive outline of the microbiota in dental plaque related to periodontal status. Dental plaque from 90 subjects was sampled, and the subjects were clustered based on bacterial composition using the terminal restriction fragment length polymorphism of 16S rRNA genes. Here, we evaluated (1) periodontal clinical parameters between clusters; (2) the correlation of subgingival bacterial composition with supragingival bacterial composition; and (3) the association between bacterial interspecies in dental plaque using a graphical Gaussian model. Cluster 1 (C1) having high prevalence of pathogenic bacteria in subgingival plaque showed increasing values of the parameters. The values of the parameters in Cluster 2a (C2a) having high prevalence of non-pathogenic bacteria were markedly lower than those in C1. A cluster having low prevalence of non-pathogenic bacteria in supragingival plaque showed increasing values of the parameters. The bacterial patterns between subgingival plaque and supragingival plaque were significantly correlated. Chief pathogens, such as Porphyromonas gingivalis, formed a network with other pathogenic species in C1, whereas a network of non-pathogenic species, such as Rothia sp. and Lautropia sp., tended to compete with a network of pathogenic species in C2a. Periodontal status relates to non-pathogenic species as well as to pathogenic species, suggesting that the bacterial interspecies connection affects dental plaque virulence.

  18. Programmed death ligand 1 expression in hepatocellular carcinoma: Relationship With clinical and pathological features.

    Science.gov (United States)

    Calderaro, Julien; Rousseau, Benoît; Amaddeo, Giuliana; Mercey, Marion; Charpy, Cécile; Costentin, Charlotte; Luciani, Alain; Zafrani, Elie-Serge; Laurent, Alexis; Azoulay, Daniel; Lafdil, Fouad; Pawlotsky, Jean-Michel

    2016-12-01

    The prognosis of hepatocellular carcinoma (HCC) remains poor, with only one third of patients eligible for curative treatments and very limited survival benefits with the use of sorafenib, the current standard of care for advanced disease. Recently, agents targeting the programmed death ligand 1 (PD-L1)/programmed death receptor 1 (PD-1) immune checkpoint were shown to display impressive antitumor activity in various solid or hematological malignancies, including HCC. PD-L1 immunohistochemical expression is thought to represent a biomarker predictive of drug sensitivity. Here, we investigated PD-L1 expression in a series of 217 HCCs and correlated our results with clinical and histological features and immunohistochemical markers (PD-1, cytokeratin 19, glutamine synthetase, and β-catenin expression). PD-L1 expression by neoplastic cells was significantly associated with common markers of tumor aggressiveness (high serum alpha-fetoprotein levels, P = 0.038; satellite nodules, P < 0.001; macrovascular invasion, P < 0.001; microvascular invasion, P < 0.001; poor differentiation, P < 0.001) and with the progenitor subtype of HCC (cytokeratin 19 expression, P = 0.031). High PD-L1 expression by inflammatory cells from the tumor microenvironment also correlated with high serum alpha-fetoprotein levels (P < 0.001), macrovascular invasion (P = 0.001), poor differentiation (P = 0.001), high PD-1 expression (P < 0.001), and the so-called lymphoepithelioma-like histological subtype of HCC (P = 0.003).

  19. The relationship between serum trace element levels and clinical parameters in patients with fibromyalgia.

    Science.gov (United States)

    Sendur, Omer Faruk; Tastaban, Engin; Turan, Yasemin; Ulman, Cevval

    2008-09-01

    We examined the association between serum trace elements and clinical findings such as number of sensitive tender points, severity of fatigue and functional status in patients with fibromyalgia (FM). Thirty-two patients diagnosed as having FM according to the ACR 1990 criteria and 32 normal healthy controls (NHC) were included in this study. The demographic data, disease duration, number of tender points and accompanying symptoms (fatigue, sleep disorders, headache, paresthesia, irritable bowel syndrome, sicca symptoms, Raynaud's phenomena) of the patients were noted. Visual analog scale (10 cm) was implemented to estimate daily severity of pain and fatigue. Fibromyalgia impact questionnaire was used for functional assessment. Serum selenium (microg/dL) and serum zinc (microg/dL) levels were measured by atomic absorption spectrometer. Serum magnesium (mmol/L) level was measured by the original kits of Abbott Aeroset auto-analyzer. The mean age of patients in FM group and NHC were calculated as 42.9 (SD = 7.7) years and 41.3 (SD = 9.7) years, respectively. Serum levels of zinc (P = 0.001) and magnesium (P = 0.002) were significantly decreased by FM groups, whereas there was no considerable difference with selenium levels of both groups (P > 0.05). Association between serum zinc level and number of tender points (P = 0.008) and that between fatigue and magnesium level (P = 0.003) was found as meaningful. According to the results of this study, it was asserted that serum magnesium and zinc levels may play an important role in the pathophysiology of FM.

  20. Relationship Between Blood Fibrinogen Concentration and Pathological Features of Cancer Patients: A 139-case Clinical Study

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    Da-Yong Lu

    2007-01-01

    Full Text Available Angiogenesis and coagulation are among the most consistent host responses to the presence of a malignant tissue. Pathological angiogenesis and coagulation are often occurred in patients with solid tumors, especially in the occurrence of neoplasm metastasis and as targets for anti-metastatic drugs such as antiangiogenesis agents, coagulation-mediated agents and anticancer drugs. Since fibrinogen (Fib is the most abundant and key haemostatic protein taking part in angiogenesis and coagulation, its biological and pathophysiological roles in cancer patients are intriguing. To continue foundational and translational research on Fib-related cancer pathogenesis, a phase II survey of 139 patients was carried out at the Central Hospital of Jing-An district and Shanghai University, Shanghai, China. The mean BFC of the cancer patients in this survey was overall about 35-50% greater than that in the normal population. This study showed that the mean BFC was higher in patients with long-distance metastases (N1M1 patients than in patients with no sign of long-distance metastases (N0M0 patients. Mean BFCs were 4.42 g/L (n= 21 in patients with lung cancer, 4.36 g/L, and in patients with hepatic cancer (n=5, and 4.63 g/L in patients with stomach cancer (n=8, all higher than the average value of the cancer patients overall (4.16 g/L. However, patients with bowel and colon cancers 3.79 g/L (n=16 showed lower than them. BFC levels increased with increasing cancer duration (latency > 1 year. There was a slight decrease in BFC after one or two treatment cycles, but a more marked decrease after surgery. We propose that the BFC level in cancer patients may be influenced by and related to many aspects of cancer progression such as metastatic conditions, tumor origins, patient’s pathological stage and disease latency. As an important first-hand pathologic-therapeutics relationship study, it provides evidence for the potentiality of a new approach of Fib-targeted as

  1. Clinical efficacy of emollients in atopic dermatitis patients – relationship with the skin microbiota modification

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    Seité S

    2017-01-01

    Full Text Available Sophie Seité,1 Hana Zelenkova,2 Richard Martin3 1La Roche-Posay Dermatological Laboratories, Asnières, France; 2DOST, Private Clinic of Dermatovenereology, Svidnik, Slovakia; 3L’Oréal Research and Innovation, Tours, France Background: We speculated that an emollient supplemented with a biomass of nonpathogenic bacteria such as Vitreoscilla filiformis (Vf, grown in a medium containing thermal spring water (LRP-TSW; (LRP-Vitreoscilla filiformis biomass [LRP-VFB], could have a beneficial effect for patients with atopic dermatitis (AD. Patients and methods: This double-blind, randomized, comparative study was conducted with 60 patients with moderate AD. Before starting the study, participants were pretreated for 15 days with drug therapy to improve their SCORing Atopic Dermatitis (SCORAD by at least 25%. On Day 1, the eligible patients were randomized to either the emollient containing LRP-VFB associated with mannose (Product A or another emollient (product B and were treated twice daily for 1 month. Recurrence of flare-ups and microbial communities were characterized from swabs taken at Day 1 and Day 28, under axenic conditions, from affected (AF and proximal unaffected (UAF skin areas. Results: At Day 1, the average SCORAD of each group and the microbial communities of AF and UAF areas for each participant were similar. One month after the end of the therapeutic treatment (Day 28, the average evolution of SCORAD at Day 28 compared to Day 1 of patients treated with product A was significantly lower than that of the patients treated with product B. A significantly increased level of Xanthomonas genus was noticed in the group treated with product A (versus product B. On the other hand, the level of Staphylococcus genus increased between Day 1 and Day 28 in the group treated with product B, but not in the group treated with product A. Interestingly, these differences were more pronounced for patients in relapse, and the associated SCORAD

  2. Folie à Deux – A Clinical Case of Folie Imposée in a Mother/Child Relationship

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    Marta Nascimento

    2013-11-01

    Full Text Available Background: Even though the origin of the concept of shared delusion is not consensual, the term folie a deux was introduced in 1877 by two french researchers – Lasègue and Falret. According to the original concept, a person (inductor, cognitively dominant, develops a delusional idea that progressively imposes to a second person (induced, with whom he keeps a close relationship. The four psychopathologic subtypes known – folie imposée, folie simultanée, folie communiquée and folie induite, were described in the final of the XIX century, but its classification and conceptualization was assigned to the american researcher Gralnick (1942. Aim, materials and methods: It is intended to highlight some clinical aspects of the shared delusion disorder, its epidemiological and psycopathogenic characterization and therapeutical approach. In order to achieve it, the authors presented a clinical case report and respective non systematic literature review. Results: It is a case of shared delusion of the type folie imposée in a pair mother/son. The inductor (son suffers from bipolar disorder and asperger syndrome and shared with his mother (induced and carer a persecutory delusion. Conclusions: It is highlighted the importance of a social isolation context and close contact between both members in the genesis of the disease; it is discussed the subject of the cognitive dominance between the inductor and the induced and the implications of the separation of the pair mother/son, as primary therapeutic action.

  3. Folie à Deux – A Clinical Case of Folie Imposée in a Mother/Child Relationship

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    Marta Nascimento

    2012-12-01

    Full Text Available Background: Even though the origin of the concept of shared delusion is not consensual, the term folie a deux was introduced in 1877 by two french researchers – Lasègue and Falret. According to the original concept, a person (inductor, cognitively dominant, develops a delusional idea that progressively imposes to a second person (induced, with whom he keeps a close relationship. The four psychopathologic subtypes known – folie imposée, folie simultanée, folie communiquée and folie induite, were described in the final of the XIX century, but its classification and conceptualization was assigned to the american researcher Gralnick (1942. Aim, materials and methods: It is intended to highlight some clinical aspects of the shared delusion disorder, its epidemiological and psycopathogenic characterization and therapeutical approach. In order to achieve it, the authors presented a clinical case report and respective non systematic literature review. Results: It is a case of shared delusion of the type folie imposée in a pair mother/son. The inductor (son suffers from bipolar disorder and asperger syndrome and shared with his mother (induced and carer a persecutory delusion. Conclusions: It is highlighted the importance of a social isolation context and close contact between both members in the genesis of the disease; it is discussed the subject of the cognitive dominance between the inductor and the induced and the implications of the separation of the pair mother/son, as primary therapeutic action.

  4. The Relationship of Osteoporosis Risk Factors with Bone Mineral Density in Patients Admitted Our Outpatient Clinic in Trabzon

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    Münevver Serdaroğlu Beyazal

    2016-04-01

    Full Text Available Objective: Our aim was to identify the relationship of osteoporosis (OP risk factors with bone mineral density (BMD in patients admitted our outpatient clinic in Trabzon. Materials and Methods: Two hundred one patients with OP or osteopenia were included in this study. Sociodemographic characteristics of the patients were recorded and a standardized interview was employed by the researcher physician. BMD values were measured by dual energy X-ray absorptiometry at lumbar spine and femoral neck. Results: The mean age of the patients was 61.47±10.57 years (182 females/19 males. One hundred fifteen patients (57.2% were osteoporotic and 86 (42.8% were osteopenic. A significant negative correlation was found between age and femoral neck T scores. The number of pregnancies showed a significant negative correlation with lumbar T scores. Body mass index and daily tea consumption showed a negligible positive correlation with femoral neck T scores. No association was found between age at menarche, age at menopause, total lactation duration, daily calcium intake and T scores of lumbar spine and femoral neck. Conclusions: Identification of regional OP risk factors may be useful for the OP risk management of patients in clinical practice.

  5. The relationship between carers' report of autistic traits and clinical diagnoses of autism spectrum disorders in adults with intellectual disability.

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    Bhaumik, Sabyasachi; Tyrer, Freya; Barrett, Mary; Tin, Nyunt; McGrother, Catherine W; Kiani, Reza

    2010-01-01

    It is often difficult to determine the triad of impairments and whether autistic features are the consequence of intellectual impairment or autism spectrum disorders in people with intellectual disability (ID). The aim of the current study was to investigate the relationship between carer-reported autistic traits and independent diagnoses of autism spectrum disorders (ASD). Data were collected on carers' subjective report of autistic traits and clinical diagnoses of ASD. Of 1145 adults with ID identified, 220 (19%) individuals had a diagnosis of ASD, and 778 (68%) individuals had at least one autistic trait. Optimal sensitivity and specificity were achieved with two or more autistic traits (sensitivity 63%; specificity 79%) and the positive predictive value increased substantially as the number of autistic traits increased. However, a significant proportion of individuals with ID who did not have a diagnosis of ASD also displayed autistic traits. Our findings suggest that in the absence of other measures, the presence of autistic traits can serve as a useful proxy measure for ASD in research (and/or clinical settings). However, although information on autistic traits may help healthcare practitioners to identify people with possible ASD, it cannot be used alone to make a formal diagnosis.

  6. Relationship between linguistic functions and cognitive functions in a clinical study of Chinese patients with post-stroke aphasia

    Institute of Scientific and Technical Information of China (English)

    YU Zeng-zhi; JIANG Shu-jun; BI Sheng; LI Jun; LEI Di; SUN Li-ling

    2013-01-01

    Background There has been a long debate among scholars surrounding the relationship between language and cognition.The worldwide study of aphasia is actively exploring the function of language from cognitive point of view.This study aimed to investigate the relationship between linguistic functions and cognitive functions in a clinical study of Chinese patients with post-stroke aphasia.Methods Cognitive functions of 63 Chinese patients with aphasia following a stroke were assessed with the Chinese version of the second edition of Loewenstein Occupational Therapy Cognitive Assessment (LOTCA) battery and their linguistic functions were tested with the Western Aphasia Battery (WAB) Scale,respectively.The correlation between the results observed on the LOTCA battery and those on the WAB was analyzed.Aphasia quotient,performance quotient,cortical quotient,and linguistic function of the patients were compared.Then,each language function was analyzed by way of dependent adopt multiple regression analysis.Results The total score of 63 patients as shown on the LOTCA battery was significantly correlated with the aphasia quotient,performance quotient,and cortical quotient observed on the WAB Scale (P <0.05,P <0.01).However,the correlation between visuomotor organization under LOTCA and repeat under WAB was not significant (P >0.05).The attention of LOTCA and WAB's spontaneous speech,repeat,naming,and aphasia quotient was not relevant either (P>0.05).In addition,correlations between the results observed on the LOTCA battery and the WAB were significant (P<0.05,P <0.01).Among the significant variables finally entered into the standardized canonical discriminant functions,main factors affected the aphasia.Multiple regression analysis showed that orientation,spatial perception,and visual perception had a notable influence on aphasia quotient and naming.Orientation and thinking operation was found to have a notable influence on spontaneous speech.Spatial perception and

  7. Interfaces between electronic medical record (EMR/EHR) technology and people in American medicine: insight. imagination, and relationships in clinical practice.

    Science.gov (United States)

    Stein, Howard F

    2012-08-01

    This paper explores the contexts and relationships in which EMR/EHR technology is used in healthcare settings. It approaches the EMR/EHR as an issue in clinical ethics. The author recognizes the immense contribution that healthcare informatics makes to coordinating and integrating medical care at the level of individual physician, nurse, and institutions. At the same time the author raises a cautionary note about some unrecognized dimensions of the use and experience of the EMR/EHR. The author argues that the EMR/EHR can consciously and unconsciously become an instrument of assembly line-like physician "productivity" and "production reports" that depersonalize patient and physician alike. Construed this way, the EMR/EHR can narrow the clinician's imagination, relationships, clinical decision-making, and documentation into oversimplified, and potentially distorting, clinical narratives and categories such as fit into CPT, ICD-9, DRG, DSM-IV and other codes, EBM protocols, and clinical algorithms. By contrast, the author uses a vignette and one of his own clinical poems to illustrate the rich weave of relationship and meaning that are foreground rather than background in clinical assessment, decision-making, treatment, outcome, and satisfaction. The author concludes with a call to imaginatively use the EMR/EHR as an instrument of physician-patient communication, and to include in it and make available vital narrative data (evidence) about patient, family, culture, occupation, socioeconomic status, physician, disease, and their relationships.

  8. Clinical impact of the temporal relationship between depression and type 2 diabetes: the Fremantle diabetes study phase II.

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    David G Bruce

    Full Text Available BACKGROUND: The clinical features of type 2 diabetes may differ depending on whether first depression episode precedes or follows the diagnosis of diabetes. METHODS: Type 2 patients from the observational community-based Fremantle Diabetes Study Phase II underwent assessment of lifetime depression using the Brief Lifetime Depression Scale (developed and validated for this study supplemented by information on current depression symptoms (Patient Health Questionnaire, 9-item version and use of antidepressants. Patients were categorized as never depressed (Group 1, having had depression before diabetes diagnosis (Group 2, diagnosed with depression and diabetes within 2 years of each other (Group 3 and having depression after diabetes diagnosis (Group 4. RESULTS: Of 1391 patients, 20.8% were assigned to Group 2, 6.0% to Group 3 and 14.5% to Group 4. In Group 2, depression occurred a median 15.6 years before diabetes onset at age 37.2±14.7 years. These patients had similar clinical characteristics to never depressed patients except for reduced self-care behaviours and having more symptomatic peripheral arterial disease. In Group 4, depression occurred a median 9.9 years after diabetes onset at age 59.8±13.0 years. These patients had long duration diabetes, poor glycaemic control, more intensive management and more diabetic complications. Group 4 patients had more current depression than Group 2 but were less likely to be receiving antidepressants. CONCLUSIONS/INTERPRETATION: The clinical features of depression and type 2 diabetes are heterogeneous depending on their temporal relationship. There may be corresponding differences in the pathogenesis of depression in diabetes that have implications for diagnosis and management.

  9. Interhemispheric functional connectivity and its relationships with clinical characteristics in major depressive disorder: a resting state fMRI study.

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    Li Wang

    Full Text Available BACKGROUND: Abnormalities in large-scale, structural and functional brain connectivity have been increasingly reported in patients with major depressive disorder (MDD. However, MDD-related alterations in functional interaction between the cerebral hemispheres are still not well understood. Resting state fMRI, which reveals spontaneous neural fluctuations in blood oxygen level dependent signals, provides a means to detect interhemispheric functional coherence. We examined the resting state functional connectivity (RSFC between the two hemispheres and its relationships with clinical characteristics in MDD patients using a recently proposed measurement named "voxel-mirrored homotopic connectivity (VMHC". METHODOLOGY/PRINCIPAL FINDINGS: We compared the interhemispheric RSFC, computed using the VMHC approach, of seventeen first-episode drug-naive patients with MDD and seventeen healthy controls. Compared to the controls, MDD patients showed significant VMHC decreases in the medial orbitofrontal gyrus, parahippocampal gyrus, fusiform gyrus, and occipital regions including the middle occipital gyrus and cuneus. In MDD patients, a negative correlation was found between VMHC of the fusiform gyrus and illness duration. Moreover, there were several regions whose VMHC showed significant negative correlations with the severity of cognitive disturbance, including the prefrontal regions, such as middle and inferior frontal gyri, and two regions in the cereballar crus. CONCLUSIONS/SIGNIFICANCE: These findings suggest that the functional coordination between homotopic brain regions is impaired in MDD patients, thereby providing new evidence supporting the interhemispheric connectivity deficits of MDD. The significant correlations between the VMHC and clinical characteristics in MDD patients suggest potential clinical implication of VMHC measures for MDD. Interhemispheric RSFC may serve as a useful screening method for evaluating MDD where neural connectivity is

  10. A Global View of the Relationships between the Main Behavioural and Clinical Cardiovascular Risk Factors in the GAZEL Prospective Cohort

    Science.gov (United States)

    Meneton, Pierre; Lemogne, Cédric; Herquelot, Eléonore; Bonenfant, Sébastien; Larson, Martin G.; Vasan, Ramachandran S.; Ménard, Joël; Goldberg, Marcel; Zins, Marie

    2016-01-01

    Although it has been recognized for a long time that the predisposition to cardiovascular diseases (CVD) is determined by many risk factors and despite the common use of algorithms incorporating several of these factors to predict the overall risk, there has yet been no global description of the complex way in which CVD risk factors interact with each other. This is the aim of the present study which investigated all existing relationships between the main CVD risk factors in a well-characterized occupational cohort. Prospective associations between 12 behavioural and clinical risk factors (gender, age, parental history of CVD, non-moderate alcohol consumption, smoking, physical inactivity, obesity, hypertension, dyslipidemia, diabetes, sleep disorder, depression) were systematically tested using Cox regression in 10,736 middle-aged individuals free of CVD at baseline and followed over 20 years. In addition to independently predicting CVD risk (HRs from 1.18 to 1.97 in multivariable models), these factors form a vast network of associations where each factor predicts, and/or is predicted by, several other factors (n = 47 with p<0.05, n = 37 with p<0.01, n = 28 with p<0.001, n = 22 with p<0.0001). Both the number of factors associated with a given factor (1 to 9) and the strength of the associations (HRs from 1.10 to 6.12 in multivariable models) are very variable, suggesting that all the factors do not have the same influence within this network. These results show that there is a remarkably extensive network of relationships between the main CVD risk factors which may have not been sufficiently taken into account, notably in preventive strategies aiming to lower CVD risk. PMID:27598908

  11. Absence of a relationship between immunophenotypic and colony enumeration analysis of endothelial progenitor cells in clinical haematopoietic cell sources

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    Turner Marc L

    2007-07-01

    Full Text Available Abstract Background The discovery of adult endothelial progenitor cells (EPC offers potential for vascular regenerative therapies. The expression of CD34 and VEGFR2 by EPC indicates a close relationship with haematopoietic progenitor cells (HPC, and HPC-rich sources have been used to treat cardiac and limb ischaemias with apparent clinical benefit. However, the laboratory characterisation of the vasculogenic capability of potential or actual therapeutic cell autograft sources is uncertain since the description of EPC remains elusive. Various definitions of EPC based on phenotype and more recently on colony formation (CFU-EPC have been proposed. Methods We determined EPC as defined by proposed phenotype definitions (flow cytometry and by CFU-EPC in HPC-rich sources: bone marrow (BM; cord blood (CB; and G-CSF-mobilised peripheral blood (mPB, and in HPC-poor normal peripheral blood (nPB. Results As expected, the highest numbers of cells expressing the HPC markers CD34 or CD133 were found in mPB and least in nPB. The proportions of CD34+ cells co-expressing CD133 is of the order mPB>CB>BM≈nPB. CD34+ cells co-expressing VEGFR2 were also most frequent in mPB. In contrast, CFU-EPC were virtually absent in mPB and were most readily detected in nPB, the source lowest in HPC. Conclusion HPC sources differ in their content of putative EPC. Normal peripheral blood, poor in HPC and in HPC-related phenotypically defined EPC, is the richest source of CFU-EPC, suggesting no direct relationship between the proposed EPC immunophenotypes and CFU-EPC potential. It is not apparent whether either of these EPC measurements, or any, is an appropriate indicator of the therapeutic vasculogenic potential of autologous HSC sources.

  12. A Global View of the Relationships between the Main Behavioural and Clinical Cardiovascular Risk Factors in the GAZEL Prospective Cohort.

    Science.gov (United States)

    Meneton, Pierre; Lemogne, Cédric; Herquelot, Eléonore; Bonenfant, Sébastien; Larson, Martin G; Vasan, Ramachandran S; Ménard, Joël; Goldberg, Marcel; Zins, Marie

    2016-01-01

    Although it has been recognized for a long time that the predisposition to cardiovascular diseases (CVD) is determined by many risk factors and despite the common use of algorithms incorporating several of these factors to predict the overall risk, there has yet been no global description of the complex way in which CVD risk factors interact with each other. This is the aim of the present study which investigated all existing relationships between the main CVD risk factors in a well-characterized occupational cohort. Prospective associations between 12 behavioural and clinical risk factors (gender, age, parental history of CVD, non-moderate alcohol consumption, smoking, physical inactivity, obesity, hypertension, dyslipidemia, diabetes, sleep disorder, depression) were systematically tested using Cox regression in 10,736 middle-aged individuals free of CVD at baseline and followed over 20 years. In addition to independently predicting CVD risk (HRs from 1.18 to 1.97 in multivariable models), these factors form a vast network of associations where each factor predicts, and/or is predicted by, several other factors (n = 47 with p<0.05, n = 37 with p<0.01, n = 28 with p<0.001, n = 22 with p<0.0001). Both the number of factors associated with a given factor (1 to 9) and the strength of the associations (HRs from 1.10 to 6.12 in multivariable models) are very variable, suggesting that all the factors do not have the same influence within this network. These results show that there is a remarkably extensive network of relationships between the main CVD risk factors which may have not been sufficiently taken into account, notably in preventive strategies aiming to lower CVD risk.

  13. The Relationship between Apoptosis and the Expression of Proliferating Cell Nuclear Antigen and the Clinical Stages in Gastric Carcinoma

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The relationship between the apoptosis and the expression of proliferating cell nuclear antigen (PCNA) and the clinical stages in gastric cancers was studied. By using terminal deoxynucleotidyl transferase-mediated nick end labelling (TUNEL) technique and PCNA immunohistochemical staining, the apoptosis and the expression of PCNA in tissue of gastric carcinoma were assayed in situ, the index of apoptosis (AI), index of PCNA (PI) and the rate of AI/PI were calculated. AI and PI in gastric cancer tissues were (6.5±3.7) % and (49.8±15.9) % respectively, and the rate of AI/PI was 0.13±0.05, which were obviously different from those of normal gastric mucosa in paragastric cancer (P<0.01). With the advanced TNM stages of gastric carcinoma, the AI was decreased, PI was increased and the rate of AI/PI decreased in gastric carcinoma. There was significant difference in them between the gastric cancer tissues and normal gastric mucosa in pericarcinoma in TNM stage Ⅱ to Ⅳ (P<0.05). It was suggested that the decreased apoptotic cells and the increased proliferating cells were obviously related to the tumor genesis and tumor progression in gastric carcinoma. The AI, PI and the rate of AI/PI would become the prognostic factors in advanced gastric carcinoma.

  14. m-Chlorophenylpiperazine challenge in borderline personality disorder: relationship of neuroendocrine response, behavioral response, and clinical measures.

    Science.gov (United States)

    Stein, D J; Hollander, E; DeCaria, C M; Simeon, D; Cohen, L; Aronowitz, B

    1996-09-15

    We have previously found that a subgroup of patients with impulsive personality disorders respond to m-chlorophenylpiperazine (m-CPP) administration with a distinctive spacy/high behavioral reaction and with increased cortisol responses. In this report we analyzed the relationship between behavioral and neuroendocrine responses to m-CPP in an enlarged sample of patients with borderline personality disorder (BPD). We also assessed the association of behavioral and neuroendocrine responses with clinical symptoms and with m-CPP blood levels. We found that in BPD patients the presence of a spacy/high behavioral response was significantly associated with increased prolactin and cortisol responses to m-CPP. In BPD patients increased m-CPP levels were significantly associated with neuroendocrine hypersensitivity and with a spacy/high behavioral response, while in controls increased m-CPP levels were not significantly associated with neuroendocrine hypersensitivity but were significantly associated with dysphoric behavioral responses. Taken together with previous work on m-CPP in obsessive-compulsive disorder, these results are partially consistent with the hypothesis that compulsive and impulsive symptoms fall at opposite ends of a phenomenologic and neurobiologic spectrum.

  15. Relationship Between Bone Minerals Density and Some Characteristics of Postmenopausal Women who Were Visiting Orthopedics Clinics - Original Investigation

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    Gülendam Karadağ

    2007-12-01

    Full Text Available Aim: Frequency of osteoporosis that depending different factors in postmenopausal women is increase. So our study was done to determine the relationship between some habits of the postmenopausal women and bone mineral density. Material and Methods: The study was done as descriptive a hospital in Gaziantep between the dates 3 July - 8 August, 2006. The comprehension of the study is all patients who applied to orthopedics clinics, and sampling consists of 70 patients who wanted to join study, and postmenopausal, hadn’t taken steroid and calcitonin treatment more than last one year. Before study, informed approwal was taken from patients and institution. Data of the study were collected using questionnaire form. Density of bone minerals was grouped according to the standarts of WHO as normal (t>-1.0, osteopenic (t0.05. Conclusion: It was seen that majority of patients didn’t make sports regularly, and the risk of having osteoporosis was higher who were getting older. For this reason, it can be suggested that to prevent osteoporosis especially in postmenopausal women necessary education should be given. (From the World of Osteoporosis 2007;13:75-9

  16. Relationship between alcohol consumption and clinical manifestation of patients with fatty liver:a single-center study

    Institute of Scientific and Technical Information of China (English)

    Xiu-FangWang; MinYue

    2011-01-01

    BACKGROUND: Fatty liver is a common chronic liver disease worldwide. It is associated with an increasing morbidity in China in recent years. The aim of this study was to analyze the effect of drinking alcohol on the hemoglobin and biochemical values of patients with fatty liver. METHODS: We investigated the clinical and laboratory data of 669 patients with fatty liver. Of the 669 patients, 166 consumed alcohol more than 60 g per week for at least 2 years, and 503 did not have a history of long-term alcohol consumption. We further analyzed the relationship between alcohol consumption and clinicalcharacteristicsofthesepatients. RESULTS: The values of aspartate transaminase (AST), gamma-glutamyl transpeptidase (GGT), and hemoglobin in the long-term consumption group were significantly higher than those in the non long-term consumption group (P CONCLUSION: Alcohol consumption is associated with significantly increased values of AST, GGT, and hemoglobin in patients with fatty liver, suggesting their potential roles in hepatic steatosis.

  17. Relationship between haemagglutination-inhibiting antibody titres and clinical protection against influenza: development and application of a bayesian random-effects model

    Directory of Open Access Journals (Sweden)

    Megas Françoise

    2010-03-01

    Full Text Available Abstract Background Antibodies directed against haemagglutinin, measured by the haemagglutination inhibition (HI assay are essential to protective immunity against influenza infection. An HI titre of 1:40 is generally accepted to correspond to a 50% reduction in the risk of contracting influenza in a susceptible population, but limited attempts have been made to further quantify the association between HI titre and protective efficacy. Methods We present a model, using a meta-analytical approach, that estimates the level of clinical protection against influenza at any HI titre level. Source data were derived from a systematic literature review that identified 15 studies, representing a total of 5899 adult subjects and 1304 influenza cases with interval-censored information on HI titre. The parameters of the relationship between HI titre and clinical protection were estimated using Bayesian inference with a consideration of random effects and censorship in the available information. Results A significant and positive relationship between HI titre and clinical protection against influenza was observed in all tested models. This relationship was found to be similar irrespective of the type of viral strain (A or B and the vaccination status of the individuals. Conclusion Although limitations in the data used should not be overlooked, the relationship derived in this analysis provides a means to predict the efficacy of inactivated influenza vaccines when only immunogenicity data are available. This relationship can also be useful for comparing the efficacy of different influenza vaccines based on their immunological profile.

  18. Expression of Yes-associated protein in non-small cell lung cancer and its relationship with clinical pathological factors

    Institute of Scientific and Technical Information of China (English)

    SU Li-li; MA Wei-xia; YUAN Jian-feng; SHAO Yang; XIAO Wei; JIANG Shu-juan

    2012-01-01

    Background Yes-associated protein(YAP)plays an important role in signal transduction and gene transcription regulation in normal cells,with elevated and over-expressed YAP levels observed in various malignant tumors.The aim of this study was to investigate the expression of YAP in non-small cell lung cancer(NSCLC),and to study the possible relationship of YAP expression with the occurrence and development of NSCLC.Methods YAP expression was assessed in 40 cases of NSCLC tumor tissues by immunohistochemistry,and their protein and mRNA levels were evaluated through Western blotting and reverse transcription-polymerase chain reaction(PCR),respectively.Normal lung tissues obtained from the same patient were used as control.Statistical analysis was performed to correlate the YAP expression to clinical pathological factors,such as tumor type,stage and grade.Results YAP-positive expression was found in 28(70%)of the 40 cases of NSCLC,which included 10 cases of squamous cell carcinoma(25%),17 cases of adenocarcinoma(42.5%)and 1 case of squamous adenocarcinoma(2.5%).In the 28 YAP-positive cases,19 cases showed lymph node metastasis and were classified in TNM stage Ⅱ+Ⅲ(47.5%);the other nine cases showed no lymph node metastasis(22.5%)and were classified in the TNM stage Ⅰ.There was no relationship between YAP expression and patients'age,gender or tumor histological grades.However,YAP showed significant over expression in late period of T stage(P=0.012),TNM stage(P=0.039),and lymph node metastasis(P=0.013),respectively.Notably,YAP-positive expression was significantly higher in adenocarcinoma than that in squamous cell carcinoma(P=0.041).Conclusions Over-expression of YAP was associated with NSCLC,especially lung adenocarcinoma.The high YAP expression in late period of tumor stage and lymph node metastasis may indicate that YAP expression could be an early marker for NSCLC tumorigenesis.

  19. Preliminary findings of cortical thickness abnormalities in blast injured service members and their relationship to clinical findings.

    Science.gov (United States)

    Tate, D F; York, G E; Reid, M W; Cooper, D B; Jones, L; Robin, D A; Kennedy, J E; Lewis, J

    2014-03-01

    Though cortical abnormalities have been demonstrated in moderate and severe traumatic brain injured (TBI) patients, there have been no studies examining cortical changes following blast related mild TBI (mTBI). The purpose of this study was to determine the effects and functional relevance of blast mTBI on cortical thickness in a small cohort of carefully screened blast injured US Service Members (SM). Twelve SM with mTBI acquired through blast injury were compared to 11 demographically matched control SM without TBI. Both mTBI and control participants were active duty and had completed a combat deployment. Subjects underwent MRI examination and the T1 weighted anatomic images were processed using the FreeSurfer suite of tools. Cortical thickness maps were compared between groups and examined for relationships with time since injury (TSI). Utilizing a large database of functional imaging results (BrainMap), significant regions of interest (ROI) were used to determine the behavioral profiles most consistently associated with the specific ROI. In addition, clinical variables were examined as part of post-hoc analysis of functional relevance. Group comparisons controlling for age demonstrated several significant clusters of cortical thinning for the blast injured SM. After multiple comparisons correction (False Discovery Rate (FDR)), two left hemisphere clusters remained significant (left superior temporal (STG) and frontal (SFG) gyri). No clusters were significantly correlated with TSI after FDR correction. Behavioral analysis for the STG and SFG clusters demonstrated three significant behavioral/cognitive sub-domains, each associated with audition and language. Blast injured SMs demonstrated distinct areas of cortical thinning in the STG and SFG. These areas have been previously shown to be associated with audition and language. Post-hoc analyses of clinical records demonstrated significant abnormal audiology reports for the blast injured SM suggesting that the

  20. Semicircular canal dehiscence: Frequency and distribution on temporal bone CT and its relationship with the clinical outcomes

    Energy Technology Data Exchange (ETDEWEB)

    Elmali, Muzaffer, E-mail: muzafel@yahoo.com.tr [Department of Radiology, Ondokuz Mayis University, Faculty of Medicine, Samsun (Turkey); Polat, Ahmet Veysel, E-mail: veyselp@hotmail.com [Department of Radiology, Ondokuz Mayis University, Faculty of Medicine, Samsun (Turkey); Kucuk, Harun, E-mail: hardrmd@yahoo.com [Department of Otorhinolaryngology, Ondokuz Mayis University, Faculty of Medicine, Samsun (Turkey); Atmaca, Sinan, E-mail: sinanatmaca@yahoo.com [Department of Otorhinolaryngology, Ondokuz Mayis University, Faculty of Medicine, Samsun (Turkey); Aksoy, Ahmet, E-mail: toxocara47@hotmail.com [Department of Otorhinolaryngology, Ondokuz Mayis University, Faculty of Medicine, Samsun (Turkey)

    2013-10-01

    Purpose: In this study, we aimed to investigate the frequency of SCD and its distribution and relationship with clinical outcomes on thin-section CT of the temporal bone. Materials and methods: Digital temporal bone CT images of 850 consecutive patients (1700 temporal bone CTs, 5100 SCs) who presented with a range of complaints such as vertigo, deafness, ear pain, fullness, and discharge between January 2008 and December 2011 were re-evaluated. Axial and oblique coronal reconstruction images of the temporal bone were made with a reconstruction thickness of 0.5 mm. Additionally, superior SC was evaluated in two perpendicular planes. Results: Out of 850 patients, 70 had completely normal temporal bone CT. Ninety-three patients had at least one SCD. In the temporal bone-based evaluation, 119 (26 bilateral, 67 unilateral) of 1700 temporal bones (7%) showed dehiscence. The SC-based evaluation revealed 125 SCD (2.5%) in 5100 SCs. The total number and rates of SCD were as follows: superior 103 (82.4%), posterior 13 (10.4%), and lateral nine (7.2%). Twenty of the 93 patients with SCD (21.5%) revealed no other findings on their temporal bone CTs. We determined a significant correlation between vestibular complaints, conductive hearing loss and SCD but there was no correlation between mixed, sensorineural hearing loss and SCD. Conclusion: We determined the frequency of SCD in 11% of patients and 7% of temporal bones. With regards to the distribution, the superior SC showed the highest dehiscence rate (82.4%). We found a significant correlation between vestibular symptoms, conductive hearing loss and SCD.

  1. The relationship between baseline Organizational Readiness to Change Assessment subscale scores and implementation of hepatitis prevention services in substance use disorders treatment clinics: a case study

    Directory of Open Access Journals (Sweden)

    Hagedorn Hildi J

    2010-06-01

    Full Text Available Abstract Background The Organizational Readiness to Change Assessment (ORCA is a measure of organizational readiness for implementing practice change in healthcare settings that is organized based on the core elements and sub-elements of the Promoting Action on Research Implementation in Health Services (PARIHS framework. General support for the reliability and factor structure of the ORCA has been reported. However, no published study has examined the utility of the ORCA in a clinical setting. The purpose of the current study was to examine the relationship between baseline ORCA scores and implementation of hepatitis prevention services in substance use disorders (SUD clinics. Methods Nine clinic teams from Veterans Health Administration SUD clinics across the United States participated in a six-month training program to promote evidence-based practices for hepatitis prevention. A representative from each team completed the ORCA evidence and context subscales at baseline. Results Eight of nine clinics reported implementation of at least one new hepatitis prevention practice after completing the six-month training program. Clinic teams were categorized by level of implementation-high (n = 4 versus low (n = 5-based on how many hepatitis prevention practices were integrated into their clinics after completing the training program. High implementation teams had significantly higher scores on the patient experience and leadership culture subscales of the ORCA compared to low implementation teams. While not reaching significance in this small sample, high implementation clinics also had higher scores on the research, clinical experience, staff culture, leadership behavior, and measurement subscales as compared to low implementation clinics. Conclusions The results of this study suggest that the ORCA was able to measure differences in organizational factors at baseline between clinics that reported high and low implementation of practice

  2. True deficiency of antioxidant vitamins E and A in dialysis patients. Relationship with clinical patterns of atherosclerosis.

    Science.gov (United States)

    Aguilera, Abelardo; Bajo, M Auxiliadora; del Peso, Gloria; Diez, Juan J; Codoceo, Rosa; Rebollo, Francisco; Mariano, Mario; Selgas, Rafael

    2002-01-01

    Atherosclerosis is an important cause of morbidity and mortality in peritoneal dialysis (PD) patients. Oxidative stress plays a role in the pathogenesis of uremic atherosclerosis. Although antioxidant substances (vitamins A and E) are elevated in the plasma of dialysis patients, intracellular and clinical signs of hypovitaminosis are frequently found. Recently, the importance of vitamin/carrier complexes as a marker of vitamin bioavailability has been demonstrated. In the present study, we analyzed vitamin A and E bioavailability, measured as vitamin/carrier complexes, and the relationship of those measurements with clinical atherosclerosis status in PD patients. We studied 45 patients (15 men, 30 women), who were divided into four groups according to clinical atherosclerotic score (CAS). Five cases were scored as CAS grade 1 (low CAS); 9 as CAS-2; 18 as CAS-3; and 13 as CAS-4. Vitamins A and E and their carriers [prealbumin and retinol binding protein (vitamin A), and cholesterol and triglycerides (vitamin E)] were determined. Plasma levels of vitamin A were low in 5 patients, normal in 7 patients, and high in 33 patients. By correcting the values for the carrier levels, we created three groups: 24 patients showed low vitamin A/carrier complex (5 from the low plasma vitamin A group, 6 from the normal-value group, and 13 from the high-value group); 11 patients were in the group with normal vitamin A/carrier (1 from the normal plasma vitamin A group, and 10 from the high-value group); and 10 patients were in the group with high vitamin A/carrier. The vitamin A/carrier complex showed a statistically significant, negative linear correlation with CAS and with serum iron. Low vitamin E plasma levels were found in 1 patient, normal levels in 28 patients, and high levels in 16 patients. When those values were corrected using the carrier values, three groups were also created. The group with low vitamin E/carrier complex contained 24 patients (1 from the low-value group

  3. Relationship between the length of the uterine cavity and clinical pregnancy rates after in vitro fertilization or intracytoplasmic sperm injection.

    Science.gov (United States)

    Chun, Sang Sik; Chung, Min Ji; Chong, Gun Oh; Park, Kee Sang; Lee, Taek Hoo

    2010-02-01

    In this prospective clinical study involving 354 IVF-intracytoplasmic sperm injection cycles, we determined the influence of the length of the uterine cavity on clinical pregnancy rates. Our data showed that clinical pregnancy and implantation rates are associated positively with an increased length of the uterine cavity.

  4. 法国侦查主体有关问题初探——兼与中国侦查主体比较研究%Preliminary Analysis of the issues on Investigation Subject in France --Comparative Study on Investigation Subject in C

    Institute of Scientific and Technical Information of China (English)

    肖军

    2011-01-01

    France is a typical civil law country , the "typical" means strong sense of authority principle. The main investigation subjects, such as the judicial police, prosecutor and pre-trial judge are unique in France. Compared with our country's police, prosecu%法国是典型的大陆法系国家,“典型”意味着职权主义色彩浓厚。而法国的侦查主体,如司法警察、检察官、预审法官都是比较有特色的。通过与我们国家的警察、检察官等相比较,发现两国侦查主体都处在改革阶段,既有相同的发展趋势、规律,又有似是而非的差异之处。只有全面了解、熟悉并深入剖析,才能发现我国改革的症结所在,才能更好地完善侦查主体这一侦查学基础概念的内涵和外延。

  5. Relationship between clinical fieldwork educator performance and health professional students' perceptions of their practice education learning environments.

    Science.gov (United States)

    Brown, Ted; Williams, Brett; Lynch, Marty

    2013-12-01

    The Dundee Ready Education Environment Measure, Clinical Teaching Effectiveness Instrument, and Clinical Learning Environment Inventory were completed by 548 undergraduate students (54.5% response rate) enrolled in eight health professional bachelor degree courses. Regression analysis was used to investigate the significant predictors of the Clinical Teaching Effectiveness Instrument with the Dundee Ready Education Environment Measure and Clinical Learning Environment Inventory subscales as independent variables. The results indicated that the Dundee Ready Education Environment Measure and Clinical Learning Environment Inventory Actual version subscale scores explained 44% of the total variance in the Clinical Teaching Effectiveness Instrument score. The Dundee Ready Education Environment Measure subscale Academic Self-Perception explained 1.1% of the variance in the Clinical Teaching Effectiveness Instrument score. The Clinical Learning Environment Inventory Actual subscales accounted for the following variance percentages in the Clinical Teaching Effectiveness Instrument score: personalization, 1.1%; satisfaction, 1.7%; task orientation, 5.1%; and innovation, 6.2%. Aspects of the clinical learning environment appear to be predictive of the effectiveness of the clinical teaching that students experience. Fieldwork educator performance might be a significant contributing factor toward student skill development and practitioner success.

  6. The relationship between personality traits and psychotic like experiences in a large non-clinical adolescent sample

    NARCIS (Netherlands)

    Wiltink, S.; Nelson, B.; Velthorst, E.; Wigman, J. T. W.; Lin, A.; Baksheev, G.; Cosgrave, E.; Ross, M.; Ryan, J.; Yung, A. R.

    2015-01-01

    Objective: The relationship between personality and psychosis is well established. It has been suggested that this relationship may be partly accounted for by higher levels of depression in individuals with certain personality traits. We explored whether the link between personality and psychotic sy

  7. Differential effects of propofol and isoflurane on the relationship between EEG Narcotrend index and clinical stages of anaesthetic depth in sheep undergoing experimental cardiac surgery.

    Science.gov (United States)

    Otto, Klaus A

    2016-02-01

    The electroencephalogram (EEG) Narcotrend index (NI) has been shown to improve anaesthetic depth monitoring in isoflurane-anaesthetised sheep. Data obtained from 13 anaesthetised juvenile female sheep were analysed retrospectively in order to assess the relationship between clinical stages of anaesthesia (CS) and NI during both propofol and isoflurane anaesthesia. Polynomial regression analysis revealed no significant association between CS and NI for propofol (R = 0.374, R(2) = 0.140, P = 0.403) but for isoflurane anaesthesia (R = 0.548, R(2) = 0.301, P = 0.010) there was a significant relationship. Furthermore, a strong correlation existed between end-tidal isoflurane concentration (ISOET) and CS (r = -0.463, P = 0.008). A combination of assessment of clinical signs and analogous EEG patterns is recommended during propofol anaesthesia.

  8. Analysis of the relationship between periodontal disease and atherosclerosis within a local clinical system: a cross-sectional observational pilot study.

    Science.gov (United States)

    Kudo, Chieko; Shin, Wee Soo; Minabe, Masato; Harai, Kazuo; Kato, Kai; Seino, Hiroaki; Goke, Eiji; Sasaki, Nobuhiro; Fujino, Takemasa; Kuribayashi, Nobuichi; Pearce, Youko Onuki; Taira, Masato; Maeda, Hiroshi; Takashiba, Shogo

    2015-09-01

    It has been revealed that atherosclerosis and periodontal disease may have a common mechanism of "chronic inflammation". Several reports have indicated that periodontal infection is related to atherosclerosis, but none have yet reported such an investigation through the cooperation of local clinics. This study was performed in local Japanese clinics to examine the relationship between periodontal disease and atherosclerosis under collaborative medical and dental care. A pilot multicenter cross-sectional study was conducted on 37 medical patients with lifestyle-related diseases under consultation in participating medical clinics, and 79 periodontal patients not undergoing medical treatment but who were seen by participating dental clinics. Systemic examination and periodontal examination were performed at baseline, and the relationships between periodontal and atherosclerosis-related clinical markers were analyzed. There was a positive correlation between LDL-C level and plasma IgG antibody titer to Porphyromonas gingivalis. According to the analysis under adjusted age, at a cut-off value of 5.04 for plasma IgG titer to Porphyromonas gingivalis, the IgG titer was significantly correlated with the level of low-density lipoprotein cholesterol (LDL-C). This study suggested that infection with periodontal bacteria (Porphyromonas gingivalis) is associated with the progression of atherosclerosis. Plasma IgG titer to Porphyromonas gingivalis may be useful as the clinical risk marker for atherosclerosis related to periodontal disease. Moreover, the application of the blood examination as a medical check may lead to the development of collaborative medical and dental care within the local medical clinical system for the purpose of preventing the lifestyle-related disease.

  9. Cognitive investigation of the relationship between clinical and management staff%临床与管理之间关系的认知调查

    Institute of Scientific and Technical Information of China (English)

    王颖

    2008-01-01

    目的 对临床与管理之间关系的认知情况进行初步探讨,以期加以改善.方法 采用问卷调查的方法,对38名临床一线人员和26名医院管理人员就26项临床与管理关系问题进行调查.结果 两组人员在临床参与管理、双方团结协作及交流沟通、对对方素质和能力的认可等方面具有共识,P>0.05;而在临床与管理互相渗透、权力平衡及政策制度实施等方面存在认知差异.结论 医院临床医生与管理人员双方深入的合作和理解以及行为和观念的相互转换,是建立良好临床与管理关系的前提.%Objective An initial study on the cognition of the relationship between clinical and management staff for the purpose of improvements. Methods Questionnaires were issued to 38 clinical medical staff and 26 hospital management staff, regarding this relationship. Results Consensus is found between the two groups regarding clinical involvement in management, teamwork and exchange, and cognition on the competence and capability of the other party, P>0.05. On the other hand, however,cognitive differences are found regarding mutual penetration, power balance and implementation of policies and systems. Conclusions In-depth cooperation and understanding between the two groups and the mutual conversion of their behaviors and concepts are the cornerstones of an ideal relationship between clinical staff and management staff.

  10. Immediate effect of couple relationship education on low-satisfaction couples: a randomized clinical trial plus an uncontrolled trial replication.

    Science.gov (United States)

    Kim Halford, W; Pepping, Christopher A; Hilpert, Peter; Bodenmann, Guy; Wilson, Keithia L; Busby, Dean; Larson, Jeffry; Holman, Thomas

    2015-05-01

    Couple relationship education (RE) usually is conceived of as relationship enhancement for currently satisfied couples, with a goal of helping couples sustain satisfaction. However, RE also might be useful as a brief, accessible intervention for couples with low satisfaction. Two studies were conducted that tested whether couples with low relationship satisfaction show meaningful gains after RE. Study 1 was a three-condition randomized controlled trial in which 182 couples were randomly assigned to RELATE with Couple CARE (RCC), a flexible delivery education program for couples, or one of two control conditions. Couples with initially low satisfaction receiving RCC showed a moderate increase in relationship satisfaction (d=0.50) relative to the control. In contrast, couples initially high in satisfaction showed little change and there was no difference between RCC and the control conditions. Study 2 was an uncontrolled trial of the Couple Coping Enhancement Training (CCET) administered to 119 couples. Couples receiving CCET that had initially low satisfaction showed a moderate increase in satisfaction (g=.44), whereas initially highly satisfied couples showed no change. Brief relationship education can assist somewhat distressed couples to enhance satisfaction, and has potential as a cost-effective way of enhancing the reach of couple interventions.

  11. Magnetic Resonance Imaging of Patients With Chronic Lateral Epicondylitis: Is There a Relationship Between Magnetic Resonance Imaging Abnormalities of the Common Extensor Tendon and the Patient's Clinical Symptom?

    Science.gov (United States)

    Qi, Liang; Zhang, Yu-Dong; Yu, Rong-Bin; Shi, Hai-Bin

    2016-02-01

    The aim of the study is to determine the inter-reliability and intra-observer reliability of magnetic resonance imaging (MRI) for lateral epicondylitis and investigate whether there is a potential relationship between MRI abnormalities of the common extensor tendon (CET) and its clinical symptom.The study group comprised 96 consecutive patients (46 men and 50 women) with a clinical diagnosis of chronic lateral epicondylitis, which were examined on 3.0 T MR. An MRI scoring system was used to grade the degree of tendinopahty. Three independent musculoskeletal radiologists, who were blinded to the patients' clinical information, scored images separately. Clinical symptoms were assessed using the Patient-Rated Tennis Elbow Evaluation (PRTEE).Of all the patients, total 96 elbows had MRI-assessed tendinopathy, including 38 (39.6%) with grade 1, 31 (32.3%) with grade 2, and 27 (28.1%) with grade 3. Inter-observer reliability and intra-observer agreement for MRI interpretation of the grades of tendinopathy was good, and a positive correlation between the grades of tendinopathy and PRTEE was determined.MRI is a reliable tool in determining radiological severity of chronical lateral epicondylitis. The severity of MR signal changes positively correlate with the patient's clinical symptom.

  12. European Academy of Allergy and Clinical Immunology task force report on 'dose-response relationship in allergen-specific immunotherapy'

    DEFF Research Database (Denmark)

    Calderón, M A; Larenas, D; Kleine-Tebbe, J;

    2011-01-01

    For a century, allergen-specific immunotherapy (SIT) has proven to be an effective treatment for allergic rhinitis, asthma, and insect sting allergy. However, as allergen doses are frequently adapted to the individual patient, there are few data on dose-response relationship in SIT. Allergen prod...

  13. The Role of Loneliness in the Relationship between Anxiety and Depression in Clinical and School-Based Youth

    Science.gov (United States)

    Ebesutani, Chad; Fierstein, Matthew; Viana, Andres G.; Trent, Lindsay; Young, John; Sprung, Manuel

    2015-01-01

    Identifying mechanisms that explain the relationship between anxiety and depression are needed. The Tripartite Model is one model that has been proposed to help explain the association between these two problems, positing a shared component called negative affect. The objective of the present study was to examine the role of loneliness in relation…

  14. Stress-Reactive Rumination, Negative Cognitive Style, and Stressors in Relationship to Depressive Symptoms in Non-Clinical Youth

    Science.gov (United States)

    Rood, Lea; Roelofs, Jeffrey; Bogels, Susan M.; Meesters, Cor

    2012-01-01

    The role of cognitive vulnerability in the development of depressive symptoms in youth might depend on age and gender. The current study examined cognitive vulnerability models in relationship to depressive symptoms from a developmental perspective. For that purpose, 805 youth (aged 10-18, 59.9% female) completed self-report measures.…

  15. Prescribing patterns for thiazide diuretics in a large health maintenance organization: relationship to participation as an ALLHAT clinical center.

