WorldWideScience

Sample records for clinical hold oversight

  1. Barriers to Effective Deliberation in Clinical Research Oversight.

    Science.gov (United States)

    Wenner, Danielle M

    2016-09-01

    Ethical oversight of clinical research is one of the primary means of ensuring that human subjects are protected from the natural bias of researchers and research institutions in favor of experimentation. At a minimum, effective oversight should ensure that risks are minimized and reasonable in relation to anticipated benefits, protect vulnerable subjects from potential coercion or undue influence, ensure full and informed consent, and promote the equitable distribution of the risks and benefits of research. Because these assessments often involve value judgments for which there are no agreed-upon objective standards, we rely on deliberative procedures thought to have the greatest likelihood of producing the right or best outcomes. Concerns about the potential for improperly functioning IRBs to waste scarce human and institutional resources and impede biomedical progress have motivated a surge in empirical research assessing their procedures and outcomes. Yet within this literature, there has been minimal attention paid to the social scientific evidence regarding how individuals and deliberating groups make decisions, nor how those data might inform IRB practice. This essay seeks to fill that gap, locating recent empirical data on IRB composition and process within the context of data regarding what I call "deliberative pathologies," or instances when deliberation fails to live up to one or more aspect of the deliberative ideal because of systematic biases in the ways participants interact. The paper goes on to make evidence-based recommendations to reduce the vulnerability of IRB deliberations to the kinds of pathologies discussed and indicate directions for future research.

  2. Clinical holding with children who display behaviours that challenge.

    Science.gov (United States)

    Page, Andrea; McDonnell, Andrew; Gayson, Charlotte; Moss, Fiona; Mohammed, Needa; Smith, Claire; Vanes, Nicola

    Nurses hold children to administer treatment, prevent treatment interference and undertake clinical assessments, which can sometimes be invasive, as part of their regular duties. Clinical holding ensures this treatment or assessment is carried out safely, however, it has been reported that there is little training available in this area. This article explores the prevalent clinical holding techniques used by nursing staff when caring for children with behaviours that challenge. As an initial insight into what the researchers hope will become a more in-depth 2-year study, this investigation looks to explore current practice when holding children and the factors influencing this. It is hoped that this will inform the development of a training package offered to nurses when caring for these children. Thirteen semi-structured interviews took place with a small group of nurses, which were given thematic analysis. The overarching themes influencing holding practice were the nursing role itself along with intrinsic and external factors.

  3. Significant alterations in reported clinical practice associated with increased oversight of organ transplant center performance.

    Science.gov (United States)

    Schold, Jesse D; Arrington, Charlotte J; Levine, Greg

    2010-09-01

    In the past several years, emphasis on quality metrics in the field of organ transplantation has increased significantly, largely because of the new conditions of participation issued by the Centers for Medicare and Medicaid Services. These regulations directly associate patients' outcomes and measured performance of centers with the distribution of public funding to institutions. Moreover, insurers and marketing ventures have used publicly available outcomes data from transplant centers for business decision making and advertisement purposes. We gave a 10-question survey to attendees of the Transplant Management Forum at the 2009 meeting of the United Network for Organ Sharing to ascertain how centers have responded to the increased oversight of performance. Of 63 responses, 55% indicated a low or near low performance rating at their center in the past 3 years. Respondents from low-performing centers were significantly more likely to indicate increased selection criteria for candidates (81% vs 38%, P = .001) and donors (77% vs 31%, P < .001) as well as alterations in clinical protocols (84% vs 52%, P = .007). Among respondents indicating lost insurance contracts (31%), these differences were also highly significant. Based on respondents' perceptions, outcomes of performance evaluations are associated with significant changes in clinical practice at transplant centers. The transplant community and policy makers should practice vigilance that performance evaluations and regulatory oversight do not inadvertently lead to diminished access to care among viable candidates or decreased transplant volume.

  4. 78 FR 48173 - Guidance for Industry on Oversight of Clinical Investigations-A Risk-Based Approach to Monitoring...

    Science.gov (United States)

    2013-08-07

    ... Investigations--A Risk-Based Approach to Monitoring; Availability AGENCY: Food and Drug Administration, HHS... guidance for industry entitled ``Oversight of Clinical Investigations--A Risk-Based Approach to Monitoring.'' This guidance assists sponsors in developing risk-based monitoring strategies and plans for...

  5. Clinical and Laboratory Findings of Patients with Breath Holding Spells

    Directory of Open Access Journals (Sweden)

    Özlem Özdemir

    2009-09-01

    Full Text Available Aim: The aim of this prospective study was to evaluate the clinical characteristics; physical findings, cardiological, hematological and neurological problems; treatment approaches; and the prognosis of children with breath holding spells.Materials and Method: Seventhy patients were included in this study. All patients were evaluated with detailed history and physical examination. Complete blood count, serum iron and iron binding capacity were studied; cardiological (telecardiography, electrocardiography, if necessary echocardiography and event recorder and neurological investigations (electroencephalography were done during the admission. Patients with iron deficiency anemia and iron deficiency were treated with ferrous sulphate orally. In patients with normal hematological values, no medication was used. After a two-month treatment period patients underwent control hematological evaluation. Frequency of the spells, age of disappearance of spells (defined as 6 months without spells, disappearance ratios between the three groups were compared. Results: The percentage of cyanotic, palloric and mixt type of breath holding spells of 70 patients included in the study were 67.1, 14.3 and 18.6, respectively. It was determined that psychogenic factors played a role in 77.1% of our patients. There were iron deficiency anemia in 39 (55.7%, iron deficiency in 12 (17.2% and normal hematological parameters in 19 (27.1% of 70 patients. The QTc values were normal in all of them. EEG’s were normal in 56 (80%, dysrhythmic in 11 (15.7% and pathologic in (4.3%. There was a positive family history of breath holding spells in 44.3% of those with breath holding spells. Conclusion: We determined that there was a correlation between the iron levels and the frequency of spells. The lower the iron levels the higher the frequency of spells. There was a dramatic decrease of 92% in spells with low doses of iron supplementation especially in the anemic group. (Journal of

  6. Clinical Efficacy of Piracetam on Breath Holding Spells in Children

    Directory of Open Access Journals (Sweden)

    F. Ashrafzadeh

    2004-07-01

    Full Text Available Breath holding spells (BHS is a type of syncope in children , most commonly encontered in the early years of life. Although these athacks don't damage the brain , if these are frequent or prolonged cause , parents frighten , so physician should intervent. In this study we evaluated clinical efficacy of piracetam on B.H.S of children in Mashhad Ghaem Hospital during 2001-2002.In this double blind placebo control study , piracetam or placebo on a randomized basis was administered to children with 40 mg/kg/day in 2 divided doses for 2 months. From the 41 children that were enrolled , 21 cases received piracetam and 20 cases received placebo. Parents denoted the numbers of spells two months before and two months after taking drug. Control of breath holding spells were observed in 90.5% of patients in the group taking piracetam as compared with 40% in the group taking placebo (P = 0.002. Of the all patients 10 cases had iron deficiency anemia so they had taken elemental Fe too. The side effects were the same in these two groups. The results of this study indicated that piracetam was efficient for the treatment of children with B.H.S without greater incidence adverse effects than placebo.

  7. 21 CFR 312.42 - Clinical holds and requests for modification.

    Science.gov (United States)

    2010-04-01

    ...., affecting reproductive organs) or developmental toxicity (i.e., affecting potential offspring). The phrase... death is high unless the course of the disease is interrupted.” The clinical hold would not apply...

  8. MR coronary angiography with breath-hold targeted volumes: preliminary clinical results

    NARCIS (Netherlands)

    R.J.M. van Geuns (Robert Jan); P.A. Wielopolski (Piotr); H.G. de Bruin (Hein); B.J.W.M. Rensing (Benno); M. Hulshoff (Maarten); P.M.A. van Ooijen (Peter); P.J. de Feyter (Pim); M. Oudkerk (Matthijs)

    2000-01-01

    textabstractPURPOSE: To assess the clinical value of a magnetic resonance (MR) coronary angiography strategy involving a small targeted volume to image one coronary segment in a single breath hold for the detection of greater than 50% stenosis. MATERIALS AND METHODS:

  9. MR coronary angiography with breath-hold targeted volumes : Preliminary clinical results

    NARCIS (Netherlands)

    van Geuns, R J; Wielopolski, P A; de Bruin, Hein G.; Rensing, B J; Hulshoff, Marc; van Ooijen, P M; de Feyter, P J; Oudkerk, M

    2000-01-01

    PURPOSE: To assess the clinical value of a magnetic resonance (MR) coronary angiography strategy involving a small targeted volume to image one coronary segment in a single breath hold for the detection of greater than 50% stenosis. MATERIALS AND METHODS: Thirty-eight patients referred for elective

  10. Treatment of Chronic Breath-Holding in an Adult with Severe Mental Retardation: A Clinical Case Study

    Science.gov (United States)

    Reed, Derek D.; Martens, Brian K.

    2008-01-01

    We describe a clinical case study surrounding the behavioral assessment and operant treatment of, an adult with severe mental retardation who engaged in chronic breath-holding. In this clinical case, previous neurological and medical testing had ruled out biological bases for the individual's breath-holding. A functional behavioral assessment…

  11. Comparison of Salmonella species recovered from Irish liquid milk production holdings with temporal clinical veterinary isolates.

    Science.gov (United States)

    Murphy, Brenda P; Buckley, James F; O'Connor, Elizabeth M; Gilroy, Deirdre; Fanning, Séamus

    2008-07-01

    The presence of microbiological hazards in foodstuffs including, Salmonella, form a major source of food-borne diseases in humans. In-line milk filters from 97 liquid milk production holdings in Cork, the largest dairy region in Ireland, were surveyed for the presence of Salmonella species at herd level over a 2-year period (September 2001-September 2003). Each dairy farm was visited 6 times at 4 monthly intervals (denoted by cycles A-F). Six of the 97 herds (6%) were positive. Ten isolates were detected based on culture methods. These included five (5%) Salmonella Typhimurium DT104, 4 (4%) Salmonella Dublin, and 1 (1%) Salmonella Agona from a total of 556 filters. During cycle C, in addition to the milk filters, a bulk tank milk (BTM) sample was procured from each dairy holding and analysed but no Salmonella were isolated. For comparison purposes a further 26 temporal veterinary clinical isolates (21 S. Typhimurium of varying phage type, and 5 S. Dublin) were procured from the Cork Veterinary Clinical Diagnostic Laboratory, Cork. The study collection showed resistance to one or more antimicrobial agents. During the study, Salmonella spp. were isolated from five of the herds prior to any clinical signs in the farm animals. Pulsed-field gel electrophoresis (PFGE) profiles indicated clonality among the isolates pre- and post-clinical illness. A phenotypic and genotypic database for Salmonella spp. has been developed and used for comparative purposes.

  12. Conduct, Oversight, and Ethical Considerations of Clinical Trials in Companion Animals with Cancer: Report of a Workshop on Best Practice Recommendations.

    Science.gov (United States)

    Page, R; Baneux, P; Vail, D; Duda, L; Olson, P; Anestidou, L; Dybdal, N; Golab, G; Shelton, W; Salgaller, M; Hardy, C

    2016-01-01

    Development of effective and safe treatments for companion animals with cancer requires the collaboration of numerous animal health professionals and the full engagement of animal owners. Establishing 'Best Practice Recommendations' for clinical trials in veterinary oncology represents an important step toward meeting the goal of rigorous clinical trial design and conduct that is required to establish valid evidence. Likewise, optimizing patient welfare and owner education and advocacy is crucial to meet the unique ethical obligations to both owners and animals enrolled in these clinical trials and to ensure trust in the team conducting the research. To date, 'Best Practice Recommendations' for clinical trial conduct have not been reported for veterinary oncology. This document summarizes the consensus of a workshop held in November, 2014 to identify relevant ethical principles and to ensure responsible conduct of clinical research in companion animals with cancer. It is intended as a working document that will be updated as advances in science and ethical considerations require. To the extent possible, existing guidelines for the conduct and oversight of clinical trials in humans have been adapted for veterinary trials to avoid duplicative effort and to facilitate integration of clinical trials such that translational research with benefits for both companion animals and humans are encouraged. Copyright © 2016 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

  13. [HOLDING OBJECTIVE STRUCTURED CLINICAL EXAMINATIONS FOR ANESTHESIOLOGY AND INTENSIVE CARE CLINICAL RESIDENCY IN STATE GRADUATES CERTIFICATION].

    Science.gov (United States)

    Schegolev, A V; Andreenko, A A; Ershov, E N; Lahin, R E; Makarenko, E P

    2016-01-01

    The modern system of medical education requires objective methods to assess clinical competence of medical specialists. Application of objective structured clinical examination (OSCE) during the final certification of graduates of clinical residency allows to evaluate the theoretical knowledge, manual skills. Enabling simulation scenarios in the program makes it possible to objectively evaluate the important non-technical skills of anesthesiologists, identify gaps in the system of training and modify it. The experience of the objective structured clinical examination as part of the state certification of graduates of clinical residency of the Department ofAnesthesiology and Intensive Care, Military MedicalAcademy after C M Kirov allows us to consider this technique in an objective way a comprehensive assessment of the competence of health professionals. Students confirmed its highly realistic, they have revealed the presence of emotional stress during the simulation sessions, the majority agreed that the simulation session increased the level of their readiness to address these situations in clinical practice. Staff of the department is planning to testing and introduction rating scales into a system of assessment, to improved exam program, increasing the number of clinical scenarios for simulation sessions.

  14. 5 CFR 330.711 - Oversight.

    Science.gov (United States)

    2010-01-01

    ... PLACEMENT (GENERAL) Interagency Career Transition Assistance Plan for Displaced Employees § 330.711 Oversight. OPM is responsible for oversight of the Interagency Career Transition Assistance Plan...

  15. SU-E-T-177: Clinical Experience with Spirometer Guided Breath Hold Lung SBRT

    Energy Technology Data Exchange (ETDEWEB)

    Liu, H; Manning, M; Sintay, B; Maurer, J; Hayes, L; Wiant, D [Cone Health Cancer Center, Greensboro, NC (United States)

    2015-06-15

    Purpose: Tumor motion in lung SBRT is typically managed by creating an internal target volume (ITV) based on 4D-CT information. Another option, which may reduce lung dose and imaging artifact, is to use a breath hold (BH) during simulation and delivery. Here we evaluate the reproducibility of tumor position at repeated BH using a newly released spirometry system. Methods: Three patients underwent multiple BH CT’s at simulation. All patients underwent a BH cone beam CT (CBCT) prior to each treatment. All image sets were registered to a patient’s first simulation CT based on local bony anatomy. The gross tumor volume (GTV), and the diaphragm or the apex of the lung were contoured on the first image set and expanded in 1 mm increments until the GTVs and diaphragms on all image sets were included inside an expanded structure. The GTV and diaphragm margins necessary to encompass the structures were recorded. Results: The first patient underwent 2 BH CT’s and fluoroscopy at simulation, the remaining patients underwent 3 BH CT’s at simulation. In all cases the GTV’s remained within 1 mm expansions and the diaphragms remained within 2 mm expansions on repeat scans. Each patient underwent 3 daily BH CBCT’s. In all cases the GTV’s remained within a 2 mm expansions, and the diaphragms (or lung apex in one case) remained within 2 mm expansions at daily BH imaging. Conclusions: These case studies demonstrate spirometry as an effective tool for limiting tumor motion (and imaging artifact) and facilitating reproducible tumor positioning over multiple set-ups and BH’s. This work was partially supported by Qfix.

  16. Gene therapy oversight: lessons for nanobiotechnology.

    Science.gov (United States)

    Wolf, Susan M; Gupta, Rishi; Kohlhepp, Peter

    2009-01-01

    Oversight of human gene transfer research ("gene therapy") presents an important model with potential application to oversight of nanobiology research on human participants. Gene therapy oversight adds centralized federal review at the National Institutes of Health's Office of Biotechnology Activities and its Recombinant DNA Advisory Committee to standard oversight of human subjects research at the researcher's institution (by the Institutional Review Board and, for some research, the Institutional Biosafety Committee) and at the federal level by the Office for Human Research Protections. The Food and Drug Administration's Center for Biologics Evaluation and Research oversees human gene transfer research in parallel, including approval of protocols and regulation of products. This article traces the evolution of this dual oversight system; describes how the system is already addressing nanobiotechnology in gene transfer: evaluates gene therapy oversight based on public opinion, the literature, and preliminary expert elicitation; and offers lessons of the gene therapy oversight experience for oversight of nanobiotechnology.

  17. 12 CFR 370.10 - Oversight.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Oversight. 370.10 Section 370.10 Banks and... LIQUIDITY GUARANTEE PROGRAM § 370.10 Oversight. (a) Participating entities are subject to the FDIC's oversight regarding compliance with the terms of the temporary liquidity guarantee program. (b)...

  18. Initial clinical results for breath-hold CT-based processing of respiratory-gated PET acquisitions

    Energy Technology Data Exchange (ETDEWEB)

    Fin, Loic; Daouk, Joel; Morvan, Julie; Esper, Isabelle El; Saidi, Lazhar; Meyer, Marc-Etienne [Amiens University Hospital, Nuclear Medicine Department, Amiens (France); Bailly, Pascal [Amiens University Hospital, Nuclear Medicine Department, Amiens (France); CHU d' Amiens, Service de Medecine Nucleaire, unite TEP, Hopital Sud, Amiens cedex (France)

    2008-11-15

    Respiratory motion causes uptake in positron emission tomography (PET) images of chest structures to spread out and misregister with the CT images. This misregistration can alter the attenuation correction and thus the quantisation of PET images. In this paper, we present the first clinical results for a respiratory-gated PET (RG-PET) processing method based on a single breath-hold CT (BH-CT) acquisition, which seeks to improve diagnostic accuracy via better PET-to-CT co-registration. We refer to this method as ''CT-based'' RG-PET processing. Thirteen lesions were studied. Patients underwent a standard clinical PET protocol and then the CT-based protocol, which consists of a 10-min List Mode RG-PET acquisition, followed by a shallow end-expiration BH-CT. The respective performances of the CT-based and clinical PET methods were evaluated by comparing the distances between the lesions' centroids on PET and CT images. SUV{sub MAX} and volume variations were also investigated. The CT-based method showed significantly lower (p=0.027) centroid distances (mean change relative to the clinical method =-49%; range =-100% to 0%). This led to higher SUV{sub MAX} (mean change =+33%; range =-4% to 69%). Lesion volumes were significantly lower (p=0.022) in CT-based PET volumes (mean change =-39%: range =-74% to -1%) compared with clinical ones. A CT-based RG-PET processing method can be implemented in clinical practice with a small increase in radiation exposure. It improves PET-CT co-registration of lung lesions and should lead to more accurate attenuation correction and thus SUV measurement. (orig.)

  19. Anti-choice group seeks Supreme Court review of federal clinic access law; Congress holds hearings.

    Science.gov (United States)

    1995-05-19

    The Freedom of Access to Clinic Entrances Act (FACE) is a federal statute which was signed into law May 1994 prohibiting the use of force, threat of force, or physical obstruction to intentionally injure, intimidate, or interfere with anyone providing reproductive health services. Since FACE was enacted, seven federal district courts and one federal appellate court have found the measure constitutional, although one federal district court in Wisconsin did rule against FACE. Anti-choice activists have argued that neither the Commerce Clause nor the Fourteenth Amendment to the US Constitution empower Congress to enact FACE. Congress relied upon both constitutional provisions when it enacted the statute, recognizing that illegal, violent acts against abortion providers and their patients threaten to disrupt medical care nationwide and eliminate the right to choose abortion. The US Court of Appeals for the Fourth Circuit on February 13, 1995, however, unanimously upheld a lower court's dismissal of the case, finding that FACE does not violate the US Constitution. Relying upon an April 26 Supreme Court decision in United States vs. Lopez, which held that Congress did not have the power under the Commerce Clause to enact a federal statute prohibiting the possession of a firearm within 100 feet of a school zone, an anti-choice group and several individuals petitioned the US Supreme Court in a May 12 filing to review the appellate court ruling in American Life League vs. Reno. The petitioners also challenge the broad powers of Congress under the Fourteenth Amendment to remedy infringements upon constitutional rights and assert FACE violates the First Amendment and the Religious Freedom Restoration Act.

  20. Fiscal Year 2017 Oversight Plan

    Science.gov (United States)

    2016-12-01

    managing the development of a Mine Countermeasures Mission Package that will allow the Littoral Combat Ship to detect and neutralize mines or avoid...year. Of those investigations, an average Army Reserve and active duty agents participate in a joint training exercise focusing on crime scene ...a mock crime scene . Photo by Air Force Senior Airman Nesha Humes Office of Inspector General FY 2017 Oversight Plan Ensuring Ethical Conduct │ 99

  1. SU-F-P-30: Clinical Assessment of Auto Beam-Hold Triggered by Fiducial Localization During Prostate RapidArc Delivery

    Energy Technology Data Exchange (ETDEWEB)

    Atkinson, P; Chen, Q [Flower Hospital, Sylvania, OH (United States)

    2016-06-15

    Purpose: To assess the clinical efficacy of auto beam hold during prostate RapidArc delivery, triggered by fiducial localization on kV imaging with a Varian True Beam. Methods: Prostate patients with four gold fiducials were candidates in this study. Daily setup was accomplished by aligning to fiducials using orthogonal kV imaging. During RapidArc delivery, a kV image was automatically acquired with a momentary beam hold every 60 degrees of gantry rotation. The position of each fiducial was identified by a search algorithm and compared to a predetermined 1.4 cm diameter target area. Treatment continued if all the fiducials were within the target area. If any fiducial was outside the target area the beam hold was not released, and the operators determined if the patient needed re-alignment using the daily setup method. Results: Four patients were initially selected. For three patients, the auto beam hold performed seamlessly. In one instance, the system correctly identified misaligned fiducials, stopped treatment, and the patient was re-positioned. The fourth patient had a prosthetic hip which sometimes blocked the fiducials and caused the fiducial search algorithm to fail. The auto beam hold was disabled for this patient and the therapists manually monitored the fiducial positions during treatment. Average delivery time for a 2-arc fraction was increased by 59 seconds. Phantom studies indicated the dose discrepancy related to multiple beam holds is <0.1%. For a plan with 43 fractions, the additional imaging increased dose by an estimated 68 cGy. Conclusion: Automated intrafraction kV imaging can effectively perform auto beam holds due to patient movement, with the exception of prosthetic hip patients. The additional imaging dose and delivery time are clinically acceptable. It may be a cost-effective alternative to Calypso in RapidArc prostate patient delivery. Further study is warranted to explore its feasibility under various clinical conditions.

  2. Developing U.S. oversight strategies for nanobiotechnology: learning from past oversight experiences.

    Science.gov (United States)

    Paradise, Jordan; Wolf, Susan M; Kuzma, Jennifer; Kuzhabekova, Aliya; Tisdale, Alison W; Kokkoli, Efrosini; Ramachandran, Gurumurthy

    2009-01-01

    The emergence of nanotechnology, and specifically nanobiotechnology, raises major oversight challenges. In the United States, government, industry, and researchers are debating what oversight approaches are most appropriate. Among the federal agencies already embroiled in discussion of oversight approaches are the Food and Drug Administration (FDA), Environmental Protection Agency (EPA), Department of Agriculture (USDA), Occupational Safety and Health Administration (OSHA), and National Institutes of Health (NIH). All can learn from assessment of the successes and failures of past oversight efforts aimed at emerging technologies. This article reports on work funded by the National Science Foundation (NSF) aimed at learning the lessons of past oversight efforts. The article offers insights that emerge from comparing five oversight case studies that examine oversight of genetically engineered organisms (GEOs) in the food supply, pharmaceuticals, medical devices, chemicals in the workplace, and gene therapy. Using quantitative and qualitative analysis, the authors present a new way of evaluating oversight.

  3. Hypofractionated image-guided breath-hold SABR (Stereotactic Ablative Body Radiotherapy of liver metastases – clinical results

    Directory of Open Access Journals (Sweden)

    Boda-Heggemann Judit

    2012-06-01

    Full Text Available Abstract Purpose Stereotactic Ablative Body Radiotherapy (SABR is a non-invasive therapy option for inoperable liver oligometastases. Outcome and toxicity were retrospectively evaluated in a single-institution patient cohort who had undergone ultrasound-guided breath-hold SABR. Patients and methods 19 patients with liver metastases of various primary tumors consecutively treated with SABR (image-guidance with stereotactic ultrasound in combination with computer-controlled breath-hold were analysed regarding overall-survival (OS, progression-free-survival (PFS, progression pattern, local control (LC, acute and late toxicity. Results PTV (planning target volume-size was 108 ± 109cm3 (median 67.4 cm3. BED2 (Biologically effective dose in 2 Gy fraction was 83.3 ± 26.2 Gy (median 78 Gy. Median follow-up and median OS were 12 months. Actuarial 2-year-OS-rate was 31%. Median PFS was 4 months, actuarial 1-year-PFS-rate was 20%. Site of first progression was predominantly distant. Regression of irradiated lesions was observed in 84% (median time to detection of regression was 2 months. Actuarial 6-month-LC-rate was 92%, 1- and 2-years-LC-rate 57%, respectively. BED2 influenced LC. When a cut-off of BED2 = 78 Gy was used, the higher BED2 values resulted in improved local control with a statistical trend to significance (p = 0.0999. Larger PTV-sizes, inversely correlated with applied dose, resulted in lower local control, also with a trend to significance (p-value = 0.08 when a volume cut-off of 67 cm3 was used. No local relapse was observed at PTV-sizes 3 and BED2 > 78 Gy. No acute clinical toxicity > °2 was observed. Late toxicity was also ≤ °2 with the exception of one gastrointestinal bleeding-episode 1 year post-SABR. A statistically significant elevation in the acute phase was observed for alkaline-phosphatase; in the chronic phase for alkaline-phosphatase, bilirubine, cholinesterase and C

  4. 14 CFR 1203b.108 - Management oversight.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Management oversight. 1203b.108 Section 1203b.108 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SECURITY PROGRAMS; ARREST AUTHORITY AND USE OF FORCE BY NASA SECURITY FORCE PERSONNEL § 1203b.108 Management oversight. (a)...

  5. Research Ethics, Governance, Oversight And Public Interest

    Directory of Open Access Journals (Sweden)

    Abu Bakar Suleiman

    2008-12-01

    Full Text Available A better educated public has started to challengethe way decisions are made in medical research activities.Although Institutional and National Guidelines onResearch are in place, there are fears that InstitutionalReview Boards (IRBs and funding agencies are only fairlyactive in scientific and ethical reviews of research proposalsbut not on oversight of projects after their initiation. Theseissues are integral to good research governance andresearchers and custodians of research ethics must ensurethat public interest is not compromised. Medical progress is based on research including humanexperimentation carried out according to guidingprinciples as enunciated in the Declaration of Helsinki(2000, but the quality of compliance with theDeclaration is an important issue. Better choice and appropriate training of members of IRBsto improve the quality of decision making and governanceprocesses are urgently needed. Competency in evaluationof proposals requires not only the appropriate scientificknowledge but also access to relevant preclinical andother data. Unfortunately, the completeness and quality ofsuch data may not be adequate. Public interest demands that injury to trial subjects inclinical trials is minimized if not avoided completely.Unfortunately this is not always possible with trialswhere novel biological modes of action are tested.A more robust evaluation mechanism for projectapproval may minimize but not completely avoid injuryto subjects; thus insurance cover to provide care andcompensation to subjects must be compulsory.The decision to approve or reject a project must bebased on the balance of potential risks and benefits,taking into consideration justifiable distributive risks totarget communities and populations. Economicconsiderations should never be the primary focus,especially when there are real concerns that themigration of early phase clinical trials including vaccinetrials to developing countries is based on the perceivedless

  6. Overview of the Regulatory Oversight Implemented by the French Regulatory Authorities for the Clinical Investigation of Gene Therapy and Cell Therapy Products.

    Science.gov (United States)

    Lucas-Samuel, Sophie; Ferry, Nicolas; Trouvin, Jean-Hugues

    2015-01-01

    Advanced therapy medicinal products, a new class of products with promising therapeutic effects, have been classified as medicinal products and as such should be developed according to a well-structured development plan, to establish their quality, safety and efficacy profile and conclude, at the time of the marketing authorisation evaluation, on a positive risk/benefit balance for patients. An important part of this development plan is achieved through clinical trials, which have also to be approved according to a well-established regulatory process, prior any initiation. This chapter is dedicated to describe the regulatory pathway to be followed in France, before initiating any clinical trial with those investigational advanced therapy medicinal products. In France, to get the final authorisation to initiate a clinical trial, the legislation imposes to run in parallel two independent but complementary authorisation procedures. The first procedure is aimed at assessing the ethical aspect of the biomedical research, while the second has to review the safety and regulatory aspects. A third procedure has to be envisaged where in case the investigational product consists or contains a genetically modified organism. The French system herein described is in line with the EU regulation on clinical trial and follows the respective deadlines for granting the final approval. The complexity of the procedure is in fact more due to the complexity of the products and protocols to be assessed than to the procedure itself which is now very close to the well-known procedure applied routinely for more conventional chemical or biological candidate medicinal products.

  7. Ethics Oversight Mechanisms for Surgical Innovation: A Systematic and Comparative Review of Arguments.

    Science.gov (United States)

    Karpowicz, Lila; Bell, Emily; Racine, Eric

    2016-04-01

    Surgical innovation typically falls under the purview of neither conventional clinical ethics nor research ethics. Due to a lack of oversight for surgical innovation-combined with a potential for significant risk-a wide range of arguments has been advanced in the literature to support or undermine various oversight mechanisms. To scrutinize the argumentation surrounding oversight options, we conducted a systematic review of published arguments. We found that the arguments are typically grounded in common sense and speculation instead of evidence. Presently, the justification or superiority for any single oversight mechanism for surgical innovation cannot be established convincingly. We suggest ways to improve the argument-based literature and discuss the value of systematic reviews of arguments and reasons. © The Author(s) 2016.

  8. 13 CFR 120.1005 - Bureau of PCLP Oversight.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Bureau of PCLP Oversight. 120.1005 Section 120.1005 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Risk-Based Lender Oversight Supervision § 120.1005 Bureau of PCLP Oversight. SBA's Bureau of PCLP Oversight...

  9. Oversight Institutions Within the United Nations

    DEFF Research Database (Denmark)

    Pontoppidan, Caroline Aggestam

    2015-01-01

    This article will give a description of the role of internal audit and governance functions within the United Nations system. The United Nations has, during the last 10 years, worked to establish effective oversight services. Oversight, governance and hereunder the internal audit function has been...... a key priority within the United Nations and a crucial ingredient in the Secretary-General’s efforts to reform and strengthen the United Nations to meet the challenges of the 21st century....

  10. Oversight Institutions Within the United Nations

    DEFF Research Database (Denmark)

    Pontoppidan, Caroline Aggestam

    2015-01-01

    This article will give a description of the role of internal audit and governance functions within the United Nations system. The United Nations has, during the last 10 years, worked to establish effective oversight services. Oversight, governance and hereunder the internal audit function has been...... a key priority within the United Nations and a crucial ingredient in the Secretary-General’s efforts to reform and strengthen the United Nations to meet the challenges of the 21st century....

  11. The holding environment and intersubjectivity.

    Science.gov (United States)

    Ginot, E

    2001-04-01

    The holding environment is explored in the context of the analytic dyad, where it is seen as rooted in the patient's need to be experientially known through the intersubjective interaction. In examining previous emphasis on holding as an optimally attuned empathic environment provided by the analyst, a broadened view of what constitutes a holding environment is presented, underscoring its interactional nature. A distinction is made between empathic holding based on the patient's expressed material, and holding that is generated through the analyst's intersubjective knowledge, gained via ongoing intersubjective engagements and enactments. It is argued that the unmediated connection to the patient's internal representations resulting from these intersubjective interactions, and the ensuing verbal exploration of them, can create a profound sense of being understood and thus held. A clinical process depicting the experience of holding in an intersubjective context is presented.

  12. F-35 Joint Strike Fighter: Development of New Capabilities Requires Continued Oversight

    Science.gov (United States)

    2016-04-26

    number of changes affecting the planned quantities and associated costs . According to current projections, the U.S. portion of the program will require...Strike Fighter F-35 Joint Strike Fighter Block 4 Development Costs Increase Near-Term Funding Needs DOD does not currently plan to manage...difficult for Congress to hold it accountable for achieving its cost , schedule, and performance requirements. Given that congressional oversight

  13. "Step" versus "phase" in the clinical development of biosimilars: the correct noun holds the key to success

    OpenAIRE

    Ewesuedo R

    2016-01-01

    Reginald Ewesuedo Pfizer Inc., Cambridge, MA, USA Abstract: The availability of biosimilars (also known as follow-on biologic or subsequent entry biologic, etc) is expected to improve access to health care and to provide more affordable alternatives to the reference products. However, despite this promise, based on publicly available information from clinical trial databases, there is apparent global disparity in participation (more so in oncology) and interest in the clinical development of ...

  14. SU-E-T-361: Clinical Benefit of Automatic Beam Gating Mixed with Breath Hold in Radiation Therapy of Left Breast

    Energy Technology Data Exchange (ETDEWEB)

    Wu, J; Hill, G; Spiegel, J [Swedish Cancer Institute, Issaquah, Washington (United States); Ye, J [Swedish Cancer Institute, Edmond, Washington (United States); Mehta, V [Swedish Cancer Institute, Seattle, WA (United States)

    2014-06-01

    Purpose: To investigate the clinical and dosimetric benefits of automatic gating of left breast mixed with breath-hold technique. Methods: Two Active Breathing Control systems, ABC2.0 and ABC3.0, were used during simulation and treatment delivery. The two systems are different such that ABC2.0 is a breath-hold system without beam control capability, while ABC3.0 has capability in both breath-hold and beam gating. At simulation, each patient was scanned twice: one with free breathing (FB) and one with breath hold through ABC. Treatment plan was generated on the CT with ABC. The same plan was also recalculated on the CT with FB. These two plans were compared to assess plan quality. For treatments with ABC2.0, beams with MU > 55 were manually split into multiple subfields. All subfields were identical and shared the total MU. For treatment with ABC3.0, beam splitting was unnecessary. Instead, treatment was delivered in gating mode mixed with breath-hold technique. Treatment delivery efficiency using the two systems was compared. Results: The prescribed dose was 50.4Gy at 1.8Gy/fraction. The maximum heart dose averaged over 10 patients was 46.0±2.5Gy and 24.5±12.2Gy for treatments with FB and with ABC respectively. The corresponding heart V10 was 13.2±3.6% and 1.0±1.6% respectively. The averaged MUs were 99.8±7.5 for LMT, 99.2±9.4 for LLT. For treatment with ABC2.0, normally the original beam was split into 2 subfields. The averaged total time to delivery all beams was 4.3±0.4min for treatments with ABC2.0 and 3.3±0.6min for treatments with ABC3.0 in gating mode. Conclusion: Treatment with ABC tremendously reduced heart dose. Compared to treatments with ABC2.0, gating with ABC3.0 reduced the total treatment time by 23%. Use of ABC3.0 improved the delivery efficiency, and eliminated the possibility of mistreatments. The latter may happen with ABC2.0 where beam is not terminated when breath signal falls outside of the treatment window.

  15. "Step" versus "phase" in the clinical development of biosimilars: the correct noun holds the key to success

    Directory of Open Access Journals (Sweden)

    Ewesuedo R

    2016-06-01

    Full Text Available Reginald Ewesuedo Pfizer Inc., Cambridge, MA, USA Abstract: The availability of biosimilars (also known as follow-on biologic or subsequent entry biologic, etc is expected to improve access to health care and to provide more affordable alternatives to the reference products. However, despite this promise, based on publicly available information from clinical trial databases, there is apparent global disparity in participation (more so in oncology and interest in the clinical development of proposed biosimilars. The disparity seems to be partly due to lack of access to biologics, as well as expectations of the development process and/or study objectives. There is inherent misalignment between the characterizations of the clinical studies, in the public domain, with regulatory guidance (eg, the use of “Phase” to describe a comparative study. There is also apparent non-appreciation of potential research opportunities afforded by the biosimilar development paradigm. It is imperative that key stakeholders required for the development of this class of drugs are adequately engaged and that they fully understand the development paradigm, if the promises of biosimilars are to be realized globally. Keywords: p-biosims, follow-on biologic, biologics, regulatory guidelines, clinical studies

  16. Management of Holding and Evaluating Comprehensive System of Electronic Clinical Reasoning Exams (Sajab in the Sixth Nationwide Medical Sciences Students Olympiad

    Directory of Open Access Journals (Sweden)

    Manouchehr Khoshbaten

    2015-12-01

    Full Text Available Introduction: The Nationwide Medical Sciences Students purpose of the Olympiad is to discover student’s talents and encourage them to study. It seems that holding regional Olympiad exams to select students for the National Olympiad can help us to maintain fairness. The aim of this study is Management of Holding and Evaluating Clinical Reasoning Exams Using a Comprehensive System of Electronic Clinical Reasoning Exams. Methods: Study was carried out in 2013 at the University of Medical Sciences on 750 students, 250 question designers, 37 responsibles. The nationwide universities held regional exams for the Student Olympiad in the area of clinical reasoning on specific dates and times. A quality review of the exams was done to study the strengths and weaknesses and to eliminate shortcomings and problems. Therefore, a researcher created a questionnaire with a reliability of R= 0.86 and validity was confirmed by experts, which was then loaded into the system. The collected data were analyzed using SPSS and descriptive statistics (Percent, Average, standard deviation. Results: The multimedia educational quality of the system, with an average of 69.36 ±22.79, the students and faculty members evaluated as good, with averages of 64.30 ±23.48 and 67.28 ± 22.43, respectively. The quality of the exam was evaluated as excellent by faculty members, with an average of 94.63 ±16.60 and 59.52 ±27.46, by the students. Conclusion: Evaluating the quality of the system’s performance and its ability to assess students will lead to a clarification of its strengths and weaknesses. Finally, result in the creation of a high quality evaluation system.

  17. 12 CFR 985.4 - Finance Board oversight.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Finance Board oversight. 985.4 Section 985.4 Banks and Banking FEDERAL HOUSING FINANCE BOARD OFFICE OF FINANCE THE OFFICE OF FINANCE § 985.4 Finance Board oversight. (a) Oversight and enforcement actions. The Finance Board shall have the same...

  18. 13 CFR 120.1000 - Risk-Based Lender Oversight.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Risk-Based Lender Oversight. 120.1000 Section 120.1000 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Risk-Based Lender Oversight Supervision § 120.1000 Risk-Based Lender Oversight. (a) Risk-Based...

  19. 13 CFR 120.1070 - Lender oversight fees.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Lender oversight fees. 120.1070 Section 120.1070 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Risk-Based Lender Oversight Supervision § 120.1070 Lender oversight fees. Lenders are required to pay to SBA fees...

  20. Workshop Report: Joint Requirements. Oversight Council Process.

    Science.gov (United States)

    2007-11-02

    Brinkley ...................................... 73 10. Integration, Dr. W illiam G. Lese, Jr ....................................... 81 Part III...author. several MORS prizes that recognize outstanding Quoted in: Alan L. Mackay, The Harvest of a Quiet Eye analysis efforts. (1977). 22 Joint...Oversight Council Process 72 9. Joint Readiness William A. Brinkley Introduction 9 individual JWCA assessments and The Military Operations Research

  1. Toward Better Oversight of NGS Tests.

    Science.gov (United States)

    2016-09-01

    The FDA has published two draft guidance documents aimed at streamlining its oversight of tests based on next-generation sequencing (NGS). One contains preliminary recommendations addressing the analytic validity of NGS-based tests for hereditary diseases; the other explains how test developers can obtain official recognition of their genetic variant databases, potentially speeding marketing clearance or approval.

  2. Oversight of the Liberian National Police

    Science.gov (United States)

    2009-01-01

    Capetown , 2005. 3 Open Society Foundation for South Africa, Strengthening Police Oversight in South Africa, 2005. African Experience 7 The national...Berg, Police Accountability in Southern Africa Commonwealth Countries, Cape Town, South Africa: Institute of Crimi- nology, University of Capetown ...Institute of Criminology, University of Capetown , 2005. ———, Police Accountability in Southern Africa Commonwealth Countries, Cape Town, South Africa

  3. Deep Inspiration Breath Hold [(18)F]FDG PET-CT on 4-rings scanners in evaluating lung lesions: evidences from a phantom and a clinical study.

    Science.gov (United States)

    Caobelli, Federico; Puta, Erinda; Kaiser, Stefano Ren; Massetti, Valentina; Andreoli, Michela; Mostarda, Angelica; Soffientini, Alberto; Pizzocaro, Claudio; Guerra, Ugo Paolo

    2014-01-01

    To investigate the clinical feasibility of a Deep Inspiration Breath Hold (DIBH) (18)F-FDG PET-CT acquisition in apnea and compare the results obtained between these acts of acquisition in apnea and in Free Breathing in the evaluation of lung lesions. A pre-clinical phantom study was performed to evaluate the shortest simulated DIBH time according to the minimum detectable lesion that can be detected by our ultrasound scanner. This study was conducted by changing acquisition time and sphere-to-background activity ratio values and by using radioactivity densities similar to those generally found in clinical examinations. In the clinical study, 25 patients with pulmonary lesions underwent a standard whole body (18)F-FDG PET-CT scan in free breathing followed by a 20s single thorax acquisition PET/CT in DIBH acquisition. The phantom study indicated that a 20-s acquisition time provides an accurate evaluation of smallest sphere shaped lesions. In the clinical study, PET-CT scans obtained in DIBH studies showed a significant reduction of misalignment between the PET and CT scan images and an increase of SUVmax compared to free breathing acquisitions. A correlation between the %BH-index and lesion displacement between PET and CT images in FB acquisition was demonstrated, significantly higher for lesions with a displacement>8mm. The single 20s acquisition of DIBH PET-CT is a feasible technique for lung lesion detection in the clinical setting. It only requires a minor increase in examination time without special patient training. 20s DIBH scan provided a more precise measurement of SUVmax, especially for lesions in the lower lung lobes which usually show greater displacement between PET and CT scan images in FB acquisition. Copyright © 2013 Elsevier España, S.L. and SEMNIM. All rights reserved.

  4. Corporate social responsibility for nanotechnology oversight.

    Science.gov (United States)

    Kuzma, Jennifer; Kuzhabekova, Aliya

    2011-11-01

    Growing public concern and uncertainties surrounding emerging technologies suggest the need for socially-responsible behavior of companies in the development and implementation of oversight systems for them. In this paper, we argue that corporate social responsibility (CSR) is an important aspect of nanotechnology oversight given the role of trust in shaping public attitudes about nanotechnology and the lack of data about the health and environmental risks of nanoproducts. We argue that CSR is strengthened by the adoption of stakeholder-driven models and attention to moral principles in policies and programs. In this context, we examine drivers of CSR, contextual and leadership factors that influence CSR, and strategies for CSR. To illustrate these concepts, we discuss existing cases of CSR-like behavior in nanotechnology companies, and then provide examples of how companies producing nanomedicines can exhibit morally-driven CSR behavior.

  5. SU-F-BRB-02: Towards Quantitative Clinical Decision On Deep Inspiration Breath Hold (DIBH) Or Prone for Left-Sided Breast Irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Lin, H; Gao, Y [Rensselaer Polytechnic Institute, Troy, NY (United States); Liu, T [Memorial Sloan Kettering West Harrison, West Harrison, New York (United States); Gelblum, D; Ho, A [Memorial Sloan Lettering Cancer Center, New York City, New York (United States); Powell, S [Memorial Sloan Kettering Cancer Center, New York, NY (United States); Tang, X [Memorial Sloan Kettering Cancer Center, West Harrison, NY (United States); Xu, X [Rensselaer Polytechnic Inst., Troy, NY (United States)

    2015-06-15

    Purpose: To develop quantitative clinical guidelines between supine Deep Inspiratory Breath Hold (DIBH) and prone free breathing treatments for breast patients, we applied 3D deformable phantoms to perform Monte Carlo simulation to predict corresponding Dose to the Organs at Risk (OARs). Methods: The RPI-adult female phantom (two selected cup sizes: A and D) was used to represent the female patient, and it was simulated using the MCNP6 Monte Carlo code. Doses to OARs were investigated for supine DIBH and prone treatments, considering two breast sizes. The fluence maps of the 6-MV opposed tangential fields were exported. In the Monte Carlo simulation, the fluence maps allow each simulated photon particle to be weighed in the final dose calculation. The relative error of all dose calculations was kept below 5% by simulating 3*10{sup 7} photons for each projection. Results: In terms of dosimetric accuracy, the RPI Adult Female phantom with cup size D in DIBH positioning matched with a DIBH treatment plan of the patient. Based on the simulation results, for cup size D phantom, prone positioning reduced the cardiac dose and the dose to other OARs, while cup size A phantom benefits more from DIBH positioning. Comparing simulation results for cup size A and D phantom, dose to OARs was generally higher for the large breast size due to increased scattering arising from a larger portion of the body in the primary beam. The lower dose that was registered for the heart in the large breast phantom in prone positioning was due to the increase of the distance between the heart and the primary beam when the breast was pendulous. Conclusion: Our 3D deformable phantom appears an excellent tool to predict dose to the OARs for the supine DIBH and prone positions, which might help quantitative clinical decisions. Further investigation will be conducted. National Institutes of Health R01EB015478.

  6. Single breath-hold magnetic resonance cine imaging for fast assessment of global and regional left ventricular function in clinical routine

    Energy Technology Data Exchange (ETDEWEB)

    Nassenstein, Kai; Heilmaier, Christina; Schlosser, Thomas [University Hospital Essen, Department of Diagnostic and Interventional Radiology and Neuroradiology, Essen (Germany); Eberle, Holger; Jensen, Christoph J.; Bruder, Oliver [Elisabeth Hospital Essen, Department of Cardiology and Angiology, Essen (Germany); Maderwald, Stefan [University Hospital Essen, Department of Diagnostic and Interventional Radiology and Neuroradiology, Essen (Germany); University Duisburg-Essen, Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen (Germany)

    2010-10-15

    To evaluate a TGRAPPA (temporal parallel acquisition technique)-accelerated, single breath-hold multi-slice cine imaging approach for the assessment of left ventricular (LV) function. One hundred eleven patients were examined at 1.5 T. Cine imaging was performed with single-slice breath-hold acquisitions in short-axis orientation using a SSFP (TR 2.63 ms, TE 1.12 ms, FA 72 ) sequence and a TGRAPPA SSFP (TR 2.66 ms, TE 1.11 ms, FA 72 , AF 3) sequence, which covered the entire LV in multiple short-axis slices during a single breath-hold. End-diastolic (EDV), end-systolic (ESV), stroke volumes (SV), ejection fraction (EF), muscle mass (MM) and regional wall motion were assessed for both data sets. Single breath-hold imaging was feasible in 108 patients. Excellent correlations were observed for all volumetric parameters derived from both data sets (all r > 0.97). While EDV and ESV showed marginally lower values for single breath-hold imaging (EDV: -1.6 {+-} 7.9 ml; ESV: -1.8 {+-} 6.0 ml, p < 0.05), no differences were observed for SV, EF, MM and regional wall motion assessment. Single breath-hold imaging required significant shorter acquisition times (28 {+-} 6 s vs. 335 {+-} 87 s). TGRAPPA-accelerated multi-slice SSPF imaging allows for fast and accurate assessment of regional and global LV function within a single breath-hold. (orig.)

  7. The Spider Web of Oversight: An Analysis of External Oversight of Higher Education

    Science.gov (United States)

    Lane, Jason E.

