Clinical laboratories collaborate to resolve differences in variant interpretations submitted to ClinVar.

Science.gov (United States)

Harrison, Steven M; Dolinsky, Jill S; Knight Johnson, Amy E; Pesaran, Tina; Azzariti, Danielle R; Bale, Sherri; Chao, Elizabeth C; Das, Soma; Vincent, Lisa; Rehm, Heidi L

2017-10-01

Data sharing through ClinVar offers a unique opportunity to identify interpretation differences between laboratories. As part of a ClinGen initiative, four clinical laboratories (Ambry, GeneDx, Partners Healthcare Laboratory for Molecular Medicine, and University of Chicago Genetic Services Laboratory) collaborated to identify the basis of interpretation differences and to investigate if data sharing and reassessment resolve interpretation differences by analyzing a subset of variants. ClinVar variants with submissions from at least two of the four participating laboratories were compared. For a subset of identified differences, laboratories documented the basis for discordance, shared internal data, independently reassessed with the American College of Medical Genetics and Genomics-Association for Molecular Pathology (ACMG-AMP) guidelines, and then compared interpretations. At least two of the participating laboratories interpreted 6,169 variants in ClinVar, of which 88.3% were initially concordant. Laboratories reassessed 242/724 initially discordant variants, of which 87.2% (211) were resolved by reassessment with current criteria and/or internal data sharing; 12.8% (31) of reassessed variants remained discordant owing to differences in the application of the ACMG-AMP guidelines. Participating laboratories increased their overall concordance from 88.3 to 91.7%, indicating that sharing variant interpretations in ClinVar-thereby allowing identification of differences and motivation to resolve those differences-is critical to moving toward more consistent variant interpretations.Genet Med advance online publication 09 March 2017.

Towards an automatic model transformation mechanism from UML state machines to DEVS models

Directory of Open Access Journals (Sweden)

Ariel González

2015-08-01

Full Text Available The development of complex event-driven systems requires studies and analysis prior to deployment with the goal of detecting unwanted behavior. UML is a language widely used by the software engineering community for modeling these systems through state machines, among other mechanisms. Currently, these models do not have appropriate execution and simulation tools to analyze the real behavior of systems. Existing tools do not provide appropriate libraries (sampling from a probability distribution, plotting, etc. both to build and to analyze models. Modeling and simulation for design and prototyping of systems are widely used techniques to predict, investigate and compare the performance of systems. In particular, the Discrete Event System Specification (DEVS formalism separates the modeling and simulation; there are several tools available on the market that run and collect information from DEVS models. This paper proposes a model transformation mechanism from UML state machines to DEVS models in the Model-Driven Development (MDD context, through the declarative QVT Relations language, in order to perform simulations using tools, such as PowerDEVS. A mechanism to validate the transformation is proposed. Moreover, examples of application to analyze the behavior of an automatic banking machine and a control system of an elevator are presented.

A qualitative study of DevOps usage in practice

NARCIS (Netherlands)

Erich, F.M.A.; Amrit, Chintan Amrit; Daneva, Maya

Organizations are introducing agile and lean software development techniques in operations to increase the pace of their software development process and to improve the quality of their software. They use the term DevOps, a portmanteau of development and operations, as an umbrella term to describe

The GenDev Curriculum Development Workshop.

Science.gov (United States)

D'cunha, J

1997-01-01

This article describes the second Curriculum Development Workshop held in May 1997 at the Asian Institute of Technology (AIT) in Bangkok, Thailand. The workshop aimed to review critically and restructure the Gender and Development Studies (GenDev) curriculum and to assess AIT's role in training gender experts for the region. Participants included 22 people from 16 countries in Asia, Europe, and the US who were teaching graduate students about gender issues and who were activists with nongovernmental organizations working on gender issues. It was determined that the following were required courses: Culture, Knowledge and Gender Relations; Gender, Technology, and Development; Principles of Gender Research and Methodology in Science and Technology; and Gender Analysis and Field Methods. Other suggested core courses included: Gender and Natural Resource Management; Enterprise Management, Technology, and Gender; Gender and Agrarian Reform; Urbanization: A Gender Perspective; Gender-Responsive Development Planning; and Gender and Economic Change: Past and Present Concerns. Participants distinguished between GenDev courses offered to anyone attending AIT and training courses designed to produce gender experts in the region. The aim of training courses for AIT graduate students was to sensitize potential managers, technologists, and others on gender issues and to create awareness of the importance of including gender perspectives within decision-making, policy formation, and implementation. Training courses to produce gender experts should be directed to those with a prior background in gender studies and include gender analysis in field methods. Participants agreed that there should be an independent and autonomous field of gender and development studies. Participants made six recommendations for such a field of study.

Quando a Escritura devém palavra

OpenAIRE

Cardita, Ângelo

2009-01-01

O estudo que se segue é uma primeira tentativa de traçar um caminho, em grande parte já aberto como veremos, passando pela «teologia litúrgica». O objectivo não é tanto demonstrar que na liturgia, na passagem do texto à voz, a escritura devém palavra e mais profundamente palavra de Deus, mas arguir a pertinência de uma tal hipótese, como forma de inter-relacionar teologia bíblica e teologia litúrgica, numa teologia da palavra.

An Approach for the Implementation of Software Quality Models Adpoting CERTICS and CMMI-DEV

Directory of Open Access Journals (Sweden)

GARCIA, F.W.

2015-12-01

Full Text Available This paper proposes a mapping between two product quality and software processes models used in the industry, the CERTICS national model and the CMMI-DEV international model. The stages of mapping are presented step by step, as well as the mapping review, which had the cooperation of one specialist in CERTICS and CMMI-DEV models. It aims to correlate the structures of the two models in order to facilitate and reduce the implementation time and costs, and to stimulate the execution of multi-model implementations in software developers companies.

Convergence Analysis of ISO/IEC 12207 and CMMI-DEV: Complementary Result from Systematic Literature Review

Directory of Open Access Journals (Sweden)

Javier Crisóstomo

2017-12-01

Full Text Available The organizations and people are demanding more and better software products and services, which implies adequate processes for its development. In the context of the software industry, there are two models, the CMMI-DEV and ISO/IEC 12207 that are influencing it. Though, they are evolving separately, recurrently they have been compared to determine its coverage (in both directions. In this study is analyzed the results of those comparisons (partials and completed to determine if the models ISO/IEC 12207 and CMMI-DEV converge at processes level. This study identified eight articles where the comparison is carried out between ISO/IEC 12207 and CMMI-DEV. The results show that technique most used is the mapping comparisons between the models and according to the analyzed studies is not possible to determine whether there is convergence in the time. However, we found some items and criterions for use in comparisons.

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International Development Research Centre (IDRC) Digital Library (Canada)

IDRC funding for SciDev.Net (SDN), will enhance the not-for profit organization's ability to provide reliable and authoritative information about science and technology in the developing world as it transitions to a self-sustaining business. The funding will continue to support SDN's service and capacity-building activities, ...

UML Modeling for Dynamic Logistics System Based on DEVS

OpenAIRE

Zhang Zhiyong; Liu Jie; Zhang Xinhui

2013-01-01

DEVS is a hierarchical and modular system descriptive method. However, it cannot describe dynamic process and relationship of system members. This article has proposed a way to extend UML using stereotype, making it suitable for simulation modeling. To build a modeling tool, we defined atomic model class and coupled model class, both of which are in line with not only DEVS’s hierarchical and modular requirements but also UML’s object-oriented characteristics. At last, we use the tool to analy...

imDEV: a graphical user interface to R multivariate analysis tools in Microsoft Excel

Science.gov (United States)

Interactive modules for data exploration and visualization (imDEV) is a Microsoft Excel spreadsheet embedded application providing an integrated environment for the analysis of omics data sets with a user-friendly interface. Individual modules were designed to provide toolsets to enable interactive ...

Teaching DevOps and Cloud Computing using a Cognitive Apprenticeship and Story-Telling Approach

DEFF Research Database (Denmark)

Christensen, Henrik Bærbak

2016-01-01

DevOps is a new way of developing software that is challenging from a teaching perspective. In this paper, we outline these challenges and propose teaching methods that focus on skill acquisition and technical practices that focus on performant virtualization to overcome them. We describe central...

Microservices Architecture Enables DevOps: an Experience Report on Migration to a Cloud-Native Architecture

OpenAIRE

Balalaie, A; Heydarnoori, A; Jamshidi Dermani, P

2016-01-01

This article reports on experiences and lessons learned during incremental migration and architectural refactoring of a commercial mobile back end as a service to microservices architecture. It explains how the researchers adopted DevOps and how this facilitated a smooth migration.

DevOps y análisis de performance automáticos

OpenAIRE

Olmedo Rodríguez, Álvaro

2018-01-01

Se tratará de hacer hincapié en el campo de los tests de performance y análisis de rendimiento de sistemas productivos, más concretamente en el despliegue de estos. Todo ello dentro del marco de la nueva metodología o filosofía organizativa conocida como DevOps, centrándose, por tanto, mucho más en la parte de Operaciones dentro de dicha filosofía. Esta filosofía, que trata de reducir la distancia entre los grupos de desarrollo y operaciones tiene algunos aspectos como la integración y ...

Supporting Collaborative Model and Data Service Development and Deployment with DevOps

Science.gov (United States)

David, O.

2016-12-01

Adopting DevOps practices for model service development and deployment enables a community to engage in service-oriented modeling and data management. The Cloud Services Integration Platform (CSIP) developed the last 5 years at Colorado State University provides for collaborative integration of environmental models into scalable model and data services as a micro-services platform with API and deployment infrastructure. Originally developed to support USDA natural resource applications, it proved suitable for a wider range of applications in the environmental modeling domain. While extending its scope and visibility it became apparent community integration and adequate work flow support through the full model development and application cycle drove successful outcomes.DevOps provide best practices, tools, and organizational structures to optimize the transition from model service development to deployment by minimizing the (i) operational burden and (ii) turnaround time for modelers. We have developed and implemented a methodology to fully automate a suite of applications for application lifecycle management, version control, continuous integration, container management, and container scaling to enable model and data service developers in various institutions to collaboratively build, run, deploy, test, and scale services within minutes.To date more than 160 model and data services are available for applications in hydrology (PRMS, Hydrotools, CFA, ESP), water and wind erosion prediction (WEPP, WEPS, RUSLE2), soil quality trends (SCI, STIR), water quality analysis (SWAT-CP, WQM, CFA, AgES-W), stream degradation assessment (SWAT-DEG), hydraulics (cross-section), and grazing management (GRAS). In addition, supporting data services include soil (SSURGO), ecological site (ESIS), climate (CLIGEN, WINDGEN), land management and crop rotations (LMOD), and pesticides (WQM), developed using this workflow automation and decentralized governance.

Convergence Analysis of ISO/IEC 12207 and CMMI-DEV: Complementary Result from Systematic Literature Review

OpenAIRE

Javier Crisóstomo; Karin Melendez; Luis Flores; Abraham Dávila

2017-01-01

The organizations and people are demanding more and better software products and services, which implies adequate processes for its development. In the context of the software industry, there are two models, the CMMI-DEV and ISO/IEC 12207 that are influencing it. Though, they are evolving separately, recurrently they have been compared to determine its coverage (in both directions). In this study is analyzed the results of those comparisons (partials and completed) to determine if the models ...

Genotype-driven identification of a molecular network predictive of advanced coronary calcium in ClinSeq® and Framingham Heart Study cohorts.

Science.gov (United States)

Oguz, Cihan; Sen, Shurjo K; Davis, Adam R; Fu, Yi-Ping; O'Donnell, Christopher J; Gibbons, Gary H

2017-10-26

One goal of personalized medicine is leveraging the emerging tools of data science to guide medical decision-making. Achieving this using disparate data sources is most daunting for polygenic traits. To this end, we employed random forests (RFs) and neural networks (NNs) for predictive modeling of coronary artery calcium (CAC), which is an intermediate endo-phenotype of coronary artery disease (CAD). Model inputs were derived from advanced cases in the ClinSeq®; discovery cohort (n=16) and the FHS replication cohort (n=36) from 89 th -99 th CAC score percentile range, and age-matched controls (ClinSeq®; n=16, FHS n=36) with no detectable CAC (all subjects were Caucasian males). These inputs included clinical variables and genotypes of 56 single nucleotide polymorphisms (SNPs) ranked highest in terms of their nominal correlation with the advanced CAC state in the discovery cohort. Predictive performance was assessed by computing the areas under receiver operating characteristic curves (ROC-AUC). RF models trained and tested with clinical variables generated ROC-AUC values of 0.69 and 0.61 in the discovery and replication cohorts, respectively. In contrast, in both cohorts, the set of SNPs derived from the discovery cohort were highly predictive (ROC-AUC ≥0.85) with no significant change in predictive performance upon integration of clinical and genotype variables. Using the 21 SNPs that produced optimal predictive performance in both cohorts, we developed NN models trained with ClinSeq®; data and tested with FHS data and obtained high predictive accuracy (ROC-AUC=0.80-0.85) with several topologies. Several CAD and "vascular aging" related biological processes were enriched in the network of genes constructed from the predictive SNPs. We identified a molecular network predictive of advanced coronary calcium using genotype data from ClinSeq®; and FHS cohorts. Our results illustrate that machine learning tools, which utilize complex interactions between disease

Franšīzes devēju un franšīzes ņēmēju konfliktu izraisošie faktori

OpenAIRE

Iļjenko, Ivonna

2015-01-01

Maģistra darba nosaukums ir „Franšīzes devēju un franšīzes ņēmēju konfliktu izraisošie faktori”. Maģistra darba mērķis ir identificēt būtiskākos konfliktu izraisošos faktorus franšīzes devēju un franšīzes ņēmēju attiecībās, raksturot franšīzes praktisko pielietojumu un izstrādāt priekšlikumus franšīzes popularizēšanai un konfliktu novēršanai franšīzes attiecībās Latvijā. Darba pirmajā nodaļā raksturota franšīzes būtība, tās priekšrocības un trūkumi, konflikta process, konfliktu izraisošie...

IEEE Std 730 Software Quality Assurance: Supporting CMMI-DEV v1.3, Product and Process Quality Assurance

Science.gov (United States)

2011-05-27

frameworks 4 CMMI-DEV IEEE / ISO / IEC 15288 / 12207 Quality Assurance ©2011 Walz IEEE Life Cycle Processes & Artifacts • Systems Life Cycle Processes...TAG to ISO TC 176 Quality Management • Quality: ASQ, work experience • Software: three books, consulting, work experience • Systems: Telecom & DoD...and IEEE 730 SQA need to align. The P730 IEEE standards working group has expanded the scope of the SQA process standard to align with IS 12207

Modelo Aplicable A La Gestión De Procesos Ágiles De Desarrollo De Software Basado En Cmmi –Dev 1.3 Y Scrum

Directory of Open Access Journals (Sweden)

Adriana Iglesias

2015-01-01

Full Text Available El presente Artículo de Investigación propone un modelo orientado a las necesidades de calidad total en las organizaciones dedicadas al desarrollo de software conforme a la alineación de los procesos de desarrollo y gestión con los objetivos organizacionales; lo cual hace pertinente la formulación de un modelo de gestión de procesos de desarrollo basado en los principios y prácticas del enfoque ágil, orientado hacia la aplicación de buenas prácticas y procesos de mejora continua. El modelo planteado se denomina SUMM - “Modelo Unificado de Madurez de Scrum” y está orientado a la gestión de procesos ágiles de desarrollo de software enmarcados en las buenas prácticas de CMMI-DEV 1.3 y el marco de trabajo de SCRUM. SUMM consta de cinco niveles de madurez, de acuerdo a la representación por etapas de CMMI - DEV, estos niveles a su vez están compuestos de Metas, Objetivos, Prácticas e Indicadores que permitirán a la organización poder emplear un modelo de desarrollo ágil de calidad, enfocados en procesos de mejora continua. Abstract This article of Research proposes a model oriented to the needs of total quality in organizations dedicated to software development according to the alignment of development and management processes with organizational objectives, which makes the formulation of relevant management model development process based on the principles and practices of agile approach towards the application of best practices and continuous improvement processes. The proposed model is called SUMM - "Unified Model Scrum Maturity" and is focused on process management software development agile framed in the best practices of CMMI-DEV 1.3 and SCRUM framework. SUMM consists of five maturity levels, according to the staged representation of CMMI - DEV, these levels in turn are composed of Goals, Objectives, Practices and indicators that enable the organization to employ an agile development model quality focused on continuous

Identificando Hallazgos de Mejora en Pymes de TI Utilizando un Modelo Ontológico para CMMI-DEV v1.3

Directory of Open Access Journals (Sweden)

J. Guadalupe Uribe Dévora

2013-12-01

Full Text Available Uno de los principales requisitos que deben cumplir las pymes de desarrollo de software es adoptar un estándar o modelo para garantizar la calidad de sus productos. Sin embargo, este tipo de organización, carece o no tienen procesos bien definidos. En este contexto implementar un modelo o estándar de calidad para estas organizaciones enfrenta algunos obstáculos como: gran desconocimiento sobre éstos, su adopción representa una curva de aprendizaje prolongado, las certificaciones de estos modelos o estándares para las pymes y su personal representan costos muy elevados. Por lo tanto, en este artículo se presenta una herramienta ontológica basada en el Modelo CMMI-DEV v1.3. El objetivo principal es proveer a las pymes de una herramienta que contraste sus procesos actuales obtenidos a través de un método para la extracción del conocimiento tácito versus los procesos de CMMI-DEV v1.3 para detectar posibles hallazgos de mejora e implementar mejoras en sus procesos organizacionales.

Proceedings of the INCO-DEV International Workshop on Policy Options for the Sustainable Use of Coral Reefs and Associated Ecosystems

OpenAIRE

2001-01-01

The present report contains the proceedings of the INCO-DEV International Workshop on “Policy Options for the Sustainable Use of Coral Reefs and Associated Ecosystems” convened in Mombasa, Kenya, 19-22 June 2000. It was convened to address issues associated with the ongoing degradation of coral reefs and associated ecosystems. This degradation takes place inspite of an impressing body of research results and and increasing number of technical solutions becoming available. Policy ...

imDEV: a graphical user interface to R multivariate analysis tools in Microsoft Excel.

Science.gov (United States)

Grapov, Dmitry; Newman, John W

2012-09-01

Interactive modules for Data Exploration and Visualization (imDEV) is a Microsoft Excel spreadsheet embedded application providing an integrated environment for the analysis of omics data through a user-friendly interface. Individual modules enables interactive and dynamic analyses of large data by interfacing R's multivariate statistics and highly customizable visualizations with the spreadsheet environment, aiding robust inferences and generating information-rich data visualizations. This tool provides access to multiple comparisons with false discovery correction, hierarchical clustering, principal and independent component analyses, partial least squares regression and discriminant analysis, through an intuitive interface for creating high-quality two- and a three-dimensional visualizations including scatter plot matrices, distribution plots, dendrograms, heat maps, biplots, trellis biplots and correlation networks. Freely available for download at http://sourceforge.net/projects/imdev/. Implemented in R and VBA and supported by Microsoft Excel (2003, 2007 and 2010).

AOX determination in industrial waste water according to EN 1485, DEV H14. Experience with high salt freights and interfering organic matter; AOX-Bestimmungen in Industrieabwaessern nach EN 1485, DEV H14 Erfahrungen mit hohen Salzfrachten und organischen Stoerstoffen

Energy Technology Data Exchange (ETDEWEB)

Helmreich, B. [Technische Univ. Muenchen, Garching (Germany). Lehrstuhl und Pruefamt fuer Wasserguete- und Abfallwirtschaft

1999-07-01

AOX determination in industrial waste water is not always trivial on account of high salt freights or high organic loads. Interfering substances of inorganic or organic nature can cause increases or decreases of readings that often are not plausible or reproducible. In most cases the AOX enrichment step is limiting to quantitative analysis. In the present work, enrichment in two industrial waste waters was critically assessed according to EN 1485 DEV H14. In addition, experience with the enrichment method according to Dr. Lange is reported. For the elimination of high salt freights beside a low organic concentration, cleanup by means of solid-phase extraction is considered. The results suggest that the standardized procedure is not universally applicable to any type of sample. However, appropriate action can minimize flaws of enrichment and, thereby, AOX determination. (orig.) [German] Die AOX-Bestimmung aus Industrieabwaessern ist aufgrund hoher Salzfrachten oder hoher organischer Belastungen nicht immer trivial. Stoerstoffe anorganischer wie auch organischer Art koennen zu Mehr- oder Minderbefunden fuehren, die oft nicht plausibel und reproduzierbar sind. In den meisten Faellen ist der Anreicherungsschritt des AOX fuer die quantitative Analyse limitierend. In der vorliegenden Arbeit wurde die Anreicherung nach den EN 1485 DEV H14 fuer zwei Industrieabwaesser kritisch betrachtet. Zudem werden Erfahrungen mit der Anreicherungsmethode nach Dr. Lange vorgestellt. Zur Entfernung hoher Salzfrachten neben einer geringen organischen Konzentration wurde ein Clean-up mittels Festphasenextraktion betrachtet. Die Ergebnisse legen nahe, dass das genormte Verfahren nicht universell auf jeden Probentyp anwendbar ist. Durch ein gezieltes Vorgehen koennen jedoch Fehler bei der Anreicherung und damit bei der AOX-Bestimmung minimiert werden. (orig.)

DevLore - A Firmware Library and Web-Based Configuration Control Tool for Accelerator Systems Under Constant Development

International Nuclear Information System (INIS)

Richard Evans; Kevin Jordan; Deborah Gruber; Daniel Sexton

2005-01-01

The Free Electron Laser Project at Jefferson Lab is based on a comparatively small accelerator driver. As it's systems continues to grow and evolve, strict configuration control has not been a programmatic goal. Conversely, as the IR-Demo FEL and the 10kW IR FEL have been built and operated, hardware and software changes have been regular part of the machine development process. With relatively small component counts for sub-systems, changes occur without requiring much formal documentation and in-situ alterations are common-place in the name of supporting operations. This paper presents an overview of the web-based software tool called DevLore which was first developed to be a library for embedded programming and then became a tremendously effective tool for tracking all changes made to the machine hardware and software

imDEV: a graphical user interface to R multivariate analysis tools in Microsoft Excel

Science.gov (United States)

Grapov, Dmitry; Newman, John W.

2012-01-01

Summary: Interactive modules for Data Exploration and Visualization (imDEV) is a Microsoft Excel spreadsheet embedded application providing an integrated environment for the analysis of omics data through a user-friendly interface. Individual modules enables interactive and dynamic analyses of large data by interfacing R's multivariate statistics and highly customizable visualizations with the spreadsheet environment, aiding robust inferences and generating information-rich data visualizations. This tool provides access to multiple comparisons with false discovery correction, hierarchical clustering, principal and independent component analyses, partial least squares regression and discriminant analysis, through an intuitive interface for creating high-quality two- and a three-dimensional visualizations including scatter plot matrices, distribution plots, dendrograms, heat maps, biplots, trellis biplots and correlation networks. Availability and implementation: Freely available for download at http://sourceforge.net/projects/imdev/. Implemented in R and VBA and supported by Microsoft Excel (2003, 2007 and 2010). Contact: John.Newman@ars.usda.gov Supplementary Information: Installation instructions, tutorials and users manual are available at http://sourceforge.net/projects/imdev/. PMID:22815358

Tuberculosis among people living with HIV/AIDS in the German ClinSurv HIV Cohort: long-term incidence and risk factors.

Science.gov (United States)

Karo, Basel; Haas, Walter; Kollan, Christian; Gunsenheimer-Bartmeyer, Barbara; Hamouda, Osamah; Fiebig, Lena

2014-03-19

Tuberculosis (TB) still presents a leading cause of morbidity and mortality among people living with HIV/AIDS (PLWHA), including those on antiretroviral therapy. In this study, we aimed to determine the long-term incidence density rate (IDR) of TB and risk factors among PLWHA in relation to combination antiretroviral therapy (cART)-status. Data of PLWHA enrolled from 2001 through 2011 in the German ClinSurv HIV Cohort were investigated using survival analysis and Cox regression. TB was diagnosed in 233/11,693 PLWHA either at enrollment (N = 62) or during follow-up (N = 171). The TB IDR during follow-up was 0.37 cases per 100 person-years (PY) overall [95% CI, 0.32-0.43], and was higher among patients who never started cART and among patients originating from Sub-Saharan Africa (1.23 and 1.20 per 100PY, respectively). In two multivariable analyses, both patients (I) who never started cART and (II) those on cART shared the same risk factors for TB, namely: originating from Sub-Saharan Africa compared to Germany (I, hazard ratio (HR); [95% CI]) 4.05; [1.87-8.78] and II, HR 5.15 [2.76-9.60], CD4+ cell count 5 log10 copies/ml (I, HR 2.51 [1.33-4.75] and II, HR 1.77 [1.11-2.82]). Gender, age or HIV-transmission risk group were not independently associated with TB. In the German ClinSurv HIV cohort, patients originating from Sub-Saharan Africa, with low CD4+ cell count or high viral load at enrollment were at increased risk of TB even after cART initiation. As patients might be latently infected with Mycobacterium tuberculosis complex, early screening for latent TB infection and implementing isoniazid preventive therapy in line with available recommendations is crucial.

Profesionālā sociālā tīkla LinkedIn izmantojums Latvijā: darba devēju un darba ņēmēju lietošanas motivācijas analīze

OpenAIRE

Jaunzeme, Maija

2013-01-01

Bakalaura tēma ir „Profesionālā sociālā tīkla LinkedIn izmantojums Latvijā: darba devēju un darba ņēmēju lietošanas motivācijas analīze”. Darba mērķis ir noskaidrot darba ņēmēja un darba devēja motīvus sociālā tīkla LinkedIn izmantošanai. Problēmjautājums bija noskaidrot, kā tīkls maina lietošanas paradumus lietotājam, meklējot darba vietu vai darbinieku? Teorētiskajā daļā tika analizēta lietojuma un apmierinājuma teorija sociālajiem tīkliem un LinkedIn auditorijai. Ar aptaujas palīdzību t...

Modeling the Syn-Disposition of Nitrogen Donors in Non-Heme Diiron Enzymes. Synthesis, Characterization, and Hydrogen Peroxide Reactivity of Diiron(III) Complexes with the Syn N-Donor Ligand H2BPG2DEV

Science.gov (United States)

Friedle, Simone; Kodanko, Jeremy J.; Morys, Anna J.; Hayashi, Takahiro; Moënne-Loccoz, Pierre; Lippard, Stephen J.

2009-01-01

In order to model the syn disposition of histidine residues in carboxylate-bridged non-heme diiron enzymes, we prepared a new dinucleating ligand, H2BPG2DEV, that provides this geometric feature. The ligand incorporates biologically relevant carboxylate functionalities, which have not been explored as extensively as nitrogen-only analogs. Three novel oxo-bridged diiron(III) complexes [Fe2(μ-O)(H2O)2-(BPG2DEV)](ClO4)2 (6), [Fe2(μ-O)(μ-O CAriPrO)(BPG2DEV)](ClO4) (7), and [Fe2(μ-O)(μ-CO3)(BPG2DEV)] (8) were prepared. Single crystal X-ray structural characterization confirms that two pyridines are bound syn with respect to the Fe–Fe vector in these compounds. The carbonato-bridged complex 8 forms quantitatively from 6 in a rapid reaction with gaseous CO2 in organic solvents. A common maroon-colored intermediate (λmax = 490 nm; ε = 1500 M−1 cm−1) forms in reactions of 6, 7, or 8 with H2O2 and NEt3 in CH3CN/H2O solutions. Mass spectrometric analyses of this species, formed using 18O-labeled H2O2, indicate the presence of a peroxide ligand bound to the oxo-bridged diiron(III) center. The Mössbauer spectrum at 90 K of the EPR-silent intermediate exhibits a quadrupole doublet with δ. = 0.58 mm/s and ΔEQ = 0.58 mm/s. The isomer shift is typical for a peroxodiiron(III) species, but the quadrupole splitting parameter is unusually small compared to related complexes. These Mössbauer parameters are comparable to those observed for a peroxo intermediate formed in the reaction of reduced toluene/o-xylene monooxygenase hydroxylase (ToMOH) with dioxygen. Resonance Raman studies reveal an unusually low-energy O–O stretching mode in the peroxo intermediate that is consistent with a short diiron distance. Although peroxodiiron(III) intermediates generated from 6, 7, and 8 are poor O-atom transfer catalysts, they display highly efficient catalase activity, with turnover numbers up to 10,000. In contrast to hydrogen peroxide reactions of diiron(III) complexes that lack

Calculation of direct antiretroviral treatment costs and potential cost savings by using generics in the German HIV ClinSurv cohort.

Directory of Open Access Journals (Sweden)

Matthias Stoll

Full Text Available UNLABELLED: BACKGROUND/AIM OF THE STUDY: The study aimed to determine the cost impacts of antiretroviral drugs by analysing a long-term follow-up of direct costs for combined antiretroviral therapy, cART, -regimens in the nationwide long-term observational multi-centre German HIV ClinSurv Cohort. The second aim was to develop potential cost saving strategies by modelling different treatment scenarios. METHODS: Antiretroviral regimens (ART from 10,190 HIV-infected patients from 11 participating ClinSurv study centres have been investigated since 1996. Biannual data cART-initiation, cART-changes, surrogate markers, clinical events and the Centre of Disease Control- (CDC-stage of HIV disease are reported. Treatment duration was calculated on a daily basis via the documented dates for the beginning and end of each antiretroviral drug treatment. Prices were calculated for each individual regimen based on actual office sales prices of the branded pharmaceuticals distributed by the license holder including German taxes. RESULTS: During the 13-year follow-up period, 21,387,427 treatment days were covered. Cumulative direct costs for antiretroviral drugs of €812,877,356 were determined according to an average of €42.08 per day (€7.52 to € 217.70. Since cART is widely used in Germany, the costs for an entire regimen increased by 13.5%. Regimens are more expensive in the advanced stages of HIV disease. The potential for cost savings was calculated using non-nucleotide-reverse-transcriptase-inhibitor, NNRTI, more frequently instead of ritonavir-boosted protease inhibitor, PI/r, in first line therapy. This calculation revealed cumulative savings of 10.9% to 19.8% of daily treatment costs (50% and 90% substitution of PI/r, respectively. Substituting certain branded drugs by generic drugs showed potential cost savings of between 1.6% and 31.8%. CONCLUSIONS: Analysis of the data of this nationwide study reflects disease-specific health services research

Calculation of direct antiretroviral treatment costs and potential cost savings by using generics in the German HIV ClinSurv cohort.

Science.gov (United States)

Stoll, Matthias; Kollan, Christian; Bergmann, Frank; Bogner, Johannes; Faetkenheuer, Gerd; Fritzsche, Carlos; Hoeper, Kirsten; Horst, Heinz-August; van Lunzen, Jan; Plettenberg, Andreas; Reuter, Stefan; Rockstroh, Jürgen; Stellbrink, Hans-Jürgen; Hamouda, Osamah; Bartmeyer, Barbara

2011-01-01

BACKGROUND/AIM OF THE STUDY: The study aimed to determine the cost impacts of antiretroviral drugs by analysing a long-term follow-up of direct costs for combined antiretroviral therapy, cART, -regimens in the nationwide long-term observational multi-centre German HIV ClinSurv Cohort. The second aim was to develop potential cost saving strategies by modelling different treatment scenarios. Antiretroviral regimens (ART) from 10,190 HIV-infected patients from 11 participating ClinSurv study centres have been investigated since 1996. Biannual data cART-initiation, cART-changes, surrogate markers, clinical events and the Centre of Disease Control- (CDC)-stage of HIV disease are reported. Treatment duration was calculated on a daily basis via the documented dates for the beginning and end of each antiretroviral drug treatment. Prices were calculated for each individual regimen based on actual office sales prices of the branded pharmaceuticals distributed by the license holder including German taxes. During the 13-year follow-up period, 21,387,427 treatment days were covered. Cumulative direct costs for antiretroviral drugs of €812,877,356 were determined according to an average of €42.08 per day (€7.52 to € 217.70). Since cART is widely used in Germany, the costs for an entire regimen increased by 13.5%. Regimens are more expensive in the advanced stages of HIV disease. The potential for cost savings was calculated using non-nucleotide-reverse-transcriptase-inhibitor, NNRTI, more frequently instead of ritonavir-boosted protease inhibitor, PI/r, in first line therapy. This calculation revealed cumulative savings of 10.9% to 19.8% of daily treatment costs (50% and 90% substitution of PI/r, respectively). Substituting certain branded drugs by generic drugs showed potential cost savings of between 1.6% and 31.8%. Analysis of the data of this nationwide study reflects disease-specific health services research and will give insights into the cost impacts of

Interlaboratory control among INCO-DEV MYCOTOX PROJECT LABORATORIES

Directory of Open Access Journals (Sweden)

E.A Vargas

2011-04-01

Full Text Available The Work Package 1 “ Development and standardization of effective analytical tools for mycotoxin (aflatoxins B1, B2  G1, G2  ochratoxin A, zearalenone, fumonisin B1, B2  and tricothecenes determination in wheat and maize”  aim to implement the interlaboratory control between the partners laboratories from Brazil, Uruguay, Chile and Argentina as part of the objectives of INCO-DEV MYCOTOX PROJECT 2003-2005  “The Development of a Food Quality Management System for the Control of Mycotoxins in cereal Production and Processing Chains in Latin America South Cone Countries”.  The ojectives of the interlaboratory control were: evaluate the performance of the laboratories and the main difficulties encountered in performing the analytical procedure for mycotoxins  determination in maize and wheat; contribute to the harmonization of analytical procedures of the partners laboratories and contribute to the laboratory’s proficiency in mycotoxin analysis.  Maize reference materials for aflatoxins and zearealenone were prepared and used to the implementation of the interlaboratory control.  In summary, the preparation of these samples involved: milling (<20 mesh, homogeneization, analysis to verify the homogeneity of the bulk material and packing (labelled vacuum “sachets” or plastic bottles and mycotoxin analysis.  The homogeneity of the material was investigated by the analysis of variance – ANOVA- according to International Harmonized Protocol for the Proficiency testing of (ChemicalAnalytical Laboratories as established by ISO 43-1 – Annex at 95% of confidence level by calculating an F-statistic ans Ss/ÿ (ÿ =15%. All batches of test material were stored under – 18ºC and protected from light prior to and after packaging.  Aflatoxins in the test materials were determinated by immunoaffinity with liquid chromatography (LC with pos-column derivatization and thin layer chromatography (TLC.  Zearalenone in the test materials

Rapid Differentiation of Haemophilus influenzae and Haemophilus haemolyticus by Use of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry with ClinProTools Mass Spectrum Analysis.

Science.gov (United States)

Chen, Jonathan H K; Cheng, Vincent C C; Wong, Chun-Pong; Wong, Sally C Y; Yam, Wing-Cheong; Yuen, Kwok-Yung

2017-09-01

Haemophilus influenzae is associated with severe invasive disease, while Haemophilus haemolyticus is considered part of the commensal flora in the human respiratory tract. Although the addition of a custom mass spectrum library into the matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) system could improve identification of these two species, the establishment of such a custom database is technically complicated and requires a large amount of resources, which most clinical laboratories cannot afford. In this study, we developed a mass spectrum analysis model with 7 mass peak biomarkers for the identification of H. influenzae and H. haemolyticus using the ClinProTools software. We evaluated the diagnostic performance of this model using 408 H. influenzae and H. haemolyticus isolates from clinical respiratory specimens from 363 hospitalized patients and compared the identification results with those obtained with the Bruker IVD MALDI Biotyper. The IVD MALDI Biotyper identified only 86.9% of H. influenzae (311/358) and 98.0% of H. haemolyticus (49/50) clinical isolates to the species level. In comparison, the ClinProTools mass spectrum model could identify 100% of H. influenzae (358/358) and H. haemolyticus (50/50) clinical strains to the species level and significantly improved the species identification rate (McNemar's test, P mass spectrometry to handle closely related bacterial species when the proprietary spectrum library failed. This approach should be useful for the differentiation of other closely related bacterial species. Copyright © 2017 American Society for Microbiology.

ClinGen Pathogenicity Calculator: a configurable system for assessing pathogenicity of genetic variants.

Science.gov (United States)

Patel, Ronak Y; Shah, Neethu; Jackson, Andrew R; Ghosh, Rajarshi; Pawliczek, Piotr; Paithankar, Sameer; Baker, Aaron; Riehle, Kevin; Chen, Hailin; Milosavljevic, Sofia; Bizon, Chris; Rynearson, Shawn; Nelson, Tristan; Jarvik, Gail P; Rehm, Heidi L; Harrison, Steven M; Azzariti, Danielle; Powell, Bradford; Babb, Larry; Plon, Sharon E; Milosavljevic, Aleksandar

2017-01-12

The success of the clinical use of sequencing based tests (from single gene to genomes) depends on the accuracy and consistency of variant interpretation. Aiming to improve the interpretation process through practice guidelines, the American College of Medical Genetics and Genomics (ACMG) and the Association for Molecular Pathology (AMP) have published standards and guidelines for the interpretation of sequence variants. However, manual application of the guidelines is tedious and prone to human error. Web-based tools and software systems may not only address this problem but also document reasoning and supporting evidence, thus enabling transparency of evidence-based reasoning and resolution of discordant interpretations. In this report, we describe the design, implementation, and initial testing of the Clinical Genome Resource (ClinGen) Pathogenicity Calculator, a configurable system and web service for the assessment of pathogenicity of Mendelian germline sequence variants. The system allows users to enter the applicable ACMG/AMP-style evidence tags for a specific allele with links to supporting data for each tag and generate guideline-based pathogenicity assessment for the allele. Through automation and comprehensive documentation of evidence codes, the system facilitates more accurate application of the ACMG/AMP guidelines, improves standardization in variant classification, and facilitates collaborative resolution of discordances. The rules of reasoning are configurable with gene-specific or disease-specific guideline variations (e.g. cardiomyopathy-specific frequency thresholds and functional assays). The software is modular, equipped with robust application program interfaces (APIs), and available under a free open source license and as a cloud-hosted web service, thus facilitating both stand-alone use and integration with existing variant curation and interpretation systems. The Pathogenicity Calculator is accessible at http

A Mapping Method Applied to the IT Solutions Procurement Guide of IN/SLTI/ MPOG 04/2014 Normative Instruction and Models Constellation CMMI-ACQ, CMMI-DEV and CMMI-SVC

Directory of Open Access Journals (Sweden)

PLÁCIDO DA SILVA, L. S.

2016-12-01

Full Text Available Several initiatives have emerged in the search for improvement of software processes in recent years. These initiatives are usually guided by Standards, Models and Quality Standards, aiming to establish best practices to guide the definition of processes and support the assessment of the maturity and capacity of organizations in the development of software products and provision of IT services. Despite the emergence of several initiatives, when the topic refers to the processes of contracting information technology (IT solutions by the Brazilian Federal Public Administration (APF, its application in the context of organizations has obstacles, such as the complexity of the processes and oversight of federal government agencies. In order to overcome these obstacles, the Court of Audit of the Union (TCU recommended the preparation of the SLTI/MPOG 04/2014 Normative Instruction, containing guidelines for the process of contracting IT Solutions. This work defines a Mapping Method between IN/SLTI/MPOG 04/2014 and APF's IT Solutions Procurement Guide (GCSTI, with the objective of identifying the maturity and adherence of GCSTI to CMMI-ACQ, CMMI -DEV and CMMI-SVC. This work defines a Mapping Method between IN / SLTI / MPOG 04/2014 and its processes defined in the APF IT Solutions Procurement Guide (GCSTI, with the objective of identifying the maturity and adherence of the GCSTI to the Models CMMI-ACQ, CMMI-DEV and CMMI-SVC and bringing as benefits a systematized and structured methodology to apply and map models, norms and standards of any nature. As a result of this research, the mapping method created allowed the mapping between the CMMI and GSTI models of IN / SLTI / PMO 04/2014, and the method could be applied in any other mapping, from which the processes were oriented to the same Structure and had similar objectives.

Evidencia Empírica de la Minería de Procesos en la Implantación de CMMI-DEV

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Paola E. Velazquez-Solis

2016-11-01

Full Text Available La minería de procesos tiene como objetivo descubrir, monitorear y mejorar procesos a través del análisis de los diversos registros de eventos generados por los procesos de la organización. El objetivo de este trabajo es presentar la evidencia empírica de la inclusión estratégica de la disciplina de minería de procesos en proyectos de mejora de procesos de software implementados con CMMI. En el proceso de mapeo sistemático de la revisión de la literatura, se establecieron cuatro categorías para clasificar los hallazgos encontrados (Fundamentos teóricos, propuestas, herramientas y sistemas de información y algoritmos para presentar los estudios que cumplen con el objetivo. Se concluye que la interdisciplinariedad de la minería de procesos con un modelo de referencia de procesos como CMMI-DEV apoya la implementación y evaluación de las áreas de procesos, al aplicar técnicas y algoritmos de minería de procesos que faciliten la exploración y explotación de los registros de eventos relacionados a la ejecución de las actividades almacenados en un repositorio.

eddy4R 0.2.0: a DevOps model for community-extensible processing and analysis of eddy-covariance data based on R, Git, Docker, and HDF5

Science.gov (United States)

Metzger, Stefan; Durden, David; Sturtevant, Cove; Luo, Hongyan; Pingintha-Durden, Natchaya; Sachs, Torsten; Serafimovich, Andrei; Hartmann, Jörg; Li, Jiahong; Xu, Ke; Desai, Ankur R.

