WorldWideScience

Sample records for clinical investigator-subject relationship

  1. The clinical investigator-subject relationship: a contextual approach

    OpenAIRE

    Resnik David B

    2009-01-01

    Abstract Background The nature of the relationship between a clinical investigator and a research subject has generated considerable debate because the investigator occupies two distinct roles: clinician and scientist. As a clinician, the investigator has duties to provide the patient with optimal care and undivided loyalty. As a scientist, the investigator has duties to follow the rules, procedures and methods described in the protocol. Results and conclusion In this article, I present a con...

  2. Research and Clinical Practice Relationship

    OpenAIRE

    Ashammakhi N

    2008-01-01

    To The Editor: I highly value and greet the authors for their editorial. Many important issues related to medical education and its future in Libya have been discussed in this paper [1]. One important point that has been addressed and I feel deserves attention is the “abnormal” relationship between clinical practice and research in Libya. From discussions with colleagues, this problem somehow has evolved from a misconception about educational and training systems that may have occurred in the...

  3. Research and clinical practice relationship

    Directory of Open Access Journals (Sweden)

    Ashammakhi N

    2008-01-01

    Full Text Available To The Editor: I highly value and greet the authors for their editorial. Many important issues related to medical education and its future in Libya have been discussed in this paper [1]. One important point that has been addressed and I feel deserves attention is the “abnormal” relationship between clinical practice and research in Libya. From discussions with colleagues, this problem somehow has evolved from a misconception about educational and training systems that may have occurred in the past. It may also be related to the lack of attention to research that has long existed in Libya [2,3]. The other aspect, shared with many other developing countries, is the misconception of research as unimportant or a luxury aspect of medicine. When it comes to understanding how a system (including healthcare can be updated and developed, the answer is vague! One important reason is a lack of understanding of the impact that research has on developing methods. In developed countries, research is the main academic distinction that leads to appointments for coveted positions in the system and is an important factor for academic promotion. In Libya, there remain arguments about who will be awarded Chair of university clinical departments. Such a post should no doubt be given to those with established academic achievements. When highly qualified persons are at the top of the pyramid this leads to further progress and enhanced research and advancement. The authors have discussed the point of having proper search committees for leadership and faculty positions. I believe that it will help eliminate the current stagnation and help to create innovative solutions. This should lead to improved medical education, health services, and ultimately impact the quality of life of all Libyan citizens.

  4. Clinical Relationships Extraction Techniques from Patient Narratives

    Directory of Open Access Journals (Sweden)

    Wafaa Tawfik Abdel-Moneim

    2013-01-01

    Full Text Available The Clinical E-Science Framework (CLEF project was used to extract important information from medical texts by building a system for the purpose of clinical research, evidence-based healthcare and genotype-meets-phenotype informatics. The system is divided into two parts, one part concerns with the identification of relationships between clinically important entities in the text. The full parses and domain-specific grammars had been used to apply many approaches to extract the relationship. In the second part of the system, statistical machine learning (ML approaches are applied to extract relationship. A corpus of oncology narratives that hand annotated with clinical relationships can be used to train and test a system that has been designed and implemented by supervised machine learning (ML approaches. Many features can be extracted from these texts that are used to build a model by the classifier. Multiple supervised machine learning algorithms can be applied for relationship extraction. Effects of adding the features, changing the size of the corpus, and changing the type of the algorithm on relationship extraction are examined.

  5. [Relationship between residual milk and clinical mastitis in dairy cattle].

    Science.gov (United States)

    Cording, F; Hoedemaker, M; Krömker, V

    2013-01-01

    Mastitis in cattle is an infection of the mammary gland caused by infection, toxins and/or trauma. Currently, it is assumed that there is a correlation between higher amounts of residual milk and the incidence of clinical mastitis. The amount of residual milk can be examined using different methods. Higher amounts of residual milk may result from an insufficient teat condition and individual detachment settings of milking units. To date, scientific literature has already discussed the relationship between high amounts of residual milk, undermilking and the occurrence of clinical mastitis. The present paper reviews the current status of knowledge regarding residual milk and risk of mastitis.

  6. [Relationship of statistics and data management in clinical trials].

    Science.gov (United States)

    Chen, Feng; Sun, Hua-long; Shen, Tong; Yu, Hao

    2015-11-01

    A perfect clinical trial must nave a solid study design, strict conduction, complete quality control, non-interference of statistical result, and acceptable risk-benefit ratio. To reach the target, the quality control (QC) should be performed from the study design to conduction, from the analysis to conclusion. We discuss the relationship between data management and biostatistics from the statistical point of view, and emphasize the importance of the statistical concept and methods in the improvement of data quality in clinical data management.

  7. Learning to be a midwife in the clinical environment; tasks, clinical practicum hours or midwifery relationships.

    Science.gov (United States)

    Ebert, Lyn; Tierney, Olivia; Jones, Donovan

    2016-01-01

    Discussions continue within the midwifery profession around the number of and type of clinical experiences required to ensure competent midwifery graduates. Introduction of the three year Bachelor of Midwifery in Australia, almost two decades ago, was intended to reduce the pressure students were under to complete their academic requirements whilst ensuring students developed midwifery practice that encapsulates the philosophical values of midwifery. Currently, midwifery students are mandated to achieve a minimum number of clinical skills and Continuity of Care Experience (CCE) relationships in order to register upon completion of their degree. To achieve these experiences, universities require students to complete a number of clinical practicum hours. Furthermore students are required to demonstrate competent clinical performance of a number of clinical skills. However, there is no evidence to date that a set number of experiences or hours ensures professional competence in the clinical environment. The aim of this paper is to promote discussion regarding the mandated requirements for allocated clinical practicum hours, specified numbers of clinical-based skills and CCE relationships in the context of learning to be a midwife in Australia. PMID:26409311

  8. The Relationship between Clinical Competence and Clinical Self-efficacy among Nursing and Midwifery Students

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    Shahla Mohamadirizi

    2015-12-01

    Full Text Available Introduction  Self-efficacy in clinical performance had an important role in applying competencies; also competencies and self-efficacy in clinical performance influenced to quality care of nursing and midwifery students. So the present study aimed to define the relationship between clinical competencies and clinical self-efficacy among nursing and midwifery students. Materials and Methods  This is a cross-sectional study conducted on 150 of nursing and midwifery students in Isfahan University of Medical Science, selected through two stage sampling in 2014. The participant completed questionnaires about personal/ educational characteristics and nursing competencies questionnaire (18 items and clinical self-efficacy scale (37 items. The data were analyzed by, Pearson statistical test, t-test, variance analysis through SPSS version16. Results The results showed that 50% (n=75 and 37.4% (n=56 of nursing and midwifery students had good clinical competence and clinical Self-Efficacy, respectively. Also the mean competencies and self-efficacy in clinical performance scores were 35.05± 1.2 and 76.03± 0.4 respectively. Pearson correlation coefficient showed that there was a positive linear correlation between the score of clinical competence and clinical self-efficacy (P

  9. Relationship of femorodistal bypass patency to clinical outcome. Iloprost Bypass International Study Group

    DEFF Research Database (Denmark)

    Watson, H R; Schroeder, T V; Simms, M H;

    1999-01-01

    To investigate the relationship between bypass patency, limb survival and clinical symptoms after femorodistal bypass procedures.......To investigate the relationship between bypass patency, limb survival and clinical symptoms after femorodistal bypass procedures....

  10. Relationship between Clinical Signs and Symptoms of Convergence Insufficiency

    Science.gov (United States)

    Bade, Annette; Boas, Mark; Gallaway, Michael; Mitchell, G. Lynn; Scheiman, Mitchell; Kulp, Marjean T.; Cotter, Susan A.; Rouse, Michael

    2014-01-01

    Purpose The percentage of children who are symptomatic has been shown to increase with the number of signs of convergence insufficiency (CI). Our goal was to investigate whether there is a relationship between the severity of the clinical signs of CI and symptom level reported in children with 3-sign symptomatic CI. Methods The Convergence Insufficiency Treatment Trial (CITT) enrolled 221 children with symptomatic CI from ages 9 to 17 years. Inclusion criteria included the following three signs of CI: (1) exophoria at near at least 4Δ greater than at distance, (2) insufficient positive fusional vergence (PFV) at near, and (3) a receded near point of convergence (NPC) of ≥ 6cm break. The relationships between the severity of each sign of CI (mild, moderate and severe) and the level of symptoms as measured by the Convergence Insufficiency Symptom Survey (CISS) at baseline were evaluated. Results Mean CISS scores were not significantly different between mild, moderate or severe exophoria (p=0.60), PFV blur (p=0.99), Sheard's criterion (p=0.89) or NPC break (p=0.84). There was also no difference in the frequency of subjects scoring at mild, moderate or severe levels on the CISS and the severity of each sign of CI. Correlations between individual clinical signs and the CISS score were very low and not statistically significant. Conclusions Among symptomatic children with a CISS score ≥ 16 and three clinical signs of CI, there is no further association between the severity of the clinical signs and their level of symptoms. PMID:23958713

  11. Clinical Relationship between Steatocholecystitis and Gallbladder Contractility Measured by Cholescintigraphy

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    Chang Seok Bang

    2015-01-01

    Full Text Available Objective. Contractility of gallbladder is known to be decreased in fatty gallbladder diseases. However, clinical estimation data about this relationship is still lacking. The aim of this study was to investigate the association between steatocholecystitis and contractility of gallbladder. Methods. Patients with cholecystitis (steatocholecystitis versus nonsteatocholecystitis who underwent cholescintigraphy before cholecystectomy were retrospectively evaluated in a single teaching hospital of Korea. The association of steatocholecystitis with contractility of gallbladder, measured by preoperative cholescintigraphy, was assessed by univariable and multivariable analysis. Results. A total of 432 patients were finally enrolled (steatocholecystitis versus nonsteatocholecystitis; 75 versus 357, calculous versus acalculous cholecystitis; 316 versus 116. In the multivariable analysis, age (OR: 0.94, 95% CI: 0.90–0.99, P=0.01 and total serum cholesterol (OR: 1.02, 95% CI: 1.01–1.04, P=0.04 were related to steatocholecystitis in patients with acalculous cholecystitis. Only age (OR: 0.97, 95% CI: 0.94–0.99, P=0.004 was significantly related to steatocholecystitis in patients with calculous cholecystitis. However, ejection fraction of gallbladder reflecting contractility measured by cholescintigraphy was not related to steatocholecystitis irrespective of presence of gallbladder stone in patients with cholecystitis. Conclusion. Ejection fraction of gallbladder measured by cholescintigraphy cannot be used for the detection or confirmation of steatocholecystitis.

  12. Relationship Between Histopathology and Clinical Prognosis of Invasive Pituitary Adenoma

    Institute of Scientific and Technical Information of China (English)

    LIYong; SHUKai; DONGFangyong; WANFeng; LEITing; LILing

    2005-01-01

    Objective: To study the relationship between histopathology and clinical prognosis of invasive pituitary adenoma subjected to transsphenoidal surgery. Methods: The enrolled were 82 patients with invasive pituitary adenomas undergoing transsphenoidal surgery during Jan. 2000 May 2003 in our department with full MR imaging findings, pathology data and follow-up information. The follow-up duration was 5-30 months. Results: MR imaging findings of invasive pituitary adenoma included: depression of the sellar floor, involvement of sphenoid sinus and cavernous sinus, breakthrough of diaphragma sellae,encasement of internal carotid artery, etc. Pathological examination revealed that the invasion rate of dura in sella turcica was the highest among the structures around tumor. Pituitary adenoma apoplexy was found in 20 cases (24.4%). The total removal rate for PRL-secreting adenomas was significantly lower than that for non-secreting adenomas (P<0.01), but non-, GH-, ACTH-secreting adenomas had no significant differences. The recurrence rate of PRL-secreting adenornas was higher than that of non- and GH-secreting adenomas (P<0.05). Conclusion: Among invasive pituitary adenomas, the therapeutic effects of nonand GH-secreting pituitary adenomas are better than that of PRL-secreting adenomas. Invasive biological behaviors of invasive pituitary adenomas result in radical operation failure and postoperative recurrence.

  13. Relationship between coronary arterial remodeling and clinical presentation

    Institute of Scientific and Technical Information of China (English)

    杨震坤; 沈卫峰; 张大东

    2003-01-01

    Objective To examine the relationship between coronary arterial remodeling and clinical presentation. Methods A total of 34 patients with acute (10 with recent myocardial infarction and 24 with unstable angina) and 26 with stable (8 with old myocardial infarction and 18 with stable angina) coronary syndrome underwent intravascular ultrasound (IVUS) before intervention. Target lesions were classified as soft or hard plaques. Q uantitative measurements of cross-sectional area (CSA) of external elastic memb rane (EEM), lumen and plaque were performed at the lesion site and at the proxim al and distal reference sites. Remodeling index (RI) was expressed by the ratio of EEM CSA at the lesion site to the mean EEM CSA of both proximal and distal r eference sites. Positive remodeling was defined as RI>1.05 and negative remode ling as RI<0.95. Results Soft plaque was observed more frequently in acute than in stable coronary syndrome (59% vs 31%), whereas hard plaque was more common in stable coronary syndrome (69% vs 41%) (P=0.03). The EEM CSA (15.11±2.89 mm2 vs 13.25±3.10 mm2, P=0.019) and plaque CSA (10.83±2.62 mm2 vs 9.30±2.84 mm 2, P =0.035) were significantly greater at target lesions in patients with acute r ather than stable coronary syndrome, while lumen CSA and percent area stenosis w ere similar in both groups. RI was significantly higher (1.08±0.16 vs 0.95 ±0.14, P=0.002) and positive remodeling was more frequent in acute corona ry syndrome (53% vs 23%, P=0.019), whereas negative remodeling was more com mon in stable coronary syndrome (58% vs 24%, P=0.007). Conclusions The study indicates that clinical characteristics of patients with coronary artery disease depend largely upon underlying types of coronary arterial remodeling .

  14. The relationships between clinical variables and renal parenchymal disease in pediatric clinically suspected urinary tract infection

    Directory of Open Access Journals (Sweden)

    Jung Lim Byun

    2010-02-01

    Full Text Available Purpose : To evaluate the significance of clinical signs and laboratory findings as predictors of renal parenchymal lesions and vesicoureteral reflux (VUR in childhood urinary tract infection (UTI. Methods : From July 2005 to July 2008, 180 patients admitted with a first febrile UTI at the Pediatric Department of Konkuk University Hospital were included in this study. The following were the clinical variables: leukocytosis, elevated C-reactive protein (CRP, positive urine nitrite, positive urine culture, and fever duration both before and after treatment. We evaluated the relationships between clinical variables and dimercaptosuccinic acid (DMSA scan and voiding cystourethrography (VCUG results. Results : VCUG was performed in 148 patients; of them, 37 (25.0% had VUR: 18 (12.2% had low-grade (I-II VUR, and 19 (10.5% had high-grade (III-V VUR. Of the 95 patients who underwent DMSA scanning, 29 (30.5% had cortical defects, of which 21 (63.6% had VUR: 10 (30.3%, low-grade (I-II VUR; and 11 (33.3%, high-grade VUR. Of the 57 patients who were normal on DMSA scan, 8 (14.0% had low-grade VUR and 6 (10.5% had high-grade VUR. The sensitivity, specificity, and positive and negative predictive values of the DMSA scan in predicting high-grade VUR were 64.7%, 69.9%, 33.3%, and 89.5%, respectively. Leukocytosis, elevated CRP, and prolonged fever (?#243;6 hours after treatment were significantly correlated with the cortical defects on DMSA scans and high-grade VUR. Conclusion : Clinical signs, including prolonged fever after treatment, elevated CRP, and leukocytosis, are positive predictors of acute pyelonephritis and high-grade VUR.

  15. The Effects of Childhood Abuse on Relationship Quality: Gender Differences and Clinical Implications

    Science.gov (United States)

    Larsen, Carly D.; Sandberg, Jonathan G.; Harper, James M.; Bean, Roy

    2011-01-01

    This study examined the relationship between self-reported childhood physical and sexual abuse, romantic relationship quality, possible gender differences, and clinical implications. Three hundred thirty-eight women and 296 men who sought services at a university mental health clinic in the northeast region of the United States completed a…

  16. Clinical practice guidelines and patient decision aids. An inevitable relationship.

    NARCIS (Netherlands)

    Weijden, T. van der; Boivin, A.; Burgers, J.S.; Schunemann, H.J.; Elwyn, G.

    2012-01-01

    As health professionals and patients are moving toward shared models of decision making, there is a growing need for integrated decision support tools that facilitate uptake of best evidence in routine clinical practice in a patient-centered manner. This article charts the landscape of clinical prac

  17. Developing more open and equitable relationships with industry to improve advancements in clinical research in dermatology.

    Science.gov (United States)

    Campa, M; Ryan, C; Menter, A

    2016-06-01

    Relationships between physicians, scientists, and the pharmaceutical industry can be complicated by conflicts of interest. Honest and equitable relationships, however, are essential to the advancement of dermatologic clinical research. Several factors can increase transparency in clinical trials including preregistration of clinical trials, reporting of all data produced from clinical trials, non-industry ownership of clinical trial data, clarity of statistical methods and publication of both positive and negative results. Through collaborative, scientifically rigorous studies, physicians and industry can achieve significant advances in dermatologic care. PMID:27317287

  18. Relationship between practice counselling and referral to outpatient psychiatry and clinical psychology.

    OpenAIRE

    Cape, J; Parham, A.

    1998-01-01

    BACKGROUND: Although reduction in the use of secondary care mental health services is a suggested benefit of counselling in general practice, there has been little empirical investigation of this relationship. AIM: To investigate the relationship between the provision of counselling in general practice and the use of outpatient psychiatry and clinical psychology services across a geographical area. METHOD: Information on referrals to outpatient psychiatry and clinical psychology from all gene...

  19. Relationship between Emotional Intelligence and Clinical Competencies of Nursing Students in Tabriz Nursing and Midwifery School

    Directory of Open Access Journals (Sweden)

    Rahkar Farshi Mahni

    2015-07-01

    Full Text Available Introduction: Preparing students to take over job responsibilities is one of the most challenging duties of nursing schools. The focus of nursing education should be on helping students to achieve high levels of competence in nursing care and identify factors for reinforcing it. Since desirable results have not been reported on clinical competencies of nursing students, achieving skills to control their emotions could be effective. Thus, this study aimed to investigate the relationship between emotional intelligence (EI and clinical competencies. Methods: In this correlational study, all nursing students in semesters 6, 7 and 8 were studied after determining the sample size in Tabriz University of Medical Sciences. The data were collected using three questionnaires of demographic data, the Emotional Intelligence Sharing – Sybrya and a short clinical competence. The data analysis was done through descriptive and inferential statistics using SPSS 18. Results: The results of the present study showed that the total EI score and clinical competence of students was more than moderate. The relationship between total EI and clinical competence was significant. Among the subscales of EI, there was a significant relationship between social skills and clinical competence. Conclusion: The relationship between the total emotional intelligence score and clinical competence of students in this study indicated the necessity and importance of emotions in decision-making to act properly within a clinical setting. Therefore, taking part in courses designed for learning skills of emotion perception and stress management in the workplace seem to be essential.

  20. Relationship between Genomic Types of Escherichia coli and Clinical Diseases

    Institute of Scientific and Technical Information of China (English)

    Meiying YI; Ruen LIU; Hanju HUANG

    2008-01-01

    In this study, by analysis of genome structures of E. coli, the relationships Between the genomic types of E. coli and the associated diseases were investigated. Samples of sputum, urine and other excretions from patients with different infective diseases were collected. And 62 E. coli strains were isolated from these samples. Intact bacterial genomic DNA was cleaved with I-CeuI, separated by pulsed field gel electrophoresis and then typed on the basis of cleavage map. The results showed that 7 I-CeuI sites were found in all the genome structures of the 62 E. coli, indicating that there were 7 rrn operons in the genomes. The size of genome ranged from 4500 kb to 5000 kb. According to thegenome structures, 62 E. coli strains were divided into 30 genome types. It was concluded that genome structures of E. coli isolated from the patients with different infective diseases varied to some extent, suggesting that some genome types of E. coli were closely related to some infective diseases.

  1. Relationship between oral clinical conditions and daily performances

    Directory of Open Access Journals (Sweden)

    Andréa Silveira Gomes

    2009-03-01

    Full Text Available The aim of this study was to assess the impact of oral status on the daily performances of civil servants from the Public Works and Waste Management Department of the city of Porto Alegre, located in Southern Brazil. A cross-sectional study was conducted on a representative sample composed of 276 civil servants with ages ranging from 35 to 44 years. The Oral Impacts on Daily Performances index developed was employed to measure impacts caused by oral clinical conditions. Oral examinations were performed after the interviews. Multinomial Logistic Regression Analysis was used. After adjusting for sex and educational level, the results showed that the subjects with high DMFT scores were 5.8 times (95% CI = 2.1-16.1 more likely to have high impacts on their everyday life than those with low DMFT scores. Subjects that presented some coronal caries were 4.3 times (95% CI = 1.9-9.8 more likely to have high impacts on their everyday life than those with no coronal caries. Dental status assessed through the DMFT index and coronal caries are important indicators of impacts on the everyday life of the studied population.

  2. Reflections on the supervised relationship and interaction in nursing clinical training

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    Inês Alves da Rocha e Silva Rocha

    2013-05-01

    Full Text Available This reflection fits into the area of Clinical Supervision in Nursing focusing on relationships that the student develops during clinical training. It seems that in clinical training the student not only learns but also consolidates verbal, procedural and attitudinal contents. The relationship established with peers, teachers and tutors will contribute to their professional identity. It is underlined the importance of the contribution of clinical supervision for the development of a reflective thinking in students in Portugal, as highlighted here, which influences the changes in nursing practices, as well as ensuring the quality and safety of the care provided. The characteristics that the tutor must have to improve the development of the students are also explained as well as the possible solutions for the existing limitations of clinical training contexts.

  3. Critical thinking and clinical competence: a study of their relationship in BSN seniors.

    Science.gov (United States)

    May, B A; Edell, V; Butell, S; Doughty, J; Langford, C

    1999-03-01

    National nursing organizations and nurses in the workplace identify critical thinking skills as essential to competent nursing practice. This study sets out to test the relationship between critical thinking skills and clinical competence because it seems that competent practice depends on critical thinking abilities. This study focuses on one school of nursing's response to the challenge of defining and measuring critical thinking and clinical competence and examining their relationship. An exploratory nonexperimental design was used with a heterogeneous sample consisting of two graduating nursing classes (N = 143). While the group of participants was able to think critically and practice competently according to set standards, there were no statistically significant correlations between critical thinking and clinical competence total scores. One conclusion for these findings is that critical thinking may not emerge as an associated factor with clinical competence until some time after nursing students become practicing nurses. PMID:10102507

  4. Prevalence of herpesviruses in gingivitis and chronic periodontitis: relationship to clinical parameters and effect of treatment

    OpenAIRE

    Rucha Shah; Dhoom Singh Mehta

    2016-01-01

    Background: Assess the prevalence of herpesviruses in healthy subjects, gingivitis, and chronic periodontitis patients, to assess the relationship between the prevalence of herpesviruses and periodontal clinical parameters, and to evaluate the effect of phase-I therapy on the level of viral detection. Materials and Methods: Hundred patients consisting of 20 healthy subjects, 40 gingivitis, and 40 chronic periodontitis were included in the study. Clinical parameters recorded included plaque in...

  5. Clinical and histopathological features and relationship of Barrett esophagus and its related adenocarcinoma

    Institute of Scientific and Technical Information of China (English)

    陈慧

    2014-01-01

    Objective To explore the clinical and histopathological features of Barrett esophagus and its related adenocarcinoma as well as the relationship between them.Methods From ajanuary 2002 to January 2012,the clinical data of 35 patients with Barrett esophagus,850 patients with esophagus cancer and 218 patients with esophageal-gastric junction cancer were collected,and the histopathological features of all the patients and the followup in patients with Barrett esophagus were retrospectively

  6. Some insights for a relationship marketing model integrating SERVQUAL and customer loyalty in dental clinics

    OpenAIRE

    Vargas Perez, Ana Maria; Grijalvo Martin, Maria Mercedes; Mercado Idoeta, Carmelo

    2012-01-01

    The demand of new services, the emergence of new business models, insufficient innovation, underestimation of customer loyalty and reluctance to adopt new management are evidence of the deficiencies and the lack of research about the relations between patients and dental clinics. In this article we propose the structure of a model of Relationship Marketing (RM) in the dental clinic that integrates information from SERVQUAL, Customer Loyalty (CL) and activities of RM and combines the vision of...

  7. An Inverse Relationship Between Ceramide Synthesis and Clinical Severity in Patients with Psoriasis

    OpenAIRE

    Cho, Yunhi; Lew, Bark-Lynn; Seong, Kyunghwa; Kim, Nack-In

    2004-01-01

    Ceramides play major roles in maintaining the epidermal barrier. It has been sus-pected that the depletion of ceramides, associated with disrupted barrier function in the epidermis, leads to the clinical manifestation of dryness and inflammation seen in patients with psoriasis. The aim of the present study was to determine the relation-ship between the level of ceramide synthesis in the epidermis and the clinical severity in patients with psoriasis. Samples from lesional and unlesional epider...

  8. Relationship between Angiographic Late Loss and 5-Year Clinical Outcome after Drug-Eluting Stent Implantation

    OpenAIRE

    Yang, Young-June; Shin, Sanghoon; Kim, Byeong-Keuk; Kim, Jung-Sun; Shin, Dong-Ho; Ko, Young-Guk; Choi, Donghoon; Jang, Yangsoo; Hong, Myeong-Ki

    2012-01-01

    Purpose Currently, insufficient data exist to evaluate the relationship between angiographic late loss (LL) and long-term clinical outcome after drug-eluting stent (DES) implantation. In this study, we hypothesized that angiographic LL between 0.3 and 0.6 mm correlate with favorable long-term clinical outcomes. Materials and Methods Patients were enrolled in the present study if they had undergone both DES implantation in single coronary vessel and a subsequent follow-up angiogram (n=634). Th...

  9. A systematic review of the relationship between blood loss and clinical signs.

    Directory of Open Access Journals (Sweden)

    Rodolfo Carvalho Pacagnella

    Full Text Available INTRODUCTION: This systematic review examines the relationship between blood loss and clinical signs and explores its use to trigger clinical interventions in the management of obstetric haemorrhage. METHODS: A systematic review of the literature was carried out using a comprehensive search strategy to identify studies presenting data on the relationship of clinical signs & symptoms and blood loss. Methodological quality was assessed using the STROBE checklist and the general guidelines of MOOSE. RESULTS: 30 studies were included and five were performed in women with pregnancy-related haemorrhage (other studies were carried in non-obstetric populations. Heart rate (HR, systolic blood pressure (SBP and shock index were the parameters most frequently studied. An association between blood loss and HR changes was observed in 22 out of 24 studies, and between blood loss and SBP was observed in 17 out of 23 studies. An association was found in all papers reporting on the relationship of shock index and blood loss. Seven studies have used Receiver Operating Characteristic Curves to determine the accuracy of clinical signs in predicting blood loss. In those studies the AUC ranged from 0.56 to 0.74 for HR, from 0.56 to 0.79 for SBP and from 0.77 to 0.84 for shock index. In some studies, HR, SBP and shock index were associated with increased mortality. CONCLUSION: We found a substantial variability in the relationship between blood loss and clinical signs, making it difficult to establish specific cut-off points for clinical signs that could be used as triggers for clinical interventions. However, the shock index can be an accurate indicator of compensatory changes in the cardiovascular system due to blood loss. Considering that most of the evidence included in this systematic review is derived from studies in non-obstetric populations, further research on the use of the shock index in obstetric populations is needed.

  10. A Qualitative Study of School Social Workers' Clinical and Professional Relationships when Reporting Child Maltreatment

    Science.gov (United States)

    Chanmugam, Amy

    2009-01-01

    This qualitative study explored school social workers' relationships during instances of abuse and neglect reporting, focusing on reports made for children and adolescents already receiving school social work services. Although school social workers frequently file abuse and neglect reports, little is known about how they manage clinical and…

  11. Relationship between somatic cell count status and subsequent clinical mastitis in Dutch dairy cows

    NARCIS (Netherlands)

    Borne, van den B.H.P.; Vernooij, J.C.M.; Lupindu, A.M.; Schaik, van G.; Frankena, K.; Lam, T.J.G.M.; Nielen, M.

    2011-01-01

    High composite somatic cell counts (CSCC) in dairy cows may develop into clinical mastitis (CM), suggesting that prevention or intervention of high CSCC may prevent CM later in lactation. The objective of this study was to quantify the relationship between high CSCC in dairy cows and the first subse

  12. Relationship between cognition, clinical and cognitive insight in psychotic disorders : A review and meta-analysis

    NARCIS (Netherlands)

    Nair, Akshay; Palmer, Emma Claire; Aleman, Andre; David, Anthony S.

    2014-01-01

    The neurocognitive theory of insight posits that poor insight in psychotic illnesses is related to cognitive deficits in cognitive self-appraisal mechanisms. In this paper we perform a comprehensive meta-analysis examining relationships between clinical insight and neurocognition in psychotic disord

  13. The relationship between nurses’ clinical competence and burnout in neonatal intensive care units

    Science.gov (United States)

    Soroush, Fatemehzahra; Zargham-Boroujeni, Ali; Namnabati, Mahboobeh

    2016-01-01

    Background: Nurses’ clinical competency plays an important role in the care of preterm infants. On the other hand, burnout is one of the most important factors in reducing the nurses’ efficiency. With regard to the importance of the role of nurses, and the vulnerability of the infants, the purpose of this study was to investigate the relationship between nurses’ burnout and clinical competency in NICUs. Materials and Methods: The descriptive cross-sectional study was conducted with the participation of 86 nurses working in the NICUs of hospitals in Isfahan, Iran. Census sampling method was used in the NICUs of educational hospitals in 2014. Data were collected by a questionnaire including demographic characteristics, Patricia clinical competency, and Maslach burnout scales. Data were analyzed by the statistical tests of independent t-test and Pearson correlations test with the significance level of α burnout were assessed at three levels (weak, moderate, and strong levels). Statistical tests showed that clinical competency was at a moderate level in all fields. Of the dimensions of nurses’ burnout, emotional exhaustion was moderate, depersonalization was weak, and personal performance was strong. The results showed that nurses’ burnout and clinical competency in the NICUs were at a moderate level and had a significant negative relationship (r = −0.322, P = 0.003). Conclusions: Results showed that burnout had a negative relationship with competency. Therefore, managers are suggested to improve nurses’ competency and diminish their job burnout through better and more applicable planning. PMID:27563328

  14. Relationship between clinical findings of temporomandibular disorders and magnetic resonance imaging

    International Nuclear Information System (INIS)

    The present study was conducted to investigate the relationship between magnetic resonance imaging (MRI) of the temporomandibular joint (TMJ) and clinical findings of patients having symptoms of temporomandibular disorders, and to consider the possibility to grasp the internal derangement of the TMJ from clinical findings. Subjects were 80 patients who visited to ask orthodontic treatment 16 males and 64 females. The average age was 22 years and 4 months. We performed a investigation of both their previous and present illness. In addition, to decide the correct condition concerning the internal derangement of the TMJ, patients were given MRI examinations (G. E. medical system Signa 1.5 Tesla) before orthodontic treatment. Results were as follows: The three symptoms of temporomandibular disorders-noise, pain, and abnormal mandibular movement, were not related to constant disk displacement. It seemed difficult to infer and obtain the diagnosis of the condition of internal derangement of the TMJ only from clinical findings. In a dental clinics having no medical imaging instrument such as MRI, it was, however, considered that the following items will make it possible to define the condition of internal derangements of the TMJ from clinical findings. As to respects concerning clinical findings, it is necessary to consider the previous illness as well as present illness. TMJ noise indicates a higher relationship to the disk displacement in MRI findings. The temporomandibular joint with plural symptoms indicated a higher incidence of disk displacement examined by MR Imaging than that with a single symptom. (author)

  15. The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms.

    Science.gov (United States)

    Andrade, Jason; Khairy, Paul; Dobrev, Dobromir; Nattel, Stanley

    2014-04-25

    Atrial fibrillation (AF) is the most common arrhythmia (estimated lifetime risk, 22%-26%). The aim of this article is to review the clinical epidemiological features of AF and to relate them to underlying mechanisms. Long-established risk factors for AF include aging, male sex, hypertension, valve disease, left ventricular dysfunction, obesity, and alcohol consumption. Emerging risk factors include prehypertension, increased pulse pressure, obstructive sleep apnea, high-level physical training, diastolic dysfunction, predisposing gene variants, hypertrophic cardiomyopathy, and congenital heart disease. Potential risk factors are coronary artery disease, kidney disease, systemic inflammation, pericardial fat, and tobacco use. AF has substantial population health consequences, including impaired quality of life, increased hospitalization rates, stroke occurrence, and increased medical costs. The pathophysiology of AF centers around 4 general types of disturbances that promote ectopic firing and reentrant mechanisms, and include the following: (1) ion channel dysfunction, (2) Ca(2+)-handling abnormalities, (3) structural remodeling, and (4) autonomic neural dysregulation. Aging, hypertension, valve disease, heart failure, myocardial infarction, obesity, smoking, diabetes mellitus, thyroid dysfunction, and endurance exercise training all cause structural remodeling. Heart failure and prior atrial infarction also cause Ca(2+)-handling abnormalities that lead to focal ectopic firing via delayed afterdepolarizations/triggered activity. Neural dysregulation is central to atrial arrhythmogenesis associated with endurance exercise training and occlusive coronary artery disease. Monogenic causes of AF typically promote the arrhythmia via ion channel dysfunction, but the mechanisms of the more common polygenic risk factors are still poorly understood and under intense investigation. Better recognition of the clinical epidemiology of AF, as well as an improved appreciation of

  16. The relationship between attachment styles and internalizing or externalizing symptoms in clinical and nonclinical adolescents

    Directory of Open Access Journals (Sweden)

    Fernando Lacasa

    2015-05-01

    Full Text Available Studies regarding the relationship between attachment and psychopathology during adolescence have been performed separately for clinical and nonclinical adolescents and have used different assessment measures, which together might produce a methodological bias that increases the association between attachment and psychopathology. With the aim of avoiding this bias, the present study used identical measures to explore the relationship between attachment styles and internalizing or externalizing symptoms in clinical and nonclinical samples of adolescents. The sample consisted of 258 adolescents, 129 clinical and 129 nonclinical, aged between 14 and 18 years. The adolescents in each sample were matched for age, gender, and socioeconomic status. Attachment was assessed using the CaMir Q-sort, and psychopathological symptoms were assessed by means of the Youth Self Report (YSR. The relationships between attachment and psychopathology were similar for clinical and nonclinical adolescents. A preoccupied attachment style predicted internalizing and externalizing symptoms, somatic complaints, anxious-fearful behavior, verbal aggression, attention-seeking behavior, and thinking problems. Compared to previous studies, this research has made it possible to identify broader, stronger, and more specific associations between preoccupied attachment style and psychopathological symptoms in adolescents.

  17. Quantitative Evaluation of the Pivot Shift - Relationship to Clinical Pivot Shift Grade

    OpenAIRE

    Hoshino, Yuichi; Musahl, Volker; Irrgang, James J.; Lopomo, Nicola; Zaffagnini, Stefano; Karlsson,Jon; Kuroda, Ryosuke; Fu, Freddie H.

    2015-01-01

    Objectives: The rotational laxity, or the pivot shift test, is a key to understanding the anterior cruciate ligament (ACL) function after the ACL injury and reconstruction. Various measurement methods have been developed to quantify the pivot shift test, but the clinical implications of the measurement results have not been established mainly because of a wide variability of the pivot shift test between examiners. The purpose of this study was to determine the relationship between quantitativ...

  18. Relationship between Emotional Intelligence and Clinical Competencies of Nursing Students in Tabriz Nursing and Midwifery School

    OpenAIRE

    Rahkar Farshi Mahni; Vahidi Maryam; Jabraeili Mahnaz

    2015-01-01

    Introduction: Preparing students to take over job responsibilities is one of the most challenging duties of nursing schools. The focus of nursing education should be on helping students to achieve high levels of competence in nursing care and identify factors for reinforcing it. Since desirable results have not been reported on clinical competencies of nursing students, achieving skills to control their emotions could be effective. Thus, this study aimed to investigate the relationship betwee...

  19. Exploration of the relationship between self-compassion, alexithymia and emotion regulation in a clinical population.

    OpenAIRE

    Rusk, Dorothy Alice

    2015-01-01

    Background: Negative forms of self-relating such as self-criticism and self-judgement are known to contribute to poor mental health across diagnoses including eating disorders. Negative self-relating can lead to avoidance or suppression of emotions, and poor attachment relationships can lead to deficits in self-reassuring abilities. Self-compassion is a construct which is gaining attention in clinical research as a potentially important and healthy way of relating to the self i...

  20. What is the relationship between emotional intelligence and dental student clinical performance?

    Science.gov (United States)

    Victoroff, Kristin Zakariasen; Boyatzis, Richard E

    2013-04-01

    Emotional intelligence has emerged as a key factor in differentiating average from outstanding performers in managerial and leadership positions across multiple business settings, but relatively few studies have examined the role of emotional intelligence in the health care professions. The purpose of this study was to examine the relationship between emotional intelligence (EI) and dental student clinical performance. All third- and fourth-year students at a single U.S. dental school were invited to participate. Participation rate was 74 percent (100/136). Dental students' EI was assessed using the Emotional Competence Inventory-University version (ECI-U), a seventy-two-item, 360-degree questionnaire completed by both self and other raters. The ECI-U measured twenty-two EI competencies grouped into four clusters (Self-Awareness, Self-Management, Social Awareness, and Relationship Management). Clinical performance was assessed using the mean grade assigned by clinical preceptors. This grade represents an overall assessment of a student's clinical performance including diagnostic and treatment planning skills, time utilization, preparation and organization, fundamental knowledge, technical skills, self-evaluation, professionalism, and patient management. Additional variables were didactic grade point average (GPA) in Years 1 and 2, preclinical GPA in Years 1 and 2, Dental Admission Test academic average and Perceptual Ability Test scores, year of study, age, and gender. Multiple linear regression analyses were conducted. The Self-Management cluster of competencies (b=0.448, p<0.05) and preclinical GPA (b=0.317, p<0.01) were significantly correlated with mean clinical grade. The Self-Management competencies were emotional self-control, achievement orientation, initiative, trustworthiness, conscientiousness, adaptability, and optimism. In this sample, dental students' EI competencies related to Self-Management were significant predictors of mean clinical grade

  1. Relationship between radiological grading and clinical status in knee osteoarthritis. a multicentric study

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    Hernández-Vaquero Daniel

    2012-10-01

    Full Text Available Abstract Background Controversy exists regarding the relationship between radiographic findings and clinical status in knee osteoarthritis. Although the surgical indication for total knee arthroplasty (TKA should be based on pain, clinical status, and the deterioration of quality of life, the radiographic study is the most commonly used criterion for preoperative evaluation. The objective of this study is to find out the relationship between the Ahlbäck classification and clinical status in patients undergoing TKA. Methods 1329 protocols were collected from preoperative studies in four multicentric working groups (the Interax, Duracon, Scorpio, and Triathlon Spanish groups in 30 Spanish hospitals. Mean age was 70.4 years (SD: 6.8; range: 35 to 98; 76.3% of patients were women. Patients entered the study whenever the surgeon found that medical treatment was insufficient to control pain and functional limitation. Data were collected using electronic Case Report Forms, and included Ahlbäck grading scores, Hospital for Special Surgery Knee Score (HSS, SF-12, and other clinical and epidemiologic variables. Results According to the Ahlbäck grading system, patients were divided as follows: 243 grade I (18.3%, 358 grade II (26.9%, 416 grade III (31.3%, 241 grade IV (18.1%, and 71 grade V (5.3%. As for HSS, the following scores were obtained: Conclusions We found a relationship between Ahlbäck grading and the preoperative clinical score. The range of variability of the HSS score between the different Ahlbäck grades is small.

  2. Attachment style and its relationship to working alliance in the supervision of British clinical psychology trainees.

    Science.gov (United States)

    Dickson, Joanne M; Moberly, Nicholas J; Marshall, Yehuda; Reilly, James

    2011-01-01

    Although the supervisory relationship is thought to be critical in training clinical psychologists, little is known about factors affecting the supervisory alliance. We conducted an Internet survey of British clinical doctoral trainees (N = 259) in which participants rated their supervisory working alliance, parental style during childhood, pathological adult attachment behaviours and attachment style for themselves and their supervisors. Trainees' ratings of the working alliance were associated with perceptions of supervisors' attachment style, but not with perceptions of trainees' own attachment styles. Path analysis supported a causal chain linking parental indifference, compulsive self-reliance, insecure supervisor attachment style and lower ratings of the working alliance. Our results broadly replicate data from a US sample and suggest that attachment theory is helpful in understanding clinical supervisory processes.

  3. The Relationship between Immediate Relevant Basic Science Knowledge and Clinical Knowledge: Physiology Knowledge and Transthoracic Echocardiography Image Interpretation

    Science.gov (United States)

    Nielsen, Dorte Guldbrand; Gotzsche, Ole; Sonne, Ole; Eika, Berit

    2012-01-01

    Two major views on the relationship between basic science knowledge and clinical knowledge stand out; the Two-world view seeing basic science and clinical science as two separate knowledge bases and the encapsulated knowledge view stating that basic science knowledge plays an overt role being encapsulated in the clinical knowledge. However, resent…

  4. What is the relationship between emotional intelligence and dental student clinical performance?

    Science.gov (United States)

    Victoroff, Kristin Zakariasen; Boyatzis, Richard E

    2013-04-01

    Emotional intelligence has emerged as a key factor in differentiating average from outstanding performers in managerial and leadership positions across multiple business settings, but relatively few studies have examined the role of emotional intelligence in the health care professions. The purpose of this study was to examine the relationship between emotional intelligence (EI) and dental student clinical performance. All third- and fourth-year students at a single U.S. dental school were invited to participate. Participation rate was 74 percent (100/136). Dental students' EI was assessed using the Emotional Competence Inventory-University version (ECI-U), a seventy-two-item, 360-degree questionnaire completed by both self and other raters. The ECI-U measured twenty-two EI competencies grouped into four clusters (Self-Awareness, Self-Management, Social Awareness, and Relationship Management). Clinical performance was assessed using the mean grade assigned by clinical preceptors. This grade represents an overall assessment of a student's clinical performance including diagnostic and treatment planning skills, time utilization, preparation and organization, fundamental knowledge, technical skills, self-evaluation, professionalism, and patient management. Additional variables were didactic grade point average (GPA) in Years 1 and 2, preclinical GPA in Years 1 and 2, Dental Admission Test academic average and Perceptual Ability Test scores, year of study, age, and gender. Multiple linear regression analyses were conducted. The Self-Management cluster of competencies (b=0.448, pemotional self-control, achievement orientation, initiative, trustworthiness, conscientiousness, adaptability, and optimism. In this sample, dental students' EI competencies related to Self-Management were significant predictors of mean clinical grade assigned by preceptors. Emotional intelligence may be an important predictor of clinical performance, which has important implications for

  5. Psychosocial function in schizophrenia and bipolar disorder: Relationship to neurocognition and clinical symptoms.

    Science.gov (United States)

    Simonsen, Carmen; Sundet, Kjetil; Vaskinn, Anja; Ueland, Torill; Romm, Kristin Lie; Hellvin, Tone; Melle, Ingrid; Friis, Svein; Andreassen, Ole A

    2010-09-01

    In line with a dimensional approach to psychopathology, we examined whether psychosocial function and its relationship to neurocognition and clinical symptoms differ across schizophrenia and bipolar disorder subgroups with and without a history of affective or psychotic episodes. From the TOP study, a heterogeneous sample of individuals with schizophrenia spectrum disorders without (n = 60) and with a history of affective episodes (n = 54); individuals with bipolar spectrum disorders with (n = 64) and without a history of psychosis (n = 56) and healthy controls (n = 268) participated. Psychosocial functioning was measured with the Social Functioning Scale (self-rated) and the Global Assessment of Functioning Scale (clinician-rated), neurocognition with a comprehensive neuropsychological test battery, and symptoms with Inventory of Depressive Symptomatology, Young Mania Rating Scale, and Positive and Negative Syndrome Scale. Clinician-rated functioning was poorer in schizophrenia groups than in bipolar groups, but self-rated functioning was similar across all clinical groups and poorer than in controls. Neurocognition and current clinical symptoms were associated with psychosocial function in bivariate analyses, but current symptoms had a greater independent contribution to functioning than neurocognition across clinical groups in multivariate analyses. Despite differences in neurocognition and psychosocial function, groups showed the same pattern in prediction of functioning irrespective of DSM-IV or clinical definition. PMID:20509984

  6. Structural and biomechanical aspects of equine sacroiliac joint function and their relationship to clinical disease.

    Science.gov (United States)

    Goff, L M; Jeffcott, L B; Jasiewicz, J; McGowan, C M

    2008-06-01

    Pain originating from the sacroiliac joint (SIJ) in horses has long been associated with poor performance, yet specific diagnosis of sacroiliac dysfunction (SID) has been difficult to achieve. Clinical presentation of SID appears to fall into two categories. The first, presenting as pain and poor performance, is responsive to local analgesia of periarticular structures with poorly defined pathology. The second presents primarily as poor performance with bony pathological changes as a result of chronic instability. Diagnostic tests based on biomechanics as well as manual provocation for SIJ pain have formed the basis of tests currently used to diagnose SIJ dysfunction in humans. This review summarises the anatomy and biomechanics of the equine SIJ and current biomechanical, innervation and motor control concepts in human SID. The relationship between abnormal SIJ motion and altered neuromotor control with clinical disease of the equine SIJ are discussed. Future utilisation of these principles to develop new diagnostic and management tools for the equine SID is promising. PMID:17493851

  7. Structural and biomechanical aspects of equine sacroiliac joint function and their relationship to clinical disease.

    Science.gov (United States)

    Goff, L M; Jeffcott, L B; Jasiewicz, J; McGowan, C M

    2008-06-01

    Pain originating from the sacroiliac joint (SIJ) in horses has long been associated with poor performance, yet specific diagnosis of sacroiliac dysfunction (SID) has been difficult to achieve. Clinical presentation of SID appears to fall into two categories. The first, presenting as pain and poor performance, is responsive to local analgesia of periarticular structures with poorly defined pathology. The second presents primarily as poor performance with bony pathological changes as a result of chronic instability. Diagnostic tests based on biomechanics as well as manual provocation for SIJ pain have formed the basis of tests currently used to diagnose SIJ dysfunction in humans. This review summarises the anatomy and biomechanics of the equine SIJ and current biomechanical, innervation and motor control concepts in human SID. The relationship between abnormal SIJ motion and altered neuromotor control with clinical disease of the equine SIJ are discussed. Future utilisation of these principles to develop new diagnostic and management tools for the equine SID is promising.

  8. Relationship between serial CT findings and clinical course of purulent meningitis

    Energy Technology Data Exchange (ETDEWEB)

    Nakata, Mihoko; Nakata, Hajime; Kawanami, Takashi; Fukuda, Miho

    1984-11-01

    We reviewed the CT examinations and clinical records of 31 patients of purulent meningitis to evaluate the relation of CT findings to pathogenic bacteria and clinical course. The most frequently observed abnormal CT finding was an enlargement of the subarachnoid space and ventricles. There was no relationship between those abnormal CT findings and pathogenic bacteria. Enlargement of ventricles, low density area of the white matter and subdural effusion suggested the necessity of the surgical treatment or poor prognosis. The patients with convulsion or re-elevation of CRP had a tendency to show an exacerbation of such abnormalities. On the contrary, abnormal CT findings improved in the patients without convulsion or with decrease of CRP. We conclude that a follow-up CT examination is indicated in cases developing convulsion or re-elevation of CRP. (author).

  9. The Relationship between Clinical and Chemical Hyperandrogenism in 14-18-Years- Old Girls

    Directory of Open Access Journals (Sweden)

    Tahereh Naderi

    2012-04-01

    Full Text Available Background: One of the most common endocrine disorders in women's medicine is the increased androgen and the symptoms of increased androgens in women such as polycystic ovary syndrome. The two main components to diagnose this syndrome are menstrual disorder and clinical or laboratory hyperandrogenism, but other causes should be ruled out in order to confirm the diagnosis. This study aims to examine clinical Hyperandrogenism in female students of 14 to 18 years old in Shiraz in 2010.Materials and Methods: This cross-sectional study was conducted on 3200 female high school students of 14-18 years old in Shiraz. Data collection tools include questionnaires containing personal details, clinical Hyperandrogenism features (acne, alopecia and hirsutism based on Freeman-Galway scale and test results. The ultrasound was conducted based on Adams criteria. The data results are analyzed using SPSS-15 software and χ2 and t statistical tests.Results: : In this study, the frequency of hirsutism is 3.2%, prevalence of acne is 5% and alopecia is 4.2%. Mean of free testosterone (1.647±0.835 was higher in the group with hirsutism, acne and alopecia. Independent t-test showed no significant relationship between patients with hirsutism, acne and alopecia and non-affected people in terms of mean of total testosterone and free testosterone. However, there is a significant relationship between people with acne and hirsutism and polycystic ovary compared with those with acne and hirsutism and those without polycystic ovary (p >0.05..Conclusion: This study indicated that clinical and chemical hyperandrogenism can be a criterion to diagnose with polycystic ovary syndrome, but ultrasound was not helpful.

  10. A survey on relationships between thyroid hormone levels and clinical findings in dairy calf diarrhea

    Directory of Open Access Journals (Sweden)

    Ali Hajimohammadi

    2015-03-01

    Full Text Available Calf diarrhea is an important disease that occurs in association with the interaction of various infectious agents and calf susceptibility. The economic losses is associated with death loss and treatment costs, reduction of live weight gain, and reduction of productive life span, which may be considerable. Thyroid hormones previously thought mainly in thermoregulation and energy metabolism. Recently, several studies have challenged on their roles in the metabolic response of animals to certain conditions such as nutritional, environmental, or disease state. The aim of the present study was to survey relationships between thyroid hormones in calves with diarrhea in the different clinical features. Holstein calves (50 within 1 day to 2 months old with signs of diarrhea and healthy calves (40 with similar age and sex were selected. Standard clinical examinations and also dehydration degree assessment were carried out on each calf and recorded accordingly. Calves with clinical signs of diarrhea were divided in different groups based on the severity of the clinical findings, fever and degree of dehydration. Blood samples were taken from the jugular vein from all calves into vacutainer tubes for serum collection.T4, fT4, T3 and fT3 concentrations were measured by validated methods. A significant increase in T4, T3 and fT3 in diarrheic calves was observed (P<0.05. Thyroid hormones in calves with severe clinical signs decreased significantly (P<0.001 compared to calves with moderate or mild systemic clinical signs. Thyroid hormones between febrile diarrheic calves compared to afebrile diarrheic calves had no significant changes. Diarrheic calves with severe dehydration compared to diarrheic calves with mild and moderate dehydration had significant decreases in their thyroid hormones (P<0.001.

  11. Relationship between clinical and pathologic findings in patients with chronic liver diseases

    Institute of Scientific and Technical Information of China (English)

    Lun-Gen Lu; Jun Ye; Xiong Cai; Cheng-Wei Chen; Ji-Yao Wang; Shan-Ming Wu; Jin-Shui Zhu; Xia-Qiu Zhou; Min-De Zeng; Yi-Min Mao; Ji-Qiang Li; De-Kai Qiu; Jing-Yuan Fang; Ai-Ping Cao; Mo-Bin Wan; Cheng-Zhong Li

    2003-01-01

    AIM: To explore the relationship between clinical findings of patients with chronic liver diseases and the pathologic grading and staging of liver tissues.METHODS: The inflammatory activity and fibrosis of consecutive liver biopsies from 200 patients were determined according to the diagnosis criteria of chronic hepatitis in China established in 1995. A comparative analysis was carried out for 200 patients with chronic liver diseases by comparing their clinical manifestations, serum biochemical markers with the grading and staging of liver tissues.RESULTS: It was revealed that age, index of clinical symptoms and physical signs were obviously relevant to the pathologic grading and staging of liver tissues (P<0.05). Blood platelet, red blood cells, aspartate aminotransferase (AST),N-terminal procollagen Ⅲ (PⅢ NP) were apparently correlated with the degree of inflammation. PGA (prothrombin time,GGT, apoprotein A1) index, PGAA (PGA+△2-macroglobublin)index, albumin and albumin/globulin were relevant to both inflammation and fibrosis. Hyaluronic acid (HA) was an accurate variable for the severity of hepatic inflammation and fibrosis. The combination of serum markers for fibrosis could increase the diagnostic accuracy. It was notable that viral replication markers were not relevant to the degree of inflammation and fibrosis.CONCLUSION: There is a good correlation between clinical findings and the pathologic grading and staging of liver tissues, which may give aid to the noninvasive diagnosis of liver fibrosis.

  12. The relationships between initial clinical features and prognosis in 14 cases of diffuse alveolar hemorrhage syndrome

    International Nuclear Information System (INIS)

    Diffuse pulmonary alveolar hemorrhage (DAH) is caused by various disorders and is a medical emergency that often results in acute respiratory failure requiring prompt diagnosis and aggressive treatment. However, the relationships between the prognosis and the initial clinical feature in DAH remain unclear. We investigated the relationships between initial clinical features and prognosis in 14 cases of DAH. We examined 14 patients with DAH about laboratory data, CT scan findings, treatment and outcome. Three of 14 patients died of acute respiratory failure due to DAH. In the laboratory data on admission, the patients with over 230 IU/L of serum lactate dehydrogenase (LDH) levels had a poor outcome. In pulmonary function data on admission, the patients with under 300 of PaO2/FiO2 (P/F) ratio had poor outcome. On CT scan findings on admission, the patients with consolidation shadows had a poor outcome compared to the patients with ground-glass shadows. In our data, serum LDH concentration, P/F ratio and CT scan findings on admission are important factors in the prognosis of DAH. (author)

  13. Relationship between ABO blood groups and malaria with clinical outcome in rural area of South India

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    Gayathri B.N.

    2013-05-01

    Full Text Available Background A number of studies have shown that susceptibility to several infectious diseases is related to the patient’s blood group. Although the relationship between blood group and susceptibility to malaria has been studied by several researchers, the results have been contradictory. Since malaria has re-emerged as a major problem in India during the past few years, it would be useful to know whether there is any relationship between blood group and infection. Objectives The study will be undertaken to correlate the blood groups and clinical presentations in malaria patients and to understand the differential host susceptibility in malaria. Method Over a period of 4 years malaria positive samples identified by peripheral smear (thin and thick smears will be evaluated in this study. Haemoglobin, total leucocyte count, differential leucocyte count and platelet count of each patient done on an automated cell counter will be retrieved from the data. Blood group was determined by forward and reverse method. The demographic details of the patients and clinical details were obtained from case records of the patients. Malarial species and the severity of clinical course were correlated with blood groups Results A total of 205 patients were included in the study, of which 123 cases were positive for plasmodium falciparum and 78 cases were positive for P. vivax infection and 4 patients had mixed infection. The results of blood groups showed 33 -‘A’ group, 84 -‘B’ group, 70 -‘O’ group and 18 were ‘AB’ group. When the clinical courses between different groups were compared using the following parameters for severe infection- a parasitic load of > 10/1000 RBCs, severe anemia with haemoglobin 101o F and the other organ involvement, it was observed that there was no significant relationship between ABO blood group and malaria in our population, this could be due to various demographic reasons. Conclusions The present study indicate that

  14. Severe visceral leishmaniasis in children: the relationship between cytokine patterns and clinical features

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    Monica Elinor Alves Gama

    2013-12-01

    Full Text Available Introduction The relationship between severe clinical manifestations of visceral leishmaniasis (VL and immune response profiles has not yet been clarified, despite numerous studies on the subject. This study aimed to investigate the relationship between cytokine profiles and the presence of immunological markers associated with clinical manifestations and, particularly, signs of severity, as defined in a protocol drafted by the Ministry of Health (Brazil. Methods We conducted a prospective, descriptive study between May 2008 and December 2009. This study was based on an assessment of all pediatric patients with VL who were observed in a reference hospital in Maranhão. Results Among 27 children, 55.5% presented with more than one sign of severity or warning sign. Patients without signs of severity or warning signs and patients with only one warning sign had the highest interferon-gamma (IFN-γ levels, although their interleukin 10 (IL-10 levels were also elevated. In contrast, patients with the features of severe disease had the lowest IFN-γ levels. Three patients who presented with more than two signs of severe disease died; these patients had undetectable interleukin 2 (IL-2 and IFN-γ levels and low IL-10 levels, which varied between 0 and 36.8pg/mL. Conclusions Our results showed that disease severity was associated with low IFN-γ levels and elevated IL-10 levels. However, further studies with larger samples are needed to better characterize the relationship between disease severity and cytokine levels, with the aim of identifying immunological markers of active-disease severity.

  15. The relationships between preoperative urodynamic parameters and clinical outcomes in urinary stress incontinence

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    Yaşar Bozkurt

    2008-12-01

    Full Text Available The aim of present study was to evaluate the influence of urodynamic parameters on preoperative and postoperative clinical pictures in stress incontinence.Charts of patients, who were operated for stress incontinence using autologous rectus fascia sling between March 1999 and January 2005 in Tepecik Training and Research Hospital Urology Clinic, were evaluated retrospectively.A total of 41 patients were divided into two subgroups as, pure (10 patients and mixed stress incontinence (31 patients groups. Mean age of patients was 50.4 (33-70 years. Fifteen patients had intrinsic sphincter insufficiency (ISI. Mixed incontinence group had lower volume for first sensation and more detrusor overactivity than pure group. ISI did not alter the success of operation. Urodynamically no relationship was found between detrusor pressure and postoperative postvoiding residual urine (P>0.05.In conclusion, urodynamic evaluation before surgery was not related to preoperative and postoperative clinical picture of patients, but first sensation of bladder is only predictive for the success in fascial sling surgery.

  16. Prevalence of herpesviruses in gingivitis and chronic periodontitis: relationship to clinical parameters and effect of treatment

    Directory of Open Access Journals (Sweden)

    Rucha Shah

    2016-01-01

    Full Text Available Background: Assess the prevalence of herpesviruses in healthy subjects, gingivitis, and chronic periodontitis patients, to assess the relationship between the prevalence of herpesviruses and periodontal clinical parameters, and to evaluate the effect of phase-I therapy on the level of viral detection. Materials and Methods: Hundred patients consisting of 20 healthy subjects, 40 gingivitis, and 40 chronic periodontitis were included in the study. Clinical parameters recorded included plaque index, gingival index, sulcus bleeding index, probing depth, and clinical attachment level. The gingivitis and chronic periodontitis patients received phase-I periodontal therapy including oral hygiene instructions, full mouth scaling for gingivitis patients and scaling and root planing for chronic periodontitis patients. Gingival crevicular fluid (GCF was collected, and the presence of herpes simplex virus-1 (HSV-1, HSV-2, cytomegalovirus, and Epstein–Barr virus (EBV was analyzed using polymerase chain reaction (PCR. Recording of periodontal parameters as well as GCF collection was performed at baseline and 6 weeks postphase-I therapy. Results: At baseline, the levels of HSV-1 and EBV detection were lower in healthy controls as compared to gingivitis (P < 0.05 and chronic periodontitis cases (P < 0.001. Phase-I therapy led to reduction in the amount of HSV-1 and EBV in gingivitis patients (P < 0.05 and for HSV-1, human cytomegalovirus and EBV in chronic periodontitis patients (P < 0.05 in comparison to baseline. The prevalence of EBV in chronic periodontitis patients was positively associated with increased gingival index, probing depth and loss of clinical attachment (P < 0.05. Conclusions: Higher prevalence of HSV-1 and EBV viruses in GCF of gingivitis and chronic periodontitis suggests a strong association between these viruses and periodontal diseases and periodontal therapy can lead to a reduction in herpesviruses at infected sites.

  17. Association of Clinical Researchers and Educators a statement on relationships between physicians and industry.

    Science.gov (United States)

    Weber, Michael A; Black, Henry R; Fonseca, Rafael; Garber, Jeffrey; Gonzalez-Campoy, J Michael; Kimmelstiel, Carey; Markowitz, Avi B; Nakayama, Don; Stell, Lance K; Stossel, Thomas P

    2012-01-01

    Collaborations between physicians, particularly those in academic medicine, and industries that develop pharmaceutical products, medical devices, and diagnostic tests have led to substantial advances in patient care. At the same time, there is a strong awareness that these relationships, however beneficial they may be, should conform to established principles of ethical professional practice. Through a writing committee drawn from diverse disciplines across several institutions, the Association of Clinical Researchers and Educators (ACRE) has written a code of conduct to provide guidance to physicians in observing these principles. Our recommendations are not intended to be prescriptive or inflexible, but rather to be of assistance to physicians in making their own personal decisions on whether, or how, to be involved in research, education, or other collaborations with industry. PMID:22982801

  18. Relationship between ultrasound elastography and myofibroblast distribution in breast cancer and its clinical significance.

    Science.gov (United States)

    Hao, Yi; Guo, Xia; Ma, Binlin; Zhu, Lin; Liu, Lisha

    2016-01-01

    The study investigated the relationship between ultrasound elastography (USE) scoring and myofibroblast distribution with expression features of α-SMA +/CD34- in patients of Uyghur and Han ethnicities with breast masses in Xinjiang, China. The data was used to evaluate its clinical significance in the early diagnosis of breast cancer. A total of 300 patients with breast masses were included in the study, which involved conventional sonography and USE, with histopathologic diagnosis as the reference standard. Myofibroblast distribution was investigated by detecting the expression levels of α-SMA and CD34 in lesions using immunohistochemistry and real-time PCR. Out of 300 lesions, 185 were histologically malignant and 115 benign. The mean elasticity score for malignant lesions was significantly higher than for benign lesions. The expression level of α-SMA was elevated while the expression level of CD34 was lower in malignancies, compared with benign lesions. The expression of α-SMA was positively associated with the USE scores, while a negative relationship was observed between CD34 expression and USE scoring. The combination of USE and molecular diagnosis provides a promising modality for the early diagnosis and evaluation of the risks in particular types of breast cancer. PMID:26846996

  19. Relationship of Cognition to Clinical Response in First-Episode Schizophrenia Spectrum Disorders.

    Science.gov (United States)

    Trampush, Joey W; Lencz, Todd; DeRosse, Pamela; John, Majnu; Gallego, Juan A; Petrides, Georgios; Hassoun, Youssef; Zhang, Jian-Ping; Addington, Jean; Kellner, Charles H; Tohen, Mauricio; Burdick, Katherine E; Goldberg, Terry E; Kane, John M; Robinson, Delbert G; Malhotra, Anil K

    2015-11-01

    First-episode schizophrenia (FES) spectrum disorders are associated with pronounced cognitive dysfunction across all domains. However, less is known about the course of cognitive functioning, following the first presentation of psychosis, and the relationship of cognition to clinical course during initial treatment. The present longitudinal study examined the magnitude of neurocognitive impairment, using the MATRICS Consensus Cognitive Battery, in patients experiencing their first episode of psychosis at baseline and after 12 weeks of randomized antipsychotic treatment with either aripiprazole or risperidone. At baseline, FES patients evidenced marked impairments in cognitive functioning. Notably, performance on the mazes task of planning and reasoning significantly predicted the likelihood of meeting stringent criteria for positive symptom remission during the first 12 weeks of the trial. Performance on indices of general cognitive function, working memory, and verbal learning improved over time, but these improvements were mediated by improvements in both positive and negative symptoms. We did not detect any differential effects of antipsychotic medication assignment (aripiprazole vs risperidone) on cognitive functioning. Our results suggest that a brief paper-and-pencil measure reflecting planning/reasoning abilities may index responsivity to antipsychotic medication. However, improvements in cognitive functioning over time were related to clinical symptom improvement, reflecting "pseudospecificity."

  20. Episiotomy and its relationship to various clinical variables that influence its performance

    Science.gov (United States)

    Ballesteros-Meseguer, Carmen; Carrillo-García, César; Meseguer-de-Pedro, Mariano; Canteras-Jordana, Manuel; Martínez-Roche, Mª Emilia

    2016-01-01

    Objective: to understand the episiotomy rate and its relationship with various clinical variables. Method: a descriptive, cross-sectional, analytic study of 12,093 births in a tertiary hospital. Variables: Parity, gestational age, start of labor, use of epidural analgesia, oxytocin usage, position during fetal explusion, weight of neonate, and completion of birth. The analysis was performed with SPSS 19.0. Results: the global percentage of episiotomies was 50%. The clinical variables that presented a significant association were primiparity (RR=2.98), gestational age >41 weeks (RR=1.2), augmented or induced labor (RR=1.33), epidural analgesia use (RR=1,95), oxytocin use (RR=1.58), lithotomy position during fetal expulsion (RR=6.4), and instrumentation (RR=1.84). Furthermore, maternal age ≥35 years (RR=0.85) and neonatal weight <2500 g (RR=0.8) were associated with a lower incidence of episiotomy. Conclusions: episiotomy is dependent on obstetric interventions performed during labor. If we wish to reduce the episiotomy rate, it will be necessary to bear in mind these risk factors when establishing policies for reducing this procedure. PMID:27224064

  1. [Clinical study of the relationship between the lateral recesses and the nerve roots].

    Science.gov (United States)

    Lian, P; Sun, R; Jia, L

    1997-04-01

    To explicate the relationship and the clinical signification between the normal or narrow lateral recesses and the nerve roots, we measured the diameter of the entrans zone of the lateral recess, the interval between the upper articular processes and the interval between the nerve root and ab line on 50 normal cases, 43 narrow cases and 32 stenosis cases with VIDS image analysis system. The results showed that the nerve root was in the center side of the ab line in the normal station, with the degrees of the degeneration and cohesion ncreasing, the nerve root was in the lateral recess side of the ab line, and was compressed by the lateral recess. The authors considered that the real clinical signification of the entrance zone of the lateral recess was danger to the nerve root, but the deciding factors were the degrees of the degeneration and cohesion of the upper articular processes. The pathological conditions that resulted in the stenosis of the lateral recess and dangered the nerve root such as disc, flavum ligament and posterior port of the fibra ring were discussed in the article. PMID:10374545

  2. Episiotomy and its relationship to various clinical variables that influence its performance

    Directory of Open Access Journals (Sweden)

    Carmen Ballesteros-Meseguer

    2016-01-01

    Full Text Available Objective: to understand the episiotomy rate and its relationship with various clinical variables. Method: a descriptive, cross-sectional, analytic study of 12,093 births in a tertiary hospital. Variables: Parity, gestational age, start of labor, use of epidural analgesia, oxytocin usage, position during fetal explusion, weight of neonate, and completion of birth. The analysis was performed with SPSS 19.0. Results: the global percentage of episiotomies was 50%. The clinical variables that presented a significant association were primiparity (RR=2.98, gestational age >41 weeks (RR=1.2, augmented or induced labor (RR=1.33, epidural analgesia use (RR=1,95, oxytocin use (RR=1.58, lithotomy position during fetal expulsion (RR=6.4, and instrumentation (RR=1.84. Furthermore, maternal age ≥35 years (RR=0.85 and neonatal weight <2500 g (RR=0.8 were associated with a lower incidence of episiotomy. Conclusions: episiotomy is dependent on obstetric interventions performed during labor. If we wish to reduce the episiotomy rate, it will be necessary to bear in mind these risk factors when establishing policies for reducing this procedure.

  3. A Short Version of the Revised ‘Experience of Close Relationships Questionnaire’: Investigating Non-Clinical and Clinical Samples

    OpenAIRE

    Wongpakaran, Tinakon; Wongpakaran, Nahathai

    2012-01-01

    Aim: This study seeks to investigate the psychometric properties of the short version of the revised ‘Experience of Close Relationships’ questionnaire, comparing non-clinical and clinical samples. Methods: In total 702 subjects participated in this study, of whom 531 were non-clinical participants and 171 were psychiatric patients. They completed the short version of the revised ‘Experience of Close Relationships’ questionnaire (ECR-R-18), the Perceived Stress Scale-10(PSS-10), the Rosenberg ...

  4. Study on the Relationship between Blood Stasis Syndrome and Clinical Pathology in 227 Patients with Primary Glomerular Disease

    Institute of Scientific and Technical Information of China (English)

    李深; 饶向荣; 王素霞; 张改华; 李晓玫; 戴希文; 陈可冀

    2009-01-01

    To investigate the relationship between the severity of Chinese medicine(CM) bloodstasis syndrome(BSS) with clinical features and renal lesion indexes of the primary glomerular disease. Methods:An epidemiological survey was conducted to collect the data of 227 patients diagnosed as chronic primary glomerular diseases,and their severity of BSS were scored three days before renal biopsies were performed.The following clinical indexes were analyzed:age,course of glomerular diseases,24-h urine protein ration...

  5. Relationship of Clinical Nursing Competence to Nursing Occupational Experience in Hospice/Palliative Care Nurses in Japan

    OpenAIRE

    Kaori Tsutsumi; Keiko Sekido

    2015-01-01

    Aim: The purpose of this research is to examine the relationship between the clinical nursing competence and nursing occupational experience in hospice/palliative care nurses (HPN) in Japan. Methods: A mail survey using an anonymous self-administered questionnaire was conducted on clinical nursing competence regarding communication, care and prediction of worsening of symptoms with the authors’ previous research as a framework. The subjects were nurses working in hospice/palliative care units...

  6. The relationship between MR images and clinical findings in neuronal migration disorders

    International Nuclear Information System (INIS)

    Among the variable manifestating conditions of neuronal migration disorders, mental retardation, motor disturbance and epilepsy are the main features of developmental disabilities. We analyzed the relationship between clinical symptoms and magnetic resonance (MR) images, including surface anatomy scan (SAS). Thirty-nine patients (23 males, 16 females; mean age 6.1 years) with neuronal migration disorders were studied. The diagnoses were cerebral palsy in 23 cases, mental retardation in 4, West syndrome in 4, Fukuyama type congenital muscular dystrophy (FCMD) in 6, Walker-Warburg syndrome in 1 and Dubowitz syndrome in 1. Cortical dysplasias were classified into the following 7 groups, mainly based on the SAS findings: complete agyria (AG 1), mixture of agyria and pachygyria (AG 2), bilateral complete pachygyria (BP 1), diffuse pachygyria with marked widening of the bilateral superior frontal gyrus (BP 2), unilateral pachygyria with hemispheric atrophy or hemimegalencephaly (UP), focal cortical dysplasia (FP) and other findings such as solitary schizencephaly (Others). Most cases of AG 1 and AG 2 showed spastic quadriplegia (6/7) and symptomatic generalized epilepsy (5/7), whereas cases of BP 1 showed spasticity only in 1/8 and epilepsy in 7/8. Hemiplegia was observed in 6/7 of UP, 2/8 of FP and 2/4 of Others. Partial epilepsy was observed in 2/7 of UP and 1/8 of FP. Intellectual level was variable in BP 1, UP, FP and Others, but all cases showed severe mental retardation in AG 1, AG 2 and BP 2. BP 2 was observed in all cases of typical FCMD (5/5). The birth weight was less than 2,500 g in 6/7 of UP. The structural findings well correlated with clinical symptoms and epileptic seizure types. The surface anatomy scan was a very useful technique for detecting cortical dysplasias. (author)

  7. Ferrokinetic study of splenic erythropoiesis: Relationships among clinical diagnosis, myelofibrosis, splenomegaly, and extramedullary erythropoiesis

    Energy Technology Data Exchange (ETDEWEB)

    Beguin, Y.; Fillet, G.; Bury, J.; Fairon, Y. (Univ. of Liege (Belgium))

    1989-10-01

    Splenic erythropoiesis was demonstrated by surface counting of {sup 59}Fe in 129 of 1,350 ferrokinetic studies performed over a 15 year period. These 129 studies were carried out in 108 patients, including 40 with chronic myelogenous leukemia (CML), 24 with agnogenic myeloid metaplasia (AMM), 18 with polycythemia vera (PV), six with a myelodysplastic syndrome, five with acute leukemia, three with prostate or breast carcinoma, two each with aplastic anemia or Hodgkin's disease, and one each with idiopathic thrombocythemia, multiple myeloma, chronic renal failure, or treated hypopituitarism. Splenomegaly was present in 83% of the studies and hepatomegaly in 72%. Grade II-III myelofibrosis was demonstrated in 62% of the cases. Hepatic erythropoiesis was present in 77% of the studies (only 38% in PV), and marrow erythropoiesis was undetectable in 33%. Total erythropoiesis was about twice normal (range 0.2 to 8 times normal) but was ineffective to varying degrees in 86% of the studies. Relationships between organomegaly, myelofibrosis, and extramedullary erythropoiesis, as well as differences among clinical disorders, are discussed. Differences observed between CML in chronic or blastic phase suggested that the erythroid cell line was involved in the proliferative process. It is concluded that splenic erythropoiesis (1) is encountered in a variety of clinical conditions; (2) is not necessarily associated with splenomegaly or myelofibrosis, even in the myeloproliferative disorders; (3) is part of a predominantly extramedullary (in the liver as well as in the spleen), expanded, and largely inefficient total erythropoiesis; and (4) can be evaluated in a semiquantitative manner by surface counting.

  8. The relationship between MR images and clinical findings in neuronal migration disorders

    Energy Technology Data Exchange (ETDEWEB)

    Onuma, Akira; Kobayashi, Yasuko [Takuto Rehabilitation Center for Disabled Children, Sendai (Japan); Iinuma, Kazuie

    1997-07-01

    Among the variable manifestating conditions of neuronal migration disorders, mental retardation, motor disturbance and epilepsy are the main features of developmental disabilities. We analyzed the relationship between clinical symptoms and magnetic resonance (MR) images, including surface anatomy scan (SAS). Thirty-nine patients (23 males, 16 females; mean age 6.1 years) with neuronal migration disorders were studied. The diagnoses were cerebral palsy in 23 cases, mental retardation in 4, West syndrome in 4, Fukuyama type congenital muscular dystrophy (FCMD) in 6, Walker-Warburg syndrome in 1 and Dubowitz syndrome in 1. Cortical dysplasias were classified into the following 7 groups, mainly based on the SAS findings: complete agyria (AG 1), mixture of agyria and pachygyria (AG 2), bilateral complete pachygyria (BP 1), diffuse pachygyria with marked widening of the bilateral superior frontal gyrus (BP 2), unilateral pachygyria with hemispheric atrophy or hemimegalencephaly (UP), focal cortical dysplasia (FP) and other findings such as solitary schizencephaly (Others). Most cases of AG 1 and AG 2 showed spastic quadriplegia (6/7) and symptomatic generalized epilepsy (5/7), whereas cases of BP 1 showed spasticity only in 1/8 and epilepsy in 7/8. Hemiplegia was observed in 6/7 of UP, 2/8 of FP and 2/4 of Others. Partial epilepsy was observed in 2/7 of UP and 1/8 of FP. Intellectual level was variable in BP 1, UP, FP and Others, but all cases showed severe mental retardation in AG 1, AG 2 and BP 2. BP 2 was observed in all cases of typical FCMD (5/5). The birth weight was less than 2,500 g in 6/7 of UP. The structural findings well correlated with clinical symptoms and epileptic seizure types. The surface anatomy scan was a very useful technique for detecting cortical dysplasias. (author)

  9. The relationship between radiological features and clinical manifestation and dental expenses of keratocystic odontogenic tumor

    International Nuclear Information System (INIS)

    This study was performed to identify correlations between keratocystic odontogenic tumor (KCOT) data from CT sections, and data on the KCOT clinical manifestation and resulting dental expenses. Following local Institutional Review Board (IRB) approval, a seven-years of retrospective study was performed regarding patients with KCOTs treated at the Seoul National University Dental Hospital. A total of 180 KCOT were included in this study. The following information was collected: age, gender, location and size of the lesion, radiological features, surgical treatment provided and dental expenses. There was no significant association between the size of the KCOT and age, gender, and presenting preoperative symptoms. In both jaws, it was unusual to find KCOTs under 10 mm. The correlation between the number of teeth removed and the size of the KCOT in the tooth bearing area was statistically significant in the mandible, whereas in the maxilla, no significant relationship was found. Dental expenses compared with the size of the KCOT were found to be significant in both jaws. The size of KCOT was associated with a significant increase in dental expenses for both jaws and the number of teeth removed from the mandible. These findings emphasize the importance of routine examinations and early detection of lesions, which in turn helps preserving anatomical structures and reducing dental expenses.