    2007-01-01

    Over the past several decades, state officials and various interest groups and civic organizations have increased their level of direct involvement in the affairs of public higher education. The increase in external attention toward the academy would likely be accompanied by the development of oversight mechanisms to ensure that societal…

  8. Small holding circles

    CERN Document Server

    Fruchard, Augustin

    2010-01-01

    A circle C holds a convex body K if C does not meet the interior of K and if there does not exist any euclidean displacement which moves C as far as desired from K, avoiding the interior of K. The purpose of this note is to explore how small can be a holding circle.

  9. 10 CFR 440.23 - Oversight, training, and technical assistance.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Oversight, training, and technical assistance. 440.23... PERSONS § 440.23 Oversight, training, and technical assistance. (a) The Secretary and the appropriate..., directly or indirectly, training and technical assistance to any grantee or subgrantee. Such training and...

  10. 32 CFR 2700.51 - Information Security Oversight Committee.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Information Security Oversight Committee. 2700.51 Section 2700.51 National Defense Other Regulations Relating to National Defense OFFICE FOR MICRONESIAN STATUS NEGOTIATIONS SECURITY INFORMATION REGULATIONS Implementation and Review § 2700.51 Information Security Oversight Committee. The...

  11. 41 CFR 105-53.133 - Information Security Oversight Office.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Information Security... FUNCTIONS Central Offices § 105-53.133 Information Security Oversight Office. (a) Creation and authority. The Information Security Oversight Office (ISOO), headed by the Director of ISOO, who is appointed...

  12. 76 FR 71081 - Public Aircraft Oversight Safety Forum

    Science.gov (United States)

    2011-11-16

    ... SAFETY BOARD Public Aircraft Oversight Safety Forum The National Transportation Safety Board (NTSB) will convene a Public Aircraft Oversight Safety Forum which will begin at 9 a.m., Wednesday, November 30, 2011. NTSB Chairman Deborah A.P. Hersman will chair the two-day forum and all five Board Members will...

  13. A managed care cycle provides contract oversight.

    Science.gov (United States)

    Stevenson, Paul B; Messinger, Stephen F; Welter, Terri

    2002-03-01

    In response to poor payment performance by health plans, providers are realizing that managed care contracts require systematic, ongoing management rather than a periodic focus. An effective managed care cycle that encompasses strategy development, implementation of the strategy through contracting and operations, and monitoring of contract performance can accomplish this needed oversight. Each phase requires specialized management tools, skills, and staff. Because of the importance of managed care to the provider's financial viability, a wide range of persons should be involved in the managed care cycle, including the board of directors, business office staff, senior management, and finance staff. As providers embrace a more structured approach to managed care, they will increase their chances of receiving accurate contracted payments.

  14. Review of the OSHA framework for oversight of occupational environments.

    Science.gov (United States)

    Choi, Jae-Young; Ramachandran, Gurumurthy

    2009-01-01

    The OSHA system for oversight of chemicals in the workplace was evaluated to derive lessons for oversight of nanotechnology. Criteria relating to the development, attributes, evolution, and outcomes of the system were used for evaluation that was based upon quantitative expert elicitation and historical literature analysis. The oversight system had inadequate resources in terms of finances, expertise, and personnel, and insufficient incentive for compliance. The system showed a lack of flexibility in novel situations. There were minimal requirements on companies for data on health and safety of their products. These factors have a strong influence on public confidence and health and safety. The oversight system also scored low on attributes such as public input, transparency, empirical basis, conflict of interest, and informed consent. The experts in our sample tend to believe that the current oversight system for chemicals in the workplace is neither adequate nor effective. It is very likely that the performance of the OSHA oversight system for nanomaterials will be equally inadequate.

  15. Nonverbal contention and contempt in U.K. parliamentary oversight hearings on fiscal and monetary policy.

    Science.gov (United States)

    Schonhardt-Bailey, Cheryl

    2017-01-01

    In parliamentary committee oversight hearings on fiscal policy, monetary policy, and financial stability, where verbal deliberation is the focus, nonverbal communication may be crucial in the acceptance or rejection of arguments proffered by policymakers. Systematic qualitative coding of these hearings in the 2010-15 U.K. Parliament finds the following: (1) facial expressions, particularly in the form of anger and contempt, are more prevalent in fiscal policy hearings, where backbench parliamentarians hold frontbench parliamentarians to account, than in monetary policy or financial stability hearings, where the witnesses being held to account are unelected policy experts; (2) comparing committees across chambers, hearings in the House of Lords committee yield more reassuring facial expressions relative to hearings in the House of Commons committee, suggesting a more relaxed and less adversarial context in the former; and (3) central bank witnesses appearing before both the Lords and Commons committees tend toward expressions of appeasement, suggesting a willingness to defer to Parliament.

  16. Preventive medicine oversight of splash pads on military installations.

    Science.gov (United States)

    Hardcastle, Lisa Raysby; Perry, Matthew; Browne, Ashley

    2015-01-01

    Over the past several years, an increasing number of military installations have installed splash pads that provide fun, recreational water entertainment for Soldiers and their families. The addition of splash pads brings added responsibilities for medical treatment facility preventive medicine oversight and installation facilities maintenance to ensure a safe and healthy environment. Currently, there are no consistent standards or detailed guidance for military installations to follow when installing and maintaining splash pads. The central issues associated with splash pads on military installations are water quality and risk for waterborne illnesses, responsibility for safety and health oversight, and federal energy and water sustainability mandates. This article examines the importance of implementing a standard for design and oversight to ensure the health and safety of Soldiers and their families.

  17. Defense Acquisitions: Future Aerostat and Airship Investment Decisions Drive Oversight and Coordination Needs

    Science.gov (United States)

    2012-10-01

    DEFENSE ACQUISITIONS Future Aerostat and Airship Investment Decisions Drive Oversight and Coordination Needs...Future Aerostat and Airship Investment Decisions Drive Oversight and Coordination Needs 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT...Future Aerostat and Airship Investment Decisions Drive Oversight and Coordination Needs Why GAO Did This Study Use of lighter-than-air platforms, such

  18. 20 CFR 667.410 - What are the oversight roles and responsibilities of recipients and subrecipients?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What are the oversight roles and... INVESTMENT ACT Oversight and Monitoring § 667.410 What are the oversight roles and responsibilities of recipients and subrecipients? (a) Roles and responsibilities for all recipients and subrecipients of funds...

  19. 75 FR 39954 - Oversight of Laboratory Developed Tests; Public Meeting; Change of Meeting Location

    Science.gov (United States)

    2010-07-13

    ... HUMAN SERVICES Food and Drug Administration Oversight of Laboratory Developed Tests; Public Meeting... entitled ``Oversight of Laboratory Developed Tests.'' A new address is given for those attending the public... interested stakeholders to discuss the agency's oversight of laboratory developed tests. FDA announced in...

  20. Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer. Dosimetrical comparison and clinical feasibility in 20 patients

    Energy Technology Data Exchange (ETDEWEB)

    Hepp, Rodrigo; Ammerpohl, Mark; Morgenstern, Christina; Erichsen, Patricia [Evangelische Kliniken Gelsenkirchen, Klinik fuer Strahlentherapie und Radioonkologie, Gelsenkirchen (Germany); Nielinger, Lisa [Evangelische Kliniken Gelsenkirchen, Klinik fuer Strahlentherapie und Radioonkologie, Gelsenkirchen (Germany); Hochschule Hamm-Lippstadt, Lippstadt (Germany); Abdallah, Abdallah [Evangelische Kliniken Gelsenkirchen, Klinik fuer Senologie, Gelsenkirchen (Germany); Galalae, Razvan [Evangelische Kliniken Gelsenkirchen, Klinik fuer Strahlentherapie und Radioonkologie, Gelsenkirchen (Germany); Christian-Albrechts-Universitaet zu Kiel, Medizinische Fakultaet, Kiel (Germany)

    2015-09-15

    Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients' acceptance/compliance and associated additional workload. Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 cm{sup 3} (D{sub 2} {sub cm} {sup 3}), volume receiving ≥ 5 Gy (V{sub 5}), 10 Gy (V{sub 10}), 15 Gy (V{sub 15}) and 20 Gy (V{sub 20}). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart D{sub 2} {sub cm} {sup 3} was less than 42 Gy in DIBH. In FB the heart D{sub 2} {sub cm} {sup 3} was ≥ 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. Radiotherapy of the left breast in DIBH using a SS could easily be incorporated into daily routine and is associated with significant dose reduction to the heart and IL. (orig.) [German] Die adjuvante Strahlentherapie nach brusterhaltener Operation (BCS) bei Brustkrebs (BC) ist eine seit langem anerkannte Behandlungsform. Das postradiogene Risiko einer kardialen Ischaemie steigt linear ohne erkennbaren Schwellenwert mit der mittleren Herzdosis. Die Bestrahlung der linken Brust in tiefer Inspiration unter Anhalten der

  1. Commentary: Emerging technologies oversight: research, regulation, and commercialization.

    Science.gov (United States)

    Johnson, Robbin

    2009-01-01

    This paper reviews the paper by Kuzma, Najmaie, and Larson that looks at what can be learned from the experience with genetically engineered organisms for oversight of emerging technologies more generally. That paper identifies key attributes of a good oversight system: promoting innovation, ensuring safety, identifying benefits, assessing costs, and doing so all while building public confidence. In commenting on that analysis, this paper suggests that looking at "oversight" in three phases - research and development, regulatory review, and market acceptance - can help to determine when certain of these attributes should take precedence over others and how to structure remedies when an error occurs. The result is an approach that is precautionary with respect to research and development, prudent and open to public input in the regulatory review stage, and purposefully persuasive once market acceptability is at stake, with remedies that are risk-containing in the first phase, risk-managing in the second, and risk-assuaging in the third. Combining the key attributes with the idea of three phases can help attune oversight to society's needs.

  2. 32 CFR 2103.51 - Information Security Oversight Committee.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Information Security Oversight Committee. 2103.51 Section 2103.51 National Defense Other Regulations Relating to National Defense NATIONAL SECURITY COUNCIL REGULATIONS TO IMPLEMENT E.O. 12065-INCLUDING PROCEDURES FOR PUBLIC ACCESS TO DOCUMENTS THAT MAY BE DECLASSIFIED Implementation and Review...

  3. 15 CFR 2008.18 - Information Security Oversight Committee.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Information Security Oversight Committee. 2008.18 Section 2008.18 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE REGULATIONS TO IMPLEMENT E.O. 12065; OFFICE OF THE UNITED STATES TRADE...

  4. 13 CFR 130.800 - Oversight of the SBDC program.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Oversight of the SBDC program. 130.800 Section 130.800 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS... funds for the benefit of the small business community....

  5. Oversight Report on Nontraditional Vocational Training for Female Inmates.

    Science.gov (United States)

    Florida State House of Representatives, Tallahassee.

    In January 1993, Florida's Correctional Education School Authority (CESA) studied the vocational interests of 125 randomly selected female inmates at the 3 female state correctional facilities in Florida. After two additional informal studies, an interim oversight review was conducted to determine the following: whether CESA was in compliance with…

  6. 42 CFR 460.71 - Oversight of direct participant care.

    Science.gov (United States)

    2010-10-01

    ... FOR THE ELDERLY (PACE) PACE Administrative Requirements § 460.71 Oversight of direct participant care... directly to participants demonstrate the skills necessary for performance of their position. (1) The PACE... PACE organization must develop a competency evaluation program that identifies those skills, knowledge...

  7. 22 CFR 96.32 - Internal structure and oversight.

    Science.gov (United States)

    2010-04-01

    ... selection, monitoring, and oversight of supervised providers. (e) The agency or person discloses to the accrediting entity the following information: (1) Any other names by which the agency or person is or has been... number of such other provider; and (3) The name, address, and phone number of any entity it uses or...

  8. Fiscal Year 2014: Comprehensive Oversight Plan for Southwest Asia

    Science.gov (United States)

    2013-09-30

    Accountability Office (GAO). This oversight community is committed to maintaining an effective working relationship to minimize duplication of efforts...four issues to better fit with drawdown concerns relating to U.S. personnel, property, fiduciary responsibility, and transition activities. 8

  9. Board oversight of quality: any differences in process of care and mortality?

    Science.gov (United States)

    Jiang, H Joanna; Lockee, Carlin; Bass, Karma; Fraser, Irene

    2009-01-01

    In response to legal and accreditation mandates as well as pressures from purchasers and consumers for quality improvement, hospital governing boards seek to improve their oversight of quality of care by adopting various practices. Based on a previous survey of hospital presidents/chief executive officers, this study examines differences in hospital quality performance associated with the adoption of particular practices in board oversight of quality. Quality was measured by performance in process of care and risk-adjusted mortality, using the Hospital Compare data from the Centers for Medicare & Medicaid Services and the Healthcare Cost and Utilization Project inpatient databases of the Agency for Healthcare Research and Quality. Board practices found to be associated with better performance in both process of care and mortality include (1) having a board quality committee; (2) establishing strategic goals for quality improvement; (3) being involved in setting the quality agenda for the hospital; (4) including a specific item on quality in board meetings; (5) using a dashboard with national benchmarks that includes indicators for clinical quality, patient safety, and patient satisfaction; and (6) linking senior executives' performance evaluation to quality and patient safety indicators. Involvement of physician leadership in the board quality committee further enhanced the hospital's quality performance. Taken together, these findings seem to support the will-execution-constancy of purpose framework on improving the effectiveness of hospital boards in overseeing quality. Future study should examine how specific board practices influence the culture and operations of the hospital that lead to better quality of care.

  10. Current practice and perspectives in CRO oversight based on a survey performed among members of the German Association of Research-Based Pharmaceutical Companies (vfa

    Directory of Open Access Journals (Sweden)

    Hennig, Michael

    2017-01-01

    Full Text Available In recent years, the number and scope of outsourced activities in the pharmaceutical industry have increased heavily. In addition, also the type of outsourcing has changed significantly in that time. This raises the question of whether and how sponsors retain the capability to select and to control the contract research organizations (CROs involved and what expertise still has to be present in the development department as well as other relevant departments to ensure adequate oversight, also in line with the expectations of regulators and health authorities. In order to answer these questions, a survey was conducted among the German vfa member companies. The survey describes the latest developments and experiences in outsourcing by 18 German vfa member companies. It concentrates on measures how to implement Quality Assurance (QA when performing outsourced clinical studies.This study shows that the majority of companies apply a full-outsourcing, preferred-provider model of clinical trial services, with the clinical research department playing the major role in this process. A large amount of guiding documents, processes and tools are used to ensure an adequate oversight of the services performed by the CRO(s.Finally the guiding principles for all oversight processes should be transparent communication, a clearly established expectation for quality, a precise definition of accountability and responsibility while avoiding silo mentality, and a comprehensive documentation of the oversight’s evidence. For globally acting and outsourcing sponsors, oversight processes need to be aligned with regards to local and global perspectives. This survey shows that the current implementation of oversight processes in the participating companies covers all relevant areas to ensure highest quality and integrity of the data produced by the outsourced clinical trial.

  11. Congressional Oversight of Homeland Security: Help or Hinderance?

    Science.gov (United States)

    2012-12-01

    gather the information required to conduct effective oversight many intelligence abuses ensued. The 1972 Watergate scandal was the event that...Political Science 28, no. 1 (1984): 166. 6 scandals or failures for its 65-year history. Although there have been instances where fire alarm...their findings. The Iran-Contra scandal occurred less than ten years later. Furthermore, the intelligence community’s slow adaptation to the post

  12. Nanotechnology, risk, and oversight: learning lessons from related emerging technologies.

    Science.gov (United States)

    Kuzma, Jennifer; Priest, Susanna

    2010-11-01

    Emerging technologies are defined by their novelty and thus are accompanied by significant uncertainty in determining appropriate ways to manage risks associated with them. Yet, there is a body of prior knowledge about risk management and oversight policy for other technologies that have already permeated society. Here, we describe two ways in which prospective oversight policy analysis for emerging technologies can draw upon these past experiences. One involves comparing specific products that have already been marketed to similar products of the emerging technology (cognate-product approach). The other treats the emerging technology as a body of products and methods and relates it to another technological field that has already emerged and penetrated markets (whole-technology approach). In this article, we describe our work using these approaches to inform risk and oversight policy for nanotechnology and its products. We draw parallels between biotechnology and nanotechnology as whole fields of development and also between genetically engineered organisms in the food supply and agricultural products of nanotechnology. Through these comparisons, we find that both approaches to historical learning have value and present lessons that could be applied to nanotechnology. © 2010 Society for Risk Analysis.

  13. Evaluating oversight systems for emerging technologies: a case study of genetically engineered organisms.

    Science.gov (United States)

    Kuzma, Jennifer; Najmaie, Pouya; Larson, Joel

    2009-01-01

    The U.S. oversight system for genetically engineered organisms (GEOs) was evaluated to develop hypotheses and derive lessons for oversight of other emerging technologies, such as nanotechnology. Evaluation was based upon quantitative expert elicitation, semi-standardized interviews, and historical literature analysis. Through an interdisciplinary policy analysis approach, blending legal, ethical, risk analysis, and policy sciences viewpoints, criteria were used to identify strengths and weaknesses of GEOs oversight and explore correlations among its attributes and outcomes. From the three sources of data, hypotheses and broader conclusions for oversight were developed. Our analysis suggests several lessons for oversight of emerging technologies: the importance of reducing complexity and uncertainty in oversight for minimizing financial burdens on small product developers; consolidating multi-agency jurisdictions to avoid gaps and redundancies in safety reviews; consumer benefits for advancing acceptance of GEO products; rigorous and independent pre- and post-market assessment for environmental safety; early public input and transparency for ensuring public confidence; and the positive role of public input in system development, informed consent, capacity, compliance, incentives, and data requirements and stringency in promoting health and environmental safety outcomes, as well as the equitable distribution of health impacts. Our integrated approach is instructive for more comprehensive analyses of oversight systems, developing hypotheses for how features of oversight systems affect outcomes, and formulating policy options for oversight of future technological products, especially nanotechnology products.

  14. Regulatory Oversight Program, July 1, 1993--March 3, 1997. Volume 2: Appendices

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    On July, 1993, a Regulatory Oversight (RO) organization was established within the US DOE, Oak Ridge Operations to provide regulatory oversight of the DOE uranium enrichment facilities leased to the United States Enrichment Corporation (USEC). The purpose of the OR program was to ensure continued plant safety, safeguards and security while the plants were transitioned to regulatory oversight by the Nuclear Regulatory Commission (NRC). Volume 2 contains copies of the documents which established the relationship between NRC, DOE, USEC, and DOL (Dept of Labor) required to facilitate regulatory oversight transition.

  15. Examining the FDA's oversight of direct-to-consumer advertising.

    Science.gov (United States)

    Gahart, Martin T; Duhamel, Louise M; Dievler, Anne; Price, Roseanne

    2003-01-01

    Our analysis examined the effects of the Food and Drug Administration's (FDA's) 1997 draft guidance regarding advertisements for prescription drugs broadcast directly to consumers. We found that although direct-to-consumer (DTC) advertising spending by pharmaceutical companies has increased, more than 80 percent of their promotional spending is directed to physicians. DTC advertising appears to increase the use of prescription drugs among consumers. The FDA's oversight has not prevented companies from making misleading claims in subsequent advertisements, and a recent policy change has lengthened the FDA's review process, raising the possibility that some misleading campaigns could run their course before review.

  16. 42 CFR 137.366 - May the Secretary conduct onsite project oversight visits?

    Science.gov (United States)

    2010-10-01

    ... Roles of the Secretary in Establishing and Implementing Construction Project Agreements § 137.366 May the Secretary conduct onsite project oversight visits? Yes, the Secretary may conduct onsite project... 42 Public Health 1 2010-10-01 2010-10-01 false May the Secretary conduct onsite project oversight...

  17. 75 FR 3509 - Public Company Accounting Oversight Board; Order Approving Proposed Rules on Auditing Standard No...

    Science.gov (United States)

    2010-01-21

    ...); 74 FR 57357 (November 5, 2009). II. Description Section 103 of the Act directs the Board, among other... COMMISSION Public Company Accounting Oversight Board; Order Approving Proposed Rules on Auditing Standard No..., 2009, the Public Company Accounting Oversight Board (the ``Board'' or the ``PCAOB'') filed with...

  18. 77 FR 76076 - Information Security Oversight Office; State, Local, Tribal, and Private Sector Policy Advisory...

    Science.gov (United States)

    2012-12-26

    ... RECORDS ADMINISTRATION Information Security Oversight Office; State, Local, Tribal, and Private Sector... Security Oversight Office. ACTION: Notice of meeting. SUMMARY: In accordance with the Federal Advisory... committee meeting of the State, Local, Tribal, and Private Sector Policy Advisory Committee. To discuss...

  19. 77 FR 2576 - Order Approving Public Company Accounting Oversight Board Budget and Annual Accounting Support...

    Science.gov (United States)

    2012-01-18

    ... Release No. 34-66141/January 11, 2012] Order Approving Public Company Accounting Oversight Board Budget and Annual Accounting Support Fee for Calendar Year 2012 The Sarbanes-Oxley Act of 2002, as amended (the ``Sarbanes-Oxley Act''),\\1\\ established the Public Company Accounting Oversight Board...

  20. 78 FR 11915 - Order Approving Public Company Accounting Oversight Board Budget and Annual Accounting Support...

    Science.gov (United States)

    2013-02-20

    ..., Release No. 68921/February 13, 2013] Order Approving Public Company Accounting Oversight Board Budget and Annual Accounting Support Fee for Calendar Year 2013 The Sarbanes-Oxley Act of 2002, as amended (the ``Sarbanes-Oxley Act''),\\1\\ established the Public Company Accounting Oversight Board (``PCAOB'') to...

  1. 75 FR 81684 - Order Approving Public Company Accounting Oversight Board Budget and Annual Accounting Support...

    Science.gov (United States)

    2010-12-28

    ...; Release No. 34-63596/December 22, 2010] Order Approving Public Company Accounting Oversight Board Budget and Annual Accounting Support Fee for Calendar Year 2011 The Sarbanes-Oxley Act of 2002, as amended (the ``Sarbanes-Oxley Act''), established the Public Company Accounting Oversight Board (``PCAOB'')...

  2. 75 FR 51280 - Oversight of Laboratory Developed Tests; Public Meeting; Reopening of the Comment Period

    Science.gov (United States)

    2010-08-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration Oversight of Laboratory Developed Tests; Public Meeting... oversight of laboratory developed tests (LDTs). FDA is reopening the comment period to update comments...

  3. Creating a Learning Organization in Law Enforcement: Maturity Levels for Police Oversight Agencies

    Science.gov (United States)

    Filstad, Cathrine; Gottschalk, Petter

    2010-01-01

    Purpose: The purpose of this paper is to conceptualize a stage model for maturity levels for police oversight agencies. Design/methodology/approach: The paper is based on a literature review covering police oversight organizations and stages of growth models. Findings: As a conceptual paper, the main findings are related to the appropriateness of…

  4. 76 FR 31416 - Federal Acquisition Regulation; Oversight of Contractor Ethics Programs

    Science.gov (United States)

    2011-05-31

    ... Federal Acquisition Regulation; Oversight of Contractor Ethics Programs AGENCY: Department of Defense (DoD... contractors have implemented the mandatory contractor business ethics program requirements. DATES: Effective... to Improve DoD's Oversight of Contractor Ethics Programs. The ethics program requirement flows from...

  5. 48 CFR 52.236-24 - Work Oversight in Architect-Engineer Contracts.

    Science.gov (United States)

    2010-10-01

    ... Architect-Engineer Contracts. 52.236-24 Section 52.236-24 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.236-24 Work Oversight in Architect-Engineer Contracts. As prescribed in 36.609-3, insert the following clause: Work Oversight in Architect-Engineer Contracts (APR 1984) The extent...

  6. Psychotropic Medication Management for Youth in State Care: Consent, Oversight, and Policy Considerations

    Science.gov (United States)

    Naylor, Michael W.; Davidson, Christine V.; Ortega-Piron, D. Jean; Bass, Arin; Gutierrez, Alice; Hall, Angela

    2007-01-01

    The use of psychotropic medications in youth with emotional disturbances in state custody is increasing and presents unique challenges concerning consent and oversight. We examine various means that state child welfare agencies use to provide consent for and oversight of psychotropic medications for children in state custody and describe benefits…

  7. Real-time Responsiveness for Ethics Oversight During Disaster Research.

    Science.gov (United States)

    Eckenwiler, Lisa; Pringle, John; Boulanger, Renaud; Hunt, Matthew

    2015-11-01

    Disaster research has grown in scope and frequency. Research in the wake of disasters and during humanitarian crises--particularly in resource-poor settings--is likely to raise profound and unique ethical challenges for local communities, crisis responders, researchers, and research ethics committees (RECs). Given the ethical challenges, many have questioned how best to provide research ethics review and oversight. We contribute to the conversation concerning how best to ensure appropriate ethical oversight in disaster research and argue that ethical disaster research requires of researchers and RECs a particular sort of ongoing, critical engagement which may not be warranted in less exceptional research. We present two cases that typify the concerns disaster researchers and RECs may confront, and elaborate upon what this ongoing engagement might look like--how it might be conceptualized and utilized--using the concept of real-time responsiveness (RTR). The central aim of RTR, understood here as both an ethical ideal and practice, is to lessen the potential for research conducted in the wake of disasters to create, perpetuate, or exacerbate vulnerabilities and contribute to injustices suffered by disaster-affected populations. Well cultivated and deployed, we believe that RTR may enhance the moral capacities of researchers and REC members, and RECs as institutions where moral agency is nurtured and sustained.

  8. The Capability to Hold Property

    NARCIS (Netherlands)

    Claassen, Rutger|info:eu-repo/dai/nl/269266224

    2015-01-01

    This paper discusses the question of whether a capability theory of justice (such as that of Martha Nussbaum) should accept a basic “capability to hold property.” Answering this question is vital for bridging the gap between abstract capability theories of justice and their institutional implication

  9. 75 FR 81405 - Portfolio Holdings

    Science.gov (United States)

    2010-12-28

    ... portfolio parameters in response to conditions in the market. Related to the process of adjusting the..., Office of the General Counsel, (202) 414-3798, or Valerie Smith, Office of Policy Analysis and Research... to provide a liquid secondary market through securitization activities, the portfolio holdings...

  10. The Capability to Hold Property

    NARCIS (Netherlands)

    Claassen, Rutger|info:eu-repo/dai/nl/269266224

    2015-01-01

    This paper discusses the question of whether a capability theory of justice (such as that of Martha Nussbaum) should accept a basic “capability to hold property.” Answering this question is vital for bridging the gap between abstract capability theories of justice and their institutional

  11. 32 CFR 2004.10 - Responsibilities of the Director, Information Security Oversight Office (ISOO) [102(b)]. 1

    Science.gov (United States)

    2010-07-01

    ... Security Oversight Office (ISOO) . 1 2004.10 Section 2004.10 National Defense Other Regulations Relating to National Defense INFORMATION SECURITY OVERSIGHT OFFICE, NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NATIONAL INDUSTRIAL SECURITY PROGRAM DIRECTIVE NO. 1 Implementation and Oversight § 2004.10...

  12. 75 FR 72816 - Public Input for the Study Regarding the Oversight of Existing and Prospective Carbon Markets

    Science.gov (United States)

    2010-11-26

    ... COMMISSION Public Input for the Study Regarding the Oversight of Existing and Prospective Carbon Markets... Commission (the ``CFTC''), to conduct a study on the oversight of existing and prospective carbon markets to... to study the oversight of existing and prospective carbon markets. The interagency group is composed...

  13. A qualitative phenomenological study: Enhanced, risk-based FAA oversight on part 145 maintenance practices

    Science.gov (United States)

    Sheehan, Bryan G.

    The purpose of this qualitative phenomenological study was to examine the phenomenon of enhanced, risk-based Federal Aviation Administration (FAA) oversight of Part 145 repair stations that performed aircraft maintenance for Part 121 air carriers between 2007 and 2014 in Oklahoma. Specifically, this research was utilized to explore what operational changes have occurred in the domestic Part 145 repair station industry such as variations in management or hiring practices, training, recordkeeping and technical data, inventory and aircraft parts supply-chain logistics, equipment, and facilities. After interviewing 12 managers from Part 145 repair stations in Oklahoma, six major theme codes emerged from the data: quality of oversight before 2007, quality of oversight after 2007, advantages of oversight, disadvantages of oversight, status quo of oversight, and process improvement . Of those six major theme codes, 17 subthemes appeared from the data that were used to explain the phenomenon of enhanced oversight in the Part 145 repair station industry. Forty-two percent of the participants indicated a weak FAA oversight system that has hindered the continuous process improvement program in their repair stations. Some of them were financially burdened after hiring additional full-time quality assurance inspectors to specifically manage enhanced FAA oversight. Notwithstanding, the participants of the study indicated that the FAA must apply its surveillance on a more standardized and consistent basis. They want to see this standardization in how FAA inspectors interpret regulations and practice the same quality of oversight for all repair stations, particularly those that are repeat violators and fail to comply with federal aviation regulations. They believed that when the FAA enforces standardization on a consistent basis, repair stations can become more efficient and safer in the performance of their scope of work for the U.S. commercial air transportation industry.

  14. Fish Hold Effluent and Fish Hold Cleaning Wastewater Discharge

    Science.gov (United States)

    2011-11-01

    summarized in Table 1). EPA estimated that mid-size fishing vessels, such as gill netters , and purse seiners found in Alaska, and shrimp boats in the Gulf...size fishing boats such as gill netters , fish holds are typically cleaned using a garden hose at a flow rate of approximately 10 to 12 gpm (USEPA...Small: salmon trollers and longliners 1,500 Daily when fishing 500 - 600 150 - 200 Mid-size: gill netters , purse seiners and shrimp boats

  15. Regulatory oversight of nuclear safety in Finland. Annual report 2011

    Energy Technology Data Exchange (ETDEWEB)

    Kainulainen, E. (ed.)

    2012-07-01

    The report constitutes the report on regulatory control in the field of nuclear energy which the Radiation and Nuclear Safety Authority (STUK) is required to submit once a year to the Ministry of Employment and the Economy pursuant to Section 121 of the Nuclear Energy Decree. The report is also delivered to the Ministry of Environment, the Finnish Environment Institute, and the regional environmental authorities of the localities in which a nuclear facility is located. The regulatory control of nuclear safety in 2011 included the design, construction and operation of nuclear facilities, as well as nuclear waste management and nuclear materials. The first parts of the report explain the basics of nuclear safety regulation included as part of STUK's responsibilities, as well as the objectives of the operations, and briefly introduce the objects of regulation. The chapter concerning the development and implementation of legislation and regulations describes changes in nuclear legislation, as well as the progress of STUK's YVL Guide revision work. The section concerning the regulation of nuclear facilities contains an overall safety assessment of the nuclear facilities currently in operation or under construction. The chapter concerning the regulation of the final disposal project for spent nuclear fuel de-scribes the preparations for the final disposal project and the related regulatory activities. The section concerning nuclear non-proliferation describes the nuclear non-proliferation control for Finnish nuclear facilities and final disposal of spent nuclear fuel, as well as measures required by the Additional Protocol of the Safeguards Agreement. The chapter describing the oversight of security arrangements in the use of nuclear energy discusses oversight of the security arrangements in nuclear power plants and other plants, institutions and functions included within the scope of STUK's regulatory oversight. The chapter also discusses the national and

  16. Optimization of Holding Temperature and Holding Thickness for Controlled Rolling on Plate Mill

    Institute of Scientific and Technical Information of China (English)

    HU Xian-lei; ZHAO Zhong; WANG Jun; WANG Zhao-dong; LIU Xiang-hua; WANG Guo-dong

    2006-01-01

    Holding temperature and holding thickness are main parameters for two-phase controlled rolling on plate mill. The optimization of holding temperature and holding thickness for pass schedule calculation of two-phase controlled rolling on plate mill was presented and its feature is as follows: (1) Determination of holding thickness can be automatically obtained based on the influence of mill safety limits, tracking zone length and holding time on holding thickness; (2) Determination of holding temperature can be automatically obtained and the holding time can be reduced as much as possible; (3) Algorithm can modify the holding temperature and thickness depending on slab size and product size.

  17. SPECIALIZATION AND SUSTAINABLE DEVELOPMENT OF AGRICULTURAL HOLDINGS

    Directory of Open Access Journals (Sweden)

    Zofia Kołoszko-Chomentowska

    2016-03-01

    Full Text Available In the present article, an attempt was made to assess the sustainability of agricultural holdings with diff erent directions of production. Agricultural holdings in the Podlaskie voivodeship registered in the FADN system in 2011–2012 were investigated. Assessment accounted for agroecological indicators (share of permanent grasslands, share of cereals in crops, soil coverage with vegetation, stock density and economic indicators (profi tableness of land and labor. Analysis was conducted according to a classifi cation into agricultural holding types: fi eldcrops, dairy cattle, and granivores. Fieldcrop and granivore holdings achieved more favourable environmental sustainability indicators. Holdings specializing in dairy cattle breeding posed a threat to the natural environment, mainly due to their excessive stock density. Economic sustainability assessment showed that granivore holdings were assessed most favorably. In these holdings, holding income per full-time worker was 37% greater than in fi eldcrop holdings and 57% greater than in dairy cattle holdings.

  18. China Rare Earth Holdings Limited

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    China Rare Earth Holdings Limited is a large trans-area corporation and a public company listed in Hong Kong Stock Exchange (Name: China Rare Earth, Code: 0769), with headquarter in Hong Kong. Located on the bank of beautiful Taihu Lake, the subsidiary in Yinxing covers area of 200,000 m2. It has nearly 1,000 employees, 30% of whom are technical staffs. After self-administration and effort, the company passed ISO 9001: 2000 and ISO 14000 Certificaitons.

  19. Holding Costs and Equilibrium Arbitrage

    OpenAIRE

    Tuckman, Bruce; Vila, Jean-Luc

    1993-01-01

    This paper constructs a dynamic model of the equilibrium determination of relative prices when arbitragers face holding costs. The major findings are that 1) models based on riskless arbitrage arguments alone may not provide usefully tight bounds on observed prices, 2) arbitragers are often most effective in eliminating the mispricings of shorter-term assets, 3) arbitrage activity increases the mean reversion of changes in the mispricing process and reduces their conditional volatility, and 4...

  20. External Police Oversight in Mexico: Experiences, Challenges, and Lessons Learned

    Directory of Open Access Journals (Sweden)

    Rubén Guzmán Sánchez

    2014-11-01

    Full Text Available After nearly 20 years of ‘reformist’ measures, the police in Mexico continues to be an ineffective, unreliable, and ‘far from citizen’ institution. The efforts made so far have faded amongst political interests and agendas; multidimensional frameworks out-dated at both conceptual and interagency levels; short-sighted competition for resources; evaluation and performance monitors that are handicapped by bureaucratic inaction; and weak transparency and accountability that perpetuate the opacity in which the police operate. In this context, the agenda of external police oversight is still at a rudimentary stage. However, there are several initiatives that have managed to push the issue to the frontier of new knowledge and promising practices. This paper outlines the experiences and challenges of—as well as the lessons learned by—the Institute for Security and Democracy (Insyde A.C., one of the most recognised think tanks in Mexico.

  1. Tennessee Oversight Agreement combined annual reports, May 13, 1991--May 12, 1993

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-07-01

    The Tennessee Oversight Agreement provides independent oversight and monitoring of the Department of Energy`s activities on the Oak Ridge Reservation by the State. The agreement obligates the state to provide an annual report to DOE and for public distribution of the results of the DOE Oversight Division`s monitoring and analysis activities and its findings of the quality and effectiveness of the Department of Energy`s environmental monitoring and surveillance programs. The DOE Oversight Division`s first report will discuss the status of the entire oversight agreement for the first two years of its existence. The 1991--1993 combined annual reports include a short history of the Division, a list of the Tennessee Oversight Agreement commitments and a status report on each of DOE Oversight Division`s programs. Each Division program includes a descriptive status of its findings and recommendations. These findings and recommendations were also consolidated into a separate segment of the report (Chapter 7). Findings indicate there have been genuine successes in the areas of site access and data availability. More effort, however, is required in both of these areas before the state can verify that DOE and its contractors are meeting its obligations. Ambient surveillance monitoring by DOE is extensive. The DOE Oversight Division reviews this data to assure the state and its citizens that all areas of the environment are adequately protected by DOE operations. There is a noticeable lack of research and development in the technology for environmental remediation and radiological and mixed waste treatment, storage and disposal. The DOE Oversight Division`s recommendations for improvement are provided with each of the findings listed in this report.

  2. Recombinant allergens: what does the future hold?

    Science.gov (United States)

    Valenta, Rudolf; Niespodziana, Katarzyna; Focke-Tejkl, Margit; Marth, Katharina; Huber, Hans; Neubauer, Angela; Niederberger, Verena

    2011-04-01

    This year we are celebrating not only the centenary of allergen-specific immunotherapy but also the 10-year anniversary of the first administration of recombinant allergen-based vaccines to allergic patients. By using recombinant DNA technology, defined and safe allergy vaccines can be produced that allow us to overcome many, if not all, of the problems associated with the use of natural allergen extracts, such as insufficient quality, allergenic activity, and poor immunogenicity. Here we provide an update of clinical studies with recombinant allergen-based vaccines, showing that some of these vaccines have undergone successful clinical evaluation up to phase III studies. Furthermore, we introduce a strategy for allergen-specific immunotherapy based on recombinant fusion proteins consisting of viral carrier proteins and allergen-derived peptides without allergenic activity, which holds the promise of being free of side effects and eventually being useful for prophylactic vaccination.

  3. Improvements Needed in Managing Scope Changes and Oversight of Construction Projects at Camp Lemonnier, Djibouti

    Science.gov (United States)

    2016-09-30

    Improvements Needed in Managing Scope Changes and Oversight of Construction Projects at Camp Lemonnier, Djibouti S E P T E M B E R 3 0 , 2 0 1 6 Report...Improvements Needed in Managing Scope Changes and Oversight of Construction Projects at Camp Lemonnier, Djibouti Visit us at www.dodig.mil Objective We...Findings (cont’d) ii │ DODIG-2016-141 (Project No. D2014-D000RE-0157.000) Results in Brief Improvements Needed in Managing Scope Changes and Oversight

  4. Do More Economists Hold Stocks?

    DEFF Research Database (Denmark)

    Christiansen, Charlotte; Joensen, Juanna Schröter; Rangvid, Jesper

    , even when controlling for several background characteristics. We make use of a large register-based panel data set containing detailed information on the educational attainments and various financial and socioeconomic variables. We model the stock market participation decision by the probit model......A unique data set enables us to test the hypothesis that more economists than otherwise identical investors hold stocks due to informational advantages. We confirm that economists have a significantly higher probability of participating in the stock market than investors with any other education...

  5. Determinants of agricultural holdings sustainability

    Directory of Open Access Journals (Sweden)

    Wioletta Wrzaszcz

    2012-04-01

    Full Text Available Agricultural policy in the European Union, at the Community level, as well as Member Countries, increasingly emphasize the issue of sustainable development of agriculture. This is a response to the multiplying threats to the environment. Referring to this problem, it was justified to estimate the level of agricultural holdings sustainability (on the basis of FADN data and recognize its determinants. There was applied multidimensional statistical analysis and logistic regression. The research indicated that identification of environmentally friendly agriculture with low profit production is ungrounded.

  6. Regulatory Oversight Program, July 1, 1993--March 3, 1997. Volume 3

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    On July, 1993, a Regulatory Oversight (RO) organization was established within the US DOE, Oak Ridge Operations (ORO) to provide regulatory oversight of the DOE uranium enrichment facilities leased to the United States Enrichment Corporation (USEC). The purpose of the OR program was to ensure continued plant safety, safeguards and security while the plants were transitioned to regulatory oversight by the Nuclear Regulatory Commission (NRC). Volume 3 contains copies of two reports that document the DOE/ORO regulatory oversight inspection and enforcement history for each gaseous diffusion plant site. Each report provides a formal mechanism by which DOE/ORO could communicate the inspection and enforcement history to NRC. The reports encompass the inspection activities that occurred during July 1, 1993 through March 2, 1997.

  7. 77 FR 71803 - Guidance on Food and Drug Administration Oversight of Positron Emission Tomography Drug Products...

    Science.gov (United States)

    2012-12-04

    ... HUMAN SERVICES Food and Drug Administration Guidance on Food and Drug Administration Oversight of... Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the... surveillance processes, including application submission, review, compliance with good manufacturing...

  8. Support for Afghanistan’s Justice Sector: State Department Programs Need Better Management and Stronger Oversight

    Science.gov (United States)

    2014-01-01

    component from the contractor that previously implemented the JSSP— PAE Incorporated ( PAE )—to IDLO. This audit assesses (1) INL’s management of...from PAE to IDLO affects INL’ s oversight of the program, and (3) State’s efforts to coordinate justice sector programs in Afghanistan across...management and oversight of the Justice Sector Support Program (JSSP) contract with PAE Incorporated ( PAE ) limited its ability to assess the

  9. Creating a learning organization in law enforcement: Maturity levels for police oversight agencies

    OpenAIRE

    Filstad, Cathrine; Gottschalk, Petter

    2010-01-01

    Purpose – The purpose of this paper is to conceptualize a stage model for maturity levels for police oversight agencies. Design/methodology/approach – The paper is based on a literature review covering police oversight organizations and stages of growth models. Findings – As a conceptual paper, the main findings are related to the appropriateness of the stage model, each identified stage, and the characteristics of each stage. Research limitations/implications – An empirical...

  10. Allowance Holdings and Transfers Data Inventory

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Allowance Holdings and Transfers Data Inventory contains measured data on holdings and transactions of allowances under the NOx Budget Trading Program (NBP), a...

  11. 76 FR 36625 - Mutual Holding Company

    Science.gov (United States)

    2011-06-22

    ... Office of Thrift Supervision Mutual Holding Company AGENCY: Office of Thrift Supervision (OTS), Treasury... collection. Title of Proposal: Mutual Holding Company. OMB Number: 1550-0072. Form Numbers: MHC-1 (OTS Form... whether the applicant meets the statutory and regulatory criteria to form a mutual holding company...

  12. 76 FR 20458 - Mutual Holding Company

    Science.gov (United States)

    2011-04-12

    ... Office of Thrift Supervision Mutual Holding Company AGENCY: Office of Thrift Supervision (OTS), Treasury... collection. Title of Proposal: Mutual Holding Company. OMB Number: 1550-0072. Form Numbers: MHC-1 (OTS Form... whether the applicant meets the statutory and regulatory criteria to form a mutual holding company...

  13. Functional Analysis and Intervention for Breath Holding.

    Science.gov (United States)

    Kern, Lee; And Others

    1995-01-01

    A functional analysis of breath-holding episodes in a 7-year-old girl with severe mental retardation and Cornelia-de-Lange syndrome indicated that breath holding served an operant function, primarily to gain access to attention. Use of extinction, scheduled attention, and a picture card communication system decreased breath holding. (Author/SW)

  14. 47 CFR 73.7005 - Holding period.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Holding period. 73.7005 Section 73.7005... Applications for Noncommercial Educational Stations on Non-Reserved Channels § 73.7005 Holding period. (a... holding period. From the grant of the construction permit and continuing until the facility has achieved...

  15. 9 CFR 2.101 - Holding period.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Holding period. 2.101 Section 2.101... WELFARE REGULATIONS Compliance With Standards and Holding Period § 2.101 Holding period. (a) Any live dog... and control, for a period of not less than 5 full days, not including the day of acquisition, after...

  16. A LITERATURE REVIEW OF COMPANIES CASH HOLDINGS

    Directory of Open Access Journals (Sweden)

    Iuliana Oana Mihai

    2015-05-01

    Full Text Available The purpose of this article is to investigate the scientific literature related to cash holdings of non-financial companies. We concentrated in our work on motives, determinants and theories of cash holding. The result of this study will enhance understanding of cash holding determinants and relevance of postulated theories in Romanian context. The main objective is to.

  17. Achieving clinical integration.

    Science.gov (United States)

    Redding, John

    2013-11-01

    To develop an effective and sustainable clinically integrated network (CIN) that positions a healthcare organization for value-based payment and other effects of healthcare reform, leaders of CIN initiatives should: Embrace progress rather than perfection; Constrain the development timeline by project managing in reverse; Ensure that physician leaders play an oversight role in the development process.

  18. Recommendations for nanomedicine human subjects research oversight: an evolutionary approach for an emerging field.

    Science.gov (United States)

    Fatehi, Leili; Wolf, Susan M; McCullough, Jeffrey; Hall, Ralph; Lawrenz, Frances; Kahn, Jeffrey P; Jones, Cortney; Campbell, Stephen A; Dresser, Rebecca S; Erdman, Arthur G; Haynes, Christy L; Hoerr, Robert A; Hogle, Linda F; Keane, Moira A; Khushf, George; King, Nancy M P; Kokkoli, Efrosini; Marchant, Gary; Maynard, Andrew D; Philbert, Martin; Ramachandran, Gurumurthy; Siegel, Ronald A; Wickline, Samuel

    2012-01-01

    The nanomedicine field is fast evolving toward complex, "active," and interactive formulations. Like many emerging technologies, nanomedicine raises questions of how human subjects research (HSR) should be conducted and the adequacy of current oversight, as well as how to integrate concerns over occupational, bystander, and environmental exposures. The history of oversight for HSR investigating emerging technologies is a patchwork quilt without systematic justification of when ordinary oversight for HSR is enough versus when added oversight is warranted. Nanomedicine HSR provides an occasion to think systematically about appropriate oversight, especially early in the evolution of a technology, when hazard and risk information may remain incomplete. This paper presents the consensus recommendations of a multidisciplinary, NIH-funded project group, to ensure a science-based and ethically informed approach to HSR issues in nanomedicine, and to integrate HSR analysis with analysis of occupational, bystander, and environmental concerns. We recommend creating two bodies, an interagency Human Subjects Research in Nanomedicine (HSR/N) Working Group and a Secretary's Advisory Committee on Nanomedicine (SAC/N). HSR/N and SAC/N should perform 3 primary functions: (1) analysis of the attributes and subsets of nanomedicine interventions that raise HSR challenges and current gaps in oversight; (2) providing advice to relevant agencies and institutional bodies on the HSR issues, as well as federal and federal-institutional coordination; and (3) gathering and analyzing information on HSR issues as they emerge in nanomedicine. HSR/N and SAC/N will create a home for HSR analysis and coordination in DHHS (the key agency for relevant HSR oversight), optimize federal and institutional approaches, and allow HSR review to evolve with greater knowledge about nanomedicine interventions and greater clarity about attributes of concern.

  19. ALICE Holds Up to Challenge

    CERN Multimedia

    2006-01-01

    ALICE's main austenitic stainless steel support structure (the Space Frame) has recently gone through many tests that proved quite challenging: insuring the structure is sound and lowering it horizontally into the ALICE cavern. This structure is constructed to hold the large volume detectors, such as the Time Projection Chamber, Transition Radiation Detector and Time of Flight inside the ALICE solenoid magnet. After the final assembly at CERN, two large mobile cranes were needed for the job of lifting and turning the 14 tonne frame onto its side. Once shifted, it was placed in Building SX2, one of the surface assembly areas designated for ALICE. The structure, which is 8 m in diameter and 7 m long, underwent many tests in its new position. Geometric control tests were performed by measuring each of the 18 cells and placing wooden or metal samples constructed to the same dimensions as the real thing inside the structure. The most important check was the movement of the real Time Projection Chamber from its s...

