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Sample records for clic pets structure

  1. CLIC Drive Beam Accelerating Structures

    CERN Document Server

    Wegner, Rolf

    2012-01-01

    Travelling structures for accelerating the high-current (4.2 A) CLIC Drive Beam to an energy of 2.37 GeV are presented. The structures are optimised for efficiency (full beam loading operation) and a desired filling time. Higher order modes are studied and are reduced by detuning along the structure and by damping with silicon carbide loads.

  2. Development and testing of a double length pets for the CLIC experimental area

    Energy Technology Data Exchange (ETDEWEB)

    Sánchez, L., E-mail: laura.sanchez@ciemat.es [Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Avda. Complutense 40, 28040 Madrid (Spain); Carrillo, D.; Gavela, D.; Lara, A.; Rodríguez, E.; Gutiérrez, J.L; Calero, J.; Toral, F. [Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Avda. Complutense 40, 28040 Madrid (Spain); Samoshkin, A.; Gudkov, D.; Riddone, G. [European Organization for Nuclear Research (CERN), CH-1211, Geneva 23 (Switzerland)

    2014-05-11

    CLIC (compact linear collider) is a future e+e{sup −} collider based on normal-conducting technology, currently under study at CERN. Its design is based on a novel two-beam acceleration scheme. The main beam gets RF power extracted from a drive beam through power extraction and transfer structures (PETS). The technical feasibility of CLIC is currently being proved by its Third Test Facility (CTF3) which includes the CLIC experimental area (CLEX). Two Double Length CLIC PETS will be installed in CLEX to validate their performance with beam. This paper is focused on the engineering design, fabrication and validation of this PETS first prototype. The design consists of eight identical bars, separated by radial slots in which damping material is located to absorb transverse wakefields, and two compact couplers placed at both ends of the bars to extract the generated power. The PETS bars are housed inside a vacuum tank designed to make the PETS as compact as possible. Several joint techniques such as vacuum brazing, electron beam and arc welding were used to complete the assembly. Finally, several tests such as dimensional control and leak testing were carried out to validate design and fabrication methods. In addition, RF measurements at low power were made to study frequency tuning.

  3. Development and testing of a double length pets for the CLIC experimental area

    CERN Document Server

    Sánchez, L; Gavela, D; Lara, A; Rodríguez, E; Gutiérrez, J L; Calero, J; Toral, F; Samoshkin, A; Gudkov, D; Riddone, G

    2014-01-01

    CLIC (compact linear collider) is a future e þ e collider based on normal-conducting technology, currently under study at CERN. Its design is based on a novel two-beam acceleration scheme. The main beam gets RF power extracted from a drive beam through power extraction and transfer structures (PETS). The technical feasibility of CLIC is currently being proved by its Third Test Facility (CTF3) which includes the CLIC experimental area (CLEX). Two Double Length CLIC PETS will be installed in CLEX to validate their performance with beam. This paper is focused on the engineering design, fabrication and validation of this PETS fi rst prototype. The design consists of eight identical bars, separated by radial slots in which damping material is located to absorb transverse wake fi elds, and two compact couplers placed at both ends of the bars to extract the generated power. The PETS bars are housed inside a vacuum tank designed to make the PETS as compact as possible. Several joint techniques such as vacuum brazing...

  4. High power operation with beam of a CLIC pets equipped with on/off mechanism

    CERN Document Server

    Syratchev, I; Dubrovskiy, A; Skowronski, P; Ruber, R

    2012-01-01

    One of the feasibility issues of the CLIC two-beam scheme, is the possibility of rapidly switching off the rf power production in an individual Power Extraction and Transfer Structures (PETS) in case of breakdowns, either in the PETS or one of the main beam accelerating structures. The proposed solution is to use a variable external reflector connected to the PETS. When activated, this scheme allows us to gradually manipulate the rf power transfer to the accelerating structure and to reduce the rf power production in the PETS itself by a factor of 4. Recently the first operation of the Two Beam Test Stand (TBTS) PETS equipped with an ON/OFF mechanism was performed in CTF3. In this paper we will present the results of the PETS operation when powered by the drive beam up to high peak power levels (>100 MW) and compare them to expectations.

  5. Theoretical temperature model with experimental validation for CLIC Accelerating Structures

    CERN Document Server

    Aasly, Sara Hegdahl; Vamvakas, Alex; Alme, Johan; Haustveit, Svein

    Micron level stability of the Compact Linear Collider (CLIC) components is one of the main requirements to meet the luminosity goal for the future $48 \\,km$ long underground linear accelerator. The radio frequency (RF) power used for beam acceleration causes heat generation within the aligned structures, resulting in mechanical movements and structural deformations. A dedicated control of the air- and water- cooling system in the tunnel is therefore crucial to improve alignment accuracy. This thesis investigates the thermo-mechanical behavior of the CLIC Accelerating Structure (AS). In CLIC, the AS must be aligned to a precision of $10\\,\\mu m$. The thesis shows that a relatively simple theoretical model can be used within reasonable accuracy to predict the temperature response of an AS as a function of the applied RF power. During failure scenarios or maintenance interventions, the RF power is turned off resulting in no heat dissipation and decrease in the overall temperature of the components. The theoretica...

  6. CLIC OVERVIEW

    CERN Document Server

    Tomas, R

    2009-01-01

    The CLIC study is exploring the scheme for an electronpositron collider with a centre-of-mass energy of 3 TeV in order to make the multi-TeV range accessible for lepton physics. The current goal of the project is to demonstrate the feasibility of the technology by the year 2010. Recently, important progress has been made concerning the high-gradient accelerating structure tests and the experiments with beam in the CLIC test facility, CTF3. On the organizational side, the CLIC international collaborations have significantly gained momentum considerably boosting the CLIC study.

  7. CLIC Overview

    CERN Document Server

    Tomás, R

    2010-01-01

    The CLIC study is exploring the scheme for an electronpositron collider with a centre-of-mass energy of 3 TeV in order to make the multi-TeV range accessible for lepton physics. The current goal of the project is to demonstrate the feasibility of the technology by the year 2010. Recently, important progress has been made concerning the high-gradient accelerating structure tests and the experiments with beam in the CLIC test facility, CTF3. On the organizational side, the CLIC international collaborations have significantly gained momentum considerably boosting the CLIC study.

  8. The 30 GHz transfer structure for the CLIC study

    CERN Document Server

    Carron, G; Thorndahl, L

    1998-01-01

    In the so-called "Two-Beam Acceleration Scheme" the energy of a drive beam is converted to rf power by means of a "Transfer Structure", which plays the role of power source. In the Transfer Structure the bunched drive beam is decelerated by the electromagnetic field which it induces and builds up by the coherent interaction of successive bunches with the chosen longitudinal mode. The CLIC Transfer Structure is original in that it operates at 30 GHz and uses teeth-like corrugations to slow down the hybrid TM mode to make it synchronous with the drive beam. The beam energy is transformed into rf power, which travels along the structure and is collected by the output couplers. The 30 GHz rf power is then transported by means of two waveguides to two main linac disk-loaded accelerating structures. This report describes the CLIC Transfer Structure design, 3-D computer simulations, model construction and measure-ments as well as the prototype construction and testing with the low energy beam in the CLIC Test Facili...

  9. A Newly Designed and Optimized CLIC Main Linac Accelerating Structure

    CERN Document Server

    Grudiev, A

    2004-01-01

    A new CLIC main-linac accelerating-structure design, HDS (Hybrid Damped Structure), with improved high-gradient performance, efficiency and simplicity of fabrication is presented. The gains are achieved in part through a new cell design which includes fully-profiled rf surfaces optimized to minimize surface fields and hybrid damping using both iris slots and radial waveguides. The slotted irises allow a simple structure fabrication in quadrants with no rf currents across joints. Further gains are achieved through a new structure optimization procedure, which simultaneously balances surface fields, power flow, short and long-range transverse wakefields, rf-to-beam efficiency and the ratio of luminosity to input power. The optimization of a 30 GHz structure with a loaded accelerating gradient of 150 MV/m results in a bunch spacing of seven rf cycles and 32 % rf-to-beam efficiency.

  10. Vacuum arc localization in CLIC prototype radio frequency accelerating structures

    CERN Document Server

    AUTHOR|(CDS)2091976; Koivunen, Visa

    2016-04-04

    A future linear collider capable of reaching TeV collision energies should support accelerating gradients beyond 100 MV/m. At such high fields, the occurrence of vacuum arcs have to be mitigated through conditioning, during which an accelerating structure’s resilience against breakdowns is slowly increased through repeated radio frequency pulsing. Conditioning is very time and resource consuming, which is why developing more efficient procedures is desirable. At CERN, conditioning related research is conducted at the CLIC high-power X-band test stands. Breakdown localization is an important diagnostic tool of accelerating structure tests. Abnormal position distributions highlight issues in structure design, manufacturing or operation and may consequently help improve these processes. Additionally, positioning can provide insight into the physics of vacuum arcs. In this work, two established positioning methods based on the time-difference-ofarrival of radio frequency waves are extended. The first method i...

  11. Thermal joining studies of CLIC accelerating structures and Establishment of a test bench and studies of thermomechanical behaviour of a CLIC two beam module

    CERN Document Server

    Rossi, Fabrizio

    2013-01-01

    The assembly procedure of the CLIC accelerating structures is constituted of several steps, involving ultra-precision machining, heating cycles at very high temperatures and many quality controls necessary to fulfil the very tight technical requirements. Diverse issues are related to the diffusion bonding process of CLIC accelerating structures; due to diffusion creep mechanisms occurring at high temperature and low stress, residual deformations might be present at the end of the joining process. A theoretical and experimental approach is presented here in order to understand this issue further and feedback on the design process. As a second issue tackled here, the final alignment of CLIC is also affected by the power dissipation occurring in the module during the normal operation modes and resulting in time-varying non-uniform thermal fields. The thermo-mechanical models of CLIC two-beam modules developed in the past are then useful to predict the structural deformations affecting the final alignment of the ...

  12. CLIC Drive Beam Phase Stabilisation

    CERN Document Server

    Gerbershagen, Alexander; Schulte, Daniel

    The thesis presents phase stability studies for the Compact Linear Collider (CLIC) and focuses in particular on CLIC Drive Beam longitudinal phase stabilisation. This topic constitutes one of the main feasibility challenges for CLIC construction and is an essential component of the current CLIC stabilisation campaign. The studies are divided into two large interrelated sections: the simulation studies for the CLIC Drive Beam stability, and measurements, data analysis and simulations of the CLIC Test Facility (CTF3) Drive Beam phase errors. A dedicated software tool has been developed for a step-by-step analysis of the error propagation through the CLIC Drive Beam. It uses realistic RF potential and beam loading amplitude functions for the Drive and Main Beam accelerating structures, complete models of the recombination scheme and compressor chicane as well as of further CLIC Drive Beam modules. The tool has been tested extensively and its functionality has been verified. The phase error propagation at CLIC h...

  13. Experimental study of DC vacuum breakdown and application to high-gradient accelerating structures for CLIC

    CERN Document Server

    Shipman, Nicholas; Jones, Roger

    2016-01-01

    The compact linear collider (CLIC) is a leading candidate for the next generation high energy linear collider. As any breakdown would result in a partial or full loss of luminosity for the pulse in which it occurs, obtaining a low breakdown rate in CLIC accelerating structures is a critical requirement for the successful operation of the proposed collider. This thesis presents investigations into the breakdown phenomenon primarily in the low breakdown rate regime of interest to CLIC, performed using the CERN DC spark systems between 2011 and 2014. The design, construction and commissioning of several new pieces of hardware, as well as the development of improved techniques to measuring the inter-electrode gap distance are detailed. These hardware improvements were fundamental in enabling the exciting new experiments mentioned below, which in turn have provided significant additional insight into the phenomenon of breakdown. Experiments were performed to measure fundamental parameters of individual breakdowns...

  14. Finite Element Model for Thermal-Structural analysis of CLIC Lab Module type 0#2

    CERN Document Server

    Moilanen, Antti; Vamvakas, Alex; Vainola, Jukka Ilmari; Doebert, Steffen

    2017-01-01

    Temperature changes lead to unwanted thermo-mechanical deformations in the components of the Compact Linear Collider (CLIC) module. There are several sources and sinks of heat around the CLIC two-beam module. Heat is generated in the components that produce, transfer, and extract radio frequency (RF) power. Excess heat is removed from the components by cooling water as well as dissipated to air by convection from the outer surfaces of the components. The ambient temperature might also vary along the tunnel during the operation of CLIC. Due to tight assembling and alignment tolerances, it is necessary to minimize the thermo-mechanical deformations in the components. In this paper, the steps of thermal-structural Finite Element Analysis (FEA) of CLIC lab module type 0#2 are described from geometry model simplification to setting up the simulation. The description is accompanied by useful hints for CATIA and ANSYS users performing similar modelling tasks. A reliable computer simulation is important for studying ...

  15. Design of a 3 GHz Accelerator Structure for the CLIC Test Facility (CTF 3) Drive Beam

    CERN Document Server

    Carron, G; Luong, M; Millich, Antonio; Rugo, E; Syratchev, I V; Thorndahl, L

    2000-01-01

    For the CLIC two-beam scheme, a high-current, long-pulse drive beam is required for RF power generation. Taking advantage of the 3 GHz klystrons available at the LEP injector once LEP stops, a 180 MeV electron accelerator is being constructed for a nominal beam current of 3.5 A and 1.5 ms pulse length. The high current requires highly effective suppression of dipolar wakes. Two concepts are investigated for the accelerating structure design: the "Tapered Damped Structure" developed for the CLIC main beam, and the "Slotted Iris - Constant Aperture" structure. Both use 4 SiC loads per cell for effective higher-order mode damping. A full-size prototype of the TDS structure has been built and tested successfully at full power. A first prototype of the SICA structure is being built

  16. Material studies in the frame of CLIC Accelerating structures production conducted within the Mechanics program together with Metso Oy

    CERN Document Server

    Nurminen, Janne

    2012-01-01

    MeChanICs (Marie Curie Linking Industry to CERN) is an Industry to Academia Partnership and Pathways (IAPP) platform for precision manufacturing knowledge exchange bringing together five Finnish manufacturing companies with Helsinki Insitute of Physics (HIP) and CERN. The scientific objective of MeChanICs project is to contribute to the manufacturing RTD of CLIC enabling technologies. The focus is on the design, materials, machining, brazing and assembly of A CLIC accelerating structure. This study deals with the materials work package of the program and wants to explore the following items: 1) producing copper accelerating structures for CLIC from raw copper powder by near net shape hot isostatic pressing (HIP). 2) The feasibility to use HIP diffusion bonding of the accelerator structures as a function of surface quality and applied temperature and pressure. 3) Brazing for CLIC AS auxiliary systems, like water cooling or damping manifolds, to the disc stack by coating one of the brazing partners with an enab...

  17. A high phase advance damped and detuned structure for the main linacs of CLIC

    CERN Document Server

    Khan, Vasim; Jones, Roger M; Wuensch, Walter; Grudiev, A

    2010-01-01

    The main accelerating structures for the CLIC are designed to operate at an average accelerating gradient of 100 MV/m. The accelerating frequency has been optimised to 11.994 GHz with a phase advance of 2π/3 [1] of the main accelerating mode. The moderately damped and detuned structure (DDS) design [2-3] is being studied as an alternative to the strongly damped WDS design [1]. Both these designs are based on the nominal accelerating phase advance. Here we explore high phase advance (HPA) structures in which the group velocity of the rf fields is reduced compared to that of standard (2π/3) structures. The electrical breakdown strongly depends on the fundamental mode group velocity. Hence it is expected that electrical breakdown is less likely to occur in the HPA structures. We report on a study of both the fundamental and dipole modes in a CLIC_DDS_ HPA structure, designed to operate at 5π/6 phase advance per cell. Higher order dipole modes in both the standard and HPA structures are also studied.

  18. The CLIC feasibility demonstration in CTF3

    CERN Document Server

    Skowroński, P K; Bettoni, S; Constance, B; Corsini, R; Divall Csatari, M; Dabrowski, A E; Doebert, S; Dubrovskiy, A; Kononenko, O; Olvegaard, M; Persson, T; Rabiller, A; Tecker, F; Farabolini, W; Lillestol, R L; Adli, E; Palaia, A; Ruber, R

    2011-01-01

    The objective of the CLIC Test Facility CTF3 is to demonstrate the feasibility issues of the CLIC two-beam technology: the efficient generation of a very high current drive beam, used as the power source to accelerate the main beam to multi-TeV energies with gradients of over 100 MeV/m, and stable drive beam deceleration. Results of successful beam acceleration with over 100 MeV/m energy gain are shown. Measurements of drive beam deceleration over a chain of Power Extraction Structures (PETS) are presented. The achieved RF power levels, the stability of the power production and of the deceleration are discussed. Finally, we give an overview of the remaining issues to be addressed by the end of 2011.

  19. Assembly Test of Elastic Averaging Technique to Improve Mechanical Alignment for Accelerating Structure Assemblies in CLIC

    CERN Document Server

    Huopana, J

    2010-01-01

    The CLIC (Compact LInear Collider) is being studied at CERN as a potential multi-TeV e+e- collider [1]. The manufacturing and assembly tolerances for the required RF-components are important for the final efficiency and for the operation of CLIC. The proper function of an accelerating structure is very sensitive to errors in shape and location of the accelerating cavity. This causes considerable issues in the field of mechanical design and manufacturing. Currently the design of the accelerating structures is a disk design. Alternatively it is possible to create the accelerating assembly from quadrants, which favour the mass manufacturing. The functional shape inside of the accelerating structure remains the same and a single assembly uses less parts. The alignment of these quadrants has been previously made kinematic by using steel pins or spheres to align the pieces together. This method proved to be a quite tedious and time consuming method of assembly. To limit the number of different error sources, a meth...

  20. Studies on high-precision machining and assembly of CLIC RF structures

    CERN Document Server

    Huopana, J; Riddone, G; Österberg, K

    2010-01-01

    The Compact Linear Collider (CLIC) is currently under development at CERN as a potential multi-TeV e+e– collider. The manufacturing and assembly tolerances for the required RF components are essential for the final efficiency and for the operation of CLIC. The proper function of an accelerating structure is sensitive to mechanical errors in the shape and the alignment of the accelerating cavity. The current tolerances are in the micron range. This raises challenges in the field of mechanical design and demands special manufacturing technologies and processes. Currently the mechanical design of the accelerating structures is based on a disk design. Alternatively, it is possible to create the accelerating assembly from quadrants, which has the potential to be favoured for the mass production due to simplicity and cost. In this case, the functional shape inside of the accelerating structure remains the same and a single assembly uses less parts. This paper focuses on the development work done in design and sim...

  1. High-Gradient test results from a CLIC prototype accelerating structure : TD26CC

    CERN Document Server

    Degiovanni, A; Farabolini, W; Grudiev, A; Kovermann, J; Montessinos, E; Riddone, G; Syratchev, I; Wegner, R; Wuensch, W; Solodko, A; Woolley, B

    2014-01-01

    The CLIC study has progressively tested prototype accelerating structures which incorporate an ever increasing number of features which are needed for a final version ready to be installed in a linear collider. The most recent high power test made in the CERN X-band test stand, Xbox-1, is of a CERN-built prototype which includes damping features but also compact input and output power couplers, which maximize the overall length to active gradient ratio of the structure. The structure’s high-gradient performance, 105 MV/m at 250 ns pulse length and low breakdown rate, matches previously tested structures validating both CERN fabrication and the compact coupler design.

  2. CLIC accelerator modules under construction at CERN

    CERN Multimedia

    Anna Pantelia

    2012-01-01

    The Compact LInear Collider (CLIC) study is dedicated to the design of an electron-positron (e- e+) linear accelerator, colliding particle beams at the energy of 3 TeV. The CLIC required luminosity can be reached with powerful particle beams (14 MW each) colliding with extremely small dimensions and high beam stability at the interaction point. The accelerated particle beams must have dimensions of 45 nm in the horizontal plane and 1 nm in the vertical plane. CLIC relies upon a novel two-beam acceleration concept in which the Radio Frequency (RF) power is extracted from a low energy but high-intensity particle beam, called Drive Beam (DB), and transferred to a parallel high energy accelerating particle beam, called Main Beam (MB). The extraction and transfer of the RF power is achieved by the Power Extraction and Transfer Structures (PETS) and the particle beam acceleration is achieved with high precision RF-Accelerating Structures (AS), operating at 11.9942 GHz with an accelerating gradient of 100 MV/m, whi...

  3. Development of an X-Band Dielectric-Based Wakefield Power Extractor for Potential CLIC Applications

    CERN Document Server

    Jing, C -J; Kanareykin, A; Schoessow, P; Conde, M E; Gai, W; Power, J G; Syratchev, I

    2011-01-01

    In the past decade, tremendous efforts have been put into the development of the CLIC Power Extraction and Transfer Structure (PETS), and significant progress has been made. However, one concern remains the manufacturing cost of the PETS, particularly considering the quantities needed for a TeV machine. A dielectric-based wakefield power extractor in principle is much cheaper to build. A low surface electric field to gradient ratio is another big advantage of the dielectric-loaded accelerating/decelerating structure. We are currently investigating the possibility of using a cost-effective dielectric-based wakefield power extractor as an alternative to the CLIC PETS. We designed a 12 GHz dielectric-based power extractor which has a similar performance to CLIC PETS with parameters 23 mm beam channel, 240 ns pulse duration, 135 MW output per structure using the CLIC drive beam. In order to study potential rf breakdown issues, as a first step we are building a 11.424 GHz dielectric-based power extractor scaled fr...

  4. CLIC Test Facility 3

    CERN Multimedia

    Kossyvakis, I; Faus-golfe, A

    2007-01-01

    The design of CLIC is based on a two-beam scheme, where short pulses of high power 30 GHz RF are extracted from a drive beam running parallel to the main beam. The 3rd generation CLIC Test Facility (CTF3) will demonstrate the generation of the drive beam with the appropriate time structure, the extraction of 30 GHz RF power from this beam, as well as acceleration of a probe beam with 30 GHz RF cavities. The project makes maximum use of existing equipment and infrastructure of the LPI complex, which became available after the closure of LEP.

  5. Test facility for investigation of heating of 30 GHz accelerating structure imitator for the CLIC project

    CERN Document Server

    Elzhov, A V; Kaminsky, A K; Kuzikov, S V; Perelshtejn, E A; Peskov, N Yu; Petelin, M I; Sedykh, S N; Sergeev, A P; Sergeev, A S; Syratchev, I V; Zaitsev, N I

    2004-01-01

    Since 2001 an experimental test facility for investigation of lifetime of a copper material, with respect to multiple RF pulse actions, was set up on the basis of the JINR (Dubna) FEM oscillator, in collaboration with IAP RAS (Nizhny Novgorod). A high-Q copper cavity, which simulates the parameters of the accelerating structure of the collider CLIC at an operating frequency of 30GHz, is used in the investigation. The experimental setup consists of a wavebeam injector - FEM oscillator (power of similar to 25MW, pulse duration up to 200ns, spectral bandwidth not higher than 0.1%), a quasi-optic two-mirror transmission line, a wave-type converter, and a testing cavity. The frequency and transmission features of the components of the quasi-optic line were analyzed.

  6. High Power RF Induced Thermal Fatigue in the High Gradient CLIC Accelerating Structures

    CERN Document Server

    Arnau-Izquierdo, G; Heikkinen, S; Neupert, N; Wuensch, W

    2007-01-01

    The need for high accelerating gradients for the CLIC (Compact Linear Collider) imposes considerable constraints on the materials of the accelerating structures. The surfaces exposed to high pulsed RF (Radio Frequency) currents are subjected to cyclic thermal stresses possibly resulting in surface break up by fatigue. Various high strength alloys from the group of high conductivity copper alloys have been selected and have been tested in different states, with different surface treatments and in different stress ratios. Low to medium cycle fatigue data (up to 108 cycles) of fully compressive surface thermal stresses has been collected by means of a pulsed laser surface heating apparatus. The surface damage has been characterized by SEM observations and roughness measurements. High cycle fatigue data, up to 7x1010 cycles, of varying stress ratio has been collected in high frequency bulk fatigue tests using an ultrasonic apparatus. Up-to-date results from these experiments are presented.

  7. The CLIC Vertex Detector

    CERN Document Server

    Dannheim, D

    2015-01-01

    The precision physics needs at TeV-scale linear electron-positron colliders (ILC and CLIC) require a vertex-detector system with excellent flavour-tagging capabilities through a meas- urement of displaced vertices. This is essential, for example, for an explicit measurement of the Higgs decays to pairs of b-quarks, c-quarks and gluons. Efficient identification of top quarks in the decay t → W b will give access to the ttH-coupling measurement. In addition to those requirements driven by physics arguments, the CLIC bunch structure calls for hit tim- ing at the few-ns level. As a result, the CLIC vertex-detector system needs to have excellent spatial resolution, full geometrical coverage extending to low polar angles, extremely low material budget, low occupancy facilitated by time-tagging, and sufficient heat removal from sensors and readout. These considerations challenge current technological limits. A detector concept based on hybrid pixel-detector technology is under development for the CLIC ver- tex det...

  8. Optimum frequency and gradient for the CLIC main linac accelerating structure

    CERN Document Server

    Grudiev, A; Wuensch, Walter

    2006-01-01

    A novel procedure for the optimization of CLIC main linac parameters including operating frequency and the accelerating gradient is presented. The optimization procedure takes into account both beam dynamics and high power rf constraints. Beam dynamics constraints are given by emittance growth due to short- and long-range transverse wakefields. RF constraints are given by rf breakdown and pulsed surface heating limitations of the accelerating structure. Interpolation of beam and structure parameters in a wide range allows hundreds of millions of accelerating structures to be analyzed to find the structure with the highest ratio of luminosity to main linac input power, which is used as the figure of merit. The frequency and gradient have been varied in the ranges 12-30 GHz and 90-150 MV/m respectively. It is shown that the optimum frequency lies in the range from 16 to 20 GHz depending on the accelerating gradient and that the optimum gradient is below 100 MV/m. Based on our current understanding of the constr...

  9. Physics and Detectors at CLIC

    CERN Document Server

    CERN. Geneva

    2012-01-01

    CLIC represents an attractive option for the future particle physics programme at the energy frontier. CLIC is a proposed electron-positron linear collider, based on a novel two beam accelerating structure, with the capability of operating at centre-of-mass energies of up to 3 TeV. The Physics and Detector volume of the CLIC conceptual design report was recently published as a CERN yellow report. In this seminar, I will review the conclusions of this report, focussing on four main areas. Firstly, I will give an overview of the physics potential at CLIC, and will place this in the context of a possible scenario for the staged construction of the machine. Secondly, I will discuss the challenges for a detector operating in the CLIC machine environment. I will then present detailed studies of possible detector concepts, based on high granularity particle flow calorimetry, which demonstrate that the required detector performance goals at CLIC can be met. Finally, I will highlight the main issues for the future R&a...

  10. CLIC Brochure

    CERN Multimedia

    AUTHOR|(CDS)2086185

    2015-01-01

    After the discovery of the Higgs boson and with upgrades to higher energy and luminosity, the LHC is mapping the route of particle physics into the future. The next step in this journey of discovery could be a linear electron-positron collider, which would complement the LHC and allow high precision measurements of the Higgs boson, the top quark and electroweak processes in addition to possible new physics beyond the Standard Model. The Compact Linear Collider is under development by two worldwide collaborations, pushing the limits of particle acceleration and detection. Technological R&D, physics simulations and engineering studies must all come together to make CLIC a reality.

  11. Beam Position Monitoring at CLIC

    CERN Document Server

    Prochnow, J

    2003-01-01

    At the European Organisation for Nuclear Research CERN in Geneva, Switzerland the design of the Compact LInear Collider (CLIC) for high energy physics is studied. To achieve the envisaged high luminosity the quadrupole magnets and radio-frequency accelerating structures have to be actively aligned with micron precision and submicron resolution. This will be done using beam-based algorithms which rely on beam position information inside of quadrupoles and accelerating structures. After a general introduction to the CLIC study and the alignment algorithms, the concept of the interaction between beams and radio-frequency structures is given. In the next chapter beam measurements and simulations are described which were done to study the performance of cavity beam position monitors (BPM). A BPM design is presented which is compatible with the multi-bunch operation at CLIC and could be used to align the quadrupoles. The beam position inside the accelerating structures will be measured by using the structures thems...

  12. Power production experiments at the Test Beam Line in the CLIC Test Facility 3

    CERN Document Server

    Lillestøl, Reidar Lunde; Adli, Erik; Lundheim, Lars Magne

    2010-01-01

    CLIC is an international study of a future multi-TeV electron-positron linear collider, where the energy of a high-intensity drive beam is extracted and transferred to the main beam via Power Extraction and Transfer Structures (PETS) in the form of rf power. The study of power production is therefore essential for the feasibility of CLIC. Power production in PETS has been studied, and ex- periments have been performed in the decelerator Test Beam Line in the CLIC Test Facility 3. In particular, the correlation of the power production and the beam position inside the structure has been studied. It is shown that the total produced power is constant when the beam has a position offset through the PETS. In addition, the difference between the measured phases from each side is independent of the beam position, which allows for efficient combination of the fields. However, the ratio of the power on each side of the PETS unexpectedly shows a linear dependence on the horizontal offset, with a correlation value of 0.8...

  13. TCAD simulations of High-Voltage-CMOS Pixel structures for the CLIC vertex detector

    CERN Document Server

    Buckland, Matthew Daniel

    2016-01-01

    The requirements for precision physics and the experimental conditions at CLIC result in stringent constraints for the vertex detector. Capacitively coupled active pixel sensors with 25 μm pitch implemented in a commercial 180 nm High-Voltage CMOS (HV-CMOS) process are currently under study as a candidate technology for the CLIC vertex detector. Laboratory calibration measurements and beam tests with prototypes are complemented by detailed TCAD and electronic circuit simulations, aiming for a comprehensive understanding of the signal formation in the HV-CMOS sensors and subsequent readout stages. In this note 2D and 3D TCAD simulation results of the prototype sensor, the Capacitively Coupled Pixel Detector version three (CCPDv3), will be presented. These include the electric field distribution, leakage current, well capacitance, transient response to minimum ionising particles and charge-collection.

  14. CLIC Physics Potential

    CERN Document Server

    Pandurovic, Mila

    2017-01-01

    The CLICdp is an international collaboration that investigates the physics potential of the Compact Linear Collider (CLIC) and performs research and development of the CLIC detector. CLIC is a future multi-TeV linear electron-positron collider, designed to cover a physics program of the Standard model physics, with the emphasis on Higgs and top as well as to address the wide range of open questions of the phenomena beyond the Standard model with high precision. The CLIC is designed to be build and operated at three discrete energy stages, sort(s) = 380 GeV, 1.5 and 3.0 TeV, which are optimized for the foreseen physics program. In this talk the CLIC accelerator, detector and experimental environment of CLIC will be presented, as well as, the number of the full-simulation measurements in the Higgs, top and beyond Standard model sector, presenting the capabilities of CLIC for high precision measurements.

  15. CLIC Detector Power Requirements

    CERN Document Server

    Gaddi, A

    2013-01-01

    An estimate for the CLIC detector power requirements is outlined starting from the available data on power consumptions of the four LHC experiments and considering the differences between a typical LHC Detector (CMS) and the CLIC baseline detector concept. In particular the impact of the power pulsing scheme for the CLIC Detector electronics on the overall detector consumption is considered. The document will be updated with the requirements of the sub-detector electronics once they are more defined.

  16. CLIC: Status and Plan

    CERN Document Server

    Sailer, Andre

    2014-01-01

    The Compact Linear Collider (CLIC) is a high energy electron–positron col- lider with a maximal centre-of-mass energy of 3 TeV. In order to achieve high luminosity small bunches with high intensity are necessary. These lead to strong beam-beam forces, which create a challenging background environment. The accelerator concept and the detectors designed for CLIC are presented. Results from detector benchmark studies presented in the CLIC conceptual design report are summarised.

  17. Collective effects and experimental verification of the CLIC drive beam and decelerator

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00418229; Stapnes, Steinar; Adli, Erik

    The Compact Linear Collider (CLIC) is a potential next-generation particle collider, in which electrons and positrons collide at a center-of-mass energy of up to 3 TeV. In order to reach a high accelerating gradient and reduce the length of the machine, CLIC uses a novel two-beam scheme. Here, the acceleration energy for the main beam is provided by energy extraction from a secondary electron drive beam, by the use of Power Extraction and Transfer Structures (PETS). This Ph.D. thesis describes deceleration measurements from the CLIC Test Facility 3 at CERN, from a beam that had up to 37 % of its kinetic energy converted into 12 GHz rf power. The results are part of the feasibility demonstration of the CLIC scheme. The measured difference in beam energy of the decelerated beam is correlated with particle tracking simulations and with predictions based on analytical formulae, and a very good agreement is demonstrated. The evolution of the transverse emittance was also studied, since it is critical to contain th...

  18. Work on PETS Developed at CIEMAT

    CERN Document Server

    Sanchez, Laura; Calero, Jesus; Carrillo, David; Gavela, Daniel; Gutierrez, Jose Luis; Lara, Alvaro; Rodriguez, Enrique; Toral, Fernando; Doebert, Steffen; Riddone, Germana; Samoshkin, Alexandre

    2012-01-01

    CIEMAT has been working on the RF power extractor so-called PETS (Power Extraction and Transfer Structure) for the CLIC Test Facility 3 (CTF3) since 2007. The first contribution has been installed at the Test Beam Line (TBL). Additionally, a new PETS configuration is presently under fabrication at CIEMAT and will be installed in the Test Module at CTF3. This paper describes the PETS prototypes design, fabrication and assembly techniques. The characterization of the devices with low RF power is also described.

  19. From glutathione transferase to pore in a CLIC

    CERN Document Server

    Cromer, B A; Morton, C J; Parker, M W; 10.1007/s00249-002-0219-1

    2002-01-01

    Many plasma membrane chloride channels have been cloned and characterized in great detail. In contrast, very little is known about intracellular chloride channels. Members of a novel class of such channels, called the CLICs (chloride intracellular channels), have been identified over the last few years. A striking feature of the CLIC family of ion channels is that they can exist in a water- soluble state as well as a membrane-bound state. A major step forward in understanding the functioning of these channels has been the recent crystal structure determination of one family member, CLIC1. The structure confirms that CLICs are members of the glutathione S- transferase superfamily and provides clues as to how CLICs can insert into membranes to form chloride channels. (69 refs).

  20. CLIC brochure (English version)

    CERN Multimedia

    Lefevre, Christiane

    2012-01-01

    The world's biggest and most powerful accelerator, the LHC, is mapping the route of particle physics for the future. The next step, to complement the LHC in exploring this new region, is most likely to be a linear electron-positron collider. The Compact Linear Collider (CLIC) is a novel approach to such a collider. It is currently under development by the CLIC collaboration, which is hosted at CERN.

  1. CLIC two-beam module design and integration

    CERN Document Server

    Riddone, G; Gudkov, D

    2010-01-01

    Abstract The Compact LInear Collider (CLIC) is based on twobeam acceleration concept currently developed at CERN. The RF power is generated by a high-current electronbeam, called Drive Beam, (DB) running parallel to the Main Beam (MB). The DB is decelerated in dedicated power extraction structures (PETS) and the generated RF power is transferred via waveguides to the accelerating structures (AS). To facilitate the matching of the beams, components are assembled in 2-m long modules of few different types. Special modules are needed in damping regions or to contain dedicated instrumentation and vacuum equipment. The module design and integration has to cope with challenging requirements from the different technical systems. This paper reports the status of the engineering design and related technical issues.

  2. Physics at CLIC

    CERN Document Server

    CERN. Geneva

    2017-01-01

    The Compact Linear Collider (CLIC) is a high-energy e+e- collider under development. The CLIC conceptual design report, published in 2012, concentrated on 3 TeV centre-of-mass energy. At that time operation at lower energies was not yet studied at the same level. Following the discovery of the Higgs boson, the CLIC potential for precision Higgs measurements was addressed for several centre-of-mass energies. In parallel, the scope for precision top quark physics was further explored. As a result an optimised CLIC staging scenario was defined in collaboration between accelerator and detector experts. The staging scenario aims at a maximum physics output and maximum luminosity yield with a collider built and operated in three energy steps: 380 GeV, 1.5 TeV, 3 TeV. The seminar will comprise a short status report on the CLIC accelerator and detector. Emphasis will be on the CLIC physics potential for Higgs, top quark and BSM physics in the new staging scenario.

  3. Surface structure of oriented PET films

    CERN Document Server

    Kirov, K

    2001-01-01

    crystallinity and the level of molecular orientation of the polymer are highest at the film surface and gradually decrease away from it. The same trend for an increase in structural order nearer the film surface was observed in a series of PET films drawn uniaxially in laboratory conditions. The observed strong dependence of stratification in the oriented films on drawing ratio, lead to the conclusion, that the structural gradients arise as a result of viscous flow. The molecular mechanism of stratification is discussed and leads to the idea of enhanced chain mobility at the PET film surface. The idea is in line with recent studies showing a depression of the glass transition temperature of free polymer surfaces. In addition, the results on structure formation in PET films during drawing, give support to the existing view that polymer crystallisation is assisted by a spinodal-decomposition nucleation process. Polymer films are widely used as substrates in nano-composite materials and therefore have to possess...

  4. The CLIC Detector Concept

    CERN Document Server

    Pitters, Florian Michael

    2016-01-01

    CLIC is a concept for a future linear collider that would provide e+e- collisions at up to 3 TeV. The physics aims require a detector system with excellent jet energy and track momentum resolution, highly efficient flavour-tagging and lepton identification capabilities, full geometrical coverage extending to low polar angles and timing information in the order of nanoseconds to reject beam-induced background. To deal with those requirements, an extensive R&D programme is in place to overcome current technological limits. The CLIC detector concept includes a low-mass all-silicon vertex and tracking detector system and fine-grained calorimeters designed for particle flow analysis techniques, surrounded by a 4 T solenoid magnet. An overview of the requirements and design optimisations for the CLIC detector concept is presented.

  5. CLIC Muon Sweeper Design

    CERN Document Server

    Aloev, A; Gatignon, L; Modena, M; Pilicer, B; Tapan, I

    2016-01-01

    There are several background sources which may affect the analysis of data and detector performans at the CLIC project. One of the important background source is halo muons, which are generated along the beam delivery system (BDS), for the detector performance. In order to reduce muon background, magnetized muon sweepers have been used as a shielding material that is already described in a previous study for CLIC [1]. The realistic muon sweeper has been designed with OPERA. The design parameters of muon sweeper have also been used to estimate muon background reduction with BDSIM Monte Carlo simulation code [2, 3].

  6. Detector Systems at CLIC

    CERN Document Server

    Simon, Frank

    2011-01-01

    The Compact Linear Collider CLIC is designed to deliver e+e- collisions at a center of mass energy of up to 3 TeV. The detector systems at this collider have to provide highly efficient tracking and excellent jet energy resolution and hermeticity for multi-TeV final states with multiple jets and leptons. In addition, the detector systems have to be capable of distinguishing physics events from large beam-induced background at a crossing frequency of 2 GHz. Like for the detector concepts at the ILC, CLIC detectors are based on event reconstruction using particle flow algorithms. The two detector concepts for the ILC, ILD and SID, were adapted for CLIC using calorimeters with dense absorbers limiting leakage through increased compactness, as well as modified forward and vertex detector geometries and precise time stamping to cope with increased background levels. The overall detector concepts for CLIC are presented, with particular emphasis on the main detector and engineering challenges, such as: the ultra-thi...

  7. Brazing of Mo to a CuZr alloy for the production of bimetallic raw materials for the CLIC accelerating structures

    CERN Document Server

    Salvo, M; Heikkinen, Samuli; Salvo, Milena; Casalegno, Valentina; Sgobba, Stefano; Rizzo, Stefano; Izquierdo, Gonzalo Arnau; Taborelli, Mauro

    2010-01-01

    Future linear accelerators, as CLIC (Compact Linear Collider), are extremely demanding in terms of material properties. Traditionally accelerating structure is made of brazed OFE copper parts. For the high conducting regions submitted to mechanical fatigue, CuZr would represent an improved selection than pure copper while for regions where the highest electric field is applied a refractory metal, i.e. Mo, could result in a better performance. The feasibility of joining such materials, namely CuZr (UNS C15000) and pure Mo has been investigated. The joining method developed and investigated here consists in a vacuum brazing process exploiting a Cu-based brazing filler applied under appropriate vacuum conditions. Apparent shear strength (adapted from ASTM B898) on the joined samples was about 200 MPa. (C) 2010 Elsevier B.V. All rights reserved.

  8. CLIC Final Focus Studies

    CERN Document Server

    Tomás, R; Schulte, Daniel; Zimmermann, Frank

    2006-01-01

    The CLIC final focus system has been designed based on the local compensation scheme proposed by P. Raimondi and A. Seryi. However, there exist important chromatic aberrations that deteriorate the performance of the system. This paper studies the optimization of the final focus based on the computation of the higher orders of the map using MAD-X and PTC. The use of octupole tail folding to reduce the size of the halo in the locations with aperture limitations is also discussed.

  9. BSM physics at CLIC

    CERN Document Server

    Simoniello, Rosa

    2016-01-01

    The Compact Linear Collider (CLIC) is an option for a future electron-positron collider operating at centre-of-mass energies from a few hundred GeV up to 3 TeV. The search for phenomena beyond the Standard Model through direct observation of new particles and precision measurements is one of the main motivations for the high-energy stages of CLIC. An overview of physics benchmark studies assuming different new physics scenarios is given in this contribution. These studies are based on full detector simulations. New particles can be discovered in most of the considered scenarios almost up to the kinematic limit ($\\sqrt{s}$/2 for pair production). The low background conditions at CLIC provide extended discovery potential compared to hadron colliders, for example in the case of non-coloured TeV-scale SUSY particles. In addition to direct particle searches, BSM models can be probed up to scales of tens of TeV through precision measurements. Examples, including recent results on the reaction $e^+e^- \\to \\gamma\\gam...

  10. Higgs physics at CLIC

    CERN Document Server

    Lukić, Strahinja

    2016-01-01

    The Compact Linear Collider CLIC is an option for a future multi-TeV electron-positron collider, offering the potential for a rich precision physics programme, combined with sensitivity to a wide range of new phenomena. The CLIC physics potential for measurements of the 125 GeV Higgs boson has been studied using full detector simulations for several centre-of-mass energies. The presented results provide crucial input to the energy staging strategy for the CLIC accelerator. The complete physics program for measurements of accessible Higgs boson couplings is presented in this contribution. The ultimate measurement precision is reached when all measurements available at a given centre-of-mass energy are included in combined fits. Operation at a few hundred GeV allows the couplings and width of the Higgs boson to be determined in a model-independent manner through the study of the Higgsstrahlung and WW-fusion processes. At a lepton collider, the measurement of the Higgsstrahlung cross section using the recoil mas...

  11. Higgs physics at CLIC

    CERN Document Server

    AUTHOR|(SzGeCERN)613844

    2016-01-01

    The Compact Linear Collider CLIC is an option for a future multi-TeV electron-positron collider, offering the potential for a rich precision physics programme, combined with sensitivity to a wide range of new phenomena. The CLIC physics potential for measurements of the 125 GeV Higgs boson has been studied using full detector simulations for several centre-of-mass energies. The presented results provide crucial input to the energy staging strategy for the CLIC accelerator. The complete physics program for measurements of accessible Higgs boson couplings is presented in this talk. All measurements available at a given centre-of-mass energy were included in combined fits. Operation at a few hundred GeV allows the couplings and width of the Higgs boson to be determined in a model-independent manner through the study of the Higgsstrahlung and WW-fusion processes. At a lepton collider, the measurement of the Higgsstrahlung cross section using the recoil mass technique sets the absolute scale for all Higgs coupling...

  12. Status of Wakefield Monitor Experiments at the CLIC Test Facility

    CERN Document Server

    Lillestøl, Reidar; Aftab, Namra; Corsini, Roberto; Döbert, Steffen; Farabolini, Wilfrid; Grudiev, Alexej; Javeed, Sumera; Pfingstner, Juergen; Wuensch, Walter

    2016-01-01

    For the very low emittance beams in CLIC, it is vital to mitigate emittance growth which leads to reduced luminosity in the detectors. One factor that leads to emittance growth is transverse wakefields in the accelerating structures. In order to combat this the structures must be aligned with a precision of a few um. For achieving this tolerance, accelerating structures are equipped with wakefield monitors that measure higher-order dipole modes excited by the beam when offset from the structure axis. We report on such measurements, performed using prototype CLIC accelerating structures which are part of the module installed in the CLIC Test Facility 3 (CTF3) at CERN. Measurements with and without the drive beam that feeds rf power to the structures are compared. Improvements to the experimental setup are discussed, and finally remaining measurements that should be performed before the completion of the program are summarized.

  13. CLIC Detector and Physics Status

    CERN Document Server

    Van Der Kolk, Naomi

    2017-01-01

    This contribution to LCWS2016 presents recent developments within the CLICdp collaboration. An updated scenario for the staged operation of CLIC has been published; the accelerator will operate at 380 GeV, 1.5 TeV and 3 TeV. The lowest energy stage is optimised for precision Higgs and top physics, while the higher energy stages offer extended Higgs and BSM physics sensitivity. The detector models CLIC_SiD and CLIC_ILD have been replaced by a single optimised detector; CLICdet. Performance studies and R&D in technologies to meet the requirements for this detector design are ongoing.

  14. Progress on the CLIC Linear Collider Study

    CERN Document Server

    Guignard, Gilbert

    2001-01-01

    The CLIC study aims at a multi-TeV, high luminosity e+e- linear collider design. Beam acceleration uses high frequency (30 GHz), normal conducting structures operating at high accelerating gradients, in order to reduce the length and, in consequence, the cost of the linac. The cost-effective RF power production scheme, based on the so-called Two-beam Acceleration method, enables electrons and positrons to be collided at energies ranging from ~ 0.1 TeV up to a maximum of 5 TeV, in stages. A road map has been drawn up to indicate the research and development necessary to demonstrate the technical feasibility of a 3 TeV centre-of-mass collider with a luminosity of 1035 cm-2s-1. Considerable progress has been made in meeting the challenges associated with the CLIC technology and the present paper briefly reviews some of them. In particular, the status is given of the studies on the CLIC high-gradient structures, the dynamic time-dependent effects, the stabilisation of the vibration and the beam delivery system. T...

  15. CLIC CDR - physics and detectors: CLIC conceptual design report.

    Energy Technology Data Exchange (ETDEWEB)

    Berger, E.; Demarteau, M.; Repond, J.; Xia, L.; Weerts, H. (High Energy Physics); (Many)

    2012-02-10

    This report forms part of the Conceptual Design Report (CDR) of the Compact LInear Collider (CLIC). The CLIC accelerator complex is described in a separate CDR volume. A third document, to appear later, will assess strategic scenarios for building and operating CLIC in successive center-of-mass energy stages. It is anticipated that CLIC will commence with operation at a few hundred GeV, giving access to precision standard-model physics like Higgs and top-quark physics. Then, depending on the physics landscape, CLIC operation would be staged in a few steps ultimately reaching the maximum 3 TeV center-of-mass energy. Such a scenario would maximize the physics potential of CLIC providing new physics discovery potential over a wide range of energies and the ability to make precision measurements of possible new states previously discovered at the Large Hadron Collider (LHC). The main purpose of this document is to address the physics potential of a future multi-TeV e{sup +}e{sup -} collider based on CLIC technology and to describe the essential features of a detector that are required to deliver the full physics potential of this machine. The experimental conditions at CLIC are significantly more challenging than those at previous electron-positron colliders due to the much higher levels of beam-induced backgrounds and the 0.5 ns bunch-spacing. Consequently, a large part of this report is devoted to understanding the impact of the machine environment on the detector with the aim of demonstrating, with the example of realistic detector concepts, that high precision physics measurements can be made at CLIC. Since the impact of background increases with energy, this document concentrates on the detector requirements and physics measurements at the highest CLIC center-of-mass energy of 3 TeV. One essential output of this report is the clear demonstration that a wide range of high precision physics measurements can be made at CLIC with detectors which are challenging, but

  16. Academic Training - Technological challenges of CLIC

    CERN Multimedia

    Françoise Benz

    2006-01-01

    2005-2006 ACADEMIC TRAINING PROGRAMME LECTURE SERIES 12, 13, 14, 15 and 16 June 11:00-12:00 - Auditorium, bldg 500 Technological challenges of CLIC R. Corsini, S. Doebert, S. Redaelli, T.Lefevre, CERN-AB and G. Arnau Izquierdo, H. Mainaud, CERN-TS Future e+e- Linear Colliders offer the potential to explore new physics at the TeV scale and beyond to very high precision. While the International Linear Collider (ILC) scheme of a collider in the 0.5 - 1 TeV range enters the engineering design phase, the Compact Linear Collider (CLIC) study explores the technical feasibility of a collider capable of reaching into the multi-TeV energy domain. Key ingredients of the CLIC scheme are acceleration at high-frequency (30 GHz) and high-gradient (150 MV/m) in normal conducting structures and the use of the so-called Two Beam Acceleration concept, where a high-charge electron beam (drive beam) running parallel to the main beam is decelerated to provide the RF power to accelerate the main beam itself. A vigorous R&...

  17. CLIC Quadrupole Module final report

    CERN Document Server

    Artoos, K; Mainaud-Durand, H

    2013-01-01

    Future Linear colliders will need particle beam sizes in the nanometre range. The beam also needs to be stable all along the beam line. The CLIC Main Beam Quadrupole (MBQ) module has been defined and studied. It is meant as a test stand for stabilisation and pre-alignment with a MB Quadrupole. The main topic that has been tackled concerns the Quadrupole magnet stabilisation to 1nm at 1Hz. This is needed to obtain the desired CLIC luminosity of 2.1034 cm-2m-1. The deliverable was demonstrated by procuring a MBQ and by stabilising a powered and cooled CLIC MBQ quadrupole. In addition, the stabilisation system has to be compatible with the pre-alignment procedures. Pre-alignment movement resolution has been demonstrated to 1m. The last step is the combined test of stability with a quadrupole on a CLIC Module with the pre-alignment.

  18. The Physics Prospects for CLIC

    CERN Document Server

    ELLIS, J.

    2008-01-01

    Following a brief outline of the CLIC project, this talk summarizes some of the principal motivations for an e+e− collider with ECM = 3 TeV. It is shown by several examples that CLIC would represent a significant step beyond the LHC and ILC in its capabilities for precision measurements at high energies. It would make possible a complete study of a light Higgs boson, including rare decay modes, and would provide a unique tool to study a heavy Higgs boson. CLIC could also complete the studies of supersymmetric spectra, if sparticles are relatively light, and discover any heavier sparticles. It would also enable deeper probes of extra dimensions, new gauge bosons and excited quarks or leptons. CLIC has unique value to add to experimental particle physics, whatever the LHC discovers.

  19. The CLIC Physics Potential

    CERN Document Server

    AUTHOR|(SzGeCERN)554857

    2016-01-01

    The physics and detector studies for the Compact Linear Collider (CLIC) are introduced. A staged programme of $e^{+}e^{−}$ collisions covering $\\sqrt{s}$ = 380 GeV, 1.5 TeV, and 3 TeV would allow precise measurements of Higgs boson couplings, in many cases to the percent level. This corresponds to precision higher than that expected for the high-luminosity Large Hadron Collider. Such precise Higgs coupling measurements would allow sensitivity to a variety of new physics models and the ability to distinguish between them. In addition, new particles directly produced in pairs could be measured with great precision, and measurements in the top-quark sector would provide sensitivity to new physics effects at the scales of tens of TeV.

  20. Thermal Fatigue of Polycrystalline Copper in CLIC Accelerating Structures: Surface Roughening and Hardening as a Function of Grain Orientation

    CERN Document Server

    Aicheler, M

    2010-01-01

    The ac­cel­er­at­ing struc­tures of CLIC will be sub­mit­ted to 2 x 1010 ther­mal-me­chan­i­cal fa­tigue cy­cles, aris­ing from Radio Fre­quen­cy (RF) in­duced eddy cur­rents, caus­ing local su­per­fi­cial cyclic heat­ing. In order to as­sess the ef­fects of su­per­fi­cial fa­tigue, high tem­per­a­ture an­nealed OFE Cop­per sam­ples were ther­mal­ly fa­tigued with the help of pulsed laser ir­ra­di­a­tion. They un­der­went post­mortem Elec­tron Backscat­tered Diffrac­tion (EBSD) mea­sure­ments andμhard­ness ob­ser­va­tions. Pre­vi­ous work has con­firmed that sur­face rough­en­ing de­pends on the ori­en­ta­tion of near-sur­face grains*,**. It is clear­ly ob­served that, through ther­mal cy­cling, the in­crease of hard­ness of a crys­tal­lo­graph­ic di­rec­tion is re­lat­ed to the amount of sur­face rough­en­ing in­duced by fa­tigue. Near-sur­face grains, ori­ent­ed [1 0 0] with re­spect to the sur­face, ex­hibit­ing ver...

  1. Spectrometers for RF breakdown studies for CLIC

    Science.gov (United States)

    Jacewicz, M.; Ziemann, V.; Ekelöf, T.; Dubrovskiy, A.; Ruber, R.

    2016-08-01

    An e+e- collider of several TeV energy will be needed for the precision studies of any new physics discovered at the LHC collider at CERN. One promising candidate is CLIC, a linear collider which is based on a two-beam acceleration scheme that efficiently solves the problem of power distribution to the acceleration structures. The phenomenon that currently prevents achieving high accelerating gradients in high energy accelerators such as the CLIC is the electrical breakdown at very high electrical field. The ongoing experimental work within the CLIC collaboration is trying to benchmark the theoretical models focusing on the physics of vacuum breakdown which is responsible for the discharges. In order to validate the feasibility of accelerating structures and observe the characteristics of the vacuum discharges and their eroding effects on the structure two dedicated spectrometers are now commissioned at the high-power test-stands at CERN. First, the so called Flashbox has opened up a possibility for non-invasive studies of the emitted breakdown currents during two-beam acceleration experiments. It gives a unique possibility to measure the energy of electrons and ions in combination with the arrival time spectra and to put that in context with accelerated beam, which is not possible at any of the other existing test-stands. The second instrument, a spectrometer for detection of the dark and breakdown currents, is operated at one of the 12 GHz stand-alone test-stands at CERN. Built for high repetition rate operation it can measure the spatial and energy distributions of the electrons emitted from the acceleration structure during a single RF pulse. Two new analysis tools: discharge impedance tracking and tomographic image reconstruction, applied to the data from the spectrometer make possible for the first time to obtain the location of the breakdown inside the structure both in the transversal and longitudinal direction thus giving a more complete picture of the

  2. PET

    DEFF Research Database (Denmark)

    Mariager, Rasmus Mølgaard; Schmidt, Regin; Heiberg, Morten Rievers

    PET handler om den hemmelige tjenestes arbejde under den kolde krig 1945-1989. Her fortæller Regin Schmidt, Rasmus Mariager og Morten Heiberg om de mest dramatiske og interessante sager fra PET's arkiv. PET er på flere måder en udemokratisk institution, der er sat til at vogte over demokratiet....... Dens virksomhed er skjult for offentligheden, den overvåger borgernes aktiviteter, og den registrerer følsomme personoplysninger. Historien om PET rejser spørgsmålet om, hvad man skal gøre, når befolkningen i et demokrati er kritisk indstillet over for overvågningen af lovlige politiske aktiviteter......, mens myndighederne mener, at det er nødvendigt for at beskytte demokratiet. PET er på en gang en fortælling om konkrete aktioner og begivenheder i PET's arbejde og et stykke Danmarkshistorie. Det handler om overvågning, spioner, politisk ekstremisme og international terrorisme.  ...

  3. Cholesterol Promotes Interaction of the Protein CLIC1 with Phospholipid Monolayers at the Air–Water Interface

    Directory of Open Access Journals (Sweden)

    Khondker R. Hossain

    2016-02-01

    Full Text Available CLIC1 is a Chloride Intracellular Ion Channel protein that exists either in a soluble state in the cytoplasm or as a membrane bound protein. Members of the CLIC family are largely soluble proteins that possess the intriguing property of spontaneous insertion into phospholipid bilayers to form integral membrane ion channels. The regulatory role of cholesterol in the ion-channel activity of CLIC1 in tethered lipid bilayers was previously assessed using impedance spectroscopy. Here we extend this investigation by evaluating the influence of cholesterol on the spontaneous membrane insertion of CLIC1 into Langmuir film monolayers prepared using 1-palmitoyl-2-oleoylphosphatidylcholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-ethanolamine and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine alone or in combination with cholesterol. The spontaneous membrane insertion of CLIC1 was shown to be dependent on the presence of cholesterol in the membrane. Furthermore, pre-incubation of CLIC1 with cholesterol prior to its addition to the Langmuir film, showed no membrane insertion even in monolayers containing cholesterol, suggesting the formation of a CLIC1-cholesterol pre-complex. Our results therefore suggest that CLIC1 membrane interaction involves CLIC1 binding to cholesterol located in the membrane for its initial docking followed by insertion. Subsequent structural rearrangements of the protein would likely also be required along with oligomerisation to form functional ion channels.

  4. Cholesterol Promotes Interaction of the Protein CLIC1 with Phospholipid Monolayers at the Air–Water Interface

    Science.gov (United States)

    Hossain, Khondker R.; Al Khamici, Heba; Holt, Stephen A.; Valenzuela, Stella M.

    2016-01-01

    CLIC1 is a Chloride Intracellular Ion Channel protein that exists either in a soluble state in the cytoplasm or as a membrane bound protein. Members of the CLIC family are largely soluble proteins that possess the intriguing property of spontaneous insertion into phospholipid bilayers to form integral membrane ion channels. The regulatory role of cholesterol in the ion-channel activity of CLIC1 in tethered lipid bilayers was previously assessed using impedance spectroscopy. Here we extend this investigation by evaluating the influence of cholesterol on the spontaneous membrane insertion of CLIC1 into Langmuir film monolayers prepared using 1-palmitoyl-2-oleoylphosphatidylcholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-ethanolamine and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine alone or in combination with cholesterol. The spontaneous membrane insertion of CLIC1 was shown to be dependent on the presence of cholesterol in the membrane. Furthermore, pre-incubation of CLIC1 with cholesterol prior to its addition to the Langmuir film, showed no membrane insertion even in monolayers containing cholesterol, suggesting the formation of a CLIC1-cholesterol pre-complex. Our results therefore suggest that CLIC1 membrane interaction involves CLIC1 binding to cholesterol located in the membrane for its initial docking followed by insertion. Subsequent structural rearrangements of the protein would likely also be required along with oligomerisation to form functional ion channels. PMID:26875987

  5. A 12 GHz RF Power Source for the CLIC Study

    Energy Technology Data Exchange (ETDEWEB)

    Schirm, Karl; /CERN; Curt, Stephane; /CERN; Dobert, Steffen; /CERN; McMonagle, Gerard; /CERN; Rossat, Ghislain; /CERN; Syratchev, Igor; /CERN; Timeo, Luca; /CERN; Haase, Andrew /SLAC; Jensen, Aaron; /SLAC; Jongewaard, Erik; /SLAC; Nantista, Christopher; /SLAC; Sprehn, Daryl; /SLAC; Vlieks, Arnold; /SLAC; Hamdi, Abdallah; /Saclay; Peauger, Franck; /Saclay; Kuzikov, Sergey; /Nizhnii Novgorod, IAP; Vikharev, Alexandr; /Nizhnii Novgorod, IAP

    2012-07-03

    The CLIC RF frequency has been changed in 2008 from the initial 30 GHz to the European X-band 11.9942 GHz permitting beam independent power production using klystrons for CLIC accelerating structure testing. A design and fabrication contract for five klystrons at that frequency has been signed by different parties with SLAC. France (IRFU, CEA Saclay) is contributing a solid state modulator purchased in industry and specific 12 GHz RF network components to the CLIC study. RF pulses over 120 MW peak at 230 ns length will be obtained by using a novel SLED-I type pulse compression scheme designed and fabricated by IAP, Nizhny Novgorod, Russia. The X-band power test stand is being installed in the CLIC Test Facility CTF3 for independent structure and component testing in a bunker, but allowing, in a later stage, for powering RF components in the CTF3 beam lines. The design of the facility, results from commissioning of the RF power source and the expected performance of the Test Facility are reported.