2017-08-01

Large differences in instrumentation, site setup, data format, and operating system stymie the adoption of a universal computational environment for processing and analyzing eddy-covariance (EC) data. This results in limited software applicability and extensibility in addition to often substantial inconsistencies in flux estimates. Addressing these concerns, this paper presents the systematic development of portable, reproducible, and extensible EC software achieved by adopting a development and systems operation (DevOps) approach. This software development model is used for the creation of the eddy4R family of EC code packages in the open-source R language for statistical computing. These packages are community developed, iterated via the Git distributed version control system, and wrapped into a portable and reproducible Docker filesystem that is independent of the underlying host operating system. The HDF5 hierarchical data format then provides a streamlined mechanism for highly compressed and fully self-documented data ingest and output. The usefulness of the DevOps approach was evaluated for three test applications. First, the resultant EC processing software was used to analyze standard flux tower data from the first EC instruments installed at a National Ecological Observatory (NEON) field site. Second, through an aircraft test application, we demonstrate the modular extensibility of eddy4R to analyze EC data from other platforms. Third, an intercomparison with commercial-grade software showed excellent agreement (R2 = 1.0 for CO2 flux). In conjunction with this study, a Docker image containing the first two eddy4R packages and an executable example workflow, as well as first NEON EC data products are released publicly. We conclude by describing the work remaining to arrive at the automated generation of science-grade EC fluxes and benefits to the science community at large. This software development model is applicable beyond EC and more generally builds

eddy4R 0.2.0: a DevOps model for community-extensible processing and analysis of eddy-covariance data based on R, Git, Docker, and HDF5

Directory of Open Access Journals (Sweden)

S. Metzger

2017-08-01

Full Text Available Large differences in instrumentation, site setup, data format, and operating system stymie the adoption of a universal computational environment for processing and analyzing eddy-covariance (EC data. This results in limited software applicability and extensibility in addition to often substantial inconsistencies in flux estimates. Addressing these concerns, this paper presents the systematic development of portable, reproducible, and extensible EC software achieved by adopting a development and systems operation (DevOps approach. This software development model is used for the creation of the eddy4R family of EC code packages in the open-source R language for statistical computing. These packages are community developed, iterated via the Git distributed version control system, and wrapped into a portable and reproducible Docker filesystem that is independent of the underlying host operating system. The HDF5 hierarchical data format then provides a streamlined mechanism for highly compressed and fully self-documented data ingest and output. The usefulness of the DevOps approach was evaluated for three test applications. First, the resultant EC processing software was used to analyze standard flux tower data from the first EC instruments installed at a National Ecological Observatory (NEON field site. Second, through an aircraft test application, we demonstrate the modular extensibility of eddy4R to analyze EC data from other platforms. Third, an intercomparison with commercial-grade software showed excellent agreement (R2  =  1.0 for CO2 flux. In conjunction with this study, a Docker image containing the first two eddy4R packages and an executable example workflow, as well as first NEON EC data products are released publicly. We conclude by describing the work remaining to arrive at the automated generation of science-grade EC fluxes and benefits to the science community at large. This software development model is applicable beyond EC

Sex. Dev.

OpenAIRE

Jakubiczka, S.; Schröder, C.; Ullmann, R.; Volleth, M.; Ledig, S.; Gilberg, E.; Kroisel, P.; P. Wieacker, P.

2010-01-01

Campomelic dysplasia (MIM 114290) is a severe malformation syndrome frequently accompanied by male-to-female sex reversal. Causative are mutations within the SOX9 gene on 17q24.3 as well as chromosomal aberrations (translocations, inversions or deletions) in the vicinity of SOX9 . Here, we report on a patient with muscular hypotonia, craniofacial dysmorphism, cleft palate, brachydactyly, malformations of thoracic spine, and gonadal dysgenesis with female external genitalia and müllerian duct ...

Déclin et restauration de la population de truites lacustres (Salmo trutta lacustris L. du lac de Constance

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RUHLÉ C.

1990-10-01

Full Text Available Le déclin de la population de truites migratrices du lac de Constance a débuté vers 1950 quand un barrage a été construit sur le Rhin, affluent principal de ce lac, coupant ainsi l'accès aux plus importantes frayères. Ceci a suffi de prétexte pour renoncer à une longueur de capture garantissant la reproduction naturelle. Par la suite, la population en train de diminuer a servi de justification pour des déversements importants de truites arc-en-ciel. Un désintérêt croissant pour le maintien de frayères dans les affluents secondaires a, finalement, contribué à la baisse des captures de 12.000 kg à 3.000 kg entre 1950 et 1980.Les mesures réalisées au cours des dernières années pour restaurer la population de truites lacustres ont du succès. Il s'agit surtout de : — la détermination d'une nouvelle longueur de capture ainsi que de périodes de protection respectant la reproduction des truites migrant à longue et à courte distance,— l'élevage de stocks de géniteurs, — les déversements forcés et effectués surtout en affluents (au lieu du lac,— l'interdiction d'immersions de truites arc-en-ciel,— l'abolition de barrages. Le succès se manifeste par un nombre croissant de truites observées frayant dans les affluents ainsi que par des captures de plus en plus nombreuses faites par la pêche professionnelle.

Opportunities and challenges for the integration of massively parallel genomic sequencing into clinical practice: lessons from the ClinSeq project.

Science.gov (United States)

Biesecker, Leslie G

2012-04-01

The debate surrounding the return of results from high-throughput genomic interrogation encompasses many important issues including ethics, law, economics, and social policy. As well, the debate is also informed by the molecular, genetic, and clinical foundations of the emerging field of clinical genomics, which is based on this new technology. This article outlines the main biomedical considerations of sequencing technologies and demonstrates some of the early clinical experiences with the technology to enable the debate to stay focused on real-world practicalities. These experiences are based on early data from the ClinSeq project, which is a project to pilot the use of massively parallel sequencing in a clinical research context with a major aim to develop modes of returning results to individual subjects. The study has enrolled >900 subjects and generated exome sequence data on 572 subjects. These data are beginning to be interpreted and returned to the subjects, which provides examples of the potential usefulness and pitfalls of clinical genomics. There are numerous genetic results that can be readily derived from a genome including rare, high-penetrance traits, and carrier states. However, much work needs to be done to develop the tools and resources for genomic interpretation. The main lesson learned is that a genome sequence may be better considered as a health-care resource, rather than a test, one that can be interpreted and used over the lifetime of the patient.

Ivan Grohar and Oskar Dev – An Interdisciplinary and Multidisciplinary Fragment Comparison of Their Artistic Works in Škofja Loka/Slovenia (1905-1911

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Franc Križnar

2014-12-01

Full Text Available The new Grohar’s room in the Škofja Loka Mu¬seum that is located in a more than a thousand years old town, some kilometres northwest of Ljubljana, Slove¬nia, represents one of the new possibilities to popularize old local history. Ivan Grohar (1867−1911 is one of the four well-known Slovenian painters from the beginning of the 20th century, together with Rihard Jakopič, Matija Jama and Matej Sternen. These Slovenian painters are the founders of Impressionism within the modern style. Škofja Loka became the so called Slovenian “Barbizon” (i.e. French village near Fontainebleau, once the settle-ment of painters and this art and old tradition inspired another Slovenian (music artist Oskar Dev (1868−1932, who composed some of his musical works (songs and choirs in Škofja Loka, too. His and Grohar’s period in Škofja Loka resulted in some extraordinary art works i.e. paintings and musical works. They both were inspired by the countryside that reflected on their works. This is now one of the new Slovenian’s challenges of museology and musicology in an interdisciplinary and multidisciplinary approach so the art of painting and music could be a benefit for the visitors of this and other museums.

Construction of a full-length infectious bacterial artificial chromosome clone of duck enteritis virus vaccine strain

Science.gov (United States)

2013-01-01

Background Duck enteritis virus (DEV) is the causative agent of duck viral enteritis, which causes an acute, contagious and lethal disease of many species of waterfowl within the order Anseriformes. In recent years, two laboratories have reported on the successful construction of DEV infectious clones in viral vectors to express exogenous genes. The clones obtained were either created with deletion of viral genes and based on highly virulent strains or were constructed using a traditional overlapping fosmid DNA system. Here, we report the construction of a full-length infectious clone of DEV vaccine strain that was cloned into a bacterial artificial chromosome (BAC). Methods A mini-F vector as a BAC that allows the maintenance of large circular DNA in E. coli was introduced into the intergenic region between UL15B and UL18 of a DEV vaccine strain by homologous recombination in chicken embryoblasts (CEFs). Then, the full-length DEV clone pDEV-vac was obtained by electroporating circular viral replication intermediates containing the mini-F sequence into E. coli DH10B and identified by enzyme digestion and sequencing. The infectivity of the pDEV-vac was validated by DEV reconstitution from CEFs transfected with pDEV-vac. The reconstructed virus without mini-F vector sequence was also rescued by co-transfecting the Cre recombinase expression plasmid pCAGGS-NLS/Cre and pDEV-vac into CEF cultures. Finally, the in vitro growth properties and immunoprotection capacity in ducks of the reconstructed viruses were also determined and compared with the parental virus. Results The full genome of the DEV vaccine strain was successfully cloned into the BAC, and this BAC clone was infectious. The in vitro growth properties of these reconstructions were very similar to parental DEV, and ducks immunized with these viruses acquired protection against virulent DEV challenge. Conclusions DEV vaccine virus was cloned as an infectious bacterial artificial chromosome maintaining full

Point-of-Care Healthcare Databases Are an Overall Asset to Clinicians, but Different Databases May Vary in Usefulness Based on Personal Preferences. A Review of: Chan, R. & Stieda, V. (2011. Evaluation of three point-of-care healthcare databases: BMJ Point-of-Care, Clin-eguide and Nursing Reference Centre. Health and Information Libraries Journal, 28(1, 50-58. doi: 10.1111/j.1471-1842.2010.00920.x

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Carol D. Howe

2011-01-01

Full Text Available Objective – To evaluate the usefulness of three point-of-care healthcare databases (BMJ Point-of-Care, Clin-eguide, and Nursing Reference Centre in clinical practice.Design – A descriptive study analyzing questionnaire results.Setting – Hospitals within Alberta, Canada’s two largest health regions (at the time of this study, with a third health region submitting a small number of responses.Subjects – A total of 46 Alberta hospital personnel answered the questionnaire, including 19 clinicians, 7 administrators, 6 nurses, 1 librarian, 1 preceptor, and “some” project coordinators. Subjects were chosen using a non-probability sampling method.Methods – The researchers developed an online questionnaire consisting of 17 questions and posted it on the University of Calgary’s Health Sciences Library and the Health Knowledge Network websites. The questions, in general, asked respondents how easy the databases were to search and use, whether the database content answered their clinical questions, and whether they would recommend the databases for future purchase. Most questions required a response for each of the three databases. The researchers collected quantitative data by using a Likert scale from 1 to 5, with 5 being the most positive answer and 1 being the most negative. They collected qualitative data by asking open-ended questions.Main Results – With regard to ease of searching, BMJ Point-of-Care (BMJ received the greatest number of responses (71% at level 5. A smaller number of respondents (56% rated Nursing Reference Centre (NRC at level 5. Clin-eguide received 59% of the responses at level 5, but it also received the greatest number of responses at the next highest level (level 4. Respondents rated all three databases similarly with regard to levels 1 and 2.Regarding how easy the resources were to learn, most respondents rated all three databases as easy to learn (BMJ, 77%; Clin-eguide, 72%; and NRC, 68%. Very few respondents

A Mapping Study on Cooperation between Information System Development and Operations

NARCIS (Netherlands)

Erich, Floris; Amrit, Chintan Amrit; Daneva, Maia; Jedlitschka, Andreas; Kuvaja, Pasi; Kuhrmann, Marco; Männistö, Tomi; Münch, Jürgen; Raatikainen, Mikko

2014-01-01

DevOps is a conceptual framework for reintegrating development and operations of Information Systems.We performed a Systematic Mapping Study to explore DevOps. 26 articles out of 139 were selected, studied and summarized. Based on this a concept table was constructed. We discovered that DevOps has

Expression and characterization of UL16 gene from duck enteritis virus

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Wang Mingshu

2011-08-01

Full Text Available Abstract Background Previous studies have indicated that the UL16 protein and its homologs from herpesvirus were conserved and played similar roles in viral DNA packaging, virion assembly, budding, and egress. However, there was no report on the UL16 gene product of duck enteritis virus (DEV. In this study, we analyzed the amino acid sequence of UL16 using bioinformatics tools and expressed in Escherichia coli Rosetta (DE3 induced by isopropy1-β-D-thiogalactopyranoside (IPTG. The recombinant protein was produced, purified using a Ni-NTA column and used to generate the polyclonal antibody against UL16. The intracellular distribution of the DEV UL16 product was carried out using indirect immunofluorescence assay. Results In our study, UL16 gene of DEV was composed of 1089 nucleotides, which encoded 362 amino acids. Multiple sequence alignment suggested that the UL16 gene was highly conserved in herpesvirus family. The UL16 gene was cloned into a pET prokaryotic expression vector and transformed into Escherichia coli Rossetta (DE3 induced by IPTG. A 60kDa fusion protein band corresponding to the predicted size was produced on the SDS-PAGE, purified using a Ni-NTA column. Anti-UL16 polyclonal sera was prepared by immunizing rabbits, and reacted with a band in the IPTG induced cell lysates with an apparent molecular mass of 60 kDa. In vivo expression of the UL16 protein in DEV infected duck embryo fibroblast cells (DEFs was localized mostly around perinuclear cytoplasmic area and in cytosol using indirect immunofluorescence assay. Conclusions The UL16 gene of DEV was successfully cloned, expressed and detected in DEV infected DEFs for the first time. The UL16 protein localized mostly around perinuclear cytoplasmic area and in cytosol in DEV infected DEFs. DEV UL16 shared high similarity with UL16 family members, indicating that DEV UL16 many has similar function with its homologs. All these results may provide some insight for further research about

Development and evaluation of an immunochromatographic strip test based on the recombinant UL51 protein for detecting antibody against duck enteritis virus

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Sun Tao

2010-10-01

Full Text Available Abstract Background Duck enteritis virus (DEV infection causes substantial economic losses to the worldwide duck-producing areas. The monitoring of DEV-specific antibodies is a key to evaluate the effect of DEV vaccine and develop rational immunization programs. Thus, in this study, an immunochromatographic strip (ICS test was developed for detecting DEV serum antibodies. Results The ICS test is based on membrane chromatography, and uses both the purified recombinant UL51 protein conjugated with colloidal gold and goat anti-rabbit IgG conjugated with colloidal gold as tracers, the purified recombinant UL51 protein as the capture reagent at the test line, and rabbit IgG as the capture reagent at the control line. The specificity of the ICS was evaluated by sera against DEV, Duck hepatitis virus (DHV, Riemerella anatipestifer (RA, Duck E. coli, Muscovy duck parvovirus (MPV, or Duck Influenza viruses (DIV. Only sera against DEV showed the strong positive results. In order to determine the sensitivity of the ICS, anti-DEV serum diluted serially was tested, and the minimum detection limit of 1:128 was obtained. The ICS components, which are provided in a sealed package, require no refrigeration and are stable for 12 months. To evaluate the effect of the ICS, 110 duck serum samples collected from several non-immune duck flocks were simultaneously tested by the ICS test, enzyme-linked immunosorbent assay (ELISA and neutralization test (NT. The results showed that the sensitivity of the ICS test was almost consistent with ELISA and much higher than NT, has low cost, and is rapid (15 min and easy to perform with no requirement of specialized equipment, reagent or technicians. Conclusions In this work, we successfully developed a simple and rapid ICS test for detecting DEV serum antibodies for the first time. The ICS test was high specific and sensitive for the rapid detection of anti-DEV antibodies, and has great potential to be used for the serological

Relancer Saint-Étienne. Conditions institutionnelles et capacité d’action collective dans une ville en déclin

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Vincent Béal

2010-11-01

Full Text Available L'objectif de cet article est de comprendre comment une capacité d’action collective peut se construire dans une ville marquée par une industrialisation ancienne et, plus récemment, par un déclin démographique et économique. La thèse principale de l'article, inspirée par l’économie politique et le néo-institutionnalisme, est que la difficulté d’un territoire d’ancienne industrialisation à constituer une capacité d’action collective peut certes s’expliquer par une position défavorable dans la nouvelle division internationale du travail mais aussi par les conditions institutionnelles engendrées par ce passé industriel et la crise économique et démographique. Dans le cas de Saint-Étienne analysé dans cet article, les modalités historiques de l’industrialisation mais aussi les modalités de gestion de la crise de désindustrialisation ont engendré des conditions institutionnelles –dispositions à la prise de parole età la coopération, nature des rapports entre les différents types d’organisation (milieux économiques, classe politique locale, État- peu favorables à l’émergence d’une capacité d’action collective et à l’élaboration de stratégies partagées de sortie de crise.The objective of the article is to understand how a political capacity can emerge in a city characterised by an ancient process of industrialisation and, more recently, by an economic and demographic decline. The central thesis of the article is inspired by political economy and neo-institutionalism. One considers that the difficulties faced by a place of old industry to build up a political capacity can admittedly be explained by an unfavourable position in the international division of labour but also the institutional conditions generated by the industrial past and the economic and demographic crisis. In the case of the French city of Saint-Étienne, analysed in this article, the historical modalities in which

Genomic regulatory landscapes and chromosomal rearrangements

DEFF Research Database (Denmark)

Ladegaard, Elisabete L Engenheiro

2008-01-01

The main objectives of the PhD study are to identify and characterise chromosomal rearrangements within evolutionarily conserved regulatory landscapes around genes involved in the regulation of transcription and/or development (trans-dev genes). A frequent feature of trans-dev genes is that they ......The main objectives of the PhD study are to identify and characterise chromosomal rearrangements within evolutionarily conserved regulatory landscapes around genes involved in the regulation of transcription and/or development (trans-dev genes). A frequent feature of trans-dev genes...... the complex spatio-temporal expression of the associated trans-dev gene. Rare chromosomal breakpoints that disrupt the integrity of these regulatory landscapes may be used as a tool, not only to make genotype-phenotype associations, but also to link the associated phenotype with the position and tissue...... specificity of the individual CNEs. In this PhD study I have studied several chromosomal rearrangements with breakpoints in the vicinity of trans-dev genes. This included chromosomal rearrangements compatible with known phenotype-genotype associations (Rieger syndrome-PITX2, Mowat-Wilson syndrome-ZEB2...

In silico discovery of the dormancy regulons in a number of Actinobacteria genomes

Energy Technology Data Exchange (ETDEWEB)

Gerasimova, Anna; Dubchak, Inna; Arkin, Adam; Gelfand, Mikhail

2010-11-16

Mycobacterium tuberculosis is a dangerous Actinobacteria infecting nearly one third of the human population. It becomes dormant and phenotypically drug resistant in response to stresses. An important feature of the M. tuberculosis pathogenesis is the prevalence of latent infection without disease, making understanding of the mechanisms used by the bacteria to exist in this state and to switch to metabolically active infectious form a vital problem to consider. M. tuberculosis dormancy is regulated by the three-component regulatory system of two kinases (DosT and DevS) and transcriprional regulator (DevR). DevR activates transcription of a set of genes, which allow the bacteria to survive long periods of anaerobiosis, and may be important for long-term survival within the host during latent infection. The DevR-regulon is studied experimentally in M. tuberculosis and few other phylogenetically close Mycobacteria spp. As many other two-component systems, the devRS operon is autoregulated. However, the mechanism of the dormancy is not completely clear even for these bacteria and there is no data describing the dormancy regulons in other species.

A "Research" into International Student-Related Research: (Re)visualising Our Stand?

Science.gov (United States)

Abdullah, Doria; Abd Aziz, Mohd Ismail; Mohd Ibrahim, Abdul Latiff

2014-01-01

This paper uses Tight ("High Educ Res Dev" 23(4):395-411, 2004; "High Educ Res Dev" 31(5):723-740, 2012; "High Educ Res Dev" 32(1):136-151, 2013)'s journal analysis and review framework to review a sample of 497 journal articles on researches concerning international students over the past 30 years. It was found…

Identification of a novel linear B-cell epitope in the UL26 and UL26.5 proteins of Duck Enteritis Virus

Directory of Open Access Journals (Sweden)

Kong Xiangang

2010-09-01

Full Text Available Abstract Background The Unique Long 26 (UL26 and UL26.5 proteins of herpes simplex virus are known to function during the assembly of the viruses. However, for duck enteritis virus (DEV, which is an unassigned member of the family Herpesviridae, little information is available about the function of the two proteins. In this study, the C-terminus of DEV UL26 protein (designated UL26c, which contains the whole of UL26.5, was expressed, and the recombinant UL26c protein was used to immunize BALB/c mice to generate monoclonal antibodies (mAb. The mAb 1C8 was generated against DEV UL26 and UL26.5 proteins and used subsequently to map the epitope in this region. Both the mAb and its defined epitope will provide potential tools for further study of DEV. Results A mAb (designated 1C8 was generated against the DEV UL26c protein, and a series of 17 partially overlapping fragments that spanned the DEV UL26c were expressed with GST tags. These peptides were subjected to enzyme-linked immunosorbent assay (ELISA and western blotting analysis using mAb 1C8 to identify the epitope. A linear motif, 520IYYPGE525, which was located at the C-terminus of the DEV UL26 and UL26.5 proteins, was identified by mAb 1C8. The result of the ELISA showed that this epitope could be recognized by DEV-positive serum from mice. The 520IYYPGE525 motif was the minimal requirement for reactivity, as demonstrated by analysis of the reactivity of 1C8 with several truncated peptides derived from the motif. Alignment and comparison of the 1C8-defined epitope sequence with those of other alphaherpesviruses indicated that the motif 521YYPGE525 in the epitope sequence was conserved among the alphaherpesviruses. Conclusion A mAb, 1C8, was generated against DEV UL26c and the epitope-defined minimal sequence obtained using mAb 1C8 was 520IYYPGE525. The mAb and the identified epitope may be useful for further study of the design of diagnostic reagents for DEV.

Association between Antioxidant Enzyme Activities and Enterovirus-Infected Type 1 Diabetic Children.

Science.gov (United States)

Abdel-Moneim, Adel; El-Senousy, Waled M; Abdel-Latif, Mahmoud; Khalil, Rehab G

2018-01-01

To examine the effect of infection with Enterovirus (EV) in children with type 1 diabetes (T1D) on the activities of serum antioxidant enzymes in diabetic and nondiabetic controls. Three hundred and eighty-two diabetic and 100 nondiabetic children were tested for EV RNA using reverse transcriptase (RT)-PCR. The activities of serum superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were also estimated in diabetic patients infected with EV (T1D-EV+), those not infected with EV (T1D-EV-), and in nondiabetic controls. The frequency of EV was higher in diabetic children (100/382; 26.2%) than in healthy controls (0/100). Levels of fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c) and C-reactive protein (CRP) were significantly higher but C-peptide was significantly lower in diabetic children than in controls. CRP levels were higher in the T1D-EV+ group than in the T1D-EV- group, and higher in all diabetic children than in nondiabetic controls. The activities of the antioxidant enzymes GPx, SOD, and CAT decreased significantly in diabetic children compared to in controls. Moreover, the activities of the enzymes tested were significantly reduced in the T1D-EV+ group compared to in the T1D-EV- group. Our data indicate that EV infection correlated with a decrease in the activity of antioxidant enzymes in the T1D-EV+ group compared to in the T1D-EV- group; this may contribute to β cell damage and increased inflammation. © 2018 The Author(s) Published by S. Karger AG, Basel.

On constructing optimistic simulation algorithms for the discrete event system specification

International Nuclear Information System (INIS)

Nutaro, James J.

2008-01-01

This article describes a Time Warp simulation algorithm for discrete event models that are described in terms of the Discrete Event System Specification (DEVS). The article shows how the total state transition and total output function of a DEVS atomic model can be transformed into an event processing procedure for a logical process. A specific Time Warp algorithm is constructed around this logical process, and it is shown that the algorithm correctly simulates a DEVS coupled model that consists entirely of interacting atomic models. The simulation algorithm is presented abstractly; it is intended to provide a basis for implementing efficient and scalable parallel algorithms that correctly simulate DEVS models

ClinGen--the Clinical Genome Resource.

Science.gov (United States)

Rehm, Heidi L; Berg, Jonathan S; Brooks, Lisa D; Bustamante, Carlos D; Evans, James P; Landrum, Melissa J; Ledbetter, David H; Maglott, Donna R; Martin, Christa Lese; Nussbaum, Robert L; Plon, Sharon E; Ramos, Erin M; Sherry, Stephen T; Watson, Michael S

2015-06-04

On autopsy, a patient is found to have hypertrophic cardiomyopathy. The patient’s family pursues genetic testing that shows a “likely pathogenic” variant for the condition on the basis of a study in an original research publication. Given the dominant inheritance of the condition and the risk of sudden cardiac death, other family members are tested for the genetic variant to determine their risk. Several family members test negative and are told that they are not at risk for hypertrophic cardiomyopathy and sudden cardiac death, and those who test positive are told that they need to be regularly monitored for cardiomyopathy on echocardiography. Five years later, during a routine clinic visit of one of the genotype-positive family members, the cardiologist queries a database for current knowledge on the genetic variant and discovers that the variant is now interpreted as “likely benign” by another laboratory that uses more recently derived population-frequency data. A newly available testing panel for additional genes that are implicated in hypertrophic cardiomyopathy is initiated on an affected family member, and a different variant is found that is determined to be pathogenic. Family members are retested, and one member who previously tested negative is now found to be positive for this new variant. An immediate clinical workup detects evidence of cardiomyopathy, and an intracardiac defibrillator is implanted to reduce the risk of sudden cardiac death.

Point-of-Care Healthcare Databases Are an Overall Asset to Clinicians, but Different Databases May Vary in Usefulness Based on Personal Preferences. A Review of: Chan, R. & Stieda, V. (2011). Evaluation of three point-of-care healthcare databases: BMJ Point-of-Care, Clin-eguide and Nursing Reference Centre. Health and Information Libraries Journal, 28(1), 50-58. doi: 10.1111/j.1471-1842.2010.00920.x

OpenAIRE

Carol D. Howe

2011-01-01

Objective – To evaluate the usefulness of three point-of-care healthcare databases (BMJ Point-of-Care, Clin-eguide, and Nursing Reference Centre) in clinical practice.Design – A descriptive study analyzing questionnaire results.Setting – Hospitals within Alberta, Canada’s two largest health regions (at the time of this study), with a third health region submitting a small number of responses.Subjects – A total of 46 Alberta hospital personnel answered the questionnaire, including 19 clinician...

Fıtrat Hadisi’nin Osmanlı'nın Devşirme Sisteminde Hayata Aksedişi 'The Hadith of Fitrah’ And How It Is Reflected On Life Ottoman’s Devshirme System

Directory of Open Access Journals (Sweden)

Mustafa IŞIK

2013-07-01

-culture on thisevent with together ‘Devshirme’. ‘Her çocuk, fıtrat üzere doğar; sonra onu ana-babası Yahudileştirir, Hıristiyanlaştırır veya Mecusîleştirir’ hadisi, temel İslam bilimlerinde ‘fıtrat hadisi’ olarak bilinir. İslami literatürde, geçmişten günümüze, bu hadis hakkında çeşitli görüşler ortaya konmuştur. Fıtrat hadisinin, klasik hadis literatüründeki kaynakları ve hadis imamlarının bu hadise bakışları açısından daha çok ‘Çocuğun ölmesi halinde dinî ve hukukî durumunun ne olacağı?’ sorusu üzerinde durulmuştur. Ancak hadis bilginleri ve bazı interdisipliner İslam âlimleri, fıtrat’ın ‘insanlığın ortak dinî temeli’ olduğuna inanmaktadırlar. Bu görüşe bağlı olarak biz, fıtrat hadisi’nin Osmanlı’daki ‘devşirme’ hadisesiyle örtüştüğünü düşünüyoruz. Devşirme sisteminin, tarihi bir olgu olarak, Osmanlı’da gerçekleşen halini ele almak istiyoruz. Bu haliyle Osmanlı Devleti bu olguyu sistemleştirip kanun, tüzük ve yönetmeliği olan bir sistem haline koymadan önce dini yönünü hesaba kattığını; bu hadisteki ‘fıtrat gerçeği’nden hareket etmiş olabileceğini; güçlü kaslar ve çalışkan beyinler sayesinde özelde devletine genelde insanlığa hizmet ettiğini var sayıyoruz. O günün dünya devleti olan Osmanlı’dan bugünün dünya devleti ABD’ye baktığımızda, işleyiş ve yöntem farklı olsa da, birtakım paralellikler görmekteyiz. Farklı asırlarda, değişik coğrafyalarda, birbirine benzemeyen iki büyük medeniyetin ortaya koyduğu uygulamadaki benzerlik ve ulaştığı ortak nokta, eğitimin, başat belirleyici olduğu gerçeğidir. Bu makalenin amacı, sadece tarihî bir fenomeni dile getirmek değil; fıtratın anlamını, geçerliliğini bu tarihî olgudan hareketle yinelemektir. Makalemizde bu konuyu fıtrat yani insanın değişmeyen varlık yapısı ve eğitim-kültürün bu yapıya etkisini ‘devşirme’ olgusuyla

Estimation of wave forces on a tethered spherical float using potential flow theory

Digital Repository Service at National Institute of Oceanography (India)

Vethamony, P.; Chandramohan, P.; Sastry, J.S.

stream_size 9 stream_content_type text/plain stream_name Proc_Int_Conf_Coast_Port_Eng_Dev_Countries_1991_1442.pdf.txt stream_source_info Proc_Int_Conf_Coast_Port_Eng_Dev_Countries_1991_1442.pdf.txt Content-Encoding ISO-8859...

Strategy for increasing marine fish production in Goa

Digital Repository Service at National Institute of Oceanography (India)

Parulekar, A

stream_size 5 stream_content_type text/plain stream_name Proc_Workshop_Evol_Strat_Dev_Agric_Anim_Husb_Fish_Goa_1991_73.pdf.txt stream_source_info Proc_Workshop_Evol_Strat_Dev_Agric_Anim_Husb_Fish_Goa_1991_73.pdf.txt Content...

ClinGen — The Clinical Genome Resource

Science.gov (United States)

Rehm, Heidi L.; Berg, Jonathan S.; Brooks, Lisa D.; Bustamante, Carlos D.; Evans, James P.; Landrum, Melissa J.; Ledbetter, David H.; Maglott, Donna R.; Martin, Christa Lese; Nussbaum, Robert L.; Plon, Sharon E.; Ramos, Erin M.; Sherry, Stephen T.; Watson, Michael S.

2015-01-01

On autopsy, a patient is found to have hypertrophic cardiomyopathy. The patient’s family pursues genetic testing that shows a “likely pathogenic” variant for the condition on the basis of a study in an original research publication. Given the dominant inheritance of the condition and the risk of sudden cardiac death, other family members are tested for the genetic variant to determine their risk. Several family members test negative and are told that they are not at risk for hypertrophic cardiomyopathy and sudden cardiac death, and those who test positive are told that they need to be regularly monitored for cardiomyopathy on echocardiography. Five years later, during a routine clinic visit of one of the genotype-positive family members, the cardiologist queries a database for current knowledge on the genetic variant and discovers that the variant is now interpreted as “likely benign” by another laboratory that uses more recently derived population-frequency data. A newly available testing panel for additional genes that are implicated in hypertrophic cardiomyopathy is initiated on an affected family member, and a different variant is found that is determined to be pathogenic. Family members are retested, and one member who previously tested negative is now found to be positive for this new variant. An immediate clinical workup detects evidence of cardiomyopathy, and an intracardiac defibrillator is implanted to reduce the risk of sudden cardiac death. PMID:26014595

Closing the IT Development-operations Gap

DEFF Research Database (Denmark)

Arentoft Nielsen, Pia; Winkler, Till J.; Nørbjerg, Jacob

2017-01-01

Although DevOps has been heralded as a novel paradigm to overcome the traditional boundaries between IT Development (Dev) and IT Operations (Ops) teams, many IT organizations lack guidance on how to implement this paradigm in practice. This design research provides a framework that can aid...

Resonance Energy Transfer-Based Molecular Switch Designed Using a Systematic Design Process Based on Monte Carlo Methods and Markov Chains

Science.gov (United States)

Rallapalli, Arjun

A RET network consists of a network of photo-active molecules called chromophores that can participate in inter-molecular energy transfer called resonance energy transfer (RET). RET networks are used in a variety of applications including cryptographic devices, storage systems, light harvesting complexes, biological sensors, and molecular rulers. In this dissertation, we focus on creating a RET device called closed-diffusive exciton valve (C-DEV) in which the input to output transfer function is controlled by an external energy source, similar to a semiconductor transistor like the MOSFET. Due to their biocompatibility, molecular devices like the C-DEVs can be used to introduce computing power in biological, organic, and aqueous environments such as living cells. Furthermore, the underlying physics in RET devices are stochastic in nature, making them suitable for stochastic computing in which true random distribution generation is critical. In order to determine a valid configuration of chromophores for the C-DEV, we developed a systematic process based on user-guided design space pruning techniques and built-in simulation tools. We show that our C-DEV is 15x better than C-DEVs designed using ad hoc methods that rely on limited data from prior experiments. We also show ways in which the C-DEV can be improved further and how different varieties of C-DEVs can be combined to form more complex logic circuits. Moreover, the systematic design process can be used to search for valid chromophore network configurations for a variety of RET applications. We also describe a feasibility study for a technique used to control the orientation of chromophores attached to DNA. Being able to control the orientation can expand the design space for RET networks because it provides another parameter to tune their collective behavior. While results showed limited control over orientation, the analysis required the development of a mathematical model that can be used to determine the

Fundamental Particle Combustion Kinetics Measurement in the Shock Tube in Support of Enhanced Blast Weapons Development

Science.gov (United States)

2012-07-01

deviation (STD dev) for initial peak AIO intensity signal for 20C and 20A tests in air llnitial Peak AIO Intensity 20C in air [average 1659 ~ td . dev...132 20A in air [average 2660 ~ td . dev. 295 The 50% 3 J.lm tests in air and 02 show repeatability, as shown in Figure VI.7 and Figure VI.8. In air...0629 20A 20%3 Jlffi 0.738 1.111 K>.699 0.471 0.555 0.636 0629 20C 20%40 )...LID 0.681 1.0~ ~ .700 0.606 0.731 0.618 0626 50 50%3 )...LID 0.714 1. llj

Expression and characterization of the UL31 protein from duck enteritis virus

Directory of Open Access Journals (Sweden)

Zhu Dekang

2009-02-01

Full Text Available Abstract Background Previous studies indicate that the UL31 protein and its homology play similar roles in nuclear egress of all herpesviruses. However, there is no report on the UL31 gene product of DEV. In this study, we expressed and presented the basic properties of the DEV UL31 product. Results The entire ORF of the UL31 was cloned into pET 32a (+ prokaryotic expression vector. Escherichia coli BL21(DE3 competent cells were transformed with the construct followed by the induction of protein expression by the addition of IPTG. Band corresponding to the predicted sizes (55 kDa was produced on the SDS-PAGE. Over expressed 6×His-UL31 fusion protein was purified by nickel affinity chromatography. The DEV UL31 gene product has been identified by using a rabbit polyclonal antiserum raised against the purified protein. A protein of approximate 35 kDa that reacted with the antiserum was detected in immunoblots of DEV-infected cellular lysates, suggesting that the 35 kDa protein was the primary translation product of the UL31 gene. RT-PCR analyses revealed that the UL31 gene was transcribed most abundantly during the late phase of replication. Subsequently, Immunofluorescence analysis revealed that the protein was widespread speckled structures in the nuclei of infected cells. Western blotting of purified virion preparations showed that UL31 was a component of intracellular virions but was absent from mature extracellular virions. Finally, an Immunofluorescence assay was established to study the distribution of the UL31 antigen in tissues of artificially DEV infected ducks. The results showed that the UL31 antigen was primarily located in the cells of digestive organs and immunological organs. Conclusion In this work, we present the basic properties of the DEV UL31 product. The results indicate that DEV UL31 shares many similarities with its HSV or PRV homolog UL31 and suggest that functional cross-complementation is possible between members of the

Central Asia | Page 15 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Language French. Read more about Adaptation aux changements climatiques et sécurité alimentaire et hydrique au Pakistan. Language French. Read more about Soutien à SciDev.Net. Language French. Read more about Support to SciDev.Net. Language English. Read more about Peer-to-Peer Mentoring of Science ...

Major hindrance to the dev't

African Journals Online (AJOL)

User

of opportunities for students to engage in activities that maximize the use of English outside the ... counsel them to increase confidence and commitment to take charge of their own learning ... level of motivation in learning it, and be able to ...

Forcecom Developer Certification Handbook (DEV401)

CERN Document Server

Kabe, Siddhesh

2012-01-01

A practical guide that will help you discover fundamentals for building applications on Force.com without writing a single line of code. If you are new to the Force.com platform and want to learn from scratch, it is advisable that you begin with the first chapter and move on to the last. However, if you are familiar with Force.com and want to understand in detail some aspect of it, you can dip into any chapter. Each certification module is covered in a separate chapter, and is accompanied by questions being asked in the exams. Developers who need to prepare for the Salesforce.com Certified For

ComDev in the Mediatized World

DEFF Research Database (Denmark)

Tufte, Thomas; Hemer, Oscar

2012-01-01

revolution are rightfully refuted, the on-going Arab Spring is a clear-cut example of an unprecedented communication power, largely out of the authorities’ control. While the crucial role of media and communication in processes of social change at last becomes evident, it is however not associated...

Brief Report: Insistence on Sameness, Anxiety, and Social Motivation in Children with Autism Spectrum Disorder

Science.gov (United States)

Factor, Reina S.; Condy, Emma E.; Farley, Julee P.; Scarpa, Angela

2016-01-01

While the function of restricted repetitive behaviors (RRBs) in autism spectrum disorder (ASD) is unclear, RRBs may function as anxiety reduction strategies (Joosten et al. "J Autism Dev Disord" 39(3):521-531, 2009. Moreover, anxiety in ASD is associated with low social motivation (Swain et al. "J Autism Dev Disord," 2015. The…

The Tomb of Ptahemwia, 'Great Overseer of Cattle' and 'Overseer of the Treasury of the Ramesseum', at Saqqara

NARCIS (Netherlands)

Staring, N.T.B.

2016-01-01

In early 1859, the French Egyptologist Théodule Devéria was in Egypt to assist Auguste Mariette—who had just been appointed as Director of Antiquities—with copying texts at a number of sites in Egypt. At Saqqara, Devéria photographed a doorway of the now-lost tomb of Ptahemwia, the early Nineteenth

DMPD: CSF-1 and cell cycle control in macrophages. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 8981359 CSF-1 and cell cycle control in macrophages. Hamilton JA. Mol Reprod Dev. 1...997 Jan;46(1):19-23. (.png) (.svg) (.html) (.csml) Show CSF-1 and cell cycle control in macrophages. PubmedI...D 8981359 Title CSF-1 and cell cycle control in macrophages. Authors Hamilton JA. Publication Mol Reprod Dev

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. B N Dev. Articles written in Bulletin of Materials Science. Volume 29 Issue 2 April 2006 pp 101-105 Polymers. Proton microbeam irradiation effects on PtBA polymer · J Kamila S Roy K Bhattacharjee B Rout B N Dev R Guico J Wang A W Haberl P Ayyub P V Satyam.

Duck enteritis virus glycoprotein D and B DNA vaccines induce immune responses and immunoprotection in Pekin ducks.

Science.gov (United States)

Zhao, Yan; Cao, Yongsheng; Cui, Lihong; Ma, Bo; Mu, Xiaoyu; Li, Yanwei; Zhang, Zhihui; Li, Dan; Wei, Wei; Gao, Mingchun; Wang, Junwei

2014-01-01

DNA vaccine is a promising strategy for protection against virus infection. However, little is known on the efficacy of vaccination with two plasmids for expressing the glycoprotein D (gD) and glycoprotein B (gB) of duck enteritis virus (DEV) in inducing immune response and immunoprotection against virulent virus infection in Pekin ducks. In this study, two eukaryotic expressing plasmids of pcDNA3.1-gB and pcDNA3.1-gD were constructed. Following transfection, the gB and gD expressions in DF1 cells were detected. Groups of ducks were vaccinated with pcDNA3.1-gB and/or pcDNA3.1-gD, and boosted with the same vaccine on day 14 post primary vaccination. We found that intramuscular vaccinations with pcDNA3.1-gB and/or pcDNA3.1-gD, but not control plasmid, stimulated a high frequency of CD4+ and CD8+ T cells in Pekin ducks, particularly with both plasmids. Similarly, vaccination with these plasmids, particularly with both plasmids, promoted higher levels of neutralization antibodies against DEV in Pekin ducks. More importantly, vaccination with both plasmids significantly reduced the virulent DEV-induced mortality in Pekin ducks. Our data indicated that vaccination with plasmids for expressing both gB and gD induced potent cellular and humoral immunity against DEV in Pekin ducks. Therefore, this vaccination strategy may be used for the prevention of DEV infection in Pekin ducks.

Investigating the role of feedback and motivation in clinical reaction time assessment.

Science.gov (United States)

Eckner, James T; Chandran, Srikrishna; Richardson, James K

2011-12-01

To investigate the influence of performance feedback and motivation during 2 tests of simple visuomotor reaction time (RT). Cross-sectional, observational study. Outpatient academic physiatry clinic. Thirty-one healthy adults (mean [SD], 54 ± 15 years). Participants completed a clinical test of RT (RT(clin)) and a computerized test of RT with and without performance feedback (RT(compFB) and RT(compNoFB), respectively) in randomly assigned order. They then ranked their degree of motivation during each test. RT(clin) measured the time required to catch a suspended vertical shaft by hand closure after release of the shaft by the examiner. RT(compFB) and RT(compNoFB) both measured the time required to press a computer key in response to a visual cue displayed on a computer monitor. Performance feedback (visual display of the previous trial and summary results) was provided for RT(compFB), but not for RT(compNoFB). Means and standard deviations of RT(clin), RT(compFB), and RT(compNoFB) and participants' self-reported motivation on a 5-point Likert scale for each test. There were significant differences in both the means and standard deviations of RT(clin), RT(compFB), and RT(compNoFB) (F(2,60) = 81.66, P motivation between RT(clin) and RT(compFB), both of which were reported to be more motivating than RT(compNoFB). The stronger correlation between RT(clin) and RT(compFB) as well as the higher reported motivation during RT(clin) and RT(compFB) testing suggest that performance feedback is a positive motivating factor that is inherent to RT(clin) testing. RT(clin) is a simple, inexpensive technique for measuring RT and appears to be an intrinsically motivating task. This motivation may promote faster, more consistent RT performance compared with currently available computerized programs, which do not typically provide performance feedback. Copyright © 2011 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.