  20. Breath-holding and its breakpoint.

    Science.gov (United States)

    Parkes, M J

    2006-01-01

    This article reviews the basic properties of breath-holding in humans and the possible causes of the breath at breakpoint. The simplest objective measure of breath-holding is its duration, but even this is highly variable. Breath-holding is a voluntary act, but normal subjects appear unable to breath-hold to unconsciousness. A powerful involuntary mechanism normally overrides voluntary breath-holding and causes the breath that defines the breakpoint. The occurrence of the breakpoint breath does not appear to be caused solely by a mechanism involving lung or chest shrinkage, partial pressures of blood gases or the carotid arterial chemoreceptors. This is despite the well-known properties of breath-hold duration being prolonged by large lung inflations, hyperoxia and hypocapnia and being shortened by the converse manoeuvres and by increased metabolic rate. Breath-holding has, however, two much less well-known but important properties. First, the central respiratory rhythm appears to continue throughout breath-holding. Humans cannot therefore stop their central respiratory rhythm voluntarily. Instead, they merely suppress expression of their central respiratory rhythm and voluntarily 'hold' the chest at a chosen volume, possibly assisted by some tonic diaphragm activity. Second, breath-hold duration is prolonged by bilateral paralysis of the phrenic or vagus nerves. Possibly the contribution to the breakpoint from stimulation of diaphragm muscle chemoreceptors is greater than has previously been considered. At present there is no simple explanation for the breakpoint that encompasses all these properties.

  1. A Study on the Construct Validity of Safety Culture Oversight Model for Nuclear Power Operating Organization

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Su Jin; Choi, Young Sung; Oh, Jang Jin [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2015-05-15

    In Korea, the safety policy statement declared in 1994 by government stressed the importance of safety culture and licensees were encouraged to manage and conduct their self-assessments. A change in regulatory position about safety culture oversight was made after the event of SBO cover-up in Kori unit 1 and several subsequent falsification events. Since then KINS has been developing licensee's safety culture oversight system including conceptual framework of oversight, prime focus area for oversight, and specific details on regulatory expectations, all of which are based on defence-in-depth (DiD) safety enhancement approach. Development and gathering of performance data which is related to actual 'safety' of nuclear power plant are needed to identify the relationship between safety culture and safety performance. Authors consider this study as pilot which has a contribution on verifying the construct validity of the model and the effectiveness of survey based research. This is the first attempt that the validity of safety culture oversight model has been investigated with empirical data obtained from Korean nuclear power operating organization.

  2. Clinical evaluation of X-ray voxel Monte Carlo versus pencil beam-based dose calculation in stereotactic body radiotherapy of lung cancer under normal and deep inspiration breath hold.

    Science.gov (United States)

    Landoni, V; Borzì, G R; Strolin, S; Bruzzaniti, V; Soriani, A; D'Alessio, D; Ambesi, F; Di Grazia, A M; Strigari, L

    2015-06-01

    The purpose of this study is to evaluate the differences between dose distributions calculated with the pencil beam (PB) and X-ray voxel Monte Carlo (MC) algorithms for patients with lung cancer using intensity-modulated radiotherapy (IMRT) or HybridArc techniques. The 2 algorithms were compared in terms of dose-volume histograms, under normal and deep inspiration breath hold, and in terms of the tumor control probability (TCP). The dependence of the differences in tumor volume and location was investigated. Dosimetric validation was performed using Gafchromic EBT3 (International Specialty Products, ISP, Wayne, NJ). Forty-five Computed Tomography (CT) data sets were used for this study; 40 Gy at 8 Gy/fraction was prescribed with 5 noncoplanar 6-MV IMRT beams or 3 to 4 dynamic conformal arcs with 3 to 5 IMRT beams distributed per arc. The plans were first calculated with PB and then recalculated with MC. The difference between the mean tumor doses was approximately 10% ± 4%; these differences were even larger under deep inspiration breath hold. Differences between the mean tumor dose correlated with tumor volume and path length of the beams. The TCP values changed from 99.87% ± 0.24% to 96.78% ± 4.81% for both PB- and MC-calculated plans (P = .009). When a fraction of hypoxic cells was considered, the mean TCP values changed from 76.01% ± 5.83% to 34.78% ± 18.06% for the differently calculated plans (P < .0001). When the plans were renormalized to the same mean dose at the tumor, the mean TCP for oxic cells was 99.05% ± 1.59% and for hypoxic cells was 60.20% ± 9.53%. This study confirms that the MC algorithm adequately accounts for inhomogeneities. The inclusion of the MC in the process of IMRT optimization could represent a further step in the complex problem of determining the optimal treatment plan.

  3. What does the history of technology regulation teach us about nano oversight?

    Science.gov (United States)

    Marchant, Gary E; Sylvester, Douglas J; Abbott, Kenneth W

    2009-01-01

    As policy makers struggle to develop regulatory oversight models for nanotechnologies, there are important lessons that can be drawn from previous attempts to govern other emerging technologies. Five such lessons are the following: (1) public confidence and trust in a technology and its regulatory oversight is probably the most important factor for the commercial success of a technology; (2) regulation should avoid discriminating against particular technologies unless there is a scientifically based rationale for the disparate treatment; (3) regulatory systems need to be flexible and adaptive to rapidly changing technologies; (4) ethical and social concerns of the public about emerging technologies need to be expressly acknowledged and addressed in regulatory oversight; and (5) international harmonization of regulation may be beneficial in a rapidly globalizing world.

  4. 42 CFR 137.368 - Is the Secretary responsible for oversight and compliance of health and safety codes during...

    Science.gov (United States)

    2010-10-01

    ... SELF-GOVERNANCE Construction Roles of the Secretary in Establishing and Implementing Construction Project Agreements § 137.368 Is the Secretary responsible for oversight and compliance of health and... 42 Public Health 1 2010-10-01 2010-10-01 false Is the Secretary responsible for oversight and...

  5. Defense Space Acquisitions: Too Early to Determine if Recent Changes Will Resolve Persistent Fragmentation in Management and Oversight

    Science.gov (United States)

    2016-07-27

    Unified leadership and authority, Planning) 12. Change Air Force and intelligence community (IC) human resource management policies for space...Space Acquisitions: Too Early to Determine If Recent Changes Will Resolve Persistent Fragmentation in Management and Oversight The Department of...over two decades that fragmentation and overlap in DOD space acquisition management and oversight have contributed to program delays and cancellations

  6. Holdings as a Measure of Journal Value.

    Science.gov (United States)

    Wallace, Danny P.; Boyce, Bert R.

    1989-01-01

    Describes a study that compared holdings figures from the OCLC database to productivity measures from the "Journal Citation Reports" section of "Science Citation Index" and publisher circulation figures to determine whether there is a systematic relationship between easily gathered holdings and circulation figures and less…

  7. Course holding by cyclists and moped riders.

    NARCIS (Netherlands)

    Godthelp, J. & Wouters, P.I.J.

    1980-01-01

    Course holding by cyclists and moped riders includes both steering alongside a course and stabilising the vehicle. Inability to hold course may lead to conflicts with other road users. To design safe bicycle and moped facilities and to consider the safety of those existing, knowledge about performan

  8. Error-Compensated Integrate and Hold

    Science.gov (United States)

    Matlin, M.

    1984-01-01

    Differencing circuit cancels error caused by switching transistors capacitance. In integrate and hold circuit using JFET switch, gate-to-source capacitance causes error in output voltage. Differential connection cancels out error. Applications in systems where very low voltages sampled or many integrate-and -hold cycles before circuit is reset.

  9. Inflation, operating cycle, and cash holdings

    Institute of Scientific and Technical Information of China (English)

    Yanchao; Wang; Yu; Ji; Xu; Chen; Chunlei; Song

    2014-01-01

    A corporate cash-holding strategy is a trade-off between the costs and benefits of holding cash.At the macrolevel,firms are inclined to adjust and optimize their cash-holding strategies in response to changes in purchasing power due to inflation.At the microlevel,the operating cycle,which indicates the speed and turnover of corporate cash flow,also influences the corporate cash-holding strategy.Firms flexibly adjust their cash-holding strategies in response to changes in the internal and external environment,which is referred to as the cash adjustment strategy.We examine these predicted relationships using a sample of listed firms in China’s stock market over the 1998–2009 period.Consistent with our predictions,the empirical results indicate a significant negative association between cash holdings and the CPI,but the relationship is reversed when the CPI reaches a certain level.There is also a U-shaped relationship between operating cycle and cash holdings,and this relationship is similarly influenced by changes in the inflation level.In examining the macroeconomic environment and microlevel firm-specific characteristics simultaneously,our findings supplement the literature on firms’cash-holding strategies and provide theoretical and practical implications.

  10. Evaluating oversight of human drugs and medical devices: a case study of the FDA and implications for nanobiotechnology.

    Science.gov (United States)

    Paradise, Jordan; Tisdale, Alison W; Hall, Ralph F; Kokkoli, Efrosini

    2009-01-01

    This article evaluates the oversight of drugs and medical devices by the U.S. Food and Drug Administration (FDA) using an integration of public policy, law, and bioethics approaches and employing multiple assessment criteria, including economic, social, safety, and technological. Criteria assessment and expert elicitation are combined with existing literature, case law, and regulations in an integrative historical case studies approach. We then use our findings as a tool to explore possibilities for effective oversight and regulatory mechanisms for nanobiotechnology. Section I describes oversight mechanisms for human drugs and medical devices and presents current nanotechnology products. Section II describes the results of expert elicitation research. Section III highlights key criteria and relates them to the literature and larger debate. We conclude with broad lessons for the oversight of nanobiotechnology informed by Sections I-III in order to provide useful analysis from multiple disciplines and perspectives to guide discussions regarding appropriate FDA oversight.

  11. Piracetam in severe breath holding spells.

    Science.gov (United States)

    Azam, Matloob; Bhatti, Nasera; Shahab, Naheed

    2008-01-01

    Breath holding spells (BHS) are apparently frightening events occurring in otherwise healthy children. Generally, no medical treatment is recommended and parental reassurance is believed to be enough, however, severe BHS can be very stressful for the parents and a pharmacological agent may be desired in some of these children. In this prospective study aim was to determine the usefulness of piracetam as prophylactic treatment for severe BHS. Children were recruited from Neurology Clinic in Children's Hospital, Islamabad between January 2002 to December 2004. Diagnosis of BHS was based on characteristic history and normal physical examination. Piracetam was prescribed to those children who were diagnosed as severe BHS in a dose ranging from 50-100 mg/kg/day. Iron supplements were added if hemoglobin was less than 10 gm%. Patients were seen at 2-4 weeks interval and follow-up was continued until 3 months after the cessation of drug therapy. Fifty-two children were enrolled in the study, 34 boys and 18 girls. Ages ranged from 4 weeks to 5 years with mean age of 17 months. In 81% of children, spells disappeared completely and in 9% frequency was reduced to less than one per month and of much lesser intensity. Prophylaxis was given for 3-6 months (mean 5) duration. Piracetam is an effective prophylactic treatment for severe BHS.

  12. 78 FR 66097 - Acies Corporation, Immtech Pharmaceuticals, Inc., MRU Holdings, Inc., MSTI Holdings, Inc., Nestor...

    Science.gov (United States)

    2013-11-04

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Acies Corporation, Immtech Pharmaceuticals, Inc., MRU Holdings, Inc., MSTI Holdings, Inc., Nestor... concerning the securities of MRU Holdings, Inc. because it has not filed any periodic reports since the...

  13. 78 FR 2481 - Watco Holdings, Inc., Watco Railroad Company Holdings, Inc., & Watco Acquisition Sub, Inc...

    Science.gov (United States)

    2013-01-11

    ... Acquisition Sub, Inc.--Acquisition of Control Exemption--Ann Arbor Railroad, Inc. Watco Holdings, Inc. (Watco Holdings), Watco Railroad Company Holdings, Inc. (Watco Railroad), and Watco Acquisition Sub, Inc. (Merger Sub), all noncarriers, have filed a verified notice of exemption under 49 CFR 1180.2(d)(2) for...

  14. 77 FR 48550 - Sears Holdings Management Corporation, A Division of Sears Holdings Corporation, Hoffman Estates...

    Science.gov (United States)

    2012-08-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Sears Holdings Management Corporation, A Division of Sears Holdings... workers at the Hoffman Estates, Illinois facility are similarly situated as the Sears Holdings workers...

  15. What does the future hold?

    Directory of Open Access Journals (Sweden)

    Fernando Peixoto Ferraz de Campos

    2012-03-01

    Full Text Available Since ancient times the knowledge of thehuman body and physiologic theories were obtainedsecretly, against the laws of the Catholic Church,through exhumation followed by anatomic dissectionof newly buried persons. From those times, theimportance of post-mortem study for the advance ofmedical knowledge was noted. In this context, thenineteenth century saw the heyday of the autopsy.Since then, autopsy has been responsible for theprogression of clinical medicine, medical education,epidemiology, and public health. From the 1950s upuntil 1990, 87 diseases were identified by autopsy.The discovery of severe acute respiratory syndrome(SARS epidemic in 2003 and the avian flu epidemicin 2006 were through autopsy as well.

  16. Collective behaviors of book holding durations

    Science.gov (United States)

    Li, Ren-De; Guo, Qiang; Han, Jing-Ti; Liu, Jian-Guo

    2016-10-01

    Duration can directly reflect the collective reading behaviors of library user book holding. In this paper, by introducing the burstiness and memory coefficients, we empirically investigate the collective book holding behavior of three university libraries. The statistical results show that there are similar properties among the students with different backgrounds, presenting the burstiness = - 0.2 and memory = 0.5 for three datasets, which indicates that memory and random effects coexist in student book holding durations. In addition, we analyze the behavior patterns without duplicate durations by merging a series of books borrowed and returned at the same time. The results show the average burstiness B increases to -0.16 and memory M drops to 0.16 for three datasets, which indicates that both duplicate behavior and student's preference affect the memory effect. Furthermore, we present a model which assumes student's next book holding duration follows the previous one with probability p, and with probability 1 - p, the student would hold the book independently. The experimental results show that the presented model can reproduce the burstiness and memory effect of student book holding durations when p = 0.5 for empirical datasets and p = 0.2 for de-duplicate datasets, which indicate that the student's preferential holding behavior occurs with the probability p. This work helps in deeply understanding the regularity of duration-based human behaviors.

  17. 42 CFR 495.366 - Financial oversight and monitoring of expenditures.

    Science.gov (United States)

    2010-10-01

    ... adoption of EHR technology, the Medicaid EHR incentive payments are paid on a voluntary basis and that... TECHNOLOGY INCENTIVE PROGRAM Requirements Specific to the Medicaid Program § 495.366 Financial oversight and... record technology to make payment. Subject to § 495.312, 495.314, and § 495.332, the State must...

  18. 76 FR 52997 - Public Company Accounting Oversight Board; Order Approving Proposed Board Funding Final Rules for...

    Science.gov (United States)

    2011-08-24

    ...\\ 15 U.S.C. 7217(b). \\2\\ 15 U.S.C. 78s(b)(1). \\3\\ Release No. 34-64816 (Jul. 6, 2011) [76 FR 40950 (Jul... COMMISSION Public Company Accounting Oversight Board; Order Approving Proposed Board Funding Final Rules for Allocation of the Board's Accounting Support Fee Among Issuers, Brokers, and Dealers, and Other Amendments...

  19. 75 FR 11210 - Public Company Accounting Oversight Board; Order Approving Proposed Amendment to Board Rules...

    Science.gov (United States)

    2010-03-10

    .... \\1\\ See SEC Release No. 34-61032 (November 19, 2009); 74 FR 61722 (November 25, 2009). II... required in those countries. See SEC Release No. 34-61212 (December 22, 2009); 74 FR 68875 (December 29... COMMISSION Public Company Accounting Oversight Board; Order Approving Proposed Amendment to Board...

  20. 75 FR 10507 - Information Security Oversight Office; National Industrial Security Program Policy Advisory...

    Science.gov (United States)

    2010-03-08

    ... RECORDS ADMINISTRATION Information Security Oversight Office; National Industrial Security Program Policy... regulation 41 CFR 101-6, announcement is made for a meeting of the National Industrial Security Program Policy Advisory Committee. The meeting will be held to discuss National Industrial Security Program...

  1. Management process invaded Ames as the Center shifted from NACA to NASA oversight. Ames constructed

    Science.gov (United States)

    1968-01-01

    Management process invaded Ames as the Center shifted from NACA to NASA oversight. Ames constructed a review room in its headquarters building where, in the graphical style that prevailed in the 1960's, Ames leadership could review progress against schedule, budget and performance measures. Shown, in October 1965 is Merrill Mead chief of Ames' program and resources office. (for H Julian Allen Retirement album)

  2. 32 CFR 2400.19 - Declassification by the Director of the Information Security Oversight Office.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Declassification by the Director of the Information Security Oversight Office. 2400.19 Section 2400.19 National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY...

  3. 34 CFR 1100.31 - Who is responsible for oversight of fellowship activities?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Who is responsible for oversight of fellowship activities? 1100.31 Section 1100.31 Education Regulations of the Offices of the Department of Education... services, to assume direct supervision of the fellowship activities. (b) Fellows may be assigned a...

  4. 48 CFR 936.609-3 - Work oversight in architect-engineer contracts.

    Science.gov (United States)

    2010-10-01

    ... architect-engineer contracts. 936.609-3 Section 936.609-3 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Architect-Engineer Services 936.609-3 Work oversight in architect-engineer contracts. In addition to the clause at...

  5. 48 CFR 36.609-3 - Work oversight in architect-engineer contracts.

    Science.gov (United States)

    2010-10-01

    ... architect-engineer contracts. 36.609-3 Section 36.609-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Architect-Engineer Services 36.609-3 Work oversight in architect-engineer contracts. The contracting...

  6. 75 FR 78779 - Order Approving Public Company Accounting Oversight Board Supplemental Budget Request To...

    Science.gov (United States)

    2010-12-16

    ... Release No. 63526/December 10, 2010] Order Approving Public Company Accounting Oversight Board Supplemental Budget Request To Establish an Office of Outreach and Small Business Liaison in 2010 The Sarbanes-Oxley Act of 2002 \\1\\ (the ``Sarbanes-Oxley Act'') established the Public Company Accounting...

  7. Commercial Multimodal Cargo Procedures in Dubai Were Generally Effective, but Contract Oversight Could Be Improved

    Science.gov (United States)

    2014-04-11

    performance measures. Specifically, USTRANSCOM contracting officials did not test the accuracy of the electronic data interchange ( EDI ) transactions to...having an official delegated contract oversight role. • test contractor-submitted EDI transactions used to verify contractor performance for the ITV...reports using EDI .8 The commercial multimodal contract quality assurance surveillance plan (QASP), states that contractor-provided EDI transactions are

  8. 20 CFR 411.595 - What oversight procedures are planned for the EN payment systems?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false What oversight procedures are planned for the EN payment systems? 411.595 Section 411.595 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE... procedures are planned for the EN payment systems? We use audits, reviews, studies and observation of...

  9. 78 FR 14801 - Veterinary Oversight of Antimicrobial Use in Livestock: Impact on Stakeholders; Public Meetings...

    Science.gov (United States)

    2013-03-07

    ... Resource Research Center, USDA Animal and Plant Health & Inspection Service, Veterinary Services, Centers... HUMAN SERVICES Food and Drug Administration Veterinary Oversight of Antimicrobial Use in Livestock... areas that may lack access to adequate veterinary services. The meetings are jointly sponsored by FDA...

  10. Patriot Modernization: Oversight Mechanism Needed to Track Progress and Provide Accountability

    Science.gov (United States)

    2016-08-01

    PATRIOT MODERNIZATION Oversight Mechanism Needed to Track Progress and Provide Accountability Report to...Congressional Committees August 2016 GAO-16-488 United States Government Accountability Office United States Government Accountability Office...Provide Accountability Why GAO Did This Study Patriot is a mobile Army surface-to-air missile system deployed worldwide to defend critical

  11. Bending strength and holding power of tibial locking screws.

    Science.gov (United States)

    Lin, J; Lin, S J; Chiang, H; Hou, S M

    2001-04-01

    The bending strength and holding power of two types of specially designed tibial locking devices, a both-ends-threaded screw and an unthreaded bolt, were studied and compared with four types of commercially available tibial interlocking screws: Synthes, Howmedica, Richards, and Osteo AG. To test bending strength, the devices were inserted into a high molecular weight polyethylene tube and loaded at their midpoint by a materials testing machine to simulate a three point bending test. Single loading yielding strength and cyclic loading fatigue life were measured. To test holding power, the devices were inserted into tubes made of polyurethane foam, and their tips were loaded axially to measure pushout strength. The devices were tested with two different densities of foam materials and two different sizes of pilot holes. Insertion torque and stripping torque of the screws were measured first. Pushout tests were performed with each screw inserted with a tightness equal to 60% of its stripping torque. Test results showed that the yielding strength and the fatigue life were related closely to the inner diameter of the screws. The stripping torque predicted the pushout strength more reliably than did the insertion torque. All tested devices showed greater holding power in the foam with the higher density and with the smaller pilot holes. The both-ends-threaded screw had the highest pushout strength and a satisfactory fatigue strength. The unthreaded bolt had the highest fatigue strength but only fair holding power. Clinical studies of the use of these two types of locking devices are worthwhile.

  12. Study Finds Ebola Treatment ZMapp Holds Promise, Although Results Not Definitive

    Science.gov (United States)

    ... News Release Thursday, October 13, 2016 Study finds Ebola treatment ZMapp holds promise, although results not definitive ... emergency. A clinical trial to evaluate the experimental Ebola treatment ZMapp found it to be safe and ...

  13. Bilateral trade, openness and asset holdings

    OpenAIRE

    Peter, Alexandra

    2010-01-01

    This paper analyzes the relationship between bilateral trade flows, trade openness, and asset holdings in a three-country stochastic general equilibrium model. The threecountry model set-up enables me to disentangle and separate the effects bilateral trade flows and trade openness have on bilateral portfolio patterns. I find that both factors independently influence bilateral asset holdings. Higher bilateral trade as well as higher trade openness lead to a higher bilateral foreign asset posit...

  14. Report: EPA Region 9 Needs to Improve Oversight Over Commonwealth of the Northern Mariana Islands Consolidated Cooperative Agreements

    Science.gov (United States)

    Report #16-P-0207, June 20, 2016. More than $58 million in consolidated cooperative agreement funds is not being administered efficiently and effectively due to inadequate oversight and a lack of internal controls.

  15. NASA S and MA at the Crossroads; The Role of NASA Quality Insight/Oversight for Commercial Crewed Launch Vehicles

    Science.gov (United States)

    Malone, Roy W., Jr.

    2010-01-01

    The presentation slides examine: The Journey, Current Safety and Mission Assurance (S and MA) Oversight/Insight, The Change, The Issue, Potential NASA relationship with Commercial Partners, and Commercial "X" FRR - Are you Go.

  16. Hospital Board Oversight of Quality and Patient Safety: A Narrative Review and Synthesis of Recent Empirical Research

    National Research Council Canada - National Science Library

    ROSS MILLAR; RUSSELL MANNION; TIM FREEMAN; HUW T.O. DAVIES

    2013-01-01

    .... National directives and initiatives emphasize the importance of action by boards, but the empirical basis for informing effective hospital board oversight has yet to receive full and careful review. Methods...

  17. EOQ Models with Varying Holding Cost

    Directory of Open Access Journals (Sweden)

    Naser Ghasemi

    2013-01-01

    Full Text Available Models of inventory management contain different parameters. An issue is observable in the classical models which can be related to the determination of the quantity of the economic order and the quantity of the economic production. In these models, the parameters like setup and holding costs and also the rate of demands are fixed. This matter causes the quantity of the economic ordering in classic model to have some differences in comparison with the real-world conditions. It should be stated that holding cost of spoiled and useless products is not always fixed and so the costs increase by passing the time. This paper is an attempt to develop classical EOQ models by considering holding cost as an increasing function of the ordering cycle length. So the classical EOQ models are developed, and the related optimum quantity to the ordering cycle length, economic ordering quantity, and the optimum total cost are determined.

  18. Decompression sickness following breath-hold diving.

    Science.gov (United States)

    Schipke, J D; Gams, E; Kallweit, Oliver

    2006-01-01

    Despite convincing evidence of a relationship between breath-hold diving and decompression sickness (DCS), the causal connection is only slowly being accepted. Only the more recent textbooks have acknowledged the risks of repetitive breath-hold diving. We compare four groups of breath-hold divers: (1) Japanese and Korean amas and other divers from the Pacific area, (2) instructors at naval training facilities, (3) spear fishers, and (4) free-dive athletes. While the number of amas is likely decreasing, and Scandinavian Navy training facilities recorded only a few accidents, the number of spear fishers suffering accidents is on the rise, in particular during championships or using scooters. Finally, national and international associations (e.g., International Association of Free Drives [IAFD] or Association Internationale pour Le Developpment De L'Apnee [AIDA]) promote free-diving championships including deep diving categories such as constant weight, variable weight, and no limit. A number of free-diving athletes, training for or participating in competitions, are increasingly accident prone as the world record is presently set at a depth of 171 m. This review presents data found after searching Medline and ISI Web of Science and using appropriate Internet search engines (e.g., Google). We report some 90 cases in which DCS occurred after repetitive breath-hold dives. Even today, the risk of suffering from DCS after repetitive breath-hold diving is often not acknowledged. We strongly suggest that breath-hold divers and their advisors and physicians be made aware of the possibility of DCS and of the appropriate therapeutic measures to be taken when DCS is suspected. Because the risk of suffering from DCS increases depending on depth, bottom time, rate of ascent, and duration of surface intervals, some approaches to assess the risks are presented. Regrettably, none of these approaches is widely accepted. We propose therefore the development of easily manageable

  19. Military Personnel: Additional Steps Are Needed to Strengthen DOD’s Oversight of Ethics and Professionalism Issues

    Science.gov (United States)

    2015-09-01

    Business Conduct, Waltham, Massachusetts Lockheed Martin Corporation Office of Ethics and Business Conduct EthicsOne, Inc. Executive Leadership, Boston...MILITARY PERSONNEL Additional Steps Are Needed to Strengthen DOD’s Oversight of Ethics and Professionalism Issues...DATES COVERED 00-00-2015 to 00-00-2015 4. TITLE AND SUBTITLE Military Personnel: Additional Steps Are Needed to Strengthen DOD’s Oversight of Ethics

  20. The Department of Defense and Veteran Affairs Health Care Joint Venture at Tripler Army Medical Center Needs More Management Oversight

    Science.gov (United States)

    2013-09-18

    E M B E R 1 8 , 2 0 1 3 The Department of Defense and Veteran Affairs Health Care Joint Venture at Tripler Army Medical Center Needs More...Department of Defense and Veteran Affairs Health Care Joint Venture at Tripler Army Medical Center Needs More Management Oversight 5a. CONTRACT NUMBER...Health Care Joint Venture at Tripler Army Medical Center Needs More Management Oversight Objective Our audit objective was to determine whether the

  1. Peer-reviewed forensic consultation in practice: multidisciplinary oversight in common expertise.

    Science.gov (United States)

    Welner, Michael; Davey, Emily E; Bernstein, Adam

    2014-09-01

    The fallibility of forensic science consultation is an ongoing and major justice concern. Prospective peer-reviewed forensic consultation has over 10 years of application in American criminal and civil courts, adapting from the traditional oversight of teaching hospitals, rules of evidence and discovery, conventions of testimony of expert witnesses, and attorneys' overall trial strategy. In systematizing heightened oversight, this process ensures greater accountability in forensic science consultation. The integration of peer reviewers' complementary expertise and experience enhances the sophistication and overall quality of assessment. Forensic examination frequently involves the interface of different specialties. Multidisciplinary peer review augments expert proficiency with that of professional peers having different vantage points from relevant scientific disciplines. This approach ensures greater sophistication of a case inquiry, built-in accountability, and streamlined processes when multiple experts are necessitated. Here, the authors present examples of several cases and the primary and secondary benefits of this collaborative, rigorous, cross-disciplinary exercise.

  2. Mobile health applications: the patchwork of legal and liability issues suggests strategies to improve oversight.

    Science.gov (United States)

    Yang, Y Tony; Silverman, Ross D

    2014-02-01

    Mobile health (mHealth) technology has facilitated the transition of care beyond the traditional hospital setting to the homes of patients. Yet few studies have evaluated the legal implications of the expansion of mHealth applications, or "apps." Such apps are affected by a patchwork of policies related to medical licensure, privacy and security protection, and malpractice liability. For example, the privacy protections of the Health Insurance Portability and Accountability Act (HIPAA) of 1996 may apply to only some uses of the apps. Similarly, it is not clear what a doctor's malpractice liability would be if he or she injured a patient as the result of inaccurate information supplied by the patient's self-monitoring health app. This article examines the legal issues related to the oversight of health apps, discusses current federal regulations, and suggests strategies to improve the oversight of these apps.

  3. Governance and oversight of researcher access to electronic health data: the role of the Independent Scientific Advisory Committee for MHRA database research, 2006-2015.

    Science.gov (United States)

    Waller, P; Cassell, J A; Saunders, M H; Stevens, R

    2017-03-01

    In order to promote understanding of UK governance and assurance relating to electronic health records research, we present and discuss the role of the Independent Scientific Advisory Committee (ISAC) for MHRA database research in evaluating protocols proposing the use of the Clinical Practice Research Datalink. We describe the development of the Committee's activities between 2006 and 2015, alongside growth in data linkage and wider national electronic health records programmes, including the application and assessment processes, and our approach to undertaking this work. Our model can provide independence, challenge and support to data providers such as the Clinical Practice Research Datalink database which has been used for well over 1,000 medical research projects. ISAC's role in scientific oversight ensures feasible and scientifically acceptable plans are in place, while having both lay and professional membership addresses governance issues in order to protect the integrity of the database and ensure that public confidence is maintained.

  4. Hospital board oversight of quality and safety: a stakeholder analysis exploring the role of trust and intelligence.

    Science.gov (United States)

    Millar, Ross; Freeman, Tim; Mannion, Russell

    2015-06-16

    Hospital boards, those executive members charged with developing appropriate organisational strategies and cultures, have an important role to play in safeguarding the care provided by their organisation. However, recent concerns have been raised over boards' ability to enact their duty to ensure the quality and safety of care. This paper offers critical reflection on the relationship between hospital board oversight and patient safety. In doing so it highlights new perspectives and suggestions for developing this area of study. The article draws on 10 interviews with key informants and policy actors who form part of the 'issue network' interested in the promotion of patient safety in the English National Health Service. The interviews surfaced a series of narratives regarding hospital board oversight of patient safety. These elaborated on the role of trust and intelligence in highlighting the potential dangers and limitations of approaches to hospital board oversight which have been narrowly focused on a risk-based view of organisational performance. In response, a need to engage with the development of trust based organisational relationships is identified, in which effective board oversight is built on 'trust' characterised by styles of leadership and behaviours that are attentive to the needs and concerns of both staff and patients. Effective board oversight also requires the gathering and triangulating of 'intelligence' generated from both national and local information sources. We call for a re-imagination of hospital board oversight in the light of these different perspectives and articulate an emerging research agenda in this area.

  5. A survey of front-line paramedics examining the professional relationship between paramedics and physician medical oversight.

    Science.gov (United States)

    Foerster, Christopher R; Tavares, Walter; Virkkunen, Ilkka; Kämäräinen, Antti

    2017-06-07

    Paramedicine is often dependent on physician medical directors and their associated programs for direction and oversight. A positive relationship between paramedics and their oversight physicians promotes safety and quality care while a strained or ineffective one may threaten these goals. The objective of this study was to explore and understand the professional relationship between paramedics and physician medical oversight as viewed by front-line paramedics. All active front-line paramedics from four municipal paramedic services involving three medical oversight groups in Ontario were invited to complete an online survey. Five hundred and four paramedics were invited to participate in the study, with 242 completing the survey (48% response rate); 66% male, 76% primary care paramedics with an average of 13 (SD=9) years of experience. Paramedics had neutral or positive perceptions regarding their autonomy, opportunities to interact with their medical director, and medical director understanding of the prehospital setting. Paramedics perceived medical directives as rigid and ambiguous. A significant amount of respondents reported a perception of having provided suboptimal patient care due to fear of legal or disciplinary consequences. Issues of a lack of support for critical thinking and a lack of trust between paramedics and medical oversight groups were often raised. Paramedic perceptions of physician medical oversight were mixed. Concerning areas identified were perceptions of ambiguous written directives and concerns related to the level of trust and support for critical thinking. These perceptions may have implications for the system of care and should be explored further.

  6. Delinquent Medical Service Accounts at Naval Medical Center Portsmouth Need Additional Management Oversight

    Science.gov (United States)

    2015-03-04

    H 4 , 2 0 1 5 Delinquent Medical Service Accounts at Naval Medical Center Portsmouth Need Additional Management Oversight Report No. DODIG-2015...04 MAR 2015 2. REPORT TYPE 3. DATES COVERED 00-00-2015 to 00-00-2015 4. TITLE AND SUBTITLE Delinquent Medical Service Accounts at Naval...of Defense that supports the warfighter; promotes accountability , integrity, and efficiency; advises the Secretary of Defense and Congress; and

  7. Ideal Police Oversight and Review: The Next Piece of the Community Policing Puzzle

    Science.gov (United States)

    2015-12-01

    ceiling for budgets was set at $1.5 million, twice the initial criterion, allowing six boards to be researched further. Thus, boards from Oakland...Common Sense about Police Review, 260. 80 “Office of Civil Rights and Wage Enforcement / Civilian Review Board / Civilian Board FAQs,” City of...Civil Rights and Wage Enforcement,” City of Baltimore. 85 Hunt, request for information response. 29 activities of the oversight entity, they

  8. The effect of friction in the hold down post spherical bearings on hold down post loads

    Science.gov (United States)

    Richardson, James A.

    1990-01-01

    The effect of friction at the connection of the Solid Rocket Booster (SRB) aft skirt and the mobile launch platform (MLP) hold down posts was analyzed. A simplified model of the shuttle response during the Space Shuttle Main Engine (SSME) buildup was constructed. The model included the effect of stick-slip friction for the rotation of the skirt about the spherical bearing. Current finite element models assume the joint is completely frictionless in rotation and therefore no moment is transferred between the skirt and the hold down posts. The model was partially verified against test data and preliminary parameter studies were performed. The parameter studies indicated that the coefficient of friction strongly influenced the moment on the hold down posts. The coefficient of friction had little effect on hold down post vertical loads, however. Further calibration of the model is necessary before the effect of friction on the hold down post horizontal loads can be analyzed.

  9. Holding children in mind or holding therapy: developing an ethical position.

    Science.gov (United States)

    Simmonds, John

    2007-04-01

    Attachment theory and therapy have established themselves as major constructs in foster care and adoption practice. The depth of the explanatory power of attachment theory and research have done much to both identify the source of developmental difficulties in adopted and fostered children, and of the significant changes that can be made when these children are placed with 'autonomously' classified carers. However, the power of the concept has also led to a proliferation of ideas, particularly therapeutic models that can, in some cases, stray a long way from the core of what is effective, safe and ethical clinical practice. Holding therapy is one of these models. The British Association for Adoption and Fostering developed a position statement on this practice, setting it within a broader framework of assessment and intervention. But like the model, the development of the position statement became controversial in its development. The article charts some of the critical issues and identifies the very significant dilemmas for parents and carers caught up in the maelstrom of challenging behaviours and disturbing feelings. The conclusion turns to one of the key components of an attachment-based idea: The critical importance of finding the space to think and to feel what the child is communicating without resorting to dangerous retaliation.

  10. Towards a classification of weak hand holds

    NARCIS (Netherlands)

    Kimmelman, V.; Sáfár, A.; Crasborn, O.

    2016-01-01

    The two symmetrical manual articulators (the hands) in signed languages are a striking modalityspecific phonetic property. The weak hand can maintain the end position of an articulation while the other articulator continues to produce additional signs. This weak hand spreading (hold) has been

  11. Holding Kids Accountable: Shaming with Compassion.

    Science.gov (United States)

    Campbell, H. Allen; Revering, Andrew C.

    1997-01-01

    Describes the philosophy and procedures of Police Accountability Conferencing, a restorative justice approach in which police and school authorities, victims, offenders, and families are brought together in a process designed to hold youth accountable for their actions. Details the program's potential for reclaiming youth who have engaged in…

  12. Should we Hold the Obese Responsible?

    DEFF Research Database (Denmark)

    Nielsen, Morten Ebbe Juul; Andersen, Martin Marchman

    2014-01-01

    holding the obese responsible will have positive consequences. Taking these two conceptions of responsibility into account, the authors turn their analysis toward examining the relevant moral considerations to be taken into account when public policies regarding obesity rely on such a conception...

  13. 12 CFR 1732.7 - Record hold.

    Science.gov (United States)

    2010-01-01

    ... retention program of an Enterprise shall: (1) Address how employees and, as appropriate, how agents or... AND SOUNDNESS RECORD RETENTION Record Retention Program § 1732.7 Record hold. (a) Definition. For... permissible destruction of records; and, (3) Provide that any employee and, as appropriate, any agent or...

  14. How Much Popcorn Will Our Classroom Hold?

    Science.gov (United States)

    Rommel-Esham, Katie

    2007-01-01

    "How much popcorn will our classroom hold?" This intriguing question sparked a terrific integrated science and math exploration that the author conducted with fifth-and sixth-grade students. In the process of finding the classroom's volume, students developed science-process skills (e.g., developing a plan, measurement, collecting and interpreting…

  15. Empowerment Amongst Teachers Holding Leadership Positions

    Science.gov (United States)

    Avidov-Ungar, Orit; Friedman, Izhak; Olshtain, Elite

    2014-01-01

    This study used semi-structured in-depth interviews to explore empowerment patterns among teachers who hold leadership positions in school. Our qualitative analysis presents a hierarchical ladder with three types of empowerment amongst these teachers, ranging from limited empowerment through rewarding empowerment to change-enhancing empowerment.…

  16. Uncertainty Quantification for Cargo Hold Fires

    CERN Document Server

    DeGennaro, Anthony M; Martinelli, Luigi; Rowley, Clarence W

    2015-01-01

    The purpose of this study is twofold -- first, to introduce the application of high-order discontinuous Galerkin methods to buoyancy-driven cargo hold fire simulations, second, to explore statistical variation in the fluid dynamics of a cargo hold fire given parameterized uncertainty in the fire source location and temperature. Cargo hold fires represent a class of problems that require highly-accurate computational methods to simulate faithfully. Hence, we use an in-house discontinuous Galerkin code to treat these flows. Cargo hold fires also exhibit a large amount of uncertainty with respect to the boundary conditions. Thus, the second aim of this paper is to quantify the resulting uncertainty in the flow, using tools from the uncertainty quantification community to ensure that our efforts require a minimal number of simulations. We expect that the results of this study will provide statistical insight into the effects of fire location and temperature on cargo fires, and also assist in the optimization of f...

  17. 12 CFR 583.20 - Savings and loan holding company.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Savings and loan holding company. 583.20... REGULATIONS AFFECTING SAVINGS AND LOAN HOLDING COMPANIES § 583.20 Savings and loan holding company. The term savings and loan holding company means any company that directly or indirectly controls a...

  18. 12 CFR 583.4 - Bank holding company.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Bank holding company. 583.4 Section 583.4 Banks... AFFECTING SAVINGS AND LOAN HOLDING COMPANIES § 583.4 Bank holding company. The term bank holding company means any company which has control over any bank or over any company that is or becomes a bank...

  19. Living on Hold in Palliative Cancer Care

    Directory of Open Access Journals (Sweden)

    Anna Sandgren, RN, M.Sc.N., Ph.D. Student

    2010-02-01

    Full Text Available The aim of this study was to develop a classic grounded theory of palliative cancer patients and their relatives in the context of home care. We analyzed interviews and data related to the behaviour of both patients and relatives. “Living on hold” emerged as the pattern of behaviour through which the patients and relatives deal with their main concern, being put on hold. Living on Hold involves three modes: Fighting, Adjusting and Surrendering. Mode being may change during a trajectory depending on many different factors. There are also different triggers that can start a reconciling process leading to a change of mode. This means that patients and relatives can either be in the same mode or in different modes simultaneously. More or less synchronous modes may lead to problems and conflicts within the family, or with the health professionals.

  20. Electrochemical cell with electrode hold-down

    Energy Technology Data Exchange (ETDEWEB)

    Boudrot, R.J.; Shambaugh, J.S.; Zeltzer, H.

    1981-06-30

    A primary electrochemical cell including a hold-down unit for securing and preventing movement of a physically large battery stack of the cell is disclosed. The battery stack is disposed within a rectangular metal housing of the cell, together with an electrolytic solution, and comprises a large number of rectangular anodes and cathode structures arranged in the battery stack in alternation. The hold-down unit is disposed in the cell in abutment with the top of the battery stack and an inner surface of a cover assembly secured to the housing. The hold-down unit includes a pair of opposed end sections in abutment with the interior surfaces of one pair of walls of the housing and lying orthogonally to the planes of the components of the battery stack, and a pair of opposed connecting sections in abutment with the interior surfaces of the other pair of walls of the housing and interconnecting the pair of end sections. The connecting sections are spaced from the battery stack and define, together with the end sections, top and side openings. These openings, together with large openings in the end sections, minimize the displacement of electrolytic solution in the region of the cell above the battery stack. The connecting sections further include insulated, resilient, angularly-oriented tabs capable of deflection by contact with the top cover assembly for compensating for variations in tolerances associated with the manufacture and assembly of the components of the cell.

  1. 12 CFR 584.2-2 - Permissible bank holding company activities of savings and loan holding companies.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Permissible bank holding company activities of savings and loan holding companies. 584.2-2 Section 584.2-2 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY SAVINGS AND LOAN HOLDING COMPANIES § 584.2-2 Permissible bank holding...

  2. Institutional Oversight of the Graduate Medical Education Enterprise: Development of an Annual Institutional Review

    Science.gov (United States)

    Amedee, Ronald G.; Piazza, Janice C.

    2016-01-01

    Background: The Accreditation Council for Graduate Medical Education (ACGME) fully implemented all aspects of the Next Accreditation System (NAS) on July 1, 2014. In lieu of periodic accreditation site visits of programs and institutions, the NAS requires active, ongoing oversight by the sponsoring institutions (SIs) to maintain accreditation readiness and program quality. Methods: The Ochsner Health System Graduate Medical Education Committee (GMEC) has instituted a process that provides a structured, process-driven improvement approach at the program level, using a Program Evaluation Committee to review key performance data and construct an annual program evaluation for each accredited residency. The Ochsner GMEC evaluates the aggregate program data and creates an Annual Institutional Review (AIR) document that provides direction and focus for ongoing program improvement. This descriptive article reviews the 2014 process and various metrics collected and analyzed to demonstrate the program review and institutional oversight provided by the Ochsner graduate medical education (GME) enterprise. Results: The 2014 AIR provided an overview of performance and quality of the Ochsner GME program for the 2013-2014 academic year with particular attention to program outcomes; resident supervision, responsibilities, evaluation, and compliance with duty‐hour standards; results of the ACGME survey of residents and core faculty; and resident participation in patient safety and quality activities and curriculum. The GMEC identified other relevant institutional performance indicators that are incorporated into the AIR and reflect SI engagement in and contribution to program performance at the individual program and institutional levels. Conclusion: The Ochsner GME office and its program directors are faced with the ever-increasing challenges of today's healthcare environment as well as escalating institutional and program accreditation requirements. The overall commitment of

  3. EXPERT PANEL OVERSIGHT COMMITTEE ASSESSMENT OF FY2008 CORROSION AND STRESS CORROSION CRACKING SIMULANT TESTING PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    BOOMER KD

    2009-01-08

    The Expert Panel Oversight Committee (EPOC) has been overseeing the implementation of selected parts of Recommendation III of the final report, Expert Panel workshop for Hanford Site Double-Shell Tank Waste Chemistry Optimization, RPP-RPT-22126. Recommendation III provided four specific requirements necessary for Panel approval of a proposal to revise the chemistry control limits for the Double-Shell Tanks (DSTs). One of the more significant requirements was successful performance of an accelerated stress corrosion cracking (SCC) experimental program. This testing program has evaluated the optimization of the chemistry controls to prevent corrosion in the interstitial liquid and supernatant regions of the DSTs.

  4. Tennessee Oversight Agreement annual report, May 31, 1994--June 30, 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    The Tennessee Department of Environment and Conservation`s DOE Oversight Division (TDEC/DOE-O) is responsible for assuring the citizens of Tennessee that their health, safety and environment on the Oak Ridge Reservation are protected and that appropriate remedial action is taken to provide this protection. TDEC/DOE-O has five program sections that reflect the organizational structure of the TDEC Bureau of Environment Divisions, as well as DOE`s Environmental Safety and Health, Waste Management, and Environmental Restoration Programs.

  5. WTO oversight over bilateral agreements: from a notification to an examination process?

    DEFF Research Database (Denmark)

    Mortensen, Jens Ladefoged

    2014-01-01

    The TTIP will – like other free trade agreements (FTAs) – violate one of the cornerstones of the WTO, i.e. the Most-Favoured-Nation (MFN) principle. However, the multilateral trading system has since 1947 permitted the formation of trading blocks and preferential bilateral trading partnerships....... This contribution asks how the WTO can fulfill its task of ensuring that FTAs do not systematically undermine the multilateral trading order. It focuses on the issue of transparency in the current oversight process and discusses whether the WTO secretariat should be granted a stronger mandate to proactively...

  6. Research on Cross Border AuditOversight between China and the U.S.

    Institute of Scientific and Technical Information of China (English)

    陈瀚爵

    2014-01-01

    Companies have gone worldwide and are listed on capital markets in dif erent continents. Their auditors have fol owed them. To al ow for an ef ective global audit oversight in order to protect the investors, international co-operation is required. The disparity in laws of audit supervision and conflicts between China and the United States inflict financial damage on investors. By analyzing rudimentary reasons behind this issue and the progress both parties have done, the author then il ustrates international cooperation among other regions to make the prediction and recommendations in dealing with such conflicts.

  7. Are Economists More Likely to Hold Stocks?

    DEFF Research Database (Denmark)

    Christiansen, Charlotte; Joensen, Eyðfrið Juanna Schrøter; Rangvid, Jesper

    education, even when controlling for several background characteristics. We make use of a large register-based panel data set containing detailed information on the educational attainments and various financial and socioeconomic variables.We model the stock market participation decision by the probit model......A unique data set enables us to test the hypothesis that due to informational advantages economists are more likely to hold stocks than otherwise identical investors. Weconfirm that economists have a significantly higher probability of participating in the stockmarket than investors with any other...

  8. Should we Hold the Obese Responsible?

    DEFF Research Database (Denmark)

    Nielsen, Morten Ebbe Juul; Andersen, Martin Marchman

    2014-01-01

    conceptualizations of responsibility: backward-looking and forward-looking conceptualizations. When ascertaining responsibility in a backward-looking sense, one has to determine how that state of affairs came into being or where the agent stood in relation to it. In contrast, a forward-looking conceptualization...... holding the obese responsible will have positive consequences. Taking these two conceptions of responsibility into account, the authors turn their analysis toward examining the relevant moral considerations to be taken into account when public policies regarding obesity rely on such a conception...

  9. A transparent oversight policy for human anatomical specimen management: the University of California, Davis experience.

    Science.gov (United States)

    Schmitt, Brandi; Wacker, Charlotte; Ikemoto, Lisa; Meyers, Frederick J; Pomeroy, Claire

    2014-03-01

    The authors describe the development and implementation of a University of California (UC) system of oversight, education, tracking, and accountability for human anatomical specimen use in education and research activities. This program was created and initially implemented at UC Davis in 2005. Several incidents arising out of the handling of human anatomical specimens at UC campuses revealed significant challenges in the system for maintaining control of human anatomical specimens used in education and research. These events combined to undermine the public perception for research and educational endeavors involving anatomical materials at public institutions. Risks associated with the acquisition, maintenance, and disposal of these specimens were not fully understood by the faculty, staff, and students who used them. Laws governing sources of specimens are grouped with those that govern organ procurement and tissue banking, and sometimes are found in cemetery and funeral regulations. These variables complicate interpretations and may hinder compliance. To regain confidence in the system, the need to set appropriate and realistic guidelines that mitigate risk and facilitate an institution's research and educational mission was identified. This article chronicles a multiyear process in which diverse stakeholders developed (1) a regulatory policy for oversight, (2) a policy education program, (3) procedures for tracking and accountability, and (4) a reporting and enforcement mechanism for appropriate and ethical use of human anatomical specimens in university education and research.