    Science.gov (United States)

    Petitti, Diana B; Xie, Fagen; Barzilay, Joshua I

    2006-10-01

    The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) published its main findings in December, 2002. It recommended thiazide diuretics as a first-line treatment of hypertension. The current study describes the prescribing patterns of thiazide diuretics in four regions of Kaiser Permanente, a large national United States Health Maintenance Organization--two regions that had an ALLHAT clinical center and two that did not. We tested the hypothesis that participation in a clinical trial leads to quicker and greater adoption of study recommendations than non-participation in a trial. The relative percentage of filled outpatient prescriptions for the period 2 or 3 years before the ALLHAT main publication through December 31, 2004 was calculated by region for thiazide-type diuretics and for calcium channel blockers (CCBs), beta-blockers, central alpha-blockers, angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs) and other antihypertensive diuretics. In the 2 years after publication of the ALLHAT trial findings, the percentage of all prescriptions for thiazide diuretics increased from 11.2% to 12.4% in the two regions with an ALLHAT clinical site and from 8.9% to 10.1% in the two regions without an ALLHAT clinical site (p > 0.05). The percentage of new prescriptions for thiazide diuretics increased from 13.7% to 16.6% in the two regions with an ALLHAT clinical site and from 10.8% to 13.0% in the two regions without an ALLHAT clinical site (p > 0.05). Participation in a clinical hypertension study does not appear to accelerate adoption of study recommendations.

  16. Reduced sensitivity of red blood cell (Na+,K+)-ATPase to ethanol in vitro in male alcoholic patients: relationship to clinical characteristics.

    Science.gov (United States)

    Swann, A C; Reilly, E; Overall, J E

    1986-10-01

    We examined red blood cell (Na+,K+)-ATPase, its sensitivity to inhibition by ethanol in vitro, and its relationship to clinical characteristics and history in 41 newly admitted alcoholic patients and 14 age-matched healthy controls. Sensitivity to ethanol was significantly lower in the alcoholic patients and correlated negatively with ethanol intake. In addition, sensitivity of enzyme to ethanol was lower in patients with high agitation-anxiety ratings and correlated negatively with agitation and anxiety scores on the Brief Psychiatric Rating Scale. There were no relationships between (Na+,K+)-ATPase measures and depressive symptoms, history of treatment for depression, or family history of depression. These data suggest that tolerance to the effects of ethanol on (Na+,K+)-ATPase occurs in man and may be related to the severity of ethanol dependence or withdrawal.

  17. Understanding the relationship transitions and associated end of life clinical needs of young adults with life-limiting illnesses: A triangulated longitudinal qualitative study

    Directory of Open Access Journals (Sweden)

    Bridget Johnston

    2016-10-01

    Full Text Available Background: Care of young adults with life-limiting illnesses can often be complex due to the fact that they are growing and developing within the continuing presence of their illness. There is little research conducted nationally and internationally, which has examined the life issues of young adults or taken a longitudinal approach to understand such issues over a period of time. Aim: To gain clear understanding of one particular and pertinent life issue—relationship transition—occurring in the context of being a young adult with a life-limiting illness and the clinical needs arising from this. Design: This was a triangulated, longitudinal, qualitative study involving young adults with life-limiting illnesses and their significant others, namely, family members and healthcare professionals. Semi-structured interviews were conducted with participants and analysed using thematic analysis. Clinical case note reviews were also carried out. Setting/participants: A total of 12 young adults (aged between 17 and 23 years from 2 hospices and 22 nominated significant others participated in a total of 58 interviews. Results: Thematic analysis revealed 4 main themes and 11 subthemes. The main themes were ‘Dependence dichotomy’, ‘In it together’, ‘Biographical uncertainty’, and ‘Conserving integrity’. These themes helped to establish the nature of relationship transitions that the young adult participants from the study experienced and additionally allowed insight into their possible needs at their end of life. Conclusion: This study has identified the nature of relationship transitions pertinent to young adults and has highlighted associated end of life clinical needs. This study can influence further research into the transitions and end of life needs of this particular patient group receiving palliative care, while informing the lacking evidence base which exists internationally.

  18. Relationships between high-stakes clinical skills exam scores and program director global competency ratings of first-year pediatric residents

    Directory of Open Access Journals (Sweden)

    Erik E. Langenau

    2011-09-01

    Full Text Available Responding to mandates from the Accreditation Council for Graduate Medical Education (ACGME and American Osteopathic Association (AOA, residency programs have developed competency-based assessment tools. One such tool is the American College of Osteopathic Pediatricians (ACOP program directors’ annual report. High-stakes clinical skills licensing examinations, such as the Comprehensive Osteopathic Medical Licensing Examination Level 2-Performance Evaluation (COMLEX-USA Level 2-PE, also assess competency in several clinical domains.The purpose of this study is to investigate the relationships between program director competency ratings of first-year osteopathic residents in pediatrics and COMLEX-USA Level 2-PE scores from 2005 to 2009.The sample included all 94 pediatric first-year residents who took COMLEX-USA Level 2-PE and whose training was reviewed by the ACOP for approval of training between 2005 and 2009. Program director competency ratings and COMLEX-USA Level 2-PE scores (domain and component were merged and analyzed for relationships.Biomedical/biomechanical domain scores were positively correlated with overall program director competency ratings. Humanistic domain scores were not significantly correlated with overall program director competency ratings, but did show moderate correlation with ratings for interpersonal and communication skills. The six ACGME or seven AOA competencies assessed empirically by the ACOP program directors’ annual report could not be recovered by principal component analysis; instead, three factors were identified, accounting for 86% of the variance between competency ratings.A few significant correlations were noted between COMLEX-USA Level 2-PE scores and program director competency ratings. Exploring relationships between different clinical skills assessments is inherently difficult because of the heterogeneity of tools used and overlap of constructs within the AOA and ACGME core competencies.

  19. Understanding the relationship transitions and associated end of life clinical needs of young adults with life-limiting illnesses: A triangulated longitudinal qualitative study

    Science.gov (United States)

    Johnston, Bridget; Jindal-Snape, Divya; Pringle, Jan; Gold, Libby; Grant, Jayne; Dempsey, Raymond; Scott, Ros; Carragher, Pat

    2016-01-01

    Background: Care of young adults with life-limiting illnesses can often be complex due to the fact that they are growing and developing within the continuing presence of their illness. There is little research conducted nationally and internationally, which has examined the life issues of young adults or taken a longitudinal approach to understand such issues over a period of time. Aim: To gain clear understanding of one particular and pertinent life issue—relationship transition—occurring in the context of being a young adult with a life-limiting illness and the clinical needs arising from this. Design: This was a triangulated, longitudinal, qualitative study involving young adults with life-limiting illnesses and their significant others, namely, family members and healthcare professionals. Semi-structured interviews were conducted with participants and analysed using thematic analysis. Clinical case note reviews were also carried out. Setting/participants: A total of 12 young adults (aged between 17 and 23 years) from 2 hospices and 22 nominated significant others participated in a total of 58 interviews. Results: Thematic analysis revealed 4 main themes and 11 subthemes. The main themes were ‘Dependence dichotomy’, ‘In it together’, ‘Biographical uncertainty’, and ‘Conserving integrity’. These themes helped to establish the nature of relationship transitions that the young adult participants from the study experienced and additionally allowed insight into their possible needs at their end of life. Conclusion: This study has identified the nature of relationship transitions pertinent to young adults and has highlighted associated end of life clinical needs. This study can influence further research into the transitions and end of life needs of this particular patient group receiving palliative care, while informing the lacking evidence base which exists internationally. PMID:27781097

  20. Relationship between season, lactation number and incidence of clinical mastitis in different stages of lactation in a Holstein dairy farm

    OpenAIRE

    Maede Moosavi; Abdolah Mirzaei; Mohsen Ghavami; Amin Tamadoد

    2014-01-01

    The aim of the present study was to compare the occurrence and duration of clinical mastitis in different seasons, stages of lactation period and parities in a Holstein dairy farm in Iran. A retrospective epidemiological survey from April 2005 to March 2008 was conducted on 884 clinical mastitis cases of 7437 lactations. Data of each case including calendar-date of mastitis onset, days in milk (DIM) of mastitis onset (early: 0-74 DIM; middle: 75-150 DIM, and late ≥ 150 DIM), duration of masti...

  1. Relationship between expression of α-fetoprotein messenger RNA and some clinical parameters of human hepatocellular carcinoma

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    AIM To certify the relationship between AFP mRNA and some pathological parameters of he-patocellular carcinoma (HCC).METHOD We detected the expression of AFP in mRNA level in tissue samples from 52 patients suffering from HCC by RT-PCR method.RESULTS The positive rate of AFP mRNA was 76.9% in the HCC tumor tissues, and 69.4% in the paratumor tissues from the HCC patients with severe cirrhosis. However, in HCC patients without cirrhosis, the positive rate reached 50% in tumor tissues, but no AFP mRNA expression was found in the related paratumor tissues.CONCLUSION The AFP protein was specially expressed by HCC cells and mutated hepatocytes. The AFP mRNA was positively related with cirrhosis, but no significant relationship was found between AFP mRNA and tumor size, capsule status and tumor metastasis.

  2. Negative affect mediates the relationship between interpersonal problems and binge-eating disorder symptoms and psychopathology in a clinical sample: a test of the interpersonal model.

    Science.gov (United States)

    Ivanova, Iryna V; Tasca, Giorgio A; Hammond, Nicole; Balfour, Louise; Ritchie, Kerri; Koszycki, Diana; Bissada, Hany

    2015-03-01

    This study evaluated the validity of the interpersonal model of binge-eating disorder (BED) psychopathology in a clinical sample of women with BED. Data from a cross-sectional sample of 255 women with BED were examined for the direct effects of interpersonal problems on BED symptoms and psychopathology, and indirect effects mediated by negative affect. Structural equation modelling analyses demonstrated that higher levels of interpersonal problems were associated with greater negative affect, and greater negative affect was associated with higher frequency of BED symptoms and psychopathology. There was a significant indirect effect of interpersonal problems on BED symptoms and psychopathology mediated through negative affect. Interpersonal problems may lead to greater BED symptoms and psychopathology, and this relationship may be partially explained by elevated negative affect. The results of the study are the first to provide support for the interpersonal model of BED symptoms and psychopathology in a clinical sample of women.

  3. An Examination of the Relationship of the AMEDD Population Health Clinical Optimization Training with Change in Patient and Staff Satisfaction

    Science.gov (United States)

    2006-05-31

    Journal of Clinical Outcomes Management, 8(7), 21-25. Mertz, M. G. (1999). What does Walt Disney know about patient satisfaction? Family Practice...and some of us being contract. Stop stereotyping people for this. Teamwork is the key to good quality medical care. Comments: None CNA Civilian GS

  4. Magnetic resonance imaging-based measures of atlas position: Relationship to canine atlantooccipital overlapping, syringomyelia and clinical signs.

    Science.gov (United States)

    Cerda-Gonzalez, S; Bibi, K F; Gifford, A T; Mudrak, E L; Scrivani, P V

    2016-03-01

    Canine atlantooccipital overlapping (AOO) is characterized by a decreased distance between the dorsal arch of the atlas and the supraoccipital bone. Current diagnostic criteria for this condition are subjective and clinician-dependent; objective criteria are needed to allow a reliable and reproducible diagnosis in clinical and research settings and assess clinical significance. We propose four standardized MRI-based measurements to objectively assess the proximity of the atlas to the foramen magnum. Inclusion criteria for dogs in this study were bodyweight 5 months, and availability of a complete MRI study performed with the craniocervical junction in extension. Exclusion criteria were space-occupying lesions and poor image quality (i.e. unclear bony margins). Measurements also included blinded determinations of skull type, presence of craniocervical junction anomalies and presence and severity of syringomyelia. Clinical status at the time of imaging was noted. Measurements were obtained in 271 dogs; these were reproducible and reliable. Findings varied by skull type: dolichocephalic dogs had smaller foramen magnum, whereas brachycephalic dogs had more cranially and dorsally positioned atlas bodies in comparison to the other skull types. Measurements also increased with increases in bodyweight. This study demonstrated a close association between AOO, syringomyelia and clinical signs. Toy and small breed dogs (including Cavalier King Charles spaniels) showed higher than previously reported prevalence of AOO; its occurrence was also associated with lower bodyweights within the study population of <15 kg toy/small breed dogs.

  5. An Exploration of the Relationship between Clinical Decision-Making Ability and Educational Preparation among New Graduate Nurses

    Science.gov (United States)

    Blount, Kamilah V.

    2013-01-01

    This study examined the impact of accelerated nursing direct entry master's programs on the development of clinical decision-making skills of new graduate nurses that completed the Performance Based Development System (PBDS) assessment during the study period of 2008-2012 at a healthcare organization. Healthcare today is practiced in a…

  6. The relationship between clinical signs of respiratory system disorders and lung lesions at slaughter in veal calves

    NARCIS (Netherlands)

    Leruste, H.; Brscic, M.; Ruis-Heutinck, L.F.M.; Visser, E.K.; Wolthuis-Fillerup, M.; Bokkers, E.A.M.; Stockhofe-Zurwieden, N.; Cozzi, G.; Gottardo, F.; Lensink, B.J.; Reenen, van C.G.

    2012-01-01

    The presence and severity of lung lesions recorded post-mortem is commonly used as an indicator to assess the prevalence of respiratory problems in batches of bovines. In the context of a welfare monitoring based on on-farm measures, the recording of clinical signs on calves at the farm would be mor

  7. On the Relationship between Autistic Traits and Executive Functioning in a Non-Clinical Dutch Student Population

    Science.gov (United States)

    Maes, Joseph HR; Vissers, Constance ThWM; Egger, Jos IM; Eling, Paul ATM

    2013-01-01

    We examined the association between autistic traits and different aspects of executive functioning (EF), using non-clinical Social Science and Science students as participants. Autistic traits, and associated personality traits, were measured using the Autism Quotient (AQ) and the Temperament and Character Inventory (TCI), respectively. EF was…

  8. Tongue diagnosis:relationship between sublingual tongue morphology in three tongue protrusion angles and menstrual clinical symptoms

    Institute of Scientific and Technical Information of China (English)

    Tim Hideaki Tanaka

    2015-01-01

    OBJECTIVE:The morphological and color characteristics of the tongue sublingual veins (SLVs) can manifest differently within the subjects, depending on the way their tongue is curled upward. This study was conducted in order to investigate the clinical relevancy of tongue SLV diagnosis in relation to menstrual clinical symptoms (pain, clots, heavy, and scanty), using three different inspection procedures (IP1, IP2, and IP3). METHODS: Three-hundred and seventy-seven female patients were asked to stick out their tongues in three speciifc ways which were intended to create different tongue protrusion angles. The SLV parameters for thickness (TK), length (LE), color (CL), shape (SP), and nodules (ND) were then evaluated. RESULTS: According to the results of the Waldχ2 test, IP1 provides the best model for pain (R2 = 0.155), IP3 for clots (R2 = 0.437), IP2 for heavy (R2 = 0.268), and scanty (R2 = 0.192). Abnormal SLV diagnostic parameters were most strongly associated with the clinical symptom of clots (R2= 0.492). CONCLUSION: While the study showed the relations between tongue SLV features and menstrual clinical symptoms, as wel it showed that IP2 was the best overal predictor for the symptomatic indexes used in this study, and using one particular SLV inspection procedure may not be sufifcient. The application of a particular inspection method alone may cause under- or over-estimation of SLV abnormalities.

  9. Relationship of white and gray matter abnormalities to clinical and genetic features in myotonic dystrophy type 1

    Directory of Open Access Journals (Sweden)

    Stefano Zanigni

    2016-01-01

    Conclusion: In patients with DM1, the combined smaller overall gray matter volume and white matter alterations seem to be the main morpho-structural substrates of CNS involvement in this condition. The correlation of white matter differences with both clinical and genetic findings lends support to this notion.

  10. Relationship between lower number of oocytes retrieved and clinical outcomes of in vitro fertilization-embryo transfer

    Institute of Scientific and Technical Information of China (English)

    Wang Xue-mei; Jiang Hong; Zhang Wen-xiang; Wei Zhao-lian

    2012-01-01

    Objective: To explore the clinical outcomes of the infertile women with retrieved oocytes less than or equal to 5 undergoing in vitro fertilization-embryo transfer (IVF-ET) or intracytoplasmic sperm injection (ICSI).Methods: The clinical data of 216 embryo transfer cycles with retrieved oocytes less than or equal to 5 during the procedure of IVF/ICSI in Reproductive Medicine Center of the 105th Hospital of PLA from Jul.2008 to Dec.2011 were analyze retrospectively.All the patients were divided into group A (< 35 years),group B (35-39 years) and group C (≥40 years) according to the ages,and 409 IVF/ICSI cycles with patients’ age less than 35 years old and 6-15 retrieved oocytes in the same period were served as controlled group.Then the patients ≥ 35 years were subdivided into gonadotropin-releasing hormone agonist (GnRH-a) long protocol group,GnRH-a short group and GnRH antagonist group according to the protocols of controlled ovarian hyperstimulation (COH).The clinical date and the outcomes were analyzed and compared among all groups.Results: There were significantly differences in clinical pregnancy rate (38.3 % vs.19.4 %) and early abortion rate (16.1% vs.50.0%) between group A and group C (P<0.05),and there were no significant differences in clinical pregnancy rate(38.3% vs.41.6%)and early abortion rate (16.1% vs.10.0%) between group A and control group (P>0.05).There were no significant differences in clinical pregnancy rates (29.01% vs.26.1% vs.25.9%)and early abortion rates (33.3% vs.33.3% vs.40.0%) among GnRH-a long protocol group,GnRH-a short group and GnRH antagonist group (P>0.05).Conclusions: Relatively satisfactory clinical outcomes of IVF/ICSI would still be got for the patients <35 years with retrieved oocytes less than or equal to 5,but whatever COH protocols such as GnRH-a long protocol,GnRH-a short and GnRH antagonist could not improve the outcomes of IVF/ICSI for the patients aged ≥35 with retrieved

  11. Relationship between clinical and BK virological response in patients with late hemorrhagic cystitis treated with cidofovir: a retrospective study from the European Group for Blood and Marrow Transplantation.

    Science.gov (United States)

    Cesaro, S; Pillon, M; Tridello, G; Aljurf, M; Martino, R; Schroyens, W; Nozzoli, C; Barba, P; Faraci, M; Fagioli, F; Cappelli, B; Cordonnier, C; Al-Mohareb, F; Floisand, Y; Greil, J; Panizzolo, I S; Santarone, S

    2013-06-01

    To investigate the relationship between clinical response and modification of BK viremia, we assessed retrospectively 32 cases of hemorrhagic cystitis (HC) after allogeneic hematopoietic SCT that were treated with i.v. cidofovir (CDV). They were 22 men (69%) and 10 women (31%) with a median age of 24 years, range 3-62. The median number of CDV doses was 3, range 1-8, and the treatment lasted for a median of 3 weeks, range 1-10. Clinical improvement of HC was observed in 27 patients (84%). In 12 of 32 episodes (37.5%), BK viremia was determined before every CDV administration and a complete clinical response was observed in 10 of 12 patients (83%), the reduction of BK viremia load being 1 log by 2 weeks after starting CDV. Nephrotoxicity related to CDV was observed in nine patients. Among 26 patients with 100-day follow-up, 4 of 4 patients who had a complete clinical response by 30 days were alive vs 16 of 22 (73%) who did not have the resolution of HC in this time frame. We conclude that in patients with HC, the response to CDV treatment is usually associated with a significant reduction of BK viremia load.

  12. Relationship between serologic response and clinical symptoms in children with enterovirus 71-infected hand-foot-mouth disease

    OpenAIRE

    Shen, Jun; Zhao,Chao; Cao, Ping; Shi, Peng; Cao, Lingfeng; Zhu, Qirong

    2015-01-01

    This study aimed to explore the correlation between clinical symptoms, including rash and fever, and serum antibody reaction to enterovirus 71 (EV71) infection in children hospitalized due to hand-foot-mouth disease (HFMD). From May 2014 to July 2014, a total of 547 children hospitalized due to HFMD in Children’s Hospital of Fudan University were enrolled retrospectively. RNA levels of EV71 and CA16 in fecal, serum, and cerebrospinal fluid specimens were measured using quantitative real-time ...

  13. Longitudinal Study of the Relationship among Craniocervical Morphology, Clinical Progression, and Syringomyelia in a Cohort of Cavalier King Charles Spaniels

    OpenAIRE

    Cerda‐Gonzalez, S.; Olby, N.J.; Griffith, E.H.

    2016-01-01

    Background Craniocervical junction (CCJ) anomalies and secondary syringomyelia are commonly diagnosed in Cavalier King Charles spaniel (CKCS). Familiarity with the natural history of these abnormalities is vital to understanding the disease syndrome. Objective To evaluate magnetic resonance imaging (MRI) predictors of worsening clinical signs, syringomyelia, and morphology in CKCS longitudinally. Animals Fifty‐four client‐owned CKCS, 5–13 years old; 50% currently symptomatic. Methods Longitud...

  14. The study of relationship between reported temporomandibular symptoms and clinical dysfunction index among university students in Shiraz

    Directory of Open Access Journals (Sweden)

    Mahroo Vojdani

    2012-01-01

    With respect to gender, women (80% were more affected than men (62%. A significant relationship was found between gender and the occurrence of temporomandibular disorder (TMD (P<0.05. The correlation coefficient (r between the reported symptoms (Ai and recorded signs (Di was 0.53. There were positive correlation coefficient between Di and Ai. They were statistically significant (P<0.001. Conclusions: A high prevalence of signs and symptoms of TMD among students in Shiraz University of Medical Sciences was seen, which was greater in women. Despite suffering from TMD, students were not aware of their disorders.

  15. Evaluation of the Cerebral State Index in Cats under Isoflurane Anaesthesia: Dose-Effect Relationship and Prediction of Clinical Signs

    Directory of Open Access Journals (Sweden)

    Joana R. Sousa

    2014-01-01

    Full Text Available The performance of the cerebral state index (CSI in reflecting different levels of isoflurane anaesthesia was evaluated in ten cats subjected to four end-tidal isoflurane concentrations (EtIso, each maintained for 15 minutes (0.8%, 1.2%, 1.6%, or 2.0% EtIso. The CSI, hemodynamic data, ocular reflexes, and eye position were recorded for each EtIso concentration. Pharmacodynamic analysis of CSI with EtIso was performed, as well as prediction probability analysis with a clinical scale based on the eye reflexes. The CSI values showed great variability. Between all parameters, burst suppression ratio showed the better fitting with the sigmoidal concentration-effect model (R2=0.93 followed by CSI (R2=0.82 and electromyographic activity (R2=0.79. EtIso was the variable with better prediction of the clinical scale of anaesthesia (prediction probability value of 0.94. Although the CSI values decrease with increasing isoflurane concentrations, the huge variability in CSI values may be a strong limitation for its use in cats and it seems to be no better than EtIso as a predictor of clinical signs.

  16. The relationship of hardiness and social support to student appraisal of stress in an initial clinical nursing situation.

    Science.gov (United States)

    Pagana, K D

    1990-06-01

    The stressful nature of the clinical experience of nursing students was examined within the context of Lazarus' theory of cognitive appraisal of stress. The students' evaluation of their initial medical-surgical clinical experience as a threat or a challenge was determined along with the hypothesized mediating variables of hardiness and social support. The sample of 246 students from seven different colleges and universities in Pennsylvania completed a hardiness measure, the Norbeck Social Support Questionnaire (NSSQ), and a Clinical Stress Questionnaire (CSQ). Although the correlations were low, hardiness was found to be positively related to the evaluation of challenge and negatively related to the evaluation of threat. Social support was positively related to the evaluation of challenge only when using a work-related measure of support. The hypothesis that social support would be negatively related to the evaluation of threat was not supported. This research raises important questions related to the theories of hardiness, social support, and cognitive appraisal of stress. Implications for further research in this area are offered.

  17. Progressive outer retinal necrosis syndrome: a comprehensive review of its clinical presentation, relationship to immune system status, and management.

    Science.gov (United States)

    Austin

    2000-12-01

    Progressive outer retinal necrosis (PORN) syndrome is a form of the Varicella zoster virus (VZV) chorioretinitis found almost exclusively in people with the acquired immunodeficiency syndrome (AIDS). This destructive infection has an extremely rapid course that may lead to no light perception in affected eyes within days or weeks. Attempts at its treatment have had limited success. Rhegmatogenous retinal detachments often occur after the development of atrophic retinal holes, and silicone oil temponade has been found to be the most successful reattachment procedure. Unfortunately, cataract formation is common after such surgery. PORN needs to be differentiated from acute retinal necrosis (ARN) syndrome, a necrotizing retinitis that can also be caused by VZV. PORN and ARN are found at opposite ends of the spectrum of necrotizing herpetic retinopathies (NHR), where its clinical presentation depends upon immune system status. After a brief case presentation, the distinguishing clinical characteristics of PORN, its differentiation from ARN, attempts at its treatment, the role of the immune system status on its clinical appearance and treatment, and management of complications such as retinal detachment and subsequent cataracts are discussed.

  18. On Better Estimating and Normalizing the Relationship between Clinical Parameters: Comparing Respiratory Modulations in the Photoplethysmogram and Blood Pressure Signal (DPOP versus PPV

    Directory of Open Access Journals (Sweden)

    Paul S. Addison

    2015-01-01

    Full Text Available DPOP (ΔPOP or Delta-POP is a noninvasive parameter which measures the strength of respiratory modulations present in the pulse oximeter waveform. It has been proposed as a noninvasive alternative to pulse pressure variation (PPV used in the prediction of the response to volume expansion in hypovolemic patients. We considered a number of simple techniques for better determining the underlying relationship between the two parameters. It was shown numerically that baseline-induced signal errors were asymmetric in nature, which corresponded to observation, and we proposed a method which combines a least-median-of-squares estimator with the requirement that the relationship passes through the origin (the LMSO method. We further developed a method of normalization of the parameters through rescaling DPOP using the inverse gradient of the linear fitted relationship. We propose that this normalization method (LMSO-N is applicable to the matching of a wide range of clinical parameters. It is also generally applicable to the self-normalizing of parameters whose behaviour may change slightly due to algorithmic improvements.

  19. Relationship Between Severity Classification of Acute Exacerbation of Chronic Obstructive Pulmonary Disease and Clinical Outcomes in Hospitalized Patients

    Science.gov (United States)

    Sanjuán, Pilar; Huerta, Arturo; Nieto-Codesido, Irene; Ferreira-Gonzalez, Lucía; Sibila, Oriol; Restrepo, Marcos I

    2017-01-01

    Background Limited data are available regarding the impact of the potential validation of the Canadian Thoracic Society (CTS) guidelines recommendations in classifying patients with an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in simple and complex. The aim of the present study was to assess the CTS recommendations regarding risk stratification on clinical outcomes among patients hospitalized with an AECOPD. Methods We developed a retrospective cohort study of patients admitted to one tertiary hospital with a diagnosis of AECOPD. The main clinical outcome was the percentage of treatment failure. Secondary outcomes were 30-day, 90-day, and 1-year readmission and mortality rate, length of stay in hospital, intensive care unit (ICU) admission rate, time to readmission, and time to death. Multivariate analyses were performed using 1-year mortality rate as the dependent measures. Results One hundred forty-three patients composed the final study population, most of them (106 [74.1%)] classified as complex acute exacerbation (C-AE) of COPD. C-AE patients had similar rate of treatment failure compared with simple acute exacerbation (S-AE) of COPD (31.1% vs. 27%; p = 0.63). There were no differences regarding the length of stay in hospital, ICU admission rate, and 30-day, 90-day, and 1-year readmission rate. C-AE patients had faster declined measures on time to death (691.6 ± 430 days vs. 998.1 ± 355 days; p = 0.02). In the multivariate analysis, after adjusting for comorbidity, lung function and previous treatment, C-AE patients had a significant higher mortality at one year (Odds Ratio [OR] = 4.9 (Confidence Interval [CI] 95%: 1.16-21); p = 0.031). Conclusions In hospitalized patients with an AECOPD, CTS classification, according to the presence of risk factors, was not associated with worse short-term clinical outcomes although it is related with long-term mortality. 

  20. Relationship between acne vulgaris and attention-deficit/hyperactivity disorder symptoms in a clinical sample of women*

    Science.gov (United States)

    Bilgic, Ayhan; Bilgic, Özlem; Çolak, Rukiye Sivri; Altınyazar, Hilmi Cevdet

    2016-01-01

    Acne vulgaris has recently been reported to be associated with elevated rates of attention deficit/hyperactivity disorder in epidemiological studies. This report examines childhood and current attention-deficit/hyperactivity disorder symptoms in a clinical sample of female adults. Ninety-one women with acne vulgaris and 53 controls were included in this study. The aforementioned symptoms were measured in participants. No significant differences were found between patients and controls in any of the measurements. Contrary to the findings of epidemiological studies, this study did not uncover a link between acne vulgaris and attention-deficit/hyperactivity disorder PMID:27192533

  1. Moral Reasoning among HEC Members: An Empirical Evaluation of the Relationship of Theory and Practice in Clinical Ethics Consultation.

    Science.gov (United States)

    Wasserman, Jason Adam; Stevenson, Shannon Lindsey; Claxton, Cassandra; Krug, Ernest F

    2015-01-01

    In light of the ongoing development and implementation of core competencies in bioethics, it is important to proceed with a clear sense of how bioethics knowledge is utilized in the functioning of hospital ethics committees (HECs). Without such an understanding, we risk building a costly edifice on a foundation that is ambiguous at best. This article examines the empirical relationship between traditional paradigms of bioethics theory and actual decision making by HEC members using survey data from HEC members. The assumption underlying the standardization of qualifications and corresponding call for increased education of HEC members is that they will base imminent case decisions on inculcated knowledge. Our data suggest, however, that HEC members first decide intuitively and then look for justification, thereby highlighting the need to re-examine the pedagogical processes of ethics education in the process of standardizing and improving competencies.

  2. Cigarette smoking in male patients with chronic schizophrenia in a Chinese population: prevalence and relationship to clinical phenotypes.

    Directory of Open Access Journals (Sweden)

    Xiang Yang Zhang

    Full Text Available The high prevalence of smoking in schizophrenia of European background may be related to smoking's reducing clinical symptoms and medication side effects. Because smoking prevalence and its associations with clinical phenotypes are less well characterized in Chinese than European patients with schizophrenia, we assessed these smoking behaviors using clinician-administered questionnaires and the Fagerstrom Test for Nicotine Dependence (FTND in 776 Chinese male schizophrenia and 560 control subjects. Patients also were rated on the Positive and Negative Symptom Scale (PANSS, the Simpson and Angus Extrapyramidal Symptom Rating Scale (SAES, and the Abnormal Involuntary Movement Scale (AIMS. We found that the schizophrenia patients had a higher lifetime incidence of smoking (79% vs 63%, were more likely to be heavy smokers (61% vs 31%, and had lower smoking cessation rates (4% vs 9% (all p0.05 than the non-smoking patients. These results suggest that Chinese males with schizophrenia smoke more frequently than the general population. Further, smokers with schizophrenia may display fewer negative symptoms and possibly less parkinsonism than non-smokers with schizophrenia.

  3. Relationship between clinical site of isolation and ability to form biofilms in vitro in nontypeable Haemophilus influenzae.

    Science.gov (United States)

    Obaid, Najla A; Jacobson, Glenn A; Tristram, Stephen

    2015-03-01

    Nontypeable Haemophilus influenzae (NTHi) is an opportunistic pathogen associated with a range of infections, including various lower respiratory infections, otitis media, and conjunctivitis. There is some debate as to whether or not NTHi produces biofilms and, if so, whether or not this is relevant to pathogenesis. Although many studies have examined the association between in vitro biofilm formation and isolates from a specific infection type, few have made comparisons from isolates from a broad range of isolates grouped by clinical source. In our study 50 NTHi from different clinical sources, otitis media, conjunctivitis, lower respiratory tract infections in both cystic fibrosis and non-cystic fibrosis patients, and nasopharyngeal carriage, plus 10 nasopharyngeal isolates of the commensal Haemophilus haemolyticus were tested for the ability to form biofilm by using a static microtitre plate crystal violet assay. A high degree of variation in biofilm forming ability was observed across all isolates, with no statistically significant differences observed between the groups, with the exception of the isolates from conjunctivitis. These isolates had uniformly lower biofilm forming ability compared with isolates from the other groups (p < 0.005).

  4. Relationship between the clinical characteristics of osteomyelitis and the finding of extraosseous fat on MRI in pediatric patients

    Energy Technology Data Exchange (ETDEWEB)

    Mattis, Tod A. [Spectrum Health Helen Devos Children' s Hospital, Grand Rapids, MI (United States); Michigan State University, College of Human Medicine, Radiology, Grand Rapids, MI (United States); Grand Rapids Medical Education Partners, Grand Rapids, MI (United States); Borders, Heather L.; Ellinger, Doug M.; Junewick, Joseph J. [Spectrum Health Helen Devos Children' s Hospital, Grand Rapids, MI (United States); Michigan State University, College of Human Medicine, Radiology, Grand Rapids, MI (United States); Advanced Radiology Services, Grand Rapids, MI (United States)

    2011-10-15

    MRI is frequently utilized to evaluate patients for osteomyelitis. The findings of intramedullary and extramedullary fat globules as well as extramedullary fat-fluid levels can help improve the specificity of MRI for this diagnosis. To correlate these MRI findings with the clinical characteristics in children with osteomyelitis. A retrospective electronic medical record search for pediatric patient charts from March 2004 to November 2009 that contained the word ''osteomyelitis'' in the ''principal diagnosis'' portion of the international classification of disease (ICD) billing code. Each electronic chart was reviewed. MRI examinations of selected children were reviewed by a pediatric radiologist, a general radiologist and a transitional year resident. A total of 10 patients/11 MRI studies were included. Five of the 11 had the MRI finding of extramedullary globular fat signal. There was a significantly increased likelihood of seeing this finding in children of pubertal or postpubertal age compared to those of prepubertal age (p < 0.05). This study provides evidence that the MRI finding of extramedullary fat globules in children with acute osteomyelitis is associated with the clinical characteristic of being within or above the age range for puberty. (orig.)

  5. Clinical, physical and lifestyle indicators and relationship with cognition and mood in aging: a cross-sectional analysis of distinct educational groups

    Directory of Open Access Journals (Sweden)

    Nadine Correia Santos

    2014-02-01

    Full Text Available It is relevant to unravel the factors that may mediate the cognitive decline observed during aging. Previous reports indicate that education has a positive influence on cognitive performance, while age, female gender and, especially, depressed mood were associated with poorer performances across multiple cognitive dimensions (memory and general executive function. Herein, the present study aimed to characterize the cognitive performance of community-dwelling individuals within distinct educational groups categorized by the number of completed formal school years: less than 4, 4, completed primary education, and more than 4. Participants (n = 1051 were randomly selected from local health registries and representative of the Portuguese population for age and gender. Neurocognitive and clinical assessments were conducted in local health care centers. Structural equation modeling was used to derive a cognitive score, and hierarchical linear regressions were conducted for each educational group. Education, age and depressed mood were significant variables in directly explaining the obtained cognitive score, while gender was found to be an indirect variable. In all educational groups, mood was the most significant factor with effect on cognitive performance. Specifically, a depressed mood led to lower cognitive performance. The clinical disease indices cardiac and stroke associated with a more negative mood, while moderate increases in BMI, alcohol consumption and physical activity associated positively with improved mood and thus benefitted cognitive performance. Results warrant further research on the cause-effect (longitudinal relationship between clinical indices of disease and risk factors and mood and cognition throughout aging.

  6. Analysis of the relationship between occlusal and clinical parameters and the need for incisor reduction in confined horses - a retrospective study

    Directory of Open Access Journals (Sweden)

    Luiz Fernando Rapp de Oliveira Pimentel

    2014-11-01

    Full Text Available The purpose of this retrospective study was to evaluate the relationship between occlusal and clinical parameters and the need for incisor shortening in horses. It was based on the retrospective analysis of the dental charts of 75 confined horses. Body condition score, shape of incisors, presence of dysmastication, excursion to molar contact (EMC distance before and after cheek teeth occlusal adjustment were evaluated. History of difficult to riding, dysmastication and digestive problems was also considered. The initial measurement of lateral excursion to molar contact (EMC revealed incisor occlusal surface abnormalities in 45 (60% horses and long incisors (EMC>15mm in five (6.6% horses. Considering clinical examination and history data the need for reduction of incisor length was significant when EMC exceeded 15mm (P<0.0001 and when based on dental shape, clinical history of dysmastication and/or digestive problems or body condition score was also significant (P<0.05. In confined horses, the decision to shorten and align the incisor teeth should be based on observation and history of dysmastication and digestive problems, body condition score, incisors shape and EMC distance. The need for incisor reduction should be determined before dental intervention and reassessed following cheek teeth oclusal adjustment

  7. Relationship of Clinical and Pathologic Nodal Staging in Locally Advanced Breast Cancer: Current Controversies in Daily Practice?

    Science.gov (United States)

    De Felice, Francesca; Musio, Daniela; Bulzonetti, Nadia; Raffetto, Nicola; Tombolini, Vincenzo

    2014-01-01

    Systemic neo-adjuvant therapy plays a primary role in the management of locally advanced breast cancer. Without having any negative effect in overall survival, induction chemotherapy potentially assures a surgery approach in unresectable disease or a conservative treatment in technically resectable disease and acts on a well-vascularized tumor bed, without the modifications induced by surgery. A specific issue has a central function in the neo-adjuvant setting: lymph nodes status. It still represents one of the strongest predictors of long-term prognosis in breast cancer. The discussion of regional radiation therapy should be a matter of debate, especially in a pathological complete response. Currently, the indication for radiotherapy is based on the clinical stage before the surgery, even for the irradiation of the loco-regional lymph nodes. Regardless of pathological down-staging, radiation therapy is accepted as standard adjuvant treatment in locally advanced breast cancer. PMID:25247013

  8. The Relationship of Clinical, Cognitive and Social Measures in Schizophrenia: A Preliminary Finding Combining Measures in Probands and Relatives

    Science.gov (United States)

    Huepe, David; Riveros, Rodrigo; Manes, Facundo; Couto, Blas; Hurtado, Esteban; Cetkovich, Marcelo; Escobar, Maria; Vergara, Viviana; Parrao, Teresa; Ibañez, Agustin

    2012-01-01

    This study examines performance of schizophrenia patients, unaffected relatives and controls in social cognition, cognitive and psychiatric scales looking for possible markers of vulnerability in schizophrenia. Performance of schizophrenia patients from multiplex families, first-degree relatives, and matched controls was compared and, subsequently, discriminant analysis method was used for identifying the best predictors for group membership. By using Multigroup Discriminant Analyses on the three groups, the best predictors were PANSS, Premorbid Adjustment Scale, Faux Pas test, and a face/emotion categorizing task. This model obtained 82% correct global classification, suggesting that the combination of psychiatric scales and neuropsychological/social cognition tesks are the best approach for characterizing this disease. Although preliminary, our results suggest that social cognition tasks are robust markers of schizophrenia family impairments, and that combining clinical, social and neuropsychological measures is the best approach to asses patients and relatives vulnerability. PMID:22425724

  9. The Relationship of Clinical, Cognitive and Social Measures in Schizophrenia: A Preliminary Finding Combining Measures in Probands and Relatives

    Directory of Open Access Journals (Sweden)

    David Huepe

    2012-01-01

    Full Text Available This study examines performance of schizophrenia patients, unaffected relatives and controls in social cognition, cognitive and psychiatric scales looking for possible markers of vulnerability in schizophrenia. Performance of schizophrenia patients from multiplex families, first-degree relatives, and matched controls was compared and, subsequently, discriminant analysis method was used for identifying the best predictors for group membership. By using Multigroup Discriminant Analyses on the three groups, the best predictors were PANSS, Premorbid Adjustment Scale, Faux Pas test, and a face/emotion categorizing task. This model obtained 82% correct global classification, suggesting that the combination of psychiatric scales and neuropsychological/social cognition tesks are the best approach for characterizing this disease. Although preliminary, our results suggest that social cognition tasks are robust markers of schizophrenia family impairments, and that combining clinical, social and neuropsychological measures is the best approach to asses patients and relatives vulnerability.

  10. Evidence showing the relationship between sagittal balance and clinical outcomes in surgical treatment of degenerative spinal diseases: a literature review.

    Science.gov (United States)

    Le Huec, Jean-Charles; Faundez, Antonio; Dominguez, Dennis; Hoffmeyer, Pierre; Aunoble, Stéphane

    2015-01-01

    The measure of radiographic pelvic and spinal parameters for sagittal balance analysis has gained importance in reconstructive surgery of the spine and particularly in degenerative spinal diseases (DSD). Fusion in the lumbar spine may result in loss of lumbar lordosis (LL), with possible compensatory mechanisms: decreased sacral slope (SS), increased pelvic tilt (PT) and decreased thoracic kyphosis (TK). An increase in PT after surgery is correlated with postoperative back pain. A decreased SS and/or abnormal sagittal vertical axis (SVA) after fusion have a higher risk of adjacent segment degeneration. High pelvic incidence (PI) increases the risk of sagittal imbalance after spine fusion and is a predictive factor for degenerative spondylolisthesis. Restoration of a normal PT after surgery is correlated with good clinical outcome. Therefore, there is a need for comparative prospective studies that include pre- and postoperative spinopelvic parameters and compare complication rate, degree of disability, pain and quality of life.

  11. Methamphetamine-Associated Congestive Heart Failure: Increasing Prevalence and Relationship of Clinical Outcomes to Continued Use or Abstinence.

    Science.gov (United States)

    Sliman, Sean; Waalen, Jill; Shaw, David

    2016-10-01

    The purpose of this study was to determine the prevalence of methamphetamine-associated congestive heart failure (MAC) and to evaluate the relationship between methamphetamine abuse and EF and functional status over time. A retrospective review of records from 2009 to 2014 was carried out. Prevalence of methamphetamine abuse among all patients admitted with CHF was calculated for each of the 6 years of the study (n = 141) and was compared with prevalence of cocaine abuse and alcohol abuse. For patients with two or more admissions during the entire time period, the trajectories of NYHA functional class and EF over time were determined (n = 58). MAC has significantly increased from 1.8 to 5.6 % of total CHF patients admitted (n = 3705). Among patients who stopped using methamphetamine, NYHA functional class significantly improved, while among patients who continued methamphetamine use, NYHA was significantly worsened (p < 0.001). Significantly more patients with improved EF stopped using methamphetamine than continued (p = 0.05). There was a significant increase in the prevalence of MAC during the study period for all CHF patients admitted in our hospital system. Continued methamphetamine use is associated with worsening functional status, while cessation of methamphetamine is associated with improvement in functional status.

  12. Pharmacokinetic-pharmacodynamic relationship of anesthetic drugs: from modeling to clinical use [version 1; referees: 4 approved

    Directory of Open Access Journals (Sweden)

    Valerie Billard

    2015-11-01

    Full Text Available Anesthesia is a combination of unconsciousness, amnesia, and analgesia, expressed in sleeping patients by limited reaction to noxious stimulations. It is achieved by several classes of drugs, acting mainly on central nervous system. Compared to other therapeutic families, the anesthetic drugs, administered by intravenous or pulmonary route, are quickly distributed in the blood and induce in a few minutes effects that are fully reversible within minutes or hours. These effects change in parallel with the concentration of the drug, and the concentration time course of the drug follows with a reasonable precision mathematical models based on the Fick principle. Therefore, understanding concentration time course allows adjusting the dosing delivery scheme in order to control the effects.   The purpose of this short review is to describe the basis of pharmacokinetics and modeling, the concentration-effects relationship, and drug interactions modeling to offer to anesthesiologists and non-anesthesiologists an overview of the rules to follow to optimize anesthetic drug delivery.

  13. A review of morphine and morphine-6-glucuronide's pharmacokinetic-pharmacodynamic relationships in experimental and clinical pain.

    Science.gov (United States)

    Sverrisdóttir, Eva; Lund, Trine Meldgaard; Olesen, Anne Estrup; Drewes, Asbjørn Mohr; Christrup, Lona Louring; Kreilgaard, Mads

    2015-07-10

    Morphine is a widely used opioid for treatment of moderate to severe pain, but large interindividual variability in patient response and no clear guidance on how to optimise morphine dosage regimen complicates treatment strategy for clinicians. Population pharmacokinetic-pharmacodynamic models can be used to quantify dose-response relationships for the population as well as interindividual and interoccasion variability. Additionally, relevant covariates for population subgroups that deviate from the typical population can be identified and help clinicians in dose optimisation. This review provides a detailed overview of the published human population pharmacokinetic-pharmacodynamic studies for morphine analgesia in addition to basic drug disposition and pharmacological properties of morphine and its analgesic active metabolite, morphine-6-glucuronide, that may help identify future covariates. Furthermore, based on simulations from key pharmacokinetic-pharmacodynamic models, the contribution of morphine-6-glucuronide to the analgesic response in patients with renal insufficiency was investigated. Simulations were also used to examine the impact of effect-site equilibration half-life on time course of response. Lastly, the impact of study design on the likelihood of determining accurate pharmacodynamic parameters for morphine response was evaluated.

  14. Clinical significance of telomerase activity in peritoneal lavage fluid from patients with gastric cancer and its relationship with cellular proliferation

    Institute of Scientific and Technical Information of China (English)

    Ming-Xu Da; Xiao-Ting Wu; Tian-Kang Guo; Zi-Guang Zhao; Ting Luo; Kun Qian; Ming-Ming Zhang; Jie Wang

    2007-01-01

    AIM: To evaluate the efficacy of telomerase activity assay and peritoneal lavage cytology (PLC) examination in peritoneal lavage fluid for the prediction of peritoneal metastasis in gastric cancer patients, and to explore the relationship between telomerase activity and proliferating cell nuclear antigen expression.METHODS: Telomeric repeated amplification protocol (TRAP)-enzyme-linked immunosorbent assay (ELISA) was performed to measure the telomerase activity in 60 patients with gastric cancer and 50 with peptic ulcer. PLC analysis of the 60 patients with gastric cancer was used for comparison. The proliferating cell nuclear antigen (PCNA) in gastric carcinoma was immunohistochemically examined.RESULTS: The telomerase activity and PLC positive rate in peritoneal lavage fluid from patients with gastric cancer was 41.7% (25/60), and 25.0% (15/60), respectively. The positive rate of telomerase activity was significantly higher than that of PLC in the group Of pT4 (15/16 vs 9/16, P < 0.05), P1-3 (13/13 vs 9/13, P < 0.05) and diffuse type (22/42 vs 13/42, P < 0.05). The patients with positive telomerase activity, peritoneal metastasis, and serosal invasion had significantly higher levels of average PCNA proliferation index (PI), (55.00 ± 6.59 vs 27.43 ± 7.72, 57.26 ± 10.18 vs 29.15 ± 8.31, and 49.82 ± 6.74 vs 24;65 ± 7.33, respectively, P < 0.05).CONCLUSION: The TRAP assay for telomerase activity is a useful adjunct for cytologic method in the diagnosis of peritoneal micrometastasis and well related to higher proliferating activity of gastric cancer. The results of this study also suggest a promising future therapeutic strategy for treating peritoneal dissemination based on telomerase inhibition.

  15. Mast cells and acute coronary syndromes: relationship between serum tryptase, clinical outcome and severity of coronary artery disease

    Science.gov (United States)

    Morici, Nuccia; Farioli, Laura; Losappio, Laura Michelina; Colombo, Giulia; Nichelatti, Michele; Preziosi, Donatella; Micarelli, Gianluigi; Oliva, Fabrizio; Giannattasio, Cristina; Klugmann, Silvio; Pastorello, Elide Anna

    2016-01-01

    Objective To assess the relationship between serum tryptase and the occurrence of major cardiovascular and cerebrovascular events (MACCE) at 2-year follow-up in patients admitted with acute coronary syndrome (ACS). To compare serum tryptase to other validated prognostic markers (maximum high-sensitivity troponin (hs-Tn), C reactive protein (CRP) levels at admission, Synergy between percutaneous coronary intervention with Taxus and Cardiac Surgery (SYNTAX) score). Methods We measured serum tryptase at admission in 140 consecutive patients with ACS and in 50 healthy controls. The patients’ follow-up was maintained for 2 years after discharge. The predictive accuracy of serum tryptase for 2-year MACCE was assessed and compared with hs-Tn, CRP and SYNTAX score. Results Serum tryptase levels at admission were significantly higher in patients with ACS compared with the control group (p=0.0351). 2 years after discharge, 28/140 patients (20%) experienced MACCE. Serum tryptase levels, maximum hs-Tn measurements and SYNTAX score were higher in patients who experienced MACCE compared with those without (p<0.0001). Conversely, we found no significant association between MACCE and CRP. The predictive accuracy of serum tryptase for MACCE was set at the cut-off point of 6.7 ng/mL (sensitivity 46%, specificity 84%). Conclusions In patients with ACS, serum tryptase measured during index admission is significantly correlated to the development of MACCE up to 2 years, demonstrating a possible long-term prognostic role of this biomarker. PMID:27752333

  16. The relationship between serum antioxidant vitamins, magnesium levels, and clinical parameters in patients with primary fibromyalgia syndrome.

    Science.gov (United States)

    Sakarya, Sukran Tastan; Akyol, Yesim; Bedir, Abdulkerim; Canturk, Ferhan

    2011-08-01

    We proposed to assess serum antioxidant vitamins and magnesium (Mg) levels in patients with fibromyalgia (FM) in comparison to healthy controls. Additionally, the association between the serum antioxidant vitamins, magnesium levels, and clinical parameters in FM patients was also investigated. Forty female patients, aged between 30 and 50 years, were diagnosed with FM according to ACR-1990 criteria, and 40 healthy controls were included in the present study. Socio-demographic characteristics of participants, accompanying symptoms, and number of tender points (TP) of the patients were recorded. The intensity of pain was measured using the visual analogue scale (VAS). The functional status and depression levels were evaluated with Fibromyalgia Impact Questionnaire (FIQ) and Beck Depression Inventory (BDI), respectively. Serum vitamins A, C, and E and Mg levels were measured. There were no significant differences in the levels of vitamins A, C, and E and Mg between control subjects and patients with fibromyalgia (p > 0.05). In addition, no statistically significant correlations were found between mean levels of serum vitamins A, C, and E, and Mg and number of TP, scores of VAS, FIQ, and BDI in patients with FM (p > 0.05). According to the results of this study, it was asserted that other complex mechanism may play an important role in the pathophysiology of FM without plasma antioxidant vitamins and Mg levels.

  17. Designing Objective Structured Clinical Examination in Basic Community Pharmacy Clerkship Course and Assessment of Its Relationship with Conventional Exam

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    Leila Kouti

    2015-10-01

    Full Text Available Background: Over 90% of pharmacy students’ work in pharmacies after graduation which needs both knowledge and skill, thus one of the most essential courses of their education is pharmacy clerkship. An important part of an educational program is the evaluation of the trainees. Different studies show that conventional written exams are not successful in evaluating the skills of the students and can mostly evaluate their knowledge. Thus Objective Structured Clinical Examination (OSCE is used to evaluate the students in different aspects.Methods: An OSCE and a conventional test were given to a group of students at the end of basic community pharmacy clerkship course. The OSCE test consisted of six different stations (reading prescriptions, identifying drugs, pharmacist’s recommendation, patient education, drug information resources, and drug usage instructions. Two questions were asked at each station by different examiners. The scores and results of these tests were compared and analyzed.Results: There was no significant correlation between OSCE final scores and written test scores (P: = 0.217. No significant correlation between each station’s score and the written test score was found.Conclusion: The absence of significant correlation between OSCE and conventional exams shows that the skills evaluated by OSCE cannot be evaluated by the best possible written tests. This type of examination is not commonly used in Iran’s pharmacy schools but due to the findings of this study, it seems that this multiform method, despite being more difficult to arrange, can be a more suitable and relevant way to evaluate basic community pharmacy clerkship compared to conventional written tests.

  18. Relationship between time to positivity of blood culture with clinical characteristics and hospital mortality in patients with Escherichia coli bacteremia

    Institute of Scientific and Technical Information of China (English)

    BO Shi-ning; BO Jian; NING Yong-zhong; ZHAO Yu; LU Xiao-lin; YANG Ji-yong; ZHU Xi; YAO Gai-qi

    2011-01-01

    Background Previous studies indicated that the time to positivity (TTP) of blood culture is a parameter correlating with degree of the bacteremia and outcome in patients with bloodstream infections caused by Escherichia coli (E.co/i). The objective of this study was to further investigate the diagnostic and prognostic power of using TTP to predict E. coli bacteremia.Methods A retrospective cohort study at two university hospitals was conducted. We retrieved all the medical records of those with E. coli bloodstream infection according to the records generated by their microbiology departments.Univariate and multivariate analyses were applied to identify clinical factors correlating with fast bacterial growth and significant prognostic factors for hospital mortality.Results Medical records of 353 episodes of E. coli bacteremia diagnosed between January 1,2007 and December 31,2009 were retrieved in the investigation. Univariate analysis demonstrated that the TTP≤7 hours group is associated with higher incidence of active malignancies (41.7% vs. 27.2%, P=0.010), neutropenia (30% vs.14.3%, P=0.007), primary bacteremia (55.0% vs. 33.4%, P=0.002), and poorer outcome (hospital mortality 43.3% vs.11.9%, P=0.000) than the TTP >7 hours group. Multivariate analysis revealed that the significant predictors of hospital mortality, in rank order from high to low, were TTP (for TTP <7 hours, odds ratio (OR): 4.886; 95% confidence interval (CI): 2.572-9.283; P=0.000),neutropenia (OR: 2.800; 95% CI:1.428-5.490; P=0.003), comedication of steroids or immunosuppressive agents (OR:2.670; 95% CI: 0.971-7.342; P=0.057).Conclusions Incidence of malignancies, neutropenia and primary bacterernia correlates with fast bacterial growth in patients with E. coli bacteremia. The parameter of TTP has been identified as a variable of highest correlation to hospital mortality and therefore can be potentially utilized as a mortality prognostic marker.