Observation of Electronic Excitation Transfer Through Light Harvesting Complex II Using Two-Dimensional Electronic-Vibrational Spectroscopy

Energy Technology Data Exchange (ETDEWEB)

Lewis, NHC; Gruenke, NL; Oliver, TAA; Ballottari, M; Bassi, R; Fleming, GR

2016-10-05

Light-harvesting complex II (LHCII) serves a central role in light harvesting for oxygenic photosynthesis and is arguably the most important photosynthetic antenna complex. In this article, we present two-dimensional electronic–vibrational (2DEV) spectra of LHCII isolated from spinach, demonstrating the possibility of using this technique to track the transfer of electronic excitation energy between specific pigments within the complex. We assign the spectral bands via comparison with the 2DEV spectra of the isolated chromophores, chlorophyll a and b, and present evidence that excitation energy between the pigments of the complex are observed in these spectra. Lastly, we analyze the essential components of the 2DEV spectra using singular value decomposition, which makes it possible to reveal the relaxation pathways within this complex.

multiPDEVS: A Parallel Multicomponent System Specification Formalism

Directory of Open Access Journals (Sweden)

Damien Foures

2018-01-01

Full Text Available Based on multiDEVS formalism, we introduce multiPDEVS, a parallel and nonmodular formalism for discrete event system specification. This formalism provides combined advantages of PDEVS and multiDEVS approaches, such as excellent simulation capabilities for simultaneously scheduled events and components able to influence each other using exclusively their state transitions. We next show the soundness of the formalism by giving a construction showing that any multiPDEVS model is equivalent to a PDEVS atomic model. We then present the simulation procedure associated, usually called abstract simulator. As a well-adapted formalism to express cellular automata, we finally propose to compare an implementation of multiPDEVS formalism with a more classical Cell-DEVS implementation through a fire spread application.

Association between canine leishmaniosis and Ehrlichia canis co-infection: a prospective case-control study.

Science.gov (United States)

Attipa, Charalampos; Solano-Gallego, Laia; Papasouliotis, Kostas; Soutter, Francesca; Morris, David; Helps, Chris; Carver, Scott; Tasker, Séverine

2018-03-20

In the Mediterranean basin, Leishmania infantum is a major cause of disease in dogs, which are frequently co-infected with other vector-borne pathogens (VBP). However, the associations between dogs with clinical leishmaniosis (ClinL) and VBP co-infections have not been studied. We assessed the risk of VBP infections in dogs with ClinL and healthy controls. We conducted a prospective case-control study of dogs with ClinL (positive qPCR and ELISA antibody for L. infantum on peripheral blood) and clinically healthy, ideally breed-, sex- and age-matched, control dogs (negative qPCR and ELISA antibody for L. infantum on peripheral blood) from Paphos, Cyprus. We obtained demographic data and all dogs underwent PCR on EDTA-blood extracted DNA for haemoplasma species, Ehrlichia/Anaplasma spp., Babesia spp., and Hepatozoon spp., with DNA sequencing to identify infecting species. We used logistic regression analysis and structural equation modelling (SEM) to evaluate the risk of VBP infections between ClinL cases and controls. From the 50 enrolled dogs with ClinL, DNA was detected in 24 (48%) for Hepatozoon spp., 14 (28%) for Mycoplasma haemocanis, 6 (12%) for Ehrlichia canis and 2 (4%) for Anaplasma platys. In the 92 enrolled control dogs, DNA was detected in 41 (45%) for Hepatozoon spp., 18 (20%) for M. haemocanis, 1 (1%) for E. canis and 3 (3%) for A. platys. No Babesia spp. or "Candidatus Mycoplasma haematoparvum" DNA was detected in any dog. No statistical differences were found between the ClinL and controls regarding age, sex, breed, lifestyle and use of ectoparasitic prevention. A significant association between ClinL and E. canis infection (OR = 12.4, 95% CI: 1.5-106.0, P = 0.022) was found compared to controls by multivariate logistic regression. This association was confirmed using SEM, which further identified that younger dogs were more likely to be infected with each of Hepatozoon spp. and M. haemocanis, and dogs with Hepatozoon spp. were more likely to

Clinician-Reported Outcome Assessments of Treatment Benefit: Report of the ISPOR Clinical Outcome Assessment Emerging Good Practices Task Force.

Science.gov (United States)

Powers, John H; Patrick, Donald L; Walton, Marc K; Marquis, Patrick; Cano, Stefan; Hobart, Jeremy; Isaac, Maria; Vamvakas, Spiros; Slagle, Ashley; Molsen, Elizabeth; Burke, Laurie B

2017-01-01

A clinician-reported outcome (ClinRO) assessment is a type of clinical outcome assessment (COA). ClinRO assessments, like all COAs (patient-reported, observer-reported, or performance outcome assessments), are used to 1) measure patients' health status and 2) define end points that can be interpreted as treatment benefits of medical interventions on how patients feel, function, or survive in clinical trials. Like other COAs, ClinRO assessments can be influenced by human choices, judgment, or motivation. A ClinRO assessment is conducted and reported by a trained health care professional and requires specialized professional training to evaluate the patient's health status. This is the second of two reports by the ISPOR Clinical Outcomes Assessment-Emerging Good Practices for Outcomes Research Task Force. The first report provided an overview of COAs including definitions important for an understanding of COA measurement practices. This report focuses specifically on issues related to ClinRO assessments. In this report, we define three types of ClinRO assessments (readings, ratings, and clinician global assessments) and describe emerging good measurement practices in their development and evaluation. The good measurement practices include 1) defining the context of use; 2) identifying the concept of interest measured; 3) defining the intended treatment benefit on how patients feel, function, or survive reflected by the ClinRO assessment and evaluating the relationship between that intended treatment benefit and the concept of interest; 4) documenting content validity; 5) evaluating other measurement properties once content validity is established (including intra- and inter-rater reliability); 6) defining study objectives and end point(s) objectives, and defining study end points and placing study end points within the hierarchy of end points; 7) establishing interpretability in trial results; and 8) evaluating operational considerations for the implementation of

Somatic cancer variant curation and harmonization through consensus minimum variant level data

Directory of Open Access Journals (Sweden)

Deborah I. Ritter

2016-11-01

Full Text Available Abstract Background To truly achieve personalized medicine in oncology, it is critical to catalog and curate cancer sequence variants for their clinical relevance. The Somatic Working Group (WG of the Clinical Genome Resource (ClinGen, in cooperation with ClinVar and multiple cancer variant curation stakeholders, has developed a consensus set of minimal variant level data (MVLD. MVLD is a framework of standardized data elements to curate cancer variants for clinical utility. With implementation of MVLD standards, and in a working partnership with ClinVar, we aim to streamline the somatic variant curation efforts in the community and reduce redundancy and time burden for the interpretation of cancer variants in clinical practice. Methods We developed MVLD through a consensus approach by i reviewing clinical actionability interpretations from institutions participating in the WG, ii conducting extensive literature search of clinical somatic interpretation schemas, and iii survey of cancer variant web portals. A forthcoming guideline on cancer variant interpretation, from the Association of Molecular Pathology (AMP, can be incorporated into MVLD. Results Along with harmonizing standardized terminology for allele interpretive and descriptive fields that are collected by many databases, the MVLD includes unique fields for cancer variants such as Biomarker Class, Therapeutic Context and Effect. In addition, MVLD includes recommendations for controlled semantics and ontologies. The Somatic WG is collaborating with ClinVar to evaluate MVLD use for somatic variant submissions. ClinVar is an open and centralized repository where sequencing laboratories can report summary-level variant data with clinical significance, and ClinVar accepts cancer variant data. Conclusions We expect the use of the MVLD to streamline clinical interpretation of cancer variants, enhance interoperability among multiple redundant curation efforts, and increase submission of

Accuracy of Invisalign® treatments in the anterior tooth region. First results.

Science.gov (United States)

Krieger, Elena; Seiferth, Jörg; Saric, Ivana; Jung, Britta A; Wehrbein, Heinrich

2011-03-01

To analyse (a) to what extent the pretreatment model at the beginning of the treatment corresponds to the initial position in the ClinCheck® and (b) to what extent the predicted treatment result corresponds to the actual result of the therapy at the end of the treatment. Pre- and posttreatment models as well as the initial and final position of the ClinCheck with a total of 35 patients aged between 15 and 59 were measured; all of whom were treated by using the Invisalign® technology (Invisalign®, Align Technology, S.C., Calif., USA). The measurement of the initial and final models was conducted by using an electronic digital calliper rule, i.e. that of ClinCheck® using the measurement tool ToothMeasure® of Invisalign® Software. The following parameters in the anterior region were measured: Overjet, Overbite, dental midline shift. Pretreament models and the initial ClinChecks® revealed slight deviations in the parameters overjet 0.08 mm (standard deviation (SD) 0.3), overbite 0.3 mm (SD 0.4) and dental midline deviation 0.1mm (SD 0.4). The final model and the final ClinCheck® revealed larger deviations: the differences for the Overjet were on average 0.4 mm (SD 0.7), Overbite 0.9 mm (SD 0.9) and dental midline shift 0.4 mm (SD 0.5). The IT-based transmission of mal-aligned teeth into the ClinCheck® presentation provides sufficiently good accuracy. Tooth corrections in the vertical plane were more difficult to realize. A vertical overcorrection in the final ClinCheck®, a case refinement at the end of the treatment or additional measures (e.g. horizontal beveled attachments or vertical elastics) seems useful to achieve the individually intended therapeutic goal.

Single Common Powertrain Lubricant Development

Science.gov (United States)

2012-01-01

this particular shortcoming of the current MIL specification lubricant lineup . Perameter: Units: Average Std. Dev. Average Std. Dev. Average...variations of each 0.2-second time block of all engagements. Test Number The run number listed on this report is a random number and is not sequential ...is not sequential . Only SwRI® can link this run number to JDQ-96, L0254054, August 3, 2010. Page 2 of3 John Deere JDQ-96 Performed using 1400

A Study on the Software Quality Assurance Plan

International Nuclear Information System (INIS)

Kim, Hyun Tae

2006-01-01

On 25 August 2006, the CMMI V1.2 (Capability Maturity Model Integration Version 1.2) was released with the new title CMMI-DEV (CMMI for Development) which supersedes the CMMI-SE/SW (CMMI for systems engineering and software engineering) V1.1. This study discusses the application of IEEE Std 730-2002, IEEE Standard for Software Quality Assurance Plans, for the implementation of the Process and Product Quality Assurance (PPQA) process area (PA) of the CMMI-DEV

Performance on Functional Strength Measurement and Muscle Power Sprint Test confirm poor anaerobic capacity in children with Developmental Coordination Disorder.

Science.gov (United States)

Aertssen, Wendy F M; Ferguson, Gillian D; Smits-Engelsman, Bouwien C M

2016-12-01

There is little and conflicting information about anaerobic performance and functional strength in children with Developmental Coordination Disorder (DCD). To investigate anaerobic capacity and functional strength in children with a clinical diagnosis of DCD (clin-DCD) and if differences were larger in older (age 7-10 years) compared to younger children (age 4-6 years). Furthermore to determine the percentage of children with clin-DCD that scored Strength Measurement. A clin-DCD group (36 boys, 11 girls, mean age: 7y 1mo, SD=2y 1mo) and a typically developing group (TD) (57 boys, 53 girls, mean age: 7y 5mo, SD=1y 10mo) were compared on Muscle Power Sprint Test (MPST) and Functional Strength Measurement (FSM). Children with clin-DCD performed poorer on the MPST and FSM, especially on the muscle endurance items of the FSM. The differences were larger in the older children compared to the younger on the cluster muscle endurance and the FSM total score. Over 50% of clin-DCD group scored tested on items requiring fast repetitive movements. Copyright © 2016 Elsevier Ltd. All rights reserved.

Using the Analytical Hierarchy Process (AHP) to evaluate target signatures

CSIR Research Space (South Africa)

Baumbach, J

2009-10-01

Full Text Available .6 12 10.0 0.60 Slide 11 © CSIR 2006 www.csir.co.za G H T S Pattern3 13 9 16 8 9 8 11 3.3 11 4.0 10 2.9 0.92 Pattern4 20 29 26 5 26 29 21 9.2 27 1.7 16 12.1 0.64 CR 38 19 8 31 4 29 4 5 3 λmax 5.00 4.50 4.13 4.83 4.11 4...- ver5 Obser- ver6 Rank Std Dev Rank Std Dev Rank Std Dev 6 Obser- vers W E I Pattern1 63 50 51 62 56 49 58 6.2 53 3.2 62 7.8 -2.27 Pattern2 4 12 7 24 8 14 10 7.1 9 2.6 12 10.0 0.60 Slide 12 © CSIR 2006 www...

Disease: H00101 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available f phagocytic cell disorders. ... JOURNAL ... Curr Opin Allergy Clin Immunol 1:535-40 (2001) ... PMID:19102804 (desc...ncy Diseases Classification Committee. ... JOURNAL ... J Allergy Clin Immunol 120:776-94 (2007) DOI:10.1016/j.jaci.2007.08.053

Erratum to: Evaluating next-generation sequencing for direct clinical diagnostics in diarrhoeal disease

DEFF Research Database (Denmark)

Joensen, Katrine Grimstrup; Engsbro, A. L. Ø.; Lukjancenko, Oksana

2017-01-01

Erratum to: Eur J Clin Microbiol Infect Dis. DOI 10.1007/s10096-017-2947-2 Originally published article contains error.......Erratum to: Eur J Clin Microbiol Infect Dis. DOI 10.1007/s10096-017-2947-2 Originally published article contains error....

Consortium for Bone and Tissue Repair and Regeneration

Science.gov (United States)

2011-01-01

develop the next generation of biomaterials and biosensors. • Developing joint programs to train the next generation of biomedical and biomaterials...nonunions. Clin Orthop Relat Res 205:299-308. Wolfe SA (1982). Autogenous bone grafts versus alloplastic material in maxillofacial surgery. Clin Plast

Friends, friendlessness, and the social consequences of gaining a theory of mind.

Science.gov (United States)

Fink, Elian; Begeer, Sander; Peterson, Candida C; Slaughter, Virginia; de Rosnay, Marc

2015-03-01

Fink, Begeer, Peterson, Slaughter, and de Rosnay (2014) conducted a prospective longitudinal study showing that theory-of-mind (ToM) development at school entry (mean age 5.61 years) significantly predicted friendlessness both concurrently and 2 years later. Friendlessness (defined as lacking any friendship that is mutually reciprocated) is conceptually and empirically distinct from group popularity and independently predicts adverse mental health outcomes throughout life. Here, we respond to the thoughtful commentaries by Wellman (Brit. J. Dev. Psychol, 2015; 33, 24-26), Mizokawa and Koyasu (Brit. J. Dev. Psychol, 2015; 33, 21-23), and Lerner and Lillard (Brit. J. Dev. Psychol, 2015; 33, 18-20) with a focus on three key issues, namely (a) the definition and measurement of friendship, (b) the measurement of advanced ToM development beyond the preschool years, and (c) the exciting future potential for ToM-based training and intervention studies to combat chronic friendlessness. © 2015 The British Psychological Society.

Rapid and Sensitive Detection of Yersinia pestis Using Amplification of Plague Diagnostic Bacteriophages Monitored by Real-Time PCR

Science.gov (United States)

2010-06-01

2004) Development of a bacteriophage phage replication assay for diagnosis of pulmonary tuberculosis . J Clin Microbiol 42: 2115–2120. 30. Abshire TG...Mycobacterium tuberculosis in Mexico . Clin Microbiol 39: 3883–3888. 38. Schofield DA, Westwater C (2009) Phage-mediated bioluminescent detection of

Disease: H00089 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available te immunodeficiencies and their infections. ... JOURNAL ... J Allergy Clin Immunol 113:620-6 (2004) DOI:10.1016/...tic diagnosis of primary immune deficiencies. ... JOURNAL ... Immunol Allergy Clin North Am 28:387-412, x (2008) DOI:10.1016/j.iac.2008.01.004 ...

Metal and Oxide Additives as Agents for Munitions Self-Remediation

Science.gov (United States)

2010-07-01

Std. Dev.: 0.0336 ± 0.0005 4.99 ± 0.56% 1Mass determined by difference as components added to column. 2Mass loss of entire column after...FeNi suites were tested. 1Mass determined by difference as components added to column. 2Mass loss of entire column after extended drying is...0.0963 13.67% Avg. ± Std. Dev.: 0.0971 ± 0.0025 14.38 ± 0.63% 1Mass determined by difference as components added to column. 2Mass loss of

A European randomised controlled trial of the addition of etoposide to standard vincristine and carboplatin induction as part of an 18-month treatment programme for childhood (≤16 years) low grade glioma - A final report.

Science.gov (United States)

Gnekow, Astrid K; Walker, David A; Kandels, Daniela; Picton, Susan; Giorgio Perilongo; Grill, Jacques; Stokland, Tore; Sandstrom, Per Eric; Warmuth-Metz, Monika; Pietsch, Torsten; Giangaspero, Felice; Schmidt, René; Faldum, Andreas; Kilmartin, Denise; De Paoli, Angela; De Salvo, Gian Luca

2017-08-01

The use of chemotherapy to manage newly diagnosed low grade glioma (LGG) was first introduced in the 1980s. One randomised trial has studied two- versus four-drug regimens with a duration of 12 months of treatment after resection. Within the European comprehensive treatment strategy for childhood LGG, the International Society of Paediatric Oncology-Low Grade Glioma (SIOP LGG) Committee launched a randomised trial involving 118 institutions and 11 countries to investigate the addition of etoposide (100 mg/m 2 , days 1, 2 & 3) to a four-course induction of vincristine (1.5 mg/m 2  × 10 wkly) and carboplatin (550 mg/m 2 q 3 weekly) as part of 18-month continuing treatment programme. Patients were recruited after imaging diagnosis, resection or biopsy with progressive disease/symptoms. Some 497 newly diagnosed patients (M/F 231/266; median age 4.26 years (interquartile range (IQR) 2.02-7.06)) were randomised to receive vincristine carboplatin (VC) (n = 249) or VC plus etoposide (VCE) during induction (n = 248), stratified by age and tumour site. No differences between the two arms were found in term of survival and radiological response. Response and non-progression rates at 24 weeks for VC and VCE, were 46% versus 41%, and 93% versus 91% respectively; 5-year Progression-Free Survival (PFS) and Overall Survival (OS) were 46% (StDev 3.5) versus 45% (StDev 3.5) and 89% (StDev 2.1) versus 89% (StDev 2.1) respectively. Age and diencephalic syndrome are adverse clinical risk factors for PFS and OS. 5-year OS for patients in early progression at week 24 were 46% (StDev 13.8) and 49% (StDev 16.5) in the two arms, respectively. The addition of etoposide to VC did not improve PFS or OS. High non-progression rates at 24 weeks justify retaining VC as standard first-line therapy. Infants with diencephalic syndrome and early progression need new treatments to be tested. Future trials should use neurological/visual and toxicity outcomes and be designed to

Development of the male reproductive system in Callinectes ornatus Ordway, 1863 (Brachyura: Portunidae

Directory of Open Access Journals (Sweden)

Fabiana Aparecida do Nascimento

Full Text Available This study describes the histology and histochemistry of the male reproductive system in Callinectes ornatus, comparing juvenile and adult developmental stages. We also analyzed changes in the gonadosomatic (GSI and hepatosomatic (HSI indices, and the weights of the testis and vas deferens during the development. The results showed that all stages, beginning with the juvenile (JUV, through developing (DEV and mature (MAT adult males of C. ornatus produce sperm and spermatophores. During development, testicular lobes showed the same characteristics of production and release of sperm into the seminiferous duct. The vas deferens showed little histological and histochemical change in the epithelium in juvenile and adult males. The differences consisted of the larger amount of secretion in MAT males compared to JUV and DEV ones. The chemical composition of the seminal fluid was similar, but MAT males produced a more homogeneous secretion. Morphological and physiological maturation are not synchronized in C. ornatus, since JUV males produced spermatophores similar to those in DEV and MAT males. However, these JUV are not yet able to reproduce, since they still have the abdomen attached to the cephalothoracic sternum. The increase of the GSI during development was significant for MAT males, and is related to the production of sufficient volume of seminal fluid to form the sperm "plug" in the female seminal receptacle. The HSI decreased from DEV to MAT adult stages, indicating that reserves from the hepatopancreas are used to develop the reproductive system after the pubertal molt.

Change in the reaction kinetics of the deepoxidation of violaxanthine and activity of the xanthophyll ring under the action of γ irradiation

International Nuclear Information System (INIS)

Saakov, V.S.

1993-01-01

This article presents results of a study on the change in the content of the major chloroplast pigments and the activity of the xanthophyll ring as a function of irradiation dose. The data show that photodecomposition of chlorophyll and carotenoids is not associated with the primary action of ionizing radiations but may be manifested as a secondary process which follows inactivation or decomposition of the reaction center. Ionizing radiation affects the activity of the xanthophyll ring, as measured by deepoxidation of violaxanthine (DEV). Disruption of the electron transport chain leads to inhibition of DEV

Production, purification and characterization of polyclonal antibody against the truncated gK of the duck enteritis virus

Directory of Open Access Journals (Sweden)

Zhang Shunchuan

2010-09-01

Full Text Available Abstract Duck virus enteritis (DVE is an acute, contagious herpesvirus infection of ducks, geese, and swans, which has produced significant economic losses in domestic and wild waterfowl. With the purpose of decreasing economic losses in the commercial duck industry, studying the unknown glycoprotein K (gK of DEV may be a new method for preferably preventing and curing this disease. So this is the first time to product and purify the rabbit anti-tgK polyclonal antibody. Through the western blot and ELISA assay, the truncated glycoprotein K (tgK has good antigenicity, also the antibody possesses high specificity and affinity. Meanwhile the rabbit anti-tgK polyclonal antibody has the potential to produce subunit vaccines and the functions of neutralizing DEV and anti-DEV infection because of its neutralization titer. Indirect immunofluorescent microscopy using the purified rabbit anti-tgK polyclonal antibody as diagnostic antibody was susceptive to detect a small quantity of antigen in tissues or cells. This approach also provides effective experimental technology for epidemiological investigation and retrospective diagnose of the preservative paraffin blocks.

Coxsackievirus B4 as a Causative Agent of Diabetes Mellitus Type 1: Is There a Role of Inefficiently Treated Drinking Water and Sewage in Virus Spreading?

Science.gov (United States)

El-Senousy, Waled M; Abdel-Moneim, Adel; Abdel-Latif, Mahmoud; El-Hefnawy, Mohamed H; Khalil, Rehab G

2018-03-01

This study proposed to detect the enterovirus (EV) infection in children with type 1 diabetes mellitus (T1D) and to assess the role of insufficiently treated water and sewage as sources of viral spreading. Three hundred and eighty-two serum specimens of children with T1D, one hundred serum specimens of children who did not suffer from T1D as control, and forty-eight water and sewage samples were screened for EV RNA using nested RT-PCR. The number of genome copies and infectious units of EVs in raw and treated sewage and water samples were investigated using real-time (RT)-PCR and plaque assay, respectively. T1D markers [Fasting blood glucose (FBG), HbA1c, and C-peptide], in addition to anti-Coxsackie A & B viruses (CVs A & B) IgG, were measured in control, T1D-negative EV (T1D-EV - ), and T1D-positive EV (T1D-EV + ) children specimens. The prevalence of EV genome was significantly higher in diabetic children (26.2%, 100 out of 382) than the control children (0%, 0 out of 100). FBG and HbA1c in T1D-EV - and T1D-EV + children specimens were significantly higher than those in the control group, while c-peptide in T1D-EV - and T1D-EV + children specimens was significantly lower than that in the control (n = 100; p water and treated sewage samples was 25 and 33.3%, respectively. The prevalence of EV infectious units in drinking water and treated sewage samples was 8.5 and 25%, respectively. Quantification assays were performed to assess the capabilities of both wastewater treatment plants (WWTPs) and water treatment plants (WTPs) to remove EV. The reduction of EV genome in Zenin WWTP ranged from 2 to 4 log 10 , while the reduction of EV infectious units ranged from 1 to 4 log 10 . The reduction of EV genome in El-Giza WTP ranged from 1 to 3 log 10 , while the reduction of EV infectious units ranged from 1 to 2 log 10 . This capability of reduction did not prevent the appearance of infectious EV in treated sewage and drinking water. Plaque purification was performed

Experiences Supporting the Lunar Reconnaissance Orbiter Camera: the Devops Model

Science.gov (United States)

Licht, A.; Estes, N. M.; Bowman-Cisnesros, E.; Hanger, C. D.

2013-12-01

Introduction: The Lunar Reconnaissance Orbiter Camera (LROC) Science Operations Center (SOC) is responsible for instrument targeting, product processing, and archiving [1]. The LROC SOC maintains over 1,000,000 observations with over 300 TB of released data. Processing challenges compound with the acquisition of over 400 Gbits of observations daily creating the need for a robust, efficient, and reliable suite of specialized software. Development Environment: The LROC SOC's software development methodology has evolved over time. Today, the development team operates in close cooperation with the systems administration team in a model known in the IT industry as DevOps. The DevOps model enables a highly productive development environment that facilitates accomplishment of key goals within tight schedules[2]. The LROC SOC DevOps model incorporates industry best practices including prototyping, continuous integration, unit testing, code coverage analysis, version control, and utilizing existing open source software. Scientists and researchers at LROC often prototype algorithms and scripts in a high-level language such as MATLAB or IDL. After the prototype is functionally complete the solution is implemented as production ready software by the developers. Following this process ensures that all controls and requirements set by the LROC SOC DevOps team are met. The LROC SOC also strives to enhance the efficiency of the operations staff by way of weekly presentations and informal mentoring. Many small scripting tasks are assigned to the cognizant operations personnel (end users), allowing for the DevOps team to focus on more complex and mission critical tasks. In addition to leveraging open source software the LROC SOC has also contributed to the open source community by releasing Lunaserv [3]. Findings: The DevOps software model very efficiently provides smooth software releases and maintains team momentum. Scientists prototyping their work has proven to be very efficient

The Role of IQGAP1 in Breast Carcinoma

Science.gov (United States)

2012-10-01

Robert, N. J., Scholl, S., Feh- renbacher, L., Wolter, J. M., Paton, V., Shak , S., Lieberman, G., and Sla- mon, D. J. (1999) J. Clin. Oncol. 17...Burchmore, M., Shak , S., Stewart, S. J., and Press, M. (2002) J. Clin. Oncol. 20, 719–726 23. Piccart-Gebhart, M. J., Procter, M., Leyland-Jones, B

Measures of the inflammatory response in cryptogenic fibrosing alveolitis

International Nuclear Information System (INIS)

Pantin, C.F.; Valind, S.O.; Sweatman, M.; Lawrence, R.; Rhodes, C.G.; Brudin, L.; Britten, A.; Hughes, J.M.; Turner-Warwick, M.

1988-01-01

Cryptogenic fibrosing alveolitis (CFA) is characterized by interstitial fibrosis and parenchymal inflammation. Eleven patients with CFA (10 proved by lung biopsy) were followed over 2 yr using clinical symptoms, radiographic change, and pulmonary function tests to adjust their treatment. Lung lavage, positron camera (PET) measurements of regional extravascular lung density (Dev), pulmonary blood volume (Vb), and the metabolic rate for 18F-deoxyglucose (MRglc), clearance of 99mTc-diethylenetriaminepentacetate (99mTc-DTPA) aerosol, and lung uptake of 67Ga were measured initially and at the end of the first year to give a profile of the inflammatory response. Compared with normal subjects, there was an increased percentage of neutrophils and eosinophils in the lung lavage, increased Dev (p less than 0.002) with no significant difference in Vb, increased MRglc (p less than 0.02), 99mTc-DTPA clearance (p less than 0.002), and 67Ga uptake (p less than 0.02). The smallest increases in Dev were seen in the two patients with most destruction shown by lung biopsy. There were inverse correlations between Dev and both FVC and TLC, but a direct correlation between Vb and transfer factor. 99mTc-DTPA clearance changed concordantly with clinical status and radiographic and respiratory function changes during the first year. If glucose utilization (MRglc) remained in the normal range between the initial and first yearly assessment, the patient improved or remained stable during the second year as shown by clinical status and radiographic and respiratory function measurements. If it rose or remained high, the patient's condition deteriorated

Differences between individual and societal health state valuations: any link with personality?

Science.gov (United States)

Chapman, Benjamin P; Franks, Peter; Duberstein, Paul R; Jerant, Anthony

2009-08-01

The concept of "adaptation" has been proposed to account for differences between individual and societal valuations of specific health states in patients with chronic diseases. Little is known about psychological indices of adaptational capacity, which may predict differences in individual and societal valuations of health states. We investigated whether such differences were partially explained by personality traits in chronic disease patients. Analysis of baseline data of randomized controlled trial. Three hundred seventy patients with chronic disease. The NEO-five factor inventory measure of personality, EuroQoL-5D (EQ-5D) societal-based, and the EQ visual analogue scale individually-based measures of health valuation. Regression analyses modeled Dev, a measure of difference between the EQ-Visual Analogue Scale and EQ-5D, as a function of personality traits, sociodemographic factors, and chronic diseases. Individual valuations were significantly and clinically higher than societal valuations among patients in the second and third quartile of conscientiousness (Dev = 0.08, P = 0.01); among covariates, only depression (Dev = -0.04, P = 0.046) was also associated with Dev. Compared with societal valuations of a given health state, persons at higher quartiles of conscientiousness report less disutility associated with poor health. The effect is roughly twice that of some estimates of minimally important clinical differences on the EQ-5D and of depression. Although useful at the aggregate level, societal preference measures may systematically undervalue the health states of more conscientious individuals. Future work should examine the impact this has on individual patient outcome evaluation in clinical studies.

Travelers’ Diarrhea Diagnosis and Therapy Study in United States Military Personnel on Short-Term Deployment in Thailand

Science.gov (United States)

2004-01-01

Kirkley BA, Vetter EA, Cockerill FR, 3rd and Procop GW. Evaluation of the Alexon-trend ProSpecT Campylobacter microplate assay. J Clin Microbiol 2000;38...Lake City area. J Clin Microbiol 2000;38:3076-9 30. Tolcin R, LaSalvia MM, Kirkley BA, Vetter EA, Cockerill FR, 3rd and Procop GW. Evaluation of the

A Critical Review of the Drug/Performance Literature. Volume II.

Science.gov (United States)

1979-12-01

Cannabis Drug Tolerance Drugs and Stress Amphetamine Depressants Drug Users Ethanol Behavior Drug Abuse Drug Withdrawal Hallucinogens Cannabinoids Drug...Therapeutics Clin Tox Clinical Toxicology Couw Psychopharm Communications in Psychopharmacology Comp Psychiat Comprehensive Psychiatry Current Ther Res Current...European Journal of Toxicology Exp Neurol Experimental Neurology EEG Clin Neurophys EEG Clinical Neurophysiology EEG J EEG Journal Ger Med German Medicine

Photocarcinogenesis and toxicity of benzoyl peroxide in hairless mice after simulated solar radiation

DEFF Research Database (Denmark)

Lerche, Catharina M; Philipsen, Peter A; Poulsen, Thomas

2010-01-01

hairless female C3.Cg/TifBomTac-immunocompetent mice. BPO or BPO-clin was applied topically to the back five times each week, followed by SSR three times each week (2, 3, or 4 standard erythema doses) 3-4 h later, for 365 days or until death. Generally BPO and BPO-clin did not accelerate the time to first...

Low Ultraviolet B and Increased Risk of Brain Cancer: An Ecological Study of 175 Countries

Science.gov (United States)

2009-07-01

Mean Author Year Journal Location 25(OH)D ng/ml Mazess et al. 1985 Am J Clin Nutr Alaska, USA 16.6 Oliveri et al. 1990 Medicina Buenos Aires...Clin Nutr USA 32.9 Rucker et al. 2002 Cmaj Calgary, Canada 23.8 Tangpricha et al. 2002 Am J Med USA 29.1 Fassi et al. 2003 Medicina Buenos Aires

Vitamin D Supplementation in Submariners

Science.gov (United States)

2008-12-02

including diabetes mellitus type 1, rheumatoid arthritis , experimental autoimmune encephalomyelitis, inflammatory bowel disease, and systemic lupus...the safety and effectiveness of monthly ergocalciferol in hemodialysis patients . Nephron Clin Pract 2007;105(3):132-8 91. Goldzieher JW, Zerwekh...D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin Proc 2003;78:1463-1470. 31. Glerup H, Mikkelsen K, Poulsen L, et al

Differences Between Individual and Societal Health State Valuations

Science.gov (United States)

Chapman, Benjamin P.; Franks, Peter; Duberstein, Paul R.; Jerant, Anthony

2009-01-01

Objective The concept of “adaptation” has been proposed to account for differences between individual and societal valuations of specific health states in patients with chronic diseases. Little is known about psychological indices of adaptational capacity, which may predict differences in individual and societal valuations of health states. We investigated whether such differences were partially explained by personality traits in chronic disease patients. Research Design Analysis of baseline data of randomized controlled trial. Subjects Three hundred seventy patients with chronic disease. Measures The NEO-five factor inventory measure of personality, EuroQoL-5D (EQ-5D) societal-based, and the EQ visual analogue scale individually-based measures of health valuation. Results Regression analyses modeled Dev, a measure of difference between the EQ-Visual Analogue Scale and EQ-5D, as a function of personality traits, sociodemographic factors, and chronic diseases. Individual valuations were significantly and clinically higher than societal valuations among patients in the second and third quartile of conscientiousness (Dev = 0.08, P = 0.01); among covariates, only depression (Dev = -0.04, P = 0.046) was also associated with Dev. Conclusion Compared with societal valuations of a given health state, persons at higher quartiles of conscientiousness report less disutility associated with poor health. The effect is roughly twice that of some estimates of minimally important clinical differences on the EQ-5D and of depression. Although useful at the aggregate level, societal preference measures may systematically undervalue the health states of more conscientious individuals. Future work should examine the impact this has on individual patient outcome evaluation in clinical studies. PMID:19543121

A method for the direct measurement of electronic site populations in a molecular aggregate using two-dimensional electronic-vibrational spectroscopy

Energy Technology Data Exchange (ETDEWEB)

Lewis, Nicholas H. C.; Dong, Hui; Oliver, Thomas A. A.; Fleming, Graham R., E-mail: grfleming@lbl.gov [Department of Chemistry, University of California, Berkeley, California 94720 (United States); Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States); Kavli Energy Nanosciences Institute at Berkeley, Berkeley, California 94720 (United States)

2015-09-28

Two dimensional electronic spectroscopy has proved to be a valuable experimental technique to reveal electronic excitation dynamics in photosynthetic pigment-protein complexes, nanoscale semiconductors, organic photovoltaic materials, and many other types of systems. It does not, however, provide direct information concerning the spatial structure and dynamics of excitons. 2D infrared spectroscopy has become a widely used tool for studying structural dynamics but is incapable of directly providing information concerning electronic excited states. 2D electronic-vibrational (2DEV) spectroscopy provides a link between these domains, directly connecting the electronic excitation with the vibrational structure of the system under study. In this work, we derive response functions for the 2DEV spectrum of a molecular dimer and propose a method by which 2DEV spectra could be used to directly measure the electronic site populations as a function of time following the initial electronic excitation. We present results from the response function simulations which show that our proposed approach is substantially valid. This method provides, to our knowledge, the first direct experimental method for measuring the electronic excited state dynamics in the spatial domain, on the molecular scale.

Synergistic Actions of Pyridostigmine Bromide and Insecticides on Muscle and Vascular Nociceptors

Science.gov (United States)

2014-01-01

were consistent with the Ethical Guidelines for Pain Research. Results: Following exposure to permethrin, action potential (AP) duration was greatly... osteoarthritis synovium. Clin Rheumatol 27, 1127-1134. Petruska, J. C., Napaporn, J., Johnson, R. D., and Cooper, B. Y. (2002). Chemical...with Gulf War Veterans’ Illness and joint pain compared to normal and osteoarthritis synovium. Clin Rheumatol. 2008;27:1127-34. Petruska JC, Napaporn

DevOps for network function virtualisation: an architectural approach

OpenAIRE

Karl, H.; Draexler, S.; Peuster, M.; Galis, A.; Bredel, M.; Ramos, A.; Martrat, J.; Siddiqui, M. S.; Van Rossem, S.; Tavernier, W.; Xilouris, G.

2016-01-01

The Service Programming and Orchestration for Virtualised Software Networks (SONATA) project targets both the flexible programmability of software networks and the optimisation of their deployments by means of integrating Development and Operations in order to accelerate industry adoption of software networks and reduce time-to-market for networked services. SONATA supports network function chaining and orchestration, making service platforms modular and easier to customise to the needs of di...

Synthesis and characterization of Zinc (II)-loaded Zeolite/Graphene oxide nanocomposite as a new drug carrier

Energy Technology Data Exchange (ETDEWEB)

Khatamian, M. [Inorganic Chemistry Department, Faculty of Chemistry, University of Tabriz, C.P. 51664 Tabriz (Iran, Islamic Republic of); Divband, B., E-mail: baharakdivband@yahoo.com [Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz (Iran, Islamic Republic of); Inorganic Chemistry Department, Faculty of Chemistry, University of Tabriz, C.P. 51664 Tabriz (Iran, Islamic Republic of); Farahmand-zahed, F. [Inorganic Chemistry Department, Faculty of Chemistry, University of Tabriz, C.P. 51664 Tabriz (Iran, Islamic Republic of)

2016-09-01

Current research has focused on the preparation of Zinc-clinoptilolite/Graphene Oxide (Zn-Clin/GO) hybrid nanostructure and investigating its biocompatibility for the first time. As prepared samples were characterized by X-ray diffraction (XRD), Scanning electron microscopy (SEM), Thermo gravimetric analysis (TGA) and Fourier transform infrared (FT-IR). In order to use it as a drug carrier two important factors were investigated: cytocompatibility of nanocomposites and their drug loading capacity. The results showed that the prepared nanocomposite is cytocompatible and its high loading capacity and slow release performance for Doxorubicin (DOX), as a cancer drug, proved that it can be used as a drug carrier. At last in-vitro toxicity of DOX loaded nanocomposite was compared with pure DOX. - Graphical abstract: Biocompatible Zn-clinoptilolite/Graphene oxide hybrid nanostructure as in vitro drug delivery systems (DDS) was able to store and release substantial amounts of doxorubicin to the lung cancer cell lines. Display Omitted - Highlights: • Zn-Clin/GO nanocomposite as a new in vitro drug carrier with high loading capacity is synthesized. • Two synthesis methods (Microwave assisted hydrothermal method and Reflux method) are used. • All of the carriers (Zn-Clin, Zn-Clin/GO, GO) showed high biocompatibility.

Synthesis and characterization of Zinc (II)-loaded Zeolite/Graphene oxide nanocomposite as a new drug carrier

International Nuclear Information System (INIS)

Khatamian, M.; Divband, B.; Farahmand-zahed, F.

2016-01-01

Current research has focused on the preparation of Zinc-clinoptilolite/Graphene Oxide (Zn-Clin/GO) hybrid nanostructure and investigating its biocompatibility for the first time. As prepared samples were characterized by X-ray diffraction (XRD), Scanning electron microscopy (SEM), Thermo gravimetric analysis (TGA) and Fourier transform infrared (FT-IR). In order to use it as a drug carrier two important factors were investigated: cytocompatibility of nanocomposites and their drug loading capacity. The results showed that the prepared nanocomposite is cytocompatible and its high loading capacity and slow release performance for Doxorubicin (DOX), as a cancer drug, proved that it can be used as a drug carrier. At last in-vitro toxicity of DOX loaded nanocomposite was compared with pure DOX. - Graphical abstract: Biocompatible Zn-clinoptilolite/Graphene oxide hybrid nanostructure as in vitro drug delivery systems (DDS) was able to store and release substantial amounts of doxorubicin to the lung cancer cell lines. Display Omitted - Highlights: • Zn-Clin/GO nanocomposite as a new in vitro drug carrier with high loading capacity is synthesized. • Two synthesis methods (Microwave assisted hydrothermal method and Reflux method) are used. • All of the carriers (Zn-Clin, Zn-Clin/GO, GO) showed high biocompatibility.

Internal Prosthetic Replacement of Skeletal Segments Lost in Combat Injuries.

Science.gov (United States)

1973-08-31

osteo- articular bone grafts. Clin. Ortho., 87: 156, 1972. 8. Tuli, S. M.: Bridging of bone defects by massive bone grafts in tumorous conditions. Clin...fashion in its proximal one-third to "prevent distractic ,n of the fragments. The fiber metal segment was then placed in the appropriate defect and the...defect slightly oversized and also osteotomizing the fibula to delete any possible distracting forces or angulating forces. The only complication in

Trials with TALL-1O4 Cells for Treatment of Metastatic Breast Cancer

Science.gov (United States)

1999-10-01

Cesano, A.*, Jeglum, K. A., and Santoli, D. Adjuvant treatment of canine osteosarcoma with the human cytotoxic T cell line TALL-104. Clin. Cancer... canine malignant histiocytosis with the human MHC non-restricted cytotoxic T cell line TALL-104. Clin. Cancer Res., 3: 1789-1797, 1997. 14. Visonneau, S...Visonneau, S., Cesano, A., Jeglum, K. A., and Santoli, D. Adoptive therapy of canine metastatic mammary carcinoma with the human MHC non-restricted

Evaluation of Erythrocyte Sodium-22 Influx as a Laboratory Test for the Diagnosis of Essential Hypertension.

Science.gov (United States)

1982-12-01

hyperten- sion. Clin. Sci. (suppl) 61:13s-15s, 1981. 8. Canessa, M., Adragna , N., Solomon, H.S., Connolly, T.M., and Tosteson, D.C. Increased sodium...H., Adragna , N., Tosteson, D.C., Dagher, G., Garay, R., and Meyer, P. Na counter- transport and cotransport in human red cells: function...reference range for apparently healthy adults. Clin. Chem. 23:275-278, 1977. 16. Garay, R., Adragna , N., Canessa, M., and Tosteson, D. Outward sodium

A compact pre-processor system for the ATLAS level-1 calorimeter trigger

CERN Document Server

Pfeiffer, U

1999-01-01

This thesis describ es the researc h whose aim is to dev elop a compact Pre-Pro cessor system for the A TLAS Lev el-1 Calorimeter T rigger. Con tributions to the p erformance and the arc hitecture of the Pre-Pro cessor w ere made. A demonstrator Multi-Chip Mo dule (PPrD- MCM) w as dev elop ed and assem bled whic h p erforms most of the prepro cessing of four analogue trigger-to w er signals. The prepro cessing includes digitisation to 8-bit precision, iden ti cation of the corresp onding bunc h-crossing in time (BCID), calibration of the transv erse energy , readout of ra w trigger data, and high-sp eed serial data transmission to the trigger pro cessors. The demonstrator Multi-Chip Mo dule has a size of 15.9 cm 2 and it consists of 9 dies. The MCM w as designed with a smallest feature size of 100 m and it w as fabricated in a laminated MCM-L pro cess o ered b yW urth Elektronik. A Flip-Chip in terconnection ASIC (Finco) w as dev elop ed for the PPrD-MCM and fabricated in a 0.8 m BiCMOS- pro cess o ered b ...