  10. Nanotechnology, voluntary oversight, and corporate social performance: does company size matter?

    Science.gov (United States)

    Kuzma, Jennifer; Kuzhabekova, Aliya

    2011-04-01

    In this article, we examine voluntary oversight programs for nanotechnology in the context of corporate social performance (CSP) in order to better understand the drivers, barriers, and forms of company participation in such programs. At the theoretical level, we use the management framework of CSP to understand the voluntary behavior of companies. At the empirical level, we investigate nanotech industry participation in the Environmental Protection Agency's Nanoscale Materials Stewardship Program (NMSP) as an example of CSP, in order to examine the effects of company characteristics on CSP outcomes. The analysis demonstrates that, on the average, older and larger companies for which nanotech is one of the many business activities demonstrate greater CSP as judged by company actions, declarations, and self-evaluations. Such companies tended to submit more of the requested information to the NMSP, including specific information about health and safety, and to claim fewer of the submitted items as confidential business information. They were also more likely to have on-line statements of generic and nano-specific corporate social responsibility principles, policies, and achievements. The article suggests a need to encourage smaller and younger companies to participate in voluntary oversight programs for nanotechnology and presents options for better design of these programs.

  11. Interweaving Curriculum Committees: A New Structure to Facilitate Oversight and Sustain Innovation.

    Science.gov (United States)

    Stoddard, Hugh A; Brownfield, Erica D; Churchward, Gordon; Eley, J William

    2016-01-01

    Undergraduate medical education curricula have increased in complexity over the past 25 years; however, the structures for administrative oversight of those curricula remain static. Although expectations for central oversight of medical school curricula have increased, individual academic departments often expect to exert control over the faculty and courses that are supported by the department. The structure of a governance committee in any organization can aid or inhibit that organization's functioning. In 2013, following a major curriculum change in 2007, the Emory University School of Medicine (EUSOM) implemented an "interwoven" configuration for its curriculum committee to better oversee the integrated curriculum. The new curriculum committee structure involves a small executive committee and 10 subcommittees. Each subcommittee performs a specific task or oversees one element of the curriculum. Members, including students, are appointed to two subcommittees in a way that each subcommittee is composed of representatives from multiple other subcommittees. This interweaving facilitates communication between subcommittees and also encourages members to become experts in specific tasks while retaining a comprehensive perspective on student outcomes. EUSOM's previous structure of a single committee with members representing individual departments did not promote cohesive management. The interwoven structure aligns neatly with the goals of the integrated curriculum. Since the restructuring, subcommittee members have been engaged in discussions and decisions on many key issues and expressed satisfaction with the format. The new structure corresponds to EUSOM's educational goals, although the long-term impact on student outcomes still needs to be assessed.

  12. Establishing an Ambulatory Medicine Quality and Safety Oversight Structure: Leveraging the Fractal Model.

    Science.gov (United States)

    Kravet, Steven J; Bailey, Jennifer; Demski, Renee; Pronovost, Peter

    2016-07-01

    Academic health systems face challenges in the governance and oversight of quality and safety efforts across their organizations. Ambulatory practices, which are growing in number, size, and complexity, face particular challenges in these areas. In February 2014, leaders at Johns Hopkins Medicine (JHM) implemented a governance, oversight, and accountability structure for quality and safety efforts across JHM ambulatory practices. This model was based on the fractal approach, which balances independence and interdependence and provides horizontal and vertical support. It set expectations of accountability at all levels from the Board of Trustees to frontline staff and featured a cascading structure that reached all units and ambulatory practices. This model leveraged an Ambulatory Quality Council led by a physician and nurse dyad to provide the infrastructure to share best practices, continuously improve, and define accountable local leaders. This model was incorporated into the quality and safety infrastructure across JHM. Improved outcomes in the domains of patient safety/risk reduction, externally reported quality measures, patient care/experience, and value have been demonstrated. An additional benefit was an improvement in Medicaid value-based purchasing metrics, which are linked to several million dollars of revenue. As this model matures, it will serve as a mechanism to align quality standards and programs across regional, national, and international partners and to provide a clear quality structure as new practices join the health system. Future efforts will link this model to JHM's academic mission, enhancing education to address Accreditation Council for Graduate Medical Education core competencies.

  13. Automated Inventory Control System for Nigeria Power Holding

    African Journals Online (AJOL)

    PROF. O. E. OSUAGWU

    2013-09-01

    Sep 1, 2013 ... Power Holding Company of Nigeria (PHCN) currently holds in excess of millions in spare parts inventory between ... Heightened operational risks, lower availability and ... expectations, demand uncertainty, and the flexibility of ...

  14. 26 CFR 1.563-2 - Personal holding company tax.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Personal holding company tax. 1.563-2 Section 1... (CONTINUED) INCOME TAXES (CONTINUED) Deduction for Dividends Paid § 1.563-2 Personal holding company tax. In the case of a personal holding company subject to the provisions of section 541, dividends paid...

  15. 42 CFR 412.344 - Hold-harmless payment methodology.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Hold-harmless payment methodology. 412.344 Section...-Related Costs § 412.344 Hold-harmless payment methodology. (a) General. A hospital paid under the hold-harmless payment methodology receives a payment per discharge based on the higher of: (1) 85 percent of...

  16. Creditor rights, country governance, and corporate cash holdings

    NARCIS (Netherlands)

    Seifert, Bruce; Gonenc, Halit

    2016-01-01

    This study examines the impact of creditor rights and country governance on cash holdings using a sample of firms from 47 countries. We hypothesize that cash holdings are smaller when both creditor rights and country governance are high. In these circumstances firms will not need to hold as much cas

  17. A mathematical model of aerosol holding chambers

    DEFF Research Database (Denmark)

    Zak, M; Madsen, J; Berg, E

    1999-01-01

    A mathematical model of aerosol delivery from holding chambers (spacers) was developed incorporating tidal volume (VT), chamber volume (Vch), apparatus dead space (VD), effect of valve insufficiency and other leaks, loss of aerosol by immediate impact on the chamber wall, and fallout of aerosol...... in the chamber with time. Four different spacers were connected via filters to a mechanical lung model, and aerosol delivery during "breathing" was determined from drug recovery from the filters. The formula correctly predicted the delivery of budesonide aerosol from the AeroChamber (Trudell Medical, London......, Ontario, Canada), NebuChamber (Astra, Södirtälje, Sweden) and Nebuhaler (Astra) adapted for babies. The dose of fluticasone proportionate delivered by the Babyhaler (Glaxco Wellcome, Oxbridge, Middlesex, UK) was 80% of that predicted, probably because of incomplete priming of this spacer. Of the above...

  18. Risk of Neurological Insult in Competitive Deep Breath-Hold Diving.

    Science.gov (United States)

    Tetzlaff, Kay; Schöppenthau, Holger; Schipke, Jochen D

    2017-02-01

    It has been widely believed that tissue nitrogen uptake from the lungs during breath-hold diving would be insufficient to cause decompression stress in humans. With competitive free diving, however, diving depths have been ever increasing over the past decades. A case is presented of a competitive free-diving athlete who suffered stroke-like symptoms after surfacing from his last dive of a series of 3 deep breath-hold dives. A literature and Web search was performed to screen for similar cases of subjects with serious neurological symptoms after deep breath-hold dives. A previously healthy 31-y-old athlete experienced right-sided motor weakness and difficulty speaking immediately after surfacing from a breathhold dive to a depth of 100 m. He had performed 2 preceding breath-hold dives to that depth with surface intervals of only 15 min. The presentation of symptoms and neuroimaging findings supported a clinical diagnosis of stroke. Three more cases of neurological insults were retrieved by literature and Web search; in all cases the athletes presented with stroke-like symptoms after single breath-hold dives of depths exceeding 100 m. Two of these cases only had a short delay to recompression treatment and completely recovered from the insult. This report highlights the possibility of neurological insult, eg, stroke, due to cerebral arterial gas embolism as a consequence of decompression stress after deep breath-hold dives. Thus, stroke as a clinical presentation of cerebral arterial gas embolism should be considered another risk of extreme breath-hold diving.

  19. IV Iron: To Give or to Hold in the Presence of Infection in Adults Undergoing Hemodialysis.

    Science.gov (United States)

    Hain, Debra; Braun, Mauro

    2015-01-01

    Intravenous (IV) iron is often given to treat iron deficiency anemia in adults undergoing hemodialysis. Evidence supports an association between IV iron and infection exits, which often create a clinical dilemma: whether to give or to hold in the presence of infection. This article presents the best available evidence regarding the risk of IV iron and infection along with nephrology nursing practice implications.

  20. 76 FR 40950 - Public Company Accounting Oversight Board; Notice of Filing of Proposed Board Funding Final Rules...

    Science.gov (United States)

    2011-07-12

    ... COMMISSION Public Company Accounting Oversight Board; Notice of Filing of Proposed Board Funding Final Rules for Allocation of the Board's Accounting Support Fee Among Issuers, Brokers, and Dealers, and Other... 2002 (the ``Act''), notice is hereby given that on June 21, 2011, the Public Company...

  1. 78 FR 12369 - United States Government Policy for Institutional Oversight of Life Sciences Dual Use Research of...

    Science.gov (United States)

    2013-02-22

    ... Public comments are sought on the entirety of the proposed United States Government Policy for... TECHNOLOGY POLICY United States Government Policy for Institutional Oversight of Life Sciences Dual Use... responsible conduct and communication of such research. The proposed Policy herein, United States...

  2. 78 FR 39021 - Privacy Act of 1974; Privacy and Civil Liberties Oversight Board; System of Records Notice

    Science.gov (United States)

    2013-06-28

    ... Request Files''. DATES: Written comments should be submitted on or before July 29, 2013. This new system... proposed creation of a system of records for FOIA and Privacy Act case files. SYSTEM OF RECORDS PCLOB--1, Freedom of Information Act and Privacy Act Files. SYSTEM NAME: Privacy and Civil Liberties Oversight...

  3. The World Bank Inspection Panel and Quasi-Judicial Oversight: In Search of the 'Judicial Spirit' in Public International Law

    NARCIS (Netherlands)

    A. Naudé Fourie (Andria)

    2009-01-01

    textabstractThis PhD dissertation conceptualizes the World Bank Inspection Panel as a mechanism of quasi-judicial review or oversight, aimed at enhancing the accountability and legitimacy of the World Bank – which is conceived as an international institution exercising public power. The author engag

  4. 20 CFR 645.245 - Who is responsible for oversight and monitoring of Welfare-to-Work grants?

    Science.gov (United States)

    2010-04-01

    ... monitoring of Welfare-to-Work grants? 645.245 Section 645.245 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR PROVISIONS GOVERNING WELFARE-TO-WORK GRANTS General Program and Administrative Requirements § 645.245 Who is responsible for oversight and monitoring of Welfare-to-Work...

  5. Better Planning and Oversight Could Have Reduced Construction Delays and Costs at the Kabul Military Training Center

    Science.gov (United States)

    2011-10-26

    Representative CSTC-A Combined Security Transition Command - Afghanistan DNC Discrepancy and Non-Compliance DPW Department of Public Works ECC ECC...Discrepancy and Non-Compliance ( DNC ) log, stating that SIGAR Audit-12-2 Contractor Performance and Oversight / Kabul Military Training Center Page 15

  6. Mental models students hold of zoos

    Science.gov (United States)

    Patrick, Patricia Gail

    The purpose of this study was to depict the mental models high school students, ages 14-18, hold of zoos. This study also examined how students define conservation and the role of zoos in conservation. This study examined the differences in mental models of 84 students (1) 21 students who had visited a zoo with their teacher in the same semester in which the study was conducted, (2) 21 students who had visited a zoo during another school year with their teacher, (3) 21 students who had visited the zoo without a teacher, and (4) 21 students who had never visited a zoo. It also examined the mental models of students of different ethnicities and examined differences in mental models of young men and women. This study was conducted and the data analyzed using a qualitative methodology research design. All 84 students completed a demographic questionnaire, a concept map, and a ranking concepts exercise. Twenty-four students were interviewed. The findings indicated that: (1) students who had visited a zoo have a richer mental model of zoos than students who have never visited a zoo, (2) students who had visited a zoo with their teacher provided a deeper richer understanding of the roles of zoos in conservation and education, (3) students who have never visited a zoo do have mental models of zoos, (4) students do not mention conservation with respect to zoos unless specifically asked about the role of zoos in conservation, and (5) students did not mention the zoo's connection to species survival nor did they view zoos as a source of information for conservation-related topics. The data indicated that the mental models student hold of zoos consist of seven themes: (1) organisms, (2) people, (3) amenities, (4) descriptive terms, (5) habitats, (6) education, and (7) conservation. The seven themes were defined and used to create the Zoo Acuity Model. The central constructs of the Zoo Acuity Model are the Observation Framework, the Interaction Framework, and the Information

  7. Unfinished business: ongoing ethical exceptionalism in the oversight of human pluripotent stem cell research in Canada.

    Science.gov (United States)

    Baylis, Françoise; Downie, Jocelyn

    2012-01-01

    In this article, we critically examine the arguments for and against the exceptional status given human pluripotent stem cell research in Canada (through the latest [December 2010] revision of the Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans), and conclude that this exceptionalism is unwarranted and ethically unsound. In our view, the three federal research granting agencies should honor their longstanding commitment that researchers, research sponsors, and Research Ethics Boards in Canada have access to "a single reference document for all research involving humans conducted under the auspices of institutions eligible for Agency funding." As well, responsibility for the development, interpretation, and implementation of Canada's research ethics guidelines should be under the authority of a single oversight body that is independent of the federal research granting Agencies.

  8. Governmental oversight of prescribing medications: history of the US Food and Drug Administration and prescriptive authority.

    Science.gov (United States)

    Plank, Linda S

    2011-01-01

    The evolution of drug regulation and awarding of prescriptive authority is a complex and sometimes convoluted process that can be confusing for health care providers. A review of the history of how drugs have been manufactured and dispensed helps explain why this process has been so laborious and complicated. Because the federal and state governments have the responsibility for protecting the public, most regulations have been passed with the intentions of ensuring consumer safety. The current system of laws and regulations is the result of many years of using the legal system to correct drug marketing that had adverse health consequences. Government oversight will continue as prescribing medications transitions to an electronic form and as health care professionals in addition to physicians seek to gain prescriptive authority.

  9. When do tissues and cells become products? Regulatory oversight of emerging biological therapies.

    Science.gov (United States)

    Farrugia, Albert

    2006-01-01

    Although therapeutics derived from biological sources have been subjected to regulatory oversight for some time, the products used in transplantation procedures have historically been exempt from this oversight. These products have been viewed as being part of medical practice rather than as the result of mainstream pharmaceutical manufacture. Furthermore, their unique source makes them difficult to assess in traditional regulatory systems based on the tenets of pharmaceutical quality control. With the increasing use of transplantation therapies to both replace dysfunctional organs and to influence genetic and metabolic processes, public health concerns on these therapies have increased. In addition, it is recognized that therapeutic claims for some of these interventions need to be properly assessed. These considerations have led the established regulatory agencies of the developed world to develop new regulatory paradigms for the products of transplantation practice. While a number of concerns have driven these developments, the minimization of infectious disease risk remains the paramount driver for introducing these regulatory systems. More than the regulation of medicines and medical devices manufactured in traditional pharmaceutical modes, the regulation of cell and tissue products is intimately linked to areas of public health policy and funding. This places regulators in a challenging position as they attempt to reconcile their roles as independent assessors with the needs of the overall public health framework. This is particularly difficult when considering measures which may affect access to life saving therapies. Regulators have recognized the need to assess these therapies through systems which incorporate consideration of risk-benefit ratios and include mechanisms for transparent and accountable release of products when full compliance to traditional concepts of manufacturing practice is not possible.

  10. Tennessee Oversight Agreement annual report, May 13, 1993--May 12, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-09-01

    This report discusses the activities of the Division of DOE Oversight in the areas of coordination with other State Agencies with regard to environmental restoration, corrective action, and waste management activities on the Oak Ridge Reservation; and the Division`s efforts to keep the public informed of those DOE activities that may impact their health and the environment. This report includes the status of the Division`s efforts in implementing the Tennessee Oversight Agreement (TOA). Each Program Section provides information concerning the status of its activities. The Administrative Section has been instrumental in achieving access to the ORR without prior notification to DOE and in obtaining documents and environmental, waste management, safety, and health information in a timely manner. The Environmental Restoration Program has provided in-depth document reviews and on-site coordination and monitoring of field activities required under the Federal Facility Agreement. Most notable of the activities are the investigations and planned remediation of the Lower East Fork Poplar Creek and the Watts Bar Reservoir. The Waste Management Program has audited DOE`s compliance with air, water, solid, hazardous, and mixed waste storage, treatment, and disposal regulations. Effort was focused on all three DOE Facilities on the ORR. The final portion of this report discusses the Division`s findings and recommendations. Most significant of these issues is the Division`s request to be an active participant in DOE`s prioritization of its TOA commitments. Other issues discussed include long term storage of radioactive waste and the use of environmental restoration funds. A discussion of those findings and recommendations provided in last year`s annual report and addressed by DOE are included in this report as well. All documents, logs, files, etc. supporting this report are available for review during routine business hours at the Division`s office.

  11. Human Rights and the Regulation of Transnational Clinical Trials

    NARCIS (Netherlands)

    Pierik, R.

    2015-01-01

    One of the more worrying trends in globalization today is the growing practice of western companies relocating clinical trials to impoverished countries. This paper starts by providing a comprehensive description of the practice and its current regulatory oversight. It argues that this regulatory

  12. Intangible Capital and Corporate Cash Holdings: Theory and Evidence

    OpenAIRE

    Dalida Kadyrzhanova; Antonio Falato; Jae Sim

    2012-01-01

    The rise in intangible capital is a fundamental driver of the secular trend in US corporate cash holdings over the last decades. We construct a new measure of intangible capital and show that intangible capital is the most important firm-level determinant of corporate cash holdings. Our measure accounts for almost as much of the secular increase in cash since the 1980s as all other standard determinants together. We then develop a new model of corporate cash holdings that introduces intangibl...

  13. Multiple Job Holding, Local Labor Markets, and the Business Cycle

    OpenAIRE

    Hirsch, Barry T.; Husain, Muhammad M.; Winters, John V

    2016-01-01

    About 5 percent of U.S. workers hold multiple jobs, which can exacerbate or mitigate employment changes over the business cycle. Theory is ambiguous and prior literature is not fully conclusive. We examine the relationship between multiple job holding and local unemployment rates using a large Current Population Survey data set of workers in urban labor markets during 1998-2013. High unemployment labor markets have moderately lower rates of multiple job holding. Yet no relationship between mu...

  14. Sports-related lung injury during breath-hold diving

    Directory of Open Access Journals (Sweden)

    Tanja Mijacika

    2016-12-01

    Full Text Available The number of people practising recreational breath-hold diving is constantly growing, thereby increasing the need for knowledge of the acute and chronic effects such a sport could have on the health of participants. Breath-hold diving is potentially dangerous, mainly because of associated extreme environmental factors such as increased hydrostatic pressure, hypoxia, hypercapnia, hypothermia and strenuous exercise. In this article we focus on the effects of breath-hold diving on pulmonary function. Respiratory symptoms have been reported in almost 25% of breath-hold divers after repetitive diving sessions. Acutely, repetitive breath-hold diving may result in increased transpulmonary capillary pressure, leading to noncardiogenic oedema and/or alveolar haemorrhage. Furthermore, during a breath-hold dive, the chest and lungs are compressed by the increasing pressure of water. Rapid changes in lung air volume during descent or ascent can result in a lung injury known as pulmonary barotrauma. Factors that may influence individual susceptibility to breath-hold diving-induced lung injury range from underlying pulmonary or cardiac dysfunction to genetic predisposition. According to the available data, breath-holding does not result in chronic lung injury. However, studies of large populations of breath-hold divers are necessary to firmly exclude long-term lung damage.

  15. Sports-related lung injury during breath-hold diving.

    Science.gov (United States)

    Mijacika, Tanja; Dujic, Zeljko

    2016-12-01

    The number of people practising recreational breath-hold diving is constantly growing, thereby increasing the need for knowledge of the acute and chronic effects such a sport could have on the health of participants. Breath-hold diving is potentially dangerous, mainly because of associated extreme environmental factors such as increased hydrostatic pressure, hypoxia, hypercapnia, hypothermia and strenuous exercise.In this article we focus on the effects of breath-hold diving on pulmonary function. Respiratory symptoms have been reported in almost 25% of breath-hold divers after repetitive diving sessions. Acutely, repetitive breath-hold diving may result in increased transpulmonary capillary pressure, leading to noncardiogenic oedema and/or alveolar haemorrhage. Furthermore, during a breath-hold dive, the chest and lungs are compressed by the increasing pressure of water. Rapid changes in lung air volume during descent or ascent can result in a lung injury known as pulmonary barotrauma. Factors that may influence individual susceptibility to breath-hold diving-induced lung injury range from underlying pulmonary or cardiac dysfunction to genetic predisposition.According to the available data, breath-holding does not result in chronic lung injury. However, studies of large populations of breath-hold divers are necessary to firmly exclude long-term lung damage.

  16. Biosimilar DMARDs: What Does the Future Hold?

    Science.gov (United States)

    Araújo, Filipe; Gonçalves, João; Fonseca, João Eurico

    2016-04-01

    Biological medicinal products, albeit fundamental in unresponsive inflammatory rheumatic diseases, represent a significant economic burden to healthcare systems worldwide. A new landmark in the treatment of these conditions was achieved with the European Medicines Agency's endorsement of CT-P13, the first biosimilar of a monoclonal antibody, infliximab. The main driving force behind biosimilar development is to improve accessibility at lower costs, provided the quality, efficacy and safety of the biosimilar is similar to that of the reference drug. Many other biosimilar candidates are currently under development and will probably be approved in the near future, posing complex prescribing decisions for rheumatologists. In this article, biosimilar disease-modifying anti-rheumatic drugs (DMARDs) are put into perspective: what they are, the stepwise manufacturing process and the available mechanisms that regulate the thorough comparability exercise. Non-clinical and clinical data leading to CT-P13 approval are briefly reviewed, and current clinical data on upcoming biosimilars are also addressed. Other matters covered include extrapolation of clinical indications, interchangeability and automatic substitution. As cumulative evidence on the use of biosimilars grows, controversies abate and patients and physicians become reassured. However, adequate answers to the uncertainties still surrounding biosimilar agents are necessary to ensure the trust of rheumatologists and, on a larger scale, to guarantee their widespread use and success.

  17. 12 CFR 575.14 - Subsidiary holding companies.

    Science.gov (United States)

    2010-01-01

    ... the approval of its shareholders, except as otherwise provided in this section 5 or to the extent that... proposed by the board of directors of the MHC subsidiary holding company, approved by the shareholders by a... to subsidiary holding companies. (3) Optional charter provision limiting minority stock ownership....

  18. Er det etisk acceptabelt at holde elefanter i zoologiske haver?

    DEFF Research Database (Denmark)

    Sandøe, Peter

    2016-01-01

    Bag diskussionen om flytning af 17 vilde elefanter fra Afrika til amerikanske zoolgiske haver ligger en dybere uenighed om berettigelsen af at holde elefanter i fangenskab,......Bag diskussionen om flytning af 17 vilde elefanter fra Afrika til amerikanske zoolgiske haver ligger en dybere uenighed om berettigelsen af at holde elefanter i fangenskab,...

  19. Evaluation of Manometric Measures during Tongue-Hold Swallows

    Science.gov (United States)

    Doeltgen, Sebastian H.; Witte, Ulrike; Gumbley, Freya; Huckabee, Maggie-Lee

    2009-01-01

    Purpose: Based on visual inspection, prior research documented increased movement of the posterior pharyngeal wall in healthy volunteers during tongue-hold swallows. This manometric study investigated the immediate effects of the tongue-hold maneuver on pharyngeal peak pressure generation, duration of pressure generation, and pressure slope…

  20. Acute effects of cannabis on breath-holding duration.

    Science.gov (United States)

    Farris, Samantha G; Metrik, Jane

    2016-08-01

    Distress intolerance (an individual's perceived or actual inability to tolerate distressing psychological or physiological states) is associated with cannabis use. It is unknown whether a biobehavioral index of distress intolerance, breath-holding duration, is acutely influenced (increased or decreased) by cannabis. Such information may further inform understanding of the expression of psychological or physiological distress postcannabis use. This within-subjects study examined whether smoked marijuana with 2.7%-3.0% delta-9-tetrahydrocannabinol (THC), relative to placebo, acutely changed duration of breath holding. Participants (n = 88; 65.9% male) were nontreatment-seeking frequent cannabis users who smoked placebo or active THC cigarette on two separate study days and completed a breath-holding task postsmoking. Controlling for baseline breath-holding duration and participant sex, THC produced significantly shorter breath-holding durations relative to placebo. There was a significant interaction of drug administration × frequency of cannabis use, such that THC decreased breath-holding time among less frequent but not among more frequent users. Findings indicate that cannabis may exacerbate distress intolerance (via shorter breath-holding durations). As compared to less frequent cannabis users, frequent users display tolerance to cannabis' acute effects including increased ability to tolerate respiratory distress when holding breath. Objective measures of distress intolerance are sensitive to contextual factors such as acute drug intoxication, and may inform the link between cannabis use and the expression of psychological distress. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  1. Forord, midtersider og efterord i Hold Ud Bro

    DEFF Research Database (Denmark)

    2016-01-01

    at skrive så nu sidder jeg bare her og surmuler så hold ud bro hold ud hold ud bro hold ud Grønthandleren, 19 år Vi sidder i et kælderlokale i skolen på Ringe Statsfængsel. Vi er syv mennesker, alle i gang med en skriveøvelse. I fem minutter skriver vi løs. Ingen siger noget, tastaturer klaprer...... Grønthandleren læser sin tekst højt, griner vi. Det er sjovt, fordi nogen af os ikke fatter, hvad en kartoffel (en hvid dansker) er. Så taler vi om uretfærdighed. Til sidst taler vi om slutningen, ”hold ud bro”. I teksten er det noget, forfatteren siger til sig selv: ”Så nu er jeg træt af at skrive så nu sidder...... jeg bare her og surmuler så hold ud bro hold ud.” Teksterne i ‘Hold ud bro’ er skrevet af tre unge indsatte i et skriveværksted, der fandt sted i Ringe Statsfængsel. Det foregik over tre dage i starten af marts 2016. Vi var tre unge indsatte, en lærer og tre skrivementorer. Vi arbejde primært med...

  2. 17 CFR 450.4 - Custodial holdings of government securities.

    Science.gov (United States)

    2010-04-01

    ... government securities. 450.4 Section 450.4 Commodity and Securities Exchanges DEPARTMENT OF THE TREASURY REGULATIONS UNDER TITLE II OF THE GOVERNMENT SECURITIES ACT OF 1986 CUSTODIAL HOLDINGS OF GOVERNMENT SECURITIES BY DEPOSITORY INSTITUTIONS § 450.4 Custodial holdings of government securities....

  3. Korean Investment in EU through Holding Companies: A Case Study

    Directory of Open Access Journals (Sweden)

    Seong-Bong Lee

    1998-09-01

    Full Text Available When transnational enterprises set subsidiary companies in certain area, their major aim is to invest indirectly through the holding companies which hold invested share. Especially, because of the geographical neighborhood and economic integration, investing by holding companies is common in Europe. In Europe, taking full advantage of holding company is out of the following two reasons. Firstly, the efficiency and flexibility of the manage strategy of a group could be elevated by making full use of the holding company. Secondly, the transnational enterprises have the possibility of flexible management at the tax strategy level. Recently, the Korean companies are making the best use of holding companies when they are Marching into the EU. In the year 1996, group K purchased 8 enterprises of a certain industry section of B, a German company, setting holding companies in Germany. The analysis result of the case shows that the manage efficiency could be risen and the taxation could be reduced by way of making use of holding companies. As to the Korean investment efficiency of overseas indirect investment in EU, this thesis brought forward a blueprint about integrating the local companies.

  4. Course holding by cyclists and moped riders. (Revised version).

    NARCIS (Netherlands)

    Godhelp, J. & Wouters, P.I.J.

    1980-01-01

    Course holding by cyclists and moped riders includes both steering alongside a course and stabilising the vehicle. Inability to hold course may lead to conflicts with other road users. To design safe bicycle and moped facilities and to consider the safety of those existing, knowledge about performan

  5. Residual magnetism holds solenoid armature in desired position

    Science.gov (United States)

    Crawford, R. P.

    1967-01-01

    Holding solenoid uses residual magnetism to hold its armature in a desired position after excitation current is removed from the coil. Although no electrical power or mechanical devices are used, the solenoid has a low tolerance to armature displacement from the equilibrium position.

  6. Er det etisk acceptabelt at holde elefanter i zoologiske haver?

    DEFF Research Database (Denmark)

    Sandøe, Peter

    2016-01-01

    Bag diskussionen om flytning af 17 vilde elefanter fra Afrika til amerikanske zoolgiske haver ligger en dybere uenighed om berettigelsen af at holde elefanter i fangenskab,......Bag diskussionen om flytning af 17 vilde elefanter fra Afrika til amerikanske zoolgiske haver ligger en dybere uenighed om berettigelsen af at holde elefanter i fangenskab,...

  7. Hospital board oversight of quality and patient safety: a narrative review and synthesis of recent empirical research.

    Science.gov (United States)

    Millar, Ross; Mannion, Russell; Freeman, Tim; Davies, Huw T O

    2013-12-01

    Recurring problems with patient safety have led to a growing interest in helping hospitals' governing bodies provide more effective oversight of the quality and safety of their services. National directives and initiatives emphasize the importance of action by boards, but the empirical basis for informing effective hospital board oversight has yet to receive full and careful review. This article presents a narrative review of empirical research to inform the debate about hospital boards' oversight of quality and patient safety. A systematic and comprehensive search identified 122 papers for detailed review. Much of the empirical work appeared in the last ten years, is from the United States, and employs cross-sectional survey methods. Recent empirical studies linking board composition and processes with patient outcomes have found clear differences between high- and low-performing hospitals, highlighting the importance of strong and committed leadership that prioritizes quality and safety and sets clear and measurable goals for improvement. Effective oversight is also associated with well-informed and skilled board members. External factors (such as regulatory regimes and the publication of performance data) might also have a role in influencing boards, but detailed empirical work on these is scant. Health policy debates recognize the important role of hospital boards in overseeing patient quality and safety, and a growing body of empirical research has sought to elucidate that role. This review finds a number of areas of guidance that have some empirical support, but it also exposes the relatively inchoate nature of the field. Greater theoretical and methodological development is required if we are to secure more evidence-informed governance systems and practices that can contribute to safer care. © 2013 Milbank Memorial Fund.

  8. The Parent Control in the Mechanical Engineering Management-Holding

    Science.gov (United States)

    Šnircová, Jana; Hodulíková, Petra; Joehnk, Peter

    2012-12-01

    The group of entities under the control of parent, so called holding, is arisen as the result and the most often used form of the business concentration nowadays. The paper is focused to find special tasks of parent company for to preserve effective unified economic control in the management-holding. The unified economic control the holding exists in the conditions of the main conflict of interest - holding is not a legal but economic unit and the connected companies into it have a legal autonomy with the economic dependence. The unified economic control limits the financial independence of every individual company of the holding. The attention in the paper is concentrated to the management concept of the parent control, i.e. the parent company supervises the control of intragroup flows and all of subsidiaries production activities.

  9. 1992 Annual performance report for Environmental Monitoring and Oversight at Department of Energy facilities in New Mexico

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-31

    In October 1990 an Agreement-in-Principle (AIP) was entered into between the US Department of Energy (DOE) and the State of New Mexico for the purpose of supporting State oversight activities at DOE facilities in New Mexico. The State`s lead agency for the Agreement is the New Mexico Environment Department (NMED). DOE has agreed to provide the State with resources over a five year period to support State activities in environmental oversight, monitoring, access and emergency response to ensure compliance with applicable federal, state, and local laws at Los Alamos National Laboratory (LANL), Sandia National Laboratories (SNL), the Waste Isolation Pilot Plant (WIPP), and the Inhalation Toxicology Research Institute (ITRI). The Agreement is designed to assure the citizens of New Mexico that public health, safety and the environment are being protected through existing programs; DOE is in compliance with applicable laws and regulations; DOE has made substantial new commitments; cleanup and compliance activities have been prioritized; and a vigorous program of independent monitoring and oversight by the State is underway. This report relates the quality and effectiveness of the facilities` environmental monitoring and surveillance programs. This report satisfies that requirement for the January--December 1992 time frame.

  10. Comparison of Management Oversight and Risk Tree and Tripod-Beta in Excavation Accident Analysis

    Directory of Open Access Journals (Sweden)

    Mohamadfam

    2015-01-01

    Full Text Available Background Accident investigation programs are a necessary part in identification of risks and management of the business process. Objectives One of the most important features of such programs is the analysis technique for identifying the root causes of accidents in order to prevent their recurrences. Analytical Hierarchy Process (AHP was used to compare management oversight and risk tree (MORT with Tripod-Beta in order to determine the superior technique for analysis of fatal excavation accidents in construction industries. Materials and Methods MORT and Tripod-Beta techniques were used for analyzing two major accidents with three main steps. First, these techniques were applied to find out the causal factors of the accidents. Second, a number of criteria were developed for the comparison of the techniques and third, using AHP, the techniques were prioritized in terms of the criteria for choosing the superior one. Results The Tripod-Beta investigation showed 41 preconditions and 81 latent causes involved in the accidents. Additionally, 27 root causes of accidents were identified by the MORT analysis. Analytical hierarchy process (AHP investigation revealed that MORT had higher priorities only in two criteria than Tripod-Beta. Conclusions Our findings indicate that Tripod-Beta with a total priority of 0.664 is superior to MORT with the total priority of 0.33. It is recommended for future research to compare the available accident analysis techniques based on proper criteria to select the best for accident analysis.

  11. Addressing conflicts of interest in nanotechnology oversight: lessons learned from drug and pesticide safety testing

    Science.gov (United States)

    Elliott, Kevin C.; Volz, David C.

    2012-01-01

    Financial conflicts of interest raise significant challenges for those working to develop an effective, transparent, and trustworthy oversight system for assessing and managing the potential human health and ecological hazards of nanotechnology. A recent paper in this journal by Ramachandran et al., J Nanopart Res, 13:1345-1371 (2011) proposed a two-pronged approach for addressing conflicts of interest: (1) developing standardized protocols and procedures to guide safety testing; and (2) vetting safety data under a coordinating agency. Based on past experiences with standardized test guidelines developed by the international Organization for Economic Cooperation and Development (OECD) and implemented by national regulatory agencies such as the U.S. Environmental Protection Agency (EPA) and Food and Drug Administration (FDA), we argue that this approach still runs the risk of allowing conflicts of interest to influence toxicity tests, and it has the potential to commit regulatory agencies to outdated procedures. We suggest an alternative approach that further distances the design and interpretation of safety studies from those funding the research. In case the two-pronged approach is regarded as a more politically feasible solution, we also suggest three lessons for implementing this strategy in a more dynamic and effective manner.

  12. MiR-21 expression in the tumor cell compartment holds unfavorable prognostic value in gliomas

    DEFF Research Database (Denmark)

    Hermansen, Simon Kjær; Dahlrot, Rikke Hedegaard; Nielsen, Boye Schnack

    2013-01-01

    miR-21 was associated with poor prognosis when adjusting for known clinical parameters (age, grade, and sex) in a multivariate analysis [p = 0.049, hazard ratio (HR) = 1.545, 95 % CI, 1.002-2.381]. In conclusion, we have shown that miR-21 is located in both tumor cells and tumor blood vessels...... and that its level in the tumor cell compartment holds unfavorable prognostic value in gliomas....

  13. Optimization of single shot 3D breath-hold non-enhanced MR angiography of the renal arteries

    Directory of Open Access Journals (Sweden)

    Tan Huan

    2012-05-01

    Full Text Available Abstract Background Cardiac and navigator-gated, inversion-prepared non-enhanced magnetic resonance angiography techniques can accurately depict the renal arteries without the need for contrast administration. However, the scan time and effectiveness of navigator-gated techniques depend on the subject respiratory pattern, which at times results in excessively prolonged scan times or suboptimal image quality. A single-shot 3D magnetization-prepared steady-state free precession technique was implemented to allow the full extent of the renal arteries to be depicted within a single breath-hold. Methods Technical optimization of the breath-hold technique was performed with fourteen healthy volunteers. An alternative magnetization preparation scheme was tested to maximize inflow signal. Quantitative and qualitative comparisons were made between the breath-hold technique and the clinically accepted navigator-gated technique in both volunteers and patients on a 1.5 T scanner. Results The breath-hold technique provided an average of seven fold reduction in imaging time, without significant loss of image quality. Comparable single-to-noise and contrast-to-noise ratios of intra- and extra-renal arteries were found between the breath-hold and the navigator-gated techniques in volunteers. Furthermore, the breath-hold technique demonstrated good image quality for diagnostic purposes in a small number of patients in a pilot study. Conclusions The single-shot, breath-hold technique offers an alternative to navigator-gated methods for non-enhanced renal magnetic resonance angiography. The initial results suggest a potential supplementary clinical role for the breath-hold technique in the evaluation of suspected renal artery diseases.

  14. Bus coordination holding control for transit hubs under APTS

    Institute of Scientific and Technical Information of China (English)

    TENG Jing; ZHAO Ming

    2009-01-01

    To increase the passenger transferring efficiency, the bus coordination holding control for transit hubs,hich is as an important dynamic dispatching method for improving the service level of transit hubs, was studied in the framework of bus coordination dispatching mode. Firstly, the bus coordination holding control flow was studied based on Advanced Public Transportation Systems (APTS) environment. Then a control model was presented to optimize the bus vehicle holding time, and a genetic algorithm was designed as the solving method. In the end, an example was given to illustrate the effectiveness of the control strategy and the algorithm.

  15. Effects of Piracetam on Pediatric Breath Holding Spells: A Randomized Double Blind Controlled Trial

    Directory of Open Access Journals (Sweden)

    Ali ABBASKHANIAN

    2013-01-01

    Full Text Available How to cite this article:Abbaskhanian A, Ehteshami S, Sajjadi S, Rezai MS. Effects of Piracetam on Pediatric Breath Holding Spells: A Randomized Double Blind Controlled Trial. Iran J Child Neurol Autumn 2012; 6(4: 9-15. Abstarct:Objective Breath holding spells (BHS are common paroxysmal non-epileptic eventsin the pediatric population which are very stressfull despite their harmlessnature. There has been no specific treatment found for the spells yet. The aimof this study was to evaluate the efficacy of piracetam (2-oxo-l-pyrrolidineon these children.Materials & MethodsIn this randomized double blind clinical trial study, 150 children with severe BHS referred to our pediatric outpatient service were enrolled from August2011 to July 2012. The patients were randomized into two equal groups.One received 40mg/kg/day piracetam and the other group received placebo,twice daily. Patients were followed monthly for three months. The numberof attacks/month before and after treatment were documented.ResultsOf the enrolled patients, 86 were boys. The mean age of the patients was17 months (range, 6 to 24 months. In the piracetam group, 1 month after treatment an 81% response to treatment was found. In the placebo group,none of the patients had complete remission and 7% of the cases had partialremission. Overall, control of breath-holding spells was observed in 91%of the patients in the group taking piracetam as compared with 16% in the group taking placebo at the end of the study. There wasd nosignificant difference detected between the groups regarding the prevalenceof drug side effects.ConclusionA significant difference was detected between piracetam and placebo in prevention and controlling BHS. Piracetam (40mg/kg/day had a good effecton our patients. ReferencesDi Mario FJ Jr. Prospective study of children with cyanotic and pallid breath-holding spells. Pediatrics. 2001 Feb;107(2:265-9.Kotagal P, Costa M, Wyllie E, Wolgamuth B. Paroxysmal non epileptic

  16. Assessment of heart rate variability in breath holding children by 24 hour Holter monitoring.

    Science.gov (United States)

    Yilmaz, Osman; Ciftel, Murat; Ozturk, Kezban; Kilic, Omer; Kahveci, Hasan; Laloğlu, Fuat; Ceylan, Ozben

    2015-02-01

    Previous studies have shown that the underlying pathophysiologic mechanism in children with breath holding may be generalised autonomic dysregulation. Thus, we performed cardiac rhythm and heart rate variability analyses using 24-hour Holter monitoring to evaluate the cardiac effects of autonomic dysregulation in children with breath-holding spells. We performed cardiac rhythm and heart rate analyses using 24-hour Holter monitors to evaluate the cardiac effects of autonomic dysregulation in children during a breath-holding spell. Our study group consisted of 68 children with breath-holding spells - 56 cyanotic type and 12 pallid type - and 39 healthy controls. Clinical and heart rate variability results were compared between each spell type - cyanotic or pallid - and the control group; significant differences (p50 ms, and square root of the mean of the sum of squares of the differences between adjacent NN intervals values were found between the pallid and cyanotic groups. Holter monitoring for 24 hours and heart rate variability parameters, particularly in children with pallid spells, are crucial for evaluation of cardiac rhythm changes.

  17. 分娩球运动待产结合自主式屏气法在促进自然分娩中的临床应用%Clinical application of childbirth ball movement predelivery combined with autonomous breath holding method in promo-ting natural childbirth

    Institute of Scientific and Technical Information of China (English)

    陈叔容; 刘静梅; 任玉平; 李艳; 邓富秋

    2015-01-01

    目的:探讨分娩球运动待产与自主式屏气法联合对促进自然分娩的效果分析。方法选取200例初产妇作为研究对象,将其随机分为研究组与对照组,每组各100例。研究组产妇第一产程应用分娩球运动待产,第二产程应用自主式屏气法分娩。对照组产妇第一产程应用传统方式分娩,第二产程应用自主式屏气法分娩。结果研究组和对照组的自然分娩率分别为90.0%、72.0%,差异有统计学意义(P<0.05)。研究组和对照组的满意度分别为92.0%、73.0%,两组差异有统计学意义(P<0.05)。研究组第一产程时间、第二产程时间、屏气用力时长、产后2 h 出血量明显低于对照组,研究组先露下降速度明显高于对照组,差异均有统计学意义(P<0.05)。结论应用分娩球运动待产与自主式屏气法联合可以促进自然分娩,提高自然分娩率,缩短产程时间,提高产妇的护理满意度。%Objective To investigate the effect of childbirth ball movement predelivery combined with autono‐mous breath holding method in promoting natural childbirth .Methods 200 primiparae were selected as the research subjects and randomly divided into the study group and the control group ,100 cases in each group .The study group applied the childbirth ball movement for conducting predelivery during the first stage of labor and the autonomous breath holding method for delivery during the second stage of labor .The control group applied the conventional mode for delivery during the first stage of labor and the autonomous breath holding method for delivery during the second stage of labor .Results The natural birth rate was 90 .0% in the study group and 72 .0% in the control group ,the difference was statistically significant(P< 0 .05) .The satisfaction degree was 92 .0% in the study group and 73 .0%in the control group ,the difference was statistically significant

  18. Stem Cells Hold Promise, Peril in Treating Seniors' Eye Disease

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_164099.html Stem Cells Hold Promise, Peril in Treating Seniors' Eye Disease ... 15, 2017 WEDNESDAY, March 15, 2017 (HealthDay News) -- Stem cells may offer new hope for people losing their ...

  19. Hearing Loss Rates Holding Steady for U.S. Teens

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_167456.html Hearing Loss Rates Holding Steady for U.S. Teens: Study Vaccine ... via earphones than ever before, but rates of hearing loss have not increased. Still, "the overall take-home ...

  20. Ways for Romanian Holding Refreshment – a Point of View

    Directory of Open Access Journals (Sweden)

    Andrea Feher

    2010-10-01

    Full Text Available The current situation of the most Romanian holdings does not allow the performance of a high-quality and competitive agricultural production on the internal market and on the external market as well and the provision of a decent standard of living for farmers. The overtaking of this situation supposes the conversion of the country-like family holdings into modern trading family holdings, able to induce technological progress and to valorise the natural, labour and material resources available in our country. The activity content for the formation of such holdings is represented by the enhancement of their economic capacity and of their competitional power, in concordance with the requirements of future agriculture and of Romania’s integration in the EU structures. The accomplishment of such an objective implies actions and measures of agricultural policy, correlated to each other and sustainable, which should combine the private economic interest with the national one.

  1. Hold That Pose: Yoga May Ease Tough Depression

    Science.gov (United States)

    ... html Hold That Pose: Yoga May Ease Tough Depression Study finds weekly sessions, plus deep breathing, helped ... the doctor ordered when it comes to beating depression, new research suggests. Researchers found that weekly sessions ...

  2. Researchers Put Embryo Development 'On Hold' in Mice

    Science.gov (United States)

    ... medlineplus.gov/news/fullstory_162187.html Researchers Put Embryo Development 'On Hold' in Mice Putting stem cells ... were able to halt development of early mouse embryos for up to a month in the lab ...

  3. Southeast Region Headboat Survey-Compliance tracking holds list

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The holds list is used to track vessel compliance by recording any missing/late trip reports. This list is shared with enforcement officers in the event that legal...

  4. ENERGY STAR Certified Commercial Hot Food Holding Cabinet

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 2.0 ENERGY STAR Program Requirements for Commercial Hot Food Holding Cabinets that are...

  5. Orthodontic retention to have and to hold.

    Science.gov (United States)

    Kalha, Anmol S

    2016-12-01

    Data sourcesCochrane Oral Health Group's Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, US National Institutes of Health Trials Registry and The World Health Organization (WHO) Clinical Trials Registry Platform, abstracts from the British Orthodontic Conference, the European Orthodontic Conference and the International Association for Dental Research (IADR) from 2011 to 2015 and the bibliographies of identified studies.Study selectionRandomised controlled trials (RCTs) involving children and adults who had had retainers fitted or adjunctive procedures undertaken to prevent relapse following orthodontic treatment with braces were considered.Data extraction and synthesisTwo reviewers independently selected studies, abstracted data and assessed study quality. For continuous data mean differences (MD) with 95% confidence intervals (CI) were calculated with ratios (RR) and 95% CI for dichotomous outcomes.ResultsFifteen studies involving a total of 1722 patients were included. Seven studies were considered to be at high risk of bias, four at low risk and four at unclear risk. For removable retainers versus fixed retainers (three studies) there was low quality evidence that thermoplastic removable retainers provided slightly poorer stability in the lower arch than multistrand fixed retainers: MD (Little's Irregularity Index, 0 mm is stable) 0.6 mm (95% CI 0.17 to 1.03) and of less gingival bleeding with removable retainers: RR 0.53 (95%CI; 0.31 to 0.88). Patients found fixed retainers more acceptable to wear, with a mean difference on a visual analogue scale (VAS; 0 to 100; 100 being very satisfied) of -12.84 (95% CI -7.09 to -18.60).For different types of fixed retainers (four studies) data from three studies (228 patients) comparing polyethylene ribbon bonded retainer versus multistrand retainer were pooled showing no evidence of a difference in failure rates. RR = 1.10 (95%CI; 0.77 to 1.57).Pooled data from two trials (174

  6. A Citation Tracking System to Facilitate Sponsoring Institution Oversight of ACGME-Accredited Programs.

    Science.gov (United States)

    Long, Timothy R; Poe, John D; Zimmerman, Richard S; Rose, Steven H

    2012-12-01

    The Accreditation Council for Graduate Medical Education (ACGME) requires the graduate medical education committee and the designated institutional official to ensure that citations for noncompliance with the accreditation standards and institutional trends in citations are reviewed and corrected. To describe a citation tracking system (CTS) that uses Microsoft Office Access to efficiently catalogue, monitor, and document resolution of citations. The CTS was implemented in a sponsoring institution with oversight of 133 ACGME-accredited programs. The designated institutional official and the graduate medical education committee review all program letters of notification and enter citations into the CTS. A program-correction plan is required for each citation and is entered into the database. Open citations and action plans are reviewed by the graduate medical education committee and the designated institutional official on a quarterly basis, with decisions ranging from "closing" the citation to approving the action plan in process to requiring a new or modified action plan. Citation categories and subcategories are accessed on the ACGME website and entered into the CTS to identify trends. All 236 citations received since the 2006 Mayo School of Graduate Medical Education institutional site visit were entered into the CTS. On November 22, 2011, 26 of 236 citations (11%) were in active status with ongoing action plans, and 210 (89%) citations had been resolved and were closed. The CTS uses commercially available software to ensure citations are monitored and addressed and to simplify analysis of citation trends. The approach requires minimal staff time for data input and updates and can be performed without institutional information technology assistance.

