WorldWideScience

Sample records for cleared cber 510k

  1. CBERS-02 Application Assessment

    Institute of Scientific and Technical Information of China (English)

    GUO Jianning; YU Jin; MIN Xiangjun; LI Xingchao; HOU Minghui

    2004-01-01

    As the successor of CBERS-01, CBERS-02 was launched successfully on 21October 2003 and transmitted its first downlink data the next day. According to the OBT (On Board Test) outline, CRESDA cooperated with CAST and many remote sensing organizations in China in implementing the test of the satellite payloads, ground processing system and data application. In this paper, the test is briefly illustrated in three parts: Ⅰ. Satellite Parameters Test (especially the test for payloads), Ⅱ. Payload Image Quality Assessment, and Ⅲ. Data Application Assessment. The results of the test show that the image quality of CBERS-02 is much improved over CBERS-01 and will continue to play a more important role in the society and economic development of China.

  2. Center for Biologics Evaluation and Research (CBER)

    Data.gov (United States)

    Federal Laboratory Consortium — CBER is the Center within FDA that regulates biological products for human use under applicable federal laws, including the Public Health Service Act and the Federal...

  3. The Prototype Development for The Second Generation CBERS Initiates

    Institute of Scientific and Technical Information of China (English)

    SunQing

    2005-01-01

    It's reported that the concept for the second generation CBERS-CBERS-03 & 04 to be jointly developed by China Academy of Space Technology (CAST) and INPE went through the assessment by China Aerospace Science and Technology Corporation (CASC) at the beginning of the year. It means that the prototype development of CBERS-03 & 04 has been initiated.

  4. Applications Of CBERS Data In Oceanic Research

    Institute of Scientific and Technical Information of China (English)

    Li Xiaomin; Zhang Jie; Ma Yi; Song Pingjian

    2009-01-01

    @@ The CBERS series satellite data has been widely used by the First Institute of Oceanography, State Oceanic Administration (SOA) for the studies related to the monitoring of coral islands, land use changes of islands and coastal zone, green tide,implementation of ocean functional zoning, suspended particulate matter,sea ice, rafts cultivation and so on.The data covers the range of islands,coastal zone and inshore sea areas.

  5. The Application Achievements And Perspective Of CBERS Series Satellite Imagery

    Institute of Scientific and Technical Information of China (English)

    Li Xingchao; Qi Xueyong; Lu Yilin

    2009-01-01

    @@ Since the first China-Brazil Earth Resources Satellite (CBERS-1),launched in 1999,the CBERS data has been applied in many fields extensively.Remarkable social and economic benefits have been achieved.This article presents the application achievements during the past nine years,and gives a perspective for the future.All these applications demonstrate that the CBERS data has been an important data source for resources investigation and monitoring.

  6. 75 FR 4402 - Strengthening the Center for Devices and Radiological Health's 510(k) Review Process; Public...

    Science.gov (United States)

    2010-01-27

    ... requirement), that the device meets the comparative standard of ``substantial equivalence'' to a ``predicate... are safe and effective, and to promote innovation in the medical device industry. The 510(k) premarket... different ``intended uses'' and explain your reasoning. b. What are the advantages and disadvantages...

  7. 76 FR 45825 - Center for Devices and Radiological Health 510(k) Clearance Process; Institute of Medicine Report...

    Science.gov (United States)

    2011-08-01

    ... Process; Institute of Medicine Report: ``Medical Devices and the Public's Health, The FDA 510(k) Clearance... Medicine (IOM) report entitled: ``Medical Devices and the Public's Health, The FDA 510(k) Clearance Process.... ADDRESSES: See the SUPPLEMENTARY INFORMATION section for electronic access to the document....