  19. Relationship of Albuminuria and Renal Artery Stent Outcomes: Results From the CORAL Randomized Clinical Trial (Cardiovascular Outcomes With Renal Artery Lesions).

    Science.gov (United States)

    Murphy, Timothy P; Cooper, Christopher J; Pencina, Karol M; D'Agostino, Ralph; Massaro, Joseph; Cutlip, Donald E; Jamerson, Kenneth; Matsumoto, Alan H; Henrich, William; Shapiro, Joseph I; Tuttle, Katherine R; Cohen, David J; Steffes, Michael; Gao, Qi; Metzger, D Christopher; Abernethy, William B; Textor, Stephen C; Briguglio, John; Hirsch, Alan T; Tobe, Sheldon; Dworkin, Lance D

    2016-11-01

    Randomized clinical trials have not shown an additional clinical benefit of renal artery stent placement over optimal medical therapy alone. However, studies of renal artery stent placement have not examined the relationship of albuminuria and treatment group outcomes. The CORAL study (Cardiovascular Outcomes in Renal Atherosclerotic Lesions) is a prospective clinical trial of 947 participants with atherosclerotic renal artery stenosis randomized to optimal medical therapy with or without renal artery stent which showed no treatment differences (3(5.8% and 35.1% event rate at mean 43-month follow-up). In a post hoc analysis, the study population was stratified by the median baseline urine albumin/creatinine ratio (n=826) and analyzed for the 5-year incidence of the primary end point (myocardial infarction, hospitalization for congestive heart failure, stroke, renal replacement therapy, progressive renal insufficiency, or cardiovascular disease- or kidney disease-related death), for each component of the primary end point, and overall survival. When baseline urine albumin/creatinine ratio was ≤ median (22.5 mg/g, n=413), renal artery stenting was associated with significantly better event-free survival from the primary composite end point (73% versus 59% at 5 years; P=0.02), cardiovascular disease-related death (93% versus 85%; P≤ 0.01), progressive renal insufficiency (91% versus 77%; P=0.03), and overall survival (89% versus 76%; P≤0.01), but not when baseline urine albumin/creatinine ratio was greater than median (n=413). These data suggest that low albuminuria may indicate a potentially large subgroup of those with renal artery stenosis that could experience improved event-free and overall-survival after renal artery stent placement plus optimal medical therapy compared with optimal medical therapy alone. Further research is needed to confirm these preliminary observations.

  20. Virus-specific immune response in HBeAg-negative chronic hepatitis B: relationship with clinical profile and HBsAg serum levels.

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    Elisabetta Loggi

    Full Text Available BACKGROUND AIMS: The immune impairment characterizing chronic hepatitis B (cHBV infection is thought to be the consequence of persistent exposure to viral antigens. However, the immune correlates of different clinical stages of cHBV and their relation with different levels of HBsAg have not been investigated. The aim of the present study was to evaluate the relationship between HBV-specific T cells response and the degree of in vivo HBV control and HBsAg serum levels in HBeAg-HBeAb+ cHBV. METHODS: Peripheral blood mononuclear cells from 42 patients with different clinical profiles (treatment-suppressed, inactive carriers and active hepatitis of cHBV, 6 patients with resolved HBV infection and 10 HBV-uninfected individuals were tested with overlapping peptides spanning the entire HBV proteome. The frequency and magnitude of HBV-specific T cell responses was assessed by IFNγ ELISPOT assay. Serum HBsAg was quantified with a chemiluminescent immunoassay. RESULTS: The total breadth and magnitude of HBV-specific T cell responses did not differ significantly between the four groups. However, inactive carriers targeted preferentially the core region. In untreated patients, the breadth of the anti-core specific T cell response was inversely correlated with serum HBsAg concentrations as well as HBV-DNA and ALT levels and was significantly different in patients with HBsAg levels either above or below 1000 IU/mL. The same inverse association between anti-core T cell response and HBsAg levels was found in treated patients. CONCLUSIONS: Different clinical outcomes of cHBV infection are associated with the magnitude, breadth and specificity of the HBV-specific T cell response. Especially, robust anti-core T cell responses were found in the presence of reduced HBsAg serum levels, suggesting that core-specific T cell responses can mediate a protective effect on HBV control.

  1. Relationship between urinary albumin excretion rate and renal histology in non-insulin-dependent diabetes mellitus: with reference to the clinical significance of microalbuminuria.

    Science.gov (United States)

    Inomata, S; Nakamoto, Y; Inoue, M; Itoh, M; Ohsawa, Y; Masamune, O

    1989-01-01

    The present study demonstrates the relationship between urinary albumin excretion rate (AER) and renal structural changes in patients with non-insulin-dependent diabetes mellitus (NIDDM) without clinical proteinuria. Resting AER in 30 control subjects and 67 NIDDM patients were 10.4 +/- 4.8 (mean +/- SD) micrograms/min (range 4.3-21.1 micrograms/min) and 26.4 +/- 32.3 micrograms/min (range 0.4-155 micrograms/min), respectively. Persistent normoalbuminuria (less than 20 micrograms/min) and microalbuminuria (20-200 micrograms/min) were found in 43 (Group A) and 24 (Group B) diabetics. There were significant differences in age, diabetes duration, and frequency of retinopathy (background and proliferative) as well as that of proliferative retinopathy between Groups A and B, but not in the other clinical parameters such as body mass index, HbA1, Ccr, or systolic and diastolic blood pressure (SBP, DBP). When compared with 11 normoalbuminuric patients of similar age and equal diabetes duration to those in Group B, the sole difference in clinical parameters was the existence of proliferative retinopathy in Group B. Renal structural changes were investigated by light microscopy in 14 people in Group A and 13 people in Group B, and additionally in 5 NIDDM patients with both macroalbuminuria (greater than or equal to 200 micrograms/min) and normal or nearly normal renal function (Group C). The diffuse glomerular lesion (Gellman's classification) was grade I or II in A, II or III in B, and III in C.(ABSTRACT TRUNCATED AT 250 WORDS)

  2. Craving for Food in Virtual Reality Scenarios in Non-Clinical Sample: Analysis of its Relationship with Body Mass Index and Eating Disorder Symptoms.

    Science.gov (United States)

    Ferrer-Garcia, Marta; Gutierrez-Maldonado, Jose; Treasure, Janet; Vilalta-Abella, Ferran

    2015-09-01

    Virtual reality (VR) technology has been successfully used to study the influence of specific and contextual food-related cues on emotional, cognitive and behavioural responses in patients with eating disorders (ED) and healthy controls. Following this research line, the present study assesses the effect on reported food craving of the type of food (low calorie versus high calorie) and the presence or absence of other people (private versus social context) in VR environments. Relationships between craving and body mass index (BMI) and ED symptoms are also explored. Eighty-seven female students were exposed to four VR scenarios presented in random order: a low-calorie kitchen, a high-calorie kitchen, a low-calorie restaurant and a high-calorie restaurant. After 2 minutes of exposure to each virtual scenario, food craving was assessed. Repeated measures analyses of covariance were conducted to assess changes in food craving following exposure to the different VR environments. Time elapsed since the last meal was introduced as a covariate to control for responses produced by food deprivation. Correlation and hierarchical multiple regression analyses were also conducted to assess the relationship between reported food craving and BMI and ED symptoms. Participants experienced higher levels of food craving after exposure to high-calorie foods (in both the kitchen and restaurant environments) than after exposure to low-calorie foods. Being alone in the kitchen or with friends in the restaurant had no effect on reported craving. Overall, neither BMI nor ED symptoms were related with reported food craving; only in the restaurant with low-calorie food was a significant negative correlation found between BMI and food craving. The results suggest that cue exposure in virtual environments is an effective procedure for inducing food craving in healthy controls and may be useful as a research and therapeutic tool in clinical populations.

  3. Relationship analysis between clinical factor and prognosis of prostate cancer%前列腺癌临床各因素与预后的关系分析

    Institute of Scientific and Technical Information of China (English)

    窦建国; 王德林

    2011-01-01

    目的 探讨前列腺癌(PCa)患者年龄、前列腺特异性抗原密度(PSAD)、Gleason评分、临床分期、骨转移等临床因素与其预后的关系.方法 回顾分析2005年6月至2009年1月病检确诊为前列腺癌,有完整前列腺特异性抗原(PSA)及发射单电子计算机断层扫描(ECT)、CT/MRI、X线和B超检查资料,能够准确进行TNM分期及计算PSAD的57例患者.结果 年龄与临床分期(T)呈正相关(r=0.287,P0.05).死亡组与非死亡组比较,骨转移、T、PSAD及Gleason评分差异均有统计学意义(P3 ng·mL-1·(cm3)-1组累积生存率比小于或等于3 ng·mL-1·(cm3)-1组明显降低(P<0.05),PSAD对判断PCa患者预后可能具有一定作用.%Objective To study the relationships between prognosis of patients with prostate cancer( PCa) and age , PSAD, Gleason score, clinical stage and bone metastasis. Methods Clinical data of fifty seven PCa patients was reviewed, who were diagnosed by pathological examination in our hospital between June. 2005 and Jan. 2009, and had complete informations of PSA, ECT, CT/MRI,X ray, B-Ultrasound of prostate,TNM stage and PSAD. Results Age was positively correlated with clinical stage(T) (r =0. 287 ,P<0. 01) , and PSAD was positively correlated with T(r= 0. 321 , P<0. 01) and Gleason score( r= 0. 327 , P < 0. 01). T was positively correlated with Gleason score(r= 0. 250, P<0. 01). Age was not significantly correlated with Gleason score(P> 0. 05). Between death group and non-death group,bone metastasis, clinical stage,PSAD and Gleason score were significantly different(P<0. 05). With Gleason score 7 as a cutoff point,there was a significantly different mortality between >7 group and≤7 group (P<0. 05). With PSAD level 3 ng · mL-1 · (cm3 ) -1 as a cutoff point,there was also a significant different mortality rates between PSAD ≤3 ng · mL-1 · (cm3 )-1 group and >3 ng · mL-1 · (cm3 )-1 group(P<0. 01). 1 , 2 , 3 , 4-year cumulative survival rates

  4. The relationship between Interleukin 18 expression in laryngeal squamous cell carcinoma and clinical pathology as well as the effect of cetuximab on its expression

    Institute of Scientific and Technical Information of China (English)

    Xiu-Ping Liao; Nian Lyu; Sen-Lan Long

    2015-01-01

    Objective:To explore the relationship between Interleukin 18 (IL-18) expression in laryngeal squamous cell carcinoma and clinical pathology as well as the effect of cetuximab on its expression.Methods:40 cases of patients with laryngeal squamous cell carcinoma from January 2010 to June 2014 were chosen as the research group; 40 cases of patients with vocal cord polyp and 40 healthy volunteers were chosen as the control group. Statistical analysis was carried out on clinical pathology of laryngeal squamous cell carcinoma. IL-18, IFN-γ, TNF-αand IL-6 levels in peripheral blood mononuclear cells before and after cetuximab application were detected.Results:Detected IL-18 values of laryngeal squamous cell carcinoma group were higher than those of adjacent cancer tissue and vocal cord polyps; IL-18 positive rate (75.0%) of laryngeal squamous cell carcinoma group was higher than that of adjacent cancer tissue (47.5%) and polyp tissue (37.5%); IL-18 expressions of laryngeal squamous cell carcinoma group were related to primary lesion staging, differentiation degree and lymph node metastasis; before cetuximab application, IL-18 levels were significantly higher than those of the control group, and after cetuximab application, IL-18 levels significantly decreased than before. Differences were statistically significant; after cetuximab application, IFN-γ, TNF-αand IL-6 levels in PBMCs supernatant of patients with laryngeal squamous cell carcinoma were significantly lower than before. Differences were statistically significant.Conclusion:IL-18 can be highly expressed in laryngeal squamous cell carcinoma; IL-18 expression is involved in the occurrence and progress of laryngeal squamous cell carcinoma; IL-18 is possible to be involved in the occurrence and progress of laryngeal squamous cell carcinoma through regulating expressions of IFN-γ, TNF-α and IL-6, etc; IL-18 can be used as a target of laryngeal squamous cell carcinoma treatment, and cetuximab can inhibit IL-18

  5. Relationship between nasolaryngoscopic findings and pH probe esophageal monitoring in children with clinical manifestations of extra-esophageal reflux

    Directory of Open Access Journals (Sweden)

    Oliveira, Neide Fatima Cordeiro Diniz

    2009-06-01

    Full Text Available Introduction: The gastroesophageal reflux diagnosis, mainly in patients with atypical manifestations, has been receiving increasing importance. Objective: To relate the nasolaryngoscopic findings with prolonged pH probe esophageal monitoring in children with clinical manifestations of extra-esophageal reflux. Method: Transversal prospective clinical study, in which we evaluated 44 children from one to 12 years old, of both genders, by means of nasolaryngoscopy. All were submitted to pH probe monitoring for research of hidden reflux due to cases of otitis, sinusitis, asthma, laryngitis and/or dysphonia in the last 12 months. Results: Out of 44 children, 15 (34% presented with normal pH monitoring and 29 (66% with altered monitoring. Out of 29 with altered pH monitoring, 19 (65.5% were boys and 10 (34.5% were girls. There was no statistically significant difference between gender and the positive results of pH monitoring, in spite of a discreet predominance of occurrence in the male population. All children had smaller adenoids than 75% of the cavity of concha aerial column. Six presented with purulent secretion in nasal cavity. Eight (18% had nodes in vocal cords and five (11% of whom had an altered pH monitoring and three (7% of whom were normal. We found at least one alteration upon nasolaryngoscopy in 80% of the 15 children with normal pH monitoring and in 89.7% of the 29 who had an altered pH monitoring. Conclusion: The prevalence of gastroesophageal reflux in children with recurrent respiratory and otorhinolaryngological affections was high. However, the data obtained didn't show any statistically significant difference (p<0.05 among the nasolaryngoscopic findings, associated or not with gastroesophageal reflux, confirmed by pH monitoring. Therefore, no relationship was found between the pathological gastric acid reflux and nasolaryngoscopic alterations.

  6. The relationship between cognitive impairment and in vivo metabolite ratios in patients with clinical Alzheimer's disease and vascular dementia: a proton magnetic resonance spectroscopy study

    Energy Technology Data Exchange (ETDEWEB)

    Waldman, A.D. [Department of Imaging, Charing Cross Hospital and Dementia Research Group, University College London, Fulham Palace Road, W6 8RF, London (United Kingdom); Rai, G.S. [Department of Care of Older People, Whittington Hospital, Highgate Hill, London (United Kingdom)

    2003-08-01

    Previous magnetic resonance spectroscopy (MRS) studies have shown increased myo-inositol (MI) and decreased N-acetyl aspartate (NAA) levels in the parieto-occipital lobes of patients with Alzheimer's disease (AD) compared to those with other dementias and normal subjects. This study aimed to establish the quantitative relationship between metabolite ratios and degree of cognitive impairment in patients with mild to moderate AD and sub-cortical ischaemic vascular dementia (SIVD). Forty-four older people with clinical dementia were recruited from a memory clinic and followed up for 2.0-3.5 years; 20 cases were finally classified as probable AD, 18 as SIVD and 6 as mixed type. Mini Mental State Examination (MMSE) and short echo time single voxel automated MRS from the mesial parieto-occipital lobes were performed at the time of initial referral. Spearman rank correlation coefficients were calculated for MMSE scores and measured metabolite ratios MI/Cr, NAA/Cr, Cho/Cr and NAA/MI. The AD group showed a significant correlation between MMSE and NAA/MI (r=0.54, P=0.014) and NAA/Cr (r=0.48, P=0.033), and a negative, non-significant association with MI/Cr (r=-0.41, P=0.072). MI/Cr was negatively correlated with NAA/Cr (r=-0.51, P=0.021). Neither Cho/Cr ratios nor age correlated with cognitive function. The SIVD group showed no correlation between any of the measured metabolite ratios and MMSE score. This study reinforces the specific association between reduced NAA and increased MI levels in the parieto-occipital region and cognitive impairment in AD. MRS may have a role in evaluating disease progression and therapeutic monitoring in AD, as new treatments become available. (orig.)

  7. Relationships between PON1 Q192R polymorphism and clinical outcome of antiplatelet treatment after percutaneous coronary intervention: a meta-analysis.

    Science.gov (United States)

    Li, Ping; Bu, Shu-Hong; Lu, Xiao-Tong; Li, Li-Xia; Xu, A-Jing; Tang, Yue-Nian; Zhang, Jian

    2014-09-01

    This meta-analysis was performed to assess the relationships between the PON1 Q192R (rs662 T>C) polymorphism and the clinical outcome of antiplatelet treatment after percutaneous coronary intervention (PCI). A range of electronic databases were searched: Web of Science (1945-2013), the Cochrane Library Database (Issue 12, 2013), PubMed (1966-2013), EMBASE (1980-2013), CINAHL (1982-2013) and the Chinese Biomedical Database (CBM) (1982-2013) without language restrictions. Meta-analysis was conducted using the STATA 12.0 software. The crude odds ratio (OR) with their 95 % confidence interval (CI) were calculated. Six clinical cohort studies with a total number of 5,189 patients undergoing PCI for coronary heart disease were included. Our meta-analysis revealed that the PON1 Q192R polymorphism was correlated with an increased risk of major adverse cardiovascular events (MACE) in patients receiving antiplatelet treatment after PCI (C allele vs. T allele: OR = 1.22, 95 % CI 1.04-1.43, P = 0.014; CT+CC vs. TT: OR = 1.38, 95 % CI 1.03-1.86, P = 0.029; CC vs. TT: OR = 1.45, 95 % CI 1.05-1.99, P = 0.024; respectively), especially among Asians. Furthermore, we found significantly positive correlations between the PON1 Q192R polymorphism and the incidence of stent thrombosis in patients receiving antiplatelet treatment after PCI (C allele vs. T allele: OR = 1.42, 95 % CI 1.08-1.87, P = 0.011; CT+CC vs. TT: OR = 1.93, 95 % CI 1.01-3.67, P = 0.046; CC vs. TT: OR = 2.18, 95 % CI 1.09-4.35, P = 0.027; respectively). Our meta-analysis of clinical cohort studies provides evidence that the PON1 Q192R polymorphism may increase the risk of MACE and stent thrombosis in patients receiving antiplatelet treatment after PCI.

  8. Use of Information and Communication Technologies in Clinical Practice Related to the Treatment of Pain. Influence on the Professional Activity and the Doctor-Patient Relationship.

    Science.gov (United States)

    Fernandez, Jorge Muriel; Cenador, Maria Begoña García; Manuel López Millan, J; Méndez, Juan Antonio Juanes; Ledesma, María José Sánchez

    2017-05-01

    The increasing relevance of Information and Communication Technologies (ICTs) in medical care is indisputable. This evidence makes it necessary to start studies that analyse the scope these new forms of access to information and understanding of medicine have on the professional activity of the physician, on the attitude and on the knowledge of patients or, on the doctor-patient relationship. The purpose of this study is to explore some of these aspects in a group of physicians whose clinical activity is related to one of the greatest social impact health problems which is the treatment of chronic pain. Starting with the completion of a questionnaire, in the study group it is observed that the interaction between social structure, increase of information flows and ICTs generate transformations in social practices and behaviour of the actors of the health system. Internet is confirmed as an information space on the subject, but is shown as an underutilized space of interaction between the doctor and his patient.

  9. The relationship of mucosal bacteria to duodenal histopathology, cytokine mRNA, and clinical disease activity in cats with inflammatory bowel disease.

    Science.gov (United States)

    Janeczko, S; Atwater, D; Bogel, E; Greiter-Wilke, A; Gerold, A; Baumgart, M; Bender, H; McDonough, P L; McDonough, S P; Goldstein, R E; Simpson, K W

    2008-04-01

    Feline inflammatory bowel disease (IBD) is the term applied to a group of poorly understood enteropathies that are considered a consequence of uncontrolled intestinal inflammation in response to a combination of elusive environmental, enteric microbial, and immunoregulatory factors in genetically susceptible cats. The present study sought to examine the relationship of mucosal bacteria to intestinal inflammation and clinical disease activity in cats with inflammatory bowel disease. Duodenal biopsies were collected from 27 cats: 17 undergoing diagnostic investigation of signs of gastrointestinal disease, and 10 healthy controls. Subjective duodenal histopathology ranged from normal (10), through mild (6), moderate (8), and severe (3) IBD. The number and spatial distribution of mucosal bacteria was determined by fluorescence in situ hybridization with probes to 16S rDNA. Mucosal inflammation was evaluated by objective histopathology and cytokine profiles of duodenal biopsies. The number of mucosa-associated Enterobacteriaceae was higher in cats with signs of gastrointestinal disease than healthy cats (Pcats. These data establish that the density and composition of the mucosal flora is related to the presence and severity of intestinal inflammation in cats and suggest that mucosal bacteria are involved in the etiopathogenesis of feline IBD.

  10. Effects of Ascorbic Acid on Serum Level of Unconjugated Estriol and Its Relationship with Preterm Premature Rupture of Membrane: A Double-Blind Randomized Controlled Clinical Trial

    Directory of Open Access Journals (Sweden)

    Mehrangiz Zamani

    2013-09-01

    Full Text Available Background: Vitamin C is a water-soluble antioxidant that not only stimulates and protects collagen synthesis but also plays an important role in maintaining cellular integrity in a normal pregnancy. This study surveyed the effects of ascorbic acid on the serum level of unconjugated estriol and the relationship between unconjugated estriol and preterm premature rupture of membrane (PPROM. Methods: This double-blind, randomized clinical trial recruited 60 patients with predisposing factors to PPROM. The women were randomly divided into two groups of intervention and control and received vitamin C and placebo, respectively. The intervention group received 250 mg vitamin C twice a day and the controls received the placebo only. Unconjugated estriol was measured using the ELISA. All data were extracted and recorded in a checklist and compared using descriptive statistics as well as the x2, Fisher exact, and t tests. Results: The demographic data showed no difference between the two groups. The mean level of serum unconjugated estriol was significantly lower in the intervention group than in the control group (P=0.044. Also, the frequency of PPROM was lower in the intervention group, but the difference was not significant (P>0.05. Unconjugated estriol levels were not significantly different between the healthy women and the PPROM patients. Conclusion: This study demonstrated that vitamin C administration decreased unconjugated estriol levels in the patients with PPROM. The findings of this study also indicated that administration of ascorbic acid was a safe and effective method to reduce the incidence of PPROM. Alteration in unconjugated estriol is an active mediator for this effect. Trial Registration Number: IRCT201012083580N3

  11. 幽门螺杆菌感染与胆汁反流的临床关系%Clinical Relationship between Helicobacter Pylori Infection and Bile Reflux

    Institute of Scientific and Technical Information of China (English)

    宋敏

    2016-01-01

    Objective:To explore the clinical relationship between infection of helicobacter pylori and bile reflux.Method:256 patients underwent gastroscopy in our hospital from January 2014 to June 2014 were selected,according to the results of gastroscopy,they were divided into A group and B group, the patients of A group with bile reflux,while the patients of B group without bile reflux.All patients underwent rapid urease test, and according to the judgement of the detection with Helicobacter pylori infection,positive rate of Helicobacter pylori infection in two groups were compared.Result:There were 28 cases in the A group and the positive rate of helicobacter pylori was 32.1%. However,there were 228 cases in the B group and the positive rate of helicobacter pylori was 67.1%, the difference was statistically significant(P<0.01).Conclusion:The refluent bile can inhibit or kill helicobacter pylori.%目的:探讨幽门螺杆菌感染与胆汁反流的临床关系。方法:选取2014年1-6月于笔者所在医院行胃镜检查的256例患者,根据胃镜检查结果,分为A组、B组,A组患者均存在胆汁反流,B组患者无胆汁反流。所有患者均行快速尿素酶试验检测,并根据其检测结果判定有无幽门螺杆菌感染,比较两组患者幽门螺杆菌感染的阳性率。结果:A组28例,幽门螺杆菌阳性率为32.1%,B组228例,幽门螺杆菌阳性率为67.1%,两组比较差异有统计学意义(P<0.01)。结论:反流的胆汁可能能够抑制或杀灭幽门螺杆菌。

  12. Determining Whether a Definitive Causal Relationship Exists Between Aripiprazole and Tardive Dyskinesia and/or Dystonia in Patients With Major Depressive Disorder, Part 3: Clinical Trial Data.

    Science.gov (United States)

    Preskorn, Sheldon H; Macaluso, Matthew

    2016-03-01

    This series of columns has 3 main goals: (1) to explain class warnings as used by the United States Food and Drug Administration, (2) to increase awareness of movement disorders that may occur in patients treated with antipsychotic medications, and (3) to understand why clinicians should refrain from immediately assuming a diagnosis of tardive dyskinesia/dystonia (TD) in patients who develop abnormal movements during treatment with antipsychotics. The first column in the series presented a patient who developed abnormal movements while being treated with aripiprazole as an augmentation strategy for major depressive disorder (MDD) and reviewed data concerning the historical background, incidence, prevalence, and risk factors for tardive and spontaneous dyskinesias, the clinical presentations of which closely resemble each other. The second column in the series reviewed the unique mechanism of action of aripiprazole and preclinical studies and an early-phase human translational study that suggest a low, if not absent, risk of TD with aripiprazole. This column reviews clinical trial data to assess whether those data support the conclusion that aripiprazole has a low to absent risk of causing TD when used as an augmentation strategy to treat MDD. To date, no randomized, placebo-controlled trials have established a definitive link between exposure to aripiprazole and TD in patients with MDD. One long-term, open-label, safety trial examined aripiprazole as an augmentation strategy in individuals with MDD and found a rare occurrence (4/987, 0.4%, the confidence interval of which overlaps with zero) of an adverse event termed TD. In all 4 cases, the observed movements resolved within weeks of aripiprazole discontinuation, suggesting that they were either amenable to treatment or represented an acute syndrome rather than TD. No cases of TD were reported in the registration trials for the MDD indication for aripiprazole. These data were presented in a pooled analysis of

  13. Relationship of academic courses and clinical internships to performance on the National Qualified Examination for Registered Professional Nurses (NQEX-RPN

    Directory of Open Access Journals (Sweden)

    Huimin Xiao

    2014-12-01

    Conclusion: Surgical-medicine nursing, Community health care, Computer basics and clinical internships are beneficial in assisting students and educators to identify the risk of students' performance in the NQEX-RPN.

  14. Childhood adversity as a moderator of the relationship between emotional reactivity and the occurrence of anxiety and depression in a non-clinical group

    Directory of Open Access Journals (Sweden)

    Wojciech Łukasz Dragan

    2016-02-01

    The obtained results are only partially explained within the temperamental risk factor model. A different pattern of relationships between the intensity of the temperamental trait and the occurrence of anxiety and depression depending on the amount of reported adversity may result from the cumulative effect of the negative consequences of this type of experience.

  15. The Relationship between Intake of Dairy Products and Polycystic Ovary Syndrome in Women Who Referred to Isfahan University of Medical Science Clinics in 2013

    Directory of Open Access Journals (Sweden)

    Golnaz Rajaeieh

    2014-01-01

    Conclusions: The findings of this study indicated that ovarian disease and medication use is directly linked to PCOS. Dairy consumption was not significantly correlated with PCOS. However, after adjustment for confounders, there was an direct relationship between milk consumption and risk of PCOS.

  16. Students' Reflections on the Relationships between Safe Learning Environments, Learning Challenge and Positive Experiences of Learning in a Simulated GP Clinic

    Science.gov (United States)

    Young, J. E.; Williamson, M. I.; Egan, T. G.

    2016-01-01

    Learning environments are a significant determinant of student behaviour, achievement and satisfaction. In this article we use students' reflective essays to identify key features of the learning environment that contributed to positive and transformative learning experiences. We explore the relationships between these features, the students'…

  17. Relationship Between the Clinical Components of the Boder Test of Reading-Spelling Patterns and the Stanford Achievement Test: Validity of the Boder.

    Science.gov (United States)

    Hooper, Stephen R.

    1988-01-01

    Investigated the concurrent validity of the diagnostic components of the Boder Test of Reading-Spelling Patterns with the reading and spelling measures of the Stanford Achievement Reading Test (SAT) in 87 reading-disabled elementary school students. Results indicated the relationship between the reading components of the Boder and SAT were…

  18. The relationship between superficial muscle activity during the cranio-cervical flexion test and clinical features in patients with chronic neck pain.

    Science.gov (United States)

    O'Leary, Shaun; Falla, Deborah; Jull, Gwendolen

    2011-10-01

    Changes in motor behavior are a known feature of chronic mechanical neck pain disorders. This study examined the strength of the association between reported levels of pain and disability from 84 individuals (63 women, 21 men) with chronic mechanical neck pain and levels of electromyographic activity recorded from superficial cervical flexor (sternocleidomastoid; SCM and anterior scalene; AS) muscles during progressive stages of the cranio-cervical flexion muscle test. A significant positive association was observed between superficial muscle activity and pain intensity (P 0.5) or perceived disability (P > 0.21). The strongest relationship between pain intensity and superficial muscle activity occurred at the final increment of the cranio-cervical flexion test (inner-range test position) for both the SCM and AS muscles (R(2) = 0.16). Although a positive and significant relationship between pain intensity and superficial muscle activity was shown, the relationship was only modest (16% explained variance), indicating that multiple factors contribute to the altered motor function observed in individuals with chronic mechanical neck pain.

  19. Establishing the Validity of the Affirmative Training Inventory: Assessing the Relationship between Lesbian, Gay, and Bisexual Affirmative Training and Students' Clinical Competence

    Science.gov (United States)

    Carlson, Thomas Stone; McGeorge, Christi R.; Toomey, Russell B.

    2013-01-01

    This study established the validity and factor structure of the Affirmative Training Inventory (ATI; T. S. Carlson, C. R. McGeorge & M. Rock, unpublished) as a measure of lesbian, gay, and bisexual (LGB) affirmative clinical training. Additionally, this study examined the latent associations among the subscales of the ATI and the Sexual…

  20. Is anti-doping analysis so far from clinical, legal or forensic targets?: The added value of close relationships between related disciplines.

    Science.gov (United States)

    Segura, Jordi

    2009-11-01

    There are many areas of common interest between anti-doping laboratories and those working in the clinical, legal and forensic fields. In addition to methodological similarities, there are aspects of the findings in sport drug testing that overlap with other fields in such a way that sport drug testing and clinical, legal or forensic work may benefit from mutual interaction. Three recent examples are presented from the author's experience. Case report 1 concerns the clinical relevance of hCG findings in sport drug testing as potential indicators of the presence of a (testicular) tumour in athletes. Case report 2 refers to difficulties that accredited laboratories can encounter due to differences between national legal systems and the administrative regulation systems of sport authorities. The example involves a network of blood collection for further autologous transfusion. Case report 3 relates to additional forensic-type investigations needed to interpret a situation where intoxication of a whole delegation was responsible for apparent doping cases. Clinical, legal and forensic fields must recognize the added value that some results and developments coming from anti-doping laboratories may have. At the same time anti-doping analysts should be aware of new issues, methodologies and problems appearing in related fields.

  1. A systematic review of the relationship between patient mix and learning in work-based clinical settings. A BEME systematic review: BEME Guide No. 24

    NARCIS (Netherlands)

    Jong, J. de; Visser, M. de; Dijk, N. van; Vleuten, C.P.M. van der; Waard, M. de

    2013-01-01

    Background: Clinical workplace-based learning has been the means to becoming a medical professional for many years. The importance of an adequate patient mix, as defined by the number of patients and the types of medical problems, for an optimal learning process is based on educational theory and re

  2. General practice and specialist palliative care teams: an exploration of their working relationship from the perspective of clinical staff working in New Zealand.

    Science.gov (United States)

    Keane, Barry; Bellamy, Gary; Gott, Merryn

    2017-01-01

    With the future focus on palliative and end-of-life care provision in the community, the role of the general practice team and their relationship with specialist palliative care providers is key to responding effectively to the projected increase in palliative care need. Studies have highlighted the potential to improve co-ordination and minimise fragmentation of care for people living with palliative care need through a partnership between generalist services and specialist palliative care. However, to date, the exact nature of this partnership approach has not been well defined and debate exists about how to make such partnerships work successfully. The aim of this study was to explore how general practice and specialist palliative care team (SPCT) members view their relationship in terms of partnership working. Five focus group discussions with general practices and SPCT members (n = 35) were conducted in 2012 in two different regions of New Zealand and analysed using a general inductive approach. The findings indicate that participants' understanding of partnership working was informed by their identity as a generalist or specialist, their existing rules of engagement and the approach they took towards sustaining the partnership. Considerable commitment to partnership working was shown by all participating teams. However, their working relationship was based primarily on trust and personal liaison, with limited formal systems in place to enable partnership working. Tensions between the cultures of 'generalism' and 'specialism' also provided challenges for those endeavouring to meet palliative care need collaboratively in the community. Further research is required to better understand the factors associated with successful partnership working between general practices and specialist palliative care in order to develop robust strategies to support a more sustainable model of community palliative care.

  3. Clinical significance of serum carbohydrate antigen 19-9 and its relationship with blood glucose in patients with type 2 diabetes

    Institute of Scientific and Technical Information of China (English)

    武秀玲

    2013-01-01

    Objective To study the relationship between serum carbohydrate antigen 19-9 (CA19-9) and blood glucose level in patients with type 2 diabetes (T2DM) .Methods Totally 784 T2DM patients and 197 healthy controls were enrolled in this study.Age,duration,body mass index (BMI) ,systolic blood pressure (SBP) ,diastolic blood pressure (DBP) ,levels of fasting blood glucose (FBG) ,postprandial blood glucose (PBG) ,hemoglobin A1c (HbA1c) ,total cholesterol (TC) ,triglyceride (TG) ,

  4. Concomitant relationship and clinical signifiance of the arteries and veins of hand%手部动静脉伴行关系及临床意义

    Institute of Scientific and Technical Information of China (English)

    李忠华; 钟世镇; 石瑾; 王兴海; 洪辉文; 刘畅

    2001-01-01

    目的:为手外科提供手部动、静脉伴行关系的规律性。方法:10例新鲜带前臂的手部标本,血管分别灌注过氯乙烯乙酸乙酯或乳胶填充剂,制成动、静脉分色腐蚀铸型标本和解剖剥制标本,观察手部动、静脉伴行关系。结果:手部浅、深血管弓,掌心血管,指掌侧总血管动、静脉呈紧密伴行关系。手掌侧和背侧部浅血管以及手指的掌侧和背侧部血管,动、静脉无伴行关系或伴行不紧密。结论:手部动静脉血管配布规律是:浅层血管呈网络型分布,动静脉无伴行关系,越接近深部,动静脉伴行关系越紧密。指部血管伴行关系都不紧密或没有伴行关系。%Objective: To provide hand surgery with the regularity of concomitant relationship between the arteries and veins of hand.Methods: Concomitant relationship between the arteries and veins of hand were observed in 10 sides decicolor cast specimens and stuffing specimens perfused with hyperchlororinylaceticether or emulsoid.Results: Tight concomitant relationship was observed in the superficial and deep arcus vasclar, palmar metacarpal vessels and common palmar digital vessels.In the palm and the opisthenar, the superficial vessels were not concomitant or not concomitant tightly, so were the vessels of maniphalanx.Conclusion: The distribution regularity between the arteries and veins of hand was showed as follow: Like a network, vessels are not concomitant in the superficial laminae of hand.However, deeper to the partes profunda of the hand, more tight concomitant relationship between the arteries and veins was found.The vessels of the maniphalanx are not concomitant or not tight concomitant.

  5. Clinic attenders with autism or attention-deficit/hyperactivity disorder: cognitive profile at school age and its relationship to preschool indicators of language delay.

    Science.gov (United States)

    Hagberg, Bibbi S; Miniscalco, Carmela; Gillberg, Christopher

    2010-01-01

    Many studies have shown that children with autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) have had early indicators of language delay. The aim of the present study was to examine the cognitive profile of school age children referred to a specialist clinic for ASD, ADHD, or both, and relate this profile specifically to the age at which these children were first flagged up (or not) as suspected from language delay during the preschool years. Forty clinic children with ASD, ADHD, or the combination of the two (without clinical suspicion of learning disability) were assessed cognitively and as regards language development and language function at a mean age of 7.3 years. They were contrasted with a group of 21 children from the community who had been flagged at 2.5 years as suspected of language delay, and who had been followed up neuropsyhiatrically/neuropsychologically and in respect of language at a mean age of 7.9 years. Mean WISC-III full scale IQ was lower than population norms (in spite of the exclusion in both samples of cases with obvious learning disability) and similar across diagnostic groups (ASD and ADHD), and across settings (clinic and community). WISC-III Kaufman factor profiles separated the diagnostic groups as regards Perceptual Organisation. Early concern about language delay was a strong predictor of lower IQ and of distinguishing between "pure" cases of ASD and ADHD. School age clinic children who present with ASD and ADHD have a similar cognitive and early language development profile as do those children from the community, followed prospectively, who present with a suspicion of early preschool language delay and are shown at school age to suffer from ASD or ADHD. Concern about early language delay in the preschool age should prompt assessments (psychiatric and cognitively) for ASD and ADHD in a multidisciplinary setting much more often than is currently the case. In many cases early language delay, even in

  6. 上海市护理人员情绪智力与工作绩效相关性研究%Study on the Relationship between Clinical Nursing Staff' Emotional Intelligence and Their Job Performances in Shanghai

    Institute of Scientific and Technical Information of China (English)

    周海燕; 江有琴

    2012-01-01

    目的 了解上海市护理人员情绪智力水平和工作绩效现状,探讨两者之间的关系.方法 采用问卷调查法,随机抽取上海市两家三级综合性医院和一家二级综合性医院共260名临床一线护理人员进行调查.结果 护理人员整体情绪智力水平呈中等偏上程度(3.63±0.37),护理人员工作绩效的自评得分略高于护士长的他评,但其差异没有统计学意义(P>0.05),情绪智力与工作绩效各维度呈正相关(P<0.05).结论 护理人员情绪智力水平的提高可促进护理工作绩效.%Objectives To investigate the nurses'emotional intelligence and job performances, and analyze the relationships between them. Methods Total 260 clinical nurses in two level - three hospitals and one level -two hospital in shanghai were surveyed with questionnaires about the relationships between the nurses'emotional intelligence and job performances. Results It were showed that nurses'emotional intelligence was in the middle lev-el(3.63 ±0. 37) , and there was no significant difference between the scores of self - rating and other - rating of performance(P >0.05). There was a positive relationship between the nurses'emotional intelligence and job performance(P <0. 05). Conclusion The improvement of emotional intelligence can promote job performance of the clinical nurs

  7. Lack of relationship between EGFR-1 immunohistochemical expression and prognosis in a multicentre clinical trial of 93 patients with advanced primary ovarian epithelial cancer (GINECO group).

    Science.gov (United States)

    Elie, C; Geay, J F; Morcos, M; Le Tourneau, A; Girre, V; Broët, P; Marmey, B; Chauvenet, L; Audouin, J; Pujade-Lauraine, E; Camilleri-Broët, S

    2004-08-02

    Epidermal growth factor receptor 1 (EGFR-1) overexpression is usually described as linked with a worse prognosis in a variety of tumours of epithelial origin. However, its role in ovarian cancer is still controversial. The aim of the present study was to analyse the prognostic impact of EGFR-1 in a retrospective series of 93 stage III-IV primary ovarian epithelial tumours. All patients, enrolled in a multicentre GINECO prospective clinical trial, were treated with the same platinum-based combination chemotherapy, and were followed up with a median of 69 months. Epidermal growth factor receptor 1 plasma membrane expression, assessed by immunohistochemistry on paraffin-embedded tissues, was correlated with clinical parameters as well as immunohistochemical expression results of HER-2 (c-erbB-2), BAX, BCL-2, p53 and anti-Ki-67, previously studied in the same series of patients. Positive immunostaining for EGFR-1 was seen in 31 of the 93 analysed cases (33%). No correlation was found between EGFR-1 expression and clinical parameters. No correlation was found between EGFR-1 expression and other biological markers, except for HER-2, which was limit for significance. Indeed, among the EGFR-1-negative cases, 10.3% expressed HER-2, whereas the HER-2-expressing tumours accounted for 27.6% of EGFR-1-positive cases (P=0.06). Epidermal growth factor receptor 1 overexpression had no prognostic impact on both overall and progression-free survival through univariate and multivariate analyses. The potential effect of EGFR-1 and HER-2 co-expression on targeted therapy against EGFR-1 and/or HER-2 molecules has to be further analysed.

  8. The Relationship of Proper Skin Cleansing to Pathophysiology, Clinical Benefits, and the Concomitant Use of Prescription Topical Therapies in Patients with Acne Vulgaris.

    Science.gov (United States)

    Levin, Jacquelyn

    2016-04-01

    Patients often perceive the cause of their acne to be related to a lack of proper cleansing, therefore many patients attempt to treat their acne either alone or with prescription therapy by frequent aggressive cleansing with harsh cleansing agents. Altered epidermal barrier function, inflammation, and Propionibacterium acnes are related to acne vulgaris (AV) pathophysiology; proper cleansing can favorably modulate the development of AV. The available clinical studies support gentle cleansing in AV by showing the ability to contribute to improving AV lesion counts and severity and minimizing the irritation seen with topical AV therapies such as retinoids and BP.

  9. Relationship between clinical nurse′s psychological capital and caring ability%临床护士心理资本与关爱能力的关系分析

    Institute of Scientific and Technical Information of China (English)

    朱亚芹

    2015-01-01

    Objective To investigate the clinical nurse′s psychological capital and caring ability, and analyze their relationship between them. Methods The psychological capital questionnaire ( PCQ) and caring ability rating form ( CAI ) were used to investigate 268 clinical nurses, and the relationship was analyzed between psychological capital and caring ability. Results The total score of PCQ was (81. 44 ± 14. 13) and total score of CAI was (191. 21 ± 20. 48);the psychological capital was positive correlated with caring ability ( r=0.295-0.438,P< 0. 01). Conclusions The psychological capital and caring ability are low in clinical nurses, so nursing managers should focus on nurse′s psychological capital so as to enhance nurse′s caring ability.%目的:调查临床护士心理资本与关爱能力状况,分析两者的关系。方法采用心理资本问卷( PCQ)和关爱能力评价表( CAI)对268名临床护士进行问卷调查,对护士心理资本与关爱能力的关系进行分析。结果护士PCQ总分为(81.44±14.13)分,CAI总分为(191.21±20.48)分,心理资本与关爱能力呈正相关(r值为0.295~0.438,P<0.01)。结论临床护士心理资本水平和关爱能力较低,护理管理者应关注护士心理资本,采取多种措施提升其心理资本,以便提高其护理关爱能力。

  10. Facilitated disclosure versus clinical accommodation of infidelity secrets: an early pivot point in couple therapy. Part 1: couple relationship ethics, pragmatics, and attachment.

    Science.gov (United States)

    Butler, Mark H; Harper, James M; Seedall, Ryan B

    2009-01-01

    A critical and potentially polarizing decision in treating infidelity is whether facilitating partner disclosure or accommodating nondisclosure is most beneficial following private disclosure of infidelity to the therapist. Given couple distress and volatility following disclosure, understandably some therapists judge accommodating an infidelity secret both efficient and compassionate. Employing Western ethics and an attachment/intimacy lens, we consider ethical, pragmatic, and attachment intimacy implications of accommodating infidelity secrets. Issues bearing on the decision to facilitate disclosure or accommodate nondisclosure include (a) relationship ethics and pragmatics; (b) attachment and intimacy consequences; and (c) prospects for healing. We conclude that facilitating voluntary disclosure of infidelity, although difficult and demanding, represents the most ethical action with the best prospects for renewed and vital attachment intimacy.

  11. The relationship between type 2 diabetic patients' early medical care-seeking consistency to the same clinician and health care system and their clinical outcomes.

    Science.gov (United States)

    Liao, Pei-Ju; Lin, Zu-Yu; Huang, Jui-Chu; Hsu, Kuang-Hung

    2015-02-01

    The literature has demonstrated that the continuity of diabetes care can lower medical service utilization and expenses. However, few studies have examined the effects of patients' medical care-seeking behaviors in the early stage after the diagnosis of diabetes on their long-term prognoses. This study aimed to examine the association of medical care-seeking behavior in the first year following diabetes diagnosis on the occurrence of diabetes-related complications among patients in Taiwan. This is a retrospective data collection with follow-up analysis and a nationwide population-based dataset in Taiwan. A total of 89,428 newly diagnosed type 2 diabetes mellitus patients during the period from 2000 to 2006 were followed up until 2010. The patients' medical care-seeking behaviors were classified as follows: high consistency to a physician, high consistency to a medical setting, medium consistency to providers, and low consistency to providers. The occurrence of diabetes-related complications and all-cause mortality were the primary outcomes of this study. Chi-square tests, ANOVAs, and Cox proportional hazard models were applied to examine the relationships between the predictors and medical outcomes. Compared to the patients with high medical care-seeking consistency to a physician, the multivariate-adjusted hazard ratios of diabetes-related complications occurrence among patients in the high consistency to a medical setting, medium consistency, and low consistency categories were 1.112 (95% CI 1.089-1.136, P patient relationship management should be reinforced during the early stage of diabetes care in future medical care systems.

  12. Foot posture, leg length discrepancy and low back pain--their relationship and clinical management using foot orthoses--an overview.

    Science.gov (United States)

    Kendall, Julie C; Bird, Adam R; Azari, Michael F

    2014-06-01

    Mechanical low back pain (LBP) is a very common, expensive, and significant health issue in the western world. Functional musculoskeletal conditions are widely thought to cause mechanical low back pain. The role of foot posture and leg length discrepancy in contributing to abnormal biomechanics of the lumbopelvic region and low back pain is not sufficiently investigated. This critical review examines the evidence for the association between foot function, particularly pronation, and mechanical LBP. It also explores the evidence for a role for foot orthoses in the treatment of this condition. There is a body of evidence to support the notion that foot posture, particularly hyperpronation, is associated with mechanical low back pain. Mechanisms that have been put forward to account for this finding are based on either mechanical postural changes or alterations in muscular activity in the lumbar and pelvic muscles. More research is needed to explore and quantify the effects of foot orthoses on chronic low back pain, especially their effects on lumbopelvic muscle function and posture. The clinical implications of this work are significant since foot orthoses represent a simple and potentially effective therapeutic measure for a clinical condition of high personal and social burden.

  13. The significance of Gd-DTPA enhanced MRI for lumbar disc herniation; The relationship between nerve root enhancement and clinical manifestations

    Energy Technology Data Exchange (ETDEWEB)

    Taneichi, Hiroshi; Abumi, Kuniyoshi; Hirachi, Kazuhiko; Kaneda, Kiyoshi (Hokkaido Univ., Sapporo (Japan). School of Medicine)

    1993-04-01

    The purpose of this study was twofold: to determine the ability of Gd-DTPA enhanced MRI to enhance the nerve root and to determine its clinical value in lumbar disc herniation. One hundred and fifteen patients underwent enhanced MRI before and after surgery. Disturbed nerve root was demonstrated on enhanced MRI before surgery in 39.1% (45/115). Nerve root enhancement was occasionally associated with severe leg pain, but not associated with the degree of paralysis. Nerve root enhancement early after surgery was positive in 27 of 46 patients (58.7%), revealing no clinical usefulness of enhanced MRI. Non-damaged nerve root was enhanced in 7 patients (5.9%). This may reflect enhancement of root vein. Nerve root enhancement has the potential for visualizing endoneurial edema resulting from compression and inflammation of the nerve root. Enhanced MRI demonstrated lesions within the nerve root, allowing identification of damaged nerve root and diagnosis of lumbar disc herniation. (N.K.).

  14. Relationship between striatal [{sup 123}I]{beta}-CIT binding and four major clinical signs in Parkinson's disease

    Energy Technology Data Exchange (ETDEWEB)

    Shinotoh, Hitoshi; Uchida, Yoshitaka; Ito, Hisao; Hattori, Takamichi [Chiba Univ. (Japan). School of Medicine

    2000-06-01

    We investigated the correlation between clinical severity and striatal [{sup 123}I]{beta}-CIT binding in 12 patients with Parkinson's Disease (PD: 6 men and 6 women, age: 65{+-}7 years, Hoehn-Yahr stage: 1 to 3). The clinical severity of PD patients was measured with the Unified Parkinson's Disease Rating Scale (UPDRS) after withdrawal of antiparkinsonian medication at least 12 hours before assessment. [{sup 123}I]{beta}-CIT binding in the caudate and putamen was measured at 3 hours [V''{sub 3} (day 1)], and at 24 hours [V''{sub 3} (day 2)] after tracer injection with small square ROIs. The specific striatal uptake index (day 2) was calculated with large square ROIs that encompassed the whole striatum. The best correlation (r=-0.82, p<0.0012) was between putamenal V''{sub 3} (day 2) and the motor UPDRS scores. When the motor UPDRS scores were divided into four subscales, bradykinesia was the only sign that correlated significantly with putamenal V''{sub 3} (day 2) (r=-0.81, p<0.002). [{sup 123}I]{beta}-CIT SPECT is a useful marker of disease severity in PD with potential utility in the serial monitoring of disease progression. (author)

  15. Relationship of the area measurement of the large endolymphatic duct and sac syndrome as well as the clinical symptoms with CT and MR imaging results

    Energy Technology Data Exchange (ETDEWEB)

    Park, Ji Sang; Hong, Hyun Sook; Lee, Jong Sea; Kim, Dae Ho; Lee, Hae Kyung; Yi, Beom Ha; Cha, Jang Gyu; Park, Seong Jin; Kim, Shi Chan [Soonchunhyang University Bucheon Hospital, Bucheon (Korea, Republic of)

    2008-08-15

    To evaluate the CT and MRI findings of the large endolymphatic duct or sac syndrome (LEDS) and its associated anomalies, with clinical features. We retrospectively reviewed the MR and CT images of 52 ears obtained from 26 patients with LEDS. We reviewed the clinical findings, audiology testing, and treatment results. The degree of hearing loss was classified from normal to profound, based on pure tone audiometry. The largest areas were measured at each endolymphatic duct and analyzed to determine whether a correlation exists with the degree of hearing loss. We also analyzed the differences in measurements between CT and MRI findings. All 26 patients had some degree of sensorineural hearing loss, which resulted in 18 ears to undergo a cochlear implantation. One patient was diagnosed with Cornelia de Lange syndrome. Five patients had a sudden hearing loss onset. Ten ears had incomplete cochlear partitions, whereas 28 ears had enlarged vestibules. All patients had severe to profound hearing loss. We found no statistical correlation between the size of the largest area of the endolymphatic duct and the degree of hearing loss. The mean area of the endolymphatic ducts, as per an MRI examination, revealed slightly greater areas than the CT findings, although the differences were not significant. Enlarged vestibules and incomplete partitions of the cochlea were common anomalies associated with LEDS. We found no statistical correlation between the largest area of the endolymphatic duct or sac with the degree of hearing loss.