  10. Structure-activity relationship studies on clinically relevant HIV-1 NNRTIs.

    Science.gov (United States)

    Rawal, R K; Murugesan, V; Katti, S B

    2012-01-01

    In addition to the nucleoside reverse transcriptase inhibitors (NRTIs), protease inhibitors (PIs) and integrase inhibitors (INIs), nonnucleoside reverse transcriptase inhibitors (NNRTIs) have contributed significantly in the treatment of HIV-1 infections. More than 60 structurally different classes of compounds have been identified as NNRTIs, which are specifically inhibiting HIV-1 reverse transcriptase (RT). Five NNRTIs (nevirapine, delavirdine, efavirenz, etravirine and rilpivirine) have been approved by US Food and Drug Administration (FDA) for clinical use. The NNRTIs bind with a specific 'pocket' site of HIV-1 RT (allosteric site) that is closely associated with the NRTI binding site. Due to mutations of the amino acid residues surrounding the NNRTI-binding site, NNRTIs are notorious for rapidly eliciting resistance. Though, the emergence of resistant HIV strains can be circumvented if the NNRTIs are used either alone or in combination with NRTIs (AZT, 3TC, ddI, ddC, TVD or d4T) and PIs (Indinavir, nelfinavir, saquinavir, ritonavir and lopinavir etc.) as shown by both a decrease in plasma HIV-1 RNA levels and increased CD4 T-cells. Here we are going to discuss recent advances in structure activity relationship studies on nevirapine, delavirdine, efavirenz, etravirine, rilpivirine and 4-thiazolidinones (privileged scaffold) HIV-1 NNRTIs. PMID:22998569

  11. Clinical analysis of the risk factors for recurrence of HCC and its relationship with HBV

    Institute of Scientific and Technical Information of China (English)

    Di-Peng Ou; Lian-Yue Yang; Geng-Wen Huang; Yi-Ming Tao; Xiang Ding; Zhi-Gang Chang

    2005-01-01

    AIM: To comprehend the risk factors of recurrence of hepatocellular carcinoma (HCC) and its relationship with the infection patterns of hepatitis B virus (HBV). METHODS: All materials of 270 cases of postoperative HCC were statistically analyzed by SPSS software. Recurrence and metastasis were classified into early (≤2 years) and late phase (>2 years). Risk factors for recurrence and metastasis after surgery in each group were analyzed.RESULTS: Out of 270 cases of HCC, 162 cases were followed up in which recurrence and metastasis occurred in 136 cases. There were a lot of risk factors related to recurrence and metastasis of HCC; risk factors contributing to early phase recurrence were serum AFP level, vascular invasion, incisal margin and operative transfusion, gross tumor classification and number of intrahepatic node to late phase recurrence. The HBV infective rate of recurrent HCC was 94.1%, in which "HBsAg, HBeAb, HBcAb" positive pattern reached 45.6%. The proportion of HBV infection in solitary large hepatocellular carcinoma (SLHCC) evidently decreased compared to nodular hepatocellular carcinoma (NHCC) (P<0.05).CONCLUSION: The early and late recurrence and metastasis after hepatectomy of HCC were associated with different risk factors. The early recurrence may be mediated by vascular invasion and remnant lesion, the late recurrence by tumor's clinical pathology propert, as multicentric carcinogenesis or intrahepatic carcinoma denovo. HBV replication takes a great role in this process. From this study, we found that SLHCC has more satisfactory neoplasm biological behavior than NHCC.

  12. Self esteem and self agency in first episode psychosis: Ethnic variation and relationship with clinical presentation.

    Science.gov (United States)

    Ciufolini, Simone; Morgan, Craig; Morgan, Kevin; Fearon, Paul; Boydell, Jane; Hutchinson, Gerard; Demjaha, Arsjme; Girardi, Paolo; Doody, Gill A; Jones, Peter B; Murray, Robin; Dazzan, Paola

    2015-06-30

    The impact of self esteem and Locus of Control (LoC) on clinical presentation across different ethnic groups of patients at their first psychotic episode (FEP) remains unknown. We explored these constructs in 257 FEP patients (Black n=95; White British n=119) and 341 controls (Black n=70; White British n=226), and examined their relationship with symptom dimensions and pathways to care. FEP patients presented lower self-esteem and a more external LoC than controls. Lower self esteem was associated with a specific symptoms profile (more manic and less negative symptoms), and with factors predictive of poorer outcome (longer duration of untreated psychosis (DUP) and compulsory mode of admission). A more external LoC was associated with more negative symptoms and an insidious onset. When we explored these constructs across different ethnic groups, we found that Black patients had significantly higher self esteem than White British. This was again associated with specific symptom profiles. While British patients with lower self esteem were more likely to report delusions, hallucinations and negative symptoms, Black patients with a lower self esteem showed less disorganization symptoms. These findings suggest that self esteem and LoC may represent one way in which social experiences and contexts differentially influence vulnerable individuals along the pathway to psychosis.

  13. Exploring the dimensions of doctor-patient relationship in clinical practice in hospital settings.

    Science.gov (United States)

    Shrivastava, Saurabh RamBiharilal; Shrivastava, Prateek Saurabh; Ramasamy, Jegadeesh

    2014-05-01

    The Doctor-Patient Relationship (DPR) is a complex concept in the medical sociology in which patients voluntarily approach a doctor and thus become a part of a contract in which they tends to abide with the doctor's guidance. Globally, the DPR has changed drastically over the years owing to the commercialization and privatization of the health sector. Furthermore, the dynamics of the DPR has shown a significant change because of the formulation of consumer protection acts; clauses for professional misconduct and criminal negligence; establishment of patient forums and organizations; massive expansion of the mass media sector leading to increase in health awareness among people; and changes in the status of the doctors. Realizing the importance of DPR in the final outcome and quality of life of the patient, multiple measures have been suggested to make a correct diagnosis and enhance healing. To conclude, good DPR is the crucial determinant for a better clinical outcome and satisfaction with the patients, irrespective of the socio-cultural determinants.

  14. Exploring the Dimensions of Doctor-Patient Relationship in Clinical Practice in Hospital Settings

    Directory of Open Access Journals (Sweden)

    Saurabh RamBiharilal Shrivastava

    2014-05-01

    Full Text Available The Doctor-Patient Relationship (DPR is a complex concept in the medical sociology in which patients voluntarily approach a doctor and thus become a part of a contract in which they tends to abide with the doctor’s guidance. Globally, the DPR has changed drastically over the years owing to the commercialization and privatization of the health sector. Furthermore, the dynamics of the DPR has shown a significant change because of the formulation of consumer protection acts; clauses for professional misconduct and criminal negligence; establishment of patient forums and organizations; massive expansion of the mass media sector leading to increase in health awareness among people; and changes in the status of the doctors. Realizing the importance of DPR in the final outcome and quality of life of the patient, multiple measures have been suggested to make a correct diagnosis and enhance healing. To conclude, good DPR is the crucial determinant for a better clinical outcome and satisfaction with the patients, irrespective of the socio-cultural determinants.

  15. The relationship between radiological features and clinical manifestation and dental expenses of keratocystic odontogenic tumor

    Energy Technology Data Exchange (ETDEWEB)

    Min, Jung Hyun; Huh, Kyung Heo; Heo, Min Suk; Choi, Soon Chul; Lee, Sam Sun; Bae, Kwang Hak [Dept. of School of Dentistry, Seoul National University, Seoul (Korea, Republic of); Choi, Jin Woo [Dept. of Oral and Maxillofacial Radiology, Dankook University College of Dentistry, Cheonan (Korea, Republic of)

    2013-06-15

    This study was performed to identify correlations between keratocystic odontogenic tumor (KCOT) data from CT sections, and data on the KCOT clinical manifestation and resulting dental expenses. Following local Institutional Review Board (IRB) approval, a seven-years of retrospective study was performed regarding patients with KCOTs treated at the Seoul National University Dental Hospital. A total of 180 KCOT were included in this study. The following information was collected: age, gender, location and size of the lesion, radiological features, surgical treatment provided and dental expenses. There was no significant association between the size of the KCOT and age, gender, and presenting preoperative symptoms. In both jaws, it was unusual to find KCOTs under 10 mm. The correlation between the number of teeth removed and the size of the KCOT in the tooth bearing area was statistically significant in the mandible, whereas in the maxilla, no significant relationship was found. Dental expenses compared with the size of the KCOT were found to be significant in both jaws. The size of KCOT was associated with a significant increase in dental expenses for both jaws and the number of teeth removed from the mandible. These findings emphasize the importance of routine examinations and early detection of lesions, which in turn helps preserving anatomical structures and reducing dental expenses.

  16. Structure-activity relationship studies on clinically relevant HIV-1 NNRTIs.

    Science.gov (United States)

    Rawal, R K; Murugesan, V; Katti, S B

    2012-01-01

    In addition to the nucleoside reverse transcriptase inhibitors (NRTIs), protease inhibitors (PIs) and integrase inhibitors (INIs), nonnucleoside reverse transcriptase inhibitors (NNRTIs) have contributed significantly in the treatment of HIV-1 infections. More than 60 structurally different classes of compounds have been identified as NNRTIs, which are specifically inhibiting HIV-1 reverse transcriptase (RT). Five NNRTIs (nevirapine, delavirdine, efavirenz, etravirine and rilpivirine) have been approved by US Food and Drug Administration (FDA) for clinical use. The NNRTIs bind with a specific 'pocket' site of HIV-1 RT (allosteric site) that is closely associated with the NRTI binding site. Due to mutations of the amino acid residues surrounding the NNRTI-binding site, NNRTIs are notorious for rapidly eliciting resistance. Though, the emergence of resistant HIV strains can be circumvented if the NNRTIs are used either alone or in combination with NRTIs (AZT, 3TC, ddI, ddC, TVD or d4T) and PIs (Indinavir, nelfinavir, saquinavir, ritonavir and lopinavir etc.) as shown by both a decrease in plasma HIV-1 RNA levels and increased CD4 T-cells. Here we are going to discuss recent advances in structure activity relationship studies on nevirapine, delavirdine, efavirenz, etravirine, rilpivirine and 4-thiazolidinones (privileged scaffold) HIV-1 NNRTIs.

  17. Factor V leiden mutation in Behcet’s disease and the relationship with clinical manifestations

    Directory of Open Access Journals (Sweden)

    Mowla K

    2010-05-01

    Full Text Available "n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Behcet's disease (BD is a multisystemic inflammatory disease with unknown origin characterized by recurrent oral aphtous ulcers, genital, ocular and skin lesions. A single point mutation 1691G to A in the factor V gene increases the risk of venous thrombosis. This study designed to determine factor V Leiden mutation in Behcet's disease, and to find out it's relationship with the clinical manifestations in Khuzestan province, Iran. "n"nMethods: One hundred patients with Behcet's Disease (44 males and 56 females based on international diagnostic criteria and 70 healthy subjects were included in the study. Patients and controls were tested for the presence of factor V Leiden mutation using polymerase chain reaction method."n"nResults: The prevalence of factor V Leiden mutation was significantly higher in BD (10 out of 100, 10% compared with healthy control subjects (1 out of 70, 1.4%, (p=0.025. Vascular lesions in this study were deep vein thrombosis (DVT (7%, subcutaneous thrombophlebitis (5%, stroke (1% and retinal vasculitis (39%. It was found that there was no association between venous thrombosis and the factor V Leiden mutation in Khuzestanian patients. Also, no association between

  18. The relationship between the angiographic findings and the clinical features of carotid artery plaque.

    Science.gov (United States)

    Kim, D I; Lee, S J; Lee, B B; Kim, Y I; Chung, C S; Seo, D W; Lee, K H; Ko, Y H; Kim, D K; Do, Y S; Byun, H S

    2000-01-01

    The purpose of this study was to investigate the histological characteristics of atheromatous carotid plaque, and to analyze the relationship between the angiographic findings and the clinical features. We retrospectively reviewed 55 cases of carotid endarterectomy for extracranial internal carotid artery stenosis, who were treated at our institute from January 1995 to December 1997. The histological examination included hematoxylin-eosin staining, Masson-trichrome staining, and immunostaining for antismooth muscle antibody and anti-CD68 antibody. The main compositions of the carotid plaque included synthetic type vascular smooth muscle cells and extracellular matrix. The histological findings showed ulceration in 49 (89.1%) cases, calcium deposits in 42 (76.4%) cases, and an inflammatory reaction in 44 (80.0%) cases. Neurological abnormalities were strongly associated with plaque ulceration (P = 0.045) and an inflammatory reaction (P = 0.013), whereas no correlation existed regarding calcium deposits (P = 0.173). The angiographic findings showed ulceration in 46 (83.6%) cases. Plaque ulceration in the angiography findings showed no statistically significant correlation with the histologic findings (P = 0.410) and preoperative neurologic abnormalities (P = 0.059). All of the atherosclerotic risk factors such as hypertension, smoking, diabetes mellitus, hyperlipidemia, and myocardial infarction had no statistically significant correlation with the histological features of the carotid plaque. In conclusion, the main compositions of carotid plaque were synthetic-type vascular smooth muscle cells and extracellular matrix. The histological ulceration and inflammatory reaction of the plaque showed a statistically significant correlation with the preoperative neurologic symptoms, whereas no correlation was seen in the calcium deposits. Angiographic ulceration showed no correlation with the histological findings or preoperative neurologic abnormalities. In addition, the

  19. Comparative Genomic Analysis of Clinical and Environmental Vibrio Vulnificus Isolates Revealed Biotype 3 Evolutionary Relationships

    Directory of Open Access Journals (Sweden)

    Yael eKotton

    2015-01-01

    Full Text Available In 1996 a common-source outbreak of severe soft tissue and bloodstream infections erupted among Israeli fish farmers and fish consumers due to changes in fish marketing policies. The causative pathogen was a new strain of Vibrio vulnificus, named biotype 3, which displayed a unique biochemical and genotypic profile. Initial observations suggested that the pathogen erupted as a result of genetic recombination between two distinct populations. We applied a whole genome shotgun sequencing approach using several V. vulnificus strains from Israel in order to study the pan genome of V. vulnificus and determine the phylogenetic relationship of biotype 3 with existing populations. The core genome of V. vulnificus based on 16 draft and complete genomes consisted of 3068 genes, representing between 59% and 78% of the whole genome of 16 strains. The accessory genome varied in size from 781 kbp to 2044 kbp. Phylogenetic analysis based on whole, core, and accessory genomes displayed similar clustering patterns with two main clusters, clinical (C and environmental (E, all biotype 3 strains formed a distinct group within the E cluster. Annotation of accessory genomic regions found in biotype 3 strains and absent from the core genome yielded 1732 genes, of which the vast majority encoded hypothetical proteins, phage-related proteins, and mobile element proteins. A total of 1916 proteins (including 713 hypothetical proteins were present in all human pathogenic strains (both biotype 3 and non-biotype 3 and absent from the environmental strains. Clustering analysis of the non-hypothetical proteins revealed 148 protein clusters shared by all human pathogenic strains; these included transcriptional regulators, arylsulfatases, methyl-accepting chemotaxis proteins, acetyltransferases, GGDEF family proteins, transposases, type IV secretory system (T4SS proteins, and integrases. Our study showed that V. vulnificus biotype 3 evolved from environmental populations and

  20. Illness, body and relationship: Giovanni Jervis and the field of clinical psychology.

    Science.gov (United States)

    Williams, Riccardo

    2012-01-01

    Unlike most of his contemporaries, Jervis felt it was necessary to give new answers to last century's clinical psychology crisis. He managed to show the relevance that psychological knowledge coming from other sectors (such as philosophy, evolutionary biology, cybernetics, ethology and, nowadays, neuroscience) could have for clinical psychology. He realized that the clinical world was at risk of loosing its cultural models of reference and threatened to break up with the scientific tradition with which it had not been able to establish a profitable dialogue. Jervis' views on mental functioning allowed him to delimit the field of action of clinical psychology. The focus on pathology and existential distress suggested that correct clinical evaluation and diagnosis are at the core of the activity of clinical psychologists. The tension between relational expectations, self-deceptive aspects of identity and the bodily sources of mental life show the dynamic field on which clinical psychology can deploy its transformative action.

  1. [Relationship between the courses of clinical Features of patients with schizophrenia in adolescents and admission to psychiatric clinic].

    Science.gov (United States)

    Hattori, Isao; Miyauchi, Toshiro

    2005-01-01

    In order to improve diagnosis of schizophrenia with onset in adolescents at an early stage, we investigated in detail the clinical features of 74 patients with schizophrenia, (23 males) at adolescents psychiatric clinic. Many of the subjects had been suffering from the illness about 14 years old but had not undergone their first psychiatric examination until a few years later. A high percentage (more than 80%) of our subjects presented psychiatric symptoms such as delusional remembrance, delusional moods, delusions of persecution and hypobulia. Additionally, more than 60% of our subjects presented auditory hallucinations. In general, teenage patients with schizophrenia onset show vague symptoms such as anxiety, embarrassment and strange moods rather than obvious hallucinations. Nevertheless, it was possible to identify certain clinical features of this disorder in adolescents: many patients suffer delusional remembrance, delusional moods and delusions of persecution immediately after the onset of the illness. Gradually, problematic behaviors such as anorexia, self injury, offences against their families, voluntary vomiting, etc., develop, but patients do not always receive psychiatric examination at this stage. After socially obvious problems such as school refusal, withdrawal from social activities and lowering of school record develop over a period of time, patients may be urged to undergo psychiatric examination. Our research again underlines the difficulty of achieving diagnosis of schizophrenia at an early stage. The key to early diagnosis appears to be the accurate identification of psychiatric symptoms in the early stages of the illness at school, or at home if possible, before socially problematic behaviors arise.

  2. The relationship between learning preferences (styles and approaches) and learning outcomes among pre-clinical undergraduate medical students

    OpenAIRE

    Liew, Siaw-Cheok; Sidhu, Jagmohni; Barua, Ankur

    2015-01-01

    Background Learning styles and approaches of individual undergraduate medical students vary considerably and as a consequence, their learning needs also differ from one student to another. This study was conducted to identify different learning styles and approaches of pre-clinical, undergraduate medical students and also to determine the relationships of learning preferences with performances in the summative examinations. Methods A cross-sectional study was conducted among randomly selected...

  3. Detection of human herpes viruses in patients with chronic and aggressive periodontitis and relationship between viruses and clinical parameters

    OpenAIRE

    Das, Sushma; Krithiga, G Shobha Prakash; Gopalakrishnan, S.

    2012-01-01

    Background and Aims: Recent microbiological researches have revealed the possible role of human cytomegalovirus (HCMV), Epstein barr virus (EBV), and herpes simplex virus (HSV-1 and HSV-2) in the etiopathogenesis of periodontal diseases. The present pilot study has been undertaken to detect the presence of these viruses in chronic periodontitis, aggressive periodontitis, and healthy individuals and to determine the relationship between these viruses and the clinical parameters. Materials and ...

  4. CPTAC Establishes Formal Relationships with Two Academic Institutions in Taiwan - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium (CPTAC) has entered into memorandum of understandings (MOUs) with Chang Gung University and Academia Sinica, in Taipei, Taiwan.

  5. Relationship of neuroimaging to typical sleep times during a clinical reasoning task: a pilot study

    NARCIS (Netherlands)

    Durning, S.J.; Kelly, W.; Costanzo, M.E.; Artino, A.R.; Vleuten, C.P.M. van der; Beckman, T.J.; Roy, M.J.H.M. van; Holmboe, E.S.; Wittich, C.M.; Schuwirth, L.

    2015-01-01

    BACKGROUND: Sleep deprivation and fatigue have been associated with medical errors, clinical performance decrements, and reduced quality of life for both practicing physicians and medical students. Greater understanding of the impact of sleep quantity on clinical reasoning could improve patient care

  6. Delineation of Streptococcus dysgalactiae, its subspecies, and its clinical and phylogenetic relationship to Streptococcus pyogenes

    DEFF Research Database (Denmark)

    Jensen, Anders; Kilian, Mogens

    2011-01-01

    The close phylogenetic relationship of the important pathogen Streptococcus pneumoniae and several species of commensal streptococci, particularly Streptococcus mitis and Streptococcus pseudopneumoniae, and the recently demonstrated sharing of genes and phenotypic traits previously considered...

  7. The relationship between visual orienting responses and clinical characteristics in children attending special education for the visually impaired.

    Science.gov (United States)

    Kooiker, Marlou J G; Pel, Johan J M; van der Steen, Johannes

    2015-05-01

    We recently introduced a method based on quantification of orienting responses toward visual stimuli to assess the quality of visual information processing in children. In the present study, we examined the relationship between orienting responses and factors that are associated with visual processing impairments in current clinical practice. Response time and fixation quality to visual features such as form, contrast, motion, and color stimuli were assessed in 104 children from 1 to 12 years attending special education for the visually impaired. Using regression analysis, we investigated whether these parameters were affected by clinical characteristics of children. Response times significantly depended on stimulus type. Responses to high-contrast cartoons were significantly slower in children with a clinical diagnosis of cerebral visual impairment. Fixation quality was significantly affected by visual acuity and nystagmus. The results suggest that the quantitative measurement of orienting responses is strongly related to cerebral visual impairment in children.

  8. The relationship between South Korean clinical nurses' attitudes toward organizations and voluntary turnover intention: A path analysis.

    Science.gov (United States)

    Kim, Jong Kyung; Chang, Sun Ju

    2015-08-01

    The purpose of this study was to examine the relationship between attitudes toward their organizations and voluntary turnover intention among South Korean clinical nurses. Data from a total of 312 clinical nurses in six hospitals in South Korea were collected for the study. Both hierarchical multiple regression analysis and path analysis were used to analyse the data. The overall fit of the hypothetical model was good. Voluntary turnover intention was found to have significant direct pathways to job embeddedness and organizational commitment. Organizational commitment and satisfaction with organizational rewards had indirect pathways to voluntary turnover intention through job embeddedness. All variances explained 62.3% of the voluntary turnover intention scores. The findings suggest that greater job embeddedness, organizational commitment and satisfaction with organizational rewards lead to lower voluntary turnover intention among clinical nurses in South Korea. PMID:24666586

  9. Relationship between ABO blood groups and malaria with clinical outcome in rural area of South India

    OpenAIRE

    Gayathri B.N.; Harendra Kumar M.L.; Gomathi. N.; Jeevan Shetty; Reethesh R. P.

    2013-01-01

    Background A number of studies have shown that susceptibility to several infectious diseases is related to the patient’s blood group. Although the relationship between blood group and susceptibility to malaria has been studied by several researchers, the results have been contradictory. Since malaria has re-emerged as a major problem in India during the past few years, it would be useful to know whether there is any relationship between blood group and infection. Objectives The study will be...

  10. Genetic relationships between clinical and non-clinical strains of Yersinia enterocolitica biovar 1A as revealed by multilocus enzyme electrophoresis and multilocus restriction typing

    Directory of Open Access Journals (Sweden)

    Virdi Jugsharan S

    2010-05-01

    Full Text Available Abstract Background Genetic relationships among 81 strains of Y. enterocolitica biovar 1A isolated from clinical and non-clinical sources were discerned by multilocus enzyme electrophoresis (MLEE and multilocus restriction typing (MLRT using six loci each. Such studies may reveal associations between the genotypes of the strains and their sources of isolation. Results All loci were polymorphic and generated 62 electrophoretic types (ETs and 12 restriction types (RTs. The mean genetic diversity (H of the strains by MLEE and MLRT was 0.566 and 0.441 respectively. MLEE (DI = 0.98 was more discriminatory and clustered Y. enterocolitica biovar 1A strains into four groups, while MLRT (DI = 0.77 identified two distinct groups. BURST (Based Upon Related Sequence Types analysis of the MLRT data suggested aquatic serotype O:6,30-6,31 isolates to be the ancestral strains from which, clinical O:6,30-6,31 strains might have originated by host adaptation and genetic change. Conclusion MLEE revealed greater genetic diversity among strains of Y. enterocolitica biovar 1A and clustered strains in four groups, while MLRT grouped the strains into two groups. BURST analysis of MLRT data nevertheless provided newer insights into the probable evolution of clinical strains from aquatic strains.

  11. Distinct features of circulating microparticles and their relationship to clinical manifestations in systemic lupus erythematosus

    DEFF Research Database (Denmark)

    Nielsen, Christoffer T; Østergaard, Ole; Johnsen, Christina;

    2011-01-01

    Characterization of the abundance, origin, and annexin V (AnxV)-binding capabilities of circulating microparticles (MPs) in SLE patients and healthy controls and to determine any associations with clinical parameters....

  12. The Relationship between Clinical and Chemical Hyperandrogenism in 14-18-Years- Old Girls

    OpenAIRE

    Tahereh Naderi; Marzieh Akbarzadeh; Mohammad Hossain Dabbaghmanesh; Hamidreza Tabatabaee; Zahra Zareh

    2012-01-01

    Background: One of the most common endocrine disorders in women's medicine is the increased androgen and the symptoms of increased androgens in women such as polycystic ovary syndrome. The two main components to diagnose this syndrome are menstrual disorder and clinical or laboratory hyperandrogenism, but other causes should be ruled out in order to confirm the diagnosis. This study aims to examine clinical Hyperandrogenism in female students of 14 to 18 years old in Shiraz in 2010.Materials ...

  13. Atypical ultrasound features of parathyroid tumours may bear a relationship to their clinical and biochemical presentation

    OpenAIRE

    Chandramohan, Anuradha; Sathyakumar, Kirthi; John, Reetu Amrita; Manipadam, Marie Therese; Abraham, Deepak; Thomas V Paul; Thomas, Nihal; Paul, M. J.

    2013-01-01

    Objectives To describe atypical ultrasound features of parathyroid lesions and correlate them with clinical presentation and histopathology. Materials and methods Retrospective review of 264 patients with primary hyperparathyroidism who underwent ultrasound imaging prior to parathyroidectomy was performed. Patients with atypical ultrasound findings (n = 26) were identified; imaging findings were correlated with clinical presentation and histopathology. Results Twenty-one (80 %) lesions were a...

  14. Comorbidity of Anxiety Disorders and Substance Abusewith Bipolar Mood Disorders and Relationship with ClinicalCourse

    OpenAIRE

    Ali Reza Shafiee-Kandjani; Javad Golmirzaei; Salam Bakhshi; Shahrokh Amiri; Mohammad Ali Ghoreishizadeh

    2009-01-01

    "n Objective: Patients with bipolar mood disorder constitute a relatively large number of individuals hospitalized in psychiatric hospitals. This disorder is highly co-morbid with other psychiatric disorders and may effect their clinical course. The goal of this study was to determine the co-occurrence rate of anxiety disorders and substance abuse with bipolar mood disorders and their impact on clinical course. "n Methods: 153 bipolar patients (type I) were selected among the hospitalize...

  15. The Relationship between Explanatory Style and Posttraumatic Growth after Bereavement in a Non-Clinical Sample

    Science.gov (United States)

    Ho, Samuel M. Y.; Chu, Kwung Wing; Yiu, Jessie

    2008-01-01

    The relationship between explanatory style and self-perceived posttraumatic growth was examined among 105 undergraduates in Hong Kong who had experienced bereavement in the past 6 years. Individuals who tended to attribute positive events to internal, global, and stable factors reported more posttraumatic growth than individuals who tended to…

  16. Relationship between obesity and the risk of clinically significant depression: Mendelian randomisation study.

    LENUS (Irish Health Repository)

    Hung, Chi-Fa

    2014-07-01

    Obesity has been shown to be associated with depression and it has been suggested that higher body mass index (BMI) increases the risk of depression and other common mental disorders. However, the causal relationship remains unclear and Mendelian randomisation, a form of instrumental variable analysis, has recently been employed to attempt to resolve this issue.

  17. The Relationship of Asperger's Characteristics and Schizotypal Personality Traits in a Non-Clinical Adult Sample

    Science.gov (United States)

    Hurst, Ruth M.; Nelson-Gray, Rosemery O.; Mitchell, John T.; Kwapil, Thomas R.

    2007-01-01

    The study examines the relationship between Asperger's Disorder (AD) and Schizotypal Personality Disorder (SPD), mutually exclusive but similar diagnoses ["DSM-IV-TR;" American Psychiatric Association (2000). "Diagnostic and statistical manual of mental disorders." Washington, DC: Author]. The literature and comparison of diagnostic criteria…

  18. Biofilm formation in clinical isolates of nosocomial Acinetobacter baumannii and its relationship with multidrug resistance

    Institute of Scientific and Technical Information of China (English)

    Ebrahim Babapour; Azam Haddadi; Reza Mirnejad; Seyed-Abdolhamid Angaji; Nour Amirmozafari

    2016-01-01

    Objective: To check biofilm formation by Acinetobacter baumannii (A. baumannii) clinical isolates and show their susceptibility to different antibiotics and investigate a possible link between establishment of biofilm and multidrug resistance. Methods: This study was performed on clinical samples collected from patients with nosocomial infections in three hospitals of Tehran. Samples were initially screened by culture and biochemical tests for the presence of different species of Acinetobacter. Iden-tifications were further confirmed by PCR assays. Their susceptibilities to 11 antibiotics of different classes were determined by disc diffusion method according to Clinical and Laboratory Standards Institute guidelines. The ability to produce biofilm was investigated using methods:culture on Congo red agar, microtiter plate, and test tube method. Results: From the overall clinical samples, 156 specimens were confirmed to contain A. baumannii. The bacteria were highly resistant to most antibiotics except polymyxin B. Of these isolates, 10.26% were able to produce biofilms as shown on Congo red agar. However, the percentage of bacteria with positive biofilm in test tube, standard microtiter plate, and modified microtiter plate assays were 48.72%, 66.66%, and 73.72%, respec-tively. At least 92%of the biofilm forming isolates were multidrug resistant. Conclusions: Since most of the multidrug resistant strains produce biofilm, it seems necessary to provide continuous monitoring and determination of antibiotic susceptibility of clinical A. baumannii. This would help to select the most appropriate antibiotic for treatment.

  19. Clinical relationships tested by iatrogenicity: the case of haemophiliac patients faced with the epidemic of transfusional AIDS.

    Science.gov (United States)

    Fillion, Emmanuelle

    2008-11-01

    After being victims of a serious iatrogenous damage, what kind of relationship can patients rebuild with the world of medicine? In this article, I examine this question in terms of the contaminated blood affair in France. Using a qualitative study of haemophiliac patients and their families as a base, I looked at the changes in their modes of commitment to medicine, from the period preceding contamination with AIDS through blood transfusion, until the present day. It would seem that the experience of iatrogenous injustice was at the root of a major reconfiguration: all of the patients looked back over their trajectories, examined their relationship with the medical world and changed their positions, but without necessarily drawing the same conclusions or taking the same stances. This article looks at the change from relationships essentially based on cooperation to relationships that are more negotiated. It also shows the current diversity in forms of commitment: they are the fruit of critical work, carried out by patients and their families, which reassesses both the cognitive and moral bases of medical legitimacy. The analysis of the reconfiguration of the relationships that haemophiliac patients have had with the medical world in the aftermath of the contaminated blood affair is enlightening in two ways. First of all, the current medical world would appear to be deeply marked by health scandals and the victims have become prime actors. Secondly, the experience of iatrogenicity asks, with especial acuteness, the question of confidence that is at the core of any clinical relationship. It thus has a heuristic value of general scope. PMID:18715682

  20. The relationships among clinical depression, suicide, and other actions that may hasten death.

    Science.gov (United States)

    Werth, James L

    2004-01-01

    Clinical depression and other psychological disorders have been associated with suicidal ideation, attempts, and deaths. Because of the link between suicide and mental illness, whenever discussion of "assisted suicide" arises, the possibility that major depression is affecting the decision arises. This article examines the literature on clinical depression as it relates to suicide, "assisted suicide," and other decisions that will hasten death (i.e. withholding and withdrawing treatment, terminal sedation, and voluntarily stopping eating and drinking). Ethical and legal considerations when working with individuals who are considering taking an action that would hasten death are also briefly reviewed. The article ends with practice and policy recommendations. PMID:15378592

  1. Relationship between Histological and Clinical Course of Psoriasis: A Pilot Investigation by Reflectance Confocal Microscopy during Goeckerman Treatment.

    Science.gov (United States)

    Archid, Rami; Duerr, Hans Peter; Patzelt, Alexa; Philipp, Sandra; Röwert-Huber, Hans-Joachim; Ulrich, Martina; Meinke, Martina Claudia; Knorr, Fanny; Lademann, Jürgen

    2016-01-01

    Alterations of the skin microvasculature are known to play an important role in the development and maintenance of psoriatic skin lesions. In this study, we investigated lesional skin in 11 psoriatic patients during a modified Goeckerman treatment using reflectance confocal microscopy (RCM) to study the relationship between clinical clearance and histological normalization of psoriatic skin and the significance of histological abnormalities on the course of disease. The treatment regimen resulted in a significant reduction of the Psoriasis Area and Severity Index (PASI) as well as capillary and papillary diameters (p RCM findings as successor of the PASI in the monitoring of psoriasis. PMID:26841099

  2. Building relationships with physicians. Internal marketing efforts help strengthen organizational bonds at a rural health care clinic.

    Science.gov (United States)

    Peltier, J W; Boyt, T; Westfall, J E

    1997-01-01

    Physician turnover is costly for health care organizations, especially for rural organizations. One approach management can take to reduce turnover is to promote physician loyalty by treating them as an important customer segment. The authors develop an information--oriented framework for generating physician loyalty and illustrate how this framework has helped to eliminate physician turnover at a rural health care clinic. Rural health care organizations must develop a more internal marketing orientation in their approach to establishing strong relationship bonds with physicians. PMID:10173904

  3. Poststroke Shoulder Pain in Turkish Stroke Patients: Relationship with Clinical Factors and Functional Outcomes

    Science.gov (United States)

    Barlak, Aysegul; Unsal, Sibel; Kaya, Kurtulus; Sahin-Onat, Sule; Ozel, Sumru

    2009-01-01

    The objective of this study was to assess the possible causes of hemiplegic shoulder pain (HSP) in Turkish patients with stroke, to identify the correlation between HSP and clinical factors, and to review the effects of HSP on functional outcomes. A total of 187 consecutive patients with stroke were evaluated for the presence of HSP and for the…

  4. Relationship Between Upper Respiratory Tract Influenza Test Result and Clinical Outcomes Among Critically Ill Influenza Patients

    OpenAIRE

    Reddy, Krishna P.; Bajwa, Ednan K.; Parker, Robert A.; Andrew B Onderdonk; Walensky, Rochelle P.

    2016-01-01

    Among critically ill patients with lower respiratory tract (LRT)-confirmed influenza, we retrospectively observed worse 28-day clinical outcomes in upper respiratory tract (URT)-negative versus URT-positive subjects. This finding may reflect disease progression and highlights the need for influenza testing of both URT and LRT specimens to improve diagnostic yield and possibly inform prognosis.

  5. The Relationship between Athletic Training Student Critical Thinking Skills and Clinical Instructor Supervision: A Pilot Study

    Science.gov (United States)

    Kabay, Michele R.

    2013-01-01

    The purpose of this study was to 1) assess the critical thinking skill level of the athletic training student at onset and end of the clinical education experience 2) to examine the influence of the students' critical thinking skills and the CIs' supervision responses to the changes in the students' critical thinking skills and 3) to compare the…

  6. The Relationship between Emotional Intelligence, Self-Efficacy, and Clinical Performance in Associate Degree Nursing Students

    Science.gov (United States)

    Rice, Eileen W.

    2013-01-01

    The purpose of this study was to explore self-efficacy, an individual's beliefs about his or her ability to perform a series of tasks, and emotional intelligence, an individual's ability to perceive, use, understand, and manage emotions, as predictors for successful clinical performance in nursing students. The participants were 49 female and 7…

  7. The Relationship of Anxiety to Personality and Clinical Characteristics of a Prison Population.

    Science.gov (United States)

    Richmond, Bert O.; And Others

    1985-01-01

    Administered the Clinical Analysis Questionnaire and the What I Think and Feel test to 159 male prisoners. Participants reported low levels of anxiety and an absence of debilitating personality characteristics, suggesting the absence of a criminal personality that is a separate and distinct type of personality. (JAC)

  8. Carbon-13 magnetic resonance chemical shift additivity relationships of clinically used furocoumarins and furchromones

    International Nuclear Information System (INIS)

    The natural abundance carbon-13 nuclear magnetic resonance spectra of various clinically used furocoumarins and furochromones have been studied. The assignments of carbon chemical shift values were based on the theory of chemical shift, additivity rules, SFORD spectra and model compounds. (author)

  9. The relationship of childhood bullying and paranoid thinking in a clinical population: the role of mediators

    OpenAIRE

    Chaudhry, Khadija

    2012-01-01

    A wealth of research evidence has been accumulating over the last two decades, highlighting the association of childhood trauma and psychosis. The literature review evaluates empirical evidence and builds upon the previous literature reviews in this area. In addition, the literature review examines the theoretical bases and the underlying psychological factors that contribute to the relationship between childhood trauma and psychosis. It concluded that despite a large body of literature on th...

  10. Relationship between initial clinical presentation and the molecular cytogenetic classification of myeloma

    OpenAIRE

    Greenberg, Alexandra J; Rajkumar, S. Vincent; Therneau, Terry M.; Singh, Preet P; Dispenzieri, Angela; Kumar, Shaji K.

    2013-01-01

    Multiple Myeloma (MM) consists of several distinct cytogenetic subtypes, and we hypothesized that each subtype may have a unique mode of initial presentation and end-organ damage. We studied 484 patients with newly diagnosed MM were to determine the relationship between specific myeloma-defining event (MDE) and the cytogenetic subtype. Patients were divided into 4 non-overlapping groups based on the MDE at diagnosis: isolated renal failure, isolated anemia, isolated lytic bone disease, or a c...

  11. Telomere length in non-neoplastic colonic mucosa in ulcerative colitis (UC) and its relationship to the severe clinical phenotypes.

    Science.gov (United States)

    Tahara, Tomomitsu; Shibata, Tomoyuki; Okubo, Masaaki; Kawamura, Tomohiko; Sumi, Kazuya; Ishizuka, Takamitsu; Nakamura, Masakatsu; Nagasaka, Mitsuo; Nakagawa, Yoshihito; Ohmiya, Naoki; Arisawa, Tomiyasu; Hirata, Ichiro

    2015-08-01

    Telomere shortening occurs with human aging in many organs and tissues and is accelerated by rapid cell turnover and oxidative injury. To clarify the clinical importance of telomere shortening in colonic mucosa in ulcerative colitis (UC), we measured average telomere length using quantitative real-time PCR in non-neoplastic colonic mucosa in UC patients and assessed its relationship to various clinical subtypes. Relative telomere length in genomic DNA was measured in colonic biopsies obtained from rectal inflammatory mucosa from 86 UC patients as well as paired non-inflammatory proximal colonic mucosae from 10 patients. Data were correlated with various clinical phenotypes. In paired samples, average relative telomere length of rectal inflammatory mucosa was shortened compared to normal appearing proximal colon in eight out of ten cases (p = 0.01). Telomere length shortening was significantly associated with more severe Mayo endoscopic subscore (p telomere length was significantly shortened in the same phenotypes than the others (p = 0.003). Telomere shortening is associated with more severe clinical phenotypes of UC, reflecting severe inflammatory state in the colonic mucosa.

  12. Clinical anxiety, cortisol and interleukin-6: evidence for specificity in emotion-biology relationships.

    LENUS (Irish Health Repository)

    O'Donovan, Aoife

    2012-02-01

    Anxiety confers increased risk for inflammatory diseases, and elevated inflammatory activity in anxious individuals may contribute to this increased risk. One complication, however, is that anxiety could be associated with inflammatory activity either through a specific anxiety pathway or through a more general negative emotionality pathway. To investigate, we measured levels of the stress hormone cortisol, the pro-inflammatory cytokine interleukin-6 (IL-6), and the systemic inflammatory marker C-reactive protein (CRP), as well as depression and neuroticism, in clinically anxious and non-anxious adults. Compared with non-anxious participants, clinically anxious participants exhibited significantly lower levels of morning cortisol and significantly higher levels of IL-6, independent of age, sex, and depressive symptoms. These group differences were robust when controlling for neuroticism. Conversely, the groups had equivalent levels of CRP in all analyses. Results are indicative of anxiety-specific effects on inflammatory activity, and highlight a pathway by which anxiety may increase risk for inflammatory diseases.

  13. Preventing Wounds from Healing: Clinical Prevalence and Relationship to Borderline Personality

    OpenAIRE

    Sansone, Randy A.; Sansone, Lori A.

    2013-01-01

    In medico-economic studies, wound care has been shown to be expensive but is seemingly unavoidable given an aging population and the high community rates of diabetes and obesity. Astonishingly, however, some impaired wound resolution is intentional or purposeful. According to our review of seven clinical samples, the prevalence of preventing wounds from healing varies from 0.8 percent in a cardiac-stress-testing sample to 13.3 percent in a psychiatric inpatient sample. These variations in pre...

  14. An investigation of the relationship between functional impairment and autistic traits in a clinical population

    OpenAIRE

    Varrall, R.

    2011-01-01

    Aims: Based on theories of dimensionality and fractionation of the autistic triad, this study investigates the role of autistic traits in adaptive functioning. The suitability of current diagnostic thresholds and classification criteria are explored with particular interest in partial and mild sub-threshold autistic presentations. Method: Seventy-two young people (mean age = 11.03 years), referred for assessment at a specialist autism spectrum disorder (ASD) clinic were administered the Vinel...

  15. Relationship between oral cancer and implants: clinical cases and systematic literature review

    OpenAIRE

    Jané-Salas, Enrique; López-López, José; Roselló-Llabrés, Xavier; Rodríguez-Argueta, Oscar-Francisco; Chimenos-Küstner, Eduardo

    2011-01-01

    The use of implants for oral rehabilitation of edentulous spaces has recently been on the increase, which has also led to an increase in complications such as peri-implant inflammation or periimplantitis. Chronic inflammation is a risk factor for developing oral squamous cell carcinoma (OSCC). Objectives: To review the literature of cases that associate implant placement with the development of oral cancer. Study design: We present two clinical cases and a systematic review of literature publ...

  16. The Relationship between Stress Levels and Biological Responses in a Clinical Nursing Practicum

    OpenAIRE

    Chikamura, Chiho; Iida, Tadayuki; Ishizaki, Fumiko; Aoi, Satomi; Kobayashi, Toshio; Kataoka, Tsuyoshi

    2008-01-01

    We evaluated the association between the stress levels and biological responses of nursing students in a clinical practicum. The subjects consisted of 28 third-year nursing students at the nursing department of College A. The degree of stress was evaluated using the Japanese version of the State Trait Anxiety Inventory (STAI). As parameters of biological responses, serum estrogen, salivary cortisol, and salivary IgA were measured. These measurements were performed twice (before and during the...

  17. Relationship Between Patient-Reported Outcomes and Clinical Outcomes in Patients With Morquio A Syndrome

    Directory of Open Access Journals (Sweden)

    Christina Lampe MD

    2015-04-01

    Full Text Available This cross-sectional analysis assessed the correlation between patient-reported outcomes (PROs and clinical outcomes in 24 German patients with Morquio A. Clinical outcomes included 6-minute walk test (6MWT, 3-minute stair climb (3MSC test, and joint range of motion as measures for endurance/mobility, forced vital capacity (FVC and maximum voluntary ventilation (MVV as measures for respiratory function, and height as an important manifestation. The PROs included the EuroQoL (EQ 5D-5L (EQ5D-5L, to measure health-related QoL (HRQoL, and patients’ rating of their ability to walk, climb, or breathe. In adults, endurance and pulmonary function measures and height showed strong and statistically significant correlation with the patients’ EQ5D-5L (6MWT: R = .884, 3MSC test: R = .852, FVC: R = .815, MVV: R = .825, height: R = .842. The adult patients’ rating of their ability to walk and climb also correlated strongly with 6MWT (R = .839 and 3MSC test (R = .700 results. Improvements in these clinical outcomes may be robust surrogate parameters of a better EQ5D-5L/HRQoL in patients with Morquio A.

  18. Relationship between the expression of matrix metalloproteinase-9 and angiogenesis in glioma and its clinical significance

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Objective To explore the role and significance of matrix metalloproteinase-9(MMP-9)in angiogenesis through observing the relationship between the expression of MMP-9 and microvessel density(MVD)in glioma.Methods The expressions of MMP-9 and CD34 in 10 cases of normal brain tissues and 58 cases of glioma(14 cases of grade Ⅰ,20 cases of grade Ⅱ,15 cases of grade Ⅲ,and 9 cases of grade Ⅳ)were detected by immunohistochemical streptavidin-peroxidase technique.The positive cells of MMP-9 and the positive microves...

  19. Relationship between clinical manifestations and pulsed-field gel profiles of Streptococcus canis isolates from dogs and cats.

    Science.gov (United States)

    Kruger, E Freya; Byrne, Barbara A; Pesavento, Patricia; Hurley, Kate F; Lindsay, Leanne L; Sykes, Jane E

    2010-11-20

    Little is known regarding the degree of genotypic relatedness between Streptococcus canis isolates from dogs and cats. The purpose of this study was to determine whether correlations existed between the genotypes of canine and feline S. canis isolates as determined using pulsed-field gel electrophoresis (PFGE) and different clinical manifestations of disease. Eighty-two isolates of S. canis were examined that had been collected from dogs and cats presenting to the University of California, Davis Veterinary Medical Teaching Hospital (VMTH) between 1998 and 2005. Associated clinical manifestations included sepsis, otitis, pyometra, skin infections, necrotizing fasciitis, respiratory disease, and urinary tract infections. In addition, 9 feline isolates from a southern California shelter that experienced an outbreak of S. canis infection manifesting as necrotizing fasciitis and death were examined. Bacterial isolates were characterized by PFGE analysis using the restriction enzyme SmaI. The relationships between banding patterns were analyzed using gel analysis software combined with visual interpretation. The feline shelter isolates of S. canis were 99% similar in bacterial PFGE profile. The remainder of samples had less than 80% similarity in PFGE banding patterns. The relatedness of the PFGE profile in the feline shelter isolates suggested a clonal origin. In the isolates from the VMTH population, there was no relationship between specific disease manifestations and PFGE profile. PFGE typing does not appear to be useful for identifying isolates associated with specific disease presentations; however may be more useful to identify outbreaks of S. canis infections or to detect clonal populations in outbreaks. PMID:20605376

  20. Relationship between energy expenditure, nutritional status and clinical severity before starting enteral nutrition in critically ill children.

    Science.gov (United States)

    Botrán, Marta; López-Herce, Jesús; Mencía, Santiago; Urbano, Javier; Solana, Maria José; García, Ana; Carrillo, Angel

    2011-03-01

    The objective of the present study was to investigate the relationship between energy expenditure (EE), biochemical and anthropometric nutritional status and severity scales in critically ill children. We performed a prospective observational study in forty-six critically ill children. The following variables were recorded before starting nutrition: age, sex, diagnosis, weight, height, risk of mortality according to the Paediatric Risk Score of Mortality (PRISM), the Revised Paediatric Index of Mortality (PIM2) and the Paediatric Logistic Organ Dysfunction (PELOD) scales, laboratory parameters (albumin, total proteins, prealbumin, transferrin, retinol-binding protein, cholesterol and TAG, and nitrogen balance) and EE measured by indirect calorimetry. The results showed that there was no relationship between EE and clinical severity evaluated using the PRISM, PIM2 and PELOD scales or with the anthropometric nutritional status or biochemical alterations. Finally, it was concluded that neither nutritional status nor clinical severity is related to EE. Therefore, EE must be measured individually in each critically ill child using indirect calorimetry.

  1. Mothers' and Fathers' Ratings of Family Relationship Quality: Associations with Preadolescent and Adolescent Anxiety and Depressive Symptoms in a Clinical Sample

    Science.gov (United States)

    Queen, Alexander H.; Stewart, Lindsay M.; Ehrenreich-May, Jill; Pincus, Donna B.

    2013-01-01

    This study examined the independent associations among three family relationship quality factors--cohesion, expressiveness, and conflict--with youth self-reported depressive and anxiety symptoms in a clinical sample of anxious and depressed youth. Ratings of family relationship quality were obtained through both mother and father report. The…

  2. [Conflicts of interest in clinical practice. Ethical analysis of some relationships with the pharmaceutical industry].

    Science.gov (United States)

    Salas, Sofía P; Osorio F, Marcial; Vial C, Pablo; Rehbein V, Ana María; Salas A, Camila; Beca I, Juan Pablo

    2006-12-01

    Sometimes, the prescription practice of physicians can be influenced by factors that are not related to scientific evidence due to the appearance of several conflicts of interest. These conflicts cause social concern and have prompted actions to regulate the ethics of individual and corporative activities related to healthcare. We analyzed the ethical problems involved in the physician-industry relationship. For this purpose, we considered as the main actors related to this problem, the pharmaceutical industry and their marketing strategies, medical doctors and the independence and objectivity that should guide prescriptions and, finally, patients and their right to receive prescriptions based on scientific evidence. From the point of view of the Bioethics principles, Beneficence would not be respected when gifts or other donations received from the industry affect doctor's independence. Non Maleficence principle could be jeopardized if there is an increased risk of treatment failure and finally Justice could be altered if there is a cost increase for either patients or health institutions. As a conclusion, we consider that the presence of conflicts of interest in the relationship of physicians with the pharmaceutical industry is an important ethical problem. In consequence, this group endorses the recommendations of the Chilean Association of Medical Scientific Societies and advices to include ethical guidelines on this topic in the curriculum of medical schools. PMID:17277877

  3. The relationship between temperament and autistic traits in a non-clinical students sample.

    Directory of Open Access Journals (Sweden)

    Ewa Pisula

    Full Text Available Since temperament affects the development of social behaviours and interpersonal relations, the possible links between autistic traits and temperament are of particular interest. The purpose of the study was to explore the relationships between autistic traits and temperamental characteristics in the framework of the Regulative Temperament Theory by Strelau, and the Emotionality, Activity and Sociability theory by Buss and Plomin, with particular emphasis on gender differences. The Autism Spectrum Quotient (AQ, Formal Characteristics of Behaviour--Temperament Inventory and Temperament Survey for Adults were administered. The participants were 593 university students, including 364 females and 229 males. Results showed positive correlations between autistic traits and Emotional Reactivity, Perseveration, Distress, Fear and Anger, and negative correlations with Activity, Briskness, Endurance and Sociability. The results of multiple regression analyses involving the Autism Spectrum Quotient score as a dependent measure were different for females and males. Results of exploratory PCA analysis showed that AQ score, Sociability and Activity loaded one factor (with AQ loading being opposite to two others. High AQ scorers demonstrated higher Emotional Reactivity, Perseveration, Distress and Anger, and lower Briskness, Endurance, Activity and Sociability as compared to norms for the general population. In this study we showed that temperament measures were able to identify items that correlated in parts with autistic traits, while other items were obverse. The relationships between temperament and autistic traits differ slightly between genders. We assume that with regard to the broader autism phenotype, temperaments might be helpful in characterizing healthy control samples.

  4. The relationship between temperament and autistic traits in a non-clinical students sample.

    Science.gov (United States)

    Pisula, Ewa; Kawa, Rafał; Danielewicz, Dorota; Pisula, Wojciech

    2015-01-01

    Since temperament affects the development of social behaviours and interpersonal relations, the possible links between autistic traits and temperament are of particular interest. The purpose of the study was to explore the relationships between autistic traits and temperamental characteristics in the framework of the Regulative Temperament Theory by Strelau, and the Emotionality, Activity and Sociability theory by Buss and Plomin, with particular emphasis on gender differences. The Autism Spectrum Quotient (AQ), Formal Characteristics of Behaviour--Temperament Inventory and Temperament Survey for Adults were administered. The participants were 593 university students, including 364 females and 229 males. Results showed positive correlations between autistic traits and Emotional Reactivity, Perseveration, Distress, Fear and Anger, and negative correlations with Activity, Briskness, Endurance and Sociability. The results of multiple regression analyses involving the Autism Spectrum Quotient score as a dependent measure were different for females and males. Results of exploratory PCA analysis showed that AQ score, Sociability and Activity loaded one factor (with AQ loading being opposite to two others). High AQ scorers demonstrated higher Emotional Reactivity, Perseveration, Distress and Anger, and lower Briskness, Endurance, Activity and Sociability as compared to norms for the general population. In this study we showed that temperament measures were able to identify items that correlated in parts with autistic traits, while other items were obverse. The relationships between temperament and autistic traits differ slightly between genders. We assume that with regard to the broader autism phenotype, temperaments might be helpful in characterizing healthy control samples.

  5. Detangling complex relationships in forensic data: principles and use of causal networks and their application to clinical forensic science.

    Science.gov (United States)

    Lefèvre, Thomas; Lepresle, Aude; Chariot, Patrick

    2015-09-01

    The search for complex, nonlinear relationships and causality in data is hindered by the availability of techniques in many domains, including forensic science. Linear multivariable techniques are useful but present some shortcomings. In the past decade, Bayesian approaches have been introduced in forensic science. To date, authors have mainly focused on providing an alternative to classical techniques for quantifying effects and dealing with uncertainty. Causal networks, including Bayesian networks, can help detangle complex relationships in data. A Bayesian network estimates the joint probability distribution of data and graphically displays dependencies between variables and the circulation of information between these variables. In this study, we illustrate the interest in utilizing Bayesian networks for dealing with complex data through an application in clinical forensic science. Evaluating the functional impairment of assault survivors is a complex task for which few determinants are known. As routinely estimated in France, the duration of this impairment can be quantified by days of 'Total Incapacity to Work' ('Incapacité totale de travail,' ITT). In this study, we used a Bayesian network approach to identify the injury type, victim category and time to evaluation as the main determinants of the 'Total Incapacity to Work' (TIW). We computed the conditional probabilities associated with the TIW node and its parents. We compared this approach with a multivariable analysis, and the results of both techniques were converging. Thus, Bayesian networks should be considered a reliable means to detangle complex relationships in data.

  6. Comorbidity of Anxiety Disorders and Substance Abusewith Bipolar Mood Disorders and Relationship with ClinicalCourse

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    Ali Reza Shafiee-Kandjani

    2009-12-01

    Full Text Available "n Objective: Patients with bipolar mood disorder constitute a relatively large number of individuals hospitalized in psychiatric hospitals. This disorder is highly co-morbid with other psychiatric disorders and may effect their clinical course. The goal of this study was to determine the co-occurrence rate of anxiety disorders and substance abuse with bipolar mood disorders and their impact on clinical course. "n Methods: 153 bipolar patients (type I were selected among the hospitalized patients at Razi Psychiatric Hospital in Tabriz, Iran, from September 2007 to October 2008 through convenience sampling method. The participants were evaluated by a structured clinical interview based on DSM-IV criteria (SCID, Hamilton Rating Scale for Depression (HRSD and Young Mania Rating Scale (YMRS. Results: Co-morbidity of anxiety disorders was 43% . Occurrence of anxiety disorders was 26% for obsessive-compulsive disorder, 24.8% for generalized anxiety disorder, 3.9% for phobia and 2% for panic disorder. Co-morbidity of substance abuse was 7.2% and the highest occurrence of substance abuse was 5.2% for alcoholism and 3.9% for opium. No significant difference was observed between the severity of disease and duration of hospitalization in bipolar patients with or without anxiety disorder. The severity of disease and duration of hospitalization in bipolar patients with substance abuse was higher compared to bipolar patients without substance abuse (P<0.05. "nConclusions: This study suggests that there is a high co-morbidity between anxiety disorders and substance abuse with bipolar disorder. Further, this study suggests that co-occurrence of substance abuse disorder with bipolar disorder increases the severity of the disease and duration of hospitalization.

  7. Spectral analysis of systemic and cerebral cardiovascular variabilities in preterm infants: relationship with clinical risk index for babies (CRIB)

    International Nuclear Information System (INIS)

    Frequency spectrum analysis of circulatory signals has been proposed as a potential method for clinical risk assessment of preterm infants by previous studies. In this study, we examined the relationships between various spectral measures derived from systemic and cerebral cardiovascular variabilities and the clinical risk index for babies (CRIB II). Physiological data collected from 17 early low birth weight infants within 1–3 h after birth were analysed. Spectral and cross-spectral analyses were performed on heart rate variability, blood pressure variability and cerebral near-infrared spectroscopy measures such as oxygenated and deoxygenated haemoglobins (HbO2 and HHb) and tissue oxygenation index (TOI). In addition, indices related to cardiac baroreflex sensitivity and cerebral autoregulation were derived from the very low, low- and mid-frequency ranges (VLF, LF and MF). Moderate correlations with CRIB II were identified from mean arterial pressure (MAP) normalized MF power (r = 0.61, P = 0.009), LF MAP–HHb coherence (r = 0.64, P = 0.006), TOI VLF percentage power (r = 0.55, P = 0.023) and LF baroreflex gain (r = −0.61, P = 0.01 after logarithmic transformation), with the latter two parameters also highly correlated with gestational age (r = −0.75, P = 0.0005 and r = 0.70, P = 0.002, respectively). The relationships between CRIB II and various spectral measures of arterial baroreflex and cerebral autoregulation functions have provided further justification for these measures as possible markers of clinical risks and predictors of adverse outcome in preterm infants

  8. Temporary brittle bone disease: relationship between clinical findings and judicial outcome

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    Colin R. Paterson

    2011-10-01

    Full Text Available There is a wide differential diagnosis for the child with unexplained fractures including non-accidental injury, osteogenesis imperfecta and vitamin D deficiency rickets. Over the last 20 years we and others have described a self-limiting syndrome characterised by fractures in the first year of life. This has been given the provisional name temporary brittle bone disease. This work had proved controversial mostly because the fractures, including rib fractures and metaphyseal fractures, were those previously regarded as typical or even diagnostic of non-accidental injury. Some have asserted that the condition does not exist. Over the years 1985 to 2000 we investigated 87 such cases with fractures with a view to determining the future care of the children. In 85 of these the judiciary was involved. We examined the clinical and radiological findings in the 33 cases in which there was a judicial finding of abuse, the 24 cases in which the parents were exonerated and the 28 cases in which no formal judicial finding was made. The three groups of patients were similar in terms of demographics, age at fracturing and details of the fractures. The clinical similarities between the three groups of patients contrasts with the very different results of the judicial process.

  9. Towards generating a patient's timeline: extracting temporal relationships from clinical notes.

    Science.gov (United States)

    Nikfarjam, Azadeh; Emadzadeh, Ehsan; Gonzalez, Graciela

    2013-12-01

    Clinical records include both coded and free-text fields that interact to reflect complicated patient stories. The information often covers not only the present medical condition and events experienced by the patient, but also refers to relevant events in the past (such as signs, symptoms, tests or treatments). In order to automatically construct a timeline of these events, we first need to extract the temporal relations between pairs of events or time expressions presented in the clinical notes. We designed separate extraction components for different types of temporal relations, utilizing a novel hybrid system that combines machine learning with a graph-based inference mechanism to extract the temporal links. The temporal graph is a directed graph based on parse tree dependencies of the simplified sentences and frequent pattern clues. We generalized the sentences in order to discover patterns that, given the complexities of natural language, might not be directly discoverable in the original sentences. The proposed hybrid system performance reached an F-measure of 0.63, with precision at 0.76 and recall at 0.54 on the 2012 i2b2 Natural Language Processing corpus for the temporal relation (TLink) extraction task, achieving the highest precision and third highest f-measure among participating teams in the TLink track. PMID:24212118

  10. Relationship between Clinical and Immunological Features of Thyroid Autoimmunity and Ophthalmopathy during Pregnancy

    Directory of Open Access Journals (Sweden)

    Jack R. Wall

    2015-01-01

    Full Text Available Problem. Clinical features of Graves’ hyperthyroidism (GH generally improve during pregnancy and rebound in the postpartum period. It is unclear whether the ophthalmopathy that is associated with GH and, less often, Hashimoto’s thyroiditis (HT changes in parallel with the thyroid associated antibody reactions and clinical features or runs a different course. Method of Study. We retrospectively studied 19 patients with autoimmune thyroid disease over 22 pregnancies: 9 pregnancies with GH and 13 with HT. Ophthalmopathy was defined by NOSPECS class. Results. Thyroid peroxidase (TPO and thyroglobulin (Tg antibody titres decreased during pregnancy and rose in the postpartum period. During pregnancy, 5 patients with GH and 4 patients with HT developed mild ophthalmopathy and two patients with GH and HT developed new upper eyelid retraction (UER. In the postpartum period, eye scores improved in 3 patients with GH and 3 with HT, remained stable in two and 5 patients, respectively, and worsened in 2 patients with GH and one with HT. Conclusions. In patients with mild to moderate eye signs associated with GH and HT, the orbital and thyroid reactions ran different courses during pregnancy. Since no patient had severe ophthalmopathy, we cannot draw definitive conclusions from this preliminary study.

  11. Relationship between elevated soluble CD74 and severity of experimental and clinical ALI/ARDS

    Science.gov (United States)

    Wu, Guosheng; Sun, Yu; Wang, Kang’an; Chen, Zhengli; Wang, Xingtong; Chang, Fei; Li, Ting; Feng, Ping; Xia, Zhaofan

    2016-01-01

    CD74 is expressed on the cell surface of pulmonary macrophages and contributes to macrophage migration inhibitory factor (MIF)-induced inflammatory response in acute lung injury (ALI). A circulating form of CD74 (soluble CD74, sCD74) was recently discovered in autoimmune liver disease. Using two murine ALI models and cells culture, we examined the presence of sCD74 in circulation and alveolar space and preliminarily assessed the biological function of sCD74. The concentrations of sCD74 were increased in serum and bronchoalveolar lavage fluids (BALF) of murine ALI models. The elevated levels of sCD74 in BALF positively correlated with lung permeability and inflammation. In addition, sCD74 is secreted by macrophages in response to MIF stimulation and itself can stimulate the production of inflammatory cytokines. Our clinical study confirmed some findings of basic research. Moreover, we also found Day 3 serum sCD74 levels were associated with worse clinical outcomes. In conclusion, higher serum sCD74 levels may reflect more severe lung injury and may be used to help physicians determine prognosis of acute respiratory distress syndrome (ARDS). PMID:27444250

  12. Understanding the relationship between the perceived characteristics of clinical practice guidelines and their uptake: protocol for a realist review

    Directory of Open Access Journals (Sweden)

    Grimshaw Jeremy

    2011-07-01

    Full Text Available Abstract Background Clinical practice guidelines have the potential to facilitate the implementation of evidence into practice, support clinical decision making, specify beneficial therapeutic approaches, and influence public policy. However, these potential benefits have not been consistently achieved. The limited impact of guidelines can be attributed to organisational constraints, the complexity of the guidelines, and the lack of usability testing or end-user involvement in their development. Implementability has been referred to as the perceived characteristics of guidelines that predict the relative ease of their implementation at the clinical level, but this concept is as yet poorly defined. The objective of our study is to identify guideline attributes that affect uptake in practice by considering evidence from four disciplines (medicine, psychology, management, human factors engineering to determine the relationship between the perceived characteristics of recommendations and their uptake and to develop a framework of implementability. Methods A realist-review approach to knowledge synthesis will be used to understand attributes of guidelines (e.g., its text and content and how changing these elements might impact clinical practice and clinical decision making. It also allows for the exploration of 'what works for whom, in what circumstances, and in what respects'. The realist review will be structured according to Pawson's five practical steps in realist reviews: (1 clarifying the scope of the review, (2 determining the search strategy, (3 ensuring proper article selection and study quality assessment, (4 extracting and organising data, and (5 synthesising the evidence and drawing conclusions. Data will be synthesised according to a two-stage analysis: (1 we will extract and define all relevant guideline attributes from the different disciplines, then create a shortlist of unique attributes and investigate their relationships with

  13. Clinical study of the relationship between arteriosclerosis obliterans (ASO) and cerebral infarction

    International Nuclear Information System (INIS)

    To clarify the relationship between arteriosclerosis obliterans (ASO) and cerebral infarction (CI), brain CT was performed and the risk factors for atherosclerosis were assessed. Thirty-five male and 5 female patients with intermittent claudication and/or leg ulceration were angiographically diagnosed as having ASO. According to CT findings, these patients were divided into three groups [no low-density areas (NLDA), hemorrhage, and infarction (CI)]. CI was subdivided as lacunar, cortical, and watershed infarction. Thirteen patients were in the NLDA group and 26 in the CI group (17 lacunar, 3 cortical and 6 mixed infarcts), indicating a CI incidence of 65%. Comparing the risk factors of the CI group with those of the NLDA group, hypertension (53.8%), diabetes (34.6%), and cigarette smoking (69.2%) was often seen in the CI group, although hypercholesterolemia (53.8%) and ischemic heart disease (42.3%) was the same in both groups. Multivariate analysis revealed that smoking had the strongest effect on the occurrence of CI in ASO patients. Furthermore, the number of combined risk factors (hypertension, diabetes, smoking, hypercholesterolemia) had a significant positive correlation with cortical infarction. As to the chronological relationship between the onset of ASO and CI, CI was present in 14 of 27 ASO patients on CT when the ischemic leg symptoms appeared, while symptomatic cortical infarction preceded ASO in 5 patients. CI patients increased gradually over a decade to 26 out of 40, among whom 16 patients with lacunae had silent infarcts. These findings suggested that ASO is frequently associated with CI, not only due to atherosclerosis of the main trunks of the cerebral vessels, but also due to arteriolosclerosis of the perforating arteries. (author)

  14. Performance-based quality specifications: the relationship between process critical control parameters, critical quality attributes, and clinical performance.

    Science.gov (United States)

    Short, Steven M; Cogdill, Robert P; Drennen, James K; Anderson, Carl A

    2011-04-01

    The quality of pharmaceutical products is currently evaluated through a series of tests that do not explicitly communicate the clinical consequences of product variability. A previously published risk simulation platform was used to generate quantitative estimates of inefficacy and toxicity for 288 uniform lots of extended-release theophylline tablets displaying various levels of content uniformity and dissolution variability. These data were used to evaluate the univariate specifications utilized in the United States Pharmacopeia (USP) and . Simulation revealed that the specifications are too lenient for content uniformity, both in terms of inefficacy and toxicity, whereas the criteria for dissolution testing are too strict for inefficacy and inaccurate for toxicity. The USP tests also failed to pinpoint the clinical interaction between content uniformity and dissolution variability. Additionally, the simulation platform was used to define the underlying relationship between product quality attributes and clinical performance. Here, content uniformity and Weibull dissolution time constants were used as inputs to the design spaces, which were conditioned on quantitative estimates of inefficacy and toxicity. This methodology enhances the information content of the design space by omitting quality surrogates (e.g., dissolution, moisture content) that are utilized in current design space practices.

  15. [Relationship between clinical symptoms and Hiragana reading ability in children with difficulties in reading and writing:usefulness of a clinical-symptoms-checklist].

    Science.gov (United States)

    Kita, Yosuke; Kobayashi, Tomoka; Koike, Toshihide; Koeda, Tatsuya; Wakamiya, Eiji; Hosokawa, Torn; Kaga, Makiko; Inagaki, Masumi

    2010-11-01

    We investigated the clinical symptoms of children with developmental dyslexia (DD) and evaluated the relationship between these symptoms and their Hiragana reading abilities. In order to detect the clinical symptoms of DD, we newly developed a clinical-symptoms-checklist (CL), which consisted of a total of 30 yes/no questions regarding symptoms linked to reading (15 questions) and writing (15 questions). Subjects were 98 Japanese school grade (1 to 9) children, aged 6 to 15 years old, with normal intelligence confirmed by the Wechsler Intelligence Test for Children (WISC-Ill) and they were divided into 2 groups according to their diagnosis. Twenty four children diagnosed as developmental dyslexia consisted the DD group, and the remaining 74 children were grouped in the non-DD group. CL showed significant construct validity (preading: a =0.82, writing: a =0.72) after deleting two questions from the originals. The number of questions checked in the CL reading subcategory significantly correlated with the Hiragana reading ability of articulation time in all Hiragana reading tasks (preading ability were observed in the DD group compared to the non-DD group. Receiver Operating Characteristics (ROC) analysis indicated that these two groups could be discriminated by the CL and the results of the reading task, and both sensitivity and specificity rate were approximately 80%. It was suggested that 7 or more positive checks in the CL and 2 or more abnormal scores in the reading tasks might discriminate DD from other conditions which cause difficulties in reading and writing in Japanese children.

  16. Relationship of premenstrual syndrome and premenstrual dysphoric disorder with major depression: Relevance to clinical practice

    Directory of Open Access Journals (Sweden)

    Susanta Kumar Padhy

    2015-01-01

    Full Text Available Background: Premenstrual syndrome (PMS, premenstrual dysphoric disorder (PMDD and depressive disorder are fairly common; symptoms do overlap, often under-identified and under-emphasized, particularly in rural India. Objective: The objective was to assess the occurrence of PMS and PMDD in a sample of students and staff of a nursing college and to find their correlation with depression. Materials and Methods: A prospective cohort study; Tertiary Care Hospital in Rural India (Wardha, Maharashtra; 118 female nursing students or staff aged between 18 and 40 years, who were likely to stay within the institution for the study period. The participants were rated on Penn daily symptom report prospectively for a period of 3-month. Those who scored positive were applied diagnostic and statistical manual of mental disorders, 4 th edition, text revision (DSM-IV TR criteria for PMDD; and were applied primary care evaluation of mental disorders depression screening followed by DSM-IV TR criteria for depression. Severity of depression was measured using Hamilton Depression Rating Scale. Results: Main outcome measures were frequency and severity of depression in individuals with PMS and PMDD and their clinical and sociodemographic correlation. The age range of the sample was 18-37 years. Some PMS symptoms were observed in 67%; diagnosis of PMDD in 10%; depressive symptoms in 28% of the sample. 46.4% of those with depressive symptoms had major depression. The diagnosis of major depression was significantly associated with the severity of PMS symptoms as well as the presence of PMDD. Conclusion: Premenstrual syndrome is present in a substantial proportion of young females. Concurrent depression is increased by the severity of PMS symptoms and the presence of PMDD. Gynecologist needs to screen such subjects for depression and refer to mental-health professional early, in routine clinical practice.

  17. Clinical presentation and early care relationships in 'poor-me' and 'bad-me' paranoia.

    Science.gov (United States)

    Morris, Emma; Milner, Philip; Trower, Peter; Peters, Emmanuelle

    2011-06-01

    OBJECTIVE. To test the proposal that 'poor-me' (PM) and 'bad-me' (BM) paranoia can be differentiated in terms of (1) current emotional experience and presence of grandiose delusions and (2) early caregiving and threats to self-construction. METHOD. Participants experiencing persecutory delusions were separated into PM (N= 21) and BM (N= 15) groups on the basis of perceived deservedness of the persecution. The groups were compared on measures examining grandiose delusions, shame and depression, parental care, and threats of alienation and insecurity. RESULTS. As predicted, BM patients scored higher on shame and depression, and lower on grandiose delusions, than PM patients. BM patients reported higher levels of parental overprotection, but PM patients were not characterized by neglect, and the groups did not differ in type of threat to self-construction. Conclusion. The two paranoia types were differentiated on symptomatic and emotional presentation, but predicted differences in early relationships and self-construction were not fully supported.

  18. Case-control approach application for finding a relationship between candidate genes and clinical mastitis in Holstein dairy cattle.

    Science.gov (United States)

    Bagheri, Masoumeh; Moradi-Sharhrbabak, M; Miraie-Ashtiani, R; Safdari-Shahroudi, M; Abdollahi-Arpanahi, R

    2016-02-01

    Mastitis is a major source of economic loss in dairy herds. The objective of this research was to evaluate the association between genotypes within SLC11A1 and CXCR1 candidate genes and clinical mastitis in Holstein dairy cattle using the selective genotyping method. The data set contained clinical mastitis records of 3,823 Holstein cows from two Holstein dairy herds located in two different regions in Iran. Data included the number of cases of clinical mastitis per lactation. Selective genotyping was based on extreme values for clinical mastitis residuals (CMR) from mixed model analyses. Two extreme groups consisting of 135 cows were formed (as cases and controls), and genotyped for the two candidate genes, namely, SLC11A1 and CXCR1, using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), respectively. Associations between single nucleotide polymorphism (SNP) genotypes with CMR and breeding values for milk and protein yield were carried out by applying logistic regression analyses, i.e. estimating the probability of the heterogeneous genotype in the dependency of values for CMR and breeding values (BVs). The sequencing results revealed a novel mutation in 1139 bp of exon 11 of the SLC11A1 gene and this SNP had a significant association with CMR (P G and these genotypes had significant relationships with CMR. Overall, the results showed that SLC11A1 and CXCR1 are valuable candidate genes for the improvement of mastitis resistance as well as production traits in dairy cattle populations.

  19. Relationship between clinical factors and severity of esophageal candidiasis according to Kodsi's classification.

    Science.gov (United States)

    Asayama, N; Nagata, N; Shimbo, T; Nishimura, S; Igari, T; Akiyama, J; Ohmagari, N; Hamada, Y; Nishijima, T; Yazaki, H; Teruya, K; Oka, S; Uemura, N

    2014-04-01

    Severe Candida esophagitis (CE) may lead to development of strictures, hemorrhage, esophagotracheal fistula, and a consequent decrease in quality of life. Although the severity of CE has been classified based on macroscopic findings on endoscopy, the clinical significance remains unknown. The aim of the study was to elucidate the predictive clinical factors for endoscopic severity of CE. Patients who underwent upper endoscopy and answered questionnaires were prospectively enrolled. Smoking, alcohol, human immunodeficiency virus (HIV) infection, diabetes mellitus, chronic renal failure, liver cirrhosis, systemic steroids use, proton pump inhibitor use, H2 blocker use, and gastrointestinal (GI) symptoms were assessed on the same day of endoscopy. GI symptoms including epigastric pain, heartburn, reflux, hunger cramps, nausea, dysphagia, and odynophagia were assessed on a 7-point Likert scale. Endoscopic severity was classified as mild (Kodsi's grade I/II) or severe (grade III/IV). Of 1855 patients, 71 (3.8%) were diagnosed with CE (mild, n = 48; severe, n = 23). In the CE patients, 50.0% (24/48) in the mild group and 23.1% (6/23) in the severe group did not have any GI symptoms. In HIV-infected patients (n = 17), a significant correlation was found between endoscopic severity and declining CD4 cell count (Spearman's rho = -0.90; P < 0.01). Multivariate analysis revealed that GI symptoms (odds ratio [OR], 3.32) and HIV infection (OR, 3.81) were independently associated with severe CE. Patients in the severe group experienced more epigastric pain (P = 0.02), reflux symptoms (P = 0.04), dysphagia (P = 0.05), and odynophagia (P < 0.01) than those in the mild group. Of the GI symptoms, odynophagia was independently associated with severe CE (OR 9.62, P = 0.02). In conclusion, the prevalence of CE in adults who underwent endoscopy was 3.8%. Silent CE was found in both mild and severe cases. Endoscopic severity was associated with

  20. The reinforcing effect of exercise in anorexia nervosa: Clinical correlates and relationship to outcome.

    Science.gov (United States)

    Gianini, Loren M; Klein, Diane A; Call, Christine; Mayer, Laurel; Foltin, Richard W; Walsh, B Timothy; Wang, Yuanjia; Wu, Peng; Attia, Evelyn

    2016-01-01

    The purpose of the current study was to examine the relative reinforcing effect of exercise compared to a non-monetary alternative reinforcer (leisure activity), and to money, before and after weight restoration in an inpatient population with anorexia nervosa (AN). Sixty-two inpatients with AN completed a progressive ratio (PR) task to earn exercise, leisure activities, or cash at low weight and after weight restoration. Measures of pathology and motivation to exercise were completed and post-treatment discharge weights were collected. Patients worked harder for exercise at low weight than after weight restoration (df = 46, t = 5.50, p exercise (low weight: r = 0.31, weight restored: r = 0.36, p exercise among individuals with AN via a PR task does not appear valuable in assessing clinical severity or outcome. Other, simpler, self-report measures of commitment to exercise may have greater value in assessing these outcomes. PMID:27348805

  1. The relationship between organizational culture and implementation of clinical practice guidelines: a narrative review.

    Science.gov (United States)

    Dodek, Peter; Cahill, Naomi E; Heyland, Daren K

    2010-01-01

    The context in which critical care providers work has been shown to be associated with adherence to recommendations of clinical practice guidelines (CPGs). Consideration of contextual factors such as organizational culture may therefore be important when implementing guidelines. Organizational culture has been defined simply as "how things are around here" and encompasses leadership, communication, teamwork, conflict resolution, and other domains. This narrative review highlights the results of recent quantitative and qualitative studies, including studies on adherence to nutrition guidelines in the critical care setting, which demonstrate that elements of organizational culture, such as leadership support, interprofessional collaboration, and shared beliefs about the utility of guidelines, influence adherence to guideline recommendations. Outside nutrition therapy, there is emerging evidence that strategies focusing on organizational change (eg, revision of professional roles, interdisciplinary teams, integrated care delivery, computer systems, and continuous quality improvement) can favorably influence professional performance and patient outcomes. Consequently, future interventions aimed at implementing nutrition guidelines should aim to measure and take into account organizational culture, in addition to considering the characteristics of the patient, provider, and guideline. Further high quality, multimethod studies are required to improve our understanding of how culture influences guideline implementation, and which organizational change strategies might be most effective in optimizing nutrition therapy. PMID:21097767

  2. A clinical study of the relationship between crowding of teeth, plaque and gingival condition.

    Science.gov (United States)

    Ingervall, B; Jacobsson, U; Nyman, S

    1977-08-01

    A clinical trial was undertaken to assess whether crowded teeth were more likely to accumulate plaque and develop gingivitis than non-crowded teeth. A tooth was considered crowded if it was displaced by 2 mm and/or rotated 15 degrees or more from the normal position in the arch. The material consisted of 50 dental students aged 21 to 32 years. An initial examination comprised assessment of Plaque Index, Gingival Index and pocket depths. After this examination the subjects refrained from using interdental cleaning aids but continued with their normal toothbrushing for 40 days. After re-examination they were instructed in the effective use of dental floss. A final examination was carried out after 140 days. At the start of the trial no difference was found in regard to the Plaque Index between crowded and non-crowded teeth. The Gingival Index for growded front teeth, but not for crowded premolars, was somewhat higher than for the corresponding controls. The cessation of interdental cleaning resulted in a similar increase in plaque accumulation and gingival inflammation in both non-crowded and crowded teeth. The use of dental floss for approximal tooth cleaning resulted in a similar decrease in the Plaque- and Gingival Indices for both types of teeth. The results demonstrate that in a group of young adults, crowding of teeth (1) did not favour plaque accumulation on approximal tooth surfaces and (2) influenced the degree of gingival inflammation only to a minor extent.