  8. Atmospheric correction of CBERS CCD images with MODIS data

    Institute of Scientific and Technical Information of China (English)

    LI; Junsheng; ZHANG; Bing; CHEN; Zhengchao; SHEN; Qian

    2006-01-01

    China Brazil Earth Resource Satellite (CBERS) CCD images have much potential for inland water environmental monitoring. However, their atmospheric accuracy correction can affect their quantitative applications. This paper contains an atmospheric correction algorithm for CBERS CCD images with MODIS data from the same day, the use of which improves the atmospheric correction algorithm of ocean color remote sensing developed by Gordon (1993, 1994) and makes it applicable to inland waters. The improved algorithm retrieves atmospheric parameters from MODIS data and uses them to perform the atmospheric correction of CBERS CCD images. Experimental results show that the atmospheric correction algorithm of CBERS CCD images assisted by MODIS data is reliable. Furthermore, MODIS data can be freely obtained on a daily basis, making the algorithm developed in this paper useful for environmental monitoring of inland waters.

  9. CBERS-2B Monitored Forest Fires In Yunnan Province

    Institute of Scientific and Technical Information of China (English)

    Rain.L

    2008-01-01

    @@ Several forest fires hit Yunnan Province,in the southwest of China from April 6 to 9.Two disastrous fires happened near Shangri-La County,Yunnan Province.According to the requirement of the Land and Surveying Department of Yunnan Province,the China Center for Resources Satellite Data & Application (CRESDA) provided satellite monitoring images to detect the events.The processed CBERS-2B images were delivered to the related departments for decision making and disaster relief.

  10. 78 FR 100 - Guidance for Industry and Food and Drug Administration Staff; Refuse To Accept Policy for 510(k)s...

    Science.gov (United States)

    2013-01-02

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry and Food and Drug Administration Staff; Refuse To Accept Policy for 510(k)s; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of the...

  11. CRESDA APPLICATION SYSTEM OF CBERS-1, RESULTS AND TYPICAL EXAMPLES OF APPLICATIONS

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    CRESDA Application System of CBERS-1 was established in 1999. During the operation of the system for more than two years, about 240 000 scenes of CBERS-1 Level 0 data have been archived and more than 13 000 scenes of Level 2 products have been ordered by end users from different application fields.In this paper, the typical examples of applications in crop yield estimation,calamity alleviation, resources survey and protection, environment monitoring and continuable development, and urban planning are mainly described.

  12. Discriminação de variedades de citros em imagens CCD/CBERS-2 Discrimination of citrus varieties using CCD/CBERS-2 satellite imagery

    Directory of Open Access Journals (Sweden)

    Ieda Del'Arco Sanches

    2008-02-01

    Full Text Available O presente trabalho teve o objetivo de avaliar as imagens CCD/CBERS-2 quanto à possibilidade de discriminarem variedades de citros. A área de estudo localiza-se em Itirapina (SP e, para este estudo, foram utilizadas imagens CCD de três datas (30/05/2004, 16/08/2004 e 11/09/2004. Um modelo que integra os elementos componentes da cena citrícola sensoriada é proposto com o objetivo de explicar a variabilidade das respostas das parcelas de citros em imagens orbitais do tipo CCD/CBERS-2. Foram feitas classificações pelos algoritmos Isoseg e Maxver e, de acordo com o índice kappa, concluiu-se que é possível obterem-se exatidões qualificadas como muito boas, sendo que as melhores classificações foram conseguidas com imagens da estação seca.This paper was aimed at evaluating the possibility of discriminating citrus varieties in CCD imageries from CBERS-2 satellite ("China-Brazil Earth Resouces Satellite". The study area is located in Itirapina, São Paulo State. For this study, three CCD images from 2004 were acquired (May 30, August 16, and September 11. In order to acquire a better understanding and for explaining the variability of the spectral behavior of the citrus areas in orbital images (like as the CCD/CBERS-2 images a model that integrates the elements of the citrus scene is proposed and discussed. The images were classified by Isoseg and MaxVer classifiers. According to kappa index, it was possible to obtain classifications qualified as 'very good'. The best results were obtained with the images from the dry season.