AA2024 Alüminyum Alaşımının Sürtünme Karıştırma Kaynağında Farklı Parametrelerin Mekanik Özelliklere Etkisinin İncelenmesi

Directory of Open Access Journals (Sweden)

Aydın ŞIK

2010-02-01

Full Text Available Bu çalışmada, genel özelliği hafifliği, işlenebilirliği, yüksek korozyon dayancı, yüksek dayanıma sahip olmasından dolayı kullanım alanı olarak özellikle uçak gövdelerinde ve kanatlarda ve otomotiv endüstrilerinde kullanılan AA2024 alaşımı sürtünme karıştırma kaynağı yöntemi ile birleştirilerek, oluşan bağlantıların yorulma, sertlik, eğme ve çekme deneyleri incelenmiştir. 4 mm kalınlığındaki levhaların kaynak esnasında kaynak ilerleme hızı ve karıştırıcı ucun dönme devri değişken parametreler olarak belirlenmiştir. Bu parametreler; 20 mm omuz genişliği, devir sayısı 1000 dev/dak, 1500 dev/dak, 2500 dev/dak ve ilerleme hızları 120 mm/dak ve 200 mm/ dak olarak alınmıştır.

Identification of a spliced gene from duck enteritis virus encoding a protein homologous to UL15 of herpes simplex virus 1

Directory of Open Access Journals (Sweden)

Wang Yu

2011-04-01

Full Text Available Abstract Background In herpesviruses, UL15 homologue is a subunit of terminase complex responsible for cleavage and packaging of the viral genome into pre-assembled capsids. However, for duck enteritis virus (DEV, the causative agent of duck viral enteritis (DVE, the genomic sequence was not completely determined until most recently. There is limited information of this putative spliced gene and its encoding protein. Results DEV UL15 consists of two exons with a 3.5 kilobases (kb inron and transcribes into two transcripts: the full-length UL15 and an N-terminally truncated UL15.5. The 2.9 kb UL15 transcript encodes a protein of 739 amino acids with an approximate molecular mass of 82 kiloDaltons (kDa, whereas the UL15.5 transcript is 1.3 kb in length, containing a putative 888 base pairs (bp ORF that encodes a 32 kDa product. We also demonstrated that UL15 gene belonged to the late kinetic class as its expression was sensitive to cycloheximide and phosphonoacetic acid. UL15 is highly conserved within the Herpesviridae, and contains Walker A and B motifs homologous to the catalytic subunit of the bacteriophage terminase as revealed by sequence analysis. Phylogenetic tree constructed with the amino acid sequences of 23 herpesvirus UL15 homologues suggests a close relationship of DEV to the Mardivirus genus within the Alphaherpesvirinae. Further, the UL15 and UL15.5 proteins can be detected in the infected cell lysate but not in the sucrose density gradient-purified virion when reacting with the antiserum against UL15. Within the CEF cells, the UL15 and/or UL15.5 localize(s in the cytoplasm at 6 h post infection (h p. i. and mainly in the nucleus at 12 h p. i. and at 24 h p. i., while accumulate(s in the cytoplasm in the absence of any other viral protein. Conclusions DEV UL15 is a spliced gene that encodes two products encoded by 2.9 and 1.3 kb transcripts respectively. The UL15 is expressed late during infection. The coding sequences of DEV UL15

Identification of a spliced gene from duck enteritis virus encoding a protein homologous to UL15 of herpes simplex virus 1.

Science.gov (United States)

Zhu, Hongwei; Li, Huixin; Han, Zongxi; Shao, Yuhao; Wang, Yu; Kong, Xiangang

2011-04-06

In herpesviruses, UL15 homologue is a subunit of terminase complex responsible for cleavage and packaging of the viral genome into pre-assembled capsids. However, for duck enteritis virus (DEV), the causative agent of duck viral enteritis (DVE), the genomic sequence was not completely determined until most recently. There is limited information of this putative spliced gene and its encoding protein. DEV UL15 consists of two exons with a 3.5 kilobases (kb) inron and transcribes into two transcripts: the full-length UL15 and an N-terminally truncated UL15.5. The 2.9 kb UL15 transcript encodes a protein of 739 amino acids with an approximate molecular mass of 82 kiloDaltons (kDa), whereas the UL15.5 transcript is 1.3 kb in length, containing a putative 888 base pairs (bp) ORF that encodes a 32 kDa product. We also demonstrated that UL15 gene belonged to the late kinetic class as its expression was sensitive to cycloheximide and phosphonoacetic acid. UL15 is highly conserved within the Herpesviridae, and contains Walker A and B motifs homologous to the catalytic subunit of the bacteriophage terminase as revealed by sequence analysis. Phylogenetic tree constructed with the amino acid sequences of 23 herpesvirus UL15 homologues suggests a close relationship of DEV to the Mardivirus genus within the Alphaherpesvirinae. Further, the UL15 and UL15.5 proteins can be detected in the infected cell lysate but not in the sucrose density gradient-purified virion when reacting with the antiserum against UL15. Within the CEF cells, the UL15 and/or UL15.5 localize(s) in the cytoplasm at 6 h post infection (h p. i.) and mainly in the nucleus at 12 h p. i. and at 24 h p. i., while accumulate(s) in the cytoplasm in the absence of any other viral protein. DEV UL15 is a spliced gene that encodes two products encoded by 2.9 and 1.3 kb transcripts respectively. The UL15 is expressed late during infection. The coding sequences of DEV UL15 are very similar to those of alphaherpesviruses and

A novel measure of ewe efficiency for breeding and benchmarking purposes.

Science.gov (United States)

McHugh, N; Pabiou, T; McDermott, K; Wall, E; Berry, D P

2018-04-19

Ewe efficiency has traditionally been defined as the ratio of litter weight to ewe weight; given the statistical properties of ratio traits, an alternative strategy is proposed in the present study. The concept of using the deviation in performance of an animal from the population norm has grown in popularity as a measure of animal-level efficiency. The objective of the present study was to define novel measures of efficiency for sheep which considers the combined weight of a litter of lambs relative to the weight of their dam, and vice versa. Two novel traits, representing the deviation in total litter weight at 40 d (DEV40L) or weaning (DEVweanL), was calculated from the residuals of a statistical model, with litter weight as the dependent variable and with the fixed effects of litter rearing size, contemporary group and ewe weight. The deviation in ewe weight at 40 d post lambing (DEV40E) or weaning (DEVweanE) was derived using a similar approach but with ewe weight and litter weight interchanged as the dependent variable. Variance components for each trait were estimated by first deriving the litter or ewe weight deviation phenotype and subsequently estimating the variance components. The phenotypic SD in DEV40L and DEVweanL was 8.46 kg and 15.37 kg, respectively; the mean litter weight at 40 d and weaning was 30.97 kg and 47.68 kg, respectively. The genetic SD and heritability for DEV40L was 2.65 kg and 0.12, respectively. For DEVweanL, the genetic SD and heritability was 4.94 kg and 0.13, respectively. The average ewe weight at 40 d post lambing and at weaning was 66.43 kg and 66.87 kg, respectively. The genetic SD and heritability for DEV40E was 4.33 kg and 0.24. The heritability estimated for DEVweanE was 0.31. The traits derived in the present study may be useful for phenotypic benchmarking of ewes within flock on performance but also for benchmarking flocks against each other; furthermore the extent of genetic variability in all traits, coupled with the

Pathophysiology of Heat-Related Illnesses

Science.gov (United States)

2012-01-01

Figure 10-4). deHydrATion And elecTrolyTe imBAlAnce Water requirements during heat exposure are primarily deter- mined by a person’s sweat losses. Water...the effect of cyclooxygenase inhibition, J Clin Invest 81:1162, 1988. 241. Opal SM, Fisher CJ Jr, Dhainaut JF, et al: Confirmatory interleukin-1...inhibition, J Clin Invest 81:1162, 1988. 241. Opal SM, Fisher CJ Jr, Dhainaut JF, et al: Confirmatory interleukin-1 receptor antagonist trial in severe

Prostate Cancer Clinical Consortium Clinical Research Site: Targeted Therapies

Science.gov (United States)

2017-10-01

prostate cancer . Cancer Res 70: 7992-8002, 2010 8. Nelson PS: Molecular states underlying an- drogen receptor activation: A framework for thera- peutics...targeting androgen signaling in prostate cancer . J Clin Oncol 30:644-646, 2012 9. Thadani-Mulero M, Nanus DM, Giannakakou P: Androgen receptor on the... prostate cancer . Clin Cancer Res 21:795-807, 2015 17. van Soest RJ, de Morrée ES, Kweldam CF, et al: Targeting the androgen receptor confers in vivo

Connected vehicle pilot deployment program.

Science.gov (United States)

2014-01-01

The U.S. Department of Transportations (USDOTs) connected vehicle research : program is a multimodal initiative to enable safe, interoperable, networked wireless : communications among vehicles, infrastructure, and personal communications : dev...

Alternate Material Pallet, 40" x 48", MIL-STD-1660, Engineering Evaluation Tests

National Research Council Canada - National Science Library

Dugan, Jeffery

2003-01-01

The U.S. Army Defense Ammunition Center (DAC), Validation Engineering Division (SJMAC-DEV) conducted Engineering Evaluation Tests to determine if the Alternate Material Pallet manufactured by Hunter Paine Enterprise, Inc...

An adaptive radiotherapy planning strategy for bladder cancer using deformation vector fields

International Nuclear Information System (INIS)

Vestergaard, Anne; Kallehauge, Jesper Folsted; Petersen, Jørgen Breede Baltzer; Høyer, Morten; Søndergaard, Jimmi; Muren, Ludvig Paul

2014-01-01

Purpose: Adaptive radiotherapy (ART) has considerable potential in treatment of bladder cancer due to large inter-fractional changes in shape and size of the target. The aim of this study was to compare our clinically applied method for plan library creation that involves manual bladder delineations (Clin-ART) with a method using the deformation vector fields (DVFs) resulting from intensity-based deformable image registrations (DVF-based ART). Materials and methods: The study included thirteen patients with urinary bladder cancer who had daily cone beam CTs (CBCTs) acquired for set-up. In both ART strategies investigated, three plan selection volumes were generated using the CBCTs from the first four fractions; in Clin-ART boolean combinations of delineated bladders were used, while the DVF-based strategy applied combinations of the mean and standard deviation of patient-specific DVFs. The volume ratios (VRs) of the course-averaged PTV for the two ART strategies relative the non-adaptive PTV were calculated. Results: Both Clin-ART and DVF-based ART considerably reduced the course-averaged PTV, compared to non-adaptive RT. The VR for DVF-based ART was lower than for Clin-ART (0.65 vs. 0.73; p < 0.01). Conclusions: DVF-based ART for bladder irradiation has a considerable normal tissue sparing potential surpassing our already highly conformal clinically applied ART strategy

An adaptive radiotherapy planning strategy for bladder cancer using deformation vector fields.

Science.gov (United States)

Vestergaard, Anne; Kallehauge, Jesper Folsted; Petersen, Jørgen Breede Baltzer; Høyer, Morten; Søndergaard, Jimmi; Muren, Ludvig Paul

2014-09-01

Adaptive radiotherapy (ART) has considerable potential in treatment of bladder cancer due to large inter-fractional changes in shape and size of the target. The aim of this study was to compare our clinically applied method for plan library creation that involves manual bladder delineations (Clin-ART) with a method using the deformation vector fields (DVFs) resulting from intensity-based deformable image registrations (DVF-based ART). The study included thirteen patients with urinary bladder cancer who had daily cone beam CTs (CBCTs) acquired for set-up. In both ART strategies investigated, three plan selection volumes were generated using the CBCTs from the first four fractions; in Clin-ART boolean combinations of delineated bladders were used, while the DVF-based strategy applied combinations of the mean and standard deviation of patient-specific DVFs. The volume ratios (VRs) of the course-averaged PTV for the two ART strategies relative the non-adaptive PTV were calculated. Both Clin-ART and DVF-based ART considerably reduced the course-averaged PTV, compared to non-adaptive RT. The VR for DVF-based ART was lower than for Clin-ART (0.65 vs. 0.73; p<0.01). DVF-based ART for bladder irradiation has a considerable normal tissue sparing potential surpassing our already highly conformal clinically applied ART strategy. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

VERA 3.5 Installation Guide

Energy Technology Data Exchange (ETDEWEB)

Bartlett, Roscoe A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Baird, Mark L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Berrill, Mark A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Kulesza, Joel A. [Univ. of Michigan, Ann Arbor, MI (United States); Mervin, Brenden T. [Electric Power Research Inst. (EPRI), Charlotte, NC (United States)

2016-08-16

This guide describes the structure and setup of the standard VERA development environment (VERA Dev Env) and standard VERA Third Party Libraries (TPLs) that need to be in place before installing many of the VERA simulation components. It describes everything from the initial setup on a new machine to the final build, testing, and installation of VERA components. The goal of this document is to describe how to create the directories and contents outlined in Standard VERA Dev Env Directory Structure and then obtain the remaining VERA source and build, test, and install any of the necessary VERA components on a given system. This document describes the process both for a development version of VERA and for a released tarball of the VERA sources.

VERA 3.5 Installation Guide

International Nuclear Information System (INIS)

Bartlett, Roscoe A.; Baird, Mark L.; Berrill, Mark A.; Kulesza, Joel A.; Mervin, Brenden T.

2016-01-01

This guide describes the structure and setup of the standard VERA development environment (VERA Dev Env) and standard VERA Third Party Libraries (TPLs) that need to be in place before installing many of the VERA simulation components. It describes everything from the initial setup on a new machine to the final build, testing, and installation of VERA components. The goal of this document is to describe how to create the directories and contents outlined in Standard VERA Dev Env Directory Structure and then obtain the remaining VERA source and build, test, and install any of the necessary VERA components on a given system. This document describes the process both for a development version of VERA and for a released tarball of the VERA sources.

Decreasing candidaemia rate in abdominal surgery patients after introduction of fluconazole prophylaxis*

DEFF Research Database (Denmark)

Holzknecht, B J; Thorup, J; Arendrup, M C

2011-01-01

Clin Microbiol Infect ABSTRACT: Although abdominal surgery is an established risk factor for invasive candidiasis, the precise role of antifungal prophylaxis in these patients is not agreed upon. In 2007, fluconazole was added to the prophylactic antibiotic treatment for patients with gastrointes......Clin Microbiol Infect ABSTRACT: Although abdominal surgery is an established risk factor for invasive candidiasis, the precise role of antifungal prophylaxis in these patients is not agreed upon. In 2007, fluconazole was added to the prophylactic antibiotic treatment for patients...

Evaluation of Human Epidermal Growth Factor Receptor 2 (HER2) Gene Status in Human Breast Cancer Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Specimens by Fluorescence In Situ Hybridization (FISH).

Science.gov (United States)

Hwang, Harry C; Gown, Allen M

2016-01-01

Current standard of care requires that HER2 gene testing be performed on all newly diagnosed invasive breast cancers in order to determine eligibility for anti-HER2 antibody therapy and should be performed in accordance with current ASCO-CAP guidelines (Hammond et al., J Clin Oncol 29(15):e458, 2011; Wolff et al., J Clin Oncol 31(31):3997-4013, 2013). Here we describe a HER2 FISH methodology to evaluate HER2 gene status in FFPE breast tumor specimens.

Recovery of indium from In2O3 and liquid crystal display powder via a chloride volatilization process using polyvinyl chloride

International Nuclear Information System (INIS)

Park, Kye-Sung; Sato, Wakao; Grause, Guido; Kameda, Tomohito; Yoshioka, Toshiaki

2009-01-01

Indium (In) was recovered from indium oxide (In 2 O 3 ) and liquid crystal display (LCD) powder via a chloride volatilization process using polyvinyl chloride (PVC) as the chlorination agent. The recovery of In from In 2 O 3 increased with an increasing molar Cl/In ratio in N 2 and air atmospheres. The degree of In recovery at a Cl/In molar ratio of 11 and a temperature of 350 o C was 98.7% and 96.6%, for N 2 and air, respectively. The In recovery also increased notably with increasing temperature in N 2 atmosphere. In both atmospheres, the In recovery increased with an increasing degradation temperature of PVC. However, the In recovery from LCD powder was lower than that from In 2 O 3 . For LCD powder, the degree of In recovery at a Cl/In molar ratio of 11 and a temperature of 350 o C was 66.7% and 54.1%, for N 2 and air, respectively.

Internet-Pranger auf Verdacht: Zur Bedeutung der Unschuldsvermutung für die Information der Öffentlichkeit über lebensmittelrechtliche Verstöße nach § 40 Abs. 1a Nr. 2 LFGB / Christoph Dannecker

Index Scriptorium Estoniae

Dannecker, Christoph

2013-01-01

Avalikkuse teavitamisest toiduainetega seotud seaduserikkumistest toiduaineteseaduse (Lebensmittel-, Bedarfsgegenstände- und Futtermittelgesetzbuch) § 40 lõige 1a tähenduses, mis sätestab, et avalikkust teavitab pädev asutus

Efficient Strategy to Generate a Vectored Duck Enteritis Virus Delivering Envelope of Duck Tembusu Virus

Directory of Open Access Journals (Sweden)

Zhong Zou

2014-06-01

Full Text Available Duck Tembusu virus (DTMUV is a recently emerging pathogenic flavivirus that has resulted in a huge economic loss in the duck industry. However, no vaccine is currently available to control this pathogen. Consequently, a practical strategy to construct a vaccine against this pathogen should be determined. In this study, duck enteritis virus (DEV was examined as a candidate vaccine vector to deliver the envelope (E of DTMUV. A modified mini-F vector was inserted into the SORF3 and US2 gene junctions of the attenuated DEV vaccine strain C-KCE genome to generate an infectious bacterial artificial chromosome (BAC of C-KCE (vBAC-C-KCE. The envelope (E gene of DTMUV was inserted into the C-KCE genome through the mating-assisted genetically integrated cloning (MAGIC strategy, resulting in the recombinant vector, pBAC-C-KCE-E. A bivalent vaccine C-KCE-E was generated by eliminating the BAC backbone. Immunofluorescence and western blot analysis results indicated that the E proteins were vigorously expressed in C-KCE-E-infected chicken embryo fibroblasts (CEFs. Duck experiments demonstrated that the insertion of the E gene did not alter the protective efficacy of C-KCE. Moreover, C-KCE-E-immunized ducks induced neutralization antibodies against DTMUV. These results demonstrated, for the first time, that recombinant C-KCE-E can serve as a potential bivalent vaccine against DEV and DTMUV.

The Application of NHEJ-CRISPR/Cas9 and Cre-Lox System in the Generation of Bivalent Duck Enteritis Virus Vaccine against Avian Influenza Virus

Directory of Open Access Journals (Sweden)

Pengxiang Chang

2018-02-01

Full Text Available Duck-targeted vaccines to protect against avian influenza are critically needed to aid in influenza disease control efforts in regions where ducks are endemic for highly pathogenic avian influenza (HPAI. Duck enteritis virus (DEV is a promising candidate viral vector for development of vaccines targeting ducks, owing to its large genome and narrow host range. The clustered regularly interspaced palindromic repeats (CRISPR/Cas9 system is a versatile gene-editing tool that has proven beneficial for gene modification and construction of recombinant DNA viral vectored vaccines. Currently, there are two commonly used methods for gene insertion: non-homologous end-joining (NHEJ and homology-directed repair (HDR. Owing to its advantages in efficiency and independence from molecular requirements of the homologous arms, we utilized NHEJ-dependent CRISPR/Cas9 to insert the influenza hemagglutinin (HA antigen expression cassette into the DEV genome. The insert was initially tagged with reporter green fluorescence protein (GFP, and a Cre-Lox system was later used to remove the GFP gene insert. Furthermore, a universal donor plasmid system was established by introducing double bait sequences that were independent of the viral genome. In summary, we provide proof of principle for generating recombinant DEV viral vectored vaccines against the influenza virus using an integrated NHEJ-CRISPR/Cas9 and Cre-Lox system.

Effects of concentric vs eccentric loading on cardiovascular ...

African Journals Online (AJOL)

Effects of concentric vs eccentric loading on cardiovascular variables and ECG. Madan Bhavna1*, Sarika, Sandhu J.S1. 1. Department of Sports Medicine and Physiotherapy Guru Nanak Dev University; ..... psychological and performance.

National Weather Service: Watch, Warning, Advisory Display

Science.gov (United States)

weather.gov Site Map News Organization Search for: SPC NCEP All NOAA Search by city or zip ... Fire Wx Outlooks RSS Feeds E-Mail Alerts Weather Information Storm Reports Storm Reports Dev. NWS Hazards ...

AUTHOR INDEX

Indian Academy of Sciences (India)

a granitic terrain of southern India using factor analysis and GIS. 1059. Radhakrishna M see Dev Sheena V .... Landslide susceptibility analysis using Probabilistic. Certainty Factor ... index via entropy-difference analysis. 687. Yidana Sandow ...

Tomato leaves methanol extract possesses anti- inflammatory ...

African Journals Online (AJOL)

GREGORY

2011-12-16

Dec 16, 2011 ... demonstrated, the anti-inflammatory effect of tomato leaves and its associated molecular mechanisms have not yet .... dissolved in 10% of culture-grade dimethylsulfoxide (DMSO; Sigma-. Aldrich .... In Vitro Cell. Dev. Biol.

Geospatial approach in mapping soil erodibility using CartoDEM – A ...

Indian Academy of Sciences (India)

unscientific management practices followed in the hilly regions. .... country. In the absence of large scale or detail map, researcher use the small scale of soil map prepared ..... tural development. .... mapping: An introductory perspective; Dev.

NATO Pallet with Javelin Missiles, MIL-STD-1660 Tests

National Research Council Canada - National Science Library

2004-01-01

The U.S. Army Defense Ammunition Center (DAC), Validation Engineering Division (SJMAC-DEV) conducted tests in accordance with MIL-STD-1660, "Design Criteria for Ammunition Unit Loads" on the NATO pallet with Javelin missiles...

The Empire Strikes Back

DEFF Research Database (Denmark)

Babb, Jeffry S.; Nørbjerg, Jacob; Yates, David J.

Agile methods have co-evolved with the onset of rapid change andturbidity in software and systems development and the methodologies andprocess models designed to guide them. Conceived from the lessons of practice,Agile methods brought a balanced perspective between the intensions of thestakeholder......, the management function, and developers. As an evolutionaryprogression, trends towards rapid continuous delivery have witnessed theadvent of DevOps where advances in tooling, technologies, and theenvironment of both development and consumption exert a new dynamic intothe Agile oeuvre. We investigate...... the progression from Agile to DevOps from aCritical Social Theoretic perspective to examine a paradox in agility – whatdoes an always-on conceptualization of production forestall and impinge uponthe processes of reflection and renewal that are also endemic to Agile methods?This paper is offered as a catalyst...

ORIGINAL ARTICLES Ethical and legal controversies in cloning for ...

African Journals Online (AJOL)

reproductive cloning, and that promises made too early could. Commitment ... one hand, the medical profession and the public grapple with the promise ..... Austin TW, Lagasse E. Hepatic regeneration from hematopoietic stem cells. Mech Dev ...

Genetics Home Reference: Partington syndrome

Science.gov (United States)

... Demeer B, Poirier K, Biancalana V, Pinoit JM, Julia S, Chelly J, Devys D, Mandel JL. ARX polyalanine ... The phenotypic spectrum of ARX mutations. Dev Med Child Neurol. 2005 Feb;47(2):133-7. Review. ...

Calibration of controlling input models for pavement management system.

Science.gov (United States)

2013-07-01

The Oklahoma Department of Transportation (ODOT) is currently using the Deighton Total Infrastructure Management System (dTIMS) software for pavement management. This system is based on several input models which are computational backbones to dev...

Genetics Home Reference: Weissenbacher-Zweymüller syndrome

Science.gov (United States)

... Dev Med Child Neurol. 1991 Dec;33(12):1104-9. Citation on PubMed Harel T, Rabinowitz R, ... professional . About Selection Criteria for Links Data Files & API Site Map Subscribe Customer Support USA.gov Copyright ...

Assessment of alcohol advertising practices in Ethiopia

African Journals Online (AJOL)

admin

serious social harms including violence, child neglect and abuse, and absenteeism from .... Sports Ministry (MYS), two higher learning institutions;. Addis Ababa .... entertainment industry: “Local movies use bar-scenes in. Ethiop. J. Health Dev ...

CCR 20th Anniversary Commentary: The Development of Breast Cancer Molecular Subtyping.

Science.gov (United States)

Nielsen, Torsten O; Perou, Charles M

2015-04-15

In the August 15, 2004, issue of Clinical Cancer Research, Nielsen and colleagues demonstrated how a cancer subtype identified by gene expression profiling could be validated using a widely accessible technology (immunohistochemistry). This opened the door to large-scale studies of archival cohorts and clinical trials, which allowed detailed clinical understanding of a new genomic discovery. Clin Cancer Res; 21(8); 1779-81. ©2015 AACR. See related article by Nielsen et al., Clin Cancer Res 2004;10(16) Aug 15, 2004;5367-74. ©2015 American Association for Cancer Research.

Effect of saline irrigation water on yield and yield components of rice ...

African Journals Online (AJOL)

vaio

2013-05-29

May 29, 2013 ... levels at different growth stages of rice on yield and its components. Treatments included ... Therefore, irrigation with saline water at the early growth stages has more negative effect on ...... diversification. Land Degrad. Dev.

Load and resistance factor design of bridge foundations accounting for pile group-soil interaction.

Science.gov (United States)

2015-11-01

Pile group foundations are used in most foundation solutions for transportation structures. Rigorous and reliable pile design methods are : required to produce designs whose level of safety (probability of failure) is known. By utilizing recently dev...

Southern African Journal of Anaesthesia and Analgesia - Vol 18, No ...

African Journals Online (AJOL)

Intrathecal fentanyl with 0.5% bupivacaine heavy in chronic opium abusers · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. S Gupta, K Dev, S Katyal, S Kathuria ...

Toxcast and the Use of Human Relevant In Vitro Exposures: Incorporating High-Throughput Exposure and Toxicity Testing Data for 21st Century Risk Assessments (British Toxicological Society Annual Congress)

Science.gov (United States)

The path for incorporating new approach methods and technologies into quantitative chemical risk assessment poses a diverse set of scientific challenges. These challenges include sufficient coverage of toxicological mechanisms to meaningfully interpret negative test results, dev...

Piraatlus Guinea lahes ja Nigeerias / Eero Tepp

Index Scriptorium Estoniae

Tepp, Eero

2013-01-01

Guinea lahes lokkava piraatluse põhjused ja tegurid, mis seda soodustavad: seaduselüngad, looduslikud tingimused, ebapädev korrakaitse, poliitiline olustik, kultuuriline vastuvõetavus, majanduslik tasuvus. Sõjalised ja mittesõjalised meetmetest, mida rakendatakse piraatlusevastases võitluses

Projectile, 155MM, XM982, Excalibur, Packed One (1) per PA179 Container, Unitized Up to Three (3) per 40 in. x 48 in. Wooden Pallet, MIL-STD-1660 Tests

National Research Council Canada - National Science Library

Dugan, Jeffery L

2007-01-01

The U.S. Army Defense Ammunition Center (DAC), Validation Engineering Division (SJMAC-DEV), conducted tests in accordance with MIL-STD-1660, "Design Criteria for Ammunition Unit Loads" on the XM982 155MM Excalibur Projectile packed one...

Should they stay or should they go now? Exploring the impact of team familiarity on interprofessional team training outcomes.

Science.gov (United States)

Joshi, Kavita; Hernandez, Jessica; Martinez, Joseph; AbdelFattah, Kareem; Gardner, Aimee K

2018-02-01

Although simulation is an effective method for enhancing team competencies, it is unclear how team familiarity impacts this process. We examined how team familiarity impacted team competencies. Trainees were assigned to stable or dynamic teams to participate in three simulated cases. Situation awareness (SA) data was collected through in-scenario freezes. The recorded performances were assessed for clinical effectiveness (ClinEff) and teamwork. All data are reported on a 1-100% (100% = perfect performance) scale. Forty-six trainees (23 General Surgery; 23 Emergency Medicine) were randomized by specialty into stable (N = 8) or dynamic (N = 7) groups. Overall changes from Sim 1 to Sim3 were 12.2% (p teams reflecting improvements in ClinEff (15.2%; p team ClinEff improvement (8.7%) was not significant. Both groups demonstrated improvements in teamwork (stable = 9%, p Teams who continued to work together demonstrated increased improvements in clinical effectiveness and teamwork, while dynamic teams only demonstrated improvements in teamwork. Copyright © 2017 Elsevier Inc. All rights reserved.

Démarches environnementales volontaires, conflit d’usage et proximité

Directory of Open Access Journals (Sweden)

Marie-Claude Bélis-Bergouignan

2010-11-01

Full Text Available L’article propose une analyse en termes de proximité géographique et organisée de la contribution des Démarches Environnementales Volontaires (DEV à la résolution du conflit d’usage diffus sur l’eau dans la viticulture et l’arboriculture fruitière. Dans une première partie, les DEV seront présentées comme une réponse spécifique des producteurs à ce type de conflit, la seconde partie se concentrant sur une lecture des DEV en termes de proximité. Une enquête réalisée auprès des producteurs inscrits en agriculture raisonnée ou biologique permet de montrer que la proximité organisée ne peut être porteuse à elle seule de solutions aux divergences d’intérêts entre acteurs.This paper analyses, terms of geographical and organized proximity, the contribution of Voluntary Environmental Approaches (VEA to the resolution of diffuse conflicting water uses in vine growing and fruit-bearing arboriculture. In a first part, we show that VEAs are a specific producer’s response to this kind of conflicts, the second part being centred on an analysis of VEAs in terms of proximity. An investigation towards producers engaged in integrated or organic farming shows that organized proximity alone is not able to bear solutions to divergences of interests between actors.

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Indian Academy of Sciences (India)

SEARCHU

The ability of E. tarda to adhere to and penetrate epithelial cells has been reported by several .... between the kinetic change of apoptosis in lymphoid organs and the ..... with strain differences in innate disease resistance; Dev. Comp. Immunol.

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African Journals Online (AJOL)

Afr. J. Food Agric. Nutr. Dev. 2017; 17(3): 12413-12426 ... the needs of the population. Key words: Food security, erosion, fallow, fertilizer, floods, landslide, granary, crops ... access to markets), the higher the incidence of malnutrition. Therefore ...

Journal of Agricultural Extension Vol.17 (2) December, 2013 ISSN ...

African Journals Online (AJOL)

ONIKOYI

The inefficiency of extension service in passing information to farmers is extremely difficult due to the ... It is hoped that information and communication technologies (ICTs) will provide both “new and unique ..... Revolution?”InfoDev Working ...

Injuries and Illnesses of Vietnam War POWs Revisited. 5. Combined Service Group Risk Factors

Science.gov (United States)

2017-11-08

27.34 23.16 30.09 Std Dev 57.78 48.97 38.48 47.21 Age TOC Mean 30.01 24.53 31.01 29.84 Std Dev 5.45 5.20 5.66 5.93 CapMedPrb Mean 10.40 13.66 7.12 9.03...Wallis H 28.820 2 < 0.001 ANOVA F 12.415 2, 563 < 0.001 Welch F 9.635 2, 177.559 < 0.001 Age TOC Kruskal-Wallis H 79.164 2 < 0.001 ANOVA F 42.690 2, 563...HSD < 0.001 0.016 0.756 Games-Howell < 0.001 0.038 0.764 Age TOC Mann-Whitney U 0.176 < 0.001 < 0.001 Tukey HSD 0.141 < 0.001 < 0.001 Games-Howell 0.139

Erythema-directed digital photography for the enhanced evaluation of topical treatments for acne vulgaris.

Science.gov (United States)

Micali, G; Dall'Oglio, F; Tedeschi, A; Lacarrubba, F

2018-01-31

Erythema-directed digital photography is a novel method for evaluating the efficacy and tolerability of topical acne treatments. Here, we describe three case reports in which erythema-directed digital photography was used to evaluate acne before and after up to 12 weeks of treatment with clindamycin 1%/tretinoin 0.025% (Clin-RA). Erythema-directed digital photography was used to evaluate acne in three patients with mild-to-moderate facial acne, two of whom had refused to continue previous topical acne treatment (benzoyl peroxide 5% and clindamycin 1%/benzoyl peroxide 5%) due to persistent irritation. Acne lesions and erythema were evaluated using standard clinical photography and erythema-directed digital photography (VISIA-CR ™ system) before and after 8-12 weeks of treatment with Clin-RA. Erythema-directed digital photography revealed background erythema from previous topical acne treatments that was not evident from standard clinical photographs and allowed a better visualization of both inflammatory and non-inflammatory lesions. In all patients, there was a clear improvement in background erythema and a reduction in acne lesions following treatment with Clin-RA. This study has demonstrated for the first time that erythema-directed digital photography can enhance the evaluation of the efficacy and tolerability of topical acne treatments. These cases show that Clin-RA was associated with improved efficacy and tolerability vs previous treatments with topical monotherapy (benzoyl peroxide 5%) or a topical fixed-dose combination (clindamycin 1%/benzoyl peroxide 5%). © 2018 The Authors. Skin Research and Technology Published by John Wiley & Sons Ltd.

Agro. No. 2.cdr Corrected

African Journals Online (AJOL)

TOSHIBA

Mean. Std.Dev. Minimum. Maximum. Output in (kg). 2206.4. 933.47. 650. 5000. Pond size (cm2). 807.8 ... Table 3: Stochastic frontier estimates for catfish production in Ijumu LGA. Variables. Parameter ... Variance Parameter. Sigma square δ2.

Influence of plant growth regulators on somatic embryos induction ...

African Journals Online (AJOL)

TANOH

2013-04-17

Theobroma cacao L.) using Thidiazuron. In vitro Cell Dev. Biol. 34:293-299. Michaux-Ferrière N, Carron MP (1989). Histology of early somatic embryogenesis in Hevea brasiliensis. The importance of timing of subculturing. Plant Cell Tiss ...

In vitro assessment of 3 dentifrices containing fluoride in preventing demineralization of overdenture abutments and root surfaces.

Science.gov (United States)

Goettsche, Zachary S; Ettinger, Ronald L; Wefel, James S; Hogan, Mary M; Harless, Jeffery D; Qian, Fang

2014-11-01

Caries development under overdentures has been a continuing problem and requires the daily use of fluoride to prevent demineralization. The purpose of this in vitro study was to compare the effectiveness of dentifrices containing tricalcium phosphate or calcium phosphosilicate in combination with fluoride to prevent the demineralization of overdenture abutments and root surfaces. A total of 56 caries-free extracted teeth were prepared as overdenture abutments. The teeth were painted with acid-resistant varnish, leaving one 1×4-mm window on occlusal and root surfaces. The teeth were randomly divided into 4 groups: a control group treated with distilled/deionized water only, a group treated with ClinPro 5000, a group treated with ReNew, and a group treated with Prevident 5000 gel. Each tooth was subjected to a demineralizing/remineralizing cycling protocol for 12 days with the appropriate treatment products. The teeth were sectioned longitudinally through both windows. Photomicrographs were made of 3 representative sections from each tooth. A representative section was defined as one that included both windows and was cut from the part of the tooth that had the flattest surface to reduce the edge effect. The depths of the lesions were measured on representative sections from each group. A 1-way MANOVA and a 1-way ANOVA with the post hoc Tukey-Kramer test were used to evaluate the treatment effects on the criterion variables (α=.05). The total lesion depths of the control teeth on the occlusal surface were not statistically significantly deeper than for the 3 dentifrices (P=.7705). However, all 3 dentifrices had narrower cavitation depths than the control (mean cavitation band depth, 43.59 [ReNew] versus 37.99 [Prevident 5000 gel] versus 36.70 [ClinPro 5000] versus 246.86 [control]) (Pteeth treated with Prevident 5000 gel had the shallowest total lesion depth and were statistically significantly different from those treated with ReNew and Clin

Cassandra high availability

CERN Document Server

Strickland, Robbie

2014-01-01

If you are a developer or DevOps engineer who understands the basics of Cassandra and are ready to take your knowledge to the next level, then this book is for you. An understanding of the essentials of Cassandra is needed.

INTERIM REPORT, DEVELOP A SAMPLING STRATEGY: PREPARE TO IMPLEMENT A COHORT STUDY OF CHILDREN'S ENVIRONMENTAL HEALTH

Science.gov (United States)

OverviewThe goal of the National Children's Study (NCS) is to collect information on environmental andsocial factors in the lives of children, starting before birth and continuing until age 21, to informresearchers about their effects on the health and dev...

48 CFR 5152.245-9001 - Government property for installation support services (cost-reimbursement contracts).

Science.gov (United States)

2010-10-01

... installation support services (cost-reimbursement contracts). 5152.245-9001 Section 5152.245-9001 Federal... CONTRACT CLAUSES 5152.245-9001 Government property for installation support services (cost-reimbursement... Installation Support Services (Cost-Reimbursement Contracts) (OCT 1989) (DEV) (a) Government-furnished property...

78 FR 15683 - Certain Preserved Mushrooms From the People's Republic of China: Preliminary Results of...

Science.gov (United States)

2013-03-12

... National Cereals, Oils & Foodstuffs Import & Export Corp. (China National), (2) China Processed Food Import...) Co., Ltd. (Primera Harvest), (10) Shandong Fengyu Edible Fungus Corporation Ltd. (Shandong Fengyu... Hengyong Industrial & Commercial Dev., Ltd. (Guangxi Hengyong), (2) Zhangzhou Tongfa Foods Industry Co...

Environmental history impacts gene expression during diapause development in the alfalfa leafcutting bee, Megachile rotundata

Science.gov (United States)

Our understanding of the mechanisms controlling insect diapause has increased dramatically with the introduction of global gene expression techniques, such as RNAseq. However, little attention has been given to how ecologically relevant field conditions may affect gene expression during diapause dev...

EVALUATION OF THE CARBON FOOTPRINT OF INNOVATIVE WATER MAIN REHABILITATION TECHNOLOGIES VS. OPEN CUT METHODS

Science.gov (United States)

A major benefit of trenchless rehabilitation technologies touted by many practitioners when comparing their products with tradition open cut construction methods is lower carbon dioxide (CO2) emissions. In an attempt to verify these claims, multiple tools have been dev...

Cooperation between information system development and operations: a literature review

NARCIS (Netherlands)

Erich, Floris; Amrit, Chintan Amrit; Daneva, Maia; Torchiano, M.

2014-01-01

Software development can profit from improvements in the deployment and maintenance phases. DevOps improves these phases through a collection of principles and practices, centered around close collaboration between Development and Operations personnel. Both sides have paid little attention to issues

Investigation on Mandarin Broadcast News Speech Recognition

National Research Council Canada - National Science Library

Hwang, Mei-Yuh; Lei, Xin; Wang, Wen; Shinozaki, Takahiro

2006-01-01

.... Their final system achieved a 6.0% character error rate (CER) on dev04 and a 16.0% CER on eval04 with simpler acoustic models, less training data, and simpler decoding architecture compared with other state-of-the-art systems...

Business process maturity assessment : state of the art and key characteristics

NARCIS (Netherlands)

Tarhan, A.; Turetken, O.; Ilisu, F.

2015-01-01

Business processes are basic enablers in sustaining an organization's existence in delivering high-quality products and services. A maturity model is an instrument to assess and continually improve business processes. For example, Capability Maturity Model Integration for Development (CMMI-Dev) in

GENERAL OPHTHALMOLOGY

African Journals Online (AJOL)

2016-11-04

Nov 4, 2016 ... Nelson-Immu JC, Mowatt L, Walters C.A. Patterns of ocular trauma presenting to the ... 11 hospital, Addis Ababa. Ethiop J Health Dev 2001;15:131-7. 12. ... injuries in Irrua Specialist Teaching Hospital, Irrua, Edo State Nigeria.

An innovative approach to investigate the dynamics of the cerebrospinal fluid in the prepontine cistern: A feasibility study using spatial saturation-prepared cine PC-MRI

International Nuclear Information System (INIS)

Rüegger, Christoph M.; Makki, Malek I.; Capel, Cyrille; Gondry-Jouet, Catherine; Baledent, Olivier

2014-01-01

•An innovative sat-pulse based cine PC-MRI to investigate complex CSF dynamic.•Compared to conventional sequence and validated in the PPC of hydrocephalus patients.•No compromise neither on temporal nor on spatial resolution.•Compared to conventional exam: the PPC has same area but lower flow stroke volume.•It contributes to a better follow-up of patients with altered CSF circulation. An innovative sat-pulse based cine PC-MRI to investigate complex CSF dynamic. Compared to conventional sequence and validated in the PPC of hydrocephalus patients. No compromise neither on temporal nor on spatial resolution. Compared to conventional exam: the PPC has same area but lower flow stroke volume. It contributes to a better follow-up of patients with altered CSF circulation. Accurate measurements of the cerebrospinal fluid that flows through the prepontine cistern (PPC) are challenging due to artefacts originating from basilar artery blood flow. We aim to accurately quantify cerebrospinal fluid (CSF) flow and stroke volume in the PPC, which is essential before endoscopic third ventriculostomy. We developed a new PC-MRI sequence prepared with Hadamard saturation bands to accurately quantify CSF flow in the PPC by suppressing the blood signal in the surrounding vessels. In total, 28 adult hydrocephalic patients (age 59 ± 20 years) were scanned using conventional PC-MRI and our developed sequence. CSF was separately extracted from the PPC and the foramen of Magendie, and flow (min and max) and stroke volume were quantified. Our modifications result in a complete deletion of signal from flowing blood, resulting in significantly reduced CSF stroke volume (Conv = 446 ± 113 mm 3 , Dev = 390 ± 119 mm 3 , p = 0.006) and flow, both minimum (Conv = −1630 ± 486 mm 3 /s, Dev = −1430 ± 406 mm 3 /s, p = 0.005) and maximum (Conv = 2384 ± 657 mm 3 /s, Dev = 1971 ± 62 mm 3 /s, p = 0.002) compared with the conventional sequence, whereas no change in the area of interest was

Wang et al., Afr J Tradit Complement Altern Med. (2015) 12(5):118 ...

African Journals Online (AJOL)

Proff.Adewunmi

Using randomized controlled clinical research method, random number table was generated by statistics software. 30 healthy volunteers ..... Observation on activating effectiveness of acupuncture at acupoints and non-acupoints on different brain ... children with ADHD revealed by resting-state functional MRI. Brain Dev ...

Improving component interoperability and reusability with the java connection framework (JCF): overview and application to the ages-w environmental model

Science.gov (United States)

Environmental modeling framework (EMF) design goals are multi-dimensional and often include many aspects of general software framework development. Many functional capabilities offered by current EMFs are closely related to interoperability and reuse aspects. For example, an EMF needs to support dev...