  3. Nicotine dependence in the mental disorders, relationship with clinical indicators, and the meaning for the user

    Directory of Open Access Journals (Sweden)

    Renata Marques de Oliveira

    2014-08-01

    Full Text Available OBJECTIVE: to identify the degree of nicotine dependence among patients with schizophrenia and other mental disorders hospitalized in a general hospital, correlating these indices with clinical indicators and the meaning for the user.METHOD: the study was performed in the psychiatric unit of a general hospital, interviewing 270 patients with mental disorders using a questionnaire and the application of the Fagerstrom test. A descriptive statistical analysis of the data and thematic analysis of the content were performed.RESULTS: among the 270 patients with mental disorders, 35.6% were smokers; of whom, 53.2% presented high or very high nicotine dependence. Of the 96 smokers, 32 (33.3% were schizophrenic, among whom, 59.4% presented high or very high dependence. Higher levels of dependence were also found among the 59 elderly people (61.5% and 60 subjects with somatic comorbidities (62.5%. Meanings of smoking for the subjects: helps to forget problems and face daily conflicts; alleviates side effects of the medications; self-control; distraction; part of life.CONCLUSION: more intense tobacco dependence among schizophrenic patients is justified due to it helping them to cope with the difficulties of the disease. Nurses occupy a strategic position in the care.

  4. Relationship between Quantified Instrumental Swallowing Examination and Comprehensive Clinical Swallowing Examination.

    Science.gov (United States)

    Oh, Jong-Chi; Park, Ji-Hyuk; Jung, Min-Ye; Yoo, Eun-Young; Chang, Ki-Yeon; Lee, Teak-Young

    2016-03-01

    The aim of this study was to identify the correlation between the Mann Assessment of Swallowing Ability (MASA) and the Videofluoroscopic Dysphagia Scale (VDS) to investigate the applicability of the MASA as a follow-up test of swallowing function. Criterion validity was assessed for MASA results versus VDS scores of tests administered to 54 patients who had a stroke and dysphagia. A significant correlation was found between the MASA and the VDS (correlation coefficient = -0.509). In analyses of test-re-test reliability and inter-rater reliability of the scoring scale, intraclass correlation coefficients (2, 1) were high (0.98, 0.99). In conclusion, the results of the present study indicate that the MASA holds adequate clinical test-re-test and inter-rater reliabilities and criterion validity for measuring the swallowing abilities of Korean patients who had a stroke and dysphagia. The MASA could contribute to more systematic management of swallowing problems and efficient therapeutic service.

  5. Relationship between imaging and pathological features and clinical factors in surgical cases of temporal lobe epilepsy

    Energy Technology Data Exchange (ETDEWEB)

    Uesugi, Hideji; Matsuda, Hiroshi; Onuma, Teiichi [National Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, Tokyo (Japan); Shimizu, Hiroyuki; Arai, Nobutaka; Nakayama, Hiroshi; Maehara, Taketoshi; Yanashita, Akira

    1998-03-01

    The relationships between imaging, pathology and presumed causes in surgical cases of temporal lobe epilepsy (TLE) was studied. The subject was 62 patients. MRI, PET and SPECT were performed. Hematoxylin and eosin was used for pathological judgement. On MRI, mesial temporal sclerosis (MTS) was detected in 48 of 52 patients (92%); 32 (62%) had high-signal intensity on T2-weighted images; 31 (60%) had atrophy {l_brace}23 (44%) had high-signal intensity on T2+atrophy{r_brace}; 5 (10%) had calcified lesions; and 2 (4%) had cystic lesions. On PET and SPECT, abnormal cerebral blood flow was noted in 33 of 36 (92%). On pathological findings (61 cases), Ammon`s horn sclerosis (AHS), tumors, gliosis in lateral temporal and meningeal inflammatory finding were detected in 42 (69%), 10 (23%) and 8 (13%) cases, respectively, whereas 2 showed no abnormalities. The 2 patients with normal pathology showed both high-signal intensity and atrophy on MRI. The presumed causes of TLE were encephalitis/meningitis and/or suspected of these diseases in 15 patients (24%), injuries at birth in 5 (8%), and none in 42 (68%). The presumed causes in the 43 patients with AHS were encephalitis/meningitis in 11, injuries at birth in 3, and none in 29. Of the 15 patients in whom encephalitis/meningitis was estimated as the causes of TLE, only 6 (40%) had pathological evidence of meningeal inflammatory finding. Of the 42 patients in whom cause could not be determined, 2 had pathological evidence of meningeal inflammatory finding. (K.H.)

  6. RELATIONSHIP BETWEEN PSYCHOPATHOLOGY & SOCIO-DEMOGRAPHIC AND CLINICAL VARIABLES IN COPD AND BRONCHIAL ASTHMA: A COMPARATIVE STUDY

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    Mayank

    2014-11-01

    Full Text Available This is a cross sectional comparative case control study assessing the Relationship between psychopathology and socio demographic and clinical variables in chronic obstructive pulmonary disease (COPD and Bronchial Asthma in comparison to healthy individuals. The investigation reveals that there is psychopathology in all the three groups. The psychopathology is significantly more in patients with COPD. Psychopathology in COPD patients is related to age, duration, severity of illness and steroid medication. It is found that psychopathology in bronchial asthma patients are more than those of healthy controls but there is no significant difference. The psychopathology is significantly related to relate to age, marital status, occupational status, and smoking. Duration severity of illness and steroid medication.

  7. The Curious Case of the De-ICD: Negotiating the Dynamics of Autonomy and Paternalism in Complex Clinical Relationships.

    Science.gov (United States)

    Pullman, Daryl; Hodgkinson, Kathleen

    2016-08-01

    This article discusses the response of our ethics consultation service to an exceptional request by a patient to have his implantable cardioverter defibrillator (ICD) removed. Despite assurances that the device had saved his life on at least two occasions, and cautions that without it he would almost certainly suffer a potentially lethal cardiac event within 2 years, the patient would not be swayed. Although the patient was judged to be competent, our protracted consultation process lasted more than 8 months as we consulted, argued with, and otherwise cajoled him to change his mind, all to no avail. Justifying our at times aggressive paternalistic intervention helped us to reflect on the nature of autonomy and the dynamics of the legal, moral, and personal relationships in the clinical decision-making process. PMID:27366835

  8. Phenotypic Variation Is Almost Entirely Independent of the Host-Pathogen Relationship in Clinical Isolates of S. aureus.

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    Adrian D Land

    Full Text Available A key feature of Staphylococcus aureus biology is its ability to switch from an apparently benign colonizer of ~30% of the population to a cutaneous pathogen, to a deadly invasive pathogen. Little is known about the mechanisms driving this transition or the propensity of different S. aureus strains to engender different types of host-pathogen interactions. At the same time, significant weight has been given to the role of specific in vitro phenotypes in S. aureus virulence. Biofilm formation, hemolysis and pigment formation have all been associated with virulence in mice.To determine if there is a correlation between in vitro phenotype and the three types of host-pathogen relationships commonly exhibited by S. aureus in the context of its natural human host, we assayed 300 clinical isolates for phenotypes implicated in virulence including hemolysis, sensitivity to autolysis, and biofilm formation. For comparative purposes, we also assayed phenotype in 9 domesticated S. aureus strains routinely used for analysis of virulence determinants in laboratory settings.Strikingly, the clinical strains exhibited significant phenotypic uniformity in each of the assays evaluated in this study. One exception was a small, but significant, correlation between an increased propensity for biofilm formation and isolation from skin and soft tissue infections (SSTIs. In contrast, we observed a high degree of phenotypic variation between common laboratory strains that exhibit virulence in mouse models. These data suggest the existence of significant evolutionary pressure on the S. aureus genome and highlight a role for host factors as a strong determinant of the host-pathogen relationship. In addition, the high degree of variation between laboratory strains emphasizes the need for caution when applying data obtained in one lab strain to the analysis of another.

  9. APOE Effects on Default Mode Network in Chinese Cognitive Normal Elderly: Relationship with Clinical Cognitive Performance.

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    Haiqing Song

    Full Text Available Functional connectivity in default mode network (DMN may be changed in Alzheimer's disease (AD patients and related risk populations, such as amnestic mild cognitive impairment (aMCI patients and APOE ε4 carriers. Exploring DMN changes and related behavioral performance of APOE ε4 population might provide valuable evidence for better understanding the development of AD.Subjects were enrolled from a population-based cohort established in a multi-center study in China. Forty-nine cognitive normal individuals were enrolled after standardized cognitive evaluations, MRI examination and APOE genotyping. Regions of interest (ROI-based functional connectivity analyses were performed, and voxel-based analyses were used to validate these findings. The correlation between DMN functional connectivity and behavioral performance was further evaluated between APOE ε4ε3 and ε3ε3 carriers.Comparing to ε3ε3 carriers, functional connectivity between left parahippocampal gyrus and right superior frontal cortex (LPHC-R.Sup.F, left parahippocampal gyrus and medial prefrontal cortex (ventral (LPHC-vMPFC were significantly increased in ε4ε3 carriers, while connectivity between cerebellar tonsils and retrosplenial was decreased. LPHC-R.Sup.F connectivity was positively correlated with the changes of delay recall from baseline to follow-up (r = 0.768, p = 0.009, while LPHC-vMPFC connectivity had a positive correlation with MMSE at baseline (r = 0.356, p = 0.018, and a negative correlation with long-delayed recognition at follow-up (r = -0.677, p = 0.031. Significantly increased functional connectivity in vMPFC was confirmed in voxel-based analyses by taking LPHC as seed region.APOE ε4 carriers present both increased and decreased functional connectivity in DMN, which is correlated with clinical cognitive performances. DMN changes might be an early sign for cognitive decline.

  10. Relationship Between Blood Fibrinogen Concentration and Pathological Features of Cancer Patients: A 139-case Clinical Study

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    Da-Yong Lu

    2007-01-01

    Full Text Available Angiogenesis and coagulation are among the most consistent host responses to the presence of a malignant tissue. Pathological angiogenesis and coagulation are often occurred in patients with solid tumors, especially in the occurrence of neoplasm metastasis and as targets for anti-metastatic drugs such as antiangiogenesis agents, coagulation-mediated agents and anticancer drugs. Since fibrinogen (Fib is the most abundant and key haemostatic protein taking part in angiogenesis and coagulation, its biological and pathophysiological roles in cancer patients are intriguing. To continue foundational and translational research on Fib-related cancer pathogenesis, a phase II survey of 139 patients was carried out at the Central Hospital of Jing-An district and Shanghai University, Shanghai, China. The mean BFC of the cancer patients in this survey was overall about 35-50% greater than that in the normal population. This study showed that the mean BFC was higher in patients with long-distance metastases (N1M1 patients than in patients with no sign of long-distance metastases (N0M0 patients. Mean BFCs were 4.42 g/L (n= 21 in patients with lung cancer, 4.36 g/L, and in patients with hepatic cancer (n=5, and 4.63 g/L in patients with stomach cancer (n=8, all higher than the average value of the cancer patients overall (4.16 g/L. However, patients with bowel and colon cancers 3.79 g/L (n=16 showed lower than them. BFC levels increased with increasing cancer duration (latency > 1 year. There was a slight decrease in BFC after one or two treatment cycles, but a more marked decrease after surgery. We propose that the BFC level in cancer patients may be influenced by and related to many aspects of cancer progression such as metastatic conditions, tumor origins, patient’s pathological stage and disease latency. As an important first-hand pathologic-therapeutics relationship study, it provides evidence for the potentiality of a new approach of Fib-targeted as

  11. Biofilm synthesis and its relationship with genetic characteristics in clinical methicillin-resistant staphylococci

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    Nikolaos Giormezis

    2015-09-01

    types and, among them, one major PFGE type (C consisting of 77/106 strains (72.6%. MLST identified five sequence types: ST5, ST30, ST80, ST225 and ST239. One major PFGE type (h was identified in S. haemolyticus. A clonal relationship was found concerning fnbA carriage in MRSA, ica carriage in MRSE, and antimicrobial susceptibility in both groups reinforcing the aspect of clonal expansion in hospital settings.

  12. Relationship between whole-body tumor burden, clinical phenotype, and quality of life in patients with neurofibromatosis.

    Science.gov (United States)

    Merker, Vanessa L; Bredella, Miriam A; Cai, Wenli; Kassarjian, Ara; Harris, Gordon J; Muzikansky, Alona; Nguyen, Rosa; Mautner, Victor F; Plotkin, Scott R

    2014-06-01

    Patients with neurofibromatosis 1 (NF1), NF2, and schwannomatosis share a predisposition to develop multiple nerve sheath tumors. Previous studies have demonstrated that patients with NF1 and NF2 have reduced quality of life (QOL), but no studies have examined the relationship between whole-body tumor burden and QOL in these patients. We administered a QOL questionnaire (the SF-36) and a visual analog pain scale (VAS) to a previously described cohort of adult neurofibromatosis patients undergoing whole-body MRI. One-sample t-tests were used to compare norm-based SF-36 scores to weighted population means. Spearman correlation coefficients and multiple linear regression analyses controlling for demographic and disease-specific clinical variable were used to relate whole-body tumor volume to QOL scales. Two hundred forty-five patients (142 NF1, 53 NF2, 50 schwannomatosis) completed the study. Subjects showed deficits in selected subscales of the SF-36 compared to adjusted general population means. In bivariate analysis, increased tumor volume was significantly associated with pain in schwannomatosis patients, as measured by the SF-36 bodily pain subscale (rho = -0.287, P = 0.04) and VAS (rho = 0.34, P = 0.02). Regression models for NF2 patients showed a positive relationship between tumor burden and increased pain, as measured by the SF-36 (P = 0.008). Patients with NF1, NF2, and schwannomatosis suffer from reduced QOL, although only pain shows a clear relationship to patient's overall tumor burden. These findings suggest that internal tumor volume is not a primary contributor to QOL and emphasize the need for comprehensive treatment approaches that go beyond tumor-focused therapies such as surgery by including psychosocial interventions. PMID:24664633

  13. Folie à Deux – A Clinical Case of Folie Imposée in a Mother/Child Relationship

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    Marta Nascimento

    2013-11-01

    Full Text Available Background: Even though the origin of the concept of shared delusion is not consensual, the term folie a deux was introduced in 1877 by two french researchers – Lasègue and Falret. According to the original concept, a person (inductor, cognitively dominant, develops a delusional idea that progressively imposes to a second person (induced, with whom he keeps a close relationship. The four psychopathologic subtypes known – folie imposée, folie simultanée, folie communiquée and folie induite, were described in the final of the XIX century, but its classification and conceptualization was assigned to the american researcher Gralnick (1942. Aim, materials and methods: It is intended to highlight some clinical aspects of the shared delusion disorder, its epidemiological and psycopathogenic characterization and therapeutical approach. In order to achieve it, the authors presented a clinical case report and respective non systematic literature review. Results: It is a case of shared delusion of the type folie imposée in a pair mother/son. The inductor (son suffers from bipolar disorder and asperger syndrome and shared with his mother (induced and carer a persecutory delusion. Conclusions: It is highlighted the importance of a social isolation context and close contact between both members in the genesis of the disease; it is discussed the subject of the cognitive dominance between the inductor and the induced and the implications of the separation of the pair mother/son, as primary therapeutic action.

  14. Folie à Deux – A Clinical Case of Folie Imposée in a Mother/Child Relationship

    Directory of Open Access Journals (Sweden)

    Marta Nascimento

    2012-12-01

    Full Text Available Background: Even though the origin of the concept of shared delusion is not consensual, the term folie a deux was introduced in 1877 by two french researchers – Lasègue and Falret. According to the original concept, a person (inductor, cognitively dominant, develops a delusional idea that progressively imposes to a second person (induced, with whom he keeps a close relationship. The four psychopathologic subtypes known – folie imposée, folie simultanée, folie communiquée and folie induite, were described in the final of the XIX century, but its classification and conceptualization was assigned to the american researcher Gralnick (1942. Aim, materials and methods: It is intended to highlight some clinical aspects of the shared delusion disorder, its epidemiological and psycopathogenic characterization and therapeutical approach. In order to achieve it, the authors presented a clinical case report and respective non systematic literature review. Results: It is a case of shared delusion of the type folie imposée in a pair mother/son. The inductor (son suffers from bipolar disorder and asperger syndrome and shared with his mother (induced and carer a persecutory delusion. Conclusions: It is highlighted the importance of a social isolation context and close contact between both members in the genesis of the disease; it is discussed the subject of the cognitive dominance between the inductor and the induced and the implications of the separation of the pair mother/son, as primary therapeutic action.

  15. The Relationship of Osteoporosis Risk Factors with Bone Mineral Density in Patients Admitted Our Outpatient Clinic in Trabzon

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    Münevver Serdaroğlu Beyazal

    2016-04-01

    Full Text Available Objective: Our aim was to identify the relationship of osteoporosis (OP risk factors with bone mineral density (BMD in patients admitted our outpatient clinic in Trabzon. Materials and Methods: Two hundred one patients with OP or osteopenia were included in this study. Sociodemographic characteristics of the patients were recorded and a standardized interview was employed by the researcher physician. BMD values were measured by dual energy X-ray absorptiometry at lumbar spine and femoral neck. Results: The mean age of the patients was 61.47±10.57 years (182 females/19 males. One hundred fifteen patients (57.2% were osteoporotic and 86 (42.8% were osteopenic. A significant negative correlation was found between age and femoral neck T scores. The number of pregnancies showed a significant negative correlation with lumbar T scores. Body mass index and daily tea consumption showed a negligible positive correlation with femoral neck T scores. No association was found between age at menarche, age at menopause, total lactation duration, daily calcium intake and T scores of lumbar spine and femoral neck. Conclusions: Identification of regional OP risk factors may be useful for the OP risk management of patients in clinical practice.

  16. Interfaces between electronic medical record (EMR/EHR) technology and people in American medicine: insight. imagination, and relationships in clinical practice.

    Science.gov (United States)

    Stein, Howard F

    2012-08-01

    This paper explores the contexts and relationships in which EMR/EHR technology is used in healthcare settings. It approaches the EMR/EHR as an issue in clinical ethics. The author recognizes the immense contribution that healthcare informatics makes to coordinating and integrating medical care at the level of individual physician, nurse, and institutions. At the same time the author raises a cautionary note about some unrecognized dimensions of the use and experience of the EMR/EHR. The author argues that the EMR/EHR can consciously and unconsciously become an instrument of assembly line-like physician "productivity" and "production reports" that depersonalize patient and physician alike. Construed this way, the EMR/EHR can narrow the clinician's imagination, relationships, clinical decision-making, and documentation into oversimplified, and potentially distorting, clinical narratives and categories such as fit into CPT, ICD-9, DRG, DSM-IV and other codes, EBM protocols, and clinical algorithms. By contrast, the author uses a vignette and one of his own clinical poems to illustrate the rich weave of relationship and meaning that are foreground rather than background in clinical assessment, decision-making, treatment, outcome, and satisfaction. The author concludes with a call to imaginatively use the EMR/EHR as an instrument of physician-patient communication, and to include in it and make available vital narrative data (evidence) about patient, family, culture, occupation, socioeconomic status, physician, disease, and their relationships.

  17. Relationship between linguistic functions and cognitive functions in a clinical study of Chinese patients with post-stroke aphasia

    Institute of Scientific and Technical Information of China (English)

    YU Zeng-zhi; JIANG Shu-jun; BI Sheng; LI Jun; LEI Di; SUN Li-ling

    2013-01-01

    Background There has been a long debate among scholars surrounding the relationship between language and cognition.The worldwide study of aphasia is actively exploring the function of language from cognitive point of view.This study aimed to investigate the relationship between linguistic functions and cognitive functions in a clinical study of Chinese patients with post-stroke aphasia.Methods Cognitive functions of 63 Chinese patients with aphasia following a stroke were assessed with the Chinese version of the second edition of Loewenstein Occupational Therapy Cognitive Assessment (LOTCA) battery and their linguistic functions were tested with the Western Aphasia Battery (WAB) Scale,respectively.The correlation between the results observed on the LOTCA battery and those on the WAB was analyzed.Aphasia quotient,performance quotient,cortical quotient,and linguistic function of the patients were compared.Then,each language function was analyzed by way of dependent adopt multiple regression analysis.Results The total score of 63 patients as shown on the LOTCA battery was significantly correlated with the aphasia quotient,performance quotient,and cortical quotient observed on the WAB Scale (P <0.05,P <0.01).However,the correlation between visuomotor organization under LOTCA and repeat under WAB was not significant (P >0.05).The attention of LOTCA and WAB's spontaneous speech,repeat,naming,and aphasia quotient was not relevant either (P>0.05).In addition,correlations between the results observed on the LOTCA battery and the WAB were significant (P<0.05,P <0.01).Among the significant variables finally entered into the standardized canonical discriminant functions,main factors affected the aphasia.Multiple regression analysis showed that orientation,spatial perception,and visual perception had a notable influence on aphasia quotient and naming.Orientation and thinking operation was found to have a notable influence on spontaneous speech.Spatial perception and

  18. Clinical impact of the temporal relationship between depression and type 2 diabetes: the Fremantle diabetes study phase II.

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    David G Bruce

    Full Text Available BACKGROUND: The clinical features of type 2 diabetes may differ depending on whether first depression episode precedes or follows the diagnosis of diabetes. METHODS: Type 2 patients from the observational community-based Fremantle Diabetes Study Phase II underwent assessment of lifetime depression using the Brief Lifetime Depression Scale (developed and validated for this study supplemented by information on current depression symptoms (Patient Health Questionnaire, 9-item version and use of antidepressants. Patients were categorized as never depressed (Group 1, having had depression before diabetes diagnosis (Group 2, diagnosed with depression and diabetes within 2 years of each other (Group 3 and having depression after diabetes diagnosis (Group 4. RESULTS: Of 1391 patients, 20.8% were assigned to Group 2, 6.0% to Group 3 and 14.5% to Group 4. In Group 2, depression occurred a median 15.6 years before diabetes onset at age 37.2±14.7 years. These patients had similar clinical characteristics to never depressed patients except for reduced self-care behaviours and having more symptomatic peripheral arterial disease. In Group 4, depression occurred a median 9.9 years after diabetes onset at age 59.8±13.0 years. These patients had long duration diabetes, poor glycaemic control, more intensive management and more diabetic complications. Group 4 patients had more current depression than Group 2 but were less likely to be receiving antidepressants. CONCLUSIONS/INTERPRETATION: The clinical features of depression and type 2 diabetes are heterogeneous depending on their temporal relationship. There may be corresponding differences in the pathogenesis of depression in diabetes that have implications for diagnosis and management.

  19. Interhemispheric functional connectivity and its relationships with clinical characteristics in major depressive disorder: a resting state fMRI study.

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    Li Wang

    Full Text Available BACKGROUND: Abnormalities in large-scale, structural and functional brain connectivity have been increasingly reported in patients with major depressive disorder (MDD. However, MDD-related alterations in functional interaction between the cerebral hemispheres are still not well understood. Resting state fMRI, which reveals spontaneous neural fluctuations in blood oxygen level dependent signals, provides a means to detect interhemispheric functional coherence. We examined the resting state functional connectivity (RSFC between the two hemispheres and its relationships with clinical characteristics in MDD patients using a recently proposed measurement named "voxel-mirrored homotopic connectivity (VMHC". METHODOLOGY/PRINCIPAL FINDINGS: We compared the interhemispheric RSFC, computed using the VMHC approach, of seventeen first-episode drug-naive patients with MDD and seventeen healthy controls. Compared to the controls, MDD patients showed significant VMHC decreases in the medial orbitofrontal gyrus, parahippocampal gyrus, fusiform gyrus, and occipital regions including the middle occipital gyrus and cuneus. In MDD patients, a negative correlation was found between VMHC of the fusiform gyrus and illness duration. Moreover, there were several regions whose VMHC showed significant negative correlations with the severity of cognitive disturbance, including the prefrontal regions, such as middle and inferior frontal gyri, and two regions in the cereballar crus. CONCLUSIONS/SIGNIFICANCE: These findings suggest that the functional coordination between homotopic brain regions is impaired in MDD patients, thereby providing new evidence supporting the interhemispheric connectivity deficits of MDD. The significant correlations between the VMHC and clinical characteristics in MDD patients suggest potential clinical implication of VMHC measures for MDD. Interhemispheric RSFC may serve as a useful screening method for evaluating MDD where neural connectivity is

  20. Relationship of academic courses and clinical internships to performance on the National Qualified Examination for Registered Professional Nurses (NQEX-RPN)

    OpenAIRE

    Huimin Xiao; Weiwei Wu; Yan Lin; Xuan Zhang

    2014-01-01

    Background: Success in the National Qualified Examination for Registered Professional Nurses (NQEX-RPN) is a critical issue for each nursing student and every nursing school. However, to date, little research has been conducted regarding the degree of risk for licensure failure associated with specific academic courses and clinical internships in Mainland China. Objective: This study aimed to explore the relationship of academic courses and clinical internships to performance on the NQEX-R...

  1. A Global View of the Relationships between the Main Behavioural and Clinical Cardiovascular Risk Factors in the GAZEL Prospective Cohort

    Science.gov (United States)

    Meneton, Pierre; Lemogne, Cédric; Herquelot, Eléonore; Bonenfant, Sébastien; Larson, Martin G.; Vasan, Ramachandran S.; Ménard, Joël; Goldberg, Marcel; Zins, Marie

    2016-01-01

    Although it has been recognized for a long time that the predisposition to cardiovascular diseases (CVD) is determined by many risk factors and despite the common use of algorithms incorporating several of these factors to predict the overall risk, there has yet been no global description of the complex way in which CVD risk factors interact with each other. This is the aim of the present study which investigated all existing relationships between the main CVD risk factors in a well-characterized occupational cohort. Prospective associations between 12 behavioural and clinical risk factors (gender, age, parental history of CVD, non-moderate alcohol consumption, smoking, physical inactivity, obesity, hypertension, dyslipidemia, diabetes, sleep disorder, depression) were systematically tested using Cox regression in 10,736 middle-aged individuals free of CVD at baseline and followed over 20 years. In addition to independently predicting CVD risk (HRs from 1.18 to 1.97 in multivariable models), these factors form a vast network of associations where each factor predicts, and/or is predicted by, several other factors (n = 47 with p<0.05, n = 37 with p<0.01, n = 28 with p<0.001, n = 22 with p<0.0001). Both the number of factors associated with a given factor (1 to 9) and the strength of the associations (HRs from 1.10 to 6.12 in multivariable models) are very variable, suggesting that all the factors do not have the same influence within this network. These results show that there is a remarkably extensive network of relationships between the main CVD risk factors which may have not been sufficiently taken into account, notably in preventive strategies aiming to lower CVD risk. PMID:27598908

  2. Absence of a relationship between immunophenotypic and colony enumeration analysis of endothelial progenitor cells in clinical haematopoietic cell sources

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    Turner Marc L

    2007-07-01

    Full Text Available Abstract Background The discovery of adult endothelial progenitor cells (EPC offers potential for vascular regenerative therapies. The expression of CD34 and VEGFR2 by EPC indicates a close relationship with haematopoietic progenitor cells (HPC, and HPC-rich sources have been used to treat cardiac and limb ischaemias with apparent clinical benefit. However, the laboratory characterisation of the vasculogenic capability of potential or actual therapeutic cell autograft sources is uncertain since the description of EPC remains elusive. Various definitions of EPC based on phenotype and more recently on colony formation (CFU-EPC have been proposed. Methods We determined EPC as defined by proposed phenotype definitions (flow cytometry and by CFU-EPC in HPC-rich sources: bone marrow (BM; cord blood (CB; and G-CSF-mobilised peripheral blood (mPB, and in HPC-poor normal peripheral blood (nPB. Results As expected, the highest numbers of cells expressing the HPC markers CD34 or CD133 were found in mPB and least in nPB. The proportions of CD34+ cells co-expressing CD133 is of the order mPB>CB>BM≈nPB. CD34+ cells co-expressing VEGFR2 were also most frequent in mPB. In contrast, CFU-EPC were virtually absent in mPB and were most readily detected in nPB, the source lowest in HPC. Conclusion HPC sources differ in their content of putative EPC. Normal peripheral blood, poor in HPC and in HPC-related phenotypically defined EPC, is the richest source of CFU-EPC, suggesting no direct relationship between the proposed EPC immunophenotypes and CFU-EPC potential. It is not apparent whether either of these EPC measurements, or any, is an appropriate indicator of the therapeutic vasculogenic potential of autologous HSC sources.

  3. Relationship Between Bone Minerals Density and Some Characteristics of Postmenopausal Women who Were Visiting Orthopedics Clinics - Original Investigation

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    Gülendam Karadağ

    2007-12-01

    Full Text Available Aim: Frequency of osteoporosis that depending different factors in postmenopausal women is increase. So our study was done to determine the relationship between some habits of the postmenopausal women and bone mineral density. Material and Methods: The study was done as descriptive a hospital in Gaziantep between the dates 3 July - 8 August, 2006. The comprehension of the study is all patients who applied to orthopedics clinics, and sampling consists of 70 patients who wanted to join study, and postmenopausal, hadn’t taken steroid and calcitonin treatment more than last one year. Before study, informed approwal was taken from patients and institution. Data of the study were collected using questionnaire form. Density of bone minerals was grouped according to the standarts of WHO as normal (t>-1.0, osteopenic (t0.05. Conclusion: It was seen that majority of patients didn’t make sports regularly, and the risk of having osteoporosis was higher who were getting older. For this reason, it can be suggested that to prevent osteoporosis especially in postmenopausal women necessary education should be given. (From the World of Osteoporosis 2007;13:75-9

  4. The Relationship between Apoptosis and the Expression of Proliferating Cell Nuclear Antigen and the Clinical Stages in Gastric Carcinoma

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The relationship between the apoptosis and the expression of proliferating cell nuclear antigen (PCNA) and the clinical stages in gastric cancers was studied. By using terminal deoxynucleotidyl transferase-mediated nick end labelling (TUNEL) technique and PCNA immunohistochemical staining, the apoptosis and the expression of PCNA in tissue of gastric carcinoma were assayed in situ, the index of apoptosis (AI), index of PCNA (PI) and the rate of AI/PI were calculated. AI and PI in gastric cancer tissues were (6.5±3.7) % and (49.8±15.9) % respectively, and the rate of AI/PI was 0.13±0.05, which were obviously different from those of normal gastric mucosa in paragastric cancer (P<0.01). With the advanced TNM stages of gastric carcinoma, the AI was decreased, PI was increased and the rate of AI/PI decreased in gastric carcinoma. There was significant difference in them between the gastric cancer tissues and normal gastric mucosa in pericarcinoma in TNM stage Ⅱ to Ⅳ (P<0.05). It was suggested that the decreased apoptotic cells and the increased proliferating cells were obviously related to the tumor genesis and tumor progression in gastric carcinoma. The AI, PI and the rate of AI/PI would become the prognostic factors in advanced gastric carcinoma.

  5. Relationship between alcohol consumption and clinical manifestation of patients with fatty liver:a single-center study

    Institute of Scientific and Technical Information of China (English)

    Xiu-FangWang; MinYue

    2011-01-01

    BACKGROUND: Fatty liver is a common chronic liver disease worldwide. It is associated with an increasing morbidity in China in recent years. The aim of this study was to analyze the effect of drinking alcohol on the hemoglobin and biochemical values of patients with fatty liver. METHODS: We investigated the clinical and laboratory data of 669 patients with fatty liver. Of the 669 patients, 166 consumed alcohol more than 60 g per week for at least 2 years, and 503 did not have a history of long-term alcohol consumption. We further analyzed the relationship between alcohol consumption and clinicalcharacteristicsofthesepatients. RESULTS: The values of aspartate transaminase (AST), gamma-glutamyl transpeptidase (GGT), and hemoglobin in the long-term consumption group were significantly higher than those in the non long-term consumption group (P CONCLUSION: Alcohol consumption is associated with significantly increased values of AST, GGT, and hemoglobin in patients with fatty liver, suggesting their potential roles in hepatic steatosis.

  6. m-Chlorophenylpiperazine challenge in borderline personality disorder: relationship of neuroendocrine response, behavioral response, and clinical measures.

    Science.gov (United States)

    Stein, D J; Hollander, E; DeCaria, C M; Simeon, D; Cohen, L; Aronowitz, B

    1996-09-15

    We have previously found that a subgroup of patients with impulsive personality disorders respond to m-chlorophenylpiperazine (m-CPP) administration with a distinctive spacy/high behavioral reaction and with increased cortisol responses. In this report we analyzed the relationship between behavioral and neuroendocrine responses to m-CPP in an enlarged sample of patients with borderline personality disorder (BPD). We also assessed the association of behavioral and neuroendocrine responses with clinical symptoms and with m-CPP blood levels. We found that in BPD patients the presence of a spacy/high behavioral response was significantly associated with increased prolactin and cortisol responses to m-CPP. In BPD patients increased m-CPP levels were significantly associated with neuroendocrine hypersensitivity and with a spacy/high behavioral response, while in controls increased m-CPP levels were not significantly associated with neuroendocrine hypersensitivity but were significantly associated with dysphoric behavioral responses. Taken together with previous work on m-CPP in obsessive-compulsive disorder, these results are partially consistent with the hypothesis that compulsive and impulsive symptoms fall at opposite ends of a phenomenologic and neurobiologic spectrum.

  7. Evaluating the relationship between cannabis use and IQ in youth and young adults at clinical high risk of psychosis.

    Science.gov (United States)

    Buchy, Lisa; Seidman, Larry J; Cadenhead, Kristin S; Cannon, Tyrone D; Cornblatt, Barbara A; McGlashan, Thomas H; Perkins, Diana O; Stone, William; Tsuang, Ming T; Walker, Elaine F; Woods, Scott W; Bearden, Carrie E; Mathalon, Daniel H; Addington, Jean

    2015-12-30

    Among people with psychosis, those with a history of cannabis use show better cognitive performance than those who are cannabis naïve. It is unknown whether this pattern is present in youth at clinical high risk (CHR) of psychosis. We evaluated relationships between IQ and cannabis use while controlling for use of other substances known to impact cognition in 678 CHR and 263 healthy control (HC) participants. IQ was estimated using the Vocabulary and Block Design subtests of the Wechsler Abbreviated Scale of Intelligence. Drug and alcohol use severity and frequency were assessed with the Alcohol and Drug Use Scale, and we inquired participants' age at first use. CHR were further separated into early and late age at onset of cannabis use sub-groups, and low-, moderate- and high-frequency sub-groups. No significant differences in IQ emerged between CHR or HC cannabis users vs. non-users, or between use frequency groups. CHR late-onset users showed significantly higher IQ than CHR early-onset users. Age at onset of cannabis use was significantly and positively correlated with IQ in CHR only. Results suggest that age at onset of cannabis may be a more important factor for IQ than use current use or use frequency in CHR. PMID:26626949

  8. The Relationship between Childhood Sexual Abuse, Complex Post-Traumatic Stress Disorder and Alexithymia in Two Outpatient Samples: Examination of Women Treated in Community and Institutional Clinics

    Science.gov (United States)

    McLean, Linda M.; Toner, Brenda; Jackson, Jennifer; Desrocher, Mary; Stuckless, Noreen

    2006-01-01

    Relationships between trauma variables, complex post-traumatic stress disorder (complex PTSD), affect dysregulation, dissociation, somatization, and alexithymia were studied in 70 women with early-onset sexual abuse treated in community-based private (n = 25) or clinic outpatient settings (n = 45). Measures were the Toronto Alexithymia Scale-20…

  9. Relationship between haemagglutination-inhibiting antibody titres and clinical protection against influenza: development and application of a bayesian random-effects model

    Directory of Open Access Journals (Sweden)

    Megas Françoise

    2010-03-01

    Full Text Available Abstract Background Antibodies directed against haemagglutinin, measured by the haemagglutination inhibition (HI assay are essential to protective immunity against influenza infection. An HI titre of 1:40 is generally accepted to correspond to a 50% reduction in the risk of contracting influenza in a susceptible population, but limited attempts have been made to further quantify the association between HI titre and protective efficacy. Methods We present a model, using a meta-analytical approach, that estimates the level of clinical protection against influenza at any HI titre level. Source data were derived from a systematic literature review that identified 15 studies, representing a total of 5899 adult subjects and 1304 influenza cases with interval-censored information on HI titre. The parameters of the relationship between HI titre and clinical protection were estimated using Bayesian inference with a consideration of random effects and censorship in the available information. Results A significant and positive relationship between HI titre and clinical protection against influenza was observed in all tested models. This relationship was found to be similar irrespective of the type of viral strain (A or B and the vaccination status of the individuals. Conclusion Although limitations in the data used should not be overlooked, the relationship derived in this analysis provides a means to predict the efficacy of inactivated influenza vaccines when only immunogenicity data are available. This relationship can also be useful for comparing the efficacy of different influenza vaccines based on their immunological profile.

  10. Expression of Yes-associated protein in non-small cell lung cancer and its relationship with clinical pathological factors

    Institute of Scientific and Technical Information of China (English)

    SU Li-li; MA Wei-xia; YUAN Jian-feng; SHAO Yang; XIAO Wei; JIANG Shu-juan

    2012-01-01

    Background Yes-associated protein(YAP)plays an important role in signal transduction and gene transcription regulation in normal cells,with elevated and over-expressed YAP levels observed in various malignant tumors.The aim of this study was to investigate the expression of YAP in non-small cell lung cancer(NSCLC),and to study the possible relationship of YAP expression with the occurrence and development of NSCLC.Methods YAP expression was assessed in 40 cases of NSCLC tumor tissues by immunohistochemistry,and their protein and mRNA levels were evaluated through Western blotting and reverse transcription-polymerase chain reaction(PCR),respectively.Normal lung tissues obtained from the same patient were used as control.Statistical analysis was performed to correlate the YAP expression to clinical pathological factors,such as tumor type,stage and grade.Results YAP-positive expression was found in 28(70%)of the 40 cases of NSCLC,which included 10 cases of squamous cell carcinoma(25%),17 cases of adenocarcinoma(42.5%)and 1 case of squamous adenocarcinoma(2.5%).In the 28 YAP-positive cases,19 cases showed lymph node metastasis and were classified in TNM stage Ⅱ+Ⅲ(47.5%);the other nine cases showed no lymph node metastasis(22.5%)and were classified in the TNM stage Ⅰ.There was no relationship between YAP expression and patients'age,gender or tumor histological grades.However,YAP showed significant over expression in late period of T stage(P=0.012),TNM stage(P=0.039),and lymph node metastasis(P=0.013),respectively.Notably,YAP-positive expression was significantly higher in adenocarcinoma than that in squamous cell carcinoma(P=0.041).Conclusions Over-expression of YAP was associated with NSCLC,especially lung adenocarcinoma.The high YAP expression in late period of tumor stage and lymph node metastasis may indicate that YAP expression could be an early marker for NSCLC tumorigenesis.

  11. Preliminary findings of cortical thickness abnormalities in blast injured service members and their relationship to clinical findings.

    Science.gov (United States)

    Tate, D F; York, G E; Reid, M W; Cooper, D B; Jones, L; Robin, D A; Kennedy, J E; Lewis, J

    2014-03-01

    Though cortical abnormalities have been demonstrated in moderate and severe traumatic brain injured (TBI) patients, there have been no studies examining cortical changes following blast related mild TBI (mTBI). The purpose of this study was to determine the effects and functional relevance of blast mTBI on cortical thickness in a small cohort of carefully screened blast injured US Service Members (SM). Twelve SM with mTBI acquired through blast injury were compared to 11 demographically matched control SM without TBI. Both mTBI and control participants were active duty and had completed a combat deployment. Subjects underwent MRI examination and the T1 weighted anatomic images were processed using the FreeSurfer suite of tools. Cortical thickness maps were compared between groups and examined for relationships with time since injury (TSI). Utilizing a large database of functional imaging results (BrainMap), significant regions of interest (ROI) were used to determine the behavioral profiles most consistently associated with the specific ROI. In addition, clinical variables were examined as part of post-hoc analysis of functional relevance. Group comparisons controlling for age demonstrated several significant clusters of cortical thinning for the blast injured SM. After multiple comparisons correction (False Discovery Rate (FDR)), two left hemisphere clusters remained significant (left superior temporal (STG) and frontal (SFG) gyri). No clusters were significantly correlated with TSI after FDR correction. Behavioral analysis for the STG and SFG clusters demonstrated three significant behavioral/cognitive sub-domains, each associated with audition and language. Blast injured SMs demonstrated distinct areas of cortical thinning in the STG and SFG. These areas have been previously shown to be associated with audition and language. Post-hoc analyses of clinical records demonstrated significant abnormal audiology reports for the blast injured SM suggesting that the

  12. Semicircular canal dehiscence: Frequency and distribution on temporal bone CT and its relationship with the clinical outcomes

    Energy Technology Data Exchange (ETDEWEB)

    Elmali, Muzaffer, E-mail: muzafel@yahoo.com.tr [Department of Radiology, Ondokuz Mayis University, Faculty of Medicine, Samsun (Turkey); Polat, Ahmet Veysel, E-mail: veyselp@hotmail.com [Department of Radiology, Ondokuz Mayis University, Faculty of Medicine, Samsun (Turkey); Kucuk, Harun, E-mail: hardrmd@yahoo.com [Department of Otorhinolaryngology, Ondokuz Mayis University, Faculty of Medicine, Samsun (Turkey); Atmaca, Sinan, E-mail: sinanatmaca@yahoo.com [Department of Otorhinolaryngology, Ondokuz Mayis University, Faculty of Medicine, Samsun (Turkey); Aksoy, Ahmet, E-mail: toxocara47@hotmail.com [Department of Otorhinolaryngology, Ondokuz Mayis University, Faculty of Medicine, Samsun (Turkey)

    2013-10-01

    Purpose: In this study, we aimed to investigate the frequency of SCD and its distribution and relationship with clinical outcomes on thin-section CT of the temporal bone. Materials and methods: Digital temporal bone CT images of 850 consecutive patients (1700 temporal bone CTs, 5100 SCs) who presented with a range of complaints such as vertigo, deafness, ear pain, fullness, and discharge between January 2008 and December 2011 were re-evaluated. Axial and oblique coronal reconstruction images of the temporal bone were made with a reconstruction thickness of 0.5 mm. Additionally, superior SC was evaluated in two perpendicular planes. Results: Out of 850 patients, 70 had completely normal temporal bone CT. Ninety-three patients had at least one SCD. In the temporal bone-based evaluation, 119 (26 bilateral, 67 unilateral) of 1700 temporal bones (7%) showed dehiscence. The SC-based evaluation revealed 125 SCD (2.5%) in 5100 SCs. The total number and rates of SCD were as follows: superior 103 (82.4%), posterior 13 (10.4%), and lateral nine (7.2%). Twenty of the 93 patients with SCD (21.5%) revealed no other findings on their temporal bone CTs. We determined a significant correlation between vestibular complaints, conductive hearing loss and SCD but there was no correlation between mixed, sensorineural hearing loss and SCD. Conclusion: We determined the frequency of SCD in 11% of patients and 7% of temporal bones. With regards to the distribution, the superior SC showed the highest dehiscence rate (82.4%). We found a significant correlation between vestibular symptoms, conductive hearing loss and SCD.

  13. Dimensional ultrasonographic relationship of the right lobe of pancreas with associated anatomic landmarks in clinically normal dogs.

    Science.gov (United States)

    Wickramasekara Rajapakshage, Bandula Kumara; Ellearaewe Garuhamilage, Janaka Pradeep Kumara; De Silva, Dona Daphney Niranjala; Dangolla, Ashoka

    2016-01-01

    The purpose of this prospective study was to establish the ultrasonographic characteristics of the dimension of the right pancreatic lobe with that of the associated anatomic landmarks in healthy dogs. Ultrasonographic examinations were performed on 25 dogs. The thickness of the right pancreatic lobe was compared with that of mural thickness of duodenum, diameter of duodenum, pancreatic duct, abdominal aorta, portal vein, caudal vena cava, and length and width of the right kidney and right adrenal gland. The correlation between each pancreatic parameter and the dimensions of the anatomical landmarks were assessed using linear regression analysis and Pearson's correlation coefficient (r) test. Significant, but weak linear correlations were observed between thickness of right pancreatic lobe with that of duodenum mural thickness (r=0.605, R(2)=0.339, P=0.001); duodenum diameter (r=0.573, R(2)=0.299, P=0.003); and right adrenal gland length (r=0.508, R(2)=0.052, P=0.01). There was no significant dimensional relationship with other selected anatomic landmarks. The ratio between the thickness of right pancreatic lobe and the mural thickness of duodenum, diameter of duodenum and length of right adrenal gland were 2.88 ± 0.53, 1.27 ± 0.27 and 0.81 ± 0.15, respectively. Calculating the ratio of thickness of the right pancreatic lobe with the dimension of significantly correlated anatomic landmarks is a useful and simple method for evaluating the size of the right pancreatic lobe in dogs in clinical practice. PMID:26234888

  14. The relationship between baseline Organizational Readiness to Change Assessment subscale scores and implementation of hepatitis prevention services in substance use disorders treatment clinics: a case study

    Directory of Open Access Journals (Sweden)

    Hagedorn Hildi J

    2010-06-01

    Full Text Available Abstract Background The Organizational Readiness to Change Assessment (ORCA is a measure of organizational readiness for implementing practice change in healthcare settings that is organized based on the core elements and sub-elements of the Promoting Action on Research Implementation in Health Services (PARIHS framework. General support for the reliability and factor structure of the ORCA has been reported. However, no published study has examined the utility of the ORCA in a clinical setting. The purpose of the current study was to examine the relationship between baseline ORCA scores and implementation of hepatitis prevention services in substance use disorders (SUD clinics. Methods Nine clinic teams from Veterans Health Administration SUD clinics across the United States participated in a six-month training program to promote evidence-based practices for hepatitis prevention. A representative from each team completed the ORCA evidence and context subscales at baseline. Results Eight of nine clinics reported implementation of at least one new hepatitis prevention practice after completing the six-month training program. Clinic teams were categorized by level of implementation-high (n = 4 versus low (n = 5-based on how many hepatitis prevention practices were integrated into their clinics after completing the training program. High implementation teams had significantly higher scores on the patient experience and leadership culture subscales of the ORCA compared to low implementation teams. While not reaching significance in this small sample, high implementation clinics also had higher scores on the research, clinical experience, staff culture, leadership behavior, and measurement subscales as compared to low implementation clinics. Conclusions The results of this study suggest that the ORCA was able to measure differences in organizational factors at baseline between clinics that reported high and low implementation of practice

  15. MITRAL ANNULAR CALCIFICATION IN ELDERLY PATIENTS: RELATIONSHIP WITH CLINICAL MANIFESTATIONS AND RISK FACTORS OF CARDIOVASCULAR DISEASES CAUSED BY ATHEROSCLEROSIS

    Directory of Open Access Journals (Sweden)

    G. M. Urvacheva

    2011-01-01

    Full Text Available The aim – to study the association of the mitral annular calcification (MAC with traditional risk factors and clinical manifestations of atherosclerosisin patients aged over 65 years without diabetes.Materials and methods. The prospective study included 100 patients over 65 years with MAC consistently identified among 910 ambulatory patients after transthoracic Doppler echocardiography in relation to the symptoms of cardiovascular disease. The comparison group consisted of 65 consecutively examined patients aged over 65 with no MAC.Results. When comparing risk factors in patients with and without MAC, MAC statistically significant differences was found with age (72,4 ± 5,4 and 70,2 ± 4,3 years, respectively; p = 0,006, the incidence of hypertension of moderate and severe degree (99 % and 90.8 % of patients, p = 0.012, levels of total cholesterol – TC (6,91 ± 0,92 and 6,2 ± 0,90 mmol / l, p = 0.0008 and lipoproteinlow density (3,57 ± 0,95 and 2,96 ± 0,96 mmol / l, p = 0.004 in subgroups of patients aged 65 to 70 years. In multivariate analysis remained statistically significant association of MAC only with age (p = 0,025, β = 0,173 and total cholesterol levels (p = 0,040; β = 0,160. Averages of the coefficient of atherogenicity of blood lipids, systolic and diastolic blood pressure, C-reactive protein, body mass index, waist circumference, the frequency of smoking, and risk assessment on a scale of SCORE in groups of patients with and without MAC did not differ significantly. In patients with MAC was higher incidence of myocardial infarction (p = 0.024 and more often than in patients without MAC, diagnosed coronary heart disease (p = 0.029. In the multivariate analysis adjusted for age and total cholesterol level is set significantly associated with the presence and extent of MAC with symptomatic atherosclerotic peripheral arterial disease (p < 0,00001; β = 0,410.Conclusion. In patients with MAC older than 65 years without diabetes

  16. The relationship between personality traits and psychotic like experiences in a large non-clinical adolescent sample

    NARCIS (Netherlands)

    Wiltink, S.; Nelson, B.; Velthorst, E.; Wigman, J. T. W.; Lin, A.; Baksheev, G.; Cosgrave, E.; Ross, M.; Ryan, J.; Yung, A. R.

    2015-01-01

    Objective: The relationship between personality and psychosis is well established. It has been suggested that this relationship may be partly accounted for by higher levels of depression in individuals with certain personality traits. We explored whether the link between personality and psychotic sy

  17. Mobile and Fixed Computer Use by Doctors and Nurses on Hospital Wards: Multi-method Study on the Relationships Between Clinician Role, Clinical Task, and Device Choice

    OpenAIRE

    Andersen, Pia; Lindgaard, Anne-Mette; Prgomet, Mirela; Creswick, Nerida; Westbrook, Johanna I.

    2009-01-01

    Background Selecting the right mix of stationary and mobile computing devices is a significant challenge for system planners and implementers. There is very limited research evidence upon which to base such decisions. Objective We aimed to investigate the relationships between clinician role, clinical task, and selection of a computer hardware device in hospital wards. Methods Twenty-seven nurses and eight doctors were observed for a total of 80 hours as they used a range of computing devices...

  18. Investigation of the Relationship Between Clinical and EEG Findings of Photosensitive Epilepsy and GABA Receptor Alpha 1 Subunit (GABRA1) Gene Mutations

    OpenAIRE

    Yavuz, E.N.; Demirkan, A.; Moen, S.; Ozdemir, O.; Catal, S.; Bebek, N.; Ozbek, U; Baykan, B.

    2011-01-01

    Objective: Although photosensitive epilepsy (PE) is commonly observed, its pathophysiology has not been clarified yet. However, relevant literature indicates that genetic factors play an important role. Our aim was to investigate whether there is a relationship between the clinical and electroencephalographic (EEG) features and the possible mutations/polymorphisms in the GABA receptor alpha 1 subunit (GABRA1) gene in patients with PE by scanning this gene. Methods: 54 patients diagnosed as ha...

  19. The relationship development assessment - research version: preliminary validation of a clinical tool and coding schemes to measure parent-child interaction in autism.

    Science.gov (United States)

    Larkin, Fionnuala; Guerin, Suzanne; Hobson, Jessica A; Gutstein, Steven E

    2015-04-01

    The aim of this project was to replicate and extend findings from two recent studies on parent-child relatedness in autism (Beurkens, Hobson, & Hobson, 2013; Hobson, Tarver, Beurkens, & Hobson, 2013, under review) by adapting an observational assessment and coding schemes of parent-child relatedness for the clinical context and examining their validity and reliability. The coding schemes focussed on three aspects of relatedness: joint attentional focus (Adamson, Bakeman, & Deckner, 2004), the capacity to co-regulate an interaction and the capacity to share emotional experiences. The participants were 40 children (20 with autism, 20 without autism) aged 6-14, and their parents. Parent-child dyads took part in the observational assessment and were coded on these schemes. Comparisons were made with standardised measures of autism severity (Autism Diagnostic Observation Schedule, ADOS: Lord, Rutter, DiLavore, & Risi, 2001; Social Responsiveness Scale, SRS: Constantino & Gruber, 2005), relationship quality (Parent Child Relationship Inventory, PCRI: Gerard, 1994) and quality of parent-child interaction (Dyadic Coding Scales, DCS: Humber & Moss, 2005). Inter-rater reliability was very good and, as predicted, codes both diverged from the measure of parent-child relationship and converged with a separate measure of parent-child interaction quality. A detailed profile review revealed nuanced areas of group and individual differences which may be specific to verbally-able school-age children. The results support the utility of the Relationship Development Assessment - Research Version for clinical practice. PMID:24366957

  20. 法国侦查主体有关问题初探——兼与中国侦查主体比较研究%Preliminary Analysis of the issues on Investigation Subject in France --Comparative Study on Investigation Subject in C

    Institute of Scientific and Technical Information of China (English)

    肖军

    2011-01-01

    France is a typical civil law country , the "typical" means strong sense of authority principle. The main investigation subjects, such as the judicial police, prosecutor and pre-trial judge are unique in France. Compared with our country's police, prosecu%法国是典型的大陆法系国家,“典型”意味着职权主义色彩浓厚。而法国的侦查主体,如司法警察、检察官、预审法官都是比较有特色的。通过与我们国家的警察、检察官等相比较,发现两国侦查主体都处在改革阶段,既有相同的发展趋势、规律,又有似是而非的差异之处。只有全面了解、熟悉并深入剖析,才能发现我国改革的症结所在,才能更好地完善侦查主体这一侦查学基础概念的内涵和外延。

  1. Relationship between Homesickness and Test Anxiety in Non-Native Students of Shiraz University of Medical Sciences International Branch in the Clinical and Physiopathology Course In 2013

    Science.gov (United States)

    Azizi, Saman

    2016-01-01

    Introduction: Anxiety is an emotional and physiological response to the internal felling of overall danger that is easily resolved. The aim of this study has been to determine the relationship between exam anxiety and the feeling of homesickness among non-native students. Methodology: The present study is cross-sectional and the subjects in this study are 80 non-native male and female PhD candidates in clinical and physiopathology majors in 2013 academic year that have been evaluated with the help of Persian homesickness questionnaire and Sarason’s test anxiety questionnaire and the data was analyzed using Pearson’s correlation coefficient. Results: With regard to the Pearson’s correlation coefficient there is a significant and reverse relationship between the desire to return to home and exam anxiety (r=0.0344, p=0.004) and there is a significant and reverse relationship between the Compatibility and exam anxiety (r=0.428, p<0.0001) and there is a significant and direct relationship between the feeling of alone and exam anxiety (r=0.888, p<0.0001). Discussion & Conclusion: There is a significant relationship between the feeling of homesickness and exam anxiety and the mental health of non-native students will be deteriorated by the feeling of homesickness and anxiety. PMID:26925920

  2. The relationship between clinical stage, prognosis and myocardial damage in patients with Duchenne-type muscular dystrophy. Five-year follow-up study

    International Nuclear Information System (INIS)

    The evaluation of myocardial damage by [123I]15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) imaging, which represents free fatty acid metabolism, has not been reported in patients with Duchenne-type muscular dystrophy (DMD). To date, the relationship between clinical stage, prognosis and myocardial damage has not been evaluated by radionuclear cardiac imaging. The main goal of this study was to elucidate the relationship of quantitative indices of myocardial damage obtained by radionuclear cardiac imaging ([201Tl] and [123I]BMIPP) to clinical stage and incidence of severe cardiac events in patients with Duchenne-type muscular dystrophy (DMD). The study population consisted of 28 male patients with DMD. The average age at the beginning of observation was 19.1±7.4 yrs. Nuclear tomographic imaging was performed using [201Tl] and [123I]BMIPP. The mid-ventricular short axial slices were classified into four anatomical regions, and the normalized count data in these areas (TL, BM) were obtained. The endpoint was the occurrence of heart failure during the follow up period. Thirteen cases of heart failure occurred during the 5-year follow-up period, including three cases with cardiac death due to congestive heart failure. Clinical staging correlated directly with TL (p=0.0118) and BM (p=0.0401) in the whole left ventricle. In regional TL analysis, an association was observed only in the septum (p=0.0151), and in the anterior (p=0.0361) region. The only discrepancy between the tracer parameters (TL-BM) in the septum was observed with the radionuclear cardiac values, which exhibited a relationship with cardiac events (p=0.0124). This discordance, TL201Tl] in this area was representative of the clinical stage, and TL-BM correlated well with the prognosis. (author)

  3. Is there a linear relationship between the Brief Psychiatric Rating Scale and the Clinical Global Impression-Schizophrenia scale? A retrospective analysis

    Directory of Open Access Journals (Sweden)

    Morishita Shigeru

    2010-12-01

    Full Text Available Abstract Background Although the Brief Psychiatric Rating Scale (BPRS is widely used for evaluating patients with schizophrenia, it has limited value in estimating the clinical weight of individual symptoms. The aim of this study was 4-fold: 1 to investigate the relationship of the BPRS to the Clinical Global Impression-Schizophrenia Scale (CGI-SCH, 2 to express this relationship in mathematical form, 3 to seek significant symptoms, and 4 to consider a possible modified BPRS subscale. Methods We evaluated 150 schizophrenia patients using the BPRS and the CGI-SCH, then examined the scatter plot distribution of the two scales and expressed it in a mathematical equation. Next, backward stepwise regression was performed to select BPRS items that were highly associated with the CGI-SCH. Multivariate regression was conducted to allocate marks to individual items, proportional to their respective magnitude. We assessed the influence of modifications to the BPRS in terms of Pearson's r correlation coefficient and r-squared to evaluate the relationship between the two scales. Utilizing symptom weighting, we assumed a possible BPRS subscale. Results By plotting the scores for the two scales, a logarithmic curve was obtained. By performing a logarithmic transformation of the BPRS total score, the curve was modified to a linear distribution, described by [CGI-SCH] = 7.1497 × log10[18-item BPRS] - 6.7705 (p Conclusions Limited within our data, a logarithmic relationship was assumed between the two scales, and not only individual items of the BPRS but also their weightings were considered important for a linear relationship and improvement of the BPRS for evaluating schizophrenia.

  4. A clinical investigation of the relationship between the quality of conventional complete dentures and the patients’ quality of life

    OpenAIRE

    Sara A. Alfadda; Hayam A. Al-Fallaj; Al-Banyan, Hajar A.; Ruba M. Al-Kadhi

    2015-01-01

    Objective: The purpose of this study was to determine whether there is a correlation between the clinical quality of conventional complete dentures and patient quality of life. Materials and methods: This study included a random sample of 32 completely edentulous patients (15 males and 17 females) who were treated with conventional complete dentures. Using a validated questionnaire, three investigators evaluated the dentures independently on the basis of seven clinical parameters: esthetic...

  5. European Academy of Allergy and Clinical Immunology task force report on 'dose-response relationship in allergen-specific immunotherapy'

    DEFF Research Database (Denmark)

    Calderón, M A; Larenas, D; Kleine-Tebbe, J;

    2011-01-01

    For a century, allergen-specific immunotherapy (SIT) has proven to be an effective treatment for allergic rhinitis, asthma, and insect sting allergy. However, as allergen doses are frequently adapted to the individual patient, there are few data on dose-response relationship in SIT. Allergen prod...

  6. Stress-Reactive Rumination, Negative Cognitive Style, and Stressors in Relationship to Depressive Symptoms in Non-Clinical Youth

    Science.gov (United States)

    Rood, Lea; Roelofs, Jeffrey; Bogels, Susan M.; Meesters, Cor

    2012-01-01

    The role of cognitive vulnerability in the development of depressive symptoms in youth might depend on age and gender. The current study examined cognitive vulnerability models in relationship to depressive symptoms from a developmental perspective. For that purpose, 805 youth (aged 10-18, 59.9% female) completed self-report measures.…

  7. The Role of Loneliness in the Relationship between Anxiety and Depression in Clinical and School-Based Youth

    Science.gov (United States)

    Ebesutani, Chad; Fierstein, Matthew; Viana, Andres G.; Trent, Lindsay; Young, John; Sprung, Manuel

    2015-01-01

    Identifying mechanisms that explain the relationship between anxiety and depression are needed. The Tripartite Model is one model that has been proposed to help explain the association between these two problems, positing a shared component called negative affect. The objective of the present study was to examine the role of loneliness in relation…

  8. The Increased Construct Validity and Clinical Utility of Assessing Relationship Quality Using Separate Positive and Negative Dimensions

    Science.gov (United States)

    Mattson, Richard E.; Paldino, Dawnelle; Johnson, Matthew D.

    2007-01-01

    The Positive and Negative Quality in Marriage Scale (F. D. Fincham & K. J. Linfield, 1997) is a self-report measure that separately assesses positive and negative dimensions of relationship quality. Fincham and Linfield found that ratings of positive and negative marital quality accounted for unique variance in maladaptive attributions and…

  9. Stress-reactive rumination, negative cognitive style, and stressors in relationship to depressive symptoms in non-clinical youth

    NARCIS (Netherlands)

    L. Rood; J. Roelofs; S.M. Bögels; C. Meesters

    2012-01-01

    The role of cognitive vulnerability in the development of depressive symptoms in youth might depend on age and gender. The current study examined cognitive vulnerability models in relationship to depressive symptoms from a developmental perspective. For that purpose, 805 youth (aged 10-18, 59.9% fem

  10. The relationship between knowledge of hiv, self-perceived vulnerability and sexual risk behavior among community clinic workers in chile

    OpenAIRE

    Cabieses, Baltica; Ferrer, Lilian; Villarroel, Luis; Tunstall, Helena; Norr, Kathleen

    2012-01-01

    Objective Testing the hypothesis of an association between knowledge and sexual risk behaviour (SRB) amongst community-clinic workers in Chile, explained by the confounding effect of self-perceived vulnerability to HIV. Methods A cross-sectional survey was analyzed; it was nested within a quasiexperimental study of 720 community-clinic workers in Santiago. The SRB score combined the number of sexual partners and condom use (coded as “high”/”low” SRB). Knowledge of HIV (a 25-item index) was co...

  11. Relationship between knowledge of hiv, self-perceived vulnerability and sexual risk behaviours among community clinic workers in chile

    OpenAIRE

    Cabieses Valdes, Baltica; Ferrer Lagunas, Lilian; Villarroel del Pino, Luis; Tunstall, Helena; Norr, Kathleen

    2014-01-01

    Objective: To test the hypothesis of an association between knowledge and sexual risk behaviours (SRB) among community-clinic workers in Chile, explained by the confounding effect of self-perceived vulnerability to HIV. Methods: Analysis of a cross-sectional survey, nested within a quasi-experimental study of 720 community-clinic workers in Santiago. The SRB score combined number of sexual partners and condom use, coded as “high”/“low” SRB. The Knowledge of HIV, a 25-item index, was coded as ...

  12. Understanding the relationship transitions and associated end of life clinical needs of young adults with life-limiting illnesses: A triangulated longitudinal qualitative study

    Science.gov (United States)

    Johnston, Bridget; Jindal-Snape, Divya; Pringle, Jan; Gold, Libby; Grant, Jayne; Dempsey, Raymond; Scott, Ros; Carragher, Pat

    2016-01-01

    Background: Care of young adults with life-limiting illnesses can often be complex due to the fact that they are growing and developing within the continuing presence of their illness. There is little research conducted nationally and internationally, which has examined the life issues of young adults or taken a longitudinal approach to understand such issues over a period of time. Aim: To gain clear understanding of one particular and pertinent life issue—relationship transition—occurring in the context of being a young adult with a life-limiting illness and the clinical needs arising from this. Design: This was a triangulated, longitudinal, qualitative study involving young adults with life-limiting illnesses and their significant others, namely, family members and healthcare professionals. Semi-structured interviews were conducted with participants and analysed using thematic analysis. Clinical case note reviews were also carried out. Setting/participants: A total of 12 young adults (aged between 17 and 23 years) from 2 hospices and 22 nominated significant others participated in a total of 58 interviews. Results: Thematic analysis revealed 4 main themes and 11 subthemes. The main themes were ‘Dependence dichotomy’, ‘In it together’, ‘Biographical uncertainty’, and ‘Conserving integrity’. These themes helped to establish the nature of relationship transitions that the young adult participants from the study experienced and additionally allowed insight into their possible needs at their end of life. Conclusion: This study has identified the nature of relationship transitions pertinent to young adults and has highlighted associated end of life clinical needs. This study can influence further research into the transitions and end of life needs of this particular patient group receiving palliative care, while informing the lacking evidence base which exists internationally. PMID:27781097

  13. Relationships between high-stakes clinical skills exam scores and program director global competency ratings of first-year pediatric residents

    Directory of Open Access Journals (Sweden)

    Erik E. Langenau

    2011-09-01

    Full Text Available Responding to mandates from the Accreditation Council for Graduate Medical Education (ACGME and American Osteopathic Association (AOA, residency programs have developed competency-based assessment tools. One such tool is the American College of Osteopathic Pediatricians (ACOP program directors’ annual report. High-stakes clinical skills licensing examinations, such as the Comprehensive Osteopathic Medical Licensing Examination Level 2-Performance Evaluation (COMLEX-USA Level 2-PE, also assess competency in several clinical domains.The purpose of this study is to investigate the relationships between program director competency ratings of first-year osteopathic residents in pediatrics and COMLEX-USA Level 2-PE scores from 2005 to 2009.The sample included all 94 pediatric first-year residents who took COMLEX-USA Level 2-PE and whose training was reviewed by the ACOP for approval of training between 2005 and 2009. Program director competency ratings and COMLEX-USA Level 2-PE scores (domain and component were merged and analyzed for relationships.Biomedical/biomechanical domain scores were positively correlated with overall program director competency ratings. Humanistic domain scores were not significantly correlated with overall program director competency ratings, but did show moderate correlation with ratings for interpersonal and communication skills. The six ACGME or seven AOA competencies assessed empirically by the ACOP program directors’ annual report could not be recovered by principal component analysis; instead, three factors were identified, accounting for 86% of the variance between competency ratings.A few significant correlations were noted between COMLEX-USA Level 2-PE scores and program director competency ratings. Exploring relationships between different clinical skills assessments is inherently difficult because of the heterogeneity of tools used and overlap of constructs within the AOA and ACGME core competencies.

  14. Relationships between organohalogen contaminants and blood plasma clinical-chemical parameters in chicks of three raptor species from Northern Norway

    DEFF Research Database (Denmark)

    Sonne, Christian; Bustnes, Jan Ove; Herzke, Dorte;

    2010-01-01

    Organohalogen contaminants (OHCs) may affect various physiological parameters in birds including blood chemistry. We therefore examined blood plasma clinical-chemical parameters and OHCs in golden eagle, white-tailed eagle and goshawk chicks from Northern Norway. Correlation analyses on pooled data......:creatinine were significantly positively correlated to various OHCs (all: pbone...

  15. Relationship between perception of facial emotions and anxiety in clinical depression : Does anxiety-related perception predict persistence of depression?

    NARCIS (Netherlands)

    Bouhuys, AL; Geerts, E; Mersch, PPA

    1997-01-01

    Within the framework of interpersonal theories on depression, it was postulated 1) that an anxiety-related mood-congruent bias with respect to the perception of facial expressions could be demonstrated in clinically depressed patients; 2) that the perception of negative facial emotions would be asso

  16. Tongue diagnosis:relationship between sublingual tongue morphology in three tongue protrusion angles and menstrual clinical symptoms

    Institute of Scientific and Technical Information of China (English)

    Tim Hideaki Tanaka

    2015-01-01

    OBJECTIVE:The morphological and color characteristics of the tongue sublingual veins (SLVs) can manifest differently within the subjects, depending on the way their tongue is curled upward. This study was conducted in order to investigate the clinical relevancy of tongue SLV diagnosis in relation to menstrual clinical symptoms (pain, clots, heavy, and scanty), using three different inspection procedures (IP1, IP2, and IP3). METHODS: Three-hundred and seventy-seven female patients were asked to stick out their tongues in three speciifc ways which were intended to create different tongue protrusion angles. The SLV parameters for thickness (TK), length (LE), color (CL), shape (SP), and nodules (ND) were then evaluated. RESULTS: According to the results of the Waldχ2 test, IP1 provides the best model for pain (R2 = 0.155), IP3 for clots (R2 = 0.437), IP2 for heavy (R2 = 0.268), and scanty (R2 = 0.192). Abnormal SLV diagnostic parameters were most strongly associated with the clinical symptom of clots (R2= 0.492). CONCLUSION: While the study showed the relations between tongue SLV features and menstrual clinical symptoms, as wel it showed that IP2 was the best overal predictor for the symptomatic indexes used in this study, and using one particular SLV inspection procedure may not be sufifcient. The application of a particular inspection method alone may cause under- or over-estimation of SLV abnormalities.

  17. Ensure the Safety of Clinical Medicine, Harmonious Doctor-patient Relationship%保证临床用药安全,和谐医患关系

    Institute of Scientific and Technical Information of China (English)

    郑雪梅

    2014-01-01

    通过临床中存在的用药不安全之事例,指出医生,药师,护士在工作中应如何预防错误用药,尽量预防差错事故的发生,确保临床用药安全,提高医疗服务质量,为构建和谐医患关系而努力。%The existing in clinical medication unsafe case, said doctors, pharmacists, nurses should be how to prevent medication er ors at work, try to prevent accidents, ensure the safety of clinical use, improve the quality of medical service, and strive to build a harmonious relationship between doctors and patients.

  18. Relationship between expression of α-fetoprotein messenger RNA and some clinical parameters of human hepatocellular carcinoma

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    AIM To certify the relationship between AFP mRNA and some pathological parameters of he-patocellular carcinoma (HCC).METHOD We detected the expression of AFP in mRNA level in tissue samples from 52 patients suffering from HCC by RT-PCR method.RESULTS The positive rate of AFP mRNA was 76.9% in the HCC tumor tissues, and 69.4% in the paratumor tissues from the HCC patients with severe cirrhosis. However, in HCC patients without cirrhosis, the positive rate reached 50% in tumor tissues, but no AFP mRNA expression was found in the related paratumor tissues.CONCLUSION The AFP protein was specially expressed by HCC cells and mutated hepatocytes. The AFP mRNA was positively related with cirrhosis, but no significant relationship was found between AFP mRNA and tumor size, capsule status and tumor metastasis.

  19. RELATIONSHIP OF GENE’S POLYMORPHISM OF TOLL-LIKE RECEPTOR 4 WITH CLINICAL AND IMMUNOLOGICAL PARAMETERS IN ATOPIC ASTHMA

    OpenAIRE

    Lyakhovskaya, N.

    2013-01-01

    Bronchial asthma is an example of multifactorial disease that occurs in the interaction of environmental factors and genetic predisposition. The aim of the study was to evaluate the significance of polymorphism Asp299Gly change A to G at position 896 (rs4986790) TLR4 gene and its relationship with the immunoregulatory factors in the mechanisms of atopic asthma (AA). Materials and Methods: We examined 45 people AA patients. The diagnosis of the AA and its severity is set in accordance with the...

  20. The relationship between clinical indicators, coping styles, perceived support and diabetes-related distress among adults with type 2 diabetes

    OpenAIRE

    Karlsen, Bjørg; Oftedal, Bjørg; Bru, Edvin

    2012-01-01

    Aim: This article is a report of a cross-sectional study examining the degree to which clinical indicators, coping styles and perceived support from healthcare professionals and family are related to diabetes-related distress. Background: Many people with type 2 diabetes experience high levels of distress stemming from concerns and worries associated with their disease. Diabetes-related distress has predominantly been studied in relation to diabetes management and metabolic contro...

  1. Relationship between the chest radiograph, regional lung function studies, exercise tolerance, and clinical condition in cystic fibrosis.

    OpenAIRE

    Coates, A L; Boyce, P; Shaw, D. G.; Godfrey, S; Mearns, M

    1981-01-01

    This study evaluated the accuracy of the interpretation of the chest film in delineating localised abnormalities of ventilation and perfusion, as well as the overall severity of airways obstruction, exercise tolerance, and clinical condition in children with cystic fibrosis. Radiographic findings in various regions of the chest film were compared with the functional values obtained with regional lung function tests which evaluated the arrival and disappearance of boluses of radioactive nitrog...

  2. Relationship between serologic response and clinical symptoms in children with enterovirus 71-infected hand-foot-mouth disease

    OpenAIRE

    Shen, Jun; Zhao,Chao; Cao, Ping; Shi, Peng; Cao, Lingfeng; Zhu, Qirong

    2015-01-01

    This study aimed to explore the correlation between clinical symptoms, including rash and fever, and serum antibody reaction to enterovirus 71 (EV71) infection in children hospitalized due to hand-foot-mouth disease (HFMD). From May 2014 to July 2014, a total of 547 children hospitalized due to HFMD in Children’s Hospital of Fudan University were enrolled retrospectively. RNA levels of EV71 and CA16 in fecal, serum, and cerebrospinal fluid specimens were measured using quantitative real-time ...

  3. Progressive outer retinal necrosis syndrome: a comprehensive review of its clinical presentation, relationship to immune system status, and management.

    Science.gov (United States)

    Austin

    2000-12-01

    Progressive outer retinal necrosis (PORN) syndrome is a form of the Varicella zoster virus (VZV) chorioretinitis found almost exclusively in people with the acquired immunodeficiency syndrome (AIDS). This destructive infection has an extremely rapid course that may lead to no light perception in affected eyes within days or weeks. Attempts at its treatment have had limited success. Rhegmatogenous retinal detachments often occur after the development of atrophic retinal holes, and silicone oil temponade has been found to be the most successful reattachment procedure. Unfortunately, cataract formation is common after such surgery. PORN needs to be differentiated from acute retinal necrosis (ARN) syndrome, a necrotizing retinitis that can also be caused by VZV. PORN and ARN are found at opposite ends of the spectrum of necrotizing herpetic retinopathies (NHR), where its clinical presentation depends upon immune system status. After a brief case presentation, the distinguishing clinical characteristics of PORN, its differentiation from ARN, attempts at its treatment, the role of the immune system status on its clinical appearance and treatment, and management of complications such as retinal detachment and subsequent cataracts are discussed.

  4. The relationship of hardiness and social support to student appraisal of stress in an initial clinical nursing situation.

    Science.gov (United States)

    Pagana, K D

    1990-06-01

    The stressful nature of the clinical experience of nursing students was examined within the context of Lazarus' theory of cognitive appraisal of stress. The students' evaluation of their initial medical-surgical clinical experience as a threat or a challenge was determined along with the hypothesized mediating variables of hardiness and social support. The sample of 246 students from seven different colleges and universities in Pennsylvania completed a hardiness measure, the Norbeck Social Support Questionnaire (NSSQ), and a Clinical Stress Questionnaire (CSQ). Although the correlations were low, hardiness was found to be positively related to the evaluation of challenge and negatively related to the evaluation of threat. Social support was positively related to the evaluation of challenge only when using a work-related measure of support. The hypothesis that social support would be negatively related to the evaluation of threat was not supported. This research raises important questions related to the theories of hardiness, social support, and cognitive appraisal of stress. Implications for further research in this area are offered.

  5. Evaluation of the Cerebral State Index in Cats under Isoflurane Anaesthesia: Dose-Effect Relationship and Prediction of Clinical Signs

    Directory of Open Access Journals (Sweden)

    Joana R. Sousa

    2014-01-01

    Full Text Available The performance of the cerebral state index (CSI in reflecting different levels of isoflurane anaesthesia was evaluated in ten cats subjected to four end-tidal isoflurane concentrations (EtIso, each maintained for 15 minutes (0.8%, 1.2%, 1.6%, or 2.0% EtIso. The CSI, hemodynamic data, ocular reflexes, and eye position were recorded for each EtIso concentration. Pharmacodynamic analysis of CSI with EtIso was performed, as well as prediction probability analysis with a clinical scale based on the eye reflexes. The CSI values showed great variability. Between all parameters, burst suppression ratio showed the better fitting with the sigmoidal concentration-effect model (R2=0.93 followed by CSI (R2=0.82 and electromyographic activity (R2=0.79. EtIso was the variable with better prediction of the clinical scale of anaesthesia (prediction probability value of 0.94. Although the CSI values decrease with increasing isoflurane concentrations, the huge variability in CSI values may be a strong limitation for its use in cats and it seems to be no better than EtIso as a predictor of clinical signs.

  6. The study of relationship between reported temporomandibular symptoms and clinical dysfunction index among university students in Shiraz

    Directory of Open Access Journals (Sweden)

    Mahroo Vojdani

    2012-01-01

    With respect to gender, women (80% were more affected than men (62%. A significant relationship was found between gender and the occurrence of temporomandibular disorder (TMD (P<0.05. The correlation coefficient (r between the reported symptoms (Ai and recorded signs (Di was 0.53. There were positive correlation coefficient between Di and Ai. They were statistically significant (P<0.001. Conclusions: A high prevalence of signs and symptoms of TMD among students in Shiraz University of Medical Sciences was seen, which was greater in women. Despite suffering from TMD, students were not aware of their disorders.

  7. Clinical implications of the Women's Ischemia Syndrome Evaluation: inter-relationships between symptoms, psychosocial factors and cardiovascular outcomes.

    Science.gov (United States)

    Handberg, Eileen M; Eastwood, Jo-Ann; Eteiba, Wafia; Johnson, B Delia; Krantz, David S; Thompson, Diane V; Vaccarino, Viola; Bittner, Vera; Sopko, George; Pepine, Carl J; Merz, Noel Bairey; Rutledge, Thomas R

    2013-09-01

    Cardiovascular disease remains the leading cause of death in the USA and is associated with several modifiable (hypertension, diabetes, high cholesterol, tobacco use, physical inactivity, obesity and unhealthy diet) and nonmodifiable (age, gender and family history) risk factors. The role of psychosocial risk factors in the development of cardiovascular disease has a growing body of literature, and differences in men and women have been identified. The Women's Ischemia Syndrome Evaluation provides insight into psychosocial risk factors in a cohort of women presenting with chest pain who had a comprehensive battery of psychosocial assessments and long-term follow-up. This review focuses on symptom presentation for chest pain and its relationship to cardiovascular disease morbidity and mortality, quality of life, healthcare costs and psychosocial predictor variables, including anxiety, depression, hostility and social networks. In the Women's Ischemia Syndrome Evaluation, persistent chest pain was associated with an increased rate of adverse events and relatively high rates of depression and anxiety, with reduced functional capacity and impaired quality of life, over a median of 6 years of follow-up. More research is needed to better understand the relationships between symptoms and negative emotions and to determine whether psychological (pharmacologic and/or cognitive) interventions might impact both psychological and cardiovascular outcomes.