  6. A 12 GHZ RF Power source for the CLIC study

    CERN Document Server

    Peauger, F; Curt, S; Doebert, S; McMonagle, G; Rossat, G; Schirm, KM; Syratchev, I; Timeo, L; Kuzikhov, S; Vikharev, AA; Haase, A; Sprehn, D; Jensen, A; Jongewaard, EN; Nantista, CD; Vlieks, A

    2010-01-01

    The CLIC RF frequency has been changed in 2008 from the initial 30 GHz to the European X-band 11.9942 GHz permitting beam independent power production using klystrons for CLIC accelerating structure testing. A design and fabrication contract for five klystrons at that frequency has been signed by different parties with SLAC. France (IRFU, CEA Saclay) is contributing a solid state modulator purchased in industry and specific 12 GHz RF network components to the CLIC study. RF pulses over 120 MW peak at 230 ns length will be obtained by using a novel SLED-I type pulse compression scheme designed and fabricated by IAP, Nizhny Novgorod, Russia. The X-band power test stand is being installed in the CLIC Test Facility CTF3 for independent structure and component testing in a bunker, but allowing, in a later stage, for powering RF components in the CTF3 beam lines. The design of the facility, results from commissioning of the RF power source and the expected performance of the Test Facility are reported.

  7. ATF2 tests and CLIC IR study

    CERN Document Server

    Angal-Kalinin, D; Jones, J; Scarfe, A; Tygier, S

    2013-01-01

    This task covered three separate subtasks dealing with ILC and CLIC beam delivery system and Interaction region studies as well as testing the tuning procedures at ATF2 final focus test facility. The proposed local chromaticity correction final focus system for both ILC as well as CLIC is being tested experimentally for the first time at ATF2, various tuning procedures have been applied to study the applicability of various procedures to the ILC and CLIC to optimize the interaction region. The CLIC IR region was studied in detail, and the impact and mitigation of CLIC detector solenoid effects on the beam orbit, coupling and extraction have been considered. The work programme of this task concentrated on central region integration of the ILC following the design changes proposed during the technical design phase of the ILC, participation in ATF2 beam tuning studies and CLIC interaction region studies.

  8. CLIC expands to include the Southern Hemisphere

    CERN Multimedia

    Roberto Cantoni

    2010-01-01

    Australia has recently joined the CLIC collaboration: the enlargement will bring new expertise and resources to the project, and is especially welcome in the wake of CERN budget redistributions following the recent adoption of the Medium Term Plan.   The countries involved in CLIC collaboration With the signing of a Memorandum of Understanding on 26 August 2010, the ACAS network (Australian Collaboration for Accelerator Science) became the 40th member of in the multilateral CLIC collaboration making Australia the 22nd country to join the collaboration. “The new MoU was signed by the ACAS network, which includes the Australian Synchrotron and the University of Melbourne”, explains Jean-Pierre Delahaye, CLIC Study Leader. “Thanks to their expertise, the Australian institutes will contribute greatly to the CLIC damping rings and the two-beam test modules." Institutes from any country wishing to join the CLIC collaboration are invited to assume responsibility o...

  9. CLIC vertex detector R&D

    CERN Document Server

    AUTHOR|(SzGeCERN)734627

    2015-01-01

    A vertex-detector concept is under development for the proposed multi-TeV linear e+e- Compact Linear Collider (CLIC). To perform precision physics measurements in a chal- lenging environment, the CLIC vertex detector pushes the technological requirements to the limits. This paper reviews the requirements for the CLIC vertex detector and gives an over- view of recent R&D achievements in the domains of sensor, readout, powering and cooling.

  10. CLIC vertex detector R&D

    Science.gov (United States)

    Alipour Tehrani, Niloufar

    2016-07-01

    A vertex detector concept is under development for the proposed multi-TeV linear e+e- Compact Linear Collider (CLIC). To perform precision physics measurements in a challenging environment, the CLIC vertex detector pushes the technological requirements to the limits. This paper reviews the requirements for the CLIC vertex detector and gives an overview of recent R&D achievements in the domains of sensor, readout, powering and cooling.

  11. Studies on the thermo-mechanical behavior of the CLIC two-beam module

    CERN Document Server

    Nousiainen, R; Österberg, K

    2010-01-01

    To fulfil the mechanical requirements set by the luminosity goals of the CLIC collider, currently under study, the 2-m two-beam modules, the shortest repetitive elements in the main linac, have to be controlled at micrometer level. At the same time these modules are exposed to variable high power dissipation while the accelerator is ramped up to nominal power as well as when the mode of CLIC operation is varied. This will result into inevitable temperature excursions driving mechanical distortions in and between different module components. A FEM model is essential to estimate and simulate the fundamental thermo-mechanical behaviour of the CLIC two-beam module to facilitate its design and development. In this paper, the fundamental thermal environments for the RF-components of the module are described. Also the thermal and structural results for the studied module configuration are presented showing the fundamental thermo-mechanical behaviour under the main CLIC collider operation conditions.

  12. Experimental Program for the CLIC test facility 3 test beam line

    CERN Document Server

    Adli, E; Dobert, S; Olvegaard, M; Schulte, D; Syratchev, I; Lillestol, Reidar

    2010-01-01

    The CLIC Test Facility 3 Test Beam Line is the first prototype for the CLIC drive beam decelerator. Stable transport of the drive beam under deceleration is a mandatory component in the CLIC two-beam scheme. In the Test Beam Line more than 50% of the total energy will be extracted from a 150 MeV, 28 A electron drive beam, by the use of 16 power extraction and transfer structures. A number of experiments are foreseen to investigate the drive beam characteristics under deceleration in the Test Beam Line, including beam stability, beam blow up and the efficiency of the power extraction. General benchmarking of decelerator simulation and theory studies will also be performed. Specially designed instrumentation including precision BPMs, loss monitors and a time-resolved spectrometer dump will be used for the experiments. This paper describes the experimental program foreseen for the Test Beam Line, including the relevance of the results for the CLIC decelerator studies.

  13. Tissue and subcellular distribution of CLIC1

    Directory of Open Access Journals (Sweden)

    Edwards John C

    2007-02-01

    Full Text Available Abstract Background CLIC1 is a chloride channel whose cellular role remains uncertain. The distribution of CLIC1 in normal tissues is largely unknown and conflicting data have been reported regarding the cellular membrane fraction in which CLIC1 resides. Results New antisera to CLIC1 were generated and were found to be sensitive and specific for detecting this protein. These antisera were used to investigate the distribution of CLIC1 in mouse tissue sections and three cultured cell lines. We find CLIC1 is expressed in the apical domains of several simple columnar epithelia including glandular stomach, small intestine, colon, bile ducts, pancreatic ducts, airway, and the tail of the epididymis, in addition to the previously reported renal proximal tubule. CLIC1 is expressed in a non-polarized distribution in the basal epithelial cell layer of the stratified squamous epithelium of the upper gastrointesitinal tract and the basal cells of the epididymis, and is present diffusely in skeletal muscle. Distribution of CLIC1 was examined in Panc1 cells, a relatively undifferentiated, non-polarized human cell line derived from pancreatic cancer, and T84 cells, a human colon cancer cell line which can form a polarized epithelium that is capable of regulated chloride transport. Digitonin extraction was used to distinguish membrane-inserted CLIC1 from the soluble cytoplasmic form of the protein. We find that digitonin-resistant CLIC1 is primarily present in the plasma membrane of Panc1 cells. In T84 cells, we find digitonin-resistant CLIC1 is present in an intracellular compartment which is concentrated immediately below the apical plasma membrane and the extent of apical polarization is enhanced with forskolin, which activates transepithelial chloride transport and apical membrane traffic in these cells. The sub-apical CLIC1 compartment was further characterized in a well-differentiated mouse renal proximal tubule cell line. The distribution of CLIC1 was

  14. Vector boson scattering at CLIC

    Energy Technology Data Exchange (ETDEWEB)

    Kilian, Wolfgang; Fleper, Christian [Department Physik, Universitaet Siegen, 57068 Siegen (Germany); Reuter, Juergen [DESY Theory Group, 22603 Hamburg (Germany); Sekulla, Marco [Institut fuer Theoretische Physik, Karlsruher Institut fuer Technologie, 76131 Karlsruhe (Germany)

    2016-07-01

    Linear colliders operating in a range of multiple TeV are able to investigate the details of vector boson scattering and electroweak symmetry breaking. We calculate cross sections with the Monte Carlo generator WHIZARD for vector boson scattering processes at the future linear e{sup +} e{sup -} collider CLIC. By finding suitable cuts, the vector boson scattering signal processes are isolated from the background. Finally, we are able to determine exclusion sensitivities on the non-Standard Model parameters of the relevant dimension eight operators.

  15. CLIC inner detectors cooling simulations

    CERN Document Server

    Duarte Ramos, F.; Villarejo Bermudez, M.

    2014-01-01

    The strict requirements in terms of material budget for the inner region of the CLIC detector concepts require the use of a dry gas for the cooling of the respective sen- sors. This, in conjunction with the compactness of the inner volumes, poses several challenges for the design of a cooling system that is able to fulfil the required detec- tor specifications. This note introduces a detector cooling strategy using dry air as a coolant and shows the results of computational fluid dynamics simulations used to validate the proposed strategy.

  16. BDS tuning and luminosity monitoring in CLIC

    CERN Document Server

    Dalena, Barbara; Latina, Andrea; Marin, Eduardo; Pfingstner, Jurgen; Schulte, Daniel; Snuverink, Jochem; Tomas, Rogelio; Zamudio, Guillermo

    2011-01-01

    The emittance preservation in the Beam Delivery System (BDS) is one of the major challenges in CLIC. The fast detuning of the final focus optics requires an on-­line tuning procedure in order to keep luminosity close to the maximum. Different tuning techniques have been applied to the CLIC BDS and in particular to the Final Focus System (FFS) in order to mitigate static and dynamic imperfections. Some of them require a fast luminosity measurement. Here we study the possibility to use beam-­beam backgrounds processes at CLIC 3 TeV CM energy as fast luminosity signal. In particular the hadrons multiplicity in the detector region is investigated.

  17. Precision Higgs boson measurement at CLIC

    CERN Document Server

    AUTHOR|(SzGeCERN)718111

    2016-01-01

    The design of the next generation collider in high energy physics will primarily focus on the possibility to achieve high precision of the measurements of interest. The necessary precision limits are set, in the first place, by the measurement of the Higgs boson but also by measurements that are sensitive to signs of New Physics. The Compact Linear Collider (CLIC) is an attractive option for a future multi-TeV linear electron-positron collider, with the potential to cover a rich physics program with high precision. In this lecture the CLIC accelerator, detector and backgrounds will be presented with emphesis on the capabilities of CLIC for precision Higgs physics.

  18. CLIC's three-step plan

    CERN Multimedia

    Katarina Anthony

    2012-01-01

    In early October, the Compact Linear Collider (CLIC) collaboration published its final Conceptual Design Report. Accompanying it was a strategic summary document that describes a whole new approach to the project: developing the linear e+e− collider in three energy stages. Though CLIC’s future still depends on signs from the LHC, its new staged approach to high-energy electron-positron physics for the post-LHC era is nothing short of convincing.   Instead of asking for a 48-kilometre-long commitment right off the bat, the CLIC collaboration is now presenting an accelerator that can be constructed in stages. For example, it could begin as an 11-kilometre 500 GeV accelerator that could later be extended to a 27-kilometre 1.5 TeV machine. Finally, after a decade or so of data taking, it could be taken up to the full 48-kilometre 3 TeV facility (see image 2). “Not only is the approach technically and financially practical, it also offers a very convincing physics prog...

  19. Golden Jubilee Photos: A CLIC for the future

    CERN Multimedia

    2004-01-01

    http://www.cern.ch/cern50/ Prototype copper accelerating structures for CLIC. New accelerator projects take many years to make and mature. When the LHC project was still only a twinkle in CERN's eye, research was already starting on a new machine. A small team at CERN was setting about the task of studying a high-energy, compact, lepton linear collider, known as CLIC. This is possibly set to become the collider of the future. A machine of this kind has all the advantages of a collider (the total collision energy is equal to the sum of the energies of the two colliding beams) without the drawback of synchrotron radiation, which is produced when particles are accelerated around a ring and thus puts a limit on the energy of such colliders. But in a project as technically challenging as CLIC, considerable technological hurdles must be overcome. To limit the linear collider's length to some tens of kilometres, the beams must acquire a considerable quantity of energy per metre travelled. The collision rate (lumi...

  20. Acquisition system for the CLIC Module

    CERN Document Server

    Vilalte, Sebastien

    2011-01-01

    The status of R&D activities for CLIC module acquisition are discussed [1]. LAPP is involved in the design of the local CLIC module acquisition crate, described in the document Study of the CLIC Module Front-End Acquisition and Evaluation Electronics [2]. This acquisition system is a project based on a local crate, assigned to the CLIC module, including several mother boards. These motherboards are foreseen to hold mezzanines dedicated to the different subsystems. This system has to work in radiation environment. LAPP is involved in the development of Drive Beam stripline position monitors read-out, described in the document Drive Beam Stripline BPM Electronics and Acquisition [3]. LAPP also develops a generic acquisition mezzanine that allows to perform all-around acquisition and components tests for drive beam stripline BPM read-out.

  1. Solenoid and Synchrotron radiation effects in CLIC

    CERN Document Server

    Dalena, B; Tomás, R; Angal-Kalinin, D

    2010-01-01

    The emission of Synchrotron Radiation in the CLIC BDS is one of the major limitations of the machine performance. An extensive revision of this phenomenon is presented with special emphasis on the Interaction point (IP) solenoid.

  2. Successful start for new CLIC test facility

    CERN Multimedia

    2004-01-01

    A new test facility is being built to study key feasibility issues for a possible future linear collider called CLIC. Commissioning of the first part of the facility began in June 2003 and nominal beam parameters have been achieved already.

  3. CLIC CTF3 for open days

    CERN Multimedia

    CLIC

    2013-01-01

    CLIC – the Compact Linear Collider – is a study for a future accelerator that reaches unprecedented energies for electrons and their antimatter twins, positrons. It uses a novel two-beam acceleration scheme in which the electrons and positrons are propelled to high energy by an additional high current electron beam, the so-called Drive Beam. In order to generate this high current Drive Beam, a long train of electron bunches is accelerated, parts of the train delayed in a Delay Loop and Combiner Rings, and interleaved by transversely deflecting radio-frequency cavities. The CLIC Test Facility CTF3, which is shown in the movie, examines the new technologies envisioned by the CLIC design, in particular the Drive Beam generation and the two-beam acceleration. It is a scaled-down version of the CLIC facility, and it has demonstrated the feasibility of the novel scheme.

  4. CLIC CTF3 for open days

    CERN Multimedia

    2013-01-01

    (subt french) CLIC – the Compact Linear Collider – is a study for a future accelerator that reaches unprecedented energies for electrons and their antimatter twins, positrons. It uses a novel two-beam acceleration scheme in which the electrons and positrons are propelled to high energy by an additional high current electron beam, the so-called Drive Beam. In order to generate this high current Drive Beam, a long train of electron bunches is accelerated, parts of the train delayed in a Delay Loop and Combiner Rings, and interleaved by transversely deflecting radio-frequency cavities. The CLIC Test Facility CTF3, which is shown in the movie, examines the new technologies envisioned by the CLIC design, in particular the Drive Beam generation and the two-beam acceleration. It is a scaled-down version of the CLIC facility, and it has demonstrated the feasibility of the novel scheme.

  5. LHC and CLIC LLRF final reports

    CERN Document Server

    Dexter, A; Woolley, B; Ambattu, P; Tahir, I; Syratchev, Igor; Wuensch, Walter

    2013-01-01

    Crab cavities rotate bunches from opposing beams to achieve effective head-on collision in CLIC or collisions at an adjustable angle in LHC. Without crab cavities 90% of achievable luminosity at CLIC would be lost. In the LHC, the crab cavities allow the same or larger integrated luminosity while reducing significantly the requested dynamic range of physics detectors. The focus for CLIC is accurate phase synchronisation of the cavities, adequate damping of wakefields and modest amplitude stability. For the LHC, the main LLRF issues are related to imperfections: beam offsets in cavities, RF noise, measurement noise in feedback loops, failure modes and mitigations. This report develops issues associated with synchronising the CLIC cavities. It defines an RF system and experiments to validate the approach. It reports on the development of hardware for measuring the phase performance of the RF distributions system and cavities. For the LHC, the hardware being very close to the existing LLRF, the report focuses on...

  6. RF Design of the TW Buncher for the CLIC Drive Beam Injector (2nd report)

    CERN Document Server

    Shaker, Hamed

    2016-01-01

    CLIC is based on the two beams concept that one beam (drive beam) produces the required RF power to accelerate another beam (main beam). The drive beam is produced and accelerated up to 50MeV inside the CLIC drive beam injector. The drive beam injector main components are a thermionic electron gun, three sub-harmonic bunchers, a pre-buncher, a TW buncher, 13 accelerating structures and one magnetic chicane. This document is the second report of the RF structure design of the TW buncher. This design is based on the beam dynamic design done by Shahin Sanaye Hajari due to requirements mentioned in CLIC CDR. A disk-loaded tapered structure is chosen for the TW buncher. The axial electric field increases strongly based on the beam dynamic requirements. This second report includes the study of HOM effects, retuning the cells, study of dimensional tolerances and the heat dissipation on the surface.

  7. A Luminosity Calorimeter for CLIC

    CERN Document Server

    Abramowicz, H; Kananov, S; Levy, A; Sadeh, I

    2009-01-01

    For the relative precision of the luminosity measurement at CLIC, a preliminary target value of 1% is being assumed. This may be accomplished by constructing a finely granulated calorimeter, which will measure Bhabha scattering at small angles. In order to achieve the design goal, the geometrical parameters of the calorimeter need to be defined. Several factors influence the design of the calorimeter; chief among these is the need to minimize the error on the luminosity measurement while avoiding the intense beam background at small angles. In this study the geometrical parameters are optimized for the best performance of the calorimeter. In addition, the suppression of physics background to Bhabha scattering is investigated and a set of selection cuts is introduced.

  8. Mechanical integration studies for the CLIC vertex and inner tracking detectors

    CERN Document Server

    Villarejo Bermudez, M.A.; Gerwig, H.

    2015-01-01

    Since the publication of the CLIC Conceptual Design Report, work has proceeded in order to establish a preliminary mechanical design for the innermost CLIC detector region. This note proposes a design for the main Carbon-Fibre Reinforced Polymer (CFRP) structural elements of the inner detectors, for the beam pipe and their supports. It also describes an assembly sequence for the integration of the sensors and the mechanical components. Mechanical simulations of different structural elements and a material budget estimation are appended. Details of a proposed cabling layout for all the subdetectors are included.

  9. Progress on modelling of the thermo-mechanical behavior of the CLIC two-beam module

    CERN Document Server

    Raatikainen, R; Niinikoski, T; Riddone, G

    2011-01-01

    under study, imposes micrometer mechanical stability of the 2-m long two-beam modules, the shortest repetitive elements of the main linacs. These modules will be exposed to variable high power dissipation during operation resulting in mechanical distortions in and between module components. The stability of the CLIC module will be tested in laboratory conditions at CERN in a full-scale prototype module. In this paper, the FEA model developed for CLIC prototype module is described. The thermal and structural results for the new module configuration are presented considering the thermo-mechanical behavior of the CLIC collider in its primary operation modes. These results will be compared to the laboratory measurements to be done during 2011 and 2012 with the full-scale prototype module. The experimental results will allow for better understanding of the module behaviour and they will be propagated back to the present thermo-mechanical model.

  10. Structures and magnetism of mono-palladium and mono-platinum doped Au25(PET)18 nanoclusters.

    Science.gov (United States)

    Tian, Shubo; Liao, Lingwen; Yuan, Jinyun; Yao, Chuanhao; Chen, Jishi; Yang, Jinlong; Wu, Zhikun

    2016-08-01

    Herein we report three important results of widespread interest, which are (1) the crystal structure of [Au24Pt(PET)18](0), (2) the crystal structure of [Au24Pd(PET)18](0) and (3) the main source of magnetism in [Au25(PET)18](0).

  11. Overview of the CLIC detector and its physics potential

    CERN Document Server

    Strom, Lars Rickard

    2016-01-01

    The CLIC detector and physics study (CLICdp) is an international collaboration that investigates the physics potential of the Compact Linear Collider (CLIC). CLIC is a high-energy electron-positron collider under development, aiming for centre-of-mass energies from a few hundred GeV to 3 TeV. In addition to physics studies based on full Monte Carlo simulations of signal and background processes, CLICdp performs cutting-edge hardware R&D. In this contribution CLICdp will present recent results from physics prospect studies, emphasising Higgs studies. Additionally the new CLIC detector model and the recently updated CLIC baseline staging scenario will be presented.

  12. CLICdp Overview. Overview of physics potential at CLIC

    Directory of Open Access Journals (Sweden)

    Levy Aharon

    2015-01-01

    Full Text Available CLICdp, the CLIC detector and physics study, is an international collaboration presently composed of 23 institutions. The collaboration is addressing detector and physics issues for the future Compact Linear Collider (CLIC, a high-energy electron-positron accelerator which is one of the options for the next collider to be built at CERN. Precision physics under challenging beam and background conditions is the key theme for the CLIC detector studies. This leads to a number of cutting-edge R&D activities within CLICdp. The talk includes a brief introduction to CLIC, accelerator and detectors, hardware R&D as well as physics studies at CLIC.

  13. CLIC quadrupole stabilization and nano-positioning

    CERN Document Server

    Collette, C; Artoos, K; Fernandez Carmona, P; Guinchard, M; Hauviller, C

    2010-01-01

    In the Compact LInear Collider (CLIC) currently under study, electrons and positrons will be accelerated in two linear accelerators to collide at the interaction point with an energy of 0.5- 3 TeV. This machine is constituted of a succession of accelerating structures, used to accelerate the beams of particles, and electromagnets (quadrupoles) used to focus the beams. In order to ensure good performances, the quadrupoles have to be extremely stable. Additionally, they should also have the capability to move by steps of some tens of nanometers every 20 ms with a precision of +/- 1nm. This paper proposes a holistic approach to fulfill alternatively both requirements using the same device. The concept is based on piezoelectric hard mounts to isolate the quadrupoles from the ground vibrations in the sensitive range between 1 and 20 Hz, and to provide nano-positioning capabilities. It is also shown that this strategy ensures robustness to external forces (acoustic noise, water flow for the cooling, air flow for th...

  14. CLIC-ACM: Acquisition and Control System

    CERN Document Server

    Bielawski, B; Magnoni, S

    2014-01-01

    CLIC [1] (Compact Linear Collider) is a world-wide collaboration to study the next terascale lepton collider, relying upon a very innovative concept of two-beamacceleration. In this scheme, the power is transported to the main accelerating structures by a primary electron beam. The Two Beam Module (TBM) is a compact integration with a high filling factor of all components: RF, Magnets, Instrumentation, Vacuum, Alignment and Stabilization. This paper describes the very challenging aspects of designing the compact system to serve as a dedicated Acquisition & Control Module (ACM) for all signals of the TBM. Very delicate conditions must be considered, in particular radiation doses that could reach several kGy in the tunnel. In such severe conditions shielding and hardened electronics will have to be taken into consideration. In addition, with more than 300 ADC&DAC channels per ACM and about 21000 ACMs in total, it appears clearly that power consumption will be an important issue. It is also obvious that...

  15. Light-flavor squark reconstruction at CLIC

    CERN Document Server

    AUTHOR|(SzGeCERN)548062; Weuste, Lars

    2015-01-01

    We present a simulation study of the prospects for the mass measurement of TeV-scale light- flavored right-handed squark at a 3 TeV e+e collider based on CLIC technology. The analysis is based on full GEANT4 simulations of the CLIC_ILD detector concept, including Standard Model physics backgrounds and beam-induced hadronic backgrounds from two- photon processes. The analysis serves as a generic benchmark for the reconstruction of highly energetic jets in events with substantial missing energy. Several jet finding algorithms were evaluated, with the longitudinally invariant kt algorithm showing a high degree of robustness towards beam-induced background while preserving the features typically found in algorithms developed for e+e- collisions. The presented study of the reconstruction of light-flavored squarks shows that for TeV-scale squark masses, sub-percent accuracy on the mass measurement can be achieved at CLIC.

  16. Laser wire emittance measurement line AT CLIC

    CERN Document Server

    Garcia, H; Blair, G A; Aumeyr, T; Schulte, D; Stulle, F

    2011-01-01

    A precise measurement of the transverse beam size and beam emittances upstream of the final focus is essential for ensuring the full luminosity at future linear colliders. A scheme for the emittance measurements at the RTML line of the CLIC using laser-wire beam profile monitors is described. A lattice of the measurement line is discussed and results of simulations of statistical errors and of their impact on the accuracy of the emittance reconstruction are given. Laser wire systems suitable for CLIC and their main characteristics are discussed.

  17. Physics highlights at ILC and CLIC

    CERN Document Server

    Lukić, Strahinja

    2015-01-01

    In this lecture, the physics potential for the e+e- linear collider experiments ILC and CLIC is reviewed. The experimental conditions are compared to those at hadron colliders and their intrinsic value for precision experiments, complementary to the hadron colliders, is discussed. The detector concepts for ILC and CLIC are outlined in their most important aspects related to the precision physics. Highlights from the physics program and from the benchmark studies are given. It is shown that linear colliders are a promising tool, complementing the LHC in essential ways to test the Standard Model and to search for new physics.

  18. Optimization of the CLIC Baseline Collimation System

    Energy Technology Data Exchange (ETDEWEB)

    Resta-Lopez, Javier; /Oxford U., JAI; Angal-Kalinin, Deepa; /Daresbury; Fernandez-Hernando, Juan; /Daresbury; Jackson, Frank; /Daresbury; Dalena, Barbara; /CERN; Schulte, Daniel; /CERN; Tomas, Rogelio; /CERN; Seryi, Andrei; /SLAC

    2012-07-06

    Important efforts have recently been dedicated to the improvement of the design of the baseline collimation system of the Compact Linear Collider (CLIC). Different aspects of the design have been optimized: the transverse collimation depths have been recalculated in order to reduce the collimator wakefield effects while maintaining a good efficiency in cleaning the undesired beam halo; the geometric design of the spoilers have also been reviewed to minimize wakefields; in addition, the optics design have been polished to improve the collimation efficiency. This paper describes the current status of the CLIC collimation system after this optimization.

  19. Status of the CLIC Beam Delivery System

    CERN Document Server

    Tomás, R; Resta López, J; Rumolo, G; Schulte, D; Schuler, P; Bolzon, B; Brunetti, L; Brunetti, L; Geffroy, N; Jeremie, A; Seryi, A; Angal-Kalinin, D; Jackson, F

    2010-01-01

    The CLIC Beam Delivery System (BDS) is experiencing the careful revision from a large number of world wide experts. This was particularly enhanced by the successful CLIC’08 workshop held at CERN. Numerous new ideas, improvements and critical points are arising, establishing the path towards the Conceptual Design Report by 2010.

  20. CLIC preparations go up a notch

    CERN Multimedia

    2007-01-01

    The Compact Linear Collider gears up for post-LHC physics with an international workshop. A schematic diagram of CLIC.In June CERN gained a new building: number 2010. And as chance would have it, this is more than just a number to its new residents. By the year 2010, teams working at the new CLIC Experimental Area, along with the already established CLIC Test Facility Three (CTF3), hope to have demonstrated the feasibility of the Compact Linear Collider and, depending on results from the LHC, embark on its final design and proposal. A workshop on 16t-18 October brought people from all around the world to CERN to exchange ideas and hear how the ambitious project is progressing. CLIC is a project that aims to extend lepton collider technology to multi-TeV energy physics, colliding leptons with a centre-of-mass-energy up to 3TeV, more than ten times the energy of the LEP. This is only possible in a linear collider, where no energy is lo...

  1. Geometric calibration between PET scanner and structured light scanner

    DEFF Research Database (Denmark)

    Kjer, Hans Martin; Olesen, Oline Vinter; Paulsen, Rasmus Reinhold;

    2011-01-01

    Head movements degrade the image quality of high resolution Positron Emission Tomography (PET) brain studies through blurring and artifacts. Manny image reconstruction methods allows for motion correction if the head position is tracked continuously during the study. Our method for motion trackin...

  2. Cherenkov Fibers for Beam Loss Monitoring at the CLIC Two Beam Module

    CERN Document Server

    van Hoorne, Jacobus Willem; Holzer, E B

    The Compact Linear Collider (CLIC) study is a feasibility study aiming at a nominal center of mass energy of 3TeV and is based on normal conducting travelling-wave accelerating structures, operating at very high field gradients of 100 MV/m. Such high fields require high peak power and hence a novel power source, the CLIC two beam system, has been developed, in which a high intensity, low energy drive beam (DB) supplies energy to a high energy, low intensity main beam (MB). At the Two Beam Modules (TBM), which compose the 2x21km long CLIC main linac, a protection against beam losses resulting from badly controlled beams is necessary and particularly challenging, since the beam power of both main beam (14 MW) and drive beam (70 MW) is impressive. To avoid operational downtimes and severe damages to machine components, a general Machine Protection System (MPS) scheme has been developed. The Beam Loss Monitoring (BLM) system is a key element of the CLIC machine protection system. Its main role will be to detect p...

  3. R&D Challenges of a CLIC Vertex Detector

    CERN Document Server

    van der Kraaij, E

    2010-01-01

    The Compact Linear Collider (CLIC) is a concept for an electron-positron collider with a center- of-mass energy of up to 3 TeV. Given the unprecedented experimental conditions at CLIC none of the technologies available today can fulfill all requirements set for the vertex detector. At the conference these conditions and the challenges they pose for the R&D of a CLIC vertex detector were presented.

  4. The CLIC BDS Towards the Conceptual Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Tomas, Rogelio; /CERN; Dalena, Barbara; /CERN; Marin, Eduardo; /CERN; Schulte, Daniel; /CERN; Zamudio, Guillermo; /CERN; Angal-Kalinin, Deepa; /Cockcroft Inst. Accel. Sci. Tech.; Fernandez-Hernando, Juan; /Cockcroft Inst. Accel. Sci. Tech.; Jackson, Frank; /Cockcroft Inst. Accel. Sci. Tech.; Resta-Lopez, Javier; /Oxford U., JAI; Seryi, Andrei; /SLAC

    2012-07-05

    The CLIC Conceptual Design Report (CDR) must be ready by 2010. This paper aims at addressing all the critical points of the CLIC Beam Delivery Systems (BDS) to be later implemented in the CDR. This includes risk evaluation and possible solutions to a number of selected points. The smooth and practical transition between the 500 GeV CLIC and the design energy of 3 TeV is also studied.

  5. ISSUES AND FEASIBILITY DEMONSTRATION OF CLIC SUPPORTING SYSTEM CHAIN ACTIVE PRE-ALIGNMENT USING A MULTI-MODULE TEST SETUP (MOCK-UP)

    CERN Document Server

    Sosin, Mateusz

    2016-01-01

    The implementation study of the CLIC (Compact LInear Collider) is under way at CERN with a focus on the challenging issues. The pre-alignment precision and accuracy requirements are part of these technical challenges: the permissible transverse position errors of the linac components are typically 14 micrometers over sliding windows of 200m. To validate the proposed methods and strategies, the Large Scale Metrology section at CERN has performed campaigns of measurements on the CLIC Two Beam Test Modules, focusing inter alia on the alignment performance of the CLIC “snake”- girders configuration and the Main Beam Quadrupoles supporting structures. This paper describes the activities and results of tests which were performed on the test mock-up for the qualification of the CLIC supporting system chain for active pre-alignment. The lessons learnt (“know how”), the issues encountered in the girder position determination as well as the behaviour of the mechanical components are presented.

  6. Neuronal pathology in deep grey matter structures: a multimodal imaging analysis combining PET and MRI

    Energy Technology Data Exchange (ETDEWEB)

    Bosque-Freeman, L.; Leroy, C.; Galanaud, D.; Sureau, F.; Assouad, R.; Tourbah, A.; Papeix, C.; Comtat, C.; Trebossen, R.; Lubetzki, C.; Delforge, J.; Bottlaender, M.; Stankoff, B. [Serv. Hosp. Frederic Joliot, Orsay (France)

    2009-07-01

    Objective: To assess neuronal damage in deep gray matter structures by positron emission tomography (PET) using [{sup 11}C]-flumazenil (FMZ), a specific central benzodiazepine receptor antagonist, and [{sup 18}F]-fluorodeoxyglucose (FDG), which reflects neuronal metabolism. To compare results obtained by PET and those with multimodal magnetic resonance imaging (MRI). Background: It is now accepted that neuronal injury plays a crucial role in the occurrence and progression of neurological disability in multiple sclerosis (MS). To date, available MRI techniques do not specifically assess neuronal damage, but early abnormalities, such as iron deposition or atrophy, have been described in deep gray matter structures. Whether those MRI modifications correspond to neuronal damage remains to be further investigated. Materials and methods: Nine healthy volunteers were compared to 10 progressive and 9 relapsing remitting (RR) MS patients. Each subject performed two PET examinations with [{sup 11}C]-FMZ and [{sup 18}F]-FDG, on a high resolution research tomograph dedicated to brain imaging (Siemens Medical Solution, spatial resolution of 2.5 mm). Deep gray matter regions were manually segmented on T1-weighted MR images with the mutual information algorithm (www.brainvisa.info), and co-registered with PET images. A multimodal MRI including T1 pre and post gadolinium, T2-proton density sequences, magnetization transfer, diffusion tensor, and protonic spectroscopy was also performed for each subject. Results: On PET with [{sup 11}C]-FMZ, there was a pronounced decrease in receptor density for RR patients in all deep gray matter structures investigated, whereas the density was unchanged or even increased in the same regions for progressive patients. Whether the different patterns between RR and progressive patients reflect distinct pathogenic mechanisms is currently investigated by comparing PET and multimodal MRI results. Conclusion: Combination of PET and multimodal MR imaging

  7. Estrutura da cadeia reversa: "caminhos" e "descaminhos" da embalagem PET Structure of the reverse chain: "ways" of PET packing

    Directory of Open Access Journals (Sweden)

    Sylmara Lopes Francelino Gonçalves-Dias

    2006-12-01

    Full Text Available O trabalho propõe-se a discutir as possibilidades, limites e desafios da reciclagem de PET - Politereftalato de Etileno. Como fundamentação teórico-conceitual, recorre à discussão sobre a natureza e o alcance da logística reversa, analisando as estratégias para estruturação da cadeia de reciclagem. A pesquisa é de caráter exploratório, com adoção de diferentes estratégias para a coleta de dados, envolvendo fontes secundárias produzidas por órgãos públicos, instituições especializadas e mídia, e ainda entrevistas semi-estruturadas com especialistas na área. Os resultados apontam que múltiplos atores estão envolvidos na estrutura da cadeia reversa do PET e que, apesar do avanço no volume de reciclagem, nenhum dos setores, seja público ou privado, consegue individualmente organizar-se para o alcance da efetividade operacional e ambiental desejável no cenário brasileiro. O alcance de bons resultados depende, sobretudo, do investimento nos dois extremos da cadeia reversa: na coleta seletiva e no mercado para o produto reciclado.The work discuss the possibilities, limits and challenges of the recycling of PET packing in the Brazilian case. The authors analyze the nature and the function of the reverse logistics and its strategies for articulation of the recycling chain. The research is based in the exploratory methodological approach, with adoption of different strategies for the collection of data, involving secondary sources produced by public institutions, specialized organizations and media, and still, interviews semi-structured with specialists in the area. The results point that the Brazilian public and private sectors doesn’t get to organize this activity in the desirable environmental scale. Good performances in the PET packing reverse chain depends on investing in the selective collection and in the market for the recycled products.

  8. The CLIC Post-Collision Line

    CERN Document Server

    Gschwendtner, E; Elsener, K; Sailer, A; Uythoven, J; Appleby, R B; Salt, M; Ferrari, A; Ziemann, V

    2010-01-01

    The 1.5 TeV CLIC beams, with a total power of 14 MW per beam, are disrupted at the interaction point due to the very strong beam-beam effect. As a result, some 3.5 MW reach the main dump in form of beamstrahlung photons. About 0.5 MW of e+e- pairs with a very broad energy spectrum need to be disposed of along the post-collision line. The conceptual design of this beam line will be presented. Emphasis will be on the optimization studies of the CLIC post-collision line design with respect to the energy deposition in windows, dumps and absorbers, on the design of the luminosity monitoring for a fast feedback to the beam steering and on the background conditions for the luminosity monitoring equipment.

  9. CLIC Post-Collision Line Luminosity Monitoring

    CERN Document Server

    Appleby, R B; Deacon, L; Geschwendtner, E

    2011-01-01

    The CLIC post collision line is designed to transport the un-collided beams and the products of the collided beams with a total power of 14MW to the main beam dump. Full Monte Carlo simulation has been done for the description of the CLIC luminosity monitoring in the post collision line. One method of the luminosity diagnostic is based on the detection of high energy muons produced by beamstrahlung photons in the main beam dump. The disrupted beam and the beamstrahlung photons produce at the order of 106 muons per bunch crossing per cm2, with energies higher than 10 GeV. Threshold Cherenkov counters are considered after the beam dump for the detection of these high energy muons. Another method for luminosity monitoring is presented using the direct detection of the beamstrahlung photons.

  10. Structural features and relaxation properties of PET/PC blends containing impact strength modifier and chain extender

    Directory of Open Access Journals (Sweden)

    2009-10-01

    Full Text Available It has been investigated how methylene diphenyl diisocyanate (MDI influences the morphology, rheological, mechanical and relaxation properties, as well as PET crystallizability, of PET/PC/(PP/EPDM ternary blends produced by the reactive extrusion process. It appears that irrespective of phase structure of the blends, MDI causes a rise in melt viscosity (decreased MFI-values of the material which is the result of an increased molecular weight of the macromolecules; PET crystallization becomes retarded. MDI improves compatibility between PET and PC in PET/PC/(PP/EPDM ternary blends. Addition of MDI leads to higher values of the dynamic shear modulus for PET high elastic state (in the temperature range between Tg PET and cool crystallization temperature of PET; the PET cool crystallization and melt crystallization processes become retarded; the PET and PC glass transition temperatures approach one another. MDI has been shown not to influence significantly the blend morphology or the character of interaction between the PP/EPDM disperse phase and PET/PC blend matrix.

  11. 3D quantification of soil structure and functioning based on PET and CT scanning techniques

    DEFF Research Database (Denmark)

    Garbout, Amin

    . The processed measurements show some expected and a few unexpected effects (or lack of effects) on different characteristics of soil structure. The combination of CT and PET scanning in an air plant soil controller system revealed some very interesting research possibilities. Interactions between soil structure...

  12. CLIC Telescope optimization with ALLPIX simulation

    CERN Document Server

    Qi, Wu

    2015-01-01

    A simulation study of CLIC-EUDET telescope resolution with MIMOSA 26 as reference sensors under DESY (5.6 GeV electron beam) and CERN-SPS (120-180 GeV pion^{-} beam) conditions. During the study, a virtual DUT sensor with cylindrical sensing area was defined and used with ALLPIX software. By changing the configuration of telescope, some results for DESY's setup were found agreeing with the theoretical calculation.

  13. Submicron multi-bunch BPM for CLIC

    Energy Technology Data Exchange (ETDEWEB)

    Schmickler, H.; Soby, L.; /CERN; Lunin, A.; Solyak, N.; Wendt, M.; /Fermilab

    2010-08-01

    A common-mode free cavity BPM is currently under development at Fermilab within the ILC-CLIC collaboration. This monitor will be operated in a CLIC Main Linac multi-bunch regime, and needs to provide both, high spatial and time resolution. We present the design concept, numerical analysis, investigation on tolerances and error effects, as well as simulations on the signal response applying a multi-bunch stimulus. The proposed CERN linear collider (CLIC) requires a very precise measurement of beam trajectory to preserve the low emittance when transporting the beam through the Main Linac. An energy chirp within the bunch train will be applied to measure and minimize the dispersion effects, which require high resolution (in both, time and space) beam position monitors (BPM) along the beam-line. We propose a low-Q waveguide loaded TM{sub 110} dipole mode cavity as BPM, which is complemented by a TM{sub 010} monopole mode resonator of same resonant frequency for reference signal purposes. The design is based on a well known TM{sub 110} selective mode coupling idea.

  14. Silicon pixel R&D for CLIC

    CERN Document Server

    AUTHOR|(SzGeCERN)754303

    2016-01-01

    Challenging detector requirements are imposed by the physics goals at the future multi-TeV e+e- Compact Linear Collider (CLIC). A single point resolution of 3μm for the vertex detector and 7μm for the tracker is required. Moreover, the CLIC vertex detector and tracker need to be extremely light weighted with a material budget of 0.2 % X0 per layer in the ver- tex detector and 1-2%X0 in the tracker. A fast time slicing of 10ns is further required to suppress background from beam-beam interactions. A wide range of sensor and readout ASIC technologies are investigated within the CLIC silicon pixel R&D effort. Various hybrid planar sensor assemblies with a pixel size of 25x25μm2 and 55x55μm2 have been produced and characterised by laboratory measurements and during test-beam campaigns. Experimental and simulation results for thin (50μm-500μm) slim edge and active-edge planar, and High-Voltage CMOS sensors hybridised to various readout ASICs (Timepix, Timepix3, CLICpix) are presented.

  15. Silicon pixel R&D for CLIC

    Science.gov (United States)

    Munker, M.

    2017-01-01

    Challenging detector requirements are imposed by the physics goals at the future multi-TeV e+ e‑ Compact Linear Collider (CLIC). A single point resolution of 3 μm for the vertex detector and 7 μm for the tracker is required. Moreover, the CLIC vertex detector and tracker need to be extremely light weighted with a material budget of 0.2% X0 per layer in the vertex detector and 1–2% X0 in the tracker. A fast time slicing of 10 ns is further required to suppress background from beam-beam interactions. A wide range of sensor and readout ASIC technologies are investigated within the CLIC silicon pixel R&D effort. Various hybrid planar sensor assemblies with a pixel size of 25×25 μm2 and 55×55 μm2 have been produced and characterised by laboratory measurements and during test-beam campaigns. Experimental and simulation results for thin (50 μm–500 μm) slim edge and active-edge planar, and High-Voltage CMOS sensors hybridised to various readout ASICs (Timepix, Timepix3, CLICpix) are presented.

  16. Impact of Dynamic Magnetic fields on the CLIC Main Beam

    CERN Document Server

    Snuverink, J; Jach, C; Jeanneret, JB; Schulte, D; Stulle, F

    2010-01-01

    The Compact Linear Collider (CLIC) accelerator has strong precision requirements on the position of the beam. The beam position will be sensitive to external dynamic magnetic fields (stray fields) in the nanotesla regime. The impact of these fields on the CLIC main beam has been studied by performing simulations on the lattices and tolerances have been determined. Several mitigation techniques will be discussed.

  17. Simulation of Beam-Beam Background at CLIC

    CERN Document Server

    Sailer, A

    2010-01-01

    The dense beams used at CLIC to achieve a high luminosity will cause a large amount of background particles through beam-beam interactions. Generator level studies with GUINEAPIG and full detector simulation studies with an ILD based CLIC detector have been performed to evaluate the amount of beam-beam back- ground hitting the vertex detector.

  18. The physics benchmark processes for the detector performance studies used in CLIC CDR Volume 3

    CERN Document Server

    Allanach, B.J.; Desch, K.; Ellis, J.; Giudice, G.; Grefe, C.; Kraml, S.; Lastovicka, T.; Linssen, L.; Marschall, J.; Martin, S.P.; Muennich, A.; Poss, S.; Roloff, P.; Simon, F.; Strube, J.; Thomson, M.; Wells, J.D.

    2012-01-01

    This note describes the detector benchmark processes used in volume 3 of the CLIC conceptual design report (CDR), which explores a staged construction and operation of the CLIC accelerator. The goal of the detector benchmark studies is to assess the performance of the CLIC ILD and CLIC SiD detector concepts for different physics processes and at a few CLIC centre-of-mass energies.

  19. Structured light 3D tracking system for measuring motions in PET brain imaging

    DEFF Research Database (Denmark)

    Olesen, Oline Vinter; Jørgensen, Morten Rudkjær; Paulsen, Rasmus Reinhold

    2010-01-01

    Patient motion during scanning deteriorates image quality, especially for high resolution PET scanners. A new proposal for a 3D head tracking system for motion correction in high resolution PET brain imaging is set up and demonstrated. A prototype tracking system based on structured light...... with a DLP projector and a CCD camera is set up on a model of the High Resolution Research Tomograph (HRRT). Methods to reconstruct 3D point clouds of simple surfaces based on phase-shifting interferometry (PSI) are demonstrated. The projector and camera are calibrated using a simple stereo vision procedure...

  20. Fiducialisation and initial alignment of CLIC component with micrometric accuracy

    CERN Document Server

    Mainaud Durand, Helene; Buzio, Marco; Caiazza, Domenico; Catalan Lasheras, Nuria; Cherif, Ahmed; Doytchinov, Iordan Petrov; Fuchs, Jean-Frederic; Gaddi, Andrea; Galindo Munoz, Natalia; Gayde, Jean-Christophe; Kamugasa, Solomon William; Modena, Michele; Novotny, Peter; Sanz, Claude; Severino, Giordana; Russenschuck, Stephan; Tshilumba, David; Vlachakis, Vasileios; Wendt, Manfred; Zorzetti, Silvia; CERN. Geneva. ATS Department

    2016-01-01

    We propose a new solution to fiducialise the three major components of the CLIC collider: quadrupoles, beam-position monitors (BPM), and accelerating structures (AS). This solution is based on the use of a copper-beryllium (CuBe) wire to locate the reference position, i.e. the symmetry axes of the components (their magnetic, respectively electromagnetic centre axis), and to determine their position in the common support assembly defining a local coordinate system, with respect to the fiducials. These alignment targets will be used later to align the support assembly in the tunnel. With such a method, several accelerator components of different types, supported by a dedicated adjustment system, can be simultaneously fiducialised and pre-aligned using the same wire, enabling a micrometric accuracy with help of a 3D coordinate measurement machine (CMM). Alternative solutions based on frequency scanning interferometry (FSI) and micro-triangulation are also under development, to perform such fiducialisation and in...

  1. Electro-Weak Fits at CLIC

    CERN Document Server

    De Curtis, S

    2002-01-01

    The aim of the future linear colliders is to extend the sensitivity to new physics beyond the reach of the LHC. Several models predict the existence of new vector resonances in the multi-TeV region. We review the existing limits on the masses of these new resonances from LEP/SLC and TEVATRON data and from the atomic parity violation measurements, in some specific models. We study the potential of a multi-TeV e+e- collider, such as CLIC, for the determination of their properties and nature.

  2. Conceptual Design for CLIC Gun Pulser

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Tao [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2016-01-08

    The Compact Linear Collider (CLIC) is a proposed future electron-positron collider, designed to perform collisions at energies from 0.5 to 5 TeV, with a nominal design optimized for 3 TeV (Dannheim, 2012). The Drive Beam Accelerator consists of a thermionic DC gun, bunching section and an accelerating section. The thermionic gun needs deliver a long (~143us) pulse of current into the buncher. A pulser is needed to drive grid of the gun to generate a stable current output. This report explores the requirements of the gun pulser and potential solutions to regulate grid current.

  3. Thermo-Mechanical tests for the CLIC two-beam module study

    CERN Document Server

    Xydou, A; Riddone, G; Daskalaki, E

    2014-01-01

    The luminosity goal of CLIC requires micron level precision with respect to the alignment of the components on its two-meter long modules, composing the two main linacs. The power dissipated inside the module components introduces mechanical deformations affecting their alignment and therefore the resulting machine performance. Several two-beam prototype modules must be assembled to extensively measure their thermo-mechanical behavior under different operation modes. In parallel, the real environmental conditions present in the CLIC tunnel should be studied. The air conditioning and ventilation system providing specified air temperature and flow has been installed in the dedicated laboratory. The power dissipation occurring in the modules is being reproduced by the electrical heaters inserted inside the RF structure mock-ups and the quadrupoles. The efficiency of the cooling systems is being verified and the alignment of module components is monitored. The measurement results will be compared to finite elemen...

  4. Status of vertex and tracking detector R&D at CLIC

    CERN Document Server

    AUTHOR|(SzGeCERN)754272

    2015-01-01

    The physics aims at the future CLIC high-energy linear e+e- collider set very high precision requirements on the performance of the vertex and tracking detectors. Moreover, these detectors have to be well adapted to the experimental conditions, such as the bunch train structure of the beam and the presence of beam-induced backgrounds. The principal challenges are: a point resolution of a few micron, ultra-low mass (~0.2% X0 per layer for the inner vertex region), very low power dissipation (compatible with air-flow cooling in the inner vertex region) and pulsed power operation, complemented with ~10 ns time stamping capabilities. An overview of the R&D program for pixel and tracking detectors at CLIC will be presented, including recent results on an innovative hybridisation concept based on capacitive coupling between active sensors (HV-CMOS) and readout ASICs (CLICpix).

  5. Study of the Thermo-Mechanical Behavior of the CLIC Two-Beam Modules

    CERN Document Server

    Rossi, F; Riddone, G; Österberg, K; Kossyvakis, I; Gudkov, D; Samochkine, A

    2013-01-01

    The final luminosity target of the Compact LInear Collider (CLIC) imposes a micron-level stability requirement on the two-meter repetitive two-beam modules constituting the main linacs. Two-beam prototype modules are being assembled to extensively study their thermo-mechanical behaviour under different operation modes. The power dissipation occurring in the modules will be reproduced and the efficiency of the corresponding cooling systems validated. At the same time, the real environmental conditions present in the CLIC tunnel will be studied. Air conditioning and ventilation systems have been installed in the dedicated laboratory. The air temperature will be changed from 20 to 40°C, while the air flow rate will be varied up to 0.8 m/s. During all experimental tests, the alignment of the RF structures will be monitored to investigate the influence of power dissipation and air temperature on the overall thermo-mechanical behaviour. \

  6. Thermo-mechanical modelling and experimental validation of CLIC prototype module type 0

    CERN Document Server

    Kortelainen, Lauri; Koivurova, Hannu; Riddone, Germana; Österberg, Kenneth

    Micron level stability of the two-meter repetitive modules constituting the two main linacs is one of the most important requirements to achieve the luminosity goal for the Compact Linear Collider. Structural deformations due to thermal loads and related to the RF power dissipated inside the modules affect the alignment of the linacs and therefore the resulting luminosity performance. A CLIC prototype module has been assembled in a dedicated laboratory and a thermal test program has been started in order to study its thermo-mechanical behaviour. This thesis focuses on the finite elements modelling of the first CLIC prototype module 0. The aim of the modelling is to examine the temperature distributions and the resulting deformations of the module in different operating conditions defined in the thermal test program. The theoretical results have been compared to the experimental ones; the comparison shows that the results are in good agreement both for the thermal behaviour of the module and for the resulting ...

  7. CLIC crab cavity final report

    CERN Document Server

    Burt, G et al

    2013-01-01

    A high gradient 12 GHz, normal‐conducting travelling‐wave structure, with a high group‐velocity to minimise the effects of beam loading, has been developed. Appropriate input coupler and wakefield damping processes have been incorporated and two ‘undamped’ structures have been fabricated, one in the UK by Shakespeare Engineering Ltd and the other by VDL at CERN. Systematic high gradient tests are planned at SLAC and CERN, to study breakdown differences between deflecting and accelerating structures.

  8. Combined Fits of CLIC Higgs Results for the Snowmass Process

    CERN Document Server

    Simon, F; Roloff, P

    2013-01-01

    This note presents three combined fits of CLIC Higgs physics results, a model- independent fit based on minimal assumptions and two model-dependent fits assuming that the total width is described by the sum of nine (seven) different visible final states with coupling parameters given by the deviation of the re- spective partial widths from their SM values. The input values are a snapshot of the CLIC Higgs analyses as of September 2013. The results demonstrate the capabilities of the full three-stage CLIC physics program for a precise ex- ploration of the Higgs sector.

  9. CLIC vertex detector R&D

    CERN Document Server

    Redford, S

    2014-01-01

    In order to achieve its primary objectives of heavy-flavour tagging and tau lepton identification, the CLIC vertex detector must precisely reconstruct displaced vertices. This re- quires accurate determination of the impact parameter and charge of tracks originating from the secondary vertex. Excellent spatial resolution must therefore be provided down to low polar angles, whilst maintaining low occupancy, low mass and low power dissipation. These requirements chal- lenge current technological limits, and demand a broad programme of R&D. A detector concept is currently under development, comprising a hybrid pixel detector of small-pitch readout ASICs implemented in 65nm CMOS technology (CLICpix) combined with ultra-thin sensors. The read- out chips are low-power, and power-pulsing is used to reduce further their power dissipation. This enables a forced gas cooling system in the vertex detector region. In this paper, the CLIC vertex detector requirements are reviewed and the current status of R&D on se...

  10. Beam dynamic simulations of the CLIC crab cavity and implications on the BDS

    Energy Technology Data Exchange (ETDEWEB)

    Shinton, I.R.R., E-mail: ian.shinton@stfc.ac.uk [School of Physics and Astronomy, University of Manchester, Manchester (United Kingdom); Cockcroft Institute of Accelerator Science and Technology, Daresbury (United Kingdom); Burt, G. [Engineering Department, Lancaster University, Lancaster (United Kingdom); Cockcroft Institute of Accelerator Science and Technology, Daresbury (United Kingdom); Glasman, C.J.; Jones, R.M. [School of Physics and Astronomy, University of Manchester, Manchester (United Kingdom); Cockcroft Institute of Accelerator Science and Technology, Daresbury (United Kingdom); Wolski, A. [Department of Physics, University of Liverpool, Liverpool (United Kingdom); Cockcroft Institute of Accelerator Science and Technology, Daresbury (United Kingdom)

    2011-11-21

    The Compact Linear Collider (CLIC) is a proposed electron positron linear collider design aiming to achieve a centre of mass energy of up to 3 TeV. The main accelerating structures in CLIC operate at an X-band frequency of 11.994 GHz with an accelerating gradient of 100 MV/m. The present design requires the beams to collide at a small crossing angle of 10 mrad per line giving a resultant overall crossing angle of 20 mrad. Transverse deflecting cavities, referred to as 'Crab cavities', are installed in the beam delivery system (BDS) of linear collider designs in order to ensure the final luminosity at the interaction point (IP) is comparable to that in a head on collision. We utilise the beam tracking code PLACET combined with the beam-beam code GUINEA-PIG to calculate the resulting luminosity at the IP. We follow a similar tuning procedure to that used for the design of the ILC crab cavities and anitcrab cavities. However an unexpected loss in luminosity of 10% was observed for the 20 mrad design was observed. It was discovered that the action of the crab cavities can affect the geometric aberrations resulting from the sextupoles used to correct chromatic effects in the beam delivery system. This has direct consequences regarding the design of the present CLIC BDS.

  11. Summary of the BDS and MDI CLIC08 Working Group

    CERN Document Server

    Tomás, R; Ahmed, I; Ambatu, PK; Angal-Kalinin, D; Barlow, R; Baud, J P; Bolzon, B; Braun, H; Burkhardt, H; Burt, GC; Corsini, R; Dalena, B; Dexter, AC; Dolgashev, V; Elsener, K; Fernandez Hernando, JL; Gaillard, G; Geffroy, N; Jackson, F; Jeremie, A; Jones, RM; McIntosh, P; Moffeit, K; Peltier, F; Resta-López, J; Rumolo, G; Schulte, D; Seryi, A; Toader, A; Zimmermann, F

    2008-01-01

    This note summarizes the presentations held within the Beam Delivery System and Machine Detector Interface working group of the CLIC08 workshop. The written contributions have been provided by the presenters on a voluntary basis.

  12. CLIC BDS Tuning, Alignment and Feedbacks Integrated Simulations

    CERN Document Server

    Dalena, B; Schulte, D; Snuverink, J; Tomas, R; Jones, J; Latina, A; Resta, J

    2010-01-01

    The CLIC BDS tuning, alignment and feedbacks studies have been typically performed independently and only over particular sections of the BDS. An effort is being put to integrate all these procedures to realistically evaluate the luminosity performance.

  13. A high resolution cavity BPM for the CLIC Test Facility

    CERN Document Server

    Chritin, N; Soby, L; Lunin, A; Solyak, N; Wendt, M; Yakovlev, V

    2012-01-01

    In frame of the development of a high resolution BPM system for the CLIC Main Linac we present the design of a cavity BPM prototype. It consists of a waveguide loaded dipole mode resonator and a monopole mode reference cavity, both operating at 15 GHz, to be compatible with the bunch frequencies at the CLIC Test Facility. Requirements, design concept, numerical analysis, and practical considerations are discussed.

  14. A high resolution cavity BPM for the CLIC Test Facility

    Energy Technology Data Exchange (ETDEWEB)

    Chritin, N.; Schmickler, H.; Soby, L.; /CERN; Lunin, A.; Solyak, N.; Wendt, M.; Yakovlev, V.; /Fermilab

    2010-08-01

    In frame of the development of a high resolution BPM system for the CLIC Main Linac we present the design of a cavity BPM prototype. It consists of a waveguide loaded dipole mode resonator and a monopole mode reference cavity, both operating at 15 GHz, to be compatible with the bunch frequencies at the CLIC Test Facility. Requirements, design concept, numerical analysis, and practical considerations are discussed.

  15. CLICdet: The post-CDR CLIC detector model

    CERN Document Server

    Alipour Tehrani, Niloufar; Cure, Benoit; Dannheim, Dominik; Duarte Ramos, Fernando; Elsener, Konrad; Gaddi, Andrea; Gerwig, Hubert; Green, Steven; Grefe, Christian; Hynds, Daniel; Klempt, Wolfgang; Linssen, Lucie; Nikiforou, Nikiforos; Nurnberg, Andreas Matthias; Marshall, John Stuart; Petric, Marko; Redford, Sophie; Roloff, Philipp Gerhard; Sailer, Andre; Sefkow, Felix; Sicking, Eva; Siegrist, Nicolas; Simon, Frank Richard; Simoniello, Rosa; Spannagel, Simon; Sroka, Szymon Krzysztof; Strom, Lars Rickard; Weber, Matthias Artur

    2017-01-01

    A new model for the CLIC detector has been defined based on lessons learnt while working with the CDR detector models and after a series of simulation studies. The new model, dubbed "CLICdet", also incorporates the experience from various R&D activities linked to a future experiment at CLIC. This note describes the studies and thoughts leading to the new detector model, and gives details on all of its sub-detector systems.

  16. Co-Expression of Ezrin-CLIC5-Podocalyxin Is Associated with Migration and Invasiveness in Hepatocellular Carcinoma.

    Directory of Open Access Journals (Sweden)

    Teresita N J Flores-Téllez

    Full Text Available Prognostic markers are important for predicting the progression and staging of hepatocellular carcinoma (HCC. Ezrin (EZR and Podocalyxin (PODXL are proteins associated with invasion, migration and poor prognosis in various types of cancer. Recently, it has been observed that chloride intracellular channel 5 (CLIC5 forms a complex with EZR and PODXL and that it is required for podocyte structure and function. In this study, we evaluated the overexpression of EZR, PODXL and CLIC5 in HCC.The modified resistant hepatocyte model (MRHR, human biopsies and HCC cell lines (HepG2, Huh7 and SNU387 were used in this study. Gene and protein expression levels were evaluated in the MRHR by qRT-PCR, Western blot and immunohistochemistry analyses, and protein expression in the human biopsies was evaluated by immunohistochemistry. Protein expression in the HCC cell lines was evaluated by immunofluorescence and Western blot, also the migration and invasive abilities of Huh7 cells were evaluated using shRNA-mediated inhibition.Our results indicated that these genes and proteins were overexpressed in HCC. Moreover, when the expression of CLIC5 and PODXL was inhibited in Huh7 cells, we observed decreased migration and invasion.This study suggested that EZR, CLIC5 and PODXL could be biological markers to predict the prognosis of HCC and that these proteins participate in migration and invasion processes.

  17. Combined MRI-PET dissects dynamic changes in plant structures and functions.

    Science.gov (United States)

    Jahnke, Siegfried; Menzel, Marion I; van Dusschoten, Dagmar; Roeb, Gerhard W; Bühler, Jonas; Minwuyelet, Senay; Blümler, Peter; Temperton, Vicky M; Hombach, Thomas; Streun, Matthias; Beer, Simone; Khodaverdi, Maryam; Ziemons, Karl; Coenen, Heinz H; Schurr, Ulrich

    2009-08-01

    Unravelling the factors determining the allocation of carbon to various plant organs is one of the great challenges of modern plant biology. Studying allocation under close to natural conditions requires non-invasive methods, which are now becoming available for measuring plants on a par with those developed for humans. By combining magnetic resonance imaging (MRI) and positron emission tomography (PET), we investigated three contrasting root/shoot systems growing in sand or soil, with respect to their structures, transport routes and the translocation dynamics of recently fixed photoassimilates labelled with the short-lived radioactive carbon isotope (11)C. Storage organs of sugar beet (Beta vulgaris) and radish plants (Raphanus sativus) were assessed using MRI, providing images of the internal structures of the organs with high spatial resolution, and while species-specific transport sectoralities, properties of assimilate allocation and unloading characteristics were measured using PET. Growth and carbon allocation within complex root systems were monitored in maize plants (Zea mays), and the results may be used to identify factors affecting root growth in natural substrates or in competition with roots of other plants. MRI-PET co-registration opens the door for non-invasive analysis of plant structures and transport processes that may change in response to genomic, developmental or environmental challenges. It is our aim to make the methods applicable for quantitative analyses of plant traits in phenotyping as well as in understanding the dynamics of key processes that are essential to plant performance.