Phenazine-1-carboxylic acid influences biofilm development and turnover of rhizobacterial biomass in a soil moisture-dependent manner

Science.gov (United States)

Rhizobacterial biofilm development influences terrestrial carbon and nitrogen cycles with ramifications for crop and soil health. Phenazine-1-carboxylic acid (PCA) is a redox-active metabolite produced by rhizobacteria in dryland wheat fields of Washington and Oregon, USA. PCA promotes biofilm dev...

Durability of certain configurations for providing skid resistance on concrete pavements.

Science.gov (United States)

1974-01-01

The main objective of this study was to establish the factors that influence the durability of the surface configurations that are used or can be used to provide high and long lasting skid resistance for portland cement concrete pavements. In the dev...

Cost-Effectiveness of Aflatoxin Control Methods: Economic Incentives

Science.gov (United States)

Multiple sectors in U.S. crop industries – growers, elevators, handlers/shellers, processors, distributors, and consumers – are affected by aflatoxin contamination of commodities, and have the potential to control it. Aflatoxin control methods at both preharvest and postharvest levels have been dev...

Hospitality Branding in the Age of the Millennial

Directory of Open Access Journals (Sweden)

Chekitan S. Dev

2016-10-01

Full Text Available The past decade has seen exponential growth in hospitality brands making for an often confounding proliferation of options for travelers. Adamson and Dev suggest how brands can make their message clear among the generation with the most buying power .

Ergonomics SA - Vol 21, No 1 (2009)

African Journals Online (AJOL)

Ergonomics study on Musculoskeletal Disorders among female agricultural workers of West Bengal, India · EMAIL FULL TEXT EMAIL FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. S Gangopadhyay, B Das, T Das, G Ghoshal, T Ghosh, T Ara, S Dev, 11-22 ...

Running R Statistical Computing Environment Software on the Peregrine

Science.gov (United States)

") print(p) dev.off() Parallel Programming in R Programming in R on Peregrine has two distinct parallel processing. R code, like many programming languages, is typically written and executed serially highlight interesting packages, problems, and share experiences related to R programming. Contact Daniel

On the Integration of Automatic Deployment into the ABS Modeling Language

NARCIS (Netherlands)

C.P.T. de Gouw (Stijn); M. Lienhardt; J. Mauro (Jacopo); B. Nobakht (Behrooz); G. Zavattaro (Gianluigi); S. Dustdar; F. Leymann; M. Villari

2015-01-01

htmlabstractIn modern software systems, deployment is an integral and critical part of application development (see, e.g., the DevOps approach to software development). Nevertheless, deployment is usually overlooked at the modeling level, thus losing the possibility to perform deployment conscious

CERN Computing Colloquia Spring Series: IT Security - A High-Performance Pattern Matching Engine for Intrusion Detection

CERN Multimedia

CERN. Geneva

2006-01-01

The flexible and modular design of the engine allows a broad spectrum of applications, ranging from high-end enterprise level network devices that need to match hundreds of thousands of patterns at speeds of tens of gigabits per second, to low-end dev...

Regenerative Medicine for Battlefield Injuries

Science.gov (United States)

2014-10-01

Manual of Experimental Embryology . University of Chicago Press, Chicago. Harris JS, Bemenderfer TB, Wessel AR, Kacena MA (2013) A review of mouse...proliferation and apoptosis . Dev Dynam 219:237-247. Patterson TE, Kumagal K, Griffith L, Muschler GF (2008) Cellular strategies for enhancement

The role of elevated central-peripheral temperature difference in early detection of late-onset sepsis in preterm infants.

Science.gov (United States)

Ussat, M; Vogtmann, C; Gebauer, C; Pulzer, F; Thome, U; Knüpfer, M

2015-12-01

The study investigated the association between clinical symptoms and late-onset sepsis (LOS) in preterm infants with the aim of identifying a non-invasive tool for the early detection of LOS. This was a prospective study of 83 episodes of suspected LOS in 67 preterm infants. At the time LOS was suspected, we recorded a standardized set of clinical symptoms. A diagnosis of "clinical LOS" (Clin-LOS), "culture-proven LOS" (Prov-LOS) or "LOS not present" (No-LOS) was made on the basis of C-reactive protein (CrP) and blood culture results where Clin-LOS was defined as CrP>10mg/l, Prov-LOS was defined as CrP>10mg/l AND positive blood cultures, or it was established that there was no sepsis present (No-LOS). We examined univariable associations between clinical signs and LOS using odds ratio (OR) analysis and then adjusted the odds ratio (adOR) through binary regression analysis. Clin-LOS was diagnosed in 20/83 episodes, 19 cases were found to have Prov-LOS. Clinical signs which had a significant association with Clin-LOS were capillary refill time >2s (OR 2.9) and decreased responsiveness (OR 5.2), whereas there was a negative association between gastric residuals and LOS (OR 0.35). However, the most marked association was found for a greater central-peripheral temperature difference (cpTD) >2°C (OR 9). In Prov-LOS an increased heart rate (OR 3.1), prolonged capillary refill time (OR 3.3) and again an increased cpTD (OR 16) had a significant association with LOS, whereas gastric residuals were negatively associated (OR 0.29). Regression analysis showed that cpTD was the most striking clinical sign associated with both Clin- (adOR 6.3) and Prov-LOS (adOR 10.5). Prolonged capillary refill time and - more impressive - elevated cpTD were the most useful clinical symptoms for detection of LOS in preterm infants. We especially suggest using cpTD as a predictor of LOS. It is a cheap, non-invasive and readily available tool for daily routines. Copyright © 2015. Published by

The Clinician-Educator Pathway in Radiology: An Analysis of Institutional Promotion Criteria.

Science.gov (United States)

Jhala, Khushboo; Kim, Jisoo; Chetlen, Alison; Nickerson, Joshua P; Lewis, Petra J

2017-12-01

To provide radiology departmental promotional committees and vice chairs of education with a more global perspective on the types of academic activity valued by institutions to aid in their faculty mentoring and standardizing of the Clinician-Educator (ClinEd) pathway. Ninety-two research schools were ranked into three tiers. Ranking was correlated with the presence of a ClinEd track. Thirty promotion documents (ten from each tier) were analyzed to identify common criteria. Differences in guidelines between tiers were assessed by the frequency distribution of criteria. Tier 1 had a significantly greater proportion of schools with a ClinEd track than tier 2 (73% versus 44%, p < 0.05). Thirty-nine criteria were identified and organized into four categories teaching (13), scholarship (12), service/clinical excellence (7), and research (7). The top five included meeting presentations, trainee evaluations, leadership in committees, development of teaching methodologies and materials, and publication of book chapters. First and second tier schools were most similar in frequency distribution. The criteria for the ClinEd promotion track still vary across institutions, though many commonalities exist. A handful of innovative criteria reflect the changing structure of modern health care systems, such as incorporation of online teaching modules and quality improvement efforts. As health care changes, guidelines and incentive structures for faculty should change as well. The information gathered may provide promotion committees with a more global perspective on the types of academic activity valued by modern-day institutions to aid in the national standardization of this pathway and to assist in faculty mentoring. Copyright © 2017 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Rahvas pole alati pädev õpetama / Juhan Kivirähk

Index Scriptorium Estoniae

Kivirähk, Juhan, 1957-

2003-01-01

Ahto Lobjakase artiklist "Eestlane usaldab euroliitu NATO-st ja USA-st rohkem" 11. okt. Eesti Päevalehes, mis käsitles Eurobaromeetri uuringut. J. Kivirähki hinnangul on uuringu metoodikas küsitavusi

Transformational Leadership and Organizational Change during Agile and DevOps Initiatives

Science.gov (United States)

Mayner, Stephen W.

2017-01-01

Organizational change initiatives are more likely to fail than to succeed, especially when the change challenges corporate culture and norms. Researchers have explored factors that contribute to change failure, to include the relationship between leadership behaviors and change success. Peer reviewed studies have yet to examine these variables in…

A Cell Model to Evaluate Chemical Effects on Adult Human Cardiac Progenitor Cell Differentiation and Function

Science.gov (United States)

Adult cardiac stem cells (CSC) and progenitor cells (CPC) represent a population of cells in the heart critical for its regeneration and function over a lifetime. The impact of chemicals on adult human CSC/CPC differentiation and function is unknown. Research was conducted to dev...

Camera-based microswitch technology to monitor mouth, eyebrow, and eyelid responses of children with profound multiple disabilities

NARCIS (Netherlands)

Lancioni, G.E.; Bellini, D.; Oliva, D.; Singh, N.N.; O'Reilly, M.F.; Sigafoos, J.; Lang, R.B.; Didden, H.C.M.

2011-01-01

A camera-based microswitch technology was recently used to successfully monitor small eyelid and mouth responses of two adults with profound multiple disabilities (Lancioni et al., Res Dev Disab 31:1509-1514, 2010a). This technology, in contrast with the traditional optic microswitches used for

Authentication of food allergen quality by physicochemical and immunological methods

DEFF Research Database (Denmark)

Sancho, A I; Hoffmann-Sommergruber, K; Alessandri, S

2010-01-01

Purified allergens are required to detect cross-contamination with other allergenic foods and to understand allergen interaction with other components of the food matrix. Pure allergens are also used for the diagnosis and treatment of food allergies. For example, serological methods are being dev...

To Innovate Better, Find Divergent Thinkers

DEFF Research Database (Denmark)

Poetz, Marion; Hippel, Eric von

2015-01-01

The article discusses the practice of seeking advice and ideas from practitioners in analogous fields. It references a study on search methodologies by Marion Poetz and colleagues at the Copenhagen Business School and Zeppelin University. Poetz and colleagues used a pyramid search methodology dev...

Rozrůzněná avantgarda. Poznámky ke vztahu expresionismu a avantgardy v českém kontextu

Czech Academy of Sciences Publication Activity Database

Malá, Zuzana

2013-01-01

Roč. 61, č. 1 (2013), s. 68-85 ISSN 0009-0468 Institutional support: RVO:68378068 Keywords : Czech literature * avant-garde * expressionism * strategy * Devětsil * Literární skupina * Teige, Karel * Götz, František Subject RIV: AJ - Letters, Mass-media, Audiovision

Retrospective review of antiretroviral therapy program data in ...

African Journals Online (AJOL)

ÿþB e r n t L i n d t j ø r n

2009-12-31

Dec 31, 2009 ... Methods: Descriptive retrospective analyses of reported ART Program Data from accredited private hospitals, between May 2005 and ... retention and tracing in the accredited private hospitals in Addis Ababa City Administration. [Ethiop J Health Dev. ..... therapy in rural communities: The Lusikisiki model.

A Behavioral Treatment for Traumatic Brain Injury-Associated Visual Dysfunction Based on Adult Cortical Plasticity

Science.gov (United States)

2014-12-01

Zomet, Lev, Yehezkel, Sterkin & Levi, 2012b) and developmental object and face agnosia (Lev, Gilaie-Dotan, Gotthilf-Nezri, Yehezkel, Brooks, Perry...followed by mid-level perceptual improvements in developmental object and face agnosia . Dev Sci, Lev, M., Ludwig, K., Gilaie-Dotan, S., Voss, S

Synchronization of indirectly coupled Lorenz oscillators

Indian Academy of Sciences (India)

Synchronization of indirectly coupled Lorenz oscillators: An experimental study. Amit Sharma Manish Dev Shrimali. Synchronization, Coupled Systems and Networks Volume 77 Issue 5 November 2011 pp 881-889 ... The in-phase and anti-phase synchronization of indirectly coupled chaotic oscillators reported in Phys. Rev ...

The prevalence of intestinal helminthic infections and associated ...

African Journals Online (AJOL)

Preferred Customer

Breivika, N-9037, Tromsø, Norway; Department of Medical Laboratory Technology, Faculty of Health Sciences,. Alemaya .... quantity, time, and procedure of collection. ... J.Health Dev. 2005;19(2). Table 1: Prevalence of intestinal helminths among Babile town schoolchildren, Eastern. Ethiopia, 2001. Parasite species. Males.

Proceedings of the Workshop on Unsteady Separated Flow Held at the United States Air Force Academy on August 10-11, 1983

Science.gov (United States)

1984-05-01

file for further analysis. The procedure abcve is then repeated for each probe position. In this runner , the complete time...Calculation Methods Cur e’s original nethod has been modified to ..j" .. Kite trie jnsteady bpunddry layer dev.e1oprnent. rnis is

Experiment list: SRX879756 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available SRX879756 mm9 No description NA Liver Liver MeSH Description=The number of offspring produced at one birth... strain=C57Bl/6 x Sv/129 || dev_stage=adult || sex=female || tissue=liver || birth_date=03/25/11 || death_da

DEMONSTRATION BULLETIN: TEXACO GASIFICATION PROCESS TEXACO, INC.

Science.gov (United States)

The Texaco Gasification Process (TGP) has operated commercially for nearly 45 years on feeds such as natural gas, liquid petroleum fractions, coal, and petroleum coke. More than 45 plants are either operational or under development in the United States and abroad. Texaco has dev...

Translating material and design space

DEFF Research Database (Denmark)

Tamke, Martin; Ramsgaard Thomsen, Mette; Joseffson, Kristoffer

2009-01-01

This paper shares findings from the project DevA (Developable surfaces in Architecture), a research by design based project developed a collaboration between academic and industry partners. The project aims to investigate the use of curved sheet material in architecture using hybridised 3D...

The Learning Effects of a Multidisciplinary Professional Development Programme

NARCIS (Netherlands)

Visser, Talitha Christine; Coenders, Ferdinand G.M.; Pieters, Julius Marie; Terlouw, C.

2013-01-01

Professional development becomes relevant and effective when teachers are actively involved, collaborate, and when it is linked to teachers’ daily school practice (Hunzicker in Prof Dev Educ 37:177–179, 2011). Preparation of teachers for a curriculum implementation such as the new subject Nature,

Resonance and Transcendence of a Bodily Presence

DEFF Research Database (Denmark)

Petersen, Rikke Munck; Farsø, Mads

2018-01-01

This article elucidates how film may offer itself as ‘resonance tool’ for both representation and conception of space that can strengthen an alternative, phenomenological and haptic position of transcendence in architecture, a position from which landscapes and cities are thought, planned and dev...

Fluorescence-Based Reporter for Gauging Cyclic Di-GMP Levels in Pseudomonas aeruginosa

DEFF Research Database (Denmark)

Rybtke, Morten T.; Borlee, Bradley R.; Murakami, Keiji

2012-01-01

The increased tolerance toward the host immune system and antibiotics displayed by biofilm-forming Pseudomonas aeruginosa and other bacteria in chronic infections such as cystic fibrosis bronchopneumonia is of major concern. Targeting of biofilm formation is believed to be a key aspect in the dev...

The Empire Strikes Back

DEFF Research Database (Denmark)

Babb, Jeffry S.; Nørbjerg, Jacob; Yates, David J.

2017-01-01

, the management function, and developers. As an evolutionary progression, trends towards rapid continuous delivery have witnessed the advent of DevOps where advances in tooling, technologies, and the environment of both development and consumption exert a new dynamic into the Agile oeuvre. We investigate...

Conference on the Neurobiology of Learning and Memory (3rd)

Science.gov (United States)

1988-09-23

TREATMENT IN PARADOXICAL SLEEP I. Portell-Cortes, DEPRIVATION PLATFORMS IN RATS . Norpdo-Bernal Area do Psicobiologia Dept. de Psicologia do la Salut Univ...Ignacio Morgado-Bernal Dr. Georges Moroz Area de Psicobiologia CNS Development Psicologia do la Salud CIBA-GEIGY Corp. Univ. Autonoma do Barcelona DEV

Harnessing the soil microbiome for increased drought resistance

Science.gov (United States)

Dr. Manter is a Research Soil Scientist in the Soil Management and Sugar Beet Research Unit (SMSBRU) of the USDA-Agricultural Research Service in Fort Collins, Colorado. His research examines soil biology and plant-microbial interactions aimed at optimizing soil health. Research emphasis is on dev...

Toxcast Profiling in a Human Stem Cell Assay for Developmental Toxicity (SOT)

Science.gov (United States)

We correlated the ToxCast library in a metabolic biomarker-based in vitro assay (Stemina devTOXqP) utilizing human embryonic stem (hES) cells (H9 line). This assay identifies the concentration of a chemical that disrupts cellular metabolism in a manner indicative of teratogenic...

A New GIS-Nitrogen Trading Tool Concept to Minimize Reactive Nitrogen losses to the Environment

Science.gov (United States)

Nitrogen (N) is an essential element which is needed to maximize agricultural production and sustainability of worldwide agroecosystems. N losses to the environment are impacting water and air quality that has become an environmental concern for the future generations. It has led to the need for dev...

Friendlessness and Theory of Mind: A Prospective Longitudinal Study

NARCIS (Netherlands)

Fink, E.; Begeer, S.M.; Peterson, C.; Slaughter, V.; De Rosnay, M.

2015-01-01

Chronic friendlessness in childhood predicts adverse mental health outcomes throughout life, yet its earliest roots are poorly understood. In theory, developing a theory of mind (ToM) should help children gain mutual friends and one preschool study (Peterson and Siegal, 2002. Br J Dev Psychol, 20,

Pramana – Journal of Physics | Indian Academy of Sciences

Indian Academy of Sciences (India)

... which in fact yields a larger fixed point range than that obtained under constant mean-value parameters. Volume 77 Issue 5 November 2011 pp 881-889 Synchronization, Coupled Systems and Networks. Synchronization of indirectly coupled Lorenz oscillators: An experimental study · Amit Sharma Manish Dev Shrimali.

Sensory analysis of rainbow trout, oncorhynchus mykiss, fed enriched black soldier fly prepupae, hermetia illucens

Science.gov (United States)

A growth trial and fillet sensory analysis were conducted to examine the effects of replacing dietary fish meal with black soldier fly (BSF) prepupae, Hermetia illucens, in rainbow trout, Oncorhynchus mykiss. A practical-type trout diet was formulated to contain 45% protein; four test diets were dev...

Retrofit of Ressalat jacket platform (Persian Gulf) using friction damper device

DEFF Research Database (Denmark)

Komachi, Y.; Tabeshpour, M. R.; Golafshani, A. A.

2011-01-01

A friction damper device (FDD) is used for vibration control of an existing steel jacket platform under seismic excitation. First, the damping is presented for vibration mitigation of structures located in seismically active zones. A new method for quick design of friction or yielding damping dev...

Human Pluripotent Stem Cell-Based Assay Predicts Developmental Toxicity Potential of ToxCast Chemicals (ACT meeting)

Science.gov (United States)

Worldwide initiatives to screen for toxicity potential among the thousands of chemicals currently in use require inexpensive and high-throughput in vitro models to meet their goals. The devTOX quickPredict platform is an in vitro human pluripotent stem cell-based assay used to as...

Experiment list: SRX879757 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available SRX879757 mm9 No description NA Liver Liver MeSH Description=The number of offspring produced at one birth...rain=C57Bl/6 x Sv/129 || dev_stage=adult || sex=male || tissue=liver || birth_date=09/14/10 || death_date=08

Experiment list: SRX882974 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available SRX882974 mm9 DNase-seq DNase-Seq Liver Liver MeSH Description=The number of offspring produced at one birth...GAIIx strain=C57Bl/6 x Sv/129 || dev_stage=adult || sex=male || tissue=liver || birth_date=03/20/13 || death

Experiment list: SRX879758 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available SRX879758 mm9 No description NA Liver Liver MeSH Description=The number of offspring produced at one birth...train=C57Bl/6 x Sv/129 || dev_stage=adult || sex=male || tissue=liver || birth_date=09/06/10 || death_date=0

Genetics Home Reference: Potocki-Lupski syndrome

Science.gov (United States)

... cause the disorder. Most cases of Potocki-Lupski syndrome result from a new (de novo) chromosomal duplication and occur in people with ... or Free article on PubMed Central Treadwell-Deering DE, ... of the Potocki-Lupski syndrome (duplication 17p11.2). J Dev Behav Pediatr. 2010 ...

Multiple chromosomal gene integration for production of pharmaceutical proteins in S. cerevisiae

DEFF Research Database (Denmark)

Jensen, Malene; Mortensen, Uffe Hasbro; Gunnarsson, Nina

2014-01-01

When studying protein folding and secretion the general conception is that all cells in a population express an equal amount of protein. Recent work has shown that expression levels vary greatly in cell populations which express proteins on plasmids. Hence a yeast expression platform has been dev...

Getting started with tmux

CERN Document Server

Quinn, Victor

2014-01-01

The book is intended for software developers, DevOps engineers, and other professionals who make heavy use of the terminal in their daily workflow. Some familiarity with the terminal is useful but no prior experience with tmux or other terminal multiplexers (such as GNU Screen) is required.

Review Article eview Article

African Journals Online (AJOL)

User

2013-06-28

Jun 28, 2013 ... Recent years, foreign investment in productive agricultural land in dev ... there is an in rights of people. ... Administration, College of Business and Economics, Wollega University, ost Box No: ..... agricultural workers, rural women, and indigenous ... Southeast Asia and sub-Saharan Africa (Jama and. Pizarro ...

EDITORIAL Traditional medicine: Reawakening a “pending agendum”.

African Journals Online (AJOL)

admin

that show the workforce represented by practitioners of traditional medicine ... sector to health, wellness and people-centered health care; and ... J. Health Dev. and supervised use of traditional medicine practitioners in strengthening and expanding primary health care services. Furthermore, both the Health Policy (13) and ...

SAMJFORUM

African Journals Online (AJOL)

episodes, and Einstein, Faraday, Coleridge and Goya were among the many we might today diagnose as schizotypal. ... Martin J, Clubley E. The autism-spectrum quotient (~Q): evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians./ Autism Dev.Disord. 2001; 31: 5-17.

Development of a Prototype System for Archiving Integrative/Hybrid Structure Models of Biological Macromolecules.

Science.gov (United States)

Vallat, Brinda; Webb, Benjamin; Westbrook, John D; Sali, Andrej; Berman, Helen M

2018-04-09

Essential processes in biology are carried out by large macromolecular assemblies, whose structures are often difficult to determine by traditional methods. Increasingly, researchers combine measured data and computed information from several complementary methods to obtain "hybrid" or "integrative" structural models of macromolecules and their assemblies. These integrative/hybrid (I/H) models are not archived in the PDB because of the absence of standard data representations and processing mechanisms. Here we present the development of data standards and a prototype system for archiving I/H models. The data standards provide the definitions required for representing I/H models that span multiple spatiotemporal scales and conformational states, as well as spatial restraints derived from different experimental techniques. Based on these data definitions, we have built a prototype system called PDB-Dev, which provides the infrastructure necessary to archive I/H structural models. PDB-Dev is now accepting structures and is open to the community for new submissions. Copyright © 2018 Elsevier Ltd. All rights reserved.

Hybrid Network Simulation for the ATLAS Trigger and Data Acquisition (TDAQ) System

CERN Document Server

Bonaventura, Matias Alejandro; The ATLAS collaboration; Castro, Rodrigo Daniel; Foguelman, Daniel Jacob

2015-01-01

The poster shows the ongoing research in the ATLAS TDAQ group in collaboration with the University of Buenos Aires in the area of hybrid data network simulations. he Data Network and Processing Cluster filters data in real-time, achieving a rejection factor in the order of 40000x and has real-time latency constrains. The dataflow between the processing units (TPUs) and Readout System (ROS) presents a “TCP Incast”-type network pathology which TCP cannot handle it efficiently. A credits system is in place which limits rate of queries and reduces latency. This large computer network, and the complex dataflow has been modelled and simulated using a PowerDEVS, a DEVS-based simulator. The simulation has been validated and used to produce what-if scenarios in the real network. Network Simulation with Hybrid Flows: Speedups and accuracy, combined • For intensive network traffic, Discrete Event simulation models (packet-level granularity) soon becomes prohibitive: Too high computing demands. • Fluid Flow simul...

Metodología para implantar el Modelo Integrado de Capacidad de Madurez en grupos pequeños y emergentes

Directory of Open Access Journals (Sweden)

Hugo Arboleda

2013-04-01

Full Text Available En este artículo se presenta QualDev-Software Process Improvement (SPI, una metodología para ayudar a la gerencia de empresas o departamentos de software pequeños y emergentes a implantar el Capability Maturity Model Integration (CMMI. El objetivo de esta metodología es aumentar la competitividad de estos grupos para que ofrezcan mayor calidad en sus productos y tengan mejores indicadores de productividad. QualDev-SPI se basa en 3 principios: a pequeños pasos para el mejoramiento alineados con los proyectos de desarrollo; b procesos livianos apoyados en herramientas, y c visibilidad a corto plazo de los beneficios. La metodología incluye un modelo de mejoramiento organizacional, una matriz de grados de logro de las prácticas y un mapa de ruta que contiene una definición estandarizada de procesos y de las herramientas de apoyo que facilitan su puesta en marcha.

Metodología para implantar el Modelo Integrado de Capacidad de Madurez en grupos pequeños y emergentes

Directory of Open Access Journals (Sweden)

Hugo Arboleda

2013-01-01

Full Text Available En este artículo se presenta QualDev- Software Process Improvement (SPI, una metodología para ayudar a la gerencia de empresas o departamentos de software peque ̃ nos y emergentes a implantar el Capability Maturity Model Integration (CMMI. El objetivo de esta metodología es aumentar la competitividad de estos grupos para que ofrezcan mayor calidad en sus productos y tengan mejores indicadores de produc- tividad. QualDev-SPI se basa en 3 principios: a peque ̃ nos pasos para el mejoramiento alineados con los proyectos de desarrollo; b procesos livianos apoyados en herramientas, y c visibilidad a corto plazo de los beneficios. La metodología incluye un modelo de mejoramiento organizacional, una matriz de grados de logro de las prácticas y un mapa de ruta que contiene una definición estandarizada de procesos y de las herramientas de apoyo que facilitan su puesta en marcha.

Square biphasic pulse deep brain stimulation for essential tremor: The BiP tremor study.

Science.gov (United States)

De Jesus, Sol; Almeida, Leonardo; Shahgholi, Leili; Martinez-Ramirez, Daniel; Roper, Jaimie; Hass, Chris J; Akbar, Umer; Wagle Shukla, Aparna; Raike, Robert S; Okun, Michael S

2018-01-01

Conventional deep brain stimulation (DBS) utilizes regular, high frequency pulses to treat medication-refractory symptoms in essential tremor (ET). Modifications of DBS pulse shape to achieve improved effectiveness is a promising approach. The current study assessed the safety, tolerability and effectiveness of square biphasic pulse shaping as an alternative to conventional ET DBS. This pilot study compared biphasic pulses (BiP) versus conventional DBS pulses (ClinDBS). Eleven ET subjects with clinically optimized ventralis intermedius nucleus DBS were enrolled. Objective measures were obtained over 3 h while ON BiP stimulation. There was observed benefit in the Fahn-Tolosa Tremor Rating Scale (TRS) for BiP conditions when compared to the DBS off condition and to ClinDBS setting. Total TRS scores during the DBS OFF condition (28.5 IQR = 24.5-35.25) were significantly higher than the other time points. Following active DBS, TRS improved to (20 IQR = 13.8-24.3) at ClinDBS setting and to (16.5 IQR = 12-20.75) at the 3 h period ON BiP stimulation (p = 0.001). Accelerometer recordings revealed improvement in tremor at rest (χ 2  = 16.1, p = 0.006), posture (χ 2  = 15.9, p = 0.007) and with action (χ 2  = 32.1, p=<0.001) when comparing median total scores at ClinDBS and OFF DBS conditions to 3 h ON BiP stimulation. There were no adverse effects and gait was not impacted. BiP was safe, tolerable and effective on the tremor symptoms when tested up to 3 h. This study demonstrated the feasibility of applying a novel DBS waveform in the clinic setting. Larger prospective studies with longer clinical follow-up will be required. Copyright © 2017. Published by Elsevier Ltd.

{sup 123}I-FP-CIT SPECT findings and its clinical relevance in prodromal dementia with Lewy bodies

Energy Technology Data Exchange (ETDEWEB)

Kasanuki, Koji [Juntendo University School of Medicine, PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo (Japan); Juntendo University School of Medicine, Department of Psychiatry, Tokyo (Japan); Mayo Clinic, Department of Neuroscience, Jacksonville, FL (United States); Iseki, Eizo; Ota, Kazumi [Juntendo University School of Medicine, PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo (Japan); Juntendo University School of Medicine, Department of Psychiatry, Tokyo (Japan); Kondo, Daizo; Sato, Kiyoshi [Juntendo University School of Medicine, PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo (Japan); Ichimiya, Yosuke; Arai, Heii [Juntendo University School of Medicine, Department of Psychiatry, Tokyo (Japan)

2017-03-15

Evidence for the prodromal stage of dementia with Lewy bodies (DLB) is very limited. To address this issue, we investigate the {sup 123}I-FP-CIT SPECT measure of dopamine transporter binding finding and its clinical relevance. We enrolled subjects into a prodromal DLB group (PRD-DLB) (n = 20) and clinical DLB group (CLIN-DLB) (n = 18) and compared these groups with an Alzheimer's disease control group (AD) (n = 10). PRD-DLB was defined as patients having the non-motor symptoms associated with Lewy body disease (LBD) [i.e. REM sleep behavior disorder (RBD), olfactory dysfunction, autonomic dysfunction, and depression] and showing characteristic diffuse occipital hypometabolism in {sup 18}F-FDG PET. CLIN-DLB was defined as patients fulfilling the established criteria of probable DLB. Striatal specific binding ratio (SBR) of {sup 123}I-FP-CIT SPECT was used for objective group comparisons. The correlations between SBR and cognitive function (MMSE), motor symptoms (UPDRS3), and duration of LBD-associated non-motor symptoms were compared between the two DLB groups. Mean SBR scores of both PRD-DLB and CLIN-DLB were significantly lower than those of AD. No correlation was found between SBR and MMSE scores. Both in the CLIN-DLB and total DLB groups, SBR scores were negatively correlated with UPDRS3 scores, whereas no correlation was found in PRD-DLB. Among the LBD-related non-motor symptoms, duration of olfactory dysfunction, and RBD demonstrated negative correlation with SBR scores in PRD-DLB. {sup 123}I-FP-CIT SPECT may play a role for detecting DLB among the subjects in prodromal stage. During this stage, long-term olfactory dysfunction and/or RBD may indicate more severe degeneration of the nigro-striatal dopaminergic pathway. (orig.)

"1"2"3I-FP-CIT SPECT findings and its clinical relevance in prodromal dementia with Lewy bodies

International Nuclear Information System (INIS)

Kasanuki, Koji; Iseki, Eizo; Ota, Kazumi; Kondo, Daizo; Sato, Kiyoshi; Ichimiya, Yosuke; Arai, Heii

2017-01-01

Evidence for the prodromal stage of dementia with Lewy bodies (DLB) is very limited. To address this issue, we investigate the "1"2"3I-FP-CIT SPECT measure of dopamine transporter binding finding and its clinical relevance. We enrolled subjects into a prodromal DLB group (PRD-DLB) (n = 20) and clinical DLB group (CLIN-DLB) (n = 18) and compared these groups with an Alzheimer's disease control group (AD) (n = 10). PRD-DLB was defined as patients having the non-motor symptoms associated with Lewy body disease (LBD) [i.e. REM sleep behavior disorder (RBD), olfactory dysfunction, autonomic dysfunction, and depression] and showing characteristic diffuse occipital hypometabolism in "1"8F-FDG PET. CLIN-DLB was defined as patients fulfilling the established criteria of probable DLB. Striatal specific binding ratio (SBR) of "1"2"3I-FP-CIT SPECT was used for objective group comparisons. The correlations between SBR and cognitive function (MMSE), motor symptoms (UPDRS3), and duration of LBD-associated non-motor symptoms were compared between the two DLB groups. Mean SBR scores of both PRD-DLB and CLIN-DLB were significantly lower than those of AD. No correlation was found between SBR and MMSE scores. Both in the CLIN-DLB and total DLB groups, SBR scores were negatively correlated with UPDRS3 scores, whereas no correlation was found in PRD-DLB. Among the LBD-related non-motor symptoms, duration of olfactory dysfunction, and RBD demonstrated negative correlation with SBR scores in PRD-DLB. "1"2"3I-FP-CIT SPECT may play a role for detecting DLB among the subjects in prodromal stage. During this stage, long-term olfactory dysfunction and/or RBD may indicate more severe degeneration of the nigro-striatal dopaminergic pathway. (orig.)

Computational Linguistics in the Netherlands 2004 : Selected papers from the fifteenth CLIN meeting

NARCIS (Netherlands)

Wouden, Ton van der; Poß, Michaela; Reckman, Hilke; Cremers, Crit

2005-01-01

This volume contains a selection of the papers presented at the fifteenth installment of Computational Linguistics in the Netherlands, held at Leiden University on Friday, December 17th, 2004. Organized by the computational linguists of what was at that time called the Leiden Centre for Linguistics

Acides gras oméga-3 et déclin cognitif : la controverse

Directory of Open Access Journals (Sweden)

Barberger-Gateau Pascale

2013-03-01

Full Text Available Basic research suggests a protective effect of the long-chain omega-3 polyunsaturated fatty acids – eicosapentaenoic acid (EPA and docosahexaenoic acid (DHA – against brain aging. In humans, many epidemiological studies have found an inverse association between fish consumption or high blood levels of EPA and DHA, and cognitive decline or risk of dementia. However, most randomized controlled trials with EPA and/or DHA supplements have failed to show any impact on cognitive decline. This paper analyses several reasons for such inconsistent results, including the time and duration of the supplementation, the cognitive and dietary inclusion criteria, the optimal doses of EPA and DHA, the interaction with genetic polymorphisms, and the need to consider synergistic effects between nutrients as they are provided by healthy diets.

Journal of Genetics | Indian Academy of Sciences

Indian Academy of Sciences (India)

Author Affiliations. NEHA SUDHIR1 TAJINDER KAUR2 ARCHANA BERI3 ANUPAM KAUR1. Department of Human Genetics, Guru Nanak Dev University, Amritsar 143 005, India; Hartej Hospital and Nursing Home, Amritsar 143 005, India; Beri Maternity Hospital, Southend Beri Fertility and IVF, Amritsar 143 005, India ...

Fulltext PDF

Indian Academy of Sciences (India)

the role of science and technology in the social and economic growth of ... ethics of medical research and GM crops; and regional gateways that cover ... technology-related courses at universities and higher education institutes, particularly ... Net's policy briefs and opinion articles for group discussions; and add SciDev.Net.

Main: FBA6 [TP Atlas

Lifescience Database Archive (English)

Full Text Available ctional analyses based on the solved structures were found to be effective - Functional analyses of plant-sp...ein complexes involved in the regulatory vesicular traffic in terms of functions and structures. Annu. Rev. Cell Dev. Biol.|Curr. Opin. Cell Biol. 19575639|20605430 FBA6.csml ...

Community based assessment on household management of waste ...

African Journals Online (AJOL)

Bernt Lindtjorn

Conclusion: in the study community household management of waste is in poor condition. Health-workers and local authorities must pay special emphasis to improve these conditions. Further in-depth studies should also be encouraged to look for improved interventions. [Ethiop. J. Health Dev. 2010;24(2):103-109].

The Effects of Low Level Prenatal Carbon Monoxide on Neocortical Development

Science.gov (United States)

2010-06-02

amount of NO available, which may have formed free radicals damaging the tissue and resulting in cell death. Treatment with a synthetic cGMP also failed...Watkinson B (36- and 48-month neurobehavioral follow-up of children prenatally exposed to marijuana , cigarettes, and alcohol. J Dev Behav Pediatr

Pramana – Journal of Physics | Indian Academy of Sciences

Indian Academy of Sciences (India)

Rangan Lahiri1 Arvind2 3 Anirban Sain4 5. Department of Physics, Indian Institute of Science, Bangalore 560 012, India; Department of Physics, Carnegie Mellon University, Pittsburgh, PA 15213, USA; Department of Physics, Guru Nanak Dev University, Amritsar 143 005, India; Department of Physics, University of ...

Orchestrating Docker

CERN Document Server

Holla, Shrikrishna

2015-01-01

If you are a competent developer or DevOps with a good understanding of Linux filesystems but want to manage and orchestrate Docker services, images, and products using a multitude of techniques, then this book is for you. No prior knowledge of Docker or container virtualization is required.

Self-Perceived Stability and Change in Children's Competence

Science.gov (United States)

Vandenplas-Holper, Christiane; Roskam, Isabelle; Fontaine, Anne-Marie

2010-01-01

Using Harter's ("Child Dev" 53(1):87-97, 1982) perceived competence scale, this study integrates several paradigms related to the issues of self-perceived competence, stability or change and attributional theory. It examines how 268 Belgian and Portuguese fifth graders consider their scholastic, social and physical competence at present…

Disease: H01837 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available lbar paresis (Worster- Drought syndrome) is a permanent movement disorder of the bulbar muscles causing persistent...ndrome: poorly recognized despite severe and persistent difficulties with feeding and speech. ... JOURNAL ... Dev Med Child Neurol 52:27-32 (2010) DOI:10.1111/j.1469-8749.2009.03475.x ...

20180312 - Profiling the ToxCast library with a pluripotent human (H9) embryonic stem cell assay (SOT)

Science.gov (United States)

The Stemina devTOX quickPredict platform (STM) is a human pluripotent H9 stem cell-based assay that predicts developmental toxicants. Using the STM model, we screened 1065 ToxCast chemicals and entered the data into the ToxCast data analysis pipeline. Model performance was 83.3% ...

Neurogenin1 Expression and Function in the Developing Mouse Cerebellum

Science.gov (United States)

2011-12-14

comic relief to everyone excluding perhaps Dr. Doughty. Krys provided an enormous amount of support and I thank her for playing a dual role as my lab...telencephalic neurons. Genes Dev 14:67-80. Frampton M (2008) Embodiments of Will: Anatomical and Physiological Theories of Voluntary Animal Motion from

Modeling Jambo wastewater treatment system to predict water re ...

African Journals Online (AJOL)

The main objective of this study was twofold: (i) to investigate how processes can be efficiently improved and optimized for environmental safety, and (ii) to develop Dev C++ programme to implement Brown's model for determining water quality usage of the effluent of the factory. Specifically, wastewater parameters ...

Experiment list: SRX882918 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available SRX882918 mm9 DNase-seq DNase-Seq Liver Liver MeSH Description=The number of offspring produced at one birth...C414-007 GAIIx strain=C57Bl/6 x Sv/129 || dev_stage=adult || sex=male || tissue=liver || birth_date=02/24/13

Experiment list: SRX882884 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available SRX882884 mm9 DNase-seq DNase-Seq Liver Liver MeSH Description=The number of offspring produced at one birth... TC414-013 HiSeq strain=C57Bl/6 x Sv/129 || dev_stage=adult || sex=male || tissue=liver || birth_date=03/20/

Experiment list: SRX882973 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available SRX882973 mm9 DNase-seq DNase-Seq Liver Liver MeSH Description=The number of offspring produced at one birth...C414-009 strain=C57Bl/6 x Sv/129 || dev_stage=adult || sex=male || tissue=liver || birth_date=02/24/13 || de

Experiment list: SRX882871 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available SRX882871 mm9 DNase-seq DNase-Seq Liver Liver MeSH Description=The number of offspring produced at one birth...ver TC414-007 HiSeq strain=C57Bl/6 x Sv/129 || dev_stage=adult || sex=male || tissue=liver || birth_date=02/

Experiment list: SRX883013 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available SRX883013 mm9 DNase-seq DNase-Seq Liver Liver MeSH Description=The number of offspring produced at one birth...TC414-014 strain=C57Bl/6 x Sv/129 || dev_stage=adult || sex=male || tissue=liver || birth_date=03/20/13 || d

Final Remedial Investigation/Baseline Risk Assessment for the Ravines and Beach Area Study of the Surplus Operable Unit, Fort Sheridan, Illinois. Volume 1: RI Text and RI Appendices A-I.

Science.gov (United States)

1998-04-13

ecoCOPCs (laboratory or field studies) for impairment of amphibian reproductive success . • Measurement Endpoint 3— results of site-specific fathead...Date: \\C\\2\\ \\Q^ Jcalculator Used: ’"\\(-Q).Q Form: Lc )ADII IG Ikeas . Dev.: t-e-ica Balance Used: SP I S O Aquatic

ACKNOWLEDGEMENTS

Indian Academy of Sciences (India)

R.Narasimhan(krishtel emaging)1461 1996 Oct 15 13:05:22

J M Bull, Southampton, UK. Chaofang Zhao, China. D Chandrasekharan, Mumbai, India. R Cullers, Kansas, USA. Danling Tang, Japan. A C Das, Ahmedabad, India. S K Dash, Delhi, India. Don Olson, USA, India. Dev Niyogi, Raleigh, NC, USA. Edward Monahan, USA. G Ekstrom, Cambridge, USA. Elgar Desa, Goa, India.

Two-texture zeros and near-maximal atmospheric neutrino mixing ...

Indian Academy of Sciences (India)

S Dev et al. Acknowledgements. RRG gratefully acknowledges the financial support provided by the University Grants. Commission (UGC), Govt. of India, under the Dr D S Kothari postdoctoral fellowship scheme. LS gratefully acknowledges the financial support provided by the UGC, Govt. of India under BSR RFMS scheme ...

The Role of Higher Level Adaptive Coding Mechanisms in the Development of Face Recognition

Science.gov (United States)

Pimperton, Hannah; Pellicano, Elizabeth; Jeffery, Linda; Rhodes, Gillian

2009-01-01

DevDevelopmental improvements in face identity recognition ability are widely documented, but the source of children's immaturity in face recognition remains unclear. Differences in the way in which children and adults visually represent faces might underlie immaturities in face recognition. Recent evidence of a face identity aftereffect (FIAE),…

A guild of 45 CRISPR-associated (Cas protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes.

Directory of Open Access Journals (Sweden)

Daniel H Haft

2005-11-01

Full Text Available Clustered regularly interspaced short palindromic repeats (CRISPRs are a family of DNA direct repeats found in many prokaryotic genomes. Repeats of 21-37 bp typically show weak dyad symmetry and are separated by regularly sized, nonrepetitive spacer sequences. Four CRISPR-associated (Cas protein families, designated Cas1 to Cas4, are strictly associated with CRISPR elements and always occur near a repeat cluster. Some spacers originate from mobile genetic elements and are thought to confer "immunity" against the elements that harbor these sequences. In the present study, we have systematically investigated uncharacterized proteins encoded in the vicinity of these CRISPRs and found many additional protein families that are strictly associated with CRISPR loci across multiple prokaryotic species. Multiple sequence alignments and hidden Markov models have been built for 45 Cas protein families. These models identify family members with high sensitivity and selectivity and classify key regulators of development, DevR and DevS, in Myxococcus xanthus as Cas proteins. These identifications show that CRISPR/cas gene regions can be quite large, with up to 20 different, tandem-arranged cas genes next to a repeat cluster or filling the region between two repeat clusters. Distinctive subsets of the collection of Cas proteins recur in phylogenetically distant species and correlate with characteristic repeat periodicity. The analyses presented here support initial proposals of mobility of these units, along with the likelihood that loci of different subtypes interact with one another as well as with host cell defensive, replicative, and regulatory systems. It is evident from this analysis that CRISPR/cas loci are larger, more complex, and more heterogeneous than previously appreciated.