  7. Real time transit dosimetry for the breath-hold radiotherapy technique: An initial experience

    Energy Technology Data Exchange (ETDEWEB)

    Piermattei, Angelo; Cilla, Savino; Grimaldi, Luca (Istituto di Fisica, Universitagrave Cattolica S. Cuore, Roma (Italy)) (and others)

    2008-08-15

    Introduction. The breath-hold is one of the techniques to obtain the dose escalation for lung tumors. However, the change of the patient's breath pattern can influence the stability of the inhaled air volume, IAV, used in this work as a surrogate parameter to assure the tumor position reproducibility during dose delivery. Materials. and method. In this paper, an Elekta active breathing coordinator has been used for lung tumor irradiation. This device is not an absolute spirometer and the feasibility study here presented developed (i) the possibility to select a specific range epsilon of IAV values comfortable for the patient and (ii) the ability of a transit signal rate, obtained by a small ion-chamber positioned on the portal image device, to supply in real time the in vivo isocenter dose reproducibility. Indeed, while the selection of the IAV range depends on the patient's ability to follow instructions for breath-hold, the monitoring can supply to the radiation therapist a surrogate of the tumor irradiation reproducibility. Results. The detection of the (image) in real time during breath-hold was used to determine the interfraction isocenter dose variations due to the reproducibility of the patient's breathing pattern. The agreement between the reconstructed and planned isocenter dose in breath-hold at the interfraction level was well within 1.5%, while in free breathing a disagreement up to 8% was observed. The standard deviation of the [image omitted] in breath-hold observed at the intrafraction level is a bit higher than the one obtained without the patient and this can be justified by the presence of a small residual tumor motion as heartbeat. Conclusion. The technique is simple and can be implemented for routine use in a busy clinic

  8. Dome diseases: party competition, legislative oversight and government accountability in three Canadian provinces

    OpenAIRE

    Marriott, Peter Anthony John

    2011-01-01

    This project compares the structure and operations of the provincial legislatures of British Columbia, Alberta and Ontario over approximately fifteen years to evaluate the ways in which their effectiveness at holding government accountable is enhanced or diminished by differing systems of party competition. British Columbia, Alberta and Ontario exemplify polarized two party, single party dominant and multi party systems, respectively. To evaluate the effectiveness of the legislatures under ...

  9. 加强会计监督的法律思考%Legal Thinking of Strengthen Accounting Oversight

    Institute of Scientific and Technical Information of China (English)

    杨沫

    2011-01-01

    Accounting supervision as one of the basic functions of accounting,in accordance with national laws and policies of various financial,regulatory oversight of accounting practice,the use of proper accounting information on economic activities of a comprehensive,integrated coordination,control,supervision,and supervision to achieve greater economic efficiency.The orderly functioning of the market economy can not do without accounting supervision.Now,with the deepening of economic reform,but also requires a strong accounting supervision.However,for various reasons,showing a weakening trend of the accounting oversight,resulting in the economic sphere and the economic behavior of non-standard criminal after another,therefore,to strengthen accounting oversight becomes increasingly important.%会计监督作为会计的基本职能之一,是依照国家法律和各项财经政策、规章制度对会计工作实行的监督,其利用正确的会计信息对经济活动进行全面、综合地协调、控制、监督、督促,以达到提高经济效益的目的。市场经济的有序运作离不开会计监督。目前,随着经济体制改革的深化,更需要强有力的会计监督。然而,由于种种原因,会计监督呈现出弱化态势,致使经济领域中不规范的经济行为与违法犯罪层出不穷,因此,强化会计监督就显得日益重要。

  10. Reduction of central venous catheter associated blood stream infections following implementation of a resident oversight and credentialing policy

    Directory of Open Access Journals (Sweden)

    West Cheri E

    2011-06-01

    Full Text Available Abstract Background This study assesses the impact that a resident oversight and credentialing policy for central venous catheter (CVC placement had on institution-wide central line associated bloodstream infections (CLABSI. We therefore investigated the rate of CLABSI per 1,000 line days during the 12 months before and after implementation of the policy. Methods This is a retrospective analysis of prospectively collected data at an academic medical center with four adult ICUs and a pediatric ICU. All patients undergoing non-tunneled CVC placement were included in the study. Data was collected on CLABSI, line days, and serious adverse events in the year prior to and following policy implementation on 9/01/08. Results A total of 813 supervised central lines were self-reported by residents in four departments. Statistical analysis was performed using paired Wilcoxon signed rank tests. There were reductions in median CLABSI rate (3.52 vs. 2.26; p = 0.015, number of CLBSI per month (16.0 to 10.0; p = 0.012, and line days (4495 vs. 4193; p = 0.019. No serious adverse events reported to the Pennsylvania Patient Safety Authority. Conclusions Implementation of a new CVC resident oversight and credentialing policy has been significantly associated with an institution-wide reduction in the rate of CLABSI per 1,000 central line days and total central line days. No serious adverse events were reported. Similar resident oversight policies may benefit other teaching institutions, and support concurrent organizational efforts to reduce hospital acquired infections.

  11. Teamwork for Oversight of Processes and Systems (TOPS). Implementation guide for TOPS version 2.0, 10 August 1992

    Science.gov (United States)

    Strand, Albert A.; Jackson, Darryl J.

    1992-01-01

    As the nation redefines priorities to deal with a rapidly changing world order, both government and industry require new approaches for oversight of management systems, particularly for high technology products. Declining defense budgets will lead to significant reductions in government contract management personnel. Concurrently, defense contractors are reducing administrative and overhead staffing to control costs. These combined pressures require bold approaches for the oversight of management systems. In the Spring of 1991, the DPRO and TRW created a Process Action Team (PAT) to jointly prepare a Performance Based Management (PBM) system titled Teamwork for Oversight of Processes and Systems (TOPS). The primary goal is implementation of a performance based management system based on objective data to review critical TRW processes with an emphasis on continuous improvement. The processes are: Finance and Business Systems, Engineering and Manufacturing Systems, Quality Assurance, and Software Systems. The team established a number of goals: delivery of quality products to contractual terms and conditions; ensure that TRW management systems meet government guidance and good business practices; use of objective data to measure critical processes; elimination of wasteful/duplicative reviews and audits; emphasis on teamwork--all efforts must be perceived to add value by both sides and decisions are made by consensus; and synergy and the creation of a strong working trust between TRW and the DPRO. TOPS permits the adjustment of oversight resources when conditions change or when TRW systems performance indicate either an increase or decrease in surveillance is appropriate. Monthly Contractor Performance Assessments (CPA) are derived from a summary of supporting system level and process-level ratings obtained from objective process-level data. Tiered, objective, data-driven metrics are highly successful in achieving a cooperative and effective method of measuring

  12. Teamwork for Oversight of Processes and Systems (TOPS). Implementation guide for TOPS version 2.0, 10 August 1992

    Science.gov (United States)

    Strand, Albert A.; Jackson, Darryl J.

    As the nation redefines priorities to deal with a rapidly changing world order, both government and industry require new approaches for oversight of management systems, particularly for high technology products. Declining defense budgets will lead to significant reductions in government contract management personnel. Concurrently, defense contractors are reducing administrative and overhead staffing to control costs. These combined pressures require bold approaches for the oversight of management systems. In the Spring of 1991, the DPRO and TRW created a Process Action Team (PAT) to jointly prepare a Performance Based Management (PBM) system titled Teamwork for Oversight of Processes and Systems (TOPS). The primary goal is implementation of a performance based management system based on objective data to review critical TRW processes with an emphasis on continuous improvement. The processes are: Finance and Business Systems, Engineering and Manufacturing Systems, Quality Assurance, and Software Systems. The team established a number of goals: delivery of quality products to contractual terms and conditions; ensure that TRW management systems meet government guidance and good business practices; use of objective data to measure critical processes; elimination of wasteful/duplicative reviews and audits; emphasis on teamwork--all efforts must be perceived to add value by both sides and decisions are made by consensus; and synergy and the creation of a strong working trust between TRW and the DPRO. TOPS permits the adjustment of oversight resources when conditions change or when TRW systems performance indicate either an increase or decrease in surveillance is appropriate. Monthly Contractor Performance Assessments (CPA) are derived from a summary of supporting system level and process-level ratings obtained from objective process-level data. Tiered, objective, data-driven metrics are highly successful in achieving a cooperative and effective method of measuring

  13. Analysis of Hold Down Force for IVTM in PGSFR

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Nak Hyun; Koo, Gyeong-Hoi [KAERI, Daejeon (Korea, Republic of)

    2015-05-15

    The PGSFR (Prototype Generation IV Sodium Cooled Fast Reactor) is a new design for a compact sodium-cooled fast nuclear reactor. The main components of the IVTM (In-Vessel Transfer Machine) for PGSFR are composed of the upper driving part, the main tube and the pantograph arm including the gripper. The bottom of the pantograph arm has a tapered feature machined into it at the interface where it contacts the surrounding core assemblies when the hold down is engaged. A tapered feature on the core hold down assembly engages features in the top of the core assemblies and may help to reduce the deflections at the bottom of the main structural support tube while under refueling loads. Hold down force is one of the most important parameter for design IVTM. Elastic FE analysis was performed to calculate hold down force and displacement. The hold down force and displacement are 3626.8 N and -2.27 mm, respectively. The calculated values will be used to design IVTM for PGSFR. The maximum reaction force of fuel assembly is 641.05 N. The calculated values will be used to design receptacle and lower grid plate for PGSFR.

  14. Safety-Related Contractor Activities at Nuclear Power Plants. New Challenges for Regulatory Oversight

    Energy Technology Data Exchange (ETDEWEB)

    Chockie, Alan [Chockie Group International, Inc., Seattle, WA (United States)

    2005-09-15

    The use of contractors has been an integral and important part of the design, construction, operation, and maintenance of nuclear power plants. To ensure the safe and efficient completion of contracted tasks, each nuclear plant licensee has developed and refined formal contract management processes to meet their specific needs and plant requirements. Although these contract management processes have proven to be effective tools for the procurement of support and components tailored to the needs of nuclear power plants, contractor-related incidents and accidents have revealed some serious weaknesses with the implementation of these processes. Identifying and addressing implementation problems are becoming more complicated due to organizational and personnel changes affecting the nuclear power industry. The ability of regulators and licensees to effectively monitor and manage the safety-related performance of contractors will likely be affected by forthcoming organization and personnel changes due to: the aging of the workforce; the decline of the nuclear industry; and the deregulation of nuclear power. The objective of this report is to provide a review of current and potential future challenges facing safety-related contractor activities at nuclear power plants. The purpose is to assist SKI in establishing a strategy for the proactive oversight of contractor safety-related activities at Swedish nuclear power plants and facilities. The nature and role of contractors at nuclear plants is briefly reviewed in the first section of the report. The second section describes the essential elements of the contract management process. Although organizations have had decades of experience with the a contract management process, there remain a number of common implantation weaknesses that have lead to serious contractor-related incidents and accidents. These implementation weaknesses are summarized in the third section. The fourth section of the report highlights the

  15. PBL og de sammensatte hold på kandidatuddannelser

    DEFF Research Database (Denmark)

    Engen, Mie; Fallov, Mia Arp; Jensen, Rune Hagel Skaarup

    Denne rapport omhandler pædagogiske udfordringer og muligheder i Aalborgs Problembaserede Læringstilgang (PBL), når den omsættes til pædagogisk og didaktisk handling på kandidatuddannelser med sammensatte hold. Sammensatte hold betyder i denne sammenhæng kandidatuddannelser, hvor de optagne...... studerende har meget forskellige uddannelsesmæssige baggrunde. Rapporten formidler en didaktisk ramme for, hvordan PBL kan tilgås, når studerende på et kandidathold er meget forskellige, med henblik på at udnytte kompetencerne på de sammensatte hold bedst muligt og derved øge læringspotentialet....

  16. C-14/I-29 Preservation and Hold Time Survey

    Energy Technology Data Exchange (ETDEWEB)

    Kitchen, S. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-04-08

    Preservation and hold time of radionuclides must account for both nuclear half-lives and nonnuclear loss mechanisms, but variations in the latter are often neglected. Metals-based defaults are inappropriate for long-lived non-metals C-14 and I-129, which are vulnerable to chemical and biological volatilization. Non-acidification is already widely practiced for them. Recommended addition measures from radiological and chemical literature include glass containers where possible, water filtration where possible, headspace minimization, light shielding, cold (4°C) storage and unfiltered water hold time of 28 days. Soil hold time may need to be shortened when water-logged, excessively sandy, or still adjusting to significant new contamination.

  17. Internationalization and Corporate Cash Holdings: Evidence from Brazil and Mexico

    Directory of Open Access Journals (Sweden)

    Newton Arata

    2015-05-01

    Full Text Available This research expands on previous studies of cash holdings and their determinants by studying the relationship between the degree of internationalization and the level of corporate cash holdings. We used a sample of nonfinancial, publicly traded companies from Brazil and Mexico for the period from 2006 to 2010. Our results suggest that the degree of internationalization is a determinant of cash, and that cash holding increases quadratically as the degree of company internationalization grows. Such behavior was different from the North American company studies in Chiang and Wang (2011. Similar to previous studies, both Trade-off and Pecking Order predictions are relevant control variables in our model. Finally, companies held less cash on their balance sheets during the precrisis period.

  18. Investasi: Komparasi Strategi Buy and Hold dengan Pendekatan Teknikal

    Directory of Open Access Journals (Sweden)

    Natica Ardani

    2012-01-01

    Full Text Available This research aims to analyse effectivity of technical analysis moving average compare to buy and hold strategy on index LQ-45 (as emerging market and S&P500 (as developed market. Using descriptive approach, this research analysed by metastock program with moving average exponential crossovers method. This research data samples use LQ45 and S&P500 from year 2001-2011. The findings of this research indicate that technical analysis more effective when economic situation on crisis (bearish. Whereas buy and hold strategy more effective on good economic condition (bullish. The results consistent for LQ-45 and S&P500.

  19. Holding Pressure and Its Influence on Quality in PIM Technology

    Directory of Open Access Journals (Sweden)

    Pavel Petera

    2012-01-01

    Full Text Available The PIM (powder injection molding process consists of several steps in which faults can occur. The quality of the part that is produced usually cannot be seen until the end of the process. It is therefore necessary to find a way to discover the fault earlier in the process. The cause of defects is very often “phase separation” (inhomogeneity in powder distribution, which can also be influenced by the holding pressure. This paper evaluates the powder distribution with a new method based on density measurement. Measurements were made using various holding pressure values.

  20. The Effect of Holding a Research Chair on Scientists’ Impact

    Energy Technology Data Exchange (ETDEWEB)

    Mirnezami, S.R.; Beaudry, C.

    2016-07-01

    This paper examines the effect of holding Canada Research Chair (CRC) on a scientist’s number of citations as a measure of research impact, based on an econometric analysis with combined data on Quebec scientists’ funding and journal publication. Using Generalized Least Square (GLS) method for regression analysis, the results show that holding either tier-1 or tier- 2 of CRC significantly and positively results in conducting research with higher impact. This finding, however, does not necessarily imply that the others are the lesser scientists. (Author)

  1. An evaluation of the role and effectiveness of institutional biosafety committees in providing oversight and security at biocontainment laboratories.

    Science.gov (United States)

    Race, Margaret S; Hammond, Edward

    2008-03-01

    Institutional biosafety committees (IBCs) have been charged with the oversight and review of biosafety at thousands of biocontainment labs nationwide, hundreds of which are high-level BSL-3 and BSL-4 labs. In light of the recent rapid proliferation of BSL-3 and BSL-4 facilities and the increases in research in the areas of biodefense, select agents, recombinant DNA, and synthetic biology and dual-use research, questions have been raised about whether IBCs are fulfilling their oversight responsibilities. This article reviews information on the responsibilities and expectations of IBCs as currently constituted and provides an analysis of IBC performance from survey data of hundreds of research institutions over the past several years. The findings highlight serious ongoing problems with IBCs' adherence to NIH Guidelines. This raises questions about the current voluntary governance framework as an effective system to monitor and oversee U.S. research facilities, including high-containment facilities, and their research activities. The findings strongly suggest the need for immediate improvement or replacement of the IBC system.

  2. From cradle-to-grave at the nanoscale: gaps in U.S. regulatory oversight along the nanomaterial life cycle.

    Science.gov (United States)

    Beaudrie, Christian E H; Kandlikar, Milind; Satterfield, Terre

    2013-06-04

    Engineered nanomaterials (ENMs) promise great benefits for society, yet our knowledge of potential risks and best practices for regulation are still in their infancy. Toward the end of better practices, this paper analyzes U.S. federal environmental, health, and safety (EHS) regulations using a life cycle framework. It evaluates their adequacy as applied to ENMs to identify gaps through which emerging nanomaterials may escape regulation from initial production to end-of-life. High scientific uncertainty, a lack of EHS and product data, inappropriately designed exemptions and thresholds, and limited agency resources are a challenge to both the applicability and adequacy of current regulations. The result is that some forms of engineered nanomaterials may escape federal oversight and rigorous risk review at one or more stages along their life cycle, with the largest gaps occurring at the postmarket stages, and at points of ENM release to the environment. Oversight can be improved through pending regulatory reforms, increased research and development for the monitoring, control, and analysis of environmental and end-of-life releases, introduction of periodic re-evaluation of ENM risks, and fostering a "bottom-up" stewardship approach to the responsible management of risks from engineered nanomaterials.

  3. Why budget accountability fails? The elusive links between parliaments and audit agencies in the oversight of the budget

    Directory of Open Access Journals (Sweden)

    CARLOS SANTISO

    2015-09-01

    Full Text Available ABSTRACTParliaments and audit agencies have critical and complementary roles in the oversight of the budget and the enforcement of government accountability. Yet, the nexus between parliaments and audit agencies is one of the weakest links in the accountability chain, generating an accountability gap in the budget process. This articles analyses the interactions between parliaments and audit agencies in the oversight of government finances during the latter stages of the budget process. Using proxies to evaluate the quality of those linkages, such as the follow-up to audit findings and the discharge of government, it shows important dysfunctions in the interactions between parliaments and audit agencies due to a combination of technical capacity constraints and political economy disincentives. It suggests that the effective functioning of the system of checks and balances in public budgeting critically hinges on the agility of the linkages between accountability institutions. As such, the failure of budget accountability is due to systemic dysfunctions in the systems of accountability, rather than the failure of an individual accountability institution acting in isolation. In addition, the effectiveness of the horizontal accountability architecture depends on the political economy incentives shaping the budget process, which are generated by the interactions between the choice of institutional design and budget rules, with the degree of political competition and electoral rules.

  4. Iron supplementation reduces the frequency and severity of breath-holding attacks in non-anaemic children

    Directory of Open Access Journals (Sweden)

    Anthony Zehetner

    2011-11-01

    Full Text Available Iron supplementation reduces the frequency and severity of breath-holding attacks (BHAs, particularly in children with iron deficiency. The issue of iron supplementation is less clear for Westernized children with BHAs who present to an outpatient community clinic and are not iron-deficient. This is the first reported case series of iron-replete children with frequent and disabling breath-holding attacks who have responded to a course of oral iron supplementation. This intervention is safe, improves quality of life for both child and carer, and is significantly cost-effective in terms of health resource utilization.

  5. Experience with Regulatory Strategies in Nuclear Power Oversight. Part 1: An International Exploratory Study. Part 2: Workshop Discussions and Conclusions

    Energy Technology Data Exchange (ETDEWEB)

    Melber, Barbara [Melber Consulting, Seattle, WA (United States); Durbin, Nancy E. [Nancy E. Durbin Consulting, Kirkland, WA (United States); Tael, Irene (ed.) [Swedish Nuclear Power Inspectorate, Stockholm (Sweden)

    2005-03-01

    This report presents the results of a study which explored the use of six different regulatory strategies for oversight of commercial nuclear power facilities: prescriptive, case-based, outcome-based, risk-based, process-based, and self-assessment strategies. Information was collected on experiences with the use of these different regulatory strategies from experts from nuclear regulatory agencies in Canada, Finland, Spain, Sweden, the United Kingdom and the United States. Systematic, structured open-ended interviews with expert regulators with extensive experience were used in order to understand how regulatory strategies are applied in practice. Common patterns were identified regarding: Experts' perspectives on the major benefits and difficulties of using specific regulatory strategies; Experts' experiences with using regulatory strategies for three areas of oversight-design and modifications, quality systems, and training and qualifications; Expert views of the consequences of different regulatory strategies; Issues that emerged in the interviews regarding regulatory strategies. The major benefit of a prescriptive strategy was that it is clear about requirements and expectations. The major difficulties were that it takes responsibility away from the licensee, it requires a high use of regulator resources and is rigid and difficult to change. A case-based strategy had the key benefit of flexibility for adapting regulatory responses to unique situations, but the difficulties of being considered arbitrary, inconsistent, and unfair and requiring heavy resource use. An outcome-based strategy had the main benefit of allowing licensees to decide the best way to operate m order to meet safety goals, but the major difficulty of identifying appropriate ways to measure safety performance. The major benefit of a risk strategy was its use co prioritize safety issues and allocate resources. However, it was considered inappropriate to use as a stand alone strategy

  6. Experience with Regulatory Strategies in Nuclear Power Oversight. Part 1: An International Exploratory Study. Part 2: Workshop Discussions and Conclusions

    Energy Technology Data Exchange (ETDEWEB)

    Melber, Barbara [Melber Consulting, Seattle, WA (United States); Durbin, Nancy E. [Nancy E. Durbin Consulting, Kirkland, WA (United States); Tael, Irene (ed.) [Swedish Nuclear Power Inspectorate, Stockholm (Sweden)

    2005-03-01

    This report presents the results of a study which explored the use of six different regulatory strategies for oversight of commercial nuclear power facilities: prescriptive, case-based, outcome-based, risk-based, process-based, and self-assessment strategies. Information was collected on experiences with the use of these different regulatory strategies from experts from nuclear regulatory agencies in Canada, Finland, Spain, Sweden, the United Kingdom and the United States. Systematic, structured open-ended interviews with expert regulators with extensive experience were used in order to understand how regulatory strategies are applied in practice. Common patterns were identified regarding: Experts' perspectives on the major benefits and difficulties of using specific regulatory strategies; Experts' experiences with using regulatory strategies for three areas of oversight-design and modifications, quality systems, and training and qualifications; Expert views of the consequences of different regulatory strategies; Issues that emerged in the interviews regarding regulatory strategies. The major benefit of a prescriptive strategy was that it is clear about requirements and expectations. The major difficulties were that it takes responsibility away from the licensee, it requires a high use of regulator resources and is rigid and difficult to change. A case-based strategy had the key benefit of flexibility for adapting regulatory responses to unique situations, but the difficulties of being considered arbitrary, inconsistent, and unfair and requiring heavy resource use. An outcome-based strategy had the main benefit of allowing licensees to decide the best way to operate m order to meet safety goals, but the major difficulty of identifying appropriate ways to measure safety performance. The major benefit of a risk strategy was its use co prioritize safety issues and allocate resources. However, it was considered inappropriate to use as a stand alone strategy

  7. Comparative Survey of Holding Positions for Reducing Vaccination Pain in Young Infants

    Science.gov (United States)

    Yin, Hui-Chu; Cheng, Shao-Wen; Yang, Chun-Yuh; Chiu, Ya-Wen

    2017-01-01

    Background. Infant holding position may reduce vaccination pain. However, the optimal position for young infants remains controversial. Objectives. To compare the effectiveness of holding infants in the supine position and the effectiveness of holding infants in upright position for relieving acute pain from vaccine injection. Methods. This prospective cohort study enrolled 6–12-week-old healthy infants. We examined infant pain responses by evaluating the following three categories: (1) crying, (2) irritability, and (3) facial expression. Results. In total, 282 infants were enrolled, with 103 and 179 held in the supine and upright positions, respectively. At 30 s after vaccination, the infants in the supine position showed a larger decrease in crying (p pained facial expression (p = 0.001) than did those in the upright position. However, there was no significant difference in pain response between two groups at 180 s after intervention. Conclusion. In 2-month-old infants, the supine position may reduce acute pain more effectively than does the upright position. Our findings provide a clinical strategy for relieving vaccination pain in young infants.

  8. Centralized HIV Program Oversight: An Investigation of a Case Series of New HIV Infections among US Army Soldiers, 2012 to 2013.

    Science.gov (United States)

    Pacha, Laura A; Hakre, Shilpa; Myles, Otha; Sanders-Buell, Eric E; Scoville, Stephanie L; Kijak, Gustavo H; Price, Michael W; Mody, Rupal M; Liu, Ying; Miller, Shana L; Pham, Phuc T; Michael, Nelson L; Kim, Jerome H; Peel, Sheila A; Tovanabutra, Sodsai; Jagodzinski, Linda L; Cersovsky, Steven B; Scott, Paul T

    2015-11-01

    Centralized HIV program oversight and repeal of the Department of Defense policy "Don't Ask Don't Tell" permitted characterization of HIV transmission among soldiers assigned to a large US Army base continental United States from 2012 to 2013. An investigation of a greater than expected number of new HIV infections among soldiers was initiated to characterize transmission and identify opportunities to disrupt transmission and deliver services.All soldiers who were assigned to the base at the time of their first positive HIV test and who had their first positive HIV test in 2012 or in the first 6 months of 2013 and who had a clinical genotype available for analysis were eligible for inclusion in the investigation.All patients (n = 19) were men; most were black (52%) and less than 30 years old (64%). Fifteen of the 19 patients participated in in-depth interviews. Eighty percent were men who have sex with men who reported multiple sex partners having met through social and electronic networks. All were subtype B infections. Significant knowledge gaps and barriers to accessing testing and care in the military healthcare system were identified. Most (58%) belonged to transmission networks involving other soldiers.This investigation represents an important step forward in on-going efforts to develop a comprehensive understanding of transmission networks in the Army that can inform delivery of best practices combination prevention services. The Army is developing plans to directly engage individuals in key affected populations most at risk for HIV infection to identify and address unmet needs and expand delivery and uptake of prevention services. Further investigation is underway and will determine whether these findings are generalizable to the Army.

  9. Astronaut Alan Bean holds Special Environmental Sample Container

    Science.gov (United States)

    1969-01-01

    Astronaut Alan L. Bean, lunar module pilot for the Apollo 12 lunar landing mission, holds a Special Environmental Sample Container filled with lunar soil collected during the extravehicular activity (EVA) in which Astronauts Charles Conrad Jr., commander, and Bean participated. Connrad, who took this picture, is reflected in the helmet visor of the lunar module pilot.

  10. Astronaut Dale Gardner holds up for sale sign after EVA

    Science.gov (United States)

    1984-01-01

    Astronaut Dale A. Gardner, having just completed the major portion of his second extravehicular activity (EVA) period in three days, holds up a 'for sale' sign. Astronaut Joseph P. ALlen IV, who also participated in the two EVA's, is reflected in Gardner's helmet visor. A portion of each of two recovered satellites is in the lower right corner, with Westar nearer Discovery's aft.

  11. Water holding capacity and swelling of casein hydrogels

    NARCIS (Netherlands)

    de Kruif, C; Anema, Skelte G.; Zhu, Changjun; Havea, Palatasa; Coker, Christina

    2015-01-01

    The water holding capacity of casein gels was investigated by measuring the swelling and de-swelling under a variety of conditions of temperature and salt concentration. Transglutaminase cross-linked sodium caseinate (15% w/w) gels will swell in good solvents or shrink in poor solvents until an equi

  12. The myth of the early aviation patent hold-up

    DEFF Research Database (Denmark)

    Katznelson, Ron D; Howells, John

    2015-01-01

    The prevailing historical accounts of the formation of the U.S. aircraft “patent pool” in 1917 assume the U.S. Government necessarily intervened to alleviate a patent hold-up among private aircraft manufacturers. We show these accounts to be inconsistent with the historical facts. We show that de...

  13. Holding Period Return-Risk Modeling: Ambiguity in Estimation

    NARCIS (Netherlands)

    W.G.P.M. Hallerbach (Winfried)

    2003-01-01

    textabstractIn this paper we explore the theoretical and empirical problems of estimating average (excess) return and risk of US equities over various holding periods and sample periods. Our findings are relevant for performance evaluation, for estimating the historical equity risk premium, and for

  14. 31 CFR 223.16 - List of certificate holding companies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false List of certificate holding companies. 223.16 Section 223.16 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE SURETY COMPANIES DOING...

  15. 33 CFR 100.30 - Approval required for holding event.

    Science.gov (United States)

    2010-07-01

    ... event. 100.30 Section 100.30 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... holding event. (a) An event for which application is required under § 100.15(a) shall be held only after approval of such event by the District Commander, except that applications referred to a State under § 100...

  16. 77 FR 32881 - Supervised Securities Holding Company Registration

    Science.gov (United States)

    2012-06-04

    ... 81 Supervised Securities Holding Company Registration AGENCY: Board of Governors of the Federal...'' or ``Act''), which permits nonbank companies that own at least one registered securities broker or dealer, and that are required by a foreign regulator or provision of foreign law to be subject to...

  17. Holding Period Return-Risk Modeling: Ambiguity in Estimation

    NARCIS (Netherlands)

    W.G.P.M. Hallerbach (Winfried)

    2003-01-01

    textabstractIn this paper we explore the theoretical and empirical problems of estimating average (excess) return and risk of US equities over various holding periods and sample periods. Our findings are relevant for performance evaluation, for estimating the historical equity risk premium, and for

  18. Great United Petroleum Holding Co Ltd Announced Its Establishment

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ China's largest private petroleum group - the Great United Petroleum Holding Co., Ltd (GUPC) announced its establishment in Beijing on June 29th, marking that the private enterprises are moving from being decentralized to unification, China's private oil industry is entering on a new stage of development.

  19. Mixed Dominance and the Manner of Holding a Pencil.

    Science.gov (United States)

    Lovell, Virginia K.

    1982-01-01

    Reports on an informal study that revealed that a significant number of people who hold a pencil with two fingers and a thumb have mixed cerebral dominance, that more females than males have mixed dominance, and that those with mixed dominance tend to be more imaginative. (FL)

  20. U. S. Army Directory of Technical Information Holdings and Services.

    Science.gov (United States)

    Vincent, Dale L.

    The directory identifies 111 Army sources of technical information that include 2200 specialized subject areas. The sources are indexed by subject matter, and name of holding, so that a searcher can find a description of all available indexed Army information services, with details on scope and size of collections, services available, and means of…

  1. 31 CFR 316.5 - Limitation on holdings.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Limitation on holdings. 316.5 Section 316.5 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT OFFERING OF UNITED STATES SAVINGS BONDS, SERIES E §...

  2. Comparison of left and right ventricular ejection and filling parameters by fast cine MR imaging in breath-hold technique: clinical study of 42 patients with cardiomyopathy and coronary heart disease; Vergleich links- und rechtsventrikulaerer Auswurf- und Fuellungsparameter des Herzens mittels Cine MRT in Atemanhaltetechnik: klinische Studie an 42 Patienten mit Kardiomyopathie und koronarer Herzerkrankung

    Energy Technology Data Exchange (ETDEWEB)

    Rominger, M.B.; Bachmann, G.F.; Geuer, M.; Puzik, M.; Rau, W.S. [Giessen Univ. (Germany). Diagnostische Radiologie; Ricken, W.W. [Kerckhoff-Klinik GmbH, Bad Nauheim (Germany). Abt. Kardiologie

    1999-06-01

    Purpose: Quantification of left and right ventricular filling and ejection of localized and diffuse heart diseases with fast cine MR imaging in breath-hold technique. Methods: 42 patients (14 idiopathic dilated cardiomyopathies (DCM), 13 hypertrophic cardiomyopathies (HCM) and 15 coronary artery diseases (CAD)) and 10 healthy volunteers were examined. Time-volume-curves of three left ventricular and one right ventricular slices were evaluated and peak ejection and filling rates (PER, PFR end-diastolic volume (EDV)/s) time to PER and PFR (TPER, TPFR ms) and time of end-systole (TSYS in % RR-intervall) were calculated. Results: There were significant regional and left-/right-sided differences of the filling and ejection of both ventricles within and between the different groups. In DCM the left ventricular PFR was reduced (DCM 3.1 EDV/s; volunteers 4.9 EDV/s) and Z-SYS prolonged (DCM 50.1%; volunteers 35.4%). In CAD there were localized decreased filling rates in comparison to the normal volunteer group (left ventricle: basal: 2.9 and 6.3 EDV/s, apical: 4.4 and 6.3 EDV/s; right ventricle: 3.6 and 5.7 EDV/s). HCM typically showed an isovolumetric lengthening of the endsystole. Conclusions: Cardiac MR imaging in breath-hold technique is suitable for measuring contraction and relaxation disturbances of localized and diffuse heart diseases by means of ejection and filling volume indices. (orig.) [Deutsch] Ziel: Quantifizierung der links- und rechtsventrikulaeren Fuellung und des Auswurfs bei umschriebenen und diffusen Herzerkrankungen mittels schneller Cine MR Bildgebung in Atemanhaltetechnik. Methoden: Untersucht wurden 42 Patienten (14 dilatative Kardiomyopathien (DCM), 13 hypertrophe obstruktive Kardiomyopathien (HCM) und 15 koronare Herzerkrankungen (KHK)) und 10 Probanden. Von drei linksventrikulaeren und einer rechtsventrikulaeren Einzelschicht wurden Zeit-Volumen-Kurven erstellt, aus denen die maximale Auswurf- und Fuellrate (MAR) (MFR eddiastolisches Volumen (EDV

  3. The physiology and pathophysiology of human breath-hold diving.

    Science.gov (United States)

    Lindholm, Peter; Lundgren, Claes E G

    2009-01-01

    This is a brief overview of physiological reactions, limitations, and pathophysiological mechanisms associated with human breath-hold diving. Breath-hold duration and ability to withstand compression at depth are the two main challenges that have been overcome to an amazing degree as evidenced by the current world records in breath-hold duration at 10:12 min and depth of 214 m. The quest for even further performance enhancements continues among competitive breath-hold divers, even if absolute physiological limits are being approached as indicated by findings of pulmonary edema and alveolar hemorrhage postdive. However, a remarkable, and so far poorly understood, variation in individual disposition for such problems exists. Mortality connected with breath-hold diving is primarily concentrated to less well-trained recreational divers and competitive spearfishermen who fall victim to hypoxia. Particularly vulnerable are probably also individuals with preexisting cardiac problems and possibly, essentially healthy divers who may have suffered severe alternobaric vertigo as a complication to inadequate pressure equilibration of the middle ears. The specific topics discussed include the diving response and its expression by the cardiovascular system, which exhibits hypertension, bradycardia, oxygen conservation, arrhythmias, and contraction of the spleen. The respiratory system is challenged by compression of the lungs with barotrauma of descent, intrapulmonary hemorrhage, edema, and the effects of glossopharyngeal insufflation and exsufflation. Various mechanisms associated with hypoxia and loss of consciousness are discussed, including hyperventilation, ascent blackout, fasting, and excessive postexercise O(2) consumption. The potential for high nitrogen pressure in the lungs to cause decompression sickness and N(2) narcosis is also illuminated.

  4. Afghanistan’s High office of Oversight: Personal Asset Declarations of High Ranking Afghan Government Officials Are Not Consistently Registered and Verified

    Science.gov (United States)

    2016-09-19

    and location (inside or outside Afghanistan; list country if outside Afghanistan) Source of income Personal Effects (if valued at more than 3,000...SIGAR Special Inspector General for Afghanistan Reconstruction AFGHANISTAN’S HIGH OFFICE OF OVERSIGHT: PERSONAL ASSET...registration and complaints directorates collect declarations of personal assets from public officials of the Afghan government, receive complaints from

  5. Oversight of the Radiation Exposure Compensation Act. Hearing of the Committee on Labor and Human Resources, United States Senate, One Hundred Third Congress, First Session, June 5, 1993

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-12-31

    The hearing addresses oversight of The Radiation Exposure Compensation Act and considers the need for changes in the 1990 legislation because it is not working as intended. Statements of government and industry officials are included, along with documents submitted for the record.

  6. 26 CFR 1.553-1 - Foreign personal holding company income.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Foreign personal holding company income. 1.553-1... TAX (CONTINUED) INCOME TAXES (CONTINUED) Foreign Personal Holding Companies § 1.553-1 Foreign personal holding company income. Foreign personal holding company income shall consist of the items defined...

  7. Simulation of assembling cargo-hold spaceship pallets

    Science.gov (United States)

    Du, Ruizhao; Wang, Pengfei; Wu, Qianru; Jing, Chenchen

    2017-06-01

    The pallet is the load-carrying body between cargo and cargo-hold cabin. Due to the narrow space of cargo-hold cabin, it is difficult for workers to operate. During the installation process of the pallet, it can easily collide with cabin. Based on the installation technology of the pallet, the assembly process of pallet is simulated and analyzed in this paper. The main installation process includes the lifting of pallet, the process of pallet entering the cabin and the assembling of separating device. In the simulation, the practicability of tooling, the standing position of operators, visibility and accessibility of operations are analyzed to determine the risk points in the installation process of pallet. According to the simulation results, feasibility of pallet installation is verified, space requirements for installation are given, and position requirements and posture requirements of workers in the operation process can also be achieved.

  8. Emulsifying salt increase stability of cheese emulsions during holding

    DEFF Research Database (Denmark)

    Hougaard, Anni Bygvrå; Sijbrandij, Anna G.; Varming, Camilla

    2015-01-01

    In cheese powder production, cheese is mixed and melted with water and emulsifying salt to form an emulsion (cheese feed) which is required to remain stable at 60°C for 1h and during further processing until spray drying. Addition of emulsifying salts ensures this, but recent demands for reduction...... of sodium and phosphate in foods makes production of cheese powder without or with minimal amounts of emulsifying salts desirable. The present work uses a centrifugation method to characterize stability of model cheese feeds. Stability of cheese feed with emulsifying salt increased with holding time at 60°C......, especially when no stirring was applied. No change in stability during holding was observed in cheese feeds without emulsifying salt. This effect is suggested to be due to continued exerted functionality of the emulsifying salt, possibly through reorganizations of the mineral balance....

  9. A distribution-free newsvendor problem with nonlinear holding cost

    Science.gov (United States)

    Pal, Brojeswar; Sankar Sana, Shib; Chaudhuri, Kripasindhu

    2015-05-01

    In this paper, we analyse a single-period newsvendor model to determine the optimal order quantity where the customers' balking occurs.This scenario occurs when the customers are opposed to buy a product for various reasons, such as decreasing quality of product, product is not as good as fresh when it reaches under a threshold level, etc. The model is investigated by assuming that the holding cost function depends on order quantity and the inventory level at which customer balking occurs depends on holding cost. The model allows partial backlogging and permits part of the backlogged shortages to turn into lost sales. We develop the model without taking any specific distributional form of demand, only assuming the mean and the variance of the distribution of demand. Finally, we illustrate the model by numerical examples and compare our distribution-free model with the specific distributional form of demand.

  10. The carbon holdings of northern Ecuador's mangrove forests

    CERN Document Server

    Hamilton, Stuart E; Borbor, Mercy; Millones, Marco

    2016-01-01

    Within a GIS environment, we combine field measures of mangrove diameter, mangrove species distribution, and mangrove density with remotely sensed measures of mangrove location and mangrove canopy cover to estimate the mangrove carbon holdings of northern Ecuador. We find that the four northern estuaries of Ecuador contain approximately 7,742,999 t (plus or minus 15.47 percent) of standing carbon. Of particular high carbon holdings are the Rhizophora mangle dominated mangrove stands found in-and-around the Cayapas-Mataje Ecological Reserve in northern Esmeraldas Province, Ecuador and certain stands of Rhizophora mangle in-and-around the Isla Corazon y Fragata Wildlife Refuge in central Manabi Province, Ecuador. Our field driven mangrove carbon estimate is higher than all but one of the comparison models evaluated. We find that basic latitudinal mangrove carbon models performed at least as well, if not better, than the more complex species based allometric models in predicting standing carbon levels. In additi...

  11. Ensuring the safety of living kidney donors and recipients in China through ethics committee oversight: an early experience.

    Science.gov (United States)

    Lei, Z; Lulin, M; Guoliang, W; Xiaofei, H

    2008-09-01

    In 2007, the Regulation on Human Organ Transplantation was enacted in China requiring the establishment of ethics committees to oversee living donor organ transplantation and establishing specific requirements that must be met. We established an Ethics Committee on Organ Transplantation at Peking University Third Hospital, and described its composition, its methods and operating procedures in the examination and approval of living-related donor kidney transplantation (LRDKT) and our initial experience. All 60 proposed cases of LRDKT were presented to the Ethics Committee for discussion, among which 53 cases were approved and seven cases were disapproved due to a variety of reasons that are discussed. The Ethics Committee on Organ Transplantation plays an important role in the ethical oversight of living-related donor organ transplantation in order to ensure to the greatest extent possible the safety, rights and interests of donors and recipients.

  12. The impact of masculinity on safety oversights, safety priority and safety violations in two male-dominated occupations

    DEFF Research Database (Denmark)

    Nielsen, Kent; Hansen, Claus D.; Bloksgaard, Lotte;

    2015-01-01

    outcomes, whereas trait-based theories do not show strong associations with safety outcomes. Implications The association between norm-based masculinity and safety measures might be used in tailoring and developing new preventive measures that specifically address masculinity and male role norms....... and safety violations in two male-dominated occupations using both a trait-based and a norm-based approach to masculinity. Methods Questionnaires covering trait-based (Bem Sex Role Inventory, BSRI) and norm-based (Male Role Norms Inventory – Revised, MRNI-R) measures of masculinity, three safety......-related context factors (safety leadership, commitment of the safety representative, and safety involvement) and three safety-related outcome factors (safety violations, safety oversights and safety priority) were administered twice 12 months apart to Danish ambulance workers (n = 1157) and slaughterhouse workers...

  13. Mort User's Manual: For use with the Management Oversight and Risk Tree analytical logic diagram

    Energy Technology Data Exchange (ETDEWEB)

    Knox, N.W.; Eicher, R.W.

    1992-02-01

    This report contains the User's Manual for MORT (Management Oversight and Risk Tree), a logic diagram in the form of a work sheet'' that illustrates a long series of interrelated questions. MORT is a comprehensive analytical procedure that provides a disciplined method for determining the causes and contributing factors of major accidents. Alternatively, it serves as a tool to evaluate the quality of an existing system. While similar in many respects to fault tree analysis, MORT is more generalized and presents over 1500 specific elements of an ideal universal'' management program for optimizing environment, safety and health, and other programs. This User's Manual is intended to be used with the MORT diagram dated February 1992.

  14. Legal Statement authorized by Veken Holding Group Co.,Ltd.

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    According to Patent Law of the People’s Republic of China,Implementing Regulations of the Patent Law of the People’s Republic of China,and other laws and regulations,Zhejiang Heyi Law Office has been authorized by Veken Holding Group Co.,Ltd.("Veken Group")to announce the statement as below to protect the legal rights of the patentee.

  15. PCV Holding: Who’s next? - Planning the Succession

    OpenAIRE

    Ramos, Beatriz Maria Venâncio

    2014-01-01

    This paper is a case study on a family business – PCV Holding – established in Mozambique. Having survived three generations and experiencing one of the most intense periods of growth, a tough issue emerges which is capable of compromising the future of the business: The Succession -How to transfer the management and ownership to the next generation while ensuring a fair process. Through several meetings with the board members and owners, I had the opportunity to understand the business an...

  16. International Reserve Holdings with Sovereign Risk and Costly Tax Collection

    OpenAIRE

    Aizenman, Joshua; Nancy P. Marion

    2003-01-01

    This paper analyzes the international reserve-holding behavior of developing countries. It shows that political-economy considerations modify the optimal reserve level determined by efficiency criteria. A country characterized by volatile output, inelastic demand for fiscal outlays, high tax collection costs and sovereign risk will want to accumulate international reserves as well as external debt. Efficiency considerations imply that reserves are optimal when the benefits they provide for in...

  17. Effects of proactive population-based nephrologist oversight on progression of chronic kidney disease: a retrospective control analysis

    Directory of Open Access Journals (Sweden)

    Lee Brian

    2012-08-01

    Full Text Available Abstract Background Benefits of early nephrology care are well-established, but as many as 40% of U.S. patients with end-stage renal disease (ESRD do not see a nephrologist before its onset. Our objective was to evaluate the effect of proactive, population-based nephrologist oversight (PPNO on chronic kidney disease (CKD progression. Methods Retrospective control analysis of Kaiser Permanente Hawaii members with CKD using propensity score matching methods. We matched 2,938 control and case pairs of individuals with stage 3a CKD for the pre-PPNO period (2001–2004 and post-PPNO period (2005–2008 that were similar in other characteristics: age, gender, and the presence of diabetes and hypertension. After three years, we classified the stage outcomes for all individuals. We assessed the PPNO effect across all stages of progression with a χ2- test. We used the z-score test to assess the proportional differences in progression within a stage. Results The progression within the post-PPNO period was less severe and significantly different from the pre-PPNO period (p = 0.027. Within the stages, there were 2.6% more individuals remaining in 3a in the post-period (95% confidence interval [CI], 1.5% to 3.8%; P value P value = 0.0017, 3a to 4/5 was 0.2% less (95% CI, 0.0% to 0.87%; P value = 0.26, and 3a to ESRD was 0.24% less (95% CI, 0.0% to 0.66%, P value = 0.10. Conclusions Proactive, population-based nephrologist oversight was associated with a statistically significant decrease in progression. With enabling health information technology, risk stratification and targeted intervention by collaborative primary and specialty care achieves population-level care improvements. This model may be applicable to other chronic conditions.

  18. Nurse practitioner perceptions of the impact of physician oversight on quality and safety of nurse practitioner practice.

    Science.gov (United States)

    Lowery, Bobby; Scott, Elaine; Swanson, Mel

    2016-08-01

    Nurse practitioner (NP) regulation and physician oversight (PO) of NP practice are inextricably intertwined. A flexible, well-prepared workforce is needed to meet consumer healthcare needs. All outcome studies have revealed that NPs provide safe, effective, quality care with outcomes equal to or better than that of physicians or physician assistants. Variability in state regulation of NP practice limits the full deployment of these proven healthcare providers, threatens the quality and safety of NP-delivered care, and limits consumer choice in healthcare access. The purpose of this study was to document NP perceptions of the impact of PO on the safety and quality of NP practice. A total of 1139 NP respondents completed an exploratory survey, Impact of Regulatory Requirements for Physician Oversight on Nurse Practitioner Practice. Participants were asked their perceptions of the impact of PO on patient care and NP practice. Descriptive statistics on the state of residence regulatory requirements and personal demographics were also collected. NP perceptions of the impact of PO on the safety and quality of NP practice were predicted by NP experience and state regulatory environment ranking. The results of this study have implications for educators, policy makers, and nursing advocacy groups seeking to increase access to care in U.S. Study participants perceived that requirements for PO impacted their practice and may jeopardize patient safety. An understanding of the impact of influences on regulatory processes is critical to ensuring full deployment of NPs as interprofessional leaders to meet current and future healthcare access. ©2015 American Association of Nurse Practitioners.