  8. On better estimating and normalizing the relationship between clinical parameters: comparing respiratory modulations in the photoplethysmogram and blood pressure signal (DPOP versus PPV).

    Science.gov (United States)

    Addison, Paul S; Wang, Rui; Uribe, Alberto A; Bergese, Sergio D

    2015-01-01

    DPOP (ΔPOP or Delta-POP) is a noninvasive parameter which measures the strength of respiratory modulations present in the pulse oximeter waveform. It has been proposed as a noninvasive alternative to pulse pressure variation (PPV) used in the prediction of the response to volume expansion in hypovolemic patients. We considered a number of simple techniques for better determining the underlying relationship between the two parameters. It was shown numerically that baseline-induced signal errors were asymmetric in nature, which corresponded to observation, and we proposed a method which combines a least-median-of-squares estimator with the requirement that the relationship passes through the origin (the LMSO method). We further developed a method of normalization of the parameters through rescaling DPOP using the inverse gradient of the linear fitted relationship. We propose that this normalization method (LMSO-N) is applicable to the matching of a wide range of clinical parameters. It is also generally applicable to the self-normalizing of parameters whose behaviour may change slightly due to algorithmic improvements. PMID:25691912

  9. On Better Estimating and Normalizing the Relationship between Clinical Parameters: Comparing Respiratory Modulations in the Photoplethysmogram and Blood Pressure Signal (DPOP versus PPV

    Directory of Open Access Journals (Sweden)

    Paul S. Addison

    2015-01-01

    Full Text Available DPOP (ΔPOP or Delta-POP is a noninvasive parameter which measures the strength of respiratory modulations present in the pulse oximeter waveform. It has been proposed as a noninvasive alternative to pulse pressure variation (PPV used in the prediction of the response to volume expansion in hypovolemic patients. We considered a number of simple techniques for better determining the underlying relationship between the two parameters. It was shown numerically that baseline-induced signal errors were asymmetric in nature, which corresponded to observation, and we proposed a method which combines a least-median-of-squares estimator with the requirement that the relationship passes through the origin (the LMSO method. We further developed a method of normalization of the parameters through rescaling DPOP using the inverse gradient of the linear fitted relationship. We propose that this normalization method (LMSO-N is applicable to the matching of a wide range of clinical parameters. It is also generally applicable to the self-normalizing of parameters whose behaviour may change slightly due to algorithmic improvements.

  10. Bacterial communities in women with bacterial vaginosis: high resolution phylogenetic analyses reveal relationships of microbiota to clinical criteria.

    Directory of Open Access Journals (Sweden)

    Sujatha Srinivasan

    Full Text Available BACKGROUND: Bacterial vaginosis (BV is a common condition that is associated with numerous adverse health outcomes and is characterized by poorly understood changes in the vaginal microbiota. We sought to describe the composition and diversity of the vaginal bacterial biota in women with BV using deep sequencing of the 16S rRNA gene coupled with species-level taxonomic identification. We investigated the associations between the presence of individual bacterial species and clinical diagnostic characteristics of BV. METHODOLOGY/PRINCIPAL FINDINGS: Broad-range 16S rRNA gene PCR and pyrosequencing were performed on vaginal swabs from 220 women with and without BV. BV was assessed by Amsel's clinical criteria and confirmed by Gram stain. Taxonomic classification was performed using phylogenetic placement tools that assigned 99% of query sequence reads to the species level. Women with BV had heterogeneous vaginal bacterial communities that were usually not dominated by a single taxon. In the absence of BV, vaginal bacterial communities were dominated by either Lactobacillus crispatus or Lactobacillus iners. Leptotrichia amnionii and Eggerthella sp. were the only two BV-associated bacteria (BVABs significantly associated with each of the four Amsel's criteria. Co-occurrence analysis revealed the presence of several sub-groups of BVABs suggesting metabolic co-dependencies. Greater abundance of several BVABs was observed in Black women without BV. CONCLUSIONS/SIGNIFICANCE: The human vaginal bacterial biota is heterogeneous and marked by greater species richness and diversity in women with BV; no species is universally present. Different bacterial species have different associations with the four clinical criteria, which may account for discrepancies often observed between Amsel and Nugent (Gram stain diagnostic criteria. Several BVABs exhibited race-dependent prevalence when analyzed in separate groups by BV status which may contribute to increased

  11. Relationship between acne vulgaris and attention-deficit/hyperactivity disorder symptoms in a clinical sample of women*

    Science.gov (United States)

    Bilgic, Ayhan; Bilgic, Özlem; Çolak, Rukiye Sivri; Altınyazar, Hilmi Cevdet

    2016-01-01

    Acne vulgaris has recently been reported to be associated with elevated rates of attention deficit/hyperactivity disorder in epidemiological studies. This report examines childhood and current attention-deficit/hyperactivity disorder symptoms in a clinical sample of female adults. Ninety-one women with acne vulgaris and 53 controls were included in this study. The aforementioned symptoms were measured in participants. No significant differences were found between patients and controls in any of the measurements. Contrary to the findings of epidemiological studies, this study did not uncover a link between acne vulgaris and attention-deficit/hyperactivity disorder PMID:27192533

  12. Selection of glutamate-rich protein long synthetic peptides for vaccine development: antigenicity and relationship with clinical protection and immunogenicity

    DEFF Research Database (Denmark)

    Theisen, M; Dodoo, D; Toure-Balde, A;

    2001-01-01

    Antibodies against three long synthetic peptides (LSPs) derived from the glutamate-rich protein (GLURP) of Plasmodium falciparum were analyzed in three cohorts from Liberia, Ghana, and Senegal. Two overlapping LSPs, LR67 and LR68, are derived from the relatively conserved N-terminal nonrepeat...... from clinical P. falciparum malaria. Protected children from the Ghana cohort possessed predominantly IgG1 antibodies against the nonrepeat epitope and IgG3 antibodies against the repeat epitope. T-cell proliferation responses, studied in the cohort from Senegal, revealed that T-helper-cell epitopes...

  13. Relationship between the clinical characteristics of osteomyelitis and the finding of extraosseous fat on MRI in pediatric patients

    International Nuclear Information System (INIS)

    MRI is frequently utilized to evaluate patients for osteomyelitis. The findings of intramedullary and extramedullary fat globules as well as extramedullary fat-fluid levels can help improve the specificity of MRI for this diagnosis. To correlate these MRI findings with the clinical characteristics in children with osteomyelitis. A retrospective electronic medical record search for pediatric patient charts from March 2004 to November 2009 that contained the word ''osteomyelitis'' in the ''principal diagnosis'' portion of the international classification of disease (ICD) billing code. Each electronic chart was reviewed. MRI examinations of selected children were reviewed by a pediatric radiologist, a general radiologist and a transitional year resident. A total of 10 patients/11 MRI studies were included. Five of the 11 had the MRI finding of extramedullary globular fat signal. There was a significantly increased likelihood of seeing this finding in children of pubertal or postpubertal age compared to those of prepubertal age (p < 0.05). This study provides evidence that the MRI finding of extramedullary fat globules in children with acute osteomyelitis is associated with the clinical characteristic of being within or above the age range for puberty. (orig.)

  14. Cigarette smoking in male patients with chronic schizophrenia in a Chinese population: prevalence and relationship to clinical phenotypes.

    Directory of Open Access Journals (Sweden)

    Xiang Yang Zhang

    Full Text Available The high prevalence of smoking in schizophrenia of European background may be related to smoking's reducing clinical symptoms and medication side effects. Because smoking prevalence and its associations with clinical phenotypes are less well characterized in Chinese than European patients with schizophrenia, we assessed these smoking behaviors using clinician-administered questionnaires and the Fagerstrom Test for Nicotine Dependence (FTND in 776 Chinese male schizophrenia and 560 control subjects. Patients also were rated on the Positive and Negative Symptom Scale (PANSS, the Simpson and Angus Extrapyramidal Symptom Rating Scale (SAES, and the Abnormal Involuntary Movement Scale (AIMS. We found that the schizophrenia patients had a higher lifetime incidence of smoking (79% vs 63%, were more likely to be heavy smokers (61% vs 31%, and had lower smoking cessation rates (4% vs 9% (all p0.05 than the non-smoking patients. These results suggest that Chinese males with schizophrenia smoke more frequently than the general population. Further, smokers with schizophrenia may display fewer negative symptoms and possibly less parkinsonism than non-smokers with schizophrenia.

  15. Relationship between the clinical characteristics of osteomyelitis and the finding of extraosseous fat on MRI in pediatric patients

    Energy Technology Data Exchange (ETDEWEB)

    Mattis, Tod A. [Spectrum Health Helen Devos Children' s Hospital, Grand Rapids, MI (United States); Michigan State University, College of Human Medicine, Radiology, Grand Rapids, MI (United States); Grand Rapids Medical Education Partners, Grand Rapids, MI (United States); Borders, Heather L.; Ellinger, Doug M.; Junewick, Joseph J. [Spectrum Health Helen Devos Children' s Hospital, Grand Rapids, MI (United States); Michigan State University, College of Human Medicine, Radiology, Grand Rapids, MI (United States); Advanced Radiology Services, Grand Rapids, MI (United States)

    2011-10-15

    MRI is frequently utilized to evaluate patients for osteomyelitis. The findings of intramedullary and extramedullary fat globules as well as extramedullary fat-fluid levels can help improve the specificity of MRI for this diagnosis. To correlate these MRI findings with the clinical characteristics in children with osteomyelitis. A retrospective electronic medical record search for pediatric patient charts from March 2004 to November 2009 that contained the word ''osteomyelitis'' in the ''principal diagnosis'' portion of the international classification of disease (ICD) billing code. Each electronic chart was reviewed. MRI examinations of selected children were reviewed by a pediatric radiologist, a general radiologist and a transitional year resident. A total of 10 patients/11 MRI studies were included. Five of the 11 had the MRI finding of extramedullary globular fat signal. There was a significantly increased likelihood of seeing this finding in children of pubertal or postpubertal age compared to those of prepubertal age (p < 0.05). This study provides evidence that the MRI finding of extramedullary fat globules in children with acute osteomyelitis is associated with the clinical characteristic of being within or above the age range for puberty. (orig.)

  16. Relationship between clinical site of isolation and ability to form biofilms in vitro in nontypeable Haemophilus influenzae.

    Science.gov (United States)

    Obaid, Najla A; Jacobson, Glenn A; Tristram, Stephen

    2015-03-01

    Nontypeable Haemophilus influenzae (NTHi) is an opportunistic pathogen associated with a range of infections, including various lower respiratory infections, otitis media, and conjunctivitis. There is some debate as to whether or not NTHi produces biofilms and, if so, whether or not this is relevant to pathogenesis. Although many studies have examined the association between in vitro biofilm formation and isolates from a specific infection type, few have made comparisons from isolates from a broad range of isolates grouped by clinical source. In our study 50 NTHi from different clinical sources, otitis media, conjunctivitis, lower respiratory tract infections in both cystic fibrosis and non-cystic fibrosis patients, and nasopharyngeal carriage, plus 10 nasopharyngeal isolates of the commensal Haemophilus haemolyticus were tested for the ability to form biofilm by using a static microtitre plate crystal violet assay. A high degree of variation in biofilm forming ability was observed across all isolates, with no statistically significant differences observed between the groups, with the exception of the isolates from conjunctivitis. These isolates had uniformly lower biofilm forming ability compared with isolates from the other groups (p < 0.005). PMID:25706230

  17. Systematic review and meta-analysis: the relationship between the Helicobacter pylori dupA gene and clinical outcomes

    Directory of Open Access Journals (Sweden)

    Shiota Seiji

    2010-10-01

    Full Text Available Abstract Background In 2005, the first disease-specific Helicobacter pylori virulence factor that induced duodenal ulcer and had a suppressive action on gastric cancer has been identified, and was named duodenal ulcer promoting gene (dupA. However, the importance of the dupA gene on clinical outcomes is conflicting in subsequent studies. The aim of this study was to estimate the magnitude of the risk for clinical outcomes associated with dupA gene. Methods A meta-analysis of case-control studies which provided raw data on the infection rates with the dupA-positive H. pylori detected by polymerase chain reaction was performed. Results Seventeen studies with a total of 2,466 patients were identified in the search. Infection with the dupA-positive H. pylori increased the risk for duodenal ulcer by 1.41-fold (95% confidence interval [CI], 1.12-1.76 overall. Subgroup analysis showed that the summary odds ratio (OR was 1.57 (95% CI, 1.19-2.06 in Asian countries and 1.09 (95% CI, 0.73-1.62 in Western countries. There was no association between the presence of the dupA gene and gastric cancer and gastric ulcer. Publication bias did not exist. Conclusion Our meta-analysis confirmed the importance of the presence of the dupA gene for duodenal ulcer, especially in Asian countries.

  18. Clinical, physical and lifestyle indicators and relationship with cognition and mood in aging: a cross-sectional analysis of distinct educational groups

    Directory of Open Access Journals (Sweden)

    Nadine Correia Santos

    2014-02-01

    Full Text Available It is relevant to unravel the factors that may mediate the cognitive decline observed during aging. Previous reports indicate that education has a positive influence on cognitive performance, while age, female gender and, especially, depressed mood were associated with poorer performances across multiple cognitive dimensions (memory and general executive function. Herein, the present study aimed to characterize the cognitive performance of community-dwelling individuals within distinct educational groups categorized by the number of completed formal school years: less than 4, 4, completed primary education, and more than 4. Participants (n = 1051 were randomly selected from local health registries and representative of the Portuguese population for age and gender. Neurocognitive and clinical assessments were conducted in local health care centers. Structural equation modeling was used to derive a cognitive score, and hierarchical linear regressions were conducted for each educational group. Education, age and depressed mood were significant variables in directly explaining the obtained cognitive score, while gender was found to be an indirect variable. In all educational groups, mood was the most significant factor with effect on cognitive performance. Specifically, a depressed mood led to lower cognitive performance. The clinical disease indices cardiac and stroke associated with a more negative mood, while moderate increases in BMI, alcohol consumption and physical activity associated positively with improved mood and thus benefitted cognitive performance. Results warrant further research on the cause-effect (longitudinal relationship between clinical indices of disease and risk factors and mood and cognition throughout aging.

  19. RELATIONSHIP OF THE STAFF LOYALTY AND THE PERFORMANCE OF THE DENTAL CLINIC OF THE KRASNOYARSK STATE MEDICAL UNIVERSITY NAMED AFTER V.F. VOYNO-YASENETSKY

    Directory of Open Access Journals (Sweden)

    Татьяна Леонидовна Маругина

    2013-10-01

    Full Text Available We used the NPS methodology (Net Promoter Score developed by Fred Reichheld to determine loyalty of KRASSMU dental clinic staff. The method makes it possible using only 2 questions to evaluate not only the level of employees’ loyalty to the organization, but also to identify the approaches of increasing or retaining this level.The doctors, nurses, administrative and general service staff - all in all 60 employees were involved in the survey. As a result of the survey the level of NPS of the KRASSMU dental clinic staff is as following: 2.9% are promoters with a high degree of loyalty, 41.4% with an average degree of loyalty; the group of critics includes employees with a low degree of loyalty - 45.7%, totally not loyal - 10%. Thus the NPS index is -11.4%.Despite the negative NPS index the job performance standards of the dental clinic are increasing every year. It is achieved by the reward of the staff, satisfaction of needs, honest relationship in case of fulfillment of the terms of contract, the favorable environmental conditions in the workplace, as well as a qualitative monitoring the work of staff.DOI: http://dx.doi.org/10.12731/2218-7405-2013-9-30

  20. The Relationship of Clinical, Cognitive and Social Measures in Schizophrenia: A Preliminary Finding Combining Measures in Probands and Relatives

    Directory of Open Access Journals (Sweden)

    David Huepe

    2012-01-01

    Full Text Available This study examines performance of schizophrenia patients, unaffected relatives and controls in social cognition, cognitive and psychiatric scales looking for possible markers of vulnerability in schizophrenia. Performance of schizophrenia patients from multiplex families, first-degree relatives, and matched controls was compared and, subsequently, discriminant analysis method was used for identifying the best predictors for group membership. By using Multigroup Discriminant Analyses on the three groups, the best predictors were PANSS, Premorbid Adjustment Scale, Faux Pas test, and a face/emotion categorizing task. This model obtained 82% correct global classification, suggesting that the combination of psychiatric scales and neuropsychological/social cognition tesks are the best approach for characterizing this disease. Although preliminary, our results suggest that social cognition tasks are robust markers of schizophrenia family impairments, and that combining clinical, social and neuropsychological measures is the best approach to asses patients and relatives vulnerability.

  1. Methamphetamine-Associated Congestive Heart Failure: Increasing Prevalence and Relationship of Clinical Outcomes to Continued Use or Abstinence.

    Science.gov (United States)

    Sliman, Sean; Waalen, Jill; Shaw, David

    2016-10-01

    The purpose of this study was to determine the prevalence of methamphetamine-associated congestive heart failure (MAC) and to evaluate the relationship between methamphetamine abuse and EF and functional status over time. A retrospective review of records from 2009 to 2014 was carried out. Prevalence of methamphetamine abuse among all patients admitted with CHF was calculated for each of the 6 years of the study (n = 141) and was compared with prevalence of cocaine abuse and alcohol abuse. For patients with two or more admissions during the entire time period, the trajectories of NYHA functional class and EF over time were determined (n = 58). MAC has significantly increased from 1.8 to 5.6 % of total CHF patients admitted (n = 3705). Among patients who stopped using methamphetamine, NYHA functional class significantly improved, while among patients who continued methamphetamine use, NYHA was significantly worsened (p < 0.001). Significantly more patients with improved EF stopped using methamphetamine than continued (p = 0.05). There was a significant increase in the prevalence of MAC during the study period for all CHF patients admitted in our hospital system. Continued methamphetamine use is associated with worsening functional status, while cessation of methamphetamine is associated with improvement in functional status.

  2. Relationship Between Clinical and Immunological Features with Magnetic Resonance Imaging Abnormalities in Female Patients with Neuropsychiatric Systemic Lupus Erythematosus

    Institute of Scientific and Technical Information of China (English)

    Hai-Peng Wang; Cui-Yan Wang; Zheng-Lun Pan; Jun-Yu Zhao; Bin Zhao

    2016-01-01

    Background:Conventional magnetic resonance imaging (MRI) is the preferred neuroimaging method in the evaluation ofneuropsychiatric systemic lupus erythematosus (NPSLE).The purpose of this study was to investigate the association between clinical and immunological features with MRI abnormalities in female patients with NPSLE,to screen for the value of conventional MRI in NPSLE.Methods:A total of 59 female NPSLE patients with conventional MRI examinations were enrolled in this retrospective study.All patients were classified into different groups according to MRI abnormalities.Both clinical and immunological features were compared between MRI abnormal and normal groups.One-way analysis of variance was used to compare the systemic lupus erythematosus disease activity index (SLEDAI) score for MRI abnormalities.Multivariate logistic regression analysis investigated the correlation between immunological features,neuropsychiatric manifestations,and MRI abnormalities.Results:Thirty-six NPSLE patients (61%) showed a variety of MRI abnormalities.There were statistically significant differences in SLEDAI scores (P < 0.001),incidence of neurologic disorders (P =0.001),levels of 24-h proteinuria (P =0.001) and immunoglobulin M (P =0.004),and incidence of acute confusional state (P =0.002),cerebrovascular disease (P =0.004),and seizure disorder (P =0.028) between MRI abnormal and normal groups.In the MRI abnormal group,SLEDAI scores for cerebral atrophy (CA),cortex involvement,and restricted diffusion (RD) were much higher than in the MRI normal group (P < 0.001,P =0.002,P =0.038,respectively).Statistically significant positive correlations between seizure disorder and cortex involvement (odds ratio [OR] =14.90;95% confidence interval [CI],1.50-151.70;P =0.023) and cerebrovascular disease and infratentorial involvement (OR =10.00;95% CI,1.70-60.00;P =0.012) were found.Conclusions:MRI abnormalities in NPSLE,especially CA,cortex involvement,and RD might be markers of

  3. Relationship Between Metabolic Syndrome and Clinical Features, and Its Personal-Social Performance in Patients with Schizophrenia.

    Science.gov (United States)

    Saatcioglu, Omer; Kalkan, Murat; Fistikci, Nurhan; Erek, Sakire; Kilic, Kasim Candas

    2016-06-01

    The aim of this study was to evaluate the metabolic syndrome (MS) criteria and also to investigate the effects of MS on medical treatment, clinical course and personal and social performance in patients with schizophrenia. One hundred-sixteen patients with schizophrenia were included in the study. Measurements of MS were calculated in all patients. Brief Psychiatric Rating Scale, Scale for the Assessment of Positive Symptoms, Scale for the Assessment of Negative Symptoms, Calgary Depression Scale for Schizophrenia, Personal and Social Performance Scale (PSP) were applied. The frequency of MS according to IDF criteria was 42.2 % among the patients. There was no significant difference between patients with and without MS in terms of age. The ratios of MS were 62.5 % for the group taking typical and atypical antipsychotics together and 35.7 % for the group taking two or more atypical antipsychotics together. The duration of disorder in patients with MS was higher than those without MS. Furthermore there was no significant difference between the schizophrenic patients with and without MS, in terms of PSP scores. Our findings showed that the duration of illness, high scores of BMI, use of clozapine or concurrent use of typical and atypical antipsychotics, depressive and negative symptoms of schizophrenia were significant risk factors for the development of MS. PMID:26174109

  4. The relationship of initial clinical parameters to the long-term response in 112 cases of periodontal disease.

    Science.gov (United States)

    Wasserman, B; Hirschfeld, L

    1988-01-01

    The purpose of the present study was to determine whether any of the clinical parameters recorded during an initial periodontal examination would relate to the course of periodontal cases maintained for long periods of time. Based on available documentation, cases which had a downhill course were assembled from a population previously studied. In addition, long-term cases currently under maintenance care were drawn from our private practice. On average, the patients had been under care for 23 years. The study population was heavily weighted toward downhill cases to better compare these cases with those usually found in periodontal practice. Positive statistical correlations were found between the amount of subgingival calculus and the degree of gingival inflammation at initial examination. Disease severity initially was positively correlated to long-term course of disease. The amount of subgingival calculus did not relate to the long-term result. There was a strong correlation between inflammatory gingival hyperplasia initially and good long-term maintenance. The results suggest that, in combination, initial characteristics of periodontal cases coupled with long-term results of treatment may aid in further subclassifying the periodontal diseases.

  5. The relationship between serum antioxidant vitamins, magnesium levels, and clinical parameters in patients with primary fibromyalgia syndrome.

    Science.gov (United States)

    Sakarya, Sukran Tastan; Akyol, Yesim; Bedir, Abdulkerim; Canturk, Ferhan

    2011-08-01

    We proposed to assess serum antioxidant vitamins and magnesium (Mg) levels in patients with fibromyalgia (FM) in comparison to healthy controls. Additionally, the association between the serum antioxidant vitamins, magnesium levels, and clinical parameters in FM patients was also investigated. Forty female patients, aged between 30 and 50 years, were diagnosed with FM according to ACR-1990 criteria, and 40 healthy controls were included in the present study. Socio-demographic characteristics of participants, accompanying symptoms, and number of tender points (TP) of the patients were recorded. The intensity of pain was measured using the visual analogue scale (VAS). The functional status and depression levels were evaluated with Fibromyalgia Impact Questionnaire (FIQ) and Beck Depression Inventory (BDI), respectively. Serum vitamins A, C, and E and Mg levels were measured. There were no significant differences in the levels of vitamins A, C, and E and Mg between control subjects and patients with fibromyalgia (p > 0.05). In addition, no statistically significant correlations were found between mean levels of serum vitamins A, C, and E, and Mg and number of TP, scores of VAS, FIQ, and BDI in patients with FM (p > 0.05). According to the results of this study, it was asserted that other complex mechanism may play an important role in the pathophysiology of FM without plasma antioxidant vitamins and Mg levels. PMID:21347604

  6. Women with TSC: Relationship between Clinical, Lung Function and Radiological Features in a Genotyped Population Investigated for Lymphangioleiomyomatosis.

    Directory of Open Access Journals (Sweden)

    Fabiano Di Marco

    Full Text Available The advent of pharmacological therapies for lymphangioleiomyomatosis (LAM has made early diagnosis important in women with tuberous sclerosis complex (TSC, although the lifelong cumulative radiation exposure caused by chest computer tomography (CT should not be underestimated. We retrospectively investigated, in a cohort of TSC outpatients of San Paolo Hospital (Milan, Italy 1 the role of pulmonary function tests (PFTs for LAM diagnosis, 2 the association between LAM and other features of TSC (e.g. demography, extrapulmonary manifestations, genetic mutations, etc., and 3 the characteristics of patients with multifocal micronodular pneumocyte hyperplasia (MMPH. Eighty-six women underwent chest CT scan; pulmonary involvement was found in 66 patients (77%; 49% LAM with or without MMPH, and 28% MMPH alone. LAM patients were older, with a higher rate of pneumothorax, presented more frequently with renal and hepatic angiomyolipomas, and tended to have a TSC2 mutation profile. PFTs, assessed in 64% of women unaffected by cognitive impairments, revealed a lower lung diffusion capacity in LAM patients. In multivariate analysis, age, but not PFTs, resulted independently associated with LAM diagnosis. Patients with MMPH alone did not show specific clinical, functional or genetic features. A mild respiratory impairment was most common in LAM-TSC patients: In conclusions, PFTs, even if indicated to assess impairment in lung function, are feasible in a limited number of patients, and are not significantly useful for LAM diagnosis in women with TSC.

  7. Clinical significance of telomerase activity in peritoneal lavage fluid from patients with gastric cancer and its relationship with cellular proliferation

    Institute of Scientific and Technical Information of China (English)

    Ming-Xu Da; Xiao-Ting Wu; Tian-Kang Guo; Zi-Guang Zhao; Ting Luo; Kun Qian; Ming-Ming Zhang; Jie Wang

    2007-01-01

    AIM: To evaluate the efficacy of telomerase activity assay and peritoneal lavage cytology (PLC) examination in peritoneal lavage fluid for the prediction of peritoneal metastasis in gastric cancer patients, and to explore the relationship between telomerase activity and proliferating cell nuclear antigen expression.METHODS: Telomeric repeated amplification protocol (TRAP)-enzyme-linked immunosorbent assay (ELISA) was performed to measure the telomerase activity in 60 patients with gastric cancer and 50 with peptic ulcer. PLC analysis of the 60 patients with gastric cancer was used for comparison. The proliferating cell nuclear antigen (PCNA) in gastric carcinoma was immunohistochemically examined.RESULTS: The telomerase activity and PLC positive rate in peritoneal lavage fluid from patients with gastric cancer was 41.7% (25/60), and 25.0% (15/60), respectively. The positive rate of telomerase activity was significantly higher than that of PLC in the group Of pT4 (15/16 vs 9/16, P < 0.05), P1-3 (13/13 vs 9/13, P < 0.05) and diffuse type (22/42 vs 13/42, P < 0.05). The patients with positive telomerase activity, peritoneal metastasis, and serosal invasion had significantly higher levels of average PCNA proliferation index (PI), (55.00 ± 6.59 vs 27.43 ± 7.72, 57.26 ± 10.18 vs 29.15 ± 8.31, and 49.82 ± 6.74 vs 24;65 ± 7.33, respectively, P < 0.05).CONCLUSION: The TRAP assay for telomerase activity is a useful adjunct for cytologic method in the diagnosis of peritoneal micrometastasis and well related to higher proliferating activity of gastric cancer. The results of this study also suggest a promising future therapeutic strategy for treating peritoneal dissemination based on telomerase inhibition.

  8. Mast cells and acute coronary syndromes: relationship between serum tryptase, clinical outcome and severity of coronary artery disease

    Science.gov (United States)

    Morici, Nuccia; Farioli, Laura; Losappio, Laura Michelina; Colombo, Giulia; Nichelatti, Michele; Preziosi, Donatella; Micarelli, Gianluigi; Oliva, Fabrizio; Giannattasio, Cristina; Klugmann, Silvio; Pastorello, Elide Anna

    2016-01-01

    Objective To assess the relationship between serum tryptase and the occurrence of major cardiovascular and cerebrovascular events (MACCE) at 2-year follow-up in patients admitted with acute coronary syndrome (ACS). To compare serum tryptase to other validated prognostic markers (maximum high-sensitivity troponin (hs-Tn), C reactive protein (CRP) levels at admission, Synergy between percutaneous coronary intervention with Taxus and Cardiac Surgery (SYNTAX) score). Methods We measured serum tryptase at admission in 140 consecutive patients with ACS and in 50 healthy controls. The patients’ follow-up was maintained for 2 years after discharge. The predictive accuracy of serum tryptase for 2-year MACCE was assessed and compared with hs-Tn, CRP and SYNTAX score. Results Serum tryptase levels at admission were significantly higher in patients with ACS compared with the control group (p=0.0351). 2 years after discharge, 28/140 patients (20%) experienced MACCE. Serum tryptase levels, maximum hs-Tn measurements and SYNTAX score were higher in patients who experienced MACCE compared with those without (p<0.0001). Conversely, we found no significant association between MACCE and CRP. The predictive accuracy of serum tryptase for MACCE was set at the cut-off point of 6.7 ng/mL (sensitivity 46%, specificity 84%). Conclusions In patients with ACS, serum tryptase measured during index admission is significantly correlated to the development of MACCE up to 2 years, demonstrating a possible long-term prognostic role of this biomarker. PMID:27752333

  9. Conversion of the energy-subtracted CT number to electron density based on a single linear relationship: an experimental verification using a clinical dual-source CT scanner

    Science.gov (United States)

    Tsukihara, Masayoshi; Noto, Yoshiyuki; Hayakawa, Takahide; Saito, Masatoshi

    2013-05-01

    In radiotherapy treatment planning, the conversion of the computed tomography (CT) number to electron density is one of the main processes that determine the accuracy of patient dose calculations. However, in general, the CT number and electron density of tissues cannot be interrelated using a simple one-to-one correspondence. This study aims to experimentally verify the clinical feasibility of an existing novel conversion method proposed by the author of this note, which converts the energy-subtracted CT number (ΔHU) to the relative electron density (ρe) via a single linear relationship by using a dual-energy CT (DECT). The ΔHU-ρe conversion was performed using a clinical second-generation dual-source CT scanner operated in the dual-energy mode with tube potentials of 80 kV and 140 kV with and without an additional tin filter. The ΔHU-ρe calibration line was obtained from the DECT image acquisition for tissue substitutes in an electron density phantom. In addition, the effect of object size on ΔHU-ρe conversion was also experimentally investigated. The plot of the measured ΔHU versus nominal ρe values exhibited a single linear relationship over a wide ρe range from 0.00 (air) to 2.35 (aluminum). The ΔHU-ρe conversion performed with the tin filter yielded a lower dose and more reliable ρe values that were less affected by the object-size variation when compared to the corresponding values obtained for the case without the tin filter.

  10. Relationship between time to positivity of blood culture with clinical characteristics and hospital mortality in patients with Escherichia coli bacteremia

    Institute of Scientific and Technical Information of China (English)

    BO Shi-ning; BO Jian; NING Yong-zhong; ZHAO Yu; LU Xiao-lin; YANG Ji-yong; ZHU Xi; YAO Gai-qi

    2011-01-01

    Background Previous studies indicated that the time to positivity (TTP) of blood culture is a parameter correlating with degree of the bacteremia and outcome in patients with bloodstream infections caused by Escherichia coli (E.co/i). The objective of this study was to further investigate the diagnostic and prognostic power of using TTP to predict E. coli bacteremia.Methods A retrospective cohort study at two university hospitals was conducted. We retrieved all the medical records of those with E. coli bloodstream infection according to the records generated by their microbiology departments.Univariate and multivariate analyses were applied to identify clinical factors correlating with fast bacterial growth and significant prognostic factors for hospital mortality.Results Medical records of 353 episodes of E. coli bacteremia diagnosed between January 1,2007 and December 31,2009 were retrieved in the investigation. Univariate analysis demonstrated that the TTP≤7 hours group is associated with higher incidence of active malignancies (41.7% vs. 27.2%, P=0.010), neutropenia (30% vs.14.3%, P=0.007), primary bacteremia (55.0% vs. 33.4%, P=0.002), and poorer outcome (hospital mortality 43.3% vs.11.9%, P=0.000) than the TTP >7 hours group. Multivariate analysis revealed that the significant predictors of hospital mortality, in rank order from high to low, were TTP (for TTP <7 hours, odds ratio (OR): 4.886; 95% confidence interval (CI): 2.572-9.283; P=0.000),neutropenia (OR: 2.800; 95% CI:1.428-5.490; P=0.003), comedication of steroids or immunosuppressive agents (OR:2.670; 95% CI: 0.971-7.342; P=0.057).Conclusions Incidence of malignancies, neutropenia and primary bacterernia correlates with fast bacterial growth in patients with E. coli bacteremia. The parameter of TTP has been identified as a variable of highest correlation to hospital mortality and therefore can be potentially utilized as a mortality prognostic marker.

  11. Relationship between urinary albumin excretion rate and renal histology in non-insulin-dependent diabetes mellitus: with reference to the clinical significance of microalbuminuria.

    Science.gov (United States)

    Inomata, S; Nakamoto, Y; Inoue, M; Itoh, M; Ohsawa, Y; Masamune, O

    1989-01-01

    The present study demonstrates the relationship between urinary albumin excretion rate (AER) and renal structural changes in patients with non-insulin-dependent diabetes mellitus (NIDDM) without clinical proteinuria. Resting AER in 30 control subjects and 67 NIDDM patients were 10.4 +/- 4.8 (mean +/- SD) micrograms/min (range 4.3-21.1 micrograms/min) and 26.4 +/- 32.3 micrograms/min (range 0.4-155 micrograms/min), respectively. Persistent normoalbuminuria (less than 20 micrograms/min) and microalbuminuria (20-200 micrograms/min) were found in 43 (Group A) and 24 (Group B) diabetics. There were significant differences in age, diabetes duration, and frequency of retinopathy (background and proliferative) as well as that of proliferative retinopathy between Groups A and B, but not in the other clinical parameters such as body mass index, HbA1, Ccr, or systolic and diastolic blood pressure (SBP, DBP). When compared with 11 normoalbuminuric patients of similar age and equal diabetes duration to those in Group B, the sole difference in clinical parameters was the existence of proliferative retinopathy in Group B. Renal structural changes were investigated by light microscopy in 14 people in Group A and 13 people in Group B, and additionally in 5 NIDDM patients with both macroalbuminuria (greater than or equal to 200 micrograms/min) and normal or nearly normal renal function (Group C). The diffuse glomerular lesion (Gellman's classification) was grade I or II in A, II or III in B, and III in C.(ABSTRACT TRUNCATED AT 250 WORDS)

  12. Anti-Malassezia-Specific IgE Antibodies Production in Japanese Patients with Head and Neck Atopic Dermatitis: Relationship between the Level of Specific IgE Antibody and the Colonization Frequency of Cutaneous Malassezia Species and Clinical Severity

    OpenAIRE

    Enshi Zhang; Takafumi Tanaka; Mami Tajima; Ryoji Tsuboi; Hiroshi Kato; Akemi Nishikawa; Takashi Sugita

    2011-01-01

    Atopic dermatitis of the head and neck (HNAD) is recognized as a separate condition. Malassezia, the predominant skin microbiota fungus, is considered to exacerbate atopic dermatitis (AD), especially HNAD. In the present study, we investigated the relationships between the levels of specific IgE antibodies, colonization frequency of eight predominant Malassezia species, and clinical severity in 61 patients with HNAD (26 mild, 24 moderate, and 11 severe cases). As clinical severity increased, ...

  13. Craving for Food in Virtual Reality Scenarios in Non-Clinical Sample: Analysis of its Relationship with Body Mass Index and Eating Disorder Symptoms.

    Science.gov (United States)

    Ferrer-Garcia, Marta; Gutierrez-Maldonado, Jose; Treasure, Janet; Vilalta-Abella, Ferran

    2015-09-01

    Virtual reality (VR) technology has been successfully used to study the influence of specific and contextual food-related cues on emotional, cognitive and behavioural responses in patients with eating disorders (ED) and healthy controls. Following this research line, the present study assesses the effect on reported food craving of the type of food (low calorie versus high calorie) and the presence or absence of other people (private versus social context) in VR environments. Relationships between craving and body mass index (BMI) and ED symptoms are also explored. Eighty-seven female students were exposed to four VR scenarios presented in random order: a low-calorie kitchen, a high-calorie kitchen, a low-calorie restaurant and a high-calorie restaurant. After 2 minutes of exposure to each virtual scenario, food craving was assessed. Repeated measures analyses of covariance were conducted to assess changes in food craving following exposure to the different VR environments. Time elapsed since the last meal was introduced as a covariate to control for responses produced by food deprivation. Correlation and hierarchical multiple regression analyses were also conducted to assess the relationship between reported food craving and BMI and ED symptoms. Participants experienced higher levels of food craving after exposure to high-calorie foods (in both the kitchen and restaurant environments) than after exposure to low-calorie foods. Being alone in the kitchen or with friends in the restaurant had no effect on reported craving. Overall, neither BMI nor ED symptoms were related with reported food craving; only in the restaurant with low-calorie food was a significant negative correlation found between BMI and food craving. The results suggest that cue exposure in virtual environments is an effective procedure for inducing food craving in healthy controls and may be useful as a research and therapeutic tool in clinical populations. PMID:26095041

  14. Craving for Food in Virtual Reality Scenarios in Non-Clinical Sample: Analysis of its Relationship with Body Mass Index and Eating Disorder Symptoms.

    Science.gov (United States)

    Ferrer-Garcia, Marta; Gutierrez-Maldonado, Jose; Treasure, Janet; Vilalta-Abella, Ferran

    2015-09-01

    Virtual reality (VR) technology has been successfully used to study the influence of specific and contextual food-related cues on emotional, cognitive and behavioural responses in patients with eating disorders (ED) and healthy controls. Following this research line, the present study assesses the effect on reported food craving of the type of food (low calorie versus high calorie) and the presence or absence of other people (private versus social context) in VR environments. Relationships between craving and body mass index (BMI) and ED symptoms are also explored. Eighty-seven female students were exposed to four VR scenarios presented in random order: a low-calorie kitchen, a high-calorie kitchen, a low-calorie restaurant and a high-calorie restaurant. After 2 minutes of exposure to each virtual scenario, food craving was assessed. Repeated measures analyses of covariance were conducted to assess changes in food craving following exposure to the different VR environments. Time elapsed since the last meal was introduced as a covariate to control for responses produced by food deprivation. Correlation and hierarchical multiple regression analyses were also conducted to assess the relationship between reported food craving and BMI and ED symptoms. Participants experienced higher levels of food craving after exposure to high-calorie foods (in both the kitchen and restaurant environments) than after exposure to low-calorie foods. Being alone in the kitchen or with friends in the restaurant had no effect on reported craving. Overall, neither BMI nor ED symptoms were related with reported food craving; only in the restaurant with low-calorie food was a significant negative correlation found between BMI and food craving. The results suggest that cue exposure in virtual environments is an effective procedure for inducing food craving in healthy controls and may be useful as a research and therapeutic tool in clinical populations.

  15. Relationship between pathogenic, clinical, and virulence factors of Staphylococcus aureus in infective endocarditis versus uncomplicated bacteremia: a case-control study.

    Science.gov (United States)

    Gallardo-García, M M; Sánchez-Espín, G; Ivanova-Georgieva, R; Ruíz-Morales, J; Rodríguez-Bailón, I; Viñuela González, V; García-López, M V

    2016-05-01

    Pathogenic factors of Staphylococcus aureus (SA) in the development of infective endocarditis (IE) have not been sufficiently investigated. The purpose of this study was to analyze the pathogenesis and virulence factors of SA in patients with IE as compared to patients with uncomplicated bacteremia (un-BAC). This is a retrospective case-control study (2002-2014) performed at a tertiary hospital in Spain. Clinical and epidemiological factors were analyzed. We assessed the presence of toxin genes [toxic shock syndrome toxin 1 (tst-1) and enterotoxins A (etA), B (etB), and D (etD)] and the potential relationship between accessory gene regulator (agr) groups and the development of IE confirmed by polymerase chain reaction (PCR). Twenty-nine patients with IE were compared with 58 patients with uncomplicated S. aureus bacteremia (SAB). As many as 75.9 % of patients had community-acquired IE (p infection and severe sepsis or septic shock and IE. Also, a minimum inhibitory concentration (MIC) of vancomycin ≥1.5 μg/ml was found to be associated with IE. The agr group I was prevalent (55.2 % vs. 31.0 %; p = 0.030). No association was observed between toxin genes (tst-1, etA, etB, and etD) and IE. The superantigen (SAg) most frequently found in SA isolates was tst-1 (12.6 %). We found no association between toxin genes and IE, probably due to the small sample size. However, a direct relationship was found between agr I and the development of IE, which suggests that agr I strains may have more potential to cause IE. PMID:26951263

  16. The relationship between cognitive impairment and in vivo metabolite ratios in patients with clinical Alzheimer's disease and vascular dementia: a proton magnetic resonance spectroscopy study

    Energy Technology Data Exchange (ETDEWEB)

    Waldman, A.D. [Department of Imaging, Charing Cross Hospital and Dementia Research Group, University College London, Fulham Palace Road, W6 8RF, London (United Kingdom); Rai, G.S. [Department of Care of Older People, Whittington Hospital, Highgate Hill, London (United Kingdom)

    2003-08-01

    Previous magnetic resonance spectroscopy (MRS) studies have shown increased myo-inositol (MI) and decreased N-acetyl aspartate (NAA) levels in the parieto-occipital lobes of patients with Alzheimer's disease (AD) compared to those with other dementias and normal subjects. This study aimed to establish the quantitative relationship between metabolite ratios and degree of cognitive impairment in patients with mild to moderate AD and sub-cortical ischaemic vascular dementia (SIVD). Forty-four older people with clinical dementia were recruited from a memory clinic and followed up for 2.0-3.5 years; 20 cases were finally classified as probable AD, 18 as SIVD and 6 as mixed type. Mini Mental State Examination (MMSE) and short echo time single voxel automated MRS from the mesial parieto-occipital lobes were performed at the time of initial referral. Spearman rank correlation coefficients were calculated for MMSE scores and measured metabolite ratios MI/Cr, NAA/Cr, Cho/Cr and NAA/MI. The AD group showed a significant correlation between MMSE and NAA/MI (r=0.54, P=0.014) and NAA/Cr (r=0.48, P=0.033), and a negative, non-significant association with MI/Cr (r=-0.41, P=0.072). MI/Cr was negatively correlated with NAA/Cr (r=-0.51, P=0.021). Neither Cho/Cr ratios nor age correlated with cognitive function. The SIVD group showed no correlation between any of the measured metabolite ratios and MMSE score. This study reinforces the specific association between reduced NAA and increased MI levels in the parieto-occipital region and cognitive impairment in AD. MRS may have a role in evaluating disease progression and therapeutic monitoring in AD, as new treatments become available. (orig.)

  17. Investigation of the Relationship Between Gross Tumor Volume Location and Pneumonitis Rates Using a Large Clinical Database of Non-Small-Cell Lung Cancer Patients

    Energy Technology Data Exchange (ETDEWEB)

    Vinogradskiy, Yevgeniy, E-mail: yvinogra@mdanderson.org [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Tucker, Susan L. [Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Liao Zhongxing [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Martel, Mary K. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States)

    2012-04-01

    Purpose: Studies have suggested that function may vary throughout the lung, and that patients who have tumors located in the base of the lung are more susceptible to radiation pneumonitis. The purpose of our study was to investigate the relationship between gross tumor volume (GTV) location and pneumonitis rates using a large clinical database of 547 patients with non-small-cell lung cancer. Methods and Materials: The GTV centroids of all patients were mapped onto one common coordinate system, in which the boundaries of the coordinate system were defined by the extreme points of each individual patient lung. The data were qualitatively analyzed by graphing all centroids and displaying the data according to the presence of severe pneumonitis, tumor stage, and smoking status. The centroids were grouped according to superior-inferior segments, and the pneumonitis rates were analyzed. In addition, we incorporated the GTV centroid information into a Lyman-Kutcher-Burman normal tissue complication probability model and tested whether adding spatial information significantly improved the fit of the model. Results: Of the 547 patients analyzed, 111 (20.3%) experienced severe radiation pneumonitis. The pneumonitis incidence rates were 16%, 23%, and 21% for the superior, middle, and inferior thirds of the lung, respectively. Qualitatively, the GTV centroids of nonsmokers were notably absent from the superior portion of the lung. In addition, the GTV centroids of patients who had Stage III and IV clinical staging were concentrated toward the medial edge of the lung. The comparison between the GTV centroid model and the conventional dose-volume model did not yield a statistically significant difference in model fit. Conclusions: Lower pneumonitis rates were noted for the superior portion of the lung; however the differences were not statistically significant. For our patient cohort, incorporating GTV centroid information did not lead to a statistically significant improvement

  18. The relationship between Interleukin 18 expression in laryngeal squamous cell carcinoma and clinical pathology as well as the effect of cetuximab on its expression

    Institute of Scientific and Technical Information of China (English)

    Xiu-Ping Liao; Nian Lyu; Sen-Lan Long

    2015-01-01

    Objective:To explore the relationship between Interleukin 18 (IL-18) expression in laryngeal squamous cell carcinoma and clinical pathology as well as the effect of cetuximab on its expression.Methods:40 cases of patients with laryngeal squamous cell carcinoma from January 2010 to June 2014 were chosen as the research group; 40 cases of patients with vocal cord polyp and 40 healthy volunteers were chosen as the control group. Statistical analysis was carried out on clinical pathology of laryngeal squamous cell carcinoma. IL-18, IFN-γ, TNF-αand IL-6 levels in peripheral blood mononuclear cells before and after cetuximab application were detected.Results:Detected IL-18 values of laryngeal squamous cell carcinoma group were higher than those of adjacent cancer tissue and vocal cord polyps; IL-18 positive rate (75.0%) of laryngeal squamous cell carcinoma group was higher than that of adjacent cancer tissue (47.5%) and polyp tissue (37.5%); IL-18 expressions of laryngeal squamous cell carcinoma group were related to primary lesion staging, differentiation degree and lymph node metastasis; before cetuximab application, IL-18 levels were significantly higher than those of the control group, and after cetuximab application, IL-18 levels significantly decreased than before. Differences were statistically significant; after cetuximab application, IFN-γ, TNF-αand IL-6 levels in PBMCs supernatant of patients with laryngeal squamous cell carcinoma were significantly lower than before. Differences were statistically significant.Conclusion:IL-18 can be highly expressed in laryngeal squamous cell carcinoma; IL-18 expression is involved in the occurrence and progress of laryngeal squamous cell carcinoma; IL-18 is possible to be involved in the occurrence and progress of laryngeal squamous cell carcinoma through regulating expressions of IFN-γ, TNF-α and IL-6, etc; IL-18 can be used as a target of laryngeal squamous cell carcinoma treatment, and cetuximab can inhibit IL-18

  19. Relationship between nasolaryngoscopic findings and pH probe esophageal monitoring in children with clinical manifestations of extra-esophageal reflux

    Directory of Open Access Journals (Sweden)

    Oliveira, Neide Fatima Cordeiro Diniz

    2009-06-01

    Full Text Available Introduction: The gastroesophageal reflux diagnosis, mainly in patients with atypical manifestations, has been receiving increasing importance. Objective: To relate the nasolaryngoscopic findings with prolonged pH probe esophageal monitoring in children with clinical manifestations of extra-esophageal reflux. Method: Transversal prospective clinical study, in which we evaluated 44 children from one to 12 years old, of both genders, by means of nasolaryngoscopy. All were submitted to pH probe monitoring for research of hidden reflux due to cases of otitis, sinusitis, asthma, laryngitis and/or dysphonia in the last 12 months. Results: Out of 44 children, 15 (34% presented with normal pH monitoring and 29 (66% with altered monitoring. Out of 29 with altered pH monitoring, 19 (65.5% were boys and 10 (34.5% were girls. There was no statistically significant difference between gender and the positive results of pH monitoring, in spite of a discreet predominance of occurrence in the male population. All children had smaller adenoids than 75% of the cavity of concha aerial column. Six presented with purulent secretion in nasal cavity. Eight (18% had nodes in vocal cords and five (11% of whom had an altered pH monitoring and three (7% of whom were normal. We found at least one alteration upon nasolaryngoscopy in 80% of the 15 children with normal pH monitoring and in 89.7% of the 29 who had an altered pH monitoring. Conclusion: The prevalence of gastroesophageal reflux in children with recurrent respiratory and otorhinolaryngological affections was high. However, the data obtained didn't show any statistically significant difference (p<0.05 among the nasolaryngoscopic findings, associated or not with gastroesophageal reflux, confirmed by pH monitoring. Therefore, no relationship was found between the pathological gastric acid reflux and nasolaryngoscopic alterations.

  20. Investigation of the Relationship Between Gross Tumor Volume Location and Pneumonitis Rates Using a Large Clinical Database of Non-Small-Cell Lung Cancer Patients

    International Nuclear Information System (INIS)

    Purpose: Studies have suggested that function may vary throughout the lung, and that patients who have tumors located in the base of the lung are more susceptible to radiation pneumonitis. The purpose of our study was to investigate the relationship between gross tumor volume (GTV) location and pneumonitis rates using a large clinical database of 547 patients with non–small-cell lung cancer. Methods and Materials: The GTV centroids of all patients were mapped onto one common coordinate system, in which the boundaries of the coordinate system were defined by the extreme points of each individual patient lung. The data were qualitatively analyzed by graphing all centroids and displaying the data according to the presence of severe pneumonitis, tumor stage, and smoking status. The centroids were grouped according to superior–inferior segments, and the pneumonitis rates were analyzed. In addition, we incorporated the GTV centroid information into a Lyman–Kutcher–Burman normal tissue complication probability model and tested whether adding spatial information significantly improved the fit of the model. Results: Of the 547 patients analyzed, 111 (20.3%) experienced severe radiation pneumonitis. The pneumonitis incidence rates were 16%, 23%, and 21% for the superior, middle, and inferior thirds of the lung, respectively. Qualitatively, the GTV centroids of nonsmokers were notably absent from the superior portion of the lung. In addition, the GTV centroids of patients who had Stage III and IV clinical staging were concentrated toward the medial edge of the lung. The comparison between the GTV centroid model and the conventional dose–volume model did not yield a statistically significant difference in model fit. Conclusions: Lower pneumonitis rates were noted for the superior portion of the lung; however the differences were not statistically significant. For our patient cohort, incorporating GTV centroid information did not lead to a statistically significant

  1. Relationships between PON1 Q192R polymorphism and clinical outcome of antiplatelet treatment after percutaneous coronary intervention: a meta-analysis.

    Science.gov (United States)

    Li, Ping; Bu, Shu-Hong; Lu, Xiao-Tong; Li, Li-Xia; Xu, A-Jing; Tang, Yue-Nian; Zhang, Jian

    2014-09-01

    This meta-analysis was performed to assess the relationships between the PON1 Q192R (rs662 T>C) polymorphism and the clinical outcome of antiplatelet treatment after percutaneous coronary intervention (PCI). A range of electronic databases were searched: Web of Science (1945-2013), the Cochrane Library Database (Issue 12, 2013), PubMed (1966-2013), EMBASE (1980-2013), CINAHL (1982-2013) and the Chinese Biomedical Database (CBM) (1982-2013) without language restrictions. Meta-analysis was conducted using the STATA 12.0 software. The crude odds ratio (OR) with their 95 % confidence interval (CI) were calculated. Six clinical cohort studies with a total number of 5,189 patients undergoing PCI for coronary heart disease were included. Our meta-analysis revealed that the PON1 Q192R polymorphism was correlated with an increased risk of major adverse cardiovascular events (MACE) in patients receiving antiplatelet treatment after PCI (C allele vs. T allele: OR = 1.22, 95 % CI 1.04-1.43, P = 0.014; CT+CC vs. TT: OR = 1.38, 95 % CI 1.03-1.86, P = 0.029; CC vs. TT: OR = 1.45, 95 % CI 1.05-1.99, P = 0.024; respectively), especially among Asians. Furthermore, we found significantly positive correlations between the PON1 Q192R polymorphism and the incidence of stent thrombosis in patients receiving antiplatelet treatment after PCI (C allele vs. T allele: OR = 1.42, 95 % CI 1.08-1.87, P = 0.011; CT+CC vs. TT: OR = 1.93, 95 % CI 1.01-3.67, P = 0.046; CC vs. TT: OR = 2.18, 95 % CI 1.09-4.35, P = 0.027; respectively). Our meta-analysis of clinical cohort studies provides evidence that the PON1 Q192R polymorphism may increase the risk of MACE and stent thrombosis in patients receiving antiplatelet treatment after PCI.

  2. The relationship of mucosal bacteria to duodenal histopathology, cytokine mRNA, and clinical disease activity in cats with inflammatory bowel disease.

    Science.gov (United States)

    Janeczko, S; Atwater, D; Bogel, E; Greiter-Wilke, A; Gerold, A; Baumgart, M; Bender, H; McDonough, P L; McDonough, S P; Goldstein, R E; Simpson, K W

    2008-04-01

    Feline inflammatory bowel disease (IBD) is the term applied to a group of poorly understood enteropathies that are considered a consequence of uncontrolled intestinal inflammation in response to a combination of elusive environmental, enteric microbial, and immunoregulatory factors in genetically susceptible cats. The present study sought to examine the relationship of mucosal bacteria to intestinal inflammation and clinical disease activity in cats with inflammatory bowel disease. Duodenal biopsies were collected from 27 cats: 17 undergoing diagnostic investigation of signs of gastrointestinal disease, and 10 healthy controls. Subjective duodenal histopathology ranged from normal (10), through mild (6), moderate (8), and severe (3) IBD. The number and spatial distribution of mucosal bacteria was determined by fluorescence in situ hybridization with probes to 16S rDNA. Mucosal inflammation was evaluated by objective histopathology and cytokine profiles of duodenal biopsies. The number of mucosa-associated Enterobacteriaceae was higher in cats with signs of gastrointestinal disease than healthy cats (Pcats. These data establish that the density and composition of the mucosal flora is related to the presence and severity of intestinal inflammation in cats and suggest that mucosal bacteria are involved in the etiopathogenesis of feline IBD.

  3. Episodes of clinical mastitis and its relationship with duration of treatment and seasonality in crossbred cows maintained in organized dairy farm

    Directory of Open Access Journals (Sweden)

    Narender Kumar

    2016-01-01

    Full Text Available Aim: Present study aimed to evaluate the different episodes of clinical mastitis (CM and influence of duration of treatment and seasonality on the occurrence of different episodes of CM in crossbred cows. Materials and Methods: A total of 1194 lactation data of crossbred CM cows were collected from mastitis treatment record from 2002 to 2012. Data of CM cows were classified into types of episodes (pattern of repeated or multiple episodes occurrence and number of episodes (magnitude of multiple cases. Types of episodes were divided as single (clinical cure by a single episode of treatment, relapse (retreatment of the same cow within 21 days, recurrence (new CM at least 21 days after treatment, and both (relapse and recurrence. The season was classified as winter (December to March, summer (April to June, rainy (July to September, and autumn (October to November. The difference between incidences of different types of CM episodes and the association between number or type of CM episodes with duration of treatment and seasons of CM occurrence were analyzed by Chi-square test. Results: Among 1194 animals suffered with CM, 53, 16, and 18% had the single episode, relapse, and recurrence, respectively; while 13% suffered by both relapse and recurrence. We estimated the duration of treatment and found 80% of the cows treated 1-8 days, in which 65% treated for 1-4 days, while 35% cows were treated for 5-8 days. Further, 12% cows treated for 9-15 days and 7.5% cows treated >15 days. The relationship between duration of treatment and different episodes of CM revealed that 1-8 days treated cows were mostly cured by the single episode with less relapse and recurrence. In contrast, the incidences of recurrence and relapse episodes were higher in cows treated for more than 9 days. The highest incidence of relapse was noticed in winter (36% than other seasons (10-28%, while the recurrence was less during autumn (9% compared to other seasons (20-40%. Conclusion

  4. The relationship between IQ, memory, executive function, and processing speed in recent-onset psychosis: 1-year stability and clinical outcome.

    Science.gov (United States)

    Leeson, Verity C; Barnes, Thomas R E; Harrison, Masuma; Matheson, Elizabeth; Harrison, Isobel; Mutsatsa, Stanley H; Ron, Maria A; Joyce, Eileen M

    2010-03-01

    Studies commonly report poor performance in psychotic patients compared with controls on tasks testing a range of cognitive functions, but, because current IQ is often not matched between these groups, it is difficult to determine whether this represents a generalized deficit or specific abnormalities. Fifty-three first-episode psychosis patients and 53 healthy controls, one-to-one matched for sex, age, and full-scale current IQ, were compared on Wechsler Adult Intelligence Scale (WAIS) subtests representing indices of perceptual organization, verbal comprehension, processing speed, and working memory as well as other tests of executive function and episodic memory. The groups showed an equivalent pattern of performance on all WAIS subtests except digit symbol processing speed, on which the patients were significantly worse. Patients were also worse on measures where performance correlated with digit symbol score, namely working and verbal memory tasks. Standardized residual scores for each subtest were calculated for each patient using the difference between their actual subtest score and a predicted subtest score based on their full-scale IQ and the performance of controls. Scaled scores and residual scores were examined for relationships with clinical measures. Digit symbol-scaled score was significantly correlated with concurrent negative syndrome score at baseline, and digit symbol residual score significantly predicted residual negative symptoms at 1-year follow-up. In summary, our comparison of patients and controls precisely matched for IQ revealed that processing speed was attenuated in recent-onset schizophrenia, contributed significantly to working and episodic memory deficits, and was a prognostic factor for poor outcome at 1 year. PMID:18682375

  5. A STUDY OF SOME PARAMETERS OF THE EXTERNAL RESPIRATORY FUNCTION AND THEIR RELATIONSHIP TO THE CLINICAL ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS

    Directory of Open Access Journals (Sweden)

    D. V. Bestaev

    2014-06-01

    Full Text Available Pulmonary pathology is diagnosed in patients with rheumatoid arthritis (RA. The external respiratory function (ERF examination is widely used to assess the functional capacity of the lungs. Objective. To evaluate ERF in patients with RA. Material and methods. The study included 155 patients with RA. A MasterScreen Body plethysmograph (Erich Jaeger was used to determine the ERF parameters (diffusing lung capacity, DLC; forced inspiratory vital capacity, FIVC; forced expiratory volume in 1 second, FEV1; total lung capacity, TLC; the FEV1/FIVC ratio, and the modified Tiffeneau index. DLC was measured by the single-breath method. ERF parameters were represented as a percentage of the appropriate value for a given gender, age, and height of the patient. Results. Of the 155 examined patients with RA, a decrease in the DLC parameter was detected in 107 (69%, while in 87 (81% patients, the decrease was less than 10% of the proper values. An analysis of the state of the ERF parameters revealed a decrease in FEV1 in 48 (31% patients, FIVC in 41 (27% patients, and TLC in 36 (23% patients. The restrictive type of lung ventilation was determined in 27% of patients, bronchial obstruction in 31% of patients, an iso- lated decrease in DLC in 12% of patients with RA. In 31% of cases, no deviations of the ERF parameters from normal values were found. A statistically significant negative correlation between the clinical activity of RA and the DLC level (r = -0.59; p<0.05 was found. Conclusion. The study revealed a high frequency of variation in the ERF parameters in patients with RA. In most cases, the variation was demonstrated by DLC. The obstructive changes were prevalent among RA patients. The high percentage of smokers among RA patients with the obstructive type of ventilation may indicate the influence of smok- ing on the development of bronchial obstruction. Our work revealed the significant relationship between the degree of RA activity and the DLC value.

  6. Determining Whether a Definitive Causal Relationship Exists Between Aripiprazole and Tardive Dyskinesia and/or Dystonia in Patients With Major Depressive Disorder, Part 3: Clinical Trial Data.

    Science.gov (United States)

    Preskorn, Sheldon H; Macaluso, Matthew

    2016-03-01

    This series of columns has 3 main goals: (1) to explain class warnings as used by the United States Food and Drug Administration, (2) to increase awareness of movement disorders that may occur in patients treated with antipsychotic medications, and (3) to understand why clinicians should refrain from immediately assuming a diagnosis of tardive dyskinesia/dystonia (TD) in patients who develop abnormal movements during treatment with antipsychotics. The first column in the series presented a patient who developed abnormal movements while being treated with aripiprazole as an augmentation strategy for major depressive disorder (MDD) and reviewed data concerning the historical background, incidence, prevalence, and risk factors for tardive and spontaneous dyskinesias, the clinical presentations of which closely resemble each other. The second column in the series reviewed the unique mechanism of action of aripiprazole and preclinical studies and an early-phase human translational study that suggest a low, if not absent, risk of TD with aripiprazole. This column reviews clinical trial data to assess whether those data support the conclusion that aripiprazole has a low to absent risk of causing TD when used as an augmentation strategy to treat MDD. To date, no randomized, placebo-controlled trials have established a definitive link between exposure to aripiprazole and TD in patients with MDD. One long-term, open-label, safety trial examined aripiprazole as an augmentation strategy in individuals with MDD and found a rare occurrence (4/987, 0.4%, the confidence interval of which overlaps with zero) of an adverse event termed TD. In all 4 cases, the observed movements resolved within weeks of aripiprazole discontinuation, suggesting that they were either amenable to treatment or represented an acute syndrome rather than TD. No cases of TD were reported in the registration trials for the MDD indication for aripiprazole. These data were presented in a pooled analysis of

  7. Clinical Analysis of the Relationship between Cirrhosis and Hepatic Diabetes%肝硬化与肝源性糖尿病临床关系分析

    Institute of Scientific and Technical Information of China (English)

    李洪昌; 陈丽虹; 廖浩峰

    2015-01-01

    Objective:To investigate the relationship between cirrhosis and hepatic diabetes.Method:42 cases of liver cirrhosis complicated by diabetes as the observation group,the same period 40 cases of cirrhosis without diabetes mellitus as the control group.The clinical manifestations of the two groups,liver function in cirrhotic patients before and after treatment in diabetic patients with cirrhosis fasting glucose,TB,ALT and occurrence of complications were compared and analyzed.Result:The polydipsia,polyphagia,polyuria and anorexia of the observation group were significantly more than those of the control group,and there were significant differences(P<0.05).The blood sugar level to normal in the majority,while the Class B with hepatic diabetes common.cirrhotic patients with diabetes treated a month of fasting blood glucose,TB,ALT were significantly lower than before treatment,and there were statistically significant differences(P<0.05).Hepatic encephalopathy,hepatorenal syndrome,spontaneous bacterial peritonitis of the observation group were significantly more than those of the control group,and there were statistically significant differences(P<0.05).Conclusion:Cirrhosis and hepatic diabetes is closely related to liver cirrhosis clinical manifestations in diabetic patients is more complex,takes active and effective in the treatment of primary liver disease is particularly important with strict control of blood sugar,can reduce complications, has important significance.%目的:探讨肝硬化与肝源性糖尿病的临床关系。方法:选择42例肝硬化并发糖尿病患者作为观察组,选择同期40例肝硬化未并发糖尿病患者作为对照组。对比分析两组患者临床表现,肝硬化患者肝功能分级,肝硬化糖尿病患者治疗前后空腹血糖、TB、ALT及并发症发生情况。结果:观察组多饮、多食、多尿及纳差患者均显著多于对照组,且差异均有统计学意义(P<0.05);A级以对照组居多,

  8. The Relationship between Caregiver Burden, Demographic Variables, and the Clinical Characteristics of Patients with Parkinson’s Disease – A systematic Review of Studies Using Various Caregiver Burden Instruments

    OpenAIRE

    Leiknes, Ingrid; Lien, Unn-Tone; Severinsson, Ingeborg Elisabeth

    2015-01-01

    Caring for a person with Parkinson’s disease (PD) extends far beyond the ordinary exchange of assistance among people in a close relationship. Caregivers must learn to cope with the patient’s increasing disability and loss of independence. The aim of this systematic review was to critically assess and summarize the evidence of the influence of the demographic and clinical characteristics of patients with PD on caregiver burden by means of a caregiver burden instrument. In order to identify...

  9. Anti-Malassezia-Specific IgE Antibodies Production in Japanese Patients with Head and Neck Atopic Dermatitis: Relationship between the Level of Specific IgE Antibody and the Colonization Frequency of Cutaneous Malassezia Species and Clinical Severity

    Directory of Open Access Journals (Sweden)

    Enshi Zhang

    2011-01-01

    Full Text Available Atopic dermatitis of the head and neck (HNAD is recognized as a separate condition. Malassezia, the predominant skin microbiota fungus, is considered to exacerbate atopic dermatitis (AD, especially HNAD. In the present study, we investigated the relationships between the levels of specific IgE antibodies, colonization frequency of eight predominant Malassezia species, and clinical severity in 61 patients with HNAD (26 mild, 24 moderate, and 11 severe cases. As clinical severity increased, the levels of specific IgE antibodies against eight Malassezia species also increased. Species diversity of the Malassezia microbiota in scale samples from patients was analyzed by nested PCR using species-specific primers. The clinical severity of HNAD was correlated with the total level of specific IgE antibodies against Malassezia species and the number of Malassezia species detected.

  10. Relationship between Para Clinical Findings of First Seizure and One Year Recurrence Rate in Children Admitted at Shaheed Sadoughi Hospital-Yazd

    OpenAIRE

    N Owaisi; Z Eslami; M. Golestan; M Sadr- Bafghi; R Fallah; Akhavan Karbasi, S

    2007-01-01

    Introduction: Seizure is the most common pediatric neurology problem that occurs in 10% of children. The purpose of this study was to determine the recurrence rate of seizures after one year and its relationship with paraclinical findings of the first attack. Methods : In a historical cohort analytic study , 131 children with first seizure admitted to Shaheed Sadoughi Hospital between March 2004 to August 2005 were evaluated for recurrence rate during one year and its relationship with serum ...

  11. The Relationship between Self-Efficacy for Behaviors that Promote Healthy Weight and Clinical Indicators of Adiposity in a Sample of Early Adolescents

    Science.gov (United States)

    Steele, Michael M.; Daratha, Kenn B.; Bindler, Ruth C.; Power, Thomas G.

    2011-01-01

    Objective: Examine the relationship between self-efficacy and various measures of adiposity in a sample of teens. Methods: A total of 132 teens were selected from schools participating in an existing research study titled Teen Eating and Activity Mentoring in Schools (TEAMS). Teens completed demographic questionnaires and healthy eating-specific…

  12. Students' Reflections on the Relationships between Safe Learning Environments, Learning Challenge and Positive Experiences of Learning in a Simulated GP Clinic

    Science.gov (United States)

    Young, J. E.; Williamson, M. I.; Egan, T. G.

    2016-01-01

    Learning environments are a significant determinant of student behaviour, achievement and satisfaction. In this article we use students' reflective essays to identify key features of the learning environment that contributed to positive and transformative learning experiences. We explore the relationships between these features, the students'…

  13. Relationship Between the Clinical Components of the Boder Test of Reading-Spelling Patterns and the Stanford Achievement Test: Validity of the Boder.

    Science.gov (United States)

    Hooper, Stephen R.

    1988-01-01

    Investigated the concurrent validity of the diagnostic components of the Boder Test of Reading-Spelling Patterns with the reading and spelling measures of the Stanford Achievement Reading Test (SAT) in 87 reading-disabled elementary school students. Results indicated the relationship between the reading components of the Boder and SAT were…

  14. Childhood adversity as a moderator of the relationship between emotional reactivity and the occurrence of anxiety and depression in a non-clinical group

    Directory of Open Access Journals (Sweden)

    Wojciech Łukasz Dragan

    2016-02-01

    The obtained results are only partially explained within the temperamental risk factor model. A different pattern of relationships between the intensity of the temperamental trait and the occurrence of anxiety and depression depending on the amount of reported adversity may result from the cumulative effect of the negative consequences of this type of experience.

  15. Systematic review and meta-analysis: the relationship between the Helicobacter pylori dupA gene and clinical outcomes

    OpenAIRE

    Shiota Seiji; Matsunari Osamu; Watada Masahide; Hanada Katsuhiro; Yamaoka Yoshio

    2010-01-01

    Abstract Background In 2005, the first disease-specific Helicobacter pylori virulence factor that induced duodenal ulcer and had a suppressive action on gastric cancer has been identified, and was named duodenal ulcer promoting gene (dupA). However, the importance of the dupA gene on clinical outcomes is conflicting in subsequent studies. The aim of this study was to estimate the magnitude of the risk for clinical outcomes associated with dupA gene. Methods A meta-analysis of case-control stu...

  16. Expression and Effects of Oncostatin M and Its Receptor in Hepatocellular Carcinoma Tissues and the Relationship between Clinical Data%原发性肝细胞癌OSM、OSMR表达与临床资料关系及意义

    Institute of Scientific and Technical Information of China (English)

    钱俊甫

    2014-01-01

    ObjectiveTo resarech the expression of oncostatin M and its receptor in hepatocellular carcinoma tissues,tissues surrounding hepatoma and the relationship between clinical data, to explore possiblely mechanisms and signiifcance by which they affect hepatocellular carcinoma.MethodsELISA immunohistochemistry and ELISA absorbance method was used to detect the expression of oncostatin M and its receptor in hepatocellular carcinoma tissues and tissues surrounding hepatoma in 30 patients with corroborative HCC thyough pathology , 5 normal liver tissue and 6 cases tissue of Hemangiomas. Routinely testing the level of AFP, AST, ALT, TBIL in patients with preoperative serum, distinguishing different groups by sex, age, Child classiifcation, AFP, HBsAg, liver cirrhosis, TNM stage, tumor pseudocapsule situation whether in 30 cases patients with HCC. Analysised the relationship between clinical data and oncostatin M and its receptor in hepatocellular carcinoma tissues,tissues surrounding hepatoma by variance analysis and Logistic regression, to resarech expression and effects of oncostatin M and its receptor in hepatocellular carcinoma tissues and the relationship between clinical data.Results①The expression of OSM and OSMR in hepatocellular carcinoma tissues and tissues surrounding hepatoma are unrelated with the groups of sex, age, Child classiifcation, HBsAg, liver cirrhosis in patients with HCC(P>0.05).②The expression of OSM and OSMR in hepatocellular carcinoma tissues and tissues surrounding hepatoma are interrelated with the AFP,TNM stage, tumor pseudocapsule situation whether in patients with HCC(P0.05);②肝癌及癌旁组织中OSM、OSMR表达与AFP、TNM分期、肿瘤有无假包膜相关(P<0.05)。结论 OSM、OSMR与HCC发生、发展密切相关;肝癌及癌旁组织中OSM、OSMR表达与AFP、TNM分期、肿瘤无假包膜密切相关。

  17. Symptoms of anxiety, depression, and aggression in non-clinical children: Relationships with self-report and performance-based measures of attention and effortful control

    NARCIS (Netherlands)

    P.E.H.M. Muris (Peter); E. van der Pennen (Els); R. Sigmond (Rianne); B.N. Mayer (Birgit)

    2008-01-01

    textabstractThis study investigated the relation between the regulative trait of effortful control, and in particular attention control, and psychopathological symptoms in a sample of 207 non-clinical children aged 8-12 years. For this purpose, children completed self-report scales for measuring reg

  18. Symptoms of Anxiety, Depression, and Aggression in Non-Clinical Children: Relationships with Self-Report and Performance-Based Measures of Attention and Effortful Control

    Science.gov (United States)

    Muris, Peter; van der Pennen, Els; Sigmond, Rianne; Mayer, Birgit

    2008-01-01

    This study investigated the relation between the regulative trait of effortful control, and in particular attention control, and psychopathological symptoms in a sample of 207 non-clinical children aged 8-12 years. For this purpose, children completed self-report scales for measuring regulative traits and various types of psychopathological…

  19. Is anti-doping analysis so far from clinical, legal or forensic targets?: The added value of close relationships between related disciplines.

    Science.gov (United States)

    Segura, Jordi

    2009-11-01

    There are many areas of common interest between anti-doping laboratories and those working in the clinical, legal and forensic fields. In addition to methodological similarities, there are aspects of the findings in sport drug testing that overlap with other fields in such a way that sport drug testing and clinical, legal or forensic work may benefit from mutual interaction. Three recent examples are presented from the author's experience. Case report 1 concerns the clinical relevance of hCG findings in sport drug testing as potential indicators of the presence of a (testicular) tumour in athletes. Case report 2 refers to difficulties that accredited laboratories can encounter due to differences between national legal systems and the administrative regulation systems of sport authorities. The example involves a network of blood collection for further autologous transfusion. Case report 3 relates to additional forensic-type investigations needed to interpret a situation where intoxication of a whole delegation was responsible for apparent doping cases. Clinical, legal and forensic fields must recognize the added value that some results and developments coming from anti-doping laboratories may have. At the same time anti-doping analysts should be aware of new issues, methodologies and problems appearing in related fields.

  20. On Better Estimating and Normalizing the Relationship between Clinical Parameters: Comparing Respiratory Modulations in the Photoplethysmogram and Blood Pressure Signal (DPOP versus PPV)

    OpenAIRE

    2015-01-01

    DPOP (ΔPOP or Delta-POP) is a noninvasive parameter which measures the strength of respiratory modulations present in the pulse oximeter waveform. It has been proposed as a noninvasive alternative to pulse pressure variation (PPV) used in the prediction of the response to volume expansion in hypovolemic patients. We considered a number of simple techniques for better determining the underlying relationship between the two parameters. It was shown numerically that baseline-induced signal error...

  1. Helium ventilation in obstructive respiratory diseases : evaluation of ventilation/perfusion relationships with the MIGET : from the animal model to the clinical application

    OpenAIRE

    Watremez, Christine

    2010-01-01

    To briefly guide the reader along this thesis on the contribution of helium ventilation in bronchospastic diseases, we provide a short outline in five steps as following: - First, we will review briefly the basis of asthma disease and COPD. - Second, we will describe some respiratory measurements we have at one’s disposal to evaluate the level of the disease and the extent of therapy effect. - Third, we will make a recall of measurement of the ventilation-perfusion relationships by t...

  2. Atopy patch tests in young adult patients with atopic dermatitis and controls: dose-response relationship, objective reading, reproducibility and clinical interpretation

    DEFF Research Database (Denmark)

    Bygum, Anette; Mørtz, Charlotte G; Andersen, Klaus Ejner

    2003-01-01

    The clinical interpretation and reproducibility of atopy patch tests was studied in 23 selected young adult patients with atopic dermatitis and 25 healthy controls using standard inhalant allergens. Non-invasive measurements were used for objective assessment of test reactions and the participants...... were retested after 6 weeks. Ten of 19 (53%) evaluable patients with atopic dermatitis had at least one positive atopy patch test. However, there was no clear clinical relevance of the atopy patch test results when related to patient history and distribution of dermatitis. Reproducible and dose......-dependent results were obtained with Dermatophagoides pteronyssinus, grass and cat with a reproducibility rate of 0.69 to 0.81 in patients and 0.60-0.96 in controls. A unique finding was a significant positive correlation between a positive atopy patch test, allergen dose and increase in transepidermal water loss...

  3. Relationships between high-stakes clinical skills exam scores and program director global competency ratings of first-year pediatric residents

    OpenAIRE

    Langenau, Erik E.; Pugliano, Gina; Roberts, William L.

    2011-01-01

    Background: Responding to mandates from the Accreditation Council for Graduate Medical Education (ACGME) and American Osteopathic Association (AOA), residency programs have developed competency-based assessment tools. One such tool is the American College of Osteopathic Pediatricians (ACOP) program directors’ annual report. High-stakes clinical skills licensing examinations, such as the Comprehensive Osteopathic Medical Licensing Examination Level 2-Performance Evaluation (COMLEX-USA Le...