  16. Clinical and Pathological Analysis of the Relationship between Children Nephritis%儿童紫癜性肾炎临床和病理关系分析

    Institute of Scientific and Technical Information of China (English)

    李蕾; 张俊毅; 马飞; 鲁红

    2016-01-01

    目的:探讨儿童紫癜性肾炎临床与病理的相关性。方法随机选取2013年3月―2015年7月赤峰学院附属医院儿科收治的100例儿童紫癜性肾炎患儿作为研究的对象,对患儿进行不同临床的分型和病理分析。结果临床分型中100例患儿中临床分型以血尿和蛋白尿型患儿最为常见,占40.0%,其次为肾病综合征型,占29.0%。病理分型中以II级为主,占49.0%,其次为III级,占29.0%。尿检正常型患儿以及孤立性血尿或者蛋白型患儿中肾脏病理的损伤程度较轻,血尿和尿蛋白型中II级较多,占62.5%(25/40﹚,III级占17.5%(7/40﹚。肾病综合征主要以III级为主,占51.7%(15/29﹚;急进性肾炎型主要以VI级为主。发现临床分型与病理分级之间具有很大的相关性(r=0.392,P<0.05﹚。结论儿童紫癜性肾炎临床严重程度与病理损伤的程度保持高度的一致性。%Objective To investigate the purpura nephritis in children with pathologic correlation. Methods Randomly se-lected from March 2013 to July 2015 of 100 children admitted in Chifeng college hospital pediatric children with purpura nephritis as a research object, for children with different clinical classification and pathological analysis. Results Clinical classification in 100 children with clinical classification with hematuria and proteinuria in children is the most common type, accounting for 40.0%, followed by nephrotic syndrome type, accounting for 29.0%. Pathological classification is given priority to with class II, account for 49.0%, followed by level III, accounting for 29.0%. Urine normal type and isolated hematuria or protein in children with type of renal pathology in children with damage to a lesser degree, the class II type is more blood in the urine and urine protein, 62.5% (25/40), level III accounted for 17.5% (7/40). Nephrotic syndrome are mainly composed of level III, accounting for 51.7%(15/29);The accelerated nephritis mainly grade VI. Found

  17. Relationship between career adaptability and clinical communication behavior of undergraduate nursing students%本科实习护生生涯适应力与临床沟通行为的关系

    Institute of Scientific and Technical Information of China (English)

    胡清媛; 孔祥静; 李亚兰; 李健

    2015-01-01

    Objective:To probe into the relationship between career adaptability and clinical communication be-havior of undergraduate nursing students,so as to provide references for improving the clinical communication ability of nursing students.Methods:A total of 552 undergraduate nursing students were assessed by using Chi-nese version of career adaptability and clinical communication skills assessment scale,and to analyze the rela-tionship between the both.Results:The score of career adaptability of undergraduate nursing interns was 3.30± 0.37,the score of clinical communication behavior was 2.63±0.35;the career adaptability was positively corre-lated with clinical communication behaviors;3 dimensions of career concern,career control,and career confidence in career adaptability can predict 28.7%clinical communication behavior.Conclusion:The career adaptability of undergraduate nursing interns were at middle partial level,the overall clinical communication ability was better but needed to further improved.The career adaptability can effectively predict the clinical communication be-havior of undergraduate nursing interns.Nursing managers and educators should further cultivate the career a-daptability of undergraduate nursing interns in order to improve the clinical communication ability.%[目的]探讨本科实习护生生涯适应力与临床沟通行为的关系,为提高本科实习护生的临床沟通能力提供参考。[方法]对552名本科实习护生运用中文版生涯适应力量表和临床沟通能力测评量表进行测试,分析二者的关系。[结果]本科实习护生生涯适应力得分3.30分±0.37分,临床沟通行为得分2.63分±0.35分;生涯适应力与临床沟通行为呈正相关;生涯适应力中生涯关注、生涯控制、生涯自信3个维度能预测临床沟通行为的28.7%。[结论]本科实习护生生涯适应力处于中等偏上水平,临床沟通能力总体较好但需要进一步改善,生涯适应力

  18. Relationship between late preterm birth and expression of attention-deficit hyperactivity disorder in school-aged children: clinical, neuropsychological, and neurobiochemical outcomes

    Directory of Open Access Journals (Sweden)

    Ben Amor L

    2012-08-01

    Full Text Available L Ben Amor,1,2 S Chantal,3 A Bairam41Department of Psychiatry, Hotel Dieu de Levis, 2Department of Psychiatry, Laval University, 3Enfant Jesus Hospital, 4Department of Paediatrics, Laval University, Quebec, CanadaAbstract: Attention-deficit hyperactivity disorder (ADHD is a common neurodevelopmental disorder in school-aged children, and prematurity is a recognized risk factor. Late-preterm birth, which represents 75% of premature births, is associated with ADHD symptoms, impaired cognitive performance, and behavior problems. However, little is known of the characteristics of ADHD associated with late prematurity. The purpose of this study was to compare the clinical, neuropsychological, and neurobiochemical characteristics associated with late-preterm ADHD with those of at-term ADHD.Methods: Eighty-six children with ADHD, aged 5–13 years, were recruited. They included 20 late-preterm children with ADHD and 66 at-term children with ADHD. The Diagnostic Interview Schedule for Children-IV and the Continuous Performance Test (CPT were used to evaluate their clinical and neuropsychological characteristics. Proton magnetic resonance spectroscopy was used to measure the ratio of metabolites (glutamate, choline, and N-acetyl-aspartate to creatine in both the prefrontal and striatal regions as well as the left cerebellum.Results: The groups did not differ in regards to clinical outcomes. However, the ADHD late-preterm group had worse omissions and commissions T-scores on CPT (P ≤ 0.05 than the ADHD at-term group. The ADHD late-preterm group also had lower ratios of glutamate in the left prefrontal cortex than the ADHD at-term group (P ≤ 0.05.Conclusion: Among children with ADHD, those born at late preterm have lower attention scores as evaluated by CPT and are associated with lower relative concentrations of glutamate in the prefrontal region than those born at term. Etiological factors could play a role in the expression of ADHD

  19. Relationship between depressive symptoms, alcohol use, and antiretroviral therapy adherence among HIV-infected, clinic-attending patients in South Africa.

    Science.gov (United States)

    Magidson, Jessica F; Saal, Wylene; Nel, Adriaan; Remmert, Jocelyn E; Kagee, Ashraf

    2016-02-15

    Despite the prevalence of depression and alcohol use among HIV-infected individuals, few studies have examined their association together in relation to nonadherence to antiretroviral therapy in sub-Saharan Africa. This study examined depressive symptoms, alcohol use, and other psychosocial factors (stigma, demographic characteristics) in relation to nonadherence to antiretroviral therapy among clinic-attending, HIV-infected individuals in South Africa (n = 101). Nonadherence was assessed using event-level measurement (missed doses over the past weekend). Multivariable logistic regression analyses revealed that only alcohol use, over and above depressive symptoms and education level, was associated with antiretroviral therapy nonadherence(AOR = 1.15; 95%CI = 1.02-1.29; p < .05). Findings point to the independent association of alcohol use and nonadherence to antiretroviral therapy above and beyond depressive symptoms.

  20. 白癜风光疗疗效与临床的关系%Relationship between the efficacy of phototherapy and clinical factors in patients with vitiligo

    Institute of Scientific and Technical Information of China (English)

    邱实; 许爱娥

    2013-01-01

    白癜风是一种色素脱失性疾病,以皮肤或黏膜色素减退为特征,多为后天发病,可见于任何年龄,以青壮年多见,部分患者有明显的季节性,一般春末夏初病情加重,冬季缓解.任何部位均可发病,但好发于暴露部位.该病治疗困难,影响美观,给患者带来精神心理压力.目前运用较广泛的有308 nm准分子激光、窄谱中波紫外线和氦氖激光等,临床应用发现,光疗的疗效与白癜风分型、部位、病程、治疗次数、皮肤类型和红斑反应等相关.%Vitiligo is a pigmentary disorder characterized by cutaneous or mucous hypopigmentation.It is usually acquired,and may occur at any age,but is more common in young adults.In some patients with vitiligo,the condition gets worse at late spring and early summer,but better in winter.It may affect any body sites with a predilection for exposed sites.Vitiligo can bring psychical and mental stress to patients by affecting their appearance,however,it still remains difficult to treat.At present,commonly used phototherapy for vitiligo includes 308-nm excimer laser,narrow band-ultraviolet B,helium neon laser,etc.Clinical practice has suggested that the efficacy of phototherapy is associated with the type,site,clinical course of vitiligo,as well as treatment sessions,skin types and erythema reaction of patients.

  1. Clinical significance of miR-140-5p and miR-193b expression in patients with breast cancer and relationship to IGFBP5

    Directory of Open Access Journals (Sweden)

    Gökçe Güllü

    2015-03-01

    Full Text Available The functional role of IGFBP5 in breast cancer is complicated. Experimental and bioinformatics studies have shown that IGFBP5 is targeted by miR-140-5p and miR-193b, although this has not yet been proven in clinical samples. The aim of this study was to evaluate the expression of miR-140-5p and miR-193b in breast cancer and adjacent normal tissue and assess its correlation with IGFBP5 and the clinicopathological characteristics of the tumors. IGFBP5 protein expression was analyzed immunohistochemically and IGFBP5, miR-140 and miR-193b mRNA expression levels were analyzed with real-time RT-PCR. Tumor tissue had higher miR-140-5p expression than adjacent normal tissue (p = 0.015. Samples with no immunohistochemical staining for IGFBP5 showed increased miR-140-5p expression (p = 0.009. miR-140-5p expression was elevated in invasive ductal carcinomas (p = 0.002, whereas basal-like tumors had decreased expression of miR-140-5p compared to other tumors (p = 0.008. Lymph node-positive samples showed an approximately 13-fold increase in miR-140-5p expression compared to lymph node-negative tissue (p = 0.049. These findings suggest that miR-140-5p, but not miR-193b, could be an important determinant of IGFBP5 expression and clinical phenotype in breast cancer patients. Further studies are needed to clarify the expressional regulation of IGFBP5 by miR-140-5p.

  2. Relationship between Clinical Parameters and Brain Structure in Sporadic Amyotrophic Lateral Sclerosis Patients According to Onset Type: A Voxel-Based Morphometric Study

    Science.gov (United States)

    de Leon, Mony; Wang, Xiuyuan; Kim, Hyun Young; Lee, Young-Jun; Kim, Yeon-Ha; Kim, Seung Hyun

    2017-01-01

    Background and purpose Amyotrophic lateral sclerosis (ALS) is a rapidly progressing, phenotypically heterogeneous neurodegenerative disease affecting mainly the motor neuron system. The present voxel-based morphometry (VBM) study investigated whether patterns of brain atrophy differ among sporadic ALS subtypes. Material and methods Sporadic ALS patients (n = 62) with normal cognition and age-matched healthy controls (n = 57) were included in the study. ALS patients were divided into limb- and bulbar-onset groups according to clinical manifestations at symptom onset (n = 48 and 14, respectively). Clinical measures were ALS Functional Rating Scale-Revised (ALSFRS-R) score, disease duration, and forced vital capacity (FVC). Patterns of brain atrophy between ALS subgroups were compared by VBM. Results In limb-onset ALS patients, atrophy was largely confined to the motor cortex and adjacent pre- and postcentral regions. However, in the bulbar-onset group, affected regions were more widespread and included these same areas but also extended to the bilateral frontotemporal and left superior temporal and supramarginal gyri, and multiple regression analysis revealed that their ALSFRS-R scores were associated with extensive loss of gray matter while FVC was related to atrophy in subcortical regions of the left superior temporal gyrus. In limb-onset ALS patients, disease duration was related to the degree of atrophy in the motor and adjacent areas. Conclusion Sporadic ALS subtypes show different patterns of brain atrophy. Neural networks related to limb and bulbar motor functions in each ALS subtype may underlie their distinct patterns of cerebral atrophy. That is, more extensive cortical and subcortical atrophy is correlated with greater ALSFRS-R severity and shorter disease duration in the bulbar-onset subtype and may explain the poor prognosis of these patients. PMID:28095425

  3. Relationship of Epstein-Barr virus and interleukin 10 promoter polymorphisms with the risk and clinical outcome of childhood Burkitt lymphoma.

    Directory of Open Access Journals (Sweden)

    Carolina Minnicelli

    Full Text Available Epstein-Barr virus (EBV is an important environmental factor associated to the development of Burkitt lymphoma (BL in endemic and intermediate risk regions. However, little is known about the contribution of genetic constitution to the development and clinical response of the disease. The aim of this work was to investigate the role of EBV and Interleukin 10 (IL10 single nucleotide polymorphisms (-1082A/G, -819C/T, -592C/A and microsatellites (IL10.R and IL10.G in susceptibility and clinical outcome in pediatric BL patients, in a region with intermediate EBV association frequency. The frequencies of IL10 promoter Single nucleotide polymorphisms -1082A/G, -819C/T, -592C/A, and IL10.R and IL10.G microsatellites were compared in 62 pediatric patients and 216 healthy donors. IL10 -1082GG and GCC/GCC genotypes were more frequent in patients than in controls, and associated to a higher risk of BL development (GG genotype OR 2.62, 95% CI, 1.25-5.51; P = 0.008; Pc = 0.024. EBV was detected in tumor samples by EBER-ISH in 54.1% of cases. EBV+ patients exhibited a better event free survival (EFS (P = 0.019 than EBV- patients. Carriers of IL10 R3-GCC had worse EFS (P = 0.028. Our results suggest a risk effect and an independent prognostic value of IL10 polymorphisms and EBV in childhood BL patients.

  4. 实习护生对临床学习环境的评价与其职业态度关系探讨%Relationship between evaluation of clinical learning environment and professional attitude among undergraduate nursing students

    Institute of Scientific and Technical Information of China (English)

    徐江华; 王宁

    2012-01-01

    目的 探讨本科实习护生对临床学习环境(CLE)的评价与其职业态度的关系.方法 选取2所医学院校本科实习护生219名,采用护理专业自我概念量表及护理临床学习环境评价量表进行调查.结果 护生CLE总评分为137.84±20.81,职业态度总评分为85.89±10.32;护生对CLE评价与其职业态度呈正相关(P<0.01);学生参与性、人际关系、工作氛围和团队精神对护生职业态度有显著影响(均P<0.01).结论 CLE可影响护生职业态度,护生对CLE评价与其职业态度显著相关,学生参与性、人际关系、工作氛围和团队精神是影响护生职业态度的主要因素.%Objective To investigate the relationship between undergraduate nursing students evaluation of clinical learning environment (CLE) and their professional attitude. Methods A total of 219 undergraduate nursing students were selected from two medical schools and surveyed by using the Professional Self-concept of Nurses Instrument and the Clinical Learning Environment Inventory. Results The total CLE score was 137. 84±20. 81 and students' professional attitude scored 85. 89±10. 32. Students' evaluation of CLE was positively related to their professional attitude (P<0. 01) ; students' professional attitude was significantly related to student involvement, interpersonal relationship, working atmosphere, and team cooperation(P<0. 01 for all). Conclusion Clinical learning environment has impact on professional attitude of undergraduate nursing students. Student involvement, interpersonal relationship, working atmosphere, and team cooperation influence students' professional attitude.

  5. One-Year Follow-up of Children and Adolescents with Major Depressive Disorder: Relationship between Clinical Variables and Abcb1 Gene Polymorphisms.

    Science.gov (United States)

    Blázquez, A; Gassó, P; Mas, S; Plana, M T; Lafuente, A; Lázaro, L

    2016-11-01

    Introduction: Differences in response to fluoxetine (FLX) may be influenced by certain genes that are involved in FLX transportation (ABCB1). We examined remission and recovery from the index episode in a cohort of patients treated with FLX, and also investigated associations between genetic variants in ABCB1 and remission, recovery, and suicide risk. Methods: This was a naturalistic 1-year follow-up study of 46 adolescents diagnosed with major depressive disorder (MDD). At 12 months they underwent a diagnostic interview with the K-SADS-PL. Results: It was found that remission was around 69.5% and recovery 56.5%. Remission and recovery were associated with lower scores on the CDI at baseline, with fewer readmissions and suicide attempts, and with lower scores on the CGI and higher scores on the GAF scale. No relationship was found between ABCB1 and remission or recovery. However, a significant association was observed between the G2677T ABCB1 polymorphism and suicide attempts. Conclusion: Other factors such as stressful events, family support, and other genetic factors are likely to be involved in MDD outcome.

  6. Relationship between innate immunity, soluble markers and metabolic-clinical parameters in HIV+ patients ART treated with HIV-RNA<50 cp/mL

    Directory of Open Access Journals (Sweden)

    Chiara Dentone

    2014-11-01

    Full Text Available Introduction: The persistence of immune activation and inflammation in HIV patients with HIV-RNA (VL undetectable causes many co-morbidities [1–3]. The aim of this study is to correlate monocytes (m and NK cell activation levels, soluble markers and oxidative stress with clinical, biochemical and metabolic data in HIV-1 infected patients with VL≤50 copies (cp/mL on antiretroviral therapy. Materials and Methods: Multicentre, cross-sectional study in patients with VL≤50 cp/mL and on antiretroviral therapy by at least six months. We studied: activation/homing markers (CD38, HLA-DR, CCR-2, PDL-1 on inflammatory, intermediate, proinflammatory m; activatory receptors NKp30, NKp46 and HLA-DR on NK cells; soluble inflammatory (sCD14, adiponectina, MCP-1 and stress oxidative markers (dRoms, antiRoms. Univariate analyses are performed with non-parametric and Pearson tests. The significant correlations were adjusted for possible known confounding factors (smoking, Cytomegalovirus IgG serology, Raltegravir, Protease Inhibitor [PI] therapy and HCV-RNA with multivariate analysis. Results: In the 68 patients the positive correlation between age and antiRoms was significant also after adjustment for PI use (p=0.05. The% CD8+T was associated with% proinflammatory m (p=0.043 and with their expression of CCR2 mean fluorescence intensity (MFI (p=0.012. The% NKp46+ was positively correlated with CD4+T count (p=0.001. The fibrinogen was positively associated with dRoms (p=0.052 and the positive correlation between triglycerides and antiRoms has been confirmed (p<0.001; the impact of antiRoms on HDL/triglycerides ratio (p=0.006 was observed after adjustment for PI use. The BMI was associated with smoking (p=0.011. Only the maraviroc-treated patients showed minimal arterial pressure, fibrinogen and antiRoms lower (p=0.001, 0.004 e 0.006 and sCD14 values higher (p=0.029. Conclusions: Patients with long history of HIV infection and stable immunological and

  7. Relationship between Potential Sperm Factors Involved in Oocyte Activation and Sperm DNA Fragmentation with Intra-Cytoplasmic Sperm Injection Clinical Outcomes

    Science.gov (United States)

    Tavalaee, Marziyeh; Kiani-Esfahani, Abbas; Nasr-Esfahani, Mohammad Hossein

    2017-01-01

    Objective The present study aimed to simultaneously evaluate the association between expression of three potential factors [post-acrosomal sheath WW domain-binding protein (PAWP), phospholipase Cζ (PLCζ), and truncated form of the kit receptor (TR-KIT)] as candidates of oocyte activation with fertilization rate and early embryonic development. Materials and Methods In this experimental study, semen samples were collected from 35 intra-cytoplasmic sperm injection (ICSI) candidates and analyzed according to World Health Organization criteria (2010). Each sample was divided into two parts. The first part was processed for insemination by density-gradient centrifugation (DGC) and the second part was prepared for assessment of sperm morphology (Papanicolaou staining), DNA fragmentation [transferase dUTP nick end labeling (TUNEL)], and three Sperm-borne oocyte-activating factor (s) (SOAFs)-PLCζ, PAWP, and TR-KIT. Results Significant positive correlations existed between the percentages of PLCζ, PAWP, and TR-KIT with fertilization rate. In addition, significant negative correlations existed between the percentage of DNA fragmentation with the percentages of PLCζ and PAWP. We did not find a relationship between percentages of PLCζ, PAWP, and TR-KIT with embryo quality and pregnancy rate (P>0.05). There was a significant negative correlation between percentage of DNA fragmentation with fertilization and embryo quality. Conclusion Oocyte activation was associated with the studied sperm factors (PAWP, PLCζ, and TR-KIT). These factors might hold the potential to be considered as diagnostic factors in the assessment of semen samples to evaluate their potential to induce oocyte activation. In addition, we observed a significant association between DNA fragmentation with fertilization, as well as embryo quality and expression of PAWP and PLCζ, which indicated that men with high degrees of DNA fragmentation might require artificial oocyte activation. Whether such action

  8. Relationship between Potential Sperm Factors Involved in Oocyte Activation and Sperm DNA Fragmentation with Intra-Cytoplasmic Sperm Injection Clinical Outcomes

    Directory of Open Access Journals (Sweden)

    Marziyeh Tavalaee

    2016-10-01

    Full Text Available Objective: The present study aimed to simultaneously evaluate the association between expression of three potential factors [post-acrosomal sheath WW domain-binding protein (PAWP, phospholipase Cζ (PLCζ, and truncated form of the kit receptor (TR-KIT] as candidates of oocyte activation with fertilization rate and early embryonic development. Materials and Methods: In this experimental study, semen samples were collected from 35 intra-cytoplasmic sperm injection (ICSI candidates and analyzed according to World Health Organization criteria (2010. Each sample was divided into two parts. The first part was processed for insemination by density-gradient centrifugation (DGC and the second part was prepared for assessment of sperm morphology (Papanicolaou staining, DNA fragmentation [transferase dUTP nick end labeling (TUNEL], and three Sperm-borne oocyte-activating factor (s (SOAFs-PLCζ, PAWP, and TR-KIT. Results: Significant positive correlations existed between the percentages of PLCζ, PAWP, and TR-KIT with fertilization rate. In addition, significant negative correlations existed between the percentage of DNA fragmentation with the percentages of PLCζ and PAWP. We did not find a relationship between percentages of PLCζ, PAWP, and TR-KIT with embryo quality and pregnancy rate (P>0.05. There was a significant negative correlation between percentage of DNA fragmentation with fertilization and embryo quality. Conclusion: Oocyte activation was associated with the studied sperm factors (PAWP, PLCζ, and TR-KIT. These factors might hold the potential to be considered as diagnostic factors in the assessment of semen samples to evaluate their potential to induce oocyte activation. In addition, we observed a significant association between DNA fragmentation with fertilization, as well as embryo quality and expression of PAWP and PLCζ, which indicated that men with high degrees of DNA fragmentation might require artificial oocyte activation. Whether

  9. A clinical investigation of the relationship between different sedation depths and the restlessness after using midazolam as an adjuvant during regional anesthesia

    Institute of Scientific and Technical Information of China (English)

    Cunming Liu; Guolou Zhang; Mei Gao; Zhongyun Wang; Qianqing Wang; Chuanbao Han; Xiufeng Hao

    2006-01-01

    Objective: To investigate the relationship between different sedation depth and the restlessness after using midazolam as an adjuvant during regional anesthesia. Methods: One hundred and fifty patients undergoing regional anesthesia were randomly divided into three groups. In group A, the patients were sedated at the level of OAA/S Ⅳ with midazolam during regional anesthesia. In group B and C, the sedation depths were kept at the levels of Ⅲ and Ⅱ respectively. The changes of BP, HR and SpO2 were recorded before and after midazolam.The rate of restlessness was also evaluated. Results: Blood pressures decreased in certain degree at 5 and 10 min after midazolam compared with those before in all three groups. BP decreased over 20% of the baseline in 4 cases in group A, in 5 cases in group B, and in 5 cases in group C. There was no significant difference in BP dropping among three groups. Compared with group B and C SpO2 dropped significantly at 3 and 5 min after midazolam in group C, in which SpO2 was less than 93% in 8 cases. The restlessness rate in group C was 22%, which was significantly higher than those in group A (2% ,P<0.01) and group B(4% ,P<0.05). Conclusion: The sedation depth is related to the rate of restlessness when midazolam is used as an adjuvant during regional anesthesia. It is suggested that the appropriate sedation depth for the patients under regional anesthesia is OAA/S Ⅲ.

  10. TH与乳腺疼痛的相关临床研究%Clinical study on relationship between thyroid gland related hormone and hyperplasia of mammary gland

    Institute of Scientific and Technical Information of China (English)

    徐虓; 刘志英; 孙祝生; 刘会岭

    2015-01-01

    Objective: To study the correlation between thyroid hormone levels and breast pain rating, mammary gland thickness, and gland hyperplasia degree. Methods: From January 2010 to June 2013, 130 patients with breast pain as the chief complaint to the hospital were randomly selected. Correlation between breast pain rating, mammary gland thickness, gland hyperplasia degree and thyroid stimulating hormone (TSH), triiodothyronine (T3), tetraiodothyronine (T4), thyroid peroxidase antibodies (TPO), thyroglobulin antibody (TG), TSH receptor antibody (Anti-TSHR), mammary gland disorder, and thyroid disease were analyzed. Results: Degree of breast hyperplasia is unrelated with serum T3, T4, TPO, TG, Anti-TSHR level (P>0.05), and it is related with serum TSH levels (P=0.002, P0.05). There is no significant relationship between mammary gland hyperplasia degree and the gland structural disorder (P>0.05), while the correlation of mammary gland hyperplasia degree with presence of thyroid disease is significant. Patients with thyroid disease are apt to have severer mammary gland hyperplasia (P0.05),与血清TSH水平相关(P=0.002,P0.05).乳腺增生程度与乳腺腺体结构紊乱之间无明显关系(P>0.05),与是否有甲状腺疾患有关,有甲状腺疾患者乳腺增生程度较重(P<0.05).结论:血清TSH升高可引起乳腺增生,乳腺疼痛程度与甲状腺相关激素水平无关.中重度乳腺增生患者往往合并甲状腺疾患.

  11. Categorization of fragrance contact allergens for prioritization of preventive measures: clinical and experimental data and consideration of structure-activity relationships.

    Science.gov (United States)

    Uter, Wolfgang; Johansen, Jeanne D; Börje, Anna; Karlberg, Ann-Therese; Lidén, Carola; Rastogi, Suresh; Roberts, David; White, Ian R

    2013-10-01

    Contact allergy to fragrances is still relatively common, affecting ∼ 16% of patients patch tested for suspected allergic contact dermatitis, considering all current screening allergens. The objective of the review is to systematically retrieve, evaluate and classify evidence on contact allergy to fragrances, in order to arrive at recommendations for targeting of primary and secondary prevention. Besides published evidence on contact allergy in humans, animal data (local lymph node assay), annual use volumes and structure-activity relationships (SARs) were considered for an algorithmic categorization of substances as contact allergens. A total of 54 individual chemicals and 28 natural extracts (essential oils) can be categorized as established contact allergens in humans, including all 26 substances previously identified as contact allergens (SCCNFP/0017/98). Twelve of the 54 individual chemicals are considered to be of special concern, owing to the high absolute number of reported cases of contact allergy (>100). Additionally, 18 single substances and one natural mixture are categorized as established contact allergens in animals. SARs, combined with limited human evidence, contributed to the categorization of a further 26 substances as likely contact allergens. In conclusion, the presence of 127 single fragrance substances and natural mixtures should, owing to their skin sensitizing properties, be disclosed, for example on the label. As an additional preventive measure, the maximum use concentration of 11 substances of special concern should be limited to 100 ppm. The substance hydroxyisohexyl 3-cyclohexene carboxaldehyde and the two ingredients chloroatranol and atranol in the natural extracts Evernia prunastri and Evernia furfuracea should not be present in cosmetic products.

  12. Frequent Promoter Methylation of CDH1, DAPK, RARB, and HIC1 Genes in Carcinoma of Cervix Uteri: Its Relationship to Clinical Outcome

    Directory of Open Access Journals (Sweden)

    Schneider Achim

    2003-05-01

    Full Text Available Abstract Background Cervical cancer (CC, a leading cause of cancer-related deaths in women worldwide, has been causally linked to genital human papillomavirus (HPV infection. Although a host of genetic alterations have been identified, molecular basis of CC development is still poorly understood. Results We examined the role of promoter hypermethylation, an epigenetic alteration that is associated with the silencing tumor suppressor genes in human cancer, by studying 16 gene promoters in 90 CC cases. We found a high frequency of promoter methylation in CDH1, DAPK, RARB, and HIC1 genes. Correlation of promoter methylation with clinical characteristics and other genetic changes revealed the following: a overall promoter methylation was higher in more advanced stage of the disease, b promoter methylation of RARB and BRCA1 predicted worse prognosis, and c the HIC1 promoter methylation was frequently seen in association with microsatellite instability. Promoter methylation was associated with gene silencing in CC cell lines. Treatment with methylation or histone deacetylation-inhibiting agents resulted in profound reactivation of gene expression. Conclusions These results may have implications in understanding the underlying epigenetic mechanisms in CC development, provide prognostic indicators, and identify important gene targets for treatment.

  13. Prevalence and clinical impact of sensitization to latex and fruits in dentistry students at the University of Antioquia, and its relationship with allergy to fruits

    Directory of Open Access Journals (Sweden)

    Echenique Manrique, Alejandro

    2015-04-01

    Full Text Available Objective: To determine the prevalence and clinical impact of sensitization to latex and to five tropical fruits (banana, avocado, kiwi, pineapple and passion fruit in dentistry students. Methods: Analytical cross-sectional study of 128 dentistry students at University of Antioquia in Medellín, Colombia. Information was collected by means of a questionnaire and skin prick tests with latex and fruits were done. Results: All students reported having had contact with latex. Nine of them informed at least one episode of adverse reaction to contact with latex without proof of sensitization to it. Five reported at least one reaction with one of the fruits, but skin prick tests were negative. Four of the 14 students who reported gastrointestinal symptoms were sensitized to latex or to one of the tested fruits. Overall, latex sensitization rate was 3.1%. Conclusion: This percentage of sensitization to latex is lower than that in other studies; this may be due to the expression of immune mechanisms other than IgE mediation. We failed to demonstrate a higher sensitization rate to latex as students advanced in their career. The association between gastrointestinal symptoms and sensitization to both fruit and latex is to be emphasized.

  14. The relationship of violent fathers, posttraumatically stressed mothers and symptomatic children in a preschool-age inner-city pediatrics clinic sample.

    Science.gov (United States)

    Schechter, Daniel S; Willheim, Erica; McCaw, Jaime; Turner, J Blake; Myers, Michael M; Zeanah, Charles H

    2011-12-01

    This study aims to understand if greater severity of maternal posttraumatic stress symptoms (PTSS), related to maternal report of interpersonal violence, mediates the effects of such violence on (a) child PTSS as well as on (b) child externalizing and internalizing symptoms. Study participants were mothers (N = 77) and children 18 to 48 months recruited from community pediatric clinics. Data were analyzed continuously via bivariate correlations and then multiple linear regression. Post hoc Sobel tests were performed to confirm mediation. Paternal violence accounted for 15% of the variance of child PTSS on the PCIP-OR (β = .39, p ≤ .001). While the child's father being violent significantly predicts child PTSS related to domestic violence, as mentioned, when maternal PTSS is included in the multiple regression model, father's being violent becomes less significant, while maternal PTSS remains strongly predictive. Sobel tests confirmed that maternal PTSS severity mediated effects of paternal violence on clinician-assessed child PTSS as well as on maternal report of child externalizing and internalizing symptoms. When presented with a preschool-aged child who is brought to consultation for behavioral difficulties, dysregulated aggression, and/or unexplained fears, clinicians should evaluate maternal psychological functioning as well as assess and treat the effects of interpersonal violence, which otherwise may be avoided during the consultation.

  15. Medical claims-based case–control study of temporal relationship between clinical visits for hand syndromes and subsequent diabetes diagnosis: implications for identifying patients with undiagnosed type 2 diabetes mellitus

    Science.gov (United States)

    Hou, Wen-Hsuan; Li, Chung-Yi; Chen, Lu-Hsuan; Wang, Liang-Yi; Kuo, Li-Chieh; Kuo, Ken N; Shen, Hsiu-Nien; Chiu, Chang-Ta

    2016-01-01

    Objectives To investigate whether a temporal relationship is present between clinical visits for diabetes-related hand syndromes (DHSs) and subsequent type 2 diabetes mellitus (T2DM) diagnosis and, accordingly, whether DHSs can be used for identifying patients with undiagnosed T2DM. Design This study had a case–control design nested within a cohort of 1 million people from the general population, which was followed from 2005 to 2010. The odds of prior clinical visits for DHSs, namely carpal tunnel syndrome (CTS), flexor tenosynovitis, limited joint mobility and Dupuytren's disease, were estimated for cases and controls. We used a conditional logistic regression model to estimate the OR and 95% CI of T2DM in association with a history of DHSs. The validity and predictive value of using the history of DHSs in predicting T2DM diagnosis were calculated. Setting Taiwan National Health Insurance medical claims. Participants We identified 33 571 patients receiving a new diagnosis of T2DM (cases) between 2005 and 2010. Each T2DM case was matched with 5 controls who had the same sex and birth year and were alive on the date of T2DM diagnosis. Primary and secondary outcome measures The primary outcome measure was T2DM diagnosis. Results The OR of T2DM in association with prior clinical visits was significantly increased for overall DHS and CTS, being 1.15 (95% CI 1.10 to 1.20) and 1.22 (95% CI 1.16 to 1.29), respectively. Moreover, 11% of patients with T2DM made clinical visits for CTS within 3 months prior to T2DM diagnosis. The history of DHSs had low sensitivity (<0.1% to 5.2%) and a positive predictive value (9.9% to 11.7%) in predicting T2DM. Conclusions Despite the unsatisfactory validity and performance of DHSs as a clinical tool for detecting patients with undiagnosed T2DM, this study provided evidence that clinical visits for DHSs, particularly for CTS, can be a sign of undiagnosed T2DM. PMID:27798003

  16. Temporal changes in biomarkers and their relationships to reperfusion and to clinical outcomes among patients with ST segment elevation myocardial infarction.

    Science.gov (United States)

    van Diepen, Sean; Alemayehu, Wendimagegn G; Zheng, Yinggan; Theroux, Pierre; Newby, L Kristin; Mahaffey, Kenneth W; Granger, Christopher B; Armstrong, Paul W

    2016-10-01

    Coronary plaque rupture mediating acute ST segment elevation myocardial infarction (STEMI) is associated with a systemic inflammatory response. Whether early temporal changes in inflammatory biomarkers are associated with angiographic and electrocardiographic markers of reperfusion and subsequent clinical outcomes is unclear. In the APEX-AMI biomarker substudy, 376 patients with STEMI had inflammatory biomarkers measured at the time of hospital presentation and 24 h later. The primary outcome was the 90-day composite of death, shock, or heart failure. Secondary reperfusion outcomes were (1) worst least residual ST segment elevation (ST-E: <1 mm, 1 to <2 mm, ≥2 mm) and (2) post-percutaneous coronary intervention (PCI) TIMI flow grade (0/1/2 vs 3) and TIMI myocardial perfusion grade (TMPG 0/1 vs 2/3). The 90-day incidence of death, shock or heart failure was 21.3 % in this cohort. Electrocardiographic reperfusion (worst residual ST-E <1 mm, 1 to <2 mm, ≥2 mm) was associated with differences in 24 h change in N-terminal proB-type natriuretic peptide (NT-proBNP) (1192.8, 1332.5, 1859.0 ng/mL; p = 0.043) and the pro-inflammatory cytokines Interleukin (IL)-6 (14.0, 13.6, 22.1 pg/mL; p = 0.016), IL-12 (-0.5, -0.9, -0.1 pg/mL; p = 0.013), and tumor necrosis factor α (TNFα) (1.0, 0.6, 3.6 pg/mL; p = 0.023). Angiographic reperfusion (TMPG 0/1 vs 2/3) was associated with changes in median NT-proBNP (2649.3, 1382.7 ng/mL; p = 0.002) and IL-6 (28.7, 15.1; p = 0.040). After adjustment for baseline covariates, the 24 h change in the pro-inflammatory cytokine TNFα [hazard ratio (HR) 0.49; 95 % CI 0.26-0.95; p = 0.035] and the anti-inflammatory cytokine IL 10 (HR 1.41; 95 % CI 1.06-1.87; p = 0.018) were independently associated with the primary composite outcome. Successful coronary reperfusion was associated with less systemic inflammatory response and greater temporal inflammatory changes were independently associated with higher 90-day

  17. Measuring the extent of total thyroidectomy for differentiated thyroid carcinoma using radioactive iodine imaging: relationship with serum thyroglobulin and clinical outcomes.

    Science.gov (United States)

    Holsinger, F Christopher; Ramaswamy, Uma; Cabanillas, Maria E; Lang, Juntian; Lin, Heather Y; Busaidy, Naifa L; Grubbs, Elizabeth; Rahim, Sania; Sturgis, Erich M; Lee, Jeffrey E; Weber, Randal S; Clayman, Gary L; Rohren, Eric M

    2014-05-01

    IMPORTANCE Despite performing total thyroidectomy (TT), postoperative radioactive iodine (RAI) imaging often demonstrates the presence of residual thyroid tissue within the operative bed. OBJECTIVE To measure the extent of TT using postoperative RAI imaging and assessing serum thyroglobulin (Tg) level for patients with differentiated thyroid carcinoma (DTC). DESIGN, SETTING, AND PARTICIPANTS We evaluated 245 patients undergoing TT for clinically staged cT1-3N0M0 DTC, who underwent diagnostic postoperative RAI imaging. INTERVENTIONS Total thyroidectomy. MAIN OUTCOMES AND MEASURES On the basis of quantitative measurements, RAI uptake (RAIU) in the thyroid bed of 0.2% of administered activity was selected as the cutpoint to determine the presence or absence of thyroid remnant. RESULTS By postoperative RAI imaging, TT in 106 patients (43%) resulted in RAIU of less than 0.2%. In the remaining 139 patients (57%), there was measurable iodine-avid thyroid tissue and/or tumor in the thyroid bed (n = 117 [84%]), the neck (n = 4 [3%]), or both (n = 18 [13%]). For the entire study population, mean 24-hour RAIU was 0.62%. Stimulated serum Tg levels were obtained in 232 of 245 patients (95%). Measurable stimulated Tg level (≥1 ng/mL) (to convert to micrograms per liter, multiply by 1) was found in 26 of 102 patients (25%) without thyroid remnant and in 87of 133 patients (65%) with thyroid remnant (P < .001). CONCLUSIONS AND RELEVANCE A goal of postthyroidectomy RAIU of less than 0.2% helps maximize the likelihood of an unmeasurable postoperative Tg level, potentially simplifying follow-up evaluation and reducing the use of postoperative RAI in order to facilitate surveillance.

  18. EGFR Mutations in Surgically Resected Fresh Specimens from 697 Consecutive Chinese Patients with Non-Small Cell Lung Cancer and Their Relationships with Clinical Features

    Directory of Open Access Journals (Sweden)

    Yuanyang Lai

    2013-12-01

    Full Text Available We aimed to reveal the true status of epidermal growth factor receptor (EGFR mutations in Chinese patients with non-small cell lung cancer (NSCLC after lung resections. EGFR mutations of surgically resected fresh tumor samples from 697 Chinese NSCLC patients were analyzed by Amplification Refractory Mutation System (ARMS. Correlations between EGFR mutation hotspots and clinical features were also explored. Of the 697 NSCLC patients, 235 (33.7% patients had tyrosine kinase inhibitor (TKIs sensitive EGFR mutations in 41 (14.5% of the 282 squamous carcinomas, 155 (52.9% of the 293 adenocarcinomas, 34 (39.5% of the 86 adenosquamous carcinomas, one (9.1% of the 11 large-cell carcinomas, 2 (11.1% of the 18 sarcomatoid carcinomas, and 2 (28.6% of the 7 mucoepidermoid carcinomas. TKIs sensitive EGFR mutations were more frequently found in female patients (p < 0.001, non-smokers (p = 0.047 and adenocarcinomas (p < 0.001. The rates of exon 19 deletion mutation (19-del, exon 21 L858R point mutation (L858R, exon 21 L861Q point mutation (L861Q, exon 18 G719X point mutations (G719X, including G719C, G719S, G719A were 43.4%, 48.1%, 1.7% and 6.8%, respectively. Exon 20 T790M point mutation (T790M was detected in 3 squamous carcinomas and 3 adenocarcinomas and exon 20 insertion mutation (20-ins was detected in 2 patients with adenocarcinoma. Our results show the rates of EGFR mutations are higher in all types of NSCLC in Chinese patients. 19-del and L858R are two of the more frequent mutations. EGFR mutation detection should be performed as a routine postoperative examination in Chinese NSCLC patients.

  19. The relationship between psychological contract and the satisfaction of recruitment commitment among clinical nurses%临床护士心理契约与招聘承诺实现满意度关系的研究

    Institute of Scientific and Technical Information of China (English)

    刘晓丹; 吴世菊; 彭宇阁; 宫健美

    2011-01-01

    Objective: To explore the relationship between psychological contract and the satisfaction of recruitment commitment among clinical nurses, and to propose targeted recruitment programs from the perspective of psychological contract.Methods:Psychological Contract Questionnaire for nurses and Satisfaction of Recruitment Commitment Questionnaire for nurses were used to investigate and the results wereanalyzed by statistical methods.Results: There was a positive relationship (P <0.01)between the developmental and real responsibility of hospital and the satisfaction of recruitment commitment of nurses.Conclusion: The commitment of developmental and real responsibility of hospital should be improved.%目的:了解护士心理契约与护士的招聘承诺实现满意度之间的关系,从心理契约的角度提出针对性的护士招聘方案.方法:采用"护士心理契约调查问卷"及"护士招聘承诺实现满意度调查问卷"对护士进行调查,并对结果进行统计分析.结果:医院的发展责任及现实责任与护士的招聘承诺实现满意度呈正相关(P<0.01).结论:医院在现实责任及发展责任方面作出的承诺有待完善.

  20. 临床护理人员情绪智力与工作绩效关系调查%Investigation on the relationship between emotional intelligence and job performance of clinical nursing staff

    Institute of Scientific and Technical Information of China (English)

    张磊; 孙晓晶; 刘堃; 张林

    2011-01-01

    [目的]了解护理人员情绪智力分布状况,探讨情绪智力与工作绩效的关系.[方法]对7所医院629名护理人员的情绪智力及工作绩效进行测量,探求情绪智力与工作绩效的关系.[结果]护理人员情绪智力整体水平较高;年龄、职称对护士情绪智力有一定影响;情绪智力4个维度与工作绩效关系密切;当情绪智力4维度全部进入回归模型时,能够解释总变异的27.6%.[结论]护理管理者应加强对临床护理人员情绪智力的培养,进一步提高工作绩效.%Objective:To know about the distribution status of emotional in telligence of nursing staffs and to probe into the relationship between emo tional intelligence and job performance. Methods: Emotional intelligence and job performance of 629 nursing staff from 7 hospitals were measured. Then the relationships between emotional intelligence and job performance were probed. Results:Emotional intelligence of nursing staff was at a high level. Age and professional title of nursing staff had some impacts on emotional in telligence. There were close relationships between four dimensions of emo tional intelligence and job performance. When all four dimensions of emotion al intelligence were considered into the regression model, emotional intelli gence could explain 27. 6% of the total variance. Conclusion:Nursing admin istrators should strengthen the cultivation of emotional intelligence of clinical nursing staff so as to enhance their job performance a step further.

  1. 人际关系对大专护生实习效果影响的质性研究%Effect of interpersonal relationship on clinical practice outcome of associate degree nursing students: A qualitative study

    Institute of Scientific and Technical Information of China (English)

    徐然; 沈军

    2014-01-01

    目的 构建适用于大专护生的人际关系内涵的诠释理论.方法 采用扎根理论研究法对10名大专生进行深度访谈,经过三级编码和反复比较,确定大专生临床实习中的人际关系内涵.结果 本研究形成的人际关系内涵,核心概念为“获得归属感”,主要受到带教老师、护士长、患者及家属、本科实习生、医生的影响.结论 根据该诠释理论,可构建和谐的临床实习人际关系,提高实习效果.%Objective To construct interpretation theory which is suitable to explain the connotation of interpersonal relationship among associate degree nursing students.Methods The data were collected through deep interviews.The content of interpersonal relationship was affirmed by three-level coding and comparing repeatedly.Results The core concept was "gaining a feeling of belonging" and it could be affected by 5 generic concepts including clinical teachers,head nurses,baccalaureate degree nursing students,patients and doctors.Conclusions Harmonious interpersonal relationship can be built according to the theory of interpretation and practice outcomes can be improved.

  2. Relationship of the sexual functions with the clinical parameters, radiological scores and the quality of life in male patients with ankylosing spondylitis.

    Science.gov (United States)

    Sariyildiz, Mustafa Akif; Batmaz, Ibrahim; Dilek, Banu; Inanir, Ahmet; Bez, Yasin; Tahtasiz, Mehmet; Em, Serda; Cevik, Remzi

    2013-03-01

    with AS. This impairment in the sexual function is especially correlated with the BASFI and BASMI among the clinical and laboratory parameters.

  3. Molecular sources of residual cardiovascular risk, clinical signals, and innovative solutions: relationship with subclinical disease, undertreatment, and poor adherence: implications of new evidence upon optimizing cardiovascular patient outcomes

    Directory of Open Access Journals (Sweden)

    Kones R

    2013-10-01

    would be cardioprotective. When LDL cholesterol is aggressively lowered to targets, low HDL cholesterol levels are still inversely related to MCVE. The efflux capacity, or ability to relocate cholesterol out of macrophages, is believed to be a major antiatherogenic mechanism responsible for reduction in MCVE mediated in part by healthy HDL. HDL cholesterol is a complex molecule with antioxidative, anti-inflammatory, antithrombotic, antiplatelet, and vasodilatory properties, among which is protection of LDL from oxidation. HDL-associated paraoxonase-1 has a major effect on endothelial function. Further, HDL promotes endothelial repair and progenitor cell health, and supports production of nitric oxide. HDL from patients with cardiovascular disease, diabetes, and autoimmune disease may fail to protect or even become proinflammatory or pro-oxidant. Mendelian randomization and other clinical studies in which raising HDL cholesterol has not been beneficial suggest that high plasma levels do not necessarily reduce cardiovascular risk. These data, coupled with extensive preclinical information about the functional heterogeneity of HDL, challenge the “HDL hypothesis”, ie, raising HDL cholesterol per se will reduce MCVE. After the equivocal AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health Outcomes study and withdrawal of two major cholesteryl ester transfer protein compounds, one for off-target adverse effects and the other for lack of efficacy, development continues for two other agents, ie, anacetrapib and evacetrapib, both of which lower LDL cholesterol substantially. The negative but controversial HPS2-THRIVE (the Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events trial casts further doubt on the HDL cholesterol hypothesis. The growing impression that HDL functionality, rather than abundance, is clinically important is supported by experimental evidence highlighting

  4. Molecular sources of residual cardiovascular risk, clinical signals, and innovative solutions: relationship with subclinical disease, undertreatment, and poor adherence: implications of new evidence upon optimizing cardiovascular patient outcomes.

    Science.gov (United States)

    Kones, Richard

    2013-01-01

    cholesterol levels are still inversely related to MCVE. The efflux capacity, or ability to relocate cholesterol out of macrophages, is believed to be a major antiatherogenic mechanism responsible for reduction in MCVE mediated in part by healthy HDL. HDL cholesterol is a complex molecule with antioxidative, anti-inflammatory, anti-thrombotic, antiplatelet, and vasodilatory properties, among which is protection of LDL from oxidation. HDL-associated paraoxonase-1 has a major effect on endothelial function. Further, HDL promotes endothelial repair and progenitor cell health, and supports production of nitric oxide. HDL from patients with cardiovascular disease, diabetes, and autoimmune disease may fail to protect or even become proinflammatory or pro-oxidant. Mendelian randomization and other clinical studies in which raising HDL cholesterol has not been beneficial suggest that high plasma levels do not necessarily reduce cardiovascular risk. These data, coupled with extensive preclinical information about the functional heterogeneity of HDL, challenge the "HDL hypothesis", ie, raising HDL cholesterol per se will reduce MCVE. After the equivocal AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health Outcomes) study and withdrawal of two major cholesteryl ester transfer protein compounds, one for off-target adverse effects and the other for lack of efficacy, development continues for two other agents, ie, anacetrapib and evacetrapib, both of which lower LDL cholesterol substantially. The negative but controversial HPS2-THRIVE (the Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events) trial casts further doubt on the HDL cholesterol hypothesis. The growing impression that HDL functionality, rather than abundance, is clinically important is supported by experimental evidence highlighting the conditional pleiotropic actions of HDL. Non-HDL cholesterol reflects the cholesterol in all

  5. 临床护士心理护理使用频率与工作环境的相关性分析%Analysis on the relationship of psychological care use frequency and work environment in clinical nurses

    Institute of Scientific and Technical Information of China (English)

    李重先

    2016-01-01

    Objective To survey the situation of the psychological care frequency and the work envi-ronment,then to study the relationship between both. Methods Author surveyed 200 clinical nurses in questionnaire by using the Clinical Psychology Nursing Scale-Nurse (CNPS-N) and Practice Environme- nt Scale (PES). Results The score of the general psychological care was 3.84 ±0.51,and the professional psychological care was 2.96±0.41. The average score of the work environment was 2.78±0.24. There was a positive relationship between the situation of the psychological nusing frequency and the work environment (P<0.05). Conclusion The related psychological knowledge training should be given by the nursing administrators so as for increasing the psychological care frequency.%目的:调查护士实施心理护理频率及工作环境现状,并研究两者之间的关系。方法采用临床心理护理量表(护士用)(Clinical Psychology Nursing Scale-Nurse,CNPS-N)和中文版护理工作环境量表(Practice Environment Scale,PES)对200名护士进行问卷调查。结果临床护士在工作中使用一般心理护理得分为3.84±0.51,专业心理护理的得分为2.96±0.41。护士工作环境总分平均为2.78±0.24。护士工作环境与心理护理使用频率呈正相关(P<0.05)。结论临床护理管理者应有针对性的加强护士心理护理知识的相关培训,采取措施改善护士工作环境,以提高护士实施心理护理的频率。

  6. Study on the Relationship Between TCM Syndrome Types and Common Clinical Indexes of Knee Osteoarthritis%膝骨关节炎中医证型与常见临床指标之间的关系研究

    Institute of Scientific and Technical Information of China (English)

    潘雪; 王伟钢

    2016-01-01

    目的:通过对既往病例的研究,运用统计方法观察膝骨关节炎中医辨证分型与常见临床指标如C-反应蛋白、红细胞沉降率、X线检查之间的关系,为临床工作提供新的参考。方法:选取115例膝骨关节炎患者归档病历作为研究对象,依据证候诊断标准对患者进行辨证分型,统计膝骨关节炎的证型分布规律,并分析膝骨关节炎患者中医辨证分型与临床观察指标之间的关系。结果:①构成比:风寒湿痹证占46.96%(54/115),风湿热痹证占13.04%(15/115),瘀血痹阻证占25.22%(29/115),肝肾亏虚证占14.78%(17/115)。②各证型临床指标之间的差异均无统计学意义(P >0.05),风湿热痹证的C-反应蛋白和红细胞沉降率及瘀血痹阻证的C-反应蛋白均值较高,肝肾亏虚证的影像学分级较高。结论:常见临床指标如C-反应蛋白、红细胞沉降率、X线检查等可以为膝骨关节炎的中医辨证分型提供一定的依据。%Objective:By studying previous cases to observe the relationship between TCM Syndrome Types and common clinical indexes of knee osteoarthritis such as C-reactive protein,erythrocyte sedimentation rate and X-ray examination in order to provide a new reference for clinical work.Methods:A syndrome differentiation-classiifcation was made for archived 115 cases of knee osteoarthritis,making the syndrome distribution statistics of knee osteoarthritis and analyzing the relationship between TCM Syndrome Types and common clinical indexes. Results:①The constituent ratio:Wind-cold-damp bi syndrome accounted for 46.96%(54/115),rheumatic fever bi syndrome accounted for 13.04%(15/115),blood stasis bi syndrome accounted for 25.22%(29/115),and liver and kidney deficiency syndrome accounted for 14.78%(17/115).②The differences between various types of clinical indicators were not statistically significant(P> 0.05).C-reactive protein and erythrocyte

  7. 护患关系对临床护士职业倦怠的影响%lnfluence of nurse-patient relationship on job burnout of clinical nurses

    Institute of Scientific and Technical Information of China (English)

    和树芸

    2015-01-01

    Objective:To explore the influence of nurse-patient relationship on job burnout of clinical nurses so as to put forward the corresponding countermeasures. Methods:450 clinical nurses were investigated by using the general questionnaire for nurses and the job burnout inventory ( MBI-HSS) . Results:The factors influencing the detection rate of job burnout of nurses were:the self-assessment of nurse′s worKing environment,the degree of patient′s trust and respect;the factors influencing the score of each dimension were:the self-assessment of nurse′s worKing environment,the degree of patient's trust and respect and the patient's satisfaction with nursing service ( P<0. 05);the higher the scores were,the heavier the degree of job burnout was (P<0. 05). Conclusion:The nurse-patient relationship is one of important factors influencing job burnout of clinical nurses,so hospital managers should focus on building a good nurse-patient re-lationship and good worKing environment and looKing for positive countermeasures from three aspects of individual,organization and society to prevent and reduce the occurrence of job burnout of nurses.%目的::探讨护患关系对临床护士职业倦怠的影响,并提出相应的对策。方法:采用护士调查问卷和马氏职业倦怠量表( MBI-HSS)调查450名临床护士,分析不同护患关系对临床护士职业倦怠的影响。结果:影响护士职业倦怠检出率的因素是:护士执业环境自评状况、患者信任度、患者尊重度;影响各维度得分因素有:护士执业环境自评状况、患者信任度、患者尊重度、患者服务满意度,其中,执业环境自评好、患者信任度高、患者尊重度高的护士,情感衰竭、去人格化得分较低,职业倦怠程度轻(P<0.05);得分越高,其职业倦怠程度越重(P<0.05)。结论:护患关系是影响临床护士职业倦怠的重要因素,医院管理者应注重构建良好的护患关系和执

  8. Analysis of relationship between occupational stress and burnout of the clinical nurses in Changsha%长沙市临床护士职业压力与职业倦怠的相关性研究

    Institute of Scientific and Technical Information of China (English)

    席明霞; 卿利敏; 李丹; 黄冬枚

    2012-01-01

    目的 探讨长沙市临床护士职业压力与职业倦怠的关系,为医院临床护理管理者预防和干预临床护士职业压力和职业倦怠提供依据.方法 采用临床护士一般资料调查表、职业压力问卷和职业倦怠问卷对长沙市5所综合性医院的412名临床护士进行问卷调查.结果 临床护士职业压力总均分为(3.77±0.48)分,其中人际关系得分为(3.93±0.56)分居首位;职业倦怠总均分为(3.82±0.40)分,其中情感衰竭得分为(3.27±0.58)分居首位,职业压力和职业倦怠均处于高水平;低成就感与职业压力及其患者态度和职业发展维度呈正相关(P<0.05),情感衰竭与职业压力及其人际关系、患者态度、危重患者、职业发展维度呈正相关(P<0.05),职业倦怠及其人格解体维度与职业压力及其各维度均呈正相关(P<0.05).结论 长沙市临床护士的职业压力和职业倦怠均处于高水平,应引起医院管理者和社会的重视.%Objective To explore the relationship between occupational stress and the job burnout of clinical nurses in Changsha so as to provide the reference of prevention and intervention of occupational stress and the job bumout for the managers in hospitals. Methods A total of 412 clinical nurses in 5 general hospitals were recruited, and a general information questionnaire, Occupational Stress Scale and job Bumout Scale were employed. Results The mean score of occupational stress was (3.77 ± 0. 48) and the highest was the dimension of interpersonal relationship (3. 93 ± 0. 56). The mean score of job bumout was (3.82 ±0.40) and the highest was the dimension of emotional exhaustion (3.27 ±0.58). The scores of occupational stress and job bumout were at a high level. The score of low accomplishment was positively correlated with the occupational pressure (P < 0.05), and the score of emotional exhaustion was positively correlated with interpersonal relationship,patients'attitude,patients with

  9. 医患关系紧张情况下的临床超声教学策略思考%Clinical teaching strategies under the context of tense doctor-patient relationship

    Institute of Scientific and Technical Information of China (English)

    陈钰仪; 张学群; 赵萍; 曾燕静

    2014-01-01

    医患关系是目前医疗社会关系中重点关注内容,医患关系紧张直接影响了医疗行业的从业及医疗人才的培养。临床带教是医药人才培养的关键阶段,为了适应医患关系紧张的现状,避免实习医疗事故及医疗纠纷的发生,防止医患暴力冲突的演变,我们从实际临床带教出发,从加强学生上机操作前的培训,加强职业语言艺术的培养,加强教师带教及实习生制度管理,加强职业道德教育与人格培养,加强法制教育,以及加强保护与自我保护6个方面进行了教学策略探讨。%The doctor-patient relationship has become a major concern of medical social relations . The tension between doctors and patients has a direct impact on employment and training of medical personnel in medical industry .Clinical teaching is a key stage of medical personnel training .In order to adapt to the tense doctor-patient relationship , avoid medical accidents and medical disputes during internship , and prevent violent conflicts between doctors and patients , this paper discusses the practice teaching strategies based on our actual practice: strengthening training for students before computer operation , strengthening training of students 'professional language art , strengthening regulation of teachers and interns , strengthening students'professional ethical education and personality training , strengthening legal education , and strengthening students'protection and self-protection training .