  18. CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis

    Directory of Open Access Journals (Sweden)

    Kanin Salao

    2016-05-01

    Full Text Available Intracellular chloride channel protein 1 (CLIC1 participates in inflammatory processes by regulating macrophage phagosomal functions such as pH and proteolysis. Here, we sought to determine if CLIC1 can regulate adaptive immunity by actions on dendritic cells (DCs, the key professional antigen presenting cells. To do this, we first generated bone marrow-derived DCs (BMDCs from germline CLIC1 gene-deleted (CLIC1−/− and wild-type (CLIC1+/+ mice, then studied them in vitro and in vivo. We found phagocytosis triggered cytoplasmic CLIC1 translocation to the phagosomal membrane where it regulated phagosomal pH and proteolysis. Phagosomes from CLIC1−/− BMDCs displayed impaired acidification and proteolysis, which could be reproduced if CLIC1+/+, but not CLIC1−/− cells, were treated with IAA94, a CLIC family ion channel blocker. CLIC1−/− BMDC displayed reduced in vitro antigen processing and presentation of full-length myelin oligodendrocyte glycoprotein (MOG and reduced MOG-induced experimental autoimmune encephalomyelitis. These data suggest that CLIC1 regulates DC phagosomal pH to ensure optimal processing of antigen for presentation to antigen-specific T-cells. Further, they indicate that CLIC1 is a novel therapeutic target to help reduce the adaptive immune response in autoimmune diseases.

  19. THERMAL ANALYSIS AND STRUCTURE STUDIES ON THE BLENDS OF LIQUID CRYSTALLINE COPOLYESTERS AND PET, PBT

    Institute of Scientific and Technical Information of China (English)

    XIE Ping; LU Daohui

    1987-01-01

    The apparent uniform blends of liquid crystalline aromatic copolyesters and semiflexible polyesters PET or PBT were obtained by mechanical mixing in the molten state within certain range of composition.The effects of blending with liquid crystalline components on the structure of homopolyester matrix were examined by thermal analysis and X-ray diffraction. These results suggest that the LC component in the blend may possibly be acting as a nucleating agent, or it may induce axial orientation of molecules promoting the local ordering of matrix. For the blends of PET, these influences mainly display in narrowing the width of cold crystalline peak and enhancing the main peak of x-ray diffraction; and for the blends of PBT, the pre-melting crystalline peak was enhanced.

  20. Silicon pixel R&D for the CLIC detector

    CERN Document Server

    Hynds, Daniel

    2016-01-01

    The physics aims at the future CLIC high-energy linear e+e collider set very high precision requirements on the performance of the vertex and tracking detectors. Moreover, these detectors have to be well adapted to the experimental conditions, such as the time structure of the collisions and the presence of beam-induced backgrounds. The principal challenges are: a point resolution of a few microns, ultra-low mass (~0.2% X0 per layer for the vertex region and ~1% X0 per layer for the outer tracker), very low power dissipation (compatible with air-flow cooling in the inner vertex region) and pulsed power operation, complemented with ~10 ns time stamping capabilities. A highly granular all-silicon vertex and tracking detector system is under development, following an integrated approach addressing simultaneously the physics requirements and engineering constraints. For the vertex-detector region, hy- brid pixel detectors with small pitch (25 μm) and analogue readout are explored. For the outer tracking region,...

  1. Silicon pixel-detector R&D for CLIC

    CERN Document Server

    AUTHOR|(SzGeCERN)718101

    2016-01-01

    The physics aims at the future CLIC high-energy linear e+e- collider set very high precision requirements on the performance of the vertex and tracking detectors. Moreover, these detectors have to be well adapted to the experimental conditions, such as the time structure of the collisions and the presence of beam-induced backgrounds. The principal challenges are: a point resolution of a few μm, ultra-low mass (∼ 0.2% X${}_0$ per layer for the vertex region and ∼ 1 % X${}_0$ per layer for the outer tracker), very low power dissipation (compatible with air-flow cooling in the inner vertex region) and pulsed power operation, complemented with ∼ 10 ns time stamping capabilities. A highly granular all-silicon vertex and tracking detector system is under development, following an integrated approach addressing simultaneously the physics requirements and engineering constraints. For the vertex-detector region, hybrid pixel detectors with small pitch (25 μm) and analog readout are explored. For the outer trac...

  2. CLIC TWO-BEAM MODULE FOR THE CLIC CONCEPTUAL DESIGN AND RELATED EXPERIMENTAL PROGRAM*

    CERN Document Server

    Samoshkin, A; Solodko, A; Riddone, G

    2011-01-01

    The CLIC (Compact LInear Collider) study is a site independent study exploring technological developments to extend linear colliders into the Multi-TeV colliding beam energy range. The two-beam linear accelerator being studied at CERN involves the design and integration of many different technical systems, tightly bound and influencing each other. For the construction of two linacs it has been decided to proceed with a modular design, and repetitive two-beam modules of a few types were defined. The modules consist of micron-level precision components operating under ultra-high vacuum as required by the beam physics. For the CLIC Conceptual Design Report, the development and system integration is mainly focused on the most complex module type containing the highest number of components and technical systems. For proving the proper functioning of the needed technical systems and confirming their feasibility it has been decided to build four prototype modules and test them without beam. In addition, three module...

  3. CLIC Two-Beam Module for the CLIC Conceptual Design and related experimental program

    CERN Document Server

    Samoshkin, A; Solodko, A; Riddone, G

    2011-01-01

    The CLIC (Compact LInear Collider) study is a site independent study exploring technological developments to extend linear colliders into the Multi-TeV colliding beam energy range. The two-beam linear accelerator being studied at CERN involves the design and integration of many different technical systems, tightly bound and influencing each other. For the construction of two linacs it has been decided to proceed with a modular design, and repetitive two-beam modules of a few types were defined. The modules consist of micron-level precision components operating under ultra-high vacuum as required by the beam physics. For the CLIC Conceptual Design Report, the development and system integration is mainly focused on the most complex module type containing the highest number of components and technical systems. For proving the proper functioning of the needed technical systems and confirming their feasibility it has been decided to build four prototype modules and test them without beam. In addition, three module...

  4. Status of Ground Motion Mitigation Techniques for CLIC

    CERN Document Server

    Snuverink, J; Collette, C; Duarte Ramos, F; Gaddi, A; Gerwig, H; Janssens, S; Pfingstner, J; Schulte, D; Balik, G; Brunetti, L; Jeremie, A; Burrows, P; Caron, B; Resta-Lopez, J

    2011-01-01

    The Compact Linear Collider (CLIC) accelerator has strong stability requirements on the position of the beam. In particular, the beam position will be sensitive to ground motion. A number of mitigation techniques are proposed - quadrupole stabilisation and positioning, final doublet stabilisation as well as beam based orbit and interaction point (IP) feedback. Integrated studies of the impact of the ground motion on the CLIC Main Linac (ML) and Beam Delivery System (BDS) have been performed, which model the hardware and beam performance in detail. Based on the results future improvements of the mitigation techniques are suggested and simulated. It is shown that with the current design the tight luminosity budget for ground motion effects is fulfilled and accordingly, an essential feasibility issue of CLIC has been addressed.

  5. CLIC/ILC Researchers Explore New Avenues for Collaboration

    CERN Multimedia

    Katarina Anthony

    2010-01-01

    Researchers from CLIC and ILC met for their first common International Workshop on Linear Colliders, which was held in Geneva from 18 to 22 October. Although the talks were mostly scientific and technical, the political message behind them was a breakthrough, as the workshop showed the progress made in unifying the two communities.   The International Workshop on Linear Colliders (IWLC), which was organised by the European Committee for Future Accelerators, hosted by CERN, and held at CERN and the International Conference Centre in Geneva, attracted a large audience of about 500 experts. Although there have been other joint conferences between the CLIC and ILC communities before, they have all been focused on specific technical and/or managerial issues. The IWLC was part of an ongoing effort by CLIC and ILC to provide an environment in which researchers can exchange ideas, inform their peers about their most recent achievements and work together on common issues. Given the possible technical ov...

  6. X-Band Crab Cavities for the CLIC Beam Delivery System

    Energy Technology Data Exchange (ETDEWEB)

    Burt, G.; Ambattu, P.K.; Dexter, A.C.; Abram, T.; /Cockcroft Inst. Accel. Sci. Tech. /Lancaster U.; Dolgashev, V.; Tantawi, S.; /SLAC; Jones, R.M.; /Cockcroft Inst. Accel. Sci. Tech. /Manchester U.

    2011-11-22

    The CLIC machine incorporates a 20 mrad crossing angle at the IP to aid the extraction of spent beams. In order to recover the luminosity lost through the crossing angle a crab cavity is proposed to rotate the bunches prior to collision. The crab cavity is chosen to have the same frequency as the main linac (11.9942 GHz) as a compromise between size, phase stability requirements and beam loading. It is proposed to use a HE11 mode travelling wave structure as the CLIC crab cavity in order to minimise beam loading and mode separation. The position of the crab cavity close to the final focus enhances the effect of transverse wake-fields so effective wake-field damping is required. A damped detuned structure is proposed to suppress and de-cohere the wake-field hence reducing their effect. Design considerations for the CLIC crab cavity will be discussed as well as the proposed high power testing of these structures at SLAC. Design of a crab cavity for CLIC is underway at the Cockcroft Institute in collaboration with SLAC. This effort draws on a large degree of synergy with the ILC crab cavity developed at the Cockcroft Institute and other deflecting structure development at SLAC. A study of phase and amplitude variations in the cavity suggests that the tolerances are very tight and require a 'beyond state of the art' LLRF control system. A study of cavity geometry and its effect on the cavity fields has been performed using Microwave studio. This study has suggested that for our cavity an iris radius between 4-5 mm is optimum with an iris thickness of 2-3 mm based on group velocity and peak fields. A study of the cavity wakefields show that the single bunch wakes are unlikely to be a problem but the short bunch spacing may cause the multi-bunch wakefields to be an issue. This will require some of the modes to be damped strongly so that the wake is damped significantly before any following bunch arrives. Various methods of damping have been investigated and

  7. Grid Interface Challenges and Candidate Solutions for the Compact Linear Collider’s (CLIC) Klystron Modulators

    CERN Document Server

    Aguglia, D; Watson, A; Clare, J; Wheeler, P

    2014-01-01

    The Compact Linear Collider (CLIC) is a linear electron-positron accelerator under study at CERN, in view of exploring a new leptons collision energy region (0.5TeV to 5TeV). This complex requires ~1600 klystrons fed by highly efficient and controllable power electronics for a convenient power connection to the utility grid. This paper presents the challenges and evaluates several possible structures for the power system. Discussion are provided regarding the candidate topologies according to the converters’ ratings / number and considering reliability, modularity, and redundancy.

  8. Processing of three-dimensional structures of Nuclear Medicine in PET modality; Processamento de estruturas tridimensionais de medicina nuclear na modalidade PET

    Energy Technology Data Exchange (ETDEWEB)

    Pacheco, Edward Florez; Furuie, Sergio Shiguemi, E-mail: edward.florez@usp.br [Universidade de Sao Paulo (EP/USP), SP (Brazil). Dept. de Engenharia de Telecomunicacoes e Controle. Lab. de Engenharia Biomedica

    2013-03-15

    The nuclear medicine, as a specialty to obtain medical images is very important, and it has became one of the main procedures utilized in health care centers to analyze the metabolic behavior of the patient. This project was based on medical images obtained by the PET modality (Positron Emission Tomography). Thus, we developed a framework for processing Nuclear Medicine three-dimensional images of the PET modality, which is composed of consecutive steps that start with the generation of standard images (gold standard) by using simulated images of the Left Ventricular Heart, such as phantoms obtained from the NCAT-4D software. Then, Poisson quantum noise was introduced into the whole volume to simulate the characteristic noises in PET images. Subsequently, the pre-processing step was executed by using specific 3D filters, such as the median filter, the weighted Gaussian filter, and the Anscombe/Wiener filter. Then the segmentation process, which is based on the fuzzy connectedness theory, was implemented. For that purpose four different 3D approaches were implemented: Generic, LIFO, kTetaFOEMS, and dynamic weight algorithm. Finally, an assessment procedure was used as a measurement tool to quantify three parameters (true positive, false positive and maximum distance) that determined the level of efficiency and precision of our process. It was found that the pair filter - segmenter formed by the Anscombe/Wiener filter together with the Fuzzy segmenter based on dynamic weights provided the best results, with VP and FP rates of 98.49 {+-}0.27% and 2.19 {+-}0.19%, respectively, for the simulation of the left ventricular volume. Along with the set of choices made during the processing structure, the project was finished with the analysis of a small number of volumes that belonged to a real PET test, thus the quantification of the volumes was obtained. (author)

  9. Higgs Physics at the CLIC Electron-Positron Linear Collider

    CERN Document Server

    Roloff, Philipp Gerhard

    2016-01-01

    The Compact Linear Collider (CLIC) is an option for a future $e^+e^-$ collider operating at centre-of-mass energies up to 3 TeV, providing sensitivity to a wide range of new physics phenomena and precision physics measurements at the energy frontier. This paper presents the Higgs physics reach of CLIC operating in three energy stages, $\\sqrt{s} =$ 350 GeV, 1.4 TeV and 3 TeV. The initial stage of operation allows the study of Higgs boson production in Higgsstrahlung ($e^+e^-\\to ZH$) and $WW$-fusion ($e^+e^-\\to H\

  10. Vertex-Detector R&D for CLIC

    CERN Document Server

    Dannheim, D

    2014-01-01

    A detector concept based on hybrid planar pixel-detector technology is under development for the CLIC vertex detector. It comprises fast, low-power and small-pitch readout ASICs implemented in 65 nm CMOS technology (CLICpix) coupled to ultra-thin sensors via low-mass interconnects. The power dissipation of the readout chips is reduced by means of power pulsing, allowing for a cooling system based on forced gas flow. In this paper the CLIC vertex-detector requirements are reviewed and the current status of R&D on sensors, readout and detector integration is presented.

  11. Vertex-Detector R&D for CLIC

    CERN Document Server

    Dannheim, D

    2014-01-01

    A detector concept based on hybrid pixel-detector technology is under development for the CLIC vertex detector. It comprises fast, low-power and small-pitch readout ASICs implemented in 65 nm CMOS technology (CLICpix) coupled to ultra-thin sensors (planar or active HV-CMOS) via low-mass interconnects. The power dissipation of the readout chips is reduced by means of power pulsing, allowing for a cooling system based on forced air flow. In this contribution the CLIC vertex-detector requirements are reviewed and the current status of R&D on readout and sensors is presented.

  12. Development of a Cavity Beam Position Monitor for CLIC

    CERN Document Server

    Cullinan, F; Joshi, N; Lyapin, A; Calvo, E; Chritin, N; Guillot-Vignot, F; Lefevre, T; Søby, L; Lunin, A; Wendt, M; Yakovlev, V P; Smith, S

    2012-01-01

    The Compact Linear Collider (CLIC) project presents many challenges to its subsystems and the beam diagnostics in particular must perform beyond current limitations. The requirements for the CLIC main beam position monitors foresee a spacial resolution of 50 nm while delivering a 50 ns temporal resolution within the bunch train. We discuss the design of the microwave cavity pick-up and associated electronics, bench top tests with the first prototype cavity, as well as some of the machine-specific integration and operational issues.

  13. Structure/property development in aPET during large strain, solid phase polymer processing

    Science.gov (United States)

    Martin, Peter; Mohamed, Raja Roslan Raja

    2015-12-01

    Amorphous Polyethylene terephthalate (aPET) is increasingly of interest for the polymer packaging industry due to its blend of excellent mechanical properties and most importantly its ease of recyclability. Among the major commercial polymers it is almost unique in the degree of improvement in mechanical properties that can be obtained through process-induced strain. For many years these unique properties have been very successfully exploited in the injection stretch blow molding process, where it is deliberately stretched to very large strains using extremely high pressures. However, the material is now also being used in much lower pressure processes such as thermoforming where its properties are often not fully exploited. In this work the change in structure and properties of aPET with strain is systematically investigated using a high speed biaxial stretching machine. The aim was to demonstrate how the properties of the material could be controlled by large strain, high temperature biaxial stretching processes such as thermoforming and blow molding. The results show that property changes in the material are driven by orientation and the onset of rapid strain hardening at large strains. This in turn is shown to vary strongly with process-induced parameters such as the strain rate and the mode and magnitude of biaxial deformation.

  14. Pulse Power Modulator development for the CLIC Damping Ring Kickers

    CERN Document Server

    Holma, Janne

    2012-01-01

    The Compact Linear Collider (CLIC) study is exploring the scheme for an electron-positron collider with high luminosity (10-34 – 10-35 cm-2s-1) and a nominal centre-of-mass energy of 3 TeV: CLIC would complement LHC physics in the multi-TeV range. The CLIC design relies on Pre-Damping Rings (PDR) and Damping Rings (DR) to achieve the very low emittance, through synchrotron radiation, needed for the luminosity requirements of CLIC. To limit the beam emittance blow-up due to oscillations, the pulse power modulators for the DR kickers must provide extremely flat, high-voltage pulses: the 2 GHz specification called for a 160 ns duration flat-top of 12.5 kV, 250 A, with a combined ripple and droop of not more than ±0.02 %. In order to meet these demanding specifications, a combination of broadband impedance matching, optimized electrical circuit layout and advanced control techniques is required. A solid-state modulator, the inductive adder, is the most promising approach to meeting the demanding specifications...

  15. A Versatile Beam Loss Monitoring System for CLIC

    CERN Document Server

    Kastriotou, Maria; Farabolini, Wilfrid; Holzer, Eva Barbara; Nebot Del Busto, Eduardo; Tecker, Frank; Welsch, Carsten

    2016-01-01

    The design of a potential CLIC beam loss monitoring (BLM) system presents multiple challenges. To successfully cover the 48 km of beamline, ionisation chambers and optical fibre BLMs are under investigation. The former fulfils all CLIC requirements but would need more than 40000 monitors to protect the whole facility. For the latter, the capability of reconstructing the original loss position with a multi-bunch beam pulse and multiple loss locations still needs to be quantified. Two main sources of background for beam loss measurements are identified for CLIC. The two-beam accelerator scheme introduces so-called crosstalk, i.e. detection of losses originating in one beam line by the monitors protecting the other. Moreover, electrons emitted from the inner surface of RF cavities and boosted by the high RF gradients may produce signals in neighbouring BLMs, limiting their ability to detect real beam losses. This contribution presents the results of dedicated experiments performed in the CLIC Test Facility to qu...

  16. Occupancy in the CLIC_ILD Time Projection Chamber

    CERN Document Server

    KILLENBERG, M.

    2011-01-01

    We report on the occupancy in the CLIC ILD TPC caused by the beam induced background from gg !hadrons, e+e- pairs and beam halo muons. In addition the particle composition of the backgrounds and the origin of back-scattering particles have been studied.

  17. Grid Interface Design for the Compact Linear Collider (CLIC)

    CERN Document Server

    Jankovic, Maria; Clare, Jon; Wheeler, Pat; Aguglia, Davide

    2015-01-01

    This paper discusses the grid interface challenges for CERN’s proposed Compact Linear Colliders’ (CLIC) klystron modulators, including a 280 MW power system optimisation. The modular multilevel converter is evaluated as a candidate topology for a Medium Voltage grid interface along with a control method for reducing the impact of klystron modulators on the electrical network.

  18. Update on beam loss monitoring at CTF3 for CLIC

    CERN Document Server

    Devlin, L J; Effinger, E; Holzer, E B; del Busto, E N; Mallows, S; Branger, E

    2013-01-01

    The primary role of the beam loss monitoring (BLM) system for the compact linear collider (CLIC) study is to work within the machine protection system. Due to the size of the CLIC facility, a BLM that covers large distances along the beam line is highly desirable, in particular for the CLIC drive beam decelerators, which would alternatively require some ~40,000 localised monitors. Therefore, an optical fibre BLM system is currently under investigation which can cover large sections of beam line at a time. A multimode fibre has been installed along the Test Beam Line at the CLIC test facility (CTF3) where the detection principle is based on the production of Cherenkov photons within the fibre resulting from beam loss and their subsequent transport along the fibre where they are then detected at the fibre ends using silicon photomultipliers. Several additional monitors including ACEMs, PEP-II and diamond detectors have also been installed. In this contribution the first results from the BLMs are presented, comp...

  19. Silicon pixel-detector R&D for CLIC

    Science.gov (United States)

    Nürnberg, A.

    2016-11-01

    The physics aims at the future CLIC high-energy linear e+e- collider set very high precision requirements on the performance of the vertex and tracking detectors. Moreover, these detectors have to be well adapted to the experimental conditions, such as the time structure of the collisions and the presence of beam-induced backgrounds. The principal challenges are: a point resolution of a few μm, ultra-low mass (~ 0.2%X0 per layer for the vertex region and ~ 1%X0 per layer for the outer tracker), very low power dissipation (compatible with air-flow cooling in the inner vertex region) and pulsed power operation, complemented with ~ 10 ns time stamping capabilities. A highly granular all-silicon vertex and tracking detector system is under development, following an integrated approach addressing simultaneously the physics requirements and engineering constraints. For the vertex-detector region, hybrid pixel detectors with small pitch (25 μm) and analog readout are explored. For the outer tracking region, both hybrid concepts and fully integrated CMOS sensors are under consideration. The feasibility of ultra-thin sensor layers is validated with Timepix3 readout ASICs bump bonded to active edge planar sensors with 50 μm to 150 μm thickness. Prototypes of CLICpix readout ASICs implemented in 6525 nm CMOS technology with 25 μm pixel pitch have been produced. Hybridisation concepts have been developed for interconnecting these chips either through capacitive coupling to active HV-CMOS sensors or through bump-bonding to planar sensors. Recent R&D achievements include results from beam tests with all types of hybrid assemblies. Simulations based on Geant4 and TCAD are used to validate the experimental results and to assess and optimise the performance of various detector designs.

  20. Design and optimization of Compact Linear Collider main linac accelerating structure

    Science.gov (United States)

    Zha, Hao; Grudiev, Alexej

    2016-11-01

    The Compact Linear Collider (CLIC) main linac uses waveguide damped structure as its baseline design. The current baseline structure design written in the CLIC Conceptual Design Report is named "CLIC-G." Recent activities on the CLIC-G design including high power tests on structure prototypes and the study of machining cost assessment had raised the need of reoptimizing the structure design to minimize the machining cost and the pulse surface temperature rise. This work presents optimization of the structure geometry, high-order-mode (HOM) damping loads and the design of a HOM-free power splitter for the input coupler. Compared to the current baseline design CLIC-G, the new structure design reduced the pulse surface temperature rise, input power and manufacturing cost and achieves better suppression to the long range transverse wakefield. Cell disks and damping loads for the new structure design are also more compact than those of the CLIC-G design.

  1. CLIC Main Linac Beam-Loading Compensation by Drive Beam Phase Modulation

    CERN Document Server

    Corsini, R; Syratchev, I V

    1999-01-01

    The CLIC final focus momentum acceptance of ± 0.5 % limits the bunch-to-bunch energy variation in the main beam to less than ± 0.1 %, since the estimated single-bunch contribution is ± 0.4 %. On the other hand, a relatively high beam-loading of the main accelerating structures (about 16 %) is unavoidable in order to optimize the RF-to-beam efficiency. Therefore, a compensation method is needed to reduce the resulting bunch-to-bunch energy spread of the main beam. Up to now, it has been planned to obtain the RF pulse shape needed for compensation by means of a charge ramp in the drive beam pulse. On the other hand, the use of constant-current drive beam pulses would make the design and operation of the drive beam injector considerably simpler. In this paper we present a possible solution adapted to the CLIC two-beam scheme with constant-current pulses, based on phase modulation of the drive beam bunches.

  2. Common ground in ILC and CLIC detector concepts

    CERN Multimedia

    Daisy Yuhas

    2013-01-01

    The Compact Linear Collider and the International Linear Collider will accelerate particles and create collisions in different ways. Nonetheless, the detector concepts under development share many commonalities.   Timepix chips under scrutiny in the DESY test beam with the help of the beam telescope. CERN physicist Dominik Dannheim explains that the CLIC detector plans are adaptations of the ILC detector designs with a few select modifications. “When we started several years ago, we did not want to reinvent the wheel,” says Dannheim. “The approved ILC detector concepts served as an excellent starting point for our designs.” Essential differences Both CLIC and ILC scientists foresee general-purpose detectors that make measurements with exquisite precision. These colliders, however, have very different operating parameters, which will have important consequences for the various detector components. The ILC’s collision energy is set at 500 GeV ...

  3. Markerless rat head motion tracking using structured light for brain PET imaging of unrestrained awake small animals

    Science.gov (United States)

    Miranda, Alan; Staelens, Steven; Stroobants, Sigrid; Verhaeghe, Jeroen

    2017-03-01

    Preclinical positron emission tomography (PET) imaging in small animals is generally performed under anesthesia to immobilize the animal during scanning. More recently, for rat brain PET studies, methods to perform scans of unrestrained awake rats are being developed in order to avoid the unwanted effects of anesthesia on the brain response. Here, we investigate the use of a projected structure stereo camera to track the motion of the rat head during the PET scan. The motion information is then used to correct the PET data. The stereo camera calculates a 3D point cloud representation of the scene and the tracking is performed by point cloud matching using the iterative closest point algorithm. The main advantage of the proposed motion tracking is that no intervention, e.g. for marker attachment, is needed. A manually moved microDerenzo phantom experiment and 3 awake rat [18F]FDG experiments were performed to evaluate the proposed tracking method. The tracking accuracy was 0.33 mm rms. After motion correction image reconstruction, the microDerenzo phantom was recovered albeit with some loss of resolution. The reconstructed FWHM of the 2.5 and 3 mm rods increased with 0.94 and 0.51 mm respectively in comparison with the motion-free case. In the rat experiments, the average tracking success rate was 64.7%. The correlation of relative brain regional [18F]FDG uptake between the anesthesia and awake scan reconstructions was increased from on average 0.291 (not significant) before correction to 0.909 (p  <  0.0001) after motion correction. Markerless motion tracking using structured light can be successfully used for tracking of the rat head for motion correction in awake rat PET scans.

  4. Measurement of stau_1 pair production at CLIC

    CERN Document Server

    Muennich, A.

    2012-01-01

    We present a study performed for the CLIC Conceptual Design Report Volume 3 on the measurement of stau_1 pair production at sqrt(s) = 1.4 TeV. Only the hadronic decay of taus are considered. Results obtained using full detector simulation and including beam-induced backgrounds for the mass and for the production cross section of the stau_1 are discussed.

  5. Sensitivity Analysis for the CLIC Damping Ring Inductive Adder

    CERN Document Server

    Holma, Janne

    2012-01-01

    The CLIC study is exploring the scheme for an electron-positron collider with high luminosity and a nominal centre-of-mass energy of 3 TeV. The CLIC pre-damping rings and damping rings will produce, through synchrotron radiation, ultra-low emittance beam with high bunch charge, necessary for the luminosity performance of the collider. To limit the beam emittance blow-up due to oscillations, the pulse generators for the damping ring kickers must provide extremely flat, high-voltage pulses. The specifications for the extraction kickers of the CLIC damping rings are particularly demanding: the flattop of the output pulse must be 160 ns duration, 12.5 kV and 250 A, with a combined ripple and droop of not more than ±0.02 %. An inductive adder allows the use of different modulation techniques and is therefore a very promising approach to meeting the specifications. PSpice has been utilised to carry out a sensitivity analysis of the predicted output pulse to the value of both individual and groups of circuit compon...

  6. First phase of CLIC R&D complete

    CERN Multimedia

    Katarina Anthony

    2012-01-01

    Let’s turn back the clocks to 2002: the LHC is still under construction, the wrap-up of the LEP physics programme is still in recent memory and the future of electron-positron accelerators at CERN is ambiguous. It was then that CLIC set out to prove the feasibility of their novel accelerator design in the CTF3 test facility. Though once a tall order for the collaboration, the recently released CLIC Conceptual Design Report has proven many of the major design elements… bringing to an end the first phase of CLIC R&D and pointing toward detailed performance optimisation studies in the next phase.   Streak camera images of the final beam, illustrating the combination of beams in the Combiner Ring. Over a decade ago, the CTF3 team set up shop in the vacated LIL injector site, once home to the weathered machine that delivered electrons and positrons to LEP. Rebuilding and upgrading the machine piece by piece, the CTF3 team converted this mA linac into a high-current drive b...

  7. X-ray crystal structure of the passenger domain of plasmid encoded toxin(Pet), an autotransporter enterotoxin from enteroaggregative Escherichia coli (EAEC)

    Energy Technology Data Exchange (ETDEWEB)

    Domingo Meza-Aguilar, J. [Departamento de Salud Pública Facultad de Medicina UNAM, Ciudad Universitaria Coyoacán 04510, D.F. (Mexico); Laboratorio de Patogenicidad Bacteriana, Unidad de Hemato Oncología e Investigación, Hospital Infantil de México Federico Gómez 06720, D.F. (Mexico); Fromme, Petra [Department of Chemistry and Biochemistry, Arizona State University, Physical Sciences BLDG D-102, Tempe, AZ 85287 (United States); Torres-Larios, Alfredo [Instituto de Fisiología Celular UNAM, Ciudad Universitaria Coyoacán 04510, D.F. (Mexico); Mendoza-Hernández, Guillermo [Instituto de Química UNAM, Ciudad Universitaria Coyoacán 04510, D.F (Mexico); Hernandez-Chiñas, Ulises [Departamento de Salud Pública Facultad de Medicina UNAM, Ciudad Universitaria Coyoacán 04510, D.F. (Mexico); Laboratorio de Patogenicidad Bacteriana, Unidad de Hemato Oncología e Investigación, Hospital Infantil de México Federico Gómez 06720, D.F. (Mexico); Arreguin-Espinosa de los Monteros, Roberto A. [Instituto de Química UNAM, Ciudad Universitaria Coyoacán 04510, D.F (Mexico); and others

    2014-03-07

    Highlights: • X-ray crystal structure of the passenger domain of Plasmid encoded toxin at 2.3 Å. • Structural differences between Pet passenger domain and EspP protein are described. • High flexibility of the C-terminal beta helix is structurally assigned. - Abstract: Autotransporters (ATs) represent a superfamily of proteins produced by a variety of pathogenic bacteria, which include the pathogenic groups of Escherichia coli (E. coli) associated with gastrointestinal and urinary tract infections. We present the first X-ray structure of the passenger domain from the Plasmid-encoded toxin (Pet) a 100 kDa protein at 2.3 Å resolution which is a cause of acute diarrhea in both developing and industrialized countries. Pet is a cytoskeleton-altering toxin that induces loss of actin stress fibers. While Pet (pdb code: 4OM9) shows only a sequence identity of 50% compared to the closest related protein sequence, extracellular serine protease plasmid (EspP) the structural features of both proteins are conserved. A closer structural look reveals that Pet contains a β-pleaded sheet at the sequence region of residues 181–190, the corresponding structural domain in EspP consists of a coiled loop. Secondary, the Pet passenger domain features a more pronounced beta sheet between residues 135 and 143 compared to the structure of EspP.

  8. Transparent, flexible surface enhanced Raman scattering substrates based on Ag-coated structured PET (polyethylene terephthalate) for in-situ detection

    Science.gov (United States)

    Zuo, Zewen; Zhu, Kai; Gu, Chuan; Wen, Yibing; Cui, Guanglei; Qu, Jun

    2016-08-01

    Transparent, flexible surface-enhanced Raman scattering (SERS) substrates were fabricated by metalization of structured polyethylene terephthalate (PET) sheets. The resultant Ag-coated structured PET SERS substrates were revealed to be highly sensitive with good reproducibility and stability, an enhancement factor of 3 × 106 was acquired, which can be attributed mainly to the presence of plentiful multiple-type hot spots within the quasi-three-dimensional surface of the structured PET obtained by oxygen plasma etching. In addition, detections of model molecules on fruit skin were also carried out, demonstrating the great potential of the Ag-coated structured PET in in-situ detection of analyte on irregular objects. Importantly, the technique used for the preparation of such substrate is completely compatible with well-established silicon device technologies, and large-area fabrication with low cost can be readily realized.

  9. CLIC Detector Concepts as described in the CDR: Differences between the GEANT4 and Engineering Models

    CERN Document Server

    Elsener, K; Schlatter, D; Siegrist, N

    2011-01-01

    The CLIC_ILD and CLIC_SiD detector concepts as used for the CDR Vol. 2 in 2011 exist both in GEANT4 simulation models and in engineering layout drawings. At this early stage of a conceptual design, there are inevitably differences between these models, which are described in this note.

  10. Occupancy in the CLIC ILD Time Projection Chamber using Pixelised Readout

    CERN Document Server

    Killenberg, Martin

    2013-01-01

    The occupancy in the CLIC ILD TPC caused by the beam induced background from gamma gamma -> hadrons, e+e- pairs and beam halo muons is very high for conventional pad readout. We show that the occupancy for a pixelised TPC readout is moderate and might be a viable solution to operate a TPC at CLIC.

  11. Simulation of the pressure recovery time in a CLIC standard module

    CERN Document Server

    Costa-Pinto, P

    2008-01-01

    Vacuum pressure inside the CLIC accelerating structures (AS) is crucial for both beam and RF stability. Gas molecules released during RF breakdown must be evacuated from the cells of the AS before the arrival of the next train of particles. Due to its complex geometry, accurate analytical calculations are not viable. In this paper we introduce a calculation method based on the combination of analytical vacuum equations with Monte Carlo test particle simulations, implemented in a PSpice environment via the vacuum-electrical network analogy. Pressure recovery times are calculated for the main gas species released during a breakdown. The number and type of molecules used for the calculation is the result of measurements performed in the DC spark test system.

  12. Experience on Fabrication and Assembly of the First CLIC Two-Beam Module Prototype

    CERN Document Server

    Gudkov, D; Riddone, G; Rossi, F; Lebet, S

    2013-01-01

    The CLIC two-beam module prototypes are intended to prove the design of all technical systems under the different operation modes. Two validation programs are currently under way and they foresee the construction of four prototype modules for mechanical tests without beam and three prototype modules for tests with RF and beam. The program without beam will show the capability of the technical solutions proposed to fulfil the stringent requirements on radio-frequency, supporting, pre-alignment, stabilization, vacuum and cooling systems. The engineering design was performed with the use of CAD/CAE software. Dedicated mock-ups of RF structures, with all mechanical interfaces and chosen technical solutions, are used for the tests and therefore reliable results are expected. The components were fabricated by applying different technologies and methods for manufacturing and joining. The first full-size prototype module was assembled in 2012. This paper is focused on the production process including the comparison o...

  13. Recent results with HV-CMOS and planar sensors for the CLIC vertex detector

    CERN Document Server

    AUTHOR|(SzGeCERN)734627

    2016-01-01

    The physics aims for the future multi-TeV e+e- Compact Linear Collider (CLIC) impose high precision requirements on the vertex detector which has to match the experimental conditions, such as the time structure of the collisions and the presence of beam-induced backgrounds. The principal challenges are: a point resolution of 3μm, 10 ns time stamping capabilities, low mass (⇠0.2% X0 per layer), low power dissipation and pulsed power operation. Recent results of test beam measurements and GEANT4 simulations for assemblies with Timepix3 ASICs and thin active-edge sensors are presented. The 65 nm CLICpix readout ASIC with 25μm pitch was bump bonded to planar silicon sensors and also capacitively coupled through a thin layer of glue to active HV-CMOS sensors. Test beam results for these two hybridisation concepts are presented.

  14. Online Resources for High School Teachers--A CLIC Away

    Science.gov (United States)

    Holmes, Jon L.

    2000-04-01

    "I'm a high school teacher. I don't have time to sift through all of JCE to find what I need. I don't have enough time as it is!" If you need to find things in a hurry, go to JCE HS CLIC, the JCE High School Chemed Learning Information Center, http://JChemEd.chem.wisc.edu/HS/. You will find good solid, reliable information, and you will find it fast. CLIC is open 24 hours every day, all over the world. What You Will Find at JCE CLIC We know teachers are pressed for time. During the few minutes between classes or at the end of the day, information needs to be found very quickly. Perhaps you are looking for a demo that illustrates electrochemistry using Cu, Mg, orange juice, and a clock; or a student activity on chromatography that is ready to copy and hand out; or a video to illustrate the action of aqua regia on gold, because you can't use aqua regia and can't afford gold. You can find each of these quickly at CLIC. The Journal has always provided lots of articles designed with high school teachers in mind. What the new JCE HS CLIC does is collect the recent materials at one address on JCE Online, making it quicker and easier for you to find them. Information has been gathered from both print and online versions of the Journal, from JCE Software, and from JCE Internet. It is organized as shown at the bottom of the page. Getting Access to Information You have located something that interests you, perhaps a list of tested demonstrations that pertain to consumer chemistry. Now it is time to get it. JCE subscribers (individuals and libraries) can read, download, and print the full versions of the articles as well as all supplemental materials, including student handouts and instructor's notes. You will need the username and password that are on the mailing label that comes with your Journaleach month. JCE HS CLIC home page: http://JChemEd.chem.wisc.edu/HS/ Your Suggestions, Please Our plans for JCE HS CLIC do not end with what you find now. Other resources and features

  15. Analysis of the behaviour of the CLIC_SiD iron return yoke during a seismic event

    CERN Document Server

    Duarte Ramos, F.

    2012-01-01

    The iron return yoke of the CLIC SiD detector concept is composed of three barrel rings and two endcap discs which, during a seismic event, are subjected to horizontal and vertical accelerations that can result in both a mechanical failure of internal structural elements and high deformations which can lead to unwanted collisions with other internal or external detector elements, as well as the walls of the experimental cavern. This report presents the results from the analysis of the return yoke barrel rings and endcaps under a seismic event load case.

  16. Giardia & Pets

    Science.gov (United States)

    ... body of water Young pets, like puppies and kittens, have a higher risk of illness than adult ... If your pet has persistent diarrhea, seek veterinary care. Diarrhea has different causes and could result in ...

  17. Pet Health

    Science.gov (United States)

    Pets can add fun, companionship and a feeling of safety to your life. Before getting a pet, think carefully about which animal is best for ... is each family member looking for in a pet? Who will take care of it? Does anyone ...

  18. Design of a highly segmented Endcap at a CLIC detector

    CERN Document Server

    Gerwig, H; Siegrist, N

    2010-01-01

    This technical note describes a possible design for a highly segmented end-cap at a CLIC detector with a strong magnetic field up to 5 Tesla. Reinforcement is horizontal in order to allow an insertion of the muon chambers from the side. Construction issues, assembly questions as well as muon chamber access and support questions have been studied. A FEA analysis to optimize dead space for physics and checking the weakening effect of alignment channels through the end-cap have been performed.

  19. A prototype hybrid pixel detector ASIC for the CLIC experiment

    CERN Document Server

    Valerio, P; Arfaoui, S; Ballabriga, R; Benoit, M; Bonacini, S; Campbell, M; Dannheim, D; De Gaspari, M; Felici, D; Kulis, S; Llopart, X; Nascetti, A; Poikela, T; Wong, W S

    2014-01-01

    A prototype hybrid pixel detector ASIC specifically designed to the requirements of the vertex detector for CLIC is described and first electrical measurements are presented. The chip has been designed using a commercial 65 nm CMOS technology and comprises a matrix of 64x64 square pixels with 25 μm pitch. The main features include simultaneous 4-bit measure- ment of Time-over-Threshold (ToT) and Time-of-Arrival (ToA) with 10 ns accuracy, on-chip data compression and power pulsing capability.

  20. Estimation of potential radiation damage to electronics units in the CLIC tunnel

    CERN Document Server

    Patapenka, Andrei

    2014-01-01

    An electronic unit is required for each CLIC “Two Beam Module”. This study aims to estimate the potential damage due to the prompt radiation to the electronics units installed inside the CLIC Main Linac tunnel. Sets of Monte-Carlo simulations have been done to estimate damage to electronics installed at various locations inside the tunnel. Continuous and point beam losses have been considered for CLIC Main and Drive beams. Lead and iron in combination with a polyethylene layer were investigated as a possible shielding. The upper limits of the estimated quantities are presented for stand alone and shielded electronics.

  1. Transparent, flexible surface enhanced Raman scattering substrates based on Ag-coated structured PET (polyethylene terephthalate) for in-situ detection

    Energy Technology Data Exchange (ETDEWEB)

    Zuo, Zewen, E-mail: zuozewen@mail.ahnu.edu.cn; Zhu, Kai; Gu, Chuan; Wen, Yibing; Cui, Guanglei; Qu, Jun

    2016-08-30

    Highlights: • Transparent, flexible SERS substrates were prepared using techniques compatible with well-established silicon device technologies. • The SERS substrates exhibit high sensitivity and good reproducibility. • The high performance is related with the quasi-three-dimensional structure of the PET. • In-situ detection of analyte on irregular objects was achieved by this SERS substrate. - Abstract: Transparent, flexible surface-enhanced Raman scattering (SERS) substrates were fabricated by metalization of structured polyethylene terephthalate (PET) sheets. The resultant Ag-coated structured PET SERS substrates were revealed to be highly sensitive with good reproducibility and stability, an enhancement factor of 3 × 10{sup 6} was acquired, which can be attributed mainly to the presence of plentiful multiple-type hot spots within the quasi-three-dimensional surface of the structured PET obtained by oxygen plasma etching. In addition, detections of model molecules on fruit skin were also carried out, demonstrating the great potential of the Ag-coated structured PET in in-situ detection of analyte on irregular objects. Importantly, the technique used for the preparation of such substrate is completely compatible with well-established silicon device technologies, and large-area fabrication with low cost can be readily realized.

  2. Higgs Physics at the CLIC Electron-Positron Linear Collider

    CERN Document Server

    Abramowicz, H; Afanaciev, K; Tehrani, N Alipour; Balázs, C; Benhammou, Y; Benoit, M; Bilki, B; Blaising, J -J; Boland, M J; Boronat, M; Borysov, O; Božović-Jelisavčić, I; Buckland, M; Bugiel, S; Burrows, P N; Charles, T K; Daniluk, W; Dannheim, D; Dasgupta, R; Demarteau, M; Gutierrez, M A Díaz; Eigen, G; Elsener, K; Felzmann, U; Firlej, M; Firu, E; Fiutowski, T; Fuster, J; Gabriel, M; Gaede, F; García, I; Ghenescu, V; Goldstein, J; Green, S; Grefe, C; Hauschild, M; Hawkes, C; Hynds, D; Idzik, M; Kačarević, G; Kalinowski, J; Kananov, S; Klempt, W; Kopec, M; Krawczyk, M; Krupa, B; Kucharczyk, M; Kulis, S; Laštovička, T; Lesiak, T; Levy, A; Levy, I; Linssen, L; Lukić, S; Maier, A A; Makarenko, V; Marshall, J S; Mei, K; Milutinović-Dumbelović, G; Moroń, J; Moszczyński, A; Moya, D; Münker, R M; Münnich, A; Neagu, A T; Nikiforou, N; Nikolopoulos, K; Nürnberg, A; Pandurović, M; Pawlik, B; Codina, E Perez; Peric, I; Petric, M; Pitters, F; Poss, S G; Preda, T; Protopopescu, D; Rassool, R; Redford, S; Repond, J; Robson, A; Roloff, P; Ros, E; Rosenblat, O; Ruiz-Jimeno, A; Sailer, A; Schlatter, D; Schulte, D; Shumeiko, N; Sicking, E; Simon, F; Simoniello, R; Sopicki, P; Stapnes, S; Ström, R; Strube, J; Świentek, K P; Szalay, M; Tesař, M; Thomson, M A; Trenado, J; Uggerhøj, U I; van der Kolk, N; van der Kraaij, E; Pinto, M Vicente Barreto; Vila, I; Gonzalez, M Vogel; Vos, M; Vossebeld, J; Watson, M; Watson, N; Weber, M A; Weerts, H; Wells, J D; Weuste, L; Winter, A; Wojtoń, T; Xia, L; Xu, B; Żarnecki, A F; Zawiejski, L; Zgura, I -S

    2016-01-01

    The Compact Linear Collider (CLIC) is an option for a future e+e- collider operating at centre-of-mass energies up to 3 TeV, providing sensitivity to a wide range of new physics phenomena and precision physics measurements at the energy frontier. This paper presents the Higgs physics reach of CLIC operating in three energy stages, sqrt(s) = 350 GeV, 1.4 TeV and 3 TeV. The initial stage of operation allows the study of Higgs boson production in Higgsstrahlung (e+e- -> ZH) and WW-fusion (e+e- -> Hnunu), resulting in precise measurements of the production cross sections, the Higgs total decay width Gamma_H, and model-independent determinations of the Higgs couplings. Operation at sqrt(s) > 1 TeV provides high-statistics samples of Higgs bosons produced through WW-fusion, enabling tight constraints on the Higgs boson couplings. Studies of the rarer processes e+e- -> ttH and e+e- -> HHnunu would allow measurements of the top Yukawa coupling and the Higgs boson self-coupling. This paper presents detailed studies of...

  3. Validation of the CLIC alignment strategy on short range

    CERN Document Server

    Mainaud Durand, H; Griffet, S; Kemppinen, J; Rude, V; Sosin, M

    2012-01-01

    The pre-alignment of CLIC consists of aligning the components of linacs and beam delivery systems (BDS) in the most accurate possible way, so that a first pilot beam can circulate and allow the implementation of the beam based alignment. Taking into account the precision and accuracy needed: 10 µm rms over sliding windows of 200m, this pre-alignment must be active and it can be divided into two parts: the determination of a straight reference over 20 km, thanks to a metrological network and the determination of the component positions with respect to this reference, and their adjustment. The second part is the object of the paper, describing the steps of the proposed strategy: firstly the fiducialisation of the different components of CLIC; secondly, the alignment of these components on common supports and thirdly the active alignment of these supports using sensors and actuators. These steps have been validated on a test setup over a length of 4m, and the obtained results are analysed.

  4. Feasibility study of multipoint based laser alignment system for CLIC

    CERN Document Server

    Stern, G; Mainaud-Durand, H; Piedigrossi, D; Geiger, A

    2012-01-01

    CLIC (Compact LInear Collider) is a study for a future electron-positron collider that would allow physicists to explore a new energy region beyond the capabilities oftoday’s particle accelerators. Alignment is one of the major challenges within the CLIC study in order to achieve the high requirement of a multi-TeV center of mass colliding beam energy range (nominal 3 TeV). To reach this energy in a realistic and cost efficient scenario all accelerator components have to be aligned with an accuracy of 10 μm over a sliding window of 200 m. The demand for a straight line reference is so far based on stretched wires coupled with Wire Positioning Sensors (WPS). These solutions are currently further developed inorder to reduce the drawbacks which are mainly given by their costs and difficult implementation. However, it should be validated through inter-comparison with a solution ideally based on a different physical principle. Therefore, a new metrological approach is proposed using a laser beam as straight lin...

  5. Preliminary Design of an Inductive Adder for CLIC Damping Rings

    CERN Document Server

    Holma, J

    2011-01-01

    The Compact Linear Collider (CLIC) study is exploring the scheme for an electron-positron collider with high luminosity and a nominal centre-of-mass energy of 3 TeV. The CLIC damping rings will produce ultra-low emittance beam, with high bunch charge, necessary for the luminosity performance of the collider. To limit the beam emittance blow-up due to oscillations, the pulse power modulators for the damping rings kickers must provide extremely flat, high-voltage, pulses: specifications call for a 160 ns duration flattop of 12.5 kV, 250 A, with a combined ripple and droop of not more than ±0.02 %. A solid-state modulator, the inductive adder, is a very promising approach to meeting the demanding specifications; this topology allows the use of both digital and analogue modulation. To effectively use modulation techniques to achieve such low ripple and droop requires an in-depth knowledge of the behaviour of the solid-state switching components and their gate drivers, as well as a good understanding of the overa...

  6. R&D for the Vertexing at CLIC

    CERN Document Server

    Redford, S

    2015-01-01

    The Compact Linear Collider is a candidate to be the next high-energy particle physics collider. Using a novel acceleration technique, electrons and positrons would be brought into collision with a centre-of-mass energy of up to 3 TeV. Despite challenging levels of beam-induced background, this would provide a relatively clean environment in which to perform precision physics measurements. The vertex detector would be crucial in achieving this, and would need to provide accurate particle tracking information to facilitate secondary vertex reconstruction and jet flavour-tagging. With this goal in mind, current technological limits are being stretched to design a low occupancy, low mass and low-power dissipation vertex detector for CLIC. A concept comprising thin hybrid pixel detectors coupled to high- performance readout ASICs, power-pulsing and air-flow cooling is under development. In this paper, the CLIC vertex detector requirements are reviewed and the current status of R&D on sensors, readout, powerin...

  7. Brilliant positron sources for CLIC and other collider projects

    CERN Document Server

    Rinolfi, Louis; Dadoun, Olivier; Kamitani, Takuya; Strakhovenko, Vladimir; Variola, Alessandro

    2013-01-01

    The CLIC (Compact Linear Collider), as future linear collider, requires an intense positron source. A brief history is given up to the present baseline configuration which assumes unpolarized beams. A conventional scheme, with a single tungsten target as source of e-e+ pairs, has been studied several years ago. But, in order to reduce the beam energy deposition on the e+ target converter, a double-target system has been studied and proposed as baseline for CLIC. With this ‘‘hybrid target’’, the positron production scheme is based on the channeling process. A 5 GeV electron beam impinges on a thin crystal tungsten target aligned along its axis, enhancing the photon production by channeling radiation. A large number of photons are sent to a thick amorphous tungsten target, generating large number of e-e+ pairs, while the charged particles are bent away, reducing the deposited energy and the PEDD (Peak Energy Deposition Density). The targets parameters are optimized for the positron production. Polarize...

  8. Off-Axis Undulator Radiation for CLIC Drive Beam Diagnostics

    CERN Document Server

    Jeff, A; Welsch, CP

    2013-01-01

    The Compact LInear Collider (CLIC) will use a novel acceleration scheme in which energy extracted from a very intense beam of relatively low-energy electrons (the Drive Beam) is used to accelerate a lower intensity Main Beam to very high energy. The high intensity of the Drive Beam, with pulses of more than 1015 electrons, poses a challenge for conventional profile measurements such as wire scanners. Thus, new non-invasive profile measurements are being investigated. In this paper we propose the use of relatively inexpensive permanent-magnet undulators to generate off-axis visible Synchrotron Radiation from the CLIC Drive Beam. The field strength and period length of the undulator should be designed such that the on-axis undulator wavelength is in the ultra-violet. A smaller but still useable amount of visible light is then generated in a hollow cone. This light can be reflected out of the beam pipe by a ring-shaped mirror placed downstream and imaged on a camera. In this contribution, results of SRW and ZEMA...

  9. Crimping performance and morpho structure of PET/PTT conjugated yarn%PET/PTT复合纤维的卷曲性能与形态结构

    Institute of Scientific and Technical Information of China (English)

    郭静; 郑楠; 张欣; 李晓萌

    2011-01-01

    以POY-DT和FDY工艺获得的不同规格、本色和有色PET/PTT复合纤维为研究对象,考察了纤维规格、工艺路线和色母粒对PET/PTT复合纤维的卷缩性能的影响,表征了复合纤维的轴向形态结构与断面结构,研究了纤维力学性能.结果表明,PET/PTT复合纤维的卷曲性能随着线密度的增加而升高,在130 dtex附近达到峰值;本色复合纤维的卷曲收缩率、卷曲模量和弹性恢复率均高于有色复合纤维,而卷曲稳定度和紧缩伸长率则有色纤维较高,POY-DT工艺得到的复合纤维的卷曲收缩率、卷曲模量、紧缩伸长率、卷曲稳定度、断裂强度高于FDY工艺得到的纤维,但其弹性恢复率低于FDY纤维;经过湿热处理后的复合纤维的卷缩半径明显减小,卷缩性能得到提升;通过复合纤维断面SEM照片观察到,PET与PTT两相间界面黏合良好.%PET/PTT conjugated yarn with different specifications and different colors was obtained by POY-DT and FDY process route. The influence of specification, process route and master batch on crimp contraction property of PET/PTT conjugated yarn was investigated and the axial morphostructure, cross section and the mechanical property of the yarn were characterized. As a result, the crimp contraction of PET/PTT conjugated yarn is rised with the increasing linear density and reach its maximum at 130 dtex. The crimp contraction ratio, crimp module and elastic recovery of primary white PET/PTT conjugated yarn was higher than that of blue. The crimp stability and crimp elongation ratio of the blue PET/PTT conjugated yarn was higher than that of the primary white one. The crimp contraction ratio, crimp module, crimp elongation ratio, crimp stability and breaking strength of PET/PTT conjugated yarn obtained from POY-DY process route was higher than that obtained from FDY process route. But the elastic recovery of PET/PTT conjugated yarn obtained from POY-DY process route was lower than that

  10. Wakefield Monitor Experiments with X-Band Accelerating Structures

    CERN Document Server

    Lillestøl, Reidar; Corsini, Roberto; Döbert, Steffen; Farabolini, Wilfrid; Malina, Lukas; Pfingstner, Juergen; Wuensch, Walter

    2015-01-01

    The accelerating structures for CLIC must be aligned with a precision of a few um with respect to the beam trajectory in order to mitigate emittance growth due to transverse wake fields. We report on first results from wake field monitor tests in an X-band structure, with a probe beam at the CLIC Test Facility. The monitors are currently installed in the CLIC Two-Beam Module. In order to fully demonstrate the feasibility of using wakefield monitors for CLIC, the precision of the monitors must be verified using a probe beam while simultaneously filling the structure with high power rf used to drive the accelerating mode. We outline plans to perform such a demonstration in the CLIC Test Facility.

  11. Review of the Drive Beam Stabilization in the CLIC Test Facility CTF3

    CERN Document Server

    Dubrovskiy, A; Skowronski, P; Tecker, F; Persson, T

    2013-01-01

    CTF3 is a Test Facility focusing on beam-based studies of the key concepts of the Compact Linear Collider CLIC. Over the past several years many aspects of the CLIC two-beam acceleration scheme were studied in CTF3, including the crucial issue of drive beam stability. The main sources of drifts and instabilities have been identified and mitigated, helping to improve the machine performance and showing significant progress towards the experimental demonstration of the very stringent requirements on current, energy and phase stability needed in CLIC. In this paper, the more effective techniques and feed-backs are summarized. The latest measurements on beam stability are reported and their relevance to CLIC is discussed.

  12. Clinical application of PET

    Energy Technology Data Exchange (ETDEWEB)

    Lomena, Francisco [Hospital Clinico Villarroel, Barcelona (Spain). Nuclear Medicine]. E-mail: flomena@clinic.ub.es; Soler, Marina [CETIR Grup Medic. Esplkugues de Llobregat, Barcelona (Spain). PET Unit

    2005-10-15

    Positron emission tomography (PET) is an imaging modality that gives information on tissue metabolism and functionalism, different from other imaging techniques like computed tomography (CT) and magnetic resonance imaging (MRI), which provide anatomical or structural information. PET has reached its development in biomedical research because of its capacity to use analogous compounds of many endogenous substance as tracers, and to measure, in vivo and in a non-invasive way, their consumption by the different organs and tissues of the mammalian body. Fluorodeoxyglucose-F 18 (FDG) PET has been proven to be a tracer adequate for clinical use in oncology and in many neurological diseases, with an excellent cost-efficiency ratio. The current PET-CT scanners can come to be the best tools for exploring patients who suffer from cancer.(author)

  13. PACMAN – an Innovative Doctoral Programme for CLIC

    CERN Document Server

    CERN Bulletin

    2013-01-01

    The final network project funded under the European Commission’s Seventh Framework Programme (FP7), Marie Curie Actions, held its kick-off meeting at CERN on 20 November 2013.   PACMAN – a study on Particle Accelerator Components Metrology and Alignment to the Nanometre scale – is in the final stage of recruiting 10 PhD students to do research on beam instrumentation, metrology, micrometric alignment, magnetic measurements, nano-positioning and high-precision engineering. The students will acquire multi-disciplinary expertise in advanced engineering combined with a broad span of transferable skills. “PACMAN gives us the opportunity to attract students to CERN at a key moment in the CLIC study,” said Frédérick Bordry, Head of CERN’s Technology Department. “This is also an ideal opportunity to further develop CERN’s networks with industry and universities.” “The project is...

  14. Capacitively coupled hybrid pixel assemblies for the CLIC vertex detector

    CERN Document Server

    AUTHOR|(SzGeCERN)734627; Benoit, Mathieu; Dannheim, Dominik; Dette, Karola; Hynds, Daniel; Kulis, Szymon; Peric, Ivan; Petric, Marko; Redford, Sophie; Sicking, Eva; Valerio, Pierpaolo

    2016-01-01

    The vertex detector at the proposed CLIC multi-TeV linear e+e- collider must have minimal material content and high spatial resolution, combined with accurate time-stamping to cope with the expected high rate of beam-induced backgrounds. One of the options being considered is the use of active sensors implemented in a commercial high-voltage CMOS process, capacitively coupled to hybrid pixel ASICs. A prototype of such an assembly, using two custom designed chips (CCPDv3 as active sensor glued to a CLICpix readout chip), has been characterised both in the lab and in beam tests at the CERN SPS using 120 GeV/c positively charged hadrons. Results of these characterisation studies are presented both for single and dual amplification stages in the active sensor. Pixel cross-coupling results are also presented, showing the sensitivity to placement precision and planarity of the glue layer.

  15. Physics requirements for Scalar Muons searches at CLIC

    CERN Document Server

    Battaglia, M

    2010-01-01

    The determination of smuon and neutralino masses in smuon pair production is an important part of the program of spectroscopic studies of Supersymmetry at a high energy linear collider. In this note we report the first results of a study of e+e− → μ ̃R+μ ̃R− in a high-mass, cosmology-motivated Supersymmetric scenario at 3 TeV at CLIC. This process is a good example to study requirements on the beam energy spectrum and polarisation and the track momentum resolution in a simple final state. We discuss the expected accuracy on the mass measurements as a function of the momentum resolution, luminosity spectrum, beam polarisation and time stamping capability. Results obtained at generator level are validated by comparison to full simulation and reconstruction. Preliminary requirements for the detector performances and beam polarisation are presented.

  16. Analysis of SUSY Heavy Higgs events at CLIC

    CERN Document Server

    Quevillon, J

    2009-01-01

    This paper reports the results of a study of the supersymmetric neutral heavy Higgs boson production channel e+e− → H◦A◦ → bb ̄bb ̄ at √s = 3 TeV. Reconstruction of data simulated at generator level shows a significant degradation of SUSY Heavy Higgs signal caused by γγ to hadrons background at s = 3 TeV. The importance of analysis procedures such as event cuts and transversal momentum cuts during jet-clustering to reduce the impact of the hadron background is underlined. Reconstruction at both the generator level and at the level of a full detector simulation forces us to introduce cuts to improve the quality of the results. This note describes a preliminary study of SUSY Heavy Higgs at CLIC - a more detailed paper on an extended study is in preparation.

  17. Senior Pets

    Science.gov (United States)

    ... due to the normal aging process. Some behavior changes in older pets may be due to cognitive dysfunction, which is similar to senility in people. Common behavior changes in older pets that may be signs of cognitive dysfunction: easily disturbed by loud sounds unusually aggressive ...

  18. Effects of tensile strain on the peculiarities of PEO penetration into the nanoporous structure of PET deformed via the crazing mechanism.