Evaluating the Hydrologic Performance of Low Impact Development Scenarios in a Micro Urban Catchment

Science.gov (United States)

Li, Chunlin; Liu, Miao; Hu, Yuanman; Han, Rongqing; Shi, Tuo; Qu, Xiuqi; Wu, Yilin

2018-01-01

As urbanization progresses, increasingly impervious surfaces have changed the hydrological processes in cities and resulted in a major challenge for urban stormwater control. This study uses the urban stormwater model to evaluate the performance and costs of low impact development (LID) scenarios in a micro urban catchment. Rainfall-runoff data of three rainfall events were used for model calibration and validation. The pre-developed (PreDev) scenario, post-developed (PostDev) scenario, and three LID scenarios were used to evaluate the hydrologic performance of LID measures. Using reduction in annual runoff as the goal, the best solutions for each LID scenario were selected using cost-effectiveness curves. The simulation results indicated that the three designed LID scenarios could effectively reduce annual runoff volumes and pollutant loads compared with the PostDev scenario. The most effective scenario (MaxPerf) reduced annual runoff by 53.4%, followed by the sponge city (SpoPerf, 51.5%) and economy scenarios (EcoPerf, 43.1%). The runoff control efficiency of the MaxPerf and SpoPerf scenarios increased by 23.9% and 19.5%, respectively, when compared with the EcoPerf scenario; however, the costs increased by 104% and 83.6%. The reduction rates of four pollutants (TSS, TN, TP, and COD) under the MaxPerf scenario were 59.8–61.1%, followed by SpoPerf (53.9–58.3%) and EcoPerf (42.3–45.4%), and the costs of the three scenarios were 3.74, 3.47 and 1.83 million yuan, respectively. These results can provide guidance to urban stormwater managers in future urban planning to improve urban water security. PMID:29401747

Young Children's Reasoning About Physical & Behavioural Family Resemblance: Is There a Place for a Precursor Model of Inheritance?

Science.gov (United States)

Ergazaki, Marida; Alexaki, Aspa; Papadopoulou, Chrysa; Kalpakiori, Marieleni

2014-02-01

This paper aims at exploring (a) whether preschoolers recognize that offspring share physical traits with their parents due to birth and behavioural ones due to nurture, and (b) whether they seem ready to explain shared physical traits with a `pre-biological' causal model that includes the contribution of both parents and a rudimentary notion of genes. This exploration is supposed to provide evidence for our next step, which is the development of an early years' learning environment about inheritance. Conducting individual, semi-structured interviews with 90 preschoolers (age 4.5-5.5) of four public kindergartens in Patras, we attempted to trace their reasoning about (a) whether and why offspring share physical and behavioural traits with parents and (b) which mechanism could better explain the shared physical traits. The probes were a modified six-case version of Solomon et al. (Child Dev 67:151-171, 1996) `adoption task, as well as a three-case task based on Springer's (Child Dev 66:547-558, 1995) `mechanism task' and on Solomon and Johnson's (Br J Dev Psychol 18(1):81-96, 2000) idea of genes as a `conceptual placeholder'. The qualitative and quantitative analysis of the interviews showed overlapping reasoning about the origin of physical and behavioural family resemblance. Nevertheless, we did trace the `birth-driven' argument for the attribution of the offspring's physical traits to the biological parents, as well as a preference for the `pre-biological' model that introduces a rudimentary idea of genes in order to explain shared physical traits between parents and offspring. The findings of the study and the educational implications are thoroughly discussed.

Prolactin Test

Science.gov (United States)

... Macroprolactin Screening: Application of a New Strict Laboratory Definition of Macroprolactinemia. Clin ... by one of our partners, the American Society for Clinical Laboratory Science (ASCLS). Click on the ...

Pramana – Journal of Physics | Indian Academy of Sciences

Indian Academy of Sciences (India)

2015-01-28

Jan 28, 2015 ... Author Affiliations. Neeraj Kumar Kamal1 2 Pooja Rani Sharma3 2 Manish Dev Shrimali2. The Institute of Mathematical Sciences, CIT Campus, Chennai 600 113, India; Department of Physics, Central University of Rajasthan, Ajmer 305 801, India; The LNM Institute of Information Technology, Jaipur 302 ...

Pramana – Journal of Physics | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Pramana – Journal of Physics. Pooja Rani Sharma. Articles written in Pramana – Journal of Physics. Volume 84 Issue 2 February 2015 pp 237-247. Suppression of oscillations in mean-field diffusion · Neeraj Kumar Kamal Pooja Rani Sharma Manish Dev Shrimali · More Details Abstract Fulltext PDF.

Brief Report: Assessment of Intervention Effects on in Vivo Peer Interactions in Adolescents with Autism Spectrum Disorder (ASD)

Science.gov (United States)

Dolan, Bridget K.; Van Hecke, Amy V.; Carson, Audrey M.; Karst, Jeffrey S.; Stevens, Sheryl; Schohl, Kirsten A.; Potts, Stephanie; Kahne, Jenna; Linneman, Nina; Remmel, Rheanna; Hummel, Emily

2016-01-01

This study aimed to evaluate the effectiveness of a randomized controlled trial of a social skills intervention, the Program for the Education and Enrichment of Relational Skills (PEERS: Laugeson et al. in "J Autism Dev Disord" 39(4): 596-606, 2009), by coding digitally recorded social interactions between adolescent participants with…

76 FR 27645 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

Science.gov (United States)

2011-05-12

..., Inc., Wolsey, South Dakota; to acquire 100 percent of the voting shares of and merge with Kingsbury Bank Holding Company, and thereby indirectly acquire voting shares of Peoples State Bank, both in De Smet, South Dakota. Board of Governors of the Federal Reserve System, May 9, 2011. Robert deV. Frierson...

Literary Translation as a Tool for Critical Language Planning

Science.gov (United States)

Mooneeram, Roshni

2013-01-01

This paper argues that Dev Virahsawmy, an author who manipulates literary translation for the purposes of linguistic prestige formation and re-negotiation, is a critical language-policy practitioner, as his work fills an important gap in language planning scholarship. A micro-analysis of the translation of a Shakespearean sonnet into Mauritian…

Metabolism in time and space – exploring the frontier of developmental biology

Czech Academy of Sciences Publication Activity Database

Krejčí, Alena; Tennessen, J. M.

2017-01-01

Roč. 144, č. 18 (2017), s. 3193-3198 ISSN 0950-1991 Institutional support: RVO:60077344 Keywords : metabolism * mitochondria * aerobic glycolysis Subject RIV: EB - Genetics ; Molecular Biology OBOR OECD: Genetics and heredity (medical genetics to be 3) Impact factor: 5.843, year: 2016 http://dev.biologists.org/content/144/18/3193

Design of Alpha Voltaic Power Source Using Americium 241 (241Am) and Diamond with a Power Density of 10 mW/cm3

Science.gov (United States)

2017-10-19

Carroll JJ , Bayne S. Alpha Schottky junction energy source. SPIE; 2012. 29. Summers GP, Burke EA, Shapiro P, Messenger SR, Walters RJ. Damage...Elec Dev. 1694;11(1):2–8. 38. Loferski JJ , Rappaport P. Radiation damage in Ge and Si detected by carrier lifetime changes: damage thresholds. Phys

The Autism Diagnostic Observation Schedule, Module 4: Application of the Revised Algorithms in an Independent, Well-Defined, Dutch Sample (N = 93)

Science.gov (United States)

de Bildt, Annelies; Sytema, Sjoerd; Meffert, Harma; Bastiaansen, Jojanneke A. C. J.

2016-01-01

This study examined the discriminative ability of the revised Autism Diagnostic Observation Schedule module 4 algorithm (Hus and Lord in "J Autism Dev Disord" 44(8):1996-2012, 2014) in 93 Dutch males with Autism Spectrum Disorder (ASD), schizophrenia, psychopathy or controls. Discriminative ability of the revised algorithm ASD cut-off…

48 CFR 5152.208-9001 - Industrial preparedness planning.

Science.gov (United States)

2010-10-01

... planning. 5152.208-9001 Section 5152.208-9001 Federal Acquisition Regulations System DEPARTMENT OF THE ARMY... planning. As prescribed at 5108-070(g)(4) insert the following clause in full text in contracts where the contractor is designated a Limited Fee Planned Producer. Industrial Preparedness Planning (XXX 1989) (DEV) (a...

Re-Evaluation of Constant versus Varied Punishers Using Empirically Derived Consequences

Science.gov (United States)

Toole, Lisa M.; DeLeon, Iser G.; Kahng, Sung Woo; Ruffin, Geri E.; Pletcher, Carrie A.; Bowman, Lynn G.

2004-01-01

Charlop, Burgio, Iwata, and Ivancic [J. Appl. Behav. Anal. 21 (1988) 89] demonstrated that varied punishment procedures produced greater or more consistent reductions of problem behavior than a constant punishment procedure. More recently, Fisher and colleagues [Res. Dev. Disabil. 15 (1994) 133; J. Appl. Behav. Anal. 27 (1994) 447] developed a…

Fellowship | Indian Academy of Sciences

Indian Academy of Sciences (India)

Abrol, Dr Yash Pal Ph.D. (Chicago), FNA, FNASc, FNAAS. Date of birth: 23 December 1935. Specialization: Agriculture: Crop Physiology, Environmental Sciences Address: Chief Patron, Society for Conservation of Nature, Room No. F4, A Block, NASC Complex, Dev Prakash Shastry Marg, P.O. Pusa, New Delhi 110 012, ...

Appi - tarbijast võlgnik kolis välismaale! : kommentaar Riigikohtu lahenditele asjades 3-2-1-114-12 ja 3-2-1-123-12 / Karin Sein

Index Scriptorium Estoniae

Sein, Karin, 1974-

2013-01-01

Riigikohtu lahendist 3-2-1-114-12, milles vaieldi füüsilisest isikust võlgniku pankroti väljakuulutamise kohtualluvuse üle. Lahendist 3-2-1-123-12, milles vaieldi, kas ja millistel tingimustel on Eesti kohus pädev läbi vaatama hagi Eestist lahkunud tarbijast krediidisaaja vastu

Open Empowerment: Digital Natives, Democracy, and Security in ...

International Development Research Centre (IDRC) Digital Library (Canada)

Led by the SecDev Group, this research project will examine such issues in Latin America, where the contest between securitization and preservation of openness in cyberspace is driven by criminal activity. Researchers will combine a general panorama of organized crime and cyber-security with in-depth regional cases, ...

Does WISC-IV Underestimate the Intelligence of Autistic Children?

Science.gov (United States)

Nader, Anne-Marie; Courchesne, Valérie; Dawson, Michelle; Soulières, Isabelle

2016-01-01

Wechsler Intelligence Scale for Children (WISC) is widely used to estimate autistic intelligence (Joseph in The neuropsychology of autism. Oxford University Press, Oxford, 2011; Goldstein et al. in "Assessment of autism spectrum disorders." Guilford Press, New York, 2008; Mottron in "J Autism Dev Disord" 34(1):19-27, 2004).…

Peer-to-Peer Support for Science Journalism in the Developing ...

International Development Research Centre (IDRC) Digital Library (Canada)

IDRC has a long history of supporting the advancement of science journalism in the Third World. Since 2000, IDRC helped establish the London-based Science and Development Network (SciDev.Net) with regional nodes in developing countries and played a pivotal role in the Fourth Conference on Science Journalism ...

Youth Migration and Agricultural Production

African Journals Online (AJOL)

PROF. MADUKWE

The study investigated the causes and examined the effects of youth ... poverty and search for better education in the cities were the major causes of .... and women from farming (rural) communities engenders urban nuisance and .... Frequency Percentage Mean. St.Dev. Age. <30 years. 31-60 years. 61 years and above.

Strategies for Perceiving Facial Expressions in Adults with Autism Spectrum Disorder

Science.gov (United States)

Walsh, Jennifer A.; Vida, Mark D.; Rutherford, M. D.

2014-01-01

Rutherford and McIntosh (J Autism Dev Disord 37:187-196, 2007) demonstrated that individuals with autism spectrum disorder (ASD) are more tolerant than controls of exaggerated schematic facial expressions, suggesting that they may use an alternative strategy when processing emotional expressions. The current study was designed to test this finding…

South-South Collaboration in Health Biotechnology

International Development Research Centre (IDRC) Digital Library (Canada)

5.3 The geography of China's health biotechnology collaboration ..... and Argentina, Brazil, Chile, Mexico, Paraguay, Peru and Uruguay, for example, established ...... “Nations team up to share R&D skills in HIV/AIDS battle”, SciDev. ...... This reduces both dependence on international imports, and leads to the availability of ...

the current susceptibility pattern of methicillin resistant ...

African Journals Online (AJOL)

DJFLEX

RESISTANT STAPHYLOCOCCUS AUREUS TO ANTIBIOTICS IN. PORT HARCOURT ... pneumonia, urinary tract infections, wound sepsis, septic arthritis, osteomyelitis and .... in a neonatal and pediatric intensive care unit. Peditric-Med. Clin.

The Autism-Spectrum Quotient and Visual Search: Shallow and Deep Autistic Endophenotypes

Science.gov (United States)

Gregory, B. L.; Plaisted-Grant, K. C.

2016-01-01

A high Autism-Spectrum Quotient (AQ) score (Baron-Cohen et al. in "J Autism Dev Disord" 31(1):5-17, 2001) is increasingly used as a proxy in empirical studies of perceptual mechanisms in autism. Several investigations have assessed perception in non-autistic people measured for AQ, claiming the same relationship exists between…

The Antiaircraft Journal. Volume 92, Number 5, September-October 1949

Science.gov (United States)

1949-10-01

philosophical reflections on the subject of po’werand those to whom it should be entrusted. Recall the words of much-studied Machiavelli , than whom...Leavenworth. Kan. Rauch. A. R, Comm. of Basic Phys. Sc.• Res. & Dev. Board, Pentagon. \\Vash. 25. D. C. Rawls . J. W., Jr.. AFF Liaison Off.. Boeing Aircraft

Getting started with Hazelcast

CERN Document Server

Johns, Mat

2015-01-01

This book is a great introduction for Java developers, software architects, or DevOps looking to enable scalable and agile data within their applications. Providing in-memory object storage, cluster-wide state and messaging, or even scalable task execution, Hazelcast helps solve a number of issues that have troubled technologists for years.

Stemcell Information: SKIP000395 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available tochemistry Yes Teratoma formation ... Yes ... National Research Institute for Child Health and Dev...elopment 独立行政法人　国立成育医療研究センター研究所 Akihiro Umezawa 梅澤　明弘 Available National Research Institute for Child Health

Parents' Translations of Child Gesture Facilitate Word Learning in Children with Autism, Down Syndrome and Typical Development

Science.gov (United States)

Dimitrova, Nevena; Özçaliskan, Seyda; Adamson, Lauren B.

2016-01-01

Typically-developing (TD) children frequently refer to objects uniquely in gesture. Parents translate these gestures into words, facilitating children's acquisition of these words (Goldin-Meadow et al. in "Dev Sci" 10(6):778-785, 2007). We ask whether this pattern holds for children with autism (AU) and with Down syndrome (DS) who show…

Brief Report: Predicting Inner Speech Use amongst Children with Autism Spectrum Disorder (ASD)--The Roles of Verbal Ability and Cognitive Profile

Science.gov (United States)

Williams, David M.; Jarrold, Christopher

2010-01-01

Studies of inner speech use in ASD have produced conflicting results. Lidstone et al., J "Autism Dev Disord" (2009) hypothesised that Cognitive Profile (i.e., "discrepancy" between non-verbal and verbal abilities) is a predictor of inner speech use amongst children with ASD. They suggested other, contradictory results might be explained in terms…

Prevention of Post-Radiotherapy Failure in Prostate Cancer by Vitamin D

Science.gov (United States)

2005-03-01

cur- 55. Mitchell MF, Hittelman WN, Hong WK et al. The natural history cumin , a chemo preventive agent, in patients with high-risk or of cervical...chromosomal DNA loops during oxidative stress . Genes & Dev 13:1553-1560. 16 1999 Chen AY, Choy H and Rothenberg ML. DNA topoisomerase I-targeting drugs as

An Advanced Simulation Framework for Parallel Discrete-Event Simulation

Science.gov (United States)

Li, P. P.; Tyrrell, R. Yeung D.; Adhami, N.; Li, T.; Henry, H.

1994-01-01

Discrete-event simulation (DEVS) users have long been faced with a three-way trade-off of balancing execution time, model fidelity, and number of objects simulated. Because of the limits of computer processing power the analyst is often forced to settle for less than desired performances in one or more of these areas.

Child Autism Spectrum Disorder Traits and Parenting Stress: The Utility of Using a Physiological Measure of Parental Stress

Science.gov (United States)

Factor, Reina S.; Swain, Deanna M.; Scarpa, Angela

2018-01-01

Caregivers of children with autism spectrum disorder (ASD) report greater stress due to unique parenting demands (e.g.; Estes et al. in "Brain Dev" 35(2):133-138, 2013). Stress is often studied through self-report and has not been extensively studied using physiological measures. This study compared parenting stress in mothers of…

The Aged Microenvironment Influences Prostate Carcinogenesis

Science.gov (United States)

2008-12-01

Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor. PLoS Biol 2008, 6:e301 31. Jeyapalan JC, Ferreira M...Sedivy JM, Herbig U: Accumulation of senescent cells in mitotic tissue of aging primates. Mech Ageing Dev 2007, 128:36-44 32. Jeyapalan JC, Sedivy JM

Mechanism of Developmental Change in the PLAY Project Home Consultation Program: Evidence from a Randomized Control Trial

Science.gov (United States)

Mahoney, Gerald; Solomon, Richard

2016-01-01

This investigation is a secondary analysis of data from a randomized control trial of the PLAY Home Consultation Intervention Program which was conducted with 112 preschool children with Autism Spectrum Disorders and their parents (Solomon et al. in "J Dev Behav Pediatr" 35:475-485, 2014). Subjects were randomly assigned to either a…

Basin F Overburden and Soil Sampling and Analysis Study, Rocky Mountain Arsenal

Science.gov (United States)

1982-05-01

and the material lodged in the shoe of the sampler z•s pressed out and placed in the bottom of the sleeve. In tnis tray, an undisturbed sample of the...b):______ A. Szandard dev--aciol of lowiest stanidard (S): _____ jmmzltnof lzw.sz standard (c): _______ i~veraq* &ýs-: banca cý lovesc standard

The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling

NARCIS (Netherlands)

Budry, L.; Balsalobre, A.; Gauthier, Y.; Khetchoumian, K.; L'Honore, A.; Vallette-Kasic, S.; Brue, T; Figarella-Branger, D.; Meij, B.P.; Drouin, J.

2012-01-01

Genes Dev. 2012 Oct 15;26(20):2299-310. doi: 10.1101/gad.200436.112. The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling. Budry L, Balsalobre A, Gauthier Y, Khetchoumian K, L'honoré A, Vallette S, Brue T, Figarella-Branger D, Meij B,

Disease: H01841 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available ncephalopathy in Japan, and is often observed in children with neurological problems, such as intellectual d...kasaka M, Anzai Y, Mizuguchi M ... TITLE ... Clinical and genetic features of acute encephalopathy in childr...en taking theophylline. ... JOURNAL ... Brain Dev 37:463-70 (2015) DOI:10.1016/j.braindev.2014.07.010

Plane strain problem in microstretch elastic solid

Indian Academy of Sciences (India)

R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

College, Patti 143 416, India. 3Department of Mathematics, Guru Nanak Dev University, Amritsar 143 005, ... lem in microstretch elastic solid by employing the eigenvalue approach. 975. Page 2. 976. Rajneesh Kumar et al. 2. Basic equations ..... of the matrix A are characteristic roots of (29) assuming that real parts of qs.

Regulation of Breast Cancer Stem Cell by Tissue Rigidity

Science.gov (United States)

2014-06-01

metastasis. Cancer Cell 20: 576– 590 . Ledford H. 2011. Cancer theory faces doubts. Nature 472: 273. Lee KE, Bar-Sagi D. 2010. Oncogenic KRas suppresses...blocks the cell cycle and confers resistance to cell death. Genes Dev 18: 1131–1143. Vesuna F, Lisok A, Kimble B, Raman V. 2009. Twist modulates

Spectrochemical analysis by atomic absorption and emission

National Research Council Canada - National Science Library

Lajunen, Lauri

1992-01-01

... of these techniques. Inductively coupled plasma mass spectrometry (ICP-MS) has become a 'hot' analytical technique during the last few years, and is being used in many branches of science. Since the publication of my previous book 'Atomispektrometria' (in Finnish) in 1986, various techniques in analytical atomic spectroscopy have undergone significant dev...

76 FR 55849 - Federal Acquisition Regulation; Constitutionality of Federal Contracting Programs for Minority...

Science.gov (United States)

2011-09-09

... benefits (including potential economic, environmental, public health and safety effects, distributive... addresses shown below on or before November 8, 2011 to be considered in the formation of the final rule... Circuit decided in its favor (Rothe Dev. Corp. v. DoD, 545 F.3d 1023 (Fed. Cir. November 4, 2008)). The U...

Disease: H00773 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available ons in patients with characteristic facial features, intellectual disability, autistic behaviors and epile...psy. ... JOURNAL ... Clin Genet 87:356-61 (2015) DOI:10.1111/cge.12394 ... PMID:27108799 (

Chronic Allium sativum administration alters spontaneous ...

African Journals Online (AJOL)

Arun Kumar Agnihotri

investigate the effects of Allium sativum extract on the medial prefrontal cortex and neurobehaviour of adult ... KEY WORDS: Allium sativum; Medial prefrontal cortex; Neurobehaviour;. Histomorphology ..... brain atrophy mouse model. Clin Exp.

Pro website development and operations streamlining DevOps for large-scale websites

CERN Document Server

Sacks, Matthew

2012-01-01

Pro Website Development and Operations gives you the experience you need to create and operate a large-scale production website. Large-scale websites have their own unique set of problems regarding their design-problems that can get worse when agile methodologies are adopted for rapid results. Managing large-scale websites, deploying applications, and ensuring they are performing well often requires a full scale team involving the development and operations sides of the company-two departments that don't always see eye to eye. When departments struggle with each other, it adds unnecessary comp

Buys-Ballot Modeling of Nigerian Domestic Crude Oil Production ...

African Journals Online (AJOL)

PROF. O. E. OSUAGWU

2013-09-01

Sep 1, 2013 ... fluctuations about the trend. (iv). The irregular, random .... Mean 2.309 2.317 2.227 2.186 2.249 2.251 2.296 2.307 2.343 2.381 2.247 2.244. Std. Dev .... In v. S q r. Fig. 3: Time Plot of the Inverse Square Root Transformed Data ...

Phenotype-gene: 345 [Arabidopsis Phenome Database[Archive

Lifescience Database Archive (English)

Full Text Available an named peduncle during process named trichome morphogenesis for AT2G30432 Wang Shucai et al. 2007 Nov. Dev...an named peduncle during process named trichome morphogenesis http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u774i AT2G30432

Effects of auxins on in vitro reserve compounds of Phalaenopsis ...

African Journals Online (AJOL)

SAM

2014-03-26

Mar 26, 2014 ... Micropropagation of oca on a high sucrose medium promotes starch accumulation and plant establishment in soil. New Zeal. J. Crop Hort. 21:91-93. De Klerk GJ (2002). Rooting of microcuttings: theory and practice. In. Vitro Cel. Dev.-Pl. 38:415-422. Debergh PC, Maene LJ (1981). A scheme for commercial ...

Effectiveness of Cognitive, Exposure, and Skills Group Manualized Treatments in OIF/OEF Female Veterans

Science.gov (United States)

2013-04-01

Manuscript submitted for publication. Escalona, R., Achilles, G., Waitzkin, H, & Yager, J. (2004). PTSD and somatization in women treated at a VA...clinically significant elevations (> 70) on the Demoralization, Somatic Complaints, Low Positive Emotion of the Restructured Clinical scales and... Hypochondriasis , Psych Dev = Psychopathic Deviate, Masc-Fem = Masculinity- Femininity, Psychasth = Psychasthenia, Schizoph = Schizophrenia; Soc Introv

Scanning the Human Genome for Novel Therapeutic Targets for Breast Cancer

Science.gov (United States)

2005-04-01

971-974. 3. Maeda, I., Kohara , Y., Yamamoto, M. & Sugimoto, A. (2001) Cur,. Biol. 11, 19. Goshima, G. & Vale, R. D. (2003) Cell Biot. 162, 1003-1016...Tijsterman, M. (2003) Genes Dev. 17, 443-448. 22. Maeda, L., Kohara , Y., Yamamoto, M. & Sugimoto, A. (2001) Curt. Biol. 11, 6. Somma, M. P., Fasulo, B., Cenci

Development of C++ Application Program for Solving Quadratic Equation in Elementary School in Nigeria

Science.gov (United States)

Bandele, Samuel Oye; Adekunle, Adeyemi Suraju

2015-01-01

The study was conducted to design, develop and test a c++ application program CAP-QUAD for solving quadratic equation in elementary school in Nigeria. The package was developed in c++ using object-oriented programming language, other computer program that were also utilized during the development process is DevC++ compiler, it was used for…

Effects of hydrochlorothiazide and furosemide on creatinine ...

African Journals Online (AJOL)

SERVER

2008-04-03

term effects of hydrochlorothiazide on renal hemodynamics in essential hypertension. Clin. Sci. 56: 463. Wienen W, Schierok HJ (2001). Effect of telmisartan, hydrochlo- rothiazide and their combination on blood pressure and ...

Determining the static electronic and vibrational energy correlations via two-dimensional electronic-vibrational spectroscopy

Energy Technology Data Exchange (ETDEWEB)

Dong, Hui; Lewis, Nicholas H. C.; Oliver, Thomas A. A.; Fleming, Graham R., E-mail: grfleming@lbl.gov [Department of Chemistry, University of California, Berkeley, California 94720 (United States); Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, Californial 94720 (United States); Kavli Energy NanoSciences Institute at Berkeley, Berkeley, California 94720 (United States)

2015-05-07

Changes in the electronic structure of pigments in protein environments and of polar molecules in solution inevitably induce a re-adaption of molecular nuclear structure. Both changes of electronic and vibrational energies can be probed with visible or infrared lasers, such as two-dimensional electronic spectroscopy or vibrational spectroscopy. The extent to which the two changes are correlated remains elusive. The recent demonstration of two-dimensional electronic-vibrational (2DEV) spectroscopy potentially enables a direct measurement of this correlation experimentally. However, it has hitherto been unclear how to characterize the correlation from the spectra. In this paper, we present a theoretical formalism to demonstrate the slope of the nodal line between the excited state absorption and ground state bleach peaks in the spectra as a characterization of the correlation between electronic and vibrational transition energies. We also show the dynamics of the nodal line slope is correlated to the vibrational spectral dynamics. Additionally, we demonstrate the fundamental 2DEV spectral line-shape of a monomer with newly developed response functions.

Premonitory Urge for Tics Scale (PUTS): replication and extension of psychometric properties in youth with chronic tic disorders (CTDs).

Science.gov (United States)

Raines, Jeremy M; Edwards, Kimberly R; Sherman, Martin F; Higginson, Christopher I; Winnick, Joel B; Navin, Kelly; Gettings, Julie M; Conteh, Fatmata; Bennett, Shannon M; Specht, Matthew W

2018-04-01

Individuals with chronic tic disorders (CTDs) frequently describe aversive subjective sensory sensations that precede their tics. The first aim of the present study was to explore the psychometric properties of a standardized self-report measure to assess premonitory urges in CTDs, The Premonitory Urge for Tics Scale (PUTS), by replicating the analyses of Woods et al. (J Dev Behav Pediatr 26:397-403, 2005) using a sample twice the size of theirs. The second aim was to conduct an exploratory factor analysis of the PUTS. Eighty-four youth with CTDs, recruited from a pediatric OCD and tic specialty clinic, completed the PUTS while their caregivers completed The Parent Tic Questionnaire (PTQ) and a demographic measure. Consistent with (Woods et al. J Dev Behav Pediatr 26:397-403, 2005), the PUTS was found to be internally consistent (α = 0.82) and significantly correlated with overall tic severity as measured by the PTQ (r = 0.24, p tics than the frequency or intensity of tics.

Disease: H01505 [KEGG MEDICUS

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Full Text Available H01505 Inclusion body myositis Inclusion body myositis (IBM) is the most frequent ...imachkie MM, Barohn RJ ... TITLE ... Inclusion body myositis. ... JOURNAL ... Neurol Clin 32:629-46, vii (2014) DO

Intestinal failure in childhood

African Journals Online (AJOL)

Insulin influences intestinal structure and absorptive function.36 The favourable effect of .... lipid emulsions, micronutrients provison and cyclic infusion.3 The guidelines on PN .... Classification, epidemiology and aetiology. Best Pract Res Clin ...

Evaluation of marginal/internal fit of chrome‑cobalt crowns: Direct ...

African Journals Online (AJOL)

2014-11-03

Nov 3, 2014 ... computer‑aided design and computer‑aided manufacturing. Niger J Clin ... All of these reasons, manufacturers increasingly are choosing these ... fabricated using these different production techniques with. 32 specimens in ...

Disease: H01071 [KEGG MEDICUS

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Full Text Available DH2 locus on alcohol metabolism, sensitivity, consumption, and dependence in Europeans. ... JOURNAL ... Alcohol Clin Exp Res 30:1093-100 (2006) DOI:10.1111/j.1530-0277.2006.00128.x ...

Brief Report: Preliminary Evaluation of the Theory of Mind Inventory and Its Relationship to Measures of Social Skills

Science.gov (United States)

Lerner, Matthew D.; Hutchins, Tiffany L.; Prelock, Patricia A.

2011-01-01

This study presents updated information on a parent-report measure of Theory of Mind (ToM), formerly called the Perception of Children's Theory of Mind Measure (Hutchins et al., "J Autism Dev Disord" 38:143-155, 2008), renamed the Theory of Mind Inventory (ToMI), for use with parents of children with autism spectrum disorder (ASD). This study…

Improving Synchronization and Functional Connectivity in Autism Spectrum Disorders through Plasticity-Induced Rehabilitation Training

Science.gov (United States)

2011-08-01

theory  of   mind :  evidence  from...Faces  in  2  and  4-­‐Year-­‐Old   Children  with   Autism  Spectrum  Disorder.   J.Autism  Dev.Disord..   Hadjikhani,  N...Connectivity in Autism Spectrum Disorders through Plasticity-Induced Rehabilitation Training PRINCIPAL INVESTIGATOR: Jaime A. Pineda,

In the eyes of the beholder: Understanding subtypes of social withdrawal among young Chinese children.

Science.gov (United States)

Cheah, Charissa S L; Xu, Yiyuan

2015-06-01

In this commentary on Ding et al. (Brit. J. Dev. Psychol., 2015; 33, 159-173), we focus on the following: (1) the authors' use of vignettes portraying various prototypes of withdrawn children and (2) the cultural interpretation of their findings. We end with some suggestions for future research. © 2015 The British Psychological Society.

A Replication and Extension of the PEERS Intervention: Examining Effects on Social Skills and Social Anxiety in Adolescents with Autism Spectrum Disorders

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Schohl, Kirsten A.; Van Hecke, Amy V.; Carson, Audrey Meyer; Dolan, Bridget; Karst, Jeffrey; Stevens, Sheryl

2014-01-01

This study aimed to evaluate the Program for the Education and Enrichment of Relational Skills (PEERS: Laugeson et al. in "J Autism Dev Disord" 39(4):596-606, 2009). PEERS focuses on improving friendship quality and social skills among adolescents with higher-functioning ASD. 58 participants aged 11-16 years-old were randomly assigned to…

12om Limited Objective Experiment #2: Final Results Summary and Recommendations

Science.gov (United States)

2014-03-31

Acronym Definition ARP CD CF CFD CG CIM COA CONOPS CSE Dev DFATD DP DRDC FGS Gov HREC IDP KR LOE LOC MA MARS NASA TLX NGO OP OPP Ops ROC SA...weight Ratings (OPP Support) Ratings (IP) Ratings (CU) Ratings (CS) Ratings (Usability) Ratings (Training T/E) Ratings (Use T/E) NASA TLX Mental demand

Investigating Young Children's Perceptions of Body Size and Healthy Habits

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Xu, Tingting; Nerren, Jannah S.

2017-01-01

Attitudes and biases toward body size perceived as fat and body size perceived as thin are present in young children (Cramer and Steinwert in "J Appl Dev Psychol" 19(3):429-451, 1998; Worobey and Worobey in "Body Image" 11:171-174, 2014). However, the information children have regarding body size and ways to modify body size…

The Effectiveness of Cognitive Exposure & Skills Group Manualized Treatments in OIF/OEF Female Veterans

Science.gov (United States)

2011-04-01

2004). PTSD and somatization in women treated at a VA primary care clinic. Psychosomatics, 45, 291-296. Foa, E. B., Dancu, C. V., Hembree, E...were clinically significant elevations (> 70) on the Demoralization, Somatic Complaints, Low Positive Emotion of the Restructured Clinical scales and... Hypochondriasis , Psych Dev = Psychopathic Deviate, Masc-Fem = Masculinity- Femininity, Psychasth = Psychasthenia, Schizoph = Schizophrenia; Soc Introv

Resonant spin-flavor precession constraints on the neutrino ...

Indian Academy of Sciences (India)

Home; Journals; Pramana – Journal of Physics; Volume 61; Issue 1. Resonant spin-flavor precession constraints on the neutrino parameters and the twisting structure of the solar magnetic fields from the solar neutrino data. S Dev Jyoti Dhar Sharma U C Pandey S P Sud B C Chauhan. Research Articles Volume 61 Issue 1 ...

Comparative Analysis of Angiogenic Gene Expression in Normal and Impaired Wound Healing in Diabetic Mice: Effects of Extracorporeal Shock Wave Therapy

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2010-01-01

an impaired wound was able to tum-on and/or augment for a prolonged period a number of key proangiogenic genes which were previously silent , and...Lania G, Zhang Z, Huynh T et al (2009) Early thyroid devel- opment requires a Tbxl-Fgf8 pathway. Dev Bioi 328(1):109-117 58. Terasaki K, Kanzaki T

Résultats de recherche | Page 175 | CRDI - Centre de recherches ...

International Development Research Centre (IDRC) Digital Library (Canada)

Ce n'est pas d'hier que le CRDI appuie l'avancement du journalisme scientifique dans le Tiers-Monde. Depuis 2000, le CRDI a aidé à mettre en place le Réseau Sciences et Développement (SciDev.Net). Projet. Résilience et moyens de subsistance au lendemain de catastrophes naturelles. Les catastrophes naturelles ...

Autism Diagnostic Interview-Revised (ADI-R) Algorithms for Toddlers and Young Preschoolers: Application in a Non-US Sample of 1,104 Children

Science.gov (United States)

de Bildt, Annelies; Sytema, Sjoerd; Zander, Eric; Bölte, Sven; Sturm, Harald; Yirmiya, Nurit; Yaari, Maya; Charman, Tony; Salomone, Erica; LeCouteur, Ann; Green, Jonathan; Bedia, Ricardo Canal; Primo, Patricia García; van Daalen, Emma; de Jonge, Maretha V.; Guðmundsdóttir, Emilía; Jóhannsdóttir, Sigurrós; Raleva, Marija; Boskovska, Meri; Rogé, Bernadette; Baduel, Sophie; Moilanen, Irma; Yliherva, Anneli; Buitelaar, Jan; Oosterling, Iris J.

2015-01-01

The current study aimed to investigate the Autism Diagnostic Interview-Revised (ADI-R) algorithms for toddlers and young preschoolers (Kim and Lord, "J Autism Dev Disord" 42(1):82-93, 2012) in a non-US sample from ten sites in nine countries (n = 1,104). The construct validity indicated a good fit of the algorithms. The diagnostic…

Genetics Home Reference: Stormorken syndrome

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... ichthyosis), headaches, and difficulty with reading and spelling (dyslexia). Related Information What does it mean if a ... new syndrome: thrombocytopathia, muscle fatigue, asplenia, miosis, migraine, dyslexia and ichthyosis. Clin Genet. 1985 Nov;28(5): ...

Eosinophilic esophagitis

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... of the American Academy of Allergy, Asthma and Immunology. Dietary therapy and nutrition management of eosinophilic esophagitis: ... of the American Academy of Allergy, Asthma, and Immunology. J Allergy Clin Immunol Pract . 2017;5(2): ...

Genetics Home Reference: Burn-McKeown syndrome

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... Condition bilateral choanal atresia, cardiac defects, deafness, and dysmorphic appearance BMKS choanal atresia-hearing loss-cardiac defects- ... C, Wagget J, Bray R, Goodship J. New dysmorphic syndrome with choanal atresia in siblings. Clin Dysmorphol. ...

Anal itching -- self-care

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... chap 129. Ansari P. Pruritus ani. Clin Colon Rectal Surg . 2016;29(1):38-42. PMID: 26929750 ... Copyright 1997-2018, A.D.A.M., Inc. Duplication for commercial use must be authorized in writing ...

Disease: H00579 [KEGG MEDICUS

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Full Text Available to the missense mutations in the COL4A1 in basement membranes. The renal manifestations include hematuria an...erited diseases of the glomerular basement membrane. ... JOURNAL ... Nat Clin Pract N

Effect of Bridelia ferruginea (Euphorbiaceae) Leaf Extract on ...

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Keywords: Sucrose-induced, Glucose intolerance, Bridelia ferruginea, Hypoglycaemia, Metformin,. Tolbutamide. .... incubation medium (pH 7.4) contained (in. mMol/l): 122 ... ethanesulfonic acid (HEPES), as well as 0.5 ..... J Clin Invest 2009;.

Effect of routine preoperative fasting on residual gastric volume and ...

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2016-02-10

Feb 10, 2016 ... Key words: Fasting, myomectomy, pH, residual gastric volume. Date of Acceptance: ... gastric volume and acid in patients undergoing myomectomy. Niger J Clin ..... of gastric residual volume: A simulated, controlled study.

IGF-1 (Insulin-Like Growth Factor -1) Test

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... Testing Triglycerides Troponin Tryptase Tumor Markers Uric Acid Urinalysis Urine Albumin and Albumin/Creatinine Ratio Urine Culture ... Sheppard, M. (2007 April 3). Growth Hormone Assay Standardization: An Important Clinical Advance. Medscape from Clin Endocrinol . ...

African Journal of Neurological Sciences 2011 - Vol. 30, No 1 http ...

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AJNS WEBMASTERS

Keys words: stroke survivors, quality of life, anxiety, depression, Togo. RESUME. Introduction ..... lymphoma treated with standard-dose chemotherapy or local therapy. J Clin Oncol 2005 ... Lancet Oncol 2005;6:287-294. 6. BROWN MM ...

Original Research Article

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UP Employee

Honey samples were obtained from the different agro-ecological zones of Nigeria including: the tropical .... The clinical isolates of bacterial species ... This was introduced ..... produced by honey bees (Apis mellifera) ... American J. Clin. Pathol.

Delayed diagnosis of bullous pyoderma gangrenosum with acute ...

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2016-05-10

May 10, 2016 ... Infectious Disease, School of Medicine, Inönü University, Malatya, Turkey. Access this article online .... because prompt administration of glucocorticoids or other immunosuppressive ... corneal keratolysis. Am J Clin Pathol ...

Genetics Home Reference: mucolipidosis II alpha/beta

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... Mucolipidosis II (I-cell disease) and mucolipidosis IIIA (classical pseudo-hurler polydystrophy) are caused by mutations in ... N-acetylglucosamine-1-phosphotransferase gene (GNPTAB) in a French Canadian founder population. Clin Genet. 2008 Mar;73( ...

Disease: H00096 [KEGG MEDICUS

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Full Text Available ommittee. ... JOURNAL ... J Allergy Clin Immunol 120:776-94 (2007) DOI:10.1016/j.jaci.2007.08.053 ...e from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification C

Fungal Culture Test: MedlinePlus Lab Test Information

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... MB, Paes RD, Schuback AO. Sporothrix schenckii and Sporotrichosis. Clin Microbial Rev [Internet]. 2011 Oct [cited 2017 ... Atlanta: U.S. Department of Health and Human Services; Sporotrichosis [updated 2016 Aug 18; cited 2017 Oct 8]; [ ...

Effect of L-carnitine supplementation on drake semen quality

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sp3

2014-01-30

Jan 30, 2014 ... This study was conducted to determine the effect on semen quality traits of supplementing the diets of. Iraqi drakes with L-carnitine. ... Keywords: Carnitine, ducks, reproductive performance ..... clinical result. Drug Exp. Clin.

Genetics Home Reference: osteogenesis imperfecta

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... 2008 Jul;40(7):927. Citation on PubMed Cole WG. Advances in osteogenesis imperfecta. Clin Orthop Relat ... medicine? What is newborn screening? New Pages Lyme disease Fibromyalgia White-Sutton syndrome All New & Updated Pages ...

Disease: H01930 [KEGG MEDICUS

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Full Text Available e syndrome with nodular heterotopia. ... JOURNAL ... Clin Genet 90:258-62 (2016) DOI:10.1111/cge.12773 ... ...Taylor JC, Kini U ... TITLE ... A de novo frameshift in HNRNPK causing a Kabuki-lik

Genetics Home Reference: X-linked adrenoleukodystrophy

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... PubMed Wanders RJ, Waterham HR. Peroxisomal disorders I: biochemistry and genetics of peroxisome biogenesis disorders. Clin Genet. ... not be used as a substitute for professional medical care or advice. Users with questions about a ...

Genetics Home Reference: Léri-Weill dyschondrosteosis

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... for This Condition DCO dyschondrosteosis Leri-Weill dyschondrosteosis LWD Related Information How are genetic conditions and genes ... of SHOX/PAR1 duplications in Leri-Weill dyschondrosteosis (LWD) and idiopathic short stature (ISS). J Clin Endocrinol ...