  10. TP、VEGF在结直肠癌中的表达及临床病理研究%The expression of TP, VEGF and its relationship with clinical Pathological significance in Colorectal Cancer

    Institute of Scientific and Technical Information of China (English)

    夏传生; 李娜萍; 吴纯东; 王义松; 王书刚

    2011-01-01

    目的 探讨胸苷磷酸化酶(TP)、血管内皮生长因子(VEGF)的表达及其与结直肠癌临床病理特征的关系.方法 应用免疫组织化学EnVision TM法检测88例结直肠癌组织中TP、VEGF的表达,结合临床病理特征进行分析.结果 正常结直肠黏膜上皮不表达TP和VEGF;TP表达于结直肠癌细胞和(或)间质内单个核细胞,VEGF表达于癌细胞.TP和VEGF的阳性表达率分别为42.05%(37/88)和23.86%(21/88).TP和VEGF在淋巴结转移及Duke's Ⅲ-Ⅳ期患者中的阳性率高于无淋巴结转移及Duke'sⅠ-Ⅱ期患者(P<0.05);TP阳性表达率在癌组织浸润至浆膜及浆膜外组高于浸润程度较浅组(P<0.05).结论 TP和VEGF的异常表达可能促进结直肠癌的浸润与转移.%Objective To investigate the expression of thymidine phosphorylase(TP) and vascular endothelial growth factor (VEGF) and its relationship with clinical pathological charucteristies of colorectal cancer. Metods Immunohistochemical staining method EnVision TM was used to investigate the expression of TP and VEGF in 88 cases of colorectal cancer and its relationship with clinical pathology . Results TP and VEGF were not expressed in normal colorectal mucosa, but TP expression in cancer tissue was observed in both cancer cells and (or) single nucleus cells of the mesenchyme. VEGF expression in cancer tissue was observed in the cancer cells. The positive expression rate of TP and VEGF was 40. 05% (37/88) and 23. 86% (21/88) respectively in colorectal cancer. Higher in the cases of lymph node metastasis and Duke,s Ⅲ-Ⅳ than in those without lymph node metastasis and Duke,s Ⅰ-Ⅱ (P<0.05). The positive expression rate of TP was higher in the cancer tissue invading the serosa and beyond (P<0. 05). Conclusion The anomalous expression of TP and VEGF in colorectal cancer may promote the invasion and metastasis of colorectal cancer.

  11. Clinical grades: upward bound.

    Science.gov (United States)

    Walsh, Catherine M; Seldomridge, Lisa A

    2005-04-01

    This study examined the relationship of grades earned in paired theory and clinical courses. Data collected during academic years 1997 to 2002 confirmed that grade inflation exists in clinical nursing courses. Problems involved in awarding grades for clinical performance are discussed (e.g., standards of clinical performance, methods used in evaluation of clinical performance, the impossibility of faculty omnipresence, the influence of student effort in grading, the effect of recency, the challenges of keeping good anecdotal records). Solutions to grading problems are proposed, including dividing up performance into agreed-on elements, measurement of these elements on a grading scale that allows for more differentiation of quality in evaluating clinical performance, assigning grades from the beginning of a clinical course, emphasizing all three domains of clinical practice, and evaluating student performance in both laboratory and, clinical settings.

  12. 青壮年低钾血症心电图改变与临床病因关系%Relationship Between Electrocardiogram Change and Clinical Etiology of Hypokalemia in Young Adults

    Institute of Scientific and Technical Information of China (English)

    伏忠阳; 和勇

    2009-01-01

    目的 探讨青壮年低钾血症患者心电图改变与临床病因关系.方法 将104例青壮年患者的心电图改变与临床病因及血清钾浓度作对比分析.结果 青壮年低钾血症患者心电图异常改变80例(76.92%),其中以U波增高80例(76.92%)、ST段改变64例(61.54%)、T波改变62例(59.62%);心电图异常发生率随血清钾浓度的降低而呈递增.结论 青壮年低钾血症患者的病因以原发疾病造成的钾摄入不足为主,随着血钾浓度的降低,心电图异常发生率增加,改变随之加重.%Objective To probe the relationship between electrocardiogram (ECG) change and clinical etiology of hypokalemis in young adult patients. Methods Contrast and analyze ECG change, clinical etiology and serum potassium concentration of 104 cases of young adult patients. Results 80 cases (76.92%) of young adult hypokalemia patients' ECG were changed abnormally. Among them, U wave value of 80 cases (76.92%) were raised and ST segment of 64 ca-ses (61.54%) and T wave of 62 cases (59.62%) were changed. The rate of ECG abnormity increased with the decrease of serum potassium concentration. Conclusion The main cause of hypokalemia in young adult patients is insufficient in-take of potassium caused by primary diseases The rate of ECG abnormity increases and the ECG change becomes worse with the decrease of serum potassium concentration.

  13. The level of learning motivation and teacher-student relationship among nursing students during clinical practice%护理实习学生学习动机和师生关系的研究

    Institute of Scientific and Technical Information of China (English)

    任艳; 胡晓莹

    2012-01-01

    目的 调查护理实习学生的学习动机和师生关系状况,探讨其影响因素,并分析两者的关系.方法 采用方便抽样法,抽取江西省3家三级甲等医院的护理实习学生489名为对象,应用一般情况调查表、师生关系问卷、学习动机量表对其进行问卷调查.结果 学习动机各维度评分为:深层动机(3.52±0.55)分,成就动机(3.33±0.57)分,表层动机(3.10±0.49)分;亲密性为深层动机、学习动机最强影响因子;支持性为成就动机最强影响因子;择业意向对深层动机、成就动机有预测作用.师生关系各维度评分为;支持性(3.68:±0.75)分,满意性(3.62±0.66)分,亲密性(3.21±0.69)分,冲突性(1.63±0.52)分;表层动机对师生关系有负向预测作用,是支持性、冲突性的重要预测因子;成就动机、深层动机对师生关系有较强的正向预测作用,其中,深层动机是支持性、满意度、亲密性和冲突性的重要预测因子,成就动机是支持性的重要预测因子;择业意向、亲属从医情况、医院性质、年龄、学历对师生关系也有较强的预测作用.结论 护理实习学生的师生关系和学习动机受多种因素影响,师生关系和学习动机是相互促进的,培养护理学生学习兴趣和构建融洽师生关系是必要的.%Objective To investigate the level of learning motivation and teacher-student relationship among nursing students during clinical practice,and to analyze their influencing factors, and the relationship. Methods Totally 489 nursing students were recruited from three 3-A hospitals in Jiangxi province. They were investigated by using Learning Motivation Scale and Teacher-Student Relationship Questionnaire. Results The factor scores of learning motivation were ranked as deep motivation (3.52±0.55),achievement motivation(3.33±0.57) and superficial motivation(3.10±0.49). Intimacy was the strongest influencing factor of deep motivation and general learning

  14. Discuss how to establish a good relationship between nurses and patients in clinical nursing work%浅谈如何在临床护理工作中建立良好的护患关系

    Institute of Scientific and Technical Information of China (English)

    段鹏飞; 闫立云; 赵福成

    2015-01-01

    Nursing staff in daily clinical nursing work, patients with all kinds of physical and mental disorders, and needs to build a good relationship between nurse and patients to ensure treatment process smoothly. Only has established the good relations between nurses and patients, patients' trust, to better meet the needs of the patients with a variety of, to provide high quality nursing service, truly achieve the goal of promote patients recover.%护理人员在从事日常临床护理工作中,出于其工作性质的特点以及需要服务的护理对象,护理人员需要与患有各类身心疾患的患者建立起良好的护患关系,以此确保治疗过程的顺利进行。只有建立了良好的护患关系,取得患者信任,才可更好的满足患者各种需要,为其提供真正优质的护理服务,达到促进患者康复的目的。

  15. Relationship Between Personality Types Conceptualized by C. G. Jung and Emotional Intelligence

    OpenAIRE

    Natasha Virmozelova; Mariana Dimitrova

    2013-01-01

    The main aim of this study is to present the results from a study of the relationship between personality types described by C. G. Jung and emotional intelligence. The investigated subjects were 150 at the age of 18 – 50. The methods of research were MBTI (Myers-Briggs Type Indicator) - Bulgarian adaptation (Rusinova, 1992) and one psychological questionnaire measuring emotional intelligence -Bulgarian adaptation (Stoyanova, 2008). The received data indicated that the functions of thinking an...

  16. 抑郁症患者5-羟色胺与中医证型及症状关系分析%Analysis on Relationship between TCM Syndrome Types, Clinical Symptoms and 5-HT Level of Major Depression Patients

    Institute of Scientific and Technical Information of China (English)

    崔宁; 李跃华; 孙锦锦; 许大剑; 汪振杰; 杨慧敏; 陈小平

    2013-01-01

    目的 探讨抑郁症患者5-羟色胺(5-HT)水平及与其相应的中医证型、症状的相关性.方法 采用病例对照研究的方法,共观察抑郁症患者210例,进行中医辨证及证候指标调查,分析各组5-HT的差异及中医证型、症状与5-HT的关系.结果 210例抑郁症患者外周血5-HT功能与正常对照组差异有统计学意义(P<0.01),外周血5-HT低下者各中医证型之间比较,差异无统计学意义(P>0.05),5-HT功能低下的抑郁症患者核心症状及其他症状分布情况与5-HT功能不低下的患者比较,差异有统计学意义(P<0.01).结论 5-HT功能对抑郁症发病以及中医证型、症状有一定影响.%Objective To investigate the relationship of TCM syndromes, clinical symptoms and 5-HT level of major depression (MD) patients. Methods With case-control method, 210 MD patients were investigated. TCM diagnosis and syndrome indicators were observed. The differences in 5-HT of each group, and the relationship between TCM diagnosis, syndrome indicators and 5-HT were analyzed. Results The 5-HT level of MD patients was different with normal control (P0.05). There was difference in core symptoms and other symptoms of patients with different 5-HT level (P<0.01). Conclusion The level of 5-HT has influence on TCM syndromes and symptoms of MD patients.

  17. Relationship between clinical biochemical detection indexes of fatty liver and related effect factors%脂肪肝临床生化检测指标与影响因素间的关系研究

    Institute of Scientific and Technical Information of China (English)

    刘宁

    2015-01-01

    Objective To investigate the relationship between the clinical biochemical detection indexes of fatty liver and related effect factors .Methods A total of 73 fatty liver patients from April 2013 to April 2014 were select‐ed as the observation group ,and another 80 healthy persons were selected as the healthy control group .The related clinical biochemical indexes were detected ,and the clinical basic materials of them were observed .Results The levels of triacylglycerol ,total cholesterol ,alanine aminotransferase ,aspartate transaminase ,cholinesterase ,total bile acid ,to‐tal bilirubin in the observation group were significant higher than those of the healthy control group ,the differences were statistical significant(P< 0 .05) .Further more ,the incidence rate of obesity ,high blood pressure ,high blood sugar and high cholesterol ratios of the observation group were significantly higher than those of the healthy control group ,and the behaviors of limiting alcohol consumption ,regular exercise ,limit high‐fat food and regular medical ex‐aminations ratios were significant less than those of the healthy control group ,the differences were statistical signifi‐cant(P<0 .05) .Conclusion The clinical lipids and liver function biochemical indexes detection has good diagnosed value for the fatty liver ,and the reasonable intervention of the related factors is helpful to the improvement of bio‐chemical indexes ,which has good prevention and cured effects for this disease .%目的:探讨脂肪肝的相关生化检测指标与其影响因素的相关性。方法选取该院2013年4月至2014年4月收治的脂肪肝患者73例作为观察组,同期选取80例健康体检者作为健康对照组,分别对两组开展相关生化指标检测,同时观察患者临床基本资料。结果观察组患者三酰甘油、总胆固醇、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、胆碱酯酶、总胆汁酸、总胆红素检测结果

  18. 探讨全血白细胞计数危急值与临床的相互关系%Investigation of the relationship between whole blood leukocyte counts and clinical critical values

    Institute of Scientific and Technical Information of China (English)

    李芳林

    2015-01-01

    AIM:To investigate the relationship between critical value blood leukocyte counts and clinical practice.METHODS:From June 2011 to May 2013 in our hospital all critical values, detected by medical laboratory,were selected and analyzed retro-spectively including the clinical data of whole blood cell count in patients with critical values,and patients'characteristics and dis-tribution.RESULTS:A total of 1 462 reported values matched the critical value critical condition,82 critical values of whole blood leukocyte count,81 540 count tests in total,and whole blood leukocyte count was reported critical values of 0.10%,ac-counting for 5.61% of the total critical value;whole blood leuko-cyte count critical values were mainly in leukemia,acute infec-tions,and cancer;high values of critical values distributed in 59 cases of acute infection,leukemia,acute bleeding,burns,canc-er,and kidney failure patients,with the distribution interval being (30.1 ~310.0)×109 /L;the low critical value distributed in 23 cases of leukemia and cancer patients,with the distribution range being (0.04 ~0.50)×109 /L.CONCLUSION:Quoted rate of white blood cell count can be affected by its critical value range, therefore the whole range of critical white blood cell count should be reasonably set,and its distribution characteristics should be analyzed and timely fedback to the clinic,in order to offer better clinical services.%目的:探讨全血白细胞计数危急值与临床的相互关系.方法:选取2011-06/2013-05我院医学检验科检测到的所有危急值,对全血白细胞计数危急值患者的临床资料进行回顾性分析,包括患者的特点和分布情况.结果:共报出符合危急值报告条件的危急值1462个,全血白细胞计数危急值82个,共进行全血白细胞计数测试81540个,全血白细胞计数危急值报出率为0.10%,占总危急值的5.61%;全血白细胞计数危急值主要分布在白血病、急性感染、

  19. 77 FR 49448 - Food and Drug Administration Clinical Trial Requirements, Compliance, and Good Clinical Practice...

    Science.gov (United States)

    2012-08-16

    ... interaction with FDA representatives. The program will focus on the relationships among FDA and clinical trial... Pharmaceutical Clinical Trial; (3) Medical Device Aspects of Clinical Research; (4) Adverse Event...

  20. Messy Relationships

    DEFF Research Database (Denmark)

    Feldt, Liv Egholm

    “The common good” is a contested concept both presently and historically. The contestation takes place both through definitions and concrete practices of gift-giving at the messy and blurred intersection between state, marked and civil society. From the Danish constitution of 1849 until today, ph...... the messy relationship between state, market and civil society. The overall aim of this paper is through an empirical analysis of philanthropic gift-giving to show how a combination of elements from microhistory, ANT and conceptual history contribute to the study of messiness.......-giving as a continuous and negotiated process between actors whose actions and utterances have implications for the relationships between state, market and civil society. The paper first outlines a theoretical and methodological approach that connects ANT and microhistory with conceptual history and focuses on how...

  1. 人乳头状瘤病毒感染与宫颈癌发病关系的临床分析%Clinical analysis of relationship between human papillomavirus infections and cervical cancer

    Institute of Scientific and Technical Information of China (English)

    孙彦珍; 袁征; 李珍; 张子杰; 王晶璇

    2016-01-01

    OBJECTIVE To explore the relationship between the human papillomavirus (HPV) infections and cervi-cal cancer so as to provide guidance for clinical prevention of cervical cancer .METHODS The cervical cancer tissue specimens were collected from 50 patients who underwent cervical cancer biopsy or radical hysterectomy in the hospital from Jan 2012 to Dec 2014 and were assigned as the study group;the cervical tissue specimens were col-lected from 50 patients who underwent the hysteromyomectomy and were set as the control group .The prevalence of HPV infections in the two types of specimens was detected by using immunohistochemical staining method ,the correlation between the HPV infection and the clinical characteristics of cervical cancer was analyzed ,and the sta-tistical analysis of data was performed with the use of SPSS19 .0 software .RESULTS The incidence rate of HPV infection of the study group was 46 .0% ,significantly higher than 4 .0% of the control group (P<0 .05) .The a-nalysis of the relationship between the HPV infection and the characteristics of cervical cancer showed that the in-cidence rate of HPV infection was 66 .7% in the patients without amenorrhea ,significantly higher than 15 .0% in the patients with amenorrhea;the incidence rate of HPV infection of the clinical stage Ⅱ patients was 87 .5% , significantly higher than 26 .5% of the clinical stage Ⅰ patients ;the incidence rate of HPV infection of the pa-tients with lymph node metastasis was 83 .3% ,significantly higher than 25 .0% of the patients without lymph node metastasis ;the incidence rate of HPV infection of the patients with pathological histological grade 3 was 80 .0% ,significantly higher than 30 .0% of the patients with pathological histological grade 1 and 40 .0% of the patients with pathological histological grade 2 (P<0 .05) .CONCLUSION The incidence rare of HPV infection is high in the patients with cervical cancer ,and the HPV infection is closely associated with the cervical

  2. Relationship between Stressor and Self-efficacy of Nursing Undergraduates in Initial Stage of Clinical Practice%本科护生实习初期压力源与自我效能感的相关性研究

    Institute of Scientific and Technical Information of China (English)

    雷慧; 王燕

    2011-01-01

    目的 了解本科护生临床实习初期压力源与自我效能感现状及两者的相关性.方法 采用自制的本科护生临床实习压力源问卷及一般自我效能感量表对170名本科护生进行问卷调查.结果 本科护生临床实习初期压力源依次为:自身知识与技能、工作性质与内容、自身及就业、病人护理、教学组织与管理、医院环境与人际关系;一般自我效能感总均分为(2.57±0.46)分,高于中间分2.5水平;各压力源得分与自我效能感均呈负相关( r=-0.61~-0.30,P<0.001).结论 本科护生临床实习初期压力源与自我效能感呈负相关.护理教育工作者应重视培养临床实习本科护生的自我效能感,加强本科护生实习前护士职业素质及护理操作技能培训,实习中尤其是实习初期的心理支持,提高本科护生的自我效能感,以减轻临床实习压力,提高实习质量.%Objective To probe into the relation between stressors and self-efficacy of nursing undergraduates during their initial stage of clinical practice. Methods A total of 170 nursing undergraduates were surveyed with General Self-efficacy Scale (GSES)and a self-designed stressors questionnaire. Results The stressors in their initial stage of clinical practice included the followings in sequence: knowledge and skill, jobs, employment, patient nursing, teaching organization and management environment of hospital and interpersonal relationship. The score of GSES of nursing students was (2.57 ±0.46) which was above the moderate level of 2.5. There was negative correlation between each stressor and self-efficacy of nursing students (r=-0.61 ~-0.30, P<0.001). Conclusion There is negative correlation between stressors and self-efficacy of nursing undergraduates during their initial stage of clinical practice.Importance should be attached to enhance self-efficacy and professional quality of nursing of nursing students. Psychological support is expected during

  3. Clinical Significance of Establishing Relationship between the HBsAg Test and HBV DNA%乙肝五项测定结果与HBV DNA的关系及其临床意义

    Institute of Scientific and Technical Information of China (English)

    李昕; 张荣波

    2011-01-01

    Objective To explore the internal relationship and the clinical significance of HBVM( HBsAg, Anti-HBs,HBeAg,Anti-HBe, Anti-HBc )and HBV DNA( Hepatitis B Virus DNA ). Methods HBVM and HBV-DNA of 300 HBV patients were examined by enzyme linked immunosorbent assay( ELISA )and quantitative fluorescence PCR technique respectively. Results Of all the clinical results of 300 HBV patients,110 patients showed HBsAg( + ),HBeAg( + ),HBcAb( + )( HBV DNA positive rate 99. 1% ),85 patients showing HBsAg( + ), HBeAb( + ),HBcAb( + )( HBV DNA positive rate 69.4% ), 39 patients showing HBsAg( + ),HBcAb( + )( HBV DNA positive rate 53.8% ),53 patients showing HBeAb( + ),HBcAb( + )( HBV DNA positive rate 35.8% ). HBV DNA positive rate of HBsAg( + ),HBeAg( + ),HBcAb( + ) and HBsAg( + ), HBeAb( + ), HBcAb( + ) were different significantly( x2 = 35. 406, P < 0.05 ). Conclusion The results of HBsAg and HBV-DNA are closely related with different clinical meanings,which makes it necessary to combine the two results for a correct diagnosis and treatment.%目的探讨乙型肝炎(乙肝)五项结果和HBV DNA检出情况间的关系和临床意义.方法运用聚合酶链反应法检测300例乙肝血清的HBV DNA,并用酶联免疫吸附实验法进行乙肝五项的测定,对结果进行比较分析.结果 300例乙肝门诊的患者中乙肝五项的结果为110例HBsAg(+)、HBeAg(+)、HBcAb(+)(大三阳),其HBV DNA的阳性率为99.1%,85例HBsAg(+)、HBeAb(+)、HBcAb(+)(小三阳),其HBV DNA的阳性率为69.4%,39例HBsAg(+)、HBcAb(+),其HBV DNA的阳性率为53.8%,53例HBeAb(+)、HBcAb(+),其HBV DNA的阳性率为35.8%.大三阳和小三阳的HBV DNA阳性率比较差异有统计学意义(χ2=35.406,P<0.05).结论乙肝五项的结果与HBV DNA的结果有着密切的联系,并且都具备各自的临床意义,因此两者必须结合才能正确地对乙肝患者的病情作出正确分析和判断.

  4. Relationship between Family Function and Clinical Symptoms of Adolescent Patients with Somatoform Disorder%青少年躯体形式障碍患者临床症状与家庭功能的关系

    Institute of Scientific and Technical Information of China (English)

    邵云; 刘果; 王旭梅; 夏静; 战玉华; 豆立宁; 巩凯旋

    2013-01-01

    Objective To explore the relationship between family functions and clinical symptoms of adolescent patients with somatoform disorder. Methods A total of 136 middle school students with somatoform disorder were included in the study group, and 122 normal students were included in the control group. All subjects were asked to fill out the form of general information, Family Assessment Device ( FAD ) and Symptom Checklist 90 ( SCL - 90 ) . SPSS 11. 5 was used for data analysis. Results The total and factor scores of FAD ( except the factor of Roles and Affective Involvement) and SCL -90 were significantly higher in the study group than that in the control group ( P < 0. 01 ) . Except the factor of Roles, the factor scores of FAD was positively correlated with that of SCL - 90 in the study group ( P < 0. 05 ) . Conclusion Adolescent patients with somatoform disorder tend to have visible family dysfunction, which is correlated with the patients' clinical symptoms. Clinical treatment to adolescent somatoform should consider family therapy as a key component.%目的 探讨青少年躯体形式障碍患者的家庭功能状况及与临床症状的关系,为临床有效开展家庭治疗提供依据.方法 136例被临床诊断为躯体形式障碍的青少年(病例组)与122例对照者(对照组)共同完成一般资料调查表、家庭功能评定量表和症状自评量表的填写.采用SPSS 11.5统计软件对两组数据进行统计分析;采用χ2检验和t检验对病例组与对照组的一般资料进行比较;两组家庭功能评定量表及症状自评量表各因子比较采用t检验;采用Person法对病例组家庭功能评定量表评分与症状自评量表评分关系进行分析.结果 病例组家庭功能评定量表(除外角色因子与情感介入因子)、症状自评量表总均分及各因子得分均高于对照组,差异有统计学意义(P<0.01);除角色因子以外,病例组家庭功能评定量表其他各因子得分与症状自评

  5. 病毒感染与免疫性血小板减少性紫癜的临床观察%Clinical observation of the relationship between immune thrombocytopenic purpura and virus infection

    Institute of Scientific and Technical Information of China (English)

    张永卓

    2013-01-01

    Objective To investigate the relationship between immune thrombocytopenic purpura (ITP) and virus infection.Methods A retrospectively analysis was based on the clinical records.ELSIA tests of EBV and CMV antibody were performed at 50 children suffered from ITP.The clinical characteristics and therapeutic effects in viral infection group and non-viral infection group were compared.Results Thirty-eight children in 50 cases who suffered from ITP were infected by EBV or CMV.Between viral infection group and non viral infection group,there was no significant difference in clinical features,hemoglobin and platelet (P > 0.05).But,it showed that the effects of viral infection group were better than those of non viral infection group at the time of two months and six months after treatment (P < 0.05).There were 18 cases ineffective in the viral infection group for six months treatment.There was the higher chronic tendency incidence in viral infection group (47.3%) than that in the non viral infection group (8.3%).Conclusions Most ITP patients infected by virus.Virus associated ITP had poor treatment effect and is easy to prolong course.%目的 探讨免疫性血小板减少性紫癜(ITP)与病毒感染的关系.方法 回顾性分析50例ITP儿童的临床资料,采用ELISA法检测50例ITP患儿血清病毒抗体(EB病毒及巨细胞病毒等),比较病毒抗体检测在病毒感染组及非病毒感染组ITP患儿中的临床特点及治疗效果.结果 病毒血清学检测:病毒感染38例,非病毒感染12例.病毒感染组与非病毒感染组比较:①两组临床表现、Hb及血小板计数比较差异均无统计学意义(P>0.05);②治疗后2个月效果比较差异有统计学意义(P<0.05),病毒感染组初始疗效较非病毒感染组治疗有效率低;③治疗后6个月两组疗效比较差异有统计学意义(P<0.05),治疗后6个月病毒感染组无效18例(47.4%),且呈慢性倾向,明显高于非病毒感染组(8.3%).结论

  6. 试论IgA肾病临床表现与肾脏病理的关系%the Relationship between IgA Nephropathy Clinical Manifestationand Renal Pathology

    Institute of Scientific and Technical Information of China (English)

    何东; 廖静

    2013-01-01

    目的临床分析IgA肾病患者的临床表现及肾脏病理关系。方法选取我院2011年8月至2012年8月收治的200例肾穿刺活检患者,给予B超肾活检、免疫检查、光镜检查,分析确诊的IgA临床特点与病理。结果经过检查后得知,有70例患者确诊为IgA肾病,其中15例肾病综合征、2例肾小球肾炎、9例血尿、17例隐匿性肾小球肾炎、25例慢性肾小球肾炎、1例肾功能不全、1例妊娠伴随慢性肾炎。病理类型:12例轻微病变、15例系膜增殖型、25例局灶节段性硬化、9例FSGS型、5例增生硬化型。结论针对IgA肾病患者,其临床表现和病理表现之间的严重程度不完全相符,实施肾活检,可有有效判断肾脏疾病病理类型,有利于确定治疗方案,改善预后。%Objective Clinical analysis of the relationship between theclinical manifestation and renal pathology in patients with IgA nephropathy. Methods In our hospital from 2011 August to 2012August were treated 200 cases of renal biopsy in patients with B-mode ultrasonography, renal biopsy, immunological examination, light microscopy, IgA analysis of clinical characteristics andpathologic diagnosis. Results After examination after that, of 70 patients diagnosed as IgA nephropathy, of which 15 cases of nephrotic syndrome, 2 cases of glomerulonephritis, 9 cases of hematuria, 17 cases of Latent Glomerulonephritis, 25 cases of chronic glomerulonephritis, 1 cases of renal insufifciency, 1 cases of pregnancy with chronic nephritis. Pathological types:12 cases ofmild lesion, 15 cases of mesangial proliferative type, 25 cases of focal segmental sclerosis, 9 cases of type FSGS, 5 cases ofproliferative sclerosing. Conclusion Patients with IgA nephropathy, the severity of the clinical manifestations andpathological findings between the not entirely consistent, implementation of renal biopsy, can effectively judge thepathological type of kidney disease, to determine the

  7. Relationship between the lnspiratory Capacity and Clinical Characters of Stable Chronic Obstructive Pulmonary Disease%慢性阻塞性肺疾病稳定期患者深吸气量临床特征性研究

    Institute of Scientific and Technical Information of China (English)

    刘波; 汪俊; 李可可; 刘晓

    2011-01-01

    目的 探讨深吸气量( inspiratory capacity,IC)与慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者临床特征的相关性.方法 2009年12月- 2010年6月纳入84例稳定期COPD患者,测定6分钟步行试验(6-minute walk test,6MWT)、圣乔治生活问卷评分(St George's respiratory questionnaire,SGRQ)及肺功能检查:第1秒用力呼气容积(forced expirotovy volume in one second,FEV1)、IC、IC与肺总量(total lung capacity,TLC)比值(IC/TLC)等相关指标,并进行相关性分析.结果 6MWT值与FEV1无明显直线相关(r=0.14,P>0.1);6MWT值与FEV1≥60%无明显直线相关(r=0.16,P>0.1);6MWT值与IC值呈正的直线相关(r=0.317,P<0.01);6MWT值与IC/TLC值呈正的直线相关(r=0.274,P<0.01);SGRQ值与FEV1呈负的直线相关(r=-0.307,P<0.01);SGRQ值与IC值无直线相关(r=-0.001,P>0.25);SGRQ值与IC/TLC值无直线相关(r=-0.003,P>0.25).结论 对COPD患者,IC比FEV1更准确地反映患者的运动耐量的程度,FEV1比IC更准确地反映患者呼吸困难的严重程度.%Objective To explore the relationship between the inspiratory capacity (IC) and clinical characters of stable chronic obstructive pulmonary disease (COPD). Methods Between December 2009 and June 2010, 84 patients with stable COPD were enrolled. Lung function (FEV1, IC, IC/TLC) ,6 minute walk-test (6MWT) and St George's respiratory questionnaire (SGRQ) were examined. The relationship among FEV1, IC, IC/TLC, and the results of 6MWT and SGRQ by Pearson correlation analysis. Results There was no linear correlation between 6MWT and FEV1 (r=0. 14,P>0. 1), and 6MWT and FEVl>60% (r=0. 16,P>0. 1). There was positive correlation between 6MWT and IC (r=0. 317,P0. 25), and SGRQ and IC/TLC (r= -0. 003,P>0. 25). Conclusion In stable COPD patients, IC may be more accurate than FEV1 in refection of exercise tolerance while FEV1 may be more sensitive than IC in evaluation of dyspnea.

  8. Analysis of relationship between age at onset and clinical features of migraine%发病年龄与偏头痛临床特点的关系分析

    Institute of Scientific and Technical Information of China (English)

    冯智英; 李颖; 邹静; 李焰生

    2011-01-01

    目的 分析发病年龄与偏头痛临床特点的关系,为临床判断偏头痛的预后提供参考.方法 收集门诊诊断为偏头痛的连续患者447例,其中先兆性偏头痛(MA组)62例,无先兆性偏头痛(MO组)385例.记录两组患者的年龄、性别、头痛发病年龄(AAO)、首次就诊年龄、病程、家族史以及头痛强度、频率和持续时间等相关资料.两组患者按AAO进行再分组(≤18岁为未成年组,>18岁为成年组),分别对AAO与家族史和头痛强度、频率、持续时间的关系进行统计学分析.结果 MA组和MO组患者中女性分别占81.3%和66.1% (P <0.05),两组患者的首次就诊年龄、病程和头痛持续时间比较,差异均有统计学意义(P<0.05).在MO患者中,未成年组与成年组的首次就诊年龄、病程、家族史及头痛频率和持续时间比较,差异均有统计学意义(P<0.05).多变量Logistic回归分析发现,就诊年龄、病程、家族史、头痛频率是独立危险因素.结论 起病早、家族史明显、头痛严重的偏头痛患者,预后较差;在中国人群中,AAO可作为反映偏头痛预后的指标之一.%Objective To investigate the relationship between age at onset (AAO) and clinical features of migraine so as to provide references for prognosis estimation of migraine. Methods Four hundred and forty-seven consecutive patients with migraine were enrolled, among whom 62 were migraine with aura ( MA group), and 385 were migraine without aura ( MO group). The related data about age, gender, AAO, age of first diagnosis, course of disease, family history, intensity of migraine, frequency of migraine and duration of migraine of patients in two groups were recorded. Patients in both groups were subdivided into immaturity group ( ^ 18 years old) and adult group( > 18 years old) respectively. The relationship between AAO and family history, intensity of migraine, frequency of migraine and duration of migraine was statistically

  9. A clinical study on the relationship between oral hygiene and chronic gastritis.%口腔卫生与慢性胃炎关系的临床研究

    Institute of Scientific and Technical Information of China (English)

    陈发明; 孙海花; 刘民; 张修平; 邓玲玲

    2001-01-01

    目的:为探讨口腔卫生与慢性胃炎的关系。方法:76例胃粘膜幽门螺杆菌(Helicobacterpylori,Hp)检测阳性慢性胃炎患者为慢性胃炎组,72例健康自愿者组成对照组,对所有受检者进行口腔卫生检查,并对其牙菌斑Hp进行检测,比较两组的差别;慢性胃炎组随机分成A、B两组后接受抗Hp治疗,A组同时进行口腔治疗与口腔教育,B组为对照,3月后观察抗Hp治疗的疗效,比较两组的差别。结果:慢性胃炎组口腔卫生状况明显较对照组差(P<0.01),且口腔卫生状况与慢性胃炎程度有关(P<0.05);牙菌斑Hp检测结果亦显示口腔卫生愈差、慢性胃炎愈严重,Hp阳性率愈高。3月后A组的疗效明显优于B组。结论:口腔卫生好坏与慢性胃炎的发病密切相关,Hp寄生于牙菌斑可能是导致慢性胃炎发病和复发的一个重要因素。%Objective:To investigate the relationship between oral hygieneand chronic gastritis.Methods:76 patients with chronic gastritis (Helicobacter pylori polymerase chain reaction detection were positive, Hp-PCR positive) and 72 controls were studied their oral hygiene and the Hp in their dental plaque.Chronic gastritis patients were received anti-Hp therapy and then divided into 2(A and B)groups.A group was treated by supergingival subgingival curettage,and received oral health education while B group was compared.Results:There were significant differences of Hp positive rate and debris index(DI),calculus index(CI),plaque index(PLI),gingival index(GI) between chronic gastritis group and control group(P<0.01),and they all related with the severity of chronic gastritis(P<0.01).Oral hygiene treatment and oral health education are benefit for anti-Hp therapy of chronic gastritis.Concusions:It is indicated that the relationship between oral hygiene and chronic gastritis is close clinically,Hp in dental plaque perhaps is one of the way to Hp infecton.

  10. The clinical effect of endoscopic sinus surgery for chronic sinusitis and its relationship with clinical classification%鼻内镜手术治疗慢性鼻窦炎的疗效及其与临床分期的关系

    Institute of Scientific and Technical Information of China (English)

    郑锋

    2015-01-01

    Objective:To observe the therapeutic effect of endoscopic sinus surgery for chronic sinusitis and its relationship with clinical classification.Methods:84 patients with chronic sinusitis were selected,they were randomly divided into the two groups on average,patients in the control group were treated with traditional operation,while patients in the observation group were treated by endoscopic surgery,The two groups were followed up for 1 year,we compared the clinical efficacy.Results:The total effective rate of the observation group was 71.43% better than that of the control group 92.86%,the difference was statistically significant(P<0.05).The total effective rate of type I and type Ⅱ were significantly higher than that of type Ⅲ,the recurrence rate of sinusitis in the observation group was significantly lower than that of the control group(P<0.05).Conclusion:Endoscopic sinus surgery for chronic sinusitis can improve the clinical efficacy of patients,reduce the recurrence rate of postoperative sinusitis.%目的:观察鼻内镜手术治疗慢性鼻窦炎的疗效及其与临床分期的关系。方法:收治慢性鼻窦炎患者84例,随机平分为两组,对照组采用传统手术治疗,观察组采用鼻内镜手术治疗,两组术后均随访1年,比较术后临床疗效。结果:观察组治疗后总有效率92.86%,优于对照组的71.43%,差异有统计学意义(P<0.05);Ⅰ型、Ⅱ型总有效率均显著高于Ⅲ型;观察组术后鼻窦炎复发率显著低于对照组(P<0.05)。结论:鼻内镜手术治疗慢性鼻窦炎可提高患者的临床疗效,降低术后鼻窦炎的复发率。

  11. MRI in temporal lobe epilepsy. Correlation between EEG, SPECT and clinical features

    Energy Technology Data Exchange (ETDEWEB)

    Uesugi, Hideji; Onuma, Teiichi; Matsuda, Hiroshi; Ishida, Shiro [National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, Tokyo (Japan)

    1996-02-01

    The relationship between MRI, SPECT, EEG and clinical features in temporal lobe epilepsy was investigated. Subjects were 162 patients (84 males, 78 females) whose average age was 38.1{+-}12.1 years. SPECT was carried out in 45 patients. The results were as follows: abnormal MR images were obtained in 36% of the group without epileptic discharge, and in 42% of the group with temporal spikes. There was no correlation between epileptic discharge in EEG and MRI abnormality. The lateralities of epileptic discharge and MRI were in disagreement in 9 of 39 patients (23%), indicating that determining the epileptic focus from scalp EEG was difficult. There was no correlation between the basic activity in EEG and abnormality in MRI. The rate of abnormal SPECT (89%) was higher than that of abnormal MRI (40%). The rate of the group with ictal automatism (52%) was higher than that of the group without ictal automatism (35%). The rate of abnormal MR images was high in the group with encephalitis (73%). The rate was higher in the group with febrile convulsion (62%) than in the group without it (28%). The rate of the abnormal MR images was higher in the group with a seizure frequency of at least several mal/month (48%) than in the group with a seizure frequency of less than several mal/year (29%). (author).

  12. RESEARCH ON RELATIONSHIP BETWEEN TREATMENT ADHERENCE AND CLINICAL MANIFESTATIONS OF HYPERTENSIVE RETINOPATHY%治疗依从性与高血压视网膜病变临床表现关系的研究

    Institute of Scientific and Technical Information of China (English)

    孙春晖

    2014-01-01

    Objective To explore the relationship between treatment adherence and clinical manifesta-tions of hypertensive retinopathy .Methods Questionnaires were distributed to community members to in-vestigate the amount of knowledge they have known on hypertension retinopathy .By means of adopting a series of positive measures ,we have strengthened the awareness of hypertensive retinopathy ,and taught people how to take medicine in a scientific and regulatory manner and how to prevent and control the dis-ease .Results For three successive years ,the prevalence of hypertensive retinopathy did not change signifi-cantly ( P >0 .05) .Different treatment adherence affected the development tendency of hypertensive reti-nopathy ( P < 0 .01 ) . Conclusion T he development pace of hypertensive retinopathy can be deferred as long as we strengthen the intervention of hypertension and focus on education as well as guidance of its treatment adherence .%目的:探讨不同的治疗依从性与高血压视网膜病变临床表现之间的关系。方法①发放问卷调查社区人员对高血压视网膜病变的知识了解度;②采用一系列积极措施,加强人们对高血压视网膜病变的认识,指导规范、科学用药及对该病的防控。结果①连续三年高血压视网膜病变罹患率变化不明显(P >0.05);②不同的治疗依从性会影响高血压视网膜病变的发展趋势(P <0.01)。结论在加强社区高血压干预的基础上,注重治疗依从性的教育和指导,可延迟高血压视网膜病变的发展速度。

  13. Orthodontic treatment in the relationship between tooth and root absorption of clinical studies%探讨正畸治疗中拔牙与牙根吸收关系

    Institute of Scientific and Technical Information of China (English)

    赵彦文

    2015-01-01

    ObjectiveTo study the analysis of the orthodontic treatment of the relationship between tooth and root absorption.methodsFrom January 2012 to January 2015, were accepted our dental orthodontic treatment of patients with a total of 200 cases included in the study, grouped according to whether a tooth out, observed two groups of patients receiving orthodontic treatment before and after root absorption differences. ResultsTooth, tooth group patients received orthodontic treatment before root absorption, by contrast, no signiifcant differences (P>0.05), no statistical signiifcance; Tooth group of patients after orthodontic treatment, root absorption is obviously higher than that of the tooth extraction group, there was a signiifcant difference compared (P<0.05), with statistical significance.ConclusionIn the orthodontic treatment can accentuate tooth root absorption, whether during orthodontic treatment need tooth extraction and identiifcation of high-risk groups is clinical research further.%目的:分析正畸治疗中拔牙与牙根吸收的关系。方法选择2012年1月~2015年1月我院口腔科收治的接受正畸治疗患者200例作为研究对象,根据是否拔牙分为拔牙组和非拔牙组,对比观察两组患者接受正畸治疗前、后牙根吸收情况方面的差异。结果拔牙组、非拔牙组患者接受正畸治疗前牙根吸收情况对比,差异无统计学意义(P>0.05);拔牙组患者接受正畸治疗后,牙根吸收情况明显高于非拔牙组,差异有统计学意义(P<0.05)。结论在正畸治疗中拔牙会加重牙根吸收,正畸治疗期间是否需要拔牙以及对高危人群的识别是临床进一步研究重点。

  14. Relationship between Mild Fetal Lateral Cerebral Ventriculomegaly and Clinical Prognosis%胎儿侧脑室轻度增宽的超声测量结果与临床预后的关系研究

    Institute of Scientific and Technical Information of China (English)

    傅文英; 孙耕妹; 赵佩英

    2011-01-01

    目的 探讨胎儿轻度侧脑室增宽与临床预后的关系.方法 选择产前检查发现侧脑室后角轻度增宽的胎儿34例为观察组,侧脑室正常的胎儿30例为对照组,进行新生儿神经行为(NBNA)评分,比较两组有无差异.结果 34例胎儿侧脑室轻度增宽中仅1例染色体为21-三体,1例未查染色体;有3例在妊娠中期首次发现侧脑室轻度增宽后因加重而引产.两组胎儿性别构成比比较,差异无统计学意义(P>0.05);观察组胎儿出生后NBNA评分较对照组高,差异有统计学意义(P<0.05).结论 侧脑室轻度增宽的胎儿,尤其是>12 mm的胎儿,出生后发生神经系统发育不良的风险较侧脑室正常胎儿增加;侧脑室轻度增宽与胎儿性别无关;因胎儿脑室扩张是一动态的过程,如不合并染色体和其他的结构异常,大部分预后良好.%Objective To investigate the relationship between mild fetal lateral cerebral ventriculomegaly and the clinical prognosis. Methods Totally 34 fetuses were found to be with mild lateral cerebral ventriculomegaly ( MLCV group ); 30 fetuses with normal lateral cerebral ventricles were enrolled as control group. Neonatal behavioral neurological assessment ( NBNA ) was performed. Results In the MLCV group, one case was with trisomy 21, one did not undergo chromosome screening, and three were aborted due to exaggerated MLCV in the 2nd trimester. The proportions of sex showed no significant difference between these two groups ( P > 0. 05 ). The NBNA grade was significantly higher in MLCV group than in control group ( P <0. 05 ). Conclusion Fetuses with MLCV ( especially when > 12 mm ) have increased risks of nervous system ahnormalities. However, since FLCV is a dynamic process , and the prognosis can be good if no unusual chromosome and other abnormal structure exist.

  15. 人格特征及认知风格与口腔门诊患者牙科焦虑症的关系%Relationship between Personality Traits and Cognitive Styles with Dental Anxiety in Dental Clinic Patients

    Institute of Scientific and Technical Information of China (English)

    王艳

    2014-01-01

    Objective To investigate the incidence of dental anxiety and the relationship between personality traits and cognitive styles with dental anxiety .Methods 150 dental clinic patients were investigated with the modified dental anxiety scale , Eysenck person-ality questionnaire and the cognitive style of the embedded figure test .Results In all 113 valid samples ,74 .3%of patients had dental anxiety.The score of dental anxiety in field -dependence group (13.041 ±1.829) was significantly higher than that in the field -inde-pendence group(9.41 ±3.165),the difference was statistically significant (t=5.159,P<0.01).Correlation analysis revealed that neuroticism of personality questionnaire was significantly correlated with dental anxiety (r=0.402),but extroversion was negatively corre-lated with dental anxiety(r=-0.302),correlations were all statistically significant (P<0.01).There was also a significantly negative correlation between cognitive style and the score of dental anxiety (r=0.485,P<0.01).The results of regression analysis showed that neuroticism and cognitive style were the significant predictors of dental anxiety .Conclusion The occurrence rate of dental anxiety in o-ral clinic patients is high ,and personality and cognitive styles are important factors which have an important effect on dental anxiety .%目的:调查口腔门诊患者牙科焦虑症的发生情况,研究人格特征及认知风格与牙科焦虑的关系。方法选用改良牙科焦虑量表、艾森克人格问卷以及认知方式镶嵌图形测验对150名口腔门诊患者进行问卷调查。结果113名有效样本中,74.3%的患者有牙科焦虑的产生。场依存组牙科焦虑得分(13.041±1.829)显著高于场依存组(9.41±3.165),差异具有统计学意义(t=5.159,P<0.01)。相关分析结果显示,人格问卷中的神经质与牙科焦虑呈显著正相关(r=0.402),内外倾与牙科焦虑呈显著负相关(r=-0

  16. Relationships of magnetic resonance imaging characters and clinic presentations of children cerebral palsy%儿童脑性瘫痪MRI特征与临床表现的相关性

    Institute of Scientific and Technical Information of China (English)

    王莹; 王海宝; 余永强; 徐丽艳; 陈玉萍

    2014-01-01

    Objective To explore the valuation of MRI in clinic diagnosis of children cerebral palsy( CP) by tes-ting relationships between types of CP, gross motor function( GMFCS) ,gestational age at birth and MRI findings of the brain. Methods The clinic and MRI data were collected and their correlations were analyzed. Results A-mong 143 cases of cerebral palsy,52 cases were periventricular white matter injury( PWMI) ,31 cases were diffusive encephalopathy,19 cases were brain malformations,11 cases were focal cerebral vascular accident,24 cases were normal and 6 cases were unclassifiable. Distributions of GMFCS were significantly different among various neuroim-aging findings(χ2 =87.974,P=0.000,Fisher exact test). For PWMI, preterm infants were mainly involved with spastic diplegia or spastic hemiplegia, and GMFCS levels wereⅠ~Ⅲ. Diffusive encephalopathy was most com-monly shown in dyskinetic CP and spastic quadriplegia,and GMFCS levels were Ⅳ~Ⅴ. Brain malformations and focal cerebral vascular accident were common in term infant patients, and for GMFCS levels the former were Ⅳ~Ⅴ,while the latter wereⅠ~II. Conclusion Correlations are significant between MRI findings with types of CP, gross motor function and gestational age at birth and it's important for MRI in earlier diagnosis and prognosis valua-tion of cerebral palsy.%目的通过分析脑性瘫痪( CP)患儿磁共振表现与其类型、粗大运动功能分级( GMFCS)及出生胎龄的关系,探讨MRI在小儿CP临床诊断中的价值。方法收集143例CP患儿的临床和MRI资料,回顾性分析其间相关性。结果MRI表现为室周白质损伤(PWMI)52例,弥漫性脑损伤31例,脑发育异常19例,局灶性脑血管意外11例,正常24例,无法分类性病变6例。不同类型MRI表现的GMFCS分布差异有统计学意义(χ2=87.974,P =0.000, Fisher 精确检验)。 PWMI的患儿中,早产儿多见,且主要为双瘫及偏瘫, GMFCSⅠ~Ⅲ级较多。弥漫性脑损伤中,四肢瘫及不

  17. Digital Relationships

    DEFF Research Database (Denmark)

    Ledborg Hansen, Richard

    -­‐Jones, 2011) for increases in effectiveness and efficiency we indiscriminately embrace digital communication and digitized information dissemination with enthusiasm – at the risk of ignoring the potentially dark side of technology. However, technology also holds a promise for better understanding precisely...... of residual deposits from technology in organizations and its effect on individuals ability to connect to one another. Based on the case study the paper describes indications and suggests potential implication hereof. Given the inherent enhancement possibilities of technology our expectation for entertainment......-­rich information and highly interesting communication are sky-­high and rising. With a continuous increase in digitized communication follows a decrease in face-­to-­face encounters and our ability to engage in inter-­personal relationships are suffering for it (Davis, 2013). The behavior described in this paper...

  18. 毛细支气管炎患儿临床严重程度与哮喘发生的相关因素分析%Relationship between clinical severity of infants with bronchiolitis and asthma and related factors

    Institute of Scientific and Technical Information of China (English)

    丁涛; 张士辉

    2015-01-01

    Objective To explore the relationship between clinical severity of capillary bronchitis in children and asthma and high risk factors for the development of asthma.Methods A retrospective analysis was conducted on the clinical data of 120 cases of capillary bronchitis in children admitted in Qihe County People ’ s Hospital from July 2012 to July 2104 to analyze the relationship between the incidence of asthma and the types of capillary bronchitis.Logistic analysis was carried out to analyze the high risk factors of asthma in children with capillary bronchitis.Results The incidence of asthma in children was 28.33%.It was 25.00% in children with mild capillary bronchitis and 39.29%in those with severe bronchitis, and the difference was significant (χ2 =4.03,P<0.05).Severe capillary bronchitis, parental smoking, allergic original positive, allergic rhinitis and family history of asthma were significantly correlated with asthma (χ2 value was 0.579, 8.774, 9.146, 5.704 and 36.729, respectively,OR value was 3.821, 5.830, 6.531, 4.321 and 26.592, respectively,95%CI was 1.157-12.498, 1.775-18.221, 1.720-18.231, 1.281-109.251 and 8.014-111.251, respectively, all P<0.05).Conclusion Passive smoking, family history of asthma and allergic constitution may be high risk factors for severe capillary bronchitis developing asthma, so they should be paid much attention to reduce the incidence of asthma fundamentally.%目的:分析毛细支气管炎患儿临床严重程度与哮喘发生的关系及其高危因素。方法回顾性分析齐河县人民医院自2012年7月至2104年7月收治的120例毛细支气管炎患儿的临床资料,分析其哮喘的发生率与毛细支气管炎疾病类型的关系,同时应用Logistic法分析毛细支气管炎患儿发生哮喘的高危因素。结果该组患儿哮喘发生率为28.33%,其中轻型毛细支气管炎患儿哮喘发生率为25.00%,重型毛细支气管炎患儿哮喘发生率为39.29%,两者哮喘

  19. The relationship between the MRI findings and clinical features in 22 full-term infants with neonatal hypoglycemia%足月新生儿低血糖22例磁共振表现与临床特征

    Institute of Scientific and Technical Information of China (English)

    顾秋芳; 胡黎园; 陈超; 曹云; 邵肖梅; 程国强; 王来栓; 朱珍; 周文浩

    2013-01-01

    Objective To evaluate the relationship between the MRI findings and clinical characteristics in full-term infants with neonatal hypoglycemia. Methods The clinical records of 22 neonates with isolated hypoglycemia who were referred to Children' Hospital of Fudan University from June 1, 2008 to June 30, 2011 were reviewed retrospectively. The patients were divided into two groups according to the early magnetic resonance imaging ( MRI ) findings: MRI - group ( n = 9 ) were patients who showed normal brain imaging while MRI + group ( n = 13 ) were patients who showed abnormal brain imaging finding. The clinical characteristics of neonatal hypoglycemia were compared between two groups. The brain injury patterns identified from early MRI scans were presented. Results The frequencies of risk factors for hypoglycemia were similar in two groups ( P = 0.054 ). The duration when hypoglycemia was first detected was 1( 0. 5 - 17 ) h in MRI - group and 46. 6( 12. 7 - 78. 3 ) h in MRI + group, respectively, P = 0. 000. MRI - group established stable blood glucose levels faster than the MRI + group, ( 54. 1 ± 18. 2 ) h vs ( 71. 6 ± 15. 1 ) h, P = 0. 023. The occurrences of symptoms were more frequent in MRI + group than MRI - group ( P = 0. 000 ). Among MRI + group, 10 had predominant bilateral parieto-occipital cortex and subcortical white matter abnormalities, 1 had unilateral occipital and parietal area lesions, 2 had punctate white matter lesions in periventricular region or centrum semiovale. Conclusions Screening and management of babies at risk for neonatal hypoglycemia are recommended. Infants who were identified less than 12 hours of postnatal age remained asymptomatic, and there were no changes in the MRI imaging. The duration from birth till establishment of the stable blood glucose levels might be suggestive of association with neuroimaging changes and long-term neurological changes. The most common area of hypoglycemia-associated brain injury was in the parietal

  20. Why clinical trials of vitamin E and cardiovascular diseases may be fatally flawed. Commentary on "The Relationship Between Dose of Vitamin E and Suppression of Oxidative Stress in Humans"

    Science.gov (United States)

    Many investigators have pondered the apparent paradox in the conflicting evidence about the cardiovascular benefits of vitamin E suggested by experimental and observational studies versus that reported from randomized clinical trials. In the light of recent evidence, particularly a new clinical tria...