    Science.gov (United States)

    Rukhlya, E G; Yarysheva, L M; Volynskii, A L; Bakeev, N F

    2016-04-14

    Solvent crazing involves the development of a highly dispersed fibrillar-porous structure with dimensions of pores and craze fibrils of about 2-20 nm, and crazing by itself can be treated as a universal method for the development of nanoscale porosity. The penetration and release of poly(ethylene oxide) macromolecules into and from the crazes during the development of the nanoporous structure of poly(ethylene terephthalate) have been studied. In particular, PET has been deformed in dilute or semidilute (unentangled as well as entangled) solutions of PEO (a Mw of 4 and 40 kDa) via the mechanism of solvent crazing. Hydrodynamic coil radii Rh, blob sizes ξ, and concentration ranges (crossover and entanglement concentrations) have been determined for the PEO solutions. The evolution of the craze structure (change in porosity W and pore diameters d) has been described as a function of the tensile strain of PET during its drawing in an adsorption-active medium and in the PEO solutions. PEO has been shown to penetrate into the nanoporous structure of the crazes under the conditions corresponding to Rh≤d and ξ PEO adsorption at the highly developed surface of PET, and the mechanism of PEO transport in the nanopores are equally important factors affecting the direction of the macromolecule mass transfer in the nanopores (penetration or release) and PEO content variation as a function of PET tensile strain.

  19. Innovations in PET/CT

    DEFF Research Database (Denmark)

    Levin Klausen, T; Høgild Keller, S; Vinter Olesen, O

    2012-01-01

    There has been a longstanding interest in positron emission tomography (PET) in combination with computed tomography (CT). Mostly because of the lack of structural information in PET which makes it difficult to assess the precise location of tissue with metabolic uptake, whereas CT can provide...

  20. Material and Structural Performance Evaluations of Hwangtoh Admixtures and Recycled PET Fiber-Added Eco-Friendly Concrete for CO2 Emission Reduction

    Directory of Open Access Journals (Sweden)

    Bon-Min Koo

    2014-08-01

    Full Text Available In order to reduce carbon dioxide (CO2 emissions and produce an eco-friendly construction material, a type of concrete that uses a minimal amount of cement, yet still retains equivalent properties to ordinary cement concrete, has been developed and studied all over the world. Hwangtoh, a type of red clay broadly deposited around the world, has traditionally been considered an eco-friendly construction material, with bonus advantages of having health and cost benefits. Presently, Hwangtoh is not commonly used as a modern construction material due to properties such as low strength and high rates of shrinkage cracking. Recent studies, however, have shown that Hwangtoh can be used as a mineral admixture to improve the strength of concrete. In addition, polyethylene terephthalate (PET fibers recycled from PET bottle waste can be used to control shrinkage cracks in Hwangtoh concrete. Therefore, in this study, performance verification is conducted on newly developed Hwangtoh concrete mixed with short recycled PET fibers. The results show that Hwangtoh concrete has compressive strength, elastic modulus, and pH properties that are similar to these features in ordinary cement concrete. The properties of carbonation depth and creep strain of Hwangtoh concrete, however, are larger and smaller, respectively, than in ordinary cement concrete. According to flexural tests, reinforced concrete (RC specimens cast with Hwangtoh admixtures (with and without PET fibers possess similar or better capacities than ordinary RC specimens. The addition of PET fibers significantly improves the structural ductility of RC specimens under normal environmental conditions. However, the implementations of the concrete in aggressive environment must be carefully considered, since a previous study result indicates degradation of its durability performance in aggressive environments, such as seawater [1]. The results of this study validate the possibility of using eco

  1. EM characterization of Damping materials for CLIC RF accelerating structures

    CERN Document Server

    De Michele, Giovanni

    2013-01-01

    Electromagnetic (EM) characterization of materials up to high frequencies is a major requirement for the correct modelling of many accelerator components: collimators, kickers, high order modes damping devices for accelerating cavities. Different methods and techniques have been used in the past and a unique setup for all kind of materials and frequencies range does not exist. In this note the details of our measurements setup and the different applied methods are described. This work will focus on the coaxial line setup that can be used in a wide range of frequencies. Reflection and transmission methods will be analyzed and discussed. Measurements of silicon carbide (SiC) CerasicB1, EkasicF and EkasicP will be presented

  2. Simultaneous evaluation of brain tumour metabolism, structure and blood volume using [{sup 18}F]-fluoroethyltyrosine (FET) PET/MRI: feasibility, agreement and initial experience

    Energy Technology Data Exchange (ETDEWEB)

    Henriksen, Otto M.; Hansen, Adam E.; Law, Ian [Copenhagen University Hospital Rigshospitalet Blegdamsvej, Department of Clinical Physiology Nuclear Medicine and PET, Copenhagen (Denmark); Larsen, Vibeke A. [Copenhagen University Hospital Rigshospitalet Blegdamsvej, Department of Radiology, Copenhagen (Denmark); Muhic, Aida; Poulsen, Hans S. [Copenhagen University Hospital Rigshospitalet Blegdamsvej, Department of Oncology, Copenhagen (Denmark); Larsson, Henrik B.W. [Copenhagen University Hospital Rigshospitalet Glostrup, Functional Imaging Unit, Department of Clinical Physiology Nuclear Medicine and PET, Glostrup (Denmark)

    2016-01-15

    Both [{sup 18}F]-fluoroethyltyrosine (FET) PET and blood volume (BV) MRI supplement routine T1-weighted contrast-enhanced MRI in gliomas, but whether the two modalities provide identical or complementary information is unresolved. The aims of the study were to investigate the feasibility of simultaneous structural MRI, BV MRI and FET PET of gliomas using an integrated PET/MRI scanner and to assess the spatial and quantitative agreement in tumour imaging between BV MRI and FET PET. A total of 32 glioma patients underwent a 20-min static simultaneous PET/MRI acquisition on a Siemens mMR system 20 min after injection of 200 MBq FET. The MRI protocol included standard structural MRI and dynamic susceptibility contrast (DSC) imaging for BV measurements. Maximal relative tumour FET uptake (TBR{sub max}) and BV (rBV{sub max}), and Dice coefficients were calculated to assess the quantitative and spatial congruence in the tumour volumes determined by FET PET, BV MRI and contrast-enhanced MRI. FET volume and TBR{sub max} were higher in BV-positive than in BV-negative scans, and both VOL{sub BV} and rBV{sub max} were higher in FET-positive than in FET-negative scans. TBR{sub max} and rBV{sub max} were positively correlated (R{sup 2} = 0.59, p < 0.001). FET and BV positivity were in agreement in only 26 of the 32 patients and in 42 of 63 lesions, and spatial congruence in the tumour volumes as assessed by the Dice coefficients was generally poor with median Dice coefficients exceeding 0.1 in less than half the patients positive on at least one modality for any pair of modalities. In 56 % of the patients susceptibility artefacts in DSC BV maps overlapped the tumour on MRI. The study demonstrated that although tumour volumes determined by BV MRI and FET PET were quantitatively correlated, their spatial congruence in a mixed population of treated glioma patients was generally poor, and the modalities did not provide the same information in this population of patients. Combined

  3. Relation between magnetic and structural anisotropy in the Ni23Se12(PEt3)13 cluster compound

    NARCIS (Netherlands)

    Narasimhan, L.R.; Palstra, T.T.M.; Tanzler, S.M.; Steigerwald, M.L.

    1995-01-01

    We have measured the magnetic properties of the cluster compound Ni23Se12(PEt3)13, where PEt3 is triethyl phosphine, by dc magnetization (1.5–300 K) and ac susceptibility (0.280–4 K). We observe a small, almost temperature-independent, magnetic moment of only ~2μB/cluster indicating the presence of

  4. Positron Emission Tomography (PET)

    Energy Technology Data Exchange (ETDEWEB)

    Welch, M.J.

    1990-01-01

    Positron emission tomography (PET) assesses biochemical processes in the living subject, producing images of function rather than form. Using PET, physicians are able to obtain not the anatomical information provided by other medical imaging techniques, but pictures of physiological activity. In metaphoric terms, traditional imaging methods supply a map of the body's roadways, its, anatomy; PET shows the traffic along those paths, its biochemistry. This document discusses the principles of PET, the radiopharmaceuticals in PET, PET research, clinical applications of PET, the cost of PET, training of individuals for PET, the role of the United States Department of Energy in PET, and the futures of PET. 22 figs.

  5. Positron Emission Tomography (PET)

    Science.gov (United States)

    Welch, M. J.

    1990-01-01

    Positron emission tomography (PET) assesses biochemical processes in the living subject, producing images of function rather than form. Using PET, physicians are able to obtain not the anatomical information provided by other medical imaging techniques, but pictures of physiological activity. In metaphoric terms, traditional imaging methods supply a map of the body's roadways, its, anatomy; PET shows the traffic along those paths, its biochemistry. This document discusses the principles of PET, the radiopharmaceuticals in PET, PET research, clinical applications of PET, the cost of PET, training of individuals for PET, the role of the United States Department of Energy in PET, and the futures of PET.

  6. 3D FEA Computation of the CLIC Machine Detector Interface Magnets

    CERN Document Server

    Bartalesi, A

    2012-01-01

    A critical aspect of the Compact Linear Collider (CLIC) design is represented by the Accelerator/Experiment interface (called Machine Detector Interface or MDI). In the 3 TeV CLIC layout, the final focus QD0 quadrupole will be located inside the end-cap of the detector itself. This complex MDI scenario required to be simulated with a full 3D-FE analysis. This study was critical to check and control the magnetic cross-talk between the detector solenoid and the final focus magnet and therefore to optimize the design of an “antisolenoids” system needed to shield the QD0 and the e-/e+ beams from the detector magnetic field. In this paper the development and evolution of the computational FE model is presented together with the results obtained and their implication on the CLIC MDI design.

  7. Mass and Cross Section Measurement of light-flavored Squarks at CLIC

    CERN Document Server

    Simon, Frank

    2012-01-01

    We present a study of the prospects for the measurement of TeV-scale light-flavored right-squark masses and the corresponding production cross section at a 3 TeV e+e- collider based on CLIC technology. The analysis, performed in the framework of the CLIC Conceptual Design Report, is based on full Geant4 simulations of the CLIC_ILD detector concept, including standard model physics background and machine related hadronic background from two-photon processes. The events are reconstructed using particle flow event reconstruction, and the mass is obtained from a template fit built from generator-level simulations with smearing to parametrize the detector response. For an integrated luminosity of 2/ab, a statistical precision of 5.9 GeV, corresponding to 0.52%, is obtained for unseparated first and second generation right squarks. For the combined cross section, a precision of 0.07 fb, corresponding to 5%, is obtained.

  8. PET and PET/CT in clinical cardiology

    Energy Technology Data Exchange (ETDEWEB)

    Won, Kyoung Sook [Keimyung University School of Medicine, Daegu (Korea, Republic of)

    2005-02-15

    Cardiac PET emerged as a powerful tool that allowed in vivo quantification of physiologic processes including myocardial perfusion and metabolism, as well as neuronal and receptor function for more than 25 years. Now PET imaging has been playing an important role in the clinical evaluation of patients with known or suspected ischemic heart disease. This important clinical role is expected to grow with the availability of PET/CT scanner that allow a true integration of structure and function. The objective of this review is to provide and update on the current and future role of PET in clinical cardiology with a special eye on the great opportunities now offered by PET/CT.

  9. Les mesures de métrologie pour le CLIC

    CERN Document Server

    Cherif, A

    2008-01-01

    Le projet CLIC est en tout point un défi technique majeur ; c?est le cas également pour la mesure dimensionnelle. Quels sont les équipements et les méthodes qui permettent de caractériser les pièces avec une incertitude de mesure aussi réduite que possible, vu les tolérances micrométriques imposées ? Afin de répondre à cette question, une veille technologique a été maintenue sur une longue période. Les acteurs relevants ont été contactés pour bénéficier d?une ouverture sur les dernières avancées dans le domaine. Différentes techniques ont été étudiées et comparées telles que la digitalisation, la tomographie X, la mesure tridimensionnelle. L'assemblage de haute précision des composants est aussi primordial. Sa mise en ?uvre sous un microscope optique ou à l'aide d'une machine tridimensionnelle est en cours d?étude. L'exposé traitera aussi de la mesure de rugosité, un domaine où nous disposons de moyens adaptés aux exigences spécifiques du projet.

  10. A New Technique For Information Processing of CLIC Technical Documentation

    CERN Document Server

    Tzermpinos, Konstantinos

    2013-01-01

    The scientific work presented in this paper could be described as a novel, systemic approach to the process of organization of CLIC documentation. The latter refers to the processing of various sets of archived data found on various CERN archiving services in a more friendly and organized way. From physics aspect, this is equal to having an initial system characterized by high entropy, which after some transformation of energy and matter will produce a final system of reduced entropy. However, this reduction in entropy can be considered valid for open systems only, which are sub-systems of grander isolated systems, to which the total entropy will always increase. Thus, using as basis elements from information theory, systems theory and thermodynamics, the unorganized form of data pending to be organized to a higher form, is modeled as an initial open sub-system with increased entropy, which, after the processing of information, will produce a final system with decreased entropy. This systemic approach to the ...

  11. Mustafa environment description and users' guide with applications to CLIC

    CERN Document Server

    Guignard, Gilbert

    1998-01-01

    In the main linacs of future linear colliders, the control of the emittances and the stability of a train of bunches are critical. It was therefore important for the Compact Linear Collider study (CLIC) to have a tool allowing numerical investigations of these questions. An interactive environment called MUSTAFA (MUltibunch Simulation and Tracking Algorithm for Future Accelerators) has been created and different tools have been developed over the time according to the needs. Progressively, these code and interactive facilities evolved into two main features, their portability on PCs independent from the main frame computers and their analysis capability using animated graphics. All the codes have been written under the MS-DOS operating system. The main application MBTR has been written in FORTRAN, the animated graphics facility MOVIE and the so-called MBUNCH utility program in QUICKBASIC (MS V4.5). The MBUNCH code was created in order to manage in a user friendly set-up the other two mentioned as well as the ...

  12. Top quark mass measurements at and above threshold at CLIC

    CERN Document Server

    Seidel, Katja; Tesar, Michal; Poss, Stephane

    2013-01-01

    We present a study of the expected precision of the top quark mass determination, measured at a linear $e^+e^-$ collider based on CLIC technology. GEANT4-based detector simulation and full event reconstruction including realistic physics and beam-induced background levels are used. Two different techniques to measure the top mass are studied: The direct reconstruction of the invariant mass of the top quark decay products and the measurement of the mass together with the strong coupling constant in a threshold scan, in both cases including first studies of expected systematic uncertainties. For the direct reconstruction, experimental uncertainties around 100 MeV are achieved, which are at present not matched by a theoretical understanding on a similar level. With a threshold scan, total uncertainties of around 100 MeV are achieved, including theoretical uncertainties in a well-defined top mass scheme. For the threshold scan, the precision at ILC is also studied to provide a comparison of the two linear collide...

  13. Detector optimization studies and light Higgs decay into muons at CLIC

    Energy Technology Data Exchange (ETDEWEB)

    Grefe, Christian

    2013-09-15

    The Compact Linear Collider (CLIC) is a concept for a future e{sup +}e{sup -} linear collider with a center-of-mass energy of up to 3 TeV. The design of a CLIC experiment is driven by the requirements related to the physics goals, as well as by the experimental conditions. For example, the short time between two bunch crossings of 0.5 ns and the backgrounds due to beamstrahlung have direct impact on the design of a CLIC experiment. The Silicon Detector (SiD) is one of the concepts currently being discussed as a possible detector for the International Linear Collider (ILC). In this thesis we develop a modified version of the SiD simulation model for CLIC, taking into account the specific experimental conditions. In addition, we developed a software tool to investigate the impact of beam-related backgrounds on the detector by overlaying events from different simulated event samples. Moreover, we present full simulation studies, determining the performance of the calorimeter and tracking systems. We show that the track reconstruction in the all-silicon tracker of SiD is robust in the presence of the backgrounds at CLIC. Furthermore, we investigate tungsten as a dense absorber material for the hadronic calorimeter, which allows for the construction of a compact hadronic calorimeter that fulfills the requirements on the energy resolution and shower containment without a significant increase of the coil radius. Finally, the measurement of the decays of light Higgs bosons into two muons is studied in full simulation. We find that with an integrated luminosity of 2 ab{sup -1}, corresponding to 4 years of data taking at CLIC, the respective Higgs branching ratio can be determined with a statistical uncertainty of approximately 15%.

  14. Design and characterization of a prototype stripline beam position monitor for the Clic Drive Beam*

    CERN Document Server

    Benot-Morell, A; Wendt, M; Nappa, J M; Tassan-Viol, J; Vilalte, S; Smith, S

    2012-01-01

    The prototype of a stripline Beam Position Monitor (BPM) with its associated readout electronics is under development at CERN, in collaboration with SLAC, LAPP and IFIC. The anticipated position resolution and accuracy are expected to be below 2μm and 20μm respectively for operation of the BPM in the CLIC drive beam (DB) linac. This paper describes the particular CLIC DB conditions with respect to the beam position monitoring, presents the measurement concept, and summarizes electromagnetic simulations and RF measurements performed on the prototype.

  15. Energy and Beam-Offset dependence of the Luminosity weighted depolarization for CLIC

    CERN Document Server

    Esberg, Jakob; Uggerhoj, Ulrik; Dalena, Barbara

    2011-01-01

    We report on simulations of e+e- depolarization due to beam-beam effects. These effects are studied for CLIC at 3 TeV, using GUINEA PIG++. We find a strong energy dependence of the luminosity weighted depolarization. In the luminosity peak at CLIC the total luminosity weighted depolarization remains below the one per-mil level. The effect of a vertical offset on the energy dependent depolarization is investigated. The depolarization in the luminosity peak remains below per-cent level even for 5sy offsets.

  16. Physics at the CLIC $e^{+}e^{-}$ Linear Collider - Input to the Snowmass process 2013

    CERN Document Server

    Abramowicz, Halina; Afanaciev, K.; Alexander, G.; Alipour Tehrani, N.; Alonso, O.; Andersen, K.K.; Arfaoui, S.; Balazs, C.; Barklow, T.; Battaglia, M.; Benoit, M.; Bilki, B.; Blaising, J.J.; Boland, M.; Boronat, M.; Bozovic Jelisavcic, I.; Burrows, P.; Chefdeville, M.; Contino, R.; Dannheim, D.; Demarteau, M.; Diaz Gutierrez, M.A.; Dieguez, A.; Duarte Campderros, J.; Eigen, G.; Elsener, K.; Feldman, D.; Felzmann, U.; Firlej, M.; Firu, E.; Fiutowski, T.; Francis, K.; Gaede, F.; Garcia Garcia, I.; Ghenescu, V.; Giudice, G.; Graf, N.; Grefe, C.; Grojean, C.; Gupta, R.S.; Hauschild, M.; Holmestad, H.; Idzik, M.; Joram, C.; Kananov, S.; Karyotakis, Y.; Killenberg, M.; Klempt, W.; Kraml, S.; Krupa, B.; Kulis, S.; Lastovicka, T.; LeBlanc, G.; Levy, A.; Levy, I.; Linssen, L.; Lucaci Timoce, A.; Lukic, S.; Makarenko, V.; Marshall, J.; Martin, V.; Mikkelsen, R.E.; Milutinovic-Dumbelovic, G.; Miyamoto, A.; Monig, K.; Moortgat-Pick, G.; Moron, J.; Munnich, A.; Neagu, A.; Pandurovic, M.; Pappadopulo, D.; Pawlik, B.; Porod, W.; Poss, S.; Preda, T.; Rassool, R.; Rattazzi, R.; Redford, S.; Reichold, A.; Repond, J.; Riemann, S.; Robson, A.; Roloff, P.; Ros, E.; Rosten, J.; Ruiz-Jimeno, A.; Rzehak, H.; Sailer, A.; Schlatter, D.; Schulte, D.; Sefkow, F.; Seidel, K.; Shumeiko, N.; Sicking, E.; Simon, F.; Smith, J.; Soldner, C.; Stapnes, S.; Strube, J.; Suehara, T.; Swientek, K.; Szalay, M.; Tanabe, T.; Tesar, M.; Thamm, A.; Thomson, M.; Trenado Garcia, J.; Uggerhoj, U.I.; van der Kraaij, E.; Vila, I.; Vilella, E.; Villarejo, M.A.; Vogel Gonzalez, M.A.; Vos, M.; Watson, N.; Weerts, H.; Wells, J.D.; Weuste, L.; Wistisen, T.N.; Wootton, K.; Xia, L.; Zawiejski, L.; Zgura, I.S.

    2013-01-01

    This paper summarizes the physics potential of the CLIC high-energy e+e- linear collider. It provides input to the Snowmass 2013 process for the energy-frontier working groups on The Higgs Boson (HE1), Precision Study of Electroweak Interactions (HE2), Fully Understanding the Top Quark (HE3), as well as The Path Beyond the Standard Model -- New Particles, Forces, and Dimensions (HE4). It is accompanied by a paper describing the CLIC accelerator study, submitted to the Frontier Capabilities group of the Snowmass process

  17. High frequency electromagnetic characterization of NEG properties for the CLIC damping rings

    CERN Document Server

    Koukovini-Platia, E; Zannini, C

    2014-01-01

    Coating materials will be used in the CLIC damping rings (DR) to suppress two-stream effects. In particular, NEG coating is necessary to suppress fast beam ion instabilities in the electron damping ring (EDR). The electromagnetic (EM) characterization of the material properties up to high frequencies is required for the impedance modeling of the CLIC DR components. The EM properties for frequencies of few GHz are determined with the waveguide method, based on a combination of experimental measurements of the complex transmission coefficient S21 and CST 3D EM simulations. The results obtained from a NEG-coated copper (Cu) waveguide are presented in this paper.

  18. Beam Dynamics for the Preliminary Phase of the New CLIC Test Facility (CTF3)

    CERN Document Server

    Corsini, R; Rinolfi, Louis; Risselada, Thys; Royer, P; Tecker, F A

    2001-01-01

    In the framework of the CLIC (Compact Linear Collider) RF power source studies, the scheme of electron pulse compression and bunch frequency mulitiplication, using injection by RF deflectors into an isochronous ring, will be tested, at low charge, during the preliminary phase of the new CLIC Test Facility (CTF3) at CERN. In this paper, we describe the beam dynamics studies made in order to assess the feasibility of the bunch combination experiment, as well as the related beam measurements performed on the LEP Pre-Injector complex (LPI) before its transformation into CTF3

  19. Structural MRI and Amyloid PET Imaging for Prediction of Conversion to Alzheimer's Disease in Patients with Mild Cognitive Impairment: A Meta-Analysis

    Science.gov (United States)

    Seo, Eun Hyun; Park, Woon Yeong

    2017-01-01

    Objective The aim of this study was to explore the prognostic values of biomarkers of neurodegeneration as measured by magnetic resonance imaging (MRI) and amyloid burden as measured by amyloid positron emission tomography (PET) in predicting conversion to Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI). Methods PubMed and EMBASE databases were searched for structural MRI or amyloid PET imaging studies published between January 2000 and July 2014 that reported conversion to AD in patients with MCI. Means and standard deviations or individual numbers of biomarkers with positive or negative status at baseline and corresponding numbers of patients who had progressed to AD at follow-up were retrieved from each study. The effect size of each biomarker was expressed as Hedges's g. Results Twenty-four MRI studies and 8 amyloid PET imaging studies were retrieved. 674 of the 1741 participants (39%) developed AD. The effect size for predicting conversion to AD was 0.770 [95% confidence interval (CI) 0.607–0.934] for across MRI and 1.316 (95% CI 0.920–1.412) for amyloid PET imaging (p<0.001). The effect size was 1.256 (95% CI 0.902–1.609) for entorhinal cortex volume from MRI. Conclusion Our study suggests that volumetric MRI measurement may be useful for the early detection of AD.

  20. PetIGA-MF: a multi-field high-performance toolbox for structure-preserving B-splines spaces

    KAUST Repository

    Sarmiento, A.F.

    2016-10-01

    We describe a high-performance solution framework for isogeometric discrete differential forms based on B-splines: PetIGA-MF. Built on top of PetIGA, an open-source library we have built and developed over the last decade, PetIGA-MF is a general multi-field discretization tool. To test the capabilities of our implementation, we solve different viscous flow problems such as Darcy, Stokes, Brinkman, and Navier-Stokes equations. Several convergence benchmarks based on manufactured solutions are presented assuring optimal convergence rates of the approximations, showing the accuracy and robustness of our solver.

  1. Pet Therapy.

    Science.gov (United States)

    Kavanagh, Kim

    1994-01-01

    This resource guide presents information on a variety of ways that animals can be used as a therapeutic modality with people having disabilities. Aspects addressed include: pet ownership and selection criteria; dogs (including service dogs, hearing/signal dogs, seeing leader dogs, and social/specialty dogs); horseriding for both therapy and fun;…

  2. HIGGS PHYSICS WITH A GAMMA GAMMA COLLIDER BASED ON CLIC 1*.

    Energy Technology Data Exchange (ETDEWEB)

    ASNER,D.; BURKHARDT,H.; DE ROECK,A.; ELLIS,J.; GRONBERG,J.; HEINEMEYER,S.; SCHMITT,M.; SCHULTE,D.; VELASCO,M.; ZIMMERMAN,F.

    2001-11-01

    We present the machine parameters and physics capabilities of the CLIC Higgs Experiment (CLICHE), a low-energy {gamma}{gamma} collider based on CLIC 1, the demonstration project for the higher-energy two-beam accelerator CLIC. CLICHE is conceived as a factory capable of producing around 20,000 light Higgs bosons per year. We discuss the requirements for the CLIC 1 beams and a laser backscattering system capable of producing a {gamma}{gamma} total (peak) luminosity of 2.0 (0.36) x 10{sup 34} cm{sup -2} s{sup -1} with E{sub CM}({gamma}{gamma}) 115 GeV. We show how CLICHE could be used to measure accurately the mass, {bar b}b, WW and {gamma}{gamma} decays of a light Higgs boson. We illustrate how these measurements may distinguish between the Standard Model Higgs boson and those in supersymmetric and more general two-Higgs-doublet models, complementing the measurements to be made with other accelerators. We also comment on other prospects in {gamma}{gamma} and e{sup -}{gamma} physics with CLICHE.

  3. Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity

    Science.gov (United States)

    Hernandez-Fernaud, Juan R.; Ruengeler, Elena; Casazza, Andrea; Neilson, Lisa J.; Pulleine, Ellie; Santi, Alice; Ismail, Shehab; Lilla, Sergio; Dhayade, Sandeep; MacPherson, Iain R.; McNeish, Iain; Ennis, Darren; Ali, Hala; Kugeratski, Fernanda G.; Al Khamici, Heba; van den Biggelaar, Maartje; van den Berghe, Peter V.E.; Cloix, Catherine; McDonald, Laura; Millan, David; Hoyle, Aoisha; Kuchnio, Anna; Carmeliet, Peter; Valenzuela, Stella M.; Blyth, Karen; Yin, Huabing; Mazzone, Massimiliano; Norman, Jim C.; Zanivan, Sara

    2017-01-01

    The secretome of cancer and stromal cells generates a microenvironment that contributes to tumour cell invasion and angiogenesis. Here we compare the secretome of human mammary normal and cancer-associated fibroblasts (CAFs). We discover that the chloride intracellular channel protein 3 (CLIC3) is an abundant component of the CAF secretome. Secreted CLIC3 promotes invasive behaviour of endothelial cells to drive angiogenesis and increases invasiveness of cancer cells both in vivo and in 3D cell culture models, and this requires active transglutaminase-2 (TGM2). CLIC3 acts as a glutathione-dependent oxidoreductase that reduces TGM2 and regulates TGM2 binding to its cofactors. Finally, CLIC3 is also secreted by cancer cells, is abundant in the stromal and tumour compartments of aggressive ovarian cancers and its levels correlate with poor clinical outcome. This work reveals a previously undescribed invasive mechanism whereby the secretion of a glutathione-dependent oxidoreductase drives angiogenesis and cancer progression by promoting TGM2-dependent invasion. PMID:28198360

  4. Benchmarking of the Placet and Dimad tracking codes using the CLIC Post-Collision line

    CERN Document Server

    Ahmed, I; Ferrari, A; Latina, A

    2009-01-01

    In this benchmarking study, two contemporary codes, DIMAD and PLACET, are compared. We consider the 20 mrad post-collision line of the Compact Linear Collider (CLIC) and perform tracking studies of heavily disrupted post-collision electron beams. We successfully find that the two codes provide an equivalent description of the beam transport from the interaction point to the final dump.

  5. Halo and tail simulations with applications to the CLIC drive beam

    CERN Document Server

    Fitterer, M; Adli, E; Burkhardt, H; Dalena, B; Rumolo, G; Schulte, D; Latina, A; Ahmed, I

    2010-01-01

    We report about generic halo and tail simulations and estimates. Previous studies weremainly focused on very high energies as relevant for the beam delivery systems of linear colliders. We have now studied, applied and extended these simulations to lower energies as relevant for the CLIC drive beam.

  6. Software and Parameters for Detailed TPC Studies in the CLIC CDR

    CERN Document Server

    Killenberg, M.

    2011-01-01

    For the TPC occupancy and time stamping studies in the CLIC CDR the MarlinTPC software package has been used in combination with Mokka for the full detector simulation. This document describes the working principle of the Marlin processors used for digitisation and reconstruction, and lists the parameters for reference.

  7. Clinical application of pet

    Directory of Open Access Journals (Sweden)

    Francisco Lomeña

    2005-10-01

    Full Text Available Positron emission tomography (PET is an imaging modality that gives information on tissue metabolism and functionalism, different from other imaging techniques like computed tomography (CT and magnetic resonance imaging (MRI, which provide anatomical or structural information. PET has reached its development in biomedical research because of its capacity to use analogous compounds of many endogenous substance as tracers, and to measure, in vivo and in a non-invasive way, their consumption by the different organs and tissues of the mammalian body. Fluordeoxyglucose-F18 (FDG PET has been proven to be a tracer adequate for clinical use in oncology and in many neurological diseases, with an excellent cost-efficiency ratio. The current PET-CT scanners can come to be the best tools for exploring patients who suffer from cancer.A tomografia por emissão de pósitrons (PET é uma técnica de diagnóstico por imagem que fornece informação sobre o metabolismo e funcionamento dos tecidos, diferente de outras técnicas de imagens como tomografia computadorizada (TC e ressonância magnética (RM, as quais fornecem informações estruturais ou anatômicas. O PET alcançou seu desenvolvimento em investigação biomédica devido à sua capacidade de usar traçadores análogos a muitas substâncias endógenas e de medir in vivo e de forma não invasiva seu consumo em diferentes órgãos e tecidos dos mamíferos 18Fluordesoxiglicose (FDG PET tem provado ser uma exploração de uso clínico com excelente relação custo benefício em oncologia e em muitas doenças neurológicas. Os atuais tomógrafos por PET-CT podem chegar a ser a melhor ferramenta de diagnóstico nos pacientes que sofrem de câncer.

  8. Engineering study, development and prototype fabrication of the supporting system for the CLIC Two-Beam Module

    CERN Document Server

    AUTHOR|(CDS)2068725; Karyotakis, Yannis; Dahoo, Pierre Richard; Alexopoulos, Theo; MEIS, Costantin; De Conto, Jean Marie; Jeremie, Andrea; Puzot, Patrique

    CERN, the European Organization for Nuclear Research, is based on the international collaboration in the field of high-energy particle physics research. The experiments carried out in its facilities are achieved through the existing particle accelerators. In addition, advanced accelerator research and development is one of the goals of CERN. For this reason, CLIC (the Compact LInear Collider) a new electron-positron linear accelerator is being studied at CERN. CLIC is built by the assembly of the Two-Beam Modules and takes advantage of an innovative acceleration principle, the Two-Beam acceleration. Each Module contains several technical systems that contribute to its successful operation. This thesis presents the development of the prototype supporting system for the CLIC Two-Beam Module. At first, the physics requirements are translated into technical specifications and the fundamental parts of the supporting system are defined. The CLIC operational conditions are identified and the corresponding boundaries...

  9. Regulation of the membrane insertion and conductance activity of the metamorphic chloride intracellular channel protein CLIC1 by cholesterol.

    Directory of Open Access Journals (Sweden)

    Stella M Valenzuela

    Full Text Available The Chloride Intracellular ion channel protein CLIC1 has the ability to spontaneously insert into lipid membranes from a soluble, globular state. The precise mechanism of how this occurs and what regulates this insertion is still largely unknown, although factors such as pH and redox environment are known contributors. In the current study, we demonstrate that the presence and concentration of cholesterol in the membrane regulates the spontaneous insertion of CLIC1 into the membrane as well as its ion channel activity. The study employed pressure versus area change measurements of Langmuir lipid monolayer films; and impedance spectroscopy measurements using tethered bilayer membranes to monitor membrane conductance during and following the addition of CLIC1 protein. The observed cholesterol dependent behaviour of CLIC1 is highly reminiscent of the cholesterol-dependent-cytolysin family of bacterial pore-forming proteins, suggesting common regulatory mechanisms for spontaneous protein insertion into the membrane bilayer.

  10. Regulation of the membrane insertion and conductance activity of the metamorphic chloride intracellular channel protein CLIC1 by cholesterol.

    Science.gov (United States)

    Valenzuela, Stella M; Alkhamici, Heba; Brown, Louise J; Almond, Oscar C; Goodchild, Sophia C; Carne, Sonia; Curmi, Paul M G; Holt, Stephen A; Cornell, Bruce A

    2013-01-01

    The Chloride Intracellular ion channel protein CLIC1 has the ability to spontaneously insert into lipid membranes from a soluble, globular state. The precise mechanism of how this occurs and what regulates this insertion is still largely unknown, although factors such as pH and redox environment are known contributors. In the current study, we demonstrate that the presence and concentration of cholesterol in the membrane regulates the spontaneous insertion of CLIC1 into the membrane as well as its ion channel activity. The study employed pressure versus area change measurements of Langmuir lipid monolayer films; and impedance spectroscopy measurements using tethered bilayer membranes to monitor membrane conductance during and following the addition of CLIC1 protein. The observed cholesterol dependent behaviour of CLIC1 is highly reminiscent of the cholesterol-dependent-cytolysin family of bacterial pore-forming proteins, suggesting common regulatory mechanisms for spontaneous protein insertion into the membrane bilayer.

  11. Processing and characterization of extruded PET and its r-PET and MWCNT nanocomposite thin films by spin coating

    Indian Academy of Sciences (India)

    Arvind R Singh; Vineeta D Deshpande

    2016-02-01

    The objective of the present study was basic understanding of the formation of thin film morphology by spin coating using reorganized polyethylene terephthalate (r-PET) and multiwalled carbon nanotubes (MWCNTs) as fillers in PET. A study of the correlation between physical properties of the PET films and its surface morphology was carried out using atomic force microscopy-based power spectral density (PSD) analysis. No significant work of surface analysis, using PSD of thin films of PET has been reported till date. Dilute solution of PET, PET with 3 wt% (r-PET) and PET with 3 wt% (2 wt% r-PET + 1 wt% MWCNT) filler were prepared using trifluoroacetic acid (TFA) as a solvent and thin films were fabricated on glass substrate by the optimized spin coating technique. Preparation of r-PET and r-PET+ MWCNT fillers was obtained by the precipitation method using TFA as a solvent and acetone as an antisolvent. The samples before spin coating were extruded and for comparison, a film of non-extruded PET was also prepared. Structural studies by Fourier transform infrared and X-ray diffraction show higher degree of crystallinity in r-PET and decrease in chain entanglements. Owing to the crystallizing behaviour of r-PET, it allows better dispersion of MWCNT in the polymer matrix as compared with PET. The samples with fillers of MWCNT show more compact and unique mesh-like globular structure, indicating application for electromagnetic shielding foams and fibres.

  12. Intracellular ion channel CLIC1: involvement in microglia-mediated β-amyloid peptide(1-42) neurotoxicity.

    Science.gov (United States)

    Skaper, Stephen D; Facci, Laura; Giusti, Pietro

    2013-09-01

    Microglia can exacerbate central nervous system disorders, including stroke and chronic progressive neurodegenerative diseases such as Alzheimer disease. Mounting evidence points to ion channels expressed by microglia as contributing to these neuropathologies. The Chloride Intracellular Channel (CLIC) family represents a class of chloride intracellular channel proteins, most of which are localized to intracellular membranes. CLICs are unusual in that they possess both soluble and integral membrane forms. Amyloid β-peptide (Aβ) accumulation in plaques is a hallmark of familial Alzheimer disease. The truncated Aβ25-35 species was shown previously to increase the expression of CLIC1 chloride conductance in cortical microglia and to provoke microglial neurotoxicity. However, the highly pathogenic and fibrillogenic full-length Aβ1-42 species was not examined, nor was the potential role of CLIC1 in mediating microglial activation and neurotoxicity by other stimuli (e.g. ligands for the Toll-like receptors). In the present study, we utilized a two chamber Transwell™ cell culture system to allow separate treatment of microglia and neurons while examining the effect of pharmacological blockade of CLIC1 in protecting cortical neurons from toxicity caused by Aβ1-42- and lipopolysaccaride-stimulated microglia. Presentation of Aβ1-42 to the upper, microglia-containing chamber resulted in a progressive loss of neurons over 3 days. Neuronal cell injury was prevented by the CLIC1 ion channel blockers IAA-94 [(R(+)-[(6,7-dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5yl)-oxy] acetic acid)] and niflumic acid (2-{[3-(trifluoromethyl)phenyl]amino}nicotinic acid) when presented to the upper chamber only. Incubation of microglia with lipopolysaccharide plus interferon-γ led to neuronal cell injury which, however, was insensitive to inhibition by the CLIC1 channel blockers, suggesting a degree of selectivity in agents leading to CLIC1 activation.

  13. Simultaneous evaluation of brain tumour metabolism, structure and blood volume using [18F]-fluoroethyltyrosine (FET) PET/MRI

    DEFF Research Database (Denmark)

    Henriksen, Otto M.; Larsen, Vibeke A; Muhic, Aida;

    2016-01-01

    PURPOSE: Both [(18)F]-fluoroethyltyrosine (FET) PET and blood volume (BV) MRI supplement routine T1-weighted contrast-enhanced MRI in gliomas, but whether the two modalities provide identical or complementary information is unresolved. The aims of the study were to investigate the feasibility...... congruence in the tumour volumes determined by FET PET, BV MRI and contrast-enhanced MRI. RESULTS: FET volume and TBRmax were higher in BV-positive than in BV-negative scans, and both VOLBV and rBVmax were higher in FET-positive than in FET-negative scans. TBRmax and rBVmax were positively correlated (R (2...

  14. Long span DNA paired-end-tag (DNA-PET sequencing strategy for the interrogation of genomic structural mutations and fusion-point-guided reconstruction of amplicons.

    Directory of Open Access Journals (Sweden)

    Fei Yao

    Full Text Available Structural variations (SVs contribute significantly to the variability of the human genome and extensive genomic rearrangements are a hallmark of cancer. While genomic DNA paired-end-tag (DNA-PET sequencing is an attractive approach to identify genomic SVs, the current application of PET sequencing with short insert size DNA can be insufficient for the comprehensive mapping of SVs in low complexity and repeat-rich genomic regions. We employed a recently developed procedure to generate PET sequencing data using large DNA inserts of 10-20 kb and compared their characteristics with short insert (1 kb libraries for their ability to identify SVs. Our results suggest that although short insert libraries bear an advantage in identifying small deletions, they do not provide significantly better breakpoint resolution. In contrast, large inserts are superior to short inserts in providing higher physical genome coverage for the same sequencing cost and achieve greater sensitivity, in practice, for the identification of several classes of SVs, such as copy number neutral and complex events. Furthermore, our results confirm that large insert libraries allow for the identification of SVs within repetitive sequences, which cannot be spanned by short inserts. This provides a key advantage in studying rearrangements in cancer, and we show how it can be used in a fusion-point-guided-concatenation algorithm to study focally amplified regions in cancer.

  15. American Pet Culture

    Institute of Scientific and Technical Information of China (English)

    海焰

    2007-01-01

    In America you can find dogs,cats, horses,monkeys, snakes and even pigs in almost every family.They are their pets.Americans love pets and look on them as a part of the family.Sometimes pet owners dress their pets in fashionable clothes.They even buy toys for their pets.Americans love their pets as their children, sometimes even better.

  16. Pet Problems at Home: Pet Problems in the Community.

    Science.gov (United States)

    Soltow, Willow

    1984-01-01

    Discusses problems of pets in the community, examining the community's role related to disruptive pets and pet overpopulation. Also discusses pet problems at home, offering advice on selecting a pet, meeting a pet's needs, and disciplining pets. Includes a list of books, films/filmstrips, teaching materials, and various instructional strategies.…

  17. PET-Computed Tomography in Veterinary Medicine.

    Science.gov (United States)

    Randall, Elissa K

    2016-05-01

    PET/CT is an advanced imaging modality that is becoming more commonly used in veterinary medicine. It is most commonly used to image patients with cancer, and the most frequently used radiopharmaceutical is F-18 FDG. F-18 FDG is a glucose analog that highlights areas of increased glucose metabolism on the PET images. CT images provide excellent anatomic depiction and aid in interpretation of the PET data. Many types of cancer are hypermetabolic on PET/CT scans, but normal structures and areas of inflammation are also hypermetabolic, so knowledge of normal imaging and cytologic or histopathologic evaluation of lesions is essential.

  18. Optimal Power System and Grid Interface Design Considerations for the CLICs Klystron Modulators

    CERN Document Server

    Marija, Jankovic; Jon, Clare; Pat, Wheeler; Davide, Aguglia

    2015-01-01

    The Compact Linear Collider (CLIC) is an electron-positron collider under study at CERN with the aim to explore the next generation of high precision/high energy particles physics. The CLIC’s drive beams will be accelerated by approximately 1300 klystrons, requiring highly efficient and controllable solid state capacitor discharge modulators. Capacitor charger specifications include the requirement to mask the pulsed effect of the load from the utility grid, ensure maximum power quality, control the derived DC voltage precisely (to maximize accuracy for the modulators being implemented), and achieve high efficiency and operability of the overall power system. This paper presents the work carried out on the power system interface for the CLIC facility. In particular it discusses the challenges on the utility interface and analysis of the grid interface converters with regards to required functionality, efficiency, and control methodologies.

  19. A prototype cavity beam position monitor for the CLIC Main Beam

    CERN Document Server

    Cullinany , F; Joshi, N; Lyapin, A; Bastard, D; Calvo, E; Chritin, N; Guillot-Vignot, F; Lefevre, T; Søby, L; Wendt, M; Lunin, A; Yakovlev, V P; Smith, S

    2012-01-01

    The Compact Linear Collider (CLIC) places unprecedented demands on its diagnostics systems. A large number of cavity beam position monitors (BPMs) throughout the main linac and beam delivery system (BDS) must routinely perform with 50 nm spatial resolution. Multiple position measurements within a single 156 ns bunch train are also required. A prototype low-Q cavity beam position monitor has been designed and built to be tested on the CLIC Test Facility (CTF3) probe beam. This paper presents the latest measurements of the prototype cavity BPM and the design and simulation of the radio frequency (RF) signal processing electronics with regards to the final performance. Installation of the BPM in the CTF3 probe beamline is also discussed.

  20. Correction of beam-beam effects in luminosity measurement in the forward region at CLIC

    CERN Document Server

    Lukic, Strahinja

    2013-01-01

    Procedures for correcting the beam-beam effects in luminosity measurement at CLIC at 3 TeV CM energy are described and tested using Monte Carlo simulations: -> Correction of the angular counting loss due to the combined Beamstrahlung and initial-state radiation (ISR) effects, based on the reconstructed velocity of the collision frame of the Bhabha scattering. -> Deconvolution of the luminosity spectrum distortion due to the ISR emission. -> Correction of the counting bias due to the finite calorimeter energy resolution. All procedures were tested by simulation. Bhabha events were generated using BHLUMI, and used in Guinea-PIG to simulate the outgoing momenta of Bhabha particles in the bunch collisions at CLIC. Residual uncertainties after correction are listed in a table in the conclusions. The beam-beam related systematic counting uncertainty in the luminosity peak can be reduced to the order of permille.

  1. Correction of beam-beam effects in luminosity measurement in the forward region at CLIC

    CERN Document Server

    Lukic, Strahinja

    2013-01-01

    Procedures for correcting the beam-beam effects in luminosity measurement at CLIC at 3 TeV CM energy are described and tested using Monte Carlo simulations: - Correction of the angular counting loss due to the combined Beamstrahlung and initial-state radiation (ISR) effects, based on the reconstructed velocity of the collision frame of the Bhabha scattering. - Deconvolution of the luminosity spectrum distortion due to the ISR emission. - Correction of the counting bias due to the finite calorimeter energy resolution. All procedures were tested by simulation. Bhabha events were generated using BHLUMI, and used in Guinea-PIG to simulate the outgoing momenta of Bhabha particles in the bunch collisions at CLIC. Residual uncertainties after correction are listed in a table in the conclusions. The beam-beam related systematic counting uncertainty in the luminosity peak can be reduced to the order of permille.

  2. CARE-JRA2* Activities on Photo-Injectors and CLIC Test Facility (CTF3)

    CERN Document Server

    Rinolfi, Louis

    2005-01-01

    In the frame of the CARE project, there is a Joint Research Activity (JRA2) called PHIN (PHoto-INjectors). The main objective of this JRA is to perform Research and Development on charge-production by interaction of a laser pulse with material within RF fields and improve or extend existing infrastructures. Another activity of PHIN is the coordination of the activities of various Institutes concerning photo-injectors. A brief review of the work of the eight European laboratories involved in PHIN is presented. One of these R&D topics is the construction of a photo-injector for the CLIC Test Facility (CTF3). In this context the status of CTF3 and its main goals - the demonstration of the feasibility of the key issues of the CLIC two-beam acceleration scheme - is also presented.

  3. Background and Energy Deposition Studies for the CLIC Post-Collision Line

    CERN Document Server

    Appleby, R B; Deacon, L C; Gschwendtner, E

    2011-01-01

    After the interaction point, the 1.5 TeV, 14MW CLIC electron/positron beams must be transported safely to the main beam dump. In designing the CLIC post-collision line detailed simulations must be carried out in order to ensure that losses are kept within reasonable limits. Results for back-scattered photon flux arriving at the detector are recalculated after updates and enhancements to the geometry description used in the study presented in [1]. Initial results of neutron fluxes are presented. Additionally, energy deposition calculations are carried out, showing that, when the full electromagnetic showers are included, in the current design the standard magnet coils would have a short lifetime due to radiation damage to conventional insulation material. Changing the magnet mask material from graphite to iron and lengthening the intermediate dump by 2m of iron are shown to substantially lessen the energy deposition in the magnet coils and thereby extend magnet lifetimes.

  4. Thermo-mechanical Analysis of the CLIC Post-Linac Energy Collimators

    CERN Document Server

    Resta-Lopez, J; Latina, A

    2012-01-01

    The post-linac energy collimation system of the Compact Linear Collider (CLIC) has been designed for passive protection of the Beam Delivery System (BDS) against miss-steered beams due to failure modes in the main linac. In this paper, a thermo-mechanical analysis of the CLIC energy collimators is presented. This study is based on simulations using the codes FLUKA and ANSYS when an entire bunch train hits the collimators. Different failure mode scenarios in the main linac are considered. The aim is to improve the collimator in order to make a reliable and robust design so that survives without damage the impact of a full bunch train in case of likely events generating energy errors.

  5. Stabilization of the Beam Intensity in the Linac at the CTF3 CLIC Test Facility

    CERN Document Server

    Dubrovskiy, A; Bathe, BN; Srivastava, S

    2013-01-01

    A new electron beam stabilization system has been introduced in CTF3 in order to open new possibilities for CLIC beam studies in ultra-stable conditions and to provide a sustainable tool to keep the beam intensity and energy at its reference values for long term operations. The stabilization system is based on a pulse-to-pulse feedback control of the electron gun to compensate intensity deviations measured at the end of the injector and at the beginning of the linac. Thereby it introduces negligible beam distortions at the end of the linac and it significantly reduces energy deviations. A self-calibration mechanism has been developed to automatically configure the feedback controller for the optimum performance. The residual intensity jitter of 0.045% of the stabilized beam was measured whereas the CLIC requirement is 0.075%.

  6. Clinical Computer Systems Survey (CLICS): learning about health information technology (HIT) in its context of use.

    Science.gov (United States)

    Lichtner, Valentina; Cornford, Tony; Klecun, Ela

    2013-01-01

    Successful health information technology (HIT) implementations need to be informed on the context of use and on users' attitudes. To this end, we developed the CLinical Computer Systems Survey (CLICS) instrument. CLICS reflects a socio-technical view of HIT adoption, and is designed to encompass all members of the clinical team. We used the survey in a large English hospital as part of its internal evaluation of the implementation of an electronic patient record system (EPR). The survey revealed extent and type of use of the EPR; how it related to and integrated with other existing systems; and people's views on its use, usability and emergent safety issues. Significantly, participants really appreciated 'being asked'. They also reminded us of the wider range of administrative roles engaged with EPR. This observation reveals pertinent questions as to our understanding of the boundaries between administrative tasks and clinical medicine - what we propose as the field of 'administrative medicine'.

  7. Design of the Injection and extraction system and related machine protection for the Clic Damping Rings

    CERN Document Server

    Apsimon, Robert; Barnes, Mike; Borburgh, Jan; Goddard, Brennan; Papaphilippou, Yannis; Uythoven, Jan

    2014-01-01

    Linear machines such as CLIC have relatively low rates of collision between bunches compared to their circular counterparts. In order to achieve the required luminosity, a very small spot size is envisaged at the interaction point, thus a low emittance beam is needed. Damping rings are essential for producing the low emittances needed for the CLIC main beam. It is crucial that the beams are injected and extracted from the damping rings in a stable and repeatable fashion to minimise emittance blow-up and beam jitter at the interaction point; both of these effects will deteriorate the luminosity at the interaction point. In this paper, the parameters and constraints of the injection and extraction systems are considered and the design of these systems is optimised within this parameter space. Related machine protection is considered in order to prevent damage from potential failure modes of the injection and extraction systems.

  8. Power pulsing scheme for analog and digital electronics of the vertex detectors at CLIC

    CERN Document Server

    Blanchot, Georges

    2015-01-01

    The precision requirements of the vertex detector at CLIC impose strong limitations on the mass of such a detector (< 0.2% of a radiation length, Xo, per layer). To achieve such a low material budget, ultra-thin hybrid pixel detectors are foreseen, while the mass for cooling and services will be reduced by implementing a power pulsing scheme that takes advantage of the low duty cycle of the accelerator. The principal aim is to achieve significant power reduction without compromising the power integrity supplied to the front-end electronics. This report summarises the study of a power pulsing scheme to power the vertex barrel electronics of the future CLIC experiment. Its main goal is to describe in more detail what has been already presented in TWEPP conferences and other presentations. The report can therefore serve as an operator manual for future use and development of the system

  9. Status of a study of stabilization and fine positioning of CLIC quadrupoles to the nanometre level

    CERN Document Server

    Artoos, K; Esposito, M; Fernandez Carmona, P; Guinchard, M; Hauviller, C; Janssens, S; Kuzmin, A; Leuxe, R; Moron Ballester, R

    2011-01-01

    Mechanical stability to the nanometre and below is required for the Compact Linear Collider (CLIC) quadrupoles to frequencies as low as 1 Hz. An active stabilization and positioning system based on very stiff piezo electric actuators and inertial reference masses is under study for the Main Beam Quadrupoles (MBQ). The stiff support was selected for robustness against direct forces and for the option of incrementally repositioning the magnet with nanometre resolution. The technical feasibility was demonstrated by a representative test mass being stabilized and repositioned to the required level in the vertical and lateral direction. Technical issues were identified and the development programme of the support, sensors, and controller was continued to increase the performance, integrate the system in the overall controller, adapt to the accelerator environment, and reduce costs. The improvements are implemented in models, test benches, and design of the first stabilized prototype CLIC magnet. The characterizati...

  10. Radiology for PET/CT reporting

    Energy Technology Data Exchange (ETDEWEB)

    Nanni, Cristina; Fanti, Stefano; Zanoni, Lucia [Univ. Hospital Sant Orsola-Malpighi, Bologna (Italy). Dept. of Nuclear Medicine

    2014-07-01

    Offers rapid access to slice by slice CT descriptions of anatomical structures from PET/CT studies. Presents images and descriptions of CT findings that may be detected while reviewing PET/CT scans. Includes principal MRI findings in diseases susceptible to PET/CT evaluation. Reading PET/CT scans is sometimes challenging. Not infrequently, abnormal findings on CT images are functionally silent and therefore difficult for nuclear medicine practitioners to interpret. Furthermore, in general only a low-dose CT scan is produced as part of the combined PET/CT study, and the resulting CT images may prove suboptimal for image interpretation. This atlas is designed to enable nuclear medicine practitioners who routinely read PET/CT scans to recognize the most common CT abnormalities. Slice-by-slice descriptions are provided of anatomical structures as visualized on CT scans obtained in PET/CT studies. The CT findings that may be detected while reviewing PET/CT scans of various body regions and conditions are then illustrated and fully described. The concluding section of the book is devoted to the principal MRI findings in diseases which cannot be evaluated using PETs/CTs.

  11. The Event Display for CLIC: DD4hep Compatibility and Improvements

    CERN Document Server

    Quast, Thorben

    2015-01-01

    This document is a short summary of my contributions to the Event Display for the CLICdp Software group in the context of CERN’s Summer Student Programme 2015. After a brief outline of CLIC and the relevant software package, the project is motivated. The individual achievements and their technical realizations are explained rather qualitatively, as details are well documented directly in the source code.

  12. Tracking Performance in High Multiplicity Environment for the CLIC ILD Detector

    CERN Document Server

    Killenberg, M

    2012-01-01

    We report on the tracking efficiency and the fraction of badly reconstructed tracks in the CLIC ILD detector for high multiplicity events (tt ̄@3 TeV) with and without the presence of γγ →hadrons background. They have been studied for the silicon tracking, the TPC tracking and the so called FullLDC tacking, which combines silicon and TPC measurements.

  13. Nonlinear Optimization of CLIC DRS New Design with Variable Bends and High Field Wigglers

    CERN Document Server

    Ghasem, H.; Alabau-Gonzalvo, J.; Papadopoulou, S.; Papaphilippou, Y.

    2016-01-01

    The new design of CLIC damping rings is based on longitudinal variable bends and high field superconducting wiggler magnets. It provides an ultra-low horizontal normalised emittance of 412 nm-rad at 2.86 GeV. In this paper, nonlinear beam dynamics of the new design of the damping ring (DR) with trapezium field profile bending magnets have been investigated in detail. Effects of the misalignment errors have been studied in the closed orbit and dynamic aperture.

  14. En route vers la nano stabilisation de CLIC faisceau principale et focalisation finale

    CERN Document Server

    Artoos, K; Guinchard, M; Hauviller, Claude; Lackner, F; CERN. Geneva. TS Department

    2008-01-01

    Pour atteindre la luminosité voulue de CLIC, la taille transversale du faisceau doit être de l?ordre du nanomètre. Ceci nécessite une stabilité vibratoire des quadripôles du faisceau principal de 1 nm et même 0.1 nm pour les doublets de la focalisation finale. La nano technologie et la nano stabilisation sont des activités qui évoluent rapidement dans l?industrie et centres de recherche pour des applications très variées comme l?électronique, l?optique, la chimie voire la médecine. Cette présentation décrit les avancées techniques nécessaires pour atteindre l?objectif de CLIC et les projets et collaborations R&D prévus pour démontrer la faisabilité de la nano stabilisation de CLIC en 2010.

  15. Evaluation of Components for the High Precision Inductive Adder for the CLIC Damping Rings

    CERN Document Server

    Holma, J

    2012-01-01

    The CLIC study is exploring the scheme for an electron-positron collider with high luminosity and a nominal centre-of-mass energy of 3 TeV. The CLIC damping rings will produce, through synchrotron radiation, ultra-low emittance beam with high bunch charge, necessary for the luminosity performance of the collider. To limit the beam emittance blow-up due to oscillations, the pulse generators for the damping ring kickers must provide extremely flat high-voltage pulses. The specifications for the extraction kickers of the CLIC damping rings are particularly demanding: the flattop of the output pulse must be 160 ns duration, 12.5 kV and 250 A, with a combined ripple and droop of not more than ±0.02 %. An inductive adder allows the use of different modulation techniques and is therefore a very promising approach to meeting the specifications. In addition to semiconductors working in their saturated region, semiconductors working in their linear region are needed for applying analogue modulation techniques. Simulat...

  16. Online optimisation of the CLIC Drive Beam bunch train recombination at CTF3

    CERN Document Server

    AUTHOR|(CDS)2082483; Tecker, Frank

    The Compact Linear Collider (CLIC) design is the leading alternative for a future multi-TeV "e^+e^−" linear collider. One of the key aspects of the design is the use of a Drive Beam as power source for the acceleration of the colliding beams. This work is focused on the optimisation of the set-up and the operations of the CLIC Drive Beam recombination at the CLIC Test Facility (CTF3) at CERN. The main effects that may affect the beam quality during the recombination are studied, with emphasis on orbit, transverse dynamics and beam energy effects. A custom methodology is used to analyse the problem, both from a theoretical and a numerical point of view. The aim is to provide first-order orbit and transverse optics constraints, which can be used as guidelines during the set-up of the beam recombination process. The developed techniques are applied at the CTF3, and the results are reported. The non-linear beam energy effects have been investigated by means of MAD-X simulations. The results show that these effe...

  17. Klystron Modulators for the 3 TeV CLIC Scheme An Overview

    CERN Document Server

    Pearce, P

    2001-01-01

    The CLIC (Compact Linear Collider) design is based on the Two-Beam technology being developed at CERN. The Drive Beam accelerator will have about 200 multi-beam klystron-modulator (MBK-M) RF power sources for each drive beam linac. These multi-beam klystrons (MBKs) should provide up to 50 MW peak power at 937 MHz, with a 100 ms pulse width and operating at 100 Hz repetition frequency. The CLIC drive beam injector will also use a number of these same MBK-Ms operating at slightly lower power levels. A 0.5 MW peak power, 468 MHz klystron with a bandwidth of around 150 MHz will be required for the sub-harmonic buncher in each drive beam injector chain as well. The Main Beams injector complex is required to deliver e+ and e- beams at 9 GeV via the transfer lines to the CLIC Main Beam accelerator. The present injector complex design uses a series of linacs to accelerate the electron and positron beams coming from RF guns working at 1.5 GHz up to an energy of 1.98 GeV before they are put into damping rings. Each of ...

  18. Mass and Cross Section Measurements of light-flavored Squarks at CLIC

    CERN Document Server

    WEUSTE, L.

    2011-01-01

    We present a study of the prospects for the measurement of TeV-scale light-flavored right-squark masses and and the production cross sections at a 3 TeV e+e- collider based on CLIC technology. The analysis, performed in the framework of the CLIC Conceptual Design Report, is based on full Geant4 simulations of the CLIC ILD detector concept, including standard model physics background and machine related hadronic background from two-photon processes. The events were reconstructed using particle flow event reconstruction, and the mass and cross sections were obtained from a template fit built from generator-level simulations with smearing to parametrize the detector response. For an integrated luminosity of 2 ab^-1, a statistical precision of 5.9 GeV, corresponding to 0.52%, was obtained for unseparated first and second generation right squarks. For the combined cross section, a precision of 0.07 fb, corresponding to 5%, was obtained.

  19. Quantitative Techniques in PET-CT Imaging

    NARCIS (Netherlands)

    Basu, Sandip; Zaidi, Habib; Holm, Soren; Alavi, Abass

    2011-01-01

    The appearance of hybrid PET/CT scanners has made quantitative whole body scanning of radioactive tracers feasible. This paper deals with the novel concepts for assessing global organ function and disease activity based on combined functional (PET) and structural (CT or MR) imaging techniques, their

  20. Deformation field correction for spatial normalization of PET images

    Science.gov (United States)

    Bilgel, Murat; Carass, Aaron; Resnick, Susan M.; Wong, Dean F.; Prince, Jerry L.