Investigation of in vitro Mineral Forming Bacterial Isolates from Subgingival Calculus

Directory of Open Access Journals (Sweden)

Turgut Demir

2014-06-01

This is the first report to identify and show that bacteria from subgingival calculus under anaerobic conditions are involved in the formation of dental calculus. [Arch Clin Exp Surg 2014; 3(3.000: 153-160

Travelers' Health: Immunocompromised Travelers

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... TNF blocker Ibritumomab tiuxetan Zevalin CD20 with radioisotope Ibrutinib Imbruvica Tyrosine kinase inhibitor Imatinib mesylate Gleevec, STI ... of Health, and HIV Medicine Association of the Infectious Diseases Society of America. Clin Infect Dis. 2014 ...

Genetics Home Reference: Allan-Herndon-Dudley syndrome

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... cells in the developing brain. This hormone, called triiodothyronine or T3, is produced by a butterfly-shaped ... with X-linked psychomotor retardation and elevated serum triiodothyronine. J Clin Endocrinol Metab. 2007 Jun;92(6): ...

Salivary Secretion and Composition in Malaria: A Case-control Study

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olayemitoyin

However, presence of oral symptoms in these individuals may not be attributed to the reduced salivary ... the oral cavity and salivary composition and secretion. Assessment of ..... microbiota in children with acute otitis media. Clin. Microbiol.

Genetics Home Reference: pseudocholinesterase deficiency

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... BCHE) genotyping for post-succinylcholine apnea in an Australian population. Clin Chem. 2003 Aug;49(8):1297- ... API Site Map Subscribe Customer Support USA.gov Copyright Privacy Accessibility FOIA Viewers & Players U.S. Department of ...

Acceptance of a ready-to-use supplementary food by stable HIV ...

African Journals Online (AJOL)

2013-07-02

Jul 2, 2013 ... by stable HIV-treated and HIV and tuberculosis. (co-infected)-treated ...... pulmonary tuberculosis and undernutrition: evidence for anabolic block in tuberculosis. Clin Sci.1998 ... among poor Mexican women. J Nutr. 2010 ...

Lost Terranes of Zealandia: possible development of late Paleozoic and early Mesozoic sedimentary basins at the southwest Pacific margin of Gondwanaland, and their destination as terranes in southern South America Terrenos perdidos de Zealandia: posible desarrollo de cuencas sedimentarias del Paleozoico tardío y Mesozoico temprano en el margen suroccidental del Pacífico de Gondwana y su destino como terrenos en el sur de América del Sur

Directory of Open Access Journals (Sweden)

Christopher J Adams

2010-07-01

Full Text Available Latest Precambrian to Ordovician metasedimentary successions and Cambrian-Ordovician and Devonian-Carboniferous granitoids form the major part of the basement of southern Zealandia and adjacent sectors of Antarctica and southeast Australia. Uplift/cooling ages of these rocks, and local Devonian shallow-water cover sequences suggest that final consolidation of the basement occurred through Late Paleozoic time. A necessary consequence of this process would have been contemporaneous erosion and the substantial development of marine sedimentary basins at the Pacific margin of Zealandia. These are found nowhere at the present day, suggesting that the basins have been lost by tectonic erosion, perhaps in a margin-parallel dextral translation similar to late Paleozoic-Mesozoic suspect terranes of New Zealand. Aprobable detrital zircon age pattern is assembled for these lost Zealandia sediments, and then compared with those of pre-Jurassic (probable Triassic to Devonian metasedimentary rocks in the Chilean archipelago. Significant Mesoproterozoic, latest Neoproterozoic-Cambrian and Devonian-Carboniferous detrital zircon age components are common to both, thus supporting a possible Chilean terrane destination for these 'lost terranes of Zealandia'.Las sucesiones metasedimentarias del Precámbrico tardío al Ordovícico y granitoides del Cámbrico-Ordovícico y Devónico-Carbonífero constituyen la mayor parte del basamento del sur de Zealandia y sectores adyacentes de la Antartica y el sudeste de Australia. Las edades de enfriamiento/alzamiento de estas rocas y la cobertura local de secuencias de aguas someras del Devónico, sugieren que la consolidación definitiva del basamento se produjo durante el Paleozoico tardío. Una consecuencia necesaria de este proceso habría sido la erosion contemporánea y el desarrollo sustancial de cuencas sedimentarias marinas en el margen del Pacífico de Zealandia. Estas no se encuentran en ninguna parte en la

The association between asymptomatic and mild neurocognitive ...

African Journals Online (AJOL)

2018-04-12

Apr 12, 2018 ... Southern African Journal of HIV Medicine. ISSN: (Online) ... measures by medication possession ratio (MPR) and simplified medication adherence ..... Ann Intern Med. 2000 ... J Am Geriatr Soc. 2005 ... J AIDS Clin Res. 2013 ...

Afican Health Sciences Vol 9 No 1.pmd

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Administrator

2007-07-19

Jul 19, 2007 ... in the management of cases of sterility/infertility in women. The present ..... Safety of phytosterol esters. Part 1. Assessment of oestrogenicity using a combination of in vivo ... phytoestrogens isolated from beer. Alcohol. Clin.

Genetics Home Reference: combined pituitary hormone deficiency

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... my area? Other Names for This Condition CPHD panhypopituitarism Related Information How are genetic conditions and genes ... Mody S, Brown MR, Parks JS. The spectrum of hypopituitarism caused by PROP1 mutations. Best Pract Res Clin ...

Axial Length/Corneal Radius of Curvature Ratio and Refractive ...

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2017-06-14

Jun 14, 2017 ... of individuals,[2,5-8] the relationship between CR and refractive status ... the relationship between refractive error and ocular .... AG, 07740 Jena Germany). ..... adult population in rural Myanmar: The Meiktila eye study. Clin.

Molecular analysis of gut microbiota in obesity among Indian ...

Indian Academy of Sciences (India)

2012-08-14

Aug 14, 2012 ... also harbours trillions of bacteria, which affect our health ...... Polysaccharide utilization by gut bacteria: potential for new insights from genomic .... Wexler HM 2007 Bacteroides: the good, the bad and the nitty- gritty. Clin.

Infant-feeding knowledge and the practices of mothers

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2012-05-07

May 7, 2012 ... Original Research: Infant-feeding knowledge and the practices of mothers and caregivers. 2013;26(1). S Afr J Clin ... interventions, such as promotion of exclusive breastfeeding. Abstract ..... nutritional benefits. The other half ...

Do Clinical Symptoms and Signs Predict Reduced Renal Function ...

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establish chronicity, screening strategies are poorly defined. ... different risk score models. We plotted receiver ... Do you feel that in past 3 months your appetite has reduced ..... index of renal function: New insights into old concepts. Clin.

Oloruntoba et al (4)

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DELL

The significant difference between glucose oxidase and point-of-care testing noted in this ... evaluation and effective management of patients with diabetes mellitus. ..... Clin Lab. Med.29(3):511–22. American Diabetes Association, 1996. Self-.

ORIGINAL ARTICLES

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monoclonal amphetamine-assay result of antipsychotic drug therapy. Clin Chern 1993; 39: .... reported by the family at accessible clinic or mobile points. A history and .... service delivery; (ii) disability prevention must be a high priority because ...

Open hemorrhoidectomy versus stapler hemorrhoidopexy: A prospective study

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Mumtaz Din Wani

2017-06-01

Conclusion: The use of a circular stapler in the treatment of hemorrhoids is safe, effective, causes minimal pain and is associated with fewer complications than conventional hemorrhoidectomy. [Arch Clin Exp Surg 2017; 6(2.000: 66-73

Disease: H00382 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available Lundstrom JO ... TITLE ... Mosquito-borne viruses in western Europe: a review. ... JOURNAL ... J Vector Ecol 24:1-... fever: an epidemiological review of a re-emerging infectious disease. ... JOURNAL ... Clin Infect Dis 49:942-8

Untitled

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2004-07-02

Jul 2, 2004 ... Jimma, Ethiopia. Department of Pediatrics and Child Health, Jimma University, P.O. Box 378, Jimma, Ethiopia .... were taken filled into a prepared ..... This study was financial granted by the ... evaluation of new agents. Clin.

Enhancement of Human Cheek Skin Texture by Acacia Nilotica Bark ...

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HP

Keywords: Acacia nilotica, Cream, Visioscan VC 98, Skin texture, Anti-aging. Tropical Journal of .... volunteer (A) before and (B) after application of extract cream for 3 months The .... Antioxidants and vitamins in Cosmetics. Clin. Dermatol. 2001 ...

Disease: H01798 [KEGG MEDICUS

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Full Text Available H01798 Autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV) Autos...omal dominant neovascular inflammatory vitreoretinopathy (ADNIV) is an inherited autoimmune uveitis and vitr... ... Secondary glaucoma in CAPN5-associated neovascular inflammatory vitreoretinopathy. ... JOURNAL ... Clin Ophtha

Preoperative Platelettolymphocyte Ratio as a Prognostic Factor in ...

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2018-02-07

Feb 7, 2018 ... 2018 Nigerian Journal of Clinical Practice | Published by Wolters Kluwer ‑ Medknow. How to cite this ... factor in geriatric patients with proximal femoral fractures. Niger J Clin .... examinations that show blood contents in depth.

Intraocular Pressure in Pregnant and Non-Pregnant Nigerian Women

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Erah

. ... ocular diseases and these were used as the exclusion ... between groups with student's t-test. ... SD = standard deviation, SEM = standard error of mean, N= .... 38(4):229-34. 26. Qureshi IA. Intraocular pressure and pregnancy. Clin. Med.

Work-based assessment: A critical element of specialist medical ...

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and decision-making under compulsory supervision in real life. In some of our training ... serious concerns about the utility of WBA for high-stakes summative assessment purposes .... blocks for theory development. Best Pract Res Clin Obstet ...

Cancer de la prostate et leucémie lymphoïde chronique

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shanker

. Other malignancies in chronic lymphocy- tic leukemia/small lymphocytic lymphoma. J Clin Oncol 2009;27: 904–10. [7] Schollkopf C, Rosendahl D, Rostgaard K, Pipper C, Hjalgrim H. Risk of second cancer after chronic lymphocytic leukemia.

Fertility Preservation for Children Diagnosed with Cancer

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Full Text Available ... for patients with cancer: American Society of Clinical Oncology clinical practice guideline update . J Clin Oncol. 2013; ... Incorporating fertility preservation into the care of young oncology patients. Cancer. 2010;117:4-10. Download Patient ...

International Journal of Agriculture and Rural Development ...

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Articles must be typed on A4 paper, double-spaced and with at least 3 cm margins on the top and bottom, while the left and right margins would be 4 cm each. Full length papers including tables and ... James, U.K. (1998). A selective index for measuring early maturing rates in West African Dwarf goats. Int. J. Agric. R. Dev.

The Autism Diagnostic Observation Schedule--Toddler Module: A New Module of a Standardized Diagnostic Measure for Autism Spectrum Disorders

Science.gov (United States)

Luyster, Rhiannon; Gotham, Katherine; Guthrie, Whitney; Coffing, Mia; Petrak, Rachel; Pierce, Karen; Bishop, Somer; Esler, Amy; Hus, Vanessa; Oti, Rosalind; Richler, Jennifer; Risi, Susan; Lord, Catherine

2009-01-01

The Autism Diagnostic Observation Schedule (ADOS; Lord et al., J Autism Dev Disord, 30(3):205-223, 2000) is widely accepted as a "gold standard" diagnostic instrument, but it is of restricted utility with very young children. The purpose of the current project was to modify the ADOS for use in children under 30 months of age. A modified ADOS, the…

Cryostratigraphy and sedimentology of high-Arctic fjord-valleys

OpenAIRE

Gilbert, Graham Lewis

2018-01-01

Fjord-valleys, as sediment-filled palaeofjords, are characteristic of formerly glaciated mountainous coastal areas. High-Arctic fjord-valleys commonly host permafrost, but are poorly accessible and hence have drawn relatively little research. The research presented in this thesis combines the methods of cryostratigraphy, clastic sedimentology, sequence stratigraphy, geomorphology and geochronology to investigate the sedimentary infilling, permafrost formation and late Quaternary landscape dev...

Psychosocial Factors Associated with Resilience and Perceived Readiness Among Navy Corpsmen

Science.gov (United States)

2016-08-15

2010; 71(7): 823– 30. 7. Pietrzak RH, Johnson DC, Goldstein MB, Malley JC, Southwick SM: Psychological resilience and postdeployment social...organizational commitment, which refers to an individual’s psychological attachment to the organization. Organizational commitment is predictive of...functioning. Child Dev 2003; 74(3): 769–82. 15. Bandura A: Social foundations of thought and action: a social cognitive theory. Englewood

78 FR 32214 - Land Acquisitions: Appeals of Land Acquisition Decisions

Science.gov (United States)

2013-05-29

...; 134D0102DR-DS5A300000-DR.5A311.IA000113; Docket ID: BIA-2013-0005] RIN 1076-AF15 Land Acquisitions: Appeals... trust under this part, including broadening notice of any right to file an administrative appeal. DATES... the United States acquired title. See, e.g., Neighbors for Rational Dev., Inc. v. Norton, 379 F.3d 956...

The Dalit Women's Movement in India

OpenAIRE

Anandi Collective

2009-01-01

The Anandi Collective describes the way feminists and Dalit leaders worked to build a movement of Dalit women. They describe the challenges and successes of the 1,600 Dalit women from a remote area in a very feudal part of India, who have set out to overcome deeply seated prejudices. Development (2009) 52, 208–214. doi:10.1057/dev.2009.21

Supplemental Grounding of Extended EMP Collectors.

Science.gov (United States)

1982-01-31

G52AAXEX40602 H2590D as Contract DNA 001-80-C-0294. The program was monitored by Major Blair Williams, RAEE . The work described in this report was...ATTN: RAEE ATTN: DPOPM-COM-W-D ATTN RAAE ATTN: NATA Deputy Chief of Staff for Rsch Dev & Acq 4 cy ATTN: TITL ATTN: DAMA-CSS-N Defense Tech Info Ctr

Smart Prosthetic Hand Technology - Phase 2

Science.gov (United States)

2011-05-01

functional magnetic resonance imaging (f- MRI ) was used to analyze the reciprocal adaptation between the human brain and the prosthetic hand by the...Schmidt PC. Influence of compacted hydrophobic and hydrophilic colloidal silicon dioxide on tableting properties of pharmaceutical excipients. Drug Dev...nanoparticles, and manganese nanoparticles) in magnetic resonance imaging ( MRI ) in the detection and staging of cancer [2]. 2.1 Iron Oxide

78 FR 77144 - Announcement of Funding Awards for Fiscal Year 2013 for the Housing Choice Voucher Program

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2013-12-20

..., HOPEWELL, VA 23860. VA: VIRGINIA HSG REDEV AUTH.. 601 SOUTH 0 9,400 BELVIDERE ST, RICHMOND, VA 23220. VT...: HENDERSON HA 111 SOUTH ADAMS 0 17,800 ST, HENDERSON, KY 42420. KY: CYNTHIANA HA 149 FEDERAL ST, 0 4,200... 20895. MI: MICHIGAN STATE HSG DEV PO BOX 30044, 0 84,800 AUTH. LANSING, MI 48909. MN: VIRGINIA HRA PO...

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I am a student enrolled in a master's program. ... I am required to complete an internship in an organization selected by my university. Can this ... Please note that you must meet all criteria and be able to work on a full-time basis. ... A free online course is offered by SciDev, and this checklist was developed as part of a project ...

Identification of Biomarkers for Endometriosis Using Clinical Proteomics

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Yang Zhao

2015-01-01

Full Text Available Background: We investigated possible biomarkers for endometriosis (EM using the ClinProt technique and proteomics methods. Methods: We enrolled 50 patients with EM, 34 with benign ovarian neoplasms and 40 healthy volunteers in this study. Serum proteomic spectra were generated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MS combined with weak cationic exchange (WCX magnetic beads. Possible biomarkers were analyzed by a random and repeat pattern model-validation method that we designed, and ClinProtools software, results were refined using online liquid chromatography-tandem MS. Results: We found a cluster of 5 peptides (4210, 5264, 2660, 5635, and 5904 Da, using 3 peptides (4210, 5904, 2660 Da to discriminate EM patients from healthy volunteers, with 96.67% sensitivity and 100% specificity. We selected 4210 and 5904 m/z, which differed most between patients with EM and controls, and identified them as fragments of ATP1B4, and the fibrinogen alpha (FGA isoform 1/2 of the FGA chain precursor, respectively. Conclusions: ClinProt can identify EM biomarkers, which - most notably - distinguish even early-stage or minimal disease. We found 5 stable peaks at 4210, 5264, 2660, 5635, and 5904 Da as potential EM biomarkers, the strongest of which were associated with ATP1B4 (4210 Da and FGA (5904 Da; this indicates that ATP1B4 and FGA are associated with EM pathogenesis.

Effects of aqueous extract of Basella alba leaves on haematological ...

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Jane

2010-09-02

Sep 2, 2010 ... It is high in vitamin A, vitamin C, vitamin B9 (folic acid), calcium ..... noids in serum of control and insulin dependent diabetic Spanish subjects. Clin. Chem. ... of serum glutamic oxaloacetic and glutamic pyruvic transaminases.

A study of the frequency of methylation of gene promoter regions in ...

Indian Academy of Sciences (India)

2013-04-02

Apr 2, 2013 ... colorectal cancer in the Taiwanese population. CHANG-CHIEH WU1 ... hypermethylation of promoter-region CpG islands is an important ... mismatch repair gene MLH1 plays an important role in dele- ..... Asia Pac. J. Clin.

Healthcare providers' attitudes and perceptions in infection ...

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Objectives: To assess the attitudes and perceptions of healthcare providers ... antibiotics and only 32% always send a sample for culture sensitivity ..... resistance - A global issue of concern. Asian J. Pharma Clin Res. 2009; 2(2): 34 - 39. 4.

PATTERNS OF SEVEN AND COMPLICATED MALARIA IN CHILDREN

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Association of Vogt Koyanagi Harada Syndrome and Seronegative ... HLA groups in Japan (3, 4). ... transferred through HL A-DQ and-DR alleles (6). ... that her maternal twin had psoriasis. .... Ophthalmol Clin North Am 15:333-41,2002. 12.

thirst perception in dehydrated sickle cell disease patients in steady

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Daniel Owu

Ingram, 1956). It is prevalent especially among people with ancestry in ..... thalassemia and sickle polymerization tendency on the urine concentrating defect of individual with sickle cell trait. J. Clin. Invest., 88: 1963-. 1968. Igbokwe, VU. and Obika ...

Initial Pseudomonas aeruginosa infection in patients with cystic fibrosis: characteristics of eradicated and persistent isolates

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Tramper-Stranders, G. A.; van der Ent, C. K.; Molin, Søren

2012-01-01

Clin Microbiol Infect 2012; 18: 567574 Abstract Despite intensive eradication therapy, some CF patients with early Pseudomonas aeruginosa infection rapidly develop a chronic infection. To elucidate factors associated with this persistence, bacterial characteristics of early P. aeruginosa isolates...

the effect of aqueous stem bark extract of erythrina mildbraedii

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USER

2015-06-01

Jun 1, 2015 ... cytochrome-P (CYP) 450 enzymes in both the liver and the kidneys. In renal tissues ..... A Colorimetric. Method for Determination of Serum Creatinine. J. Clin. .... Reaction for Determination of Ammonia.Anal. Chem.39:971-974.

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2014-11-19

Nov 19, 2014 ... tannins that provide the astringent taste to wine. The phenolic acid; gallic acid and monomers - catechin .... red blood cell and white blood cell counts were determined by a ..... recessive oculocutaneous type. Clin. Genet., 17: ...

Pattern of Mismatch Repair Protein loss and its clinicopathological ...

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in the USA with lifetime risk of about 4% and incidence of 40 per l00 000.1,2 Initially .... secondary antibody (Novolink, Maxpolymer detection system. 1250, Leica ..... immunohistochemistry testing: an audit and cost analysis. J Clin. Pathol.

Triceps skin fold thickness as a measure of body fat in Nigerian

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owner

2012-11-26

Nov 26, 2012 ... and body fat distribution.2,3 Skin fold thickness measure- ments are a well ... different recognized areas for the measurement of SFT, ..... 'western children.' These .... Asia Pacific J Clin ... sity in children and young people:.

Disease: H01057 [KEGG MEDICUS

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Full Text Available nv_factor) ... AUTHORS ... Rusnak JM, Lucey DR ... TITLE ... Clinical gnathostomiasis: case report and review of the English-language liter...ature. ... JOURNAL ... Clin Infect Dis 16:33-50 (1993) DOI:10.1093/clinids/16.1.33

Effect of Thiazolidinedione Amide on Insulin Resistance, C- reactive ...

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arterial endothelium and smooth muscle function prior to and after the treatment. Results: TZDA treatment caused a significant (p < 0.05) decrease in serum testosterone from 93.1 ± ..... growth factor-I. Clin Endocrinol 1989; 31: 757-763. 10.

Endoscopy services in KwaZulu-Natal Province, South Africa, are ...

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is based on the values and principles of primary healthcare, but major discrepancies ... To audit the GI endoscopy services in KZN and compare these with the current guidelines for ..... Quality assurance of endoscopy units. Best Pract Res Clin ...

Psychosocial Factors Predicting Severity of Depression Among ...

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2017-03-06

Mar 6, 2017 ... treatment-seeking HIV/AIDS patients: A multi-site Nigerian study. Niger J. Clin Pract 2017 .... the role played by self-esteem, HIV-related stigma, and anticipated ..... could serve as a measure of treatment adherence and help.

Can mushrooms fix atmospheric nitrogen?

Indian Academy of Sciences (India)

Unknown

Introduction. Rhizobium is a genus of symbiotic N2-fixing soil bacteria that induce ... To produce biofilm cultures, a 2 × 2 cm yeast manitol agar. (YMA) slab was .... determination of antibiotic susceptibilities of bacterial biofilms;. J. Clin. Microbiol.

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salah

Type two cell surface metaloprotein. (CD10) is a type II ... of antibodies to HCV in human serum. (ADALTIS ITALIA ..... matous germ cell tumors. Jpn. J. Clin. ... tiple steps in embryonic development and malignant transformation. Cell. 1998, 11 ...

El Centro de Cardioestimuladores del Uruguay. CCC Medical Devices

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Pablo Darscht

2011-05-01

Full Text Available Estudio de caso del Centro de Cardioestimuladores del Uruguay - CCC Medical Devices preparado a solicitud de Ingenio en el marco del proyecto financiado por la Iniciativa para Incubadoras de InfoDev - Grupo Banco Mundial. Este estudio detalla los pasos seguidos por una empresa nacional con un fuerte factor de innovación y los cambios producidos en el entorno de los negocios de la empresa. El comienzo de una pequeña empresa de marcapasos que tras pasar por diferentes etapas hoy gana mercados en el área de ingeniería para dispositivos médicos para diferentes empresas de investigación biomédica a nivel internacional.AbstractCase study of the Centro de Cardioestimuladores del Uruguay - CCC Medical Devices prepared on behalf of Ingenio within the project financed by de Incubator Initiative of InfoDev-World Bank Group. This study refers to the steps followed by a highly innovative local company and to the changes in its business environment. The start up of a small pacemakers company that after going through different stages is presently increasing its market share in the area of engineering of medical devices for biomedic research companies worldwide.

Measurement of $|V_{cb}|$, form factors and branching fractions in the decays $\\overline{B}^0 \\to D^{*+}l^- \\overline{\

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Buskulic, Damir; Décamp, D; Ghez, P; Goy, C; Lees, J P; Lucotte, A; Minard, M N; Nief, J Y; Odier, P; Pietrzyk, B; Casado, M P; Chmeissani, M; Comas, P; Crespo, J M; Delfino, M C; Efthymiopoulos, I; Fernández, E; Fernández-Bosman, M; Garrido, L; Juste, A; Martínez, M; Orteu, S; Padilla, C; Park, I C; Pascual, A; Perlas, J A; Riu, I; Sánchez, F; Teubert, F; Colaleo, A; Creanza, D; De Palma, M; Gelao, G; Girone, M; Iaselli, Giuseppe; Maggi, G; Maggi, M; Marinelli, N; Nuzzo, S; Ranieri, A; Raso, G; Ruggieri, F; Selvaggi, G; Silvestris, L; Tempesta, P; Tricomi, A; Zito, G; Huang, X; Lin, J; Ouyang, Q; Wang, T; Xie, Y; Xu, R; Xue, S; Zhang, J; Zhang, L; Zhao, W; Abbaneo, D; Alemany, R; Bazarko, A O; Bright-Thomas, P G; Cattaneo, M; Cerutti, F; Coyle, P; Drevermann, H; Forty, Roger W; Frank, M; Hagelberg, R; Harvey, J; Janot, P; Jost, B; Kneringer, E; Knobloch, J; Lehraus, Ivan; Lutters, G; Mato, P; Minten, Adolf G; Miquel, R; Mir, L M; Moneta, L; Oest, T; Pacheco, A; Pusztaszeri, J F; Ranjard, F; Rensing, P E; Rizzo, G; Rolandi, Luigi; Schlatter, W D; Schmelling, M; Schmitt, M; Schneider, O; Tejessy, W; Tomalin, I R; Venturi, A; Wachsmuth, H W; Wagner, A; Ajaltouni, Ziad J; Barrès, A; Boyer, C; Falvard, A; Gay, P; Guicheney, C; Henrard, P; Jousset, J; Michel, B; Monteil, S; Montret, J C; Pallin, D; Perret, P; Podlyski, F; Proriol, J; Rosnet, P; Rossignol, J M; Fearnley, Tom; Hansen, J B; Hansen, J D; Hansen, J R; Hansen, P H; Nilsson, B S; Rensch, B; Wäänänen, A; Kyriakis, A; Markou, C; Simopoulou, Errietta; Siotis, I; Vayaki, Anna; Zachariadou, K; Blondel, A; Bonneaud, G R; Brient, J C; Bourdon, P; Rougé, A; Rumpf, M; Valassi, Andrea; Verderi, M; Videau, H L; Candlin, D J; Parsons, M I; Focardi, E; Parrini, G; Corden, M; Georgiopoulos, C H; Jaffe, D E; Antonelli, A; Bencivenni, G; Bologna, G; Bossi, F; Campana, P; Capon, G; Casper, David William; Chiarella, V; Felici, G; Laurelli, P; Mannocchi, G; Murtas, F; Murtas, G P; Passalacqua, L; Pepé-Altarelli, M; Curtis, L; Dorris, S J; Halley, A W; Knowles, I G; Lynch, J G; O'Shea, V; Raine, C; Scarr, J M; Smith, K; Teixeira-Dias, P; Thompson, A S; Thomson, E; Thomson, F; Turnbull, R M; Becker, U; Geweniger, C; Graefe, G; Hanke, P; Hansper, G; Hepp, V; Kluge, E E; Putzer, A; Schmidt, M; Sommer, J; Tittel, K; Werner, S; Wunsch, M; Beuselinck, R; Binnie, David M; Cameron, W; Dornan, Peter J; Martin, E B; Moutoussi, A; Nash, J; Sedgbeer, J K; Stacey, A M; Williams, M D; Dissertori, G; Girtler, P; Kuhn, D; Rudolph, G; Betteridge, A P; Bowdery, C K; Colrain, P; Crawford, G; Finch, A J; Foster, F; Hughes, G; Sloan, Terence; Williams, M I; Galla, A; Giehl, I; Greene, A M; Hoffmann, C; Jakobs, K; Kleinknecht, K; Quast, G; Renk, B; Rohne, E; Sander, H G; Van Gemmeren, P; Zeitnitz, C; Aubert, Jean-Jacques; Bencheikh, A M; Benchouk, C; Bonissent, A; Bujosa, G; Calvet, D; Carr, J; Diaconu, C A; Etienne, F; Konstantinidis, N P; Payre, P; Rousseau, D; Talby, M; Sadouki, A; Thulasidas, M; Trabelsi, K; Aleppo, M; Ragusa, F; Berlich, R; Blum, Walter; Büscher, V; Dietl, H; Dydak, Friedrich; Ganis, G; Gotzhein, C; Kroha, H; Lütjens, G; Lutz, Gerhard; Männer, W; Moser, H G; Richter, R H; Rosado-Schlosser, A; Schael, S; Settles, Ronald; Seywerd, H C J; Saint-Denis, R; Stenzel, H; Wiedenmann, W; Wolf, G; Boucrot, J; Callot, O; Choi, Y; Cordier, A; Davier, M; Duflot, L; Grivaz, J F; Heusse, P; Höcker, A; Jacholkowska, A; Jacquet, M; Kim, D W; Le Diberder, F R; Lefrançois, J; Lutz, A M; Nikolic, I A; Park, H J; Schune, M H; Simion, S; Veillet, J J; Videau, I; Zerwas, D; Azzurri, P; Bagliesi, G; Batignani, G; Bettarini, S; Bozzi, C; Calderini, G; Carpinelli, M; Ciocci, M A; Ciulli, V; Dell'Orso, R; Fantechi, R; Ferrante, I; Foà, L; Forti, F; Giassi, A; Giorgi, M A; Gregorio, A; Ligabue, F; Lusiani, A; Marrocchesi, P S; Messineo, A; Palla, Fabrizio; Sanguinetti, G; Sciabà, A; Spagnolo, P; Steinberger, Jack; Tenchini, Roberto; Tonelli, G; Vannini, C; Verdini, P G; Blair, G A; Bryant, L M; Chambers, J T; Gao, Y; Green, M G; Medcalf, T; Perrodo, P; Strong, J A; Von Wimmersperg-Töller, J H; Botterill, David R; Clifft, R W; Edgecock, T R; Haywood, S; Maley, P; Norton, P R; Thompson, J C; Wright, A E; Bloch-Devaux, B; Colas, P; Emery, S; Kozanecki, Witold; Lançon, E; Lemaire, M C; Locci, E; Pérez, P; Rander, J; Renardy, J F; Roussarie, A; Schuller, J P; Schwindling, J; Trabelsi, A; Vallage, B; Black, S N; Dann, J H; Johnson, R P; Kim, H Y; Litke, A M; McNeil, M A; Taylor, G; Booth, C N; Boswell, R; Brew, C A J; Cartwright, S L; Combley, F; Köksal, A; Lehto, M H; Newton, W M; Reeve, J; Thompson, L F; Böhrer, A; Brandt, S; Cowan, G D; Grupen, Claus; Minguet-Rodríguez, J A; Rivera, F; Saraiva, P; Smolik, L; Stephan, F; Apollonio, M; Bosisio, L; Della Marina, R; Giannini, G; Gobbo, B; Musolino, G; Rothberg, J E; Wasserbaech, S R; Armstrong, S R; Elmer, P; Feng, Z; Ferguson, D P S; Gao, Y S; González, S; Grahl, J; Greening, T C; Hayes, O J; Hu, H; McNamara, P A; Nachtman, J M; Orejudos, W; Pan, Y B; Saadi, Y; Scott, I J; Walsh, A M; Walsh, J; Wu Sau Lan; Wu, X; Yamartino, J M; Zheng, M; Zobernig, G

1997-01-01

Two samples of exclusive semileptonic decays, 579 B0->D*+l-nu events and 261 B0->D+l-nu events, are selected from approximately 3.9 million hadronic Z decays collected by the ALEPH detector at LEP. From the reconstructed differential decay rate of each sample, the product of the hadronic form factor F(w) at zero recoil of the D(*)+ meson and the CKM matrix element |Vcb| are measured to be FD*+(1)|Vcb| = (31.9 +/- 1.8(stat) +/- 1.9(syst) ) Mail afs archive asis auth bin boot categ cern collab comments core date dev drdspool etc export external_repno filename ftp home kadb lib lost+found mail mbox mnt nfs nsr old_archive old_drdspool old_pub opt pages pcfs pub publi publitype reconfigure ref repno sbin share sys tit tmp usr var vmunix 10**-3, FD+(1)|Vcb| = (27.8 +/- 6.8(stat) +/- 6.5(syst) ) Mail afs archive asis auth bin boot categ cern collab comments core date dev drdspool etc export external_repno filename ftp home kadb lib lost+found mail mbox mnt nfs nsr old_archive old_drdspool old_pub opt pages pcfs pub...

DEP LA ATSVANH ET OUDETE ST AMENT IN DEV ER KOND IG IN ...

African Journals Online (AJOL)

Test

zeer begrijpelijk, dat men als Christelijk Oud-Testamenticus bij de. Joden beurtelings een .zekere geprikkeldheid en een nog moeilijker te dragen ironie ondervindt? Is het Oude Testament niet aan het Jodendom geschonken? On getwijfeld is de bedoeling van dit geschenk, als van alle genadegaven. Gods, deze geweest ...

Correlations between genetic variance and adiposity measures, and ...

Indian Academy of Sciences (India)

justed and adjusted for the covariates (P = 0.006 in adjusted model). In multiple logistic regression .... of the World Health Organization (WHO Expert Consul- tation 2004) and the ...... sity in urban Hanoi, Vietnam. Asia. Pac. J. Clin. Nutr. 18, 234 ...

Jokar et al., Afr J Tradit Complement Altern Med. (2016) 13(1):40-44 ...

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PROF ADEWUNMI

Jokar et al., Afr J Tradit Complement Altern Med. ... Shiraz- Iran.3Department of Obstetrics and Gynecology, School of Medicine and maternal- fetal ..... Ann Intern Med 2001; 135(5):344–51. 7. ... Clin Geriatr Med.2008; ... Indian J. Med Res.

CASE REPORT

African Journals Online (AJOL)

2011-09-02

10):690-697. 6. Tattevin P, Chevrier S, Gangneux J. Can we describe the epidemiolgy of candidemia without using selective blood culture bottles for fungus detection? Clin Infect Dis 2004;39:598-599. 7. Mess T, Daar E. Utility ...

A Case Report of Early Gastric Signet Ring Cell Carcinoma

African Journals Online (AJOL)

2018-02-07

gmail.com. How to cite this article: Akabah PS, Mocan S, Molnar C, Dobru D. Importance of optical diagnosis in early gastric cancer: A case report of early gastric signet ring cell carcinoma. Niger J Clin Pract 2017;20:1342-5.

Scientific Medical Journal: Submissions

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References in the text are to be arranged to the Harvard system. ... Studies delayed hypersensitivity in Hodgkin disease. J. Clin. Invest.; 41: 100 – 110. For books; Author's name, year of publication in brackets, title of the book, editions, ...

Disease: H00576 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available a deficiency of 2-laminin in the basement membrane. Developmental disorder; Kidn... AUTHORS ... Gubler MC ... TITLE ... Inherited diseases of the glomerular basement membrane. ... JOURNAL ... Nat Clin Pract Nephrol 4:24-37 (2008) DOI:10.1038/ncpneph0671 ...

Adverse cardiovascular effects of anabolic steroids : pathophysiology imaging

NARCIS (Netherlands)

Golestani, Reza; Slart, Riemer H. J. A.; Dullaart, Robin P. F.; Glaudemans, Andor W. J. M.; Zeebregts, Clark J.; Boersma, Hendrikus H.; Tio, Rene A.; Dierckx, Rudi A. J. O.

Eur J Clin Invest 2012; 42 (7): 795803 Abstract Background Anabolic-androgenic steroids (AAS) are widely abused for enhancing muscle mass, strength, growth and improving athletic performance. Materials and methods In recent years, many observational and interventional studies have shown important

Dexmedetomidine effect to lung injury in abdominal hypertension

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Ozlem Boybeyi and #775;

2016-06-01

Conclusion: IAP of 15 mmHg in rats causes mild injury in lung parenchyma. The administration of DEX in clinical doses does not seem to significantly affect the lungs of rats. [Arch Clin Exp Surg 2016; 5(2.000: 100-104

Reply to "Can the levels of Can f 1 in indoor environments be evaluated without considering passive transport of allergen indoors?"

NARCIS (Netherlands)

Krop, E.J.M.; Vredegoor, D.W.; Chapman, M.D.; Willemse, A.; Heederik, D.J.J.

2013-01-01

Response to Liccardi G, Salzillo A, Piccolo A, D’Amato M, D’Amato G. Can the levels of Can f 1 in indoor environments be evaluated without considering passive transport of allergen indoors? J Allergy Clin Immunol 2013;131:1258-9.

Solid pseudopapillary tumor of the pancreas: A population-based comparison with pancreatic ductal adenocarcinoma

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G. Paul Wright

2016-09-01

Conclusion: SPTP is a rare pancreatic neoplasm found more commonly in young women in the tail of the pancreas and is associated with a significantly more favorable prognosis than PDAC. [Arch Clin Exp Surg 2016; 5(3.000: 148-153

Decreasing candidaemia rate in abdominal surgery patients after introduction of fluconazole prophylaxis*

DEFF Research Database (Denmark)

Holzknecht, Barbara; Thorup, Jens Frederik; Arendrup, M C

2011-01-01

Clin Microbiol Infect ABSTRACT: Although abdominal surgery is an established risk factor for invasive candidiasis, the precise role of antifungal prophylaxis in these patients is not agreed upon. In 2007, fluconazole was added to the prophylactic antibiotic treatment for patients...

Prescription audit in a paediatric sickle cell clinic in South-West ...

African Journals Online (AJOL)

Miyakis S, Pefanis A, Tsakris A. The challenges of antimicrobial drug resistance in Greece. Clin Infect Dis 2011; 53(2): 177-84. 35.Dik JW, Vemer P, Friedrich AW, et al. Financial evaluations of antibiotic stewardship programs-a systematic review.

BKR 27(2) pp. 63-67 (Ejike et al)

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Femi J. Olorunniji

2015-06-30

Jun 30, 2015 ... (Ejike and Ezeanyika, 2008; Bastien et al., 2014). The body mass index (BMI) is the .... Mei Z, Grummer-Strawm LM, Pietrobelli A, Goulding A,. Goran MI, Dietz WH. ... Nutrition Examination Survey (1988-1994). Am J Clin Nutr;.

Studies on Zinc and Copper Ion in Relation to Wound Healing in ...

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olayemitoyin

and healthy West African dwarf (WAD) goats of both sexes fed with concentrate, grass, cassava peel and water ad ... The wound healed faster in female goat compared with the males. ..... Clin North Am 1996; 76:879 – 903. ... Farm Foxes Pol.

Poorly Responsive Celiac Disease

Science.gov (United States)

... Close Celiac Disease Understanding Celiac Disease What is Celiac Disease? Symptoms Screening and Diagnosis Treatment and Follow-Up Dermatitis ... Schuppan D, Kelly CP. Etiologies and predictors of diagnosis in nonresponsive celiac disease. Clin Gastroenterol Hepatol 2007; 5 : 445–50. Finding ...

The Role of Diffusion-Weighted Magnetic Resonance Imaging in the ...

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2018-02-23

Feb 23, 2018 ... Imaging in the Differential Diagnosis of Simple and Hydatid Cysts of the. Liver. Niger J Clin .... the ADC mapping, the size of the region of interest. (ROI) was chosen as .... from simple one. Financial support and sponsorship.

Lack of Effectiveness of the 23-Valent Polysaccharide Pneumococcal Vaccine in Reducing All-Cause Pneumonias Among Healthy Young Military Recruits: A Randomized, Double-Blind, Placebo-Controlled Trial

Science.gov (United States)

2015-01-08

outpatient disease s unknown and there are diagnostic difficulties in identifying S. neumoniae , these reports likely underestimate the true impact of...Outcome measures included S. pneumonia infections, any-cause neumonia , any-cause respiratory disease, recruit training clin- cal pneumonia (radiographically

Can A Traumatic Bladder Injury be Fatal: A Case Series of 8 Patients

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Suhail Yaqoob Hakim

2012-04-01

Conclusions: Early detection and early repair is the key to success in a bladder injury. Bilateral percutaneous nephrostomy and re-exploration with bladder drainage does not help once sepsis sets in. [Arch Clin Exp Surg 2012; 1(2.000: 102-104

Development of a Rapid Qualitative Assay for Determining Elevated Antibody Levels to Periodontopathic Organisms

Science.gov (United States)

1990-01-01

stemic antibody titers to ".actinomycetemcornitans, B.gingivalis, Cochracea, and Eubacterium saburreum either de(., cased or remained similar to...1984b) Serological identification of oral Bacteroides spp . by enzyme-linked immunosorbent assay. J. Clin. Microbiol. 19: 639-644. Ebersole, J.L

BDML Metadata: 427 [SSBD[Archive

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Full Text Available , S. (2005) Dev Cell 8, 765-775. CC BY-NC-SA 0.150 c620c3ca-1022-4214-b934-f324b2b...http://ssbd.qbic.riken.jp/data/pdpml/kimura2005.pdpml0.05.xml http://ssbd.qbic.riken.jp/search/c620c3ca-1022-4214-b934-f324b2bd4010/ ...

Learning AWS OpsWorks

CERN Document Server

Rosner, Todd

2013-01-01

A fast-paced, example-based guide to mastering AWS OpsWorks.This book is geared towards application developers, system administrators, DevOps, and anyone else interested in delivering applications while managing highly-scalable and automated infrastructures using push-button procedures. Some knowledge of what cloud computing is as well as some familiarity with Amazon Web Services is all you need as a precursor to reading this book.

Behaviour in an Organization

OpenAIRE

Klímová, Kateřina

2009-01-01

Diploma thesis "The behavior in the organization" at a practical level, integrates the knowledge of psychology, sociology and management. It explains bahavior of people in the organization, which seeks to use this knowledge for the benefit of the organizaton and its management. It focuses on individual differences among people in the organization, organizational culture, relationships between people in workplace, organizational structure, communication within the organization, motivation, dev...