  19. Pengaruh Teknik Hold Relax terhadap Penambahan Jarak Gerak Abduksi Sendi Bahu pada Frozen Shoulder di Ratulangi Medical Centre Makassar

    Directory of Open Access Journals (Sweden)

    Suharto Suharto

    2016-09-01

    Full Text Available AbstractFrozen shoulder is a condition where there is inflammation, pain, adhesions, atrophy and shortening the joint capsule of the shoulder joint, causing limitations. Attacks are usually unilateral, occurring more among women than men and it is more common in the age of 45-60 years. Frozen shoulder can affect the shoulder joint stiffness and functional inhibition of shoulder motion. The purpose of this study was to determine the influence of Hold relax technique to increase the distance of abducted motion of the frozen shoulder. This study was a quasy experiment with pretest-post test design. As many as 10 research subjects who experience frozen shoulder with limitation of motion of joint shoulder abduction who came for treatment to Physiotherapy Clinic of Ratulangi Medical Center from February to may 2014. The results showed a significant difference before and after administration of the hold relax technique with an average obtained by the difference value ROM of 10.80 + 3.150 with test results Wilcoxon p = 0.005. Conclusions: There was an addition of the shoulder joint abduction range of motion before and after the application of Hold-relax technique on frozen shoulder, so it is expected this technique can be used to overcome frozen shoulder.Keywords : Hold Relax, Range of motion, Frozen shoulderAbstrakFrozen shoulder adalah keadaan dimana terjadi peradangan, nyeri, perlengketan, atropi dan pemendekan kapsul sendi sehingga terjadi keterbatasan gerak sendi bahu. Serangan umumnya bersifat unilateral, lebih banyak pada wanita dibandingkan laki–laki dan lebih sering terjadi pada usia 45 – 60 tahun. Frozen shoulder dapat berdampak pada kekakuan dan terhambatnya fungsi gerak sendi bahu. Tujuan penelitian ini adalah untuk mengevaluasi pengaruh teknik hold relax terhadap penambahan jarak gerak abduksi sendi bahu frozen shoulder. Penelitian ini adalah quasi experimen dengan disain pretes–post tes. Subyek penelitian sebanyak 10 orang yang

  20. Water addition, evaporation and water holding capacity of poultry litter.

    Science.gov (United States)

    Dunlop, Mark W; Blackall, Patrick J; Stuetz, Richard M

    2015-12-15

    Litter moisture content has been related to ammonia, dust and odour emissions as well as bird health and welfare. Improved understanding of the water holding properties of poultry litter as well as water additions to litter and evaporation from litter will contribute to improved litter moisture management during the meat chicken grow-out. The purpose of this paper is to demonstrate how management and environmental conditions over the course of a grow-out affect the volume of water A) applied to litter, B) able to be stored in litter, and C) evaporated from litter on a daily basis. The same unit of measurement has been used to enable direct comparison-litres of water per square metre of poultry shed floor area, L/m(2), assuming a litter depth of 5cm. An equation was developed to estimate the amount of water added to litter from bird excretion and drinking spillage, which are sources of regular water application to the litter. Using this equation showed that water applied to litter from these sources changes over the course of a grow-out, and can be as much as 3.2L/m(2)/day. Over a 56day grow-out, the total quantity of water added to the litter was estimated to be 104L/m(2). Litter porosity, water holding capacity and water evaporation rates from litter were measured experimentally. Litter porosity decreased and water holding capacity increased over the course of a grow-out due to manure addition. Water evaporation rates at 25°C and 50% relative humidity ranged from 0.5 to 10L/m(2)/day. Evaporation rates increased with litter moisture content and air speed. Maintaining dry litter at the peak of a grow-out is likely to be challenging because evaporation rates from dry litter may be insufficient to remove the quantity of water added to the litter on a daily basis.

  1. Voltage holding optimization of the MITICA electrostatic accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Pilan, N., E-mail: nicola.pilan@igi.cnr.it [Consorzio RFX, Associazione EURATOM-ENEA sulla Fusione, Corso Stati Uniti 4, I-35127 Padova (Italy); Bettini, P. [Consorzio RFX, Associazione EURATOM-ENEA sulla Fusione, Corso Stati Uniti 4, I-35127 Padova (Italy); DII, Università di Padova, v. Gradenigo 6/A, I-35131 Padova (Italy); De Lorenzi, A. [Consorzio RFX, Associazione EURATOM-ENEA sulla Fusione, Corso Stati Uniti 4, I-35127 Padova (Italy); Specogna, R. [DIEGM, Università di Udine, v. delle Scienze 208, I-33100 Udine (Italy)

    2013-10-15

    Highlights: ► A set of electrostatic analyses of the region surrounding the MITICA electrostatic accelerator has been carried out. ► The distribution of the breakdown probability of the system has been calculated. ► The analyses have allowed identifying the weak point of the system to address the future design optimizations. -- Abstract: Two Heating Neutral Beam Injectors (H-NBI) are planned to be installed in ITER with a total delivered heating power of 33 MW [1]. The main parameters are: 870 kV acceleration voltage with 46 A beam current for hydrogen beam, and 1 MV voltage with 40 A current for deuterium beam. The voltage holding in the 1 MV ITER Neutral Beam Accelerator is recognized to be one of the most critical issues for long pulse (3600 s) beam operation, due to the complex electrostatic structure formed by electrodes polarized at different potentials immersed in vacuum or low-pressure gas. As a matter of fact, the system shall work in a p × d range at the left of the Paschen curve where the classical Townsend breakdown criterion is no longer valid. The voltage holding is governed by the mechanism of the long gap insulation in high vacuum, not yet well consolidated from the physical point of view. This paper is aimed to describe the optimization of the voltage holding capability for MITICA electrostatic accelerator. The results of this analysis will constitute the input for the probabilistic model [3] which is adopted to predict the breakdown probability by means of 2D analyses of the multi electrode – multi voltage system.

  2. Cognitive-motor interference while grasping, lifting and holding objects.

    Directory of Open Access Journals (Sweden)

    Erwan Guillery

    Full Text Available In daily life, object manipulation is usually performed concurrently to the execution of cognitive tasks. The aim of the present study was to determine which aspects of precision grip require cognitive resources using a motor-cognitive dual-task paradigm. Eighteen healthy participants took part in the experiment, which comprised two conditions. In the first condition, participants performed a motor task without any concomitant cognitive task. They were instructed to grip, lift and hold an apparatus incorporating strain gauges allowing a continuous measurement of the force perpendicular to each contact surface (grip force, GF as well as the total tangential force applied on the object (load force, LF. In the second condition, participants performed the same motor task while concurrently performing a cognitive task consisting in a complex visual search combined with counting. In the dual-task condition, we found a significant increase in the duration of the preload phase (time between initial contact of the fingers with the apparatus and onset of the load force, as well as a significant increase of the grip force during the holding phase, indicating that the cognitive task interfered with the initial force scaling performed during the preload phase and the fine-tuning of grip force during the hold phase. These findings indicate that these aspects of precision grip require cognitive resources. In contrast, other aspects of the precision grip, such as the temporal coupling between grip and load forces, were not affected by the cognitive task, suggesting that they reflect more automatic processes. Taken together, our results suggest that assessing the dynamic and temporal parameters of precision grip in the context of a concurrent cognitive task may constitute a more ecological and better-suited tool to characterize motor dysfunction in patients.

  3. Deep inspiration breath-hold radiotherapy for lung cancer

    DEFF Research Database (Denmark)

    Josipovic, Mirjana; Persson, Gitte F; Bangsgaard, Jens P

    2016-01-01

    OBJECTIVE: We investigated the impact of deep inspiration breath-hold (DIBH) and tumour baseline shifts on image quality and registration uncertainty in image-guided DIBH radiotherapy (RT) for locally advanced lung cancer. METHODS: Patients treated with daily cone beam CT (CBCT)-guided free...... ≤2 mm did not affect the CBCT image quality considerably. CONCLUSION: DIBH CBCT improved image quality and reduced registration uncertainty in the craniocaudal direction in image-guided RT of locally advanced lung cancer. Baseline shifts ≤2 mm in DIBH during CBCT acquisition did not affect image...

  4. Henan Non-ferrous Holding Company Set Up in Henan

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    <正>Henan Non-ferrous Holding Co.(hereinafter referred to as Henan Non-ferrous),an enterprise set up under the joint effort of 3 enterprises with state-owned assets namely Shenhuo Group,Yichuan Power and Yulian Group,has started its operation under tight schedule.The focus of the current operation is acquisition,for which a number of alumina and aluminum processing enterprises are on the list of Henan Non-ferrous.China Nonferrous Metals Monthly reported this news at our last issue,now we try to analysis more details behind the decision.

  5. Energy cost and optimisation in breath-hold diving.

    Science.gov (United States)

    Trassinelli, M

    2016-05-07

    We present a new model for calculating locomotion costs in breath-hold divers. Starting from basic mechanics principles, we calculate the work that the diver must provide through propulsion to counterbalance the action of drag, the buoyant force and weight during immersion. Compared to those in previous studies, the model presented here accurately analyses breath-hold divers which alternate active swimming with prolonged glides during the dive (as is the case in mammals). The energy cost of the dive is strongly dependent on these prolonged gliding phases. Here we investigate the length and impacts on energy cost of these glides with respect to the diver characteristics, and compare them with those observed in different breath-hold diving species. Taking into account the basal metabolic rate and chemical energy to propulsion transformation efficiency, we calculate optimal swim velocity and the corresponding total energy cost (including metabolic rate) and compare them with observations. Energy cost is minimised when the diver passes through neutral buoyancy conditions during the dive. This generally implies the presence of prolonged gliding phases in both ascent and descent, where the buoyancy (varying with depth) is best used against the drag, reducing energy cost. This is in agreement with past results (Miller et al., 2012; Sato et al., 2013) where, when the buoyant force is considered constant during the dive, the energy cost was minimised for neutral buoyancy. In particular, our model confirms the good physical adaption of dolphins for diving, compared to other breath-hold diving species which are mostly positively buoyant (penguins for example). The presence of prolonged glides implies a non-trivial dependency of optimal speed on maximal depth of the dive. This extends previous findings (Sato et al., 2010; Watanabe et al., 2011) which found no dependency of optimal speed on dive depth for particular conditions. The energy cost of the dive can be further

  6. Cash Holdings and Leverage of German Listed Firms

    DEFF Research Database (Denmark)

    Rapp, Marc Steffen; Killi, Andreas Maximilian

    2016-01-01

    We examine cash holdings and leverage levels of German listed (non-financial and non-utility) firms. We document a secular increase in cash ratios over the last twenty years (1992–2011), reducing the net debt book leverage ratio for the average sample firm close to zero. Using prediction models...... firms are associated with measures of uncertainty faced by firms. Our results suggest that German firms have increased (reduced) their cash (net debt leverage) levels over time in order to adopt more precautionary financial policies....

  7. La Holding Estrategia Fiscal Para las Empresas Familiares

    OpenAIRE

    Rosa Hilda Hernandez Sandoval; Sandra Patricia de la Garza Cienfuegos; Laura Leticia Gaona Tamez

    2010-01-01

    La presente investigación se realizó en Monclova, Coah., en el año 2011 y tiene por objeto constituir una empresa holding para obtener beneficios fiscales sin caer en la evasión o elusión fiscal, esta alternativa permite controlar desde la cúspide a las demás empresas subsidiarias que han sido creadas. Los resultados muestran que existen en México 4,862 empresas familiares que consolidan para efectos fiscales, las cuales se encuentran integradas en 422 grupos. En este régimen de fiscalización...

  8. Public Utility Holding Company Act of 1935: 1935--1992

    Energy Technology Data Exchange (ETDEWEB)

    1993-01-15

    This report provides an economic and legislative history and analysis of the Public Utilities Holding Company Act (PUHCA) of 1935. This Act was substantially amended for the first time in 1992 by passage of the Energy Policy Act (EPACT). The report also includes a discussion of the issues which led to the amendment of PUHCA and projections of the impact of these changes on the electric industry. The report should be of use to Federal and State regulators, trade associations, electric utilities, independent power producers, as well as decision-makers in Congress and the Administration.

  9. The Design of Reactor Internals Hold-Down Spring

    Directory of Open Access Journals (Sweden)

    Guohong Xue

    2016-01-01

    Full Text Available Hold down spring(HDS, clamped between the upper support plate flange and the core barrel flange inside a pressurized reactor vessel, is used to provide a downward force to keep the core barrel stable and from being lifted off from the vessel ledge during reactor normal operation. Spring designer used to think under certain extreme operating conditions, the spring could be lifted off from the ledge because the spring is not stiff enough to prevent the “lift-off”. Therefore, the spring was designed as stiff as it practically can be. However, finite element study indicated that the magnitude of preload is a strong function of friction coefficient. To find the magnitude of the friction coefficient, a series of tests were conducted on 1/10 scale hold down spring samples of three different spring designs. From the test results, it was found that the friction coefficient increases rapidly as the number of loading cycles increases. This implies that the spring preload would increase rapidly during plant operation. Therefore, it is concluded that, because of the strong frictional effect, not only the current design is more than adequate, but also should be made even softer.

  10. A Haptic Guided Robotic System for Endoscope Positioning and Holding.

    Science.gov (United States)

    Cabuk, Burak; Ceylan, Savas; Anik, Ihsan; Tugasaygi, Mehtap; Kizir, Selcuk

    2015-01-01

    To determine the feasibility, advantages, and disadvantages of using a robot for holding and maneuvering the endoscope in transnasal transsphenoidal surgery. The system used in this study was a Stewart Platform based robotic system that was developed by Kocaeli University Department of Mechatronics Engineering for positioning and holding of endoscope. After the first use on an artificial head model, the system was used on six fresh postmortem bodies that were provided by the Morgue Specialization Department of the Forensic Medicine Institute (Istanbul, Turkey). The setup required for robotic system was easy, the time for registration procedure and setup of the robot takes 15 minutes. The resistance was felt on haptic arm in case of contact or friction with adjacent tissues. The adaptation process was shorter with the mouse to manipulate the endoscope. The endoscopic transsphenoidal approach was achieved with the robotic system. The endoscope was guided to the sphenoid ostium with the help of the robotic arm. This robotic system can be used in endoscopic transsphenoidal surgery as an endoscope positioner and holder. The robot is able to change the position easily with the help of an assistant and prevents tremor, and provides a better field of vision for work.

  11. In which Financial Markets do Mutual Fund Theorems hold true?

    CERN Document Server

    Schachermayer, Walter; Taflin, Erik

    2007-01-01

    The Mutual Fund Theorem (MFT) is considered in a general semimartingale financial market S with a finite time horizon T, where agents maximize expected utility of terminal wealth. It is established that: 1) Let N be the wealth process of the num\\'eraire portfolio (i.e. the optimal portfolio for the log utility). If any path-independent option with maturity T written on the num\\'eraire portfolio can be replicated by trading \\emph{only} in N, then the (MFT) holds true for general utility functions, and the num\\'eraire portfolio may serve as mutual fund. This generalizes Merton's classical result on Black-Scholes markets. Conversely, under a supplementary weak completeness assumption, we show that the validity of the (MFT) for general utility functions implies the same replicability property for options on the num\\'eraire portfolio described above. 2) If for a given class of utility functions (i.e. investors) the (MFT) holds true in all complete Brownian financial markets S, then all investors use the same utili...

  12. Functional stability limits while holding loads in various positions.

    Science.gov (United States)

    Holbein, M A; Redfern, M S

    1997-05-01

    Stability of the body during manual material handling is an important issue in the prevention of falls and over-exertion injuries. This research investigated stability limits while standing and holding loads in different positions relative to the body. Theoretically, the stability region is the full base of support defined by the perimeter of the foot contact area. However, the functional stability region may be smaller. The purpose of this study was to locate functional stability limits with respect to the base of support. Fifteen male subjects leaned as far as possible in four directions in the sagittal and frontal planes. Their center of gravity location at these extremes determined the stability limit. The results showed that functional stability limits reached only about 60% of the distance to the maximum base of support limits under the conditions of this study. The sway angles reached at the stability limits averaged 9.2 degrees anteroposteriorly and 15.3 degrees laterally. External load positions which lowered the center of gravity of the body-and-load system extended those stability limits. This study provides a postural stability perspective of load-holding which may be applied in establishing safe lifting and reach limits.

  13. U.S. Army Military Surface Deployment and Distribution Command Needs to Improve its Oversight of Labor Detention Charges at Military Ocean Terminal Sunny Point

    Science.gov (United States)

    2016-03-16

    and informs the public. Vision Our vision is to be a model oversight organization in the Federal Government by leading change, speaking truth, and...erroneously paid for contractor safety briefings as labor detention charges because the 596th Transportation Brigade (BDE) Contracting Officer’s...Officer, U.S. Transportation Command: • direct the 596th BDE COR to ensure that charges billed for safety briefings are in accordance with the

  14. Comprehensive Risk Assessments of MOD and MOI Financial Management Capacity Could Improve Oversight of Over $4 Billion in Direct Assistance Funding

    Science.gov (United States)

    2013-11-01

    financial auditors , according to CJ8 officials. Most of the military officers assigned to CJ8 are budget and acquisition specialists, rather than...trained auditors . According to CJ8 personnel, these officers must learn a new task and become familiar with the Afghan government budgeting, acquisition...Frequent staff rotations compound the challenges which lead to potential deficiencies in CJ8’s oversight capacity. • Need for Increased Security

  15. Results of Hg speciation testing on MCU strip effluent hold tank (SEHT) and decontaminated salt solution hold tank (DSSHT) materials

    Energy Technology Data Exchange (ETDEWEB)

    Bannochie, C. J. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-09-17

    The Savannah River National Laboratory (SRNL) was tasked with preparing and shipping samples for Hg speciation by Eurofins Frontier Global Sciences, Inc. in Seattle, WA on behalf of the Savannah River Remediation (SRR) Mercury Task Team.i,ii The tenth shipment of samples was designated to include Modular Caustic Side Solvent Extraction Unit (MCU) Strip Effluent Hold Tank (SEHT) and MCU Decontaminated Salt Solution Hold Tank (DSSHT) materials from processing Salt Batch 7b. The MCU SEHT (MCU-15-722) and DSSHT (MCU-15-709) samples were pulled on June 15, 2015. All MCU samples were received at SRNL on June 16, 2015. The DSSHT sample was moved the same day to refrigeration, while the SEHT sample was placed in the Shielded Cells. On July 9, 2015 it was opened and an aliquot diluted 1:100 with Eurofins deionized water and a portion of the diluted sample transferred to a Teflon® bottle prior to moving it to refrigeration that same day. All samples were kept in the dark and refrigerated until final dilutions were prepared for shipment to Eurofins.

  16. VA Health Care: Improved Monitoring Needed for Effective Oversight of Care for Women Veterans

    Science.gov (United States)

    2016-12-01

    Health Care Letter 1 Background 6 VHA Lacks Complete and Accurate Data on VAMC Compliance with Environment of Care Requirements for Women Veterans...of Care Requirements 40 Appendix IV Veterans Health Administration (VHA) Gynecologist Availability 44 Appendix V Veterans Affairs (VA) Clinics...Veterans Health Administration (VHA) Requirements Related to the Outpatient Environment of Care for Women Veterans, December 2015-March 2016 40 Table

  17. Dare to be different: transformational leadership may hold the key to reducing the nursing shortage.

    Science.gov (United States)

    Thyer, Genevieve L

    2003-03-01

    Health care leadership continues to run under a transactional style that may be causing nurses to leave the system. Nurses no longer wish to stay in the profession perhaps because they struggle ideologically with the system in which they work. However, nurses may hold the key to transforming health care and dragging it into the 21st century in terms of work practices and reform. This is because nurses are visionary, creative, involved in decision making at patient level and have gender based qualities, and communication strategies that the health care sector needs. In contrast to transaction leadership, transformational leadership and team development has a positive affect on communication and team building. The later style is ideologically suited to nurses and may ensure the future of nurses and nursing in the health care sector. The case study described in this paper was an actual working environment and one that I came across all too often as a registered nurse and clinical educator.

  18. Ten years of Dutch loss compensation regime for holding and financing companies

    NARCIS (Netherlands)

    Bobeldijk, A.C.P.; Braeken, B.

    2014-01-01

    Dutch holding and financing companies are subject to a specific tax loss compensation regime, the so-called holding company loss rule. In short, the purpose of this rule is the prevention of the compensation of losses resulting from holding and financing activities with profits from operational acti

  19. 26 CFR 53.4943-2 - Imposition of tax on excess business holdings of private foundations.

    Science.gov (United States)

    2010-04-01

    ... foundation described in section 4946(a)(1)(H), a questionnaire asking such persons to list all holdings... constructively held by F. The questionnaire asks each such person to list the holdings in such enterprises of any... his family, had an interest). The questionnaire asks that constructive holdings be listed only...

  20. 17 CFR 450.3 - Exemption for holdings subject to fiduciary standards.

    Science.gov (United States)

    2010-04-01

    ... TREASURY REGULATIONS UNDER TITLE II OF THE GOVERNMENT SECURITIES ACT OF 1986 CUSTODIAL HOLDINGS OF GOVERNMENT SECURITIES BY DEPOSITORY INSTITUTIONS § 450.3 Exemption for holdings subject to fiduciary... the Office of Thrift Supervision governing the holding of government securities in a...

  1. Measurement of Gas Hold-up Profiles in Stirred Tank Reactors by Gamma Ray Attenuation Technique

    NARCIS (Netherlands)

    Parasu Veera, U.; Patwardhan, A.W.; Joshi, J.B.

    2001-01-01

    Gas hold-up is one of the most important hydrodynamic characteristics that is needed for performance estimation, design and scale-up of reactors. The performance of large-scale reactors can be reliably evaluated by measuring the gas hold-up in such reactors. In the present work, local gas hold-up in

  2. 26 CFR 1.556-3 - Illustration of computation of undistributed foreign personal holding company income.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Illustration of computation of undistributed foreign personal holding company income. 1.556-3 Section 1.556-3 Internal Revenue INTERNAL REVENUE SERVICE... Holding Companies § 1.556-3 Illustration of computation of undistributed foreign personal holding...

  3. 21 CFR 111.465 - What requirements apply to holding reserve samples of dietary supplements?

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false What requirements apply to holding reserve samples... Distributing § 111.465 What requirements apply to holding reserve samples of dietary supplements? (a) You must hold reserve samples of dietary supplements in a manner that protects against contamination...

  4. 12 CFR 225.122 - Bank holding company ownership of mortgage companies.

    Science.gov (United States)

    2010-01-01

    ...) Regulations Financial Holding Companies Interpretations § 225.122 Bank holding company ownership of mortgage... Federal law or (2) as comprised within the concept of “such incidental powers as shall be necessary to... section 4 of the Act is to confine a bank holding company's activities to the management and control of...

  5. 78 FR 17155 - Standards for the Growing, Harvesting, Packing, and Holding of Produce for Human Consumption...

    Science.gov (United States)

    2013-03-20

    ... Growing, Harvesting, Packing, and Holding of Produce for Human Consumption; Correction AGENCY: Food and..., harvesting, packing, and holding of produce, meaning fruits and vegetables grown for human consumption. FDA..., Harvesting, Packing, and Holding of Produce for Human Consumption.'' The document published with several...

  6. 78 FR 24692 - Standards for the Growing, Harvesting, Packing, and Holding of Produce for Human Consumption...

    Science.gov (United States)

    2013-04-26

    ... Growing, Harvesting, Packing, and Holding of Produce for Human Consumption; Extension of Comment Periods..., Harvesting, Packing, and Holding of Produce for Human Consumption'' that appeared in the Federal Register of... Growing, Harvesting, Packing, and Holding of Produce for Human Consumption'' with a 120-day comment period...

  7. 26 CFR 301.6501(f)-1 - Personal holding company tax.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Personal holding company tax. 301.6501(f)-1... Collection § 301.6501(f)-1 Personal holding company tax. If a corporation which is a personal holding company... time during the last half of such taxable year, more than 50 percent in value of the...

  8. 76 FR 79190 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2011-12-21

    ..., California 94105-1579: 1. Private Bancorp of America, Inc., La Jolla, California; to become a bank holding... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C...

  9. 26 CFR 1.897-2 - United States real property holding corporations.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false United States real property holding corporations... property holding corporations. (a) Purpose and scope. This section provides rules regarding the definition and consequences of U.S. real property holding corporation status. U.S. real property...

  10. 12 CFR 574.8 - Qualified stock issuances by undercapitalized savings associations or holding companies.

    Science.gov (United States)

    2010-01-01

    ... stock by the acquiring savings and loan holding company. (5) The entire consideration for the stock issued is paid in cash by the acquiring savings and loan holding company. (6) At the time of the stock issuance, each savings association subsidiary of the acquiring savings and loan holding company (other...

  11. 46 CFR 154.1210 - Hold space, void space, cofferdam, and spaces containing cargo piping.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Hold space, void space, cofferdam, and spaces containing... Design, Construction and Equipment Cargo Area: Mechanical Ventilation System § 154.1210 Hold space, void space, cofferdam, and spaces containing cargo piping. (a) Each hold space, void space, cofferdam,...

  12. China will Hold Seminar to Greet the World Standards Day

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ Here comes 2004, the 35th session of the World Standards Day. The theme of this session is"Standards Connect the World", which is precisely a good turning point not only for the domestic economy to connect rails gradually with international, but also for national government to consummate and strengthen the standardization management system, to advance standardization work, and to raise the standardization level, after China's entrance into the World Trade Organization. Therefore, when the 35th session of the World Standards Day is arriving, sponsored by the SAC (Standardization Administration of China) and organized by CAS (China Association for Standardization), China will hold a seminar on October 14 in the Great Hall of the People.

  13. DOES UNCOVERED INTEREST RATE PARITY HOLD IN TURKEY?

    Directory of Open Access Journals (Sweden)

    Ozcan Karahan

    2012-01-01

    Full Text Available Most of the earlier empirical studies focusing on developed countries failed to give evidence in favor of the Uncovered Interest Rate Parity (UIP. After intensive financial liberalization processes and mostly preferred free exchange rate regimes, a new area of research starts to involve the investigation whether UIP holds for developing economies differently. Accordingly, we tested the UIP for Turkey’s monthly interest rate and exchange rate data between 2002 and 2011. We run conventional regressions in the form of Ordinary Least Squares (OLS and used a simple Generalized Autoregressive Conditional Heteroskedasticity (GARCH analysis. The empirical results of both methods do not support the validity of UIP for Turkey. Thus, together with most of the earlier empirical studies focusing on developed countries and detecting the invalidity of UIP, we can argue that the experience of Turkey and developed economies are not different.

  14. Experimental determination of bone cortex holding power of orthopedic screw

    Directory of Open Access Journals (Sweden)

    Bolliger Neto Raul

    1999-01-01

    Full Text Available Cylindrical specimens of bone measuring 15 mm in diameter were obtained from the lateral cortical layer of 10 pairs of femurs and tibias. A central hole 3.2 mm in diameter was drilled in each specimen. The hole was tapped, and a 4.5 mm cortical bone screw was inserted from the outer surface. The montage was submitted to push-out testing up to a complete strip of the bone threads. The cortical thickness and rupture load were measured, and the shear stress was calculated. The results were grouped according to the bone segment from which the specimen was obtained. The results showed that bone cortex screw holding power is dependent on the bone site. Additionally, the diaphyseal cortical bone tissue is both quantitatively and qualitatively more resistant to screw extraction than the metaphyseal tissue.

  15. Animal Research, the 3Rs, and the "Internet of Things": Opportunities and Oversight in International Pharmaceutical Development.

    Science.gov (United States)

    Niemi, Steven M; Davies, Gail F

    2016-12-01

    Stages of drug (and vaccine) discovery and evaluation that involve laboratory animals increasingly occur via scientific collaborations across national borders and continents. Many of these research collaborations are between asset-rich institutions and others in less wealthy parts of the world. The care and use of laboratory animals in geographically disparate locations introduces new complexities, such as different oversight requirements and available resources, as well as diverse organizational and cultural milieus. These complexities can hamper the effectiveness of local animal welfare committees and regulatory compliance, as well as compromise good science and animal welfare. At the same time, new technologies are becoming available that offer greater transparency in how these collaborations and their animal subjects are faring in real time that, in turn, can enable progress towards the 3 Rs. The focus of this essay is to identify potential rewards and risks stemming from new techniques for producing and connecting data in preclinical pharmaceutical development and consider how further social scientific investigations have the potential to enhance the benefits of international research collaborations for both human health and animal welfare.

  16. Promoting Healthy Growth or Feeding Obesity? The Need for Evidence-Based Oversight of Infant Nutritional Supplement Claims

    Directory of Open Access Journals (Sweden)

    Michelle Lampl

    2016-11-01

    Full Text Available The Developmental Origins of Health and Disease (DOHaD model recognizes growth in infancy and childhood as a fundamental determinant of lifespan health. Evidence of long-term health risks among small neonates who subsequently grow rapidly poses a challenge for interventions aiming to support healthy growth, not merely drive weight gain. Defining healthy growth beyond “getting bigger” is essential as infant and young child feeding industries expand. Liquid-based nutritional supplements, originally formulated for undernourished children, are increasingly marketed for and consumed by children generally. Clarifying the nature of the evidentiary base on which structure/function claims promoting “healthy growth” are constructed is important to curb invalid generalizations. Evidence points to changing social beliefs and cultural practices surrounding supplementary feeding, raising specific concerns about the long-term health consequences of an associated altered feeding culture, including reduced dietary variety and weight gain. Reassessing the evidence for and relevance of dietary supplements’ “promoting healthy growth” claims for otherwise healthy children is both needed in a time of global obesity and an opportunity to refine intervention approaches among small children for whom rapid subsequent growth in early life augments risk for chronic disease. Scientific and health care partnerships are needed to consider current governmental oversight shortfalls in protecting vulnerable populations from overconsumption. This is important because we may be doing more harm than good.

  17. Promoting Healthy Growth or Feeding Obesity? The Need for Evidence-Based Oversight of Infant Nutritional Supplement Claims

    Science.gov (United States)

    Lampl, Michelle; Mummert, Amanda; Schoen, Meriah

    2016-01-01

    The Developmental Origins of Health and Disease (DOHaD) model recognizes growth in infancy and childhood as a fundamental determinant of lifespan health. Evidence of long-term health risks among small neonates who subsequently grow rapidly poses a challenge for interventions aiming to support healthy growth, not merely drive weight gain. Defining healthy growth beyond “getting bigger” is essential as infant and young child feeding industries expand. Liquid-based nutritional supplements, originally formulated for undernourished children, are increasingly marketed for and consumed by children generally. Clarifying the nature of the evidentiary base on which structure/function claims promoting “healthy growth” are constructed is important to curb invalid generalizations. Evidence points to changing social beliefs and cultural practices surrounding supplementary feeding, raising specific concerns about the long-term health consequences of an associated altered feeding culture, including reduced dietary variety and weight gain. Reassessing the evidence for and relevance of dietary supplements’ “promoting healthy growth” claims for otherwise healthy children is both needed in a time of global obesity and an opportunity to refine intervention approaches among small children for whom rapid subsequent growth in early life augments risk for chronic disease. Scientific and health care partnerships are needed to consider current governmental oversight shortfalls in protecting vulnerable populations from overconsumption. This is important because we may be doing more harm than good. PMID:27845744

  18. How can nanobiotechnology oversight advance science and industry: examples from environmental, health, and safety studies of nanoparticles (nano-EHS)

    Science.gov (United States)

    Wang, Jing; Asbach, Christof; Fissan, Heinz; Hülser, Tim; Kuhlbusch, Thomas A. J.; Thompson, Drew; Pui, David Y. H.

    2011-04-01

    Nanotechnology has great potential to transform science and industry in the fields of energy, material, environment, and medicine. At the same time, more concerns are being raised about the occupational health and safety of nanomaterials in the workplace and the implications of nanotechnology on the environment and living systems. Studies on environmental, health, and safety (EHS) issues of nanomaterials have a strong influence on public acceptance of nanotechnology and, eventually, affect its sustainability. Oversight and regulation by government agencies and non-governmental organizations (NGOs) play significant roles in ensuring responsible and environmentally friendly development of nanotechnology. The EHS studies of nanomaterials can provide data and information to help the development of regulations and guidelines. We present research results on three aspects of EHS studies: physico-chemical characterization and measurement of nanomaterials; emission, exposure, and toxicity of nanomaterials; and control and abatement of nanomaterial releases using filtration technology. Measurement of nanoparticle agglomerates using a newly developed instrument, the Universal NanoParticle Analyzer (UNPA), is discussed. Exposure measurement results for silicon nanoparticles in a pilot scale production plant are presented, as well as exposure measurement and toxicity study of carbon nanotubes (CNTs). Filtration studies of nanoparticle agglomerates are also presented as an example of emission control methods.

  19. International stem cell tourism and the need for effective regulation. Part II: Developing sound oversight measures and effective patient support.

    Science.gov (United States)

    Cohen, Cynthia B; Cohen, Peter J

    2010-09-01

    Part I of this article, published in the March 2010 issue of the Kennedy Institute of Ethics Journal, traces and addresses the provision of unproven stem cell treatments in Russia and India, examines the concept of innovative treatment, and concludes that stronger regulations are needed to protect the health and informed choices of patients. The current paper, Part II, proposes that the regulatory frameworks for the development of safe and efficacious treatments in effect in the United States and the United Kingdom provide examples of strong oversight measures from which countries seeking to obtain international credibility for their biotechnological competence could draw when developing regulations for stem cell treatments. Major sources of information available to persons who consider receiving such unproven treatments are explored in order to understand and address their concerns. The paper concludes with proposed measures to inform those considering the pursuit of unproven stem cell treatments abroad more accurately about their efficacy and safety and provide them with improved medical and social support in their home countries.

  20. 12 CFR 502.26 - How does OTS calculate the semi-annual assessment for savings and loan holding companies?

    Science.gov (United States)

    2010-01-01

    ...-site supervision of a noncomplex, low risk savings and loan holding company structure. OTS will... company is the registered holding company at the highest level of ownership in a holding company structure, unless OTS designates another savings and loan holding company in the holding company structure. OTS...

  1. Phase-Type Models of Channel-Holding Times in Cellular Communication Systems

    DEFF Research Database (Denmark)

    Christensen, Thomas Kaare; Nielsen, Bo Friis; Iversen, Villy Bæk

    2004-01-01

    In this paper, we derive the distribution of the channel-holding time when both cell-residence and call-holding times are phase-type distributed. Furthermore, the distribution of the number of handovers, the conditional channel-holding time distributions, and the channel-holding time when cell re...... residence times are correlated are derived. All distributions are of phase type, making them very general and flexible. The channel-holding times are of importance in performance evaluation and simulation of cellular mobile communication systems....

  2. Financial claims and product market competition: An explanation for permitting banks to hold equity in firms

    Directory of Open Access Journals (Sweden)

    Pao Shin-Heng

    2008-01-01

    Full Text Available This paper examines financial claims for lending if banks are permitted to hold equity in productive firms. We demonstrate that in situations where an oligopolistic product market has relatively high competition, e.g., quasi-competitive behavior, equity holding by banks is likely to do little damage. However, where the product market has relatively high collusion, e.g., corporative behavior, equity holding by banks are very unlikely to hold equity in firms. Our findings provide an alternative argument that lifting the Glass-Steagall Act restricting banks from holding equity in firms should give little cause for concern.

  3. Robustness of the Voluntary Breath-Hold Approach for the Treatment of Peripheral Lung Tumors Using Hypofractionated Pencil Beam Scanning Proton Therapy

    DEFF Research Database (Denmark)

    Dueck, Jenny; Knopf, Antje-Christin; Lomax, Antony

    2016-01-01

    PURPOSE: The safe clinical implementation of pencil beam scanning (PBS) proton therapy for lung tumors is complicated by the delivery uncertainties caused by breathing motion. The purpose of this feasibility study was to investigate whether a voluntary breath-hold technique could limit the delivery...

  4. [The use of Pantogam syrup in treating small children's breath holding spells].

    Science.gov (United States)

    Polskaya, A V; Chutko, L S; Jakovenko, E V

    To study the efficacy of pantogam syrup 10% (hopantenic acid) in the treatment of breath-holding spells (BHS). Sixty children, aged from 2 to 4 years, with BHS were studied. The evaluation of clinical manifestations and anxiety level was performed. Results of neurophysiological examination (long-term video-EEG-monitoring) were analyzed. Children were divided into 2 groups: main, in which the patients received pantogam syrup, and control group, in which only psychological methods were used. The results of the clinical and neurophysiological studies performed after the treatment, showed the clinical improvement in 73.3% of patients of the main group compared with similar data from the children in the control group (16.7%). The anxiety level significantly decreased after the neuroprotective therapy. A comparative analysis of electroencephalographic indicators demonstrated a significant (рrhythms and manifestations of functional immaturity of the brain in patients of the main group. These results give evidence for the high efficacy of pantogam syrup in the treatment of children with BHS.

  5. Maximum holding endurance time: Effects of load and load's center of gravity height.

    Science.gov (United States)

    Lee, Tzu-Hsien

    2015-01-01

    Manual holding task is a potential risk to the development of musculoskeletal injuries since it is prone to induce localized muscle fatigue. Maximum holding endurance time is a significant parameter for the design of manual holding task. This study aimed to examine the effects of load and load's COG height on maximum holding endurance time. Fifteen young and healthy males were recruited as participants. A factorial design was used to examine the effects of load and load's COG height on maximum holding endurance time. Four levels of load (15% , 30% , 45% and 60% of the participant's maximum holding capacity) and two levels of load's COG height in box (0 cm and 40 cm high from the handle position) were examined. Maximum holding endurance time decreased with increasing load and/or increasing load's COG height. The effect of load's COG height on maximum holding endurance time decreased with increasing load. Load, load's COG height, and the interaction of load and load's COG height significantly affected maximum holding endurance time. Practitioners should realize the effects of load, load's COG height, and the interaction of load and load's COG height on maximum holding endurance time when setting the working conditions of holding tasks.

  6. Quantifying the risk of nosocomial infection within Ebola Holding Units: a retrospective cohort study of negative patients discharged from five Ebola Holding Units in Western Area, Sierra Leone.

    Science.gov (United States)

    Arkell, Paul; Youkee, Daniel; Brown, Colin S; Kamara, Abdul; Kamara, Thaim B; Johnson, Oliver; Lado, Marta; George, Viginia; Koroma, Fatmata; King, Matilda B; Parker, Benson E; Baker, Peter

    2017-01-01

    A central pillar in the response to the 2014 Ebola virus disease (EVD) epidemic in Sierra Leone was the role of Ebola Holding Units (EHUs). These units isolated patients meeting a suspect case definition, tested them for EVD, initiated appropriate early treatment and discharged negative patients to onward inpatient care or home. Positive patients were referred to Ebola Treatment Centres. We aimed to estimate the risk of nosocomial transmission within these EHUs. We followed up a cohort of 543 patients discharged with a negative EVD test from five EHUs in the Western Area, Sierra Leone, and examined all line-listed subsequent EVD tests from any facility in the Western Area to see whether the patient was retested within 30 days, matching by name, age and address. We defined possible readmissions as having the same name and age but uncertain address, and confirmed readmissions where name, age and address matched. We found a positive readmission rate of 3.3% (18 cases), which included 1.5% confirmed readmissions (8 cases) and 1.8% possible readmissions (10 cases). This is lower than rates previously reported. We cannot ascertain whether EVD was acquired within the EHUs or from re-exposure in the community. No demographic or clinical variables were identified as risk factors for positive readmission, likely due to our small sample size. These findings support the EHU model as a safe method for isolation of suspect EVD patients and their role in limiting the spread of EVD. © 2016 John Wiley & Sons Ltd.

  7. Does EVA performance evaluation improve the value of cash holdings? Evidence from China

    Institute of Scientific and Technical Information of China (English)

    Yongjian; Shen; Lei; Zou; Donghua; Chen

    2015-01-01

    This paper investigates the influence of the economic value added(EVA)performance evaluation,issued in 2010 by the State-owned Assets Supervision and Administration Commission of the State Council,on the value of the cash holdings of central state-owned enterprises(CSOEs).We find that EVA performance evaluation has some influence on the overinvestment of CSOE cash holdings and significantly increases the value of CSOE cash holdings compared with the cash holdings of local state-owned enterprises.The greater value of CSOE cash holdings derives from underinvestment modification and overinvestment restraint.The value of cash holdings increases more for companies with better accounting performance.Thus,the EVA performance evaluation policy increases CSOE efficiency.This study contributes to the emerging literature related to cash holdings and the economic consequences of the EVA performance evaluation policy.It expands the literature related to investor protection in countries experiencing economic transition.

  8. Does EVA performance evaluation improve the value of cash holdings? Evidence from China

    Directory of Open Access Journals (Sweden)

    Yongjian Shen

    2015-09-01

    Full Text Available This paper investigates the influence of the economic value added (EVA performance evaluation, issued in 2010 by the State-owned Assets Supervision and Administration Commission of the State Council, on the value of the cash holdings of central state-owned enterprises (CSOEs. We find that EVA performance evaluation has some influence on the overinvestment of CSOE cash holdings and significantly increases the value of CSOE cash holdings compared with the cash holdings of local state-owned enterprises. The greater value of CSOE cash holdings derives from underinvestment modification and overinvestment restraint. The value of cash holdings increases more for companies with better accounting performance. Thus, the EVA performance evaluation policy increases CSOE efficiency. This study contributes to the emerging literature related to cash holdings and the economic consequences of the EVA performance evaluation policy. It expands the literature related to investor protection in countries experiencing economic transition.

  9. ENVIRONMENTAL SUSTAINABILITY OF FAMILY-OWNED AGRICULTURAL HOLDINGS IN THE PODLASKIE VOIVODESHIP

    Directory of Open Access Journals (Sweden)

    Zofia Kołoszko-Chomentowska

    2015-09-01

    Full Text Available The subject of this paper is environmental sustainability assessment of agricultural holdings in the Podlaskie voivodeship, participating in the Farm Accountancy Data Network (FADN in the years 2007–2012. The assessment was conducted based on agro-ecological indicators and environmental burden (material pressure. The analysis was conducted according to a classification into agricultural holding types: field crops, dairy cattle, and mixed holdings. The factor with the strongest impact on the agro-ecological sustainability of the studied agricultural holdings was the holding type. Field crop and mixed holdings achieved more favorable environmental sustainability indicators. Holdings specializing in dairy cattle breeding pose a threat to the natural environment due to their excessive number of livestock.

  10. Digital pathology in clinical use: where are we now and what is holding us back?

    Science.gov (United States)

    Griffin, Jon; Treanor, Darren

    2017-01-01

    Whole slide imaging is being used increasingly in research applications and in frozen section, consultation and external quality assurance practice. Digital pathology, when integrated with other digital tools such as barcoding, specimen tracking and digital dictation, can be integrated into the histopathology workflow, from specimen accession to report sign-out. These elements can bring about improvements in the safety, quality and efficiency of a histopathology department. The present paper reviews the evidence for these benefits. We then discuss the challenges of implementing a fully digital pathology workflow, including the regulatory environment, validation of whole slide imaging and the evidence for the design of a digital pathology workstation.

  11. SU-E-J-62: Breath Hold for Left-Sided Breast Cancer: Visually Monitored Deep Inspiration Breath Hold Amplitude Evaluated Using Real-Time Position Management

    Energy Technology Data Exchange (ETDEWEB)

    Conroy, L; Quirk, S; Smith, WL [The University of Calgary, Calgary, AB (Canada); Tom Baker Cancer Centre, Calgary, AB (Canada); Yeung, R; Phan, T [The University of Calgary, Calgary, AB (Canada); Hudson, A [Tom Baker Cancer Centre, Calgary, AB (Canada)

    2015-06-15

    Purpose: We used Real-Time Position Management (RPM) to evaluate breath hold amplitude and variability when gating with a visually monitored deep inspiration breath hold technique (VM-DIBH) with retrospective cine image chest wall position verification. Methods: Ten patients with left-sided breast cancer were treated using VM-DIBH. Respiratory motion was passively collected once weekly using RPM with the marker block positioned at the xiphoid process. Cine images on the tangent medial field were acquired on fractions with RPM monitoring for retrospective verification of chest wall position during breath hold. The amplitude and duration of all breath holds on which treatment beams were delivered were extracted from the RPM traces. Breath hold position coverage was evaluated for symmetric RPM gating windows from ± 1 to 5 mm centered on the average breath hold amplitude of the first measured fraction as a baseline. Results: The average (range) breath hold amplitude and duration was 18 mm (3–36 mm) and 19 s (7–34 s). The average (range) of amplitude standard deviation per patient over all breath holds was 2.7 mm (1.2–5.7 mm). With the largest allowable RPM gating window (± 5 mm), 4 of 10 VM-DIBH patients would have had ≥ 10% of their breath hold positions excluded by RPM. Cine verification of the chest wall position during the medial tangent field showed that the chest wall was greater than 5 mm from the baseline in only 1 out of 4 excluded patients. Cine images verify the chest wall/breast position only, whether this variation is acceptable in terms of heart sparing is a subject of future investigation. Conclusion: VM-DIBH allows for greater breath hold amplitude variability than using a 5 mm gating window with RPM, while maintaining chest wall positioning accuracy within 5 mm for the majority of patients.

  12. Marketing Regulatory Oversight of Advanced Therapy Medicinal Products (ATMPs) in Europe: The EMA/CAT Perspective.

    Science.gov (United States)

    Salmikangas, Paula; Schuessler-Lenz, Martina; Ruiz, Sol; Celis, Patrick; Reischl, Ilona; Menezes-Ferreira, Margarida; Flory, Egbert; Renner, Matthias; Ferry, Nicolas

    2015-01-01

    With the release of Regulation 1394/2007, a new framework for gene and cell therapy medicinal products and tissue-engineered products was established in the European Union. For all three product classes, called advanced therapy medicinal products, a centralised marketing authorisation became mandatory. The European Medicines Agency (EMA) together with its Committee for Advanced Therapies, Committee for Human Medicinal Products and the network of national agencies is responsible for scientific evaluation of the marketing authorisation applications. For a new application, data and information relating to manufacturing processes and quality control of the active substance and the final product have to be submitted for evaluation together with data from non-clinical and clinical safety and efficacy studies. Technical requirements for ATMPs are defined in the legislation, and guidance for different products is available through several EMA/CAT guidelines. Due to the diversity of ATMPs, a tailored approach for regulating these products is considered necessary. Thus, a risk-based approach has been introduced for ATMPs allowing flexibility for the regulatory requirements. Since the regulatory framework for ATMPs was established, five products have been licenced in the European Union. However, the pipeline of new ATMPs is much bigger, as seen from the significant numbers of different products discussed by the CAT in scientific advice and classification procedures. In 2013, a public consultation on the ATMP Regulation was conducted by the European Commission, and the results were published in 2014. The report proposes several improvements for the current framework and established procedures for the regulation of ATMPs.