  4. Clinical significance of serum carbohydrate antigen 19-9 and its relationship with blood glucose in patients with type 2 diabetes

    Institute of Scientific and Technical Information of China (English)

    武秀玲

    2013-01-01

    Objective To study the relationship between serum carbohydrate antigen 19-9 (CA19-9) and blood glucose level in patients with type 2 diabetes (T2DM) .Methods Totally 784 T2DM patients and 197 healthy controls were enrolled in this study.Age,duration,body mass index (BMI) ,systolic blood pressure (SBP) ,diastolic blood pressure (DBP) ,levels of fasting blood glucose (FBG) ,postprandial blood glucose (PBG) ,hemoglobin A1c (HbA1c) ,total cholesterol (TC) ,triglyceride (TG) ,

  5. Relationship between Para Clinical Findings of First Seizure and One Year Recurrence Rate in Children Admitted at Shaheed Sadoughi Hospital-Yazd

    Directory of Open Access Journals (Sweden)

    N Owaisi

    2007-12-01

    Full Text Available Introduction: Seizure is the most common pediatric neurology problem that occurs in 10% of children. The purpose of this study was to determine the recurrence rate of seizures after one year and its relationship with paraclinical findings of the first attack. Methods : In a historical cohort analytic study , 131 children with first seizure admitted to Shaheed Sadoughi Hospital between March 2004 to August 2005 were evaluated for recurrence rate during one year and its relationship with serum levels of sodium, potassium , glucose, calcium , Hb , MCV and PMN during the first attack. Results: 79.4% of cases were in febrile seizure group and 20.6% in first unprovoked seizure group (FUS.Of the total, 27.84 % of patients had seizure recurrence ( 27.9% in febrile and 25.9% in afebrile group. Mean survival recurrence rate was 10.11±0.32 SD months (10.25±0.33 SD months in febrile group and 9.57±0.83 SD months in FUS. Survival analysis showed that seizures recurred later in older patients. Younger age and lower Hb levels in the febrile seizure group and lower MCV in the FUS group were associated with an increased risk of recurrence. Conclusion: In this study, anemia and microcytic RBC were risk factors for seizure recurrence. Therefore, more studies should be done so as to decrease seizure recurrence by treating and preventing anemia.

  6. 上海市护理人员情绪智力与工作绩效相关性研究%Study on the Relationship between Clinical Nursing Staff' Emotional Intelligence and Their Job Performances in Shanghai

    Institute of Scientific and Technical Information of China (English)

    周海燕; 江有琴

    2012-01-01

    目的 了解上海市护理人员情绪智力水平和工作绩效现状,探讨两者之间的关系.方法 采用问卷调查法,随机抽取上海市两家三级综合性医院和一家二级综合性医院共260名临床一线护理人员进行调查.结果 护理人员整体情绪智力水平呈中等偏上程度(3.63±0.37),护理人员工作绩效的自评得分略高于护士长的他评,但其差异没有统计学意义(P>0.05),情绪智力与工作绩效各维度呈正相关(P<0.05).结论 护理人员情绪智力水平的提高可促进护理工作绩效.%Objectives To investigate the nurses'emotional intelligence and job performances, and analyze the relationships between them. Methods Total 260 clinical nurses in two level - three hospitals and one level -two hospital in shanghai were surveyed with questionnaires about the relationships between the nurses'emotional intelligence and job performances. Results It were showed that nurses'emotional intelligence was in the middle lev-el(3.63 ±0. 37) , and there was no significant difference between the scores of self - rating and other - rating of performance(P >0.05). There was a positive relationship between the nurses'emotional intelligence and job performance(P <0. 05). Conclusion The improvement of emotional intelligence can promote job performance of the clinical nurs

  7. RELATIONSHIP OF THE STAFF LOYALTY AND THE PERFORMANCE OF THE DENTAL CLINIC OF THE KRASNOYARSK STATE MEDICAL UNIVERSITY NAMED AFTER V.F. VOYNO-YASENETSKY

    OpenAIRE

    Татьяна Леонидовна Маругина; Анатолий Кузьмич Яркин; Вадим Валентинович Федотов; Екатерина Сергеевна Загородних

    2013-01-01

    We used the NPS methodology (Net Promoter Score) developed by Fred Reichheld to determine loyalty of KRASSMU dental clinic staff. The method makes it possible using only 2 questions to evaluate not only the level of employees’ loyalty to the organization, but also to identify the approaches of increasing or retaining this level.The doctors, nurses, administrative and general service staff - all in all 60 employees were involved in the survey. As a result of the survey the level of NPS of the ...

  8. Relationship between clinical nurse′s psychological capital and caring ability%临床护士心理资本与关爱能力的关系分析

    Institute of Scientific and Technical Information of China (English)

    朱亚芹

    2015-01-01

    Objective To investigate the clinical nurse′s psychological capital and caring ability, and analyze their relationship between them. Methods The psychological capital questionnaire ( PCQ) and caring ability rating form ( CAI ) were used to investigate 268 clinical nurses, and the relationship was analyzed between psychological capital and caring ability. Results The total score of PCQ was (81. 44 ± 14. 13) and total score of CAI was (191. 21 ± 20. 48);the psychological capital was positive correlated with caring ability ( r=0.295-0.438,P< 0. 01). Conclusions The psychological capital and caring ability are low in clinical nurses, so nursing managers should focus on nurse′s psychological capital so as to enhance nurse′s caring ability.%目的:调查临床护士心理资本与关爱能力状况,分析两者的关系。方法采用心理资本问卷( PCQ)和关爱能力评价表( CAI)对268名临床护士进行问卷调查,对护士心理资本与关爱能力的关系进行分析。结果护士PCQ总分为(81.44±14.13)分,CAI总分为(191.21±20.48)分,心理资本与关爱能力呈正相关(r值为0.295~0.438,P<0.01)。结论临床护士心理资本水平和关爱能力较低,护理管理者应关注护士心理资本,采取多种措施提升其心理资本,以便提高其护理关爱能力。

  9. Foot posture, leg length discrepancy and low back pain--their relationship and clinical management using foot orthoses--an overview.

    Science.gov (United States)

    Kendall, Julie C; Bird, Adam R; Azari, Michael F

    2014-06-01

    Mechanical low back pain (LBP) is a very common, expensive, and significant health issue in the western world. Functional musculoskeletal conditions are widely thought to cause mechanical low back pain. The role of foot posture and leg length discrepancy in contributing to abnormal biomechanics of the lumbopelvic region and low back pain is not sufficiently investigated. This critical review examines the evidence for the association between foot function, particularly pronation, and mechanical LBP. It also explores the evidence for a role for foot orthoses in the treatment of this condition. There is a body of evidence to support the notion that foot posture, particularly hyperpronation, is associated with mechanical low back pain. Mechanisms that have been put forward to account for this finding are based on either mechanical postural changes or alterations in muscular activity in the lumbar and pelvic muscles. More research is needed to explore and quantify the effects of foot orthoses on chronic low back pain, especially their effects on lumbopelvic muscle function and posture. The clinical implications of this work are significant since foot orthoses represent a simple and potentially effective therapeutic measure for a clinical condition of high personal and social burden.

  10. Relationship of the area measurement of the large endolymphatic duct and sac syndrome as well as the clinical symptoms with CT and MR imaging results

    Energy Technology Data Exchange (ETDEWEB)

    Park, Ji Sang; Hong, Hyun Sook; Lee, Jong Sea; Kim, Dae Ho; Lee, Hae Kyung; Yi, Beom Ha; Cha, Jang Gyu; Park, Seong Jin; Kim, Shi Chan [Soonchunhyang University Bucheon Hospital, Bucheon (Korea, Republic of)

    2008-08-15

    To evaluate the CT and MRI findings of the large endolymphatic duct or sac syndrome (LEDS) and its associated anomalies, with clinical features. We retrospectively reviewed the MR and CT images of 52 ears obtained from 26 patients with LEDS. We reviewed the clinical findings, audiology testing, and treatment results. The degree of hearing loss was classified from normal to profound, based on pure tone audiometry. The largest areas were measured at each endolymphatic duct and analyzed to determine whether a correlation exists with the degree of hearing loss. We also analyzed the differences in measurements between CT and MRI findings. All 26 patients had some degree of sensorineural hearing loss, which resulted in 18 ears to undergo a cochlear implantation. One patient was diagnosed with Cornelia de Lange syndrome. Five patients had a sudden hearing loss onset. Ten ears had incomplete cochlear partitions, whereas 28 ears had enlarged vestibules. All patients had severe to profound hearing loss. We found no statistical correlation between the size of the largest area of the endolymphatic duct and the degree of hearing loss. The mean area of the endolymphatic ducts, as per an MRI examination, revealed slightly greater areas than the CT findings, although the differences were not significant. Enlarged vestibules and incomplete partitions of the cochlea were common anomalies associated with LEDS. We found no statistical correlation between the largest area of the endolymphatic duct or sac with the degree of hearing loss.

  11. The ACVD task force on canine atopic dermatitis (XII): the relationship of cutaneous infections to the pathogenesis and clinical course of canine atopic dermatitis.

    Science.gov (United States)

    DeBoer, D J; Marsella, R

    2001-09-20

    Dogs and human beings with atopic dermatitis (AD) frequently exhibit concurrent skin infections with Staphylococcus sp. bacteria or Malassezia yeast, and treatment of such infections is an important facet of managing these patients. Staphylococci appear to colonize atopic skin readily, and bacterial products on the skin could augment cutaneous inflammation via immediate hypersensitivity responses to the bacteria, by superantigen-mediated lymphocyte activation, or other non-specific mechanisms. Similarly, skin colonization by Malassezia yeast could contribute to clinical signs of AD; yeast components could induce inflammation via non-specific mechanisms, such as alteration in mediator release, or via antigen-specific hypersensitivity reactions. Clinical and experimental evidence exists that secondary microbial infections can both initiate and perpetuate episodes of AD in dogs and humans, and could even participate in promotion of pro-allergic immunologic responses. Mechanistic details of these complex interactions are under extensive investigation in human beings; only a few observations have been extended to include dog with AD. PMID:11553386

  12. Relationship of the area measurement of the large endolymphatic duct and sac syndrome as well as the clinical symptoms with CT and MR imaging results

    International Nuclear Information System (INIS)

    To evaluate the CT and MRI findings of the large endolymphatic duct or sac syndrome (LEDS) and its associated anomalies, with clinical features. We retrospectively reviewed the MR and CT images of 52 ears obtained from 26 patients with LEDS. We reviewed the clinical findings, audiology testing, and treatment results. The degree of hearing loss was classified from normal to profound, based on pure tone audiometry. The largest areas were measured at each endolymphatic duct and analyzed to determine whether a correlation exists with the degree of hearing loss. We also analyzed the differences in measurements between CT and MRI findings. All 26 patients had some degree of sensorineural hearing loss, which resulted in 18 ears to undergo a cochlear implantation. One patient was diagnosed with Cornelia de Lange syndrome. Five patients had a sudden hearing loss onset. Ten ears had incomplete cochlear partitions, whereas 28 ears had enlarged vestibules. All patients had severe to profound hearing loss. We found no statistical correlation between the size of the largest area of the endolymphatic duct and the degree of hearing loss. The mean area of the endolymphatic ducts, as per an MRI examination, revealed slightly greater areas than the CT findings, although the differences were not significant. Enlarged vestibules and incomplete partitions of the cochlea were common anomalies associated with LEDS. We found no statistical correlation between the largest area of the endolymphatic duct or sac with the degree of hearing loss

  13. Relationship of circulating cell-free DNA levels to cell-free fetal DNA levels, clinical characteristics and laboratory parameters in preeclampsia

    Directory of Open Access Journals (Sweden)

    Mézes Miklós

    2009-01-01

    Full Text Available Abstract Background The aim of our study was to examine whether increased circulating total cell-free DNA levels are related to the clinical characteristics and standard laboratory parameters of preeclamptic patients, to markers of inflammation, endothelial activation or injury, oxidative stress and to cell-free fetal DNA levels. Methods Circulating total cell-free DNA was measured by real-time quantitative PCR in plasma samples obtained from 67 preeclamptic and 70 normotensive pregnant women. Standard laboratory parameters, C-reactive protein, plasma von Willebrand factor antigen, plasma fibronectin, plasma malondialdehyde and cell-free fetal DNA levels were also determined. Results and Conclusion Circulating total cell-free and fetal deoxyribonucleic acid levels were significantly elevated in pregnancies complicated by preeclampsia (median: 11.395 vs. 32.460 and 0.001 vs. 0.086 pg/μl; P < .001. The quantity of plasma total cell-free DNA did not correlate with most of the laboratory parameters, except for serum aspartate aminotransferase and alanine aminotransferase activities (correlation coefficient: 0.31; P = 0.012 and 0.46; P < .001. There was no correlation with clinical characteristics, including body mass index. The releases of both free fetal and total cell-free deoxyribonucleic acid were found to be affected in preeclampsia. Hepatocellular necrosis seems to be responsible - at least partly - for increased circulating total DNA levels in preeclampsia, as suggested by the significant correlation with liver enzyme activities.

  14. Clinical value of periventricular low-intensity areas detected by fluid attenuated inversion recovery (FLAIR). Relationships between perinatal vital parameter and neonatal MRI

    International Nuclear Information System (INIS)

    A follow-up study was performed to assess the correlation among the incidence of periventricular low intensities (PVLI) on MRI (magnetic resonance imaging) FLAIR (fluid attenuated inversion recovery) imaging, clinical evidence of perinatal insults that may cause white matter damage, and the outcome of the infants. We evaluated periventricular white matter lesions of 329 neonates whose MRI were obtained before two months corrected age. The detective rate of periventricular abnormalities on FLAIR imaging was significantly higher than that of T1-T2 weighted imaging. The most typical lesion detected on FLAIR imaging was periventricular low intensities (PVLI), frequently observed in the neonates with a history of preterm labour, very low birth weight, birth asphyxia and severe respiratory failure. Although we could not characterize the risk factors of PVLI, the incidence of PVLI had a strong correlation with the scores of motor and developmental tests at 12 and 36-months corrected age. In conclusion, FLAIR imaging, detecting the border zone damage of white matter, would be a strong tool to pick out neonates at high risk of neurological disturbances from those without clinical evidence of neurological insults in the neonatal period. (author)

  15. Relationship between career adaptability and clinical communication behavior of undergraduate nursing students%本科实习护生生涯适应力与临床沟通行为的关系

    Institute of Scientific and Technical Information of China (English)

    胡清媛; 孔祥静; 李亚兰; 李健

    2015-01-01

    Objective:To probe into the relationship between career adaptability and clinical communication be-havior of undergraduate nursing students,so as to provide references for improving the clinical communication ability of nursing students.Methods:A total of 552 undergraduate nursing students were assessed by using Chi-nese version of career adaptability and clinical communication skills assessment scale,and to analyze the rela-tionship between the both.Results:The score of career adaptability of undergraduate nursing interns was 3.30± 0.37,the score of clinical communication behavior was 2.63±0.35;the career adaptability was positively corre-lated with clinical communication behaviors;3 dimensions of career concern,career control,and career confidence in career adaptability can predict 28.7%clinical communication behavior.Conclusion:The career adaptability of undergraduate nursing interns were at middle partial level,the overall clinical communication ability was better but needed to further improved.The career adaptability can effectively predict the clinical communication be-havior of undergraduate nursing interns.Nursing managers and educators should further cultivate the career a-daptability of undergraduate nursing interns in order to improve the clinical communication ability.%[目的]探讨本科实习护生生涯适应力与临床沟通行为的关系,为提高本科实习护生的临床沟通能力提供参考。[方法]对552名本科实习护生运用中文版生涯适应力量表和临床沟通能力测评量表进行测试,分析二者的关系。[结果]本科实习护生生涯适应力得分3.30分±0.37分,临床沟通行为得分2.63分±0.35分;生涯适应力与临床沟通行为呈正相关;生涯适应力中生涯关注、生涯控制、生涯自信3个维度能预测临床沟通行为的28.7%。[结论]本科实习护生生涯适应力处于中等偏上水平,临床沟通能力总体较好但需要进一步改善,生涯适应力

  16. Clinical value of periventricular low-intensity areas detected by fluid attenuated inversion recovery (FLAIR). Relationships between MRI at near term and long-distant outcome

    Energy Technology Data Exchange (ETDEWEB)

    Iwata, Osuke; Kadowaki, Sachiko; Tamura, Masanori [Nagano Children' s Hospital, Toyoshina (Japan)] (and others)

    2002-01-01

    We performed an MRI (magnetic resonance imaging) study of neonatal brain to assess the clinical value of periventricular low intensities (PVLI) detected on FLAIR (fluid attenuated inversion recovery) imaging in 280 preterm and term infants. The incidence of PVLI was 62% on early MRI, obtained before two-months corrected age, and it decreased to 3% and 0% on middle (2-8 months) and late (8-18 months) MRI. On middle and late MRI, we observed periventricular hyperintensities (PVHI) both on FLAIR imaging and T2-weighted imaging, which were considered to be chronic lesions of leukomalacia. The severity of white matter damage diagnosed on early FLAIR imaging had a significant correlation with that of late FLAIR imaging. We conclude that early FLAIR imaging would be a good predictor of chronic white matter damage that may influence the motor and mental development of the infants. (author)

  17. 白癜风光疗疗效与临床的关系%Relationship between the efficacy of phototherapy and clinical factors in patients with vitiligo

    Institute of Scientific and Technical Information of China (English)

    邱实; 许爱娥

    2013-01-01

    白癜风是一种色素脱失性疾病,以皮肤或黏膜色素减退为特征,多为后天发病,可见于任何年龄,以青壮年多见,部分患者有明显的季节性,一般春末夏初病情加重,冬季缓解.任何部位均可发病,但好发于暴露部位.该病治疗困难,影响美观,给患者带来精神心理压力.目前运用较广泛的有308 nm准分子激光、窄谱中波紫外线和氦氖激光等,临床应用发现,光疗的疗效与白癜风分型、部位、病程、治疗次数、皮肤类型和红斑反应等相关.%Vitiligo is a pigmentary disorder characterized by cutaneous or mucous hypopigmentation.It is usually acquired,and may occur at any age,but is more common in young adults.In some patients with vitiligo,the condition gets worse at late spring and early summer,but better in winter.It may affect any body sites with a predilection for exposed sites.Vitiligo can bring psychical and mental stress to patients by affecting their appearance,however,it still remains difficult to treat.At present,commonly used phototherapy for vitiligo includes 308-nm excimer laser,narrow band-ultraviolet B,helium neon laser,etc.Clinical practice has suggested that the efficacy of phototherapy is associated with the type,site,clinical course of vitiligo,as well as treatment sessions,skin types and erythema reaction of patients.

  18. Clinical significance of miR-140-5p and miR-193b expression in patients with breast cancer and relationship to IGFBP5

    Directory of Open Access Journals (Sweden)

    Gökçe Güllü

    2015-03-01

    Full Text Available The functional role of IGFBP5 in breast cancer is complicated. Experimental and bioinformatics studies have shown that IGFBP5 is targeted by miR-140-5p and miR-193b, although this has not yet been proven in clinical samples. The aim of this study was to evaluate the expression of miR-140-5p and miR-193b in breast cancer and adjacent normal tissue and assess its correlation with IGFBP5 and the clinicopathological characteristics of the tumors. IGFBP5 protein expression was analyzed immunohistochemically and IGFBP5, miR-140 and miR-193b mRNA expression levels were analyzed with real-time RT-PCR. Tumor tissue had higher miR-140-5p expression than adjacent normal tissue (p = 0.015. Samples with no immunohistochemical staining for IGFBP5 showed increased miR-140-5p expression (p = 0.009. miR-140-5p expression was elevated in invasive ductal carcinomas (p = 0.002, whereas basal-like tumors had decreased expression of miR-140-5p compared to other tumors (p = 0.008. Lymph node-positive samples showed an approximately 13-fold increase in miR-140-5p expression compared to lymph node-negative tissue (p = 0.049. These findings suggest that miR-140-5p, but not miR-193b, could be an important determinant of IGFBP5 expression and clinical phenotype in breast cancer patients. Further studies are needed to clarify the expressional regulation of IGFBP5 by miR-140-5p.

  19. Relationship of Epstein-Barr virus and interleukin 10 promoter polymorphisms with the risk and clinical outcome of childhood Burkitt lymphoma.

    Directory of Open Access Journals (Sweden)

    Carolina Minnicelli

    Full Text Available Epstein-Barr virus (EBV is an important environmental factor associated to the development of Burkitt lymphoma (BL in endemic and intermediate risk regions. However, little is known about the contribution of genetic constitution to the development and clinical response of the disease. The aim of this work was to investigate the role of EBV and Interleukin 10 (IL10 single nucleotide polymorphisms (-1082A/G, -819C/T, -592C/A and microsatellites (IL10.R and IL10.G in susceptibility and clinical outcome in pediatric BL patients, in a region with intermediate EBV association frequency. The frequencies of IL10 promoter Single nucleotide polymorphisms -1082A/G, -819C/T, -592C/A, and IL10.R and IL10.G microsatellites were compared in 62 pediatric patients and 216 healthy donors. IL10 -1082GG and GCC/GCC genotypes were more frequent in patients than in controls, and associated to a higher risk of BL development (GG genotype OR 2.62, 95% CI, 1.25-5.51; P = 0.008; Pc = 0.024. EBV was detected in tumor samples by EBER-ISH in 54.1% of cases. EBV+ patients exhibited a better event free survival (EFS (P = 0.019 than EBV- patients. Carriers of IL10 R3-GCC had worse EFS (P = 0.028. Our results suggest a risk effect and an independent prognostic value of IL10 polymorphisms and EBV in childhood BL patients.

  20. Relationship between innate immunity, soluble markers and metabolic-clinical parameters in HIV+ patients ART treated with HIV-RNA<50 cp/mL

    Directory of Open Access Journals (Sweden)

    Chiara Dentone

    2014-11-01

    Full Text Available Introduction: The persistence of immune activation and inflammation in HIV patients with HIV-RNA (VL undetectable causes many co-morbidities [1–3]. The aim of this study is to correlate monocytes (m and NK cell activation levels, soluble markers and oxidative stress with clinical, biochemical and metabolic data in HIV-1 infected patients with VL≤50 copies (cp/mL on antiretroviral therapy. Materials and Methods: Multicentre, cross-sectional study in patients with VL≤50 cp/mL and on antiretroviral therapy by at least six months. We studied: activation/homing markers (CD38, HLA-DR, CCR-2, PDL-1 on inflammatory, intermediate, proinflammatory m; activatory receptors NKp30, NKp46 and HLA-DR on NK cells; soluble inflammatory (sCD14, adiponectina, MCP-1 and stress oxidative markers (dRoms, antiRoms. Univariate analyses are performed with non-parametric and Pearson tests. The significant correlations were adjusted for possible known confounding factors (smoking, Cytomegalovirus IgG serology, Raltegravir, Protease Inhibitor [PI] therapy and HCV-RNA with multivariate analysis. Results: In the 68 patients the positive correlation between age and antiRoms was significant also after adjustment for PI use (p=0.05. The% CD8+T was associated with% proinflammatory m (p=0.043 and with their expression of CCR2 mean fluorescence intensity (MFI (p=0.012. The% NKp46+ was positively correlated with CD4+T count (p=0.001. The fibrinogen was positively associated with dRoms (p=0.052 and the positive correlation between triglycerides and antiRoms has been confirmed (p<0.001; the impact of antiRoms on HDL/triglycerides ratio (p=0.006 was observed after adjustment for PI use. The BMI was associated with smoking (p=0.011. Only the maraviroc-treated patients showed minimal arterial pressure, fibrinogen and antiRoms lower (p=0.001, 0.004 e 0.006 and sCD14 values higher (p=0.029. Conclusions: Patients with long history of HIV infection and stable immunological and

  1. Prevalence and clinical impact of sensitization to latex and fruits in dentistry students at the University of Antioquia, and its relationship with allergy to fruits

    Directory of Open Access Journals (Sweden)

    Echenique Manrique, Alejandro

    2015-04-01

    Full Text Available Objective: To determine the prevalence and clinical impact of sensitization to latex and to five tropical fruits (banana, avocado, kiwi, pineapple and passion fruit in dentistry students. Methods: Analytical cross-sectional study of 128 dentistry students at University of Antioquia in Medellín, Colombia. Information was collected by means of a questionnaire and skin prick tests with latex and fruits were done. Results: All students reported having had contact with latex. Nine of them informed at least one episode of adverse reaction to contact with latex without proof of sensitization to it. Five reported at least one reaction with one of the fruits, but skin prick tests were negative. Four of the 14 students who reported gastrointestinal symptoms were sensitized to latex or to one of the tested fruits. Overall, latex sensitization rate was 3.1%. Conclusion: This percentage of sensitization to latex is lower than that in other studies; this may be due to the expression of immune mechanisms other than IgE mediation. We failed to demonstrate a higher sensitization rate to latex as students advanced in their career. The association between gastrointestinal symptoms and sensitization to both fruit and latex is to be emphasized.

  2. Frequent Promoter Methylation of CDH1, DAPK, RARB, and HIC1 Genes in Carcinoma of Cervix Uteri: Its Relationship to Clinical Outcome

    Directory of Open Access Journals (Sweden)

    Schneider Achim

    2003-05-01

    Full Text Available Abstract Background Cervical cancer (CC, a leading cause of cancer-related deaths in women worldwide, has been causally linked to genital human papillomavirus (HPV infection. Although a host of genetic alterations have been identified, molecular basis of CC development is still poorly understood. Results We examined the role of promoter hypermethylation, an epigenetic alteration that is associated with the silencing tumor suppressor genes in human cancer, by studying 16 gene promoters in 90 CC cases. We found a high frequency of promoter methylation in CDH1, DAPK, RARB, and HIC1 genes. Correlation of promoter methylation with clinical characteristics and other genetic changes revealed the following: a overall promoter methylation was higher in more advanced stage of the disease, b promoter methylation of RARB and BRCA1 predicted worse prognosis, and c the HIC1 promoter methylation was frequently seen in association with microsatellite instability. Promoter methylation was associated with gene silencing in CC cell lines. Treatment with methylation or histone deacetylation-inhibiting agents resulted in profound reactivation of gene expression. Conclusions These results may have implications in understanding the underlying epigenetic mechanisms in CC development, provide prognostic indicators, and identify important gene targets for treatment.

  3. TH与乳腺疼痛的相关临床研究%Clinical study on relationship between thyroid gland related hormone and hyperplasia of mammary gland

    Institute of Scientific and Technical Information of China (English)

    徐虓; 刘志英; 孙祝生; 刘会岭

    2015-01-01

    Objective: To study the correlation between thyroid hormone levels and breast pain rating, mammary gland thickness, and gland hyperplasia degree. Methods: From January 2010 to June 2013, 130 patients with breast pain as the chief complaint to the hospital were randomly selected. Correlation between breast pain rating, mammary gland thickness, gland hyperplasia degree and thyroid stimulating hormone (TSH), triiodothyronine (T3), tetraiodothyronine (T4), thyroid peroxidase antibodies (TPO), thyroglobulin antibody (TG), TSH receptor antibody (Anti-TSHR), mammary gland disorder, and thyroid disease were analyzed. Results: Degree of breast hyperplasia is unrelated with serum T3, T4, TPO, TG, Anti-TSHR level (P>0.05), and it is related with serum TSH levels (P=0.002, P0.05). There is no significant relationship between mammary gland hyperplasia degree and the gland structural disorder (P>0.05), while the correlation of mammary gland hyperplasia degree with presence of thyroid disease is significant. Patients with thyroid disease are apt to have severer mammary gland hyperplasia (P0.05),与血清TSH水平相关(P=0.002,P0.05).乳腺增生程度与乳腺腺体结构紊乱之间无明显关系(P>0.05),与是否有甲状腺疾患有关,有甲状腺疾患者乳腺增生程度较重(P<0.05).结论:血清TSH升高可引起乳腺增生,乳腺疼痛程度与甲状腺相关激素水平无关.中重度乳腺增生患者往往合并甲状腺疾患.

  4. Clinical relationship of myocardial sympathetic nervous activity to cardiovascular functions in chronic heart failure: assessment by myocardial scintigraphy with 123I-metaiodobenzylguanidine.

    Science.gov (United States)

    Wada, Yukoh; Miura, Masaetsu; Fujiwara, Satomi; Mori, Shunpei; Seiji, Kazumasa; Kimura, Tokihisa

    2003-12-01

    The aim of this study was to clarify the relationship between cardiac sympathetic nervous activity (SNA) assessed by radioiodinated metaiodobenzylguanidine (123I-MIBG), an analogue of norepinephrine and cardiovascular functions in patients with chronic heart failure (CHF). Subjects were 17 patients with CHF. A dose of 111 MBq of 123I-MIBG was administered intravenously, and 5-minute anterior planar images were obtained 15 minutes (early image) and 3 hours (delayed image) after the injection. The heart/mediastinum (H/M) count ratio was defined to quantify cardiac 123I-MIBG uptake. The washout ratio (WR) of 123I-MIBG from the heart was calculated as follows: (early counts-delayed counts)/early counts x 100 (%). Echocardiography was performed on all patients within 1 week of 123I-MIBG scintigraphy to measure stroke volume index (SVI). Blood pressure and heart rate (HR) in the resting state were also recorded to calculate cardiovascular functions including cardiac output, pulse pressure (PP), and mean blood pressure. Significant linear correlations were found between the early H/M ratio of 123I-MIBG and SVI, and between the delayed H/M ratio of 123I-MIBG and SVI, respectively. WR of 123I-MIBG was correlated with HR, and was inversely correlated with SVI and with PP, respectively. It is likely that a decrease in SVI is associated with enhanced cardiac SNA in severe CHF. 123I-MIBG scintigraphy is effective in assessing the cardiac functional status and SNA in patients with CHF in vivo. Moreover, changes in PP and HR indicate well alteration in SNA. PMID:14690018

  5. The relationship between microfilaraemic and amicrofilaraemic loiasis involving co-infection with Mansonella perstans and clinical symptoms in an exposed population from Gabon.

    Science.gov (United States)

    Bouyou Akotet, M K; Owono-Medang, M; Mawili-Mboumba, D P; Moussavou-Boussougou, M N; Nzenze Afène, S; Kendjo, E; Kombila, M

    2016-07-01

    The relationship between the frequency of loiasis objective symptoms and microfilaraemic or amicrofilaraemic infection was assessed in 1148 exposed patients also infected, or not, with Mansonella perstans. Filarial infections were detected by direct microscopy, leucoconcentration and serology, with prevalence values of 39.5% Loa loa, 5.6% M. perstans and 3.4% co-infection with both filarial species. Amicrofilaraemic or occult loiasis (OL) predominated among L. loa-infected individuals, with a prevalence of 58.2%. Hypermicrofilaraemia (>8000 microfilariae (mf)/ml) was found in 18.4% of L. loa microfilaraemic patients, with 25.7% of them harbouring more than 30,000 mf/ml. Up to 34% of patients with OL showed evidence of Calabar swelling, compared with 26.3% of microfilaraemic patients (P= 0.03). Overall 5.3% of patients presented with adult worm migration across the eye, representing 16.3% of microfilaraemic individuals and 11.4% of amicrofilaraemic patients (P= 0.13). This symptom was similarly found in patients with more than 30,000 mf/ml (22%), those with microfilaraemia between 8 and 30,000 mf/ml (15.4%) and also in individuals with low or without microfilaraemia (16.1%) (P= 0.7). Five (14.3%) hypermicrofilaraemic patients did not present any L. loa-specific objective symptoms, as well as all the patients with single M. perstans infection. The presence of adult eye worm migration as a strong predictor of high microfilaraemia density would obscure the real burden of L. loa hypermicrofilaraemia in exposed individuals. For epidemiological purposes and control strategies, the mapping of L. loa in endemic areas should also take into account the group of patients with occult loiasis. PMID:26268068

  6. Molecular sources of residual cardiovascular risk, clinical signals, and innovative solutions: relationship with subclinical disease, undertreatment, and poor adherence: implications of new evidence upon optimizing cardiovascular patient outcomes

    Directory of Open Access Journals (Sweden)

    Kones R

    2013-10-01

    would be cardioprotective. When LDL cholesterol is aggressively lowered to targets, low HDL cholesterol levels are still inversely related to MCVE. The efflux capacity, or ability to relocate cholesterol out of macrophages, is believed to be a major antiatherogenic mechanism responsible for reduction in MCVE mediated in part by healthy HDL. HDL cholesterol is a complex molecule with antioxidative, anti-inflammatory, antithrombotic, antiplatelet, and vasodilatory properties, among which is protection of LDL from oxidation. HDL-associated paraoxonase-1 has a major effect on endothelial function. Further, HDL promotes endothelial repair and progenitor cell health, and supports production of nitric oxide. HDL from patients with cardiovascular disease, diabetes, and autoimmune disease may fail to protect or even become proinflammatory or pro-oxidant. Mendelian randomization and other clinical studies in which raising HDL cholesterol has not been beneficial suggest that high plasma levels do not necessarily reduce cardiovascular risk. These data, coupled with extensive preclinical information about the functional heterogeneity of HDL, challenge the “HDL hypothesis”, ie, raising HDL cholesterol per se will reduce MCVE. After the equivocal AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health Outcomes study and withdrawal of two major cholesteryl ester transfer protein compounds, one for off-target adverse effects and the other for lack of efficacy, development continues for two other agents, ie, anacetrapib and evacetrapib, both of which lower LDL cholesterol substantially. The negative but controversial HPS2-THRIVE (the Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events trial casts further doubt on the HDL cholesterol hypothesis. The growing impression that HDL functionality, rather than abundance, is clinically important is supported by experimental evidence highlighting

  7. Modelling PK/QT relationships from Phase I dose-escalation trials for drug combinations and developing quantitative risk assessments of clinically relevant QT prolongations.

    Science.gov (United States)

    Sinclair, Karen; Kinable, Els; Grosch, Kai; Wang, Jixian

    2016-05-01

    In current industry practice, it is difficult to assess QT effects at potential therapeutic doses based on Phase I dose-escalation trials in oncology due to data scarcity, particularly in combinations trials. In this paper, we propose to use dose-concentration and concentration-QT models jointly to model the exposures and effects of multiple drugs in combination. The fitted models then can be used to make early predictions for QT prolongation to aid choosing recommended dose combinations for further investigation. The models consider potential correlation between concentrations of test drugs and potential drug-drug interactions at PK and QT levels. In addition, this approach allows for the assessment of the probability of QT prolongation exceeding given thresholds of clinical significance. The performance of this approach was examined via simulation under practical scenarios for dose-escalation trials for a combination of two drugs. The simulation results show that invaluable information of QT effects at therapeutic dose combinations can be gained by the proposed approaches. Early detection of dose combinations with substantial QT prolongation is evaluated effectively through the CIs of the predicted peak QT prolongation at each dose combination. Furthermore, the probability of QT prolongation exceeding a certain threshold is also computed to support early detection of safety signals while accounting for uncertainty associated with data from Phase I studies. While the prediction of QT effects is sensitive to the dose escalation process, the sensitivity and limited sample size should be considered when providing support to the decision-making process for further developing certain dose combinations. Copyright © 2016 John Wiley & Sons, Ltd. PMID:26991506

  8. Measuring the extent of total thyroidectomy for differentiated thyroid carcinoma using radioactive iodine imaging: relationship with serum thyroglobulin and clinical outcomes.

    Science.gov (United States)

    Holsinger, F Christopher; Ramaswamy, Uma; Cabanillas, Maria E; Lang, Juntian; Lin, Heather Y; Busaidy, Naifa L; Grubbs, Elizabeth; Rahim, Sania; Sturgis, Erich M; Lee, Jeffrey E; Weber, Randal S; Clayman, Gary L; Rohren, Eric M

    2014-05-01

    IMPORTANCE Despite performing total thyroidectomy (TT), postoperative radioactive iodine (RAI) imaging often demonstrates the presence of residual thyroid tissue within the operative bed. OBJECTIVE To measure the extent of TT using postoperative RAI imaging and assessing serum thyroglobulin (Tg) level for patients with differentiated thyroid carcinoma (DTC). DESIGN, SETTING, AND PARTICIPANTS We evaluated 245 patients undergoing TT for clinically staged cT1-3N0M0 DTC, who underwent diagnostic postoperative RAI imaging. INTERVENTIONS Total thyroidectomy. MAIN OUTCOMES AND MEASURES On the basis of quantitative measurements, RAI uptake (RAIU) in the thyroid bed of 0.2% of administered activity was selected as the cutpoint to determine the presence or absence of thyroid remnant. RESULTS By postoperative RAI imaging, TT in 106 patients (43%) resulted in RAIU of less than 0.2%. In the remaining 139 patients (57%), there was measurable iodine-avid thyroid tissue and/or tumor in the thyroid bed (n = 117 [84%]), the neck (n = 4 [3%]), or both (n = 18 [13%]). For the entire study population, mean 24-hour RAIU was 0.62%. Stimulated serum Tg levels were obtained in 232 of 245 patients (95%). Measurable stimulated Tg level (≥1 ng/mL) (to convert to micrograms per liter, multiply by 1) was found in 26 of 102 patients (25%) without thyroid remnant and in 87of 133 patients (65%) with thyroid remnant (P < .001). CONCLUSIONS AND RELEVANCE A goal of postthyroidectomy RAIU of less than 0.2% helps maximize the likelihood of an unmeasurable postoperative Tg level, potentially simplifying follow-up evaluation and reducing the use of postoperative RAI in order to facilitate surveillance.

  9. EGFR Mutations in Surgically Resected Fresh Specimens from 697 Consecutive Chinese Patients with Non-Small Cell Lung Cancer and Their Relationships with Clinical Features

    Directory of Open Access Journals (Sweden)

    Yuanyang Lai

    2013-12-01

    Full Text Available We aimed to reveal the true status of epidermal growth factor receptor (EGFR mutations in Chinese patients with non-small cell lung cancer (NSCLC after lung resections. EGFR mutations of surgically resected fresh tumor samples from 697 Chinese NSCLC patients were analyzed by Amplification Refractory Mutation System (ARMS. Correlations between EGFR mutation hotspots and clinical features were also explored. Of the 697 NSCLC patients, 235 (33.7% patients had tyrosine kinase inhibitor (TKIs sensitive EGFR mutations in 41 (14.5% of the 282 squamous carcinomas, 155 (52.9% of the 293 adenocarcinomas, 34 (39.5% of the 86 adenosquamous carcinomas, one (9.1% of the 11 large-cell carcinomas, 2 (11.1% of the 18 sarcomatoid carcinomas, and 2 (28.6% of the 7 mucoepidermoid carcinomas. TKIs sensitive EGFR mutations were more frequently found in female patients (p < 0.001, non-smokers (p = 0.047 and adenocarcinomas (p < 0.001. The rates of exon 19 deletion mutation (19-del, exon 21 L858R point mutation (L858R, exon 21 L861Q point mutation (L861Q, exon 18 G719X point mutations (G719X, including G719C, G719S, G719A were 43.4%, 48.1%, 1.7% and 6.8%, respectively. Exon 20 T790M point mutation (T790M was detected in 3 squamous carcinomas and 3 adenocarcinomas and exon 20 insertion mutation (20-ins was detected in 2 patients with adenocarcinoma. Our results show the rates of EGFR mutations are higher in all types of NSCLC in Chinese patients. 19-del and L858R are two of the more frequent mutations. EGFR mutation detection should be performed as a routine postoperative examination in Chinese NSCLC patients.

  10. The relationship between psychological contract and the satisfaction of recruitment commitment among clinical nurses%临床护士心理契约与招聘承诺实现满意度关系的研究

    Institute of Scientific and Technical Information of China (English)

    刘晓丹; 吴世菊; 彭宇阁; 宫健美

    2011-01-01

    Objective: To explore the relationship between psychological contract and the satisfaction of recruitment commitment among clinical nurses, and to propose targeted recruitment programs from the perspective of psychological contract.Methods:Psychological Contract Questionnaire for nurses and Satisfaction of Recruitment Commitment Questionnaire for nurses were used to investigate and the results wereanalyzed by statistical methods.Results: There was a positive relationship (P <0.01)between the developmental and real responsibility of hospital and the satisfaction of recruitment commitment of nurses.Conclusion: The commitment of developmental and real responsibility of hospital should be improved.%目的:了解护士心理契约与护士的招聘承诺实现满意度之间的关系,从心理契约的角度提出针对性的护士招聘方案.方法:采用"护士心理契约调查问卷"及"护士招聘承诺实现满意度调查问卷"对护士进行调查,并对结果进行统计分析.结果:医院的发展责任及现实责任与护士的招聘承诺实现满意度呈正相关(P<0.01).结论:医院在现实责任及发展责任方面作出的承诺有待完善.

  11. 人际关系对大专护生实习效果影响的质性研究%Effect of interpersonal relationship on clinical practice outcome of associate degree nursing students: A qualitative study

    Institute of Scientific and Technical Information of China (English)

    徐然; 沈军

    2014-01-01

    目的 构建适用于大专护生的人际关系内涵的诠释理论.方法 采用扎根理论研究法对10名大专生进行深度访谈,经过三级编码和反复比较,确定大专生临床实习中的人际关系内涵.结果 本研究形成的人际关系内涵,核心概念为“获得归属感”,主要受到带教老师、护士长、患者及家属、本科实习生、医生的影响.结论 根据该诠释理论,可构建和谐的临床实习人际关系,提高实习效果.%Objective To construct interpretation theory which is suitable to explain the connotation of interpersonal relationship among associate degree nursing students.Methods The data were collected through deep interviews.The content of interpersonal relationship was affirmed by three-level coding and comparing repeatedly.Results The core concept was "gaining a feeling of belonging" and it could be affected by 5 generic concepts including clinical teachers,head nurses,baccalaureate degree nursing students,patients and doctors.Conclusions Harmonious interpersonal relationship can be built according to the theory of interpretation and practice outcomes can be improved.

  12. 临床护理人员情绪智力与工作绩效关系调查%Investigation on the relationship between emotional intelligence and job performance of clinical nursing staff

    Institute of Scientific and Technical Information of China (English)

    张磊; 孙晓晶; 刘堃; 张林

    2011-01-01

    [目的]了解护理人员情绪智力分布状况,探讨情绪智力与工作绩效的关系.[方法]对7所医院629名护理人员的情绪智力及工作绩效进行测量,探求情绪智力与工作绩效的关系.[结果]护理人员情绪智力整体水平较高;年龄、职称对护士情绪智力有一定影响;情绪智力4个维度与工作绩效关系密切;当情绪智力4维度全部进入回归模型时,能够解释总变异的27.6%.[结论]护理管理者应加强对临床护理人员情绪智力的培养,进一步提高工作绩效.%Objective:To know about the distribution status of emotional in telligence of nursing staffs and to probe into the relationship between emo tional intelligence and job performance. Methods: Emotional intelligence and job performance of 629 nursing staff from 7 hospitals were measured. Then the relationships between emotional intelligence and job performance were probed. Results:Emotional intelligence of nursing staff was at a high level. Age and professional title of nursing staff had some impacts on emotional in telligence. There were close relationships between four dimensions of emo tional intelligence and job performance. When all four dimensions of emotion al intelligence were considered into the regression model, emotional intelli gence could explain 27. 6% of the total variance. Conclusion:Nursing admin istrators should strengthen the cultivation of emotional intelligence of clinical nursing staff so as to enhance their job performance a step further.

  13. Osteoporotic compression fracture of the thoracolumbar spine and sacral insufficiency fracture: incidence and analysis of the relationship according to the clinical factors

    Energy Technology Data Exchange (ETDEWEB)

    Kong, Jeong Hwa; Park, Ji Sun; Ryu, Kyung Nam [Kyunghee University Hospital, Seoul (Korea, Republic of)

    2006-11-15

    To evaluate the incidence of sacral insufficiency fracture in osteoporotic patient with compression fracture of the thoracolumbar (T-L) spine on magnetic resonance image (MRI), and to analyze the correlation of variable clinical factors and the incidence of sacral insufficiency fracture. We retrospectively reviewed 160 patients (27 men, 133 women; age range of 50 to 89 years) who underwent spinal MRI and had compression fracture of the T-L spine. Compression fractures due to trauma or tumor were excluded. We evaluated the incidence of sacral insufficiency fracture according to the patients' age, sex, number of compression fractures, and the existence of bone marrow edema pattern of compression fracture. During the same period, we evaluated the incidence of spinal compression fracture in the patients of pelvic insufficiency fracture. Out of the 160 patients who had compression fracture in the T-L spine, 17 (10.6%) had insufficiency fracture of the sacrum. Compression fracture occurred almost 5 times more frequently in women (27:133), but the incidence of sacral insufficiency fracture was 2/27 for men (7.4%) and 15/133 for women (11.3%), with no statistically significant difference ({rho} = 0.80). According to age, the ratio of insufficiency fracture to compression fracture was 0% (0/23) in the 50's, 10.6% (7/66) in the 60's, 12.5% (7/56) in the 70's, and 20.0% (3/15) in the 80's. In respect of single and multiple compression fracture, the incidence of sacral insufficiency fracture was 8/65 for men (12.3%) and 9/95 for women (9.5%), showing no significant difference ({rho} = 0.37). In the patients with and without compression fracture with bone marrow edema, insufficiency fracture occurred in 5/76 (6.6%) and 12/84 (14.3%), respectively. On the other hand, of the 67 patients who had pelvic insufficiency fracture, 27 (40.3%) also had spinal compression fracture. About 10% of the patients with osteoporotic compression fracture in the T/L spine

  14. Relationship of the sexual functions with the clinical parameters, radiological scores and the quality of life in male patients with ankylosing spondylitis.

    Science.gov (United States)

    Sariyildiz, Mustafa Akif; Batmaz, Ibrahim; Dilek, Banu; Inanir, Ahmet; Bez, Yasin; Tahtasiz, Mehmet; Em, Serda; Cevik, Remzi

    2013-03-01

    with AS. This impairment in the sexual function is especially correlated with the BASFI and BASMI among the clinical and laboratory parameters.

  15. 护患关系对临床护士职业倦怠的影响%lnfluence of nurse-patient relationship on job burnout of clinical nurses

    Institute of Scientific and Technical Information of China (English)

    和树芸

    2015-01-01

    Objective:To explore the influence of nurse-patient relationship on job burnout of clinical nurses so as to put forward the corresponding countermeasures. Methods:450 clinical nurses were investigated by using the general questionnaire for nurses and the job burnout inventory ( MBI-HSS) . Results:The factors influencing the detection rate of job burnout of nurses were:the self-assessment of nurse′s worKing environment,the degree of patient′s trust and respect;the factors influencing the score of each dimension were:the self-assessment of nurse′s worKing environment,the degree of patient's trust and respect and the patient's satisfaction with nursing service ( P<0. 05);the higher the scores were,the heavier the degree of job burnout was (P<0. 05). Conclusion:The nurse-patient relationship is one of important factors influencing job burnout of clinical nurses,so hospital managers should focus on building a good nurse-patient re-lationship and good worKing environment and looKing for positive countermeasures from three aspects of individual,organization and society to prevent and reduce the occurrence of job burnout of nurses.%目的::探讨护患关系对临床护士职业倦怠的影响,并提出相应的对策。方法:采用护士调查问卷和马氏职业倦怠量表( MBI-HSS)调查450名临床护士,分析不同护患关系对临床护士职业倦怠的影响。结果:影响护士职业倦怠检出率的因素是:护士执业环境自评状况、患者信任度、患者尊重度;影响各维度得分因素有:护士执业环境自评状况、患者信任度、患者尊重度、患者服务满意度,其中,执业环境自评好、患者信任度高、患者尊重度高的护士,情感衰竭、去人格化得分较低,职业倦怠程度轻(P<0.05);得分越高,其职业倦怠程度越重(P<0.05)。结论:护患关系是影响临床护士职业倦怠的重要因素,医院管理者应注重构建良好的护患关系和执

  16. Analysis of relationship between occupational stress and burnout of the clinical nurses in Changsha%长沙市临床护士职业压力与职业倦怠的相关性研究

    Institute of Scientific and Technical Information of China (English)

    席明霞; 卿利敏; 李丹; 黄冬枚

    2012-01-01

    目的 探讨长沙市临床护士职业压力与职业倦怠的关系,为医院临床护理管理者预防和干预临床护士职业压力和职业倦怠提供依据.方法 采用临床护士一般资料调查表、职业压力问卷和职业倦怠问卷对长沙市5所综合性医院的412名临床护士进行问卷调查.结果 临床护士职业压力总均分为(3.77±0.48)分,其中人际关系得分为(3.93±0.56)分居首位;职业倦怠总均分为(3.82±0.40)分,其中情感衰竭得分为(3.27±0.58)分居首位,职业压力和职业倦怠均处于高水平;低成就感与职业压力及其患者态度和职业发展维度呈正相关(P<0.05),情感衰竭与职业压力及其人际关系、患者态度、危重患者、职业发展维度呈正相关(P<0.05),职业倦怠及其人格解体维度与职业压力及其各维度均呈正相关(P<0.05).结论 长沙市临床护士的职业压力和职业倦怠均处于高水平,应引起医院管理者和社会的重视.%Objective To explore the relationship between occupational stress and the job burnout of clinical nurses in Changsha so as to provide the reference of prevention and intervention of occupational stress and the job bumout for the managers in hospitals. Methods A total of 412 clinical nurses in 5 general hospitals were recruited, and a general information questionnaire, Occupational Stress Scale and job Bumout Scale were employed. Results The mean score of occupational stress was (3.77 ± 0. 48) and the highest was the dimension of interpersonal relationship (3. 93 ± 0. 56). The mean score of job bumout was (3.82 ±0.40) and the highest was the dimension of emotional exhaustion (3.27 ±0.58). The scores of occupational stress and job bumout were at a high level. The score of low accomplishment was positively correlated with the occupational pressure (P < 0.05), and the score of emotional exhaustion was positively correlated with interpersonal relationship,patients'attitude,patients with

  17. TP、VEGF在结直肠癌中的表达及临床病理研究%The expression of TP, VEGF and its relationship with clinical Pathological significance in Colorectal Cancer

    Institute of Scientific and Technical Information of China (English)

    夏传生; 李娜萍; 吴纯东; 王义松; 王书刚

    2011-01-01

    目的 探讨胸苷磷酸化酶(TP)、血管内皮生长因子(VEGF)的表达及其与结直肠癌临床病理特征的关系.方法 应用免疫组织化学EnVision TM法检测88例结直肠癌组织中TP、VEGF的表达,结合临床病理特征进行分析.结果 正常结直肠黏膜上皮不表达TP和VEGF;TP表达于结直肠癌细胞和(或)间质内单个核细胞,VEGF表达于癌细胞.TP和VEGF的阳性表达率分别为42.05%(37/88)和23.86%(21/88).TP和VEGF在淋巴结转移及Duke's Ⅲ-Ⅳ期患者中的阳性率高于无淋巴结转移及Duke'sⅠ-Ⅱ期患者(P<0.05);TP阳性表达率在癌组织浸润至浆膜及浆膜外组高于浸润程度较浅组(P<0.05).结论 TP和VEGF的异常表达可能促进结直肠癌的浸润与转移.%Objective To investigate the expression of thymidine phosphorylase(TP) and vascular endothelial growth factor (VEGF) and its relationship with clinical pathological charucteristies of colorectal cancer. Metods Immunohistochemical staining method EnVision TM was used to investigate the expression of TP and VEGF in 88 cases of colorectal cancer and its relationship with clinical pathology . Results TP and VEGF were not expressed in normal colorectal mucosa, but TP expression in cancer tissue was observed in both cancer cells and (or) single nucleus cells of the mesenchyme. VEGF expression in cancer tissue was observed in the cancer cells. The positive expression rate of TP and VEGF was 40. 05% (37/88) and 23. 86% (21/88) respectively in colorectal cancer. Higher in the cases of lymph node metastasis and Duke,s Ⅲ-Ⅳ than in those without lymph node metastasis and Duke,s Ⅰ-Ⅱ (P<0.05). The positive expression rate of TP was higher in the cancer tissue invading the serosa and beyond (P<0. 05). Conclusion The anomalous expression of TP and VEGF in colorectal cancer may promote the invasion and metastasis of colorectal cancer.

  18. Clinical value of detection level of serum PCT in AECOPD and its relationship with lung function%AECOPD血清PCT检测的临床价值及其与肺功能的关系

    Institute of Scientific and Technical Information of China (English)

    呼新建; 常晓悦; 边喜明; 丁丽芳; 贾小青; 杜淑珍

    2011-01-01

    目的 探讨AECOPD血清PCT检测的临床价值及与肺功能的关系.方法 选取56例AECOPD住院患者,采用酶免法测定血清PCT水平并行痰细菌半定量培养,与同期COPD稳定期及健康成人做对照;AECOPD血清PCT浓度分别与炎症指标、FEV1%预计值行相关分析.按COPD分级标准将AECOPD再次分组,比较血清PCT浓度.结果 AECOPD患者血清PCT水平明显增高,与痰培养结果无明显关系,血清PCT水平与炎症指标呈正相关,与FEV1%预计值呈负相关,肺功能严重损害血清PCT水平明显升高.结论 血清PCT水平对判断AECOPD下呼吸道细菌感染及严重程度有一定的临床价值,与肺功能急性损害有关.%Objective To investigate the clinical value of detection serum PCT in Acute Exacerbation of Chronic Obstructive Pulmonary Disease and the relationship with lung function.Methods The serum PCT level of 56 AECOPD inpatients and 20 stable patients and 20 healthy adults was measured by ELISA, and the 56 AECOPD inpatients were simultaniously done semi-quantitative sputum culture,their levels of serum PCT level was compared and analyzed.The correlation between the serum PCT of AECOPD patients with inflammatory markers, FEV1 % prediction were analyzed.AECOPD patients according to COPD grading standards wound be grouped again, and compared the serum PCT concentrations.Results The serum PCT level of AECOPD significatly increased, and no significant relationship with sputum culture results ,and positively correlated with inflammatory markers,and negatively correlated with FEV1 % prediction ,serum PCT level significatly increased while lung function seriously damaged.Conclusions The serum PCT level is some clinical value for judging AECOPD combined lower respiratory tract bacterial infections and the severity, and it is related with acute lung function damaging.

  19. The level of learning motivation and teacher-student relationship among nursing students during clinical practice%护理实习学生学习动机和师生关系的研究

    Institute of Scientific and Technical Information of China (English)

    任艳; 胡晓莹

    2012-01-01

    目的 调查护理实习学生的学习动机和师生关系状况,探讨其影响因素,并分析两者的关系.方法 采用方便抽样法,抽取江西省3家三级甲等医院的护理实习学生489名为对象,应用一般情况调查表、师生关系问卷、学习动机量表对其进行问卷调查.结果 学习动机各维度评分为:深层动机(3.52±0.55)分,成就动机(3.33±0.57)分,表层动机(3.10±0.49)分;亲密性为深层动机、学习动机最强影响因子;支持性为成就动机最强影响因子;择业意向对深层动机、成就动机有预测作用.师生关系各维度评分为;支持性(3.68:±0.75)分,满意性(3.62±0.66)分,亲密性(3.21±0.69)分,冲突性(1.63±0.52)分;表层动机对师生关系有负向预测作用,是支持性、冲突性的重要预测因子;成就动机、深层动机对师生关系有较强的正向预测作用,其中,深层动机是支持性、满意度、亲密性和冲突性的重要预测因子,成就动机是支持性的重要预测因子;择业意向、亲属从医情况、医院性质、年龄、学历对师生关系也有较强的预测作用.结论 护理实习学生的师生关系和学习动机受多种因素影响,师生关系和学习动机是相互促进的,培养护理学生学习兴趣和构建融洽师生关系是必要的.%Objective To investigate the level of learning motivation and teacher-student relationship among nursing students during clinical practice,and to analyze their influencing factors, and the relationship. Methods Totally 489 nursing students were recruited from three 3-A hospitals in Jiangxi province. They were investigated by using Learning Motivation Scale and Teacher-Student Relationship Questionnaire. Results The factor scores of learning motivation were ranked as deep motivation (3.52±0.55),achievement motivation(3.33±0.57) and superficial motivation(3.10±0.49). Intimacy was the strongest influencing factor of deep motivation and general learning

  20. Clinical studies about the relationship between atrial fibrillation and serum uric acid in patients with chronic heart failure%慢性心衰患者血尿酸和房颤关系的临床研究

    Institute of Scientific and Technical Information of China (English)

    覃玉花; 唐开奖; 宋星慧

    2014-01-01

    目的:研究慢性心衰(Chronic Heart Failure,CHF)伴房颤、(Atrial Fibrillation,AF)和伴窦性心律患者之间血尿酸( SUA)的关系,并评价AF的危险因素。方法选取280例CHF病人,其中82人为AF组、198人为窦律组;样本入选后,详细记录入选者的一般临床资料,并测定其临床生化指标,经心脏超声测定其左心室射血分数( LVEF),并对两组样本基本资料和所测临床数据进行比较。结果 AF组与窦律组相比,AF组年龄、SUA、hs-CRP和LVEF明显高于窦律组( P<0.05)。结论 AF的发生与SUA水平升高有关,可能是高尿酸血症介导了炎症的激活和氧化应激。我们的研究证明AF患者SUA和hs-CRP是明显升高的。%Objective To discuss the relationship of serum uric acid ( SUA) between arterial fibrillation ( AF) and normal sinus rhythm in chronic heart failure ( CHF ) patients and evaluating the risk factors of AF . Methods Totally 280 patients with CHF were included in the study .Of all, 82 patients had AF and 198 patients were in normal sinus .Recording the clinical features of patients enrolled in detailed , measuring clinical and biochemical indexes and determining left ventricular ejection fraction by echocardiography , then compared the basic data and the clinical data of the two groups .Results Comparing patients with AF and normal sinus rhythm , we found that age , SUA, hs-CRP and LVEF were significantly higher in patients group with AF ( P<0.05). Conclusions The occurrence of AF associated with elevated levels of SUA .The reason is maybe mediated by activation of hyperuricemia inflammation and oxidative stress . We have shown that patients with AF have significantly higher SUA .

  1. Preliminary analysis for the relationship between pathological findings and clinical manifestation in 22 cases died from infantile pneumonia%22例小儿肺炎尸检病理与临床关系的初步分析

    Institute of Scientific and Technical Information of China (English)

    张正霞; 王宗敏

    2001-01-01

    To explore the relationship between pathological findings and clinical manifestation, pathological and clinical data were collected and analyzed in 22 cases died from infantial pneumonia, and inference study were undertaken based on the theory of airway hydrokinetics (AHK).The results showed that all 22 cases suffered from airway obstruction. 2 of 5 cases with aspiration pneumonia were confirmed to have inhaled meconium, other 3 cases were probably correlated to gastro-esophageal reflux (GER).Among 17 cases with primary pneumonia, myocardial damage was observed in 14 cases, cerebral neural degeneration in 10,hepatic damage in 13 and renal damage in 9, respectively. Pathological changes were significantly correlated with the results of X-rays and blood-gas analysis.It is concluded that big changes of AHK can be induced by pneumonia, and should be pay attention to the features of the laminar flow and the eddy flow in the airway during the clinical treatment of infantial pneumonia.%为探讨小儿肺炎的临床诊疗问题,提倡气道气流动力学的实践应用,对1988年~1998年10年来死于婴儿肺炎的22例尸检资料与临床资料,以气道气流动力学理论为依据作出初步的推理性研究。结果发现22例尸检资料均有气道受阻。5例新生儿吸入性肺炎中2例为胎粪吸入,3例可能同胃食道返流(GER)所致的吸入有关;17例原发性肺炎中心肌损害达14例,脑神经细胞有变性者10例,肝、肾损害分别为13例和9例。病理改变与X线胸片及血气分析结果有较明显的相关性。提示肺炎会导致气道气流动力学的明显变化,在小儿肺炎临床治疗中应重视层流和涡流的理学特点。

  2. Discuss how to establish a good relationship between nurses and patients in clinical nursing work%浅谈如何在临床护理工作中建立良好的护患关系

    Institute of Scientific and Technical Information of China (English)

    段鹏飞; 闫立云; 赵福成

    2015-01-01

    Nursing staff in daily clinical nursing work, patients with all kinds of physical and mental disorders, and needs to build a good relationship between nurse and patients to ensure treatment process smoothly. Only has established the good relations between nurses and patients, patients' trust, to better meet the needs of the patients with a variety of, to provide high quality nursing service, truly achieve the goal of promote patients recover.%护理人员在从事日常临床护理工作中,出于其工作性质的特点以及需要服务的护理对象,护理人员需要与患有各类身心疾患的患者建立起良好的护患关系,以此确保治疗过程的顺利进行。只有建立了良好的护患关系,取得患者信任,才可更好的满足患者各种需要,为其提供真正优质的护理服务,达到促进患者康复的目的。

  3. Clinical Observation of Gestational Diabetes Blood Sugar Control and the Relationship between Pregnancy Outcomes%妊娠期糖尿病孕妇血糖控制与妊娠结局关系的临床探讨

    Institute of Scientific and Technical Information of China (English)

    王艳萍

    2015-01-01

    Objective To observe the relationship between glycemic control in pregnant women with gestational diabetes and pregnancy outcomes. Methods In perinatal care clinics screened out of 267 cases of gestational diabetes in pregnant women for the study, according to the treatment method is divided into group I is control blood sugar through diet therapy alone in the ideal range by 170 cases, Ⅱ group is the result of diet control combined with insulin therapy control of blood glucose in the desired range were 55 cases; Ⅲ group is not receiving systemic therapy in 42 cases, observed and compared three groups of patients with pregnancy outcome. Results RenGaoZheng three groups of patients, excessive amniotic fluid, infection, postpartum hemorrhage, diabetic ketoacidosis, a huge children, FGR, preterm children, fetal malformations, and neonatal respiratory distress syndrome, the incidence of hypoglycemia and cesarean section rate, differences between perinatal mortality were statistically significant (P0.05), Ⅲ were higher than ⅰ group and ⅱ group (P0.05),Ⅲ组均高于Ⅰ组和Ⅱ组(P<0.05)。结论妊娠期糖尿病孕妇经过合理治疗,控制血糖在理想范围,能明显改变妊娠结局。

  4. Lipid status and its relationship with hormones and anthropometric indices in Hirsute women

    Directory of Open Access Journals (Sweden)

    Mir Damadi SR

    2000-06-01

    Full Text Available Relationships among lipids, hormones and anthropometric indices of patients in a reproductive endocrinology outpatient clinic were investigated. Subjects were divided into 2 groups according to their hirsutism score (Hirsute score>=8, N=102; And non-hirsute score<8, N=83. Weight (Wt, height (Ht, waist (W and hip (H circumferences were measured in all women and serum levels of lipids, hormones and glucose were determined in about one half of them. Hirsute women were heavier and had higher waist to hip ratio (WHR and waist to height ratio, increased LDL and decreased progesterone levels (In all cases, P<0.04. In 26 subjects with a high serum androgen level (Testosterone, and"or androstenedione and/or DHEAS there was a significant correlation between triglyceride and testosterone levels (P<0.02. Multiple regression analysis showed that WHR was an independent variable for cholesterol and LDL; Age for triglyceride; Glucose for HDL; And androstenedione for the LDL/HDL ratio. It is concluded that altered blood lipid profiles in women with hirsutism and"or hyperandrogenism may be the result of obesity, testosterone or androstenedione blood levels.

  5. 盐酸青藤碱治疗髋骨性关节炎量效关系临床观察%Clinical observation on dose-effect relationship of Sinomenine hydrochloride in treating Hip arthritis

    Institute of Scientific and Technical Information of China (English)

    冯立清; 冯国燕; 马智勇; 张全玲; 李蕴麟; 王东霞; 王永花; 王家秀

    2015-01-01

    目的:通过观察盐酸青藤碱不同剂量关节腔注射治疗髋骨性关节炎的临床疗效及不良反应,探讨盐酸青藤碱治疗髋骨性关节炎的量效关系。方法:将132例门诊和住院的髋骨性关节炎患者随机分成治疗组和对照组。治疗组给予盐酸青藤碱注射液35mg关节腔内注射,每日1次,每10天为一疗程。对照组给予盐酸青藤碱注射液25mg关节腔内注射,每日1次,每10天为一疗程。结果:治疗组总有效率优于对照组(P<0.05),不良反应两组无差别。结论:盐酸青藤碱关节腔注射治疗髋骨性关节炎存在量效关系,35mg关节腔注射疗效明显优于25mg,不良反应无明显增加。%Objective:By looking at different sinomenine hydrochloride dose intra-articular injection in the treatment for hip arthritis clinical curative effect and adverse reactions of sinomenine hydrochloride treatment for hip arthritis, and the dose-effect relationship. Methods:132 cases of outpatient and hospitalization hip arthritis patients were randomly divided into treatment group and control group. Treatment group given hydrochloride sinomenine injection 35mg intra-articular injection, once a day, every 10 days for a course of treatment. Patients in the control group were given hydrochloride sinomenine injection 25mg intra-articular injection, once a day, every 10 days for a course of treatment. Results: The total effective rate in the treatment group was better than that in the control group (P injection in the treatment of hip joint inflammation in the presence of dose effect relationship, 35mg articular cavity injection curative effect is obviously superior to 25mg, no significant increase in adverse reactions.

  6. Study on the relationship between spiral CT Imaging findings and the clinical stages of stomach cancer%胃癌螺旋CT影像学表现与临床分期关系的研究

    Institute of Scientific and Technical Information of China (English)

    庞殿中

    2011-01-01

    Objective: To investigate the relationship beween the imaging futures and the clinical stage in patients with gastric cancer so as to assess the prcoperauve staging and to facilitate the treatment. Methods: 45 patients with pathologically confirmed gastric cancer patients underwent the preoperative low tension of water filling phase enhanced helical CT scan. The CT maximal diameter and thickness, strengthening side, and the thickness of peritumoral low density zone on three-dimensional image were compared with the intraoperative and postoperative pathological findings. Results;The thickness of lesionsi strengthened degree, and tumor low density zone thickness of the stomach cancer are closely related to the clinical stage. Conclusion: Enhanced spiral CT examination for gastric cancer can precisely assess the preoperative staging of gastric cancer and benefit to surgical selection and evaluation of prognosis.%目的:探讨胃癌患者CT影像学表现与胃癌临床分期关系的研究,做好胃癌患者术前分期评估,以利治疗.方法:采用西门子6层螺旋CT.对45例经病理证实为胃癌患者,术前行低张力水充盈螺旋CT三期增强扫描,将CT三维图像上肿瘤最大直径与厚度、强化方程度、肿瘤瘤周低密度区厚度.与术中大体病理及术后病理进行对照.结果:成像后病灶厚度、强化程度及瘤周低密度区厚度与胃癌临床分期密切相关(P<0.05).结论:增强螺旋CT对胃癌检查,可以为明确胃癌术前分期、选择术式及评估预后作出选择.

  7. Relationship between Family Function and Clinical Symptoms of Adolescent Patients with Somatoform Disorder%青少年躯体形式障碍患者临床症状与家庭功能的关系

    Institute of Scientific and Technical Information of China (English)

    邵云; 刘果; 王旭梅; 夏静; 战玉华; 豆立宁; 巩凯旋

    2013-01-01

    Objective To explore the relationship between family functions and clinical symptoms of adolescent patients with somatoform disorder. Methods A total of 136 middle school students with somatoform disorder were included in the study group, and 122 normal students were included in the control group. All subjects were asked to fill out the form of general information, Family Assessment Device ( FAD ) and Symptom Checklist 90 ( SCL - 90 ) . SPSS 11. 5 was used for data analysis. Results The total and factor scores of FAD ( except the factor of Roles and Affective Involvement) and SCL -90 were significantly higher in the study group than that in the control group ( P < 0. 01 ) . Except the factor of Roles, the factor scores of FAD was positively correlated with that of SCL - 90 in the study group ( P < 0. 05 ) . Conclusion Adolescent patients with somatoform disorder tend to have visible family dysfunction, which is correlated with the patients' clinical symptoms. Clinical treatment to adolescent somatoform should consider family therapy as a key component.%目的 探讨青少年躯体形式障碍患者的家庭功能状况及与临床症状的关系,为临床有效开展家庭治疗提供依据.方法 136例被临床诊断为躯体形式障碍的青少年(病例组)与122例对照者(对照组)共同完成一般资料调查表、家庭功能评定量表和症状自评量表的填写.采用SPSS 11.5统计软件对两组数据进行统计分析;采用χ2检验和t检验对病例组与对照组的一般资料进行比较;两组家庭功能评定量表及症状自评量表各因子比较采用t检验;采用Person法对病例组家庭功能评定量表评分与症状自评量表评分关系进行分析.结果 病例组家庭功能评定量表(除外角色因子与情感介入因子)、症状自评量表总均分及各因子得分均高于对照组,差异有统计学意义(P<0.01);除角色因子以外,病例组家庭功能评定量表其他各因子得分与症状自评

  8. 病毒感染与免疫性血小板减少性紫癜的临床观察%Clinical observation of the relationship between immune thrombocytopenic purpura and virus infection

    Institute of Scientific and Technical Information of China (English)

    张永卓

    2013-01-01

    Objective To investigate the relationship between immune thrombocytopenic purpura (ITP) and virus infection.Methods A retrospectively analysis was based on the clinical records.ELSIA tests of EBV and CMV antibody were performed at 50 children suffered from ITP.The clinical characteristics and therapeutic effects in viral infection group and non-viral infection group were compared.Results Thirty-eight children in 50 cases who suffered from ITP were infected by EBV or CMV.Between viral infection group and non viral infection group,there was no significant difference in clinical features,hemoglobin and platelet (P > 0.05).But,it showed that the effects of viral infection group were better than those of non viral infection group at the time of two months and six months after treatment (P < 0.05).There were 18 cases ineffective in the viral infection group for six months treatment.There was the higher chronic tendency incidence in viral infection group (47.3%) than that in the non viral infection group (8.3%).Conclusions Most ITP patients infected by virus.Virus associated ITP had poor treatment effect and is easy to prolong course.%目的 探讨免疫性血小板减少性紫癜(ITP)与病毒感染的关系.方法 回顾性分析50例ITP儿童的临床资料,采用ELISA法检测50例ITP患儿血清病毒抗体(EB病毒及巨细胞病毒等),比较病毒抗体检测在病毒感染组及非病毒感染组ITP患儿中的临床特点及治疗效果.结果 病毒血清学检测:病毒感染38例,非病毒感染12例.病毒感染组与非病毒感染组比较:①两组临床表现、Hb及血小板计数比较差异均无统计学意义(P>0.05);②治疗后2个月效果比较差异有统计学意义(P<0.05),病毒感染组初始疗效较非病毒感染组治疗有效率低;③治疗后6个月两组疗效比较差异有统计学意义(P<0.05),治疗后6个月病毒感染组无效18例(47.4%),且呈慢性倾向,明显高于非病毒感染组(8.3%).结论

  9. Relationship between Stressor and Self-efficacy of Nursing Undergraduates in Initial Stage of Clinical Practice%本科护生实习初期压力源与自我效能感的相关性研究

    Institute of Scientific and Technical Information of China (English)

    雷慧; 王燕

    2011-01-01

    目的 了解本科护生临床实习初期压力源与自我效能感现状及两者的相关性.方法 采用自制的本科护生临床实习压力源问卷及一般自我效能感量表对170名本科护生进行问卷调查.结果 本科护生临床实习初期压力源依次为:自身知识与技能、工作性质与内容、自身及就业、病人护理、教学组织与管理、医院环境与人际关系;一般自我效能感总均分为(2.57±0.46)分,高于中间分2.5水平;各压力源得分与自我效能感均呈负相关( r=-0.61~-0.30,P<0.001).结论 本科护生临床实习初期压力源与自我效能感呈负相关.护理教育工作者应重视培养临床实习本科护生的自我效能感,加强本科护生实习前护士职业素质及护理操作技能培训,实习中尤其是实习初期的心理支持,提高本科护生的自我效能感,以减轻临床实习压力,提高实习质量.%Objective To probe into the relation between stressors and self-efficacy of nursing undergraduates during their initial stage of clinical practice. Methods A total of 170 nursing undergraduates were surveyed with General Self-efficacy Scale (GSES)and a self-designed stressors questionnaire. Results The stressors in their initial stage of clinical practice included the followings in sequence: knowledge and skill, jobs, employment, patient nursing, teaching organization and management environment of hospital and interpersonal relationship. The score of GSES of nursing students was (2.57 ±0.46) which was above the moderate level of 2.5. There was negative correlation between each stressor and self-efficacy of nursing students (r=-0.61 ~-0.30, P<0.001). Conclusion There is negative correlation between stressors and self-efficacy of nursing undergraduates during their initial stage of clinical practice.Importance should be attached to enhance self-efficacy and professional quality of nursing of nursing students. Psychological support is expected during

  10. Clinical Significance of Establishing Relationship between the HBsAg Test and HBV DNA%乙肝五项测定结果与HBV DNA的关系及其临床意义

    Institute of Scientific and Technical Information of China (English)

    李昕; 张荣波

    2011-01-01

    Objective To explore the internal relationship and the clinical significance of HBVM( HBsAg, Anti-HBs,HBeAg,Anti-HBe, Anti-HBc )and HBV DNA( Hepatitis B Virus DNA ). Methods HBVM and HBV-DNA of 300 HBV patients were examined by enzyme linked immunosorbent assay( ELISA )and quantitative fluorescence PCR technique respectively. Results Of all the clinical results of 300 HBV patients,110 patients showed HBsAg( + ),HBeAg( + ),HBcAb( + )( HBV DNA positive rate 99. 1% ),85 patients showing HBsAg( + ), HBeAb( + ),HBcAb( + )( HBV DNA positive rate 69.4% ), 39 patients showing HBsAg( + ),HBcAb( + )( HBV DNA positive rate 53.8% ),53 patients showing HBeAb( + ),HBcAb( + )( HBV DNA positive rate 35.8% ). HBV DNA positive rate of HBsAg( + ),HBeAg( + ),HBcAb( + ) and HBsAg( + ), HBeAb( + ), HBcAb( + ) were different significantly( x2 = 35. 406, P < 0.05 ). Conclusion The results of HBsAg and HBV-DNA are closely related with different clinical meanings,which makes it necessary to combine the two results for a correct diagnosis and treatment.%目的探讨乙型肝炎(乙肝)五项结果和HBV DNA检出情况间的关系和临床意义.方法运用聚合酶链反应法检测300例乙肝血清的HBV DNA,并用酶联免疫吸附实验法进行乙肝五项的测定,对结果进行比较分析.结果 300例乙肝门诊的患者中乙肝五项的结果为110例HBsAg(+)、HBeAg(+)、HBcAb(+)(大三阳),其HBV DNA的阳性率为99.1%,85例HBsAg(+)、HBeAb(+)、HBcAb(+)(小三阳),其HBV DNA的阳性率为69.4%,39例HBsAg(+)、HBcAb(+),其HBV DNA的阳性率为53.8%,53例HBeAb(+)、HBcAb(+),其HBV DNA的阳性率为35.8%.大三阳和小三阳的HBV DNA阳性率比较差异有统计学意义(χ2=35.406,P<0.05).结论乙肝五项的结果与HBV DNA的结果有着密切的联系,并且都具备各自的临床意义,因此两者必须结合才能正确地对乙肝患者的病情作出正确分析和判断.

  11. Relationships Economics

    OpenAIRE

    Israelsen, L. Dwight; Ratliff, Richard L.

    1999-01-01

    The concept of the importance of healthy relationships in the economic system can be traced back to Adam Smith's writings of the last quarter of the 18th century. Smith believed that self-interest, the profit motive, competition, and frequent human interaction in the marketplace, within the framework of the rule of law, would induce market participants to develop moral virtues of honesty, generosity, and trust. Sellers who failed to develop these attributes would lose customers to competitors...