Analüütilised voolud psühholoogias ja nende rakendamine pedagoogikas / Aleksander Elango

Index Scriptorium Estoniae

Elango, Aleksander, 1902-2004

2001-01-01

Analüütise psühholoogia kolm koolkonda - S.Freudì koolkond e. päris-psühhoanalüüs, A.Adlerì koolkond e. individuaalpsühholoogia ja C.G.Jungì psühhoanalüüsi ja individuaalpsühholoogia sünteesi luua püüdev koolkond. Analüütise psühholoogia koolkondade ja pedagoogika suhetest

Donor-akceptorové systémy jako materiály pro molekulární elektroniku

Czech Academy of Sciences Publication Activity Database

Dekoj, Václav; Bělohradský, Martin; Lipnická, Šárka; Starý, Ivo

2008-01-01

Roč. 102, č. 5 (2008), s. 369-369 ISSN 0009-2770. [Mezioborové setkání mladých biologů, biochemiků a chemiků. Konference Sigma-Aldrich /8./. 10.06.2008-13.06.2008, Devět skal - Žďárské vrchy] Institutional research plan: CEZ:AV0Z40550506 Keywords : oligophenylenacetylenes * TTF * molecular wires Subject RIV: CC - Organic Chemistry

Oligofenylenacetyleny nesoucí tetrathiafulvalenové jednotky jako materiály pro molekulární elektroniku

Czech Academy of Sciences Publication Activity Database

Dekoj, Václav; Bělohradský, Martin; Starý, Ivo

2009-01-01

Roč. 103, č. 5 (2009), s. 432-433 ISSN 0009-2770. [Mezioborové setkání mladých biologů, biochemiků a chemiků. Konference Sigma-Aldrich /9./. 26.05.2009-29.05.2009, Devět skal - Žďárské vrchy] Institutional research plan: CEZ:AV0Z40550506 Keywords : oligophenylacetylenes * tetrahiafulvalene * molecular electronics Subject RIV: CC - Organic Chemistry

Prazosin for Prophylaxis of Chronic Post Traumatic Headaches in OEF/OIF/OND Service Members and Veterans with Mild TBI

Science.gov (United States)

2017-10-01

mild traumatic brain injury, improved posttraumatic stress disorder severity and sleep correlated with symptomatic improvement. J Rehabil Res Dev...frequency and severity of headaches, in addition to decreasing PTSD-related symptoms and improving the quality of sleep . The objectives of this study...improving quality of sleep . The objectives of this study will be accomplished by conducting a randomized placebo-controlled double blind trial of prazosin

Identification of gene targets against dormant phase Mycobacterium tuberculosis infections

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Murphy Dennis J

2007-07-01

Full Text Available Abstract Background Mycobacterium tuberculosis, the causative agent of tuberculosis (TB, infects approximately 2 billion people worldwide and is the leading cause of mortality due to infectious disease. Current TB therapy involves a regimen of four antibiotics taken over a six month period. Patient compliance, cost of drugs and increasing incidence of drug resistant M. tuberculosis strains have added urgency to the development of novel TB therapies. Eradication of TB is affected by the ability of the bacterium to survive up to decades in a dormant state primarily in hypoxic granulomas in the lung and to cause recurrent infections. Methods The availability of M. tuberculosis genome-wide DNA microarrays has lead to the publication of several gene expression studies under simulated dormancy conditions. However, no single model best replicates the conditions of human pathogenicity. In order to identify novel TB drug targets, we performed a meta-analysis of multiple published datasets from gene expression DNA microarray experiments that modeled infection leading to and including the dormant state, along with data from genome-wide insertional mutagenesis that examined gene essentiality. Results Based on the analysis of these data sets following normalization, several genome wide trends were identified and used to guide the selection of targets for therapeutic development. The trends included the significant up-regulation of genes controlled by devR, down-regulation of protein and ATP synthesis, and the adaptation of two-carbon metabolism to the hypoxic and nutrient limited environment of the granuloma. Promising targets for drug discovery were several regulatory elements (devR/devS, relA, mprAB, enzymes involved in redox balance and respiration, sulfur transport and fixation, pantothenate, isoprene, and NAD biosynthesis. The advantages and liabilities of each target are discussed in the context of enzymology, bacterial pathways, target tractability

EVALUATION OF A NOVEL UAV-BORNE TOPO-BATHYMETRIC LASER PROFILER

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G. Mandlburger

2016-06-01

Full Text Available We present a novel topo-bathymetric laser profiler. The sensor system (RIEGL BathyCopter comprises a laser range finder, an Inertial Measurement Unit (IMU, a Global Navigation Satellite System (GNSS receiver, a control unit, and digital cameras mounted on an octocopter UAV (RiCOPTER. The range finder operates on the time-of-flight measurement principle and utilizes very short laser pulses (<1 ns in the green domain of the spectrum (λ=532 nm for measuring distances to both the water surface and the river bottom. For assessing the precision and accuracy of the system an experiment was carried out in October 2015 at a pre-alpine river (Pielach in Lower Austria. A 200 m longitudinal section and 12 river cross sections were measured with the BathyCopter sensor system at a flight altitude of 15-20 m above ground level and a measurement rate of 4 kHz. The 3D laser profiler points were compared with independent, quasi-simultaneous data acquisitions using (i the RIEGL VUX1-UAV lightweight topographic laser scanning system (bare earth, water surface and (ii terrestrial survey (river bed. Over bare earth the laser profiler heights have a std. dev. of 3 cm, the water surface height appears to be underestimated by 5 cm, and river bottom heights differ from the reference measurements by 10 cm with a std. dev. of 13 cm. When restricting the comparison to laser profiler bottom points and reference measurements with a lateral offset below 1 m, the values improve to 4 cm bias with a std. dev. of 6 cm. We report additionally on challenges in comparing UAV-borne to terrestrial profiles. Based on the accuracy and the small footprint (3.5 cm at the water surface we concluded that the acquired 3D points can potentially serve as input data (river bed geometry, grain roughness and validation data (water surface, water depth for hydrodynamic-numerical models.

Evaluation of radionuclide calibrator performance with Tc-99m and I-123 in nuclear medicine centers

International Nuclear Information System (INIS)

Ahn, Ji Young; Kim, Gwe Ya; Yang, Hyun Kyu; Lim, Chun Il; Lee, Hyun Koo; Kim, Byung Tae; Jeong, Hee Kyo

2004-01-01

To minimize unnecessary radiation dose to patients, it is important to ensure that the radiopharmaceutical administered is accurately measured. Tc-99m is one of the popular radionuclide used in nuclear medicine and I-123 is also used widely in nuclear medicine. To investigate the level of measurement performance and to provide the participants with a traceable standard to check and review their calibration factors for these particular radionuclides, Korean Food and Drug Administration (KFDA) as a national secondary standard dosimetry laboratory conducted comparison program for Tc-99m and I-123 in nuclear medicine centers. 72 nuclear medicine centers (78 calibrators) participated in the comparison program for Tc-99m in 2003 and 37 centers (41 calibrators) for I-123 in 2004. For a comparison, Tc-99m and I-123 were accurately sub-divided into a series of 4 ml aliquots in 10 ml P6 vial and delivered to participants. Participants were invited to assay their P6 vial in each of their radionuclide calibrators and to report their results directly to KFDA. For the evaluation of raionuclide, KFDA used NPL-CRC radionuclide calibrator that is traceable to NPL (National Physical Laboratory) primany standard. The difference between the value reported by the hospital (A h ospital) and of the KFDA (A k fda) is expressed as a percent deviation (DEV (%) = 100 (A h ospital - A k fda)/A k fda). If there were calibrators over 10 % deviations, those were checked again with the same procedure. In Tc-99m, 65% of the calibrators showed deviations within 5 % and 18 % were in the range of 5 % < | DEV | ≤10 %, and 17 % were over 10 % deviations. In I-123, 41 % of the calibrators were within ±5 % and 29 % were in the range of 5 % < | DEV | ≤10 % and 30 % were over 10 %. The results have shown that such comparisons are necessary to improve the accuracy of the measurement and to identify radionuclide calibrators that are malfunctioning

Automated patient and medication payment method for clinical trials

Directory of Open Access Journals (Sweden)

Yawn BP

2013-01-01

Full Text Available Barbara P Yawn,1 Suzanne Madison,1 Susan Bertram,1 Wilson D Pace,2 Anne Fuhlbrigge,3 Elliot Israel,3 Dawn Littlefield,1 Margary Kurland,1 Michael E Wechsler41Olmsted Medical Center, Department of Research, Rochester, MN, 2UCDHSC, Department of Family Medicine, University of Colorado Health Science Centre, Aurora, CO, 3Brigham and Women's Hospital, Pulmonary and Critical Care Division, Boston, MA, 4National Jewish Medical Center, Division of Pulmonology, Denver, CO, USABackground: Published reports and studies related to patient compensation for clinical trials focus primarily on the ethical issues related to appropriate amounts to reimburse for patient's time and risk burden. Little has been published regarding the method of payment for patient participation. As clinical trials move into widely dispersed community practices and more complex designs, the method of payment also becomes more complex. Here we review the decision process and payment method selected for a primary care-based randomized clinical trial of asthma management in Black Americans.Methods: The method selected is a credit card system designed specifically for clinical trials that allows both fixed and variable real-time payments. We operationalized the study design by providing each patient with two cards, one for reimbursement for study visits and one for payment of medication costs directly to the pharmacies.Results: Of the 1015 patients enrolled, only two refused use of the ClinCard, requesting cash payments for visits and only rarely a weekend or fill-in pharmacist refused to use the card system for payment directly to the pharmacy. Overall, the system has been well accepted by patients and local study teams. The ClinCard administrative system facilitates the fiscal accounting and medication adherence record-keeping by the central teams. Monthly fees are modest, and all 12 study institutional review boards approved use of the system without concern for patient

Invisalign® treatment in the anterior region: were the predicted tooth movements achieved?

Science.gov (United States)

Krieger, Elena; Seiferth, Jörg; Marinello, Ivana; Jung, Britta A; Wriedt, Susanne; Jacobs, Collin; Wehrbein, Heinrich

2012-09-01

Based on our previous pilot study, the objective of this extended study was to compare (a) casts to their corresponding digital ClinCheck® models at baseline and (b) the tooth movement achieved at the end of aligner therapy (Invisalign®) to the predicted movement in the anterior region. Pre- and post-treatment casts as well as initial and final ClinChecks® models of 50 patients (15-63 years of age) were analyzed. All patients were treated with Invisalign® (Align Technology, Santa Clara, CA, USA). Evaluated parameters were: upper/lower anterior arch length and intercanine distance, overjet, overbite, dental midline shift, and the irregularity index according to Little. The comparison achieved/predicted tooth movement was tested for equivalence [adjusted 98.57% confidence interval (- 1.00; + 1.00)]. Before treatment the anterior crowding, according to Little, was on average 5.39 mm (minimum 1.50 mm, maximum 14.50 mm) in the upper dentition and 5.96 mm (minimum 2.00 mm, maximum 11.50 mm) in the lower dentition. After treatment the values were reduced to 1.57 mm (minimum 0 mm, maximum 4.5 mm) in the maxilla and 0.82 mm (minimum 0 mm, maximum 2.50 mm) in the mandible. We found slight deviations between pretreatment casts and initialClinCheck® ranging on average from -0.08 mm (SD ± 0.29) for the overjet and up to -0.28 mm (SD ± 0.46) for the upper anterior arch length. The difference between achieved/predicted tooth movements ranged on average from 0.01 mm (SD ± 0.48) for the lower anterior arch length, up to 0.7 mm (SD ± 0.87) for the overbite. All parameters were significantly equivalent except for the overbite (-1.02; -0.39). Performed with aligners (Invisalign®), the resolvement of the partly severe anterior crowding was successfully accomplished. Resolving lower anterior crowding by protrusion of the anterior teeth (i.e., enlargement of the anterior arch length) seems well predictable. The initial ClinCheck® models provided high accuracy compared to the

[Report of the editors, 2013].

Science.gov (United States)

García Puig, J; Gaspar Alonso-Vega, G; Ríos Blanco, J J

2014-01-01

The editors of Revista Clínica Española(Rev Clin Esp) inform on their editorial activity during the last 12 months: (a) objectives and attainments, (b) editorial activity, and (c) objectives for 2014. In 2013 the most relevant modification concerning the editorial activity has been the translation into English of the 5 manuscripts with abstract contained in each issue (http://www.revclinesp.es/). From the first January to the 30th September 2013 we received 458 manuscripts (50.9 manuscripts per month), a similar figure to that obtained in 2012 (51.1 manuscripts per month). The acceptance rate of the 443 manuscripts whose editorial process has been concluded was 23.7% (originals, 11.8%). We asked for 253 revisions to 186 reviewers and we received 74.4% revisions in less than 2 weeks (10.9 days). The mean time to adopt an editorial decision for all manuscripts («accepted»/«rejected») has been 20,3 (half than in 2009). For «originals» this figure has dropped from 56.6 days in 2009 to 22.5 days in 2013. The mean time elapsed from manuscript reception to its on-line publication was 94.8 days in 2013 (110.5 in 2012 and 155.8 in 2011). In 2013 the collaboration with the working groups from the Internal Medicine Spanish Foundation has reported 17 published manuscripts. In 2013 we were informed that the Journal Citation Reports excluded Rev Clin Esp from its impact factor journal list due to its elevated self-citations. We have taken a number of actions to reduce self-citations and we expect to be a minority in 2014. Some other data concerning the editorial policy are encouraging. In this sense, manuscript citation to Rev Clin Esp published articles has seen a substantial increase from 19% in 2008 to 29% in 2012. We work to achieve the digitalization of Rev Clin Esp from 1940 to 1999 (the journal is already digitalized since 2000). The continuous renewal of the journal sections and the working groups collaboration are necessary elements to make our journal, each day

Spindle Cell Metaplastic Breast Cancer: Case Report

Directory of Open Access Journals (Sweden)

Dursun Ozgur Karakas

2013-08-01

Conclusion: Spindle cell metaplastic breast cancer must be considered in differential diagnosis of breast cancers, and preoperative immunohistochemical examination, including cytokeratin and vimentin, must be added to pathological examination in intervening cases. [Arch Clin Exp Surg 2013; 2(4.000: 259-262

Evaluation of Various Filling Techniques in Distal Canals of ...

African Journals Online (AJOL)

2017-03-06

Mar 6, 2017 ... How to cite this article: Dumani A, Yilmaz S, Yoldas O, Kuden C. Evaluation ... Niger J. Clin Pract 2017;20:307-12. This is an open access article distributed ... in oval-shaped distal canals of mandibular molars was inadequate.

to view fulltext PDF

Indian Academy of Sciences (India)

2012-01-08

Jan 8, 2012 ... College of Medicine, Taipei 100, Taiwan. *Corresponding author ..... Drugs Exp. Clin. Res. 30 27–33. Dolan PJ and Johnson GV 2010 A caspase cleaved form of tau is .... Int. J. Geriatr. Psychiatry. ... Ann. Neurol. 61 476–483.

Liver alanine aminotransferase, insulin resistance and endothelial dysfunction in normotriglyceridaemic subjects with type 2 diabetes mellitus

NARCIS (Netherlands)

Schindhelm, R.K.; Diamant, M.; Bakker, S.J.L.; Dijk, van R.A.; Scheffer, P.G.; Teerlink, T.; Kostense, P.J.; Heine, R.J.

2005-01-01

and -0.31 [-0.58 to -0.03] respectively). Conclusions In metabolically well-controlled patients with DM2, ALT levels are related to decreased insulin-sensitivity and an impaired conduit vessel vascular function. Eur J Clin Invest 2005; 35(6): 369 -374

Disease: H01399 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available ng laboratory contamination, there are only two clinical reports of B. thuringiensis infection. Both the cas...onkukian (serotype H34) superinfection: case report and experimental evidence of pathogenicity in immunosuppressed mice. ... JOURNAL ... J Clin Microbiol 36:2138-9 (1998)

Disease: H01360 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available rgic rhinitis: current options and future perspectives. ... JOURNAL ... Curr Opin Allergy Clin Immunol 14:168-76 (2014) DOI:10.1097/ACI.0000000000000043 ...5 ... PMID:24535140 (drug) ... AUTHORS ... Braido F, Arcadipane F, Marugo F, Hayashi M, Pawankar R ... TITLE ... Alle

Disease: H01634 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available :17956071 ... AUTHORS ... Ramakrishnan K, Salinas RC ... TITLE ... Peptic ulcer disease. ... JOURNAL ... Am Fam Phys...ician 76:1005-12 (2007) ... PMID:2892567 (drug) ... AUTHORS ... Weir DG ... TITLE ... Peptic ulceration. ... JOURNAL ... Br Med J (Clin Res Ed) 296:195-200 (1988)

Rates and determinants of peripartum and puerperal anemia in ...

African Journals Online (AJOL)

2015-12-11

Dec 11, 2015 ... The mean hemoglobin levels at term, 48 h, and 6 weeks postpartum were 11.1 .... Methods. The study took place in the University of Nigeria Teaching ..... Chinese women in a longitudinal study of maternal nutrition. Eur J Clin ...

Enhanced Healing of Segmental Bone Defects by Modulation of the Mechanical Environment

Science.gov (United States)

2013-10-01

Employment opportunities received based upon experience/ training supported by this award Partly based upon her research during the completion of...School, Coventry CV4 7AL, United Kingdom References 1. Stevenson S. Enhancement of fracture healing with autogenous and allogeneic bone grafts. Clin

Colectomy and immediate anastomosis versus on-table colonic lavage for the management of acutely obstructed left colon

Directory of Open Access Journals (Sweden)

Mohamed I Kassem

2017-09-01

Conclusions: In favorable situations, omission of on-table lavage may be preferred for immediate anastomosis in obstructed left colonic emergencies. The technique is reliable and well-tolerated with no additional morbidity or mortality. [Arch Clin Exp Surg 2017; 6(3.000: 138-148

The changing epidemiology of Staphylococcus aureus bloodstream infection

DEFF Research Database (Denmark)

Laupland, K.B.; Lyytikäinen, O.; Søgaard, Mette

2013-01-01

Clin Microbiol Infect ABSTRACT: Although the epidemiology of Staphylococcus aureus bloodstream infection (BSI) has been changing, international comparisons are lacking. We sought to determine the incidence of S. aureus BSI and assess trends over time and by region. Population-based surveillance w...

Gold Standard Tests

Science.gov (United States)

2001-06-01

a slow release caffeine . NATO - RTA - Electroencephal Clin Neurophysiol 1997;103:554- AMP Meeting, 29 Sep-3Oct 1997, Rotterdam. 62. 22. Pieron H...I1 yellow Miscellaneous Strychnine + Cannabis indica + Tobacco LI, LII + (amblyopia) Sildenafil citrate + LI, III blue, blue- flashing lights

Antiradical potential and antifungal activities of essential oils of the ...

African Journals Online (AJOL)

STORAGESEVER

2008-11-19

Nov 19, 2008 ... Excellent for health (much vitamin C) (Economos and. Clay, 1999), C. ... hair; it can be applied to the face like refreshing lotion and can also .... after loss of proton. .... D limonene, linalool and crude Citrus oils extracts. Vet. Clin.

Annals of African Surgery July 2011 07.12.2011.indd

African Journals Online (AJOL)

andrew

2011-07-30

Jul 30, 2011 ... Background: Dislocation is one of the most common complications after total hip arthroplasty. .... Stern, J. T., Pare, E. B. and Schwartz, J. M. New perspectives on muscle use ... Clin Orthop 2001; 393:163–167. 13. Stähelin T ...

Advancing the Science of Team Science

Science.gov (United States)

Falk‐Krzesinski, Holly J.; Börner, Katy; Contractor, Noshir; Fiore, Stephen M.; Hall, Kara L.; Keyton, Joann; Spring, Bonnie; Stokols, Daniel; Trochim, William; Uzzi, Brian

2010-01-01

Abstract The First Annual International Science of Team Science (SciTS) Conference was held in Chicago, IL April 22–24, 2010. This article presents a summary of the Conference proceedings. Clin Trans Sci 2010; Volume 3: 263–266. PMID:20973925

Disease: H00223 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available :12787534 ... AUTHORS ... Buchanan GS, Rodgers GM, Ware Branch D ... TITLE ... The inherited thrombophilias: genet...ics, epidemiology, and laboratory evaluation. ... JOURNAL ... Best Pract Res Clin Obstet Gynaecol 17:397-411 (2003) DOI:10.1016/S1521-6934(03)00010-5 ...

Research

African Journals Online (AJOL)

abp

2017-09-12

Sep 12, 2017 ... 5. Poirel L, Nordmann P. Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology. Clin Microbiol. Infect. 2006; 12(9): 826-36. PubMed | Google Scholar. 6. Gonzalez-Villoria AM, Valverde-Garduno V. Antibiotic-Resistant. Acinetobacter baumannii Increasing Success Remains a.

Implementation of proteomic biomarkers : Making it work

NARCIS (Netherlands)

Mischak, Harald; Ioannidis, John P. A.; Argiles, Angel; Attwood, Teresa K.; Bongcam-Rudloff, Erik; Broenstrup, Mark; Charonis, Aristidis; Chrousos, George P.; Delles, Christian; Dominiczak, Anna; Dylag, Tomasz; Ehrich, Jochen; Egido, Jesus; Findeisen, Peter; Jankowski, Joachim; Johnson, Robert W.; Julien, Bruce A.; Lankisch, Tim; Leung, Hing Y.; Maahs, David; Magni, Fulvio; Manns, Michael P.; Manolis, Efthymios; Mayer, Gert; Navis, Gerarda; Novak, Jan; Ortiz, Alberto; Persson, Frederik; Peter, Karlheinz; Riese, Hans H.; Rossing, Peter; Sattar, Naveed; Spasovski, Goce; Thongboonkerd, Visith; Vanholder, Raymond; Schanstra, Joost P.; Vlahou, Antonia

Eur J Clin Invest 2012; 42 (9): 10271036 Abstract While large numbers of proteomic biomarkers have been described, they are generally not implemented in medical practice. We have investigated the reasons for this shortcoming, focusing on hurdles downstream of biomarker verification, and describe

Reprint of: B cell elimination in systemic lupus erythematosus. Clin. Immunol. 146(2) 90-103.

Science.gov (United States)

Furtado, João; Isenberg, David A

2013-09-01

Systemic lupus erythematosus (SLE) is an autoimmune disorder with a worldwide distribution, potentially life-threatening with considerable morbidity. The elimination of pathogenic B cells has emerged as a rational therapeutic option. Many open label studies have reported encouraging results in which clinical and serological remission have invariably been described, often enabling the reduction of steroid and immunosuppressive treatment. However, the results from randomized controlled studies have been disappointing and several questions remain to be answered. In this review we will focus on results of B cell direct depletion in the treatment of patients with systemic lupus erythematosus. Crown Copyright © 2013. Published by Elsevier Inc. All rights reserved.

Émergence et déclin de la gouvernance démocratique en droit international

NARCIS (Netherlands)

d' Aspremont, J.

2009-01-01

This article argues that the years 1989-2010 can be hailed as an unprecedented epoch of international law during which domestic governance - understood here in a traditional way as the use of public authority at the domestic level through a central governmental authority - came to be regulated to an

PAEDIATRIC POSTERIOR FOSSA TUMORS: A CLIN ICO - PATHOLOGICAL STUDY I N A TERTIARY CARE HOSPITAL

Directory of Open Access Journals (Sweden)

Raja Sekhar Kennedy

2015-09-01

Full Text Available INTRODUCTION: Tumors of the Central Nervous S ystem , are the second commonest childhood tumors and are the most common solid paediatric tumors comprising 40% - 50% of all tumors . 1 2 Posterior fossa brain tumors are one of the most devastating forms of human illnesses wh ich are more common in children. AIMS AND OBJECTIVES : To study the incidence, clinicopathological features and management of paediatric posterior fossa tumors. MATERIALS AND METHOD S : This is a prospective study done in the Department of Neurosurgery, Ranga raya Medical College, Government General Hospital, Kakinada from 2012 to 2015. It is a Tertiary Care Hospital. A total of 25 paediatric patients ranging from infants to 15 years were included in the study. DISCUSSION AND CONCL USION: Posterior fossa tumors are the commonest solid brain tumors of children with a rate of 2.4 per lakh of children at risk per year. The predominant symptoms are headache and vomiting followed by cerebellar symptoms (gait disturbances. Posterior fossa tumors are predominantly seen in children with peak incidence in first decade. Commonest presenting symptoms are due to raised intracranial pressure with headache and vomiting followed by cerebellar symptoms. Meticulous microsurgical techniques are to be followed in removing these tum ors. The incidence of recurrence is very less after gross total excision. Prognosis is good in patients with total excision

Improving performance of natural language processing part-of-speech tagging on clinical narratives through domain adaptation.

Science.gov (United States)

Ferraro, Jeffrey P; Daumé, Hal; Duvall, Scott L; Chapman, Wendy W; Harkema, Henk; Haug, Peter J

2013-01-01

Natural language processing (NLP) tasks are commonly decomposed into subtasks, chained together to form processing pipelines. The residual error produced in these subtasks propagates, adversely affecting the end objectives. Limited availability of annotated clinical data remains a barrier to reaching state-of-the-art operating characteristics using statistically based NLP tools in the clinical domain. Here we explore the unique linguistic constructions of clinical texts and demonstrate the loss in operating characteristics when out-of-the-box part-of-speech (POS) tagging tools are applied to the clinical domain. We test a domain adaptation approach integrating a novel lexical-generation probability rule used in a transformation-based learner to boost POS performance on clinical narratives. Two target corpora from independent healthcare institutions were constructed from high frequency clinical narratives. Four leading POS taggers with their out-of-the-box models trained from general English and biomedical abstracts were evaluated against these clinical corpora. A high performing domain adaptation method, Easy Adapt, was compared to our newly proposed method ClinAdapt. The evaluated POS taggers drop in accuracy by 8.5-15% when tested on clinical narratives. The highest performing tagger reports an accuracy of 88.6%. Domain adaptation with Easy Adapt reports accuracies of 88.3-91.0% on clinical texts. ClinAdapt reports 93.2-93.9%. ClinAdapt successfully boosts POS tagging performance through domain adaptation requiring a modest amount of annotated clinical data. Improving the performance of critical NLP subtasks is expected to reduce pipeline error propagation leading to better overall results on complex processing tasks.

The relationship between rumination, PTSD, and depression symptoms.

Science.gov (United States)

Roley, Michelle E; Claycomb, Meredith A; Contractor, Ateka A; Dranger, Paula; Armour, Cherie; Elhai, Jon D

2015-07-15

Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) are highly comorbid (Elhai et al., 2008. J. Clin. Psychiatry, 69, (4), 597-602). Rumination is a cognitive mechanism found to exacerbate and maintain both PTSD and MDD (Elwood et al., 2009. Clin. Psychol. Rev. 29, (1), 87-100; Olatunji et al., 2013. Clin. Psychol.: Sci. Pract. 20, (3), 225-257). Assess whether four rumination subtypes moderate the relationship between comorbid PTSD and MDD symptoms. We consecutively sampled patients (N=45) presenting to a mental health clinic using self-report measures of PTSD and MDD symptoms, and rumination in a cross-sectional design. Repetitive rumination moderates the relationship between PTSD and MDD symptoms at one standard deviation above the mean (β=.044, p=.016), while anticipatory rumination moderates the relationship between PTSD and MDD symptoms at mean levels and higher levels of anticipatory rumination (mean β=.030, p=.042; higher β=.060, p=.008). Repetitive and anticipatory rumination should be assessed in the context of comorbid PTSD and MDD and interventions should focus on reducing these rumination subtypes. Results should be replicated with other trauma populations because the number and complexity of traumatic events may impact the assessed symptoms. Constructs should also be assessed longitudinally, in order to establish causality. We are unable to confirm why rumination styles moderated the relationship between PTSD and depression or why counterfactual thinking and problem-focused thinking did not moderate the relationship between the two constructs. Copyright © 2015 Elsevier B.V. All rights reserved.

Treatment outcome of immediate, early and conventional single-tooth implants in the aesthetic zone : a systematic review to survival, bone level, soft-tissue, aesthetics and patient satisfaction

NARCIS (Netherlands)

den Hartog, Laurens; Huddleston Slater, James J. R.; Vissink, Arjan; Meijer, Henny J. A.; Raghoebar, Gerry M.

2008-01-01

den Hartog L, Huddleston Slater JJR, Vissink A, Meijer HJA, Raghoebar GM. Treatment outcome of immediate, early and conventional single-tooth implants in the aesthetic zone: a systematic review to survival, bone level, soft-tissue, aesthetics and patient satisfaction. J Clin Periodontol 2008; 35:

2361-IJBCS-Article-Asma Saihia

African Journals Online (AJOL)

hp

Effects of Ethanol on the fertility of adult male rabbit Oryctolagus cuniculus. ABSTRACT. Chronic ethanol consumption is associated with reproductive disorders in humans. Therefore, the ... All rights reserved. Keywords: Alcohol, epididymis, spermatozoa, testis, testosterone. ..... of alcohol. Clin. Liver Dis., 9(1): 673–702.

Body fat distribution in perinatally HIV-infected and HIV-exposed but uninfected children in the era of highly active antiretroviral therapy: outcomes from the Pediatric HIV/AIDS Cohort Study

Science.gov (United States)

Associations between abnormal body fat distribution and clinical variables are poorly understood in pediatric HIV disease. Our objective was to compare total body fat and its distribution in perinatally HIV-infected and HIV-exposed but uninfected (HEU) children and to evaluate associations with clin...

Genetics Home Reference: chronic myeloid leukemia

Science.gov (United States)

... Central Quintás-Cardama A, Cortes JE. Chronic myeloid leukemia: diagnosis and treatment. Mayo Clin Proc. 2006 Jul;81(7):973-88. Review. Citation on PubMed Skorski T. Genetic mechanisms of chronic myeloid leukemia blastic transformation. Curr Hematol Malig Rep. 2012 Jun; ...

CHAPTER 1

African Journals Online (AJOL)

Dr Olaleye

treatment of gastroenteritis, enteric fever, uretritis, and wound infections associated with the test bacteria. REFERENCES. Adaramoye OA, VO Nwaneri , KC Anyanwu , EO. Farombi and GO Emerole (2005). Possible anti- atherogenic effect of kolaviron (a Garcinia kola seed extract) in hypercholesterolaemic rats. Clin Exp ...

Mortality prediction in chronic obstructive pulmonary disease comparing the GOLD 2007 and 2011 staging systems

DEFF Research Database (Denmark)

Soriano, Joan B; Lamprecht, Bernd; Ramírez, Ana S

2015-01-01

BACKGROUND: There is no universal consensus on the best staging system for chronic obstructive pulmonary disease (COPD). Although documents (eg, the Global Initiative for Chronic Obstructive Lung Disease [GOLD] 2007) have traditionally used forced expiratory volume in 1 s (FEV1) for staging, clin...

Disease: H01021 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available , Blots S, Vogelaers D ... TITLE ... Invasive infection with Rhodococcus equi--two case reports and review of ... ... TITLE ... Severe Rhodococcus equi pneumonia: case report and literature review. ... JOURNAL ... Eur J Clin Microbiol Infect Dis 10:762-8 (1991) DOI:10.1007/BF01972506

Protein a Immunoadsorption May Hamper the Decision to Transplant Due to Interference With CDC Crossmatch Results

DEFF Research Database (Denmark)

Koefoed-Nielsen, Pernille; Bistrup, Claus; Christiansen, Mette

2017-01-01

using a highly sensitive time-resolved fluorescent assay. In conclusion, the results emphasize the importance of carefully considering CDC crossmatch results subsequent to IA, before a planned transplantation is either postponed or cancelled. J. Clin. Apheresis 32:163-169, 2017. © 2016 Wiley Periodicals...

Do clinicians use more question marks?

NARCIS (Netherlands)

Zijlmans, Maeike; Otte, Willem M; Van't Klooster, Maryse A; van Diessen, Eric; Leijten, Frans Ss; Sander, Josemir W

2015-01-01

OBJECTIVE: To quantify the use of question marks in titles of published studies. DESIGN AND SETTING: Literature review. PARTICIPANTS: All Pubmed publications between 1 January 2013 and 31 December 2013 with an available abstract. Papers were classified as being clinical when the search terms clin*,

64 original article optimization of rna extraction in mycobacterium

African Journals Online (AJOL)

Dr Oboro VO

... on thick 7H10 agar plates supplemented with 10% oleic acid- ... RNA lysis solution (0.15 M sucrose, 10 mM sodium acetate [pH 5.2] .... medium was discarded and the infected macrophage ..... Clin Invest 1995, 96(1):245-249. 18. Buchmeier ...

Predictive Factors for Mortality and Morbidity of Ruptured Abdominal Aortic Aneurysm Repair

Directory of Open Access Journals (Sweden)

Manabu Shiraishi

2012-04-01

Conclusions: Emergency open repair can be safely performed in patients for infrarenal rAAA. In particular, we identified specific independent predictive factors of clinical examination and laboratory studies for mortality, major morbidity and renal insufficiency. [Arch Clin Exp Surg 2012; 1(2.000: 94-101

The USAFSAM Cardiovascular Disease Followup Study: Clinical Evaluation of Subjects Near Age 43.

Science.gov (United States)

1982-08-01

SGOT Amador-Wacker (13), Worthington Diagnostics SGPT Henry et al. (14), Worthington Diagnostics GGTP Szasz (15), Worthington Diagnostics LDH Wacker...trans- aminase, and lactic acid dehydrogenase. Am J Clin Pathol 34:381-398 (1960). 15. Szasz , G. A kinetic photometric method for serum y-glutamyl

Genetics Home Reference: familial hemophagocytic lymphohistiocytosis

Science.gov (United States)

... lymphohistiocytosis. Haematologica. 2010 Apr;95(4):538-41. doi: 10.3324/haematol.2009.019562. Citation on PubMed ... Clin Immunol. 2011 Dec;11(6):512-6. doi: 10.1097/ACI.0b013e32834c22f5. Review. Citation on PubMed ...

Plasma Lp-PLA2 mass and apoB-lipoproteins that carry Lp-PLA2 decrease after sodium

NARCIS (Netherlands)

Constantinides, Alexander; Kerstens, Michiel N.; Dikkeschei, Bert D.; van Pelt, L. Joost; Tellis, Constantinos C.; Tselepis, Alexandros D.; Dullaart, Robin P. F.

2012-01-01

Eur J Clin Invest 2012; 42 (11): 12351243 Abstract Background Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a novel cardiovascular risk marker, which is predominantly complexed to apolipoprotein (apo) B-containing lipoproteins in human plasma. As increasing dietary sodium intake may decrease

Effect of Liraglutide on Ectopic Fat in Polycystic Ovary Syndrome: A Randomized Clinical Trial

DEFF Research Database (Denmark)

Frøssing, Signe; Nylander, Malin; Chabanova, Elizaveta

2018-01-01

Women with polycystic ovary syndrome (PCOS) were treated with the GLP-1 receptor agonist liraglutide to investigate the effect on liver fat content, visceral adipose tissue (VAT) and the prevalence of nonalcoholic fatty liver disease (NAFLD). In a double-blind, placebo-controlled, randomized clin...

A randomized trial evaluating a block-replacement regimen during radioiodine therapy

DEFF Research Database (Denmark)

Bonnema, Steen J; Grupe, Peter; Boel-Jørgensen, Henrik

2011-01-01

Eur J Clin Invest 2010 ABSTRACT: Background  Lack of consensus regarding the antithyroid drug regimen in relation to radioiodine ((131) I) therapy of hyperthyroidism prompted this randomized trial comparing two strategies. Design  Patients with Graves' disease (GD, n = 51) or toxic nodular goitre...

Serotonin Signal Transduction in Two Groups of Autistic Patients

Science.gov (United States)

2013-12-01

behavioral, and now molecular genetic evidence implicate dysfunction of the serotonin system in autism spectrum disorders (ASD), and specifically in...validationin individuals with autism spectrum disorders . 2007 J Autism Dev Disord . 37:855-66. Lord, C.L., Cook, E.H., Leventhal, B.L., Amaral, D.G...2000 Minireview: Autism spectrum disorders . Neuron.,28:355-363. Shao Y, Cuccaro ML, Hauser ER, Raiford KL, Menold MM, Wolpert CM, Ravan SA

Overcoming the Practical Barriers to Spinal Cord Cell Transplantation for ALS

Science.gov (United States)

2015-12-01

induced pluripotent stem cells from pig somatic cells . (2009) Proc Natl Acad Sci U S A. 106:10993-10998. 8. Feldman EL, Boulis NM, Hur J...Stice SL. Porcine Induced Pluripotent Stem Cells Produce Chimeric Offspring. (2010) Stem Cells Dev. 19(8):1211- 20. 12 LIST OF PERSONNEL RECEIVING PAY...straightforward delivery method and is achieved by directly injecting the spinal cord using a cannula.14,15 Stem cells and derived

2011 Agile (Scrum) Workshop Held in Baltimore, Maryland on November 14-15, 2011

Science.gov (United States)

2011-11-15

ment melded with CMMI Level 3 discipline. Her programs put the end-user in control of priorities and delivered capabilities re- sulting in a...OPS PEX Team: Internal •Devs/ SMEs /Testers •Architecture Committee •Etc. none Future implementation, not Current release Big R/Little r I n...Refine Pre-release Planning Release Planning Release Execution Post- release POT: ( SMEs and Developers) •Based on Approved Roadmap •Decomposes

Cardiovascular dysfunction in obesity and new diagnostic imaging techniques: the role of noninvasive image methods

OpenAIRE

Barbosa, Jose Augusto; Rodrigues,Alexandre; Mota,Cleonice; Barbosa,M M; Simoes-e-Silva,Ana

2011-01-01

José Augusto A Barbosa¹, Alexandre B Rodrigues¹, Cleonice Carvalho C Mota¹, Márcia M Barbosa², Ana C Simões e Silva¹¹Department of Pediatrics, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil; ²Ecocenter, Socor Hospital, Belo Horizonte, Minas Gerais, BrazilAbstract: Obesity is a major public health problem affecting adults and children in both dev...

Organizace embryí ve shlucích raných somatických embryí smrku ztepilého (Picea abies/L./Karst.)

Czech Academy of Sciences Publication Activity Database

Petřek, J.; Havel, L.; Víteček, J.; Vlašínová, H.; Adam, V.; Babula, P.; Bartušek, Karel; Potěšil, D.; Kizek, R.

2005-01-01

Roč. 99, č. 5 (2005), s. 377-378 ISSN 0009-2770. [Mezioborové setkání mladých biologů, biochemiků a chemiků /5./. 15.06.2005-18.06.2005, Devět skal - Žďárské vrchy] R&D Projects: GA AV ČR(CZ) IAA2065201 Keywords : somatic embrya * explantate cultivation * Picea abies Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering

Conceptual Modeling of a Quantum Key Distribution Simulation Framework Using the Discrete Event System Specification

Science.gov (United States)

2014-09-18

researcher discovered issues that affected the research. The most important of 19 these was the lack of advanced math functions in the DEVS- JAVA ...to install a comparative JAVA -language scientific library. This issue was reported to RTSync, but there was no fix to this issue during the research...and tracking systems necessary to deal with high relative angular motion. random motion of the platforms. and atmospheric turbulence that would be

Mentorat par les pairs de journalistes scientifiques dans les pays en ...

International Development Research Centre (IDRC) Digital Library (Canada)

Ce n'est pas d'hier que le CRDI appuie l'avancement du journalisme scientifique dans le Tiers-Monde. Depuis 2000, le CRDI a aidé à mettre en place le Réseau Sciences et Développement (SciDev.Net). Ce réseau, établi à Londres, exploite des noeuds régionaux dans les pays en développement; il a joué un rôle de ...

Centrosome-Based Mechanisms, Prognostics and Therapeutics in Prostate Cancer

Science.gov (United States)

2006-12-01

Roberts, J. M. CDK inhibitors: positive and negative regulators of G1- phase progression. Genes Dev. 13, 1501–1512 (1999). 20. La Terra , S. et al. The...centrosome matura - tion because disruption of the tubulin–pericentrin inter- action disrupts spindle pole assembly and possibly centrosome maturation...monitoring. We favor a model in which the check- point senses spindle pole assembly/centrosome matura - tion because disruption of the tubulin

Involvement of Human Estrogen Related Receptor Alpha 1 (hERR 1) in Breast Cancer and Hormonally Insensitive Disease

Science.gov (United States)

2000-08-01

SV40 early-to-late switch involves titration of cellular transcriptional repressors, Genes Dev. 7: 2206-19, 1993. 6. Bonnelye, E., Vanacker , J. M ...transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene, Mol Cell Biol. 17: 5400-9, 1997. 8. Vanacker , J. M ., Bonnelye, E...related receptor-alpha), Mol Endocrinol. 13: 764-73, 1999. 9. Vanacker , J. M ., Pettersson, K., Gustafsson, J. A., and Laudet, V. Transcriptional

Standard Port-Visit Cost Forecasting Model for U.S. Navy Husbanding Contracts

Science.gov (United States)

2009-12-01

Protocol (HTTP) server.35 2. MySQL . An open-source database.36 3. PHP . A common scripting language used for Web development.37 E. IMPLEMENTATION OF...Inc. (2009). MySQL Community Server (Version 5.1) [Software]. Available from http://dev.mysql.com/downloads/ 37 The PHP Group (2009). PHP (Version...Logistics Services MySQL My Structured Query Language NAVSUP Navy Supply Systems Command NC Non-Contract Items NPS Naval Postgraduate

Pengembangan Perangkat Pembelajaran Matematika Berbasis Konstruktivisme untuk Melatih Kemampuanberpikir Kritis Siswa SMA Kelas X

OpenAIRE

Rusiyanti, Rini Herlina

2011-01-01

Teaching learning process in math hasn't been requiring student to construct their knowledge and to exercise their critical thinking. So need to develop constructivism instruction materials for exercise student's ability in critical thinking. This research aim to: (1) Produce the valid and practice constructivism instruction materials to exercise student's ability in critical learning, (2) Know effectiveness it to exercise student's ability in critical learning. Instruction materials were dev...

DEVSML 2.0: The Language and the Stack

Science.gov (United States)

2012-03-01

problems outside it. For example, HTML for web pages, Verilog and VHDL for hardware description, etc. are DSLs for very specific domains. A DSL can be...Engineering ( MDE ) paradigm where meta-modeling allows such transformations. The metamodeling approach to Model Integrated Computing (MIC) brings...University of Arizona, 2007 [5] Mittal, S, Martin, JLR, Zeigler, BP, "DEVS-Based Web Services for Net-centric T&E", Summer Computer Simulation

Mastering Apache Cassandra

CERN Document Server

Neeraj, Nishant

2013-01-01

Mastering Apache Cassandra is a practical, hands-on guide with step-by-step instructions. The smooth and easy tutorial approach focuses on showing people how to utilize Cassandra to its full potential.This book is aimed at intermediate Cassandra users. It is best suited for startups where developers have to wear multiple hats: programmer, DevOps, release manager, convincing clients, and handling failures. No prior knowledge of Cassandra is required.

Reproduction, Embryonic Development, and Maternal Transfer of Contaminants in the Amphibian Gastrophryne carolinensis

OpenAIRE

Hopkins, William Alexander; DuRant, Sarah Elizabeth; Staub, Brandon Patrick; Rowe, Christopher Lee; Jackson, Brian Phillip

2005-01-01

Although many amphibian populations around the world are declining at alarming rates, the cause of most declines remains unknown. Environmental contamination is one of several factors implicated in declines and may have particularly important effects on sensitive developmental stages. Despite the severe effects of maternal transfer of contaminants on early development in other vertebrate lineages, no studies have examined the effects of maternal transfer of contaminants on reproduction or dev...