  1. Relationship between

    Institute of Scientific and Technical Information of China (English)

    TIAN; Lide

    2001-01-01

    [1]Craig, H., Isotopic variations in meteoric waters, Science, 1961,133: 17020703.[2]Dansgaard, W., Stable isotope in precipitation, Tellus, 1964, 14(4): 436-468.[3]Merlivat, L., Jouzel, J., Global climate interpretation of the deuterium-oxygen 18 relationship for precipitation, J. Geophys.Res.. 1979, 84: 5029-5033.[4]Jouzel, J., Merlivat, L., Deuterium and oxygen-18 in precipitation: modeling of the isotope effects during snow formation.J. Geophys. Res., 1984, 89(D7): 11749-11757.[5]Sonntag, C., Klitzsch, E., Lohnert, E. P. et al., Palaeoclimatic information from deuterium and oxygen-18 in Carbon- 14-dated North Saharan groundwaters, in Isotope Hydrology, IAEA,Vienna, 1979, 569-581.[6]Armengaud, A., Koster, R. D., Jouzel, J. et al., Deuterium excess in Greenland snow: analysis with simple and complex models, J. Geophys. Res., 1998, 103(D8): 8947-8953.[7]Jouzel, J., Merlivat, L., Lorius, C., Deuterium excess in an East Antarctic ice core suggests higher relative humidity at the oceanic surface during the last glacial maximum, Nature, 1982, 299 (5885): 688-691.[8]Qin Dahe, Ren Jiawen, Wang Wenti, et al., Distribution of δD in 25 cm surface snow across the Antarctic, Science in China, Ser. B, 1992,22(7): 768-776.[9]Yao Tandong, Ding Liangfu, Pu Jianchen et al., Characteristic of δ 18O in snow and its relation with moisture sources in Tanggula Mountains, Tibetan Plateau, Chinese Science Bulletin (in Chinese), 1991, (20): 1570-1573.[10]Zhang Xinping, Shi Yafeng, Yao Tandong, Variational features of precipitation, δ 18O in Northeast Qinghai-Tibet Plateau.Science in China, Ser. D, 1995, 38(7): 854-864.[11]Zhang Xinping, Yao Tandong, Relations between weather systems affecting Tibetan Plateau and oxygen isotope in precipitation, Journal of Glaciology and Geocryology (in Chinese), 1995, 17(2): 125-131.[12]Tian Lide, Yao Tandong, Yang Zhihong, δ18O in precipitation and moisture sources upon the Tibetan Plateau, Cryosphere

  2. Relationship between professional self-concept and social-support among nursing students during clinical practice%护生专业自我概念与社会支持相关性研究

    Institute of Scientific and Technical Information of China (English)

    吕芳菲; 李春芳

    2011-01-01

    Objective: To explore the relationship between professional self-concept and social-support status among nursing students during clinical practice, then provide theoretical reference for training their positive professional self-concept. Methods: A survey was conducted among 185 nursing students by Professional Self-concept of Nurses Instrument and Social Support Rating Scale. Results: The total score of professional self-concept was 2.83±0.46. While the dimension of flexibility ranked the first (2.94±0.53), and the last one was satisfaction dimension (2.73±0.51). The total score of social-support was 39.35±5.37. It was higher than that in Chinese normal population (f=11.66, ,P<0.01).Social-support level was positive related with professional self-concept (P<0.05, P<0.0\\). The result of stepwise multiple variable regression analysis showed that objective support and the utilizing of support were significant predictors of professional self-concept. Conclusions: Social-support level may influence nursing students' professional self-concept. Hospital and school managers should pay some attentions on social-support system building. It would be beneficial to train nursing students' active professional self-concept.%目的:调查护生专业自我概念与社会支持状况,并了解二者的相关性,为培养护生积极的专业自我概念提供依据.方法:采用护理专业自我概念量表、社会支持评定量表,对185名护生进行调查.结果:护生专业自我概念总分为(2.83±0.46)分,其中灵活性得分最高,为(2.94±0.53)分,满意度得分最低,为(2.73±0.51)分.护生的社会支持总分为(39.35±5.37)分,与国内常模得分比较差异有统计学意义(t=11.66,P<0.01).护生专业自我概念与社会支持评分呈正相关(P<0.01).多元回归分析显示,客观支持和支持利用度是护生专业自我概念的主要影响因素.结论:护生社会支持水平对其专业自我概念有影响,医院和学校应建立

  3. A study on the relationship with 61 rare cases of abnormal chromosome karyotype and clinical diseases%61例国内外首报的染色体异常核型与临床关系研究

    Institute of Scientific and Technical Information of China (English)

    涂向东; 张宝珍; 曾健; 丛学文; 王志红; 周游

    2011-01-01

    目的 了解国内外首报的染色体异常与生育缺陷和小儿智力低下的关系.方法 抽取6784例患有生育缺陷和小儿智力低下患者外周血,进行常规染色体分析,部份患者孕中期抽取羊水、脐带血进行染色体核型分析.结果 发现染色体异常核型714例,其中61例为国内外首次发现的染色体异常核型.通过对61例特殊患者进行临床病例分析,发现29例患者有习惯性流产史,占总数48%,10例患者为无精子或严重少精子症,占总数16%,5例患者为不育症,占总数0.8%,5例患者精子畸形率>30%,占总数0.8%,3例表现为原发性闭经,占总数0.5%,2例生育畸形儿,占总数0.3%,2例智力低下,占总数0.3%,3例胎儿发育畸形,占总数0.5%,2例平衡易位携带者,占总数0.3%.结论 染色体异常是导致生育缺陷和小儿智力低下的遗传因素之一.%Objective: To study the relationship of chromosome aberration to birth defects and infantile mental retardation. Methods: Peripheral blood from 6784 patients with infertility, habitual abortion, dead fetus or abnormal birth and amniotic fluid of the middle stage of pregnancy or cord blood from part of those patients was sampled. Chromosome analysis was performed on cultured lymphocytes. Results: There were 714 cases of abnormal chromosome karyotype including 61 rare cases reported firstly in the world. Further clinical analysis showed 29 cases of spontaneous abortion (48%), 10 cases of oligospermia or azoospermia ( 16% ), 5 cases of infertility (0.8% ), 5 cases of teratospermia (0.8% ) , 3 cases of primary amenorrhea (0.5% ) , 2 cases of congenital malformation (0.3% ), 2 cases of mental retardation (0.3% ), 3 cases of fetal development malformation (0.5% ) and 2 carrier of chromosomal balanced translocation (0.3% ). Conclusion: Chromosomal abnormality is one of the genetic factors leading to birth defects and infantile mental retardation.

  4. Twist在子宫内膜腺癌的表达及其与临床生物学行为的关系%Expression of Twist in endometrial adenocarcinoma and its relationship with clinical biological behaviors

    Institute of Scientific and Technical Information of China (English)

    杨丞; 饶翔

    2013-01-01

    Objective To investigate the expression and significance of Twist protein in atypical hyperplasia and endometrial adenocarcinoma. Methods Thirteen samples of normal endometrium, 25 of atypical hyperplasia, 54 of endometrial adenocarcinoma were collected. The expression of Twist protein was detected by immunohistochemis try, and its relationship with clinical biological behaviors of endometrial adenocarcinoma was analyzed. Results The expression rates of Twist protein in normal endometrium, atypical hyperplasia, endometrial adenocarcinoma were 15.4% (2/13), 48.0% (12/25), 74.1% (40/54), respectively. The differences between the three groups were statistically significant (P0.05). Conclusion Over-expression of Twist protein in endometrial atypical hyperplasia and endometrial adenocarcinoma is correlated with development of carcinoma. The protein could be used as one of the valuable reference index for the diagnosis, differential diagnosis and prognosis of endometrial adenocarcinoma.%目的 研究Twist蛋白在非典型增生子宫内膜和子宫内膜腺癌中的表达及其意义.方法 选取13例正常内膜组织、25例非典型增生内膜、54例子宫内膜腺癌,运用免疫组织化学方法检测Twist蛋白在各组织中表达情况,并分析其与子宫内膜腺癌的临床生物学行为的相关性.结果 正常子宫内膜、非典型增生内膜和子宫内膜腺癌中Twist蛋白阳性表达率分别为15.4% (2/13)、48.0% (12/25)、和74.1% (40/54),三组之间的阳性率差异均有显著统计学意义(P<0.01);在子宫内膜腺癌组中,Twist蛋白在Ⅲ级肿瘤中的阳性率明显高于Ⅰ、Ⅱ级肿瘤,肌层浸润深者阳性率高于肌层浸润浅者,ⅢA期阳性率高于Ⅰ~Ⅱ期,其差异均有统计学意义(P<0.05);而不同年龄的患者间比较,Twist蛋白阳性率差异无统计学意义(P>0.05).结论 Twist蛋白的过表达与子宫内膜非典型增生和腺癌的发生发展有关,可作为子宫内膜

  5. Relationship Between Histopathology and Clinical Prognosis of Invasive Pituitary Adenoma%侵袭性垂体腺瘤的组织学与临床预后的关系

    Institute of Scientific and Technical Information of China (English)

    李勇; 舒凯; 董芳永; 万锋; 雷霆; 李龄

    2005-01-01

    目的 分析经蝶窦入路切除的侵袭性垂体腺瘤的组织学侵袭性与临床预后的关系.方法 我科自2000年1月~2003年5月行经蝶手术切除的具有完整影像学、病理学和随访资料的侵袭性垂体腺瘤82例,其中PRL腺瘤39例,GH腺瘤13例,ACTH腺瘤6例,无功能腺瘤24例,随访时间5~30个月.结果 侵袭性垂体腺瘤MRI影像学特点为鞍底受侵下陷,部分肿瘤突入蝶窦;颈内动脉包绕;海绵窦受累,鞍隔突破等,病理检查以鞍底硬膜浸润的发生率最高,并有20例(24.4%)发现有肿瘤内卒中或出血.PRL腺瘤的全切率明显低于无功能腺瘤(P<0.01),而无功能腺瘤、GH腺瘤与ACTH腺瘤之间相差不明显.PRL腺瘤的复发率较无功能腺瘤和GH腺瘤高(P<0.05).结论 侵袭性垂体腺瘤中,无功能腺瘤与GH腺瘤的治疗效果优于PRL腺瘤,垂体腺瘤的侵袭性生物学行为导致手术全切机率下降,是术后复发的主要原因.%To study the relationship between histopathology and clinical prognosis of invasive pituitary adenoma subjected to transsphenoidal surgery. Methods: The enrolled were 82 patients with invasive pituitary adenomas undergoing transsphenoidal surgery during Jan. 2000 May 2003 in our department with full MR imaging findings, pathology data and follow-up information. The follow-up duration was 5 30 months. Results: MR imaging findings of invasive pituitary adenoma included: depression of the sellar floor, involvement of sphenoid sinus and cavernous sinus, breakthrough of diaphragma sellae,encasement of internal carotid artery, etc. Pathological examination revealed that the invasion rate of dura in sella turcica was the highest among the structures around tumor. Pituitary adenoma apoplexy was found in 20 cases (24.4%). The total removal rate for PRL-secreting adenomas was significantly lower than that for non-secreting adenomas (P<0.01), but non-, GH-, ACTH-secreting adenomas had no significant differences. The

  6. The relationship between radiographic measurement and short-term clinical outcome of distal radius fractures%桡骨远端骨折影像学测量指标与近期疗效的关系

    Institute of Scientific and Technical Information of China (English)

    汤骏; 高伟阳; 徐华梓

    2008-01-01

    目的 通过对桡骨远端骨折患者的影像学测量,分析各影像学参数和近期疗效之间的关系.方法 对62例桡骨远端骨折闭合复位石膏外固定的患者,利用StarPACS影像系统进行测量,并记录所有患者X线片的桡骨高、掌倾角及尺偏角的情况,并分析影像学测量指标与自测腕关节功能之间的关系.结果 62例桡骨远端骨折中,有50例(占80.6%)经保守治疗后效果优良.当桡骨高大于6.0 mm,掌倾角大于5°,尺偏角大于18°时,自测腕关节功能优良率较高.影像学指标和自测腕关节功能的相关性桡骨高>掌倾角>尺偏角.结论 桡骨高、掌倾角及尺偏角等可以作为桡骨远端骨折治疗效果评估的影像学指标,手法复位后影像学不达标者应当重新复位或采用手术治疗,桡骨远端骨折时应当首先考虑桡骨高的恢复.%Objective To evaluate the relationship between radiographic measurement and short-term clinical omcome of distal radius fractures. Methotis Sixty-two cases of distal radius fractures treated with closed reduction and cast immobilization were involved in the study.The X-ray films were measured in the StarPACS system to acquire radial shortening,palmar tilt and radial inclination.The relationshiD between radiographic measurements and short-term wrist joint function was analyzed. Results Fifty out of 62 (80.6%)cases achieved good results.Better wrist joint function was observed when radial shortening was greater than 6.0 mm,palmar tilt greater than 5°and radial inclination greater than 18°.The correlation between radiographic measurement and wrist function Was tightest for radius shortening,followed by palmar tilt and radial inclination. Conclusion Radial shortening,palmar tilt and radial inclination can be used as radiographic criteria for evluating results in the treatment of distal radius fractures.If these criteria are not met after manual reduction,re-manipulation or surreal intervention should

  7. The new clinical leader.

    Science.gov (United States)

    Oates, Kim

    2012-06-01

    The complexity and cost of health care, along with a greater need for accountability calls for a new style of clinical leadership. The new clinical leader will lead reform by putting the needs of the patient first and foremost, looking at current and planned services from the patient's point of view as well as the clinician's. Excellent clinical skills will remain essential but will be supplemented by a focus on team work and mentoring, patient safety, clear communication and reduction in waste and inefficiency, leading to better financial outcomes. The new clinical leaders will understand the importance of consulting widely and engaging colleagues in creating change to improve patient care. They will develop trusting and mutually respectful relationships with health service management and be able to negotiate the delicate balance between clinical judgement, resource constraints and personal loyalties by keeping the best outcome for the patient at the forefront of their thinking.

  8. 代谢综合征与轻度认知功能障碍的临床研究%Clinical Study on Relationship between Metabolic Syndrome and Mild Cognitive Impairment

    Institute of Scientific and Technical Information of China (English)

    赵晓红; 杨玉梅; 鲍娟; 王曦; 张媛媛; 赵青

    2012-01-01

    目的 探讨代谢综合征(MS)与轻度认知功能障碍(MCI)的关系.方法 124例MS患者(研究组)和71例健康体检者(对照组),据petersen等MCI诊断/排除标准纳入MCI组和认知功能正常组(NC组);MS患者代谢指标每项异常各计1分,按分值0~1、2、3、4、5分为5个亚组.比较MS与NC组间及MS各分亚组间MCI发生率及各代谢指标与认知功能评分间的关系,并对影响MCI相关因子行多因素分析.结果 (1)MCI发生率:MS组高于非MS组(P<0.01),MS组代谢紊乱积分越高发生率越高(P<0.01); (2)MCI组各代谢紊乱指标(舒张压,高密度脂蛋白HDL-C除外)均高于NC组(P<0.05),ISI低于NC组(P<0.05); (3)认知功能总评分及各分量表评分MS组低于非MS组(P<0.05); (4)各认知评分(图像自由回忆除外)与MS负相关,与空腹胰岛素(FIN)负相关(指向记忆、人像特点回忆除外),MoCA、MMSE与血压负相关.排除糖尿病患者后,以上关系不变,而认知评分与FIN由负相关变为不相关; (5)教育程度、胰岛素抵抗和MS最终进入Logistic方程(回归系数分别为-0.460/0.855/1.289).结论 (1)MS影响认知功能各个环节,MS整体对认知功能的影响大于各组份; (2)受教育程度高是MCI的保护凶素,MS、胰岛素抵抗是MCI的独立危险因素.%Objective To investigate the relationship between metabolic syndrome (MS) and mild cognitive Impairment (MCI) . Methods 124 clinical MS subjects for research group, and 71 non- MS for control, who matched in age, sex and education. According to MCI diagnostic standards of Petersen, all cases were selected into the MCI group and cognitive function normal group (NC group) . With each metabolic abnormalities, MS subjects were scored 1 point and divided into five groups according to scores 0 ~1, 2, 3, 4, 5. Results (1) MCI incidence in MS was higher than in non-MS (P<0.01). The higher metabolic score in MS, the higher MCI incidence (P<0.01) . (2) Indicators of metabolic abnormalities in MCI

  9. Relationship Among Early Secondary Clinic Intervention Treatment and Recent Prognosis of Transient Ischemic Attack%早期临床二级干预治疗与短暂性脑缺血发作预后的关系

    Institute of Scientific and Technical Information of China (English)

    周智; 蒲国兴; 尚迟; 李君; 孙维权

    2015-01-01

    Objectives: To explore the relationship among early secondary clinic intervention treatment, such as defibrination therapy, antiplatelet therapy, anticoagulation therapy, and recent prognosis of Transient Ischemic Attack (TIA) to complete stroke and to provide scientific basis for prevention,therapy and obstructing disease progress of TIA.Methods:All of the TIA objects(224) came from neurology departments of three hospitals in Xiang City from September 2013 to November 2014, which have been observed for 15 days in hospital. 75 patients with complete stroke were taken as the deteriorated group, 149 patients with incomplete stroke as the non-deteriorated group. All patients were investigated by face to face interview according to the same questionnaire, which included demographic parameters, disease history, life style, attack situation of TIA, therapy measures (defibrination therapy, antiplatelet therapy, anticoagulation therapy), and so on. The database was set up by Excel and was analyzed using the statistical software SPSS 13.0 version. Chi-square test was used to analyze the correlation between factors and TIA prognosis.Results: Of all the 224 cases, 17 cases cured with defibrination therapy deteriorated to complete stroke, and 58 cases cured without defibrination therapy deteriorated to complete stroke. There were correlation between defibrination therapy and TIA recent prognosis (χ2=4.911,P=0.027, OR=0.611, 95%CI:0.410~0.910). Defibrination therapy reduced the risk of recent progression to complete stroke for TIA patients. There was no correlation between antiplatelet therapy, anticoagulation therapy and recent prognosis of TIA.Conclusions:Defibrination therapy may be used as early secondary clinic intervention treatment measure preventing TIA from complete stroke.%目的:探寻早期临床二级干预治疗(降纤治疗、抗血小板治疗和抗凝治疗)与短暂性脑缺血发作(TIA)患者近期预后的关系,为TIA的预防、治疗及

  10. 重度腰椎滑脱患者脊柱-骨盆参数改变与症状的关系%Relationship between variations of severe isthmic spondylolisthesis spinopelvic parameters and clinical symptoms

    Institute of Scientific and Technical Information of China (English)

    吕国华; 王正光; 王冰; 尹邦良; 马泽民; 刘伟东; 李磊; 邝磊; 杨帆

    2013-01-01

    Objective To explore the relationship between variations of severe isthmic spondylolisthesis spinopelvic parameters and clinical symptoms.Methods A retrospective study of spinopelvic parameters was conducted for 45 patients with L5 severe isthmic spondylolisthesis.Their spinopelvic parameters were analyzed on preoperative full spinal radiography:grade of spondylolisthesis,pelvic incidence (PI),sacral slope (SS),pelvic tilt (PT),lumbar lordosis (LL),thoracic kyphosis (TK),SFHD,SFVD,SC7D and T9 tilting angle.According to the Oswestry score,the patients with low back pain were divided into light and severe groups.T-tests were used to compare their parameters.The analyses of multiple factor correlation,linear regression and stepwise regression were used to examine the associations between all parameters and Oswestry score.Results Grade of spondylolisthesis,PT,LL,T9 tilting angle,SFHD,SC7D,PT/SS,SFHD/SFVD,LL/TK were significantly greater and SS,SFVD were significantly smaller for patients with severe low back pain versus light low back pain (P < 0.05).PI or TK had no statistically significant difference between two groups.Multiple factor correlation,linear regression and stepwise regression:Grade of spondylolisthesis,PT,SC7D,LL and SFHD had significant positive correlations with Oswestry score.Degree of positive correlation:Grade of spondylolisthesis > SC7D > PT > LL > SFHD.And PI,TK or T9 tilting angle had no significant correlation with Oswestry score.SS and SFVD had significant negative correlations with Oswestry score.Degree of negative correlation:SS > SFVD.PT/SS,SFHD/SFVD and LL/TK had significant positive correlation with Oswestry score.Degree of positive correlation:PT/SS > SFHD/SFVD > LL/TK.Conclusion Clinical symptoms of severe isthmic spondylolisthesis have significant positive correlations with grade of spondylolisthesis,PT,SC7D,LL,SFHD,PT/SS,SFHD/SFVD,LL/TK and significant negative correlations with SS and SFVD.Low back pain symptom has no

  11. The therapeutic relationship after psychiatric admission.

    LENUS (Irish Health Repository)

    Roche, Eric

    2014-03-01

    The therapeutic relationship is one of the most central and important factors in the treatment of mental health disorders. A better therapeutic relationship is associated with service engagement, medication adherence, and satisfaction with services. This study aimed to compare the demographic and clinical factors associated with the therapeutic relationship in voluntarily and involuntarily admitted psychiatric service users. We found that individuals who had been admitted involuntarily, who had a diagnosis of a psychotic disorder, and who reported higher levels of perceived pressures on admission were more likely to have a poorer therapeutic relationship with their consultant psychiatrist. Greater levels of insight and treatment satisfaction, together with higher levels of procedural justice experienced on admission, were associated with a better therapeutic relationship. We found that the level of perceived coercion on admission was not related to the therapeutic relationship. Targeted interventions to improve the therapeutic relationship, particularly for involuntarily admitted service users, are discussed.

  12. The Clinical Method and the Clinical Dilemmas.

    Directory of Open Access Journals (Sweden)

    Luis Alberto Corona Martinez

    2011-10-01

    Full Text Available The term ‘’clinic’’, among other meanings, refers to any information that suggests the presence of an illness and is obtained through questioning and physical examination processes that take place in the course of doctor-patient relationship. The purpose of this article is to summarize the challenges and dilemmas to be considered by students and young doctors in the patient's clinical approach, which completes the vision of the unquestionable positive role of clinical medical diagnosis. Different factors that can diminish the quality of obtained clinical information, thus interfering with the diagnostic process, have been classified into four groups: dependent on disease process, dependent on the individual patient or the source of information, dependent on the setting where information was obtained and dependent on the physician. As a generalization we state that the existence of the so-called challenges or dilemmas in clinical approach imply limitations to the clinical information obtained to be used with total reliability. Nevertheless, these dilemmas do not detract, nor even slightly, the values of clinical approach in the diagnostic process.

  13. Clinical Research and Clinical Trials

    Science.gov (United States)

    ... NICHD Publications Data Sharing and Other Resources Research Clinical Trials & Clinical Research Skip sharing on social media links ... health care providers, and researchers. Find NICHD-Supported Clinical Trials Use this link to find a list of ...

  14. Clinical Competence/Clinical Credibility.

    Science.gov (United States)

    Goorapah, David

    1997-01-01

    In interviews with 10 nurse teachers and 10 clinicians, respondents could describe clinical competence more fluently than clinical credibility. Responses raised the question of whether nursing teachers must be clinically competent/credible to teach nursing. (SK)

  15. How will e-health affect patient participation in the clinic? A review of e-health studies and the current evidence for changes in the relationship between medical professionals and patients

    NARCIS (Netherlands)

    Dedding, C.; van Doorn, R.; Winkler, L.; Reis, R.

    2011-01-01

    In this report we discuss the consequences of e-health for patient-clinician encounters. On the basis of an analysis of the literature, we propose an analytical framework, composed of five different themes, regarding the impact of e-health on the relationship between patients and their health profes

  16. The Prospective Oral Mucositis Audit: relationship of severe oral mucositis with clinical and medical resource use outcomes in patients receiving high-dose melphalan or BEAM-conditioning chemotherapy and autologous SCT.

    NARCIS (Netherlands)

    McCann, S.; Schwenkglenks, M.; Bacon, P.; Einsele, H.; D'Addio, A.; Maertens, J.; Niederwieser, D.; Rabitsch, W.; Roosaar, A.; Ruutu, T.; Schouten, H.; Stone, R.; Vorkurka, S.; Quinn, B.; Blijlevens, N.M.A.

    2009-01-01

    The Prospective Oral Mucositis Audit was an observational study in 197 patients with multiple myeloma (MM) or non-Hodgkin's lymphoma (NHL) undergoing, respectively, high-dose melphalan or BEAM chemotherapy and autologous SCT at 25 European centres. We evaluated the relationship between severe oral m

  17. Boundary issues in teacher-student relationships.

    Science.gov (United States)

    Plaut, S M

    1993-01-01

    Increasing concern about therapist-patient sex has led to a consideration of boundaries in all trust-based relationships, which always include elements of power and dependency. Such relationships include those between teacher and student, especially those involving research or clinical supervision. Teacher-student relationships differ from those between therapist and patient because of the collegiality considered important for the student's development. Yet, both share the objective of fostering independence of the "client." Therefore, teachers need to find a balance of nurturance and separateness in their relationships with their students, so that the students can carry that modeling into their own careers.

  18. 儿童间歇性外斜视分型与AC/A关系的研究%Clinical investigation on relationship between types of intermittent exotropia in children and AC/A ratio

    Institute of Scientific and Technical Information of China (English)

    王岩琳; 王琪; 栾亚楠; 王利华

    2015-01-01

    Objective To investigate the relationship between accommodative convergence/accomodation ratio (AC/A) and four types of intermittent exotropia including true divergence-excess type,simulated divergence-excess type,basic type and convergence insufficiency type.Methods Prospective clinical series study.Eighty cases of children with intermittent exotropia who met the inclusion criteria were recruited in this study.The exodeviations with cycloplegic refraction correction were measured by the alternate prism cover test at both distance (6m) and near (33cm) with fixation on accommodative targets before and after 1-hour diagnostic occlusion test.The lens gradient method at distance was employed to assess the AC/A ratios of all patients.After 1-hour diagnostic occlusion test,all patients were divided into four groups according to the classification system proposed by Burian:the basic type,the true divergence-excess type,the simulated divergence-excess type and convergence insufficiency type.The average of AC/A ratios in these four groups were calculatd separately.Kruskal-Wallis test and Nemenyi test were applied to compare the differences of AC/A ratios among the four groups and between each both groups,respectively.A P value of 0.05 was considered to be significant statistically.Results Of all the 80 cases,8 were divergence-excess type,12 of the simulated divergence-excess type,36 of basic type and 24 of convergence insufficiency type.The average AC/A ratios of four groups were 4.37±5.58,2.03±1.02,1.91±2.07,0.71±0.74△/D,respectively.There were significant differences between 4 groups (P =0.006).The difference was significant in group of convergence insufficiency type compared with the other three groups (P <0.01).There was no significant difference between the other groups (P >0.05).Conclusions Measured by lens gradient method at distance,the AC/A ratios are small in general and great in individual difference.There are some differences in AC/A ratios among these

  19. Clinical Trials

    Science.gov (United States)

    Clinical trials are research studies that test how well new medical approaches work in people. Each study answers ... prevent, screen for, diagnose, or treat a disease. Clinical trials may also compare a new treatment to a ...

  20. 临床教学中医患关系现状分析及改进建议%Analysis and Improvement of Suggestions on the Relationship Between Doctors and Patients in Clinical Teaching

    Institute of Scientific and Technical Information of China (English)

    何弘水

    2016-01-01

    医患关系是一种对立统一的互动关系,近年来日趋紧张且成为社会不和谐的因素,本文分析了当前医患关系的现状,主要体现在看病难、看病贵,医护人员漠视患者权利,医疗活动商业化,社会舆论偏激报道。同时,本文对医患关系的改进提出了几点改进建议,包括以人为本,尊重患者,提高医务人员职业道德,在医学教育活动中加强对医患沟通的讨论,使学生将来能顺利执业。%The relationship between doctors and patients is a kind of unity of opposites, which has become intense increasingly and become social disharmonious factors in recent years. This paper analyzes the current status of the doctor-patient relationship, which mainly manifest as the difficulty and high cost for treatment, health care workers disregard patient rights, the medical activities of commercial, the opinion of public extremely reports. At the same time, this paper puts forward some suggestions to improve the doctor-patient relationship, including the people-oriented, respecting patients and improving professional ethics of medical personnel. Strengthening the discussion of communication between doctors and patients in medical education, so that students can practice smoothly in the future.

  1. Relationship between quality of life and clinical status in patients with gastrointestinal cancer Relación entre calidad de vida y estadio clínico en pacientes con cáncer gastrointestinal

    OpenAIRE

    Ricardo Sánchez; Fabio Alexander-Sierra; Ricardo Oliveros

    2012-01-01

    Background: previous studies with patients having cancer have shown that quality of life scores depend on the clinical stage of the disease (the more advanced the disease, the worst quality of life). Methods: in a prospective study we studied 317 patients with gastric or colorectal cancer attending the Instituto Nacional de Cancerología between 2010 and 2011; the patients completed the EORTC QLQ-C30 before receiving treatment. This instrument measures quality of life in 15 domains. Scores of ...

  2. 病案信息管理和临床路径相互作用的研究%Study of the Relationship of Medical Record Information Management and Research of Interaction of Clinical Pathway

    Institute of Scientific and Technical Information of China (English)

    丁玉梅; 张素丽

    2015-01-01

    病案信息管理是医院临床管理的重要内容,且随着科技水平的提高,电子病案系统的不断完善,病案信息管理水平得到极大提升。临床路径是当前医疗卫生事业新出现的医护工作模式。有研究指出,该模式会受到病案信息管理的作用,而反过来,临床路径也会对病案信息管理产生影响。对此,为了解病案信息管理与临床路径的具体相互作用,本文展开详细探讨研究。%The medical record information management is an important content of hospital clinical management,and with the improvement of science and technology level,the continuous improvement of the electronic medical record and system,medical record information management level is improved greatly.The clinical pathway is the current medical and health cause the emergence of new medical work patterns.Studies have pointed out that the model will be the role of the medical record information management,and in turn,the clinical pathway will also impact on medical record information management.To this,to understand the medical record information management and clinical pathway of specific interaction,this paper discusses the research.

  3. A Relationship Strategy Perspective on Relationship Portfolios

    DEFF Research Database (Denmark)

    Ritter, Thomas; Andersen, Henrik

    2014-01-01

    The paper develops a three-dimensional portfolio model for business relationships which distinguishes among six different categories. Based on assessments of customer profitability, customer commitment, and growth potential, the positioning of a given customer relationship in the portfolio allows...... managers to determine appropriate customer relationship strategies and appropriate performance indicators. Results from applying the portfolio model are reported and managerial implications and future research are discussed....

  4. Modelling of the concentration--effect relationship of THC on central nervous system parameters and heart rate -- insight into its mechanisms of action and a tool for clinical research and development of cannabinoids.

    Science.gov (United States)

    Strougo, A; Zuurman, L; Roy, C; Pinquier, J L; van Gerven, J M A; Cohen, A F; Schoemaker, R C

    2008-09-01

    Pharmacokinetics after pulmonary administration of delta-9-tetrahydrocannabinol (THC) and its major metabolites 11-OH-THC and 11-nor-9-COOH-THC was quantified. Additionally, the relationship between THC and its effects on heart rate, body sway and several visual analogue scales was investigated using pharmacokinetic-pharmacodynamic (PK-PD) modelling. This provided insights useful for the research and development of novel cannabinoids and the physiology and pharmacology of cannabinoid systems. First, the PK-PD model gave information reflecting various aspects of cannabinoid systems. The delay between THC concentration and effect was quantified in equilibration half-lives of 7.68 min for heart rate and from 39.2 to 84.8 min for the CNS responses. This suggests that the effect of THC on the different responses could be due to different sites of action or different physiological mechanisms. Differences in the shape of the concentration-effect relationship could indicate various underlying mechanisms. Second, the PK-PD model can be used for prediction of THC concentration and effect profiles. It is illustrated how this can be used to optimise studies with entirely different trial designs. Third, many new cannabinoid agonists and antagonists are in development. PK-PD models for THC can be used as a reference for new agonists or as tools to quantitate the pharmacological properties of cannabinoid antagonists.

  5. 跖腱膜炎与功能性腓肠肌挛缩关系的临床观察%Clinical research of the relationship between plantar fasciitis and gastrocnemius contracture

    Institute of Scientific and Technical Information of China (English)

    王海有; 张建中; 金合

    2012-01-01

    目的 研究跖腱膜炎与腓肠肌挛缩的关系.方法 对2010年9月~2010年1 1月足踝外科门诊收治的20人跖腱膜炎患者和31人正常足进行对比研究.结果 29足跖腱膜炎中16例(55.2%)合并腓肠肌挛缩.62正常足中 11例(17.7%)合并腓肠肌挛缩.结论 跖腱膜炎与腓肠肌挛缩关系密切,跖腱膜炎的患者多伴有腓肠肌挛缩.%Objective To study the relationship between plantar fasciitis and gastrocnemius contracture. Methods 20 outpatients with plantar fasciitis were compared with 31 normal people during Sep to Nov 2010 in Foot and ankle surgery department of Tongren hospital. Results 16 of 29 feet with plantar fasciitis ( 55.2% )had gastrocnemius contracture compared with 11 of 62 normal feet ( 17.7% ). Conclusion There is a close relationship between plantar fasciitis and gastrocnemius contracture. A plantar fasciitis patient is more likely to suffer gastorcnemius contracture.

  6. Personality and Sibling Relationships.

    Science.gov (United States)

    Furman, Wyndol; Lanthier, Richard P.

    1996-01-01

    This study examined the role personality variables play in sibling relationships. It proposed that the characteristics of sibling relationships are influenced by: family constellation variables such as birth order, gender, and age spacing; parent-child relationships including quality of relationship and parent management of siblings; and the…

  7. 临床心灵关怀对住院肿瘤患者满意度及医患关系的影响%Effect of Clinical Spiritual Care on Patient Satisfaction and Doctor-patient Relationship in Tumor Inpatients

    Institute of Scientific and Technical Information of China (English)

    梁英; 谌永毅; 汤新辉; 徐慧兰; 陈继萍; 陈武朝

    2012-01-01

    目的 探讨临床心灵关怀对住院肿瘤患者满意度及医患关系的影响. 方法 本次调查研究的301名住院肿瘤患者根据是否接受过临床心灵关怀将其分为对照组(未接受临床心灵关怀)167例和观察组(接受过临床心灵关怀)134例.对照组给予常规护理,观察组在常规护理基础上进行心灵关怀护理,并采用住院患者满意度量表及自编医患关系评价问卷对两组患者进行问卷调查. 结果 观察组的就医满意度和对医患关系积极评价的比例明显高于对照组(P<0.05),观察组对医生的满意度为95.2%,对照组对医生的满意度为85.8%;观察组认为医患关系和谐的比例为80.8%,对照组为67.9%. 结论 心灵关怀能提高住院肿瘤患者的就医满意度,对构建和谐医患关系及促进患者早日康复有积极作用.%Objective To explore the influence of clinical spiritual care on patient satisfaction and doctor - patient relationship among tumor inpatients. Methods Three hundred and one inpatients with tumor were divided into control group (without clinical spiritual care, n= 167) and observation group (with clinical spiritual care, n= 134). The patients of control group were given routine nursing care after surgery, while the patients of observation group received clinical spiritual care on the basis of conventional care. The inpatient satisfaction questionnaires and self - designed doctor - patient relationship evaluation questionnaires were used to survey the patients in both groups. Results The degree of patient satisfaction and the proportion of positive evaluation on doctor - patient relationship in observation group were significantly higher than those in control group (P < 0.05 ). The patient satisfaction rates of observation group and control group were 95.2 % and 85.8 % , respectively. The proportions of considering harmonious doctor - patient relationship in observation group and control group were 80.8

  8. Molecular epidemiology and genetic diversity of Listeria monocytogenes isolates from a wide variety of ready-to-eat foods and their relationship to clinical strains from listeriosis outbreaks in Chile

    Science.gov (United States)

    Montero, David; Bodero, Marcia; Riveros, Guillermina; Lapierre, Lisette; Gaggero, Aldo; Vidal, Roberto M.; Vidal, Maricel

    2015-01-01

    Listeria monocytogenes is a pathogen transmitted through food that can cause severe infections in high-risk groups such as pregnant women, elderly, young children and immunocompromised individuals. It is a ubiquitous bacterium that can survive in harsh conditions, such as dry environments, at low temperatures, in brine conditions and at low pH values. It also has the capacity to form biofilms, which makes it particularly successful even in colonizing surfaces within food processing plants. This study analyzed the presence of L. monocytogenes in ready-to-eat food (RTE) such as sausage, cheese, fresh salads, and other types of raw food. 850 samples of refrigerated and packaged food collected in 2008 and 2009 were analyzed. It was found that 25% of these samples were contaminated with L. monocytogenes strains. Serotyping and virulence genes detection by polymerase chain reaction (PCR) identified that strains belonging to serotype 4b, and containing one or more genes encoded by pathogenicity island (LIPI-1), were significantly associated with specific food types. Furthermore, using pulse field gel electrophoresis (PFGE), it was possible to associate isolates from cheese with strains from clinical cases of listeriosis outbreaks that occurred during the same time period within the same geographic regions. In addition, a strong correlation was observed between isolates from frozen seafood and from clinical strains obtained from sporadic cases of listeriosis. In agreement with reports described in other countries, our results shown that Chilean strains of L. monocytogenes from food products include the most virulent serotypes, encoding for the main virulence genes of the LIPI-1, and were clonally related to clinical isolates from sporadic cases and outbreaks of listeriosis. In conclusion, we show that Chilean isolates of L. monocytogenes from RTE and raw food products can cause disease in humans, representing a public health risk that justifies permanent surveillance. PMID

  9. Molecular epidemiology and genetic diversity of Listeria monocytogenes isolates from a wide variety of ready-to-eat foods and their relationship to clinical strains from listeriosis outbreaks in Chile.

    Directory of Open Access Journals (Sweden)

    David eMontero

    2015-04-01

    Full Text Available Listeria monocytogenes is a pathogen transmitted through food that can cause severe infections in high-risk groups such as pregnant women, elderly, young children and immunocompromised individuals. It is a ubiquitous bacterium that can survive in harsh conditions, such as dry environments, at low temperatures, in brine conditions and at low pH values. It also has the capacity to form biofilms, which makes it particularly successful even in colonizing surfaces within food processing plants. This study analyzed the presence of L. monocytogenes in ready-to-eat food (RTE such as sausage, cheese, fresh salads and other types of raw food. 850 samples of refrigerated and packaged food collected in 2008 and 2009 were analyzed. It was found that 25% of these samples were contaminated with L. monocytogenes strains. Serotyping and virulence genes detection by polymerase chain reaction (PCR identified that strains belonging to serotype 4b, and containing one or more genes encoded by LIPI-1, were significantly associated with specific food types. Furthermore, using pulse field gel electrophoresis (PFGE, it was possible to associate isolates from cheese with strains from clinical cases of listeriosis outbreaks that occurred during the same time period within the same geographic regions. In addition, a strong correlation was observed between isolates from frozen seafood and from clinical strains obtained from sporadic cases of listeriosis. In agreement with reports described in other countries, our results shown that Chilean strains of L. monocytogenes from food products include the most virulent serotypes, encoding for the main virulence genes of the LIPI-1 pathogenicity island, and were clonally related to clinical isolates from sporadic cases and outbreaks of listeriosis. In conclusion, we show that Chilean isolates of L. monocytogenes from RTE and raw food products can cause disease in humans, representing a public health risk that justifies permanent

  10. Study on the Clinical Relationship between Blood Glucose, Glycated Hemoglobin Level and Acute Cerebral Infarction%血糖、糖化血红蛋白水平与急性脑梗死临床关系的探讨

    Institute of Scientific and Technical Information of China (English)

    袁勇

    2012-01-01

      Objective To investigate acute patient of brain infarct blood sugar competence and clinical relation. Methods Empty stomach blood sugar level when admitting to hospital divide into normal blood sugar group,high blood sugar group, at random according to patient, Before treating, after treating,flawed or damaged to go on and give a mark to nervous system,Observe blood sugar, glycosylated hemoglobin have illness coming on the total mark and clinical relation. Results Acute brain infarct blood sugar level high,and have illness coming on and flawed or damaged to give a mark either high nervous system of patient,the worse its clinical curative effect is. Conclusion High bloods sugars accompany high glycosylated hemoglobin increase acute brain nervous system of infarct damage especially with have illness coming on. Lower candy treatment may improve acute brain clinical curative effect of infarct effectively,Prevent and treat high blood sugar to prevent brain infarct effective measure one of actively.%  目的探讨血糖、糖化血红蛋白水平与急性脑梗死患者的临床关系。方法对收治的78例急性脑梗死患者的临床资料进行回顾性分析,根据入院时空腹血糖水平分为正常血糖组、高血糖组,病情好转后对所有患者进行神经系统缺损评分,观察血糖、糖化血红蛋白和临床的关系。结果急性脑梗死患者高血糖组与正常血糖组相比,其神经系统缺损评分高,总有效率低。结论高血糖尤其伴高糖化血红蛋白会增加急性脑梗死神经系统损伤,预后差。故积极预防和治疗高血糖是预防脑梗死的有力措施之一。

  11. How will e-health affect patient participation in the clinic? A review of e-health studies and the current evidence for changes in the relationship between medical professionals and patients.

    Science.gov (United States)

    Dedding, Christine; van Doorn, Roesja; Winkler, Lex; Reis, Ria

    2011-01-01

    In this report we discuss the consequences of e-health for patient-clinician encounters. On the basis of an analysis of the literature, we propose an analytical framework, composed of five different themes, regarding the impact of e-health on the relationship between patients and their health professionals. Internet health sites can: be or come to be a replacement for face-to-face consultations; supplement existing forms of care; create favorable circumstances for strengthening patient participation; disturb relations; and/or force or demand more intense patient participation. Though there is as yet insufficient empirical evidence supporting these effects, we believe that distinguishing the proposed themes will help to guide an in-depth discussion and further research. We conclude that in particular the redistribution of tasks and responsibilities to patients in their daily lives requires more attention in future research.

  12. The relationship between adherence to clinic appointments and year-one mortality for newly enrolled HIV infected patients at a regional referral hospital in Western Kenya, January 2011-December 2012.

    Science.gov (United States)

    Kimeu, Muthusi; Burmen, Barbara; Audi, Beryl; Adega, Anne; Owuor, Karen; Arodi, Susan; Bii, Dennis; Zielinski-Gutiérrez, Emily

    2016-01-01

    This retrospective cohort analysis was conducted to describe the association between adherence to clinic appointments and mortality, one year after enrollment into HIV care. We examined appointment-adherence for newly enrolled patients between January 2011 and December 2012 at a regional referral hospital in western Kenya. The outcomes of interest were patient default, risk factors for repeat default, and year-one risk of death. Of 582 enrolled patients, 258 (44%) were defaulters. GEE revealed that once having been defaulters, patients were significantly more likely to repeatedly default (OR 1.4; 95% CI 1.12-1.77), especially the unemployed (OR 1.43; 95% CI 1.07-1.91), smokers (OR 2.22; 95% CI 1.31-3.76), and those with no known disclosure (OR 2.17; 95% CI 1.42-3.3). Nineteen patients (3%) died during the follow-up period. Cox proportional hazards revealed that the risk of death was significantly higher among defaulters (HR 3.12; 95% CI 1.2-8.0) and increased proportionally to the rate of patient default; HR was 4.05 (95% CI1.38-11.81) and 4.98 (95% CI 1.45-17.09) for a cumulative of 4-60 and ≥60 days elapsed between all scheduled and actual clinic appointment dates, respectively. Risk factors for repeat default suggest a need to deliver targeted adherence programs.

  13. Relationship among hardiness, perceived organizational support and work engagement of clinical nurses%临床护士人格坚韧性、组织支持感与工作投入关系的探讨

    Institute of Scientific and Technical Information of China (English)

    王雪; 尹吉善; 崔文香

    2013-01-01

    目的 了解临床护士工作投入的现状,探讨人格坚韧性、组织支持感与工作投入间的关系,为提高临床护士的工作投入水平提供依据.方法 采用工作投入量表、人格坚韧性量表、组织支持感量表对630名临床护士进行调查,并对结果进行分析.结果 工作投入总分为(52.54±8.08)分、人格坚韧性总分为(70.09±14.44)分,组织支持感总分为(82.41±24.98)分.临床护士的人格坚韧性、组织支持感、工作投入两两间均呈显著性正相关.回归分析显示,控制人口学变量后,人格坚韧性、组织支持感分别作为自变量对工作投入有显著正向预测作用.结论 医院管理者应为临床护士创造正性工作环境,从个体和组织层面采取相应措施,提高临床护士人格坚韧性和组织支持感,增进临床护士的工作积极性,从而使护士更好地投入工作.这对提高护理服务质量,稳定护理队伍具有重要的现实意义.%Objective To know about the current status of the work engagement of the clinical nurses,and discuss the relatioaships among hardiness,perceived organizational support and work engagement so as to provide basis for improving the level of the work engagement of the clinical nurses.Methods The work engagement scale,hardiness scale and perceived organizational support scale were used to investigate a total of 630 clinical nurses.Results The general score of work engagement,hardiness and perceived organizational support were showed respectively as following:(52.54±8.08),(70.09±14.44) and(82.41±24.98).Every two items of hardiness,perceived organizational support and work engagement were in significant positive correlation.Regression analysis showed after the variable of demographic was controlled,the hardiness and perceived organizational support respectively had significant positive predictive function on work engagement as respective independent variables.Conclusions Hospital managers should

  14. Relationship between clinical and postmortem evaluation in repeat breeder beef cows Relação entre características clínicas e post-mortem em vacas de corte repetidoras de serviço

    Directory of Open Access Journals (Sweden)

    Rogério Ferreira

    2008-08-01

    Full Text Available The objective of this study was to investigate the causes of the repeat breeder syndrome comparing clinical signs and postmortem findings in beef cows. The identification of factors affecting the reproductive tract can support decisions as to whether treatment of repeat breeder cows is justifiable than culling. Since all animals were submitted to clinical examination before being slaughtered, this study has a differential approach when compared with others, where genital tracts from abattoir were examined. In this study, 130 crossbred cows and heifers that have failed to conceive after three or more services were identified, submitted to a clinical examination and blood collection for karyotyping and sent to an abattoir. postmortem examinations included macroscopic evaluation of the genital tracts, bacteriology and histopathology of the uterus. Uterine alterations were predominant followed by oviduct and ovarian pathologies. Histopathological examination was more sensitive as a diagnostic tool than clinical examination. Repeat breeder cows had a predominance of uterine abnormalities (95%, such as inflammatory (42.9% and degenerative (59.7% conditions. Oviduct abnormalities were found in 29.8 % of animals. Furthermore, 1 out 10 karyotyped cows showed aneuploidy. Thus, this study stressed the importance of laboratory exams in the diagnosis of the causes of infertility of repeat breeder cows.O objetivo deste estudo foi avaliar as causas de infertilidade em vacas de corte repetidoras de serviço, relacionando sinais clínicos com características laboratoriais post-mortem. A identificação dos fatores que afetam o desempenho reprodutivo pode fornecer uma fundamentação científica para auxiliar na decisão quanto ao destino de vacas repetidoras de serviço; tratamento ou descarte. Este estudo tem abordagem diferencial dos trabalhos que contemplam somente a ocorrência de alterações post-mortem do trato genital. A correlação das altera

  15. The relationship between adherence to clinic appointments and year-one mortality for newly enrolled HIV infected patients at a regional referral hospital in Western Kenya, January 2011–December 2012

    Science.gov (United States)

    Kimeu, Muthusi; Burmen, Barbara; Audi, Beryl; Adega, Anne; Owuor, Karen; Arodi, Susan; Bii, Dennis; Zielinski-Gutiérrez, Emily

    2016-01-01

    This retrospective cohort analysis was conducted to describe the association between adherence to clinic appointments and mortality, one year after enrollment into HIV care. We examined appointment-adherence for newly enrolled patients between January 2011 and December 2012 at a regional referral hospital in western Kenya. The outcomes of interest were patient default, risk factors for repeat default, and year-one risk of death. Of 582 enrolled patients, 258 (44%) were defaulters. GEE revealed that once having been defaulters, patients were significantly more likely to repeatedly default (OR 1.4; 95% CI 1.12–1.77), especially the unemployed (OR 1.43; 95% CI 1.07–1.91), smokers (OR 2.22; 95% CI 1.31–3.76), and those with no known disclosure (OR 2.17; 95% CI 1.42–3.3). Nineteen patients (3%) died during the follow-up period. Cox proportional hazards revealed that the risk of death was significantly higher among defaulters (HR 3.12; 95% CI 1.2–8.0) and increased proportionally to the rate of patient default; HR was 4.05 (95% CI1.38–11.81) and 4.98 (95% CI 1.45–17.09) for a cumulative of 4–60 and ≥60 days elapsed between all scheduled and actual clinic appointment dates, respectively. Risk factors for repeat default suggest a need to deliver targeted adherence programs. PMID:26572059

  16. 精神分裂症智能损害与脑萎缩的关系探讨%A Clinical Study on Relationship between Intelligence Impairment and Brain Atrophy in Schixophrenia

    Institute of Scientific and Technical Information of China (English)

    高镇松; 林和文

    2003-01-01

    Objective To explore the relationship between intelligence impairment and brain atro-phy in schixophrenia. Methods 34 cases with schizophrenia were tested intelligence with WAIS-RC andwere examined brain CT. Then, according to CT results, all the subjects were classified into two grups-the brain atrophy group with 28 patients (about 82%) and the non-brain atrophy group with 6 cases(about 18%). The intelligence of the two groups were compared with each other with the control ofnorms. At the same time, the conditions of brain atrophy in different levels were analyzed. Results Thebrain atrophy group showed obviously more intelligence impairment. The lower the intelligent level was ,the higher the incidence of brain atrophy showed, and the severer and broader the brain atrophy was suchas ventricle broadenness, fissure widenness, sulci deeepenness, even the whole brain atrophy.Conclusions There was close relationship between intelligence impairment and brain atrophy in schixo-phrenia. This suggested that the schizophrenics with intelligence impairment existed the basis of brainorganic impairment.%目的探讨精神分裂症智能损害与脑萎缩的关系.方法应用WAIS-RC对34例精神分裂症患者进行智力测验,然后按CT结果分为脑萎缩组28例(82%)和非脑萎缩组6例(18%),分别进行智力测验比较并与常模对照,同时分析不同智力水平脑萎缩的情况.结果脑萎缩组的智能损害更明显、智力水平越低、脑萎缩的发生率越高、程度越重、分布越广(如脑室扩大、脑裂增宽、脑沟加深、甚至全脑萎缩).结论精神分裂症智能损害与脑萎缩关系密切,提示精神分裂症智能损害者存在脑器质损害基础.

  17. Clinical research on relevant relationship between cervical vertigo and instability and treatment based on differentiation in TCM%中药鼻饲防治心肺复苏后并发急性肾损伤体会

    Institute of Scientific and Technical Information of China (English)

    周燕红; 金晓玲; 朱丽娟

    2014-01-01

    目的:探讨中医药对心肺复苏后急性肾损伤的防治作用。方法:选取符合条件的心肺复苏后自主循环恢复的患者共23例,在常规进一步治疗的基础上,予中药汤剂鼻饲。结果:23例观察病例,有14例死亡,死亡率为60.9%,有6例发生AKI ,发生率为26.1%。结论:中药在防治心肺复苏后并发急性肾损伤可能有一定积极的意义。%Objective: To investigate the treatment based on differentiation in TCM through studying the relevant relationship between cervical vertigo and instability. Methods: 50 cases with cervical vertigo from January 2012 to January 2014 were selected, 31 cases of male patients and 19 cases of female patients. Age range was between 30-75, an average of 60.3 years old. All 50 cases of patients were analyzed on the the relevant relationship between cervical vertigo and instability and TCM differentiation in order to make sure the cervical instability and incidence of this disease. Patients were divided into a control group and a research group, the characteristic of the disease as well as the differences of classification in TCM were analyzed. Results: 30 patients in the control group had no cervical instability, the incidence was 0%, 50 cases of patients in the research group, 36 cases with cervical instability, the incidence was 72%. Neck 2-7 vertebral backup Angle of(6.75 ± 0.89). Conclusion:Cervical vertigo patients of cervical vertebral rear within 7 ° will not produce the prototype of vertigo. Treatment based on differentiation in TCM has a great effect.

  18. [The factor analysis results of the relationship of socio-demographic, clinical and functional indicators with the likelihood of identifying age-related disorders in the population in North-Western Russia].