  13. Pre-Launch Absolute Calibration of CCD/CBERS-2B Sensor

    Science.gov (United States)

    Ponzoni, Flávio Jorge; Albuquerque, Bráulio Fonseca Carneiro

    2008-01-01

    Pre-launch absolute calibration coefficients for the CCD/CBERS-2B sensor have been calculated from radiometric measurements performed in a satellite integration and test hall in the Chinese Academy of Space Technology (CAST) headquarters, located in Beijing, China. An illuminated integrating sphere was positioned in the test hall facilities to allow the CCD/CBERS-2B imagery of the entire sphere aperture. Calibration images were recorded and a relative calibration procedure adopted exclusively in Brazil was applied to equalize the detectors responses. Averages of digital numbers (DN) from these images were determined and correlated to their respective radiance levels in order to calculate the absolute calibration coefficients. It has been the first time these pre-launch absolute calibration coefficients have been calculated considering the Brazilian image processing criteria. Now it will be possible to compare them to those that will be calculated from vicarious calibration campaigns. This comparison will permit the CCD/CBERS-2B monitoring and the frequently data updating to the user community. PMID:27873886

  14. Direct Determination of the Rate Coefficient for the Reaction of OH Radicals with Monoethanol Amine (MEA) from 296 to 510 K.

    Science.gov (United States)

    Onel, L; Blitz, M A; Seakins, P W

    2012-04-05

    Monoethanol amine (H2NCH2CH2OH, MEA) has been proposed for large-scale use in carbon capture and storage. We present the first absolute, temperature-dependent determination of the rate coefficient for the reaction of OH with MEA using laser flash photolysis for OH generation, monitoring OH removal by laser-induced fluorescence. The room-temperature rate coefficient is determined to be (7.61 ± 0.76) × 10(-11) cm(3) molecule(-1) s(-1), and the rate coefficient decreases by about 40% by 510 K. The temperature dependence of the rate coefficient is given by k1= (7.73 ± 0.24) × 10(-11)(T/295)(-(0.79±0.11)) cm(3) molecule(-1) s(-1). The high rate coefficient shows that gas-phase processing in the atmosphere will be competitive with uptake onto aerosols.

  15. CBERS-2B Brazilian remote sensing satellite to help to monitor the Bolivia-Brazil gas pipeline

    Energy Technology Data Exchange (ETDEWEB)

    Hernandes, Gilberto Luis Sanches [TBG Transportadora Brasileira Gasoduto Bolivia-Brasil, Rio de Janeiro, RJ (Brazil)

    2009-07-01

    This paper presents the results of CBERS-2B' Brazilian Remote Sensing Satellite to help to monitor the Bolivia-Brazil Gas Pipeline. The CBERS-2B is the third satellite launched in 2007 by the CBERS Program (China-Brazil Earth Resources Satellite) and the innovation was the HRC camera that produces high resolution images. It will be possible to obtain one complete coverage of the country every 130 days. In this study, 2 images from different parts of the Bolivia- Brazil Gas Pipeline were selected. Image processing involved the geometric registration of CBERS-2B satellite images with airborne images, contrast stretch transform and pseudo color. The analysis of satellite and airborne images in a GIS software to detect third party encroachment was effective to detect native vegetation removal, street construction, growth of urban areas, farming and residential/industrial land development. Very young, the CBERS-2B is a good promise to help to inspect the areas along the pipelines. (author)

  16. Features information extraction of the mining area based on CBERS-02B%基于CBERS-02B的矿区地物信息的提取

    Institute of Scientific and Technical Information of China (English)

    王飞红; 任晓敏

    2013-01-01

    Object-oriented classification method is used to extract information from the Pingshuo surface coal mine in Shanxi Province. China-Brazil Earth Resources Satel ite(CBERS-02B)is used as data sources.The multi-scale segmentation and partitions level are created by object-oriented classification method.Through comparison of different segmentation results,the final segmentation scales are obtained.And spectral and spatial characteristics of the specific surface features are used to classify the image into vegetation, roads,mine construction,coal pile,mining face,waste rock dumps through the fuzzy classification of the membership function classification method.In the end,The classification result is evaluated by the error matrix,the result shows that the overal classification accuracy reaches 88.03%,and Kappa coefficient is 0.88.%应用面向对象分类方法,对山西省平朔露天煤矿进行信息提取。以中巴资源卫星CBERS-02B卫星遥感影像为数据源,利用面向对象分类方法进行多尺度分割并建立分割等级,通过对不同分割尺度的分割结果进行比较,获得最终分割尺度,并结合具体地物的光谱、空间等特征,采用模糊分类中的隶属度函数分类方法,最终将地物分为植被、道路、矿区建筑、煤堆、开采面、废石堆六类。最后使用误差矩阵对分类结果进行精度评价,其总体分类精度达到了88.63%,Kappa系数为0.89。