    2015-01-01

    Spatial normalization of positron emission tomography (PET) images is essential for population studies, yet the current state of the art in PET-to-PET registration is limited to the application of conventional deformable registration methods that were developed for structural images. A method is presented for the spatial normalization of PET images that improves their anatomical alignment over the state of the art. The approach works by correcting the deformable registration result using a model that is learned from training data having both PET and structural images. In particular, viewing the structural registration of training data as ground truth, correction factors are learned by using a generalized ridge regression at each voxel given the PET intensities and voxel locations in a population-based PET template. The trained model can then be used to obtain more accurate registration of PET images to the PET template without the use of a structural image. A cross validation evaluation on 79 subjects shows that the proposed method yields more accurate alignment of the PET images compared to deformable PET-to-PET registration as revealed by 1) a visual examination of the deformed images, 2) a smaller error in the deformation fields, and 3) a greater overlap of the deformed anatomical labels with ground truth segmentations. PMID:26142272

  1. Measurement of the H$\\rightarrow$WW$^*$ Branching Ratio at 1.4TeV using the semileptonic final state at CLIC

    CERN Document Server

    AUTHOR|(SzGeCERN)762723; Watson, Nigel

    2016-01-01

    This note summarises a study to evaluate the potential to measure the H$\\rightarrow$WW$^*$ branching fraction at CLIC, 1.4TeV centre-of-mass energy, with the CLIC_ILD detector, using the WW$\\rightarrow$qql$\

  2. Evaluation of software tools for automated identification of neuroanatomical structures in quantitative β-amyloid PET imaging to diagnose Alzheimer's disease

    Energy Technology Data Exchange (ETDEWEB)

    Tuszynski, Tobias; Luthardt, Julia; Butzke, Daniel; Tiepolt, Solveig; Seese, Anita; Barthel, Henryk [Leipzig University Medical Centre, Department of Nuclear Medicine, Leipzig (Germany); Rullmann, Michael; Hesse, Swen; Sabri, Osama [Leipzig University Medical Centre, Department of Nuclear Medicine, Leipzig (Germany); Leipzig University Medical Centre, Integrated Treatment and Research Centre (IFB) Adiposity Diseases, Leipzig (Germany); Gertz, Hermann-Josef [Leipzig University Medical Centre, Department of Psychiatry, Leipzig (Germany); Lobsien, Donald [Leipzig University Medical Centre, Department of Neuroradiology, Leipzig (Germany)

    2016-06-15

    For regional quantification of nuclear brain imaging data, defining volumes of interest (VOIs) by hand is still the gold standard. As this procedure is time-consuming and operator-dependent, a variety of software tools for automated identification of neuroanatomical structures were developed. As the quality and performance of those tools are poorly investigated so far in analyzing amyloid PET data, we compared in this project four algorithms for automated VOI definition (HERMES Brass, two PMOD approaches, and FreeSurfer) against the conventional method. We systematically analyzed florbetaben brain PET and MRI data of ten patients with probable Alzheimer's dementia (AD) and ten age-matched healthy controls (HCs) collected in a previous clinical study. VOIs were manually defined on the data as well as through the four automated workflows. Standardized uptake value ratios (SUVRs) with the cerebellar cortex as a reference region were obtained for each VOI. SUVR comparisons between ADs and HCs were carried out using Mann-Whitney-U tests, and effect sizes (Cohen's d) were calculated. SUVRs of automatically generated VOIs were correlated with SUVRs of conventionally derived VOIs (Pearson's tests). The composite neocortex SUVRs obtained by manually defined VOIs were significantly higher for ADs vs. HCs (p=0.010, d=1.53). This was also the case for the four tested automated approaches which achieved effect sizes of d=1.38 to d=1.62. SUVRs of automatically generated VOIs correlated significantly with those of the hand-drawn VOIs in a number of brain regions, with regional differences in the degree of these correlations. Best overall correlation was observed in the lateral temporal VOI for all tested software tools (r=0.82 to r=0.95, p<0.001). Automated VOI definition by the software tools tested has a great potential to substitute for the current standard procedure to manually define VOIs in β-amyloid PET data analysis. (orig.)

  3. Pets and the immunocompromised person

    Science.gov (United States)

    AIDS patients and pets; Bone marrow transplant patients and pets; Chemotherapy patients and pets ... systems may be advised to give up their pets to avoid getting diseases from the animals. People ...

  4. Trends in PET imaging

    Energy Technology Data Exchange (ETDEWEB)

    Moses, William W.

    2000-11-01

    Positron Emission Tomography (PET) imaging is a well established method for obtaining information on the status of certain organs within the human body or in animals. This paper presents an overview of recent trends PET instrumentation. Significant effort is being expended to develop new PET detector modules, especially those capable of measuring depth of interaction. This is aided by recent advances in scintillator and pixellated photodetector technology. The other significant area of effort is development of special purpose PET cameras (such as for imaging breast cancer or small animals) or cameras that have the ability to image in more than one modality (such as PET / SPECT or PET / X-Ray CT).

  5. The spatial distribution of pet dogs and pet cats on the island of Ireland

    Directory of Open Access Journals (Sweden)

    More Simon J

    2011-06-01

    Full Text Available Abstract Background There is considerable international research regarding the link between human demographics and pet ownership. In several international studies, pet ownership was associated with household demographics including: the presence of children in the household, urban/rural location, level of education and age/family structure. What is lacking across all these studies, however, is an understanding of how these pets are spatially distributed throughout the regions under study. This paper describes the spatial distribution of pet dog and pet cat owning households on the island of Ireland. Results In 2006, there were an estimated 640,620 pet dog owning households and 215,542 pet cat owning households in Ireland. These estimates are derived from logistic regression modelling, based on household composition to determine pet dog ownership and the type of house to determine pet cat ownership. Results are presented using chloropleth maps. There is a higher density of pet dog owning households in the east of Ireland and in the cities than the west of Ireland and rural areas. However, in urban districts there are a lower proportion of households owning pet dogs than in rural districts. There are more households with cats in the urban areas, but the proportion of households with cats is greater in rural areas. Conclusions The difference in spatial distribution of dog ownership is a reflection of a generally higher density of households in the east of Ireland and in major cities. The higher proportion of ownership in the west is understandable given the higher proportion of farmers and rural dwellings in this area. Spatial representation allows us to visualise the impact of human household distribution on the density of both pet dogs and pet cats on the island of Ireland. This information can be used when analysing risk of disease spread, for market research and for instigating veterinary care.

  6. Parálisis cerebral y sistemas de seguimiento de la mirada: ¿clic por parpadeo o permanencia?

    OpenAIRE

    Clemotte, Alejandro; Velasco, Miguel; Raya, Rafael; Ceres, Ramón; Córdoba Herralde, Ricardo de

    2015-01-01

    Los comandos básicos para el control de ordenadores a través de interfaces gráficas son comandos de alcance a un objeto en pantalla y su selección. El presente documento describe un estudio comparativo a nivel funcional de dos estrategias de selección alternativas, especialmente diseñada para personas con parálisis cerebral: clic por permanencia y clic por parpadeo, mientras que la tarea de alcance se realiza a través de movimientos oculares.

  7. Leptospirosis and Pets

    Science.gov (United States)

    ... Bacterial Special Pathogens Branch (BSPB) BSPB Laboratory Submissions Pets Recommend on Facebook Tweet Share Compartir Leptospirosis is ... that can affect human and animals, including your pets. All animals can potentially become infected with Leptospirosis. ...

  8. Heart PET scan

    Science.gov (United States)

    ... nuclear medicine scan; Heart positron emission tomography; Myocardial PET scan ... A PET scan requires a small amount of radioactive material (tracer). This tracer is given through a vein (IV), ...

  9. Study of readout architectures for triggerless high event rate detectors at CLIC

    CERN Document Server

    Kulis, S

    2011-01-01

    In this work possible readout architectures for future detectors at CLIC are discussed. These detectors will need a triggerless readout electronics with amplitude and time reconstruction and they may operate with very high event rates (≥ 1 hits / channel / bunch train of 156 ns). The main subject of this study, both theoretical and experimental, is a readout based on the deconvolution principle. The basic principle, the performance, the advantages and limitations of this technique are discussed. In the case of extremely high event rates (> 4 hits / channel / bunch train) a readout based on a gated integrator and correlated double sampling is proposed.

  10. The CLIC study of a multi-TeV linear collider

    CERN Document Server

    Delahaye, J P

    2011-01-01

    The article reviews the status of the Compact Linear Collider (CLIC) study towards feasibility demonstration of a novel and challenging technology which has been specially developed to extend Linear Colliders energy reach into the multi-TeV range in order to be complementary to LHC (Large Hadron Collider). A Conceptual Design Report is being published summarizing the performance of a High Energy facility based on such a technology as well as the results of the R&D performed to address its feasibility.

  11. Background at the Interaction Point from the CLIC Post-Collision Line

    CERN Document Server

    Salt, M D; Apyan, A; Elsener, K; Gschwendtner, E; Ferrari, A

    2010-01-01

    The 1.5 TeV electron/positron CLIC beams, with a total power of 14 MW per beam, are disrupted at the interaction point (IP) due to the very strong beam-beam effect. The resulting spent beam products are transported to suitable dumps by the post-collision beam line, which generates beam losses and causes the production of secondary cascades towards the interaction region. In this paper the electromagnetic backgrounds at the IP are presented, which were calculated using biasing Monte Carlo techniques. Also, a first estimate is made of neutron backshine from the main beam dump.

  12. THE ANTI-SOLENOID COMPENSATION OF THE CLIC DETECTOR SOLENOID USING IRSYN

    CERN Document Server

    Appleby, R B

    2011-01-01

    The detector solenoid of CLIC causes a range of aberrations on the beam at the interaction point, particularly due to its overlap with the final focus magnets. These effects are corrected using antisolenoid correction coils on the final quadrupole before the collision point. In this note, we use the interaction region beam dynamics code IRSYN to compute the impact of the SiD solenoid on the beam and benchmark the anti-solenoid correction. We find the correction is achieved, with a small residual amount of beam aberration which is correctable using the beam delivery system. This provides a validation of the correction and a benchmark of IRSYN to existing codes.

  13. Mechanical design of a pre-isolator for the CLIC final focusing magnets

    CERN Document Server

    Gaddi, A; Ramos, F; Siegrist, N

    2012-01-01

    Due to the very small vertical beam sizes, the final focusing elements at the future CLIC linear collider need to be stable against vibrations to below 0.15 nanometres at frequencies above about 4 Hz. One of the key elements in the strategy to achieve such a stable environment is a passive, heavy pre-isolator. In this report, the results from the dynamic finite element analyses of the proposed design for such a passive preisolator are summarized. Furthermore, the results from a low frequency, heavy mass passive vibration isolation test set-up used to validate the calculations are shown.

  14. Measurement of the Higgs decay to electroweak bosons at low and intermediate CLIC energies

    CERN Document Server

    AUTHOR|(SzGeCERN)471575; Milutinovic-Dumbelovic, Gordana; Pandurovic, Mila; Lukic, Strahinja

    2016-01-01

    In this paper a simulation of measurements of the Higgs boson decay to electroweak bosons in $e^+e^-$ collisions at CLIC is presented. Higgs boson production and subsequent $H\\rightarrow ZZ^\\ast$ and $H\\rightarrow WW^\\ast$ decay processes were simulated alongside the relevant background processes at 350 GeV and 1.4 TeV center-of-mass energy. Full detector simulation and event reconstruction were used under realistic beam conditions. The achievable statistical precision of the measured product of the Higgs production cross section and the branching ratio for the analysed decays has been determined.

  15. Dedicated brain PET system of PET/MR for brain research

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Li; Liu, Yaqiang; Ma, Tianyu; Wang, Shi; Wei, Qingyang; Xu, Tianpeng [Institute of Medical Physics, Department of Engineering Physics, Tsinghua University, Beijing (China)

    2015-05-18

    This work is to replace PET ring in human brain PET/MR system with a dedicated wearable PET insert, aimed at improving both patient feasibility and system performance for brain imaging. The designed PET/MR system includes two parts: the inside parts, including a radio frequency (RF) coil and PET ring, are mounted on patient’s head, and the outside part, a MR imager, is dependent of patient. The RF coil is the innermost layer, surrounded by an outer PET-ring layer. They are supported by a MRcompatible structure. And both RF coil and PET detectors are placed inside a standard clinical 3-T MR imager. From the design of the system we can infer that some advantages can be achieved. First, high sensitivity will be achieved with the same amount crystals as the PET ring is more close to region-of-interest area, at a reduced cost. Second, by using a 2-layer depth of interaction (DOI) detector, the parallax effect can be minimized. The resolution will benefit from short positron range caused by magnetic field and smaller ring diameter will also reduce the effect of non-collinearity. Thirdly, as the PET ring is mounted on head, impact of patient motion will be reduced.

  16. DICOM for quantitative imaging biomarker development: a standards based approach to sharing clinical data and structured PET/CT analysis results in head and neck cancer research

    Directory of Open Access Journals (Sweden)

    Andriy Fedorov

    2016-05-01

    Full Text Available Background. Imaging biomarkers hold tremendous promise for precision medicine clinical applications. Development of such biomarkers relies heavily on image post-processing tools for automated image quantitation. Their deployment in the context of clinical research necessitates interoperability with the clinical systems. Comparison with the established outcomes and evaluation tasks motivate integration of the clinical and imaging data, and the use of standardized approaches to support annotation and sharing of the analysis results and semantics. We developed the methodology and tools to support these tasks in Positron Emission Tomography and Computed Tomography (PET/CT quantitative imaging (QI biomarker development applied to head and neck cancer (HNC treatment response assessment, using the Digital Imaging and Communications in Medicine (DICOM® international standard and free open-source software. Methods. Quantitative analysis of PET/CT imaging data collected on patients undergoing treatment for HNC was conducted. Processing steps included Standardized Uptake Value (SUV normalization of the images, segmentation of the tumor using manual and semi-automatic approaches, automatic segmentation of the reference regions, and extraction of the volumetric segmentation-based measurements. Suitable components of the DICOM standard were identified to model the various types of data produced by the analysis. A developer toolkit of conversion routines and an Application Programming Interface (API were contributed and applied to create a standards-based representation of the data. Results. DICOM Real World Value Mapping, Segmentation and Structured Reporting objects were utilized for standards-compliant representation of the PET/CT QI analysis results and relevant clinical data. A number of correction proposals to the standard were developed. The open-source DICOM toolkit (DCMTK was improved to simplify the task of DICOM encoding by introducing new API

  17. DICOM for quantitative imaging biomarker development: a standards based approach to sharing clinical data and structured PET/CT analysis results in head and neck cancer research.

    Science.gov (United States)

    Fedorov, Andriy; Clunie, David; Ulrich, Ethan; Bauer, Christian; Wahle, Andreas; Brown, Bartley; Onken, Michael; Riesmeier, Jörg; Pieper, Steve; Kikinis, Ron; Buatti, John; Beichel, Reinhard R

    2016-01-01

    Background. Imaging biomarkers hold tremendous promise for precision medicine clinical applications. Development of such biomarkers relies heavily on image post-processing tools for automated image quantitation. Their deployment in the context of clinical research necessitates interoperability with the clinical systems. Comparison with the established outcomes and evaluation tasks motivate integration of the clinical and imaging data, and the use of standardized approaches to support annotation and sharing of the analysis results and semantics. We developed the methodology and tools to support these tasks in Positron Emission Tomography and Computed Tomography (PET/CT) quantitative imaging (QI) biomarker development applied to head and neck cancer (HNC) treatment response assessment, using the Digital Imaging and Communications in Medicine (DICOM(®)) international standard and free open-source software. Methods. Quantitative analysis of PET/CT imaging data collected on patients undergoing treatment for HNC was conducted. Processing steps included Standardized Uptake Value (SUV) normalization of the images, segmentation of the tumor using manual and semi-automatic approaches, automatic segmentation of the reference regions, and extraction of the volumetric segmentation-based measurements. Suitable components of the DICOM standard were identified to model the various types of data produced by the analysis. A developer toolkit of conversion routines and an Application Programming Interface (API) were contributed and applied to create a standards-based representation of the data. Results. DICOM Real World Value Mapping, Segmentation and Structured Reporting objects were utilized for standards-compliant representation of the PET/CT QI analysis results and relevant clinical data. A number of correction proposals to the standard were developed. The open-source DICOM toolkit (DCMTK) was improved to simplify the task of DICOM encoding by introducing new API abstractions

  18. Measurement of sigma(ee->Hnunu)xBR(H->tautau) at CLIC @ 1.4 TeV

    CERN Document Server

    Münnich, A.

    2013-01-01

    This detector benchmark study evaluates the statistical precision with which the H -> tautau branching ratio times cross section can be measured at CLIC running at rout(s)= 1.4 TeV. Only the hadronic decays of taus are considered.

  19. The Prototype Inductive Adder With Droop Compensation for the CLIC Kicker Systems

    CERN Document Server

    Holma, J

    2014-01-01

    The Compact Linear Collider (CLIC) study is exploring the scheme for an electron-positron collider with high luminosity and a nominal center-of-mass energy of 3 TeV. The CLIC predamping rings and damping rings (DRs) will produce, through synchrotron radiation, an ultralow emittance beam with high bunch charge. To avoid beam emittance increase, the DR kicker systems must provide extremely flat, high-voltage, pulses. The specifications for the extraction kickers of the DRs are particularly demanding: the flattops of the pulses must be ±12.5 kV with a combined ripple and droop of not more than ±0.02% (±2.5 V). An inductive adder is a very promising approach to meeting the specifications. Recently, a five-layer prototype has been built at CERN. Passive analog modulation has been applied to compensate the voltage droop, for example of the pulse capacitors. The output waveforms of the prototype inductive adder have been compared with predictions of the voltage droop and pulse shape. Conclusions are drawn concern...

  20. A CLIC Damping Wiggler Prototype at ANKA: Commissioning and Preparations for a Beam Dynamics Experimental Program

    CERN Document Server

    Bernhard, Axel; Casalbuoni, Sara; Ferracin, Paolo; Garcia Fajardo, Laura; Gerstl, Stefan; Gethmann, Julian; Grau, Andreas; Huttel, Erhard; Khrushchev, Sergey; Mezentsev, Nikolai; Müller, Anke-Susanne; Papaphilippou, Yannis; Saez de Jauregui, David; Schmickler, Hermann; Schoerling, Daniel; Shkaruba, Vitaliy; Smale, Nigel; Tsukanov, Valery; Zisopoulos, Panagiotis; Zolotarev, Konstantin

    2016-01-01

    In a collaboration between CERN, BINP and KIT a prototype of a superconducting damping wiggler for the CLIC damping rings has been installed at the ANKA synchrotron light source. On the one hand, the foreseen experimental program aims at validating the technical design of the wiggler, particularly the conduction cooling concept applied in its cryostat design, in a long-term study. On the other hand, the wiggler's influence on the beam dynamics particularly in the presence of collective effects is planned to be investigated. ANKA's low-alpha short-bunch operation mode will serve as a model system for these studies on collective effects. To simulate these effects and to make verifiable predictions an accurate model of the ANKA storage ring in low-alpha mode, including the insertion devices is under parallel development. This contribution reports on the first operational experience with the CLIC damping wiggler prototype in the ANKA storage ring and steps towards the planned advanced experimental program with th...

  1. Initial measurements on a prototype inductive adder for the CLIC kicker systems

    CERN Document Server

    Holma, Janne

    2013-01-01

    The CLIC study is exploring the scheme for an electron-positron collider with high luminosity and a nominal centre-of-mass energy of 3 TeV. The CLIC pre-damping rings and damping rings will produce, through synchrotron radiation, ultra-low emittance beam with high bunch charge. To avoid beam emittance increase, the damping ring kicker systems must provide extremely flat, high-voltage, pulses. The specifications for the extraction kickers of the DRs are particularly demanding: the flattops of the pulses must be ±12.5 kV with a combined ripple and droop of not more than ±0.02 % (±2.5 V). An inductive adder is a very promising approach to meeting the specifications. To achieve ultra-flat pulses with a fast rise time the output impedance of the inductive adder needs to be well matched to the system impedance. The parasitic circuit elements of the inductive adder have a significant effect upon the output impedance and these values are very difficult to calculate accurately analytically. To predict these paramet...

  2. Measurements on Prototype Inductive Adders with Ultra-Flat-Top Output Pulses for CLIC DR Kickers

    CERN Document Server

    Holma, J; Belver-Aguilar, C

    2014-01-01

    The CLIC study is investigating the technical feasibility of an electron-positron collider with high luminosity and a nominal centre-of-mass energy of 3 TeV. The CLIC pre-damping rings and damping rings (DRs) will produce ultra-low emittance beam with high bunch charge. To avoid beam emittance increase, the DR kicker systems must provide extremely flat, high-voltage, pulses. The specifications for the DR extraction kickers call for a 160 ns duration flat-top pulses of ±12.5 kV, 250 A, with a combined ripple and droop of not more than ±0.02 % (±2.5 V). An inductive adder is a very promising approach to meeting the specifications because this topology allows the use of both passive and analogue modulation methods to adjust the output waveform. Recently, two five-layer, 3.5 kV, prototype inductive adders have been built at CERN. The first of these has been used to test the passive and active analogue modulation methods to compensate voltage droop and ripple of the output pulses. Pulse waveforms have been reco...

  3. Modelling of Parasitic Inductances of a High Precision Inductive Adder for CLIC

    CERN Document Server

    Holma, J; Ovaska, S J

    2013-01-01

    The CLIC study is exploring the scheme for an electron-positron collider with high luminosity and a nominal centre-of-mass energy of 3 TeV. The CLIC pre-damping rings and damping rings will produce, through synchrotron radiation, ultra-low emittance beam with high bunch charge. To avoid beam emittance increase, the damping ring kicker systems must provide extremely flat, high-voltage, pulses. The specifications for the extraction kickers of the DRs are particularly demanding: the flat-top of the pulses must be ±12.5 kV with a combined ripple and droop of not more than ±0.02 % (±2.5 V). An inductive adder is a very promising approach to meeting the specifications. However, the output impedance of the inductive adder needs to be well matched to the system impedance. The primary leakage inductance, which cannot be computed accurately analytically, has a significant effect upon the output impedance of the inductive adder. This paper presents predictions, obtained by modelling the 3D geometry of the adder struc...

  4. Stabilization and Fine Positioning to the Nanometre Level of the CLIC Main Beam Quadrupoles

    CERN Document Server

    Artoos, K; Fernandez Carmona, P; Guinchard, M; Hauviller, C; Janssens, S; Kuzmin, A; Lackner, F; Leuxe, R; Slaathaug, A

    2010-01-01

    The CLIC main beam quadrupoles need to be stabilized to 1.5 nm integrated R.M.S. displacement at 1 Hz. The choice was made to apply active stabilization with piezoelectric actuators in a rigid support with flexural guides. The advantages of this choice are the robustness against external forces and the possibility to make fast incremental nanometre positioning of the magnet with the same actuators. The study and feasibility demonstration is made in several steps from a single degree of freedom system (s.d.o.f.) with a small mass, a s.d.o.f. with a large mass, leading to the demonstration including the smallest (type 1) and largest (type 4) CLIC main beam quadrupoles. The paper discusses the choices of the position and orientation of the actuators and the tailored rigidities of the flexural hinges in the multi degree of freedom system, and the corresponding MIMO control system. The compatibility with the magnet support and micrometre alignment system is essential. The status of the study and performed tests wi...

  5. CLIC main beam quadrupole active pre-alignment based on cam movers

    CERN Document Server

    Kemppinen, J; Leuxe, R; Mainaud Durand, H; Sandomierski, J; Sosin, M

    2012-01-01

    Compact Linear Collider (CLIC) is a study for a future 48 km long linear electron-positron collider in the multi TeV range. Its target luminosity can only be reached if the main beam quadrupoles (MB quads) are actively pre-aligned within 17 µm in sliding windows of 200 m with respect to a straight reference line. In addition to the positioning requirement, the pre-alignment system has to provide a rigid support for the nano-stabilization system to ensure that the first eigenfrequency is above 100 Hz. Re-adjustment based on cam movers was chosen for detailed studies to meet the stringent pre-alignment requirements. There are four different types of MB quads in CLIC. Their lengths and masses vary so that at least two types of cam movers have to be developed. The validation of the cams with less stringent space restrictions has proceeded to a test setup in 5 degrees of freedom (DOF). Prototypes of the more demanding, smaller cams have been manufactured and they are under tests in 1 DOF. This paper describes the...

  6. Stabilisation and precision pointing quadrupole magnets in the Compact Linear Collider (CLIC)

    CERN Document Server

    Janssens, Stef; van den Brand, Jo; Bertolini, Alessandro; Artoos, Kurt

    This thesis describes the research done to provide stabilisation and precision positioning for the main beam quadrupole magnets of the Compact Linear Collider CLIC. The introduction describes why new particle accelerators are needed to further the knowledge of our universe and why they are linear. A proposed future accelerator is the Compact Linear Collider (CLIC) which consists of a novel two beam accelerator concept. Due to its linearity and subsequent single pass at the interaction point, this new accelerator requires a very small beam size at the interaction point, in order to increase collision effectiveness. One of the technological challenges, to obtain these small beam sizes at the interaction point, is to keep the quadrupole magnets aligned and stable to 1.5 nm integrated r.m.s. in vertical and 5 nm integrated root mean square (r.m.s.) in lateral direction. Additionally there is a proposal to create an intentional offset (max. 50 nm every 20 ms with a precision of +/- 1 nm), for several quadrupole ma...

  7. The aliphatic counterpart of PET, PPT and PBT aromatic polyesters: effect of the molecular structure on thermo-mechanical properties

    Directory of Open Access Journals (Sweden)

    Morgane Albanese

    2016-02-01

    Full Text Available The aliphatic counterparts of the most used aromatic polyesters (PET, PPT, and PBT have been synthesized by a two-stage polycondensation process, starting from dimethyl 1,4-cyclohexane dicarboxylate and different diols. The fully aliphatic polyesters are characterized by two cis/trans isomeric ratios (50 and 90 mol% of the 1,4-cycloaliphatic rings. According to the cis/trans content, the properties of the materials notably change. Indeed, polymers rich in trans isomer are semicrystalline, whereas polymers with low trans content are fully amorphous, due to the presence of kinks along the chain. Trans isomer is characterized by higher rigidity than the cis one and the corresponding polymers have high glass transition temperatures. Moreover, the length of the methylene sequences in the diol has a notable influence on the final thermal and mechanical properties. Therefore, tunable properties can be easily obtained. This characteristic, in association with good mechanical performances, potential sustainability of the monomers and biodegradability, makes these aliphatic polyesters an interesting class of polyesters for some specific applications.

  8. MR-based PET motion correction procedure for simultaneous MR-PET neuroimaging of human brain.

    Directory of Open Access Journals (Sweden)

    Marcus Görge Ullisch

    Full Text Available Positron Emission Tomography (PET images are prone to motion artefacts due to the long acquisition time of PET measurements. Recently, simultaneous magnetic resonance imaging (MRI and PET have become available in the first generation of Hybrid MR-PET scanners. In this work, the elimination of artefacts due to head motion in PET neuroimages is achieved by a new approach utilising MR-based motion tracking in combination with PET list mode data motion correction for simultaneous MR-PET acquisitions. The method comprises accurate MR-based motion measurements, an intra-frame motion minimising and reconstruction time reducing temporal framing algorithm, and a list mode based PET reconstruction which utilises the Ordinary Poisson Algorithm and avoids axial and transaxial compression. Compared to images uncorrected for motion, an increased image quality is shown in phantom as well as in vivo images. In vivo motion corrected images show an evident increase of contrast at the basal ganglia and a good visibility of uptake in tiny structures such as superior colliculi.

  9. Beam Tests of a Prototype Stripline Beam Position Monitoring System for the Drive Beam of the CLIC Two-beam Module at CTF3

    CERN Document Server

    Benot-Morell, Alfonso; Nappa, Jean-Marc; Vilalte, Sebastien; Wendt, Manfred

    2016-01-01

    In collaboration with LAPP and IFIC, two units of a prototype stripline Beam Position Monitor (BPM) for the CLIC Drive Beam (DB), and its associated readout electronics have been successfully installed and tested in the Two-Beam-Module (TBM) at the CLIC Test Facility 3 (CTF3) at CERN. This paper gives a short overview of the BPM system and presents the performance measured under different Drive Beam configurations.

  10. PET studies in epilepsy

    OpenAIRE

    Sarikaya, Ismet

    2015-01-01

    Various PET studies, such as measurements of glucose, serotonin and oxygen metabolism, cerebral blood flow and receptor bindings are availabe for epilepsy. 18Fluoro-2-deoxyglucose (18F-FDG) PET imaging of brain glucose metabolism is a well established and widely available technique. Studies have demonstrated that the sensitivity of interictal FDG-PET is higher than interictal SPECT and similar to ictal SPECT for the lateralization and localization of epileptogenic foci in presurgical patients...

  11. Sensory analysis of pet foods.

    Science.gov (United States)

    Koppel, Kadri

    2014-08-01

    Pet food palatability depends first and foremost on the pet and is related to the pet food sensory properties such as aroma, texture and flavor. Sensory analysis of pet foods may be conducted by humans via descriptive or hedonic analysis, pets via acceptance or preference tests, and through a number of instrumental analysis methods. Sensory analysis of pet foods provides additional information on reasons behind palatable and unpalatable foods as pets lack linguistic capabilities. Furthermore, sensory analysis may be combined with other types of information such as personality and environment factors to increase understanding of acceptable pet foods. Most pet food flavor research is proprietary and, thus, there are a limited number of publications available. Funding opportunities for pet food studies would increase research and publications and this would help raise public awareness of pet food related issues. This mini-review addresses current pet food sensory analysis literature and discusses future challenges and possibilities.

  12. Clinical PET application

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Sang Moo; Hong, Song W.; Choi, Chang W.; Yang, Seong Dae [Korea Cancer Center Hospital, Seoul (Korea)

    1997-12-01

    PET gives various methabolic images, and is very important, new diagnostic modality in clinical oncology. In Korea Cancer Center Hospital, PET is installed as a research tool of long-mid-term atomic research project. For the efficient use of PET for clinical and research projects, income from the patients should be managed to get the raw material, equipment, manpower, and also for the clinical PET research. 1. Support the clinical application of PET in oncology. 2. Budgetary management of income, costs for raw material, equipment, manpower, and the clinical PET research project. In this year, 250 cases of PET images were obtained, which resulted total income of 180,000,000 won. 50,000,000 won was deposited for the 1998 PET clinical research. Second year PET clinical research should be managed under unified project. Increased demand for {sup 18}FDG in and outside KCCH need more than 2 times production of {sup 18}FDG in a day purchase of HPLC pump and {sup 68}Ga pin source which was delayed due to economic crisis, should be done early in 1998. (author). 2 figs., 3 tabs.

  13. Proposition d'une méthode d'alignement de l'accélérateur linéaire CLIC

    CERN Document Server

    Touzé, Thomas; Mainaud-Durand, H

    2011-01-01

    The compact linear collider (CLIC) is the particles accelerator project proposed by the european organization for nuclear research (CERN) for high energy physics after the large hadron collider (LHC). Because of the nanometric scale of the CLIC leptons beams, the emittance growth budget is very tight. It induces alignment tolerances on the positions of the CLIC components that have never been achieved. The last step of the CLIC alignment will be done according to the beam itself. It falls within the competence of the physicists. However, in order to implement the beam-based feedback, a challenging pre-alignment is required : 10 μm at 3σ along a 200 m sliding window. For such a precision, the proposed solution must be compatible with a feedback between the measurement and repositioning systems. The CLIC pre-alignment will have to be active. This thesis does not demonstrate the feasibility of the CLIC active prealignment but shows the way to the last developments that have to be done for that purpose. A metho...

  14. Experimental Verifiction of the CLIC two beam Acceleration Technology in CTF3

    CERN Document Server

    Constance, B; Barranco, J; Corsini, R; Doebert, S; Dubrovskiy, A; Skowronski, P; Tecker, F; Farabolini, W; Persson, T; Lillestol, R; Ikarios, E; Jacewicz, M; Palaia, A; Ruber, R

    2013-01-01

    The Compact Linear Collider international collaboration is pursuing an extensive R&D program towards a multi- TeV electron-positron collider. In particular, the development of two-beam acceleration technology is the focus of the CLIC test facility CTF3. In this paper we summarise the most recent results obtained at CTF3: the results of the studies on the drive beam generation are presented, the achieved two beam acceleration performance is reported and the measured breakdown rates and related observations are summarised. The stability of deceleration process performed over 12 subsequent modules and the comparison of the obtained results with the theoretical expectations are discussed. We also outline and discuss the future experimental program.

  15. Final cross section design of the stripline kicker for the CLIC damping rings

    CERN Document Server

    Belver-Aguilar, C; Barnes, M J; Toral, F

    2012-01-01

    The CLIC design relies on the presence of Pre-Damping Rings (PDR) and Damping Rings (DR) to achieve, through synchrotron radiation, the very low emittance needed to fulfill the luminosity requirements. Kicker systems are required to inject and extract the beam from the Pre-Damping and Damping Rings. In order to achieve both low beam coupling impedance and reasonable broadband impedance matching to the electrical circuit, striplines have been chosen for the kicker elements. In this paper the final design for the DR kicker is presented, including an optimization of the geometric parameters to achieve the requirements for both characteristic impedance and field homogeneity. In addition, a sensitivity analysis of characteristic impedance and field homogeneity to geometric parameters is reported.

  16. Present status of development of damping ring extraction kicker system for CLIC

    CERN Document Server

    Holma, Janne; Belver-Aguilar, Caroline; Faus-Golfe, Angeles; Toral, Fernando

    2012-01-01

    The CLIC damping rings will produce ultra-low emittance beam, with high bunch charge, necessary for the luminosity performance of the collider. To limit the beam emittance blow-up due to oscillations, the pulse power modulators for the damping ring kickers must provide extremely flat, high-voltage pulses: specifications call for a 160 ns duration and a flattop of 12.5 kV, 250 A, with a combined ripple and droop of not more than \\pm0.02 %. The stripline design is also extremely challenging: the field for the damping ring kicker system must be homogenous to within \\pm0.01 % over a 1 mm radius, and low beam coupling impedance is required. The solid-state modulator, the inductive adder, is a very promising approach to meeting the demanding specifications for the field pulse ripple and droop. This paper describes the initial design of the inductive adder and the striplines of the kicker system.

  17. Present status of development of damping ring extraction kicker system for CLIC

    CERN Document Server

    Holma, Janne; Belver-Aguilar, Caroline; Faus-Golfe, Angeles; Toral, Fernando

    2012-01-01

    The CLIC damping rings will produce ultra-low emittance beam, with high bunch charge, necessary for the luminosity performance of the collider. To limit the beam emittance blow-up due to oscillations, the pulse power modulators for the damping ring kickers must provide extremely flat, high-voltage pulses: specifications call for a 160 ns duration and a flattop of 12.5 kV, 250 A, with a combined ripple and droop of not more than ±0.02 %. The stripline design is also extremely challenging: the field for the damping ring kicker system must be homogenous to within ±0.01 % over a 1 mm radius, and low beam coupling impedance is required. The solid-state modulator, the inductive adder, is a very promising approach to meeting the demanding specifications for the field pulse ripple and droop. This paper describes the initial design of the inductive adder and the striplines of the kicker system.

  18. EPS-AG Sacherer Prize: Beam Optics Developments for SPS, RHIC, LHC, CLIC and ATF2

    CERN Document Server

    Tomas, R

    2011-01-01

    Highlights of linear and nonlinear optics studies are presented from various accelerators. At the LHC, optics correction is of critical importance to guarantee safe beam operation. Preparation for LHC opticsmeasurements and corrections has been a major activity during the last decade. In particular, SPS and RHIC have served as excellent research and development machines to test new techniques and instrumentation, such as the measurement of resonance driving terms with and without AC dipoles. Together with a meticulous field quality specification, a careful installation strategy and an elaborate magnet model, these efforts have paid off in the LHC, where a record low beta-beating for hadron colliders below 10% has been achieved. Looking further into the future, the performance of the Final Focus System (FFS) is of critical importance for a future linear collider like CLIC, since it determines the IP beam spot sizes. The large chromatic aberrations required the development of novel non-linear optimization metho...

  19. Multi-step lining-up correction of the CLIC trajectory

    CERN Document Server

    D'Amico, T E

    1999-01-01

    In the CLIC main linac it is very important to minimise the trajectory excursion and consequently the emittance dilution in order to obtain the required luminosity. Several algorithms have been proposed and lately the ballistic method has proved to be very effective. The trajectory correction method described hereafter retains the main advantages of the latter while adding some interesting features. It is based on the separation of the unknown variables like the quadrupole misalignments, the offset and slope of the injection straight line and the misalignments of the beam position monitors (BPM). This is achieved by referring the trajectory relatively to the injection line and not to the average pre-alignment line and by using two trajectories each corresponding to slightly different quadrupole strengths. A reference straight line is then derived onto which the beam is bent by a kick obtained by moving the first quadrupole. The other quadrupoles are then aligned on that line. The quality of the correction dep...

  20. A closer look at the beam-beam processes at ILC and CLIC

    CERN Document Server

    Hartin, Anthony

    2012-01-01

    The strength of the electromagnetic fields in the bunch collision at a linear collider will have a significant effect, yielding large numbers of beamstrahlung photons and associated coherent pair production. These effects are limited in the proposed ILC beam parameters which limit the strength of the bunch field to $\\Upsilon_{\\text{ave}}=0.27$. The CLIC 3 Tev design by comparison has a $\\Upsilon_{\\text{ave}}=3.34$ yielding huge number of coherent pairs. In terms of the precision physics programs of these proposed colliders there is an imperative to investigate the effect of the strong bunch fields on higher order processes. From the exact wavefunctions used in the calculation of transition rates within the Furry interaction picture, and using appropriate simplifications, a multiplicative factor to the coupling constants was obtained. This indicates a significant variation to the transition rate near threshold energies. Further studies are in progress to calculate the exact effect on expected observables.

  1. Design and Manufacture of a Hybrid Final Focus Quadrupole Model for CLIC

    CERN Document Server

    Modena, Michele; Vorozhtsov, Alexey

    2012-01-01

    A tunable hybrid quadrupole magnet design has been proposed for the final focus in the Compact Linear Collider (CLIC) that is currently under study. The proposed design is a combination of an iron dominated electromagnetic quadrupole with a bore diameter of 8.25 mm with permanent magnet blocks placed between the poles made of soft magnetic CoFe alloy "Permendur". The possibility of using Sm2Co17 and Nd2Fe14B as material for the permanent magnet blocks has been investigated. It is shown that a very high field gradient of 530 T/m (Sm2Co17) and 590 T/m (Nd2Fe14B) can be achieved.

  2. Low-level feedback control for the phase regulation of CLIC Drive Beam Klystrons

    CERN Document Server

    AUTHOR|(SzGeCERN)752526

    2015-01-01

    The requirement of luminosity loss below 1% raises tight tolerances for the phase and power stability of the CLIC drive beam (DB) klystrons and consequently for the high voltage pulse ripple of the modulators. A low-level RF (LLRF) feedback system needs to be developed and combined with the modulator in order to guarantee the phase and amplitude tolerances. To this aim, three feedback control strategies were investigated, i) Proportional Integral (PI) controller, ii) Linear Quadratic Integral Regulator (LQI) and iii) Model Predictive Controller (MPC). The klystron, as well as the incident phase noise were modelled and used for the design and evaluation of the controllers. First simulation results are presented along with future steps and directions.

  3. High intensity profile monitor for time resolved spectrometry at the CLIC Test Facility 3

    Science.gov (United States)

    Olvegård, M.; Adli, E.; Braun, H. H.; Bravin, E.; Chritin, N.; Corsini, R.; Dabrowski, A. E.; Döbert, S.; Dutriat, C.; Egger, D.; Lefèvre, T.; Mete, O.; Skowronski, P. K.; Tecker, F.

    2012-08-01

    The power source of the Compact LInear Collider (CLIC) relies on the generation and deceleration of a high-intensity electron drive beam. In order to provide the best radio-frequency (RF) to beam-energy transfer efficiency, the electron beam is accelerated using fully loaded RF cavities, which leads to strong beam loading effects resulting in a high-energy transient. The stability of the RF power produced by the drive beam depends on the stability of the drive beam energy and energy spread along the pulse. The control and the monitoring of the time evolution of the beam energy distribution are therefore crucial for the accelerator performance. For this purpose segmented beam dumps, which are simple and robust devices, have been designed and installed at the CLIC Test Facility 3 (CTF3). These devices are located at the end of spectrometer lines and provide horizontal beam profiles with a time resolution better than 10 ns. The segmented dumps are composed of parallel, vertical, metallic plates, and are based on the same principle as a Faraday cup: the impinging beam current is read by a fast acquisition channel. Both FLUKA and Geant4 simulations were performed to define the optimum detector geometry for beam energies ranging from 5 MeV to 150 MeV. This paper presents a detailed description of the different steps of the design: the optimization of the detector spatial resolution, the minimization of the thermal load and the long-term damage resulting from high radiation doses. Four segmented dumps are currently used in the CTF3 complex. Their measured performance and limitations are presented in this paper. Typical beam spectra as measured in the CTF3 linac are also presented along with a description of the RF manipulations needed for tuning the beam energy spectrum.

  4. Mobile PET Center Project

    Science.gov (United States)

    Ryzhikova, O.; Naumov, N.; Sergienko, V.; Kostylev, V.

    2017-01-01

    Positron emission tomography is the most promising technology to monitor cancer and heart disease treatment. Stationary PET center requires substantial financial resources and time for construction and equipping. The developed mobile solution will allow introducing PET technology quickly without major investments.

  5. Pets and Pasteurella Infections

    Science.gov (United States)

    ... water. When To Call Your Pediatrician If your child is bitten or scratched by a pet, wild animal, or any animal unknown to you, ... allowed to lick very young infants . Teach your child not to approach or touch unfamiliar pets or wild animals and never disturb an animal ...

  6. My Pet Rock

    Science.gov (United States)

    Lark, Adam; Kramp, Robyne; Nurnberger-Haag, Julie

    2008-01-01

    Many teachers and students have experienced the classic pet rock experiment in conjunction with a geology unit. A teacher has students bring in a "pet" rock found outside of school, and the students run geologic tests on the rock. The tests include determining relative hardness using Mohs scale, checking for magnetization, and assessing luster.…

  7. Usage of Recycled Pet

    Directory of Open Access Journals (Sweden)

    A. Ebru Tayyar

    2010-01-01

    Full Text Available The increasing industrialization, urbanization and the technological development have caused to increase depletion of the natural resources and environmental pollution's problem. Especially, for the countries which have not enough space recycling of the waste eliminating waste on regular basis or decreasing the amount and volume of waste have provided the important advantages. There are lots of studies and projects to develop both protect resources and prevent environmental pollution. PET bottles are commonly used in beverage industry and can be reused after physical and chemical recycling processes. Usage areas of recycled PET have been developed rapidly. Although recycled PET is used in plastic industry, composite industry also provides usage alternatives of recycled PET. Textile is a suitable sector for recycling of some plastics made of polymers too. In this study, the recycling technologies and applications of waste PET bottles have been investigated and scientific works in this area have been summarized.

  8. Accelerator and Technical Sector Seminar: Mechanical stabilization and positioning of CLIC quadrupoles with sub-nanometre resolution

    CERN Multimedia

    2011-01-01

    Thursday 24 November 2010 Accelerator and Technical Sector Seminar at 14:15  -  BE Auditorium, bldg. 6 (Meyrin) – please note unusual place Mechanical stabilization and positioning of CLIC quadrupoles with sub-nanometre resolution Stef Janssens /EN-MME Abstract: To reach the required luminosity at the CLIC interaction point, about 4000 quadrupoles are needed to obtain a vertical beam size of 1 nm at the interaction point. The mechanical jitter of the quadrupole magnets will result in an emittance growth. An active vibration isolation system is required to reduce vibrations from the ground and from external forces to about 1.5 nm integrated root mean square (r.m.s.) vertical displacement at 1 Hz. A short overview of vibration damping and isolation strategies will be presented as well as a comparison of existing systems. The unprecedented resolution requirements and the instruments enabling these measurements will be discussed. The vibration sources from which the magnets need to...

  9. Design of the 15 GHz BPM test bench for the CLIC test facility to perform precise stretchedwire RF measurements

    CERN Document Server

    Silvia Zorzetti, Silvia; Galindo Muño, Natalia; Wendt, Manfred

    2015-01-01

    The Compact Linear Collider (CLIC) requires a low emittance beam transport and preservation, thus a precise control of the beam orbit along up to 50 km of the accelerator components in the sub-m regime is required. Within the PACMAN3 (Particle Accelerator Components Metrology and Alignment to the Nanometer Scale) PhD training action a study with the objective of pre-aligning the electrical centre of a 15 GHz cavity beam position monitor (BPM) to the magnetic centre of the main beam quadrupole is initiated. Of particular importance is the design of a specific test bench to study the stretched-wire setup for the CLIC Test Facility (CTF3) BPM, focusing on the aspects of microwave signal excitation, transmission and impedance-matching, as well as the mechanical setup and reproducibility of the measurement method.

  10. CLIC-ACM: generic modular rad-hard data acquisition system based on CERN GBT versatile link

    Science.gov (United States)

    Bielawski, B.; Locci, F.; Magnoni, S.

    2015-01-01

    CLIC is a world-wide collaboration to study the next ``terascale'' lepton collider, relying upon a very innovative concept of two-beam-acceleration. This accelerator, currently under study, will be composed of the subsequence of 21000 two-beam-modules. Each module requires more than 300 analogue and digital signals which need to be acquired and controlled in a synchronous way. CLIC-ACM (Acquisition and Control Module) is the 'generic' control and acquisition module developed to accommodate the controls of all these signals for various sub-systems and related specification in term of data bandwidth, triggering and timing synchronization. This paper describes the system architecture with respect to its radiation-tolerance, power consumption and scalability.

  11. The value of PET, CT and in-line PET/CT in patients with gastrointestinal stromal tumours: long-term outcome of treatment with imatinib mesylate

    Energy Technology Data Exchange (ETDEWEB)

    Goerres, G.W.; Hany, T.F.; Schulthess, G.K. von [University Hospital Zurich, Division of Nuclear Medicine, Zurich (Switzerland); Stupp, R.; Luthi, F.; Leyvraz, S. [University of Lausanne Medical Centre, Multidisciplinary Oncology Centre, Lausanne (Switzerland); Barghouth, G.; Schnyder, P. [University of Lausanne Medical Centre, Department of Radiology, Lausanne (Switzerland); Pestalozzi, B. [University Hospital Zurich, Department of Oncology, Zurich (Switzerland); Dizendorf, E. [University Hospital Zurich, Division of Nuclear Medicine, Zurich (Switzerland); International Tomography Center, Novosibirsk (Russian Federation)

    2005-02-01

    Gastrointestinal stromal tumours (GIST) are mesenchymal neoplasms of the gastrointestinal tract that are unresponsive to standard sarcoma chemotherapy. Imaging of GIST patients is done with structural and functional methods such as contrast-enhanced helical computed tomography (ceCT) and positron emission tomography (PET) with {sup 18}F-fluorodeoxyglucose (FDG). The aim of this study was to compare the prognostic power of PET and ceCT and to evaluate the clinical role of PET/CT imaging. All patients with GIST undergoing PET or PET/CT examinations were prospectively included in this study, and the median overall survival, time to progression and treatment duration were documented. The prognostic significance of PET and ceCT criteria of treatment response was assessed and PET/CT was compared with PET and ceCT imaging. Data for 34 patients (19 male, 15 female, 21-76 years) undergoing PET or PET/CT for staging or restaging were analysed. In 28 patients, PET/CT and ceCT were available after introduction of treatment with the tyrosine kinase inhibitor imatinib mesylate (Gleevec; Novartis, Basel, Switzerland). Patients without FDG uptake after the start of treatment had a better prognosis than patients with residual activity. In contrast, ceCT criteria provided insufficient prognostic power. However, more lesions were found on ceCT images than on PET images, and FDG uptake was sometimes very variable. PET/CT delineated active lesions better than did the combination of PET and ceCT imaging. Both PET and PET/CT provide important prognostic information and have an impact on clinical decision-making in GIST patients. PET/CT precisely delineates lesions and thus allows for the correct planning of surgical interventions. (orig.)

  12. PET/碳纳米管共混物的研究进展%Research progress in PET/carbon nanotube blend

    Institute of Scientific and Technical Information of China (English)

    武荣瑞

    2012-01-01

    综述了聚对苯二甲酸乙二醇酯(PET)/碳纳米管(CNTs)的共混物的制备和性能.官能化CNTs比未官能化CNTs在PET母体中的分散性得到改善;PET/未官能化CNTs共混物和PET/官能化CNTs共混物相比PET,熔融结晶温度均增高,具有更高的结晶度;PET/未官能化CNTs共混物的熔点变化不大,而PET/官能化CNTs共混物的熔点的变化取决于官能化CNTs 中引入官能团的化学结构;PET/未官能化CNTs共混物和PET/官能化CNTs共混物的熔体黏度均比PET有所提高,切力变稀行为比PET也有所增强:PET/未官能化CNTs共混物和PET/官能化CNTs其混物的热稳定性、导电性能及机械性能均得到改善.%The preparation and properties of polyethylene terephthalate (PET)/carbon nanotube(CNTs) blend were reviewed. The dispersion of functionalized CNTs in PET matrix was better than that of non-functionalized CNTs. As compared with PET, PET/non-functionalized CNTs and PET/functionalized CNTs had higher melt crystallization temperature and crystallinity when their thermal stability, conductivity and mechanical properties were improved, the melt viscosity was increased and the shear thinning behavior was enhanced. The melting point of PET/functionalized CNTs blend depended on the chemical structure of functional group in functionalized nanotube when the melting point of PET/non-functionalized CNTs did not change greatly.

  13. Conséquences des perturbations de la gravité sur l'alignement du CLIC

    CERN Document Server

    Becker, F

    1999-01-01

    For the CLIC alignment, the accuracy required for the definition of the geometrical references entails the evaluation of the effects of the Earth's gravity field's disturbances. The distortions of the WPS wires, of the water in the hydrostatic levelling network and of the ground resulting from the Moon and the Sun's attractions and from the neighbouring masses are therefore estimated. Solutions are suggested for the distortions important enough to have to be taken into account.

  14. Physics performance for measurements of chargino and neutralino pair production at a 1.4 TeV CLIC collider

    CERN Document Server

    Roloff, Philipp

    2013-01-01

    A study of chargino and neutralino pair production at a CLIC collider operating at √s = 1.4 TeV is presented. Fully hadronic final states with four jets and missing transverse energy were considered. The analysis was performed using full detector simulation and including pileup from gg → hadrons interactions. Results for the masses and production cross sections of the chargino and the next-to-lightest neutralino are discussed.

  15. 14-3-3和CLIC4蛋白在U251细胞自噬中的相互作用%The interaction of 14-3-3 and CLIC4 proteins in the autophagy of U251 cells

    Institute of Scientific and Technical Information of China (English)

    袁兆新; 金笛; 张宏宇

    2015-01-01

    目的 通过饥饿诱导神经胶质瘤U251细胞发生自噬,探讨细胞CLIC4和14-3-3蛋白在饥饿条件下诱导自噬过程中的相互作用.方法 通过Hoechst、14-3-3 epsilon、CLIC4染色于共聚焦显微镜下观察抑制CLIC4表达对于饥饿条件下,14-3-3 epsilon蛋白与CLIC4共定位的影响.通过Western Blot技术检测Beclin 1及14-3-3蛋白表达.免疫共沉淀技术检测14-3-3 epsilon蛋白与CLIC4蛋白的结合水平.结果 共聚焦显微镜观察14-3-3 epsilon和CLIC4荧光染色结果显示,饥饿条件下,14-3-3 epsilon蛋白与CLIC4共定位显著增加,并广泛分布于胞浆及细胞核中.同时Westem Blot结果表明抑制CLIC4表达能够引起14-3-3蛋白以及自噬相关蛋白Beclin1表达增加.饥饿条件下,14-3-3 epsilon蛋白与CLIC4共沉淀增强,而抑制CLIC4表达能够降低两者结合水平.结论 14-3-3epsilon蛋白与CLIC4的相互作用由于RNA干扰而减弱,促进了14-3-3蛋白水平上调,进而增强了14-3-3蛋白对Beclin1信号通路的调节,引起Beclin1表达增加,进一步激活饥饿条件下U251细胞自噬过程.

  16. Production of S-band Accelerating Structures

    CERN Document Server

    Piel, C; Vogel, H; Vom Stein, P

    2004-01-01

    ACCEL currently produces accelerating structures for several scientific laboratories. Multi-cell cavities at S-band frequencies are required for the projects CLIC-driver-linac, DLS and ASP pre-injector linac and the MAMI-C microtron. Based on those projects differences and similarities in design, production technologies and requirements will be addressed.

  17. Combined PET/MRI

    DEFF Research Database (Denmark)

    Bailey, D. L.; Pichler, B. J.; Gückel, B.;

    2015-01-01

    This paper summarises key themes and discussions from the 4th international workshop dedicated to the advancement of the technical, scientific and clinical applications of combined positron emission tomography (PET)/magnetic resonance imaging (MRI) systems that was held in Tübingen, Germany, from...... February 23 to 27, 2015. Specifically, we summarise the three days of invited presentations from active researchers in this and associated fields augmented by round table discussions and dialogue boards with specific topics. These include the use of PET/MRI in cardiovascular disease, paediatrics, oncology......, neurology and multi-parametric imaging, the latter of which was suggested as a key promoting factor for the wider adoption of integrated PET/MRI. Discussions throughout the workshop and a poll taken on the final day demonstrated that attendees felt more strongly that PET/MRI has further advanced in both...

  18. Birds Kept as Pets

    Science.gov (United States)

    ... Patients Infants and Young Children Publications & Materials Announcements Birds Kept as Pets Recommend on Facebook Tweet Share ... your hands whenever you play or work with birds Person washing their hands with soap and water. ...

  19. PET studies in epilepsy.

    Science.gov (United States)

    Sarikaya, Ismet

    2015-01-01

    Various PET studies, such as measurements of glucose, serotonin and oxygen metabolism, cerebral blood flow and receptor bindings are availabe for epilepsy. (18)Fluoro-2-deoxyglucose ((18)F-FDG) PET imaging of brain glucose metabolism is a well established and widely available technique. Studies have demonstrated that the sensitivity of interictal FDG-PET is higher than interictal SPECT and similar to ictal SPECT for the lateralization and localization of epileptogenic foci in presurgical patients refractory to medical treatments who have noncontributory EEG and MRI. In addition to localizing epileptogenic focus, FDG-PET provide additional important information on the functional status of the rest of the brain. The main limitation of interictal FDG-PET is that it cannot precisely define the surgical margin as the area of hypometabolism usually extends beyond the epileptogenic zone. Various neurotransmitters (GABA, glutamate, opiates, serotonin, dopamine, acethylcholine, and adenosine) and receptor subtypes are involved in epilepsy. PET receptor imaging studies performed in limited centers help to understand the role of neurotransmitters in epileptogenesis, identify epileptic foci and investigate new treatment approaches. PET receptor imaging studies have demonstrated reduced (11)C-flumazenil (GABAA-cBDZ) and (18)F-MPPF (5-HT1A serotonin) and increased (11)C-cerfentanil (mu opiate) and (11)C-MeNTI (delta opiate) bindings in the area of seizure. (11)C-flumazenil has been reported to be more sensitive than FDG-PET for identifying epileptic foci. The area of abnormality on GABAAcBDZ and opiate receptor images is usually smaller and more circumscribed than the area of hypometabolism on FDG images. Studies have demonstrated that (11)C-alpha-methyl-L-tryptophan PET (to study synthesis of serotonin) can detect the epileptic focus within malformations of cortical development and helps in differentiating epileptogenic from non-epileptogenic tubers in patients with tuberous

  20. PET/CT Artifacts

    OpenAIRE

    Blodgett, Todd M.; Mehta, Ajeet S.; Mehta, Amar S.; Laymon, Charles M; Carney, Jonathan; Townsend, David W.

    2011-01-01

    There are several artifacts encountered in PET/CT imaging, including attenuation correction (AC) artifacts associated with using CT for attenuation correction. Several artifacts can mimic a 2-deoxy-2-[18F] fluoro-D-glucose (FDG) avid malignant lesions and therefore recognition of these artifacts is clinically relevant. Our goal was to identify and characterize these artifacts and also discuss some protocol variables that may affect image quality in PET/CT.

  1. Analysis of the Metabolic and Structural Brain Changes in Patients With Torture-Related Post-Traumatic Stress Disorder (TR-PTSD) Using ¹⁸F-FDG PET and MRI.

    Science.gov (United States)

    Zandieh, Shahin; Bernt, Reinhard; Knoll, Peter; Wenzel, Thomas; Hittmair, Karl; Haller, Joerg; Hergan, Klaus; Mirzaei, Siroos

    2016-04-01

    Many people exposed to torture later suffer from torture-related post-traumatic stress disorder (TR-PTSD). The aim of this study was to analyze the morphologic and functional brain changes in patients with TR-PTSD using magnetic resonance imaging (MRI) and positron emission tomography (PET). This study evaluated 19 subjects. Thirteen subcortical brain structures were evaluated using FSL software. On the T1-weighted images, normalized brain volumes were measured using SIENAX software. The study compared the volume of the brain and 13 subcortical structures in 9 patients suffering from TR-PTSD after torture and 10 healthy volunteers (HV). Diffusion-weighted imaging (DWI) was performed in the transverse plane. In addition, the 18F-FDG PET data were evaluated to identify the activity of the elected regions. The mean left hippocampal volume for the TR-PTSD group was significantly lower than in the HV group (post hoc test (Bonferroni) P PTSD and the HV group (post hoc test (Bonferroni) P PTSD group showed low significant expansion of the ventricles in contrast to the HV group (post hoc test (Bonferroni) P PTSD and HV group (post hoc test (Bonferroni) P PTSD, in the temporal lobe in 1 of the 9 patients, and in the caudate nucleus in 5 of the 9 patients. In 2 cases, additional hypometabolism was observed in the posterior cingulate cortex and in the parietal and frontal lobes. The findings from this study show that TR-PTSD might have a deleterious influence on a set of specific brain structures. This study also demonstrated that PET combined with MRI is sensitive in detecting possible metabolic and structural brain changes in TR-PTSD.

  2. Structures and properties of intramolecular flame-retardant PET fibers%分子内阻燃PET纤维的结构性能

    Institute of Scientific and Technical Information of China (English)

    马敬红; 龚静华; 杨曙光; 徐坚

    2012-01-01

    Intramolecular flame-retardant PET resins were prepared via copolymerization reaction by using reactive halogen-free flame retardant CEPPA as a third monomer and then melt spun into flame-retardant PET fibers. The phosphorus content analysis of the flame-retardant PET resins by elementary analysis and NMR showed that the majority of CEPPA were directly reacted into the PET chains. The crystallinity, dyeing behavior, mechanical properties and flammability of the flame-retardant PET fibers were also investigated. The results showed that the crystallinity of the fibers was decreased as increasing the phosphorus content, which led to the improved dyeing properties of the fibers. The dye-uptake of the fibers with disperse dyes under atmosphere pressure and at boiling temperature dyeing was above 90%. Moreover, the flame-retardant PET fibers exhibit superior flame retardance and improved anti-dripping property, with the limiting oxygen index (LOI) value above 35%.%以反应性无卤阻燃剂CEPPA为第3单体,通过共聚改性制备了分子内阻燃PET树脂,并经熔融纺丝纺制阻燃PET纤维.利用元素分析和核磁共振分析了阻燃PET树脂中的磷含量,结果表明,大部分CEPPA聚合到PET分子链中.对阻燃PET纤维的结晶性能、染色行为、力学性能及燃烧性能进行了研究,结果表明,阻燃PET纤维的结晶度随着磷含量的增加而降低,这使得纤维染色性能提高.阻燃PET纤维采用分散染料在常压沸染条件下上染率可达90%.此外纤维具有优异的阻燃性能,极限氧指数(LOI)约为35%,并且抗熔滴性能得到了改善.

  3. Salmonella: Dry Pet Foods and Pet Treats (FAQ)

    Science.gov (United States)

    ... Literature Reviews Market Research Statistics Reference Guides Reports Salmonella: Dry Pet Foods and Pet Treats (FAQ) Originally ... 2008, there was a prolonged multistate outbreak of Salmonella enterica serotype Schwarzengrund infections in humans. A total ...

  4. Design of a new UHV all-metal joint for CLIC

    CERN Document Server

    Lutkiewicz, P; Rathjen, Ch

    2009-01-01

    All-metal joints are widely used in the vacuum systems of particle accelerators. The most common ConFlat® design consists of a flat soft copper gasket captured between two stainless steel flanges with sharp edges (knives). The gasket is plastically deformed and a high contact pressure develops around knives to obtain leak tightness. For large accelerators, a high reliability and a cost-optimized design are required. A smooth internal transition between flanges is needed for the RF waveguides of the compact linear collider (CLIC), with limited deformation of the inner part of the gasket. We present the study of a flange meeting these requirements. First the finite element analysis (FEA) of the Stanford linear accelerator center (SLAC) X-band all-metal joint, which has a similar specification, is shown. Some drawbacks, such as non-homogeneous sealing properties, are highlighted. Then, a new joint design is described. FEA results are presented and are compared with experimental measurements carried out on proto...