  12. 腹膜透析患者门诊随访频率与生存率关系的研究%Relationship between follow-up frequency at the outpatient clinic and their survival in peritoneal dialysis patients

    Institute of Scientific and Technical Information of China (English)

    杨桂鲜; 韩庆烽; 周晓玲; 孙庆华; 聂建东; 孙玲华; 史均宝; 何培丽

    2012-01-01

    Objective To investigate the relationship between follow-up frequency at the outpatient clinic and their survival in peritoneal dialysis (PD) patients. Method We recruited 202 incident patients who started PD between September 2006 and September 2008. They were divided into two groups according to the follow-up frequency: once a month in a group (one month group), and once more than a month in another group (more than one month group). Their general information and clinical data including laboratory examinations, nutrition status, complications and outcome after PD for 3 months and at the endpoint of the study were analyzed. Results At the beginning of PD, there were no significant differences in these parameters between the two groups, except that patients from rural area were different in the two groups (X2 = 10.629, P=0.005). At the end-point of the study, patients in the more than one month group had higher rate of hypertension (X2=15.561, P=0.000), lower serum albumin (t=2.219, P=0.028), higher serum phosphorus (t=-3366, P=0.001), and higher rate of malnutrition evaluated by SGA (X2=3.859, P=0.046), as compared with those in the one month group. Kaplan-Meier survival analysis demonstrated that survival rate and technical survival rate were significantly higher in the one month group than in the more than one month group (P=0.001 and P-0.002, respectively). Cox regression analysis showed that age, serum albumin, Kt/V and CCI were the independent factors affecting survival in PD patients, and that the follow-up frequency at the outpatient clinic was not included in the independent factors for survival (X2 = 40.673, P= 0.000). Conclusion The follow-up frequency at the outpatient clinic was unrelated to survival of PD patients. However, lower follow-up frequency at outpatient clinics may associate with malnutrition and more complications leading to poorer prognosis. We recommend the follow-up frequency of once a month for PD patients.%目的 探讨腹膜透析患

  13. HLA-B等位基因与新疆地区鼻咽癌相关性及其临床意义%HLA-B alleles and nasopharyngeal carcinoma in Xinjiang, China:relationship and clinical significance

    Institute of Scientific and Technical Information of China (English)

    胡云辉; 刘凯; 耿晓涛; 王若峥

    2016-01-01

    目的:探讨HLA⁃B等位基因多态性与新疆地区鼻咽癌的关系及其临床意义。方法纳入226例患者作为鼻咽癌组,207例健康志愿者作为健康对照组。采用PCR⁃SSP法对HLA⁃B等位基因进行检测。采用χ2检验两组之间、汉族和维吾尔族之间、鼻咽癌不同临床特征之间HLA⁃B等位基因频率差异。 Kaplan⁃Meier 法计算生存率并 Logrank 单因素分析与 HLA⁃B 等位基因频率关系。结果鼻咽癌组HLA⁃B∗46等位基因频率高于健康对照组( P=0.000),且HLA⁃B∗46等位基因频率在汉族存在差异性(P=0.000),而维吾尔族未发现差异性(P>0.05)。<30岁组HLA⁃B∗44等位基因频率高于≥30岁组( P=0.029);分化型非角化性癌和T1+T2期HLA⁃B∗48等位基因频率分别高于未分化型非角化性癌和T3+T4期( P=0.029)。鼻咽癌5年OS、DFS、DMFS、LRFS率与HLA⁃B∗46(P=0.118~0.502)、HLA⁃B∗44(P=0.761~0.804)及HLA⁃B∗48(P=0.308~0.727)表达状态无关。结论 HLA⁃B∗46等位基因可能为新疆地区汉族鼻咽癌的易感基因,而HLA⁃B∗44可能与较早发病年龄有关,HLA⁃B∗48可能与病理类型及T分期有关。故HLA⁃B等位基因可能与鼻咽癌发生、发展有关。%Objective To explore the relationship between HLA⁃B allele polymorphisms and nasopharyngeal carcinoma ( NPC) in Xinjiang, China and its clinical significance. Methods A total of 226 patients were assigned to NPC group, while 207 healthy volunteers were assigned to control group. PCR amplification with sequence⁃specific primers was used to determine HLA⁃B alleles. Comparison of HLA⁃B allele frequency between the above two groups, between Han and Uygur populations, and between patients with various clinical characteristics of NPC was made by chi⁃square test. The Kaplan⁃Meier method was used to calculate the survival rates and the log⁃rank univariate

  14. Clinical Research on the Relationship between Insulin Resistance and Colorectal Cancer%胰岛素抵抗与结直肠癌关系的临床研究

    Institute of Scientific and Technical Information of China (English)

    叶帅; 陈明卫; 李永翔; 余昌俊; 汪圣毅

    2012-01-01

    Objective To investigate the relationship between insulin resistance and colorectal cancer( CRC ). Methods A case-control study was performed to compare the clinical data of the CRC group (patients with newly diagnosed CRC, re=312) and the control group (adults in healthy examination, n=286), including blood fasting glucose and insulin levels, insulin resistance index (HOMA-IR), body mass index (BMI), family history of diabetes and CRC, personal habits of smoking and drinking, serum cholesterol, triglyceride and adiponectin levels. Results (1 )Compared with the control group, BMI and the proportion of CRC family history in the CRC group increased markedly (P0.05). (2)Logistic analysis showed that the age, gender, diabetes history, smoking, drinking, blood lipid, FPG, BMI, WHR and adiponectin had no marked relationship with CRC, but FINS (OR=4.37, 95%CI=3.21~7.23), HOMA-IR(OR=6.68, 95% CI=3.79~9.53), colorectal cancer family history (OR =2.31, 95% CI=1.83~5.64) had significant relationship with CRC. Conclusion There may be some relationship between IR and CRC. IR is an independent risk factor for CRC.%目的 探讨胰岛素抵抗(IR)与结直肠癌(CRC)发病的关系,为CRC病因学探索及CRC的预防研究提供思路.方法 收集新诊断的312例CRC患者的临床资料作为病例组,选择286名健康体检者作为对照组.比较两组人群间空腹血糖(FPG)、空腹胰岛素水平(FINS)、稳态模型胰岛素抵抗指数(HOMA-IR)、体质指数(BMI)、腰臀比(WHR)、糖尿病家族史、结直肠癌家族史、吸烟、饮酒等生活行为以及血脂、血脂联素水平等方面的差异.结果 CRC组BMI、CRC家族史比例均高于对照组,差异有统计学意义(P<0.05,P<0.01),且CRC组和对照组lnHNS、lnHOMA-IR分别为(2.92±0.51)、(2.46±0.45) mU/L和(1.49±0.51)、(1.02±0.41),差异有统计学意义(P<0.05,P<0.01),而CRC组脂联素水平[(10.1±2.9)mg/L]明显低于对照组[(13.2±2.6)mg/L

  15. Analysis of relationship between age at onset and clinical features of migraine%发病年龄与偏头痛临床特点的关系分析

    Institute of Scientific and Technical Information of China (English)

    冯智英; 李颖; 邹静; 李焰生

    2011-01-01

    目的 分析发病年龄与偏头痛临床特点的关系,为临床判断偏头痛的预后提供参考.方法 收集门诊诊断为偏头痛的连续患者447例,其中先兆性偏头痛(MA组)62例,无先兆性偏头痛(MO组)385例.记录两组患者的年龄、性别、头痛发病年龄(AAO)、首次就诊年龄、病程、家族史以及头痛强度、频率和持续时间等相关资料.两组患者按AAO进行再分组(≤18岁为未成年组,>18岁为成年组),分别对AAO与家族史和头痛强度、频率、持续时间的关系进行统计学分析.结果 MA组和MO组患者中女性分别占81.3%和66.1% (P <0.05),两组患者的首次就诊年龄、病程和头痛持续时间比较,差异均有统计学意义(P<0.05).在MO患者中,未成年组与成年组的首次就诊年龄、病程、家族史及头痛频率和持续时间比较,差异均有统计学意义(P<0.05).多变量Logistic回归分析发现,就诊年龄、病程、家族史、头痛频率是独立危险因素.结论 起病早、家族史明显、头痛严重的偏头痛患者,预后较差;在中国人群中,AAO可作为反映偏头痛预后的指标之一.%Objective To investigate the relationship between age at onset (AAO) and clinical features of migraine so as to provide references for prognosis estimation of migraine. Methods Four hundred and forty-seven consecutive patients with migraine were enrolled, among whom 62 were migraine with aura ( MA group), and 385 were migraine without aura ( MO group). The related data about age, gender, AAO, age of first diagnosis, course of disease, family history, intensity of migraine, frequency of migraine and duration of migraine of patients in two groups were recorded. Patients in both groups were subdivided into immaturity group ( ^ 18 years old) and adult group( > 18 years old) respectively. The relationship between AAO and family history, intensity of migraine, frequency of migraine and duration of migraine was statistically

  16. A clinical study on the relationship between oral hygiene and chronic gastritis.%口腔卫生与慢性胃炎关系的临床研究

    Institute of Scientific and Technical Information of China (English)

    陈发明; 孙海花; 刘民; 张修平; 邓玲玲

    2001-01-01

    目的:为探讨口腔卫生与慢性胃炎的关系。方法:76例胃粘膜幽门螺杆菌(Helicobacterpylori,Hp)检测阳性慢性胃炎患者为慢性胃炎组,72例健康自愿者组成对照组,对所有受检者进行口腔卫生检查,并对其牙菌斑Hp进行检测,比较两组的差别;慢性胃炎组随机分成A、B两组后接受抗Hp治疗,A组同时进行口腔治疗与口腔教育,B组为对照,3月后观察抗Hp治疗的疗效,比较两组的差别。结果:慢性胃炎组口腔卫生状况明显较对照组差(P<0.01),且口腔卫生状况与慢性胃炎程度有关(P<0.05);牙菌斑Hp检测结果亦显示口腔卫生愈差、慢性胃炎愈严重,Hp阳性率愈高。3月后A组的疗效明显优于B组。结论:口腔卫生好坏与慢性胃炎的发病密切相关,Hp寄生于牙菌斑可能是导致慢性胃炎发病和复发的一个重要因素。%Objective:To investigate the relationship between oral hygieneand chronic gastritis.Methods:76 patients with chronic gastritis (Helicobacter pylori polymerase chain reaction detection were positive, Hp-PCR positive) and 72 controls were studied their oral hygiene and the Hp in their dental plaque.Chronic gastritis patients were received anti-Hp therapy and then divided into 2(A and B)groups.A group was treated by supergingival subgingival curettage,and received oral health education while B group was compared.Results:There were significant differences of Hp positive rate and debris index(DI),calculus index(CI),plaque index(PLI),gingival index(GI) between chronic gastritis group and control group(P<0.01),and they all related with the severity of chronic gastritis(P<0.01).Oral hygiene treatment and oral health education are benefit for anti-Hp therapy of chronic gastritis.Concusions:It is indicated that the relationship between oral hygiene and chronic gastritis is close clinically,Hp in dental plaque perhaps is one of the way to Hp infecton.

  17. Relationship between Mild Fetal Lateral Cerebral Ventriculomegaly and Clinical Prognosis%胎儿侧脑室轻度增宽的超声测量结果与临床预后的关系研究

    Institute of Scientific and Technical Information of China (English)

    傅文英; 孙耕妹; 赵佩英

    2011-01-01

    目的 探讨胎儿轻度侧脑室增宽与临床预后的关系.方法 选择产前检查发现侧脑室后角轻度增宽的胎儿34例为观察组,侧脑室正常的胎儿30例为对照组,进行新生儿神经行为(NBNA)评分,比较两组有无差异.结果 34例胎儿侧脑室轻度增宽中仅1例染色体为21-三体,1例未查染色体;有3例在妊娠中期首次发现侧脑室轻度增宽后因加重而引产.两组胎儿性别构成比比较,差异无统计学意义(P>0.05);观察组胎儿出生后NBNA评分较对照组高,差异有统计学意义(P<0.05).结论 侧脑室轻度增宽的胎儿,尤其是>12 mm的胎儿,出生后发生神经系统发育不良的风险较侧脑室正常胎儿增加;侧脑室轻度增宽与胎儿性别无关;因胎儿脑室扩张是一动态的过程,如不合并染色体和其他的结构异常,大部分预后良好.%Objective To investigate the relationship between mild fetal lateral cerebral ventriculomegaly and the clinical prognosis. Methods Totally 34 fetuses were found to be with mild lateral cerebral ventriculomegaly ( MLCV group ); 30 fetuses with normal lateral cerebral ventricles were enrolled as control group. Neonatal behavioral neurological assessment ( NBNA ) was performed. Results In the MLCV group, one case was with trisomy 21, one did not undergo chromosome screening, and three were aborted due to exaggerated MLCV in the 2nd trimester. The proportions of sex showed no significant difference between these two groups ( P > 0. 05 ). The NBNA grade was significantly higher in MLCV group than in control group ( P <0. 05 ). Conclusion Fetuses with MLCV ( especially when > 12 mm ) have increased risks of nervous system ahnormalities. However, since FLCV is a dynamic process , and the prognosis can be good if no unusual chromosome and other abnormal structure exist.

  18. RESEARCH ON RELATIONSHIP BETWEEN TREATMENT ADHERENCE AND CLINICAL MANIFESTATIONS OF HYPERTENSIVE RETINOPATHY%治疗依从性与高血压视网膜病变临床表现关系的研究

    Institute of Scientific and Technical Information of China (English)

    孙春晖

    2014-01-01

    Objective To explore the relationship between treatment adherence and clinical manifesta-tions of hypertensive retinopathy .Methods Questionnaires were distributed to community members to in-vestigate the amount of knowledge they have known on hypertension retinopathy .By means of adopting a series of positive measures ,we have strengthened the awareness of hypertensive retinopathy ,and taught people how to take medicine in a scientific and regulatory manner and how to prevent and control the dis-ease .Results For three successive years ,the prevalence of hypertensive retinopathy did not change signifi-cantly ( P >0 .05) .Different treatment adherence affected the development tendency of hypertensive reti-nopathy ( P < 0 .01 ) . Conclusion T he development pace of hypertensive retinopathy can be deferred as long as we strengthen the intervention of hypertension and focus on education as well as guidance of its treatment adherence .%目的:探讨不同的治疗依从性与高血压视网膜病变临床表现之间的关系。方法①发放问卷调查社区人员对高血压视网膜病变的知识了解度;②采用一系列积极措施,加强人们对高血压视网膜病变的认识,指导规范、科学用药及对该病的防控。结果①连续三年高血压视网膜病变罹患率变化不明显(P >0.05);②不同的治疗依从性会影响高血压视网膜病变的发展趋势(P <0.01)。结论在加强社区高血压干预的基础上,注重治疗依从性的教育和指导,可延迟高血压视网膜病变的发展速度。

  19. Relationships of magnetic resonance imaging characters and clinic presentations of children cerebral palsy%儿童脑性瘫痪MRI特征与临床表现的相关性

    Institute of Scientific and Technical Information of China (English)

    王莹; 王海宝; 余永强; 徐丽艳; 陈玉萍

    2014-01-01

    目的通过分析脑性瘫痪( CP)患儿磁共振表现与其类型、粗大运动功能分级( GMFCS)及出生胎龄的关系,探讨MRI在小儿CP临床诊断中的价值。方法收集143例CP患儿的临床和MRI资料,回顾性分析其间相关性。结果MRI表现为室周白质损伤(PWMI)52例,弥漫性脑损伤31例,脑发育异常19例,局灶性脑血管意外11例,正常24例,无法分类性病变6例。不同类型MRI表现的GMFCS分布差异有统计学意义(χ2=87.974,P =0.000, Fisher 精确检验)。 PWMI的患儿中,早产儿多见,且主要为双瘫及偏瘫, GMFCSⅠ~Ⅲ级较多。弥漫性脑损伤中,四肢瘫及不随意运动型常见,GMFCS多为重度障碍。脑发育异常及局灶性脑血管意外足月儿多见,GMFCS显示为前者重度障碍多见,后者轻度障碍多见。结论 CP患儿MRI表现与CP类型、GM-FCS、出生胎龄有密切关系,对CP的早期诊断及预后评估有重要价值。%Objective To explore the valuation of MRI in clinic diagnosis of children cerebral palsy( CP) by tes-ting relationships between types of CP, gross motor function( GMFCS) ,gestational age at birth and MRI findings of the brain. Methods The clinic and MRI data were collected and their correlations were analyzed. Results A-mong 143 cases of cerebral palsy,52 cases were periventricular white matter injury( PWMI) ,31 cases were diffusive encephalopathy,19 cases were brain malformations,11 cases were focal cerebral vascular accident,24 cases were normal and 6 cases were unclassifiable. Distributions of GMFCS were significantly different among various neuroim-aging findings(χ2 =87.974,P=0.000,Fisher exact test). For PWMI, preterm infants were mainly involved with spastic diplegia or spastic hemiplegia, and GMFCS levels wereⅠ~Ⅲ. Diffusive encephalopathy was most com-monly shown in dyskinetic CP and spastic quadriplegia,and GMFCS levels were Ⅳ~Ⅴ. Brain malformations and focal cerebral vascular accident were common in term infant

  20. Relationship between completement 3 and the clinical and pathological features of diabetic nephropathy%补体C3与糖尿病肾病临床病理的关系

    Institute of Scientific and Technical Information of China (English)

    杨莉莉; 刘东伟; 刘章锁

    2013-01-01

    目的 探讨补体C3与糖尿病肾病临床与病理的关系.方法 选择116例于郑州大学第一附属医院肾脏内科经肾穿刺活检证实为糖尿病肾病的患者为研究对象,搜集患者肾活检病理资料,分析不同肾脏病理类型补体C3沉积的阳性率;进而以补体C3为依据,分为C3阳性组和阴性组,分别搜集两组的病史、相关实验室检查等临床及病理资料,比较不同组别患者临床和病理资料的差异.结果 补体C3在糖尿病肾病不同病理类型沉积的阳性率比较差异无统计学意义(P>0.05);补体C3沉积阳性组在病程、24h尿蛋白定量和糖化血红蛋白均高于补体C3沉积阴性组,差异有统计学意义(P<0.05);补体C3沉积阳性组较阴性组有较高的活动指数(6.5±1.9 vs4.5±1.2)和较低的慢性指数(4.8±1.7 vs5.9±2.4),差异有统计学意义(P<0.05).结论 补体C3在糖尿病肾病患者肾脏的沉积率较高,可能参与糖尿病肾病的发病及影响患者预后.%Objective To investigate the relationship between complement 3 and the clinical pathological features of diabetic nephropathy.Methods Pathological materials were collected from 116 patients with renal biopsy-proven diabetic nephropathy,and the deposition rate of complement 3 among different pathological types was analyzed.And then based on whether the renal biopsy speciments were deposited by complement 3,the cases were divided into two groups and the clinical pathological features between the two groups were compared.Results There was no significant difference of the deposition rate of complement 3 among different pathological types (P > 0.05).The group with complement 3 deposited has longer disease history,heavier proteinuria,and higher glycosylated hemoglobin (P < 0.05).Also the group with complement 3 deposited had higher activitation index and lower chronic index (P < 0.05).Conclusions The deposition rate of complement 3 was high in diabetic nephropathy

  1. Relationships of magnetic resonance imaging characters and clinic presentations of children cerebral palsy%儿童脑性瘫痪MRI特征与临床表现的相关性

    Institute of Scientific and Technical Information of China (English)

    王莹; 王海宝; 余永强; 徐丽艳; 陈玉萍

    2014-01-01

    Objective To explore the valuation of MRI in clinic diagnosis of children cerebral palsy( CP) by tes-ting relationships between types of CP, gross motor function( GMFCS) ,gestational age at birth and MRI findings of the brain. Methods The clinic and MRI data were collected and their correlations were analyzed. Results A-mong 143 cases of cerebral palsy,52 cases were periventricular white matter injury( PWMI) ,31 cases were diffusive encephalopathy,19 cases were brain malformations,11 cases were focal cerebral vascular accident,24 cases were normal and 6 cases were unclassifiable. Distributions of GMFCS were significantly different among various neuroim-aging findings(χ2 =87.974,P=0.000,Fisher exact test). For PWMI, preterm infants were mainly involved with spastic diplegia or spastic hemiplegia, and GMFCS levels wereⅠ~Ⅲ. Diffusive encephalopathy was most com-monly shown in dyskinetic CP and spastic quadriplegia,and GMFCS levels were Ⅳ~Ⅴ. Brain malformations and focal cerebral vascular accident were common in term infant patients, and for GMFCS levels the former were Ⅳ~Ⅴ,while the latter wereⅠ~II. Conclusion Correlations are significant between MRI findings with types of CP, gross motor function and gestational age at birth and it's important for MRI in earlier diagnosis and prognosis valua-tion of cerebral palsy.%目的通过分析脑性瘫痪( CP)患儿磁共振表现与其类型、粗大运动功能分级( GMFCS)及出生胎龄的关系,探讨MRI在小儿CP临床诊断中的价值。方法收集143例CP患儿的临床和MRI资料,回顾性分析其间相关性。结果MRI表现为室周白质损伤(PWMI)52例,弥漫性脑损伤31例,脑发育异常19例,局灶性脑血管意外11例,正常24例,无法分类性病变6例。不同类型MRI表现的GMFCS分布差异有统计学意义(χ2=87.974,P =0.000, Fisher 精确检验)。 PWMI的患儿中,早产儿多见,且主要为双瘫及偏瘫, GMFCSⅠ~Ⅲ级较多。弥漫性脑损伤中,四肢瘫及不

  2. MRI in temporal lobe epilepsy. Correlation between EEG, SPECT and clinical features

    Energy Technology Data Exchange (ETDEWEB)

    Uesugi, Hideji; Onuma, Teiichi; Matsuda, Hiroshi; Ishida, Shiro [National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, Tokyo (Japan)

    1996-02-01

    The relationship between MRI, SPECT, EEG and clinical features in temporal lobe epilepsy was investigated. Subjects were 162 patients (84 males, 78 females) whose average age was 38.1{+-}12.1 years. SPECT was carried out in 45 patients. The results were as follows: abnormal MR images were obtained in 36% of the group without epileptic discharge, and in 42% of the group with temporal spikes. There was no correlation between epileptic discharge in EEG and MRI abnormality. The lateralities of epileptic discharge and MRI were in disagreement in 9 of 39 patients (23%), indicating that determining the epileptic focus from scalp EEG was difficult. There was no correlation between the basic activity in EEG and abnormality in MRI. The rate of abnormal SPECT (89%) was higher than that of abnormal MRI (40%). The rate of the group with ictal automatism (52%) was higher than that of the group without ictal automatism (35%). The rate of abnormal MR images was high in the group with encephalitis (73%). The rate was higher in the group with febrile convulsion (62%) than in the group without it (28%). The rate of the abnormal MR images was higher in the group with a seizure frequency of at least several mal/month (48%) than in the group with a seizure frequency of less than several mal/year (29%). (author).

  3. MRI in temporal lobe epilepsy. Correlation between EEG, SPECT and clinical features

    International Nuclear Information System (INIS)

    The relationship between MRI, SPECT, EEG and clinical features in temporal lobe epilepsy was investigated. Subjects were 162 patients (84 males, 78 females) whose average age was 38.1±12.1 years. SPECT was carried out in 45 patients. The results were as follows: abnormal MR images were obtained in 36% of the group without epileptic discharge, and in 42% of the group with temporal spikes. There was no correlation between epileptic discharge in EEG and MRI abnormality. The lateralities of epileptic discharge and MRI were in disagreement in 9 of 39 patients (23%), indicating that determining the epileptic focus from scalp EEG was difficult. There was no correlation between the basic activity in EEG and abnormality in MRI. The rate of abnormal SPECT (89%) was higher than that of abnormal MRI (40%). The rate of the group with ictal automatism (52%) was higher than that of the group without ictal automatism (35%). The rate of abnormal MR images was high in the group with encephalitis (73%). The rate was higher in the group with febrile convulsion (62%) than in the group without it (28%). The rate of the abnormal MR images was higher in the group with a seizure frequency of at least several mal/month (48%) than in the group with a seizure frequency of less than several mal/year (29%). (author)

  4. How to Connect the Gap between Clinical Trials and Clinical Practice

    Institute of Scientific and Technical Information of China (English)

    SHANG Hong-cai; XU Hong-juan; CHEN Jing; ZHANG Bo-li; LI You-ping; Mike J Clarke

    2008-01-01

    Clinical research methods have been rapidly developing, and the design of clinical trials including traditional Chinese medicine is advancing. To a certain extent, all of these ensure that the results of clinical research are objective and scientific, but whether these results and the resulting guidelines or consensus have much practical significance on clinical practice is still controversial. The authors engage in both clinical practice and clinical research; they strongly feel that it is necessary to discuss the relationship between clinical trials and clinical practice. This essay discusses this relationship in four parts.

  5. 毛细支气管炎患儿临床严重程度与哮喘发生的相关因素分析%Relationship between clinical severity of infants with bronchiolitis and asthma and related factors

    Institute of Scientific and Technical Information of China (English)

    丁涛; 张士辉

    2015-01-01

    Objective To explore the relationship between clinical severity of capillary bronchitis in children and asthma and high risk factors for the development of asthma.Methods A retrospective analysis was conducted on the clinical data of 120 cases of capillary bronchitis in children admitted in Qihe County People ’ s Hospital from July 2012 to July 2104 to analyze the relationship between the incidence of asthma and the types of capillary bronchitis.Logistic analysis was carried out to analyze the high risk factors of asthma in children with capillary bronchitis.Results The incidence of asthma in children was 28.33%.It was 25.00% in children with mild capillary bronchitis and 39.29%in those with severe bronchitis, and the difference was significant (χ2 =4.03,P<0.05).Severe capillary bronchitis, parental smoking, allergic original positive, allergic rhinitis and family history of asthma were significantly correlated with asthma (χ2 value was 0.579, 8.774, 9.146, 5.704 and 36.729, respectively,OR value was 3.821, 5.830, 6.531, 4.321 and 26.592, respectively,95%CI was 1.157-12.498, 1.775-18.221, 1.720-18.231, 1.281-109.251 and 8.014-111.251, respectively, all P<0.05).Conclusion Passive smoking, family history of asthma and allergic constitution may be high risk factors for severe capillary bronchitis developing asthma, so they should be paid much attention to reduce the incidence of asthma fundamentally.%目的:分析毛细支气管炎患儿临床严重程度与哮喘发生的关系及其高危因素。方法回顾性分析齐河县人民医院自2012年7月至2104年7月收治的120例毛细支气管炎患儿的临床资料,分析其哮喘的发生率与毛细支气管炎疾病类型的关系,同时应用Logistic法分析毛细支气管炎患儿发生哮喘的高危因素。结果该组患儿哮喘发生率为28.33%,其中轻型毛细支气管炎患儿哮喘发生率为25.00%,重型毛细支气管炎患儿哮喘发生率为39.29%,两者哮喘

  6. CLINICAL BIOCHEMISTRY

    Science.gov (United States)

    Assessment of the health status of animals through measurement of cellular, biochemical, and macromolecular constituents in blood, secretions, and excretions has been variously referred to as clinical chemistry, clinical biochemistry, or clinical pathology. he genesis of this dis...

  7. The relationship between the MRI findings and clinical features in 22 full-term infants with neonatal hypoglycemia%足月新生儿低血糖22例磁共振表现与临床特征

    Institute of Scientific and Technical Information of China (English)

    顾秋芳; 胡黎园; 陈超; 曹云; 邵肖梅; 程国强; 王来栓; 朱珍; 周文浩

    2013-01-01

    Objective To evaluate the relationship between the MRI findings and clinical characteristics in full-term infants with neonatal hypoglycemia. Methods The clinical records of 22 neonates with isolated hypoglycemia who were referred to Children' Hospital of Fudan University from June 1, 2008 to June 30, 2011 were reviewed retrospectively. The patients were divided into two groups according to the early magnetic resonance imaging ( MRI ) findings: MRI - group ( n = 9 ) were patients who showed normal brain imaging while MRI + group ( n = 13 ) were patients who showed abnormal brain imaging finding. The clinical characteristics of neonatal hypoglycemia were compared between two groups. The brain injury patterns identified from early MRI scans were presented. Results The frequencies of risk factors for hypoglycemia were similar in two groups ( P = 0.054 ). The duration when hypoglycemia was first detected was 1( 0. 5 - 17 ) h in MRI - group and 46. 6( 12. 7 - 78. 3 ) h in MRI + group, respectively, P = 0. 000. MRI - group established stable blood glucose levels faster than the MRI + group, ( 54. 1 ± 18. 2 ) h vs ( 71. 6 ± 15. 1 ) h, P = 0. 023. The occurrences of symptoms were more frequent in MRI + group than MRI - group ( P = 0. 000 ). Among MRI + group, 10 had predominant bilateral parieto-occipital cortex and subcortical white matter abnormalities, 1 had unilateral occipital and parietal area lesions, 2 had punctate white matter lesions in periventricular region or centrum semiovale. Conclusions Screening and management of babies at risk for neonatal hypoglycemia are recommended. Infants who were identified less than 12 hours of postnatal age remained asymptomatic, and there were no changes in the MRI imaging. The duration from birth till establishment of the stable blood glucose levels might be suggestive of association with neuroimaging changes and long-term neurological changes. The most common area of hypoglycemia-associated brain injury was in the parietal

  8. Relationship between P-gp expression and clinical efficacy of transcatheter arterial embolization chemotherapy (TACE) in primary liver cancer and clinical significance%原发性肝癌 P-糖蛋白表达与肝动脉插管栓塞化疗疗效的关系及临床意义

    Institute of Scientific and Technical Information of China (English)

    吴照宇; 郭应兴; 雷进元; 于海东

    2015-01-01

    目的:检测肝癌细胞的多药耐药基因 MDR1及编码产物 P-gp(P-glycoprotein,P-gp)的表达并探讨其与原发性肝癌经肝动脉插管栓塞化疗(transcatheter arterial chemoembolization,TACE)疗效的关系及临床意义。方法选取2010年6月到2013年6月来我院接受手术治疗的108例原发性肝癌患者作为肝癌组研究对象,同时选取来我院行肝穿刺检查的50例健康者作为对照。采用实时荧光定量 PCR 测定各组肝组织中 MDR1的 mRNA 水平,并采用免疫组织化学法检测手术切除后的肝癌组织 P-gp 的表达。根据 P-gp 表达水平将患者分为耐药组和非耐药组,分析 P-gp 表达水平与原发性肝癌术后 TACE 治疗效果的关系。结果与对照组比较,肝癌组患者肝脏组织中 MDR1的 mRNA表达水平显著升高(P 2的患者76例,MDR1的 mRNA/正常水平<2的患者32例。免疫组织化学结果显示 P-gp 呈棕黄色,主要表达于肝癌细胞的细胞膜表面。其中 P-gp 蛋白阴性患者(非耐药组)35例,阳性患者(耐药组)73例。非耐药组患者化疗有效率(74.28%)明显高于耐药组患者(43.28%)(P <0.05)。非耐药组1、2年累积生存率为77.14%和42.86%,明显高于耐药组(54.12%和27.40%,P <0.05)。结论原发性肝癌组织中 MDR1编码产物 P-gp 异常过表达与肿瘤化疗耐药性相关,提示其可作为临床术后化疗用药的指导标志之一。%Objective To explore the relationship of MDR1 and its encoded product P-gp expressions with clinical efficacy of transcatheter arterial chemoembolization (TACE)in primary liver cancer and their clinical significance.Methods We selected 108 patients with primary liver cancer who came to our hospital between June 2010 and June 2013 as observation subjects.Meanwhile 50 healthy people in our hospital for liver biopsy were selected as controls.MDR1 mRNA level in observation group and control group was determined by real-time quantitative PCR.P-gp protein level was

  9. Age and Clinical Dengue Illness

    OpenAIRE

    Egger, Joseph R.; Paul G Coleman

    2007-01-01

    The relationship between age and risk for classic dengue fever has never been quantified. We use data from clinical patients to show that the relative risk of having classical disease after primary dengue virus infection increases with age. This relationship has implications for strategies aimed at controlling dengue fever.

  10. Digital Relationships

    DEFF Research Database (Denmark)

    Ledborg Hansen, Richard

    -­rich information and highly interesting communication are sky-­high and rising. With a continuous increase in digitized communication follows a decrease in face-­to-­face encounters and our ability to engage in inter-­personal relationships are suffering for it (Davis, 2013). The behavior described in this paper......-­‐Jones, 2011) for increases in effectiveness and efficiency we indiscriminately embrace digital communication and digitized information dissemination with enthusiasm – at the risk of ignoring the potentially dark side of technology. However, technology also holds a promise for better understanding precisely...... for the same reasons – that the growing amount of digitized communication “out there” represents data waiting to be sifted, analyzed and decoded. In this paper “Facebook behavior” refers to a particular behavior characterized by presenting your self and representations of selected self in the hope of getting...

  11. 妊娠期糖尿病临床治疗及其对妊娠结局的关系研究%Research of clinical treatment for gestational diabetes mellitus and its relationship with pregnancy outcome

    Institute of Scientific and Technical Information of China (English)

    关秀娟

    2015-01-01

    目的:探讨妊娠期糖尿病临床治疗方法,并分析与妊娠结局的关系。方法60例妊娠期糖尿病孕妇为研究对象,将其随机分为研究组与对照组,每组30例。研究组为入院治疗的孕妇,对照组为同期未入院治疗的孕妇。给予研究组孕妇饮食指导、胰岛素、控制血糖等对症治疗,比较两组围生儿并发症发生率及孕妇分娩方式。结果研究组围生儿并发症发生率为10.0%,明显低于对照组的63.3%,差异有统计学意义(P<0.05)。研究组顺产率为60.0%,明显高于对照组的23.3%(P<0.05);研究组剖宫产率为40.0%,明显低于对照组的76.7%,差异有统计学意义(P<0.05)。结论及时诊断妊娠期糖尿病并入院治疗,能有效控制孕妇血糖,降低围生儿并发症发生率,改善孕妇分娩方式。%Objective To investigate clinical treatment methods for gestational diabetes mellitus, and to analyze its relationship with pregnancy outcome. Methods A total of 60 pregnant women with gestational diabetes mellitus as the study subjects were randomly divided into research group and control group, with 30 cases in each group. The research group contained pregnant women treated in hospital, and control group contained pregnant women at the same period not in hospital. Symptomatic treatment of diet guide, insulin, and blood glucose control was given to the research group. Comparison was made on complications of perinatal infant and delivery ways between the two groups. Results The research group had incidence of complications of perinatal infant as 10.0%, which was much lower than 63.3%of the control group, and the difference had statistical significance (P<0.05). Eutocia rate was 60.0%in the research group, and that was much higher than 23.3%in the control group(P<0.05);The research group also had lower caesarean section rate as 40.0%than 76.7%of the control group, and the differences had statistical significance (P<0

  12. Relationship between genotypes and clinical phenotypes in patients from 7 hemophilia A families%7个血友病A家系基因型与临床表型分析

    Institute of Scientific and Technical Information of China (English)

    梁伟玲; 韦红英; 廖宁; 周竣荔

    2015-01-01

    Objective To study the mutation types of factor VIII (FVIII) gene in patients from 7 hemophilia A (HA) families and the relationship between FVIII gene mutations and clinical phenotypes. Methods A total of 8 patients from 7 HA families were recruited. The activated partial thromboplastin time (APTT) and factor VIII coagulant activity (VIII:C) in these patients were measured. Polymerase chain reaction (PCR) was performed to analyze FVIII gene intron 1 and 22 inversions. For patients without the FVIII intron inversions, direct sequencing was performed to determine their mutation types and other related members of their families were also tested by PCR and sequencing to analyze the corresponding mutation sites. Results The ranges of APTT and VIII:C of the 8 patients were 91.6-131 seconds and 0.8%-2%, respectively. FVIII gene intron 22 inversion was not detected, while intron 1 inversion was detected in one patient. There were 5 types of mutations in FVIII gene detected in the remaining 7 patients, including 6 patients with mutations in exon 14 and 1 patient with mutation in exon 23;all of the 5 types of mutations were single nucleotide mutations. Among the detected mutations in FVIII gene, p.His1202LeufsX16 (c.3666delA) detected in one patient was found to be a previously unreported mutation in FVIII gene. Conclusions FVIII gene exon 14 is a hot-spot mutation region and p.His1202LeufsX16 is found to be a novel mutation in FVIII gene.%目的:确定各家系凝血因子Ⅷ(FⅧ)基因突变类型,了解基因突变与临床表型的关系。方法对7个家系患者进行活化部分凝血酶原时间(APTT)及凝血因子Ⅷ凝结活性(FⅧ:C)检测,再采用PCR方法对7个血友病A家系患者进行内含子22、内含子1倒位检测,对检测结果阴性患者采用直接测序法确定基因突变类型,并对家系相关成员进行相应位点的扩增与测序。结果8例血友病A患者APTT为91.6~131 s,FⅧ:C为0.8%~2%

  13. The relationship between radiographic measurement and short-term clinical outcome of distal radius fractures%桡骨远端骨折影像学测量指标与近期疗效的关系

    Institute of Scientific and Technical Information of China (English)

    汤骏; 高伟阳; 徐华梓

    2008-01-01

    目的 通过对桡骨远端骨折患者的影像学测量,分析各影像学参数和近期疗效之间的关系.方法 对62例桡骨远端骨折闭合复位石膏外固定的患者,利用StarPACS影像系统进行测量,并记录所有患者X线片的桡骨高、掌倾角及尺偏角的情况,并分析影像学测量指标与自测腕关节功能之间的关系.结果 62例桡骨远端骨折中,有50例(占80.6%)经保守治疗后效果优良.当桡骨高大于6.0 mm,掌倾角大于5°,尺偏角大于18°时,自测腕关节功能优良率较高.影像学指标和自测腕关节功能的相关性桡骨高>掌倾角>尺偏角.结论 桡骨高、掌倾角及尺偏角等可以作为桡骨远端骨折治疗效果评估的影像学指标,手法复位后影像学不达标者应当重新复位或采用手术治疗,桡骨远端骨折时应当首先考虑桡骨高的恢复.%Objective To evaluate the relationship between radiographic measurement and short-term clinical omcome of distal radius fractures. Methotis Sixty-two cases of distal radius fractures treated with closed reduction and cast immobilization were involved in the study.The X-ray films were measured in the StarPACS system to acquire radial shortening,palmar tilt and radial inclination.The relationshiD between radiographic measurements and short-term wrist joint function was analyzed. Results Fifty out of 62 (80.6%)cases achieved good results.Better wrist joint function was observed when radial shortening was greater than 6.0 mm,palmar tilt greater than 5°and radial inclination greater than 18°.The correlation between radiographic measurement and wrist function Was tightest for radius shortening,followed by palmar tilt and radial inclination. Conclusion Radial shortening,palmar tilt and radial inclination can be used as radiographic criteria for evluating results in the treatment of distal radius fractures.If these criteria are not met after manual reduction,re-manipulation or surreal intervention should

  14. Clinical biophysics

    Energy Technology Data Exchange (ETDEWEB)

    Anbar, M.; Spangler, R.A.; Scott, P.

    1985-01-01

    Chapters are included on clinical decision making, principles of biomedical engineering, computers and their medical uses, clinical radiobiology, diagnostic x-ray radiology, clinical applications of ultrasonics, nuclear medicine, NMR imaging, diagnostic imaging, bioelectric techniques in diagnosis and therapy, biophysical aspects of the clinical laboratory, and biophysical aspects of modern surgery.

  15. Weel蛋白在鼻咽癌组织中的表达及其与临床预后的关系%Expression of Wee1 protein in nasopharyngeal carcinoma and its relationship with clinical prognosis

    Institute of Scientific and Technical Information of China (English)

    霍占江; 李伟; 高飞

    2016-01-01

    目的 探讨Wee1蛋白在鼻咽癌组织中的表达及其与临床预后的关系.方法 收集2005年1月至2010年12月期间在张家口市第一人民医院和中国人民解放军251医院耳鼻喉科住院患者70例,手术病理活检均明确诊断为鼻咽癌,应用免疫组织化学(EnVisionTM)法检测其Wee1蛋白表达,并与30例正常组织的表达进行比较,同时分析Weel蛋白的表达与鼻咽癌临床病理因素的关系及其5年生存率.结果 Wee1蛋白在鼻咽癌组织、正常组织中的阳性表达率分别为52.86%(37/70)、10.00%(3/30),两组的阳性表达率比较差异有显著统计学意义(P>0.01);Wee1蛋白的阳性表达与肿瘤直径、淋巴结转移、浸润邻近组织及EBV感染有关(P>0.05),与性别、年龄、组织学类型及肿瘤部位无关(P>0.05);Wee1蛋白阳性表达的鼻咽癌患者5年生存率为35.14%(13/37),明显低于Wee1蛋白阴性表达的81.82%(27/33),两组比较差异有显著统计学意义(P>0.01).结论 Wee1蛋白的异常表达不仅参与了鼻咽癌的发生,而且有利于癌细胞的浸润转移,对预测患者的生存预后也有参考价值.%Objective To investigate the expression of Wee1 protein in nasopharyngeal carcinoma and its rela-tionship with clinical prognosis. Methods Seventy patients with nasopharyngeal carcinoma were collected from the First People`s Hospital of Zhangjiakou City and the 251th Hospital of Chinese People's Liberation Army from January 2005 to December 2010, which were definitely diagnosed as nasopharyngeal carcinoma by surgery pathology biopsy. The ex-pression of Wee1 protein was detected by immunohistochemisty (EnVisionTM) in nasopharyngeal carcinoma tissues in the 70 patients and compared with that of normal tissues (n=30). The relationship between the expression of Wee1 protein and clinicopathological factors, the patients' five-year survival rate were analyzed byχ2 test. Results The positive expression rate of Wee1 protein was 52.86%(37/70) in

  16. 职业暴露与肺癌临床特征的相关性分析%Relationship between clinical characteristics of lung cancer patients regarding their occupational exposure

    Institute of Scientific and Technical Information of China (English)

    刘英宇; 王红阳; 张蕾

    2013-01-01

    目的 分析职业暴露人群肺癌发生及其特征.方法 对唐山市2110名有从事石棉、煤焦油、烟尘、重金属、橡胶等相关职业且年龄≥20岁的居民进行问卷调查(包括一般情况、工作年限、吸烟史和吸烟程度),另外收集378例医院就诊的肺癌患者,其中有职业暴露史149例,将其一般情况、肺外病变临床表现、胸部影像学、病理类型、伴随疾病和肿瘤转移情况等与其他职业患者比较.结果 在2110名有职业暴露的研究对象中,肺癌患者共621例(29.43%).男性患病率高于女性,但差异无统计学意义(P>0.05).调查显示,年龄、吸烟年限、吸烟程度以及从事职业暴露的工作年限均为肺癌患病的重要因素(P<0.01).两组患者在肺外病变临床表现的发生率和表现形式上的差异均无统计学意义(P>0.05);胸部影像学表现为阻塞性肺气肿,职业暴露组(36.91%)高于其他职业组(18.78%),差异有统计学意义(P<0.05);病理类型为鳞癌的概率,职业暴露组(36.24%)高于其他职业组(28.38%),但差异无统计学意义(P>0.05);后期肿瘤胸膜转移,职业暴露组(14.09%)也高于其他职业组(7.42%)(P<0.05).结论 职业暴露人群中吸烟程度重、年长者和职业暴露年限高者肺癌的发生率高,临床影像学表现多为阻塞性肺气肿,病理类型以鳞癌和后期肿瘤胸膜转移为多见.%Objective To study the relationship between clinical characteristics of lung cancer patients and their occupational exposure.Methods 2110 workers (≥20 years) who had been engaged in occupation that were exposed to risk factors of lung cancer,were asked to fill in questionnaires which included social demographic characteristics,length of service,smoking history and habits etc.378 cases with lung cancer admitted in the Tangshan Worker' s Hospital were selected and their clinical data including general information,symptoms or signs other than lungs

  17. Relationship between

    Institute of Scientific and Technical Information of China (English)

    TIAN; Lide

    2001-01-01

    [1]Craig, H., Isotopic variations in meteoric waters, Science, 1961,133: 17020703.[2]Dansgaard, W., Stable isotope in precipitation, Tellus, 1964, 14(4): 436-468.[3]Merlivat, L., Jouzel, J., Global climate interpretation of the deuterium-oxygen 18 relationship for precipitation, J. Geophys.Res.. 1979, 84: 5029-5033.[4]Jouzel, J., Merlivat, L., Deuterium and oxygen-18 in precipitation: modeling of the isotope effects during snow formation.J. Geophys. Res., 1984, 89(D7): 11749-11757.[5]Sonntag, C., Klitzsch, E., Lohnert, E. P. et al., Palaeoclimatic information from deuterium and oxygen-18 in Carbon- 14-dated North Saharan groundwaters, in Isotope Hydrology, IAEA,Vienna, 1979, 569-581.[6]Armengaud, A., Koster, R. D., Jouzel, J. et al., Deuterium excess in Greenland snow: analysis with simple and complex models, J. Geophys. Res., 1998, 103(D8): 8947-8953.[7]Jouzel, J., Merlivat, L., Lorius, C., Deuterium excess in an East Antarctic ice core suggests higher relative humidity at the oceanic surface during the last glacial maximum, Nature, 1982, 299 (5885): 688-691.[8]Qin Dahe, Ren Jiawen, Wang Wenti, et al., Distribution of δD in 25 cm surface snow across the Antarctic, Science in China, Ser. B, 1992,22(7): 768-776.[9]Yao Tandong, Ding Liangfu, Pu Jianchen et al., Characteristic of δ 18O in snow and its relation with moisture sources in Tanggula Mountains, Tibetan Plateau, Chinese Science Bulletin (in Chinese), 1991, (20): 1570-1573.[10]Zhang Xinping, Shi Yafeng, Yao Tandong, Variational features of precipitation, δ 18O in Northeast Qinghai-Tibet Plateau.Science in China, Ser. D, 1995, 38(7): 854-864.[11]Zhang Xinping, Yao Tandong, Relations between weather systems affecting Tibetan Plateau and oxygen isotope in precipitation, Journal of Glaciology and Geocryology (in Chinese), 1995, 17(2): 125-131.[12]Tian Lide, Yao Tandong, Yang Zhihong, δ18O in precipitation and moisture sources upon the Tibetan Plateau, Cryosphere

  18. The Prospective Oral Mucositis Audit: relationship of severe oral mucositis with clinical and medical resource use outcomes in patients receiving high-dose melphalan or BEAM-conditioning chemotherapy and autologous SCT.

    NARCIS (Netherlands)

    McCann, S.; Schwenkglenks, M.; Bacon, P.; Einsele, H.; D'Addio, A.; Maertens, J.; Niederwieser, D.; Rabitsch, W.; Roosaar, A.; Ruutu, T.; Schouten, H.; Stone, R.; Vorkurka, S.; Quinn, B.; Blijlevens, N.M.A.

    2009-01-01

    The Prospective Oral Mucositis Audit was an observational study in 197 patients with multiple myeloma (MM) or non-Hodgkin's lymphoma (NHL) undergoing, respectively, high-dose melphalan or BEAM chemotherapy and autologous SCT at 25 European centres. We evaluated the relationship between severe oral m

  19. Clinical Trials

    Science.gov (United States)

    Clinical trials are research studies that test how well new medical approaches work in people. Each study answers ... prevent, screen for, diagnose, or treat a disease. Clinical trials may also compare a new treatment to a ...

  20. 婴幼儿病毒感染与腹泻相关临床参数的关系分析%Analysis of relationship between viral infection and diarrhea-related clinical parameters in infants

    Institute of Scientific and Technical Information of China (English)

    施前锋; 潘新娣; 王叶萍; 邵伟芳; 钱娇赟; 孙爱华

    2015-01-01

    目的:研究婴幼儿病毒感染与腹泻相关临床参数的关系,为婴幼儿病毒性腹泻的诊治和预防提供依据。方法收集124例5岁以下腹泻患儿血液和粪便进行常规检测,采用免疫金层析技术检测粪便标本的轮状病毒,实时荧光定量PCR(RT‐PCR)检测粪便标本轮状病毒、星状病毒、腺病毒及诺如病毒的表达水平,对结果采用SPSS16.0软件进行统计分析。结果124例腹泻患儿中免疫金层析技术和 RT‐PCR检测轮状病毒阳性率分别为37.9%和46.0%;RT‐PCR检测星状病毒、腺病毒及诺如病毒感染率分别为41.10%、19.40%和15.32%;重叠感染91例,其中轮状病毒与星状病毒重叠感染28例最为常见;急性胃肠炎患儿病毒感染率明显高于胃肠功能紊乱患儿(P<0.05);病毒感染在1岁以下腹泻患儿更常见(P<0.05),病毒感染腹泻患儿粪便性状常见水样;胃肠功能紊乱患儿血液C‐反应蛋白(CRP)>10、白细胞(WBC)>10×109/L和粪便WBC阳性比例均明显高于急性胃肠炎患儿(P<0.05)。结论 RT‐PCR可以提高腹泻患儿轮状病毒检出率,轮状病毒为腹泻患儿特别是<1岁患儿急性胃肠炎的主要病毒性因素,病毒性感染引起的腹泻以水样便更常见,胃肠功能紊乱患儿血像变化比急性胃肠炎患儿明显。%OBJECTIVE To investigate the relationship between viral infection and diarrhea‐related clinical parame‐ters in infants so as to provide reference for diagnose and prevention of this disease .METHODS Blood and feces samples were collected for routine examination from 124 diarrhea children less than 5 years of age .Test of rotavir‐us (RVs) in feces samples was carried out by immuno‐gold chromatography and the expression levels of four virus (rotavirus ,astrovirus ,adenovirus ,norovirus) in the feces samples were detected by RT‐PCR .The results were

  1. 复发性口腔溃疡中医分型与临床因素的相关性研究%Relationship between TCM Syndrome Types and Clinical Factors in Patients with Recurrent Oral Ulcer

    Institute of Scientific and Technical Information of China (English)

    胡建东; 孙靖; 薛鸾; 王丹; 李国陵; 朴雪梅; 吴香香

    2012-01-01

    Objective: To analyze the relationship between three TCM syndromes of recurrent oral ulcers with clinical factors such as eating habits,sleep quality, constipation, serum immunoglobulin,serum complement,serum iron. Methods: According to TCM syndrome differentiation, fifty patients with recurrent oral ulcers were assigned to three groups: syndrome of heat retention of heart and spleen, syndrome of hyperactivity of fire due to yin deficiency, and syndrome of deficiency of both qi and blood. Each patient was required to fulfill a questionnaire about eating habits,sleep quality and constipation. Meanwhile, blood test such as serum immunoglobulin, serum complement, the serum iron was conducted in all the subjects. Results:The course of the disease in patients with recurrent oral ulcers in the syndrome of deficiency of both qi and blood group was significantly longer than that the other two groups(P <0. 05) ;the serum levels of IgA in syndrome of heat retention of heart and spleen group were higher than those in syndrome of hyperactivity of fire due to yin deficiency group ( P < 0.05 ) , and syndrome of deficiency of both qi and blood group ( P < 0. 05 ) ; the serum complement - 3 ( C3 ) levels in syndrome of heat retention of heart and spleen group were notably lower than that in syndrome of deficiency of both qi and blood group(P <0.05) ;the serum iron levels in syndrome of deficiency of both qi and blood group Were significantly lower than that in syndrome of heat retention of heart and spleen group ( P < 0. 05 ) ; there were more eating disorder patients in syndrome of heat retention of heart and spleen group and syndrome of hyperactivity of fire due to yin deficiency group than syndrome of deficiency of both qi and blood group (P <0. 05) ;there were more constipation patients in syn-drome of heat retention of heart and spleen group than syndrome of hyperactivity of fire due to yin deficiency group-and syndrome of deficiency of both qi and blood group( P < 0

  2. The therapeutic relationship after psychiatric admission.

    LENUS (Irish Health Repository)

    Roche, Eric

    2014-03-01

    The therapeutic relationship is one of the most central and important factors in the treatment of mental health disorders. A better therapeutic relationship is associated with service engagement, medication adherence, and satisfaction with services. This study aimed to compare the demographic and clinical factors associated with the therapeutic relationship in voluntarily and involuntarily admitted psychiatric service users. We found that individuals who had been admitted involuntarily, who had a diagnosis of a psychotic disorder, and who reported higher levels of perceived pressures on admission were more likely to have a poorer therapeutic relationship with their consultant psychiatrist. Greater levels of insight and treatment satisfaction, together with higher levels of procedural justice experienced on admission, were associated with a better therapeutic relationship. We found that the level of perceived coercion on admission was not related to the therapeutic relationship. Targeted interventions to improve the therapeutic relationship, particularly for involuntarily admitted service users, are discussed.

  3. Clinical Characteristics and Features of Frequent Idiopathic Ventricular Premature Complexes in the Korean Population

    OpenAIRE

    Hwang, Jin Kyung; Park, Seung-Jung; On, Young Keun; Kim, June Soo; Park, Kyoung-Min

    2015-01-01

    Background and Objectives Frequent ventricular premature complexes (VPCs) increase the risk of cardiomyopathy (CMP). However, most data regarding VPCs have been obtained from Western population and in-hospital patient-based studies. The objective of this study was to define the clinical characteristics and features of idiopathic VPCs in the Korean population. Subjects and Methods We investigated subjects undergoing transthoracic echocardiography and documented VPC burdens >1% by Holter monito...

  4. Clinical Research and Clinical Trials

    Science.gov (United States)

    ... Meetings, Conferences & Events Partnering & Donating to the NICHD Staff Directory ... Clinical Research Skip sharing on social media links Share this: Page Content Clinical research is research that directly involves a ...

  5. Ancestral Relationships Using Metafounders

    DEFF Research Database (Denmark)

    Legarra, Andres; Christensen, Ole Fredslund; Vitezica, Zulma G;

    2015-01-01

    Recent use of genomic (marker-based) relationships shows that relationships exist within and across base population (breeds or lines). However, current treatment of pedigree relationships is unable to consider relationships within or across base populations, although such relationships must exist...

  6. The Relationship of Neurocognition and Negative Symptoms to Social and Role Functioning Over Time in Individuals at Clinical High Risk in the First Phase of the North American Prodrome Longitudinal Study

    OpenAIRE

    Meyer, Eric C.; Carrión, Ricardo E.; Cornblatt, Barbara A.; Addington, Jean; Cadenhead, Kristin S.; Cannon, Tyrone D.; McGlashan, Thomas H; Perkins, Diana O.; Ming T. Tsuang; Walker, Elaine F.; Woods, Scott W.; Heinssen, Robert; Seidman, Larry J.

    2014-01-01

    Objectives: Impaired social, role, and neurocognitive functioning are preillness characteristics of people who later develop psychosis. In people with schizophrenia, neurocognition and negative symptoms are associated with functional impairment. We examined the relative contributions of neurocognition and symptoms to social and role functioning over time in clinically high-risk (CHR) individuals and determined if negative symptoms mediated the influence of cognition on functioning. Methods: S...

  7. Development of a Weight Loss Mobile App Linked With an Accelerometer for Use in the Clinic: Usability, Acceptability, and Early Testing of its Impact on the Patient-Doctor Relationship

    OpenAIRE

    Choo, Seryung; Kim, Ju Young; Jung, Se Young; Kim, Sarah; Kim, Jeong Eun; Han, Jong Soo; Kim, Sohye; Kim, Jeong Hyun; Kim, Jeehye; Kim, Yongseok; Kim, Dongouk; Steinhubl, Steven

    2016-01-01

    Background Although complications of obesity are well acknowledged and managed by clinicians, management of obesity itself is often difficult, which leads to its underdiagnosis and undertreatment in hospital settings. However, tools that could improve the management of obesity, including self-monitoring, engagement with a social network, and open channels of communication between the patient and doctor, are limited in a clinic-based setting. Objective The objective of our study was to evaluat...

  8. RELATIONSHIPS AMONGST SELF-COMPASSION, SELF-ESTEEM AND SCHIZOTYPY

    OpenAIRE

    Marshall, Nicola

    2014-01-01

    Aims and Objectives The primary aim of the research was to investigate the nature of the relationships between self-compassion, self-esteem and schizotypy using a non-clinical sample. A secondary aim was to investigate the mechanisms which help to explain any relationships found. In utilising a non-clinical sample the study aimed to determine whether relationships exist between the variables prior to the onset of psychosis within a continuum approach to schizotypy. A final objective was to...

  9. 临床心灵关怀对住院肿瘤患者满意度及医患关系的影响%Effect of Clinical Spiritual Care on Patient Satisfaction and Doctor-patient Relationship in Tumor Inpatients

    Institute of Scientific and Technical Information of China (English)

    梁英; 谌永毅; 汤新辉; 徐慧兰; 陈继萍; 陈武朝

    2012-01-01

    目的 探讨临床心灵关怀对住院肿瘤患者满意度及医患关系的影响. 方法 本次调查研究的301名住院肿瘤患者根据是否接受过临床心灵关怀将其分为对照组(未接受临床心灵关怀)167例和观察组(接受过临床心灵关怀)134例.对照组给予常规护理,观察组在常规护理基础上进行心灵关怀护理,并采用住院患者满意度量表及自编医患关系评价问卷对两组患者进行问卷调查. 结果 观察组的就医满意度和对医患关系积极评价的比例明显高于对照组(P<0.05),观察组对医生的满意度为95.2%,对照组对医生的满意度为85.8%;观察组认为医患关系和谐的比例为80.8%,对照组为67.9%. 结论 心灵关怀能提高住院肿瘤患者的就医满意度,对构建和谐医患关系及促进患者早日康复有积极作用.%Objective To explore the influence of clinical spiritual care on patient satisfaction and doctor - patient relationship among tumor inpatients. Methods Three hundred and one inpatients with tumor were divided into control group (without clinical spiritual care, n= 167) and observation group (with clinical spiritual care, n= 134). The patients of control group were given routine nursing care after surgery, while the patients of observation group received clinical spiritual care on the basis of conventional care. The inpatient satisfaction questionnaires and self - designed doctor - patient relationship evaluation questionnaires were used to survey the patients in both groups. Results The degree of patient satisfaction and the proportion of positive evaluation on doctor - patient relationship in observation group were significantly higher than those in control group (P < 0.05 ). The patient satisfaction rates of observation group and control group were 95.2 % and 85.8 % , respectively. The proportions of considering harmonious doctor - patient relationship in observation group and control group were 80.8

  10. 跖腱膜炎与功能性腓肠肌挛缩关系的临床观察%Clinical research of the relationship between plantar fasciitis and gastrocnemius contracture

    Institute of Scientific and Technical Information of China (English)

    王海有; 张建中; 金合

    2012-01-01

    目的 研究跖腱膜炎与腓肠肌挛缩的关系.方法 对2010年9月~2010年1 1月足踝外科门诊收治的20人跖腱膜炎患者和31人正常足进行对比研究.结果 29足跖腱膜炎中16例(55.2%)合并腓肠肌挛缩.62正常足中 11例(17.7%)合并腓肠肌挛缩.结论 跖腱膜炎与腓肠肌挛缩关系密切,跖腱膜炎的患者多伴有腓肠肌挛缩.%Objective To study the relationship between plantar fasciitis and gastrocnemius contracture. Methods 20 outpatients with plantar fasciitis were compared with 31 normal people during Sep to Nov 2010 in Foot and ankle surgery department of Tongren hospital. Results 16 of 29 feet with plantar fasciitis ( 55.2% )had gastrocnemius contracture compared with 11 of 62 normal feet ( 17.7% ). Conclusion There is a close relationship between plantar fasciitis and gastrocnemius contracture. A plantar fasciitis patient is more likely to suffer gastorcnemius contracture.

  11. Study on the Clinical Relationship between Blood Glucose, Glycated Hemoglobin Level and Acute Cerebral Infarction%血糖、糖化血红蛋白水平与急性脑梗死临床关系的探讨

    Institute of Scientific and Technical Information of China (English)

    袁勇

    2012-01-01

      Objective To investigate acute patient of brain infarct blood sugar competence and clinical relation. Methods Empty stomach blood sugar level when admitting to hospital divide into normal blood sugar group,high blood sugar group, at random according to patient, Before treating, after treating,flawed or damaged to go on and give a mark to nervous system,Observe blood sugar, glycosylated hemoglobin have illness coming on the total mark and clinical relation. Results Acute brain infarct blood sugar level high,and have illness coming on and flawed or damaged to give a mark either high nervous system of patient,the worse its clinical curative effect is. Conclusion High bloods sugars accompany high glycosylated hemoglobin increase acute brain nervous system of infarct damage especially with have illness coming on. Lower candy treatment may improve acute brain clinical curative effect of infarct effectively,Prevent and treat high blood sugar to prevent brain infarct effective measure one of actively.%  目的探讨血糖、糖化血红蛋白水平与急性脑梗死患者的临床关系。方法对收治的78例急性脑梗死患者的临床资料进行回顾性分析,根据入院时空腹血糖水平分为正常血糖组、高血糖组,病情好转后对所有患者进行神经系统缺损评分,观察血糖、糖化血红蛋白和临床的关系。结果急性脑梗死患者高血糖组与正常血糖组相比,其神经系统缺损评分高,总有效率低。结论高血糖尤其伴高糖化血红蛋白会增加急性脑梗死神经系统损伤,预后差。故积极预防和治疗高血糖是预防脑梗死的有力措施之一。

  12. The relationship between adherence to clinic appointments and year-one mortality for newly enrolled HIV infected patients at a regional referral hospital in Western Kenya, January 2011-December 2012.

    Science.gov (United States)

    Kimeu, Muthusi; Burmen, Barbara; Audi, Beryl; Adega, Anne; Owuor, Karen; Arodi, Susan; Bii, Dennis; Zielinski-Gutiérrez, Emily

    2016-01-01

    This retrospective cohort analysis was conducted to describe the association between adherence to clinic appointments and mortality, one year after enrollment into HIV care. We examined appointment-adherence for newly enrolled patients between January 2011 and December 2012 at a regional referral hospital in western Kenya. The outcomes of interest were patient default, risk factors for repeat default, and year-one risk of death. Of 582 enrolled patients, 258 (44%) were defaulters. GEE revealed that once having been defaulters, patients were significantly more likely to repeatedly default (OR 1.4; 95% CI 1.12-1.77), especially the unemployed (OR 1.43; 95% CI 1.07-1.91), smokers (OR 2.22; 95% CI 1.31-3.76), and those with no known disclosure (OR 2.17; 95% CI 1.42-3.3). Nineteen patients (3%) died during the follow-up period. Cox proportional hazards revealed that the risk of death was significantly higher among defaulters (HR 3.12; 95% CI 1.2-8.0) and increased proportionally to the rate of patient default; HR was 4.05 (95% CI1.38-11.81) and 4.98 (95% CI 1.45-17.09) for a cumulative of 4-60 and ≥60 days elapsed between all scheduled and actual clinic appointment dates, respectively. Risk factors for repeat default suggest a need to deliver targeted adherence programs.

  13. 幽门螺杆菌与肝源性胃病的临床分析%Clinical analysis of the relationship among Helicobacter pylori and portal hypertensive gastropathy

    Institute of Scientific and Technical Information of China (English)

    杜建新; 侯激流; 蒋锦华; 芦红

    2012-01-01

    Objective To explore the relationship between helicobacter pylori(Hp) and liver cirrhosis erupting stomach and duodenum pathological change. Methods 264 patients with liver cirrhosis were detected Hp infection. The relationship of Hp infection, liver source ulcer and portal hypertensive gastropathy (PHG) were analyzed. Results Percentage of Hp infection and the chronic gastritis (CG) of liver cirrhosis patient was not different. Hp infection rate of Liver cirrhotic with duodenal ulcer was higher than that without duodenal ulcer. Conclusion Hp in Cirrhosis patient is in close realation with DU. but there is not remarkable relation with PHG and GU.%目的 探讨幽门螺杆菌(Hp)与肝硬化并发胃及十二指肠病变的关系.方法 对269例肝硬化患者Hp感染进行检测,并分析Hp感染与门脉高压性胃病(PHG)及肝源性溃疡的关系.结果 肝硬化患者Hp感染率与慢性胃炎(CG)接近;Hp感染率在肝硬化有、无PHG及轻、重型PHG组间无显著差异(P>0.05);肝硬化伴十二指溃疡(DU)组HP感染率高于不伴溃疡组(P<0.05)而与DU对照组接近(P>0.05);肝硬化伴胃溃疡(GU)组Hp感染率与不伴溃疡组无显著差异(P>0.05),但显著低于GU对照组(P<0.05).结论 肝硬化患者Hp与DU关系密切,而与PHG及GU无显著关系.

  14. A Relationship Strategy Perspective on Relationship Portfolios

    DEFF Research Database (Denmark)

    Ritter, Thomas; Andersen, Henrik

    2014-01-01

    The paper develops a three-dimensional portfolio model for business relationships which distinguishes among six different categories. Based on assessments of customer profitability, customer commitment, and growth potential, the positioning of a given customer relationship in the portfolio allows...... managers to determine appropriate customer relationship strategies and appropriate performance indicators. Results from applying the portfolio model are reported and managerial implications and future research are discussed....

  15. Personality and Sibling Relationships.

    Science.gov (United States)

    Furman, Wyndol; Lanthier, Richard P.

    1996-01-01

    This study examined the role personality variables play in sibling relationships. It proposed that the characteristics of sibling relationships are influenced by: family constellation variables such as birth order, gender, and age spacing; parent-child relationships including quality of relationship and parent management of siblings; and the…

  16. 砷暴露人群指甲砷硒含量与砷中毒临床分度关系分析%The analysis of relationships between nail arsenic, selenium and the clinical type for arsenic exposed population

    Institute of Scientific and Technical Information of China (English)

    郭志伟; 武克恭; 李艳红; Timothy J wade; Judy Mumford; 夏雅娟

    2011-01-01

    Objective To study the relevance of nail arsenic, selenium concentrations and clinical type for arsenic exposed residents in drinking - water. Methods Water and nail samples were collected and physical examination was done of 599 residents exposed As via drinking water in Hangjinhouqi and Wuyuan county of Bayannaoer city in Inner Mongolia. Water As was analyzed by inductively coupled plasma mass spectrometry(ICPMS); Nail samples were analyzed for As and Se content by instrumental neutron activation analysis ( INAA ). Results The water As concentrations was positively associated with nail As concentrations ( r = 0. 896, P <0.01 ), but was inversely associated with nail Se concentrations ( r = -0. 322, P <0.01 ). The nail As concentrations was also negatively associated with nail Se concentrations ( r = - 0. 355, P <0. 01 ). The nail Se was positively associated with clinical type of arsenic exposed residents ( r = 0. 225, P < 0. 01 ). There are signifi cant differences for clinical type among four groups of As exposed people ( P < 0. 01 ). Conclusions The nail As concentrations of arsenic exposed population is negatively associated with the nail Se concentrations, suggesting that there are antagonistic effect in the human body between As and Se. In addition, the nail As concentrations is positively associated with clinical type of arsenic exposed residents,indicating it's importance to the diagnosis of endemic arsenism.%目的 研究砷暴露地区居民饮用水砷浓度与指甲砷、硒含量及砷暴露人群临床分度之间的关系.方法 对内蒙古巴彦淖尔市杭锦后旗和五原县不同水砷浓度暴露的599位居民进行指甲采样和临床砷中毒检查.利用电感耦合等离子质谱仪(ICPMS)测定水砷浓度,中子活化分析法(INAA)测定指甲内砷和硒的含量.结果 水砷与指甲砷含量呈正相关(r=0.896,P<0.01),水砷与指甲硒含量呈负相关(r=-0.322,P<0.01),指甲砷与指

  17. The relationship between adherence to clinic appointments and year-one mortality for newly enrolled HIV infected patients at a regional referral hospital in Western Kenya, January 2011–December 2012

    Science.gov (United States)

    Kimeu, Muthusi; Burmen, Barbara; Audi, Beryl; Adega, Anne; Owuor, Karen; Arodi, Susan; Bii, Dennis; Zielinski-Gutiérrez, Emily

    2016-01-01

    This retrospective cohort analysis was conducted to describe the association between adherence to clinic appointments and mortality, one year after enrollment into HIV care. We examined appointment-adherence for newly enrolled patients between January 2011 and December 2012 at a regional referral hospital in western Kenya. The outcomes of interest were patient default, risk factors for repeat default, and year-one risk of death. Of 582 enrolled patients, 258 (44%) were defaulters. GEE revealed that once having been defaulters, patients were significantly more likely to repeatedly default (OR 1.4; 95% CI 1.12–1.77), especially the unemployed (OR 1.43; 95% CI 1.07–1.91), smokers (OR 2.22; 95% CI 1.31–3.76), and those with no known disclosure (OR 2.17; 95% CI 1.42–3.3). Nineteen patients (3%) died during the follow-up period. Cox proportional hazards revealed that the risk of death was significantly higher among defaulters (HR 3.12; 95% CI 1.2–8.0) and increased proportionally to the rate of patient default; HR was 4.05 (95% CI1.38–11.81) and 4.98 (95% CI 1.45–17.09) for a cumulative of 4–60 and ≥60 days elapsed between all scheduled and actual clinic appointment dates, respectively. Risk factors for repeat default suggest a need to deliver targeted adherence programs. PMID:26572059

  18. Thyroid-Stimulating Hormone, Triiodotyronine and Thyroxine Concentrations and Their Relationship with Metabolic Parameters, Anthropometric Variables and Body Composition in Premenopausal Euthyroid Obese Women

    OpenAIRE

    Mahdieh Abbasalizad Farhangi; Mohammadreza Eshraghian; Seyyed Ali Keshavar; Ali Akbar Saboor-Yaraghi

    2015-01-01

    Purpose: This study was performed to evaluate the potential relationships of thyroid hormones, metabolic parameters, and anthropometric variables with body composition in premenopausal women. Material and Method: A total of 84 women with a mean age of 35.12±8.11 years were investigated. Subjects with a history of diabetes, hyperthyroidism and hypothyroidism, chronic liver, and renal disease were excluded from the study. In all subjects, anthropometric parameters were evaluated and body com...

  19. Clinical Research

    DEFF Research Database (Denmark)

    Christensen, Irene

    2016-01-01

    for years to come. This paper seeks to provide insights into ramp-up management studies through providing an agenda for conducting collaborative clinical research and extend this area by proposing how clinical research could be designed and executed in the Ramp- up management setting.......This paper is about the logic of problem solving and the production of scientific knowledge through the utilisation of clinical research perspective. Ramp-up effectiveness, productivity, efficiency and organizational excellence are topics that continue to engage research and will continue doing so...

  20. Clinical research on relevant relationship between cervical vertigo and instability and treatment based on differentiation in TCM%中药鼻饲防治心肺复苏后并发急性肾损伤体会

    Institute of Scientific and Technical Information of China (English)

    周燕红; 金晓玲; 朱丽娟

    2014-01-01

    目的:探讨中医药对心肺复苏后急性肾损伤的防治作用。方法:选取符合条件的心肺复苏后自主循环恢复的患者共23例,在常规进一步治疗的基础上,予中药汤剂鼻饲。结果:23例观察病例,有14例死亡,死亡率为60.9%,有6例发生AKI ,发生率为26.1%。结论:中药在防治心肺复苏后并发急性肾损伤可能有一定积极的意义。%Objective: To investigate the treatment based on differentiation in TCM through studying the relevant relationship between cervical vertigo and instability. Methods: 50 cases with cervical vertigo from January 2012 to January 2014 were selected, 31 cases of male patients and 19 cases of female patients. Age range was between 30-75, an average of 60.3 years old. All 50 cases of patients were analyzed on the the relevant relationship between cervical vertigo and instability and TCM differentiation in order to make sure the cervical instability and incidence of this disease. Patients were divided into a control group and a research group, the characteristic of the disease as well as the differences of classification in TCM were analyzed. Results: 30 patients in the control group had no cervical instability, the incidence was 0%, 50 cases of patients in the research group, 36 cases with cervical instability, the incidence was 72%. Neck 2-7 vertebral backup Angle of(6.75 ± 0.89). Conclusion:Cervical vertigo patients of cervical vertebral rear within 7 ° will not produce the prototype of vertigo. Treatment based on differentiation in TCM has a great effect.

  1. 精神分裂症智能损害与脑萎缩的关系探讨%A Clinical Study on Relationship between Intelligence Impairment and Brain Atrophy in Schixophrenia

    Institute of Scientific and Technical Information of China (English)

    高镇松; 林和文

    2003-01-01

    Objective To explore the relationship between intelligence impairment and brain atro-phy in schixophrenia. Methods 34 cases with schizophrenia were tested intelligence with WAIS-RC andwere examined brain CT. Then, according to CT results, all the subjects were classified into two grups-the brain atrophy group with 28 patients (about 82%) and the non-brain atrophy group with 6 cases(about 18%). The intelligence of the two groups were compared with each other with the control ofnorms. At the same time, the conditions of brain atrophy in different levels were analyzed. Results Thebrain atrophy group showed obviously more intelligence impairment. The lower the intelligent level was ,the higher the incidence of brain atrophy showed, and the severer and broader the brain atrophy was suchas ventricle broadenness, fissure widenness, sulci deeepenness, even the whole brain atrophy.Conclusions There was close relationship between intelligence impairment and brain atrophy in schixo-phrenia. This suggested that the schizophrenics with intelligence impairment existed the basis of brainorganic impairment.%目的探讨精神分裂症智能损害与脑萎缩的关系.方法应用WAIS-RC对34例精神分裂症患者进行智力测验,然后按CT结果分为脑萎缩组28例(82%)和非脑萎缩组6例(18%),分别进行智力测验比较并与常模对照,同时分析不同智力水平脑萎缩的情况.结果脑萎缩组的智能损害更明显、智力水平越低、脑萎缩的发生率越高、程度越重、分布越广(如脑室扩大、脑裂增宽、脑沟加深、甚至全脑萎缩).结论精神分裂症智能损害与脑萎缩关系密切,提示精神分裂症智能损害者存在脑器质损害基础.

  2. The clinical method and the scientific method

    Directory of Open Access Journals (Sweden)

    José Arteaga Herrera

    2010-12-01

    Full Text Available This paper is the chapter dedicated to the scientific method and the clinical method in the authors’ Handbook “Teaching of Clinics”. Philosophycal principles of the scientific method and its stages are presented as well as the clinical method as a scientific one and its stages. A relationship between the clinical method and the medical record is established, the role of technology in the clinical method is stated and the most frequent mistakes when applying it in clinical practice are provided. Finally, the teaching of the clinical method and the appropriate settings to do it are discussed.

  3. Development of Adolescent Relationships

    OpenAIRE

    Goede, I.H.A. de

    2009-01-01

    This dissertation on “Development of Adolescent Relationships” addresses relationships with parents, friends, and romantic partners in adolescence from a developmental perspective. By studying both parent-adolescent relationships and peer relationships at the same time, as well as interrelations between these types of relationships, this dissertation provides more information on the processes taking place in relationships during adolescence. Findings indicate that parent-adolescent relationsh...

  4. Clinical photography.

    Science.gov (United States)

    Jakowenko, Janelle

    2009-01-01

    Digital cameras, when used correctly, can provide the basis for telemedicine services. The increasing sophistication of digital cameras, combined with the improved speed and availability of the Internet, make them an instrument that every health-care professional should be familiar with. Taking satisfactory images of patients requires clinical photography skills. Photographing charts, monitors, X-ray films and specimens also requires expertise. Image capture using digital cameras is often done with insufficient attention, which can lead to inaccurate study results. The procedures in clinical photography should not vary from camera to camera, or from country to country. Taking a photograph should be a standardised process. There are seven main scenarios in clinical photography and health professionals who use cameras should be familiar with all of them. Obtaining informed consent prior to photography should be a normal part of the clinical photography routine.

  5. Relationship between quality of life and clinical status in patients with gastrointestinal cancer Relación entre calidad de vida y estadio clínico en pacientes con cáncer gastrointestinal

    Directory of Open Access Journals (Sweden)

    Ricardo Sánchez

    2012-12-01

    Full Text Available Background: previous studies with patients having cancer have shown that quality of life scores depend on the clinical stage of the disease (the more advanced the disease, the worst quality of life. Methods: in a prospective study we studied 317 patients with gastric or colorectal cancer attending the Instituto Nacional de Cancerología between 2010 and 2011; the patients completed the EORTC QLQ-C30 before receiving treatment. This instrument measures quality of life in 15 domains. Scores of each domain were compared according to tumor stage. Differential Item Functioning was measured across neoplasm staging and tumor localization. Results: 145 patients (45.7% were diagnosed with colorectal cancer. According to clinical staging, differences in quality of life scores were observed in 4 of 15 domains (physical and social functioning, anorexia. Most of the differences in quality of life domains depended on tumor localization (patients with colorectal cancer had the highest scores in quality of life and sex (women reported better scores. These differences seemed to be independent of item properties. The construct was more adequately measured with items that explore the construct using a general approach. Conclusion: in this group of patients with colorectal and gastric cancer quality of life scores were more related with tumor localization than with clinical stage.Introducción: la calidad de vida de pacientes con cáncer varía según el estadio clínico de la enfermedad, siendo peor en estadios avanzados. Métodos: estudio prospectivo en el que se evaluaron 317 pacientes con cáncer colorrectal o gástrico que asistieron al Instituto Nacional de Cancerología durante los años 2010 y 2011 y que no habían iniciado tratamiento. Se utilizó el cuestionario EORTC QLQ C-30, un instrumento que mide calidad de vida en 15 dominios. Se compararon las puntuaciones para cada dominio según el estadio tumoral. Adicionalmente se realizó un análisis de

  6. Study on relationship between employment pressure and professional self-concept of nursing students in clinical practice%临床实习护生就业压力与专业自我概念的关系研究

    Institute of Scientific and Technical Information of China (English)

    吕芳菲; 李春芳

    2011-01-01

    Objective:To investigate the employment pressure and professional self - concept of nursing students in clinical practice, and know about the correlation between them, so as to provide theoretical evidences for the employment guidance for nursing students. Methods: A total of 171 nursing students were investigated by using the self - made general situation questionnaire, college students employment pressure questionnaire and nursing professional self - concept scale. Results:The total score of employment pressure of nursing students in the clinical internship was(2. 75 + 0. 67) ,6 factors scores from high to low by turns respectively were Lack of job search assistance, employment competition environment, employment psychological expectations, contradiction between professional supply and demand, professional quality evaluation and self - awareness and positioning; in the general information, the family economic status and learning achievement were the major factors influencing the employment pressure; the professional self -concept score of nursing students was (2. 83 + 0. 46), wherein the flexibility score was the highest, satisfaction score was the lowest; in the general information, the learning achievement was the main factor affecting the professional self - concept; nursing students' employment pressure level was negatively correlated with professional self - concept(Pclinical practical nursing students may influence the employment stress, hospitals should actively cultivate students good professional self - concept, and take corresponding measures to alleviate the employment pressure of nursing students, so as to help them employment smoothly.%[目的]调查实习护生的就业压力与专业自我概念水平,了解二者的相关性,为护生的就业指导提供理论依据.[方法]采用自制一般情况调查表、大学生就业压力问卷和护理专业自我概念量表对171名

  7. Clinical supervision.

    Science.gov (United States)

    Goorapah, D

    1997-05-01

    The introduction of clinical supervision to a wider sphere of nursing is being considered from a professional and organizational point of view. Positive views are being expressed about adopting this concept, although there are indications to suggest that there are also strong reservations. This paper examines the potential for its success amidst the scepticism that exists. One important question raised is whether clinical supervision will replace or run alongside other support systems.

  8. Ethical dilemmas in clinical genetics.

    OpenAIRE

    Young, I D

    1984-01-01

    This paper discusses the results of a survey of medical and paramedical opinion relating to various difficult ethical issues in clinical genetics. These include the confidentiality of the doctor-patient relationship, prenatal diagnosis and termination, and Huntington's chorea. It is suggested that this method provides a useful means of assessing what is ethically acceptable in contemporary society.