  13. Dual job holding practitioners in Bangladesh: an exploration.

    Science.gov (United States)

    Gruen, Reinhold; Anwar, Raqibul; Begum, Tahmina; Killingsworth, James R; Normand, Charles

    2002-01-01

    This paper analyses the system of financial and non-financial incentives underlying job preferences of doctors in Bangladesh who work both in government health services and in private practice. The study is based on a survey of 100 government-employed doctors with private practice, across different levels of care and geographical areas. In-depth interviews were carried out in a sub-sample of 28 respondents. The study explores the beliefs and attitudes towards the arrangements of joint private/public practice, establishes profiles of fee levels and earnings and examines the options to change the incentive system in a way that ensures an increased involvement of dual job holding practitioners in the priority areas of care. Consultation fees were Tk120 on average (range Tk20-300) and found to be correlated with the qualification of the practice owner and the type of service offered. A majority of the respondents reported at least to double their government income by engaging in private practice. Significant predictors of total income included the number of patients seen in private practice (p=0.000), employment in a secondary or tertiary care facility (p=0.001) and ownership of premises for private practice (p=0.033). Age was found to be marginally significant (p=0.084). No association was found between total income and specialisation, private practice costs, level of government salary or a degree from abroad. The data suggest that doctors have adopted individual strategies to accommodate the advantages of both government employment and private practice in their career development, thus maximising benefit from the incentives provided to them e.g. status of a government job, and minimising opportunity costs of economic losses e.g. lower salaries. Commitment to government services was found to be greater among doctors in primary health care who reported they would give up private practice if paid a higher salary. Among doctors in secondary and tertiary care, the

  14. Three-dimensional imaging of hold baggage for airport security

    Science.gov (United States)

    Kolokytha, S.; Speller, R.; Robson, S.

    2014-06-01

    This study describes a cost-effective check-in baggage screening system, based on "on-belt tomosynthesis" (ObT) and close-range photogrammetry, that is designed to address the limitations of the most common system used, conventional projection radiography. The latter's limitations can lead to loss of information and an increase in baggage handling time, as baggage is manually searched or screened with more advanced systems. This project proposes a system that overcomes such limitations creating a cost-effective automated pseudo-3D imaging system, by combining x-ray and optical imaging to form digital tomograms. Tomographic reconstruction requires a knowledge of the change in geometry between multiple x-ray views of a common object. This is uniquely achieved using a close range photogrammetric system based on a small network of web-cameras. This paper presents the recent developments of the ObT system and describes recent findings of the photogrammetric system implementation. Based on these positive results, future work on the advancement of the ObT system as a cost-effective pseudo-3D imaging of hold baggage for airport security is proposed.

  15. Antigen Loss Variants: Catching Hold of Escaping Foes

    Science.gov (United States)

    Vyas, Maulik; Müller, Rolf; Pogge von Strandmann, Elke

    2017-01-01

    Since mid-1990s, the field of cancer immunotherapy has seen steady growth and selected immunotherapies are now a routine and preferred therapeutic option of certain malignancies. Both active and passive cancer immunotherapies exploit the fact that tumor cells express specific antigens on the cell surface, thereby mounting an immune response specifically against malignant cells. It is well established that cancer cells typically lose surface antigens following natural or therapy-induced selective pressure and these antigen-loss variants are often the population that causes therapy-resistant relapse. CD19 and CD20 antigen loss in acute lymphocytic leukemia and chronic lymphocytic leukemia, respectively, and lineage switching in leukemia associated with mixed lineage leukemia (MLL) gene rearrangements are well-documented evidences in this regard. Although increasing number of novel immunotherapies are being developed, majority of these do not address the control of antigen loss variants. Here, we review the occurrence of antigen loss variants in leukemia and discuss the therapeutic strategies to tackle the same. We also present an approach of dual-targeting immunoligand effectively retargeting NK cells against antigen loss variants in MLL-associated leukemia. Novel immunotherapies simultaneously targeting more than one tumor antigen certainly hold promise to completely eradicate tumor and prevent therapy-resistant relapses. PMID:28286501

  16. Role of cerebral blood flow in extreme breath holding

    Directory of Open Access Journals (Sweden)

    Bain Anthony R.

    2016-01-01

    Full Text Available The role of cerebral blood flow (CBF on a maximal breath-hold (BH in ultra-elite divers was examined. Divers (n = 7 performed one control BH, and one BH following oral administration of the non-selective cyclooxygenase inhibitor indomethacin (1.2 mg/kg. Arterial blood gases and CBF were measured prior to (baseline, and at BH termination. Compared to control, indomethacin reduced baseline CBF and cerebral delivery of oxygen (CDO2 by about 26% (p < 0.01. Indomethacin reduced maximal BH time from 339 ± 51 to 319 ± 57 seconds (p = 0.04. In both conditions, the CDO2 remained unchanged from baseline to the termination of apnea. At BH termination, arterial oxygen tension was higher following oral administration of indomethacin compared to control (4.05 ± 0.45 vs. 3.44 ± 0.32 kPa. The absolute increase in CBF from baseline to the termination of apnea was lower with indomethacin (p = 0.01. These findings indicate that the impact of CBF on maximal BH time is likely attributable to its influence on cerebral H+ washout, and therefore central chemoreceptive drive to breathe, rather than to CDO2.

  17. Model reduction for experimental thermal characterization of a holding furnace

    Science.gov (United States)

    Loussouarn, Thomas; Maillet, Denis; Remy, Benjamin; Dan, Diane

    2017-09-01

    Vacuum holding induction furnaces are used for the manufacturing of turbine blades by loss wax foundry process. The control of solidification parameters is a key factor for the manufacturing of these parts. The definition of the structure of a reduced heat transfer model with experimental identification through an estimation of its parameters is required here. Internal sensors outputs, together with this model, can be used for assessing the thermal state of the furnace through an inverse approach, for a better control. Here, an axisymmetric furnace and its load have been numerically modelled using FlexPDE, a finite elements code. The internal induction heat source as well as the transient radiative transfer inside the furnace are calculated through this detailed model. A reduced lumped body model has been constructed to represent the numerical furnace. The model reduction and the estimation of the parameters of the lumped body have been made using a Levenberg-Marquardt least squares minimization algorithm, using two synthetic temperature signals with a further validation test.

  18. Holding-side influences on infant's view of mother's face.

    Science.gov (United States)

    Hendriks, Angélique W; van Rijswijk, Mariëlle; Omtzigt, David

    2011-11-01

    Recently we found that adult children whose mothers had had a right-arm preference for holding infants have a reduced left bias for recognising faces, suggesting that they are less well right-hemisphere lateralised for perceiving faces. One possible explanation of this finding is that early visual exposure to faces is suboptimal for right-held infants. To test this idea, we asked mothers to pick up a doll with an inbuilt camera in its face and to start bottle-feeding it. The results showed that less was visible of the face of mothers who held the doll on their right arm in comparison to those who held the doll on their left arm: From the right arm, the mother's left half of the face was less visible when the mothers were looking up and their right half of the face was less visible when they were looking at the doll. These results suggest that right-held infants receive suboptimal information from faces. Because early face exposure is important for face-processing development, the suboptimal face exposure probably experienced by right-held infants may have consequences for their ability to recognise faces and facial emotion later in life.

  19. Life on hold: the experience of living with neuromyelitis optica.

    Science.gov (United States)

    Mutch, Kerry; Methley, Abigail; Moore, Phil; Jacob, Anu

    2014-01-01

    Neuromyelitis optica (NMO) is a rare autoimmune condition characterised by acute relapses of optic neuritis and extensive transverse myelitis. The aim of this qualitative study was to develop an improved understanding of the experiences of people living with NMO. Fifteen participants completed a semi-structured interview and data were interpreted using a constant comparative method. Participants were recruited from the Northern UK NMO Service. Five major themes were identified: diagnosis and treatment, symptoms, adjustment, identity and support. Results suggest NMO is a difficult condition to live with due to the unpredictability of relapses and accrued disability of visual or spinal symptoms occurring with each relapse. Poor vision, reduced mobility, bladder dysfunction and pain affected participants' independence and experience of living with NMO. Participants reported that during relapse and recovery they would "put their life on hold". They identified the importance of periods of stability to enable them to adjust to their condition and therefore aim for "normality" of life that they believed was comparable to their peers. Implications for Rehabilitation Disability due to NMO has a major impact on an individual's life, abilities and identity. Timely treatment of relapse is essential to reduce or prevent disability. Health care professionals need to coordinate care locally and nationally. Multi-disciplinary work is vital to promote adjustment, coping strategies and support for people living with NMO.

  20. Generics Substitution, Bioequivalence Standards, and International Oversight: Complex Issues Facing the FDA.

    Science.gov (United States)

    Bate, Roger; Mathur, Aparna; Lever, Harry M; Thakur, Dinesh; Graedon, Joe; Cooperman, Tod; Mason, Preston; Fox, Erin R

    2016-03-01

    The regulations for assessing the quality of generic drugs and their bioequivalence to innovator products are outdated and need to be substantially modernized. There are multiple reasons why these changes are needed, including: (i) the regulations remain largely unchanged since the passage of the Hatch-Waxman Act in 1984; (ii) medication therapies have become substantially more complex over the three decades since the passage of the Act; (iii) a switch from an innovator drug to a generic drug, or switching from one generic to another, is not a benign process - there is substantial clinical professional judgment involved and in some instances these decisions should be better informed; and (iv) pharmaceutical ingredients for finished products, whether innovator or generic, are from multiple sources of supply, adding variability in their production, and which may not be accounted for in specification tolerances. When these elements are viewed together, they clearly suggest that more transparency of responsible manufacturers in product labels and updated standards for bioequivalence are required.

  1. The woman who could not hold up her head

    NARCIS (Netherlands)

    Muntinghe, FLH; Kuiper, MA

    2003-01-01

    Low serum potassium concentration is a frequently encountered abnormality, seldom accompanied by life-threatening symptoms. We present a 55-year-old women with a severe, symptomatic hypokalaemia. The pathogenesis and clinical manifestations are discussed.

  2. The woman who could not hold up her head

    NARCIS (Netherlands)

    Muntinghe, FLH; Kuiper, MA

    2003-01-01

    Low serum potassium concentration is a frequently encountered abnormality, seldom accompanied by life-threatening symptoms. We present a 55-year-old women with a severe, symptomatic hypokalaemia. The pathogenesis and clinical manifestations are discussed.

  3. Effects of Piracetam on Pediatric Breath Holding Spells: A Randomized Double Blind Controlled Trial

    Directory of Open Access Journals (Sweden)

    Mohammad Sadegh REZAI

    2012-10-01

    Full Text Available ObjectiveBreath holding spells (BHS are common paroxysmal non-epileptic events in the pediatric population which are very stressful despite their harmless nature. There has been no specific treatment found for the spells yet. The aim of this study was to evaluate the efficacy of piracetam (2-oxo-l-pyrrolidineon these children.Materials & MethodsIn this randomized double blind clinical trial study, 150 children with severe BHS referred to our pediatric outpatient service were enrolled from August 2011 to July 2012. The patients were randomized into two equal groups.One received 40mg/kg/day piracetam and the other group received placebo,twice daily. Patients were followed monthly for three months. The number of attacks/month before and after treatment were documented.Results Of the enrolled patients, 86 were boys. The mean age of the patients was 17 months (range, 6 to 24 months. In the piracetam group, 1 month after treatment an 81% response to treatment was found. In the placebo group,none of the patients had complete remission and 7% of the cases had partial remission. Overall, control of breath-holding spells was observed in 91%of the patients in the group taking piracetam as compared with 16% in the group taking placebo at the end of the study. There was nosignificant difference detected between the groups regarding the prevalence of drug side effects.ConclusionA significant difference was detected between piracetam and placebo in prevention and controlling BHS. Piracetam (40mg/kg/day had a good effect on our patients.

  4. Effects of Piracetam on Pediatric Breath Holding Spells: A Randomized Double Blind Controlled Trial

    Science.gov (United States)

    ABBASKHANIAN, Ali; EHTESHAMI, Sara; SAJJADI, Sadegh; REZAI, Mohammad Sadegh

    2012-01-01

    Objective Breath holding spells (BHS) are common paroxysmal non-epileptic events in the pediatric population which are very stressfull despite their harmless nature. There has been no specific treatment found for the spells yet. The aim of this study was to evaluate the efficacy of piracetam (2-oxo-l-pyrrolidine) on these children. Materials & Methods In this randomized double blind clinical trial study, 150 children with severe BHS referred to our pediatric outpatient service were enrolled from August 2011 to July 2012. The patients were randomized into two equal groups. One received 40mg/kg/day piracetam and the other group received placebo, twice daily. Patients were followed monthly for three months. The number of attacks/month before and after treatment were documented. Results Of the enrolled patients, 86 were boys. The mean age of the patients was 17 months (range, 6 to 24 months). In the piracetam group, 1 month after treatment an 81% response to treatment was found. In the placebo group, none of the patients had complete remission and 7% of the cases had partial remission. Overall, control of breath-holding spells was observed in 91% of the patients in the group taking piracetam as compared with 16% in the group taking placebo at the end of the study. There was no significant difference detected between the groups regarding the prevalence of drug side effects. Conclusion A significant difference was detected between piracetam and placebo in prevention and controlling BHS. Piracetam (40mg/kg/day) had a good effect on our patients. PMID:24665274

  5. Whole-heart magnetic resonance coronary angiography with multiple breath-holds and automatic breathing-level tracking

    Science.gov (United States)

    Kuhara, Shigehide; Ninomiya, Ayako; Okada, Tomohisa; Kanao, Shotaro; Kamae, Toshikazu; Togashi, Kaori

    2010-05-01

    Whole-heart (WH) magnetic resonance coronary angiography (MRCA) studies are usually performed during free breathing while monitoring the position of the diaphragm with real-time motion correction. However, this results in a long scan time and the patient's breathing pattern may change, causing the study to be aborted. Alternatively, WH MRCA can be performed with multiple breath-holds (mBH). However, one problem in the mBH method is that patients cannot hold their breath at the same position every time, leading to image degradation. We have developed a new WH MRCA imaging method that employs both the mBH method and automatic breathing-level tracking to permit automatic tracking of the changes in breathing or breath-hold levels. Evaluation of its effects on WH MRCA image quality showed that this method can provide high-quality images within a shorter scan time. This proposed method is expected to be very useful in clinical WH MRCA studies.

  6. A multiple hold-out framework for Sparse Partial Least Squares.

    Science.gov (United States)

    Monteiro, João M; Rao, Anil; Shawe-Taylor, John; Mourão-Miranda, Janaina

    2016-09-15

    Supervised classification machine learning algorithms may have limitations when studying brain diseases with heterogeneous populations, as the labels might be unreliable. More exploratory approaches, such as Sparse Partial Least Squares (SPLS), may provide insights into the brain's mechanisms by finding relationships between neuroimaging and clinical/demographic data. The identification of these relationships has the potential to improve the current understanding of disease mechanisms, refine clinical assessment tools, and stratify patients. SPLS finds multivariate associative effects in the data by computing pairs of sparse weight vectors, where each pair is used to remove its corresponding associative effect from the data by matrix deflation, before computing additional pairs. We propose a novel SPLS framework which selects the adequate number of voxels and clinical variables to describe each associative effect, and tests their reliability by fitting the model to different splits of the data. As a proof of concept, the approach was applied to find associations between grey matter probability maps and individual items of the Mini-Mental State Examination (MMSE) in a clinical sample with various degrees of dementia. The framework found two statistically significant associative effects between subsets of brain voxels and subsets of the questions/tasks. SPLS was compared with its non-sparse version (PLS). The use of projection deflation versus a classical PLS deflation was also tested in both PLS and SPLS. SPLS outperformed PLS, finding statistically significant effects and providing higher correlation values in hold-out data. Moreover, projection deflation provided better results. Copyright © 2016 The Author(s). Published by Elsevier B.V. All rights reserved.

  7. SUMMARY AND RECOMMENDATIONS OF THE EXPERT PANEL OVERSIGHT COMMITTEE MEETING ON DOUBLE-SHELL TANK CORROSION MONITORING AND TESTING HELD AUGUST 4-5 2008

    Energy Technology Data Exchange (ETDEWEB)

    BOOMER KD

    2009-01-08

    The Expert Panel Oversight Committee (EPOC) on Double-Shell Tank Corrosion Monitoring and Testing has been overseeing the Fiscal Year FY 2008 experimental program being performed at CC Technologies (CCT) to optimize the chemistry control for corrosion limits in Double-Shell Tanks (DSTs). The EPOC met at the M & D Professional Services Conference Facility on August 4 and 5, 2008 to discuss various aspects of that responsibility including FY 2009 planning. Formal presentations were made to update the EPOC on the these subjects.

  8. The Determinants of Corporate Cash Holdings- An Empirical study from UK Firms

    OpenAIRE

    Guo, Yi

    2013-01-01

    Cash holding is most important financial decision in the company management strategy. In this dissertation, the determinants of corporate cash holdings in UK non-financial publicly traded firms over the period from 2003 to 2012 are investigated. Our study finds that growth opportunities and cash flow and cash flow variability are positively associated with the level of corporate cash holdings, while firm size, leverage, net working capital, bank debt and dividend payment have negative impact ...

  9. Adults' preferences for side-of-hold as portrayed in paintings of the Madonna and Child.

    Science.gov (United States)

    Harris, Lauren Julius; Cardénas, Rodrigo Andrés; Spradlin, Michael P; Almerigi, Jason B

    2009-11-01

    Most women hold infants on their left side. They do the same when depicted in works of art. Does the latter accurately reflect the real-life bias, the artist's own aesthetic preference, or something else, such as the artist's handedness, sex, direction of attentional bias, or even the artist's own side-preference for holding infants? As a first step to finding out, we showed 272 young adults (85 men, 187 women) 20 pairs of paintings of the Madonna and Child, the original on one side, its mirror-reversal on the other, and asked which one they preferred. Along with assessing the effects of the variables already mentioned, we used equal numbers of paintings originally depicting left-holds and right-holds to control for the possible effects of differences between the paintings other than side-of-hold itself, such as in their colour scheme, background details, and the type of hold shown (e.g., cradle vs seated on lap). Each pair was presented twice, once with the original on the left, once on the right, for a total of 40 trials. Women and men alike more often preferred left-hold images, but the difference was significant only for women. Preferences were also stronger for original left-hold paintings than for the mirror-reversals of original right-hold paintings, suggesting that the originals differed in ways affecting preference beyond those we tried to control. Overall preference for left-hold images was enhanced when the images were on the viewer's left. As for the other variables, they were for the most part unrelated to preferences. The reasons for the preference thus remain unclear but it is evidently affected by multiple variables, with at least some clearly different from those affecting side-of-hold preferences of real mothers holding real infants.

  10. Stock Liquidity and Corporate Cash Holdings: Feedback and the Cash as Ammunition Hypothesis

    OpenAIRE

    Nyborg, Kjell G.; Wang, Zexi

    2013-01-01

    The paper contributes to the literature on corporate cash holdings by showing that there is a financial markets channel that affects corporations’ cash holdings. Leaning on the literature on stock price feedback to firm fundamentals, we advance the hypothesis that firms with more liquid stocks hold more cash, ceteris paribus, as ammunition to defend against negative cascades or stimulate positive ones. This contrasts with an alternative view that firms with more liquid stocks are less financi...

  11. Novel hold-release functionality in a P300 brain-computer interface

    Science.gov (United States)

    Alcaide-Aguirre, R. E.; Huggins, J. E.

    2014-12-01

    Assistive technology control interface theory describes interface activation and interface deactivation as distinct properties of any control interface. Separating control of activation and deactivation allows precise timing of the duration of the activation. Objective. We propose a novel P300 brain-computer interface (BCI) functionality with separate control of the initial activation and the deactivation (hold-release) of a selection. Approach. Using two different layouts and off-line analysis, we tested the accuracy with which subjects could (1) hold their selection and (2) quickly change between selections. Main results. Mean accuracy across all subjects for the hold-release algorithm was 85% with one hold-release classification and 100% with two hold-release classifications. Using a layout designed to lower perceptual errors, accuracy increased to a mean of 90% and the time subjects could hold a selection was 40% longer than with the standard layout. Hold-release functionality provides improved response time (6-16 times faster) over the initial P300 BCI selection by allowing the BCI to make hold-release decisions from very few flashes instead of after multiple sequences of flashes. Significance. For the BCI user, hold-release functionality allows for faster, more continuous control with a P300 BCI, creating new options for BCI applications.

  12. Qualitative assessment of contrast-enhanced magnetic resonance angiography using breath-hold and non-breath-hold techniques in the portal venous system

    Science.gov (United States)

    Goo, Eun-Hoe; Kim, Sun-Ju; Dong, Kyung-Rae; Kim, Kwang-Choul; Chung, Woon-Kwan

    2016-09-01

    The purpose of this study is to evaluate the image quality in delineation of the portal venous systems with two different methods, breath-hold and non-breath-hold by using the 3D FLASH sequence. We used a 1.5 T system to obtain magnetic resonance(MR)images. Arterial and portal phase 3D FLASH images were obtained with breath-hold after a bolus injection of GD-DOTA. The detection of PVS on the MR angiograms was classified into three grades. First, the angiograms of the breath-hold method showed well the portal vein, the splenic vein and the superior mesenteric vein systems in 13 of 15 patients (86%) and the inferior mesenteric vein system in 6 of 15 patients (40%), Second, MR angiograms of the non-breath-hold method demonstrated the PVS and the SMV in 12 of 15 patients (80%) and the IMV in 5 of 15 patients (33%). Our study showed contrast-enhanced 3D FLASH MR angiography, together with the breath-hold technique, may provide reliable and accurate information on the portal venous system.

  13. Oversight framework over oocyte procurement for somatic cell nuclear transfer: comparative analysis of the Hwang Woo Suk case under South Korean bioethics law and U.S. guidelines for human embryonic stem cell research.

    Science.gov (United States)

    Kim, Mi-Kyung

    2009-01-01

    We examine whether the current regulatory regime instituted in South Korea and the United States would have prevented Hwang's potential transgressions in oocyte procurement for somatic cell nuclear transfer, we compare the general aspects and oversight framework of the Bioethics and Biosafety Act in South Korea and the US National Academies' Guidelines for Human Embryonic Stem Cell Research, and apply the relevant provisions and recommendations to each transgression. We conclude that the Act would institute centralized oversight under governmental auspices while the Guidelines recommend politically-independent, decentralized oversight bodies including a special review body for human embryonic stem cell research at an institutional level and that the Guidelines would have provided more vigorous protection for the women who had undergone oocyte procurement for Hwang's research than the Act. We also suggest additional regulations to protect those who provide oocytes for research in South Korea.

  14. Neonatal and pediatric respiratory care: what does the future hold?

    Science.gov (United States)

    DiBlasi, Robert M; Cheifetz, Ira M

    2011-09-01

    Neonatal and pediatric respiratory care continues to move forward at a truly impressive pace. Recent technologic advances and an increasing number of randomized clinical trials are leading to improved outcomes for neonates, infants, children, and adolescents with respiratory illness. The goals of this 47th Respiratory Care Journal Conference were to review pertinent recent advances in neonatal and pediatric respiratory care and, more importantly, to offer thoughts and perspectives for the future of our field. It is important to note that of the prior 46 Journal Conferences, only 2 have been dedicated to neonatal and/or pediatric respiratory care topics. It is our hope that the publication of these proceedings will provide respiratory therapists, physicians, and other members of the clinical care team a foundation on which to ponder the future of neonatal and pediatric respiratory care.

  15. Task Group report to the Assistant Secretary for Environment, Safety and Health on oversight of chemical safety at the Department of Energy. Volume 2, Appendices

    Energy Technology Data Exchange (ETDEWEB)

    1992-11-01

    This report presents the results of a preliminary review of chemical safety within the Department of Energy (DOE). The review was conducted by Chemical Safety Oversight Review (CSOR) Teams composed of Office of Environment, Safety and Health (EH) staff members and contractors. The primary objective of the CSOR was to assess, the safety status of DOE chemical operations and identify any significant deficiencies associated with such operations. Significant was defined as any situation posing unacceptable risk, that is, imminent danger or threat to workers, co-located workers, the general public, or the environment, that requires prompt action by EH or the line organizations. A secondary objective of the CSOR was to gather and analyze technical and programmatic information related to chemical safety to be used in conjunction with the longer-range EH Workplace Chemical Accident Risk Review (WCARR) Program. The WCARR Program is part of the ongoing EH oversight of nonnuclear safety at all DOE facilities. `` The program objective is to analyze DOE and industry chemical safety programs and performance and determine the need for additional or improved safety guidance for DOE. During the period June 6, 1992, through July 31, 1992, EH conducted CSORs at five DOE sites. The sites visited were Los Alamos National Laboratory (LANL), Savannah River Site (SRS), the Y-12 Plant (Y-12), Oak Ridge National Laboratory (ORNL), and Lawrence Livermore National Laboratory (LLNL).

  16. 12 CFR 575.12 - Conversion or liquidation of mutual holding companies.

    Science.gov (United States)

    2010-01-01

    ...—(1) Generally. A mutual holding company may convert to the stock form in accordance with the rules and regulations set forth in part 563b of this chapter. (2) Exchange of savings association stock. Any stock issued pursuant to § 575.7 by a subsidiary savings association or subsidiary holding company of...

  17. Exploring the financial rationales of Dutch forest holdings and their relation with financial results

    NARCIS (Netherlands)

    Hoogstra-Klein, M.A.

    2016-01-01

    The financial situation of many forest holdings inthe Netherlands is a major concern. For example, the yearly overview of Dutch private forest holdings larger than 5 ha shows that over the las t 30 years, the average annual results were negative during most years. However, it should be taken into ac

  18. 20 CFR 703.103 - Stock companies holding Treasury certificates of authority.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Stock companies holding Treasury certificates... REGULATIONS Authorization of Insurance Carriers § 703.103 Stock companies holding Treasury certificates of... the Secretary of the Treasury as an acceptable surety on Federal bonds, unless requested to do...

  19. 39 CFR 447.52 - Holding of State or local office by Postal Service employees.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Holding of State or local office by Postal Service employees. 447.52 Section 447.52 Postal Service UNITED STATES POSTAL SERVICE PERSONNEL RULES OF CONDUCT FOR POSTAL EMPLOYEES Participation in Community Affairs § 447.52 Holding of State or local office by Postal...

  20. The Ins and Outs of Breath Holding: Simple Demonstrations of Complex Respiratory Physiology

    Science.gov (United States)

    Skow, Rachel J.; Day, Trevor A.; Fuller, Jonathan E.; Bruce, Christina D.; Steinback, Craig D.

    2015-01-01

    The physiology of breath holding is complex, and voluntary breath-hold duration is affected by many factors, including practice, psychology, respiratory chemoreflexes, and lung stretch. In this activity, we outline a number of simple laboratory activities or classroom demonstrations that illustrate the complexity of the integrative physiology…

  1. 77 FR 20635 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-04-05

    ... From the Federal Register Online via the Government Publishing Office FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice... Officer) 90 Hennepin Avenue, Minneapolis, Minnesota 55480-0291: 1. Leackco Banking Holding Company,...

  2. Ape Behavior in Two Alternating Environments: Comparing Exhibit and Short-Term Holding Areas

    DEFF Research Database (Denmark)

    Ross, Stephen R.; Wagner, Katherine E.; Schapiro, Steven J.

    2010-01-01

    -specific reactions to the holding area, including increased aggression and self-directed behavior by chimpanzees and increased activity and prosocial behavior among gorilla subjects. Both species showed more feeding-foraging behavior while in the exhibit enclosure. Results suggest that holding areas may not meet all...

  3. 12 CFR 1500.3 - What are the holding periods permitted for merchant banking investments?

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false What are the holding periods permitted for merchant banking investments? 1500.3 Section 1500.3 Banks and Banking DEPARTMENT OF THE TREASURY GENERAL PROVISIONS MERCHANT BANKING INVESTMENTS § 1500.3 What are the holding periods permitted for merchant banking...

  4. 12 CFR 250.200 - Investment in bank premises by holding company banks.

    Science.gov (United States)

    2010-01-01

    ... company, is required to include indebtedness of a corporation, wholly owned by the holding company, that... “affiliate of each of the holding company's majority-owned banks as that term is defined in said section 2... is owned by such an affiliate, must include the affiliate's total indebtedness in determining...

  5. 75 FR 2544 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2010-01-15

    ... Commercial Bank, Lockport, New York, and thereby engage in operating a savings association, pursuant to... Central Financial, Inc., Annandale, Minnesota; to become a bank holding company by acquiring 100 percent... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this...

  6. Heterogeneity among methicillin-resistant Staphylococcus aureus from Italian pig finishing holdings

    DEFF Research Database (Denmark)

    Battisti, A.; Franco, A.; Merialdi, G.;

    2010-01-01

    A survey for methicillin-resistant Staphylococcus aureus (MRSA) in finishing pig holdings was carried out in Italy in 2008. MRSA isolates were characterised by spa-. SCCmec- and antimicrobial susceptibility typing. A prevalence of 38% (45/118, 95% CI 29.4-46.9%) positive holdings was observed...

  7. Do social factors influence investment behavior and performance? Evidence from mutual fund holdings

    NARCIS (Netherlands)

    Borgers, Arian; Derwall, J.M.M.; Koedijk, Kees; ter Horst, Jenke

    2015-01-01

    We study the economic significance of social dimensions in investment decisions by analyzing the holdings of U.S. equity mutual funds over the period 2004-2012. Using these holdings, we measure funds' exposures to socially sensitive stocks in order to answer two questions. What explains cross-sectio

  8. Audiovisual biofeedback guided breath-hold improves lung tumor position reproducibility and volume consistency

    Directory of Open Access Journals (Sweden)

    Danny Lee, PhD

    2017-07-01

    Conclusions: This study demonstrated that audiovisual biofeedback can be used to improve the reproducibility and consistency of breath-hold lung tumor position and volume, respectively. These results may provide a pathway to achieve more accurate lung cancer radiation treatment in addition to improving various medical imaging and treatments by using breath-hold procedures.

  9. Do social factors influence investment behavior and performance? Evidence from mutual fund holdings

    NARCIS (Netherlands)

    Borgers, Arian; Derwall, J.M.M.; Koedijk, Kees; ter Horst, Jenke

    We study the economic significance of social dimensions in investment decisions by analyzing the holdings of U.S. equity mutual funds over the period 2004-2012. Using these holdings, we measure funds' exposures to socially sensitive stocks in order to answer two questions. What explains

  10. 75 FR 71440 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2010-11-23

    ... York, which will continue to operate an equipment finance company, pursuant to sections 225.28(b)(1... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12...

  11. 75 FR 1384 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2010-01-11

    ... regulations to become a bank holding company and/or to acquire the assets or the ownership of, control of, or..., Missouri 64198-0001: 1. First National Management Group, LLC, Greenwood Village, Colorado; to become a bank... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this...

  12. 77 FR 76160 - New Generation Biofuels Holdings, Inc.; Order of Suspension of Trading

    Science.gov (United States)

    2012-12-26

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION New Generation Biofuels Holdings, Inc.; Order of Suspension of Trading December 21, 2012. It... concerning the securities of New Generation Biofuels Holdings, Inc. because it has not filed any periodic...

  13. 77 FR 51064 - Dana Holding Corporation, Power Technologies Group Division, Including On-Site Leased Workers...

    Science.gov (United States)

    2012-08-23

    ... Employment and Training Administration Dana Holding Corporation, Power Technologies Group Division, Including... Holding Corporation, Power Technologies Group Division, Milwaukee, Wisconsin (subject firm). The negative... competitive articles) in 2011 and 2012, loss of business with a firm that employed a worker group eligible...

  14. 78 FR 69605 - Standards for the Growing, Harvesting, Packing, and Holding of Produce for Human Consumption...

    Science.gov (United States)

    2013-11-20

    ... Growing, Harvesting, Packing, and Holding of Produce for Human Consumption; Extension of Comment Periods... Holding of Produce for Human Consumption'' and for its information collection provisions. DATES: The FDA... for Human Consumption.'' The original comment period of 120 days was extended several times and...

  15. 47 CFR 13.11 - Holding more than one commercial radio operator license.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Holding more than one commercial radio operator license. 13.11 Section 13.11 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMERCIAL RADIO OPERATORS General § 13.11 Holding more than one commercial radio operator license. (a) An eligible...

  16. 77 FR 52033 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-08-28

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  17. 76 FR 78658 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2011-12-19

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  18. 78 FR 23934 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-04-23

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  19. 78 FR 21949 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-04-12

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  20. 77 FR 50106 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-08-20

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  1. 77 FR 17479 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-03-26

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  2. 77 FR 54578 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-09-05

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  3. 76 FR 80945 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2011-12-27

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  4. 78 FR 23935 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-04-23

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  5. 77 FR 12057 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-02-28

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  6. 77 FR 61607 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-10-10

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  7. 78 FR 5179 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-01-24

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  8. 78 FR 35930 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-06-14

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... nonbanking company, the review also includes whether the acquisition of the nonbanking company complies...

  9. 77 FR 60435 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-10-03

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  10. 78 FR 37541 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-06-21

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  11. 78 FR 54647 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-09-05

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  12. 78 FR 67363 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-11-12

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  13. 78 FR 76146 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-12-16

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  14. 77 FR 41188 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-07-12

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice... company, the review also includes whether the acquisition of the nonbanking company complies with the... holding company through the acquisition of 100 percent of the voting shares of CNBO Bancorp, Inc.,...

  15. 77 FR 76039 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-12-26

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice... company, the review also includes whether the acquisition of the nonbanking company complies with the... bank holding company upon the merger of Flushing Savings Bank, FSB, Flushing, New York, with and...

  16. 77 FR 22786 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-04-17

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  17. 78 FR 28597 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-05-15

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  18. 78 FR 68445 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-11-14

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  19. 77 FR 59613 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-09-28

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  20. 77 FR 59195 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-09-26

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  1. 77 FR 15110 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-03-14

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  2. 77 FR 23249 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-04-18

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  3. 78 FR 18340 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-03-26

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  4. 77 FR 23482 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-04-19

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  5. 77 FR 65382 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-10-26

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  6. 77 FR 57088 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-09-17

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  7. 78 FR 19709 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-04-02

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  8. 76 FR 76412 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2011-12-07

    ...; to become a bank holding company by acquiring 100 percent of the voting shares of First Advantage... the voting shares of First Federal Savings and Loan Bank, Olathe, Kansas. D. Federal Reserve Bank of... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this...

  9. 12 CFR 225.102 - Bank holding company indirectly owning nonbanking company through subsidiaries.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Bank holding company indirectly owning nonbanking company through subsidiaries. 225.102 Section 225.102 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE IN...

  10. 31 CFR 597.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... as otherwise directed by the Office of Foreign Assets Control, any U.S. financial institution holding... under the Securities Exchange Act of 1934, provided the funds are invested in a money market fund or in... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Holding of funds in interest-bearing...

  11. 75 FR 22168 - Global Medical Products Holdings, Inc., Order of Suspension of Trading

    Science.gov (United States)

    2010-04-27

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Global Medical Products Holdings, Inc., Order of Suspension of Trading April 23, 2010. It appears... concerning the securities of Global Medical Products Holdings, Inc. because it has not filed any periodic...

  12. 12 CFR 16.9 - Securities offered and sold in holding company dissolution.

    Science.gov (United States)

    2010-01-01

    ... dissolution. 16.9 Section 16.9 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY SECURITIES OFFERING DISCLOSURE RULES § 16.9 Securities offered and sold in holding company dissolution. Offers and sales of bank issued securities in connection with the dissolution of the holding company of...

  13. 77 FR 30001 - PBF Holding Company LLC, Toledo Refining Company LLC v. Enbridge Energy, Limited Partnership...

    Science.gov (United States)

    2012-05-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission PBF Holding Company LLC, Toledo Refining Company LLC v. Enbridge Energy... to Oil Pipeline Proceedings, 18 CFR 343.1(a), PBF Holding Company LLC and Toledo Refining Company...

  14. 77 FR 10598 - BIOTECH Holdings Ltd., California Oil & Gas Corp., Central Minera Corp., Chemokine Therapeutics...

    Science.gov (United States)

    2012-02-22

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION BIOTECH Holdings Ltd., California Oil & Gas Corp., Central Minera Corp., Chemokine Therapeutics... concerning the securities of BIOTECH Holdings Ltd. because it has not filed any annual reports since...

  15. The effects of surface condition on abdominal muscle activity during single-legged hold exercise.

    Science.gov (United States)

    Ha, Sung-min; Oh, Jae-seop; Jeon, In-cheol; Kwon, Oh-yun

    2015-02-01

    To treat low-back pain, various spinal stability exercises are commonly used to improve trunk muscle function and strength. Because human movement for normal daily activity occurs in multi-dimensions, the importance of exercise in multi-dimensions or on unstable surfaces has been emphasized. Recently, a motorized rotating platform (MRP) for facilitating multi-dimensions dynamic movement was introduced for clinical use. However, the abdominal muscle activity with this device has not been reported. The purpose of this study was to compare the abdominal muscle activity (rectus abdominis, external and internal oblique muscles) during an active single-leg-hold (SLH) exercise on a floor (stable surface), foam roll, and motorized rotating platform (MRP). Thirteen healthy male subjects participated in this study. Using electromyography, the abdominal muscle activity was measured while the subjects performed SLH exercises on floor (stable surface), foam roll, and MRP. There were significant differences in the abdominal muscle activities among conditions (P.05) (Fig. 2). After the Bonferroni correction, however, no significant differences among conditions remained, except for differences in both side IO muscle activity between the floor and foam roll conditions (padjabdominal muscles activity in the multiple comparison between conditions (mean difference were smaller than the standard deviation in the abdominal muscle activities) (padj>0.017), except for differences in both side IO muscle activity between the floor (stable surface) and foam roll (padj<0.017) (effect size: 0.79/0.62 (non-supporting/supporting leg) for foam-roll versus floor).

  16. Assessment of Environmental Contamination and Environmental Decontamination Practices within an Ebola Holding Unit, Freetown, Sierra Leone.

    Directory of Open Access Journals (Sweden)

    Daniel Youkee

    Full Text Available Evidence to inform decontamination practices at Ebola holding units (EHUs and treatment centres is lacking. We conducted an audit of decontamination procedures inside Connaught Hospital EHU in Freetown, Sierra Leone, by assessing environmental swab specimens for evidence of contamination with Ebola virus by RT-PCR. Swabs were collected following discharge of Ebola Virus Disease (EVD patients before and after routine decontamination. Prior to decontamination, Ebola virus RNA was detected within a limited area at all bedside sites tested, but not at any sites distant to the bedside. Following decontamination, few areas contained detectable Ebola virus RNA. In areas beneath the bed there was evidence of transfer of Ebola virus material during cleaning. Retraining of cleaning staff reduced evidence of environmental contamination after decontamination. Current decontamination procedures appear to be effective in eradicating persistence of viral RNA. This study supports the use of viral swabs to assess Ebola viral contamination within the clinical setting. We recommend that regular refresher training of cleaning staff and audit of environmental contamination become standard practice at all Ebola care facilities during EVD outbreaks.

  17. Development of a deep inspiration breath-hold system for radiotherapy utilizing a laser distance measurer.

    Science.gov (United States)

    Jensen, Christer Andre; Skottner, Nils; Frengen, Jomar; Lund, Jo-Åsmund

    2017-01-01

    Deep inspiration breath-hold (DIBH) is a technique for treating left-sided breast cancer (LSBC). In modern radiotherapy, one of the main aims is to exclude the heart from the beam aperture with an individualized beam design for LSBC. A deep inhalation will raise the chest wall while the volume of the lungs increase, this will again push the heart away from the breast to be treated. There are a few commercial DIBH systems, both invasive and noninvasive. We present an alternative noninvasive DIBH system based upon an industrial laser distance measurer. This system can be installed in a treatment room at a low cost; it is very easy to use and requires limited amount of training for the personnel and the patient. The system is capable of measuring the position of the chest wall with high frequency and precision in real time. The patient views its breathing curve through video glasses, and gets instructions during the treatment session. The system is well tolerated by test subjects due to its noninvasiveness. © 2016 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

  18. Assessment of Environmental Contamination and Environmental Decontamination Practices within an Ebola Holding Unit, Freetown, Sierra Leone.

    Science.gov (United States)

    Youkee, Daniel; Brown, Colin S; Lilburn, Paul; Shetty, Nandini; Brooks, Tim; Simpson, Andrew; Bentley, Neil; Lado, Marta; Kamara, Thaim B; Walker, Naomi F; Johnson, Oliver

    2015-01-01

    Evidence to inform decontamination practices at Ebola holding units (EHUs) and treatment centres is lacking. We conducted an audit of decontamination procedures inside Connaught Hospital EHU in Freetown, Sierra Leone, by assessing environmental swab specimens for evidence of contamination with Ebola virus by RT-PCR. Swabs were collected following discharge of Ebola Virus Disease (EVD) patients before and after routine decontamination. Prior to decontamination, Ebola virus RNA was detected within a limited area at all bedside sites tested, but not at any sites distant to the bedside. Following decontamination, few areas contained detectable Ebola virus RNA. In areas beneath the bed there was evidence of transfer of Ebola virus material during cleaning. Retraining of cleaning staff reduced evidence of environmental contamination after decontamination. Current decontamination procedures appear to be effective in eradicating persistence of viral RNA. This study supports the use of viral swabs to assess Ebola viral contamination within the clinical setting. We recommend that regular refresher training of cleaning staff and audit of environmental contamination become standard practice at all Ebola care facilities during EVD outbreaks.

  19. SU-C-19A-01: A Simple Deep Inspiration Breath Hold System

    Energy Technology Data Exchange (ETDEWEB)

    Rasmussen, B; Kaznowski, L; Blackburn, J; Chu, K [Marquette General Hospital, Marquette, MI (United States); Duelge, J; Baldwin, B; Valenti, M; Hunsader, A [Dickinson County Healthcare System, Iron Mountain, MI (United States)

    2014-06-15

    Purpose: Deep Inspiration Breath Hold (DIBH) Radiation therapy for left sided breast can reduce dose to the lungs and heart. The purpose of this work is to illustrate how to implement a simple method of DIBH for simulation and treatment using equipment readily available in most radiation oncology clinics. Methods: For simulation and treatment, a foam block is placed on the patient's abdomen or chest and a horizontal laser mounted on a movable slide is aimed at the center of the foam block. After a coaching session the block is marked at the average free breathing position and average DIBH position. The position of block relative to laser can be seen by the patient via prism glasses as well as the radiation therapists via a video camera system. Simulation CT scans and treatment delivery are performed under DIBH conditions. Imaging and treatment are performed by manually turning the beam on once the patient has achieved DIBH after being given verbal instructions. Results: Manually triggered imaging was used daily to verify DIBH reproducibility for all patients treated using this system. Sets of before and during port images were used to ensure patient position was appropriate for treatment. Results of the laser on block method were compared to a sister facility using surface mapping techniques for DIBH and the two methods were found to have clinically equivalent reproducibility. Conclusion: The laser and block system was found to be simple to implement and robust during patient treatment. This system can be created from readily available materials at low cost and provides adequate feedback to patient and therapists. During treatment images document the reproducibility of setup and give confidence to clinicians that this method is reproducible from day to day.

  20. Magnetic resonance spectroscopy may hold promise in studying metabolites, tissues

    Energy Technology Data Exchange (ETDEWEB)

    1989-02-24

    Almost 15 years ago, in a basement at Chicago's University of Illinois Medical Center, Michael Barany, MD, PhD, measured phosphorus metabolites in an intact frog muscle using magnetic resonance spectroscopy (MRS). Prior to that, chemists used spectroscopy solely to analyze the contents of test tubes. Only a British group preceded Barany in proving that it would work in tissue as well. Today, he does spectroscopy clinically, one day a week, at the Greenberg Radiology Institute in Highland Park, IL, north of Chicago. Barany says that he can distinguish malignant from benign tumors in the living brain. The tool he uses is a standard magnetic resonance imaging (MRI) machine. While MRI capabilities have forged ahead, human MRS has been awaiting improvements in magnet and computer technology. Barany is one of a number of researchers who, since the early 1980s, have been developing MRS technology and techniques so that it can be done in the human body.

  1. Horizons in clinical nanomedicine

    CERN Document Server

    Karagkiozaki, Varvara

    2014-01-01

    Nanomedicine-the application of nanotechnology to health sciences-has the potential to address many important medical problems by exploiting the advanced physicochemical characteristics of nanostructured materials and devices. It can revolutionize conventional medicine by offering cutting-edge developments in the processes of diagnosing, treating, and preventing diseases, injuries, or genetic disorders. Thus, clinical nanomedicine holds promise to preserve and improve human health.This book provides a comprehensive overview on the forefront developments of nanotechnology in various domains of

  2. Analysis of cash holding for measuring the efficiency of cash management: A study on IT sector

    Directory of Open Access Journals (Sweden)

    Somnath Das

    2015-01-01

    Full Text Available For measuring the efficiency of management of cash, cash holding is one of the most important financial decisions that the manager of the concerned organization, has to make in the organization. Basically, it is observed that the organization hold cash for future purposes is very negligible. If the organization invested cash in profitable securities then there is some flexibility but when it relates to the capital market holding cash is not advantageous. Generally two contradictory theories such as Trade-off theory and the Pecking order theory are considered for measuring the efficiency of cash management. In this study we generally observed measured the efficiency of Cash Management influenced by Cash Holding. We also measured whether cash holding of the organization is affected with the degree of financial leverage, size of the organization, investment and profitability. This study helps us to understand the influence of DFL, Investment and Size of the organization on Cash holding. Proper holding of cash in cash management can prevent the bankruptcy of any organization and also increases the efficiency of Cash or Liquidity management.

  3. EVALUATION OF THE IMPACT OF INNOVATIVE PROJECTS ON THE COMPETITIVENESS OF AGRICULTURAL HOLDINGS IN SLOVAK REPUBLIC

    Directory of Open Access Journals (Sweden)

    Ľubica RUMANOVSKÁ

    2013-01-01

    Full Text Available The scientific paper evaluates the impact of innovative projects on the competitiveness of agricultural holdings in SR. Evaluation of the impact of innovative projects on competitiveness of agricultural holdings was realized on the selected holdings in Nitra and Trnava region. For the evaluation was used RCR coefficient. With the use of RCR coefficient could be confirmed the scientific hypothesis - The innovative projects realized through Program for rural development SR 2007-2013 have positive impact on competitiveness of agricultural holdings. The possibilities for EU financial support for innovative projects in SR represent important source for introduction of new innovative technologies into production process and in future they can significantly contribute to the growth of competitiveness of agricultural subjects. Therefore, to increase competitiveness of agricultural holdings it is important to focus on modernization of machinery and buildings, use of natural sources for energy production, but also to increase the education and the flow of information between rural inhabitants, mainly farmers. In competitive area of EU agricultural sector it is necessary that agricultural holdings will innovate, not only to create independent flow of innovative products and knowledge, but also to increase its value on internal market. Agricultural holdings –receivers of financial support – have expressed the opinion that financial support realized through PRD SR 2007-2013 had definitely allowed them to implement new processes and products.

  4. Single breath hold 3D cardiac cine MRI using kat-ARC: preliminary results at 1.5T.

    Science.gov (United States)

    Jeong, Daniel; Schiebler, Mark L; Lai, Peng; Wang, Kang; Vigen, Karl K; François, Christopher J

    2015-04-01

    Validation of a new single breath-hold, three-dimensional, cine balanced steady-state free precession (3D cine bSSFP) cardiac magnetic resonance (CMR) sequence for left ventricular function. CMR examinations were performed on fifteen patients and three healthy volunteers on a clinical 1.5T scanner using a two-dimensional (2D) cine balanced SSFP CMR sequence (2D cine bSSFP) followed by an investigational 3D cine bSSFP pulse sequence acquired within a single breath hold. Left ventricular end diastolic volume (LVEDV), end systolic volume (LVESV), ejection fraction (LVEF), and myocardial mass were independently segmented on a workstation by two experienced radiologists. Blood pool to myocardial contrast was evaluated in consensus using a Likert scale. Bland-Altman analysis was used to compare these quantitative and nominal measurements for the two sequences. The average acquisition time was significantly shorter for the 3D cine bSSFP than for 2D cine bSSFP (0.36 ± 0.03 vs. 8.5 ± 2.3 min) p = 0.0002. Bland-Altman analyses [bias and (limits of agreement)] of the data derived from these two methods revealed that the LVEF 0.9% (-4.7, 6.4), LVEDV 4.9 ml (-23.0, 32.8), LVESV -0.2 ml (-22.4, 21.9), and myocardial mass -0.4 g (-23.8, 23.0) were not significantly different. There was excellent intraclass correlation for intra-observer variability (0.981, 0.989, 0.997, 0.985) and inter-observer variability (0.903, 0.954, 0.970, 0.842) for LVEF, LVEDV, LVESV, and myocardial mass respectively. 3D cine bSSFP allows for accurate single breath-hold volumetric cine CMR which enables substantial improvements in scanner time efficiency without sacrificing diagnostic accuracy.