  5. High Frequency Effects of Impedances and Coatings in the CLIC Damping Rings

    CERN Document Server

    Koukovini Platia, Eirini; Rumolo, G

    The Compact Linear Collider (CLIC) is a 3 TeV eÅe¡ machine, currently under design at CERN, that targets to explore the terascale particle physics regime. The experiment requires a high luminosity of 2£1034 cm2 s¡1, which can be achieved with ultra low emittances delivered from the Damping Rings (DRs) complex. The high bunch brightness of the DRs gives rise to several collective effects that can limit the machine performance. Impedance studies during the design stage of the DR are of great importance to ensure safe operation under nominal parameters. As a first step, the transverse impedance model of the DRis built, accounting for the wholemachine. Beam dynamics simulations are performedwith HEADTAIL to investigate the effect on beam dynamics. For the correct impedancemodeling of the machine elements, knowledge of the material properties is essential up to hundreds of GHz, where the bunch spectrum extends. Specifically, Non Evaporable Getter (NEG) is a commonly used coating for good vacuumbut its properti...

  6. A Trajectory Correction based on Multi-Step Lining-up for the CLIC Main Linac

    CERN Document Server

    D'Amico, T E

    1999-01-01

    In the CLIC main linac it is very important to minimise the trajectory excursion and consequently the emittance dilution in order to obtain the required luminosity. Several algorithms have been proposed and lately the ballistic method has proved to be very effective. The trajectory method described in this Note retains the main advantages of the latter while adding some interesting features. It is based on the separation of the unknown variables like the quadrupole misalignments, the offset and slope of the injection straight line and the misalignments of the beam position monitors (BPM). This is achieved by referring the trajectory relatively to the injection line and not to the average pre-alignment line and by using two trajectories each corresponding to slightly different quadrupole strengths. A reference straight line is then derived onto which the beam is bent by a kick obtained by moving the first quadrupole. The other quadrupoles are then aligned on that line. The quality of the correction depends mai...

  7. Development and Validation of a Multipoint Based Laser Alignment System for CLIC

    CERN Document Server

    Stern, G; Lackner, F; Mainaud-Durand, H; Piedigrossi, D; Sandomierski, J; Sosin, M; Geiger, A; Guillaume, S

    2013-01-01

    Alignment is one of the major challenges within CLIC study, since all accelerator components have to be aligned with accuracy up to 10 μm over sliding windows of 200 m. So far, the straight line reference concept has been based on stretched wires coupled with Wire Positioning Sensors. This concept should be validated through inter-comparison with an alternative solution. This paper proposes an alternative concept where laser beam acts as straight line reference and optical shutters coupled with cameras visualise the beam. The principle was first validated by a series of tests using low-cost components. Yet, in order to further decrease measurement uncertainty in this validation step, a high-precision automatised micrometric table and reference targets have been added to the setup. The paper presents the results obtained with this new equipment, in terms of measurement precision. In addition, the paper gives an overview of first tests done at long distance (up to 53 m), having emphasis on beam divergence

  8. An Active Pre-Alignment System and Metrology Network for CLIC

    CERN Document Server

    Becker, F; Pittin, R; Wilson, Ian H

    2003-01-01

    The pre-alignment tolerance on the transverse positions of the components of the CLIC linacs is typically ten microns over distances of 200 m. Such tight tolerances cannot be obtained by a static one-time alignment because normal seismic ground movement and cultural noise associated with human and industrial activity quickly creates significant errors. It is therefore foreseen to maintain the components in place using an active-alignment system which will be linked to a permanent metrology and geodetic network. This report describes the overall philosophy and implementation of such a system and proposes one possible solution for active-alignment which uses stepping-motors to move components and stretched-wires as reference lines. Special sensors have been developed to measure the position of the components with respect to the reference lines, and to measure local tilt and relative vertical position. An in-depth analysis has been made of the repercussions on the alignment system of perturbing effects due to th...

  9. Instrumentation for Longitudinal Beam Gymnastics in FEL's and at the CLIC Test Facility 3

    CERN Document Server

    Lefèvre, T; Bravin, E; Burger, S; Corsini, R; Döbert, S; Soby, L; Tecker, F A; Urschutz, P; Welsch, C P; Alesini, D; Biscari, C; Buonomo, B; Coiro, O; Ghigo, A; Marcellini, F; Preger, B; Dabrowski, A; Velasco, M; Craievich, P; Ferianis, M; Veronese, M; Ferrari, A

    2008-01-01

    Built at CERN by an international collaboration, the CLIC Test Facility 3 (CTF3) aims at demonstrating the feasibility of a high luminosity 3 TeV e+-e- collider by the year 2010. One of the main issues to be demonstrated is the generation of a high average current (30 A) high frequency (12 GHz) bunched beam by means of RF manipulation. At the same time, Free Electron Lasers (FEL) are developed in several places all over the world with the aim of providing high brilliance photon sources. These machines rely on the production of high peak current electron bunches. The required performances put high demands on the diagnostic equipment and innovative longitudinal monitors have been developed during the past years. This paper gives an overview of the longitudinal instrumentation developed at ELETTRA and CTF3, where a special effort was made in order to implement at the same time non-intercepting devices for online monitoring, and destructive diagnostics which have the advantage of providing more detailed informati...

  10. The occupancy in the Hadronic Calorimeter endcap of the CLIC detector

    CERN Document Server

    van Dam, S.B.

    2014-01-01

    To achieve the optimal physics performance of a detector for a linear electron–positron col- lider it is essential to minimize the effect of the beam-induced background. Incoherent electron–positron pairs shower in the very forward region of the CLIC detector and cause a too high occupancy of approximately 80% in the inner radius of the HCal endcap. The occupancy is studied by performing full detector simulations and reduced by changing the material and thickness of the support tube that serves as shielding. The effect of the tile size in the HCal endcap is also studied. A minimal occupancy of ⇠ 4% in the HCal inner radius can be reached with a thick tungsten support tube. When taking a more realistic engineering point of view into account and including polyethylene, an occupancy of ⇠ 8% is achieved. These results show that it is possible to reduce the occupancy due to incoherent pairs in the HCal endcap to a similar level as that due to gg ! hadrons events.

  11. Studies of Cs3Sb cathodes for the CLIC drive beam photo injector option

    CERN Document Server

    Martini, Irene; Doebert, Steffen; Fedosseev, Valentine; Hessler, Christoph; Martyanov, Mikhail

    2013-01-01

    Within the CLIC (Compact Linear Collider) project, feasibility studies of a photo injector option for the drive beam as an alternative to its baseline design using a thermionic electron gun are on-going. This R&D program covers both the laser and the photocathode side. Whereas the available laser pulse energy in ultra-violet (UV) is currently limited by the optical defects in the 4thharmonics frequency conversion crystal induced by the0.14 ms long pulse trains, recent measurements of Cs3Sbphotocathodes sensitive to green light showed their potential to overcome this limitation. Moreover, using visible laser beams leads to better stability of produced electron bunches and one can take advantages of the availability of higher quality optics. The studied Cs3Sbphotocathodes have been produced in the CERN photo emission laboratory using the co-deposition technique and tested in a DC gun set-up. The analysis of data acquired during the cathode production process will be presented in this paper, as well as the r...

  12. Numerical simulation for drop impact of PET bottle considering fluid-structure interaction%考虑流固耦合作用的PET瓶跌落碰撞数值仿真

    Institute of Scientific and Technical Information of China (English)

    李强; 刘淑莲; 应光耀; 郑水英

    2012-01-01

    以聚对苯二甲酸乙二醇酯(PET)瓶为研究对象,选用Johnson-Cook本构模型构建PET材料的率相关方程,并根据率相关拉伸实验确定Johnson-Cook方程中的参数.采用Euler法描述流体方程,Lagrange法描述结构方程,应用动力学软件MSC.Dytran中基于混合的Lagrange格式和Euler格式的有限单元和有限体积技术实现流体和结构的耦合作用,完成了贮液PET瓶跌落碰撞过程的数值仿真计算.通过计算,分析PET瓶在碰撞冲击过程中力学行为和能量转化过程,得到碰掩过程中PET瓶底部接触单元不同高度的等效应力时程曲线和最大等效应力随跌落角度、贮液量和壁厚的变化关系,从而分析比较不同跌落高度、跌落角度,贮液量及PET瓶壁厚对PET瓶跌落冲击特性的影响.计算结果表明:随着跌落高度和贮液量的增大,PET瓶所受冲击应力和损伤逐渐增大;冲击应力与壁厚为非线性关系,而与跌落角度呈现强差异性.%With poly ethylene terephthalate (PET) bottle as the research object, the Johnson-Cook equation was chosen to analyze the rate-dependent mechanical properties of PET after its relationship parameters were determined through the rate-dependent tensile experiments. The Euler description was adopted for the fluid domain, and for the structure domain the Lagrange method was used. The computation of the fluid-structure interaction was realized by the method of the MSC. Dytran coupling finite element and finite volume technique based on Lagrange and Euler scheme, and the simulation of the fluid-filled PET bottle in the crash was achieved. Based on numerical calculation, the mechanical behavior and energy conversation process of the PET bottle in the impact were analyzed. The stress time-history curves of contact element at different heights, von Mises stress distribution at various drop angles and the curves for maximum von Mises stress versus liquid quantity, bottle thickness during

  13. Medical application of PET technology

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Sang Moo; Choi, C. W.; An, S. H.; Woo, K. S.; Chung, W. S.; Yang, S. D.; Jun, G. S. and others

    1999-04-01

    We performed following studies using PET technology: 1. Clinical usefulness of [{sup 18}F]FDG whole body PET in malignant disease 2. Clinical usefulness of quantitative evaluation of F-18-FDG 3. Pilot study of C-11 methionine PET in brain tumor 4. PET study in patients with Parkinson's disease 5. A study on the clinical myocardial PET image. PET gives various metabolic information for the living human body, and is very important, new diagnostic modality. The PET study will give us the information of cancer patients such as early detection of cancer, staging, recurrence detection and characterization of cancer. The quantitative analysis using PET could be applied to evaluate the pathophysiology of various diseases and develop new drugs and develop new radiopharmaceuticals.

  14. Fabrication Technologies of the High Gradient Accelerator Structures at 100MV/M Range

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Juwen; /SLAC; Lewandowski, James; /SLAC; Van Pelt, John; /SLAC; Yoneda, Charles; /SLAC; Gudkov, Boris; /CERN; Riddone, Germana; /CERN; Higo, Toshiyasu; /KEK, Tsukuba; Takatomi, Toshikazu; /KEK, Tsukuba

    2012-07-03

    A CERN-SLAC-KEK collaboration on high gradient X-band structure research has been established in order to demonstrate the feasibility of the CLIC baseline design for the main linac stably operating at more than 100 MV/m loaded accelerating gradient. Several prototype CLIC structures were successfully fabricated and high power tested. They operated at 105 MV/m with a breakdown rate that meets the CLIC linear collider specifications of < 5 x 10{sup -7}/pulse/m. This paper summarizes the fabrication technologies including the mechanical design, precision machining, chemical cleaning, diffusion bonding as well as vacuum baking and all related assembly technologies. Also, the tolerances control, tuning and RF characterization will be discussed.

  15. Reproducibility and Reliability of Anti-3-[18F] FACBC Uptake Measurements in Background Structures and Malignant Lesions on Follow-Up PET-CT in Prostate Carcinoma: an Exploratory Analysis

    Science.gov (United States)

    Odewole, Oluwaseun A.; Oyenuga, Oyeladun A.; Tade, Funmilayo; Savir-Baruch, Bital; Nieh, Peter T.; Master, Viraj; Chen, Zhengjia; Wang, Xiaojing; Jani, Ashesh B.; Bellamy, Leah M.; Halkar, Raghuveer K.; Goodman, Mark M.; Schuster, David M.

    2016-01-01

    Purpose The aim of this study is to examine the reproducibility of anti-1-amino-3-[18F]fluorocyclobutane-1-carboxylic acid (anti-3-[18F]FACBC) quantitative measurements in key background structures and untreated malignant lesions. Procedures Retrospective review of 14 patients who underwent follow-up anti-3-[18F]FACBC positron emission tomography-X-ray computed tomography (PET-CT) for prostate carcinoma recurrence. Standard uptake values (SUV) were measured in both original and follow-up scans in key background structures and untreated malignant lesions. Absolute and percent mean difference in SUV between scans and interclass correlation coefficients (ICC) were also computed. Results Mean (±SD, range) scan interval was 17.4 months (±7.1, 4–29). %Mean difference in SUVmean was 0.6 except for early-phase blood pool (ICC=0.4). SUVmax in malignant lesions without interim therapy increased or remained stable over time. Conclusions Despite variable time interval between scans, FACBC PET-CT demonstrates acceptable reproducibility in key background structures. Untreated malignant lesions showed stable or increased uptake over time. A formal test-retest study is planned. PMID:25281411

  16. Influence of Elevated Temperatures on Pet-Concrete Properties

    Science.gov (United States)

    Albano, C.; Camacho, N.; Hernández, M.; Matheus, A.; Gutiérrez, A.

    2008-08-01

    Lightweight aggregate is an important material in reducing the unit weight of concrete complying with special concrete structures of large high-rise buildings. Besides, the use of recycled PET bottles as lightweight aggregate in concrete is an effective contribution for environment preservation. So, the objective of the present work was to study experimentally the flexural strength of the PET -concrete blends and the thermal degradation of the PET in the concrete, when the blends with 10 and 20% in volume of PET were exposed to different temperatures (200, 400, 600 °C). The flexural strength of concrete-PET exposed to a heat source is strongly dependent on the temperature, water/cement ratio, as well as the content and particle size of PET. However, the activation energy is affected by the temperature, location of the PET particles on the slabs and the water/cement ratio. Higher water content originates thermal and hydrolytic degradation on the PET, while on the concrete, a higher vapor pressure which causes an increase in crack formation. The values of the activation energy are higher on the center of the slabs than on the surface, since concrete is a poor heat conductor.

  17. Effect of densification of post-consumer PET fabric on structure and properties of recycled PET chip%废旧PET纺织品致密化对再生PET结构及性能的影响

    Institute of Scientific and Technical Information of China (English)

    严朝; 杨中开; 唐世君; 赵国樑

    2015-01-01

    选用废旧聚酯(PET)布料、经过致密化处理制成半熔融致密料、熔融挤出料和团粒料3种致密化原料,再将废旧PET布料及其致密化原料在相同工艺条件下醇解、再聚合制得再生PET切片;对废旧PET布料、致密化原料及其再生PET切片的结构和性能进行了研究.结果表明:经不同形式致密化处理后,废旧纺织品中PET的特性黏数([η])降低,PET大分子均发生了热降解,其中团粒料伴随有明显的水解,而经半熔融致密化处理后废旧PET中副反应产物最少,不同致密化处理原料的再生PET切片的性能不同,其中以半熔融致密料为原料所得再生PET切片的[η]相对较高,[η]达0.699 dL/g,相对分子质量分布较窄,其相对分子质量分布指数为1.63,端羧基含量为33.29 mol/t,二甘醇质量分数为1.70%,热稳定性能较好.

  18. PET imaging in multiple sclerosis

    NARCIS (Netherlands)

    Faria, Daniele de Paula; Copray, Sjef; Buchpiguel, Carlos; Dierckx, Rudi; de Vries, Erik

    2014-01-01

    Positron emission tomography (PET) is a non-invasive technique for quantitative imaging of biochemical and physiological processes in animals and humans. PET uses probes labeled with a radioactive isotope, called PET tracers, which can bind to or be converted by a specific biological target and thus

  19. Cognitive dysfunction in senior pets.

    Science.gov (United States)

    Crowell-Davis, Sharon L

    2008-02-01

    Aging pets can experience declines in memory, learning, perception, and awareness. These pets may be disoriented, forget previously learned behaviors, develop new fears and anxiety, or change their interactions with people. When these changes are due to cognitive dysfunction, behavioral and environmental adjustments along with medical therapy can slow the progression and keep pets active longer.

  20. Study of the hybrid controller electronics for the nano-stabilization of mechanical vibrations of CLIC quadrupoles

    CERN Document Server

    Fernandez Carmona, P; Collette, C; Esposito, M; Guinchard, M; Janssens, S; Kuzmin, A; Moron Ballester, R

    2011-01-01

    In order to achieve the required levels of luminosity in the CLIC linear collider, mechanical stabilization of quadrupoles to the nanometre level is required. The paper describes a design of hybrid electronics combining an analogue controller and digital communication with the main machine controller. The choice of local analogue control ensures the required low latency while still keeping sufficiently low noise level. Furthermore, it reduces the power consumption, rack space and cost. Sensitivity to radiation single events upsets is reduced compared to a digital controller. The digital part is required for fine tuning and real time monitoring via digitization of critical parameters.

  1. Physics performances for Z' searches at 3 TeV and 1.5 TeV CLIC

    CERN Document Server

    Blaising, Jean-Jacques

    2012-01-01

    Extra neutral gauge bosons (Z') are predicted in many extensions of the Standard Model (SM). In the minimal anomaly-free Z' model (AFZ'), the phenomenology is controlled by only three parameters beyond the SM ones, the Z' mass and two effective coupling constants g'_Y and g'_{BL}. We study the Z' 5-sigma discovery potential in e+e- collisions at 1.4 and 3 TeV CLIC. Assuming LHC discovers a Z' of 5 TeV mass, the expected accuracies on the Z'mu+mu- couplings are presented. We discuss also the requirements on detector performance and beam polarization.

  2. Sensitivity on the Dipole Moments of the τ-Neutrino at e+e- Colliders: ILC and CLIC

    Directory of Open Access Journals (Sweden)

    A. Gutiérrez-Rodríguez

    2014-01-01

    Full Text Available We study the sensitivity on the anomalous magnetic and electric dipole moments of the τ-neutrino at a high-energy and high-luminosity linear electron positron collider, such as the ILC or CLIC, through the reaction e+e-→νν̅γ. We obtain limits on the dipole moments at the future linear colliders energies. For integrated luminosities of 500 fb−1 and center of mass energies between 0.5 and 3 TeV, the future e+e- colliders may improve the existing limits by two or three orders of magnitude.

  3. Some aspects in accelerator structure studies at SLAC

    Institute of Scientific and Technical Information of China (English)

    WANG Ju-Wen

    2009-01-01

    Recent progress in the accelerator structure studies at SLAC is reported.This paper covers the projects including RF deflectors and the LCLS RF gun;the high gradient accelerator R&D in a global CLIC collaboration for the future multi-TeV linear colliders.

  4. PET/MR in oncology

    DEFF Research Database (Denmark)

    Balyasnikova, Svetlana; Löfgren, Johan; de Nijs, Robin

    2012-01-01

    of the challenges inherent in this new technology, but focus on potential applications for simultaneous PET/MR in the field of oncology. Methods and tracers for use with the PET technology will be familiar to most readers of this journal; thus this paper aims to provide a short and basic introduction to a number...... be applied together with PET increasing the amount of information about the tissues of interest. The potential clinical benefit of applying PET/MR in staging, radiotherapy planning and treatment evaluation in oncology, as well as the research perspectives for the use of PET/MR in the development of new...

  5. Choosing a Pet

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    THE capital boasts countless markets of all kinds,but some of its insect,bird and pet markets immortalize Beijing culture and folkloric traditions.Don’t miss it! The Huasheng Tianqiao Market,south of the famous Panjiayuan Antique Market, was moved a few years ago and rebuilt in the

  6. Pets and Parasites

    Science.gov (United States)

    ... to Be SafeTo avoid dog bites, teach your child how to behave around dogs.December 2010September 2000familydoctor.org editorial staffAvoiding SnakebitesRead Article >>Pets and AnimalsAvoiding SnakebitesLearn how to identify, treat, and ...

  7. PET's indsats under lup

    DEFF Research Database (Denmark)

    Hansen, Peer Henrik

    2006-01-01

    En undersøgelseskommission nedsat i 1999. Fem medlemmer skal undersøge PET's efterretningsvirksomhed i forhold til politiske partier, faglige konflikter og politisk ideologiske bevægelser i Danmark under den kolde krig. Kommissionens rapport forventes færdig næste år. Udgivelsesdato: 2. juli 2006...

  8. I Love Petting Zoos!

    Centers for Disease Control (CDC) Podcasts

    2010-03-23

    This Kidtastics podcast helps children learn about how to stay safe and healthy when visiting petting zoos and other animal exhibits.  Created: 3/23/2010 by Centers for Disease Control and Prevention (CDC).   Date Released: 3/23/2010.

  9. Cold Weather Pet Safety

    Science.gov (United States)

    ... they can be knocked over, potentially starting a fire. Check your furnace before the cold weather sets in to make ... avoided because of the risk of burns or fire. Heated pet mats should also be used ... to burrow, get them back inside quickly because they are showing signs of ...

  10. PET and PET/CT in malignant melanoma; PET y PET/CT en melanoma maligno

    Energy Technology Data Exchange (ETDEWEB)

    Garcia O, J.R. [Nuclear Medicine and Molecular Imaging PET/CT, Centro Medico ABC, Mexico D.F. (Mexico)

    2007-07-01

    The advantages that it has the PET/CT are: 1. It diminishes mainly positive false lesions. It identifies physiologic accumulate places. 2. It diminishes in smaller grade false negative. Small injuries. Injuries with low grade concentration. Injure on intense activity areas. 3. Precise anatomical localization of accumulate places. 4. Reduction of the acquisition time. (Author)

  11. Development of Stripline Kickers for Low Emittance Rings: Application to the Beam Extraction Kicker for CLIC Damping Rings

    CERN Document Server

    AUTHOR|(SzGeCERN)728476; Toral Fernandez, Fernando

    In the framework of the design study of Future Linear Colliders, the Compact Linear Collider (CLIC) aims for electron-positron collisions with high luminosity at a nominal centre-of-mass energy of 3 TeV. To achieve the luminosity requirements, Pre-Damping Rings (PDRs) and Damping Rings (DRs) are required: they reduce the beam emittance before the beam is accelerated in the main linac. Several injection and extraction systems are needed to inject and extract the beam from the PDRs and DRs. The work of this Thesis consists of the design, fabrication and laboratory tests of the first stripline kicker prototype for beam extraction from the CLIC DRs, although the methodology proposed can be extended to stripline kickers for any low emittance ring. The excellent field homogeneity required, as well as a good transmission of the high voltage pulse through the electrodes, has been achieved by choosing a novel electrode shape. With this new geometry, it has been possible to benefit from all the advantages that the most...

  12. Cam Mover Alignment System positioning with the Wire Positioning with the Wire Position Sensor Feedback for CLIC

    CERN Document Server

    Kemppinen, Juha

    2016-01-01

    Compact Linear Collider (CLIC) is a study of an electron-positron collider with nominal energy of 3 TeV and luminosity of 2 ∙ 1034 cm-2s-1. The luminosity goal leads to stringent alignment requirements for single quadrupole magnets. Vertical and lateral offset deviations with regards to a given orbit reference in both ends of a quadrupole shall be below 1 μm and quadrupole roll deviation shall be below 100 μrad. Translation in the direction of particle beam is not controlled but mechanically locked. A parallel kinematic platform based on cam movers was chosen as system for detailed studies. Earlier studies have shown that cam movers can reach the CLIC requirements through an iterative process. The paper presents new modular off-the-shelf control electronics and software including three optional positioning algorithms based on iterations as well as a more advanced algorithm which can reach target position in one movement. The advanced algorithm reads wire position sensors (WPS), calculates quadrupole orien...

  13. Analysis of test-beam data with hybrid pixel detector prototypes for the Compact LInear Collider (CLIC) vertex detectors

    CERN Document Server

    Pequegnot, Anne-Laure

    2013-01-01

    The LHC is currently the most powerful accelerator in the world. This proton-proton collider is now stoppped to increase significantly its luminosity and energy, which would provide a larger discovery potential in 2014 and beyond. A high-energy $e^{+}e^{-}$ collider, such as CLIC, is an option to complement and to extend the LHC physics programme. Indeed, a lepton collider gives access to additional physics processes, beyond those observable at the LHC, and therefore provides new discovery potential. It can also provide complementary and/or more precise information about new physics uncovered at the LHC. Many essential features of a detector are required to deliver the full physics potential of this CLIC machine. In this present report, I present my work on the vertex detector R\\&D for this future linear collider, which aims at developping highly granular and ultra-thin position sensitive detection devices with very low power consumption and fast time-stamping capability. We tested here thin silicon pixel...

  14. Fundamentals of PET and PET/CT imaging.

    Science.gov (United States)

    Basu, Sandip; Kwee, Thomas C; Surti, Suleman; Akin, Esma A; Yoo, Don; Alavi, Abass

    2011-06-01

    In this review, the fundamental principles of fluorodeoxyglucose (FDG) positron emission tomography (PET) and FDG PET/computed tomography (CT) imaging have been described. The basic physics of PET instrumentation, radiotracer chemistry, and the artifacts, as well as normal physiological or benign pathological variants, have been described and presented to the readers in a lucid manner to enable them an easy grasp of the fundamentals of the subject. Finally, we have outlined the current developments in quantitative PET imaging, including dual time point and delayed PET imaging, time-of-flight technology in PET imaging and partial volume correction, and global disease assessment with their potential of being incorporated into the assessment of benign and malignant disorders.

  15. New alternatives in construction: earth filled pet bottles

    OpenAIRE

    Ruiz Valencia, Daniel; Pontificia Universidad Javeriana; López Pérez, Cecilia;; Cortes, Eliana; Pontificia Universidad Javeriana; Froese, Andreas; Pontificia Universidad Javeriana

    2014-01-01

    ABSTRACTTwo of the main problems of mankind are the lack of housing and the accumulation of solid waste and garbage thatultimately brings environmental problems. Within this solid waste are plastics such as the PET bottles (for examplesoda bottles). In order to try to solve both problems, since 2001 Eco-Tec Soluciones has pioneered in the constructionof houses and water storage structures with PET bottles filled with rammed earth. Groups GRIME and Estructuras yConstrucción of the Pontificia U...

  16. Proposal to negotiate extensions to four collaboration agreements for the design of key components of the beam-delivery and linac systems for the Compact Linear Collider (CLIC) for a duration of two years

    CERN Document Server

    2017-01-01

    Proposal to negotiate extensions to four collaboration agreements for the design of key components of the beam-delivery and linac systems for the Compact Linear Collider (CLIC) for a duration of two years

  17. Honey-based PET or PET/chitosan fibrous wound dressings: effect of honey on electrospinning process.

    Science.gov (United States)

    Arslan, Aysu; Simşek, Murat; Aldemir, Sevcan Dalkıranoğlu; Kazaroğlu, Nur Merve; Gümüşderelioğlu, Menemşe

    2014-07-01

    In this study, fibrous mats were fabricated via electrospinning from solutions of polyethylene terephthalate (PET), PET/chitosan, and PET/honey at different concentrations. The effect of honey and chitosan on electrospinning process was investigated and compared. Fibers containing chitosan had a beaded or ribbon-like/branched morphology, but this morphology improved in the presence of honey. The diameter of electrospun fibers decreased with an increased ratio of honey in PET solution. In addition, fiber deposition area in the collector increased by increasing the honey content. PET/chitosan and PET/honey fibrous mats reached an equilibrium water content in 15 min and their water uptake capacities, which are important for exudating wounds, were found in the range of 280-430% on dry basis. Cytotoxicity evaluation demonstrated that fibers exhibited no cytotoxic activity. This study discloses that PET fibrous mats especially electrospun in the presence of honey could be proposed as potential wound dressing materials owing to their improved processing abilities besides their suitable structural properties.

  18. Are Pets Good For Us?

    Institute of Scientific and Technical Information of China (English)

    邢连香

    2006-01-01

    A pet animal keeps us feel happy.Pets can staywith us when we are left by ourselves,and pets in-vite us to love and be loved.Often a cat or dog cankeep us easy at time when human words don’t help.Pets also keep us get close to the more natural animalworld.Learning to care for a pet helps a child to growup into a loving man or woman who feels responsible(有责任的) towards those dependent (依靠) on him.A pet dog can make us believe in others for we cansee faithfulness (忠诚) in the dog.In fact,we keeppets not only fo...

  19. PET and Recycling

    Directory of Open Access Journals (Sweden)

    Funda Sevencan

    2007-08-01

    Full Text Available This review aims to clarify the need of decreasing the environmental effects caused by human and draw attention to the increasing environmental effects of plastics wastes. Plastics consist of organic molecules with high density molecules or polymers. Main resources of plastics are the residue of oil rafineries. Several advantages of plastics, have increased the usage continuously. Polyethylene Terephthalate (PET is the most commonly used plastics. PET is used to protect food, drinking water, fruit juice, alcoholic beverage, and food packing films. By the increasing interest on the environmental effects of plastic wastes, concerns on the recyclable packing materials also grew up. Also the daily use of recyclable containers consisting PET have increased. There are five steps for recycling of plastics. These steps are; using large amounts of plastics, collecting them in a big center, classifying and sorting the plastics, reproducing the polymers and obtaining new products with melted plastics. Providing a healthy recycling of plastics, the consumers should have knowledge and responsibility. The consumer should know what he/she has to do before putting the plastics in the recycling containers. Recycling containers and bags should be placed near the sources of plastic wastes. Consequently, the plastic wastes and environmental problems they cause will be on the agenda in future. [TAF Prev Med Bull. 2007; 6(4: 307-312

  20. Pet overpopulation: An economic analysis

    OpenAIRE

    Coate, Stephen; Knight, Brian

    2009-01-01

    This paper considers the problem of pet overpopulation. It develops a tractable dynamic model whose positive predictions square well with key features of the current U.S. market for pets. The model is used to understand, from a welfare economic perspective, the sense in which there is \\overpopulation" of pets and the underlying causes of the problem. The paper also employs the model to consider what policies might be implemented to deal with the problem. A calibrated example is developed to i...

  1. PET radiopharmaceuticals for neuroreceptor imaging

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Routine clinical PET radiopharmaceuticals for the noninvasive imaging of brain receptors, transporters,and enzymes are commonly labeled with positron emitting nuclides such as carbon-11 or fluorine-18. Certain minimal conditions need to be fulfilled for these PET ligands to be used as imaging agents in vivo. Some of these prerequisites are discussed and examples of the most useful clinical PET radiopharmaceuticals that have found application in the central nervous system are reviewed.

  2. Infections That Pets Carry (For Parents)

    Science.gov (United States)

    ... Your 1- to 2-Year-Old Infections That Pets Carry KidsHealth > For Parents > Infections That Pets Carry ... how to protect your family from infections. How Pets Spread Infections Like people, all animals carry germs . ...

  3. Extended suicide with a pet.

    Science.gov (United States)

    Cooke, Brian K

    2013-01-01

    The combination of the killing of a pet and a suicide is a perplexing scenario that is largely unexplored in the literature. Many forensic psychiatrists and psychologists may be unaccustomed to considering the significance of the killing of a pet. The subject is important, however, because many people regard their pets as members of their family. A case is presented of a woman who killed her pet dog and herself by carbon monoxide poisoning. The purpose of this article is to provide an initial exploration of the topic of extended suicide with a pet. Forensic mental health evaluations may have a role in understanding the etiology of this event and in opining as to the culpability of individuals who attempt to or successfully kill a pet and then commit suicide. Because the scientific literature is lacking, there is a need to understand this act from a variety of perspectives. First, a social and anthropological perspective will be presented that summarizes the history of the practice of killing of one's pet, with a focus on the ancient Egyptians. A clinical context will examine what relationship animals have to mental illness. A vast body of existing scientific data showing the relevance of human attachment to pets suggests that conclusions from the phenomena of homicide-suicide and filicide-suicide are applicable to extended suicide with a pet. Finally, recommendations will be proposed for both clinical and forensic psychiatrists faced with similar cases.

  4. STUDY ON PET-PA66 COPOLYMER

    Institute of Scientific and Technical Information of China (English)

    WU Rongrui; SHI Weitong

    1992-01-01

    In this work the PET-PA66 copolymers are obtained. The characterization of chemical structure of copolymer chain by NMR method is also given . It is shown that when the 66 Nylon salt is added in the copolycondensation, the adipic acid and hexamethylenediamine reacted mainly by itself and the obtained copolymer is a random copolymer, and when the Nylon 66 oligomer is added, the obtained copolymer is a block copolymer. The result of NMR analysis is demonstrated by properties investigation.

  5. The Effect of Patient Age on Standardized Uptake Value-Hounsfield Unit Values of Male Genitourinery Structures In F-18 FDG PET/CT

    Directory of Open Access Journals (Sweden)

    Berrin Çavuşoğlu

    2011-12-01

    Full Text Available Objective: Relation between patient age and Hounsfield Unit (HU,which is the linear attenuation coefficient, and Standardized Uptake Values (SUV which is the amount of 18F-fluorodeoxyglucose (F-18 FDG uptake, measured in the areas of interest drawn to prostate, seminal vesicles and testicles in F-18 FDG Positron Emission Tomography/Computed Tomography (PET/CT images was investigated. Material and Methods: Mean and maximum SUV and HU values were recorded from the areas of interest (min 12 mm in diameter which showed FDG uptake in prostate, seminal vesicles and testicles from F-18 FDG PET-CT images of 21 male patients under 40 years without genitourinary cancer. The effect of patient age to SUV and HU values was examined with Pearson correlation test using SPSS program. Results: There was a negative insignificant correlation between patient age and SUV and HU values for prostate. For seminal vesicles, correlation between patient age and SUV values and HUmax were positive but insignificant, while correlation with HUmean was significant (r=0.459, p=0.00. Correlation between patient age and SUVmax and SUVmean values were significant for testicles (r=0.506, p=0.002 and r=0.467, p=0.005, respectively but the correlation between patient age and HUmax and HUmean values was not significant. Conclusion: F-18 FDG uptake in testicles in males increases with age until 40, suggesting an increase in metabolic rate. The significant correlation between age and mean HU values is probably caused by thickening of the tissue without an increase in glucose metabolism in seminal vesicles. In prostate, the effect of patient age to SUV and HU values was not observed until the age 40. (MIRT 2011;20:104-107

  6. Development of a PET Insert for simultaneously small animal PET/MRI

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Yingjie; Zhang, Zhiming; Li, Daowu; Liu, Shuangquan; Wang, Peilin; Feng, Baotong; Chai, Pei; Wei, Long [Division of Nuclear Technology and Applications, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049 (China); Beijing Engineering Research Center of Radiographic Techniques and Equipment, Beijing, 100049 (China)

    2015-05-18

    PET/MR is a new multi-modality imaging system which provide both structural and functional information with good soft tissue imaging ability and no ionizing radiation. In recent years, PET/MR is under major progress because of the development of silicon photomultipliers (SiPM). The goal of this study is to develop a MRI compatible PET insert based on SiPM and LYSO scintillator. The PET system was constituted by the detector ring, electronics and software. The detector ring consists of 16 detector module. The inner diameter of the ring was 151 mm, the external diameter was 216 mm, which was big enough for small animal research, e.g. rat, rabbit and tupaia. The sensor of each module was 2*2 SensL SPMArraySL, coupled with an array of 14 x 14 LYSO crystals, each crystal measuring 2 mm x 2 mm 10 mm. The detector was encapsulated in a copper box for light and magnetic shielding. Resister charge multiplexing circuit was used in the front end electronics. Each detector output 8X and 8Y position signals. One summed timing signal was extracted from the common cathode of all 64 channels. All these signals were transmitted to digital electronic board by a 3 m long coaxial cable from inside of the MR to the outside. Each digital electronic board handled 8 detector modules based on FPGA to obtain the timing, position and energy information of a single event. And then these single events were sent to the coincidence processing board to produce coincidence packets which are prepared for further processing. A 0.2mCi 68Ge line source was used to do the preliminary imaging test. The image was reconstructed by 3D-OSEM algorithm. The initial result proved the system to be feasible as a PET. FDG phantom imaging and simultaneous PET/MR imaging are in progress.

  7. Um CLIC para perpetuar a felicidade clandestina: reflexões sobre mediação de leitura

    OpenAIRE

    Zancani, Cristine Lima

    2008-01-01

    Esta tese, intitulada Para perpetuar a felicidade clandestina: reflexões sobre mediação de leitura, tem como objeto de estudo a mediação de leitura, a partir da figura do mediador que atua no CLIC, projeto de pesquisa inserido no Programa de Pós-Graduação em Letras da Pontifícia Universidade Católica do Rio Grande do Sul / PUCRS. A trajetória de formação do mediador de leitura começa quando, ao ouvir ou ler histórias, identifica esse momento como fonte de prazer. Tal constatação parte de uma ...

  8. Design and Manufacturing Description of the Prototype Striplines for the Extraction Kicker of the CLIC Damping Rings

    CERN Document Server

    Belver-Aguilar, C; Faus-Golfe, A; Gómez, J; Gutiérrez, D; Toral, F

    2013-01-01

    The Pre-Damping Rings (PDRs) and Damping Rings (DRs) of CLIC are needed to reduce the beam emittances to the small values required for the main linacs. The injection and extraction, from the PDRs and DRs, are carried out by kicker systems. In order to achieve both low beam coupling impedance and reasonable broadband impedance matching to the electrical circuit, striplines have been chosen for the kicker elements. The design of the stripline kicker was previously carried out by modelling the striplines with simulation codes such as HFSS, Quickfield and CST Particle Studio. In order to have a complete analysis of the striplines, the effect of electrode supports and coaxial feedthroughs have been studied in detail. In this paper, electromagnetic analyses of the complete striplines, including fabrication tolerances, are reported. Furthermore, a new idea for impedance matching is presented.

  9. Theoretical and practical feasibility demonstration of a micrometric remotely controlled pre-alignment system for the CLIC linear collider

    CERN Document Server

    Mainaud Durand, H; Chritin, N; Griffet, S; Kemppinen, J; Sosin, M; Touze, T

    2011-01-01

    The active pre-alignment of the Compact Linear Collider (CLIC) is one of the key points of the project: the components must be pre-aligned w.r.t. a straight line within a few microns over a sliding window of 200 m, along the two linacs of 20 km each. The proposed solution consists of stretched wires of more than 200 m, overlapping over half of their length, which will be the reference of alignment. Wire Positioning Sensors (WPS), coupled to the supports to be pre-aligned, will perform precise and accurate measurements within a few microns w.r.t. these wires. A micrometric fiducialisation of the components and a micrometric alignment of the components on common supports will make the strategy of pre-alignment complete. In this paper, the global strategy of active pre-alignment is detailed and illustrated by the latest results demonstrating the feasibility of the proposed solution.

  10. Development of a Bunch Frequency Monitor for the Preliminary Phase of the CLIC Test Facility CTF3

    CERN Document Server

    Caspers, Friedhelm; Ferrari, A; Rinolfi, Louis; Royer, P; Rydberg, A; Tecker, F A

    2003-01-01

    In the framework of the CLIC RF power source studies, the feasibility of the electron bunch train combination by injection with RF deflectors into an isochronous ring has been successfully demonstrated in the preliminary phase of CTF3. A new method, based on beam frequency spectrum analysis, was experimented to monitor this scheme. A coaxial pick-up and its read-out electronics were designed and mounted in the CTF3 ring to allow comparison of the amplitudes of five harmonics of the fundamental beam frequency (3 GHz) while combining the bunch trains. The commissioning of the monitor was a successful proof of principle for this new method, despite the short length of the bunch trains and the presence of parasitic signals associated to high-order waveguide modes propagating with the beam inside the pipe.

  11. Study of the electronics architecture for the mechanical stabilisation of the quadrupoles of the CLIC linear accelerator

    CERN Document Server

    Artoos, K; Fernandez Carmona, P; Guinchard, M; Hauviller, C; Janssens, S; Kuzmin, A; Slaathaug, A

    2010-01-01

    To reach a sufficient luminosity, the transverse beam sizes and emittances in future linear particle accelerators should be reduced to the nanometer level. Mechanical stabilisation of the quadrupole magnets is of the utmost importance for this. The piezo actuators used for this purpose can also be used to make fast incremental orientation adjustments with a nanometer resolution. The main requirements for the CLIC stabilisation electronics is a robust, low noise, low delay, high accuracy and resolution, low band and radiation resistant feedback control loop. Due to the high number of controllers (about 4000) a cost optimization should also be made. Different architectures are evaluated for a magnet stabilisation prototype, including the sensors type and configuration, partition between software and hardware for control algorithms, and optimization of the ADC/DAC converters. The controllers will be distributed along the 50 km long accelerator and a communication bus should allow external control. Furthermore, o...

  12. Development of an Eccentric CAM Based Active Pre-Alignment System for the CLIC Main Beam Quadrupole Magnet

    CERN Document Server

    Lackner, F; Collette, C; Mainaud Durand, H; Hauviller, C; Kemppinen, J; Leuxe, R

    2010-01-01

    CLIC (Compact Linear Collider) is a study for a future electron-positron collider that would allow physicists to explore a new energy region beyond the capabilities of today's particle accelerators. The demanding transverse and vertical beam sizes and emittance specifications are resulting in stringent alignment and a nanometre stability requirement. In the current feasibility study, the main beam quadrupole magnets have to be actively pre-aligned with a precision of 1 µm in 5 degrees of freedom (d.o.f.) before being mechanically stabilized to the nm scale above 1 Hz. This contribution describes the approach of performing this active pre-alignment based on an eccentric cam system. In order to limit the amplification of the vibration sources at resonant frequencies a sufficiently high Eigenfrequency is required. Therefore the contact region between cam and support was optimized for adequate stiffness based on the Hertzian theory. Furthermore, practical tests performed on a single degree of freedom mock-up wil...

  13. Alignement général du CLIC: stratégie et progrès

    CERN Document Server

    Mainaud-Durand, H

    2008-01-01

    La faisabilité concernant le pré-alignement actif du CLIC sera démontrée si l?on peut prouver qu?il existe une référence et ses capteurs associés permettant l?alignement des composants à mieux que 3 microns (1?). Pour répondre à ce challenge, une méthode de mesure d?écarts à un fil tendu est proposée, basée sur 40 ans de pratique de cette technique au CERN. Quelques problèmes demeurent concernant cette méthode : la connaissance de la forme du fil tendu utilisé comme référence droite, la détermination du géoïde à la précision souhaitée et le développement de capteurs bas coût permettant des mesures sub-micrométriques. Des études ont été entreprises afin de lever les derniers points en suspens, pendant que cette solution est intégrée dans une proposition concernant l?alignement général du CLIC. Cela implique un grand nombre d?interactions au niveau du projet, dans des domaines aussi différents que le génie civil, l?intégration, la physique du faisceau, la métrologie des �...

  14. Neurotransmission imaging by PET

    Energy Technology Data Exchange (ETDEWEB)

    Takano, Akihiro; Suhara, Tetsuya [National Inst. of Radiological Sciences, Chiba (Japan)

    2001-08-01

    PET studies on neurotransmission in psychological disorders to evaluate abnormal neurotransmission and therapeutic effects are thoroughly reviewed by type of major neurotransmitters. Studies on dopaminergic neurotransmission have focused on the function of dopamine D{sub 2} receptors, receptor subtypes, such as the D{sub 1} receptor, and ligands, such as transporters. PET studies of dopamine D{sub 2} receptor, which began in the early 1980s, have predominantly been performed in schizophrenia, and most have failed to detect any statistically significant differences between schizophrenia patients and controls. The studies in the early 1980s were performed by using [{sup 11}C]N-methyl-spiperone (NMSP) and [{sup 11}C]raclopride, ligands for striatal dopamine D{sub 2} receptors. [{sup 11}C]FLB457, which has much higher affinity for D{sub 2} receptors than raclopride, began to be used in the 1990s. Dopamine D{sub 2} occupancy after drug ingestion has also been investigated to clarify the mechanisms and effects of antipsychotic drugs, and there have also been studies on the effect of aging and personality traits on dopamine D{sub 2} receptor levels in healthy subjects. In studies on dopamine receptor subtypes other than D{sub 2}, dopamine D{sub 1} receptors have been studied in connection with assessments of cognitive functions. Most studies on dopamine transporters have been related to drug dependence. Serotonin 5-HT{sub 2A} receptors have been studied with [{sup 11}C]NMSP in schizophrenia patients, while studies of another serotonin receptor subtype, 5-HT{sub 1A} receptors, have been mainly conducted in patients with depression. [{sup 11}C]NMSP PET showed no difference between schizophrenia patients who had not undergone phamacotherapy and normal subjects. Because serotonin selective reuptake inhibitors (SSRIs) affect serotonin transporters, and abnormalities in serotonin transporters detected in mood disorders, PET ligands for serotonin transporters have increasingly

  15. Small Molecule PET-Radiopharmaceuticals

    NARCIS (Netherlands)

    Elsinga, Philip H.; Dierckx, Rudi A. J. O.

    2014-01-01

    This review describes several aspects required for the development of small molecule PET-tracers. Design and selection criteria are important to consider before starting to develop novel PET-tracers. Principles and latest trends in C-11 and F-18-radiochemistry are summarized. In addition an update o

  16. Supplements for exotic pets.

    Science.gov (United States)

    Mejia-Fava, Johanna; Colitz, Carmen M H

    2014-09-01

    The use of supplements has become commonplace in an effort to complement traditional therapy and as part of long-term preventive health plans. This article discusses historical and present uses of antioxidants, vitamins, and herbs. By complementing traditional medicine with holistic and alternative nutrition and supplements, the overall health and wellness of exotic pets can be enhanced and balanced. Further research is needed for understanding the strengths and uses of supplements in exotic species. Going back to the animals' origin and roots bring clinicians closer to nature and its healing powers.

  17. PET and PET/CT - relevance in breast cancer patients; PET und PET/CT - Stellenwert beim Mammakarzinom

    Energy Technology Data Exchange (ETDEWEB)

    Palmedo, H. [Klinik und Poliklinik fuer Nuklearmedizin, Universitaetsklinikum Bonn (Germany)

    2004-12-01

    Breast cancer is the most frequent malignant tumor of women in Germany. In spite of an increasing incidence mortality has slightly declined most likely due to improvements in diagnosis and therapy of the disease. FDG-PET has a high diagnostic accuracy for the detection of lymph node and distant metastases. However, PET is no alternative to axillary dissection or sentinel node biopsy because sensitivity for small lymph node metastases is limited. For N-staging, FDG-PET delivers valuable information if mammaria-interna or mediastinal lymph node disease has to be proven (1b-indication). Individually, PET can add important diagnostic information in patients with suspected distant metastases but unsuspicious or equivocal conventional imaging (2-indication). FDG-PET shows unique and favourable properties for early therapy monitoring during preoperative chemotherapy. Larger studies have to confirm these results. (orig.)

  18. Framework for the construction of a Monte Carlo simulated brain PET-MR image database

    Science.gov (United States)

    Thomas, B. A.; Erlandsson, K.; Drobnjak, I.; Pedemonte, S.; Vunckx, K.; Bousse, A.; Reilhac-Laborde, A.; Ourselin, S.; Hutton, B. F.

    2014-01-01

    Simultaneous PET-MR acquisition reduces the possibility of registration mismatch between the two modalities. This facilitates the application of techniques, either during reconstruction or post-reconstruction, that aim to improve the PET resolution by utilising structural information provided by MR. However, in order to validate such methods for brain PET-MR studies it is desirable to evaluate the performance using data where the ground truth is known. In this work, we present a framework for the production of datasets where simulations of both the PET and MR, based on real data, are generated such that reconstruction and post-reconstruction approaches can be fairly compared.

  19. Issues and Feasibility Demonstration of Positioning Closed Loop Control for the CLIC Supporting System Using a Test Mock-up with Five Degrees of Freedom

    CERN Document Server

    Sosin, M; Chritin, N; Griffet, S; Kemppinen, J; Mainaud Durand, H; Rude, V; Sterbini, G

    2012-01-01

    Since several years, CERN is studying the feasibility of building a high energy e+ e- linear collider: the CLIC (Compact LInear Collider). One of the challenges of such a collider is the pre-alignment precision and accuracy requirement on the transverse positions of the linac components, which is typically 14 μm over a window of 200 m. To ensure the possibility of positioning within such tight constraints, CERN Beams Department’s Survey team has worked intensively at developing the methods and technology needed to achieve that objective. This paper describes activities which were performed on a test bench (mock-up) with five degrees of freedom (DOF) for the qualification of control algorithms for the CLIC supporting system active-pre-alignment. Present understanding, lessons learned (“know how”), issues of sensors noise and mechanical components nonlinearities are presented.

  20. Alignment Methods Developed for the Validation of the Thermal and Mechanical Behaviour of the Two Beam Test Modules for the CLIC Project

    CERN Document Server

    Mainaud Durand, Helene; Sosin, Mateusz; Rude, Vivien

    2014-01-01

    CLIC project will consist of more than 20 000 two meters long modules. A test setup made of three modules is being built at CERN to validate the assembly and integration of all components and technical systems and to validate the short range strategy of pre-alignment. The test setup has been installed in a room equipped with a sophisticated system of ventilation able to reproduce the environmental conditions of the CLIC tunnel. Some of the components have been equipped with electrical heaters to simulate the power dissipation, combined with a water cooling system integrated in the RF components. Using these installations, to have a better understanding of the thermal and mechanical behaviour of a module under different operation modes, machine cycles have been simulated; the misalignment of the components and their supports has been observed. This paper describes the measurements methods developed for such a project and the results obtained.

  1. Fusion of PET and MRI for Hybrid Imaging

    Science.gov (United States)

    Cho, Zang-Hee; Son, Young-Don; Kim, Young-Bo; Yoo, Seung-Schik

    Recently, the development of the fusion PET-MRI system has been actively studied to meet the increasing demand for integrated molecular and anatomical imaging. MRI can provide detailed anatomical information on the brain, such as the locations of gray and white matter, blood vessels, axonal tracts with high resolution, while PET can measure molecular and genetic information, such as glucose metabolism, neurotransmitter-neuroreceptor binding and affinity, protein-protein interactions, and gene trafficking among biological tissues. State-of-the-art MRI systems, such as the 7.0 T whole-body MRI, now can visualize super-fine structures including neuronal bundles in the pons, fine blood vessels (such as lenticulostriate arteries) without invasive contrast agents, in vivo hippocampal substructures, and substantia nigra with excellent image contrast. High-resolution PET, known as High-Resolution Research Tomograph (HRRT), is a brain-dedicated system capable of imaging minute changes of chemicals, such as neurotransmitters and -receptors, with high spatial resolution and sensitivity. The synergistic power of the two, i.e., ultra high-resolution anatomical information offered by a 7.0 T MRI system combined with the high-sensitivity molecular information offered by HRRT-PET, will significantly elevate the level of our current understanding of the human brain, one of the most delicate, complex, and mysterious biological organs. This chapter introduces MRI, PET, and PET-MRI fusion system, and its algorithms are discussed in detail.

  2. Sparsity-constrained PET image reconstruction with learned dictionaries

    Science.gov (United States)

    Tang, Jing; Yang, Bao; Wang, Yanhua; Ying, Leslie

    2016-09-01

    PET imaging plays an important role in scientific and clinical measurement of biochemical and physiological processes. Model-based PET image reconstruction such as the iterative expectation maximization algorithm seeking the maximum likelihood solution leads to increased noise. The maximum a posteriori (MAP) estimate removes divergence at higher iterations. However, a conventional smoothing prior or a total-variation (TV) prior in a MAP reconstruction algorithm causes over smoothing or blocky artifacts in the reconstructed images. We propose to use dictionary learning (DL) based sparse signal representation in the formation of the prior for MAP PET image reconstruction. The dictionary to sparsify the PET images in the reconstruction process is learned from various training images including the corresponding MR structural image and a self-created hollow sphere. Using simulated and patient brain PET data with corresponding MR images, we study the performance of the DL-MAP algorithm and compare it quantitatively with a conventional MAP algorithm, a TV-MAP algorithm, and a patch-based algorithm. The DL-MAP algorithm achieves improved bias and contrast (or regional mean values) at comparable noise to what the other MAP algorithms acquire. The dictionary learned from the hollow sphere leads to similar results as the dictionary learned from the corresponding MR image. Achieving robust performance in various noise-level simulation and patient studies, the DL-MAP algorithm with a general dictionary demonstrates its potential in quantitative PET imaging.

  3. FDG PET imaging dementia

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Byeong Cheol [Kyungpook National University Medical School and Kyungpook National University Hospital, Daegu (Korea, Republic of)

    2007-04-15

    Dementia is a major burden for many countries including South Korea, where life expectancy is continuously growing and the proportion of aged people is rapidly growing. Neurodegenerative disorders, such as, Alzheimer disease, dementia with Lewy bodies, frontotemporal dementia. Parkinson disease, progressive supranuclear palsy, corticobasal degeneration, Huntington disease, can cause dementia, and cerebrovascular disease also can cause dementia. Depression or hypothyroidism also can cause cognitive deficits, but they are reversible by management of underlying cause unlike the forementioned dementias. Therefore these are called pseudodementia. We are entering an era of dementia care that will be based upon the identification of potentially modifiable risk factors and early disease markers, and the application of new drugs postpone progression of dementias or target specific proteins that cause dementia. Efficient pharmacologic treatment of dementia needs not only to distinguish underlying causes of dementia but also to be installed as soon as possible. Therefore, differential diagnosis and early diagnosis of dementia are utmost importance. F-18 FDG PET is useful for clarifying dementing diseases and is also useful for early detection of the disease. Purpose of this article is to review the current value of FDG PET for dementing diseases including differential diagnosis of dementia and prediction of evolving dementia.

  4. Conversion efficiency and luminosity for gamma-proton colliders based on the LHC-CLIC or LHC-ILC QCD explorer scheme

    Energy Technology Data Exchange (ETDEWEB)

    Aksakal, H. [Department of Physics, Faculty of Science, Ankara University, 06100 Tandogan, Ankara (Turkey) and Department of Physics, Faculty of Art and Science, Nigde University, 51200 Nigde (Turkey)]. E-mail: aksakal@science.ankara.edu.tr; Ciftci, A.K. [Department of Physics, Faculty of Science, Ankara University, 06100 Tandogan, Ankara (Turkey); Nergiz, Z. [Department of Physics, Faculty of Science, Ankara University, 06100 Tandogan, Ankara (Turkey); Department of Physics, Faculty of Art and Science, Nigde University, 51200 Nigde (Turkey); Schulte, D. [CERN, 1211, Geneva 23 (Switzerland); Zimmermann, F. [CERN, 1211, Geneva 23 (Switzerland)

    2007-06-21

    Gamma-proton collisions allow unprecedented investigations of the low x and high Q{sup 2} regions in quantum chromodynamics. In this paper, we investigate the luminosity for ''ILC''xLHC(s{sub ep}=1.3TeV) and ''CLIC''xLHC(s{sub ep}=1.45TeV) based {gamma}p colliders. Also we determine the laser properties required for high conversion efficiency.

  5. 36 CFR 2.15 - Pets.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Pets. 2.15 Section 2.15 Parks... USE AND RECREATION § 2.15 Pets. (a) The following are prohibited: (1) Possessing a pet in a public... area closed to the possession of pets by the superintendent. This subparagraph shall not apply to...

  6. 36 CFR 1002.15 - Pets.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Pets. 1002.15 Section 1002.15....15 Pets. (a) The following are prohibited: (1) Possessing a pet in a public building, public... possession of pets by the Board. This paragraph shall not apply to guide dogs accompanying visually...

  7. 7 CFR 502.11 - Pets.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Pets. 502.11 Section 502.11 Agriculture Regulations of... CONDUCT ON BELTSVILLE AGRICULTURE RESEARCH CENTER PROPERTY, BELTSVILLE, MARYLAND § 502.11 Pets. Pets... vaccinations. Pets that are the property of employees residing on BARC must be up to date on their...

  8. Assessment of PET & ASL metabolism in the hippocampal subfields of MCI and AD using simultaneous PET-MR

    Energy Technology Data Exchange (ETDEWEB)

    Goubran, Maged; Douglas, David; Chao, Steven; Quon, Andrew; Tripathi, Pragya; Holley, Dawn; Vasanawala, Minal; Zaharchuk, Greg; Zeineh, Michael [Stanford University (United States)

    2015-05-18

    Alzheimer’s disease (AD) has been reported to show decreased metabolic activity in the hippocampus using FDG PET-MR. Histological data suggests that the hippocampal subfields are selectively affected in AD. Given the simultaneous imaging nature of integrated PET-MR scanners and the multimodal capabilities of PET-MR, our purpose here is to assess FDG activity, as well as ASL perfusion in the subfields of MCI and AD patients. 10 consecutive subjects were recruited for this study 3 MCI, 3 AD patients and 4 age-matched controls. The scanning was performed on a simultaneous 3T PET/MR scanner. To delineate the hippocampal subfields, automatic segmentation of hippocampal subfields (ASHS) was employed. Static FDG-PET series were reconstructed for analysis at 45-75 min for all subjects. All imaging sequences were automatically registered to the oblique coronal T2-weighted images (segmentation space). PET standardized uptake values (SUV) in the hippocampal subfields were normalized by the pons. FDG PET metabolism was reduced significantly in AD, as well as MCI patients as compared to controls, with the highest effect demonstrated in the CA3/DG and CA1/2 (p = 0.047, subfields. Patients (MCI and AD combined) had decreased metabolism as compared to controls in CA1/2 and significantly smaller volumes the Subiculum. When assessing CBF across groups, a significant decrease in CBF was found in the Subiculum. Our preliminary results demonstrate that PET-MRI may potentially be a sensitive biomarker and tool for early diagnosis of AD. They also confirm the importance of assessing metabolic and structural changes of neurodegenerative diseases at the subfield level.

  9. PET-Based Thoracic Radiation Oncology.

    Science.gov (United States)

    Simone, Charles B; Houshmand, Sina; Kalbasi, Anusha; Salavati, Ali; Alavi, Abass

    2016-07-01

    Fluorodeoxyglucose-PET is increasingly being integrated into multiple aspects of oncology. PET/computed tomography (PET/CT) has become especially important in radiation oncology. With the increasing use of advanced techniques like intensity-modulated radiation therapy and proton therapy, PET/CT scans have played critical roles in the target delineation of tumors for radiation oncologists delivering conformal treatment techniques. Use of PET/CT is well established in lung cancer and several other thoracic malignancies. This article details the current uses of PET/CT in thoracic radiation oncology with a focus on lung cancer and describes expected future roles of PET/CT for thoracic tumors.

  10. PRIMARY STUDY ON BLENDS BASED ON THERMOTROPIC LIQUID CRYSTAL COPOLYESTER AND PET

    Institute of Scientific and Technical Information of China (English)

    WU Liheng; ZHANG Guoyao; YI Guozhen; LIU Dong

    1992-01-01

    The blend system composed of PET and thermotropic liquid crystal copolyester based on hydroxy benzoic acid, terephthalic acid, diacetyinaphthalene and PET was studied. The results indicated that LCP could play the role of crystal nuclei. The introduction of LCP decreased the melt viscosity of the system and fibrillous structure could be formed in favor conditions.

  11. Topography of pulmonary structure and function in man using positron emission tomography (PET) with special reference to methodology and normal physiology

    Energy Technology Data Exchange (ETDEWEB)

    Brundin, L.H. [MRC, Cyclotron Unit and Dept. of Medicine, Hammersmith Hospital, London (United Kingdom) and Lund Univ. (Sweden). Dept. of Clinical Physiology

    1992-12-31

    Positron emission tomography (PET) allows regional quantification of specific tracer compounds to be made within a tomographic slice of the body. The present thesis which is methodological and descriptive, centers on in vivo measurements of regional lung compartments (gas, red cells, plasma and extravascular tissue) and ventilation and blood flow in normal subjects. A method of measuring regional lung hematocrit (rH) was developed and rH was found to be found to be 90% of the peripheral hematocrit in normal subjects. No significant regional variations within the lung fields were found in normal subjects or in patients with anemia or pneumonia, which enables the pulmonary whole blood volume to be regionally quantified using a single vascular tracer. This allowed a deeper examination of the interrelationship between the different lung compartments and their variation in the gravity dependent axis and during hyperinflation. Smokers were found to have higher extravascular density than non-smokers. By combining measurement of ventilation and {sup .}V{sub A}/{sup .}Q, methods were developed to 1. correct the measured {sup .}V{sub A}/{sup .}Q for incomplete equilibrium of {sup 13}N within the alveolar space. 2. calculate regional pulmonary perfusion. By further combining these measurements with measurements of vascular and extravascular lung volumes 1. relationship between ventilation and vascular and extravascular volumes were explored and found to be consistent with the theory that ventilation is determined by the elastic properties of lung tissue and 2. relationships between blood flow and blood volume (transit times) were investigated. We conclude that blood volume plays a significant role in the matching of ventilation and perfusion and that blood flow is fairly well matched by blood volumes, thus reducing the gravitational impact on capillary transit time and hematocrit ratio which might be of rheological importance. (au).