  9. Clinical Analysis of the Relationship between Balanced Chromosomal Translocation and Abnormal Pregnancy%染色体平衡易位携带者引起不良孕育的临床分析

    Institute of Scientific and Technical Information of China (English)

    沈红霞; 尹坤

    2015-01-01

    目的:通过对2450例有自然流产、死胎、畸胎、少精等不良孕育史的患者的染色体结果调查,探讨平衡易位与不良孕育史的关系。方法:取外周血进行淋巴细胞培养,染色体G显带分析。结果:2450例患者中检出染色体平衡易位22例(罗伯逊易位3例),占0.90%。患者表现为自然流产、死胎、畸形儿、少精等不良孕育史。结论:染色体平衡易位是导致患者不良孕育史的重要原因之一。对这类人群进行遗传优生和产前诊断及辅助生殖指导等有针对性的检查和临床干预是非常必要的。%Objective: To investigate 2 450 patients' chromosomes with a history of abnormal pregnancy such as spontaneous abortion, fetal death, teratism, and oligospermia and to explore the relationship between balanced chromosomal translocation and abnormal pregnancy. Methods:Chromosomal analysis was made by peripheral lymphocytes culture and G-banding. Results:22 cases of balanced translocation were discovered(3 cases of robertsonian translocation)accounting for 0.90%. Spontaneous abortion, fetal death, teratism, and oligospermia were main manifestations of abnormal pregnancy. Conclusion:Balanced chromosomal translocation was a major reason for abnormal pregnancy. Examination of heredity and prepotency, prenatal diagnosis, guidance on assisted production were necessary for balanced chromosomal translocation carriers.

  10. Willis环变异与颅内动脉瘤关系的临床探讨%Clinical study of the relationship between Willis arterial loop variation and intracranial aneurysms

    Institute of Scientific and Technical Information of China (English)

    杨帆

    2016-01-01

    目的 探究CT血管成像技术显示Willis环的变异情况与颅内动脉瘤发生的关系.方法 分析2014年1月至2014年12月四川医科大学附属第一医院收治的144例颅内动脉瘤患者的数字血管造影资料,根据所有患者动脉瘤所在部位,将患者分为前交通动脉瘤组和后交通动脉瘤组,比较两组患者的性别、年龄、颅内动脉瘤瘤体的长径情况,探讨颅内动脉瘤与Willis环分型的关系.并与手术结果比较,分析其敏感性与特异性.结果 通过CT血管成像共检出144例颅内动脉瘤患者,其中前交通动脉瘤患者68例,后交通动脉瘤患者76例,两组患者在性别分布、年龄分布、瘤体长径差异无统计学意义(P>0.05);前交通动脉瘤组中,A1段纤细或缺如率达79.41%,而后交通动脉瘤组中A1段纤细或缺如率仅为52.63%,两组比较差异有统计学意义(P<0.05);前交通动脉瘤组中双侧胚胎型大脑后动脉率63.24%,后交通动脉瘤组中右侧或左侧(单侧)胚胎型大脑后动脉率59.21%.两组患者CT血管显像(CTA)检查结果敏感性与特异性差异无统计学意义(P>0.05).结论 CT血管成像能够较为准确的诊断出颅内动脉瘤;前交通动脉瘤的发生与A1段纤细、缺如以及双侧胚胎型大脑后动脉关系较为紧密,而后交通动脉瘤的发生与单侧胚胎型大脑后动脉的关系更为密切.%Objective To explore the relationship between the changes of the cerebral arterial circle of Willis and the occurrence of intracranial aneurysms in the diagnosis of digital angiography.Methods From December 2014 to January 2014,144 cases of intracranial aneurysms were treated in the First Affiliated Hospital of Luzhou Medical University.According to the location of the aneurysm of all patients,the patients were divided into the anterior communicating artery and the posterior communicating artery aneurysms.The relationship between two groups of patients was compared by the

  11. Influence of Nonverbal Behavior on Doctor-Patient Relationship in Clinical Activities——Based on the Survey Data of Five Top-Class Hospitals in X City%诊疗中非言语行为对医患关系的影响——基于某市5所三甲医院的调查研究

    Institute of Scientific and Technical Information of China (English)

    孙咏莉; 王晓燕; 梁立智; 关丽征; 宋晓霞; 焦峰

    2011-01-01

    There is a significant difference in expectation of speech tone, gestures, distance, eye contact, facial expressions, standing and sitting posture in clinical activities between doctors and patients, that was shown in this investigation. And these unmatched non - verbal elements to some extent influenced the construction of harmonious Doctor - Patient Relationship.%本次调查发现,在诊疗活动中,医患双方对医务人员讲话的语气、手势、问诊距离、眼神、表情、职业坐姿和职业站姿等非言语行为要素的期待存在明显差异,这些不匹配的非言语行为要素在一定程度上影响了和谐医患关系的构建.

  12. The relationship between the Bispectral Index (BIS) and the Observer Alertness of Sedation Scale (OASS) scores during propofol sedation with and without ketamine: a randomized, double blinded, placebo controlled clinical trial.

    Science.gov (United States)

    De Oliveira, Gildasio S; Kendall, Mark C; Marcus, R-Jay; McCarthy, Robert J

    2016-08-01

    Prior studies have examined the static effect of intravenous ketamine on the BIS Index for sedation but it remains unknown if the BIS Index is a reliable method to track sedation levels in the presence of ketamine. The major objective of the current investigation was to compare the BIS Vista Index ability to track varying depths of sedation as determined by OASS scores in a standardized anesthetic regimen with and without ketamine. The study was a randomized, double blinded clinical trial. Patients undergoing breast surgery under sedation with propofol were randomized to receive ketamine (1.5 μg kg min(-1)) or saline. Infusion data was used to estimate propofol plasma concentrations (Cp). The main outcome of interest was the correlation between the BIS Vista Index with the OASS score. Twenty subjects were recruited and fifteen completed the study. Four hundred fifty-five paired data points were included in the analysis. Model performance (Nagelkerke R(2)) of the multinomial logistic regression model was 0.57 with the c-statistic of 0.87 (95 % CI 0.82-0.91). Compared to awake the odds ratio for BIS values predicting moderate sedation in the saline/propofol group 1.19 (95 % CI 1.12-1.25) but only 1.06 (95 % CI 1.02-1.1) in the ketamine/propofol group (P = 0.001). There was no difference in the odds for BIS values to predict deep sedation between groups (P = 0.14). The BIS monitor can be used to monitor sedation level even when ketamine is used with propofol as part of the sedation regimen. However, ketamine reduces the value of the BIS in predicting moderate sedation levels. PMID:26219614

  13. 绞窄性肠梗阻手术时机与临床指标的相关性%Relationship between Operation Timing and Clinical Criteria in Intestinal Obstruction

    Institute of Scientific and Technical Information of China (English)

    郭科; 封光华; 贾忠

    2011-01-01

    Objective To investigate the reliable indicators of operation timing of strangulated intestinal obstruction. Methods A retrospective study of 65 patients with simple intestinal obstruction and 55 patients with strangulated intestinal obstruction was done.. All patients were confirmed by operation. Indicators including body temperature, pulse abdominal pain, abdominal distension, result of peritoneocentesis, leukocyte count, C-reactive protein, D-dimer, CT finding and shock were observed and recorded. Te relationship between the indicators and the operation timing of strangulated intestinal obstruction was analyzed with SPSS statistical analysis software package. Results In simple intestinal obstruction group, three patients (4.62%) met two of the above indicators and nobody met three or more of the above indicators. In strangulated intestinal obstruction group,twenty patients (36.36%) met two of the above indicators and twenty five (45.45%) patients met three or more of the above indicators, Conclusion Once a patient with intestinal obstruction meet two or more of the above indicators, he or she most likely has strangulated occurred, hence the patients should be treated carefully and operated in time.%目的:探讨绞窄性肠梗阻判断手术时机的临床可靠指标.方法:回顾性分析经手术证实的急性非绞窄性肠梗阻(65例)及绞窄性肠梗阻(55例)患者的相关临床资料,观察体温、脉搏、腹痛、腹胀、腹腔穿刺、白细胞计数、C-反应蛋白、D-二聚体、CT表现、休克情况等,并与手术时机之间的相关性进行分析.结果:急性非绞窄性肠梗阻患者符合相关指标中2项的3例(4.62%),绞窄性肠梗阻符合相关指标2项的20例(36.36%),3项及3项以上的25例(45.45%).结论:肠梗阻患者如符合相关指标中的2项以上,则提示该患者极有可能为绞窄性肠梗阻,应高度重视并积极手术.

  14. CT Study and Clinical Significance of Anatomical Relationship between Optic Nerve and Sphenoid Sinus%视神经与蝶窦解剖关系及其临床意义的CT研究

    Institute of Scientific and Technical Information of China (English)

    孙佳琦; 朱海涛; 石晓云; 徐金; 王冬青; 姜平; 宋慧慧; 罗香; 张铖; 朱习文; 李月峰; 赵晨晧; 顾丙新; 马丽

    2011-01-01

    目的:通过CT观察并探讨视神经与蝶窦关系的变化规律,为视神经管减压术提供依据.方法:随机选择鼻窦无明显异常的成人头部CT扫描350例,观察视神经隆凸的出现率,根据蝶窦内有无隆凸,将其分为视神经隆凸组和非隆凸组,各组随机选择30例进行蝶窦体积测量,比较两组之间体积的差异.在计算机上用Mimics软件勾画蝶窦、视神经等结构的轮廓,软件自动给出蝶窦的体积和三维重建图.结果:蝶窦腔内有视神经隆凸56例(16%),其中24侧的视神经直接裸露在蝶窦内,35例伴前床突气化.后者中有21侧气化的前床突腔隙与蝶窦腔融合,视神经游离于蝶窦腔内;19侧气化的前床突腔隙与后筛窦融合,视神经行走于筛窦内.无视神经隆凸组的蝶窦体积为(15.26±11.22)cm3,有视神经隆凸的蝶窦体积为(26.72±5.77)cm3.两组比较差异有统计学意义(P<0.05).通过蝶窦、视神经的三维立体重建模型的观察,其有48%的视神经主要与蝶窦相邻,有52%的视神经主要与后筛窦相邻.结论:视神经隆凸与蝶窦体积相关,体积越大,视神经隆凸的出现率就高,从而提示是否实施经蝶窦的视神经减压术等内镜手术蝶窦体积是其考虑的主要因素之一.部分受试者的视神经与蝶窦接触较少,如经蝶窦入路有可能难以寻找视神经.%Objective: To explore the variation rule of the relationship between the optic nerve( ON )and sphenoid sinuses( SS ) by computed tomography and provide the surgery basis for optic nerve canal decompression. Methods:350 CT scans of adult heads without nasal sinuses abnormity were randomly selected and incidence of optic nerve protrusion in the sphenoid sinus was observed . According to with or without protrusion , two groups were formed and 30 of each group were randomly selected . Volume of sphenoid sinus was measured and the volume between two groups were compared ,the outline of sphenoid sinus and

  15. 睑板腺功能障碍与血糖浓度及脂质代谢水平相关性研究%Clinical research of relationship between meibomian gland dysfunction and blood glucose concentration and lipid metabolism

    Institute of Scientific and Technical Information of China (English)

    李华; 乔丽萍; 王春娥; 王素莉; 沈继春; 赵季红; 陈慧鑫

    2016-01-01

    Objective To analyze the relationship between meibomian gland dysfunction and concentration of blood glucose and lipid metabolism.Methods A randomized and double-mask trial was conducted for 4 months duration.Eighty-four cases of diabetic patients (group A) and 35 controls without diabetic and with history of cardiovascular disease (group B),accrued from October 2014 to January 2015 were included.Group A was divided into group A1 and A2 according to whether with cardiovascular diseases,group A1 for diabetes with no cardiovascular disease; group A2 for diabetic combined cardiovascular disease.The relationship between meibomian gland dysfunction and concentration of blood glucose and lipid metabolism were analyzed.Results Meibomian gland dysfunction prevalence was 75% in diabetes patients.There were statistically significant difference between the groups A1 and group B,group A2 and group B,while no significant difference between the group A1 and group A2 on analysis of meibomian gland obstruction score.There were statistically significant between the group A2 and group B on analysis of quality of expressed meibum score,no significant difference among the other groups.In correlation analysis,the meibomian gland obstruction score was positively correlated with fasting glucose (P =0.006,rs =0.252),and the rest had no correlation.Conclusions The prevalence of meibomian gland dysfunction is up to 75% in diabetes patients,the concentration of fasting plasma glucose is a risk factor in diabetic patients with meibomian gland dysfunction development and adjustment of the concentration of fasting plasma glucose can help improvement of therapeutic effect in diabetic patients with meibomian gland dysfunction.%目的 探讨睑板腺功能障碍与血糖浓度及脂质代谢水平之间的相关性.方法 临床病例对照研究.收集2014年10月至2015年1月在辽宁医学院武警后勤学院附属医院的84例糖尿病患者为病例组(A组)(根据是

  16. Clinical research on the relationship between breast cancer and thyroid disorder%乳腺癌与甲状腺疾病相关性的临床研究

    Institute of Scientific and Technical Information of China (English)

    赵艳杰; 王睿斌; 宋雨光; 任军

    2013-01-01

    目的 探讨乳腺癌患者自身免疫与非自身免疫甲状腺疾病的发病情况.方法 选择100例乳腺癌手术患者,以同期相对应年龄无乳腺疾病及甲状腺疾病病史女性100名为对照组,通过临床检查、B型超声、甲状腺素及抗体水平检查、细针穿刺活组织检查等对比甲状腺疾病的发病情况.结果 乳腺癌患者抗甲状腺过氧化物酶抗体明显高于对照组[(104.56±21.54)U/ml比(22.16±4.65)U/m],P=0.030].乳腺癌组自身免疫与非自身免疫甲状腺疾病的发病率高于对照组[38 %(38/100)比17%(17/100),P=0.0009;26%(26/100)与9%(9/100),P=0.0016].结论 乳腺癌患者的自身免疫与非自身免疫甲状腺疾病的发病率高于非乳腺癌者.%Objective To investigate the incidence of autoimmune and nonautoimmune thyroid diseases in patients with breast cancer.Methods Clinical and ultrasound evaluation of thyroid gland,detection of serum thyroid hormone and related antibodies,and fine-needle aspiration of thyroid gland were performed in 100 breast cancer patients and 100 control individuals during the period from 2004 to 2008.Results The mean values of anti-thyroid peroxidase antibodies were significantly higher in breast cancer patients than that in control individuals [(104.56±21.54) U/ml vs (22.16±4.65) U/ml,(P=0.030)].The incidence rates of autoimmune and nonautoimmune thyroid diseases were higher in breast cancer patients than that in control individuals[38 % (38/100) vs 17 % (17/100),P=0.0009,26 % (26/100) vs 9 % (9/100),P =0.0016,respectively].Conclusion The results indicate an increased incidence of autoimmune and nonautoimmune thyroid diseases in breast cancer patients.

  17. Clinical analysis of the relationship between insight and psychiatric medication compliance%自知力与精神病患者服药依从性关系的临床分析

    Institute of Scientific and Technical Information of China (English)

    樊素琴; 邱松伟

    2015-01-01

    目的:探讨自知力与精神病患者服药依从性的关系.方法:2012 年 11 月-2014 年 11 月收治精神病患者 50例,随机分为试验组和对照组,每组 25 例,试验组在常规治疗的基础上实施自知力教育,对照组只给予常规治疗,治疗前后,采用简明精神病量表(BPRS)与自制力、治疗态度问卷(ITAQ)测试并评估.比较对照组与试验组的服药依从性变化、患者的自知力恢复情况与患者家属满意率.结果:治疗前试验组BPRS和ITAQ得分同对照组比较差异无统计学意义(P>0.05),治疗后,试验组BPRS得分明显小于对照组(P0.05). After treatment, BPRS score of the experimental group was significantly lower than that of control group(P<0.05);experimental group ITAQ scores were significantly greater than in the control group(P<0.05);medication compliance in the experimental group was significantly better than the control group(P<0.05);the experimental group patients satisfaction rate of 96% were better than those of the control group 76% ,and there was significant difference between the groups(P<0.05).Conclusion:The insight education can improve psychiatric patients insight,so as to improve the compliance of patients with psychiatric medication, promotion of family members of patients satisfaction rate,won a reputation for the hospital,so it is worth the clinical promotion.

  18. 高尿酸血症与急性脑梗死的关系临床研究%The Clinical Research of the Relationship between High Uric Acid Hematic Disease and Acute Cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    郭建军; 倪晓俊; 史丽; 刘就娣; 吴小燕; 魏伟民

    2015-01-01

    目的:探讨高尿酸血症与急性脑梗死发生、发展的相关性。方法:选取2013年9月-2014年9月期间本院诊治的120例急性脑梗死患者,根据空腹血清尿酸水平,将其分为高尿酸血症组(急性脑梗死伴高尿酸血症患者,40例)和正常尿酸组(血清尿酸水平正常的急性脑梗死患者,80例),根据1995年脑卒中临床神经功能缺损程度评分标准,观察和比较治疗前两组中重型、轻型神经功能缺损程度比率、伴发疾病发生率以及治疗后两组临床疗效。结果:治疗前高尿酸血症组中重型神经功能缺损发生率明显高于正常尿酸组,轻型神经功能缺损发生率低于正常尿酸组,两组比较差异均有统计学意义(P<0.05);治疗前高尿酸血症组患者伴发疾病(肥胖、高血压、糖耐量异常、高脂血症)的发生率高于正常尿酸组,高尿酸血症组治疗后的总有效率低于正常尿酸组,两组比较差异均有统计学意义(P<0.05)。结论:高尿酸血症与急性脑梗死患者的病情进展呈相关性,是预后不良的重要预测因素。%Objective:To discuss the relevance of occurrence and development with high uric acid hematic disease and acute cerebral infarction.Method: 120 patients with acute cerebral infarction in our hospital were selected from September 2013 to September 2014, according to the fasting serum uric acid level, they were divided into high uric acid hematic disease group (acute cerebral infarction patients with high uric acid hematic disease, 40 cases) and normal uric acid group (acute cerebral infarction patients with normal serum uric acid level,80 cases), according to a 1995 cerebral apoplexy clinical nerve function defect degree grading standard,the nerve function defect ratio of moderate and severe degree and light degree before treatment, concomitant disease incidence and clinical curative effect after treatment of two groups were

  19. Relationship between autophagy of melanocytes in patients with vitiligo and clinical types%白癜风患者皮肤黑素细胞自噬与临床类型的相关性

    Institute of Scientific and Technical Information of China (English)

    聂慧琼; 王平; 张小燕; 丁承; 刘娇; 许爱娥

    2016-01-01

    Objective To evaluate autophagy of melanocytes and its mechanism in patients with vitiligo and to analyze its correlation with clinical types of vitiligo.Methods Nine cases of segmental vitiligo (SV) and 11 cases of generalized vitiligo (GV) were recruited in Hangzhou Third Hospital between May 2014 and June 2015.Six people with healthy skin were recruited as controls.Epidermal melanocytes were obtained from the normal colour skin around the white spot area in SV and GV patients and from foreskin in controls for culture in vitro.Cultures for each group contained negative control and rapamycin (30 nmol/L) sub-groups.The autophagy was observed using transmission electron microscopy (TEM) and immunofluorescence laser scanning confocal microscope (LSCFM).Protein expressions of microtubeassociated protein light chain 3 (LC3 Ⅱ) and microphthalmia-associated transcription factor (MITF),tyrosinase (TYR),tyrosinase related protein (TYRP) 1,and TYRP2 were detected by Western blot.Results (1) Autophagy of melanocytes was observed under TEM and LSCFM in both SV and control groups before rapamycin treatment,but not in GV patients.The expressions of autophagosome and LC3 Ⅱ protein were increased in melanocytes in SV,GV and control groups after autophagy induction (SV group 0.58 ± 0.10 vs 0.37 ±0.06;GV group 0.57 ±0.16 vs 0.22 ±0.08;control group 0.67 ±0.09 vs 0.46 ±0.12),and the autophagy intensity was higher in the GV group compared to the SV group and the control group.(2) Before autophagy induction,the expressions of MITF,TYR,TYRP1,and TYRP2 protein were lower in the GV and SV patients compared with the control group;after autophagy induction,the expressions of MITF,TYR,and TYRP1 statistically significantly increased in melanocytes in all the three groups (all P < 0.05),while TYRP2 protein expression was not significantly changed (all P > 0.05).Conclusions Autophagy of melanocytes may be present in vitiligo and affect the expression of functional molecules

  20. Fading Customer Relationships

    OpenAIRE

    Åkerlund, Helena

    2004-01-01

    This dissertation is based on the assumption that fading customer relationships are important phenomena to understand in order for companies to prevent a future relationship termination, manage a desired relationship termination, or manage the situation where the relationship strength temporarily or permanently has weakened but where the customer still stays with the same service provider. It is assumed that fading could take different forms and develop through a range of different proces...

  1. 耳鸣临床特征与主观心理严重程度的关系%The relationship between clinical characteristics of tinnitus and subjective psychology

    Institute of Scientific and Technical Information of China (English)

    王涂路; 李颖雯; 李松键; 冯娟

    2012-01-01

    目的 了解耳鸣匹配频率及听力下降的关系及THI和VAS对耳鸣患者评价的相关性.方法 对70例以主观性耳鸣为第一主诉的耳鸣患者了解病史,进行耳科常规检查及纯音听阈、耳鸣匹配检查,并由患者填写耳鸣残疾评估量表(tinnitus handicap inventory,THI)及视觉模拟量表(visual-analogue scale VAS),综合分析各项结果.结果 在70例耳鸣患者中高音调(4 000~8 000Hz)42例,中音调(1 000~3 000Hz)16例,低音调(125~750 Hz) 12例;其与患者听力下降的最高频率(rs=0.455,P=0.000)差异有统计学意义.而不同频率及响度大小与VAS和THI评分量表差异无统计学意义.结论 不同耳鸣的频率与听力下降最高频率具有相关性,VAS和THI评分量表两者具有相关性,二者与耳鸣的主频及响度相关性不大.%OBJECTIVE To know the relationship between tinnitus matching frequency and hearing loss, and the correlativity between THI and VAS to evaluate the tinnitus patients. METHODS 70 patients with the subjective tinnitus as the first chief complain were selected, and we performed the otology routine examination, pure-tone hearing threshold test, tinnitus matching test. The tinnitus handicap inventory and visual梐nalogue scales were completed by the patients, and finally we made a comprehensive analysis on the results. RESULTS There were 42 high-pitched (4 000-8 000 Hz) patients, 16 medium loudness (1 000-3 000 Hz) patients, 12 low in tune (125-7S0 Hz) patients among the 70 tinnitus patients; It had the statistical significance with the highest frequency (r, =0.455, P = 0.000) of the hearing loss patients, but different frequencies and loudness sizes havd no statistic significance of the THI and VAS rating scales. CONCLUSION Different tinnitus frequencies have the correlativity with the highest frequency of hearing loss; THI and VAS rating scales have correlativity, while the two rating scales have little relevance with tinnitus dominant frequencies

  2. Clinical observation on the relationship between human papiliomavirus infection and Ureaplasma urealyticum infection%人乳头瘤病毒与解脲支原体感染关系的临床观察

    Institute of Scientific and Technical Information of China (English)

    公立平; 王义; 杨东梅

    2011-01-01

    Objective To explore the relationship between human papillomavirus (HPV) infection and Ureaplasma urealyticum (UU) infection. Methods There 177 cervical sampales were collected and detected for HPV and UU infectionss in gynecology and obstetrics outpatients. UU infection was screened with PCR,HPV DNA and genotyping were conducted with PCR. The patients negative for UU were as control group,and those positive for UU positive were as the observation group. Results The infection rate of UU and HPV were 29.3%(52/177),31.6%(56/177),respectedly. 21 different kind subtype of HPV was recorded. There were 31 high-risk and probably high-risk HPV cases (55.4%)(including HPV 16 in 8 cases,HPV 58 in 5 cases,HPV 31 in 4 cases,HPV 53 in 4 cases,HPV 33 in 3 cases,HPV 52 in 2 cases,HPV 66 in 2 cases,HPV 3in 2 cases,HPV 51 in 1 cases,HPV 56 in 1 cases,HPV 68 in 1 cases). The were 16 low-risk HPV cases (28.6%)(including HPV 6 in 4 cases,HPV 42 in 4 cases,HPV 54 in 3 cases,HPV 70 in 3 cases,HPV 61 inl cases, HPV 81 in 1 cases). There were also 7 unknown-risk HPV cases(13.4%)(including HPV 87 in 3 cases,HPV 84 in 2 cases, HPV 74 in 1 cases,HPV 30 in 1 cases. The HPV positive rates in the observation group and control group were 42.3%(22/ 52) and 27.2%(34/125) showing significant difference (P<0.05). Conclusion HPV infection is associated with UU infection. UU infection may increase the chance of HPV infection.%目的 探讨人乳头瘤病毒(HPV)感染与解脲支原体(UU)感染的关系.方法 对177例妇产科门诊就诊患者,采用PCR技术检测筛查UU,检查HPVDNA及其基因分型,观察其感染率,又设UU检出阳性者为观察组,设UU检出阴性者为对照组,两组进行HPV阳性率的对比分析.结果 UU的感染率为29.3%(52/177);HPV的感染率为31.6%(56/177),共检出21个不同的亚型,HPV高危型和可能高危型31例,占55.4%(31/56);HPV低危型16例,占28.6%(16/56);未知危险型7例,占13.4%(7/56);观察组HPV阳性率为42

  3. 子宫颈腺癌中HPV感染与发病年龄的临床分析%Clinical analysis of HPV infection in cervical adenocarcinoma and its relationship with age of onset

    Institute of Scientific and Technical Information of China (English)

    吴斌; 于晓红

    2015-01-01

    Purpose To discuss the relationship between age of onset and the HPV types infection in cervical adenocarcinoma. Meth-ods This study included 120 specimens of cervical adenocarcinoma in Jiangxi Maternal and Child Health Hospital. The specimen blocks were sliced by sandwich method. DNA was amplified by SPF10-PCR method. DNA genotyping was used with LiPA method. All biopsy specimens had pathologic diagnosis. The HPV infection of cervical adenocarcinoma specimens was analyzed. Results 120 ade-nocarcinoma cases were included in this study. HPV positive rate was 77. 5% (93/120). HPV 18 was the most prevalent type, which took up 43. 01% (40/93) of the total HPV positive cases, as same as HPV 16, which took up 43. 01%(40/93) of the total HPV pos-itive cases. The average ages of HPV 16 and HPV 18 were 43. 41 and 41. 06 years old respectively, other HPV types were 46. 85 years old, which showed statistically difference (F=3. 58, P=0. 032). Conclusion HPV 18 and HPV 16 are two most prevalent HPV types in cervical adenocarcinoma. The cases of HPV 18 infection are younger than other HPV-types infection.%目的:探讨子宫颈腺癌中人乳头状瘤病毒( human papillomavirus, HPV)型别感染及其与发病年龄的关系。方法收集江西省妇幼保健院存档的子宫颈腺癌标本120例,采用三明治技术进行蜡块切片,应用SPF10-PCR技术进行DNA扩增,使用反向杂交线型探针检测技术( LiPA)的方法进行HPV分型,对所有切片进行病理阅片和诊断,分析子宫颈腺癌标本的HPV感染情况。结果120例子宫颈腺癌标本中,HPV阳性率为77.5%(93/120)。子宫颈腺癌中HPV 16、18均为其主要型别,HPV 16、18在子宫颈腺癌HPV阳性患者中均占43.01%(40/93)。感染HPV 16、18患者的平均年龄分别为43.41、41.06岁,感染HPV其他型别的患者平均年龄为46.85岁,差异有统计学意义(F=3.58,P=0.032)。结论 HPV 16、18为子宫颈腺癌的主要型别,腺癌中HPV 18感染的患者

  4. Clinical study on the relationship between myofascial pain syndromes and blood uric acid level%肌筋膜疼痛综合征与血尿酸水平的关系研究

    Institute of Scientific and Technical Information of China (English)

    李益军; 林杜峰; 李庐娟; 谢美玲; 郑彬; 方细霞

    2015-01-01

    Objective:To explore the relationship between myofascial pain syndromes(MPS)and blood uric acid(BUA)level.Meth-ods:Two hundred and nineteen patients with MPS were selected and divided into group A(aged 18 -29 years),group B(aged 30 -39 years),group C(aged 40 -49 years)and group D(≥50 years old).The BUA level,visual analogue score(VAS)and tenderness score of main pain sites were measured.Meanwhile the relationship between BUA level and age,pain degree and tenderness degree of main pain sites were analyzed.Results:The patients in group A(40 cases),B(84 cases)and C(57 cases)were males,while the patients in group D (38 cases)included 25 males and 13 females.There was no statistical difference in tenderness scores and VAS of main pain sites and BUA level between the 4 groups in males(1.30 +/-0.46,1.42 +/-0.54,1.39 +/-0.56,1.76 +/-0.66 points,χ2 =9.712,P =0.121;4.52 +/-1.41,4.48 +/-1.81,4.23 +/-1.71,5.20 +/-1.71 points,χ2 =5.940,P =0.115;500.35 +/-138.85.447.81 +/-130.97. 467.86 +/-123.70,455.32 +/-101.99 μmol/L,χ2 =4.152,P =0.246).A total of 138 hyperuricemia(HUA)out of 219 MPS were diag-nosed,including 126 males and 12 females,and 30 aged 18 -29 years,50 aged 30 -39 years,37 aged 40 -49 years and 21 ≥50 years old (9 males and 12 females).Males had high-to-low incidence rate of HUA in group A,C,B and D.The result of Pearson correlation analysis showed that BUA level were positively correlated with ages,tenderness scores and VAS of main pain sites in patients with MPS(r =0.425, P =0.016;r =0.496,P =0.004;r =0.402,P =0.028).Conclusion:The incidence rate of HUA is high in patients with MPS,and the BUA level is positively correlated with ages and the degree of pain and tenderness.%目的:探讨肌筋膜疼痛综合征(myofascial pain syndromes,MPS)与血尿酸水平的关系。方法:选取219例 MPS 患者,按照年龄分为18~29岁组、30~39岁组、40~49岁组和≥50岁组。测定患者的血尿酸水平、主要疼痛部位

  5. 78 FR 20664 - Society of Clinical Research Associates-Food and Drug Administration: Food and Drug...

    Science.gov (United States)

    2013-04-05

    ... Administration: Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good... relationships among FDA and clinical trial staff, investigators, and institutional review boards (IRBs... and Working Together; (7) FDA Conduct of Clinical Investigator Inspections; (8) Meetings With FDA:...

  6. Relationship between the Clinical Effect and TCM Syndrome for Treatment of Lumbar Disc Hernination with Dragon Seven%盘龙七片治疗腰椎间盘突出症临床疗效与中医证候关系的临床观察

    Institute of Scientific and Technical Information of China (English)

    陈镜锋; 余庆阳; 李杰; 吕超锋

    2012-01-01

    Objective:To observe the relationship between the clinical effect and TCM syndrome for treatment of lumbar disc hernination with dragon seven. Methods: All 120 cases with lumbar disc hernination were randomly divided into blood stasis group, cold card group, damp heat group, and liver and kidney deficiency group according to TCM syndromes, with 30 cases in each group. They were all oral treated with dragon seven, and then, the relationship between the clinical effect and TCM syndrome was analyzed. Results:The clinical efficacy was significantly different before and after treatment with dragon seven in the blood stasis group and cold card group, but which was no different in the damp heat group and liver and kidney deficiency group. Conclusion: The dragon seven are effective for treatment of lumbar disc hernination with TCM syndromes of blood stasis and cold card. Clinicians applied of proprietary Chinese medicines should according to TCM syndromes.%目的:观察盘龙七片治疗腰椎间盘突出症临床疗效与中医证候关系.方法:通过盘龙七片治疗腰椎间盘突出症120例,按中医证候分型分为血瘀证、寒湿证、湿热证、肝肾亏虚证四种证型各30例,均采用盘龙七片口服治疗,治疗后根据其疗效评定分析盘龙七片治疗腰椎间盘突出症临床疗效与其中医证型的关系.结果:盘龙七片治疗腰椎间盘突出证属血瘀证与寒湿证两种中医证型临床疗效治疗前后有明显的差异性,而湿热瘀阻、肝肾亏虚治疗前后临床疗效比较没有明显的差异性.结论:盘龙七片治疗血瘀证、寒湿证腰椎间盘突出症具有明显有临床疗效,临床医生在临床上应用中成药时要根据中医辨证论活选择使用中成药.

  7. A clinical study on relationship of dental caries and removable partial denture of the aged patients%老年患者基牙龋病与可摘局部义齿关系的临床研究

    Institute of Scientific and Technical Information of China (English)

    李行懿; 陈娜; 刘聪

    2011-01-01

    Objective To characterize (patterns of caries after placing RPD. Methods A total of 95 patients were included in this study. A clinical examination of caries lesions on abutment teeth was conducted by me. Results The incidence of caries on abutment teeth and on nonabutment teeth were respectively 23. 67% and 3. 45%. ( P < 0.05). 27.49% of abutment teeth had new caries on the posterior oral cavity, onlyl3.89% of that on the anterior oral cavity. (P<0. 05). The incidence of caries on proximal surfaces adjacent to dentures was 25. 72% , under denture rests was 9. 33% , on root surfaces was 3. 02% , on tooth surfaces in contact with denture clasps was 1. 36% . The incidence of caries on abutment teeth of three groups classified by the oral hygienic habit were respectively 8. 91% 、24. 09%、44. 29% (P<0.01). Conclusion RPD wearers had more caries incidence. Abutment teeth had a higher of incidence of caries than nonabutment teeth. On the posterior oral cavity, abutment teeth had more caries incidence. Proximal surfaces adjacent to dentures abutment teeth had more caries incidence. Proximal surfaces adjacent to dentures were at highest risk of being decayed, surfaces under denture rests were next. The incidence of root caries on abutment teeth significantly increased. The incidence of caries on tooth surfaces in contact with denture clasps was not high.%目的 观察老年患者戴用可摘局部义齿2-3年后的龋病发病情况及其临床特点.方法 对95例戴用可摘局部义齿2-3年患者的基牙和非基牙的龋齿发病情况进行检查.结果 基牙龋齿发病率23.67%高于非基牙3.45%(P<0.05).口腔后部基牙龋齿发病率27.49%高于口腔前部基牙13.89%(P<0.05).基牙邻接面龋发病率25.72%,支托窝龋发病率9.33%,根面龋发病率3.02%,卡环龋发病率1.36%.口腔卫生习惯优、良、差三级的基牙龋齿发病率分别为8.91%、24.09%、44.29%,差异有显著性(P<0.01).结论 患者戴用可摘局部义齿后易患龋

  8. 脉压与冠状动脉病变严重程度关系的临床观察%Clinical observation of the relationship between pulse pressure and coronary artery lesions

    Institute of Scientific and Technical Information of China (English)

    詹莉; 林德鸿

    2012-01-01

    Objective To observe the correlation between pulse pressure and severity of coronary artery lesions. Methods The 24h non-invasive ambulatory blood pressure of 231 patients with coronary heart disease diagnosed by CAG, including 165 male patients and 66 female ones at the age of 33-72 years(average 51.13±11.62) were measured and divided into, based on ambulatory blood pressure, Group Ⅰ, Ⅱ and Ⅲ with pulse pressure < 40mmHg(59patients), 40-60 mmHg (107 patients) and >60 mmHg(65 patients),respectively. Severity of coronary artery lesions was assessed by coronary artery disease count. Results The incidence rates of the of coronary artery lesions of two branches in patients complicated with hypertension were 43.2% and 9.1%. and the three branches of coronary artery Lesions were 27.6% and 11.2%, obviously higher than those without having hypertention, The incidence rates of patients with 3 branches of coronary artery lesions in the pulse pressure < 40mmHg group and 40-60 mmHg group and > 60 mmHg group were 8.7%、23.5%、42.7% and in the patients can be, according to different pulse pressure. Conclusion The pulse pressure reflecting large artery elasticity is closely associated with the severity of coronary artery lLesions. It is also a risk signal indicating cardiac vascular disease for guiding early clinical intervention.%目的 观察脉压与冠状动脉病变严重程度的相关性.方法 231例经冠状动脉造影确诊的冠心病患者,男165例,女66例,年龄33~ 72岁,平均(51.13±11.62)岁.行24h无创动态血压监测,按动态脉压分为三组:脉压<40mmHg组(59例)、40~60 mmHg组(107)、>60 mmHg组(65).冠状动脉病变严重程度用冠状动脉病变支数来评价.结果 合并高血压的患者冠状动脉双支(43.2%比9.1%)及三支(27.6%比11.2%)血管病变的患病率显著高于非高血压组;三组不同脉压的患者相比,脉压< 40mmHg组、40~60 mmHg组、>60 mmHg组的患者冠

  9. 血清鸢尾素水平与糖尿病肾病及其临床代谢参数的关系%Relationship among irisin, diabetic nephropathy and it′s clinical metabolic parameters

    Institute of Scientific and Technical Information of China (English)

    杨梅丽; 陈培红; 金华; 谢心苗; 高婷; 杨莉丽; 于雪梅

    2015-01-01

    目的:探讨血清鸢尾素水平与糖尿病肾病(DN)及其临床代谢参数的关系。方法54例2型糖尿病患者中,合并DN 8例( DN组),肾小球滤过率( GFR)正常者46例(对照组)。检测两组身高、体质量、BMI、血压、骨骼肌量、体脂肪量、体脂百分比、血糖、血脂、肝肾功能指标及血清鸢尾素水平;采用Pearson相关分析法及多元线性回归分析法分析鸢尾素水平与代谢参数的相关性。结果 DN组肌酐水平高于对照组,鸢尾素水平低于对照组( P均<0.05)。鸢尾素水平与HbA1C(r=0.269,P<0.05)、GFR(r=0.327,P<0.05)、收缩压(β=0.485,P<0.05)、TC (β=1.737,P<0.05)呈正相关关系,与LDL-C呈负相关关系(β=-1.370,P<0.05)。结论 DN患者血清鸢尾素水平降低,其可能参与了DN糖脂代谢紊乱、肾功能损伤的发生。%Objective To investigated the association among serum irisin level , diabetic nephropathy ( DN) and it′s clinical metabolic parameters .Methods A total of 54 subjects with diagnosed type 2 diabetes were involved in this study , including 8 DN patients (DN group) and 46 normal glomerular filtration rate (GFR) patients (control group).Height , weight, body mass index (BMI), blood pressure, skeletal muscle, body fat mass, body fat percentage, blood glucose , se-rum lipid, hepatic function , kidney function and irisin level were measured .The association between serum irisin and met-abolic parameters was analyzed by Pearson bivariate correlation and multiple linear regression analysis .Results Compared with control group, the serum creatinine level of DN group increased and the irisin level decreased (P<0.05).Irisin level was positively correlated with HbA1C(r=0.269,P<0.05), GFR(r=0.327, P<0.05), systolic pressure(β=0.485, P<0.05), total cholesterol(β=1.737, P<0.05).Irisin level was negatively correlated with LDL-C(β=-1.370, P<0

  10. Clinical Implications of Incomplete Pancreas Divisum

    OpenAIRE

    Terumi Kamisawa; Yuyang Tu; Naoto Egawa; Kouji Tsuruta; Aatsutake Okamoto

    2006-01-01

    Context Incomplete pancreas divisum is a pancreatic anomaly that results in an inadequate communication between the ventral and dorsal pancreatic ducts. Although the relationship between complete pancreas divisum and pancreatitis has been contentious, clinical implications of incomplete pancreas divisum have not been noted. Objective This study was done to investigate the clinical significance of incomplete pancreas divisum. Patients and...

  11. Using Clinical Cases to Teach General Chemistry

    Science.gov (United States)

    Dewprashad, Brahmadeo; Kosky, Charles; Vaz, Geraldine S.; Martin, Charlotte L.

    2004-01-01

    A clinical study was designed and used to show the relationship of health and medicine, in a typical clinical scenario, where many chemical principles are involved and that an integrated knowledge of chemistry and biology is essential to the understanding, diagnosing and treating of illnesses. A case study would be a positive learning experience…

  12. Clinical cases

    International Nuclear Information System (INIS)

    This presentation is about clinical cases and the contribution of the PET - CT Fag application in the diagnosis and treatment of different types of cancer. The cases presented were: neck diseases, epidermoid carcinoma, liver damage and metastasize, lymphoma, thrombosis, colonic cancer and lung disease

  13. [Clinical pathology].

    Science.gov (United States)

    Dimitrijević, Jovan

    2006-05-01

    This work describes the basic elements of pathology used in clinical practice. Pathology plays an important role in clinical and scientific work, but only a few areas of pathology will be covered. Although the contribution of oncological and surgical pathology to therapy is the most well known, the cases chosen here will involve infectious pathology, diseases of the kidney and the liver, autoimmune diseases, as well as organ transplantation. Especially important is the description of methods that enable more accurate morphological diagnoses, such as histochemistry, immunohistochemistry, immunofluorescence, and electronic microscopy. Previous experience and joint work with clinical doctors have enabled the definition of significant morphological elements as well as of essential methods of pathohistological diagnosis. Besides, as is often the case, although disease symptoms are difficult to discern and biochemical results do not show significant changes compared to normal values, the results of biopsy come as a surprise to clinical doctors. For example, in virus hepatitis B involving so-called asymptomatic HBsAg carriers, we discovered every morphological form of hepatitis, from minimal lesions to chronic, persistent, and active hepatitis. With hepatitis C, certain morphological lesions point to the etiopathogenesis of this disease and thus help to confirm the diagnosis and to instigate therapy on time. Another significant experience involves kidney biopsies in cases when clinical findings are asymptomatic. Often, in such cases, morphological findings point to glomerulonephritis and glomerulopathy at different stages. Timely and subtle morphological diagnostics offer a more precise explanation for the pathological injury of tissues than other diagnostic methods. In this way, by adopting new methods, the work of pathologists is included more and more in everyday clinical practice. The inclusion of pathologists in a transplantation team makes sure a proper selection of

  14. Maintaining Relationship Based Procurement

    Directory of Open Access Journals (Sweden)

    Peter Davis

    2012-11-01

    Full Text Available Alliance and relationship projects are increasingin number and represent a large pool of work. Tobe successful relationship style contracts dependon soft-dollar factors, particularly the participants'ability to work together within an agreedframework, generally they are not based on lowbid tendering. Participants should be prepared todo business in an open environment based ontrust and mutually agreed governance. Theresearch evaluates relationship maintenance inthe implementation phase of constructionalliances - a particular derivative of relationshipstyle contracts. To determine the factors thatcontribute to relationship maintenance forty-nineexperienced Australian alliance projectmanagers were interviewed. The main findingswere; the development of relationships early inthe project form building blocks of success fromwhich relationships are maintained and projectvalue added; quality facilitation plays animportant part in relationship maintenance and ahybrid organisation created as a result of alliancedevelopment overcomes destructiveorganisational boundaries. Relationshipmaintenance is integral to alliance project controland failure to formalise it and pay attention toprocess and past outcomes will undermine analliance project's potential for success.

  15. Ideals in intimate relationships.

    Science.gov (United States)

    Fletcher, G J; Simpson, J A; Thomas, G; Giles, L

    1999-01-01

    This research examined lay relationship and partner ideals in romantic relationships from both a social-cognitive and an evolutionary perspective. Studies 1 and 2 revealed that the qualities of an ideal partner were represented by 3 factors (partner warmth-trustworthiness, vitality-attractiveness, and status-resources), whereas the qualities of an ideal relationship were represented by 2 factors (relationship intimacy-loyalty and passion). A confirmatory factor analysis in Study 3 replicated these factor structures but found considerable overlap across the partner and relationship dimensions. Studies 4 and 5 produced convergent and discriminant validity evidence for all 5 factors. Study 6 indicated that the higher the consistency between the ideals and related assessments of the current partner and relationship, the more positively the current relationship was evaluated. PMID:9972554

  16. The relationship between complement 3 and IgAN in clinic and pathology%C3与IgA肾病临床及病理的关系

    Institute of Scientific and Technical Information of China (English)

    吴萍; 邹军; 陈舜杰; 周波; 蒋更如

    2015-01-01

    Objectives By Oxford pathological classification and analysis of circulating complement complement 3 (C3),renal C3 deposition,and clinical laboratory tests,we discussed the correlation between complement C3 and immunoglobin A nephropathy (IgAN) in pathogenesis.Methods A retrospective study of 558 IgAN cases at Xinhua Hospital from January of 2000 through December of 2013 was performed.All 558 IgAN diagnoses were made and confirmed by renal needle biopsy.Results Compared to patients who had circulating C3 < 0.9,patients with circulating C3 level > 0.9 showed statistically significant decreases in serum creatinine [(100.92 ± 105.31) μmol/L vs (157.58 ± 208.39) μmol/L,t =-2.283,P =0.025],blood urea nitrogen [(5.69 ± 2.88) mmol/L vs (7.69 ± 5.90) mmoL/L,t =-2.81,P =0.006];besides,other parameters like IgA,body weight,body mass index (BMI),cholesterol,triglyceride,serum IgA/C3 ratio,albumin,and estimated glomeruli filtrate rate (eGFR) also presented statistically significant differences between two patient groups;no statistically significant differences were observed between two groups in glomerular mesangial cell proliferation,capillary endothelial proliferation,segmental glomerular sclerosis or adhesions,renal tubule atrophy,tubulointerstitial fibrosis,and formation of glomerular crescent;meanwhile,no statistically significant differences were observed between two groups in mesangial depositions of IgA,IgG,IgM,and complement C3;meanwhile the blood level of C3 between C3 deposition negative group,deposition 2 + and 3 + subgroup showed statistically significant differences (2.493 and 2.782;0.013 and 0.006),nevertheless,prognostic indices in Oxford classification,such as mesangial cell proliferation,capillary endothelial proliferation,segmental glomerular sclerosis or adhesions,renal tubule atrophy and tubulointerstitial fibrosis,were also statistically different between two patient groups (Pearson Square test result was 50.782,35.141,21.105,30.182,respectively

  17. 广东潮州地区强直性脊柱炎患者 HLA-B27的检测与临床相关性研究%Investigation of the relationship between clinical manifestation of ankylosing spondylitis and HLA-B27 antigen in Chaozhou, Guangdong Province

    Institute of Scientific and Technical Information of China (English)

    刘潮坚; 蔡拉加; 石昭宏; 林剑雄

    2013-01-01

      目的检测强直性脊柱炎(Ankylosing spondylitis,AS)患者 HLA-B27抗原表达情况,并分析其与临床情况的关系.方法选择我院2008年5月到2011年5月期间150例 AS 患者,按 HLA-B27抗原表达分为两组:HLA-B27阳性组(n=108)及 HLA-B27阴性组(n=42).分别检测两组血标本血沉、C 反应蛋白、α1-酸性糖蛋白水平,并检查心电图、骨盆正位片和腰椎正侧位,比较两组的发病年龄、性别比、临床症状.结果① HLA-B27阴性组以31~45岁年龄段为主(占阴性组52.4%),阳性组以16~30岁年龄段为主(占阳性组57.4%);② HLA-B27阳性组较阴性组全身症状更为严重(P0.05);③ HLA-B27阴性组较多表现为在窦缓和/或传导阻滞,而 HLA-B27阳性组则较多表现为左室高电压(P0.05).结论 AS 患者临床症状与 HLA-B27抗原有很高的相关性,HLA-B27抗原阴性患者与阳性患者相比病情较轻,预后较好.%Objective To investigate the relationships between clinical manifestation of ankylosing spondylitis (AS) and HLA-B27 antigen by analyzing the expression level of HLA-B27 antigen. Methods During May 2008 and May 2011, 150 AS patients attended our study. According to the expression level of HLA-B27 antigen, these patients were classified into two groups: HLA-B27 negative group and HLA-B27 positive group. The erythrocyte sedimentation rate (ESR), CRP, and α1-AGP, electrocardiogram, anterioposterior radiograph of pelvis, anterior and lateral lumbar vertebral X ray were also examined. The age of onset, sex proportion, and clinical manifestation were compared in the two groups. Results ① HLA-B27 negative expression mainly ranged from 31 to 45 years old (52.4%), but positive expression group mainly ranged from 16 to 30 years old (57.4%). ② The rate of systemic symptom such as fever, night sweat, and fatigue were higher in HLA-B27 positive group than that in negative group(P0.05). ③ The major clinical symptom in HLA-B27 negative patients were sinus

  18. Evaluating the effect of early clinical exposure in improving medical students' cognitive aspects of the doctor-patient relationship%早期临床接触活动对改善医学生医患关系认知的效果评价

    Institute of Scientific and Technical Information of China (English)

    赵华翔; 吕强; 张瑞; 梁蓓蕾; 范娅琦; 杜文治; 王俐媛; 孔祥秦

    2014-01-01

    目的:探究早期临床接触活动在改善医学生对当前医患关系认知方面的效果。方法采用简单随机抽样,从西安交通大学医学院已参与早期临床接触活动的2010级(n=280)和未参与该活动的2011级(n=280)本科生中,各抽取140名进行问卷调查;调查数据用Microsoft Excel录入计算机,并用SPSS对2个年级的数据行卡方检验/Fisher精确检验。应用焦点小组访谈法、深度访谈法对学生、带教教师、辅导员、从事医患关系研究的专家进行访谈,用主题分析法对收集资料进行整理分析。问卷调查和访谈涉及的主要内容为:活动细节、活动参与度/兴趣、对医患关系总体认知、专业热爱度、择业观、活动对医学生医患关系认知方面的作用及对于活动的建议和意见。结果2010级收回有效问卷134份,2011级124份。2010级学生早期临床接触活动参与率为94.0%(126/134),2011级对该活动感兴趣的学生占76.6%(95/124)。2010级学生在医患关系认知方面优于2011级(P=0.0192);早期临床接触活动对2个年级学生专业热爱度影响差异无统计学意义(P=0.7372),对其择业观影响差异有统计学意义(P=0.0002)。访谈主题词聚类为“活动前准备不够充分”“时间安排不够合理”“带教教师”“激发职业自豪感”。结论早期临床接触活动可以有效改善医学生对当前医患关系的认知,但活动实施方法和相应政策方面尚存在不足,需要后期探究和改善。%Objective This paper explored the effect of the early clinical exposure in im-proving medical students' cognitive aspects of the doctor-patient relationship. Methods (1)From 280 undergraduate students of Grade 2010 who participated in early clinical exposure of Xi'an Jiaotong University College of Medicine and 280 undergraduate students of Grade 2011 who did not participate in the early clinical exposure

  19. Exploratory analyses of the association of MRI with clinical, laboratory and radiographic findings in patients with rheumatoid arthritis

    DEFF Research Database (Denmark)

    Emery, Paul; van der Heijde, Désirée; Østergaard, Mikkel;

    2011-01-01

    Evaluate relationships between MRI and clinical/laboratory/radiographic findings in rheumatoid arthritis (RA).......Evaluate relationships between MRI and clinical/laboratory/radiographic findings in rheumatoid arthritis (RA)....

  20. Clinical biochemistry

    Science.gov (United States)

    Alexander, W. C.; Leach, C. S.; Fischer, C. L.

    1975-01-01

    The objectives of the biochemical studies conducted for the Apollo program were (1) to provide routine laboratory data for assessment of preflight crew physical status and for postflight comparisons; (2) to detect clinical or pathological abnormalities which might have required remedial action preflight; (3) to discover as early as possible any infectious disease process during the postflight quarantine periods following certain missions; and (4) to obtain fundamental medical knowledge relative to man's adjustment to and return from the space flight environment. The accumulated data presented suggest that these requirements were met by the program described. All changes ascribed to the space flight environment were subtle, whereas clinically significant changes were consistent with infrequent illnesses unrelated to the space flight exposure.

  1. 农村某基层医院护士工作压力与社会支持的相关性研究%The relationship between working pressure and social support among clinical nurses of grass-roots hospitals in Shantou rural area

    Institute of Scientific and Technical Information of China (English)

    徐友芳; 万君; 马燕君

    2013-01-01

    Objectives: To investigate working pressure and social support among clinical nurses of grass-roots hospital in Shantou, to explore the relationship between the two variables, and to provide references for managers to take targeted measures. Methods: We investigated 288 clinical nurses of grass-roots hospitals in Shantou rural area by questionnaires. Results: The mean score of working pressure was 2.81± 0.43 and in a moderate to high level. The main pressure sources were low salary and other benefits and high work-load. Working pressure negatively related to social support. Objective support was the main influencing factor of working pressure. Conclusions: Managers should pay more attention to the negative impact of the high work-load among clinical nurses in grass-roots hospitals in rural area, provide substantial and emotional support to nurses, and reduce working pressure to stabilize the nursing team, to improve clinical nurses' physical and psychological health, and to enhence working efficiency and nursing quality in grass-roots hospitals.%目的:调查基层医院临床护士工作压力及社会支持情况,并探讨两者的相关性,为管理者制订针对性的干预措施提供依据.方法:采用问卷调查法,以汕头农村地区某基层医院的288名在岗临床护士作为对象进行调查.结果:临床护士的工作压力总均分为(2.81±0.43)分,呈中等偏高水平;最大的压力源是工资及其他的福利待遇低,其次是工作量太大;工作压力与社会支持水平呈负相关;客观支持是护士工作压力的影响因素.结论:管理者应重视农村地区基层医院临床护士工作压力过高带来的负面影响,在物质和情感等方面提供支持,降低其工作压力,为稳定护理队伍,提高基层医院临床护士身心健康水平、工作效率及护理质量起到积极的促进作用.

  2. Relationship between work stress, positive coping style and anxiety on clinical doctors%医生工作压力源、应对方式与焦虑的关系--对西安三家医院调查研究

    Institute of Scientific and Technical Information of China (English)

    朱红强; 周茜; 杨玉东; 闫小飞; 孙彦; 苏景宽

    2014-01-01

    目的:本研研究探讨临床医生工作压力、积极应对方式和焦虑的关系,探讨管理对策,为促进医务人员身心健康制定相应防治对策,提供依据。方法:采用随机抽样的方法抽取临床医生352名,运用工作压力源表、积极应对方式量表以及焦虑量表对临床医生进行调查,使用SPSS统计软件对调查研究结果进行归纳,统计分析。结果:临床医生工作压力、积极应对方式以及焦虑存在着密切的关系,回归分析表明积极应对方式在临床医生工作压力和焦虑的关系中存在着完全中介作用。结论:临床医生的工作压力对焦虑的影响完全是通过积极应对方式对其焦虑产生间接作用,强调了积极应对方式在减少医生焦虑的重要性。%Objective:To explore the relationship between work stress , positive coping style and anxiety .Methods:283 Clinical doc-tors were asked to complete the work stress scale , positive coping style scale and anxiety scale .Results:Work stress was positively related to positive coping style and negatively related to anxiety on clinical doctors .Hierarchical regression analysis shown that positive coping style fully mediated the influence of work stress on anxiety on clinical doctors .Conclusion:Clinical doctors with work stress were more positively to cope with things , which decrease on their anxiety .It might be importance for decrease doctors 'anxiety to experience more positive coping style .

  3. Educational climate seems unrelated to leadership skills of clinical consultants responsible of postgraduate medical education in clinical departments

    DEFF Research Database (Denmark)

    Malling, Bente Vigh; Mortensen, Lene Sundahl; Scherpbier, Albert J J;

    2010-01-01

    The educational climate is crucial in postgraduate medical education. Although leaders are in the position to influence the educational climate, the relationship between leadership skills and educational climate is unknown. This study investigates the relationship between the educational climate...... in clinical departments and the leadership skills of clinical consultants responsible for education....

  4. Ethical Issues in Mentoring Doctoral Students in Clinical Psychology

    Science.gov (United States)

    Rosenberg, Anna; Heimberg, Richard G.

    2009-01-01

    Ethical issues abound in any relationship that is defined by differences between the parties in rank, status, and power. Such is the case in the relationship between a doctoral student in clinical psychology and his or her mentor. In this article, we examine several potential areas of ethical concern within the mentor-student relationship. We…

  5. Clinical research in allied health.

    Science.gov (United States)

    Selker, L G

    1994-01-01

    Allied health professionals in nutrition and medical dietetics, occupational therapy, physical therapy, and speech-language pathology and audiology play both unique and key cross-cutting roles in the furtherance of clinical research. Clinical research in nutrition and medical dietetics uniquely focuses on food nutrient intake and the metabolic utilization of nutrients. Clinical research in occupational therapy has a special focus on the relationship of impairment to disability, the adaptation to disability and the maximization of function. Physical therapy clinical research uniquely targets movement dysfunction and its evaluation and treatment within the context of quality and effective care. Clinical research in speech-language pathology and audiology is singular in its focus on deafness and hearing disorders, voice, speech, language and related disorders, and intersections among these and other neurological and physical conditions. Thus, all of these disciplines are making unique contributions to clinical research. Clinical research in these allied health professions is much more than the above specific foci. Inasmuch as these disciplines are rooted in practice, their contributions to research are inherently clinical. Many, if not most, of these contributions represent further validations of clinical practice or its underlying knowledge base. This means that, at a macro level, clinical research in allied health is very much "applied" research. Within allied health clinical research, this emphasis is redoubled at the "person," or individual level, where considerable attention is given to concepts of function and effectiveness. Clinical research in allied health has played a key cross-cutting role through its emphasis on collaboration. Possibly due to their professional maturation within multidisciplinary academic units, allied health professionals have demonstrated a level of comfort with multidisciplinary and interdisciplinary collaborations unique within many

  6. Gait in ageing and associated dementias; its relationship with cognition

    NARCIS (Netherlands)

    Scherder, E.; Eggermont, L.; Swaab, D.F.; Heuvelen, M. van; Kamsma, Y.; Greef, M. de; Wijck, R. van; Mulder, T.

    2006-01-01

    The focus of this review is on the close relationship between gait and cognition in ageing and associated dementias. This close relationship is supported by epidemiological studies, clinical studies of older people with and without dementia that focused on the intensity of the physical activity, cli

  7. Gait in ageing and associated dementias; its relationship with cognition

    NARCIS (Netherlands)

    Scherder, Erik; Eggermont, Laura; Swaab, Dick; van Heuvelen, Marieke; Kamsma, Yvo; de Greef, Mathieu; van Wijck, Ruud; Mulder, Theo

    2007-01-01

    The focus of this review is on the close relationship between gait and cognition in ageing and associated dementias. This close relationship is supported by epidemiological studies, clinical studies of older people with and without dementia that focused on the intensity of the physical activity, cli

  8. Mismatched: ADHD Symptomatology and the Teacher-Student Relationship

    Science.gov (United States)

    Rogers, Maria; Bélanger-Lejars, Véronique; Toste, Jessica R.; Heath, Nancy L.

    2015-01-01

    The goal of this study was to investigate the relationship between children with attention-deficit/hyperactivity disorder (ADHD) symptoms and their teachers, and to examine whether this relationship was associated with children's academic motivation. The sample comprised 35 children with clinically elevated levels of ADHD symptoms and 36 children…

  9. The Relationship of hURAT1,SLC2A9 and ABCG2 with Hyperuricemia and Gout and the Clinical Significance%hURAT1、SLC2A9、ABCG2与高尿酸血症、痛风的关系及临床意义

    Institute of Scientific and Technical Information of China (English)

    张蓓

    2013-01-01

    Hyperuricemia and gout incidence are increased steadily year by year and they have strong relationship with renal and cerebrovascular system diseases,which are drawing wide attention gradually. Recent studies have shown that genovariation of hURAT1, SLC2A9 and ABCG2 are highly correlated with hyperuricemia and gout,playing very important roles in the pathogenesis of the diseasess. Here is to make a review on the relationship between the susceptible genes and hyperuricemia and gout,and their clinical significance.%高尿酸血症和痛风与肾脏和心脑血管系统疾病的发生、发展关系密切,近年来发病率呈逐年升高趋势,逐渐引起人们的广泛重视.最近研究发现人尿酸盐转运蛋白1(hURAT1)、尿酸转运子SLC2A9和ABC转运蛋白2 (ABCG2)三个尿酸盐转运蛋白的基因变异与高尿酸血症和痛风的发生呈高度相关,在疾病发病机制中起到重要的作用.现就hURAT1、SLC2A9和ABCG2与高尿酸血症、痛风的关系及其临床意义进行综述.

  10. Relationship between neuropsychological and clinical aspects and suicide attempts in euthymic bipolar patients Relação entre aspectos clínicos e neuropsicológicos e as tentativas de suicídio em pacientes eutímicos com transtorno afetivo bipolar

    Directory of Open Access Journals (Sweden)

    Paulo Henrique Paiva de Moraes

    2013-01-01

    Full Text Available Some studies have investigated the possible relationship between suicide attempts and impulsivity in patients with bipolar disorder. The objective of this study was to assess the relationship between neuro-psychological and clinical aspects and suicide behavior in euthymic bipolar patients. The Iowa Gambling Task and the Conner's Continuous Performance Test evaluated impulsivity in 95 euthymic bipolar patients - 42 suicide attempters and 115 normal control participants. A factorial analysis evaluated the adequacy of the instruments. Furthermore, a multiple regression analysis was done in order to develop a model to predict suicide attempts. Our results point to a specific type of impulsivity related to making decisions, lack of planning and borderline personality disorder comorbidity. This type of impulsivity is a risk factor for suicide attempts in patients with bipolar disorder.Alguns estudos investigaram a possível relação entre tentativas de suicídio e impulsividade em pacientes com transtorno bipolar. O objetivo do estudo foi avaliar a relação entre características neuropsicológicas e clínicas e o comportamento suicida em pacientes bipolares eutímicos. Utilizamos o Iowa Gambling Task e o Conner's Continuous Performance Test para avaliar a impulsividade em 95 pacientes eutímicos com transtorno bipolar (42 com tentativas de suicídio e 155 controles normais. Uma análise fatorial avaliou a adequação dos instrumentos e foi criado um modelo para previsão do número de tentativas de suicídio usando regressão linear múltipla. Nossos resultados apontam para um tipo específico de impulsividade relacionada à tomada de decisões, falta de planejamento e para a comorbidade Transtorno de Personalidade Borderline. A impulsividade por não planejamento é um fator de risco para tentativas de suicídio em pacientes com Transtorno Bipolar.

  11. Customer relationship marketing

    OpenAIRE

    Sæter, Jan Øyvind

    2006-01-01

    Customer relationship marketing has become an interesting choice of strategy for companies in today’s competitive markets. Different positioning strategies like price and product quality are easy to imitate, eluding the importance of sustainable competitive advantage. The customers need to be attracted and bonded towards the store through relationships. The paper discusses several factors affecting relationship marketing and the advantages with this strategy. Through the the...

  12. Customer Energy in Relationships

    OpenAIRE

    Heinonen, Kristina; Mickelsson, Jakob; Strandvik, Tore

    2010-01-01

    All companies have a portfolio of customer relationships. From a managerial standpoint the value of these customer relationships is a key issue. The aim of the paper is to introduce a conceptual framework for customers’ energy towards a service provider. Customer energy is defined as the cognitive, affective and behavioural effort a customer puts into the purchase of an offering. It is based on two dimensions: life theme involvement and relationship commitment. Data from a survey study ...

  13. Customer Energy in Relationships

    OpenAIRE

    Heinonen, Kristina; Strandvik, Tore

    2010-01-01

    All companies have a portfolio of customer relationships. From a managerial standpoint the value of these customer relationships is a key issue. The aim of the paper is to introduce a conceptual framework for customers’ energy towards a service provider. Customer energy is defined as the cognitive, affective and behavioural effort a customer puts into the purchase of an offering. It is based on two dimensions: life theme involvement and relationship commitment. Data from a survey study of 425...

  14. 脑瘫足内、外翻的发生与脑瘫临床类型关系的探讨%A Study on the Relationship Between the Clinical Types of the Foot Inner and Outer of Cerebral Palsy and Cerebral Palsy

    Institute of Scientific and Technical Information of China (English)

    张涛

    2016-01-01

    目的:探讨脑瘫足内、外翻的发生与脑瘫临床类型的关系。方法选取2011年2月~2014年2月我科收治的脑瘫患儿510例,设计调查表,统计各临床类型脑瘫足内、外翻发生情况,找出发生规律。结果痉挛型脑瘫足内、外翻发生率分别为76.7%和68.0%,共济失调型和肌张力低下型脑瘫足外翻发生率分别为40.0%和50.0%。结论共济失调型和肌张力低下型脑瘫足外翻发生率最高,而痉挛型脑瘫足内、外翻发生率均偏高。%Objective To study the relationship between the clinical types of cerebral palsy foot inner and outer relationship and cerebral palsy.Methods From February 2011 to February 2014, 510 cases of children with cerebral palsy at our department were selected, to design the questionnaire, to count up the occurrence of the situation about the clinical types of cerebral palsy in the foot inner and outer and to ifnd out the occurrence of the law.Results The incidence rate of the inner and outer foot of spasm cerebral palsy were 76.7% and 68.0% respectively, The incidence rates of ataxia type and the outer foot of hypotonic cerebral palsy were 40.0% and 50.0% respectively. Conclusion The incidence rate of ataxia and the outer foot of hypotonic cerebral palsy was highest, the incidence rate of the inner and outer foot of spasm cerebral palsy is on the high side.

  15. Governing IT outsourcing relationships

    CERN Document Server

    Kuhlmann, Daniel

    2012-01-01

    Hauptbeschreibung The dynamics of the relationship between service recipient and service provider in IS outsourcing relationships recently gained increased attention as relationships are believed to have a considerable influence on IS outsourcing success. This study adds to this growing field of interest by developing an IS outsourcing relationship framework in the form of a process model. Three rather disjointed areas of research, namely contractual governance, relational norms, and control, have been set in a common context by interrelating them as the three main governance modes

  16. 某市临床护士健康相关生命质量及其与应激源关系的探讨%Study on relationships between health-related quality of life and its stress source for clinical nurses in Lu'an city

    Institute of Scientific and Technical Information of China (English)

    朱文娟; 胡传来; 沈国文

    2013-01-01

    Objective To investigate the relationships between health - related quality of life and its stress sources for clinical nurses. Methods All 500 clinical nurses from two hospitals in Luan city were recruited in this study. Questionnaire of sociodemographic characteristics , stressor scale of nurse work, scales of family functioning ( APGAR ) and social support, health - related quality of life ( SF - 36 ) were selected for quantitative measurement. Statistics was showed with mean ± SD. Regression and multivariate logistic regression statistical analysis was applied to explore the health risks. Results Health - related quality of life scores were lower in nurses than the national popunl-atin norm, and all of the eight dimensions had obvious correlation with the source of stress. With the regression analysis, stressors of interpersonal communication in the relationship between the pressure of the nurses'psychosocial stressors, learning and promotion pressure had a significant impact on the health - related quality of life in clinical nurses. Source of stress in daily life and work, family functioning, social support could significantly affect the health -related quality of life. Conclusion It is suggested that intervention in family functioning, working conditions, and increasing social support actions should improve the health - related quality of life for clinical nurses.%目的 调查某市临床护士健康相关生命质量及其与应激源的关系.方法 对某市500名临床护士应用一般情况调查表、护士工作压力源量表、家庭功能量表、社会支持量表及生命质量评价量表进行问卷调查,并对结果进行分析.结果 护士生命质量的各个维度得分均低于常模分值,8个维度均与应激源有明显的相关性.通过回归分析可见人际沟通应激源中护士与护士关系压力,社会心理应激源中学习与晋升压力对护士生命质量的影响具有统计学意义.日常生活和工作中的

  17. 深圳市三级医院临床护士工作满意度与离职倾向的关系研究%Relationship between job satisfaction and turnover intention of clinical nurses at tertiary hospital in Shenzhen

    Institute of Scientific and Technical Information of China (English)

    吴清香; 彭卫群; 王琦; 丁小容

    2009-01-01

    目的 探讨深圳市三级医院临床护士的工作满意度与离职倾向的关系及其影响因素.方法 采用问卷调查法,对深圳市3家非营利性三级综合性医院646名临床护士进行工作满意度和离职倾向的问卷调查.结果 内、外在满意度和总满意度与离职倾向的pearson相关系数r分别为-0.49、-0.57、-0.56(均P<0.01);不同工龄的临床护士工作满意度得分差异有统计学意义(P<0.05),不同年龄、工龄和任职方式的临床护士离职倾向得分差异有统计学意义(P<0.01).结论 临床护士的工作满意度与离职倾向呈显著负相关,即满意度越高,离职倾向越低;人口特征因素对临床护士的工作满意度和离职倾向分别有不同的影响.建议医院及护理管理者应结合护士的具体情况,采取多种激励手段相结合,从而有效地提高临床护士的工作满意度,降低离职率,稳定护理队伍.%Objective To discuss the relationship between job satisfaction and turnover intention of clinical nurses at tertiary hospitals in Shenzhen. Methods By survey method, 646 clinical nurses were investigated about their job satisfaction and turnover intention in 3 tertiary hospitals in Shenzhen. Results The Pearson correlation coefficient of job satisfaction and turnover intention were -0.49, -0.57, -0.56 (P<0.01) . The difference in the scores of job satisfaction of clinical nurses with different length of service had statistical significance (P <0. 05) . The difference in the scores of turnover intention of clinical nurses with different age, length of service and duty had statistical significance (P<0.01) . Conclusions There is negative relationship between job satisfaction and turnover intention. Population characteristics factors have different influence on job satisfaction and turnover intention. The managers should take different motivator to improve job satisfaction effectually according to the different conditions of nurses, reduce

  18. Participating in Clinical Trials

    Science.gov (United States)

    ... this page please turn Javascript on. Participating in Clinical Trials About Clinical Trials A Research Study With Human Subjects A clinical ... to treat or cure a disease. Phases of Clinical Trials Clinical trials of drugs are usually described based ...

  19. Psychiatrists and clinical psychologists

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2006-03-01

    Full Text Available Psychiatrists and clinical psychologists share an inevitable, if rather uneasy, relationship. So very much like a modern marriage. Can't do without it, can't get out of it. Both sides contemplate divorce often. Think of separation by mutual consent. Even keep threatening as they rave and rant. Have secret, and not so secret, flings on the side. But, like the proverbial homing bird, or the conservative Indian arranged marriage, have no option but to stick it out with each other. Psychiatrists are otherwise good people. But that does not make them immune to handling clinical psychologists with the condescending tolerance and patronizing acceptance that teachers, for example, have towards rambling students. Or the rich have towards the poor. This does not take long to get converted into exasperation and smirky asides in the less charitable amongst the psychiatrists. Not that clinical psychologists are very helpful in motivating the psychiatrists to change for the better. For they, like most people in their position, over react and get aggressive when confronted with this attitude. And understandably so. However, it is time both realized their attitudes were not helpful either for mutual interaction, or growth of the Mental Health Movement at large. We can understand why psychiatrists behave the way they do. They are exposed to this same condescending-patronising attitude from their own peers in the medical profession. Their medical colleagues have yet to develop a feeling of healthy respect for psychiatry. Psychiatrists, no doubt, feel this is unjustified, but their peers are still in a position to deny them the respect and acceptance they seek. What they get from their medical colleagues, they unwittingly pass on to their clinical psychologist colleagues. But understanding why it occurs does not absolve them of their responsibility to behave more rationally, rather than emotionally, with the latter. [No abstract available.

  20. Number Relationships in Preschool

    Science.gov (United States)

    Jung, Myoungwhon

    2011-01-01

    When a child understands number relationships, he or she comprehends the meaning of numbers by developing multiple, flexible ways of representing them. The importance of developing number relationships in the early years has been highlighted because it helps children build a good foundation for developing a more sophisticated understanding of…

  1. Relationship violence in adolescence.

    Science.gov (United States)

    Lin, Alison J; Raymond, Marissa; Catallozzi, Marina; Ryan, Owen; Rickert, Vaughn I

    2007-12-01

    Previous experience with violence or a deficit in interpersonal skills may lead to violence in adolescent relationships. In this article we focus on various forms of interpersonal violence (bullying, sexual harassment, coercion, and relationship violence) that adolescents may experience and pay special attention to risk factors, help-seeking behaviors, and sequelae.

  2. Relationship Building Blocks

    Science.gov (United States)

    Santabarbara, Todd; Erbe, Ryan; Cooper, Scott

    2009-01-01

    Intimate or romantic relationships for young people today play an integral role in their health and quality of life. Between the ages of 11 and 13 students become more interested in the opposite sex and as a result they begin to develop more intimate relationships. Around this age students are learning to deal with these feelings of attraction and…

  3. Jealousy and Relationship Closeness

    Directory of Open Access Journals (Sweden)

    Mark Attridge

    2013-02-01

    Full Text Available This study confirmed a hypothesis from the Emotion-in-Relationships conceptual model, which predicts that greater interdependence between relationship partners—or closeness—creates the potential for jealousy. The study also sought to better define the positive side of romantic jealousy in addition to its more negative attributes. College students in premarital relationships (N = 229 completed a questionnaire, including 27 different measures and the Multidimensional Jealousy Scale. Select data were obtained from 122 cases at 3-month follow-up. Each jealousy scale was tested for associations with demographic (age, sex, and race, person (life satisfaction, loneliness, romantic attachment styles, love styles, and romantic beliefs, and relationship (affective, closeness, and social exchange theory constructs. Results clearly distinguished emotional/reactive jealousy as mostly “good” and cognitive/suspicious jealousy as “bad.” Behavioral jealousy was associated with few measures. Implications are discussed for the interdependence model of relationships and the transactional model of jealousy.

  4. Effects of job satisfaction and life satisfaction on the relationship between emotional intelligence and work engagement of clinical nurses%工作满意度和生活满意度在临床护士情绪智力和工作投入关系中的作用

    Institute of Scientific and Technical Information of China (English)

    冯婷; 闫晓飞; 胡雪慧; 苏景宽

    2015-01-01

    目的 探讨工作满意度和生活满意度在临床护士情绪智力和工作投入关系中的作用,为管理者采取针对性的措施提升护士工作投入提供有效依据. 方法 采用情绪智力量表、工作满意度量表、生活满意度量表和工作投入量表,对西安市某三级甲等医院使用随机抽样方法选取的380 名临床护士进行调查,采用SPSS 16. 0统计软件对数据进行分析. 结果 发放问卷380份,收回问卷378份,经过初步分析,剔除无效问卷14 份,则有效问卷364 份. 364 名护士情绪智力的总分为(60. 41 ± 8. 11)分,生活满意度总分为(19. 26 ± 6. 85)分;工作满意度总分为(71. 85 ± 10. 21)分;工作投入总分为(82. 18 ± 16. 62)分. 临床护士的情绪智力、生活满意度和工作满意度与工作投入均呈正相关( r=0. 40~0. 65,P<0. 01),临床护士的情绪智力对工作投入有直接的预测作用,工作满意度、生活满意度均在临床护士情绪智力与工作投入的关系中存在部分中介作用. 结论 工作满意度、生活满意度均在临床护士情绪智力与工作投入的关系中存在部分中介作用,护理管理者应有效提升临床护士的情绪智力,帮助护士从个人角度创造更高的工作满意度和生活满意度,有益于临床护士工作投入水平的提高.%Objective To explore the effects of job satisfaction and life satisfaction on the relationship between emotional intelligence and work engagement of the clinical nurses, in order to provide effective evidence of corresponding measures for managers to enhance nurses′work engagement. Methods A total of 380 clinical nurses were selected randomly from a tertiary referral hospital in Xi′an, who were investigated by emotional intelligence scale, job satisfaction scale, life satisfaction scale, and work engagement scale. Results We distributed 380 questionnaires, collected 378, and rejected 14 invalid one after analysis, so it was total 364

  5. Close partner relationships

    Directory of Open Access Journals (Sweden)

    Stefanović-Stanojević Tatjana Z.

    2002-01-01

    Full Text Available According to the theory of emotional attachment, specific emotional relationships are being established at an early age between a child and its parents. On the basis of the quality of these relationships the child creates the so-called internal working model ie the image of itself as well as others. The working model persists throughout one's lifetime, shaping in part the quality of adult relationships. Thus, a dominant adult relationship is a close, partner or love one. Within the indicated theoretical context, we were interested in finding out whether there is a statistically significant link between the emotional ties of parents and their children formed in early childhood. The investigation included 180 grown-ups of the same sex and age. For investigating close partner relationships the test Experience in Close Relationship by the American authors (Brenan K.A., Clark C.L., & Shaver P.R. 1998. was used, while the early emotional relationships were investigated using a test which has been the only one so far to measure this quality in adults - Adult Attachment Interview, (Main M., Casidy J., & Kaplan N., 1985. The results show there is a statistically significant link between the observed variables.

  6. Study on the relationship among psychological resilience, work stress, and anxiety and depression of psychiatric clinical staff%精神科医护人员心理韧性、工作压力与焦虑抑郁情绪关系

    Institute of Scientific and Technical Information of China (English)

    文超; 蒋春雷; 谭莉娜; 李桂克; 刘博

    2014-01-01

    Objective To explore the psychological resilience of psychiatric clinical staffs and its relationship among work stress, and anxiety and depression .Methods Two hundred and twenty psychiatric clinical workers in 4 hospitals in the Guangxi Zhuang Autonomous Region were sampled and tested by Chinese Version of Connor -Davidson Resilience Scale , Clinical Staff Occupational Stressors Scale , Self Rating Anxiety Scale and Self Rating Depress Scale .According to the scores of psychological resilience , the subjects were divided into 3 groups of high resilience , medium resilience and low resilience.Results There job stress scores of high resilience group were lower than those of the medium and low resilience groups ( P <0.01 ) .And the anxiety and depression scores among different resilience groups were also significantly different (P<0.05), showing high resilience group clinical workers ’ anxiety and depression emotion [ the standardized regression coefficient (β) were -0.255, -0.325;P<0.01];work stress could positively predict the psychiatric clinical workers’ anxiety and depression emotion (βwere 0.247, 0.185;P<0.01); mediation effects of resilience among work stress and anxiety, depression emotion were significant (P<0.01).The mediating effect inspection results showed βof anxiety and depression to work stress dropped from 0.298 and 0.258 to 0.210 and 0.144 respectively after using the psychological resilience as a mediating variable .Conclusion Resilience and work stress are significant predictors of anxiety and depression emotion of psychiatric clinical staff , and the resilience partially mediates the relationship among work stress and anxiety , depression.%目的:探讨精神科医护人员心理韧性、工作压力与焦虑抑郁情绪的关系。方法采用心理韧性量表、临床医护人员工作压力源量表、焦虑自评量表

  7. On writing from clinical experience.

    Science.gov (United States)

    Scharff, J S

    2000-01-01

    Papers that present the life of the analytic session offer material through which analysts can together study analytic process and therapeutic action and arrive at consensus on how to improve psychoanalytic theory and practice. But some analysts have been deterred from publishing clinical material of that kind because of concerns about preserving confidentiality, protecting the therapeutic relationship, reporting accurately, being scrutinized, worrying about losing their colleagues' support, and not feeling authorized to present their views. Here conscious, preconscious, and unconscious constraints against writing and publishing are explored, and an example is given of successful self-analysis of a writing inhibition. The debate over the ethics of writing is reviewed and an argument made that detailed clinical description is useful in advancing analytic understanding. Finally, a clinical example shows how the analysand usefully analyzes the experience of reading what the analyst has written, and how the analyst's self-analysis may be promoted in resonance with the analysand's experience.