    Science.gov (United States)

    Kupriianova, V A; Zakharchuk, A G; Zherebtsov, S V; Spivak, I M; Spivak, D L

    2013-01-01

    By using the method of factor analysis (principal component method) the determinants of disease in elderly and senile patients were searched with an estimate of their influence degree in the population of the North-West Russia. The data from medical records of 712 patients of both sexes aged 59 to 98 years were analyzed. The factor 1 proved to be associated with: marital status, living conditions, family relationships, bad habits, appearance, cough, diet, hearing and vision, laxatives, joint health, ability to move and sleep disturbances. Factor 2 combined diseases of older: cerebral stroke, myocardial infarction, cardiac arrhythmia, diabetes, kidney disease, obesity, thyroid disease, Parkinson's disease, lung disease, anemia, arthritis, osteoporosis, the number of surgeries and joint diseases. The factor 3 was found to self-association ability before and after admission to the assessment of the patients' mental state for MMSE test after admission. It is concluded that the development of age-related (especially the musculoskeletal system pathology) is associated with social characteristics and living conditions of patients, and treatment of the most age-related diseases requires consideration of comorbidity.

  19. Ancestral Relationships Using Metafounders

    DEFF Research Database (Denmark)

    Legarra, Andres; Christensen, Ole Fredslund; Vitezica, Zulma G

    2015-01-01

    due to finite size of the ancestral population and connections between populations. This complicates the conciliation of both approaches and, in particular, combining pedigree with genomic relationships. We present a coherent theoretical framework to consider base population in pedigree relationships....... We suggest a conceptual framework that considers each ancestral population as a finite-sized pool of gametes. This generates across-individual relationships and contrasts with the classical view where each population is considered as an infinite, unrelated pool. Several ancestral populations may......Recent use of genomic (marker-based) relationships shows that relationships exist within and across base population (breeds or lines). However, current treatment of pedigree relationships is unable to consider relationships within or across base populations, although such relationships must exist...

  20. Relationship between quality of life and clinical status in patients with gastrointestinal cancer Relación entre calidad de vida y estadio clínico en pacientes con cáncer gastrointestinal

    Directory of Open Access Journals (Sweden)

    Ricardo Sánchez

    2012-12-01

    Full Text Available Background: previous studies with patients having cancer have shown that quality of life scores depend on the clinical stage of the disease (the more advanced the disease, the worst quality of life. Methods: in a prospective study we studied 317 patients with gastric or colorectal cancer attending the Instituto Nacional de Cancerología between 2010 and 2011; the patients completed the EORTC QLQ-C30 before receiving treatment. This instrument measures quality of life in 15 domains. Scores of each domain were compared according to tumor stage. Differential Item Functioning was measured across neoplasm staging and tumor localization. Results: 145 patients (45.7% were diagnosed with colorectal cancer. According to clinical staging, differences in quality of life scores were observed in 4 of 15 domains (physical and social functioning, anorexia. Most of the differences in quality of life domains depended on tumor localization (patients with colorectal cancer had the highest scores in quality of life and sex (women reported better scores. These differences seemed to be independent of item properties. The construct was more adequately measured with items that explore the construct using a general approach. Conclusion: in this group of patients with colorectal and gastric cancer quality of life scores were more related with tumor localization than with clinical stage.Introducción: la calidad de vida de pacientes con cáncer varía según el estadio clínico de la enfermedad, siendo peor en estadios avanzados. Métodos: estudio prospectivo en el que se evaluaron 317 pacientes con cáncer colorrectal o gástrico que asistieron al Instituto Nacional de Cancerología durante los años 2010 y 2011 y que no habían iniciado tratamiento. Se utilizó el cuestionario EORTC QLQ C-30, un instrumento que mide calidad de vida en 15 dominios. Se compararon las puntuaciones para cada dominio según el estadio tumoral. Adicionalmente se realizó un análisis de

  1. Clinical Congenital Middle Ear Malformation and Its Relationship with Hearing Loss%先天性中耳畸形的临床分型及其与耳聋的相关性研究

    Institute of Scientific and Technical Information of China (English)

    王霞

    2015-01-01

    目的:探讨先天性中耳畸形的临床分型及其与耳聋的相关性。方法将我院入院治疗的42例(62耳)先天性中耳畸形患者纳入本研究,对本组患者均进行详细的手术检查,分析患者中耳畸形状态。结果经过记性检查,可能有听骨链畸形表现,还有面神经骨管暴露与面神经异常的表现。本组听力学检查结果显示本组患者主要为锤砧骨畸形(31例),11例未蜗窗畸形与前庭窗畸形,11例患者畸形程度相对复杂,伴随走形异常与面神经结构异常。结论先天性中耳畸形根据其组织的来源,可以分为不同的类型,在临床研究中需要分析高频与听阈问题,结合CT检查结果与骨导变化结果进行分析,这能够为合理手术提供合理的临床依据,提升治疗的安全性。%Objective To investigate the correlation between the clinical classification of congenital malformation of the middle ear and hearing loss.Methods In our hospital, 42 cases of hospitalized patients (62 ears) were included in the study of patients with congenital malformation of the middle ear, for this group of patients were examined with the operation, analysis of patients with middle ear malformation state.Results after a check, there may be the ossicular chain deformity, and facial nerve canal and facial nerve exposed to abnormal performance. Results Showed that the group of audiological examination were mainly for the hammer incus deformity (31 cases), 11 cases without cochlear window deformity and vestibular window deformity, 11 cases of patients with deformity complicated with abnormal shape, facial nerve and abnormal structure.Conclusion Congenital middle ear malformation according to the source of its organization, can be divided into different types, in clinical research needs analysis of high frequency and threshold problem, combined with the results of CT and bone changes were analyzed, which can provide the basis for

  2. Study on relationship between employment pressure and professional self-concept of nursing students in clinical practice%临床实习护生就业压力与专业自我概念的关系研究

    Institute of Scientific and Technical Information of China (English)

    吕芳菲; 李春芳

    2011-01-01

    Objective:To investigate the employment pressure and professional self - concept of nursing students in clinical practice, and know about the correlation between them, so as to provide theoretical evidences for the employment guidance for nursing students. Methods: A total of 171 nursing students were investigated by using the self - made general situation questionnaire, college students employment pressure questionnaire and nursing professional self - concept scale. Results:The total score of employment pressure of nursing students in the clinical internship was(2. 75 + 0. 67) ,6 factors scores from high to low by turns respectively were Lack of job search assistance, employment competition environment, employment psychological expectations, contradiction between professional supply and demand, professional quality evaluation and self - awareness and positioning; in the general information, the family economic status and learning achievement were the major factors influencing the employment pressure; the professional self -concept score of nursing students was (2. 83 + 0. 46), wherein the flexibility score was the highest, satisfaction score was the lowest; in the general information, the learning achievement was the main factor affecting the professional self - concept; nursing students' employment pressure level was negatively correlated with professional self - concept(Pclinical practical nursing students may influence the employment stress, hospitals should actively cultivate students good professional self - concept, and take corresponding measures to alleviate the employment pressure of nursing students, so as to help them employment smoothly.%[目的]调查实习护生的就业压力与专业自我概念水平,了解二者的相关性,为护生的就业指导提供理论依据.[方法]采用自制一般情况调查表、大学生就业压力问卷和护理专业自我概念量表对171名

  3. Clinical Trials

    Science.gov (United States)

    ... they are receiving. Other clinical trials involve a crossover design, where participants are randomly assigned to take a new treatment, a treatment already in use, and/or a placebo for a specified time ... If I am involved in a "crossover" clinical trial, can I go back to the ...

  4. 桥本氏病与甲状腺癌的关系探讨(附3例临床分析)%The relationship between Hashimoto's disease and thyroid cancer (3 cases of clinical analysis)

    Institute of Scientific and Technical Information of China (English)

    陈珂; 张飞; 冰峰

    2015-01-01

    目的 探讨我院慢性淋巴细胞性甲状腺炎(CLT)合并甲状腺癌的发病率及CLT合并甲状腺癌的临床诊断、治疗及预后.方法 回顾分析性我科2011年10月至2013年9月期间3例CLT合并甲状腺癌的临床资料.结果 本组CLT合并甲状腺癌的发生率为2.4%(3/125).术前正确诊断率为27.88%.超声提示 患者均伴有甲状腺结节及钙化.本组患者均行手术治疗,效果良好.结论 CLT可能是甲状腺癌的前期病变.对CLT合并甲状腺结节者应考虑手术治疗,尤其术前超声提示钙化者.对于CLT合并甲状腺癌的手术应采取甲状腺癌根治性手术的原则进行手术.%Objective: To investigate the hospital with chronic lymphocytic thyroiditis (CLT) combined incidence of thyroid cancer and the clinical diagnosis of thyroid cancer CLT merger, treatment and prognosis.Methods:A retrospective analysis of clinical data of our department from October 2011 to September 2013 during the three cases CLT with thyroid cancer.Results:The incidence of thyroid cancer in the combined group CLT was 2.4% (3/125). Preoperative diagnostic accuracy was 27.88%. Ultrasonic Tip patients with thyroid nodules and calcification. This group of patients underwent surgery with good results.Con-clusion:CLT could be thyroid cancer precursor lesions. CLT combined for thyroid nodules should consider surgery, especially preoperative ultrasound prompted calcification. For CLT with thyroid cancer thyroid cancer surgery should take the principles of radical surgery for surgery.

  5. Managing intimate interracial relationships

    OpenAIRE

    Okitikpi, Oluwatoyin

    2002-01-01

    This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University. It is evident that there is fairly widespread disapproval of intimate interracial relationships. This thesis explores the experiences of those involved in such relationships, how they manage their relationships, and the kind of pressures they confront. It considered the ways in which the reactions and attitudes of significant others and strangers impact upon such relationships and...

  6. 高尿酸血症与代谢综合征各组分关系的临床研究%The clinical research of the relationship between high uric acid hematic disease and metabolic syndrome various components

    Institute of Scientific and Technical Information of China (English)

    林丹; 郑禄城; 许晓玲

    2011-01-01

    Objective: To study the relationship between high uric acid hematic disease and the metabolic syndrome various components.Methods: To choose 1 000 people who took diabetes screening in the endocrine department of our hospital strict as the research object, of which 258 people with metabolic syndrome as the observation group, 742 cases without metabolic syndrome as control group, to measure and compare the blood glucose, blood pressure, cholesterol, triglycerides,high-density lipoprotein cholesterol, blood uric acid and height, weight waistline of the two groups.Results: The blood glucose, blood pressure, cholesterol, triglyeerides waist circumference and body mass index of the observation group were significantly higher than those in the control group, and the indicators of the group of high blood uric acid were significantly higher than the group with normal blood uric acid, and with or without metabolic syndrome, the blood uric acid level of the male were significantly higher than women, the difference was statistically significant(P<0.05).Conclusion: The relationship of high uric acid hematic disease and the each composition of metabolic syndrome were close, by monitoring the blood uric acid level could provide important theory basis for cardiovascular disease prevention and control and early forecast.%目的:探讨高尿酸血症与代谢综合征各组分的关系.方法:严格筛选我院内分泌科门诊进行糖尿病筛查的1 000例作为研究对象,其中代谢综合征患者258例为观察组,无代谢综合征742例为对照组,对两组人群的血糖、血压、胆固醇、三酰甘油、高密度脂蛋白、血尿酸及身高、体重、腰围进行测定,并进行比较分析.结果:观察组血糖、血压、胆固醇、三酰甘油及腰围、体重指数均显著高于对照组,且高血尿酸组各项指标均明显高于血尿酸正常人群,且无论有无代谢综合征,男性血尿酸水平明显高于女性,差

  7. Clinical observation of the relationship between primary progressive pterygium and dry eye%原发性进展性翼状胬肉和干眼的相关性临床观察

    Institute of Scientific and Technical Information of China (English)

    李妍; 王萍; 秦莉

    2015-01-01

    Objective To observe the relationship between primary progressive pterygium and dry eye.Methods Totally 45 cases of primary progressive pterygium diagnosed in our hospital from July 2013 to July 2014 were enrolled.The pterygium eye was evaluated and the fellow eye served as control.Symptom scores, tear film break-up time ( BUT), Schirmer I test, Fluorescent staining, and the prevalence of dry eye were examined and compared.Results BUT were shorter in pterygium eye than in fellow eye ( P <0.05).Symptom scores and the fluorescent staining scores were higher ( P <0.05) .Schirmer I test showed no significant difference between the two eye, but the prevalence of dry eye was signifi-cantly different ( P <0.05).Conclusion Primary progressive pterygium may decrease constancy of tear film and cause the corneal epithelium damage and dry eye syndrome;there is a close relationship between it and dry eye syndrome.%目的:探讨原发性进展性翼状胬肉和干眼的相关性。方法选取西安市第四医院眼科门诊2013年7月至2014年7月45例确诊原发性进展性翼状胬肉患者,进行回顾性研究,以翼状胬肉眼位观察组,对侧眼为对照组,分别检查干眼主观症状评分、泪膜破裂时间( BUT)、基础泪液分泌试验( SIt)、角膜荧光染色评分( FL)和干眼患病率,对数据进行统计学分析。结果观察组的BUT较对照组缩短,差异有统计学意义( P <0.05),干眼主观症状评分和FL高于对照组,差异有统计学意义( P <0.05),观察组的SIt较对照组缩短,差异无统计学意义( P >0.05),干眼的患病率比较差异有统计学意义( P <0.05)。结论原发性进展性翼状胬肉降低泪膜稳定性,引起角膜上皮损伤和干眼症,增加干眼的患病率,两者之间关系密切,互相影响。

  8. Building Relationships through Exchange

    Science.gov (United States)

    Primavera, Angi; Hall, Ellen

    2011-01-01

    From the moment of birth, children form and develop relationships with others in their world based on exchange. Children recognize that engaging in such encounters offers them the opportunity to enter into a relationship with another individual and to nurture that relationship through the exchange of messages and gifts, items and ideas. At Boulder…

  9. Intimate Relationships and Psychopathology

    Science.gov (United States)

    Whisman, Mark A.; Baucom, Donald H.

    2012-01-01

    Relationship functioning and individual mental health and well-being are strongly associated with one another. In this article, we first review the cross-sectional and longitudinal associations between relationship discord and various types of psychopathology, We then review findings suggesting that relationship discord is associated with poorer…

  10. 颅脑损伤GCS评分与CT像计分与临床预后的相关性研究%The relationships of GCS score and CT score in clinical prognosis in patients with craniocerebral injury

    Institute of Scientific and Technical Information of China (English)

    余大超

    2015-01-01

    Objective To investigate the correlation between GCS score, CT score and the clinical prognosis in patients with craniocerebral injury, and to provide reference for clinical judgment of prognosis of patients with craniocerebral injury.Methods 138 patients with craniocerebral injury were randomly selected.All patients underwent head CT continuous scanning and CT Score.Accord-ing to the results, the patients were divided into mild group ( CT score less than or equal to 5 points, 58 cases) , medium group ( CT score 6~10 points, 49 cases) and severe group ( CT score more than or equal to 11 points, 31 cases) .The GCS and prognosis were compared and analyzed as well.Results The GCS score of patients with mild coma (56 case), moderate coma (50 cases) and se-vere coma score (32 case)has no significant difference with CT score, respectively ( t =5.234, P >0.05).But with the CT like score increased, GCS score decreased, there was significant correlation between the two (r=-0.73, P <0.05).After treatment, 52 patients of 58 cases with CT like scoring as light patientswere cured, only mild disability or no obvious dysfunction, accounting for 89. 66%;34 patients of 49 cases of CT score as medium-sized patients were cured, only mild disability or no obvious dysfunction in 31 cases, accounting for 57.63%;as for the patients with severe CT score, 12 patients were cured, only mild disability or no obvious dys-function, accounting for 38.71%, a significant difference between the two groups( P <0.05), which suggesting that CT like the score and the clinical prognosis of patients with craniocerebral injury were significantly positively correlated( r =0.37, P <0.05).Conclu-sion Craniocerebral injury with GCS score and CT score are significantly correlated.There is a significant correlation between CT like score and clinical prognosis, and GCS score and CT score can provide scientific reference for the prognosis.%目的:探讨颅脑损伤GCS评分与CT像计分与临床预后的相

  11. The clinical method and the scientific method

    Directory of Open Access Journals (Sweden)

    José Arteaga Herrera

    2010-12-01

    Full Text Available This paper is the chapter dedicated to the scientific method and the clinical method in the authors’ Handbook “Teaching of Clinics”. Philosophycal principles of the scientific method and its stages are presented as well as the clinical method as a scientific one and its stages. A relationship between the clinical method and the medical record is established, the role of technology in the clinical method is stated and the most frequent mistakes when applying it in clinical practice are provided. Finally, the teaching of the clinical method and the appropriate settings to do it are discussed.

  12. 绞窄性肠梗阻手术时机与临床指标的相关性%Relationship between Operation Timing and Clinical Criteria in Intestinal Obstruction

    Institute of Scientific and Technical Information of China (English)

    郭科; 封光华; 贾忠

    2011-01-01

    Objective To investigate the reliable indicators of operation timing of strangulated intestinal obstruction. Methods A retrospective study of 65 patients with simple intestinal obstruction and 55 patients with strangulated intestinal obstruction was done.. All patients were confirmed by operation. Indicators including body temperature, pulse abdominal pain, abdominal distension, result of peritoneocentesis, leukocyte count, C-reactive protein, D-dimer, CT finding and shock were observed and recorded. Te relationship between the indicators and the operation timing of strangulated intestinal obstruction was analyzed with SPSS statistical analysis software package. Results In simple intestinal obstruction group, three patients (4.62%) met two of the above indicators and nobody met three or more of the above indicators. In strangulated intestinal obstruction group,twenty patients (36.36%) met two of the above indicators and twenty five (45.45%) patients met three or more of the above indicators, Conclusion Once a patient with intestinal obstruction meet two or more of the above indicators, he or she most likely has strangulated occurred, hence the patients should be treated carefully and operated in time.%目的:探讨绞窄性肠梗阻判断手术时机的临床可靠指标.方法:回顾性分析经手术证实的急性非绞窄性肠梗阻(65例)及绞窄性肠梗阻(55例)患者的相关临床资料,观察体温、脉搏、腹痛、腹胀、腹腔穿刺、白细胞计数、C-反应蛋白、D-二聚体、CT表现、休克情况等,并与手术时机之间的相关性进行分析.结果:急性非绞窄性肠梗阻患者符合相关指标中2项的3例(4.62%),绞窄性肠梗阻符合相关指标2项的20例(36.36%),3项及3项以上的25例(45.45%).结论:肠梗阻患者如符合相关指标中的2项以上,则提示该患者极有可能为绞窄性肠梗阻,应高度重视并积极手术.

  13. Clinical Research

    DEFF Research Database (Denmark)

    Christensen, Irene

    2016-01-01

    This paper is about the logic of problem solving and the production of scientific knowledge through the utilisation of clinical research perspective. Ramp-up effectiveness, productivity, efficiency and organizational excellence are topics that continue to engage research and will continue doing s...... for years to come. This paper seeks to provide insights into ramp-up management studies through providing an agenda for conducting collaborative clinical research and extend this area by proposing how clinical research could be designed and executed in the Ramp- up management setting....

  14. 睑板腺功能障碍与血糖浓度及脂质代谢水平相关性研究%Clinical research of relationship between meibomian gland dysfunction and blood glucose concentration and lipid metabolism

    Institute of Scientific and Technical Information of China (English)

    李华; 乔丽萍; 王春娥; 王素莉; 沈继春; 赵季红; 陈慧鑫

    2016-01-01

    Objective To analyze the relationship between meibomian gland dysfunction and concentration of blood glucose and lipid metabolism.Methods A randomized and double-mask trial was conducted for 4 months duration.Eighty-four cases of diabetic patients (group A) and 35 controls without diabetic and with history of cardiovascular disease (group B),accrued from October 2014 to January 2015 were included.Group A was divided into group A1 and A2 according to whether with cardiovascular diseases,group A1 for diabetes with no cardiovascular disease; group A2 for diabetic combined cardiovascular disease.The relationship between meibomian gland dysfunction and concentration of blood glucose and lipid metabolism were analyzed.Results Meibomian gland dysfunction prevalence was 75% in diabetes patients.There were statistically significant difference between the groups A1 and group B,group A2 and group B,while no significant difference between the group A1 and group A2 on analysis of meibomian gland obstruction score.There were statistically significant between the group A2 and group B on analysis of quality of expressed meibum score,no significant difference among the other groups.In correlation analysis,the meibomian gland obstruction score was positively correlated with fasting glucose (P =0.006,rs =0.252),and the rest had no correlation.Conclusions The prevalence of meibomian gland dysfunction is up to 75% in diabetes patients,the concentration of fasting plasma glucose is a risk factor in diabetic patients with meibomian gland dysfunction development and adjustment of the concentration of fasting plasma glucose can help improvement of therapeutic effect in diabetic patients with meibomian gland dysfunction.%目的 探讨睑板腺功能障碍与血糖浓度及脂质代谢水平之间的相关性.方法 临床病例对照研究.收集2014年10月至2015年1月在辽宁医学院武警后勤学院附属医院的84例糖尿病患者为病例组(A组)(根据是

  15. The clinical significance of the relationship between HBV DNA Genotyping and HBV DNA YMDD mutation%乙肝病毒基因分型与YMDD变异的关系及其临床意义研究

    Institute of Scientific and Technical Information of China (English)

    董格峰; 丁艾昆; 孙玉秋; 王琰珉; 宁志杰

    2011-01-01

    Objective:To study the distribution of the hepatitis B virus genotypes in 579 cases with hepatitis B virus patients,and analysis its clinical significance. Methods: HBV genotypes were determined by Gene chip technology analysis in 579 cases from 2007.1 to 2009.12. The liver function detection is acquired by Enzyme Kinetics Abbott Ci8200. Results: Genotype C is the most frequent genotype of hepatitis B virus with statistical significance( P <0. 01 ). It is statistical significance between genotype C and genotype B, genotype C and genotype B/C, genotype B and genotype B/C (P < 0. 05 ). Conclusion:Genotype B, genotype C and genotype B/C exist in 1047 cases with hepatitis B virus patients, in which genotype C is the most frequent one. Genotype is associated with the development of liver disease. Among three genotypes, genotype B/C is correlated with the worst prognosis.%目的:研究乙肝患者HBV基因型的分布及临床意义.方法:采集济南市传染病医院2007年1月-2009年12月乙肝病毒感染者579例,采用基因芯片进行HBV基因分型,生化指标在酶动力学法雅培Ci8200全自动仪上测得.结果:在肝病患者中,B型99例(17.1%),C型468例(80.8%),B/C混合型12例(2.1%).C型在肝病患者基因型中所占构成比最高,差异有显著性(P0.05);不同基因型的CHE水平差异统计有显著性(P<0.01),B/C型最低,C型次之,B型最高.结论:乙肝患者其HBV基因型存在有B型、C型和B/C混合型;其中C型为优势基因型;不同基因型与肝脏的合成能力及预后有关,B型预后最好,B/C型最差.

  16. Relationship of clinical characteristics between eosinophils and chronic rhinosinusitis with nasal polyp%嗜酸性粒细胞与慢性鼻-鼻窦炎合并鼻息肉的临床特征的关系

    Institute of Scientific and Technical Information of China (English)

    石帅; 高下

    2016-01-01

    目的:探讨嗜酸性粒细胞(Eos)与慢性鼻-鼻窦炎伴鼻息肉(CRSwNP)的临床特征的关系。方法62例慢性鼻-鼻窦炎伴鼻息肉并行鼻内镜下鼻窦开放手术患者,根据外周血嗜酸性粒细胞比例,分为Eos组与正常密度嗜酸性粒细胞(NEos)组。比较两组患者鼻息肉组织嗜酸性粒细胞计数、鼻腔鼻窦结局测量20条(SNOT-20)评分以及鼻窦CT 的Lund-Mackay 评分等。结果Eos组鼻息肉组织中的嗜酸性粒细胞计数显著高于NEos组(P0.05),鼻息肉组织中嗜酸性粒细胞计数与SNOT-20评分无相关性(r=0.246,P=0.126>0.05);两组CT的Lund-Mackay评分比较差异有统计学意义(P0.05). Eosinophils count in polyp tissue and SNOT-20 was not correlated (r=0.246,P=0.126>0.05). The difference of CT Lund-Mackay scores had statistical significance between the two groups (P<0.05). Peripheral blood eosinophils proportion was positively correlated with histopathological outcome (r=0.512,P<0.05). Area under curve (AUC) of ROC was 0.808, with cutoff value as 3.65%. It contained sensitivity and specificity as 78.9% and 71.4% in diagnosis of eosinophils chronic rhinosinusitis with nasal polyp (ECRSwNP).Conclusion Eosinophils has effects on clinical characteristics of chronic rhinosinusitis with nasal polyp. It is necessary to pay attention to peripheral blood eosinophils proportion in diagnosing ECRSwNP, in order to make appropriate treatment strategy for patients.

  17. Clinical photography.

    Science.gov (United States)

    Jakowenko, Janelle

    2009-01-01

    Digital cameras, when used correctly, can provide the basis for telemedicine services. The increasing sophistication of digital cameras, combined with the improved speed and availability of the Internet, make them an instrument that every health-care professional should be familiar with. Taking satisfactory images of patients requires clinical photography skills. Photographing charts, monitors, X-ray films and specimens also requires expertise. Image capture using digital cameras is often done with insufficient attention, which can lead to inaccurate study results. The procedures in clinical photography should not vary from camera to camera, or from country to country. Taking a photograph should be a standardised process. There are seven main scenarios in clinical photography and health professionals who use cameras should be familiar with all of them. Obtaining informed consent prior to photography should be a normal part of the clinical photography routine.

  18. 耳鸣临床特征与主观心理严重程度的关系%The relationship between clinical characteristics of tinnitus and subjective psychology

    Institute of Scientific and Technical Information of China (English)

    王涂路; 李颖雯; 李松键; 冯娟

    2012-01-01

    目的 了解耳鸣匹配频率及听力下降的关系及THI和VAS对耳鸣患者评价的相关性.方法 对70例以主观性耳鸣为第一主诉的耳鸣患者了解病史,进行耳科常规检查及纯音听阈、耳鸣匹配检查,并由患者填写耳鸣残疾评估量表(tinnitus handicap inventory,THI)及视觉模拟量表(visual-analogue scale VAS),综合分析各项结果.结果 在70例耳鸣患者中高音调(4 000~8 000Hz)42例,中音调(1 000~3 000Hz)16例,低音调(125~750 Hz) 12例;其与患者听力下降的最高频率(rs=0.455,P=0.000)差异有统计学意义.而不同频率及响度大小与VAS和THI评分量表差异无统计学意义.结论 不同耳鸣的频率与听力下降最高频率具有相关性,VAS和THI评分量表两者具有相关性,二者与耳鸣的主频及响度相关性不大.%OBJECTIVE To know the relationship between tinnitus matching frequency and hearing loss, and the correlativity between THI and VAS to evaluate the tinnitus patients. METHODS 70 patients with the subjective tinnitus as the first chief complain were selected, and we performed the otology routine examination, pure-tone hearing threshold test, tinnitus matching test. The tinnitus handicap inventory and visual梐nalogue scales were completed by the patients, and finally we made a comprehensive analysis on the results. RESULTS There were 42 high-pitched (4 000-8 000 Hz) patients, 16 medium loudness (1 000-3 000 Hz) patients, 12 low in tune (125-7S0 Hz) patients among the 70 tinnitus patients; It had the statistical significance with the highest frequency (r, =0.455, P = 0.000) of the hearing loss patients, but different frequencies and loudness sizes havd no statistic significance of the THI and VAS rating scales. CONCLUSION Different tinnitus frequencies have the correlativity with the highest frequency of hearing loss; THI and VAS rating scales have correlativity, while the two rating scales have little relevance with tinnitus dominant frequencies

  19. Relationship of cytokine level with cancer cachexia and its clinical research%癌性恶病质与细胞因子相关性的临床研究

    Institute of Scientific and Technical Information of China (English)

    何文杰; 任宏轩; 王羽丰

    2011-01-01

    Objective To study the expression of cytokine in the cancer cachexia patients and to discuss the relationship with cancer cachexia. Methods To compare the IL-1 、IL-6 、TNF-α、IFN-γ levels with 80 cases patients of cancer cachexia 、40 cases healthy people and 40 cases patients of non-cancer cachexia. To oral medroxyprogesterone with the 80 cases patients of cancer cachexia and give the nutritional support of four weeks. Four weeks later, to detect the levels of IL-1 、IL-6 、TNF-α IFN-γand compare with pre-treatment. Results Compared cancer cachexia group with non-cancer cachexia group and healthy group, the levels of IL-1 、IL-6 、TNF-α 、IFN-γ increased. P < 0. 05 , there were significances in statistics; The 80 cases patients of cancer cachexia through four weeks treated. the levels of IL-1 、IL-6 、TNF-α 、IFN-γ decreased. P < 0. 05 , there were significances in statistics. Conclusion Cytokines are relevant to the cancer cachexia and playing an important role.%目的 探讨细胞因子在癌性恶病质患者中的表达情况及与癌性恶病质发生、发展的相关性.方法 对80例癌性恶病质患者、40例门诊体检的健康人和40例非恶病质癌症患者血清中的IL-1、IL-6、TNF-α、IFN-γ水平相互比较.对80例癌性恶病质患者,采用甲羟孕酮片及营养支持治疗4周后检测其血清中的IL-1、IL-6、TNF-α、IFN-γ水平,并与治疗前的水平进行比较.结果 癌性恶病质组与健康组、非恶病质癌症组比较,IL-1、IL-6、TNF-α、IFN-γ水平升高(P<0.05);癌性恶病质组治疗后IL-1、IL-6、TNF-α、IFN-γ水平下降(P<0.05).结论 细胞因子与癌性恶病质的发生、发展相关,并扮演着重要的角色.

  20. Clinic study on relationship between C-type natriuretic peptide level and various types of atrial fibrillation%C型利钠肽水平与心房颤动不同类型关系的临床研究

    Institute of Scientific and Technical Information of China (English)

    赵德生; 余建伟; 李海华; 伍弘智; 陈甜

    2014-01-01

    Objective To explore relationship between changes of plasma C-type natriuretic peptide(CNP)level and var-ious types of atrial fibrillation(AF). Methods The 135 atrial fibrillation out-patients or in-patients from October 2012 to October 2013 were divided into three groups:45 patients with permanent atrial fibrillation ,43 patients with persistent atrial fibrillation and the other 47 patients with paroxysmal atrial fibrillation;additionally,40 healthy physical examiners were selected as the control group. Enzyme-linked immunosorbent assay(ELISA) was adopted to detect plasmic CNP level,and ultrasonic cardiogram was ap-plied to measure cardiac structure. Results The plasmic CNP levels in AF groups [paroxysmal atrial fibrillation group was (26.46±9.32)pg/mL,persistent atrial fibrillation group was(30.98±12.20)pg/mL and permanent atrial fibrillation group was(70.62± 20.30)pg/mL] were significantly higher than those of the control group[(15.25±5.48) pg/mL] with statistically significant difference (P<0.05). The plasmic CNP level in the permanent atrial fibrillation group was significantly higher than that in the persistent and paroxysmal atrial fibrillation groups,and the difference was statistically significant(P<0.05). Conclusion The plasmic CNP level of the patients with the atrial fibrillation increases ,and the plasmic CNP level in the patients with permanent atrial fibrillation is higher than that in the patients with persistent and paroxysmal atrial fibrillation.%目的:探讨血浆C型利钠肽(CNP)水平变化与心房颤动不同类型的关系。方法将2012年10月至2013年10月该院门诊或住院治疗的心房颤动患者135例作为心房颤动组,其中永久性心房颤动组45例,持续性心房颤动组43例,阵发性心房颤动组47例;另选择健康体检者40例作为对照组。采用酶联免疫吸附试验方法检测血浆CNP水平,采用超声心动图测量心脏结构。结果各心房颤动组患者血浆CNP水平[

  1. Clinical Investigation.

    Science.gov (United States)

    1979-09-30

    Hiller, D.A., Elliott, J.P.: Tubal Ligation Syndrome Myth or Reality. Presented: Armed Forces Division of ACOG, New Orleans, Louisiana, October 1977...Molecular Weight Immunoreactive Glucagon Levels in Patients with the Post Prandial Syndrome . (Abst.) Western Society for Clinical Research, 1979. (3...Glucagon Levels in Patients witl the Post Prandial Syndrome . Presented: Western Society Meetings, Western Society for Clinical Research, February 1979. (3

  2. Clinical supervision.

    Science.gov (United States)

    Goorapah, D

    1997-05-01

    The introduction of clinical supervision to a wider sphere of nursing is being considered from a professional and organizational point of view. Positive views are being expressed about adopting this concept, although there are indications to suggest that there are also strong reservations. This paper examines the potential for its success amidst the scepticism that exists. One important question raised is whether clinical supervision will replace or run alongside other support systems.

  3. Clinical study on the relationship between myofascial pain syndromes and blood uric acid level%肌筋膜疼痛综合征与血尿酸水平的关系研究

    Institute of Scientific and Technical Information of China (English)

    李益军; 林杜峰; 李庐娟; 谢美玲; 郑彬; 方细霞

    2015-01-01

    Objective:To explore the relationship between myofascial pain syndromes(MPS)and blood uric acid(BUA)level.Meth-ods:Two hundred and nineteen patients with MPS were selected and divided into group A(aged 18 -29 years),group B(aged 30 -39 years),group C(aged 40 -49 years)and group D(≥50 years old).The BUA level,visual analogue score(VAS)and tenderness score of main pain sites were measured.Meanwhile the relationship between BUA level and age,pain degree and tenderness degree of main pain sites were analyzed.Results:The patients in group A(40 cases),B(84 cases)and C(57 cases)were males,while the patients in group D (38 cases)included 25 males and 13 females.There was no statistical difference in tenderness scores and VAS of main pain sites and BUA level between the 4 groups in males(1.30 +/-0.46,1.42 +/-0.54,1.39 +/-0.56,1.76 +/-0.66 points,χ2 =9.712,P =0.121;4.52 +/-1.41,4.48 +/-1.81,4.23 +/-1.71,5.20 +/-1.71 points,χ2 =5.940,P =0.115;500.35 +/-138.85.447.81 +/-130.97. 467.86 +/-123.70,455.32 +/-101.99 μmol/L,χ2 =4.152,P =0.246).A total of 138 hyperuricemia(HUA)out of 219 MPS were diag-nosed,including 126 males and 12 females,and 30 aged 18 -29 years,50 aged 30 -39 years,37 aged 40 -49 years and 21 ≥50 years old (9 males and 12 females).Males had high-to-low incidence rate of HUA in group A,C,B and D.The result of Pearson correlation analysis showed that BUA level were positively correlated with ages,tenderness scores and VAS of main pain sites in patients with MPS(r =0.425, P =0.016;r =0.496,P =0.004;r =0.402,P =0.028).Conclusion:The incidence rate of HUA is high in patients with MPS,and the BUA level is positively correlated with ages and the degree of pain and tenderness.%目的:探讨肌筋膜疼痛综合征(myofascial pain syndromes,MPS)与血尿酸水平的关系。方法:选取219例 MPS 患者,按照年龄分为18~29岁组、30~39岁组、40~49岁组和≥50岁组。测定患者的血尿酸水平、主要疼痛部位

  4. Relationship between autophagy of melanocytes in patients with vitiligo and clinical types%白癜风患者皮肤黑素细胞自噬与临床类型的相关性

    Institute of Scientific and Technical Information of China (English)

    聂慧琼; 王平; 张小燕; 丁承; 刘娇; 许爱娥

    2016-01-01

    Objective To evaluate autophagy of melanocytes and its mechanism in patients with vitiligo and to analyze its correlation with clinical types of vitiligo.Methods Nine cases of segmental vitiligo (SV) and 11 cases of generalized vitiligo (GV) were recruited in Hangzhou Third Hospital between May 2014 and June 2015.Six people with healthy skin were recruited as controls.Epidermal melanocytes were obtained from the normal colour skin around the white spot area in SV and GV patients and from foreskin in controls for culture in vitro.Cultures for each group contained negative control and rapamycin (30 nmol/L) sub-groups.The autophagy was observed using transmission electron microscopy (TEM) and immunofluorescence laser scanning confocal microscope (LSCFM).Protein expressions of microtubeassociated protein light chain 3 (LC3 Ⅱ) and microphthalmia-associated transcription factor (MITF),tyrosinase (TYR),tyrosinase related protein (TYRP) 1,and TYRP2 were detected by Western blot.Results (1) Autophagy of melanocytes was observed under TEM and LSCFM in both SV and control groups before rapamycin treatment,but not in GV patients.The expressions of autophagosome and LC3 Ⅱ protein were increased in melanocytes in SV,GV and control groups after autophagy induction (SV group 0.58 ± 0.10 vs 0.37 ±0.06;GV group 0.57 ±0.16 vs 0.22 ±0.08;control group 0.67 ±0.09 vs 0.46 ±0.12),and the autophagy intensity was higher in the GV group compared to the SV group and the control group.(2) Before autophagy induction,the expressions of MITF,TYR,TYRP1,and TYRP2 protein were lower in the GV and SV patients compared with the control group;after autophagy induction,the expressions of MITF,TYR,and TYRP1 statistically significantly increased in melanocytes in all the three groups (all P < 0.05),while TYRP2 protein expression was not significantly changed (all P > 0.05).Conclusions Autophagy of melanocytes may be present in vitiligo and affect the expression of functional molecules

  5. Relationship between the Clinical Effect and TCM Syndrome for Treatment of Lumbar Disc Hernination with Dragon Seven%盘龙七片治疗腰椎间盘突出症临床疗效与中医证候关系的临床观察

    Institute of Scientific and Technical Information of China (English)

    陈镜锋; 余庆阳; 李杰; 吕超锋

    2012-01-01

    Objective:To observe the relationship between the clinical effect and TCM syndrome for treatment of lumbar disc hernination with dragon seven. Methods: All 120 cases with lumbar disc hernination were randomly divided into blood stasis group, cold card group, damp heat group, and liver and kidney deficiency group according to TCM syndromes, with 30 cases in each group. They were all oral treated with dragon seven, and then, the relationship between the clinical effect and TCM syndrome was analyzed. Results:The clinical efficacy was significantly different before and after treatment with dragon seven in the blood stasis group and cold card group, but which was no different in the damp heat group and liver and kidney deficiency group. Conclusion: The dragon seven are effective for treatment of lumbar disc hernination with TCM syndromes of blood stasis and cold card. Clinicians applied of proprietary Chinese medicines should according to TCM syndromes.%目的:观察盘龙七片治疗腰椎间盘突出症临床疗效与中医证候关系.方法:通过盘龙七片治疗腰椎间盘突出症120例,按中医证候分型分为血瘀证、寒湿证、湿热证、肝肾亏虚证四种证型各30例,均采用盘龙七片口服治疗,治疗后根据其疗效评定分析盘龙七片治疗腰椎间盘突出症临床疗效与其中医证型的关系.结果:盘龙七片治疗腰椎间盘突出证属血瘀证与寒湿证两种中医证型临床疗效治疗前后有明显的差异性,而湿热瘀阻、肝肾亏虚治疗前后临床疗效比较没有明显的差异性.结论:盘龙七片治疗血瘀证、寒湿证腰椎间盘突出症具有明显有临床疗效,临床医生在临床上应用中成药时要根据中医辨证论活选择使用中成药.

  6. A clinical study on relationship of dental caries and removable partial denture of the aged patients%老年患者基牙龋病与可摘局部义齿关系的临床研究

    Institute of Scientific and Technical Information of China (English)

    李行懿; 陈娜; 刘聪

    2011-01-01

    Objective To characterize (patterns of caries after placing RPD. Methods A total of 95 patients were included in this study. A clinical examination of caries lesions on abutment teeth was conducted by me. Results The incidence of caries on abutment teeth and on nonabutment teeth were respectively 23. 67% and 3. 45%. ( P < 0.05). 27.49% of abutment teeth had new caries on the posterior oral cavity, onlyl3.89% of that on the anterior oral cavity. (P<0. 05). The incidence of caries on proximal surfaces adjacent to dentures was 25. 72% , under denture rests was 9. 33% , on root surfaces was 3. 02% , on tooth surfaces in contact with denture clasps was 1. 36% . The incidence of caries on abutment teeth of three groups classified by the oral hygienic habit were respectively 8. 91% 、24. 09%、44. 29% (P<0.01). Conclusion RPD wearers had more caries incidence. Abutment teeth had a higher of incidence of caries than nonabutment teeth. On the posterior oral cavity, abutment teeth had more caries incidence. Proximal surfaces adjacent to dentures abutment teeth had more caries incidence. Proximal surfaces adjacent to dentures were at highest risk of being decayed, surfaces under denture rests were next. The incidence of root caries on abutment teeth significantly increased. The incidence of caries on tooth surfaces in contact with denture clasps was not high.%目的 观察老年患者戴用可摘局部义齿2-3年后的龋病发病情况及其临床特点.方法 对95例戴用可摘局部义齿2-3年患者的基牙和非基牙的龋齿发病情况进行检查.结果 基牙龋齿发病率23.67%高于非基牙3.45%(P<0.05).口腔后部基牙龋齿发病率27.49%高于口腔前部基牙13.89%(P<0.05).基牙邻接面龋发病率25.72%,支托窝龋发病率9.33%,根面龋发病率3.02%,卡环龋发病率1.36%.口腔卫生习惯优、良、差三级的基牙龋齿发病率分别为8.91%、24.09%、44.29%,差异有显著性(P<0.01).结论 患者戴用可摘局部义齿后易患龋

  7. Relação entre acuidade visual e atividades instrumentais de vida diária em idosos em seguimento ambulatorial Relationship between visual acuity and instrumental activities of daily living of the elderly in clinical segment

    Directory of Open Access Journals (Sweden)

    Sheila de Melo Borges

    2010-06-01

    Full Text Available OBJETIVO: Avaliar a influêrcia da acuidade visual nas atividades instrumentais de vida diária em idosos em seguimento ambulatorial. MÉTODOS: Foram entrevistados, por meio de instrumento próprio, 64 idosos em seguimento ambulatorial num hospital universitário de Campinas/SP. Os sujeitos foram divididos em dois grupos, conforme os valores obtidos na medida da AV: o grupo I, composto pelos idosos com visão normal ou próxima do normal; e o grupo II, formado por aqueles com baixa visão. Foram realizadas correlações bivariadas entre as variáveis, a fim de identificar as seguintes relações entre os grupos de acuidade visual e as atividades instrumentais de vida diária. RESULTADOS: Foram observadas diferenças significativas entre os idosos com visão normal ou próxima do normal (grupo I e aqueles com baixa visão (grupo II, com respeito às variáveis. O grupo II apresentou maior dificuldade do que o grupo I no escore total do instrumento, bem como nas seguintes tarefas: uso do telefone, preparo de refeições, trabalhos manuais, lavar e passar roupa e tomar corretamente os remédios. CONCLUSÃO: Neste estudo, idosos com baixa visão de ambos os sexos apresentam maior dificuldade para realizar as AIVDs do que idosos com visão normal ou próxima do normal.OBJECTIVE: To evaluate the influence of visual acuity in instrumental activities of daily living in elderly patients in follow-up period. METHODS: through own instruments, sixty-four elderly men and women were interviewed in clinical segment at an academic hospital of Campinas/SP. They were then divided into two groups in accordance to the values that were obtained through the measure of the VA: the first group consisted of elderly people with normal vision or close to the normal, and the second group was formed of those with low vision. Bivariate correlations were made between the variables in order to identify the following relations: between groups of visual and instrumental

  8. Relationship and Clinical Significance between Soluble CD146 and Chronic Kidney Disease%sCD146与慢性肾脏病的关系及其临床意义的研究

    Institute of Scientific and Technical Information of China (English)

    蒋宏伟; 洪明玉; 汪年松; 周毅; 严春华

    2011-01-01

    目的:探讨外周血sCD146水平在慢性肾脏病(CKD)中的意义及其与肾功能其他相关指标的关系.方法:入选101例CKD患者,CKD1期28例,CKD2期25例,CKD3期16例,CKD4期14例,CKD5期18例,(无血透患者).设健康对照组20例.采用ELISA法检测sCD146水平.分析sCD146在CKD各期中的变化及其与肾功能相关指标的关系.结果:各组CKD患者sCD146水平,均显著高于对照组(196.22±30.83)ng/ml.sCD146水平随着CKD1~5期进展升高,P<0.05.相关分析显示sCD146与Scr、BUN、β2-MG、CysC水平呈正相关(r分别为:0.676,0.680,0.685,0.604),与eGFR、Hb呈负相关(r分别为:-0.802,-0.586).多因素逐步回归分析显示eGFR、Scr是影响sCD146的独立因素.结论:sCD146与CKD肾脏血管内皮损伤密切相关;sCD146较好地反映了CKD患者肾功能的进展及严重程度;sCD146能在一定程度上反映肾脏内皮细胞的早期损伤情况,其能否作为检测CKD患者肾功能损伤新的内源性标志物,有待进一步研究.%Objective: To detect the level of soluble CD146( sCD146 )and explore its relationship with chronic kidney disease ( CKD ). Methods: Methods: A total of 101 patients with CKD, including 28 cases of CKD1,26 cases of CKD2,16 cases of CKD3 ,14 cases of CKD4,18 cases of CKD5( none case of hemodialysis ). 20 healthy volunteers were enrolled as control. Serum levels of sCD146 were measured by ELISA. Results: The serum levels of sCD146 in each CKD group are [ CKD1( 218. 46 ± 34. 31 )ng/ml, CKD2 ( 245. 94 ±21. 82 )ng/ml,CKD3( 273. 99 ±21. 87 )ng/ml,CKD4( 295.55 ±21.79 )ng/ml,CKD5( 326. 55 ±26. 75 )ng/ml ],which is significantly higher than those in control group ( 196. 22 ± 30. 83 )ng/ml. sCD146 levels were gradually increased according to the different stages of CKD ( P <0. 05 ), meanwhile sCD146 level was positively correlated with Scr,BUN, β2 microglobulin andCystainC( r = 0. 676,0. 680,0. 685 ,0. 604, respectively ), andnegatively correlated with eGFR and hemoglobin( r

  9. 高血压中医证型与血脂、血尿酸关系研究%Clinical research on the relationship of TCM Syndrome type and blood lipids, blood uric acid

    Institute of Scientific and Technical Information of China (English)

    罗芳

    2011-01-01

    Objective To study the relationship between blood lipids, blood uric acid and hypertension.Methods 118 patients with hypertension, the TCM Syndrome type were collected. 20 cases over the same period were selected as the healthy control group. The total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides ( TG ), serum uric acid (SUA) were detected. Blood lipids, blood uric acid levels and abnormal rate in various syndromes of hypertension group and control group were compared.Results Of hypertension and high blood pressure phlegm dampness Yinxuyangkang card lipids, SUA exception caught was higher(P < 0.05) lower blood pressure and SUA abnormal deficiency of both yin and yang( P < 0.05 ). Yin card,phlegm dampness card ,anger Kang Sheng card TC higher(P <0.01 ) ;phlegm dampness syndromes TG than hyperactivity syndrome(P <0.05) ;high deficiency of both yin and yang type of blood pressure,HDL-C lower than the control group and other syndromes of hypertension(P <0.05 or <0.01 ) deficiency of both yin and yang type of high blood pressure higher than other groups SUA and other syndromes of hypertension the control group ( P < 0. 01 ).Conclusion In patients with hypertension,the elevated TG was corralated with the phlegm dampness,and the phlegm dampness could be used as evidence of high blood pressure reference. HDL-C decreased,SUA increased with the yin and yang,and it could be used as the reference to deficiency of both yin and yang.%目的 探讨高血压中医证型与血脂、血尿酸关系。方法 收集高血压患者118例,进行中医辨证分型。另选同期健康体检者20例作对照组。检测两组总胆固醇(TC)、低密度脂蛋白胆固醇( LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、血尿酸(SUA)。比较高血压各证型组及对照组血脂、血尿酸水平及异常率。结果 高血压阴虚阳亢证和高血压痰湿壅盛证血脂

  10. Relationship between prostate specific antigen related variables and Gleason score and clinical stage of prostate cancer%前列腺特异性抗原相关变数与前列腺癌Gleason评分及临床分期的关系

    Institute of Scientific and Technical Information of China (English)

    王道元; 乔保平; 孙如坤; 辛航; 王雷阳

    2012-01-01

    目的:探讨前列腺特异性抗原(PSA)相关变数与前列腺癌病理分级及临床分期的关系.方法:回顾性分析125例经穿刺活检病理证实为前列腺癌患者的临床资料,采用Spearman相关分析探讨游离PSA(FPSA)、FPSA比率(F/TPSA)、PSA密度(PSAD)与Gleason评分及临床分期的关系.结果:FPSA与前列腺癌Gleason评分呈正相关(rS=0.499,P<0.001),与临床分期呈负相关(rS=-0.300,P<0.001);PSAD与前列腺癌Gleason评分呈正相关(rS=0.616,P<0.001),与临床分期无相关性(rS=-0.128,P=0.155);F/TPSA与前列腺癌Gleason评分呈弱相关(rS=0.182,P=0.042),与临床分期呈负相关(rS=-0.417,P<0.001).结论:FPSA可作为前列腺癌病理分级和临床分期的参考指标;而PSAD可作为前列腺癌病理分级的参考指标,F/TPSA可作为前列腺癌临床分期的参考指标.%Aim : To explore the relationship between prostate specific antigen related variables and Gleason score and clinical stage in patients with prostate cancer. Methods: The clinical data from 125 cases of prostate cancer diagnosed by biopsies were collected, and the correlation of FPSA , F/TPSA and PSAD with Gleason score and clinical stage was analyzed. Results: FPSA was positively correlated with Gleason score ( rs =0. 499 , P < 0. 001 ) , but negatively correlated with clinical stage ( rs = - 0. 300 , P < 0. 001) for prostate cancer patients ; PSAD was also positively correlated with Gleason score ( rs = 0. 616 ,P < 0. 001 ) , but not correlated with clinical stage ( rs = - 0. 128 ,P = 0. 155 ) for prostate cancer patients; F/TPSA was negatively correlated with clinical stage ( rs = -0.417,P<0. 001 ) , but weakly correlated with Gleason score ( rs = 0. 182 ,P = 0. 042) for prostate cancer patients. Conclusion ;FPSA could be used as a reference index in pathological grading and clinical staging for prostate cancer patients ; PSAD could be used as a reference index in pathological grading and F/TPSA could be used as a reference

  11. 78 FR 55728 - Society of Clinical Research Associates-Food and Drug Administration: Food and Drug...

    Science.gov (United States)

    2013-09-11

    ... interaction with FDA representatives. The program will focus on the relationships among FDA and clinical trial... Expects in a Pharmaceutical Clinical Trial; (4) Medical Device Aspects of Clinical Research; (5)...

  12. Customer relationship marketing

    OpenAIRE

    Sæter, Jan Øyvind

    2006-01-01

    Customer relationship marketing has become an interesting choice of strategy for companies in today’s competitive markets. Different positioning strategies like price and product quality are easy to imitate, eluding the importance of sustainable competitive advantage. The customers need to be attracted and bonded towards the store through relationships. The paper discusses several factors affecting relationship marketing and the advantages with this strategy. Through the the...

  13. Relationship between pelvic lymph node metastasis and clinical pathological characteristics of cervical cancer%NT-proBNP 对2型糖尿病患者心率变异性的影响

    Institute of Scientific and Technical Information of China (English)

    张冬梅; 张军; 张亚平; 李伟

    2016-01-01

    analysis.Blood was collected from patients with venous blood, centrifuge analysis of its serum, speed of 3000 r/min, after ten minutes of centrifugal, using the NT-proBNP AQT90 of the company’s production of FLEX. Results The differences of NT-proBNP and HRV levels in the two groups were statistically significant; the time domain analysis index of the two groups were significantly different (DANN), HF, RMSSD, PNN50, VLF, LF and SDNN, LF and VLF. No significant correlation was found between SDNN, PNN50 and HF. Conclusion The level of NT-proBNP in patients with type 2 diabetes associated with HRV, can damage cardiac function of autonomic nervous response in patients with type 2 diabetes in clinic, NT-proBNP can be used as a reference for the diagnosis of type 2 diabetes.