  12. Topography of pulmonary structure and function in man using positron emission tomography (PET) with special reference to methodology and normal physiology

    Energy Technology Data Exchange (ETDEWEB)

    Brundin, L.H. (MRC, Cyclotron Unit and Dept. of Medicine, Hammersmith Hospital, London (United Kingdom) and Lund Univ. (Sweden). Dept. of Clinical Physiology)

    1992-01-01

    Positron emission tomography (PET) allows regional quantification of specific tracer compounds to be made within a tomographic slice of the body. The present thesis which is methodological and descriptive, centers on in vivo measurements of regional lung compartments (gas, red cells, plasma and extravascular tissue) and ventilation and blood flow in normal subjects. A method of measuring regional lung hematocrit (rH) was developed and rH was found to be found to be 90% of the peripheral hematocrit in normal subjects. No significant regional variations within the lung fields were found in normal subjects or in patients with anemia or pneumonia, which enables the pulmonary whole blood volume to be regionally quantified using a single vascular tracer. This allowed a deeper examination of the interrelationship between the different lung compartments and their variation in the gravity dependent axis and during hyperinflation. Smokers were found to have higher extravascular density than non-smokers. By combining measurement of ventilation and [sup .]V[sub A]/[sup .]Q, methods were developed to 1. correct the measured [sup .]V[sub A]/[sup .]Q for incomplete equilibrium of [sup 13]N within the alveolar space. 2. calculate regional pulmonary perfusion. By further combining these measurements with measurements of vascular and extravascular lung volumes 1. relationship between ventilation and vascular and extravascular volumes were explored and found to be consistent with the theory that ventilation is determined by the elastic properties of lung tissue and 2. relationships between blood flow and blood volume (transit times) were investigated. We conclude that blood volume plays a significant role in the matching of ventilation and perfusion and that blood flow is fairly well matched by blood volumes, thus reducing the gravitational impact on capillary transit time and hematocrit ratio which might be of rheological importance. (au).

  13. PET/TAC in Oncology; PET/TAC en Oncologia

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez V, A.M. [Especialista en Medicina Nuclear, Profa. Depto. Radiologia de la Facultad de Medicina, Universidad Complutense de Madrid, Madrid (Spain)

    2007-07-01

    From this presentation of PET-TAC in oncology the following advantages on the conventional PET are obtained: 1. More short study and stadium in one session. 2. It adds the information of both techniques. 3. Better localization of leisure: affected organ, stadium change (neck, mediastinum, abdomen). 4. Reduction of false positive (muscle, brown fat, atelectasis, pneumonias, intestine, urinary vials, etc.). 5. Reduction of negative false. 6. Reduction of not conclusive. 7. More understandable for other specialists. 8. Biopsies guide. 9. Planning radiotherapy.

  14. Adhesion of nitrile rubber to UV-assisted surface chemical modified PET fabric, part II: Interfacial characterization of MDI grafted PET

    Science.gov (United States)

    Razavizadeh, Mahmoud; Jamshidi, Masoud

    2016-08-01

    Fiber to rubber adhesion is an important subject in rubber industry. It is well known that surface treatment (i.e. physical, mechanical and chemical) is an effective method to improve interfacial bonding of fibers and/or fabrics to rubbers. UV irradiation is an effective method which has been used to increase fabric-rubber interfacial interactions. In this research UV assisted chemical modification of PET fabrics was used to increase PET to nitrile rubber (NBR) adhesion. Nitrile rubber is a perfect selection as fuel and oil resistant rubber. However it has weak bonding to PET fabric. For this purpose PET fabric was carboxylated under UV irradiation and then methylenediphenyl diisocyanate (MDI) was grafted on carboxylated PET. The chemical composition of the fabric before and after surface treatment was investigated by X-ray photoelectron spectroscopy (XPS). The sectional morphology of the experimental PET fibers and the interface between rubber compound and PET fabric was studied using scanning electron microscope (SEM). The morphology and structure of the product were analyzed by an energy dispersive X-ray spectrometer (EDX). FTIR-ATR and H NMR analysis were used to assess surface modifications on the PET irradiated fabrics.

  15. 10 "Poison Pills" for Pets

    Science.gov (United States)

    ... Care Animal Welfare Veterinary Careers Public Health 10 "Poison Pills" for Pets Anyone who takes medication prescribed ... of all phone calls to the ASPCA Animal Poison Control Center (APCC) are about human medications. Your ...

  16. Take Care with Pet Reptiles

    Science.gov (United States)

    ... Past Emails CDC Features Take Care with Pet Reptiles and Amphibians Language: English Español (Spanish) Recommend on ... messages, and helpful resources. Safe Handling Tips for Reptiles and Amphibians Always wash your hands thoroughly after ...

  17. PET and PET/CT in tumour of undetermined origin; PET y PET/CT en tumor de origen indeterminado

    Energy Technology Data Exchange (ETDEWEB)

    Garcia O, J.R. [Nuclear Medicine and Molecular Imaging, PET/CT, Centro Medico ABC, Mexico D.F. (Mexico)

    2007-07-01

    In this presentation the following conclusions were obtained regarding the use of PET and PET/CT in patient with cancer of unknown primary: 1. Detection of the primary one in 1/3 at 1/2 of patient. 2. It detects metastases in other places in 50%. 3. It changes the initial therapy planned in 1/3 at 1/2 of patient. 4. Useful in initial phases of protocol study to limit the other procedures. After standard evaluation. Before advanced protocol. 5. PET/CT study increases the % of primary detection, although in a non significant way vs. PET. 6. They are required more studies to value their utility to a more objective manner. (Author)

  18. Nutritional sustainability of pet foods.

    Science.gov (United States)

    Swanson, Kelly S; Carter, Rebecca A; Yount, Tracy P; Aretz, Jan; Buff, Preston R

    2013-03-01

    Sustainable practices meet the needs of the present without compromising the ability of future generations to meet their needs. Applying these concepts to food and feed production, nutritional sustainability is the ability of a food system to provide sufficient energy and essential nutrients required to maintain good health in a population without compromising the ability of future generations to meet their nutritional needs. Ecological, social, and economic aspects must be balanced to support the sustainability of the overall food system. The nutritional sustainability of a food system can be influenced by several factors, including the ingredient selection, nutrient composition, digestibility, and consumption rates of a diet. Carbon and water footprints vary greatly among plant- and animal-based ingredients, production strategy, and geographical location. Because the pet food industry is based largely on by-products and is tightly interlinked with livestock production and the human food system, however, it is quite unique with regard to sustainability. Often based on consumer demand rather than nutritional requirements, many commercial pet foods are formulated to provide nutrients in excess of current minimum recommendations, use ingredients that compete directly with the human food system, or are overconsumed by pets, resulting in food wastage and obesity. Pet food professionals have the opportunity to address these challenges and influence the sustainability of pet ownership through product design, manufacturing processes, public education, and policy change. A coordinated effort across the industry that includes ingredient buyers, formulators, and nutritionists may result in a more sustainable pet food system.

  19. Are Pets in the Bedroom a Problem?

    Science.gov (United States)

    Krahn, Lois E; Tovar, M Diane; Miller, Bernie

    2015-12-01

    The presence of pets in the bedroom can alter the sleep environment in ways that could affect sleep. Data were collected by questionnaire and interview from 150 consecutive patients seen at the Center for Sleep Medicine, Mayo Clinic in Arizona. Seventy-four people (49%) reported having pets, with 31 (41% of pet owners) having multiple pets. More than half of pet owners (56%) allowed their pets to sleep in the bedroom. Fifteen pet owners (20%) described their pets as disruptive, whereas 31 (41%) perceived their pets as unobtrusive or even beneficial to sleep. Health care professionals working with patients with sleep concerns should inquire about the presence of companion animals in the sleep environment to help them find solutions and optimize their sleep.

  20. Advances in Clinical PET/MRI Instrumentation.

    Science.gov (United States)

    Herzog, Hans; Lerche, Christoph

    2016-04-01

    In 2010, the first whole-body PET/MRI scanners installed for clinical use were the sequential Philips PET/MRI with PMT-based, TOF-capable technology and the integrated simultaneous Siemens PET/MRI. Avalanche photodiodes as non-magneto-sensitive readout electronics allowed PET integrated within the MRI. The experiences with these scanners showed that improvements of software aspects, such as attenuation correction, were necessary and that efficient protocols combining optimally PET and MRI must be still developed. In 2014, General Electric issued an integrated PET/MRI with SiPM-based PET detectors, allowing TOF-PET. Looking at the MRI components of current PET/MR imaging systems, primary improvements come from sequences and new coils.

  1. Do carotid MR surface coils affect PET quantification in PET/MR imaging?

    Energy Technology Data Exchange (ETDEWEB)

    Willemink, Martin J; Eldib, Mootaz [Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY (United States); Leiner, Tim [Department of Radiology, University Medical Center Utrecht, Utrecht (Netherlands); Fayad, Zahi A; Mani, Venkatesh [Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY (United States)

    2015-05-18

    To evaluate the effect of surface coils for carotid MR imaging on PET quantification in a clinical simultaneous whole-body PET/MR scanner. A cylindrical phantom was filled with a homogeneous 2L water-FDG mixture at a starting dose of 301.2MBq. Clinical PET/MR and PET/CT systems were used to acquire PET-data without a coil (reference standard) and with two carotid MRI coils (Siemens Special Purpose 8-Channel and Machnet 4-Channel Phased Array). PET-signal attenuation was evaluated with Osirix using 51 (PET/MR) and 37 (PET/CT) circular ROIs. Mean and maximum standardized uptake values (SUVs) were quantified for each ROI. Furthermore, SUVs of PET/MR and PET/CT were compared. For validation, a patient was scanned with an injected dose of 407.7MBq on both a PET/CT and a PET/MR system without a coil and with both coils. PET/MR underestimations were -2.2% (Siemens) and -7.8% (Machnet) for SUVmean, and -1.2% (Siemens) and -3.3% (Machnet) for SUVmax, respectively. For PET/CT, underestimations were -1.3% (Siemens) and -1.4% (Machnet) for SUVmean and -0.5% (both Siemens and Machnet) for SUVmax, respectively using no coil data as reference. Except for PET/CT SUVmax values all differences were significant. SUVs differed significantly between PET/MR and PET/CT with SUVmean values of 0.51-0.55 for PET/MR and 0.68-0.69 for PET/CT, respectively. The patient examination showed that median SUVmean values measured in the carotid arteries decreased from 0.97 without a coil to 0.96 (Siemens) and 0.88 (Machnet). Carotid surface coils do affect attenuation correction in both PET/MR and PET/CT imaging. Furthermore, SUVs differed significantly between PET/MR and PET/CT.

  2. PET/CT and radiotherapy in prostate cancer.

    Science.gov (United States)

    De Jong, I J; De Haan, T D; Wiegman, E M; Van Den Bergh, A C M; Pruim, J; Breeuwsma, A J

    2010-10-01

    Radiotherapy is one of the corner stone treatments for patients with prostate cancer. Especially for locally advanced tumors radiotherapy +/- adjuvant androgen deprivation treatment is standard of care. This brings up the need for accurate assessment of extra prostatic tumor growth and/or the presence of nodal metastases for selection of the optimal radiation dose and treatment volume. Morphological imaging like transrectal ultra sound, computed tomography (CT) and magnetic resonance imaging (MRI) are routinely used but are limited in their accuracy in detecting extra prostatic extension and nodal metastases. In this article we present a structured review of the literature on positron emission tomography (PET)/CT and radiotherapy in prostate cancer patients with emphasis on: 1) the pretreatment assessment of extra prostatic tumor extension, nodal and distant metastases; 2) the intraprostatic tumor characterization and radiotherapy treatment planning; and 3) treatment evaluation and the use of PET/CT in guidance of salvage treatment. PET/CT is not an appropriate imaging technique for accurate T-staging of prostate cancer prior to radiotherapy. Although macroscopic disease beyond the prostatic capsule and into the periprostatic fat or in seminal vesicle is often accurately detected, the microscopic extension of prostate cancer remains undetected. Choline PET/CT holds a great potential as a single step diagnostic procedure of lymph nodes and skeleton, which could facilitate radiotherapy treatment planning. At present the use of PET/CT for treatment planning in radiotherapy is still experimental. Choline PET based tumor delineation is not yet standardized and different segmentation-algorithms are under study. However, dose escalation using dose-painting is feasible with only limited increases of the doses to the bladder and rectum wall. PET/CT using either acetate or choline is able to detect recurrent prostate cancer after radiotherapy but stratification of patients

  3. Chemical recycling of post-consumer PET: structural characterization of terephthalic acid and the effect of Alkaline Hydrolysis at low temperature; Reciclagem quimica do PET pos-consumo: caracterizacao estrutural do acido tereftalico e efeito da hidrolise alcalina em baixa temperatura

    Energy Technology Data Exchange (ETDEWEB)

    Fonseca, Talitha Granja; Almeida, Yeda Medeiros Bastos de; Vinhas, Gloria Maria, E-mail: gmvinhas@yahoo.com.br [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Dept. de Engenharia Quimica

    2014-09-15

    Due to the environmental impact caused by PET packaging disposal, this material recycling has been thoroughly discussed and evaluated. In particular, chemical recycling enables achievement of the monomers that are used in PET resin manufacture: ethylene glycol (EG) and terephthalic acid (PTA). Therefore, studies for this process optimization are important from environmental and economic points of view. The present study investigated certain parameters that influence the depolymerization reaction of PET post-consumer via alkaline hydrolysis in order to obtain PTA. Assays were performed at 70 °C by varying the concentration of sodium hydroxide and the reaction time. The best results were obtained at 10.82 mol L{sup -1} NaOH and 9 h reaction time. Consequently, it was possible to prove this process viability, once analyses by infrared and nuclear magnetic resonance confirmed that PTA was obtained in all reactions performed. (author)

  4. Parasites, pets, and people.

    Science.gov (United States)

    Marx, M B

    1991-03-01

    It is important for the family physician to understand that patients' relationships with their pets play an important role in helping maintain mental and physical health yet provide the potential for causing illness in the patient. Toxocara canis (dog roundworm) and Toxocara cati (cat roundworm) are the ascarids most commonly responsible for VLM and ocular larva migrans in humans. These roundworms live in their adult stage in the small intestine of the dog and cat where their eggs are passed in the feces. The eggs containing the infective larva are very sticky, thus an infant crawling around on the floor can easily pick these up on fingers that almost invariably end up in the mouth. Infections are usually mild and asymptomatic but with a persistent eosinophilia. Ocular larva migrans is the form usually occurring in older children and adults. Some public health veterinarians recommend that a puppy or kitten should not be obtained as a companion for a child who is not old enough to read, thus bypassing the crawling and toddler stages. Hookworm eggs, shed in the feces of infected dogs or cats, develop into the infective second stage within a week. Humans are usually infected when bare areas of skin such as bare feet or the torso come in contact with soil contaminated with the larvae. The second-stage larvae are able to penetrate the intact skin of humans and the foot pads of dogs and cats. In the United States, the common dog hookworm, A. caninum, is a widespread parasite. Human intestinal ancylostomiasis caused by this species is rare, with only six cases recorded in the literature. Infection in humans or animals by the common tapeworm of dogs and cats (Dipylidium caninum) requires ingestion of the intermediate host, the dog or cat flea containing the larva (cysticercoids) of the agent. Many cases in humans are asymptomatic. Dipylidiasis affects mainly infants and young children who may swallow a flea that hops up while the infant is crawling on the floor or fondling

  5. Lung tumor segmentation in PET images using graph cuts.

    Science.gov (United States)

    Ballangan, Cherry; Wang, Xiuying; Fulham, Michael; Eberl, Stefan; Feng, David Dagan

    2013-03-01

    The aim of segmentation of tumor regions in positron emission tomography (PET) is to provide more accurate measurements of tumor size and extension into adjacent structures, than is possible with visual assessment alone and hence improve patient management decisions. We propose a segmentation energy function for the graph cuts technique to improve lung tumor segmentation with PET. Our segmentation energy is based on an analysis of the tumor voxels in PET images combined with a standardized uptake value (SUV) cost function and a monotonic downhill SUV feature. The monotonic downhill feature avoids segmentation leakage into surrounding tissues with similar or higher PET tracer uptake than the tumor and the SUV cost function improves the boundary definition and also addresses situations where the lung tumor is heterogeneous. We evaluated the method in 42 clinical PET volumes from patients with non-small cell lung cancer (NSCLC). Our method improves segmentation and performs better than region growing approaches, the watershed technique, fuzzy-c-means, region-based active contour and tumor customized downhill.

  6. Simultaneous MRI and PET imaging of a rat brain

    Science.gov (United States)

    Raylman, Raymond R.; Majewski, Stan; Lemieux, Susan K.; Sendhil Velan, S.; Kross, Brian; Popov, Vladimir; Smith, Mark F.; Weisenberger, Andrew G.; Zorn, Carl; Marano, Gary D.

    2006-12-01

    Multi-modality imaging is rapidly becoming a valuable tool in the diagnosis of disease and in the development of new drugs. Functional images produced with PET fused with anatomical structure images created by MRI will allow the correlation of form with function. Our group is developing a system to acquire MRI and PET images contemporaneously. The prototype device consists of two opposed detector heads, operating in coincidence mode. Each MRI-PET detector module consists of an array of LSO detector elements coupled through a long fibre optic light guide to a single Hamamatsu flat panel position-sensitive photomultiplier tube (PSPMT). The use of light guides allows the PSPMTs to be positioned outside the bore of a 3T MRI scanner where the magnetic field is relatively small. To test the device, simultaneous MRI and PET images of the brain of a male Sprague Dawley rat injected with FDG were successfully obtained. The images revealed no noticeable artefacts in either image set. Future work includes the construction of a full ring PET scanner, improved light guides and construction of a specialized MRI coil to permit higher quality MRI imaging.

  7. Simultaneous MRI and PET imaging of a rat brain

    Energy Technology Data Exchange (ETDEWEB)

    Raylman, Raymond R [Center for Advanced Imaging, Department of Radiology, Box 9236, West Virginia University, Morgantown, WV (United States); Majewski, Stan [Thomas Jefferson National Accelerator Facility, 12000 Jefferson Ave., Newport News, VA (United States); Lemieux, Susan K [Center for Advanced Imaging, Department of Radiology, Box 9236, West Virginia University, Morgantown, WV (United States); Velan, S Sendhil [Center for Advanced Imaging, Department of Radiology, Box 9236, West Virginia University, Morgantown, WV (United States); Kross, Brian [Thomas Jefferson National Accelerator Facility, 12000 Jefferson Ave., Newport News, VA (United States); Popov, Vladimir [Thomas Jefferson National Accelerator Facility, 12000 Jefferson Ave., Newport News, VA (United States); Smith, Mark F [Thomas Jefferson National Accelerator Facility, 12000 Jefferson Ave., Newport News, VA (United States); Weisenberger, Andrew G [Thomas Jefferson National Accelerator Facility, 12000 Jefferson Ave., Newport News, VA (United States); Zorn, Carl [Thomas Jefferson National Accelerator Facility, 12000 Jefferson Ave., Newport News, VA (United States); Marano, Gary D [Center for Advanced Imaging, Department of Radiology, Box 9236, West Virginia University, Morgantown, WV (United States)

    2006-12-21

    Multi-modality imaging is rapidly becoming a valuable tool in the diagnosis of disease and in the development of new drugs. Functional images produced with PET fused with anatomical structure images created by MRI will allow the correlation of form with function. Our group is developing a system to acquire MRI and PET images contemporaneously. The prototype device consists of two opposed detector heads, operating in coincidence mode. Each MRI-PET detector module consists of an array of LSO detector elements coupled through a long fibre optic light guide to a single Hamamatsu flat panel position-sensitive photomultiplier tube (PSPMT). The use of light guides allows the PSPMTs to be positioned outside the bore of a 3T MRI scanner where the magnetic field is relatively small. To test the device, simultaneous MRI and PET images of the brain of a male Sprague Dawley rat injected with FDG were successfully obtained. The images revealed no noticeable artefacts in either image set. Future work includes the construction of a full ring PET scanner, improved light guides and construction of a specialized MRI coil to permit higher quality MRI imaging.

  8. Sensitivity of CLIC at 380 GeV to the top FCNC decay $t\\rightarrow cH$

    CERN Document Server

    AUTHOR|(SzGeCERN)442572

    2017-01-01

    In the Standard Model (SM), flavour changing neutral current (FCNC) top decays, possible at loop level only, are very strongly suppressed. Observation of any such decay would be a direct signature of physics beyond the SM. Large enhancements are possible in many "new physics" scenarios and the largest enhancement is in most cases expected for the $t\\rightarrow cH$ decay. A full study for CLIC was based on the WHIZARD simulation of FCNC top decays within the 2HDM(III) model. Beam polarization and beam-induced background were taken into account. Top pair production events with the FCNC decay $t\\rightarrow cH$ can be identified based on kinematic constrains and flavour tagging information. Due to a large overlap in the kinematic space with standard top pair events, the final signal selection-efficiency is small, at the 10% level. Expected limits on $BR(t\\rightarrow cH)\\times BR(H\\rightarrow b\\bar{b})$ are compared with earlier results based on parton level simulation.

  9. Photon backgrounds at the CLIC interaction point due to losses in the post-collision extraction line

    CERN Document Server

    Salt, M D; Elsener, K; Ferrari, A

    2010-01-01

    The CLIC beam delivery system focuses 1.5~TeV electron and positron beams to a nanometre-sized cross section when colliding them at the interaction point (IP). The intense focusing leads to large beam-beam effects, causing the production of beamstrahlung photons, coherent and incoherent $e^+e^-$ pairs, as well as a significant disruption of the main beam. The transport of the post-collision beams requires a minimal loss extraction line, with high acceptance for energy deviation and divergence. The current design includes vertical bends close to the IP in order to separate the charged particles with a sign opposite to the main beam into a diagnostic-equipped intermediate dump, whilst transporting the photons and the main beam to the final dump. Photon and charged particle losses on magnet masks and dumps result in a complex radiation field and IP background particle fluxes. In this paper, the electromagnetic backgrounds at the IP arising from the losses occurring closest to the collision point are calculated.

  10. Study of the electronics architecture for the mechanical stabilisation of the quadrupoles of the CLIC linear accelerator

    Science.gov (United States)

    Artoos, K.; Collette, C.; Fernandez Carmona, P.; Guinchard, M.; Hauviller, C.; Janssens, S.; Kuzmin, A.; Slaathaug, A.

    2010-11-01

    To reach a sufficient luminosity, the transverse beam sizes and emittances in future linear particle accelerators should be reduced to the nanometer level. Mechanical stabilisation of the quadrupole magnets is of the utmost importance for this. The piezo actuators used for this purpose can also be used to make fast incremental orientation adjustments with a nanometer resolution. The main requirements for the CLIC stabilisation electronics is a robust, low noise, low delay, high accuracy and resolution, low band and radiation resistant feedback control loop. Due to the high number of controllers (about 4000) a cost optimization should also be made. Different architectures are evaluated for a magnet stabilisation prototype, including the sensors type and configuration, partition between software and hardware for control algorithms, and optimization of the ADC/DAC converters. The controllers will be distributed along the 50 km long accelerator and a communication bus should allow external control. Furthermore, one might allow for an adaptive method to increase the S/N ratio of vibration measurements by combining seismometer measurements of adjacent magnets. Finally a list of open topics, the current limitations and the plans to overcome them will be presented.

  11. A Study of e+e− → H0A0 → bbbb at 3 TeV at CLIC

    CERN Document Server

    Battaglia, M

    2010-01-01

    The precise determination of the masses of the CP-odd and -even heavy Higgs bosons is an important part of the study of Supersymmetry and its relation with cosmology through dark matter. This note presents a determination of the A0 mass with the e+e− → H0A0 → bb ̄bb ̄ process for a dark matter motivated cMSSM scenario with MA = 1141 GeV at CLIC. The analysis is performed with full simulation and reconstruction at √s=3 TeV accounting for beamstrahlung effects. SM and SUSY backgrounds are considered and the effect of the overlay of γγ → hadrons events on the signal is studied for various assumptions for the detector time-stamping capabilities. The di-jet mass resolution is improved by applying a kinematic fit. The A0 mass can be determined with a statistical accuracy of ≃ 3-5 GeV for 3 ab−1 of integrated luminosity and 0 to 20 bunch crossings of γγ background integrated in one event, respectively.

  12. High-voltage pixel detectors in commercial CMOS technologies for ATLAS, CLIC and Mu3e experiments

    CERN Document Server

    Peric, Ivan; Backhaus, Malte; Barbero, Marlon; Benoit, Mathieu; Berger, Niklaus; Bompard, Frederic; Breugnon, Patrick; Clemens, Jean-Claude; Dannheim, Dominik; Dierlamm, Alexander; Feigl, Simon; Fischer, Peter; Fougeron, Denis; Garcia-Sciveres, Maurice; Heim, Timon; Hügging, Fabian; Kiehn, Moritz; Kreidl, Christian; Krüger, Hans; La Rosa, Alessandro; Liu, Jian; Lütticke, Florian; Mariñas, Carlos; Meng, Lingxin; Miucci, Antonio; Münstermann, Daniel; Nguyen, Hong Hanh; Obermann, Theresa; Pangaud, Patrick; Perrevoort, Ann-Kathrin; Rozanov, Alexandre; Schöning, André; Schwenker, Benjamin; Wiedner, Dirk

    2013-01-01

    High-voltage particle detectors in commercial CMOS technologies are a detector family that allows implementation of low-cost, thin and radiation-tolerant detectors with a high time resolution. In the R/D phase of the development, a radiation tolerance of 10 15 n eq = cm 2 , nearly 100% detection ef fi ciency and a spatial resolution of about 3 μ m were demonstrated. Since 2011 the HV detectors have fi rst applications: the technology is presently the main option for the pixel detector of the planned Mu3e experiment at PSI (Switzerland). Several prototype sensors have been designed in a standard 180 nm HV CMOS process and successfully tested. Thanks to its high radiation tolerance, the HV detectors are also seen at CERN as a promising alternative to the standard options for ATLAS upgrade and CLIC. In order to test the concept, within ATLAS upgrade R/D, we are currently exploring an active pixel detector demonstrator HV2FEI4; also implemented in the 180 nm HV process

  13. Radiation and Background Levels in a CLIC Detector due to Beam-Beam Effects Optimisation of Detector Geometries and Technologies

    CERN Document Server

    Sailer, André; Lohse, Thomas

    2013-01-10

    The high charge density---due to small beam sizes---and the high energy of the proposed CLIC concept for a linear electron--positron collider with a centre-of-mass energy of up to 3~TeV lead to the production of a large number of particles through beam-beam interactions at the interaction point during every bunch crossing (BX). A large fraction of these particles safely leaves the detector. A still significant amount of energy will be deposited in the forward region nonetheless, which will produce secondary particles able to cause background in the detector. Furthermore, some particles will be created with large polar angles and directly cause background in the tracking detectors and calorimeters. The main sources of background in the detector, either directly or indirectly, are the incoherent $mathrm{e}^{+}mathrm{e}^{-}$ pairs and the particles from $gammagamma ightarrow$ hadron events. The background and radiation levels in the detector have to be estimated, to study if a detector is feasible, that can han...

  14. High-voltage pixel detectors in commercial CMOS technologies for ATLAS, CLIC and Mu3e experiments

    CERN Document Server

    Peric,I et al.

    2013-01-01

    High-voltage particle detectors in commercial CMOS technologies are a detector family that allows implementation of low-cost, thin and radiation-tolerant detectors with a high time resolution. In the R/D phase of the development, a radiation tolerance of 1015 neq=cm2 , nearly 100% detection efficiency and a spatial resolution of about 3 μm were demonstrated. Since 2011 the HV detectors have first applications: the technology is presently the main option for the pixel detector of the planned Mu3e experiment at PSI (Switzerland). Several prototype sensors have been designed in a standard 180 nm HV CMOS process and successfully tested. Thanks to its high radiation tolerance, the HV detectors are also seen at CERN as a promising alternative to the standard options for ATLAS upgrade and CLIC. In order to test the concept, within ATLAS upgrade R/D, we are currently exploring an active pixel detector demonstrator HV2FEI4; also implemented in the 180 nm HV process.

  15. Neutral Higgs Boson Pair-Production and Trilinear Self-Couplings in the MSSM at ILC and CLIC Energies

    CERN Document Server

    Gutiérrez-Rodríguez, A; Sampayo, O A

    2009-01-01

    We study pair-production as well as the triple self-couplings of the neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) at the Future International Linear $e^{+}e^{-}$ Collider (ILC) and Compact Linear Collider (CLIC). The analysis is based on the reactions $e^{+}e^{-}\\to b \\bar b h_ih_i, t \\bar t h_ih_i$ with $h_i=h, H, A$. We evaluate the total cross-section for both $b\\bar bh_ih_i$, $t\\bar th_ih_i$ and calculate the total number of events considering the complete set of Feynman diagrams at tree-level. We vary the triple couplings $\\kappa\\lambda_{hhh}$, $\\kappa\\lambda_{Hhh}$, $\\kappa\\lambda_{hAA}$, $\\kappa\\lambda_{HAA}$, $\\kappa\\lambda_{hHH}$ and $\\kappa\\lambda_{HHH}$ within the range $\\kappa=-1$ and +2. The numerical computation is done for the energies expected at the ILC with a center-of-mass energy 500, 1000, 1600 $GeV$ and a luminosity 1000 $fb^{-1}$. The channels $e^{+}e^{-}\\to b \\bar b h_ih_i$ and $e^{+}e^{-}\\to t \\bar t h_ih_i$ are also discussed to a center-of-mass energy of 3...

  16. New shielding configurations for a simultaneous PET/MRI scanner at 7T.

    Science.gov (United States)

    Peng, Bo J; Wu, Yibao; Cherry, Simon R; Walton, Jeffrey H

    2014-02-01

    Understanding sources of electromagnetic interference are important in designing any electronic system. This is especially true when combining positron emission tomography (PET) and magnetic resonance imaging (MRI) in a multimodality system as coupling between the subsystems can degrade the performance of either modality. For this reason, eliminating radio frequency (RF) interference and gradient-induced eddy currents have been major challenges in building simultaneous hybrid PET/MRI systems. MRI requires negligible RF interference at the Larmor resonance frequency, while RF interference at almost any frequency may corrupt PET data. Moreover, any scheme that minimizes these interactions would, ideally, not compromise the performance of either subsystem. This paper lays out a plan to resolve these problems. A carbon fiber composite material is found to be a good RF shield at the Larmor frequency (300MHz in this work) while introducing negligible gradient eddy currents. This carbon fiber composite also provides excellent structural support for the PET detector components. Low frequency electromagnetic radiation (81kHz here) from the switching power supplies of the gradient amplifiers was also found to interfere with the PET detector. Placing the PET detector module between two carbon fiber tubes and grounding the inner carbon fiber tube to the PET detector module ground reduced this interference. Further reductions were achieved by adding thin copper (Cu) foil on the outer carbon fiber case and electrically grounding the PET detector module so that all 3 components had a common ground, i.e. with the PET detector in an electrostatic cage. Finally, gradient switching typical in MRI sequences can result in count losses in the particular PET detector design studied. Moreover, the magnitude of this effect depends on the location of the detector within the magnet bore and which MRI gradient is being switched. These findings have a bearing on future designs of PET

  17. PET-CT工作原理及应用%Principle and application of PET-CT

    Institute of Scientific and Technical Information of China (English)

    张秀文; 张永寿; 刘乃智

    2012-01-01

    Objective: PET-CT is to use to achieve image fusion of PET and CT in the same machine, is functional imaging equipment. With the rapid spread of its application, it goes beyond the existing areas of PET alone and separate CT for medical research and clinical diagnostics, it provides a great convenience. Methods: PET is deferent with CT in the imaging principle, the combination of these two equipment can get the image of anatomical structure, abundant physiological and biochemical functions. It can provide the quantitative, qualitative diagnostic basis for the identify and locate the precise location of tumors. Results: PET-CT fusion images can be used to describe the role of disease on the biochemical processes, identify physiological and pathological uptake. It can detect the early onset of signs of disease anatomical evidence and even very small subclinical tumor correctly. It has an important value in determining the clinical radiotherapy planning target volume, the detection process of treatment drugs and radiation effects to provide the best treatment options to improve the clinical cure rate. Conclusion: The work is in good condition or not determines by the maintenance. Firstly we should clear the equipment requirements of the environment in the process of routine maintenance carefully. Maintain equipment environment requires qualified engineering and technical personnel familiar with every aspect of the usually diligent maintenance, did not miss any possible hazards to more good to ensure that the operation of the equipment.%目的:PET-CT实现了同机图像融合,是一种功能性医学影像学设备,通过了解其工作原理,掌握设备的日常维护方法,为医学研究和临床诊断提供便利.方法:分别介绍PET与CT两种设备同机组合的不同成像原理以及设备应用时对环境的要求.结果:了解PET-CT的工作原理,掌握一般维护保养项目和方法,使PET-CT融合影像为临床正确确定放疗的计划靶区、

  18. Quantitative PET imaging with the 3T MR-BrainPET

    Energy Technology Data Exchange (ETDEWEB)

    Weirich, C., E-mail: c.weirich@fz-juelich.de [Forschungszentrum Jülich, Institute of Neuroscience and Medicine – 4, Juelich (Germany); Scheins, J.; Lohmann, P.; Tellmann, L. [Forschungszentrum Jülich, Institute of Neuroscience and Medicine – 4, Juelich (Germany); Byars, L.; Michel, C. [Siemens Healthcare, Molecular Imaging, Knoxville, TN (United States); Rota Kops, E.; Brenner, D.; Herzog, H.; Shah, N.J. [Forschungszentrum Jülich, Institute of Neuroscience and Medicine – 4, Juelich (Germany)

    2013-02-21

    The new hybrid imaging technology of MR-PET allows for simultaneous acquisition of versatile MRI contrasts and the quantitative metabolic imaging with PET. In order to achieve the quantification of PET images with minimal residual error the application of several corrections is crucial. In this work we present our results on quantification with the 3T MR BrainPET scanner.

  19. Exercises in PET Image Reconstruction

    Science.gov (United States)

    Nix, Oliver

    These exercises are complementary to the theoretical lectures about positron emission tomography (PET) image reconstruction. They aim at providing some hands on experience in PET image reconstruction and focus on demonstrating the different data preprocessing steps and reconstruction algorithms needed to obtain high quality PET images. Normalisation, geometric-, attenuation- and scatter correction are introduced. To explain the necessity of those some basics about PET scanner hardware, data acquisition and organisation are reviewed. During the course the students use a software application based on the STIR (software for tomographic image reconstruction) library 1,2 which allows them to dynamically select or deselect corrections and reconstruction methods as well as to modify their most important parameters. Following the guided tutorial, the students get an impression on the effect the individual data precorrections have on image quality and what happens if they are forgotten. Several data sets in sinogram format are provided, such as line source data, Jaszczak phantom data sets with high and low statistics and NEMA whole body phantom data. The two most frequently used reconstruction algorithms in PET image reconstruction, filtered back projection (FBP) and the iterative OSEM (ordered subset expectation maximation) approach are used to reconstruct images. The exercise should help the students gaining an understanding what the reasons for inferior image quality and artefacts are and how to improve quality by a clever choice of reconstruction parameters.

  20. Specific recommendations for accurate and direct use of PET-CT in PET guided radiotherapy for head and neck sites

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, C. M., E-mail: christopher.thomas@gstt.nhs.uk; Convery, D. J.; Greener, A. G. [Guy' s and St. Thomas’ NHS Foundation Trust, Medical Physics Department, St. Thomas’ Hospital, London SE1 7EH (United Kingdom); Pike, L. C.; Baker, S.; Woods, E. [Division of Imaging Sciences and Biomedical Engineering, King' s College London, King' s Health Partners, St. Thomas’ Hospital, London SE1 7EH (United Kingdom); Hartill, C. E. [Guy' s and St. Thomas’ NHS Foundation Trust, Radiotherapy, Clinical Outpatients Clinic, St. Thomas’ Hospital, London SE1 7EH (United Kingdom)

    2014-04-15

    Purpose: To provide specific experience-based guidance and recommendations for centers wishing to develop, validate, and implement an accurate and efficient process for directly using positron emission tomography-computed tomography (PET-CT) for the radiotherapy planning of head and neck cancer patients. Methods: A PET-CT system was modified with hard-top couch, external lasers and radiotherapy immobilization and indexing devices and was subject to a commissioning and quality assurance program. PET-CT imaging protocols were developed specifically for radiotherapy planning and the image quality and pathway tested using phantoms and five patients recruited into an in-house study. Security and accuracy of data transfer was tested throughout the whole data pathway. The patient pathway was fully established and tested ready for implementation in a PET-guided dose-escalation trial for head and neck cancer patients. Results: Couch deflection was greater than for departmental CT simulator machines. An area of high attenuation in the couch generated image artifacts and adjustments were made accordingly. Using newly developed protocols CT image quality was suitable to maintain delineation and treatment accuracy. Upon transfer of data to the treatment planning system a half pixel offset between PET and CT was observed and corrected. By taking this into account, PET to CT alignment accuracy was maintained below 1 mm in all systems in the data pathway. Transfer of structures delineated in the PET fusion software to the radiotherapy treatment planning system was validated. Conclusions: A method to perform direct PET-guided radiotherapy planning was successfully validated and specific recommendations were developed to assist other centers. Of major concern is ensuring that the quality of PET and CT data is appropriate for radiotherapy treatment planning and on-treatment verification. Couch movements can be compromised, bore-size can be a limitation for certain immobilization

  1. Pet Meds Sending Kids to the ER

    Science.gov (United States)

    ... Health and Human Services. More Health News on: Child Safety Pet Health Poisoning Recent Health News Related MedlinePlus Health Topics Child Safety Pet Health Poisoning About MedlinePlus Site Map FAQs Customer ...

  2. PET/MRI in cancer patients

    DEFF Research Database (Denmark)

    Kjær, Andreas; Loft, Annika; Law, Ian;

    2013-01-01

    Combined PET/MRI systems are now commercially available and are expected to change the medical imaging field by providing combined anato-metabolic image information. We believe this will be of particular relevance in imaging of cancer patients. At the Department of Clinical Physiology, Nuclear...... Medicine & PET at Rigshospitalet in Copenhagen we installed an integrated PET/MRI in December 2011. Here, we describe our first clinical PET/MR cases and discuss some of the areas within oncology where we envision promising future application of integrated PET/MR imaging in clinical routine. Cases...... described include brain tumors, pediatric oncology as well as lung, abdominal and pelvic cancer. In general the cases show that PET/MRI performs well in all these types of cancer when compared to PET/CT. However, future large-scale clinical studies are needed to establish when to use PET/MRI. We envision...

  3. PET for Staging of Esophageal Cancer

    Institute of Scientific and Technical Information of China (English)

    A.H.Hoelscher

    2004-01-01

    FDG-PET is of clinical value especially for detection of distant metastases or recurrent esophageal cancer. For the staging of primary tumor or locoregional lymph node metastasis PET is currently not suitable.

  4. Cost-effectiveness of PET and PET/Computed Tomography

    DEFF Research Database (Denmark)

    Gerke, Oke; Hermansson, Ronnie; Hess, Søren

    2015-01-01

    measure by means of incremental cost-effectiveness ratios when considering the replacement of the standard regimen by a new diagnostic procedure. This article discusses economic assessments of PET and PET/computed tomography reported until mid-July 2014. Forty-seven studies on cancer and noncancer......The development of clinical diagnostic procedures comprises early-phase and late-phase studies to elucidate diagnostic accuracy and patient outcome. Economic assessments of new diagnostic procedures compared with established work-ups indicate additional cost for 1 additional unit of effectiveness...

  5. Diagnostic value of 18F-FDG PET and 11C-PIB PET on early stage posterior cortical atrophy

    Directory of Open Access Journals (Sweden)

    Shuai LIU

    2015-08-01

    Full Text Available Background  Posterior cortical atrophy (PCA is a kind of progressive neurodegenerative disease with cortical visual impairment as the first symptom. Because of rare clinical incidence, early onset age, special clinical symptoms and unobvious MRI abnormality, the definitive diagnosis of PCA is difficult. This study used 18F-fluoro-2-deoxy-D-glucose (18F-FDG PET and 11C-Pittsburgh compound B (11C-PIB PET for PCA patients with unobvious MRI abnormality, so as to discuss the value of PET in the early diagnosis of PCA.  Methods  Five patients diagnosed as PCA in our hospital between April 2012 and March 2015 were enrolled in this study. Cognitive function was measured by Mini-Mental State Examination (MMSE, Montreal Cognitive Assessment (MoCA, Activities of Daily Living (ADL and Clock Drawing Test (CDT. Brain MRI, 18F-FDG PET and 11C-PIB PET were performed to analyze glucose metabolism and perfusion of posterior cortex.  Results Neuropsychological tests revealed that the ability of writing, calculating, visuospatial and executive function of all these patients were impaired. Color vision tests showed abnormal results. MRI showed that the posterior atrophy (PA scores were 0-2 (average 1 on the left side and 0-1 (average 0.80 on the right side. The medial temporal atrophy (MTA scores were 1-3 (average 1.80 on the left side and 1-4 (average 2 on the right side. The ventricular enlargement (VE scores were 1-2 (average 1.80 on the left side and 1-2 (average 1.60 on the right side. 18F-FDG PET showed glucose metabolism decreased obviously on bilateral temporo-parieto-occipital cortex, precuneus and cingulate gyrus, and slightly on frontal lobes and subcortical structure. 11C-PIB PET showed radioactive 11C-PIB deposition on bilateral frontal, temporal, parietal and occipital cortex, and the outline of cerebellar cortex was clear.  Conclusions  For PCA patients whose parietal and occipital cortical atrophy is not obvious on MRI, 18F-FDG PET

  6. PET and SPECT in neurology

    Energy Technology Data Exchange (ETDEWEB)

    Dierckx, Rudi A.J.O. [Groningen University Medical Center (Netherlands). Dept. of Nuclear Medicine and Molecular Imaging; Ghent Univ. (Belgium). Dept. of Radiology and Nuclear Medicine; Vries, Erik F.J. de; Waarde, Aren van [Groningen University Medical Center (Netherlands). Dept. of Nuclear Medicine and Molecular Imaging; Otte, Andreas (ed.) [Univ. of Applied Sciences Offenburg (Germany). Faculty of Electrical Engineering and Information Technology

    2014-07-01

    PET and SPECT in Neurology highlights the combined expertise of renowned authors whose dedication to the investigation of neurological disorders through nuclear medicine technology has achieved international recognition. Classical neurodegenerative disorders are discussed as well as cerebrovascular disorders, brain tumors, epilepsy, head trauma, coma, sleeping disorders, and inflammatory and infectious diseases of the CNS. The latest results in nuclear brain imaging are detailed. Most chapters are written jointly by a clinical neurologist and a nuclear medicine specialist to ensure a multidisciplinary approach. This state-of-the-art compendium will be valuable to anybody in the field of neuroscience, from the neurologist and the radiologist/nuclear medicine specialist to the interested general practitioner and geriatrician. It is the second volume of a trilogy on PET and SPECT imaging in the neurosciences, the other volumes covering PET and SPECT in psychiatry and in neurobiological systems.

  7. Respiratory gating in cardiac PET

    DEFF Research Database (Denmark)

    Lassen, Martin Lyngby; Rasmussen, Thomas; Christensen, Thomas E

    2016-01-01

    of our study was to compare the resulting imaging quality by the use of a time-based respiratory gating system in two groups administered either adenosine or dipyridamole as the pharmacological stress agent. METHODS AND RESULTS: Forty-eight patients were randomized to adenosine or dipyridamole cardiac...... stress (82)RB-PET. Respiratory rates and depths were measured by a respiratory gating system in addition to registering actual respiratory rates. Patients undergoing adenosine stress showed a decrease in measured respiratory rate from initial to later scan phase measurements [12.4 (±5.7) vs 5.6 (±4......BACKGROUND: Respiratory motion due to breathing during cardiac positron emission tomography (PET) results in spatial blurring and erroneous tracer quantification. Respiratory gating might represent a solution by dividing the PET coincidence dataset into smaller respiratory phase subsets. The aim...

  8. Particle Accelerators for PET radionuclides

    DEFF Research Database (Denmark)

    Jensen, Mikael

    2012-01-01

    The requirements set for particle accelerators for production of radioactive isotopes for PET can easily be derived from first principles. The simple general need is for proton beams with energy in the region 10–20 MeV and current 20–100 microAmps. This is most reliably and cost-effectively achie......The requirements set for particle accelerators for production of radioactive isotopes for PET can easily be derived from first principles. The simple general need is for proton beams with energy in the region 10–20 MeV and current 20–100 microAmps. This is most reliably and cost...... different manufacturers will be discussed the light of what is actually needed for a given PET site operation. Alternatives to the conventional cyclotron have been proposed and tested but have at present very limited use. These alternatives will be discussed, as well as the future possibilities of supplying...

  9. 36 CFR 13.1106 - Pets.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Pets. 13.1106 Section 13.1106 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK... Provisions § 13.1106 Pets. Pets are prohibited except— (a) On the Bartlett Cove Public Use Dock; (b) On...

  10. Pets in the family: practical approaches.

    Science.gov (United States)

    Hodgson, Kate; Darling, Marcia

    2011-01-01

    Adapting family life cycle theory to include pets provides veterinarians with a framework for understanding and reinforcing the human-animal bond. The family genogram with pets is a practice tool that identifies all people and pets in the family, enhancing the practice of One Health at the community level.

  11. 7 CFR 503.11 - Pets.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Pets. 503.11 Section 503.11 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.11 Pets. No pets or animals of any kind may be...

  12. 36 CFR 13.978 - Pets.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Pets. 13.978 Section 13.978 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK... (fda) § 13.978 Pets. Possessing a pet is prohibited— (a) In the FDA, except in public parking areas,...

  13. 7 CFR 500.10 - Pets.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Pets. 500.10 Section 500.10 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE NATIONAL ARBORETUM Conduct on U.S. National Arboreturm Property § 500.10 Pets. Pets brought upon...

  14. 36 CFR 13.1310 - Pets.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Pets. 13.1310 Section 13.1310... SYSTEM UNITS IN ALASKA Special Regulations-Kenai Fjords National Park General Provisions § 13.1310 Pets. (a) Pets are prohibited— (1) In the Exit Glacier Developed Area except in the parking lot, on...

  15. 36 CFR 13.1234 - Pets.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Pets. 13.1234 Section 13.1234 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK... § 13.1234 Pets. Possessing a pet in the BCDA is prohibited....

  16. The modification behaviour for Si implanted PET

    Institute of Scientific and Technical Information of China (English)

    吴瑜光; 张通和; 刘安东; 张旭; 周固

    2003-01-01

    Polyethylene terephthalate (PET) has been modified by Si ion implantation with a dose ranging from 1 × 1016 to 2 × 1017 ions /cm2 using a metal vapor vacuum arc(MEVVA)source. The surface morphology was observed by atomic force microscopy (AFM). The change in the microstructure of Si implanted PET was observed with a transmission electron microscope (TEM). It is believed that the change would improve the conductive properties and wear resistance. The electrical properties of PET have been improved via Si ion implantation. The resistivity of implanted PET decreased obviously with an increase in ion dose. When Si ion dose was 2 × 1017 cm?2, the resistivity of PET could be less than 7.9 Ω@m. The surface hardness and modulus increased obviously. The mechanical property of the implanted PET has been modified greatly. The hardness and modulus of Si implanted PET with a dose of 2 × 1017/cm2 are 12.5 and 2.45 times greater than those of pristine PET, respectively. The area of cutting groove for Si implanted PET is narrower and shallower than those of the unimplanted PET. So the wear resistance is greatly raised. In comparison with metal ion implantation, the improvement of mechanical properties is obvious in ion implantation into PET. Si ion beam modification mechanism of PET is discussed.

  17. Pet therapy: dogs de-stress students.

    Science.gov (United States)

    Young, Judith S

    2012-01-01

    Research supports the efficacy of the human-animal bond and pet therapy in a variety of settings. At nursing students' request at one school, the author began offering pet therapy prior to examinations. Anecdotal evidence of a study with the author's Golden Retriever, Goldilocks, demonstrates that pet therapy can reduce test anxiety and improve nursing student performance.

  18. THE CHARACTERISTICS OF EEC PET INSTRUMENTATION

    NARCIS (Netherlands)

    PAANS, AMJ

    1991-01-01

    As a result of a Guide-Questionnaire distributed among all European PET centers an inventory of the European PET instrumentation has become available in a data base. An overview and analysis of the European PET equipment, cyclotrons, scanners and software, together with some global information on th

  19. Initial clinical results for breath-hold CT-based processing of respiratory-gated PET acquisitions

    Energy Technology Data Exchange (ETDEWEB)

    Fin, Loic; Daouk, Joel; Morvan, Julie; Esper, Isabelle El; Saidi, Lazhar; Meyer, Marc-Etienne [Amiens University Hospital, Nuclear Medicine Department, Amiens (France); Bailly, Pascal [Amiens University Hospital, Nuclear Medicine Department, Amiens (France); CHU d' Amiens, Service de Medecine Nucleaire, unite TEP, Hopital Sud, Amiens cedex (France)

    2008-11-15

    Respiratory motion causes uptake in positron emission tomography (PET) images of chest structures to spread out and misregister with the CT images. This misregistration can alter the attenuation correction and thus the quantisation of PET images. In this paper, we present the first clinical results for a respiratory-gated PET (RG-PET) processing method based on a single breath-hold CT (BH-CT) acquisition, which seeks to improve diagnostic accuracy via better PET-to-CT co-registration. We refer to this method as ''CT-based'' RG-PET processing. Thirteen lesions were studied. Patients underwent a standard clinical PET protocol and then the CT-based protocol, which consists of a 10-min List Mode RG-PET acquisition, followed by a shallow end-expiration BH-CT. The respective performances of the CT-based and clinical PET methods were evaluated by comparing the distances between the lesions' centroids on PET and CT images. SUV{sub MAX} and volume variations were also investigated. The CT-based method showed significantly lower (p=0.027) centroid distances (mean change relative to the clinical method =-49%; range =-100% to 0%). This led to higher SUV{sub MAX} (mean change =+33%; range =-4% to 69%). Lesion volumes were significantly lower (p=0.022) in CT-based PET volumes (mean change =-39%: range =-74% to -1%) compared with clinical ones. A CT-based RG-PET processing method can be implemented in clinical practice with a small increase in radiation exposure. It improves PET-CT co-registration of lung lesions and should lead to more accurate attenuation correction and thus SUV measurement. (orig.)

  20. Measurement of σ (e+e− → Hνν)×BR(H → ττ) at CLIC @ 350 GeV

    CERN Document Server

    Münnich, A

    2012-01-01

    This detector benchmark study evaluates the statistical precision with which the H → ττ branching ratio times cross section can be measured at CLIC running at s = 350 GeV. Only the hadronic decay of τs are considered. Results for MH = 126 GeV and 500 fb−1 of integrated luminosity are obtained using full de- tector simulation and including beam-induced backgrounds resulting in a statistical accuracy of cross section times branching ratio of 6.2%.

  1. Measuring cardiac efficiency using PET/MRI

    Energy Technology Data Exchange (ETDEWEB)

    Gullberg, Grand [Lawrence Berkeley National Laboratory (United States); Aparici, Carina Mari; Brooks, Gabriel [University of California San Francisco (United States); Liu, Jing; Guccione, Julius; Saloner, David; Seo, Adam Youngho; Ordovas, Karen Gomes [Lawrence Berkeley National Laboratory (United States)

    2015-05-18

    Heart failure (HF) is a complex syndrome that is projected by the American Heart Association to cost $160 billion by 2030. In HF, significant metabolic changes and structural remodeling lead to reduced cardiac efficiency. A normal heart is approximately 20-25% efficient measured by the ratio of work to oxygen utilization (1 ml oxygen = 21 joules). The heart requires rapid production of ATP where there is complete turnover of ATP every 10 seconds with 90% of ATP produced by mitochondrial oxidative metabolism requiring substrates of approximately 30% glucose and 65% fatty acids. In our preclinical PET/MRI studies in normal rats, we showed a negative correlation between work and the influx rate constant for 18FDG, confirming that glucose is not the preferred substrate at rest. However, even though fatty acid provides 9 kcal/gram compared to 4 kcal/gram for glucose, in HF the preferred energy source is glucose. PET/MRI offers the potential to study this maladapted mechanism of metabolism by measuring work in a region of myocardial tissue simultaneously with the measure of oxygen utilization, glucose, and fatty acid metabolism and to study cardiac efficiency in the etiology of and therapies for HF. MRI is used to measure strain and a finite element mechanical model using pressure measurements is used to estimate myofiber stress. The integral of strain times stress provides a measure of work which divided by energy utilization, estimated by the production of 11CO2 from intravenous injection of 11C-acetate, provides a measure of cardiac efficiency. Our project involves translating our preclinical research to the clinical application of measuring cardiac efficiency in patients. Using PET/MRI to develop technologies for studying myocardial efficiency in patients, provides an opportunity to relate cardiac work of specific tissue regions to metabolic substrates, and measure the heterogeneity of LV efficiency.

  2. Competitive advantage of PET/MRI.

    Science.gov (United States)

    Jadvar, Hossein; Colletti, Patrick M

    2014-01-01

    Multimodality imaging has made great strides in the imaging evaluation of patients with a variety of diseases. Positron emission tomography/computed tomography (PET/CT) is now established as the imaging modality of choice in many clinical conditions, particularly in oncology. While the initial development of combined PET/magnetic resonance imaging (PET/MRI) was in the preclinical arena, hybrid PET/MR scanners are now available for clinical use. PET/MRI combines the unique features of MRI including excellent soft tissue contrast, diffusion-weighted imaging, dynamic contrast-enhanced imaging, fMRI and other specialized sequences as well as MR spectroscopy with the quantitative physiologic information that is provided by PET. Most evidence for the potential clinical utility of PET/MRI is based on studies performed with side-by-side comparison or software-fused MRI and PET images. Data on distinctive utility of hybrid PET/MRI are rapidly emerging. There are potential competitive advantages of PET/MRI over PET/CT. In general, PET/MRI may be preferred over PET/CT where the unique features of MRI provide more robust imaging evaluation in certain clinical settings. The exact role and potential utility of simultaneous data acquisition in specific research and clinical settings will need to be defined. It may be that simultaneous PET/MRI will be best suited for clinical situations that are disease-specific, organ-specific, related to diseases of the children or in those patients undergoing repeated imaging for whom cumulative radiation dose must be kept as low as reasonably achievable. PET/MRI also offers interesting opportunities for use of dual modality probes. Upon clear definition of clinical utility, other important and practical issues related to business operational model, clinical workflow and reimbursement will also be resolved.

  3. Fluorine-18 labeled tracers for PET studies in the neurosciences

    Energy Technology Data Exchange (ETDEWEB)

    Ding, Yu-Shin; Fowler, J.S.

    1995-12-31

    This chapter focuses on fluorine-18, the positron emitter with the longest half-life, the lowest positron energy and probably, the most challenging chemistry. The incorporation of F-18 into organic compounds presents many challenges, including: the need to synthesize and purify the compound within a 2--3 hour time frame; the limited number of labeled precursor molecules; the need to work on a microscale; and the need to produce radiotracers which are chemically and radiochemically pure, sterile and pyrogen-free, and suitable for intravenous injection. The PET method and F-18 labeling of organic molecules are described followed by highlights of the applications of F-18 labeled compounds in the neurosciences and neuropharmacology. It is important to emphasize the essential and pivotal role that organic synthesis has played in the progression of the PET field over the past twenty years from one in which only a handful of institutions possessed the instrumentation and staff to carry out research to the present-day situation where there are more than 200 PET centers worldwide. During this period PET has become an important scientific tool in the neurosciences, cardiology and oncology. It is important to point out that PET is by no means a mature field. The fact that a hundreds of different F-18 labeled compounds have been developed but only a few possess the necessary selectivity and sensitivity in vivo to track a specific biochemical process illustrates this and underscores a major difficulty in radiotracer development, namely the selection of priority structures for synthesis and the complexities of the interactions between chemical compounds and living systems. New developments in rapid organic synthesis are needed in order to investigate new molecular targets and to improve the quantitative nature of PET experiments.

  4. In-vivo human brain molecular imaging with a brain-dedicated PET/MRI system.

    Science.gov (United States)

    Cho, Zang Hee; Son, Young Don; Choi, Eun Jung; Kim, Hang Keun; Kim, Jeong Hee; Lee, Sang Yoon; Ogawa, Seiji; Kim, Young Bo

    2013-02-01

    Advances in the new-generation of ultra-high-resolution, brain-dedicated positron emission tomography-magnetic resonance imaging (PET/MRI) systems have begun to provide many interesting insights into the molecular dynamics of the brain. First, the finely delineated structural information from ultra-high-field MRI can help us to identify accurate landmark structures, thereby making it easier to locate PET activation sites that are anatomically well-correlated with metabolic or ligand-specific organs in the neural structures in the brain. This synergistic potential of PET/MRI imaging is discussed in terms of neuroscience and neurological research from both translational and basic research perspectives. Experimental results from the hippocampus, thalamus, and brainstem obtained with (18)F-fluorodeoxyglucose and (11)C-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile are used to demonstrate the potential of this new brain PET/MRI system.

  5. Adhesion of nitrile rubber to UV-assisted surface chemical modified PET fabric, part II: Interfacial characterization of MDI grafted PET

    Energy Technology Data Exchange (ETDEWEB)

    Razavizadeh, Mahmoud; Jamshidi, Masoud, E-mail: mjamshidi@iust.ac.ir

    2016-08-30

    Highlights: • In this research UV-irradiated PET fabric was chemically modified. • The fabric at first carboxylated under UV irradiation using glutaric anhydride, then it was grafted using isocyanate (i.e. MDI). • The surface of the fabric was characterized before and after each treating satge. • The composite samples were prepared and tested for T-Peel test. The surfaces of the fabrics were surface characterized to understand. - Abstract: Fiber to rubber adhesion is an important subject in rubber industry. It is well known that surface treatment (i.e. physical, mechanical and chemical) is an effective method to improve interfacial bonding of fibers and/or fabrics to rubbers. UV irradiation is an effective method which has been used to increase fabric-rubber interfacial interactions. In this research UV assisted chemical modification of PET fabrics was used to increase PET to nitrile rubber (NBR) adhesion. Nitrile rubber is a perfect selection as fuel and oil resistant rubber. However it has weak bonding to PET fabric. For this purpose PET fabric was carboxylated under UV irradiation and then methylenediphenyl diisocyanate (MDI) was grafted on carboxylated PET. The chemical composition of the fabric before and after surface treatment was investigated by X-ray photoelectron spectroscopy (XPS). The sectional morphology of the experimental PET fibers and the interface between rubber compound and PET fabric was studied using scanning electron microscope (SEM). The morphology and structure of the product were analyzed by an energy dispersive X-ray spectrometer (EDX). FTIR-ATR and H NMR analysis were used to assess surface modifications on the PET irradiated fabrics.

  6. Palliative care and compound in household pets.

    Science.gov (United States)

    Gaskins, Jessica L

    2012-01-01

    Palliative care is not a term solely used for humans when discussing health care; the term is also used when discussing veterinary patients. Pets are considered part of the family by pet owners, and they have a special relationship that only another pet owner can fully understand. This article discusses some of the healthcare problems that affect pets (and their owners), statistics on the most commonly used medications for veterinary patients, quality of life, and discussions on the veterinary pharmacist-owner-palliative pet relationship and how compounding pharmacists can prepare patient-specific medications.

  7. The MiniPET: a didactic PET system

    Science.gov (United States)

    Pedro, R.; Silva, J.; Gurriana, L.; Silva, J. M.; Maio, A.; Soares Augusto, J.

    2013-03-01

    The MiniPET project aims to design and build a small PET system. It consists of two 4 × 4 matrices of 16 LYSO scintillator crystals and two PMTs with 16 channels resulting in a low cost system with the essential functionality of a clinical PET instrument. It is designed to illustrate the physics of the PET technique and to provide a didactic platform for the training of students and nuclear imaging professionals as well as for scientific outreach. The PET modules can be configured to test for the coincidence of 511 keV gamma rays. The model has a flexible mechanical setup [1] and can simulate 14 diferent ring geometries, from a configuration with as few as 18 detectors per ring (ring radius phi=51 mm), up to a geometry with 70 detectors per ring (phi=200 mm). A second version of the electronic system [2] allowed measurement and recording of the energy deposited in 4 detector channels by photons from a 137Cs radioactive source and by photons resulting of the annihilation of positrons from a 22Na radioactive source. These energy spectra are used for detector performance studies, as well as angular dependency studies. In this paper, the mechanical setup, the front-end high-speed analog electronics, the digital acquisition and control electronics implemented in a FPGA, as well as the data-transfer interface between the FPGA board and a host PC are described. Recent preliminary results obtained with the 4 active channels in the prototype are also presented.