  8. cbIC型甲基丙二酸血症基因型与临床表型及疗效的关系%Relationship of genotypes with clinical phenotypes and outcomes in children with cobalamin C type combined methylmalonic aciduria and homocystinuria

    Institute of Scientific and Technical Information of China (English)

    宇亚芬; 黎芳; 麻宏伟

    2015-01-01

    ObjectiveTo analyze mutation types, clinical features, and treatment outcomes of cobalamin C (cblC) type combined methylmalonic aciduria and homocystinuria (MMA-HC) and to investigate the relationship of genotypes with clinical phenotypes and outcomes.MethodsThe clinical data of 16 Chinese children diagnosed with cblC type MMA-HC by gene analysis were retrospectively analyzed. According to the onset age, the patients were classified into early onset (≤1 year) and late onset (>1 year). According to the clinical phenotype, the patients were classiifed into mild, moderate, and severe groups. All the patients were treated with vitamin B12 (cyanocobalamin) or hydroxocobalamin, betaine, folate, vitamin B6, and L-carnitine.ResultsFifteen patients belonged to the early onset type, including 11 in the severe group and 4 in the moderate group. The remaining one belonged to the late onset type. Seven reported mutations and two novel mutations (c.445_446delTG and c.349G>c) were detected. The c.609G>A and c.658_660delAAG were the most common mutations detected in 13 (81%) out of 16 patients. The genotype caused by compound heterozygous mutations of these two alleles (c.609 G>A/c.658_660delAAG) was the most common in the patients, detected in 4 (25%) out of 16 patients. Patients with this genotype had severe microcephaly and eye diseases and these clinical manifestations were not improved after the treatment. The patient with late-onset cblC type MMA-HC had normal clinical phenotypes after treatment. In the 15 early onset patients, the more severe the clinical phenotype, the worse the treatment outcome.ConclusionsThe cblC type MMA-HC mainly manifests as early onset in China and c.609G >A and c.658_660delAAGare the most common mutations causing this disease. The clinical phenotypes are associated with the outcomes in children with cblC type MMA-HC.%目的:分析cbIC型甲基丙二酸血症伴同型半胱氨酸血症(合并型MMA)基因突变情况、临床特点及治疗

  9. 儿童青少年淋巴系统恶性肿瘤患者血清血管内皮生长因子水平与临床关系%Relationship between serum VEGF level and clinical feature in children and adolescent with lymphoid malignancy

    Institute of Scientific and Technical Information of China (English)

    罗文标; 孙晓非; 张昌卿; 夏奕; 甄子俊; 王智辉; 凌家瑜; 郑磊; 林慧

    2008-01-01

    Objective To investigate the relationship between serum-VEGF(sVEGF)and clinical features in children and adolescent patients with non-Hodgkin lymphoma(NHL) and acute lymphoblagtic leukemia(ALL).Methods The sVEGF in 101 of pretreated NHL and ALL patients were detected by enzymelinked inununosorbent assay(ELISA).The sVEGF prior and post-treatment were compared in 61 patients who achieved complete remission(CR).Results The median sVEGF was 567.70 ng/L in 81 prior-treated NHL patients.It was significantly higher than that in normal controls(P<0.001).The median sVEGF wag 253.90 ng/L in 49 patients with CR,which was significantly different compared to pretherapeutic level(P<0.001),whereag no statistical difference was observed compared to the normal controls. No relationships were found between sVEGF and clinical indexes such as clinical stage,"B"symptoms,gender,performance status(PS)score,bulk and serum lactate dehydrogenage (LDH)et al in untreated NHL patients.The median sVEGF was 198.60 ng/L in 20 untreated ALL patients.which wag no statistically different in comparison with that of normal controls.And the median sVEGF wag 181.73 ng/L in 12 of the CR ALL patients.which wag not statistically different in comparison with that in prior-treatment group or normal controls.Conclusion This study showed that the sVEGF in untreated children and adoleseent patients with NHL were higher than that of normal controls.The high sVEGF dmpped after achieving CR.There was no relationship between the level of sVEGF and clinical characteristics in the NHL patients.The sVEGF level in untreated ALL patients wag not difierent compared to that of the normal controls.and there was no change for sVEGF after chemotherapy in ALL patients.%目的 探讨儿童青少年非霍奇金淋巴瘤(NHL)和急性淋巴细胞性白血病(ALL)患者血清血管内皮生长因子(sVEGF)水平与临床的关系.方法 使用ELISA法检测101例3个月~20岁NHL和ALL患者初诊时sVEGF水平,并对

  10. A Solid Relationship

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    May 21 marks the 55th anniversary of the establishment of diplomatic relations between China and Pakistan. This bilateral relationship has stood the test of time and may well serve as an exemplary model in contemporary international relations.

  11. Human-Forest Relationships

    DEFF Research Database (Denmark)

    Ritter, Eva; Dauksta, Dainis

    2012-01-01

    The relationship between forests and people goes back to the early development of civilisation. However, parallel with technical innovations and an increasing urbanisation of the society, an alienation from nature has taken place......The relationship between forests and people goes back to the early development of civilisation. However, parallel with technical innovations and an increasing urbanisation of the society, an alienation from nature has taken place...

  12. Interaction, Relationships And Networks

    OpenAIRE

    Benson-Rea, M

    1999-01-01

    This paper presents four case studies which have been selected to represent different insights into the strategic evaluation of relationships within one industry. From an analysis of how each of the case study firms has formed its networks of relationships, within its overall approach to industry strategy, we discuss how the interactions are evaluated, with a particular emergent focus on social or actor bonds. The strategy literature models strategy formation processes and content. The networ...

  13. Romantic Relationships and Love

    OpenAIRE

    Hasan Atak; Nuray Tastan

    2012-01-01

    Intimacy or love is completely defined as a personal relationship or sometimes a specific component of personal relationships or even a particular emotion that someone feels for another. Love is appearing as a psychological concept in the area of psychology in recent years. The definition of love depends on culture and people. Love comes with the concepts such as intimacy, attachment, respect and mature love. In this context, love is evaluated conceptually in this paper in order to fill the l...

  14. RELATIONSHIP MARKETING - THEORETICAL CONSIDERATION

    OpenAIRE

    Iacob Catoiu; Mihai Tichindelean

    2012-01-01

    The purpose of the paper is to propose a set of research perspectives for therelationship marketing theory. A comprehensive literature review is undertaken which entails threedifferent understandings of relationship marketing. First, relationship marketing is considered as amarketing strategy within the unifying theory of the service dominant logic. Second, relationshipmarketing is presented as the new understanding or paradigm of marketing. Third, relationshipmarketing theory is correlated a...

  15. Customer Relationship Management

    OpenAIRE

    Conf. univ. dr. Enache Elena; Asist. univ. drd. Marin Carmen; Conf. univ. dr. Vechiu Camelia

    2010-01-01

    The most significant changes in the practice of marketing during the last decade in the shift in emphasis from a transaction orientation to the customer relationship management (CRM). Customer relationship management is a strategy of organization to identifying the main desire of the customer and the behaviour commercial business, the beneficial use of information acquired in order to improve relations with these factors, with the objective of increasing customer satisfaction requirements.

  16. The Relationship of Personality to Eating Disorders

    Directory of Open Access Journals (Sweden)

    Mohammad Ali Besharat

    2008-01-01

    Full Text Available This paper highlights a variety of personality disorders in individuals with eating disorder and also emphasizes the importance of identifying clinically meaningful eating disorders subtypes based on concurrent personality disorder. The relationship between personality disorders and eating disorders is an important issue as this association has implications for assessment and treatment. Different hypotheses concerning the relationship between personality disorders and eating disorders will be reviewed. The prevalence rates of concomitant personality disorder diagnoses in eating disorder patients is highlighted to illustrate some of the pertinent conceptual issues concerning the meaning of the co-occurrence of separately defined diagnostic entities. The literature review reveals a robust finding that patients with ersonality pathology have a poorer response to treatment of Axis I disorders than those without such pathology. It is also argued that therapeutic relationship deserves more attention in the assessment and treatment of eating disorder patients with a co morbid personality disorder.

  17. 慢性肾衰虚实兼证面诊特征信息与肾功能的关联研究%Studies on Relationship Between the Facial Complexion Characters And Kidney Function in TCM Clinical Syndrome of Chronic Renal Failure

    Institute of Scientific and Technical Information of China (English)

    曹燕亚; 张瑞仪; 张伟妃; 郑晓燕; 赵洁; 李福凤

    2012-01-01

    目的:探讨慢性肾衰邪实兼证面色参数与病理生化指标的相互关系.方法:应用中医面色检测仪检测慢性肾功能衰竭患者面色特征信息,同步收集其病史资料及病理生化指标.结果:慢性肾衰虚实兼证各面色参数与病理生化指标之间存在一定的相关性:虚兼湿浊证面色参数中黑色比例与尿酸的相关系数为-0.158;虚兼湿热证面色指数与尿素氮的相关系数为-0.278.结论:慢性肾衰虚实兼证的面色参数与临床病理生化指标尿素氮、血肌酐、尿酸、肾小球滤过率存在一定的相关性,表明中医临床病证面色变化可用现代医学语言来诠释.%Objective:To discuss the relationship of the facial color parameters and the pathological - biochemical indicators of the CRF with different syndromes. Methods: Applying TCM facial color detector apparatus to gathering the facial color characteristic information of CRF patients. Collecting the medical history datum and pathological - biochemical indicators at the same time. Results:There are some certain correlations on the facial color parameters and pathological - biochemical indicators among the deficiency - excess Syndromes of chronic renal failure: wet muddy syndrome, the black proportion of facial color parameters with BNA correlation coefficients was -0. 158; hot and damp syndrome, facial color index with BUN correlation coefficients was -0.278. Conclusions: Chronic renal failure five syndromes facial color parameters and clinical pathology blood urea nitrogen, serum creatinine, uric acid, glomerular filtration rate and albumin exists certain correlation, indicating that facial color changes in Chinese medicine clinical syndrome can interpret the language of modern medicine Language.

  18. 医科院校临床医学专业学生家庭功能与考试焦虑的关系研究%Studying on the relationship between family function and test anxiety among clinical medical students in medical college

    Institute of Scientific and Technical Information of China (English)

    孔令玲; 于国华; 张骞; 曲海英; 徐娜

    2014-01-01

    目的:探讨临床医学专业学生家庭功能与考试焦虑的关系。方法采用整群取样,从山东省某医学院校选取645名大学生为被试,应用家庭功能评定量表、考试焦虑量表进行调查。结果存在考试焦虑不适感的学生占61.2%;高家庭功能组和低家庭功能组在考试焦虑水平上存在显著性差异(t=-5.15,P<0.01);临床医学专业学生家庭功能与考试焦虑存在显著正相关(t=0.238,P<0.01);多元回归显示,总的功能和角色两个因子对考试焦虑有显著的预测作用(β=0.145,β=0.131;P均<0.01)。结论家庭功能是影响临床医学专业学生考试焦虑的一个重要因素。%Objective To explore the relationship between family function and test anxiety among clinical medical students .Meth-ods Totally 645 clinical graduates in some medical university of Shandong were selected with cluster sampling and investingated with Family Assessment Device and Test Anxiety .Results 38.8%of participants had test anxiety discomforts .There were significant differ-ence on test anxiety between high family function group and low family function group (t=-5.15,P<0.01).There was positive corre-lation between family function and test anxiety (t=0.238,P<0.01).Multi-regression analysis showed that:general function and explic-it character could predict test anxiety (β=0.145,β=0.131;respective,P﹤0.01).Conclusion There is close correlation between family function and test anxiety and family function has a great influence on test anxiety of the students .

  19. Relationship between the expression of Ki-67 and molecular classification and clinical patho-logical features in breast cancer%Ki-67表达与乳腺癌分子分型及临床病理特征的关系

    Institute of Scientific and Technical Information of China (English)

    张莹; 任占平; 张芫

    2014-01-01

    目的:观察不同分子亚型乳腺癌中Ki-67的表达及其与乳腺癌临床病理特征的关系及意义。方法采用免疫组化En-Vision两步法检测245例乳腺癌组织中ER、PR、HER-2及Ki-67的表达,并比较Ki-67表达与乳腺癌临床病理参数的关系。结果不同分子分型乳腺癌中Ki-67的增殖指数差异有统计学意义( P50岁组的Ki-67增殖指数差异无统计学意义;患者按≤40岁及≥60岁分为年轻组及老年组时,年轻组Ki-67增殖指数明显高于老年组。结论 Ki-67在三阴型乳腺癌、年轻患者、伴腋窝淋巴结转移、肿块较大及ER、PR阴性组中的增殖指数较高。 Ki-67可作为判断乳腺癌预后的重要指标。%Purpose To study the expression of Ki-67 in breast cancer with different molecular classification, and to discuss the rela-tionship between the expression of Ki-67 and clinical pathological features in breast cancer. Methods All 245 patients with breast cancer were divided into different molecular classification through detecting the expression of ER, PR, HER-2 by immunohistochemical method. The expression of Ki-67 was also detected, and to study relationship between the expression and clinical pathological features. Results The difference of Ki-67 index was statistically significant in different molecular classification of breast cancer. Ki-67 index in patients with lymph node metastasis and larger tumor size were higher than that with no metastasis and smaller tumor size. Ki-67 index in patients with ER and PR positive were lower than that negative, the difference was statistically significant. Ki-67 expression differ-ence was not statistically significant between the two groups according to the median age (50 years old). But when patients were divid-ed into young and elderly groups by≤40 and≥60 years old, Ki-67 index in young group was more higher than that in elderly group. Conclusion Ki-67 index in patients with triple-negative breast cancer, young

  20. Second generation plant health clinics in Uganda

    DEFF Research Database (Denmark)

    Danielsen, Solveig; Matsiko, Frank; Mutebi, Emmanuel;

    to enhance the coverage of existing extension services. Many factors influenced the performance of plant health clinics, from practical, everyday concerns of clinic staff to the policy framework that shapes public sector activities and relationships with the NGO and private sectors. While the basic aspects...... of clinic operation were well understood by all organisations, there were no common standards for record keeping, data management, monitoring and reporting, either internally in the clinic organisations or externally from the backstopping institutions. There was also no functional system to refer samples....... Ownership was strengthened and clinic management improved with stronger local leadership. It was nonetheless evident that the clinic initiative expanded in a loose and unregulated way. It was not always clear who was leading the activities and providing the overall championship to guarantee that basic...

  1. Teaching and Clinical Efficiency: Competing Demands

    OpenAIRE

    Colletti, James E; Flottemesch, Thomas J.; O'Connell, Tara; Ankel, Felix K.; Asplin, Brent R.

    2012-01-01

    Introduction: Teaching ability and efficiency of clinical operations are important aspects of physician performance. In order to promote excellence in education and clinical efficiency, it would be important to determine physician qualities that contribute to both. We sought to evaluate the relationship between teaching performance and patient throughput times. Methods: The setting is an urban, academic emergency department with an annual census of 65,000patient visits. Previous ana...

  2. Clinical applications of Genome Polymorphism Scans

    OpenAIRE

    Weber James L

    2006-01-01

    Abstract Applications of Genome Polymorphism Scans range from the relatively simple such as gender determination and confirmation of biological relationships, to the relatively complex such as determination of autozygosity and propagation of genetic information throughout pedigrees. Unlike nearly all other clinical DNA tests, the Scan is a universal test – it covers all people and all genes. In balance, I argue that the Genome Polymorphism Scan is the most powerful, affordable clinical DNA te...

  3. Clinical Psychology and Research: epistemological notes

    OpenAIRE

    Emanuela Coppola; Carmela Mento

    2013-01-01

    The paper proposes a reflection on the relationship between clinical psychology and research, highlighting the constant epistemological crossing the two practices, empirical and professional. The paper warns against the pitfalls of reductionism that, in both cases, may impact the effectiveness of therapeutic results. In fact, both in clinical practice and is in psychological research, the mere application of techniques contradicts the specificity of the object of study (the mind) which, rathe...

  4. Impact of QRS duration on the relationship between left ventricle lead electrical delay and clinical response after cardiac resynchronization therapy%QRS时限对左心室导线电延迟与心脏再同步治疗长期疗效相关性的影响

    Institute of Scientific and Technical Information of China (English)

    樊晓寒; 华伟; 陈柯萍; 孙欣; 杨新伟; 刘志敏; 郑黎辉; 张澍

    2014-01-01

    目的 探讨QRS时限是否影响左心室导线电延迟(LVLED)与心脏再同步治疗(CRT)长期疗效的相关性.方法 前瞻性入选2011年10月至2013年3月在阜外心血管病医院成功植入CRT患者,在围术期测量Q波起始到左心室导线感知波最高峰的时间间距(QLV)反映LVLED.根据患者基线QRS时限分为宽QRS组(≥150 ms)和窄QRS组(<150 ms),基线及术后定期检查超声心动图及随访情况.CRT有反应定义为术后最后1次随访时左心室射血分数提高≥0.05.结果 共入选93例患者,81例患者完成(15±3)个月的随访.平均年龄(60.1±10.4)岁,72%为左束支阻滞,80%为非缺血性心肌病,37.0%为女性.宽QRS组61例,窄QRS组20例.宽QRS组的QLV显著长于窄QRS组[(109.9±38.1) ms对(77.5±37.6) ms,P<0.05].整体CRT有反应率为66.7%.宽QRS组CRT有反应率显著高于窄QRS组(72.1%对50%,P<0.05).在宽QRS组,CRT有反应率随QLV四分位分组显著增加(57.0%,73.3%,80.0%,87.5%,P=0.017).但窄QRS组QLV四分位组间CRT有反应率差异无统计学意义(P>0.05).多因素回归分析校正年龄、性别、束支阻滞和缺血性心肌病后,宽QRS组长QLV与CRT有反应显著相关(OR4.12,95% CI 2.17~8.68,P=0.012).但窄QRS组QLV与CRT反应无相关性(P>0.05).结论 只有当基线QRS时限≥150 ms时,应用LVLED指导左心室导线位置有助于提高CRT的长期疗效.%Objective The left ventricle lead electrical delay (LVLED)has been associated with reverse remodeling after cardiac resynchronization therapy(CRT).The impact of QRS duration on the relationship between LVLED and CRT clinical response remains unclear.Methods We prospectively enrolled a series of consecutive patients undergoing CRT implantation according to standard clinical indications.The LVLED was measured from the onset of the surface electrco cardiogram QRS complex to the first large peak of the unipolar LV tip to can intracardiac electrogram during spontaneous

  5. Conflict resolution in adolescent relationships

    NARCIS (Netherlands)

    van Doorn, M.D.

    2008-01-01

    Conflict is an inevitable feature of social relationships. When people interact, disagreements may arise. Especially in close relationships, people sometimes disagree. Although conflict might jeopardize relationships, conflict is not necessarily detrimental. The way conflicts are handled is importan

  6. Educational climate seems unrelated to leadership skills of clinical consultants responsible of postgraduate medical education in clinical departments

    DEFF Research Database (Denmark)

    Malling, Bente Vigh; Mortensen, Lene S.; Scherpbier, Albert J J;

    2010-01-01

    The educational climate is crucial in postgraduate medical education. Although leaders are in the position to influence the educational climate, the relationship between leadership skills and educational climate is unknown. This study investigates the relationship between the educational climate ...... clinical departments and the leadership skills of clinical consultants responsible for education.......The educational climate is crucial in postgraduate medical education. Although leaders are in the position to influence the educational climate, the relationship between leadership skills and educational climate is unknown. This study investigates the relationship between the educational climate in...

  7. The relationship between clinical manifestations and collateral circulation and its factors in patients with internal carotid artery occlusion%颈内动脉闭塞患者临床表现与侧支循环的关系及其影响因素

    Institute of Scientific and Technical Information of China (English)

    王洪坤; 姜振泼; 宋玉强; 张拥波

    2013-01-01

    Objective To investigate the relationship between clinical manifestations and collateral circulation and its related factors in patients with internal carotid artery occlusion (ICAO).Methods 63 patients with ICAO were analyzed retrospectively.According to the clinical manifestations,all patients were divided into three groups:asymptomatic group(n =14),TIA group (n =4) and cerebral infarction group (n =45).According to the building of collateral circulation,all patients were divided into two groups:the better compensation group (n =42) and the poorer compensation group (n =21).According to cerebral infarction,all patients were divided into two groups:the cerebral infarction group (n =45) and no cerebral infarction group (n =18).CT angiography (CTA) and Transcranial Doppler (TCD) were used to evaluate collateral circulation and the risk factors.The relationship between clinical manifestations and collateral circulation and its related factors were discussed Results ①The opening of primary collateral pathways (AComA and PComA) had the most frequency of the three groups,the secondary collateral pathways(OA) was the second.No statistically significance was found among three groups.②The hyperlipidemia percentage and the high-sensitivity C-reactive protein(hs-CRP) level of the poorer compensation group were higher than those of the better compensation group(P < 0.05).③For coronary heart disease,cerebral infarction group was significantly lower than that of no cerebral infarction group (P < 0.05),but for hs-CRP,cerebral infarction group was significantly higher than that of no cerebral infarction group (P < 0.01).Conclusions There is no significant relativity between clinical manifestations and collateral circulation in patients with ICAO.Hyperlipidemia and inflammatory factor influence the establishment of collateral circulation and formation of cerebral infarction,which participate in the pathophysiological process of ICAO,so we should strengthen the control

  8. Investigating subjective attributes of quality for videos displayed with local backlight dimming

    DEFF Research Database (Denmark)

    Mantel, Claire; Bech, Søren; Forchhammer, Søren;

    2014-01-01

    This paper investigates what composes the quality of videos displayed on LCD with local backlight dimming. In a sub- jective experiment, participants assessed the level of nine attributes defined using the Qualitative Descriptive Anal- ysis method. Results show that three attributes (Contrast...

  9. Relationship between aryl hydrocarbon receptor interacting protein gene expression and clinical characteristics in human pituitary somatotrophinomas%人垂体生长激素腺瘤临床生化特征与芳香烃基受体相互作用蛋白基因表达的相关性

    Institute of Scientific and Technical Information of China (English)

    雷琢玮; 陈娟; 谢蕊繁; 李朝曦; 淦超; 徐钰; 叶飞; 孙玉洁; 韩晓

    2015-01-01

    Objective To investigate the expression of aryl Hydrocarbon Receptor Interacting protein (AIP) gene mutations and relationship with clinical biochemical characteristics in human somatotropinomas.Methods From October 2009 to September 2012,96 acromegaly or gigantism patients were diagnosed in a single pituitary center,with consistent treatment and follow-up.Genomic DNA from tumor tissues was extracted and sequenced.Clinical data were retrospectively analyzed.Results Overall,55 patients (57.3%) had one or more single base substitutions inAIP gene from their tumor tissues.Thirteen point mutations were detected in total,and 5 novel ones (c.609C > G,c.646-38C > T,c.646-35C > T,c.646-34A > T and c.692C > T) were firstly reported according to the National Center for Biotechnology Information (NCBI) single nucleotide polymorphism (SNP) database.Somatic AIPmut group showed characteristics as younger onset age (P < 0.05),larger tumor diameter (P < 0.05),higher invasiveness and aggressiveness (P < 0.05),and more prevalence in recurrent tumors (P < 0.05),than the negative group.Conclusion Somatic AIP gene mutation screen may be clinically crucial for the substantial treatment and outcome prejudgement,as well as the follow-up duration and frequency.The treatment strategy for AIPmut patients remains stressful; in the meanwhile,the role of AIP gene in the pathogenesis of somatotropinomas await more investigation.%目的 探讨芳香烃基受体相互作用蛋白(AIP)基因在国人垂体生长激素腺瘤中的体细胞突变与临床生化特征相关性.方法 收集96例垂体生长激素腺瘤患者的肿瘤标本进行检测,分析临床随访资料.结果 在对55例(57.3%)肿瘤标本中测序发现13个突变位点,其中,c.609C >G,c.646-38C>T,c.646-35C>T,c.646-34A>T和c.692C>T 5种类型尚未在国家生物技术信息中心(NCBI)单核苷酸多态性(SNP)数据库中报道过,为新发现AIP基因突变位点.AIP基因突变与患者起

  10. Correlative Analysis of the Relationships and Differences on D-dimer, Fibrinogen and Antithrombin Ⅲ Between Varied Clinical Periods of Cerebral Infarction%D-D、Fb和AT-Ⅲ在脑梗死不同时期的变化及相关性分析

    Institute of Scientific and Technical Information of China (English)

    徐威香; 武蓉珍; 胡晓蕾

    2012-01-01

    目的:探讨血浆D-二聚体(D-D)、纤维蛋白原(Fb)和抗凝血酶Ⅲ(AT-Ⅲ)在脑梗死(CI)不同时期的变化及其临床意义.方法:根据临床特征,对260例CI患者进行分组,其中CI急性期组80例、进展期组41例、非进展期组65例、康复期组74例;90例体检健康者为正常对照组.采用SYSMEX CA7000血凝仪分别检测其血浆D-D、Fb和AT-Ⅲ水平.结果:CI急性期、进展期、非进展期患者D-D、Fb含量均明显高于正常对照组(P<0.01),AT-Ⅲ低于正常对照组(P<0.01);脑梗死组中,D-D与AT-Ⅲ呈负相关(P<0.01),D-D与Fb呈正相关(P<0.01),AT-Ⅲ与Fb无相关性.结论:CI患者D-D、Fb、AT-Ⅲ变化显著,D-D升高伴随AT-Ⅲ含量降低,提示D-D、Fb、AT-Ⅲ共同参与了梗死发生发展的病理生理过程,可作为CI临床危险分级和病情监测的指标.%Objective To investigate the differences and its clinical significance of D-dimer, fibrinogen and antithrombin Ⅲ between varied clinical periods of cerebral infarction( CI). Methods 328 CI patients were rolled into the study, and they were divided into four groups due to their different clinical periods as follows: group acute period (80) , group progressing(41) , group non-pro-gressing(65) , group convalescence(74). And, 90 healthy volunteers were rolled into the normal control group. Their plasma D-dimer, fibrinogen and antithrombin HI were detected on SYSMEX CA7000 automatic coagulation analyzer. Results D-dimer and fibrinogen of CI patients in the acute, progressing and non-progressing periods were significantly higher (P <0.01) than those of healthy volunteers, while antithrombin Ⅲ of them was significantly lower (P<0.01) than that of healthy volunteers. In CI patients, D-dimer correlated negatively with antithrombin Ⅲ, while positively with fibrinogen. No significant relationship was observed between antithrombin Ⅲ and fibrinogen. ConclUSin D-dimer, fibrinogen and antithrombin Ⅲ of CI patients varied significantly

  11. Comparative Study of Relationship between Needle-retaining Time and Clinical Effect on Acupuncture Treatment of Lumbar Disc Herniation%针刺治疗腰椎间盘突出症时效关系的临床对比研究

    Institute of Scientific and Technical Information of China (English)

    侯学思; 王影; 白鹏; 何云龙; 王天识; 罗溪

    2015-01-01

    Objective:To compare the clinical effect on lumbar disc herniation( LDH) by different needle-re-taining time and explore the possible relationship between needle-retaining time and clinical effects.Methods:The study adopted randomized controlled experiment scheme.54 cases were randomly divided into three groups according to the inclusion order.The needle retaining time was respectively 15 minutes,30 minutes and 45mi -nutes with the same acupoints and acupuncture manipulation,10 times as a period.The McGill Pain Question-naire-short form,the Modified-Modified Schober( MMS) ,and the Chinese version of the Roland-morris Dis-ability Questionnaire( CRMDQ) were obseved before and after treatment.And the curative effect was estimated after treatment.Results:Before and after treatment in every group,the decline in Pain rating index( PRI) scores and Visual Analogue Scale( VAS) scores were significant ( P0.05).Conc lusion:Acupuncture treatment is an effective therapy for LDH which could alleviate pain and dysfunction syndrome.But it has not been proved that needle retaining time has an effect on clinical effect.To analyze the current trend, the total effect of groups with 30 min and 45 min nee-dle retaining is better than the group with 15 min.The current results may be related to small samples.%目的:对比不同留针时间针刺治疗腰椎间盘突出症的疗效,探究留针时间与疗效的关系。方法:采用随机对照试验方案,将符合纳入标准的54例患者按随机数表分为3组,各组均采用相同的穴位及针刺手法,分别留针15 min、30 min、45 min,10次为一疗程。观察指标包括:简式McGill疼痛量表、重复改良版Schober、中文版Roland-morris功能障碍量表,并进行疗效评估。结果:治疗前后组内比较,各组疼痛积分均显著减低(P<0.01)、关节活动度均显著提高(P<0.05)、功能障碍程度均显著降低(P<0.01);治疗后组间比较,上述

  12. Exploring Entrepreneurial Network Relationships

    DEFF Research Database (Denmark)

    Norus, Jesper

    2003-01-01

    the institutional and organizational origins are to be touched upon to come to understand the nature of the biotechnology environment and the actors involved. The positioning of the SBFs as the focal point of the analysis leads to a discussion on entrepreneurial business strategies in biotechnology industry and how...... theories and a dynamic view of network relations. That is done in order to capture the nature of the relationships between different types of actors, but also in order to emphasize the informal nature of some of these relationships.The article has a dual purpose; 1) From a corporate point of view...... to emphasize multiple conditions for developing and forming interorganizational relationships, 2) From a research perspective to point to the diversity and heterogeneity of these relations and thereby emphasizes the evolutionary nature of these relations and their relatedness to the overall strategies obtained...

  13. Internet mediated adolescent relationships

    Directory of Open Access Journals (Sweden)

    Fabrício de Souza

    2010-06-01

    Full Text Available This paper aims to contribute towards the comprehension of the adhesion of adolescent to digital technologies and their usage in the search for or consolidation of relationships with their peers. The objective was to analyze the role of blogs in the maintenance and establishment of relationships among adolescents from the State of Espírito Santo, Brazil. Three boys’ blogs and three girls’ blogs were selected, and five pages of each blog were selected, in a total of 30 pages. Categories were elaborated from reading the posts left at the 30 pages and subsequently used to classify and quantify the posts. Messages and comments left at the blogs had a positive affective connotation, in search for approximation and contact with the blog owner. Messages were also noted for gender differences. It was concluded that some determined patterns of offline interaction guided the establishment of online relationships.

  14. Cross border relationships

    DEFF Research Database (Denmark)

    Singla, Rashmi; Sriram, Sujata

    2010-01-01

    in which they were born. These movements also imply human relationships across the borders in different contexts with various cultural, psychological consequences. Relationships of members of migrant groups with each other, and also with the host community have important implications on the health and well......-being of not just the migrant population, but also the host communities. These relationships represent the microcosm of societal and cultural integration and cohesion at the broader levels. Studies of how and how well migrants, especially youth handle migration indicate transformations in paradigms as both...... acculturative stress and developmental possibilities are realities experienced in the search of new worlds and new opportunities. The symposia will include such changes from Denmark, India, UK and the USA, covering theoretical, methodological issues including the ethical aspects. Themes involved in crossing...

  15. 儿童保健门诊患方在医患关系与信任方面认知的调查分析%Cognition investigation and analysis of doctor-patient relationship and trust in patients in child health clinic

    Institute of Scientific and Technical Information of China (English)

    王晶; 祁玉丽; 张卉; 童梅玲; 池霞

    2015-01-01

    目的 了解不同因素对患方在医患关系与信任方面的影响,并提出针对性的对策. 方法 采用简单随机抽样的调查方法,于2014年11月~2015年1月,在南京市某三甲医院儿童保健科门诊进行自制问卷调查,由调查者说明调查目的,征得儿童家长同意后,发放调查问卷,说明填写方法. 由家长填写问卷,调查者收集问卷,并对调查问卷的完整性和有效性进行核查. 共发放478份,经检核剔除无效问卷4份,回收有效问卷474份. 结果 70.9%的儿童家长认为目前医患关系好,25.3%的儿童家长认为目前医患关系一般,3.8%的儿童家长认为目前医患关系紧张;家庭月总收入、学历对家长在医患关系的认识方面,差异有统计学意义(P<0.05). 96.2%的家长信任医务人员,3.6%的家长对医务人员半信半疑,0.2%的家长表示不信任医务人员;就诊儿童年龄、学历在家长对医务人员信任方面差异有统计学意义(P<0.05). 结论 改善医患间的关系与信任,应针对不同人群,采取更为有效的沟通方式,共同创造良好的医患环境.%Objective To get known the influence of different factors on doctor-patient relationship and trust from the patients,and put forward to the targeted countermeasures. MethOds By simple random sampling,self-made questionnaire was used to surveyed in clinic in department of child health of a top three hospital in Nanjing from November 2014 to January 2015.After explaining the purpose by investigator and getting promotion from children's patients,questionnaire was delivered.How to fill in the questionnaire was told by investigator. After finishing the questionnaire and collecting these forms,the completeness and effectiveness of questionnaire were checked.There were 478 questionnaires delivered, and 4 ones were excluded due to invalidity after check,and the rest 474 ones were recruited. Results 70.9% of chil-dren's parents believed that the current doctor

  16. Organizational Relationship Termination Competence

    DEFF Research Database (Denmark)

    Ritter, Thomas; Geersbro, Jens

    2011-01-01

    termination are found to significantly affect a firm's relationship termination competence. The findings suggest that managers should regard termination as a legitimate option in customer relationship management. In order to decrease the number of unwanted customers, managers must accept termination...... of organizational termination in order to improve our understanding of the management of termination. The impact of these termination dimensions on the percentage of unwanted customers is developed and tested using PLS on data gathered from a cross-sectional survey of more than 800 sales representatives. We find...

  17. Internet mediated adolescent relationships

    OpenAIRE

    Fabrício de Souza; Maria Margarida Pereira Rodrigues

    2010-01-01

    This paper aims to contribute towards the comprehension of the adhesion of adolescent to digital technologies and their usage in the search for or consolidation of relationships with their peers. The objective was to analyze the role of blogs in the maintenance and establishment of relationships among adolescents from the State of Espírito Santo, Brazil. Three boys’ blogs and three girls’ blogs were selected, and five pages of each blog were selected, in a total of 30 pages. Categories were e...

  18. Human-Forest Relationships

    DEFF Research Database (Denmark)

    Ritter, Eva; Dauksta, D.

    2012-01-01

    with the same attention as the other functions. The aim of this paper is to put a stronger emphasis on the fact that the acknowledgement of cultural bonds is needed in the discussion of sustainable development. Forest should not only be considered as a technical means to solve environmental and economic......The relationship between human beings and forests has been important for the development of society. It is based on various productive, ecological, social and cultural functions of forests. The cultural functions, including the spiritual and symbolic role of forests, are often not addressed......, in addition to economic, ecological and social functions, and lead towards a sustainable relationship between forests and society....

  19. Need fulfillment in polyamorous relationships.

    Science.gov (United States)

    Mitchell, Melissa E; Bartholomew, Kim; Cobb, Rebecca J

    2014-01-01

    Polyamory is characterized by simultaneous consensual romantic relationships with multiple partners. Polyamory allows individuals to fulfill their relationship needs with multiple romantic partners, yet researchers have not identified how having needs met in one romantic relationship may be related to relationship outcomes in a concurrent relationship. Polyamorous individuals (N=1,093) completed online measures of need fulfillment, relationship satisfaction, and commitment for two concurrent romantic relationships. Participants reported high levels of need fulfillment and satisfaction in both relationships. Need fulfillment with one partner negatively predicted approximately 1% of the variance in relationship satisfaction with the other partner; however, there was no association between need fulfillment with one partner and commitment to the other. Generally, the findings suggest that polyamorous relationships are relatively independent of one another. This study provides initial evidence that polyamory may be a viable and fulfilling alternative way of conducting intimate relationships.

  20. Risk Management in the NHS: Governance, Finance and Clinical Risk

    OpenAIRE

    Fenn, Paul; Egan, Tom

    2012-01-01

    This paper explores this theme – the inter-relationship between good governance, financial incentives and clinical risk management – and presents evidence gleaned from views expressed by key decision takers within the NHS.

  1. Diasporic Relationships and Processes

    DEFF Research Database (Denmark)

    Singla, Rashmi

    2010-01-01

    How does moving across the geographical borders affect the relationships of diaspora members both here – in the country of residence and there- in the country of origin? The article delineates some of the processes through gendered experiences of the young adults perceived as active actors based...

  2. China-EU Relationship

    Institute of Scientific and Technical Information of China (English)

    Feng Zhongping; Zhang Yimeng

    2007-01-01

    @@ The China-EU relationship attracted global interest in 2006. On the one hand, cooperation between China and the EU was making good progress, but on the other, there were challenges facing both, leading some international policy analysts to conclude that the honeymoon period between China and the EU was over.

  3. Customer Relationship Management.

    Science.gov (United States)

    Fayerman, Michael

    2002-01-01

    Presents an approach increasingly employed by businesses to track and respond to their customers to provide better and faster services: customer relationship management. Discusses its applicability to the operations of higher education and institutional research and the role it plays in the knowledge management framework. (EV)

  4. Multi-Dimensional Relationship

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Relationships between China and Russia are set to reach new heights during the next two years with the advent of the Russian Year in China (2006) and the Chinese Year in Russia (2007). Russian Ambassador to China Sergey Razov shared his views with Beijing Review about this development in bilateral relations between the two giant neighbors.

  5. An ambiguous relationship

    DEFF Research Database (Denmark)

    Søndergaard Larsen, Lene; Hedegaard Larsen, Birte; Birkelund, Regner

    2013-01-01

    and volunteered participation. Typically, the social interaction was experienced as giving and was referred to in positive terms but recurrently, the opposite was experienced too. The ambiguity of the relationship clearly emerged in all of the synthesized themes presented in this article. Implications...

  6. An ambiguous relationship

    DEFF Research Database (Denmark)

    Andersen, Lene Søndergaard; Larsen, Birte Hedegaard; Birkelund, Regner

    2013-01-01

    . Typically, the social interaction was experienced as giving and was referred to in positive terms but recurrently, the opposite was experienced too. The ambiguity of the relationship clearly emerged in all of the synthesized themes presented in this article. Implications for practice: Hospitalized patients...

  7. Creating Good Relationships: Responsiveness, Relationship Quality, and Interpersonal Goals

    OpenAIRE

    Canevello, Amy; Crocker, Jennifer

    2010-01-01

    Perceived partner responsiveness is a core feature of close, satisfying relationships. But how does responsiveness originate? Can people create relationships characterized by high responsiveness, and consequently, higher quality relationships? We suggest that goals contribute to cycles of responsiveness between people, improving both people’s relationship quality. The present studies examine 1) how interpersonal goals initiate responsiveness processes in close relationships, 2) the self-perpe...

  8. 喉鳞癌患者外周血T淋巴细胞AgNORs表达与临床相关因素的分析%Argyrophilic nucleolar organizer regions expression in laryngeal squamous cell carcinoma and its & nbsp;relationship with clinical factors

    Institute of Scientific and Technical Information of China (English)

    门倩倩; 欧阳电; 丁卫泉; 苏旋; 杨安奎

    2013-01-01

    prognostic factor in pharynx cancer, multiple myeloma, male breast cancer and prostate cancer. This study aimed to examine the expression of AgNORs in laryngeal squamous cell carcinoma and analyze the relationship between the expression of AgNORs and clinical factors including age, gender, clinical stage, T stage, N stage, classification, histology grade, recurrence and incisal edge. Methods:Clinical information and the AgNORs count of 122 cases laryngeal squamous cell carcinoma patients, who were initially treated by surgery between 2001 and 2004, were collected. SPSS 16.0 software was used. Kaplan-Meier method was used for survival analysis, and log-rank test was used for data analysis;multivariate analysis was carried out using Cox proportional hazard model. Results: The positive AgNORs expression group (5-year overall survival rate:58%) had a worse prognosis than that of negative group (5-year overall survival rate:76%) (P<0.05). Age, clinical stage, T stage, N stage, classification, recurrence, incisal edge and AgNORs expression were the most important prognostic factors (P<0.05). The expression of AgNORs was correlated with clinical stage, T stage, recurrence and incisal edge (P<0.05). AgNORs expression was statistically significant differences on judging lymph node metastasis in the supraglottic laryngeal carcinoma, and it was related with recurrence in the patients of negative incisal edge. Age and recurrence were independent prognosis factors on survival in laryngeal squamous cell carcinoma patients. Conclusion:Postoperative active treatment may should be recommended for cases with AgNORs positively expressed and the incisal edge negative;and selective lymph node dissections may should be performed on supraglottic laryngeal squamous cell carcinoma with AgNORs positive patients.

  9. Masculinity in adolescent males' early romantic and sexual heterosexual relationships.

    Science.gov (United States)

    Bell, David L; Rosenberger, Joshua G; Ott, Mary A

    2015-05-01

    There is a need to understand better the complex interrelationship between the adoption of masculinity during adolescence and the development of early romantic and sexual relationships. The purpose of this study was to describe features of adolescent masculinity and how it is expressed in the contexts of early to middle adolescent males' romantic and sexual relationships. Thirty-three 14- to 16-year-old males were recruited from an adolescent clinic serving a community with high sexually transmitted infection rates and were asked open-ended questions about their relationships-how they developed, progressed, and ended. Participants described a high degree of relationally oriented beliefs and behaviors related to romantic and sexual relationships, such as a desire for intimacy and trust. The males also described a more limited degree of conventionally masculine beliefs and behaviors. These beliefs and behaviors often coexisted or overlapped. Implications for the clinical care of similar groups of adolescents are described.

  10. Cugini's syndrome: its clinical history and diagnosis

    Directory of Open Access Journals (Sweden)

    Laura Gasbarrone

    2013-09-01

    Full Text Available INTRODUCTION: This article deals with the description and diagnosis of a new nosographic syndrome, which received the eponym of "Cugini's syndrome" by the name of the Author who discovered its clinical picture. This syndrome is characterized by the binomial: "minimal target organ damage associated to monitoring prehypertension". CLINICAL HISTORY AND DIAGNOSIS: Between the years 1997 and 2002, the Author published a series of investigations regarding some office normotensives who inexplicably showed incipient signs of target organ damage (TOD. Investigated via ambulatory (A blood (B pressure (P monitoring (M, these subjects were surprisingly found not to be hypertensive. Neverthless, the office normotensives with TOD exibited the daily mean level of their systolic (S and diastolic (D BP (DML SBP/DBP significantly more elevated as compared to true normotensives. Because of these ABPM findings, the Author realized that the investigated subjects were false normotensives whose TOD was associated with a monitoring prehypertension (ABPM-diagnosable prehypertension alias monitoring prehypertension alias masked prehypertension. The year after the last Cugini's investigation, the INC-7 Reports introduced the term: "prehypertension" in its classification of arterial hypertension, as an office sphygmomanometric condition in between office normotension and office hypertension. The ABPM cut-off upper limits for a differential diagnosis between monitoring normotension, prehypertension and hypertension are reported, as calculated by the Author in its collection of ABPMs. The eponym of "Cugini's syndrome" was assigned in 2007 and confirmed in 2009. CONCLUSIVE REMARKS: The monitoring prehypertension is a further condition of discrepancy between office sphygmomanometry and ABPM, as per a masked prehypertension, whose diagnosis has to be immediately diagnosed, for preventing the onset of a TOD. There are reported the present investigations dealing with the possible

  11. Special Issue on Clinical Supervision: A Reflection

    Science.gov (United States)

    Bernard, Janine M.

    2010-01-01

    This special issue about clinical supervision offers an array of contributions with disparate insights into the supervision process. Using a synergy of supervision model, the articles are categorized as addressing the infrastructure required for adequate supervision, the relationship dynamics endemic to supervision, or the process of delivering…

  12. Relationship Marketing in Educational Services

    OpenAIRE

    Pariza - Manea Natalia

    2012-01-01

    This article aims to analyze the existence of relationship marketing in educational services. This type of marketing focuses on building a lasting relationship with the customer and continuous communication with it. Relationship marketing can focus on the university's relationship with the end consumer (companies that hire graduates) and other client organizations (schools, universities, research centers).

  13. Antecedents of Customer Relationship Termination

    DEFF Research Database (Denmark)

    Geersbro, Jens; Ritter, Thomas

    relationships as a managerial task. This paper contributes by (1) developing a conceptualization of relationship termination competence and (2) analyzing its antecedents. The empirical results identify termination acceptance, definition non-customers, organizational relationship termination routines......, and motivation as significant antecedents. Because of this, managers need to develop their organizations in order to use relationship termination as a vital strategy....

  14. Relationship Between Personality Types Conceptualized by C. G. Jung and Emotional Intelligence

    Directory of Open Access Journals (Sweden)

    Natasha Virmozelova

    2013-10-01

    Full Text Available The main aim of this study is to present the results from a study of the relationship between personality types described by C. G. Jung and emotional intelligence. The investigated subjects were 150 at the age of 18 – 50. The methods of research were MBTI (Myers-Briggs Type Indicator - Bulgarian adaptation (Rusinova, 1992 and one psychological questionnaire measuring emotional intelligence -Bulgarian adaptation (Stoyanova, 2008. The received data indicated that the functions of thinking and sensing, and introversion correlated inversely with the factors of emotional intelligence “Sharing emotions and empathy”, “Motivation to overcome difficulties and optimisms” and extroversion correlated proportionally with them. The function feeling correlated proportionally with the factor “Sharing emotions and empathy” and it correlated inversely with the factor “Recognition of nonverbal expression of emotion of the other people”.

  15. 膝骨关节炎患者临床症状与等速肌力测试指标的关系%Study on the relationship between clinical symptoms and isokinetic test indexes of myodynamia in patients with knee osteoarthritis

    Institute of Scientific and Technical Information of China (English)

    周文琪; 罗小兵; 王小勇; 虞亚明; 何栩; 高丕明; 蒋晴

    2014-01-01

    Objective:To explore the relationship between clinical symptoms and isokinetic myodynamia test indexes in patients with knee osteoarthritis(KOA). Methods:One hundred and twelve patients with KOA were enrolled in the study. Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)scores were assessed with guidance from three trained evaluation staff. Peek torque,relative peek torque,peek power and relative peek power of knee extensors and flexors at 60° / sec and 180° / sec were measured by using an ISOMED-2000 isokinetic dynamomete. Then spearman correlation analysis and multiple linear regression analysis were applied to study the relation-ship between WOMAC and isokinetic myodynamia test indexes. Results:The results of spearman correlation analysis showed that most inde-xes of WOMAC were negatively correlated with peek torque,relative peek torque,peek power and relative peek power at 60° / sec and 180° / sec of knee extensors(p 0. 05)and only a few indexes of WOMAC were negatively correlated with relative peek torque and relative peek power(p 0.05),仅有少部分临床症状指标与相对峰力矩、相对峰功呈负相关(p <0.05)。多重线性回归分析结果显示,60(°)·s ﹣1时的伸膝相对峰功与西安大略和麦克马斯特大学骨关节炎指数中的疼痛评分、僵硬评分、行动障碍评分及总分均存在负线性关系(r =﹣0.271,p =0.001;r =﹣0.308,p =0.000;r =﹣0.263,p =0.001;r =﹣0.296,p =0.000);180(°)·s ﹣1时的伸膝相对峰功与疼痛评分存在负线性关系(r =﹣0.214,p =0.010),180(°)·s ﹣1时的伸膝峰功与僵硬评分存在负线性关系( r =﹣0.202,p =0.015)。结论:在等速肌力测试指标中,伸膝指标对膝骨关节炎患者临床症状的影响大于屈膝指标,其中60(°)·s ﹣1时的伸膝相对峰功最能反映膝骨关节炎患者的临床症状,可将其作为定量评价膝骨关节炎患者临床症状的指标之一。

  16. Participating in Clinical Trials

    Medline Plus

    Full Text Available ... Participating in Clinical Trials: About Clinical Trials In This Topic About Clinical Trials Risks and Benefits Terms ... with Your Doctor Taking Medicines The information in this topic was provided by the National Library of ...

  17. Participating in Clinical Trials

    Medline Plus

    Full Text Available ... Participating in Clinical Trials About Clinical Trials A Research Study With Human Subjects A clinical trial is a research study that involves human subjects. The purpose of ...

  18. Participating in Clinical Trials

    Medline Plus

    Full Text Available ... Clinical Trials In This Topic About Clinical Trials Risks and Benefits Terms to Know Finding a Clinical ... researchers may gather information about experimental treatments, their risks, and how well they work compare existing therapies ...

  19. Participating in Clinical Trials

    Medline Plus

    Full Text Available Home > Health topics A-Z > Participating in Clinical Trials: About Clinical Trials In This Topic About Clinical Trials Risks ... centers across the country. The National Institutes of Health funds much of this basic research. Screening Trials ...

  20. Participating in Clinical Trials

    Medline Plus

    Full Text Available ... on. Participating in Clinical Trials About Clinical Trials A Research Study With Human Subjects A clinical trial is a research study that involves human subjects. The purpose ...

  1. Statistical literacy for clinical practitioners

    CERN Document Server

    Holmes, William H

    2014-01-01

    This textbook on statistics is written for students in medicine, epidemiology, and public health. It builds on the important role evidence-based medicine now plays in the clinical practice of physicians, physician assistants and allied health practitioners. By bringing research design and statistics to the fore, this book can integrate these skills into the curricula of professional programs. Students, particularly practitioners-in-training, will learn statistical skills that are required of today’s clinicians. Practice problems at the end of each chapter and downloadable data sets provided by the authors ensure readers get practical experience that they can then apply to their own work.  Topics covered include:   Functions of Statistics in Clinical Research Common Study Designs Describing Distributions of Categorical and Quantitative Variables Confidence Intervals and Hypothesis Testing Documenting Relationships in Categorical and Quantitative Data Assessing Screening and Diagnostic Tests Comparing Mean...

  2. Positive interventions in clinical practice.

    Science.gov (United States)

    Rashid, Tayyab

    2009-05-01

    Mainstream psychotherapy has made huge strides in treating symptoms and disorders, but it has largely overlooked happiness as a therapeutic goal despite frequently hearing from clients, "Doctor, I want to be happy." This issue of Journal of Clinical Psychology: In Session describes a number of positive interventions for specific clinical problems, such as depression, anxiety, schizophrenia, loss, grief, and relationship distress. Although the name may suggest it, positive interventions do not imply that rest of psychotherapies are negative. Neither are negatives denied nor minimized. Distinct from self-help recipes proffering instant changes, positive psychology interventions refer to systematic approaches to overcome challenges by using clients' strengths and assets. A hybrid psychotherapy-coaching model and strength-based assessment can ask a client "What is right with you?" All articles are supplemented with rich case illustrations. PMID:19294745

  3. 精神分裂症患者富马酸喹硫平血浓度测定及血浓度疗效关系%Relationship among serum concentrations, doses and clinical responses of quetiapine fumarate in patients with schizophrenia

    Institute of Scientific and Technical Information of China (English)

    郭瑞臣; 傅崇铭

    2003-01-01

    To establish a method for determination of serum concentrations of quetiapine fumarate in patients with schizophrenia of different doses and to study its relationship with clinical response. METHODS: A HPLC method was used to determine serum concentrations of quetiapine fumarate in 76 patients with schizophrenia before or after 2, 4, 6-week treatment and its therapeutic efficacies were measured by BPRS. RESULTS: The standard curve was linear within the concentration range of 0.05-0.5 mg*L-1 of quetiapine fumarate in serum (r=0.9850). The serum concentrations of quetiapine fumarate were proportionally increased with the daily dose of 50-450 mg, but there was no significant correlation with age and sex. The optimal range estimated was 0.126-0.350 mg*L-1. CONCLUSION: The assay is simple, precise and suitable for therapeutic monitoring of quetiapine fumarate and the optimal concentration window is 0.126-0.350 mg*L-1 in treatment of patients with schizophrenia.%目的:建立反相高效液相色谱法测定精神分裂症患者富马酸喹硫平血浓度的方法学,探讨其血浓度与患者年龄、性别、服药剂量及临床疗效的关系.方法:采用高效液相色谱法测定76例单一服用富马酸喹硫平的精神分裂症住院患者治疗前及治疗后第2、4、6 wk 肘静脉血浓度,并进行BPRS量表评定及相关性分析.结果:富马酸喹硫平血浓度在 0.05~0.5 mg*L-1范围内有良好线性关系(r=0.9850).日剂量50~450 mg 时血浓度随剂量增大而升高,但与服药患者年龄、性别无显著相关性.血浓度在 0.126~0.350 mg*L-1范围内临床效果较好.结论:测定方法简便、准确、专一性强,可用于富马酸喹硫平治疗药物监测.治疗窗浓度为 0.126~0.350 mg*L-1.

  4. The Clinical Study of the Relationship between Changes of QRS Amplitude in the Treadmill Test and Alterations of the Coronary Artery Lesions%运动试验中QRS振幅变化与冠状动脉病变的关系

    Institute of Scientific and Technical Information of China (English)

    常峪文; 李娜; 贾莉; 李荣; 滕化民

    2011-01-01

    目的 了解运动试验中QRS振幅变化与冠状动脉病变的关系.方法 以冠状动脉造影结果将患者分为异常25例和正常15例两组.分析和比较QRS振幅在运动试验结束时与运动开始前的变化特点.结果 ∑QRS在运动试验结束时较运动开始前减少>5 mm,在异常组的25例中有17例、在正常组的15例中有5例.其变化对冠状动脉病变的敏感度为77 %,特异度为56%.两组例数之间的比较,差异有统计学意义(χ2= 4.55,P=0.03).结论 运动试验结束时∑QRS较运动前减少>5 mm,对冠状动脉病变的诊断有一定的参考价值.%Objective To investigate the clinical significance by the study of the relationship between changes of QRS amplitude in the treadmill test and alterations of the coronary artery lesions. Methods All patients were divided into two groups:Coronary artery was normal( 15 ) and abnormal( 25 ) through coronary arteriography( CAG ). The characteristics of QRS amplitude through the fore-and-aft treadmill test were analyzed and compared. Results The ∑ QRS decreased after treadmill test exceeds 5 mm. In the results of CAG were abnormal with 17 patients, and in the results of CAG were normal with 5 patients. The sensitivity of the QRS amplitude variation diagnosing coronary heart disease was 77%. The specificity was 56%. The differences were statistically significant betweent the two group ( x2 = 4.55,P = 0.03 ). Conclusion The ∑ QRS decreased after treadmill test exceeds 5 mm was a predictor of coronary artery lesions.

  5. Educational climate seems unrelated to leadership skills of clinical consultants responsible of postgraduate medical education in clinical departments

    OpenAIRE

    Scherpbier Albert JJ; Mortensen Lene S; Malling Bente; Ringsted Charlotte

    2010-01-01

    Abstract Background The educational climate is crucial in postgraduate medical education. Although leaders are in the position to influence the educational climate, the relationship between leadership skills and educational climate is unknown. This study investigates the relationship between the educational climate in clinical departments and the leadership skills of clinical consultants responsible for education. Methods The study was a trans-sectional correlation study. The educational clim...

  6. Relationship between the positive rates of the results of the tumor markers six of esopha-geal carcinoma preoperativly and the esophageal clinical parameters postoperativly%食管癌术前血浆肿瘤标志物检测的临床意义

    Institute of Scientific and Technical Information of China (English)

    孙宝林; 余守强; 甄福喜

    2016-01-01

    目的:探讨术前检测食管癌血浆六项肿瘤标志物的临床意义。方法:回顾手术治疗的食管癌临床资料138例,分析术前 NSE、AFP、CEA、CA72-4、CA19-9、C19六项肿瘤标志物与术后病理特征的关系。结果:138例患者年龄43~81(63.46±6.787)岁,男105例,女33例;鳞癌114例,腺癌24例;位于贲门16例;六项肿瘤标志物含量最高者为 NSE 占26.1%(36/138),最低者为 CA19-9占2.2%(3/138)。食管鳞癌中 NSE阳性率高;食管腺癌、贲门癌中 AFP、CEA 阳性率高,CA72-4阳性率在 Tis -T2组中升高,均有统计学意义;而 CA19-9和 C19阳性率在各病例组均无显著增高。结论:六项肿瘤标志物在食管癌患者术前血浆中阳性率较低。仅显示 AFP、CEA 在食管腺癌、贲门癌中,CA72-4在 Tis -T2期中,NSE 在食管鳞癌略高。%Objective:To investigate the clinical application value of the preoperative levels of six tumor markers for patients with esophageal cancer underwent esophagogectomy.Methods:The records of 138 cases with esophageal cancer underwent esophagogectomy were reviewed and the relationship between the results of preoperative esophageal six tumor markers and the pathological characteristics after esophagectomy was assessed.Results:The characteristics of 138 caes were as follow:Aged 43 ~81(63.46 ±6.787),105 male and 33 female,114 cases of squamous carcino-ma,24 cases of adenocarcinoma and 16 cases of cardia carcinoma.The positive rate of NSE was 26.1%(36 /138),the highest rate in six tumor markers and CA19 -9 was only 2.2%(3 /138),the lowest.The positive rate of AFP in the lower esophagus and cardia cancer and adenocarcinoma group,CEA in the esophageal adenocarcinoma group,CA72-4 in Tis -T2 group and NSE in the esophageal squamous cell carcinoma group was statistically increased (P<0.05).Whereas,the CA19 -9 and C19 in each group had no statistical significance

  7. A dimensão regulatória da Psicologia clínica: o impacto da racionalidade dominante nas relações terapêuticas The regulatory dimension of clinical psychology: the impact of the dominant rationality in therapeutic relationships

    Directory of Open Access Journals (Sweden)

    Maurício da Silva Neubern

    2005-04-01

    Full Text Available O projeto de se submeter, de diferentes modos, ao paradigma dominante na ciência produziu uma considerável dimensão regulatória da psicologia clínica que coincidiu com diversos momentos de exclusão da subjetividade. Esse enfoque é baseado, em termos gerais, sobre três problemas. Primeiramente, há o problema da legitimidade, segundo o qual, em função de um conhecimento pretensamente confiável e de noções universalistas, os sentidos singulares dos pacientes seriam substituídos por noções consagradas pelas teorias. O segundo problema é o da competência em que as teorias clínicas estariam muito mais imbuídas de noções voltadas à doença, ao déficit e à incapacidade, o que permitiria poucas opções quanto aos eventuais recursos dos pacientes. O terceiro problema seria o do consumo, no qual a ausência de uma discussão crítica sobre o mesmo permitiria a criação de uma cultura em que tanto os serviços quanto o conhecimento seriam consumidos como produtos. O artigo é concluído com o esboço de alguns pontos rumo a uma ética interna que possa estabelecer as relações entre as dimensões separadas no conhecimento e melhor refletir as conseqüências deste na sociedade.This work shows that the project of submitting oneself in different ways to the dominant paradigm in science has produced a considerable regulatory dimension of clinical psychology that has coincided with various moments of subjectivity exclusion. Such focus is in general terms based on three problems. Firstly, there is the problem of legitimacy, which states that due to a pretentiously trustful knowledge and to universalistic notions, patients' singular senses would be substituted with notions once successfully recognized by theories. The second problem is the competence in which the clinical theories would be a lot more empowered with notions regarding sickness, deficit, and incapacity, which would allow for few options in relation to occasional retreat

  8. The clinical study of relationship among different bundle bronch conduction with Doppler echocardiography ventricular arrhythmia in dilated cardiomyopathy%扩张型心肌病束支传导阻滞与心脏多普勒 超声指标、室性心律失常相关关系的研究

    Institute of Scientific and Technical Information of China (English)

    吴敏; 马守国; 曹玉珍; 张效东; 南静; 尹军; 袁慧敏; 石文芳

    2001-01-01

    Objective To study the relationship among different bundle bronch conduction with Doppler echocardiography,ventricular arrhythmia(VA) and other clinical materials in dilated cardiomyopathy(DCM).Methods 140 patients were divided into five groups according to different bundle bronch conduction in 12-leads electrocardiograme(groups CLBBB,CRBBB,CRBBB+LAFB,LAFB and normal bundle bronch conduction NBBC).By receivel clinical materials and measured parameters of Doppler echocardiography,24 hours ambulatory electrocardiograme before drug treatment in every group.The correlation between these data were assessed.Results Using statistic analyses showed that among different bundle bronch conduction groups in patients with DCM,the sick duration,the NYHA functional class,the heart thorax ratio,ther LV end-diastotic and end -systolic volume,the LV ejection fraction,the peak E velocity,E/A ratio and above I owns Ⅱ degree VA in groups CLBBB,CRBBB,CRBBB+LAFB were more serious than those in groups LAFB and NBBC.Conclusion Our data provide relevant information among different bundle bronch conduction groups,CLBBB、 CRBBB and CRBBB+LAFB are associated with the risk parameters of Doppler echocardiography,ventricular arrhythmia.%目的探讨扩张型心肌病(DCM)病人束支传导功能状态与心脏多普勒超声指标、室性心律失常的关系。方法根据140例DCM病人十二导体表心电图表现分为束支传导功能异常和束支传导功能正常5组,采集临床资料和心脏多普勒超声显像、24 h动态心电图、X线心脏摄片等检查结果进行组间统计学处理,评价束支传导功能状态与心脏多普勒超声指标、室性心律失常及其它临床指标的关系。结果 DCM束支传导异常组(CLBBB、CRBBB、CRBBB+LAFB)较束支传导功能正常组和单纯LAFB组NYHA心功能分级、X线心胸比、病程年限、心脏多普勒超声指标、Lown氏Ⅲ级以上室性心律失常发生率有显著统计学差异。

  9. 非临床群体思想融合信念、元认知和强迫症状的关系%Study on the Relationship among Thought Fusion beliefs,Meta-cognitions and Obsessive Compulsive Disorder in Non-clinical Population

    Institute of Scientific and Technical Information of China (English)

    张樱樱; 童辉杰

    2015-01-01

    Objective:The aim of the study was to explore the relationship among fusion beliefs ,meta-cognitions and obsessive -compulsive symptoms in the non -clinical population .Methods:456 partici-pants were tested through the using of Thought -Fusion Instrument ( TFI ) , Meta -cognitions Question-naire-30 ( MCQ-30 ) and Padua Inventory ( PI ) .Data was analyzed by using Pearson correlation and multiple regression analysis .Results:Thought-fusion beliefs ,meta-cognitive beliefs were positively cor-related with obsessive -compulsive symptoms ( r=0.354 -0.468,P<0.01).There were also positive correlations between subscales of thought -fusion beliefs and meta -cognitive beliefs and obsessive -compulsive symptoms(r=0.207~0.395,P<0.01).In regression analysis,Thought -Action Fusion, negative beliefs of worry ,Thought-Object Fusion and cognitive confidence entered into regression equa-tion.They could explain 26 .9% variation of the obsessive -compulsive symptoms .Conclusion:The thought fusion beliefs and meta -cognitions have significant predictive effect on obsessive -compulsive symptoms in the non-clinical group .The results support the meta -cognitive model of obsessive -com-pulsive disorder .%目的:探讨非临床群体思想融合、元认知与强迫症状之间的关系。方法:选取456名被试采用思想融合问卷( TFI)、元认知问卷( MCQ)和帕多瓦量表( PI)进行评定,对数据进行皮尔逊相关和多元回归分析。结果:思想融合信念、元认知信念与强迫症状存在显著性正相关(r=0.354~0.468,P<0.01);其中,思想融合各个因子、元认知各个因子与强迫症状也存在显著性正相关(r=0.207~0.395,P<0.01);回归分析中,思想-行为融合、担忧的消极信念、思想-客体融合与认知自信4个因子进入回归方程,能解释强迫症状26.9%的变化。结论:非临床群体的思想融合信念、元认知对强迫症状有显著

  10. 颈内动脉狭窄或闭塞患者侧支循环开放与临床表现的关系%Relationship between opening of collateral circulation and clinical manifestations in patients with stenosis or occlusion of ICA

    Institute of Scientific and Technical Information of China (English)

    李锦; 袁栋才; 张俊领; 王佳《中文作者六》=吴丹丹《中文作者六》=李玉妹

    2011-01-01

    Objective To analyze the relationship between opening of the collateral circulation and clinical manifestations during stenosis or occlusion of internal carotid artery. Methods Eighty-six patients with stenosis or occlusion of internal carotid artery detected by transcranial Doppler (TCD) and checked by digital subtraction angiography were selected. The patients were divided into four groups according to the opening situation of the collateral circulation:the group of opening 3 collateral circulation (Group l),the group of opening anterior or posterior communicating collateral circulation (Group 2), the group of opening ophthalmic artery collateral circulation (Group 3) ,the group of no collateral circulation opening (Group 4). The situation of opening of collateral circulation in each group was analyzed and compared. Results Compared with the symptoms of opening collateral circulation of ophthalmic artery,the symptoms of opening anterior communicating artery and posterior communicating artery were milder and prognosis was better. Conclusion TCD measures the collateral circulation of stenosis or occlusion of internal carotid artery sensitively and specifically. The situation of opening of collateral circulation is closely related with prognosis. The evaluation of collateral circulation has important clinical significance.%摘要:目的 分析颈内动脉严重狭窄或闭塞时,侧支循环开放与临床的关系.方法 选择经颅多普勒超声检测颈内动脉严重狭窄或闭塞、再经数字减影血管造影检查证实的患者86例,根据侧支循环开放情况分为4组:前交通、后交通和眼动脉侧支循环开放组(Ⅰ组)17例,前交通或后交通动脉侧支循环开放组(Ⅱ组)27例,眼动脉侧支循环开放组(Ⅲ组)28例,无侧支循环开放组(Ⅳ组)14例.分析各组患者侧支循环开放情况并进行比较.结果 86例患者共检出阳性侧支循环139条,前交通动脉侧支循环开放57条,占41.0

  11. Pain frequency moderates the relationship between pain catastrophizing and pain

    Science.gov (United States)

    Kjøgx, Heidi; Zachariae, Robert; Pfeiffer-Jensen, Mogens; Kasch, Helge; Svensson, Peter; Jensen, Troels S.; Vase, Lene

    2014-01-01

    Background: Pain frequency has been shown to influence sensitization, psychological distress, and pain modulation. The present study examined if pain frequency moderates the relationship between pain catastrophizing and pain. Method: A non-clinical (247 students) and a clinical (223 pain patients) sample completed the Danish versions of the Pain Catastrophizing Scale (PCS), Beck Depression Inventory, and the State Trait Anxiety Inventory and rated pain intensity, unpleasantness and frequency. Results: In both samples, high pain frequency was found to moderate the association between pain catastrophizing and pain intensity, whereas low pain frequency did not. The psychometric properties and the factor structure of the Danish version of the PCS were confirmed. Conclusions: This is the first study to validate the Danish version of the PCS and to show that pain frequency moderates the relationship between pain catastrophizing and reported pain in both non-clinical and clinical populations. PMID:25646089

  12. Pain frequency moderates the relationship between pain catastrophizing and pain

    Directory of Open Access Journals (Sweden)

    Heidi eKjøgx

    2014-12-01

    Full Text Available Background Pain frequency has been shown to influence sensitization, psychological distress and pain modulation. The present study examined if pain frequency moderates the relationship between pain catastrophizing and pain. Method A non-clinical (247 students and a clinical (223 pain patients sample completed the Danish versions of the Pain Catastrophizing Scale, Beck Depression Inventory and the State Trait Anxiety Inventory and rated pain intensity, unpleasantness and frequency Results In both samples, high pain frequency was found to moderate the association between pain catastrophizing and pain intensity, whereas low pain frequency did not. The psychometric properties and the factor structure of the Danish version of the PCS were confirmed.Conclusions This is the first study to validate the Danish version of the PCS and to show that pain frequency moderates the relationship between pain catastrophizing and reported pain in both non-clinical and clinical populations.

  13. Relationship Maintenance on Facebook: Development of a Measure, Relationship to General Maintenance, and Relationship Satisfaction

    Science.gov (United States)

    Dainton, Marianne

    2013-01-01

    Previous research indicates that the primary reason college students use Facebook is for relationship maintenance. The present study sought to determine the relationship between Facebook maintenance and general maintenance efforts in college student romantic relationships, as well as the impacts of such behaviors on the relationship. Survey data…

  14. Etiological relationships in atopy

    DEFF Research Database (Denmark)

    Thomsen, Simon Francis; Kyvik, Kirsten Ohm; Backer, Vibeke

    2008-01-01

    The genetics of asthma and atopy has been studied frequently in twin populations from various parts of the world. However, emphasis has been put on univariate analysis of questionnaire data, whereas clinical and intermediate traits only sporadically have been studied, especially in multivariate s...

  15. Future requirements. Clinical investigations

    DEFF Research Database (Denmark)

    Qvist, V.

    2002-01-01

    Biocompatability, Cariology, Clinical trials, Dental materials, Helath services research, Human, Pedodontics......Biocompatability, Cariology, Clinical trials, Dental materials, Helath services research, Human, Pedodontics...

  16. Relationship between serum concentration and clinical efficacy of aripiprazole in the treatment of patients with schizophrenia%阿立派唑治疗精神分裂症的血药浓度与临床效应关系研究

    Institute of Scientific and Technical Information of China (English)

    李建华; 钟华; 沈卫民; 孙菊水; 陈海支; 范振国; 卢桂华

    2011-01-01

    目的:研究阿立哌唑治疗精神分裂症的血药浓度与临床效应之间关系,探索阿立哌唑血药浓度的治疗窗.方法:采用前瞻性研究方法,应用非固定剂量药物治疗8周.以高效液相色谱仪测定阿立哌唑的谷浓度,阳性和阴性症状量表(PANSS),临床总体印象-病情严重程度量表(CGI-SI)评定疗效,治疗时出现的症状量表(TESS)评定不良反应.采用受试者运筹特征曲线(ROC曲线)获得血药浓度的最佳截断值,结合四分位间距法推测阿立哌唑血药浓度的治疗窗.并分析血药浓度与药物剂量、临床疗效、不良反应等之间的相关性.结果:入组80例患者,治疗有效47例、无效29例,另外4例脱落.总的不良反应发生率为32.5%.阿立哌唑血药浓度与药物剂量、PANSS减分率及TESS分值间呈正相关,与CGI-SI分值呈负相关.药物剂量与疗效无相关性.最低有效血药浓度为363 μg/L,发生不良反应的血药浓度阈值为540 μg/L.有效组血药浓度的四分位间距为348~623 μg/L.血药浓度在350~540 μg/L的范围内疗效较好,副反应较轻.结论:阿立哌唑治疗精神分裂症的血药浓度与临床效应之间存在相关性,较适宜的治疗窗是350~540 μg/L.%AIM: To explore the relationship between serum concentration and clinical efficacy of aripiprazole in the treatment of patients with schizophrenia, and the suitable therapeutic window of aripiprazole. METHODS: Prospective study method was adopted. The dosages of aripiprazole were unfixed for eight weeks. The trough serum concentrations were determined by high performance liquid chromatography (HPLC). The clinical efficacy was evaluated with the Positive and Negative Syndrome Scale (PANSS) and the Clinical Global Impression-Severity of Illnes (CGI-SI), side effects were done with the Treatment Emergent Symptom Scale (TESS). The optimized cutoff value of serum concentration was procured by the receiver operator curve (ROC), and the

  17. Relationship between CD44,CD133 + cells expression and clinical characteristics in breast cancer%乳腺癌中 CD44、CD133+细胞表达及其与临床特征相关性研究

    Institute of Scientific and Technical Information of China (English)

    张子杰

    2014-01-01

    Objective To investigate the relationship between CD44,CD133 + cells expression and clinical characteristics in breast canc-er,which would provide basis for clinical diagnosis and treatment,prognosis. Methods The pathology specimens of 200 cases of breast(25 cases of breast hyperplasia,22 cases of atypical hyperplasia,153 cases of breast cancer)and 30 cases of normal breast tissue were included as the study subject. The CD44,CD133 + expression in different breast lesions were detected by immunohistochemical staining. The expression of CD44, CD133 + in different clinical and pathological characteristics of breast cancer were analyzed. Results The positive expression rate of CD44、CD133 + in breast cancer were both significantly higher than those of breast hyperplasia,atypical hyperplasia( P ﹤ 0. 05). The dual expression rate of CD133 + ,CD44 in breast cancer,breast Hyperplasia,atypical hyperplasia was 58. 2% ,32. 0% ,18. 2%( P = 0. 00),respectively. The expression level of CD44,CD133 + increased with histological grade,TNM staging increasing( P ﹤ 0. 05). The expression level of CD44 CD133 + in recurrent breast cancer was significantly higher than that in non recurrent breast cancer( P ﹤ 0. 05). Conclusion There was some correlation between expression levels of CD44,CD133 + and clinical pathological characteristics of breast cancer. Therefore,a combined analysis of CD44,CD133 + expression is useful for evaluation of malignant degree and prognosis of breast cancer,which can be a direction in study of breast cancer therapy.%目的:探讨乳腺癌中 CD44、CD133+细胞表达与临床特征的相关性,为临床诊治、预后评估提供依据。方法收集乳腺病理标本200例(乳腺增生25例,不典型增生22例,乳腺癌153例)及正常乳腺组织30例。采用免疫组织化学染色测定乳腺不同病变组织中的 CD44、CD133+表达情况,分析乳腺癌不同临床病理特征的 CD44、CD133+表达水平。结果 CD44、CD133+

  18. 颈内动脉重度狭窄或闭塞患者颅内侧支循环与临床表现的关系%Relationship between collateral circulation and clinical manifestation after severe stenosis or occlusion of in- ternal carotid artery

    Institute of Scientific and Technical Information of China (English)

    朱惠萍; 李常红; 杜志华; 房艳玲; 于逢春

    2013-01-01

    Objective To explore the relationship between collateral circulation and clinical manifestation after se-vere stenosis or occlusion of internal carotid artery. Methods According to the clinical manifestation, 78 cases of ICA ste-nosis or occlusion confirmed by digital subtraction angiography (DSA) were divided into two groups:asymptomatic group (n=31) and symptomatic group (n=47). Collateral circulation pathway in circle of Willis and the mean flow velocity of the middle cerebral arteries (MVMCA) were measured by Transcranial Doppler Ultrasonography (TCD). The correlation of the types of intracranial collateral circulation and clinical manifestation was analyzed. Results ① The collateral circulation opening rate of severe stenosis or occlusion of internal carotid artery in 78 cases of patients was 70.5%(55/78). The collat-eral patency rate (27/31, 87.1% of patients) was higher in asymptomatic group than in the symptomatic group (28/47, 59.6%of patients)(P<0.01).②Collateral patency of anterior communicating artery (ACoA)in asymptomatic group (24/31, 77.4%of patients) was higher than that in symptomatic group (20/47, 42.6%of patients) (P<0.01). Collateral patency of ophthalmic artery (OA) in symptomatic group (21/47, 44.7%of patients) was higher than that in asymptomatic group(6/31, 19.4%of patients)(P<0.05). The opening rate of ACoA was significantly higher than that of either the posterior commu-nicating artery (PCoA) or OA collateral circulation in asymptomatic group (P<0.05).③The mean flow velocity of the af- fected side middle cerebral arteries (MVMCA) in asymptomatic group (51.58±12.36cm/s) was significantly higher than that in symptomatic group (32.23±10.31cm/s) (P<0.01). Conclusion The clinical manifestation is closely related to arterial circle of Willis collateral circulation opening after severe stenosis or occlusion of internal carotid artery and collateral patency of anterior communicating artery is the major collateral supply vessel.%

  19. Establishing effective working relationships.

    Science.gov (United States)

    Houghton, Trish

    2016-02-24

    This article, the second in a series of 11, provides support and offers advice to new and existing mentors and practice teachers to enable them to progress in their role and develop a portfolio of evidence. In particular, the article discusses how to establish effective working relationships and emphasises the importance of the student-mentor or student-practice teacher relationship. It examines the essential qualities, attributes and characteristics of an effective mentor or practice teacher. The article provides learning activities and suggests ways in which mentors and practice teachers can undertake various self-assessments, enabling them to gather relevant evidence to demonstrate how they can meet and maintain the requirements for these roles as stipulated by the Nursing and Midwifery Council.

  20. Probability distribution relationships

    Directory of Open Access Journals (Sweden)

    Yousry Abdelkader

    2013-05-01

    Full Text Available In this paper, we are interesting to show the most famous distributions and their relations to the other distributions in collected diagrams. Four diagrams are sketched as networks. The first one is concerned to the continuous distributions and their relations. The second one presents the discrete distributions. The third diagram is depicted the famous limiting distributions. Finally, the Balakrishnan skew-normal density and its relationship with the other distributions are shown in the fourth diagram.