  14. Governing IT outsourcing relationships

    CERN Document Server

    Kuhlmann, Daniel

    2012-01-01

    Hauptbeschreibung The dynamics of the relationship between service recipient and service provider in IS outsourcing relationships recently gained increased attention as relationships are believed to have a considerable influence on IS outsourcing success. This study adds to this growing field of interest by developing an IS outsourcing relationship framework in the form of a process model. Three rather disjointed areas of research, namely contractual governance, relational norms, and control, have been set in a common context by interrelating them as the three main governance modes

  15. 广东潮州地区强直性脊柱炎患者 HLA-B27的检测与临床相关性研究%Investigation of the relationship between clinical manifestation of ankylosing spondylitis and HLA-B27 antigen in Chaozhou, Guangdong Province

    Institute of Scientific and Technical Information of China (English)

    刘潮坚; 蔡拉加; 石昭宏; 林剑雄

    2013-01-01

      目的检测强直性脊柱炎(Ankylosing spondylitis,AS)患者 HLA-B27抗原表达情况,并分析其与临床情况的关系.方法选择我院2008年5月到2011年5月期间150例 AS 患者,按 HLA-B27抗原表达分为两组:HLA-B27阳性组(n=108)及 HLA-B27阴性组(n=42).分别检测两组血标本血沉、C 反应蛋白、α1-酸性糖蛋白水平,并检查心电图、骨盆正位片和腰椎正侧位,比较两组的发病年龄、性别比、临床症状.结果① HLA-B27阴性组以31~45岁年龄段为主(占阴性组52.4%),阳性组以16~30岁年龄段为主(占阳性组57.4%);② HLA-B27阳性组较阴性组全身症状更为严重(P0.05);③ HLA-B27阴性组较多表现为在窦缓和/或传导阻滞,而 HLA-B27阳性组则较多表现为左室高电压(P0.05).结论 AS 患者临床症状与 HLA-B27抗原有很高的相关性,HLA-B27抗原阴性患者与阳性患者相比病情较轻,预后较好.%Objective To investigate the relationships between clinical manifestation of ankylosing spondylitis (AS) and HLA-B27 antigen by analyzing the expression level of HLA-B27 antigen. Methods During May 2008 and May 2011, 150 AS patients attended our study. According to the expression level of HLA-B27 antigen, these patients were classified into two groups: HLA-B27 negative group and HLA-B27 positive group. The erythrocyte sedimentation rate (ESR), CRP, and α1-AGP, electrocardiogram, anterioposterior radiograph of pelvis, anterior and lateral lumbar vertebral X ray were also examined. The age of onset, sex proportion, and clinical manifestation were compared in the two groups. Results ① HLA-B27 negative expression mainly ranged from 31 to 45 years old (52.4%), but positive expression group mainly ranged from 16 to 30 years old (57.4%). ② The rate of systemic symptom such as fever, night sweat, and fatigue were higher in HLA-B27 positive group than that in negative group(P0.05). ③ The major clinical symptom in HLA-B27 negative patients were sinus

  16. Enhancing Adult Learning in Clinical Supervision

    Science.gov (United States)

    Goldman, Stuart

    2011-01-01

    Objective/Background: For decades, across almost every training site, clinical supervision has been considered "central to the development of skills" in psychiatry. The crucial supervisor/supervisee relationship has been described extensively in the literature, most often framed as a clinical apprenticeship of the novice to the master craftsman.…

  17. Using Clinical Cases to Teach General Chemistry

    Science.gov (United States)

    Dewprashad, Brahmadeo; Kosky, Charles; Vaz, Geraldine S.; Martin, Charlotte L.

    2004-01-01

    A clinical study was designed and used to show the relationship of health and medicine, in a typical clinical scenario, where many chemical principles are involved and that an integrated knowledge of chemistry and biology is essential to the understanding, diagnosing and treating of illnesses. A case study would be a positive learning experience…

  18. Gait in ageing and associated dementias; its relationship with cognition

    NARCIS (Netherlands)

    Scherder, Erik; Eggermont, Laura; Swaab, Dick; van Heuvelen, Marieke; Kamsma, Yvo; de Greef, Mathieu; van Wijck, Ruud; Mulder, Theo

    2007-01-01

    The focus of this review is on the close relationship between gait and cognition in ageing and associated dementias. This close relationship is supported by epidemiological studies, clinical studies of older people with and without dementia that focused on the intensity of the physical activity, cli

  19. Gait in ageing and associated dementias; its relationship with cognition

    NARCIS (Netherlands)

    Scherder, E.; Eggermont, L.; Swaab, D.F.; Heuvelen, M. van; Kamsma, Y.; Greef, M. de; Wijck, R. van; Mulder, T.

    2006-01-01

    The focus of this review is on the close relationship between gait and cognition in ageing and associated dementias. This close relationship is supported by epidemiological studies, clinical studies of older people with and without dementia that focused on the intensity of the physical activity, cli

  20. Mismatched: ADHD Symptomatology and the Teacher-Student Relationship

    Science.gov (United States)

    Rogers, Maria; Bélanger-Lejars, Véronique; Toste, Jessica R.; Heath, Nancy L.

    2015-01-01

    The goal of this study was to investigate the relationship between children with attention-deficit/hyperactivity disorder (ADHD) symptoms and their teachers, and to examine whether this relationship was associated with children's academic motivation. The sample comprised 35 children with clinically elevated levels of ADHD symptoms and 36 children…

  1. 农村某基层医院护士工作压力与社会支持的相关性研究%The relationship between working pressure and social support among clinical nurses of grass-roots hospitals in Shantou rural area

    Institute of Scientific and Technical Information of China (English)

    徐友芳; 万君; 马燕君

    2013-01-01

    Objectives: To investigate working pressure and social support among clinical nurses of grass-roots hospital in Shantou, to explore the relationship between the two variables, and to provide references for managers to take targeted measures. Methods: We investigated 288 clinical nurses of grass-roots hospitals in Shantou rural area by questionnaires. Results: The mean score of working pressure was 2.81± 0.43 and in a moderate to high level. The main pressure sources were low salary and other benefits and high work-load. Working pressure negatively related to social support. Objective support was the main influencing factor of working pressure. Conclusions: Managers should pay more attention to the negative impact of the high work-load among clinical nurses in grass-roots hospitals in rural area, provide substantial and emotional support to nurses, and reduce working pressure to stabilize the nursing team, to improve clinical nurses' physical and psychological health, and to enhence working efficiency and nursing quality in grass-roots hospitals.%目的:调查基层医院临床护士工作压力及社会支持情况,并探讨两者的相关性,为管理者制订针对性的干预措施提供依据.方法:采用问卷调查法,以汕头农村地区某基层医院的288名在岗临床护士作为对象进行调查.结果:临床护士的工作压力总均分为(2.81±0.43)分,呈中等偏高水平;最大的压力源是工资及其他的福利待遇低,其次是工作量太大;工作压力与社会支持水平呈负相关;客观支持是护士工作压力的影响因素.结论:管理者应重视农村地区基层医院临床护士工作压力过高带来的负面影响,在物质和情感等方面提供支持,降低其工作压力,为稳定护理队伍,提高基层医院临床护士身心健康水平、工作效率及护理质量起到积极的促进作用.

  2. Clinical Trials

    Science.gov (United States)

    ... and her initial results. Nueva Esperanza Para Las Enfermedades Del Corazón 09/23/2014 Milena tuvo un ... Story 09/23/2014 Nueva Esperanza Para Las Enfermedades Del Corazón 09/23/2014 Children and Clinical ...

  3. Organizational Relationship Termination Competence

    DEFF Research Database (Denmark)

    Ritter, Thomas; Geersbro, Jens

    2011-01-01

    that a firm's percentage of unwanted customers decreases significantly as acceptance of termination increases, if the firm's definition of unwanted customers is well understood, and if a firm has clear termination routines. In addition, general focus on profitability and external constraints on relationship...... termination are found to significantly affect a firm's relationship termination competence. The findings suggest that managers should regard termination as a legitimate option in customer relationship management. In order to decrease the number of unwanted customers, managers must accept termination......Most firms are involved in a number of customer relationships that drain the firm's resources. However, many firms are hesitant to address this problem. This paper investigates customer relationship termination at the organizational level. We develop and analyze the organizational dimensions...

  4. Jealousy and Relationship Closeness

    Directory of Open Access Journals (Sweden)

    Mark Attridge

    2013-02-01

    Full Text Available This study confirmed a hypothesis from the Emotion-in-Relationships conceptual model, which predicts that greater interdependence between relationship partners—or closeness—creates the potential for jealousy. The study also sought to better define the positive side of romantic jealousy in addition to its more negative attributes. College students in premarital relationships (N = 229 completed a questionnaire, including 27 different measures and the Multidimensional Jealousy Scale. Select data were obtained from 122 cases at 3-month follow-up. Each jealousy scale was tested for associations with demographic (age, sex, and race, person (life satisfaction, loneliness, romantic attachment styles, love styles, and romantic beliefs, and relationship (affective, closeness, and social exchange theory constructs. Results clearly distinguished emotional/reactive jealousy as mostly “good” and cognitive/suspicious jealousy as “bad.” Behavioral jealousy was associated with few measures. Implications are discussed for the interdependence model of relationships and the transactional model of jealousy.

  5. The study for Salmonella resistant and the analysis of enterotoxin gene and clinical relationship in children with diarrhea%腹泻儿童沙门菌的耐药性研究及肠毒素基因与临床关系分析

    Institute of Scientific and Technical Information of China (English)

    陈庆法; 陈强; 余晓君; 周红平; 柯江维; 朱春晖; 段荣

    2011-01-01

    Objective To investigate the clinical features , the drug resistance and the clinical relationship of toxin and clinical features , provide the basis for judgement and treatment of clinical conditions. Methods 80 strains of Salmonella were isolated from the stool of children with diarrhea in our hospital from April 2004 to December 2009,identified Salmonella serotypes by serum agglutination test ,then antimicrobial drug susceptibility was detected by Kerby -Bauer disc diffusion method. At the same time, the enterotoxin gene (spvA,spvB,rck) was detected by PCR, the relationship of clinical features and the toxin in children with Salmonella enteritis was analysed. Results Fever and diarrhea were the major clinical manifestations of disease-oriented. Salmonella typhimurium were the major serotypes of children with Salmonella enteritis (70/80, 87. 5 % ). 80 strains of Salmonella were all sensitive to Imipenem and Meropenem ,but different levels of resistance to other antibiotics . 66 strains of Salmonella were multiple drugresistant strains, 17 strains were suspicious producing ESBLs , 8 strains were suspicious producing AMPC enzyme, Salmonella typhimurium were significantly higher than other Salmonella in multidrug resistance ( x2= 30. 921 ,P = 0. 001 ). All Salmonella genes contained spvA , a small number of Salmonella genes contained spvB and rck ,the ratio of high fever in children was higher in spvB positive strains than spvB negative strains (X2 =7. 544 ,P =0. 006) ,the ratio of bloody mucus in children was higher in spvB positive strains than spvB negative strains (x =6. 163 ,P =0.013). Conclusions Salmonella typhimurium are major pathogens of children with Salmonella enteritis. Fever and diarrhea are the major clinical manifestations . Salmonella typhimurium are significantly higher than other Salmonella in multidrug resistance ,the spvB positive strains have more clinical manifestations of hight fever and mucosanguineousfeces . Rational use of antibiotics

  6. 77 FR 49449 - Food and Drug Administration Clinical Trial Requirements, Compliance, and Good Clinical Practice...

    Science.gov (United States)

    2012-08-16

    ... to facilitate interaction with FDA representatives. The program will focus on the relationships among.... Topics for discussion include the following: (1) What FDA Expects in a Pharmaceutical Clinical Trial;...

  7. Relationship between neuropsychological and clinical aspects and suicide attempts in euthymic bipolar patients Relação entre aspectos clínicos e neuropsicológicos e as tentativas de suicídio em pacientes eutímicos com transtorno afetivo bipolar

    Directory of Open Access Journals (Sweden)

    Paulo Henrique Paiva de Moraes

    2013-01-01

    Full Text Available Some studies have investigated the possible relationship between suicide attempts and impulsivity in patients with bipolar disorder. The objective of this study was to assess the relationship between neuro-psychological and clinical aspects and suicide behavior in euthymic bipolar patients. The Iowa Gambling Task and the Conner's Continuous Performance Test evaluated impulsivity in 95 euthymic bipolar patients - 42 suicide attempters and 115 normal control participants. A factorial analysis evaluated the adequacy of the instruments. Furthermore, a multiple regression analysis was done in order to develop a model to predict suicide attempts. Our results point to a specific type of impulsivity related to making decisions, lack of planning and borderline personality disorder comorbidity. This type of impulsivity is a risk factor for suicide attempts in patients with bipolar disorder.Alguns estudos investigaram a possível relação entre tentativas de suicídio e impulsividade em pacientes com transtorno bipolar. O objetivo do estudo foi avaliar a relação entre características neuropsicológicas e clínicas e o comportamento suicida em pacientes bipolares eutímicos. Utilizamos o Iowa Gambling Task e o Conner's Continuous Performance Test para avaliar a impulsividade em 95 pacientes eutímicos com transtorno bipolar (42 com tentativas de suicídio e 155 controles normais. Uma análise fatorial avaliou a adequação dos instrumentos e foi criado um modelo para previsão do número de tentativas de suicídio usando regressão linear múltipla. Nossos resultados apontam para um tipo específico de impulsividade relacionada à tomada de decisões, falta de planejamento e para a comorbidade Transtorno de Personalidade Borderline. A impulsividade por não planejamento é um fator de risco para tentativas de suicídio em pacientes com Transtorno Bipolar.

  8. The Relationship of hURAT1,SLC2A9 and ABCG2 with Hyperuricemia and Gout and the Clinical Significance%hURAT1、SLC2A9、ABCG2与高尿酸血症、痛风的关系及临床意义

    Institute of Scientific and Technical Information of China (English)

    张蓓

    2013-01-01

    Hyperuricemia and gout incidence are increased steadily year by year and they have strong relationship with renal and cerebrovascular system diseases,which are drawing wide attention gradually. Recent studies have shown that genovariation of hURAT1, SLC2A9 and ABCG2 are highly correlated with hyperuricemia and gout,playing very important roles in the pathogenesis of the diseasess. Here is to make a review on the relationship between the susceptible genes and hyperuricemia and gout,and their clinical significance.%高尿酸血症和痛风与肾脏和心脑血管系统疾病的发生、发展关系密切,近年来发病率呈逐年升高趋势,逐渐引起人们的广泛重视.最近研究发现人尿酸盐转运蛋白1(hURAT1)、尿酸转运子SLC2A9和ABC转运蛋白2 (ABCG2)三个尿酸盐转运蛋白的基因变异与高尿酸血症和痛风的发生呈高度相关,在疾病发病机制中起到重要的作用.现就hURAT1、SLC2A9和ABCG2与高尿酸血症、痛风的关系及其临床意义进行综述.

  9. Educational climate seems unrelated to leadership skills of clinical consultants responsible of postgraduate medical education in clinical departments

    DEFF Research Database (Denmark)

    Malling, Bente Vigh; Mortensen, Lene Sundahl; Scherpbier, Albert J J;

    2010-01-01

    The educational climate is crucial in postgraduate medical education. Although leaders are in the position to influence the educational climate, the relationship between leadership skills and educational climate is unknown. This study investigates the relationship between the educational climate...... in clinical departments and the leadership skills of clinical consultants responsible for education....

  10. 脑瘫足内、外翻的发生与脑瘫临床类型关系的探讨%A Study on the Relationship Between the Clinical Types of the Foot Inner and Outer of Cerebral Palsy and Cerebral Palsy

    Institute of Scientific and Technical Information of China (English)

    张涛

    2016-01-01

    目的:探讨脑瘫足内、外翻的发生与脑瘫临床类型的关系。方法选取2011年2月~2014年2月我科收治的脑瘫患儿510例,设计调查表,统计各临床类型脑瘫足内、外翻发生情况,找出发生规律。结果痉挛型脑瘫足内、外翻发生率分别为76.7%和68.0%,共济失调型和肌张力低下型脑瘫足外翻发生率分别为40.0%和50.0%。结论共济失调型和肌张力低下型脑瘫足外翻发生率最高,而痉挛型脑瘫足内、外翻发生率均偏高。%Objective To study the relationship between the clinical types of cerebral palsy foot inner and outer relationship and cerebral palsy.Methods From February 2011 to February 2014, 510 cases of children with cerebral palsy at our department were selected, to design the questionnaire, to count up the occurrence of the situation about the clinical types of cerebral palsy in the foot inner and outer and to ifnd out the occurrence of the law.Results The incidence rate of the inner and outer foot of spasm cerebral palsy were 76.7% and 68.0% respectively, The incidence rates of ataxia type and the outer foot of hypotonic cerebral palsy were 40.0% and 50.0% respectively. Conclusion The incidence rate of ataxia and the outer foot of hypotonic cerebral palsy was highest, the incidence rate of the inner and outer foot of spasm cerebral palsy is on the high side.

  11. The relationship between depression and erectile dysfunction.

    Science.gov (United States)

    Seidman, S N; Roose, S P

    2000-06-01

    Normal sexual function is a biopsychosocial process; sexual dysfunction almost always has organic and psychologic components, and it requires multidisciplinary, goal-directed evaluation and treatment. Factors such as aging, declining testosterone levels, medical illness, certain medications, and comorbid depressive illness can contribute to sexual dysfunction. Erectile dysfunction (ED) is the most common male sexual dysfunction encountered in the clinical setting. Comorbidity between ED and depressive illness is high, but the causal relationship is unclear, and likely bidirectional. In this article, we review the existing literature on the relationship between depression and ED.

  12. 某市临床护士健康相关生命质量及其与应激源关系的探讨%Study on relationships between health-related quality of life and its stress source for clinical nurses in Lu'an city

    Institute of Scientific and Technical Information of China (English)

    朱文娟; 胡传来; 沈国文

    2013-01-01

    Objective To investigate the relationships between health - related quality of life and its stress sources for clinical nurses. Methods All 500 clinical nurses from two hospitals in Luan city were recruited in this study. Questionnaire of sociodemographic characteristics , stressor scale of nurse work, scales of family functioning ( APGAR ) and social support, health - related quality of life ( SF - 36 ) were selected for quantitative measurement. Statistics was showed with mean ± SD. Regression and multivariate logistic regression statistical analysis was applied to explore the health risks. Results Health - related quality of life scores were lower in nurses than the national popunl-atin norm, and all of the eight dimensions had obvious correlation with the source of stress. With the regression analysis, stressors of interpersonal communication in the relationship between the pressure of the nurses'psychosocial stressors, learning and promotion pressure had a significant impact on the health - related quality of life in clinical nurses. Source of stress in daily life and work, family functioning, social support could significantly affect the health -related quality of life. Conclusion It is suggested that intervention in family functioning, working conditions, and increasing social support actions should improve the health - related quality of life for clinical nurses.%目的 调查某市临床护士健康相关生命质量及其与应激源的关系.方法 对某市500名临床护士应用一般情况调查表、护士工作压力源量表、家庭功能量表、社会支持量表及生命质量评价量表进行问卷调查,并对结果进行分析.结果 护士生命质量的各个维度得分均低于常模分值,8个维度均与应激源有明显的相关性.通过回归分析可见人际沟通应激源中护士与护士关系压力,社会心理应激源中学习与晋升压力对护士生命质量的影响具有统计学意义.日常生活和工作中的

  13. [The relationship between whiplash injury and temporomandibular joint dysfunction].

    Science.gov (United States)

    Barak, Shlomo

    2013-10-01

    This article aims to discuss the possible relationship between rapid extension-flexion of the neck-whiplash injury and temporomandibular disorders (TMD). Clinical experience and studies revealed that whiplash injury may cause TMD. The pathophysiology of TMD is described as well as clinical and imaging diagnostic criteria. The treatment modalities for TMD are: physiotherapy, nonsteroidal anti-inflammatory drugs and occlusal splints.

  14. Ethical Issues in Mentoring Doctoral Students in Clinical Psychology

    Science.gov (United States)

    Rosenberg, Anna; Heimberg, Richard G.

    2009-01-01

    Ethical issues abound in any relationship that is defined by differences between the parties in rank, status, and power. Such is the case in the relationship between a doctoral student in clinical psychology and his or her mentor. In this article, we examine several potential areas of ethical concern within the mentor-student relationship. We…

  15. Study on the clinical symptoms of schizophrenia patients accompanied by obsessive-compulsive symptoms and its relationship with their quality of life%伴强迫症状精神分裂症患者的临床症状与生活质量相关性研究

    Institute of Scientific and Technical Information of China (English)

    蔡洪斌; 崔明湖

    2015-01-01

    目的:探讨伴强迫症状精神分裂症患者的临床症状与生活质量相关性。方法:收治伴有强迫症状精神分裂症患者32例(伴强迫症状精神分裂症组),并随机抽取没有强迫症状精神分裂症患者32例(精神分裂症组)作对照。结果:两组患者PANSS阳性量表分与生活质量存在显著负相关。结论:伴强迫症状精神分裂症患者的临床症状与生活质量存在相关性。%Objective:To investigate the clinical symptoms of schizophrenia patients accompanied by obsessive-compulsive symptoms and its relationship with their quality of life.Methods:32 schizophrenia patients accompanied by obsessive-compulsive symptoms(as the schizophrenia with obsessive-compulsive symptoms group)were selected,and 32 schizophrenic patients without obsessive-compulsive symptoms were randomly selected as the control group(schizophrenia group).Results:The PANSS positive score had significantly negative correlation with patients life quality in two groups.Conclusion:The clinical symptoms of schizophrenia patients accompanied by obsessive-compulsive symptoms has correlation with patients life quality.

  16. Close partner relationships

    Directory of Open Access Journals (Sweden)

    Stefanović-Stanojević Tatjana Z.

    2002-01-01

    Full Text Available According to the theory of emotional attachment, specific emotional relationships are being established at an early age between a child and its parents. On the basis of the quality of these relationships the child creates the so-called internal working model ie the image of itself as well as others. The working model persists throughout one's lifetime, shaping in part the quality of adult relationships. Thus, a dominant adult relationship is a close, partner or love one. Within the indicated theoretical context, we were interested in finding out whether there is a statistically significant link between the emotional ties of parents and their children formed in early childhood. The investigation included 180 grown-ups of the same sex and age. For investigating close partner relationships the test Experience in Close Relationship by the American authors (Brenan K.A., Clark C.L., & Shaver P.R. 1998. was used, while the early emotional relationships were investigated using a test which has been the only one so far to measure this quality in adults - Adult Attachment Interview, (Main M., Casidy J., & Kaplan N., 1985. The results show there is a statistically significant link between the observed variables.

  17. Coaching relationship - and beyond

    DEFF Research Database (Denmark)

    Spaten, Ole Michael; O'Broin, Alanna; Løkken, Lillith Olesen

    2016-01-01

    In the coaching context of an ongoing search for evidence-based research, and increasing interest in the ‘active ingredients’ of coaching the impetus for ‘the coaching relationship – and beyond’ was the quest for deeper understanding of the coaching relationship as well as its influence on the ou...... measures from the existing coachées’ satisfaction evaluation metrics; and finally (d) an overview of coaching relationship research in the context of prevailing assumptions and issues in coaching, offering implications for future coaching research and coaching practice.......In the coaching context of an ongoing search for evidence-based research, and increasing interest in the ‘active ingredients’ of coaching the impetus for ‘the coaching relationship – and beyond’ was the quest for deeper understanding of the coaching relationship as well as its influence...... on the outcomes of coaching. It is a presentation, on factors specifically related to engagement of the coachee and building effective coaching relationships: (a) a study examining the power relations between employee coachee and coach from the middle manager coach perspective, highlighting coaching relationship...

  18. Clinical biochemistry

    Science.gov (United States)

    Alexander, W. C.; Leach, C. S.; Fischer, C. L.

    1975-01-01

    The objectives of the biochemical studies conducted for the Apollo program were (1) to provide routine laboratory data for assessment of preflight crew physical status and for postflight comparisons; (2) to detect clinical or pathological abnormalities which might have required remedial action preflight; (3) to discover as early as possible any infectious disease process during the postflight quarantine periods following certain missions; and (4) to obtain fundamental medical knowledge relative to man's adjustment to and return from the space flight environment. The accumulated data presented suggest that these requirements were met by the program described. All changes ascribed to the space flight environment were subtle, whereas clinically significant changes were consistent with infrequent illnesses unrelated to the space flight exposure.

  19. Clinical Studies

    DEFF Research Database (Denmark)

    Pallesen, Ulla

    and repair? Have new materials improved longevity? Are there still clinical and material problems to be solved? And what has the highest impact on longevity of posterior resin restorations – the material, the dentist, the patient or the tooth? These matters will be discussed on the basis of the literature......Within the last 25 years composite resin materials have in many countries successively replaced amalgam as a restorative for posterior teeth. Resin materials and bonding systems are continuously being improved by the manufactures, adhesive procedures are now included in the curriculum of most...... universities and practicing dentists restore millions of teeth throughout the World with composite resin materials. Do we know enough about the clinical performance of these restorations over time? Numerous in vitro studies are being published on resin materials and adhesion, some of them attempting to imitate...

  20. FRANCHISOR-FRANCHISEE RELATIONSHIP QUALITY: TIME OF RELATIONSHIP AND PERFORMANCE

    Directory of Open Access Journals (Sweden)

    Luís Fernando Varotto

    2016-11-01

    Full Text Available Franchise literature disputes how the relationship between franchisors and franchisees develops over time. Traditional lifecycle theory views relationships following an ascendant curve, in which relationship quality and performance strengthen over time. Another perspective better reflects the peculiarities of the franchisor-franchisee relationship, indicating that relationship quality in franchise systems follows a U-shaped curve. There is also limited research on the moderating effect of time on the relationship between relational variables and outcomes. This study sheds light on the influence of relationship duration on relationship quality and financial performance in the franchisee-franchisor relationship. Using a self-report survey from a sample of 342 franchisees, mean and regression analyses are conducted to test relationships. Results confirm the time effect on franchisor-franchisee relationship quality and performance, but the hypothesized shape of relationship phases is only partially confirmed. Moreover, time has a positive moderating effect on the impact of relationship quality on financial performance.

  1. Cross border relationships

    DEFF Research Database (Denmark)

    Singla, Rashmi; Sriram, Sujata

    2010-01-01

    -being of not just the migrant population, but also the host communities. These relationships represent the microcosm of societal and cultural integration and cohesion at the broader levels. Studies of how and how well migrants, especially youth handle migration indicate transformations in paradigms as both...... in which they were born. These movements also imply human relationships across the borders in different contexts with various cultural, psychological consequences. Relationships of members of migrant groups with each other, and also with the host community have important implications on the health and well...

  2. Memory clinics

    OpenAIRE

    Jolley, D; Benbow, S M; Grizzell, M

    2006-01-01

    Memory clinics were first described in the 1980s. They have become accepted worldwide as useful vehicles for improving practice in the identification, investigation, and treatment of memory disorders, including dementia. They are provided in various settings, the setting determining clientele and practice. All aim to facilitate referral from GPs, other specialists, or by self referral, in the early stages of impairment, and to avoid the stigma associated with psychiatric services. They bring ...

  3. Clinical practice

    OpenAIRE

    2011-01-01

    Cerebral palsy (CP) is the most common physical disability in early childhood. The worldwide prevalence of CP is approximately 2–2.5 per 1,000 live births. It has been clinically defined as a group of motor, cognitive, and perceptive impairments secondary to a non-progressive defect or lesion of the developing brain. Children with CP can have swallowing problems with severe drooling as one of the consequences. Malnutrition and recurrent aspiration pneumonia can increase the risk of morbidity ...

  4. Changes to Your Relationships

    Science.gov (United States)

    ... Last name: Email: * Zip: * *required We will not sell or share your name. Changes to Your Relationship ... Kids and Teens Activities Resolving Family Conflicts ALZConnected Online Community Back to top Search local resources Get ...

  5. Expect Respect: Healthy Relationships

    Science.gov (United States)

    ... Pediatrician Ages & Stages Prenatal Baby Toddler Preschool Gradeschool Teen Dating & Sex Fitness Nutrition Driving Safety School Substance Abuse Young Adult Healthy Children > Ages & Stages > Teen > Dating & Sex > Expect Respect: Healthy Relationships Ages & Stages Listen Español ...

  6. Human-Forest Relationships

    DEFF Research Database (Denmark)

    Ritter, Eva; Dauksta, Dainis

    2012-01-01

    The relationship between forests and people goes back to the early development of civilisation. However, parallel with technical innovations and an increasing urbanisation of the society, an alienation from nature has taken place......The relationship between forests and people goes back to the early development of civilisation. However, parallel with technical innovations and an increasing urbanisation of the society, an alienation from nature has taken place...

  7. Effects of job satisfaction and life satisfaction on the relationship between emotional intelligence and work engagement of clinical nurses%工作满意度和生活满意度在临床护士情绪智力和工作投入关系中的作用

    Institute of Scientific and Technical Information of China (English)

    冯婷; 闫晓飞; 胡雪慧; 苏景宽

    2015-01-01

    目的 探讨工作满意度和生活满意度在临床护士情绪智力和工作投入关系中的作用,为管理者采取针对性的措施提升护士工作投入提供有效依据. 方法 采用情绪智力量表、工作满意度量表、生活满意度量表和工作投入量表,对西安市某三级甲等医院使用随机抽样方法选取的380 名临床护士进行调查,采用SPSS 16. 0统计软件对数据进行分析. 结果 发放问卷380份,收回问卷378份,经过初步分析,剔除无效问卷14 份,则有效问卷364 份. 364 名护士情绪智力的总分为(60. 41 ± 8. 11)分,生活满意度总分为(19. 26 ± 6. 85)分;工作满意度总分为(71. 85 ± 10. 21)分;工作投入总分为(82. 18 ± 16. 62)分. 临床护士的情绪智力、生活满意度和工作满意度与工作投入均呈正相关( r=0. 40~0. 65,P<0. 01),临床护士的情绪智力对工作投入有直接的预测作用,工作满意度、生活满意度均在临床护士情绪智力与工作投入的关系中存在部分中介作用. 结论 工作满意度、生活满意度均在临床护士情绪智力与工作投入的关系中存在部分中介作用,护理管理者应有效提升临床护士的情绪智力,帮助护士从个人角度创造更高的工作满意度和生活满意度,有益于临床护士工作投入水平的提高.%Objective To explore the effects of job satisfaction and life satisfaction on the relationship between emotional intelligence and work engagement of the clinical nurses, in order to provide effective evidence of corresponding measures for managers to enhance nurses′work engagement. Methods A total of 380 clinical nurses were selected randomly from a tertiary referral hospital in Xi′an, who were investigated by emotional intelligence scale, job satisfaction scale, life satisfaction scale, and work engagement scale. Results We distributed 380 questionnaires, collected 378, and rejected 14 invalid one after analysis, so it was total 364

  8. 研究 MTT 法测定肿瘤细胞药物的敏感性与临床用药之间的关系%To study the relationship between the drug sensitivity of tumor cel s and clinical drug use by MTT method

    Institute of Scientific and Technical Information of China (English)

    韩洁

    2016-01-01

    目的:研究分析 MTT 法测定肿瘤细胞药物的敏感性与临床用药之间的关系。方法选取我院自2013年3月———2014年5月收治的120例7类不同肿瘤患者,分别为膀胱癌50例、宫颈癌15例、卵巢癌18例、子宫内膜癌13例、肺癌、胃癌、肠癌各位8例,均需要进行 MTT 法测定肿瘤细胞药物的敏感性。对其临床资料进行回顾性分析,并与临床实际用药进行对比,对其临床疗效作出评价。结果分别对以上7类肿瘤样本进行统计分析,对比相同类型肿瘤不同样本两者之间的抑制率差异;同时运用公式计算同一样本对每一中抗癌药物的平均抑制率,然后对比临床上治疗该类型肿瘤的药物情况。最后结合临床医生对患者术后用药的具体情况,评价药物敏感性测定结果对临床个体化治疗的影响以及实际意义。结论对患者进行肿瘤细胞体外药物敏感性测定,能够为肿瘤患者的临床治疗提供重要的参考和建议。%Objective To study the relationship between the sensitivity of tumor cel s and the clinical use of MTT .Methods 7 cases of 120 dif erent kinds of tumor patients,50 cases of bladder cancer,15 cases of cervical cancer,18 cases of ovarian cancer,13 cases of endometrial carcinoma,8 cases of lung cancer,gastric cancer,colon cancer,cases were selected,and the clin-ical data were retrospectively analyzed.Results the 7 kinds of tumor samples were statistical y analyzed,and compared with the same type of tumor samples,and the average inhibition rate of each medium was calculated by using the formula.At last,combined with the specific circumstances of the clinical doctors,the drug sensitivity test results were evaluated,and the clinical ef ect of the treatment and the practical significance.Conclusion the results of drug sensitivity test of tumor cel s in vitro can provide important reference for the clinical treatment of tumor patients .

  9. The relationship between clinical nurses' critical thinking disposition and competence of nursing ethical decision making%临床护士评判性思维态度倾向性与护理伦理决策能力的相关性研究

    Institute of Scientific and Technical Information of China (English)

    高静; 吴晨曦; 杨翔宇; 张婷; 柏丁兮; 张倩; 刘晓云

    2013-01-01

    目的 了解临床护士评判性思维态度倾向性和护理伦理决策能力的现状及影响因素,分析两者之间的相关性.方法 在四川省5所三级甲等综合性医院中分层随机抽取359名临床护士进行问卷调查,问卷由一般情况调查表、护理伦理决策量表(JAND)及中文版评判性思维态度倾向性问卷(CTDI-CV)3部分组成.结果 临床护士CTDI-CV总均分为(285.06:±26.79)分,JAND总均分为(267.91±16.62)分.护理伦理决策能力的影响因素为学历、获取专业知识的途径、护理伦理决策培训.评判性思维态度倾向性与护理伦理决策能力呈正相关.结论 临床护士护理伦理决策能力及评判性思维态度倾向性得分处于中等水平,两者呈正相关,在学校教育和医院继续教育中,可通过加强对护士评判性思维态度倾向的培养来提高其护理伦理决策能力.%Objective To investigate the level of the clinical nurses' critical thinking disposition and the competence about nursing ethical decision making,and analyze the relationship between them.Methods A total of 359 clinical nurses were recruited by stratified random sampling method.They were investigated with general situation questionnaire,critical thinking disposition inventory-Chinese version (CTDI-CV) and judgment about nursing decisiors(JAND).Results The total score of CTDI-CV was (285.06±26.79),the total score of JAND was(267.91±16.62).The influencing factors of clinical nurses' competence about nursing ethical decision making was education background,ways of obtaining occupational knowledge,training of nursing ethical decision.The clinical nurses' competence about nursing ethical decision making was positively correlated with critical thinking disposition.Conclusions The level of clinical nurses' critical thinking disposition and competence about nursing ethical decision making are medium,in order to improve the level of competence about nursing ethical decision making

  10. What Are Clinical Trials?

    Science.gov (United States)

    ... of this page please turn Javascript on. Feature: Clinical Trials What Are Clinical Trials? Past Issues / Fall 2010 Table of Contents Clinical ... conducted all the time. The Different Phases of Clinical Trials Clinical trials related to drugs are classified into ...

  11. Participating in Clinical Trials

    Science.gov (United States)

    ... this page please turn Javascript on. Participating in Clinical Trials About Clinical Trials A Research Study With Human Subjects A clinical ... to treat or cure a disease. Phases of Clinical Trials Clinical trials of drugs are usually described based ...

  12. Participating in Clinical Trials

    Medline Plus

    Full Text Available ... Z > Participating in Clinical Trials: About Clinical Trials In This Topic About Clinical Trials Risks and Benefits ... of this page please turn Javascript on. Participating in Clinical Trials About Clinical Trials A Research Study ...

  13. Clinical research before informed consent.

    Science.gov (United States)

    Miller, Franklin G

    2014-06-01

    Clinical research with patient-subjects was routinely conducted without informed consent for research participation prior to 1966. The aim of this article is to illuminate the moral climate of clinical research at this time, with particular attention to placebo-controlled trials in which patient-subjects often were not informed that they were participating in research or that they might receive a placebo intervention rather than standard medical treatment or an experimental treatment for their condition. An especially valuable window into the thinking of clinical investigators about their relationship with patient-subjects in the era before informed consent is afforded by reflection on two articles published by psychiatric researchers in 1966 and 1967, at the point of transition between clinical research conducted under the guise of medical care and clinical research based on consent following an invitation to participate and disclosure of material information about the study. Historical inquiry relating to the practice of clinical research without informed consent helps to put into perspective the moral progress associated with soliciting consent following disclosure of pertinent information; it also helps to shed light on an important issue in contemporary research ethics: the conditions under which it is ethical to conduct clinical research without informed consent.

  14. The Relationship of Personality to Eating Disorders

    Directory of Open Access Journals (Sweden)

    Mohammad Ali Besharat

    2008-01-01

    Full Text Available This paper highlights a variety of personality disorders in individuals with eating disorder and also emphasizes the importance of identifying clinically meaningful eating disorders subtypes based on concurrent personality disorder. The relationship between personality disorders and eating disorders is an important issue as this association has implications for assessment and treatment. Different hypotheses concerning the relationship between personality disorders and eating disorders will be reviewed. The prevalence rates of concomitant personality disorder diagnoses in eating disorder patients is highlighted to illustrate some of the pertinent conceptual issues concerning the meaning of the co-occurrence of separately defined diagnostic entities. The literature review reveals a robust finding that patients with ersonality pathology have a poorer response to treatment of Axis I disorders than those without such pathology. It is also argued that therapeutic relationship deserves more attention in the assessment and treatment of eating disorder patients with a co morbid personality disorder.

  15. Psychiatrists and clinical psychologists

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2006-03-01

    Full Text Available Psychiatrists and clinical psychologists share an inevitable, if rather uneasy, relationship. So very much like a modern marriage. Can't do without it, can't get out of it. Both sides contemplate divorce often. Think of separation by mutual consent. Even keep threatening as they rave and rant. Have secret, and not so secret, flings on the side. But, like the proverbial homing bird, or the conservative Indian arranged marriage, have no option but to stick it out with each other. Psychiatrists are otherwise good people. But that does not make them immune to handling clinical psychologists with the condescending tolerance and patronizing acceptance that teachers, for example, have towards rambling students. Or the rich have towards the poor. This does not take long to get converted into exasperation and smirky asides in the less charitable amongst the psychiatrists. Not that clinical psychologists are very helpful in motivating the psychiatrists to change for the better. For they, like most people in their position, over react and get aggressive when confronted with this attitude. And understandably so. However, it is time both realized their attitudes were not helpful either for mutual interaction, or growth of the Mental Health Movement at large. We can understand why psychiatrists behave the way they do. They are exposed to this same condescending-patronising attitude from their own peers in the medical profession. Their medical colleagues have yet to develop a feeling of healthy respect for psychiatry. Psychiatrists, no doubt, feel this is unjustified, but their peers are still in a position to deny them the respect and acceptance they seek. What they get from their medical colleagues, they unwittingly pass on to their clinical psychologist colleagues. But understanding why it occurs does not absolve them of their responsibility to behave more rationally, rather than emotionally, with the latter. [No abstract available.

  16. Investigating subjective attributes of quality for videos displayed with local backlight dimming

    DEFF Research Database (Denmark)

    Mantel, Claire; Bech, Søren; Forchhammer, Søren;

    2014-01-01

    This paper investigates what composes the quality of videos displayed on LCD with local backlight dimming. In a sub- jective experiment, participants assessed the level of nine attributes defined using the Qualitative Descriptive Anal- ysis method. Results show that three attributes (Contrast...

  17. Study on the relationship among psychological resilience, work stress, and anxiety and depression of psychiatric clinical staff%精神科医护人员心理韧性、工作压力与焦虑抑郁情绪关系

    Institute of Scientific and Technical Information of China (English)

    文超; 蒋春雷; 谭莉娜; 李桂克; 刘博

    2014-01-01

    Objective To explore the psychological resilience of psychiatric clinical staffs and its relationship among work stress, and anxiety and depression .Methods Two hundred and twenty psychiatric clinical workers in 4 hospitals in the Guangxi Zhuang Autonomous Region were sampled and tested by Chinese Version of Connor -Davidson Resilience Scale , Clinical Staff Occupational Stressors Scale , Self Rating Anxiety Scale and Self Rating Depress Scale .According to the scores of psychological resilience , the subjects were divided into 3 groups of high resilience , medium resilience and low resilience.Results There job stress scores of high resilience group were lower than those of the medium and low resilience groups ( P <0.01 ) .And the anxiety and depression scores among different resilience groups were also significantly different (P<0.05), showing high resilience group clinical workers ’ anxiety and depression emotion [ the standardized regression coefficient (β) were -0.255, -0.325;P<0.01];work stress could positively predict the psychiatric clinical workers’ anxiety and depression emotion (βwere 0.247, 0.185;P<0.01); mediation effects of resilience among work stress and anxiety, depression emotion were significant (P<0.01).The mediating effect inspection results showed βof anxiety and depression to work stress dropped from 0.298 and 0.258 to 0.210 and 0.144 respectively after using the psychological resilience as a mediating variable .Conclusion Resilience and work stress are significant predictors of anxiety and depression emotion of psychiatric clinical staff , and the resilience partially mediates the relationship among work stress and anxiety , depression.%目的:探讨精神科医护人员心理韧性、工作压力与焦虑抑郁情绪的关系。方法采用心理韧性量表、临床医护人员工作压力源量表、焦虑自评量表

  18. Conflict resolution in adolescent relationships

    NARCIS (Netherlands)

    van Doorn, M.D.

    2008-01-01

    Conflict is an inevitable feature of social relationships. When people interact, disagreements may arise. Especially in close relationships, people sometimes disagree. Although conflict might jeopardize relationships, conflict is not necessarily detrimental. The way conflicts are handled is importan

  19. Managing inter-organizational relationships

    DEFF Research Database (Denmark)

    Hald, Kim Sundtoft

    2005-01-01

    orweakened by partner- comfortability and dependability. Then we show how partnersperceived attraction towards an industrial company can be managed using a combinationof structural- and behavioral adjustments.Key words: Inter-organizational relationships; Relationship Management; Relationship...

  20. Using a clinical collaborative model for nursing education: application for clinical teaching.

    Science.gov (United States)

    Maguire, Denise J; Zambroski, Cheryl H; Cadena, Sandra V

    2012-01-01

    The promise of a clinical collaborative model (CCM) is that it engages hospital partners in a mutually beneficial partnership by providing the entire student clinical experience in one institution. The CCM prepares students for the day-to-day reality of patient care through the use of individual staff nurse preceptors, enhancing the relationship between the student and hospital upon graduation. The authors describe a successful paradigm for student nurse clinical education across the baccalaureate program.

  1. 新生儿缺氧缺血性脑病分度与磁敏感加权成像出血检出率的相关性研究%Study on relationship between clinical grading and detection rate of hemorrhage by susceptibility weighted imaging for newborns with hypoxic-ischemic encephalopathy

    Institute of Scientific and Technical Information of China (English)

    张雪雁; 李军

    2014-01-01

    目的:研究新生儿缺氧缺血性脑病(HIE)临床分度与磁敏感加权成像(SWI)出血灶检出率的相关性。材料与方法选取30例经临床诊断为HIE的患儿进行SWI扫描,根据临床分度分别统计轻、中、重度患儿中SWI检出颅内出血灶的患儿例数,针对三种临床分度患儿的颅内出血灶检出率进行χ2检验及χ2分割法两两比较。结果三种临床分度患儿的颅内出血灶检出率具有统计学差异(χ2=12.438,P=0.02);轻度HIE患儿出血灶检出率分别低于中度HIE患儿(χ2=5.690,P=0.017)和重度HIE患儿(χ2=9.545,P=0.002),中度和重度HIE患儿出血灶检出率无统计学差异(χ2=1.173,P=0.279)。结论:轻度HIE患儿的SWI出血灶检出率明显低于中度和重度,通过SWI有无发现出血灶可以有效判断HIE患儿病情轻重。%Objective: To study the relationship between clinical grading and detection rate of hemorrhage by susceptibility weighted imaging (SWI) for newborns with hypoxic-ischemic encephalopathy (HIE). Materials and Methods: 30 cases of newborns with HIE diagnosed by clinical criteria were selected to receive SWI sequence scan. These newborns were divided into 3 groups according to clinical grading (mild, moderate, severe) and numbers of newborns in which intracranial hemorrhage detected by SWI were counted.χ2 test and partitions ofχ2 method were performed to compare the detection rate of hemorrhage by SWI according to clinical grading. Results:There had statistical difference for the detection rate of hemorrhage by SWI among three groups (χ2=12.438, P=0.02). The detection rate of hemorrhage by SWI for mild newborns with HIE was signiifcant lower than that of moderate newborns with HIE (χ2=5.690, P=0.017) and that of severe newborns with HIE (χ2 =9.545, P=0.002). There had no statistical difference for the detection rate of hemorrhage by SWI between moderate and severe newborns with HIE (χ2=1.173, P=0.279). Conclusions

  2. Location, location, location: applying spatial statistics to the relationship landscape.

    Science.gov (United States)

    Wood, Nathan D

    2014-12-01

    The desire to understand relationships is a passion shared by professionals in research, clinical, and educational settings. Questionnaires are frequently used in each of these settings for a multitude of purposes-such as screening, assessment, program evaluation, or establishing therapeutic effectiveness. However, clinical issues arise when a couple's answers on questionnaires do not match clinical judgment or lack clinical utility, while statistical problems arise when data from both partners are put into analyses. This article introduces the use of geospatial statistics to analyze couple data plotted on a two-dimensional "relational map." Relationship maps can increase assessment sensitivity, track treatment progress, and remove statistical issues typically associated with couple data. This article briefly introduces core assumptions of spatial models, illustrates the use of spatial models in creating a relational landscape of divorce, offers suggestions for the use of relational maps in a clinical setting, and explores future research ideas.

  3. Antecedents of Customer Relationship Termination

    DEFF Research Database (Denmark)

    Geersbro, Jens; Ritter, Thomas

    To end business relationships, or to more actively terminate relationships, has long been acknowledged as part of customer relationship management. However, compared to other elements such as initiation and maintenance of relationships, little is known about the termination of business...... relationships as a managerial task. This paper contributes by (1) developing a conceptualization of relationship termination competence and (2) analyzing its antecedents. The empirical results identify termination acceptance, definition non-customers, organizational relationship termination routines......, and motivation as significant antecedents. Because of this, managers need to develop their organizations in order to use relationship termination as a vital strategy....

  4. Cadmium and zinc relationships.

    Science.gov (United States)

    Elinder, C G; Piscator, M

    1978-08-01

    Cadmium and zinc concentrations in kidney and liver have been measured under different exposure situations in different species including man. The results show that zinc increases almost equimolarly with cadmium in kidney after long-term low-level exposure to cadmium, e.g., in man, horse, pig, and lamb. In contrast, the increase of zinc follows that of cadmium to only a limited extent, e.g., in guinea pig, rabbit, rat, mouse, and chicks. In liver, the cadmium--zinc relationship seems to be reversed in such a way that zinc increases with cadmium more markedly in laboratory animals than in higher mammals. These differences between cadmium and zinc relationships in humans and large farm animals and those in commonly used laboratory animals must be considered carefully before experimental data on cadmium and zinc relationships in laboratory animals can be extrapolated to humans.

  5. Clinical guidelines.

    Science.gov (United States)

    Uppal, Elaine

    2016-01-01

    This article is part of the Advancing practice series which is aimed at exploring practice issues in more depth, considering topics that are frequently encountered and facilitating the development of new insights. Elaine Uppal focuses on the importance of all midwives developing guideline writing skills to ensure that local, national and international midwifery/maternity guidelines are up to date, relevant and reflect midwifery knowledge alongside 'gold' standard evidence. The article aims to consider the development, use and critical appraisal of clinical guidelines. It will define and explain guidelines; discuss their development and dissemination; and consider issues relating to their use in practice. Techniques to critique and develop guidelines using the AGREE tool will be outlined in the form of practice challenges to be undertaken by the individual or in a group.

  6. An ambiguous relationship

    DEFF Research Database (Denmark)

    Søndergaard Larsen, Lene; Hedegaard Larsen, Birte; Birkelund, Regner

    2013-01-01

    to qualitative data analysis. Results:  The qualitative meta-synthesis resulted in the heading An Ambiguous Relationship under which three core categories illustrate the hospitalized patients’ different interaction roles. The core categories were as follows: (i) the fellow patient experienced as an enforced...... and volunteered participation. Typically, the social interaction was experienced as giving and was referred to in positive terms but recurrently, the opposite was experienced too. The ambiguity of the relationship clearly emerged in all of the synthesized themes presented in this article. Implications...

  7. 慢性肾衰虚实兼证面诊特征信息与肾功能的关联研究%Studies on Relationship Between the Facial Complexion Characters And Kidney Function in TCM Clinical Syndrome of Chronic Renal Failure

    Institute of Scientific and Technical Information of China (English)

    曹燕亚; 张瑞仪; 张伟妃; 郑晓燕; 赵洁; 李福凤

    2012-01-01

    目的:探讨慢性肾衰邪实兼证面色参数与病理生化指标的相互关系.方法:应用中医面色检测仪检测慢性肾功能衰竭患者面色特征信息,同步收集其病史资料及病理生化指标.结果:慢性肾衰虚实兼证各面色参数与病理生化指标之间存在一定的相关性:虚兼湿浊证面色参数中黑色比例与尿酸的相关系数为-0.158;虚兼湿热证面色指数与尿素氮的相关系数为-0.278.结论:慢性肾衰虚实兼证的面色参数与临床病理生化指标尿素氮、血肌酐、尿酸、肾小球滤过率存在一定的相关性,表明中医临床病证面色变化可用现代医学语言来诠释.%Objective:To discuss the relationship of the facial color parameters and the pathological - biochemical indicators of the CRF with different syndromes. Methods: Applying TCM facial color detector apparatus to gathering the facial color characteristic information of CRF patients. Collecting the medical history datum and pathological - biochemical indicators at the same time. Results:There are some certain correlations on the facial color parameters and pathological - biochemical indicators among the deficiency - excess Syndromes of chronic renal failure: wet muddy syndrome, the black proportion of facial color parameters with BNA correlation coefficients was -0. 158; hot and damp syndrome, facial color index with BUN correlation coefficients was -0.278. Conclusions: Chronic renal failure five syndromes facial color parameters and clinical pathology blood urea nitrogen, serum creatinine, uric acid, glomerular filtration rate and albumin exists certain correlation, indicating that facial color changes in Chinese medicine clinical syndrome can interpret the language of modern medicine Language.

  8. 医科院校临床医学专业学生家庭功能与考试焦虑的关系研究%Studying on the relationship between family function and test anxiety among clinical medical students in medical college

    Institute of Scientific and Technical Information of China (English)

    孔令玲; 于国华; 张骞; 曲海英; 徐娜

    2014-01-01

    目的:探讨临床医学专业学生家庭功能与考试焦虑的关系。方法采用整群取样,从山东省某医学院校选取645名大学生为被试,应用家庭功能评定量表、考试焦虑量表进行调查。结果存在考试焦虑不适感的学生占61.2%;高家庭功能组和低家庭功能组在考试焦虑水平上存在显著性差异(t=-5.15,P<0.01);临床医学专业学生家庭功能与考试焦虑存在显著正相关(t=0.238,P<0.01);多元回归显示,总的功能和角色两个因子对考试焦虑有显著的预测作用(β=0.145,β=0.131;P均<0.01)。结论家庭功能是影响临床医学专业学生考试焦虑的一个重要因素。%Objective To explore the relationship between family function and test anxiety among clinical medical students .Meth-ods Totally 645 clinical graduates in some medical university of Shandong were selected with cluster sampling and investingated with Family Assessment Device and Test Anxiety .Results 38.8%of participants had test anxiety discomforts .There were significant differ-ence on test anxiety between high family function group and low family function group (t=-5.15,P<0.01).There was positive corre-lation between family function and test anxiety (t=0.238,P<0.01).Multi-regression analysis showed that:general function and explic-it character could predict test anxiety (β=0.145,β=0.131;respective,P﹤0.01).Conclusion There is close correlation between family function and test anxiety and family function has a great influence on test anxiety of the students .

  9. Need fulfillment in polyamorous relationships.

    Science.gov (United States)

    Mitchell, Melissa E; Bartholomew, Kim; Cobb, Rebecca J

    2014-01-01

    Polyamory is characterized by simultaneous consensual romantic relationships with multiple partners. Polyamory allows individuals to fulfill their relationship needs with multiple romantic partners, yet researchers have not identified how having needs met in one romantic relationship may be related to relationship outcomes in a concurrent relationship. Polyamorous individuals (N=1,093) completed online measures of need fulfillment, relationship satisfaction, and commitment for two concurrent romantic relationships. Participants reported high levels of need fulfillment and satisfaction in both relationships. Need fulfillment with one partner negatively predicted approximately 1% of the variance in relationship satisfaction with the other partner; however, there was no association between need fulfillment with one partner and commitment to the other. Generally, the findings suggest that polyamorous relationships are relatively independent of one another. This study provides initial evidence that polyamory may be a viable and fulfilling alternative way of conducting intimate relationships.

  10. Vulnerability of the clinical method

    Directory of Open Access Journals (Sweden)

    José Carlos Hernández Aragonés

    2010-12-01

    Full Text Available This article is aimed at outlining the general aspects that undermine the use of the clinical method in everyday medical practice and also at exposing those that cause a negative effect on the use of the various steps leading to the correct diagnosis and treatment of a patient. A presentation is made on the issues and situations that may contribute not to take into account the clinical method and the requirements for its implementation. Finally, it is concluded that the importance and appropriate management of the clinical method is not still widely known and that the decline of the doctor-patient relationship is a key element that hinders its application.

  11. Impact of QRS duration on the relationship between left ventricle lead electrical delay and clinical response after cardiac resynchronization therapy%QRS时限对左心室导线电延迟与心脏再同步治疗长期疗效相关性的影响

    Institute of Scientific and Technical Information of China (English)

    樊晓寒; 华伟; 陈柯萍; 孙欣; 杨新伟; 刘志敏; 郑黎辉; 张澍

    2014-01-01

    目的 探讨QRS时限是否影响左心室导线电延迟(LVLED)与心脏再同步治疗(CRT)长期疗效的相关性.方法 前瞻性入选2011年10月至2013年3月在阜外心血管病医院成功植入CRT患者,在围术期测量Q波起始到左心室导线感知波最高峰的时间间距(QLV)反映LVLED.根据患者基线QRS时限分为宽QRS组(≥150 ms)和窄QRS