  8. Development of PET/MRI with insertable PET for simultaneous PET and MR imaging of human brain

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Jin Ho; Choi, Yong, E-mail: ychoi.image@gmail.com; Jung, Jiwoong; Kim, Sangsu; Lim, Hyun Keong; Im, Ki Chun [Department of Electronic Engineering, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 121-742 (Korea, Republic of); Oh, Chang Hyun; Park, Hyun-wook [Department of Electrical Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701 (Korea, Republic of); Kim, Kyung Min; Kim, Jong Guk [Korea Institute of Radiological and Medical Science, 75 Nowon-ro, Nowon-gu, Seoul 139-709 (Korea, Republic of)

    2015-05-15

    Purpose: The purpose of this study was to develop a dual-modality positron emission tomography (PET)/magnetic resonance imaging (MRI) with insertable PET for simultaneous PET and MR imaging of the human brain. Methods: The PET detector block was composed of a 4 × 4 matrix of detector modules, each consisting of a 4 × 4 array LYSO coupled to a 4 × 4 Geiger-mode avalanche photodiode (GAPD) array. The PET insert consisted of 18 detector blocks, circularly mounted on a custom-made plastic base to form a ring with an inner diameter of 390 mm and axial length of 60 mm. The PET gantry was shielded with gold-plated conductive fabric tapes with a thickness of 0.1 mm. The charge signals of PET detector transferred via 4 m long flat cables were fed into the position decoder circuit. The flat cables were shielded with a mesh-type aluminum sheet with a thickness of 0.24 mm. The position decoder circuit and field programmable gate array-embedded DAQ modules were enclosed in an aluminum box with a thickness of 10 mm and located at the rear of the MR bore inside the MRI room. A 3-T human MRI system with a Larmor frequency of 123.7 MHz and inner bore diameter of 60 cm was used as the PET/MRI hybrid system. A custom-made radio frequency (RF) coil with an inner diameter of 25 cm was fabricated. The PET was positioned between gradient and the RF coils. PET performance was measured outside and inside the MRI scanner using echo planar imaging, spin echo, turbo spin echo, and gradient echo sequences. MRI performance was also evaluated with and without the PET insert. The stability of the newly developed PET insert was evaluated and simultaneous PET and MR images of a brain phantom were acquired. Results: No significant degradation of the PET performance caused by MR was observed when the PET was operated using various MR imaging sequences. The signal-to-noise ratio of MR images was slightly degraded due to the PET insert installed inside the MR bore while the homogeneity was

  9. A unified Fourier theory for time-of-flight PET data

    Science.gov (United States)

    Li, Yusheng; Matej, Samuel; Metzler, Scott D.

    2016-01-01

    Fully 3D time-of-flight (TOF) PET scanners offer the potential of previously unachievable image quality in clinical PET imaging. TOF measurements add another degree of redundancy for cylindrical PET scanners and make photon-limited TOF-PET imaging more robust than non-TOF PET imaging. The data space for 3D TOF-PET data is five-dimensional with two degrees of redundancy. Previously, consistency equations were used to characterize the redundancy of TOF-PET data. In this paper, we first derive two Fourier consistency equations and Fourier-John equation for 3D TOF PET based on the generalized projection-slice theorem; the three partial differential equations (PDEs) are the dual of the sinogram consistency equations and John’s equation. We then solve the three PDEs using the method of characteristics. The two degrees of entangled redundancy of the TOF-PET data can be explicitly elicited and exploited by the solutions of the PDEs along the characteristic curves, which gives a complete understanding of the rich structure of the 3D x-ray transform with TOF measurement. Fourier rebinning equations and other mapping equations among different types of PET data are special cases of the general solutions. We also obtain new Fourier rebinning and consistency equations (FORCEs) from other special cases of the general solutions, and thus we obtain a complete scheme to convert among different types of PET data: 3D TOF, 3D non-TOF, 2D TOF and 2D non-TOF data. The new FORCEs can be used as new Fourier-based rebinning algorithms for TOF-PET data reduction, inverse rebinnings for designing fast projectors, or consistency conditions for estimating missing data. Further, we give a geometric interpretation of the general solutions—the two families of characteristic curves can be obtained by respectively changing the azimuthal and co-polar angles of the biorthogonal coordinates in Fourier space. We conclude the unified Fourier theory by showing that the Fourier consistency equations

  10. A unified Fourier theory for time-of-flight PET data.

    Science.gov (United States)

    Li, Yusheng; Matej, Samuel; Metzler, Scott D

    2016-01-21

    Fully 3D time-of-flight (TOF) PET scanners offer the potential of previously unachievable image quality in clinical PET imaging. TOF measurements add another degree of redundancy for cylindrical PET scanners and make photon-limited TOF-PET imaging more robust than non-TOF PET imaging. The data space for 3D TOF-PET data is five-dimensional with two degrees of redundancy. Previously, consistency equations were used to characterize the redundancy of TOF-PET data. In this paper, we first derive two Fourier consistency equations and Fourier-John equation for 3D TOF PET based on the generalized projection-slice theorem; the three partial differential equations (PDEs) are the dual of the sinogram consistency equations and John's equation. We then solve the three PDEs using the method of characteristics. The two degrees of entangled redundancy of the TOF-PET data can be explicitly elicited and exploited by the solutions of the PDEs along the characteristic curves, which gives a complete understanding of the rich structure of the 3D x-ray transform with TOF measurement. Fourier rebinning equations and other mapping equations among different types of PET data are special cases of the general solutions. We also obtain new Fourier rebinning and consistency equations (FORCEs) from other special cases of the general solutions, and thus we obtain a complete scheme to convert among different types of PET data: 3D TOF, 3D non-TOF, 2D TOF and 2D non-TOF data. The new FORCEs can be used as new Fourier-based rebinning algorithms for TOF-PET data reduction, inverse rebinnings for designing fast projectors, or consistency conditions for estimating missing data. Further, we give a geometric interpretation of the general solutions--the two families of characteristic curves can be obtained by respectively changing the azimuthal and co-polar angles of the biorthogonal coordinates in Fourier space. We conclude the unified Fourier theory by showing that the Fourier consistency equations are

  11. Cardiac (82)Rb PET/CT for fast and non-invasive assessment of microvascular function and structure in asymptomatic patients with type 2 diabetes

    DEFF Research Database (Denmark)

    von Scholten, Bernt J; Hasbak, Philip; Christensen, Thomas E

    2016-01-01

    AIMS/HYPOTHESIS: Coronary flow reserve (CFR) and coronary artery calcium (CAC) represent functional and structural aspects of atherosclerosis. We examined the prevalence of reduced CFR and high CAC scores in three predefined groups of participants without known cardiovascular disease: (1) patients.......026). In multivariate regression analysis, a higher urinary albumin excretion rate (UAER) tended to predict reduced CFR in the total population (p = 0.045). When the CAC score was added, there was also a trend (p = 0.032) towards an inverse association with reduced CFR. CONCLUSIONS/INTERPRETATION: Type 2 diabetic...

  12. Effect of Attenuation Correction on Regional Quantification Between PET/MR and PET/CT

    DEFF Research Database (Denmark)

    Teuho, Jarmo; Johansson, Jarkko; Linden, Jani;

    2016-01-01

    UNLABELLED: A spatial bias in brain PET/MR exists compared with PET/CT, because of MR-based attenuation correction. We performed an evaluation among 4 institutions, 3 PET/MR systems, and 4 PET/CT systems using an anthropomorphic brain phantom, hypothesizing that the spatial bias would be minimized...... with CT-based attenuation correction (CTAC). METHODS: The evaluation protocol was similar to the quantification of changes in neurologic PET studies. Regional analysis was conducted on 8 anatomic volumes of interest (VOIs) in gray matter on count-normalized, resolution-matched, coregistered data. On PET....../MR systems, CTAC was applied as the reference method for attenuation correction. RESULTS: With CTAC, visual and quantitative differences between PET/MR and PET/CT systems were minimized. Intersystem variation between institutions was +3.42% to -3.29% in all VOIs for PET/CT and +2.15% to -4.50% in all VOIs...

  13. PET and SPECT in psychiatry

    Energy Technology Data Exchange (ETDEWEB)

    Dierckx, Rudi A.J.O. [University Medical Center Groningen (Netherlands). Dept. of Nuclear Medicine and Molecular Imaging; Ghent Univ. (Belgium); Otte, Andreas [Univ. of Applied Sciences Offenburg (Germany). Faculty of Electrical Engineering and Information Technology; Vries, Erik F.J. de; Waarde, Aren van (eds.) [University Medical Center Groningen (Netherlands). Dept. of Nuclear Medicine and Molecular Imaging

    2014-09-01

    Covers classical psychiatric disorders as well as other subjects such as suicide, sleep, eating disorders, and autism. Emphasis on a multidisciplinary approach. Written by internationally acclaimed experts. PET and SPECT in Psychiatry showcases the combined expertise of renowned authors whose dedication to the investigation of psychiatric disease through nuclear medicine technology has achieved international recognition. The classical psychiatric disorders as well as other subjects - such as suicide, sleep, eating disorders, and autism - are discussed and the latest results in functional neuroimaging are detailed. Most chapters are written jointly by a clinical psychiatrist and a nuclear medicine expert to ensure a multidisciplinary approach. This state of the art compendium will be valuable to all who have an interest in the field of neuroscience, from the psychiatrist and the radiologist/nuclear medicine specialist to the interested general practitioner and cognitive psychologist. It is the first volume of a trilogy on PET and SPECT imaging in the neurosciences; other volumes will focus on PET and SPECT in neurology and PET and SPECT of neurobiological systems.

  14. SPECT og PET i neurobiologien

    DEFF Research Database (Denmark)

    Paulson, O.B.; Lassen, N.A.

    1997-01-01

    PET (positron emission tomography) and SPECT (single photon emission computed tomography) are isotopic methods in which the distribution is registered of radiolabelled tracers given in such small amounts that they are without effect on the organism or the organism's disposal of them. Thus, a series...

  15. Comparison of threshold-based and watershed-based segmentation for the truncation compensation of PET/MR images

    NARCIS (Netherlands)

    Blaffert, T.; Renisch, S.; Tang, J.; Narayanan, M.; Hu, Z.

    2012-01-01

    Recently introduced combined PET/MR scanners need to handle the specific problem that a limited MR field of view sometimes truncates armor body contours, which prevents an accurate calculation of PET attenuation correction maps. Such maps of attenuation coefficients overbody structures are required

  16. High-resolution imaging of human atherosclerotic carotid plaques with micro(18)F-FDG PET scanning exploring plaque vulnerability

    NARCIS (Netherlands)

    Masteling, Marleen G.; Zeebregts, Clark J.; Tio, Rene A.; Breek, Jan-Cees; Tietge, Uwe J. F.; de Boer, Jan Freark; Glaudemans, Andor W. J. M.; Dierckx, Rudi A. J. O.; Boersma, Hendrikus H.; Slart, Riemer H. J. A.

    2011-01-01

    FDG-PET can be used to identify vulnerable plaques in atherosclerotic disease. Clinical FDG-PET camera systems are restricted in terms of resolution for the visualization of detailed inflammation patterns in smaller vascular structures. The aim of the study is to evaluate the possible added value of

  17. Recyclability of PET from virgin resin

    Directory of Open Access Journals (Sweden)

    Mancini Sandro Donnini

    1999-01-01

    Full Text Available Bottle grade virgin PET (polyethylene terephthalate resin was investigated through five consecutive injection molding steps to simulate recycling cycles. Tests were carried out after each recycling to evaluate degradation, crystallinity (by density and Differential Scanning Calorimetry-DSC measurements, hardness, and tensile and flexural properties. Consecutive recycling resulted in cumulative chain breaks caused by the material's contact with degrading agents such as temperature, oxygen, mechanical stresses, light, and water. In the fifth recycling step, for example, the number of carboxylic end groups, an indicator of the extent of chain-break, tripled in comparison to the initial molecule. The smaller chains that were formed fit more easily among the larger ones, thus increasing the percentage of crystalline phase in the structure. These two changes in the polymer's structure explained the recycled products' final properties, i.e., the injected samples became progressively harder and more fragile in each recycling step.

  18. Postnatal development of hypoplastic thymus in semi-lethal dwarf pet/pet males.

    Science.gov (United States)

    Chiba, Junko; Suzuki, Hiroetsu; Aoyama, Hiroaki; Katayama, Kentaro; Suzuki, Katsushi

    2011-04-01

    The petit rat (pet/pet) is a new semi-lethal dwarf mutant with anomalies in the thymus and testes, defects inherited as a single autosomal recessive trait. At birth, these pet/pet rats show low birth weight and extremely small thymuses; at 140 days of age, their thymuses show abnormal involution. In the present study, we examined early postnatal development of hypoplastic pet/pet thymuses. In addition to being hypoplastic at birth, pet/pet thymus growth was almost completely impaired during the early postnatal period. As shown by cellular incorporation of BrdU, the mitotic activity was lower in pet/pet than in normal thymuses, and terminal deoxynucleotidyl transferase dUTP nick end labeling assays showed that apoptosis occurred more often in pet/pet than in normal thymus cells during the first few days after birth. These results indicate that postnatal development of the hypoplastic pet/pet thymus is defective due to the reduced proliferation and increased apoptosis of thymic cells.

  19. PET/MRI for Preoperative Planning in Patients with Soft Tissue Sarcoma

    DEFF Research Database (Denmark)

    Loft Jakobsen, Annika; Jensen, Karl Erik; L�fgren, Johan;

    2013-01-01

    Clinical positron emission tomography (PET)/magnetic resonance imaging (MRI) acquisition protocols may improve the evaluation of soft tissue sarcomas (STS) prior to surgical planning. We examined two patients with lower extremity STS using a Siemens Biograph mMR PET/MRI scanner and the glucose...... analogue 18F-fluoro-deoxyglucose (FDG). We investigated clinically relevant tumor volumes and evaluated the relations to skeletal periosteum and nerve bundles. The patient scans suggest that FDG PET/MRI improved the edge detection, and invasion of tumor tissue into important adjacent anatomical structures...... planning, including radiation therapy planning in patients with STS....

  20. (18)F-Fluorodeoxyglucose PET/Computed Tomography for Primary Brain Tumors

    DEFF Research Database (Denmark)

    Antonsen Segtnan, Eivind; Hess, Søren; Grupe, Peter

    2015-01-01

    Structural imaging with computed tomography (CT) and MR imaging is the mainstay in primary diagnosis of primary brain tumors, but these modalities depend on morphologic appearance and an intact blood-brain barrier, and important aspects of tumor biology are not addressed. Such issues may...... be alleviated by (18)F-fluorodeoxyglucose (FDG)-PET and FDG-PET/CT imaging, which may provide clinically important information with regard to primary differentiation between tumor types, initial staging and risk stratification, therapy planning, response evaluation, and recurrence detection. This article...... describes some of the potential contemporary applications of FDG and PET in primary brain tumors....

  1. The Pet-Fish problem on the World-Wide Web

    CERN Document Server

    Aerts, Diederik; D'Hooghe, Bart; Sozzo, Sandro

    2010-01-01

    We identify the presence of Pet-Fish problem situations and the corresponding Guppy effect of concept theory on the World-Wide Web. For this purpose, we introduce absolute weights for words expressing concepts and relative weights between words expressing concepts, and the notion of 'meaning bound' between two words expressing concepts, making explicit use of the conceptual structure of the World-Wide Web. The Pet-Fish problem occurs whenever there are exemplars - in the case of Pet and Fish these can be Guppy or Goldfish - for which the meaning bound with respect to the conjunction is stronger than the meaning bounds with respect to the individual concepts.

  2. High Power Test on an x-Band Slotted-Iris Accelerator Structure at NLCTA

    CERN Document Server

    Adolphsen, C; Fandos, R; Grudiev, A; Heikkinen, S; Laurent, L; Rodríguez, José Alberto; Taborelli, M; Wuensch, W

    2007-01-01

    The CLIC study group at CERN has built two X-band HDS (Hybrid Damped Structure) accelerating structures for high-power testing in NLCTA at SLAC. These accelerating structures are novel with respect to their rf-design and their fabrication technique. The eleven-cell constant impedance structures, one made out of copper and one out of molybdenum, are assembled from clamped high-speed milled quadrants. They feature the same heavy higher-order-mode damping as nominal CLIC structures achieved by slotted irises and radial damping waveguides for each cell. The X-band accelerators are exactly scaled versions of structures tested at 30 GHz in the CLIC test facility, CTF3. The results of the X-band tests are presented and compared to those at 30 GHz to determine frequency scaling, and are compared to the extensive copper data from the NLC structure development program to determine material dependence and make a basic validation of the HDS design. INTRODUCTION

  3. Physics performances for Scalar Electron, Scalar Muon and Scalar Neutrino searches at 3 TeV and 1.4 TeV at CLIC

    CERN Document Server

    Battaglia, Marco; Marshall, John S; Thomson, Mark; Sailer, Andre; Poss, Stephan; van der Kraaij, Erik

    2013-01-01

    The determination of scalar lepton and gaugino masses is an important part of the programme of spectroscopic studies of Supersymmetry at a high energy e+e- linear collider. In this article we present results of a study of the processes: e+e- -> eR eR -> e+e- chi0 chi, e+e- -> muR muR -> mu mu- chi0 chi0, e+e- -> eL eL -> e e chi0 chi0 and e+e- -> snu_e snu_e -> e e chi+ chi-in two Supersymmetric benchmark scenarios at 3 TeV and 1.4 TeV at CLIC. We characterize the detector performance, lepton energy resolution and boson mass resolution. We report the accuracy of the production cross section measurements and the eR muR, snu_e, chi+ and chi0 mass determination, estimate the systematic errors affecting the mass measurement and discuss the requirements on the detector time stamping capability and beam polarization. The analysis accounts for the CLIC beam energy spectrum and the dominant beam-induced background. The detector performances are incorporated by full simulation and reconstruction of the events within t...

  4. PET/PCTG比例对共混材料热性能影响%Influence of PET/PCTG Ratio on Thermal Properties of Blends

    Institute of Scientific and Technical Information of China (English)

    李敏雯; 张钦发; 李夏君; 张义珂

    2016-01-01

    聚对苯二甲酸乙二醇/环已烷二甲醇酯(PCTG)由于其具有较高的玻璃化温度且与PET具有结构上的相似性,PET与PCTG共混有助提高材料的耐热性能.研究PET与PCTG共混材料的热性能可为共混材料成型加工提供理论基础.文章对不同比例PET/PCTG共混材料进行升温和降温差示扫描量热分析(DSC),研究了不同比例PET/PCTG共混材料的冷、热结晶性能.研究结果表明:不同比例的PET/PCTG共混材料的冷、热结晶峰值温度不相同,当PET/PCTG比例为7:3时,其冷结晶峰值温度最低,结晶熔融峰值温度和热结晶峰值温度最高.%Poly((ethylene-co-cyclohexane1,4-dimethanol) terephthalate (PCTG) was similar in chemical structure and higher glass transition temperature compared with PET.Heat durability and impact strength of PET/PCTG bottles could be improved by blending with PCTG.Study on thermal properties of PET/PCTG blends were the basis of molding and processing conditions for PET/PCTG blends.The crystallinity of various PET/PCTG blends had been researched by analyzed using differential scanning calorimetry (DSC),results showed that crystallization temperature and melting temperature of blends with various PET/PCTG ratio were different,cold peak crystallization temperature of PET/PCTG blends were lowest,and heat peak crystallization temperature and peak melting temperature were highest when PET/PCTG was 7:3.

  5. PET in cerebrovascular disease; PET bei zerebrovaskulaeren Erkrankungen

    Energy Technology Data Exchange (ETDEWEB)

    Herholz, K. [Neurologische Universitaetsklinik der Univ. Koeln (Germany)]|[Max-Planck-Institut fuer Neurologische Forschung, Koeln (Germany)

    1997-03-01

    Tissue viability is of particular interest in acute cerebral ischemia because it may be preserved if reperfusion can be achieved rapidly, e.g. by acute thrombolysis. Measurements of regional cerebral blood flow (CBF) and oxygen consumption by PET can assess tissue viability, and they have substantially increased our knowledge of th pathophysiology of ischemic stroke and the associated penumbra. Widerspread clinical application in acute stroke, however, is unlikely because of the large logistic and personnel resources required. In chronic cerebrovascular disease, measurement of regional CBF and glucose metabolism, which is usually coupled, provide detailed insights in disturbance of cortical function, e.g. due to deafferentiation, and contribute to differentiation of dementia types. Chronic misery perfusion, i.e. reduced perfusion that does not match the metabolic demand of the tissue, can be demonstrated by PET. It may be found in some patients with high-grade arterial stenoses. Less severe impairment of brain perfusion can be demonstrated by measurement of the cerebrovascular reserve capacity. The most frequent clinical situations can be assessed by less demanding procedures, e.g. by SPECT. In conclusion, PET has its role in cerebrovascular disease primarily within scientific studies, where high resolution and absolute quantitation of physiological variables are essential. (orig.). 65 refs. [Deutsch] Beim akuten ischaemischen Insult ist die Vitalitaet des Gewebes von besonderem Interesse, da sie durch rasche Reperfusion, z.B. durch Thrombolyse, erhalten bleiben kann. Messungen der zerebralen Durchblutung und des Sauerstoffumsatzes mittels PET geben darueber wesentliche Aufschluesse, und sie sind wichtig fuer das Verstaendnis der Pathophysiologie ischaemischer Infarkte und der Penumbra mit kritischer Perfusion beim Menschen. Ihre breitere Anwendung in der klinischen Patientenversorgung kommt allerdings wegen des hohen Aufwandes derzeit kaum in Betracht. Bei

  6. CTF3 Drive Beam Accelerating Structures

    CERN Document Server

    Jensen, E

    2002-01-01

    The 3 GHz drive beam accelerator of the CLIC Test Facility CTF3, currently under construction at CERN, will be equipped with 16 novel SICA (Slotted Iris – Constant Aperture) accelerating structures. The slotted irises couple out the potentially disruptive induced transverse HOM energy to integrated silicon carbide loads (dipole mode Q's below 20). The use of nose cones for detuning allows a constant inner aperture (34 mm). The structures will be 1.2 m long and consist of 34 cells. A first 6 cell prototype structure has been tested successfully up to power levels of 100 MW (nominal: 30 MW), corresponding to surface electric field levels of 180 MV/m.

  7. PET/MRI and PET/CT in advanced gynaecological tumours: initial experience and comparison

    Energy Technology Data Exchange (ETDEWEB)

    Queiroz, Marcelo A.; Schulthess, Gustav von; Veit-Haibach, Patrick [University Hospital Zurich, Department Medical Radiology, Nuclear Medicine, Zurich (Switzerland); University Hospital Zurich, Department Medical Radiology, Diagnostic and Interventional Radiology, Zurich (Switzerland); University of Zurich, Zurich (Switzerland); Kubik-Huch, Rahel A.; Freiwald-Chilla, Bianka [Kantonsspital Baden AG, Department of Radiology, Baden (Switzerland); Hauser, Nik [Kantonsspital Baden AG, Department of Gynaecology, Baden (Switzerland); Froehlich, Johannes M. [Guerbet AG, Zurich (Switzerland)

    2015-08-15

    To compare the diagnostic accuracy of PET/MRI and PET/CT for staging and re-staging advanced gynaecological cancer patients as well as identify the potential benefits of each method in such a population. Twenty-six patients with suspicious or proven advanced gynaecological cancer (12 ovarian, seven cervical, one vulvar and four endometrial tumours, one uterine metastasis, and one primary peritoneal cancer) underwent whole-body imaging with a sequential trimodality PET/CT/MR system. Images were analysed regarding primary tumour detection and delineation, loco-regional lymph node staging, and abdominal/extra-abdominal distant metastasis detection (last only by PET/CT). Eighteen (69.2 %) patients underwent PET/MRI for primary staging and eight patients (30.8 %) for re-staging their gynaecological malignancies. For primary tumour delineation, PET/MRI accuracy was statistically superior to PET/CT (p < 0.001). Among the different types of cancer, PET/MRI presented better tumour delineation mainly for cervical (6/7) and endometrial (2/3) cancers. PET/MRI for local evaluation as well as PET/CT for extra-abdominal metastases had therapeutic consequences in three and one patients, respectively. PET/CT detected 12 extra-abdominal distant metastases in 26 patients. PET/MRI is superior to PET/CT for primary tumour delineation. No differences were found in detection of regional lymph node involvement and abdominal metastases detection. (orig.)

  8. Veterinarians' role for pet owners facing pet loss

    OpenAIRE

    Fernandez-Mehler, P.; Gloor, P.; Sager, E.; Lewis, F.I.; Glaus, T. M

    2013-01-01

    Owners' satisfaction with, and expectations from, their veterinarians around euthanasia, including questions on disposal of pet remains subject to animal species, clients' gender, age, family conditions, area of living and type of veterinary clinic visited were evaluated by questionnaire. Questionnaires were to be filled out by clients consecutively visiting the individual practices and hospitals for any kind of consultations. Of 2350 questionnaires distributed, 2008 were returned and availab...

  9. Markerless 3D Head Tracking for Motion Correction in High Resolution PET Brain Imaging

    DEFF Research Database (Denmark)

    Olesen, Oline Vinter

    images. Incorrect motion correction can in the worst cases result in wrong diagnosis or treatment. The evolution of a markerless custom-made structured light 3D surface tracking system is presented. The system is targeted at state-of-the-art high resolution dedicated brain PET scanners with a resolution...... significantly. The results were similar to motion correction using an integrated commercial marker-based system. Furthermore, phantom studies were performed supporting the system’s abilities for PET motion correction....

  10. Comparison and spacial correlation of interictal HMPAO-SPECT and FDG-PET in intractable temporal lobe epilepsy.

    Science.gov (United States)

    Coubes, P; Awad, I A; Antar, M; Magdinec, M; Sufka, B

    1993-06-01

    The respective contribution of interictal HMPAO-SPECT and FDG-PET to the imaging of the epileptogenic zone in intractable temporal lobe epilepsy is not known. Ten consecutive patients with drug resistant focal epilepsy of temporal lobe origin were studied with prolonged noninvasive video-EEG monitoring, magnetic resonance imaging, interictal FDG-PET and HMPAO-SPECT. Five patients demonstrated unitemporal and 5 patients bitemporal interictal and/or ictal EEG epileptiform abnormalities. We developed a 3-dimensional semiquantitative method for interpretation and comparison of FDG-PET and HMPAO-SPECT using a 15-compartment model of the temporal lobe. In all 5 patients with unilateral epileptogenicity, interictal hypometabolism and hypoperfusion were recorded on the side of the EEG abnormalities without discrepancy between PET and SPECT. The severity and the extent of focal abnormalities were consistently greater on PET than on SPECT, in agreement with previously well documented better 'sensitivity' of PET. Among the 5 patients with bitemporal epileptogenicity, results of SPECT and PET were convergent in only 2 cases. In this group, SPECT abnormalities appeared more profound but either SPECT or PET were not constantly correlated with the side of predominant EEG epileptogenicity. Abnormalities on PET and SPECT were more frequently limited to mesiobasal structures among cases with unilateral epileptogenicity and tended to involve neocortical structures in bitemporal cases. We conclude that interictal FDG-PET and HMPAO-SPECT provide the same type of information on the side of the epileptogenic zone in cases with clearly unilateral epileptogenicity, with abnormalities more intense and more extensive on PET.(ABSTRACT TRUNCATED AT 250 WORDS)

  11. Feasibility of simultaneous PET/MR of the carotid artery: first clinical experience and comparison to PET/CT

    DEFF Research Database (Denmark)

    Ripa, Rasmus Sejersten; Knudsen, Andreas; Hag, Anne Mette Fisker;

    2013-01-01

    The study aimed at comparing PET/MR to PET/CT for imaging the carotid arteries in patients with known increased risk of atherosclerosis. Six HIV-positive men underwent sequential PET/MR and PET/CT of the carotid arteries after injection of 400 MBq of 18F-FDG. PET/MR was performed a median of 131 ...

  12. Comparison between PET/MR and PET/CT in evaluation of oncological patients%PET/MR与PET/CT的对比研究

    Institute of Scientific and Technical Information of China (English)

    徐白萱; 富丽萍; 关志伟; 尹大一; 刘家金; 杨晖; 张锦明; 陈英茂; 安宁豫

    2014-01-01

    Objective To verify the feasibility of the integrated PET/MR for oncological applications by comparing PET/MR with PET/CT in terms of lesion detection and quantitative measurement.Methods A total of 277 patients (165 males,112 females,average age (52.9± 12.6) years) voluntarily participated in this same-day PET/CT and PET/MR comparative study.The time interval between the two studies was 15-35 min.PET/CT images were acquired and reconstructed following standard protocols.PET/MR covered the body trunk with a sequence combination of transverse T1 weighted imaging (WI) 3D-volumetric interpolated breath-hold,T2WI turbo spin echo with fat saturation,diffusion-weighted imaging,and simultaneous PET acquisition.PET images were reconstructed by vender-provided attenuation correction methods.The results of PET/CT and PET/MR were regarded as positive if any modality (CT,PET or MRI) was positive.SUVmax was obtained by the manually drawn ROI.Detection rates were compared with x2 test and SUVmax from the two modalities was analyzed with Spearman correlation analysis.Results A total of 353 lesions were detected in 220 patients.Compared to PET/CT,PET/MR revealed 30 additional true-positive lesions,while missed 6.The detection rates between PET/CT and PET/MR were significantly different (P<0.05).The lesion-based and patient-based consistency was 89.8% (317/353) and 85.9% (189/220),respectively.There were significant correlations of SUVmax between PET/MR and PET/CT for lesions(rs =0.91,P<0.01) and for normal tissues(rs =0.62-0.76,all P<0.01).Conclusions With reference to PET/CT,integrated PET/MR may provide comparable semi-quantitative measurements of pathological lesions as well as normal tissues.Integrated PET/MR may be more effective to detect lesions in abdomen and pelvis.%目的 通过与PET/CT在病灶检测及定量分析方面的比较,论证PET/MR一体机应用于临床的可行性.方法 2012年5月至2013年2月共300例患者同天间隔15 ~ 35 min行PET

  13. FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0

    DEFF Research Database (Denmark)

    Boellaard, Ronald; O'Doherty, Mike J; Weber, Wolfgang A;

    2010-01-01

    The aim of this guideline is to provide a minimum standard for the acquisition and interpretation of PET and PET/CT scans with [18F]-fluorodeoxyglucose (FDG). This guideline will therefore address general information about[18F]-fluorodeoxyglucose (FDG) positron emission tomography......-computed tomography (PET/CT) and is provided to help the physician and physicist to assist to carrying out,interpret, and document quantitative FDG PET/CT examinations,but will concentrate on the optimisation of diagnostic quality and quantitative information....

  14. Potential impact of {sup 68}Ga-DOTATOC PET/CT on stereotactic radiotherapy planning of meningiomas

    Energy Technology Data Exchange (ETDEWEB)

    Nyuyki, Fonyuy; Plotkin, Michail; Michel, Roger; Steffen, Ingo; Fahdt, Daniel; Brenner, Winfried [Charite-Universitaetsmedizin Berlin, Department for Nuclear Medicine, Berlin (Germany); Graf, Reinhold [Charite-Universitaetsmedizin Berlin, Department for Radiation Therapy, Campus Virchow, Berlin (Germany); Denecke, Timm [Charite-Universitaetsmedizin Berlin, Department for Radiology, Campus Virchow, Berlin (Germany); Geworski, Lilli [Charite-Universitaetsmedizin Berlin, Department for Nuclear Medicine, Berlin (Germany); Medizinische Hochschule Hannover, Department for Radiation Safety and Medical Physics, Hannover (Germany); Wurm, Reinhard [Charite-Universitaetsmedizin Berlin, Department for Radiation Therapy, Campus Virchow, Berlin (Germany); Klinikum Frankfurt (Oder), Department for Radiation Therapy and Radiooncology, Frankfurt (Germany)

    2010-02-15

    Since meningiomas show a high expression of somatostatin receptor subtype 2, PET with {sup 68}Ga-DOTATOC was proposed as an additional imaging modality beside CT and MRI for planning radiotherapy. We investigated the input of {sup 68}Ga-DOTATOC-PET/CT on the definition of the ''gross tumour volume'' (GTV) in meningiomas, in order to assess the potential value of this method. Prior to radiotherapy, 42 patients with meningiomas (26 f, 16 m, mean age 55) underwent MRI and {sup 68}Ga-DOTATOC-PET/CT examinations. History: operated n = 24, radiotherapy n = 1, operation and radiotherapy n = 8, no treatment n = 9. PET/CT and MRI data were co-registered using a BrainLAB workstation. For comparison, the GTV was defined first under consideration of CT and MRI data, then using PET data. 3/42 patients were excluded from the analysis (two with negative PET results, one with an extensive tumour, not precisely delineable by MRI or PET/CT). The average GTV{sub CT/MRI} was 22({+-}19)cm{sup 3}; GTV{sub PET} was 23({+-}20)cm{sup 3}. Additional GTV, obtained as a result of PET was 9({+-}10)cm{sup 3} and was observed in patients with osseous infiltration. In some pre-treated patients there were intratumoural areas (as identified in CT/MRI) without SR-expression (7({+-}11)cm{sup 3}). Common GTV as obtained by both CT/MRI and PET was 15({+-}14)cm{sup 3}. The mean bi-directional difference between the GTV{sub CT/MRI} and GTV{sub PET} accounted to 16({+-}15)cm{sup 3} (93%, p < 0.001). In a subgroup of seven patients with multiple meningiomas, PET showed a total of 19 lesions; nine of them were not recognizable by CT or MRI. {sup 68}Ga-DOTATOC-PET enables delineation of SR-positive meningiomas and delivers additional information to both CT and MRI regarding the planning of stereotactic radiotherapy. The acquisition on a PET/CT scanner helps to estimate the relation of PET findings to anatomical structures and is especially useful for detection of osseous infiltration

  15. Phase Field Modeling Using PetIGA

    KAUST Repository

    Vignal, Philippe A.

    2013-06-01

    Phase field modeling has become a widely used framework in the computational material science community. Its ability to model different problems by defining appropriate phase field parameters and relating it to a free energy functional makes it highly versatile. Thermodynamically consistent partial differential equations can then be generated by assuming dissipative dynamics, and setting up the problem as one of minimizing this free energy. The equations are nonetheless challenging to solve, and having a highly efficient and parallel framework to solve them is necessary. In this work, a brief review on phase field models is given, followed by a short analysis of the Phase Field Crystal Model solved with Isogeometric Analysis us- ing PetIGA. We end with an introduction to a new modeling concept, where free energy functions are built with a periodic equilibrium structure in mind.

  16. PET/MRI in cancer patients

    DEFF Research Database (Denmark)

    Kjær, Andreas; Loft, Annika; Law, Ian

    2013-01-01

    Combined PET/MRI systems are now commercially available and are expected to change the medical imaging field by providing combined anato-metabolic image information. We believe this will be of particular relevance in imaging of cancer patients. At the Department of Clinical Physiology, Nuclear...... described include brain tumors, pediatric oncology as well as lung, abdominal and pelvic cancer. In general the cases show that PET/MRI performs well in all these types of cancer when compared to PET/CT. However, future large-scale clinical studies are needed to establish when to use PET/MRI. We envision...... that PET/MRI in oncology will prove to become a valuable addition to PET/CT in diagnosing, tailoring and monitoring cancer therapy in selected patient populations....

  17. Child vs. Pet: The Effect of Abortion Legalization on the Demand for Pets

    OpenAIRE

    Youjin Hahn; Liang Choon Wang; Hee-Seung Yang

    2012-01-01

    This paper examines whether abortion legalization led to increased demand for pets in the United States. We compare women living in early-legalizing states, whose peak childbearing years occurred in the early 1970s, to women in other states and cohorts and estimate their likelihood of pet ownership and time spent on pets after their peak childbearing years were over. We find the probability of owning any pet is approximately 9.6 percentage points higher for women affected by abortion legaliza...

  18. Joint PET-MR respiratory motion models for clinical PET motion correction

    Science.gov (United States)

    Manber, Richard; Thielemans, Kris; Hutton, Brian F.; Wan, Simon; McClelland, Jamie; Barnes, Anna; Arridge, Simon; Ourselin, Sébastien; Atkinson, David

    2016-09-01

    Patient motion due to respiration can lead to artefacts and blurring in positron emission tomography (PET) images, in addition to quantification errors. The integration of PET with magnetic resonance (MR) imaging in PET-MR scanners provides complementary clinical information, and allows the use of high spatial resolution and high contrast MR images to monitor and correct motion-corrupted PET data. In this paper we build on previous work to form a methodology for respiratory motion correction of PET data, and show it can improve PET image quality whilst having minimal impact on clinical PET-MR protocols. We introduce a joint PET-MR motion model, using only 1 min per PET bed position of simultaneously acquired PET and MR data to provide a respiratory motion correspondence model that captures inter-cycle and intra-cycle breathing variations. In the model setup, 2D multi-slice MR provides the dynamic imaging component, and PET data, via low spatial resolution framing and principal component analysis, provides the model surrogate. We evaluate different motion models (1D and 2D linear, and 1D and 2D polynomial) by computing model-fit and model-prediction errors on dynamic MR images on a data set of 45 patients. Finally we apply the motion model methodology to 5 clinical PET-MR oncology patient datasets. Qualitative PET reconstruction improvements and artefact reduction are assessed with visual analysis, and quantitative improvements are calculated using standardised uptake value (SUVpeak and SUVmax) changes in avid lesions. We demonstrate the capability of a joint PET-MR motion model to predict respiratory motion by showing significantly improved image quality of PET data acquired before the motion model data. The method can be used to incorporate motion into the reconstruction of any length of PET acquisition, with only 1 min of extra scan time, and with no external hardware required.

  19. The Therapeutic Value of Pets

    OpenAIRE

    1986-01-01

    While domestic pets are capable of transmitting disease and inflicting injury, they may also be of benefit to human health. Studies suggest that companion animals, in addition to their well-known role as helpers to the handicapped, may alleviate depression, solace the lonely, facilitate psycho-therapy, socialize criminals, lower blood pressure, increase survivorship from myocardial infarction and ease the social pain of aging in our society.

  20. Critical Care of Pet Birds.

    Science.gov (United States)

    Jenkins, Jeffrey Rowe

    2016-05-01

    Successful care of the critical pet bird patient is dependent on preparation and planning and begins with the veterinarian and hospital staff. An understanding of avian physiology and pathophysiology is key. Physical preparation of the hospital or clinic includes proper equipment and understanding of the procedures necessary to provide therapeutic and supportive care to the avian patient. An overview of patient intake and assessment, intensive care environment, and fluid therapy is included.

  1. PET-Based Personalized Management in Clinical Oncology: An Unavoidable Path for the Foreseeable Future.

    Science.gov (United States)

    Basu, Sandip; Alavi, Abass

    2016-07-01

    It is imperative that the thrust of clinical practice in the ensuing years would be to develop personalized management model for various disorders. PET-computed tomography (PET-CT) based molecular functional imaging has been increasingly utilized for assessment of tumor and other nonmalignant disorders and has the ability to explore disease phenotype on an individual basis and address critical clinical decision making questions related to practice of personalized medicine. Hence, it is essential to make a concerted systematic effort to explore and define the appropriate place of PET-CT in personalized clinical practice in each of malignancies, which would strengthen the concept further. The potential advantages of PET based disease management can be classified into broad categories: (1) Traditional: which includes assessment of disease extent such as initial disease staging and restaging, treatment response evaluation particularly early in the course and thus PET-CT response adaptive decision for continuing the same regimen or switching to salvage schedules; there has been continuous addition of newer application of PET based disease restaging in oncological parlance (eg, Richter transformation); (2) Recent and emerging developments: this includes exploring tumor biology with FDG and non-FDG PET tracers. The potential of multitracer PET imaging (particularly new and novel tracers, eg, 68Ga-DOTA-TOC/NOC/TATE in NET, 68Ga-PSMA and 18F-fluorocholine in prostate carcinoma, 18F-fluoroestradiol in breast carcinoma) has provided a scientific basis to stratify and select appropriate targeted therapies (both radionuclide and nonradionuclide treatment), a major boost for individualized disease management in clinical oncology. Integrating the molecular level information obtained from PET with structural imaging further individualizing treatment plan in radiation oncology, precision of interventions and biopsies of a particular lesion and forecasting disease prognosis.

  2. Thoracic cavity definition for 3D PET/CT analysis and visualization.

    Science.gov (United States)

    Cheirsilp, Ronnarit; Bascom, Rebecca; Allen, Thomas W; Higgins, William E

    2015-07-01

    X-ray computed tomography (CT) and positron emission tomography (PET) serve as the standard imaging modalities for lung-cancer management. CT gives anatomical details on diagnostic regions of interest (ROIs), while PET gives highly specific functional information. During the lung-cancer management process, a patient receives a co-registered whole-body PET/CT scan pair and a dedicated high-resolution chest CT scan. With these data, multimodal PET/CT ROI information can be gleaned to facilitate disease management. Effective image segmentation of the thoracic cavity, however, is needed to focus attention on the central chest. We present an automatic method for thoracic cavity segmentation from 3D CT scans. We then demonstrate how the method facilitates 3D ROI localization and visualization in patient multimodal imaging studies. Our segmentation method draws upon digital topological and morphological operations, active-contour analysis, and key organ landmarks. Using a large patient database, the method showed high agreement to ground-truth regions, with a mean coverage=99.2% and leakage=0.52%. Furthermore, it enabled extremely fast computation. For PET/CT lesion analysis, the segmentation method reduced ROI search space by 97.7% for a whole-body scan, or nearly 3 times greater than that achieved by a lung mask. Despite this reduction, we achieved 100% true-positive ROI detection, while also reducing the false-positive (FP) detection rate by >5 times over that achieved with a lung mask. Finally, the method greatly improved PET/CT visualization by eliminating false PET-avid obscurations arising from the heart, bones, and liver. In particular, PET MIP views and fused PET/CT renderings depicted unprecedented clarity of the lesions and neighboring anatomical structures truly relevant to lung-cancer assessment.

  3. If My Child Has Asthma, Can We Keep Our Pet?

    Science.gov (United States)

    ... Have someone other than your child wash and brush your pet every week (this is advisable for cats as well as dogs). Encourage everyone in the family to wash their hands after playing with your pet. Keep your pet ...

  4. Engineering design and fabrication of tapered damped X-Band accelerating structures

    CERN Document Server

    Solodko, A; Gudkov, D; Riddone, G; Grudiev, A; Atieh, S; Taborelli, M

    2011-01-01

    The accelerating structures (AS) are one of the main components of the Compact LInear Collider (CLIC), under study at CERN. Each accelerating structure contains about 30 copper discs, which form the accelerating cavity. The requirements of different technical systems, such as vacuum and cooling, have to be considered during the engineering design. A fully featured AS is very challenging and requires several technologies. Different damping methods, waveguides, vacuum manifolds, slots and chokes, result in various design configurations. In the CLIC AS each cell is damped by means of four waveguides coupled to the cell. The vacuum manifolds combine a number of functions such as damping, vacuum pumping and cooling. A silicon carbide absorber, fixed inside of each manifold, is required for effective damping of Higher Order Modes (HOMs). This paper describes the engineering design of the X-band AS with damping material, and focuses on few technical solutions.

  5. The AX-PET project Demonstration of a high resolution axial 3D PET

    CERN Document Server

    Bolle, E; Casella, C; Chesi, E; Clinthorne, N; Cochran, E; De Leo, R; Dissertori, G; Djambazov, G; Fanti, V; Honscheid, K; Huh, S; Johnson, I; Joram, C; Kagan, H; Lustermann, W; Meddi, F; Nappi, E; Nessi-Tedaldi, F; Oliver, J F; Pauss, P; Rafecas, M; Renker, D; Rudge, A; Schinzel, D; Schneider, T; Seguinot, J; Smith, S; Solevi, P; Stapnes, S; Weilhammer, P

    2010-01-01

    The AX-PET is a new geometrical concept for a high resolution 3D PET scanner, based on matrices of axially oriented LYSO crystals interleaved by stacks of WLS, both individually read out by G-APDs. A PET demonstrator, based on two detector modules used in coincidence, is currently under construction.

  6. Gallium-68 EDTA PET/CT for Renal Imaging.

    Science.gov (United States)

    Hofman, Michael S; Hicks, Rodney J

    2016-09-01

    Nuclear medicine renal imaging provides important functional data to assist in the diagnosis and management of patients with a variety of renal disorders. Physiologically stable metal chelates like ethylenediaminetetraacetic acid (EDTA) and diethylenetriamine penta-acetate (DTPA) are excreted by glomerular filtration and have been radiolabelled with a variety of isotopes for imaging glomerular filtration and quantitative assessment of glomerular filtration rate. Gallium-68 ((68)Ga) EDTA PET usage predates Technetium-99m ((99m)Tc) renal imaging, but virtually disappeared with the widespread adoption of gamma camera technology that was not optimal for imaging positron decay. There is now a reemergence of interest in (68)Ga owing to the greater availability of PET technology and use of (68)Ga to label other radiotracers. (68)Ga EDTA can be used a substitute for (99m)Tc DTPA for wide variety of clinical indications. A key advantage of PET for renal imaging over conventional scintigraphy is 3-dimensional dynamic imaging, which is particularly helpful in patients with complex anatomy in whom planar imaging may be nondiagnostic or difficult to interpret owing to overlying structures containing radioactive urine that cannot be differentiated. Other advantages include accurate and absolute (rather than relative) camera-based quantification, superior spatial and temporal resolution and integrated multislice CT providing anatomical correlation. Furthermore, the (68)Ga generator enables on-demand production at low cost, with no additional patient radiation exposure compared with conventional scintigraphy. Over the past decade, we have employed (68)Ga EDTA PET/CT primarily to answer difficult clinical questions in patients in whom other modalities have failed, particularly when it was envisaged that dynamic 3D imaging would be of assistance. We have also used it as a substitute for (99m)Tc DTPA if unavailable owing to supply issues, and have additionally examined the role of

  7. Initial tests of a prototype MRI-compatible PET imager

    Science.gov (United States)

    Raylman, Raymond R.; Majewski, Stan; Lemieux, Susan; Velan, S. Sendhil; Kross, Brain; Popov, Vladimir; Smith, Mark F.; Weisenberger, Andrew G.; Wojcik, Randy

    2006-12-01

    Multi-modality imaging is rapidly becoming a valuable tool in the diagnosis of disease and in the development of new drugs. Functional images produced with PET fused with anatomical structure images created by MRI, will allow the correlation of form with function. Our group (a collaboration of West Virginia University and Jefferson Lab) is developing a system to acquire MRI and PET images contemporaneously. The prototype device consists of two opposed detector heads, operating in coincidence mode with an active FOV of 5×5×4 cm 3. Each MRI-PET detector module consists of an array of LSO detector elements (2.5×2.5×15 mm 3) coupled through a long fiber optic light guide to a single Hamamatsu flat panel PSPMT. The fiber optic light guide is made of a glued assembly of 2 mm diameter acrylic fibers with a total length of 2.5 m. The use of a light guides allows the PSPMTs to be positioned outside the bore of the 3 T General Electric MRI scanner used in the tests. Photon attenuation in the light guides resulted in an energy resolution of ˜60% FWHM, interaction of the magnetic field with PSPMT further reduced energy resolution to ˜85% FWHM. Despite this effect, excellent multi-plane PET and MRI images of a simple disk phantom were acquired simultaneously. Future work includes improved light guides, optimized magnetic shielding for the PSPMTs, construction of specialized coils to permit high-resolution MRI imaging, and use of the system to perform simultaneous PET and MRI or MR-spectroscopy .

  8. Initial tests of a prototype MRI-compatible PET imager

    Energy Technology Data Exchange (ETDEWEB)

    Raylman, Raymond R. [Center for Advanced Imaging, Department of Radiology, West Virginia University, HSB Box 9236, Morgantown, WV (United States)]. E-mail: rraylman@wvu.edu; Majewski, Stan [Detector Group, Physics Division, Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Lemieux, Susan [Center for Advanced Imaging, Department of Radiology, West Virginia University, HSB Box 9236, Morgantown, WV (United States); Velan, S. Sendhil [Center for Advanced Imaging, Department of Radiology, West Virginia University, HSB Box 9236, Morgantown, WV (United States); Kross, Brain [Detector Group, Physics Division, Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Popov, Vladimir [Detector Group, Physics Division, Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Smith, Mark F. [Detector Group, Physics Division, Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Weisenberger, Andrew G. [Detector Group, Physics Division, Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Wojcik, Randy [Detector Group, Physics Division, Thomas Jefferson National Accelerator Facility, Newport News, VA (United States)

    2006-12-20

    Multi-modality imaging is rapidly becoming a valuable tool in the diagnosis of disease and in the development of new drugs. Functional images produced with PET fused with anatomical structure images created by MRI, will allow the correlation of form with function. Our group (a collaboration of West Virginia University and Jefferson Lab) is developing a system to acquire MRI and PET images contemporaneously. The prototype device consists of two opposed detector heads, operating in coincidence mode with an active FOV of 5x5x4 cm{sup 3}. Each MRI-PET detector module consists of an array of LSO detector elements (2.5x2.5x15 mm{sup 3}) coupled through a long fiber optic light guide to a single Hamamatsu flat panel PSPMT. The fiber optic light guide is made of a glued assembly of 2 mm diameter acrylic fibers with a total length of 2.5 m. The use of a light guides allows the PSPMTs to be positioned outside the bore of the 3 T General Electric MRI scanner used in the tests. Photon attenuation in the light guides resulted in an energy resolution of {approx}60% FWHM, interaction of the magnetic field with PSPMT further reduced energy resolution to {approx}85% FWHM. Despite this effect, excellent multi-plane PET and MRI images of a simple disk phantom were acquired simultaneously. Future work includes improved light guides, optimized magnetic shielding for the PSPMTs, construction of specialized coils to permit high-resolution MRI imaging, and use of the system to perform simultaneous PET and MRI or MR-spectroscopy.

  9. Advances in time-of-flight PET.

    Science.gov (United States)

    Surti, Suleman; Karp, Joel S

    2016-01-01

    This paper provides a review and an update on time-of-flight PET imaging with a focus on PET instrumentation, ranging from hardware design to software algorithms. We first present a short introduction to PET, followed by a description of TOF PET imaging and its history from the early days. Next, we introduce the current state-of-art in TOF PET technology and briefly summarize the benefits of TOF PET imaging. This is followed by a discussion of the various technological advancements in hardware (scintillators, photo-sensors, electronics) and software (image reconstruction) that have led to the current widespread use of TOF PET technology, and future developments that have the potential for further improvements in the TOF imaging performance. We conclude with a discussion of some new research areas that have opened up in PET imaging as a result of having good system timing resolution, ranging from new algorithms for attenuation correction, through efficient system calibration techniques, to potential for new PET system designs.

  10. Advances in time-of-flight PET

    Science.gov (United States)

    Surti, Suleman; Karp, Joel S.

    2016-01-01

    This paper provides a review and an update on time-of-flight PET imaging with a focus on PET instrumentation, ranging from hardware design to software algorithms. We first present a short introduction to PET, followed by a description of TOF PET imaging and its history from the early days. Next, we introduce the current state-of-art in TOF PET technology and briefly summarize the benefits of TOF PET imaging. This is followed by a discussion of the various technological advancements in hardware (scintillators, photo-sensors, electronics) and software (image reconstruction) that have led to the current widespread use of TOF PET technology, and future developments that have the potential for further improvements in the TOF imaging performance. We conclude with a discussion of some new research areas that have opened up in PET imaging as a result of having good system timing resolution, ranging from new algorithms for attenuation correction, through efficient system calibration techniques, to potential for new PET system designs. PMID:26778577

  11. Fabrication and validation of the prototype supporting system for the CLIC Two-Beam modules

    CERN Document Server

    Gazis, N; Griffet, S; Samoshkin, A

    2011-01-01

    The micron-precision RF structures are mounted and aligned on specially developed supporting girders, which provide stability and re-positioning. The supporting girders have stiffness and damping specifications imposed by stringent beam physics and RF requirements. In addition, several constraints, such as allocated space and weight limitation have to be taken into consideration. This paper describes different support concepts following various fabrication techniques and materials. Extensive qualification measurements have been performed on the first prototype units, and the main results are also reported.

  12. FABRICATION AND VALIDATION OF THE PROTOTYPE SUPPORTING SYSTEM FOR THE CLIC TWO-BEAM MODULES

    CERN Document Server

    Gazis, N; Griffet, S; Samoshkin, A

    2011-01-01

    The micron-precision RF structures are mounted and aligned on specially developed supporting girders, which provide stability and re-positioning. The supporting girders have stiffness and damping specifications imposed by stringent beam physics and RF requirements. In addition, several constraints, such as allocated space and weight limitation have to be taken into consideration. This paper describes different support concepts following various fabrication techniques and materials. Extensive qualification measurements have been performed on the first prototype units, and the main results are also reported.

  13. Wild birds as pets in Campina Grande, Paraíba State, Brazil: an ethnozoological approach.

    Science.gov (United States)

    Licarião, Morgana R; Bezerra, Dandara M M; Alves, Rômulo R N

    2013-03-01

    Birds are one of the animals most widely used by humans and are highly valued as pets. The present work reports the use of wild birds as pets in the city of Campina Grande, Paraíba State (PB), Brazil. The owners' choice and perceptions of the species ecology was assessed as well. The methodology employed included unstructured and semi-structured interviews, guided tours and direct observations. A total of 26 bird species distributed among ten families and four orders were identified. The most frequently encountered order was Passeriformes (76.9%), with a predominance of the family Emberizidae (34.6%). The specimens kept as pets were principally obtained in public markets or between the breeders themselves. The popularity of birds as pets, compounded by the inefficiency of official controls over the commerce of wild animals has stimulated the illegal capture and breeding of wild birds in Campina Grande.

  14. [Technical limits of PET/CT with 18FDG in prostate cancer].

    Science.gov (United States)

    von Mallek, D; Backhaus, B; Müller, S C; Matthies, A; Palmedo, H; Jaeger, U; Biersack, H-J; Reinhardt, M

    2006-05-01

    There is increasing evidence that (18)FDG-PET is not useful for the imaging of primary prostate cancer. The aim of this examination was to prove whether or not these poor results are due to technical deficiencies of the examination method like older image reconstruction techniques, extensive (18)FDG-tracer activity in the bladder or improper contrast staining of the rectum. We examined three patients with primary prostate cancer using a modern combined PET/CT system, continuous irrigation of the bladder and an air-inflated rectal balloon catheter. PET/CT images show an exact depiction of both the prostate and all surrounding anatomic structures but no enhanced uptake of radiotracer in the tumour. Therefore, the mentioned poor results of (18)FDG-PET seem not to be due to technical deficiencies.

  15. Current status and future role of brain PET/MRI in clinical and research settings

    Energy Technology Data Exchange (ETDEWEB)

    Werner, P.; Barthel, H.; Sabri, O. [University Hospital Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Drzezga, A. [University Hospital Cologne, Department of Nuclear Medicine, Koeln (Germany)

    2015-01-09

    Hybrid PET/MRI systematically offers a complementary combination of two modalities that has often proven itself superior to the single modality approach in the diagnostic work-up of many neurological and psychiatric diseases. Emerging PET tracers, technical advances in multiparametric MRI and obvious workflow advantages may lead to a significant improvement in the diagnosis of dementia disorders, neurooncological diseases, epilepsy and neurovascular diseases using PET/MRI. Moreover, simultaneous PET/MRI is well suited to complex studies of brain function in which fast fluctuations of brain signals (e.g. related to task processing or in response to pharmacological interventions) need to be monitored on multiple levels. Initial simultaneous studies have already demonstrated that these complementary measures of brain function can provide new insights into the functional and structural organization of the brain. (orig.)

  16. Development of high shrinkage polyethylene terephthalate (PET) shape memory polymer tendons for concrete crack closure

    Science.gov (United States)

    Teall, Oliver; Pilegis, Martins; Sweeney, John; Gough, Tim; Thompson, Glen; Jefferson, Anthony; Lark, Robert; Gardner, Diane

    2017-04-01

    The shrinkage force exerted by restrained shape memory polymers (SMPs) can potentially be used to close cracks in structural concrete. This paper describes the physical processing and experimental work undertaken to develop high shrinkage die-drawn polyethylene terephthalate (PET) SMP tendons for use within a crack closure system. The extrusion and die-drawing procedure used to manufacture a series of PET tendon samples is described. The results from a set of restrained shrinkage tests, undertaken at differing activation temperatures, are also presented along with the mechanical properties of the most promising samples. The stress developed within the tendons is found to be related to the activation temperature, the cross-sectional area and to the draw rate used during manufacture. Comparisons with commercially-available PET strip samples used in previous research are made, demonstrating an increase in restrained shrinkage stress by a factor of two for manufactured PET filament samples.

  17. Influence of expanded graphite (EG and graphene oxide (GO on physical properties of PET based nanocomposites

    Directory of Open Access Journals (Sweden)

    Paszkiewicz Sandra

    2014-12-01

    Full Text Available This work is the continuation and refinement of already published communications based on PET/EG nanocomposites prepared by in situ polymerization1, 2. In this study, nanocomposites based on poly(ethylene terephthalate with expanded graphite were compared to those with functionalized graphite sheets (GO. The results suggest that the degree of dispersion of nanoparticles in the PET matrix has important effect on the structure and physical properties of the nanocomposites. The existence of graphene sheets nanoparticles enhances the crystallization rate of PET. It has been confirmed that in situ polymerization is the effective method for preparation nanocomposites which can avoid the agglomeration of nanoparticles in polymer matrices and improve the interfacial interaction between nanofiller and polymer matrix. The obtained results have shown also that due to the presence of functional groups on GO surface the interactions with PET matrix can be stronger than in the case of exfoliated graphene (EG and matrix.

  18. Regional quantitative analysis of cortical surface maps of FDG PET images

    CERN Document Server

    Protas, H D; Hayashi, K M; Chin Lung, Yu; Bergsneider, M; Sung Cheng, Huang

    2006-01-01

    Cortical surface maps are advantageous for visualizing the 3D profile of cortical gray matter development and atrophy, and for integrating structural and functional images. In addition, cortical surface maps for PET data, when analyzed in conjunction with structural MRI data allow us to investigate, and correct for, partial volume effects. Here we compared quantitative regional PET values based on a 3D cortical surface modeling approach with values obtained directly from the 3D FDG PET images in various atlas-defined regions of interest (ROIs; temporal, parietal, frontal, and occipital lobes). FDG PET and 3D MR (SPGR) images were obtained and aligned to ICBM space for 15 normal subjects. Each image was further elastically warped in 2D parameter space of the cortical surface, to align major cortical sulci. For each point within a 15 mm distance of the cortex, the value of the PET intensity was averaged to give a cortical surface map of FDG uptake. The average PET values on the cortical surface map were calcula...

  19. Positron sources for electron-positron colliders application to the ILC and CLIC

    CERN Document Server

    CERN. Geneva

    2008-01-01

    The increased demanding qualities for positron sources dedicated to e+e- colliders pushed on investigations oriented on new kinds of e+ sources. The different kinds of positron sources polarized and no polarized are considered. Their main features (intensity, emittance) are described and analysed. Comparison between the different sources is worked out. The characteristics of the positron beam available in the collision point are greatly depending on the capture device and on the positron accelerator. Different kinds of capture systems are considered and their qualities, compared. Intense positron sources which are necessary for the colliders require intense incident beams (electrons or photons). The large number of pairs created in the targets leads to important energy deposition and so, thermal heating, which associated to temperature gradients provoke mechanical stresses often destructive. Moreover, the important Coulomb collisions, can affect the atomic structure in crystal targets and the radiation resist...

  20. A sensitiviy analysis for the stabilization of the CLIC main beam quadrupoles

    CERN Document Server

    Janssens, S; Artoos, K; Fernandez Carmona, P; Hauviller, C

    2010-01-01

    In particle colliders (like the LHC), particles are highly accelerated in a circular beam pipe before the collision. However, due to the curved trajectory of the particles, they are also loosing energy because of the so-called Bremsstrahlung. In order to bypass this fundamental limitation imposed by circular beams, the next generation of particle colliders will accelerate two straight beams of particles before the collision. One of them, the Compact Linear Collider, is currently under study at CERN. The machine is constituted of a huge number of accelerating structures (used to accelerate the particles) and quadrupoles (electromagnets used to focus the particles). The latter ones are required to be stable at the nanometer level. This extreme stability has to be guaranteed by active vibration isolation from all types of disturbances like ground vibrations, ventilation, cooling system, or acoustic noise. Because of the huge number of quadrupoles (about 4000), it is critical that the strategy adopted for the act...