  5. Determination of ethane, pentane and isoprene in exhaled air--effects of breath-holding, flow rate and purified air.

    Science.gov (United States)

    Lärstad, M A E; Torén, K; Bake, B; Olin, A-C

    2007-01-01

    Exhaled ethane, pentane and isoprene have been proposed as biomarkers of oxidative stress. The objectives were to explore whether ethane, pentane and isoprene are produced within the airways and to explore the effect of different sampling parameters on analyte concentrations. The flow dependency of the analyte concentrations, the concentrations in dead-space and alveolar air after breath-holding and the influence of inhaling purified air on analyte concentrations were investigated. The analytical method involved thermal desorption from sorbent tubes and gas chromatography. The studied group comprised 13 subjects with clinically stable asthma and 14 healthy controls. Ethane concentrations decreased slightly, but significantly, at higher flow rates in subjects with asthma (P = 0.0063) but not in healthy controls. Pentane levels were increased at higher flow rates both in healthy and asthmatic subjects (P = 0.022 and 0.0063 respectively). Isoprene levels were increased at higher flow rates, but only significantly in healthy subjects (P = 0.0034). After breath-holding, no significant changes in ethane levels were observed. Pentane and isoprene levels increased significantly after 20 s of breath-holding. Inhalation of purified air before exhalation resulted in a substantial decrease in ethane levels, a moderate decrease in pentane levels and an increase in isoprene levels. The major fractions of exhaled ethane, pentane and isoprene seem to be of systemic origin. There was, however, a tendency for ethane to be flow rate dependent in asthmatic subjects, although to a very limited extent, suggesting that small amounts of ethane may be formed in the airways.

  6. EXCESS CASH HOLDINGS DAN KEPEMILIKAN INSTITUSIONAL PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BEI

    Directory of Open Access Journals (Sweden)

    Yessica Tria Christina

    2014-02-01

    Full Text Available This research provides an empirical evidence about the effect of institutional ownerships as a proxy of information transparancy on excess cash holdings. Manufacture companies listed on BEI from years 2002 to 2011 are employed. The results show that the higher the proportion of institutional ownership, the lower the excess cash holdings. Informational transparancy, as one of the requirements of good corporate governance, can in fact lower the chance of aggrevating the manager’s behavior to practice excess cash holdings that can lower the company’s efficiency.

  7. Organizational suggestion system in the era of holding by developing an innovative model : the case of bonyade ta avon holding in Iran(an applied model

    Directory of Open Access Journals (Sweden)

    Meysam Ghasemi

    2010-01-01

    Full Text Available One of the popular ways of taking advantage of personnel creativity is through suggestionsystems. Our main question is how to implement suggestion system in holding with conglomeratestructure. The paper presents an innovative model that were named ITFSK Model with accordanceof Bonayade Taavone (a holding that has many companies and institutions with conglomeratestructure. ITFSK is a model that explains how participation management and suggestion system isimplemented effectively in huge Enterprises (holding and this approach brings continuousimprovement (kaizen and it impacts the productivity of these enterprises.The paper is based on field research and the research in Bonyade Tavan that has 22 companies and2 institutions that activity fields of the subholdings is very varied.Our model consists of five main parts such as ideas bank, think-tank, feedback, sharing ofknowledge and kaizen that was named ITFSK.Implementation of “Suggestion system” rules has immediate and significant effects on theproductivity of activities in the jobs, thus influencing the performance of processes in the analyzedorganization. Suggestion system can result in kaizen and innovation in environment oforganization.The model was used to implement and evaluate a suggestion system of holding with conglomeratedstructure. The application of the model to evaluate the suggestion system provided some goodinsights and highlighted some areas of improvement.

  8. Key Concepts of Clinical Trials: A Narrative Review

    Science.gov (United States)

    Umscheid, Craig A.; Margolis, David J.; Grossman, Craig E.

    2012-01-01

    The recent focus of federal funding on comparative effectiveness research underscores the importance of clinical trials in the practice of evidence-based medicine and health care reform. The impact of clinical trials not only extends to the individual patient by establishing a broader selection of effective therapies, but also to society as a whole by enhancing the value of health care provided. However, clinical trials also have the potential to pose unknown risks to their participants, and biased knowledge extracted from flawed clinical trials may lead to the inadvertent harm of patients. Although conducting a well-designed clinical trial may appear straightforward, it is founded on rigorous methodology and oversight governed by key ethical principles. In this review, we provide an overview of the ethical foundations of trial design, trial oversight, and the process of obtaining approval of a therapeutic, from its pre-clinical phase to post-marketing surveillance. This narrative review is based on a course in clinical trials developed by one of the authors (DJM), and is supplemented by a PubMed search predating January 2011 using the keywords “randomized controlled trial,” “patient/clinical research,” “ethics,” “phase IV,” “data and safety monitoring board,” and “surrogate endpoint.” With an understanding of the key principles in designing and implementing clinical trials, health care providers can partner with the pharmaceutical industry and regulatory bodies to effectively compare medical therapies and thereby meet one of the essential goals of health care reform. PMID:21904102

  9. MORT User's Manual for use with the Management Oversight and Risk Tree analytical logic diagram. [Contains a list of System Safety Development Center publications

    Energy Technology Data Exchange (ETDEWEB)

    Knox, N.W.; Eicher, R.W.

    1992-02-01

    This report contains the User's Manual for MORT (Management Oversight and Risk Tree), a logic diagram in the form of a work sheet'' that illustrates a long series of interrelated questions. MORT is a comprehensive analytical procedure that provides a disciplined method for determining the causes and contributing factors of major accidents. Alternatively, it serves as a tool to evaluate the quality of an existing system. While similar in many respects to fault tree analysis, MORT is more generalized and presents over 1,500 specific elements of an ideal universal'' management program for optimizing environment, safety and health, and other programs. This User's Manual is intended to be used with the MORT diagram dated February 1992.

  10. Estimation of population dose and risk to holding assistants from veterinary X-ray examination in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Hashizume, Tadashi; Suganuma, Tunenori; Shida, Takuo (Azabu Univ., Kanagawa (Japan). School of Veterinary Medicine)

    1989-09-01

    For the estimation of the population doses and risks of stochastic effects to assistants who hold animals during veterinary X-ray examination, a random survey of hospitals and clinics was carried out concerning age distribution of such assistants by groups of facilities. The average organ and tissue dose per examination was evaluated from the experimental data using mean technical factors such as X-ray tube voltage, tube current and field size based on the results of a nationwide survey. The population doses to the assistants were calculated to be about 14 nSv per person per year for the genetically significant dose, 3.5 nSv per person per year for per caput mean marrow dose, 3.3 nSv for the leukemia significant dose and 4.5 nSv for the malignant significant dose, respectively. The total risk of stochastic effects to the Japanese population from holding assistants was estimated using population data and it was estimated to be less than one person per year, but the cancer risks to a number of the assistants were estimated to be more than 4 x 10{sup -5}. (author).

  11. 77 FR 27061 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-05-08

    ... South LaSalle Street, Chicago, Illinois 60690-1414: 1. Johnston Growth Corporation, Johnston, Iowa; to become a bank holding company following the conversion of its subsidiary, Charter Bank, Johnston,...

  12. Factors Affecting Corporate Cash Holding of Non-Financial Firms in Pakistan

    Directory of Open Access Journals (Sweden)

    Atif Kafayat

    2014-06-01

    Full Text Available The previous researches explore the question of why firms hold cash. But there are few researches done in developing countries like Pakistan. The need for cash is characterized by its policies of firms regarding capital structure, working capital requirements, cash flow management, dividend payments, and asset management. In this paper, the impact of these factors is normally analyzed under the framework of Tradeoff theory, Pecking Order Theory and Free Cash Flow Theory. This paper focuses on determining the level of corporate cash holdings of non-financial Pakistani firms, and cash holding requirement among different industries. The data is set for period of 2008- 2012 by using the data of 40companies and 6 industries. The findings of the study support the theories. Which show that firm size, net working capital, leverage, Capital Expenditure and Dividend significantly affect the cash holdings of non-financial firms in Pakistan.

  13. Determinants of corporate cash holdings: Evidence from Portuguese publicly traded firms

    Directory of Open Access Journals (Sweden)

    Fernandes, Filipa

    2017-05-01

    Full Text Available This paper investigates the determinants of cash holdings of publicly traded Portuguese firms. We find that such firms hold less cash than similar companies operating in countries where both shareholders and creditors’ rights are more tightly protected by the law. In addition, our regression results suggest that leverage, other liquid assets, and firm growth are negatively correlated with our sample firms’ cash holdings whereas long-term debt and financial distress are positively correlated. Our findings cannot be reconciled with just one of the existent theories (trade-off, pecking order and free cashflow theory, and emphasize the importance of a country’s legal, institutional, and economic environment for explaining firms’ cash holdings decisions.

  14. Extension, cooperatives to hold 34th annual Forestry and Wildlife Field Tours

    OpenAIRE

    2010-01-01

    Virginia Cooperative Extension and the Virginia Forest Landowner Education Program in Virginia Tech's College of Natural Resources and Environment will hold their 34th Annual Fall Forestry and Wildlife Field Tour Programs starting Oct. 15.

  15. 46 CFR 154.902 - Atmospheric control within hold and interbarrier spaces.

    Science.gov (United States)

    2010-10-01

    ... containment systems with full secondary barriers must have an inert gas system or onboard storage of inert gas... must: (1) Have an inert gas system or onboard inert gas storage that can inert the largest hold...

  16. 78 FR 59938 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-09-30

    ... the power to vote shares of a bank or bank holding company and all of the banks and nonbanking...) 230 South LaSalle Street, Chicago, Illinois 60690-1414: 1. MB Financial, Inc., Chicago, Illinois;...

  17. Report: EPA Managers Did Not Hold Supervisors and Project Officers Accountable for Grants Management

    Science.gov (United States)

    Report #2005-P-00027, September 27, 2005. Managers did not sufficiently hold supervisors and project officers accountable for grants management because there is no process to measure most grants management activity.

  18. Extension, cooperatives to hold 33rd annual Forestry and Wildlife Field Tours

    OpenAIRE

    2009-01-01

    Virginia Cooperative Extension and the Virginia Forest Landowner Education Program, in collaboration with Virginia's natural resource agencies, companies, and associations, will hold their 33rdth Annual Fall Forestry and Wildlife Field Tours starting Sept. 24.

  19. A metal aerosol holding chamber devised for young children with asthma

    DEFF Research Database (Denmark)

    Bisgaard, H

    1995-01-01

    The low tidal volume and flow in preschool children may reduce the efficiency of aerosol delivery from a pressurized metered-dose inhaler (pMDI) through a traditional holding chamber. A prototype small-volume steel holding chamber with two one-way valves was devised to prolong aerosol availability...... children less than 8 yrs of age. In vitro, the half life of aerosol disappearance in the steel prototype and the plastic Nebuhaler was > 30 s and 9 s, respectively. In vivo, the prototype delivered an age-independent mean dose of 38% of the nominal dose, and the Nebuhaler delivered an age-dependent mean...... be achieved by pMDI aerosol inhaled through a small-volume metal holding chamber with separate inlet and outlet valves and minimized dead space. This holding chamber would improve the possibilities of aerosol therapy for young children....

  20. 75 FR 11888 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2010-03-12

    .... PBS Bancshares, Inc., Seneca, Missouri; to become a bank holding company by acquiring 87.31 percent of the voting shares of People's Bank of Seneca, Seneca, Missouri. B. Federal Reserve Bank of...

  1. 5 CFR 1690.15 - Freezing an account-administrative holds.

    Science.gov (United States)

    2010-01-01

    ... SAVINGS PLAN Miscellaneous § 1690.15 Freezing an account—administrative holds. (a) The TSP may freeze (e.g...) Pursuant to a request from the Department of Justice under the Mandatory Victims Restitution Act; (3) Upon...

  2. 76 FR 16477 - General Reporting and Recordkeeping by Savings Associations and Savings and Loan Holding Companies

    Science.gov (United States)

    2011-03-23

    ... infocollection.comments@ots.treas.gov . OTS will post comments and the related ] index on the OTS Internet Site... each savings and loan holding company), 12 CFR part 226 (Regulation Z, truth in lending), 12 CFR...

  3. MONDAY: EPA to Hold U.S.-Mexico Border 2020 Conference

    Science.gov (United States)

    DALLAS - (Sept. 21, 2015) The U.S-Environmental Protection Agency (EPA) and the Mexican Environment and Natural Resources Secretariat (SEMARNAT) are holding their first biennial national coordinators meeting. The meeting is part of the Border 2020 U

  4. Determination of the column hold-up volume in supercritical fluid chromatography using nitrous-oxide.

    Science.gov (United States)

    Vajda, Péter; Guiochon, Georges

    2013-09-27

    This study introduces a new tracer that is useful for the determination of the hold-up time or volume of packed columns, particularly of those used in supercritical fluid chromatography. The thermodynamic void volume of three columns packed with different adsorbents were determined using the weight difference method. These void volumes were used as the reference point in the further discussion. The hold-up volumes of these columns were determined under dynamic conditions, using nitrous oxide dissolved in methanol as the hold-up time marker. Changes in the hold-up volumes of these columns were monitored during changes of the volumetric flow rate of pure supercritical carbon dioxide and of dilute mixtures of organic modifier and supercritical carbon dioxide. The results suggest significant methanol enrichment on the adsorbent surface.

  5. 78 FR 1265 - Dana Holding Corporation; Power Technologies Group Division; Including On-Site Leased Workers...

    Science.gov (United States)

    2013-01-08

    ... Employment and Training Administration Dana Holding Corporation; Power Technologies Group Division; Including... Technologies Group Division, Milwaukee, Wisconsin (subject firm). The worker group includes on-site leased... Company, Power Technologies Group Division, Milwaukee, Wisconsin, who were engaged in employment...

  6. Network analysis of pig movements: Loyalty patterns and contact chains of different holding types in Denmark

    DEFF Research Database (Denmark)

    Schulz, Jana; Boklund, Anette; Hisham Beshara Halasa, Tariq

    2017-01-01

    , the number of registered movements and the number of pigs moved. To identify holdings and holding types with potentially higher risk for introduction or spread of diseases via pig movements, we determined loyalty patterns, annual network components and contact chains for the 24 registered holding types...... time period. Weaner herds showed the highest level of in-loyalty, whereas we observed an intermediate level of in-loyalty for all breeding sites and for production herds. Boar stations, production herds and trade herds showed a high level of out-loyalty. Production herds constituted the highest......-going contact chains. Our results reflect the pyramidal structure of the underlying network. Based on the considered disease, the time frame for the calculation of network measurements needs to be adapted. Using these adapted values for loyalty and contact chains might help to identify holdings with high...

  7. Microbial sequencing analyses suggest the presence of a fecal veneer on indoor climbing wall holds.

    Science.gov (United States)

    Bräuer, S L; Vuono, D; Carmichael, M J; Pepe-Ranney, C; Strom, A; Rabinowitz, E; Buckley, D H; Zinder, S H

    2014-11-01

    Artificial climbing walls represent a unique indoor environment in which humans interact closely with a variety of surface types. Climbing wall holds may mediate transmission of organisms between individuals, and yet there are no studies that identify microorganisms present on these surfaces. In the current study, the microorganisms found on climbing wall holds were characterized by analysis of amplified SSU rRNA gene sequences. In contrast to many other studies of built environments, the majority of microorganisms on holds were most closely related to microbes annotated as being recovered from environmental sources, such as soil, with human skin also representing an important source. Regional patterns were evident as rRNA gene sequences from the marine cyanobacterium Prochlorococcus were abundant in gyms found within 16 km of the ocean. Enterobacteriaceae were present on 100 % of holds surveyed, and the members detected are commonly associated with fecal matter.

  8. 17 CFR 210.3A-05 - Special requirements as to public utility holding companies.

    Science.gov (United States)

    2010-04-01

    ... companies. There shall be shown in the consolidated balance sheet of a public utility holding company the... COMPANY ACT OF 1940, INVESTMENT ADVISERS ACT OF 1940, AND ENERGY POLICY AND CONSERVATION ACT OF...

  9. Diverse Presentation of Breath Holding Spells: Two Case Reports with Literature Review

    Directory of Open Access Journals (Sweden)

    Geetanjali Rathore

    2013-01-01

    Full Text Available Breath holding spells are a common and dramatic form of syncope and anoxic seizure in infancy. They are usually triggered by an emotional stimuli or minor trauma. Based on the color change, they are classified into 3 types, cyanotic, pallid, and mixed. Pallid breath holding spells result from exaggerated, vagally-mediated cardiac inhibition, whereas the more common, cyanotic breathholding spells are of more complex pathogenesis which is not completely understood. A detailed and accurate history is the mainstay of diagnosis. An EKG should be strongly considered to rule out long QT syndrome. Spontaneous resolution of breath-holding spells is usually seen, without any adverse developmental and intellectual sequelae. Rare cases of status epilepticus, prolonged asystole, and sudden death have been reported. Reassurance and education is the mainstay of therapy. Occasionally, pharmacologic intervention with iron, piracetam; atropine may be of benefit. Here we present 2 cases, one of each, pallid and cyanotic breath holding spells.

  10. POETICS OF THE ABSURD IN OLA ROTIMI’S HOLDING TALKS: A MANUAL FOR DIRECTORS

    Directory of Open Access Journals (Sweden)

    Dr. Odiri Solomon Ejeke

    2013-07-01

    Full Text Available The study analyzes Ola Rotimi’s Holding Talks directorially. In the analysis, the study places the play on its proper aesthetic base. The study is aimed at directors and theatre practitioners who might find this interpretation useful and as a guide for further practical theatre projects from a directorial perspective. The study consequently explains the thematic concepts of Holding Talks, relating the dramatic events to the Nigerian socio-political set up.

  11. A Comprehensive Program for the Enhancement of Accrual to Clinical Trials.

    Science.gov (United States)

    Porter, Mark; Ramaswamy, Bhuvaneswari; Beisler, Karen; Neki, Poonam; Single, Nancy; Thomas, James; Hofacker, Janie; Caligiuri, Michael; Carson, William E

    2016-07-01

    The Ohio State University Comprehensive Cancer Center (OSUCCC) embarked on a single institution campaign over 2 years to enhance the enrollment of cancer patients into therapeutic clinical trials. The goal of this campaign was to achieve a 40 % increase in accrual over a 2-year period. The entire process of accruing patients to clinical trials at the OSUCCC was carefully evaluated and broken down into several interlocking components. The four key areas of emphasis were as follows: (i) tasking of OSUCCC leadership with increased oversight of the entire process; (ii) education of all stakeholders [patients, their families, nurses and staff, physicians (both internal and external), Disease-Specific Committees (DSCs), and the OSUCCC leadership] as to the purpose, advantages, and availability of clinical trials, with an emphasis on accrual to cancer clinical trials (CCTs) being a critical function of all OSUCCC employees; (iii) increased oversight of the portfolio of clinical trials by DSCs; and (iv) optimization of accrual operations and infrastructure center-wide. The accrual goal was achieved a full 4 months ahead of schedule. In total, 2327 patients were accrued to therapeutic clinical trials over the course of this 2-year campaign. Prior to implementation of the accrual program, the accrual rate was consistently below 15 %. From 2009 onwards, the therapeutic accrual rate was always greater than 25 %. A campaign to educate key stakeholders in the clinical trials accrual process was successful in its goal of increasing accrual to therapeutic trials.

  12. Research on Precipitate Behavior during Holding Process of X80 Pipeline Steel

    Directory of Open Access Journals (Sweden)

    Niu Tao

    2016-01-01

    Full Text Available PTT (Precipitate-Temperature-Time curve of X80 pipeline steel was obtained by strain relaxation method. The evolution of precipitate particle size during holding process was simulated combined with kinetic calculation, and observed using TEM in the samples of industrial produced X80 steel with different holding time. It is revealed that the shape of PPT curve is typical “C” type with the nose temperature of 900°C and incubation time of about 5s. Kinetic calculation results show that the average particle size increases obviously with the increment of holding time. Meantime, after holding for 90s at 950°C, observation of industrial produced X80 steel reveals that the proportion of precipitate particles larger than 60nm increases dramatically, which basically agreed with the calculation results. Dissolved Nb can effectively reduce grain boundary mobility and retard recrystallization by solute drag effect. Therefore, it is strongly recommended to shorten the holding time without increasing holding temperature in industrial production, so that to reduce precipitate of Nb at high temperature, and increase the strength and toughness of steel.

  13. Cardiac Repolarization Changes in the Children with Breath-Holding Spells

    Science.gov (United States)

    Amoozgar, Hamid; Saleh, Fazl; Farhani, Nahal; Rafiei, Mohammad; Inaloo, Soroor; Asadipooya, Ali-Akbar

    2013-01-01

    Objective Breath-holding spells are known as benign attacks, frequencies of which decrease by the development of the autonomic nervous system. The present study aims to compare the electrocardiographic repolarization in children with breath-holding spells. Methods In this study, QT dispersion, QTc dispersion, T peak to T end dispersion, and P wave dispersion of the twelve-lead surface electrocardiography of fifty children who had breath-holding spells were measured and compared with normal children from April 2011 to August 2012. Findings Forty-four (88%) patients had cyanotic spells, while 6 (12%) had pallid spells. QTc dispersion was increased in the patients with breath-holding spells (148.2±33.1) compared to the healthy children (132±27.3) and the difference was statically significant (P = 0.01). Meanwhile, no statistically significant differences were observed between the patients and the control subjects regarding the other parameters (P > 0.05). Conclusion QTc dispersion was significantly increased in the patients with breath-holding spells compared to normal children and this is a sign of cardiac repolarization abnormality as well as the increased risk of cardiac arrhythmia in patients with breath-holding spells. PMID:24910749

  14. 78 FR 50410 - Black Bear Development Holdings, LLC; Supplemental Notice that Initial Market-Based Rate Filing...

    Science.gov (United States)

    2013-08-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Black Bear Development Holdings, LLC; Supplemental Notice that Initial... notice in the above-referenced proceeding of Black Bear Development Holdings, LLC's application...

  15. 77 FR 36041 - Nevada 5, Inc. and Oakland Transportation Holdings LLC-Control Exemption-GTR Leasing LLC and US...

    Science.gov (United States)

    2012-06-15

    ... Exemption--GTR Leasing LLC and US Rail Holdings LLC \\1\\ \\1\\ Applicants styled the transaction as a... (Rail Holdings), a Class III rail carrier, through Oakland's acquisition of GTR Leasing LLC (GTR),...

  16. Effectiveness of a lower lingual arch as a space holding device.

    Science.gov (United States)

    Owais, A I; Rousan, M E; Badran, S A; Abu Alhaija, E S

    2011-02-01

    The aims of this study were to evaluate the effectiveness of a lower lingual holding arch (LLHA) in maintaining arch length, and to compare the effectiveness of two LLHAs made of two different gauges (0.9 and 1.25 mm) of stainless steel (SS) wire. The sample comprised 44 subjects (24 males and 20 females) who for various reasons attended orthodontic clinics at Jordan University of Science and Technology Dental Teaching Center. The subjects were randomly divided into two treatment groups. The first group contained 20 subjects (12 males/8 females, average age 10.76 ± 0.75 years). The LLHA used in this group was made of 0.9 mm SS wire. The second group comprised 24 subjects (12 males/12 females, average age 10.57 ± 0.54 years). The LLHA used in this group was made of 1.25 mm SS wire. The third group consisted of 23 subjects (15 males/8 females, average age 10.63 ± 0.66 years) who served as the control. The records consisted of lateral cephalograms, dental pantomograms, and study casts. Paired t-test, analysis of variance, and chi-square tests were used to determine whether significant differences existed between the groups. In both treatment groups, the lower incisors proclined and moved forward, and space loss of the lower primary second molar occurred. The LLHA made of 0.9 mm SS was superior to that made of 1.25 mm SS in terms of arch length preservation.

  17. Resolving ethical issues in stem cell clinical trials: the example of Parkinson disease.

    Science.gov (United States)

    Lo, Bernard; Parham, Lindsay

    2010-01-01

    Clinical trials of stem cell transplantation raise ethical issues that are intertwined with scientific and design issues, including choice of control group and intervention, background interventions, endpoints, and selection of subjects. We recommend that the review and IRB oversight of stem cell clinical trials should be strengthened. Scientific and ethics review should be integrated in order to better assess risks and potential benefits. Informed consent should be enhanced by assuring that participants comprehend key aspects of the trial. For the trial to yield generalizable knowledge, negative findings and serious adverse events must be reported.

  18. Network analysis of pig movements: Loyalty patterns and contact chains of different holding types in Denmark.

    Science.gov (United States)

    Schulz, Jana; Boklund, Anette; Halasa, Tariq H B; Toft, Nils; Lentz, Hartmut H K

    2017-01-01

    Understanding animal movements is an important factor for the development of meaningful surveillance and control programs, but also for the development of disease spread models. We analysed the Danish pig movement network using static and temporal network analysis tools to provide deeper insight in the connection between holdings dealing with pigs, such as breeding and multiplier herds, production herds, slaughterhouses or traders. Pig movements, which occurred between 1st January 2006 and 31st December 2015 in Denmark, were summarized to investigate temporal trends such as the number of active holdings, the number of registered movements and the number of pigs moved. To identify holdings and holding types with potentially higher risk for introduction or spread of diseases via pig movements, we determined loyalty patterns, annual network components and contact chains for the 24 registered holding types. The total number of active holdings as well as the number of pig movements decreased during the study period while the holding sizes increased. Around 60-90% of connections between two pig holdings were present in two consecutive years and around one third of the connections persisted within the considered time period. Weaner herds showed the highest level of in-loyalty, whereas we observed an intermediate level of in-loyalty for all breeding sites and for production herds. Boar stations, production herds and trade herds showed a high level of out-loyalty. Production herds constituted the highest proportion of holdings in the largest strongly connected component. All production sites showed low levels of in-going contact chains and we observed a high level of out-going contact chain for breeding and multiplier herds. Except for livestock auctions, all transit sites also showed low levels of out-going contact chains. Our results reflect the pyramidal structure of the underlying network. Based on the considered disease, the time frame for the calculation of network

  19. Exploring & exploiting our 'other self' - does the microbiota hold the key to the future therapy in Crohn's?

    Science.gov (United States)

    Haag, Lea-Maxie; Siegmund, Britta

    2014-06-01

    Inflammatory bowel diseases (IBD) with its two major forms Crohn's disease (CD) and ulcerative colitis (UC) are chronic relapsing disorders leading to inflammation of the gastrointestinal tract. Although the precise aetiology of IBD remains unclear, several factors are believed to contribute to disease pathogenesis. Among these, the role of the intestinal microbiota has become more and more appreciated. Evidence from experimental and clinical studies strongly suggests that chronic intestinal inflammation results from a dysregulated immune response towards components of the microbiota in genetically susceptible hosts. The growing perception of the microbiota as a major driver of disease pathogenesis raises the question, if the intestinal microbiota can be used as a therapeutic target in CD. Based on what we know about host microbiota interactions in health and disease, the objective of this review is to address the question if the microbiota holds the key to the future therapy in CD.

  20. 41 CFR 102-37.115 - May a holding agency be reimbursed for costs incurred incident to a donation?

    Science.gov (United States)

    2010-07-01

    ... reimbursed for costs incurred incident to a donation? 102-37.115 Section 102-37.115 Public Contracts and... REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Holding Agency § 102-37.115 May a holding agency be reimbursed for costs incurred incident to a donation? Yes, you, as a holding agency,...

  1. 26 CFR 301.6035-1 - Returns of officers, directors, and shareholders of foreign personal holding companies.

    Science.gov (United States)

    2010-04-01

    ... shareholders of foreign personal holding companies. 301.6035-1 Section 301.6035-1 Internal Revenue INTERNAL... shareholders of foreign personal holding companies. For provisions relating to the requirement of returns by officers, directors, and shareholders of foreign personal holding companies, see §§ 1.6035-1 to...

  2. 18 CFR 292.602 - Exemption to qualifying facilities from the Public Utility Holding Company Act and certain State...

    Science.gov (United States)

    2010-04-01

    ... facilities from the Public Utility Holding Company Act and certain State law and regulation. 292.602 Section... from the Public Utility Holding Company Act and certain State law and regulation. Link to an amendment... qualifying facilities from the Public Utility Holding Company Act of 2005 and certain State laws and...

  3. 76 FR 32226 - Russell Newman, Inc., a Subsdiary of RNA Holdings, LLC, Including On-Site Leased Workers From...

    Science.gov (United States)

    2011-06-03

    ... Employment and Training Administration Russell Newman, Inc., a Subsdiary of RNA Holdings, LLC, Including On...; Russell Newman, Inc., a Subsidiary of RNA Holdings, LLC, Great Barrington, MA; RNA Holdings, LLC, a... Adjustment Assistance on March 3, 2011, applicable to workers of Russell Newman, Inc., a subsidiary of RNA...

  4. 12 CFR 225.103 - Bank holding company acquiring stock by dividends, stock splits or exercise of rights.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Bank holding company acquiring stock by... holding company acquiring stock by dividends, stock splits or exercise of rights. (a) The Board of... SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE...

  5. The Police Executive and Governance: Adapting Police Leadership to an Increase in Oversight and Accountability in Police Operations

    Directory of Open Access Journals (Sweden)

    Gary Ellis

    2014-03-01

    Full Text Available In a democracy, it is generally understood that the police serve at the will of the people and are accountable through police governance. This usually consists of elected and/or appointed officials whose primary legal authority is to set policy and appoint the police leaders whom they hold accountable for ensuring that effective policing operations are carried out. It is widely held in common law jurisdictions that the governing body is limited in their role and cannot get involved in “operational policing issues.” In June 2010, the G20 world leaders’ conference was held in Toronto, Canada. The events surrounding the police actions during this conference caused a great deal of concern and led the Toronto Police Services Board, who are the governing authority for the Toronto Police Service, to commission a review to look at their own role. The findings in relation to “board” involvement in the operational side of policing challenged a long held belief regarding the limited role of governance in police operations. These findings will be examined in relation to the lack of board expertise and the challenges faced by police leaders to adapt and develop their attitudes, skills and abilities to respond to any expansion of governance authority.

  6. Holding Water in the Landscape; striking a balance between food production and healthy catchment function

    Science.gov (United States)

    Quinn, Paul; Wilkinson, Mark; Stutter, Marc; Adams, Russell

    2015-04-01

    Here it is proposed that ~5 % of the rural landscape could be modified to hold water during storm events. Hence ~95% of land remains for food production, commercial forestry and amenity. This is a catchment scale commitment to sustainably reducing flood and drought risk, improving water quality, biodiversity and thereby climate proofing our catchments. The farmed landscape has intensified and as a result, runoff rates are no longer in balance with the catchment needs, which in turn contributes to floods, droughts and water pollution problems. The loss of infiltration rates, soil water holding capacity and the increase in ditches and drains through intense farming has resulted in a reduction of the overall water holding capacity of the landscape, therefore deeper soil and aquifer recharge rates are lower. However, adequate raw water supply and food production is also vital. Here we consider how ~5% of productive land could be used to physically hold water during and after storms. This is a simple philosophy for water stewardship that could be delivered by farmers and land managers themselves. In this poster we consider a 'treatment train' of mitigation in headwaters by the construction of:- Rural SuDs - by creating swales, bunds and grassy filters; Buffer Strips - (designed to hold water); The Ditch of The Future - by creating the prime location for holding water and recovering lost top soil and finally the better use of Small Headwater Floodplains - by storing flood water, creating wetlands, planting new forest, installing woody debris and new habitats. We present examples of where and how these measures have been installed and show the cost-effectiveness of temporarily holding storm runoff in several case study catchments taken from the UK.

  7. Analysis of the baseline survey on the prevalence of Salmonella in holdings with breeding pigs in the EU, 2008

    DEFF Research Database (Denmark)

    Bole-Hribovšek, Vojislava; Chriél, Mariann; Davies, Robert;

    Salmonella is a major cause of food-borne illness in humans. Farm animals and foods of animal origin are important sources of human Salmonella infections. This European Union-wide Salmonella baseline survey was conducted in 2008 in holdings with breeding pigs. A total of 1,609 holdings housing...... and selling mainly breeding pigs (breeding holdings) and 3,508 holdings housing breeding pigs and selling mainly pigs for fattening or slaughter (production holdings) from 24 European Union Member States and two non-Member States, were randomly selected and included in the survey. In each selected breeding...

  8. Influence of Holding Time on Shape Recovery in a Polyurethane Shape-Memory Polymer

    Science.gov (United States)

    Santiago, David; Ferrando, Francesc; De la Flor, Silvia

    2014-07-01

    Shape-memory polymers have attracted a lot of interest in recent years. A shape-memory polymer can be deformed and fixed into a temporary shape and subsequently made to recover its original shape when a suitable stimulus is applied. This is accomplished by means of a thermomechanical cycle called programming. Programming can be performed in a stress- or strain-controlled mode. The thermomechanical conditions of the programming affect shape-memory properties differently in each programming mode. One of the parameters which significantly affects shape-memory properties in a stress-controlled procedure is stress-holding time ( t H) at high temperature. This paper studies how stress-holding time affects the most significant shape-memory properties under successive thermomechanical cycles. The experiments were conducted using two different programming temperatures in the vicinity of the T g. The shape-recovery ratio decreased dramatically with cycling even when the holding time was just a few seconds, however, the impact of the stress-holding time depends on the temperature at which it has been applied. Shape-fixity ratio and switching temperature were also studied, but stress-holding time and successive cycles do not seem to affect either of these factors.

  9. Development of inclusions in 3104 alloy melt during heating and holding treatments

    Institute of Scientific and Technical Information of China (English)

    Xiao-xiong Luo; Hai-tao Zhang; Xing Han; Shi-jie Guo; Dan-dan Chen; Jian-zhong Cui; Hiromi Nagaumi

    2016-01-01

    Developments in the contents of different typical inclusions in 3104 alloy melt were described during heating and holding proc-essing. The settling process of inclusion particles was investigated by measuring the contents of inclusions in the surface, center, and bottom layers of the molten metal. In the results, main inclusions observed and determined by Prefil and PoDFA methods are MgO, Al2O3, spinel (MgAl2O4), and TiB2 particles or thin films. It is found that some small particles of Al2O3 and MgO are transformed into spinel particles, and the formation rate increases as the temperature and the holding period of melt increase. The content of inclusions increases from 3.37 mm2×kg-1 to 7.54 mm2×kg-1 and then decreases to 3.08 mm2×kg−1 after holding for 90 min. This is attributed to a settling phenomenon and a significant increase in settling velocity after holding for 60 min. The content of inclusion particles decreases by means of settlement and flo-tation in liquid aluminum with an increase in holding time. The theoretical analysis and experiment results are in essential agreement with those from industrial production.

  10. Holding time effect of pack carburizing on fatigue characteristic of v-notch shaft steel specimens

    Science.gov (United States)

    Supriyono, Jamasri

    2017-06-01

    The objective of this research is to study the effect of the holding times of pack carburizing process on fatigue characteristic of v-notch shaft steel specimens. The carbon source was taken from charcoal of unused mahogany. The holding times were 2, 3 and 4 hours. The fatigue tests were conducted on rotary bending machine. The specimens were made of low carbon steel of 0.17% carbon content. Pack carburizing was conducted to the specimens at 930°C. V-notch was made to present the stress concentration on the specimens. To see the effects of the carburizing in changing the material properties, the micro-structures and hardness tests along the cross sectional area of the specimens were carried out. The results showed that the holding time of the carburizing process influences the fatigue strength of the material. The longer the holding time will be the higher the fatigue strength. The increase of the fatigue strength is due to the carbon content on the surface. It was confirmed by the micro-structures and the hardness tests results. The cross sectional area of carburized material is divided into two zones i.e. surface zone and core zone. The surface zone consists of hypereutectoid, eutectoid, and hypo eutectoid sub-zone. The core zone is the same as raw material. The longer the holding time will be the deeper the surface zone.

  11. Progress Report on Long Hold Time Creep Fatigue of Alloy 617 at 850°C

    Energy Technology Data Exchange (ETDEWEB)

    Carroll, Laura Jill [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-10-01

    Alloy 617 is the leading candidate material for an intermediate heat exchanger for the very high temperature reactor. To evaluate the behavior of this material in the expected service conditions, strain-controlled cyclic tests that include long hold times up to 240 minutes at maximum tensile strain were conducted at 850°C. In terms of the total number of cycles to failure, the fatigue resistance decreased when a hold time was added at peak tensile strain. Increases in the tensile hold duration degraded the creep-fatigue resistance, at least to the investigated strain controlled hold time of up to 60 minutes at the 0.3% strain range and 240 minutes at the 1.0% strain range. The creep-fatigue deformation mode is considered relative to the lack of saturation, or continually decreasing number of cycles to failure with increasing hold times. Additionally, preliminary values from the 850°C creep-fatigue data are calculated for the creep-fatigue damage diagram and have higher values of creep damage than those from tests at 950°C.

  12. Control of grip force and vertical posture while holding an object and being perturbed.

    Science.gov (United States)

    Chen, Bing; Lee, Yun-Ju; Aruin, Alexander S

    2016-11-01

    We investigated motor control perspectives of coordinating maintenance of posture and application of grip force when holding an object and being perturbed. Ten subjects stood on the force platform holding an instrumented object in their dominant hand and were exposed to an external perturbation applied to their shoulders. Task demands were manipulated by positioning a slippery cap on top of the instrumented object. Grip force applied to the object, the object acceleration and the center of pressure (COP) were recorded and analyzed during the time intervals typical for the anticipatory (APA) and compensatory (CPA) components of postural control. Onsets of grip force were seen before the onsets of the COP displacement and initiation of movements of the handheld object during the APA phase of postural control, while the onsets of maximum grip force preceded the maximum COP displacement during the CPA phase. When the task demands increased by holding a handheld object with the slippery cap, subjects tended to generate grip force earlier and of a smaller magnitude; also, the COP displacement in the APA phase was smaller as compared to holding a handheld object only. The outcome provides a foundation for future studies of maintenance of vertical posture in people with impairments of balance and grip force control when holding an object and being perturbed.

  13. Effects of holding time and measurement error on culturing Legionella in environmental water samples.

    Science.gov (United States)

    Flanders, W Dana; Kirkland, Kimberly H; Shelton, Brian G

    2014-10-01

    Outbreaks of Legionnaires' disease require environmental testing of water samples from potentially implicated building water systems to identify the source of exposure. A previous study reports a large impact on Legionella sample results due to shipping and delays in sample processing. Specifically, this same study, without accounting for measurement error, reports more than half of shipped samples tested had Legionella levels that arbitrarily changed up or down by one or more logs, and the authors attribute this result to shipping time. Accordingly, we conducted a study to determine the effects of sample holding/shipping time on Legionella sample results while taking into account measurement error, which has previously not been addressed. We analyzed 159 samples, each split into 16 aliquots, of which one-half (8) were processed promptly after collection. The remaining half (8) were processed the following day to assess impact of holding/shipping time. A total of 2544 samples were analyzed including replicates. After accounting for inherent measurement error, we found that the effect of holding time on observed Legionella counts was small and should have no practical impact on interpretation of results. Holding samples increased the root mean squared error by only about 3-8%. Notably, for only one of 159 samples, did the average of the 8 replicate counts change by 1 log. Thus, our findings do not support the hypothesis of frequent, significant (≥= 1 log10 unit) Legionella colony count changes due to holding.

  14. GMI High Frequency Antenna Pattern Correction Update Based on GPM Inertial Hold and Comparison with ATMS

    Science.gov (United States)

    Draper, David W.

    2015-01-01

    In an inertial hold, the spacecraft does not attempt to maintain geodetic pointing, but rather maintains the same inertial position throughout the orbit. The result is that the spacecraft appears to pitch from 0 to 360 degrees around the orbit. Two inertial holds were performed with the GPM spacecraft: 1) May 20, 2014 16:48:31 UTC-18:21:04 UTC, spacecraft flying forward +X (0yaw), pitch from 55 degrees (FCS) to 415 degrees (FCS) over the orbit2) Dec 9, 2014 01:30:00 UTC-03:02:32 UTC, spacecraft flying backward X (180yaw), pitch from 0 degrees (FCS) to 360 degrees (FCS) over the orbitThe inertial hold affords a view of the earth through the antenna backlobe. The antenna spillover correction may be evaluated based on the inertial hold data.The current antenna pattern correction does not correct for spillover in the 166 and 183 GHz channels. The two inertial holds both demonstrate that there is significant spillover from the 166 and 183 GHz channels. By not correcting the spillover, the 166 and 183 GHz channels are biased low by about 1.8 to 3K. We propose to update the GMI calibration algorithm with the spill-over correction presented in this document for 166 GHz and 183 GHz.

  15. Mean heart dose variation over a course of breath-holding breast cancer radiotherapy.

    Science.gov (United States)

    Dunkerley, Nicolle; Bartlett, Frederick R; Kirby, Anna M; Evans, Philip M; Donovan, Ellen M

    2016-11-01

    The purpose of the work was to estimate the dose received by the heart throughout a course of breath-holding breast radiotherapy. 113 cone-beam CT (CBCT) scans were acquired for 20 patients treated within the HeartSpare 1A study, in which both an active breathing control (ABC) device and a voluntary breath-hold (VBH) method were used. Predicted mean heart doses were obtained from treatment plans. CBCT scans were imported into a treatment planning system, heart outlines defined, images registered to the CT planning scan and mean heart dose recorded. Two observers outlined two cases three times each to assess interobserver and intraobserver variation. There were no statistically significant differences between ABC and VBH heart dose data from CT planning scans, or in the CBCT-based estimates of heart dose, and no effect from the order of the breath-hold method. Variation in mean heart dose per fraction over the three imaged fractions was heart doses were heart dose was at an acceptable level over the duration of breath-holding radiotherapy and was well predicted by the planning system. Advances in knowledge: Mean heart dose was not adversely affected by fraction-to-fraction variations throughout a course of heart-sparing radiotherapy using two well-established breath-holding methods.

  16. Implications of geographical variation on clinical outcomes of cardiovascular trials.

    Science.gov (United States)

    Mentz, Robert J; Kaski, Juan-Carlos; Dan, Gheorghe-Andrei; Goldstein, Sidney; Stockbridge, Norman; Alonso-Garcia, Angeles; Ruilope, Luis M; Martinez, Felipe A; Zannad, Faiez; Pitt, Bertram; Fiuzat, Mona; O'Connor, Christopher M

    2012-09-01

    Cardiovascular clinical trials are increasingly conducted globally as a means to reduce costs, expedite timelines, provide broad applicability, and satisfy regulatory authorities. Potential problems with trial globalization include regional differences in patient characteristics, medical practice patterns, and health policies which may influence outcomes and limit generalizability. Moreover, concerns have been raised about ethical misconduct and unsatisfactory quality oversight in regions with less trial experience and infrastructure. This article reviews geographical differences in cardiovascular trials in heart failure, acute coronary syndromes, hypertension and atrial fibrillation. It also explores potential explanations for these differences and methods to standardize the presentation of trial results. This review is based on discussions between basic scientists and clinical trialists at the 8th Global Cardio Vascular Clinical Trialists Forum 2011 in Paris, France, from December 2 to 3. Copyright © 2012 Mosby, Inc. All rights reserved.

  17. Single breath-hold assessment of cardiac function using an accelerated 3D single breath-hold acquisition technique - comparison of an intravascular and extravascular contrast agent

    Directory of Open Access Journals (Sweden)

    Makowski Marcus R

    2012-07-01

    Full Text Available Abstract Background Cardiovascular magnetic resonance (CMR is the current gold standard for the assessment of left ventricular (LV function. Repeated breath-holds are needed for standard multi-slice 2D cine steady-state free precession sequences (M2D-SSFP. Accelerated single breath-hold techniques suffer from low contrast between blood pool and myocardium. In this study an intravascular contrast agent was prospectively compared to an extravascular contrast agent for the assessment of LV function using a single-breath-hold 3D-whole-heart cine SSFP sequence (3D-SSFP. Methods LV function was assessed in fourteen patients on a 1.5 T MR-scanner (Philips Healthcare using 32-channel coil technology. Patients were investigated twice using a 3D-SSFP sequence (acquisition time 18–25 s after Gadopentetate dimeglumine (GdD, day 1 and Gadofosveset trisodium (GdT, day 2 administration. Image acquisition was accelerated using sensitivity encoding in both phase encoding directions (4xSENSE. CNR and BMC were both measured between blood and myocardium. The CNR incorporated noise measurements, while the BMC represented the coeffiancy between the signal from blood and myocardium [1]. Contrast to noise ratio (CNR, blood to myocardium contrast (BMC, image quality, LV functional parameters and intra-/interobserver variability were compared. A M2D-SSFP sequence was used as a reference standard on both days. Results All 3D-SSFP sequences were successfully acquired within one breath-hold after GdD and GdT administration. CNR and BMC were significantly (p vs. 23.7 and regression analysis showed a stronger correlation to the reference standard (R2 = 0.92 vs. R2 = 0.71, compared to 3D-SSFP with GdD. Conclusions A single-breath-hold 3D-whole-heart cine SSFP sequence in combination with 32-channel technology and an intravascular contrast agent allows for the accurate and fast assessment of LV function. Trial registration The study was approved by the local

  18. The effect of holding times of whole blood and its components during processing on in vitro and in vivo quality.

    Science.gov (United States)

    van der Meer, Pieter F; de Korte, Dirk

    2015-01-01

    Whole blood is not usually collected close to the processing site, which results in a holding time between collection and processing. In some countries, the holding time is limited to 8 hours, after which the units are cooled, rendering them useless for platelet preparation. Other countries allow a 24-hour (“overnight”) ambient hold to allow platelet preparation. The impact of this holding time on subsequent blood components will be reviewed in this article. In addition, there are various “in-process” holding times that further prolong the time before the final blood component is ready. Particularly, these in-process holding times are not well defined and poorly controlled,but can nevertheless affect the biochemical and functional characteristics of blood components. Furthermore, current, non–evidence-based, guidelines have restricted the length of some of these holding times. This article summarizes the evidence and fills gaps where evidence is lacking.

  19. Hold fast!

    DEFF Research Database (Denmark)

    Pedersen, Michael Svendsen

    Publikationen indeholder en kort præsentation af resultaterne fra en række initiativer for tosprogede og praktisk orienterede elever i erhvervsuddannelserne med henblik på at fastholde dem i uddannelse....

  20. Optimization Techniques for Source Follower Based Track-and-Hold Circuit for High Speed Wireless Communication

    Directory of Open Access Journals (Sweden)

    Manoj Kumar

    2011-03-01

    Full Text Available Since the current demand for high need for track and hold amplifiers (T&H operating at RF frequencies. A circuit is the key element in any modern wide band data acquisition system. Applications like a cable or a broad variety of different radio standards require high processing speeds with high resolution. The track-and-hold (T&H circuit is a fundamental block for analog allows most dynamic errors of A/D converters to be reduced, especially those showing up when using high frequency input signals. Having a wide band and precise acquisition system today’s trend towards multi-standard flexible radios, with as much signal processing as possible in digital domain. This work investigates effect of various design schemes and circuit topology for track and-hold circuit to achieve acceptable linearly, high slew rate, low power consumption and low noise