  17. Assessing the Relative Ecological Importance and Deforestation Risks of Unprotected Areas in Western Brazil Using Landsat, CBERS and Quantum GIS

    Science.gov (United States)

    Smith, A.; Sevilla, C.; Lanclos, A.; Carson, C.; Larson, J.; Sankaran, M.; Saad, M.

    2012-12-01

    In addition to understanding Brazilian policies and currently utilized methodologies, the measurement of the impacts of deforestation is essential for enhancing techniques to reduce deforestation in the future. Adverse impacts of deforestation include biodiversity loss, increased carbon dioxide emissions, and a reduced rate of evapotranspiration, all of which contribute directly or indirectly to global warming. With the continual growth in population in developing countries such as Brazil, increased demands are placed on infrastructural development and food production. As a result, forested areas are cleared for agricultural production. Recently, exploration for hydrocarbons in Western Brazil has also intensified as a means to stimulate the economy, as abundant oil and gas is believed to be found in these regions. Unfortunately, hydrocarbon-rich regions of Western Brazil are also home to thousands of species. Many of these regions are as of yet untapped but are at risk of ecological disruption as a result of impending human activity. This project utilized Landsat 5 TM to monitor deforestation in a subsection of the Brazilian states of Rondônia and Amazonas. A risk map identifying areas susceptible to future deforestation, based on factors such as proximity to roads, bodies of water, cities, and proposed hydrocarbon activities such as pipeline construction, was created. Areas at higher risk of clearance were recommended to be a target for enhanced monitoring and law enforcement. In addition, an importance map was created based on biodiversity and location of endangered species. This map was used to identify potential areas for future protection. A Chinese-Brazilian satellite, CBERS 2B CCD was also utilized for comparison. The NDVI model was additionally replicated in Quantum GIS, an open source software, so that local communities and policymakers could benefit without having to pay for expensive ArcGIS software. The capabilities of VIIRS were also investigated to

  18. Classification of CBERS-2 Imagery with Fuzzy ARTMAP Classifier%用模糊ARTMAP算法对中巴卫星02数据进行分类

    Institute of Scientific and Technical Information of China (English)

    骆成凤; 刘正军; 燕琴

    2007-01-01

    A fuzzy ARTMAP classifier is adopted for a classification experiment of CBERS-2 imagery. The fundamental theory and processing about the algorithm are first introduced, followed with a land-use classification experiment in Shihezi County on CBERS-2 high resolution imagery. Three classifiers are compared: maximum likelihood classifier (MLC), error back propagation (BP) classifier, and fuzzy ARTMAP classifier. The comparison shows comparably better results for the fuzzy ARTMAP classifier, with overall classification accuracy of 9.9% and 4.6% higher than that of MLC and BP. The results also prove that the fuzzy ARTMAP classifier has better discernment in identifying bare soil on CBERS-2 imagery.

  19. The investigation of special information distilling method of land use in karst area based on CBERS-02B and analysis on application: a case study of Duyun, Guizhou

    Science.gov (United States)

    Hu, Juan; Luo, Miao; An, Yulun

    2010-09-01

    This paper explores the optimal methods for processing CBERS-02B images and using them to classify the land uses of karst mountain areas with 3S technologies, especially the RS digital image processing technology. Through multiple experiments and analysis, the difficulty of CBERS-02B images in distinguishing water from mountain shades, construction land from dry land and paddy field are satisfactorily removed. And the combination of band 421, based on OIF method, is proved optimal for classifying the land uses of karst areas. After comparing and evaluating the effect of HIS, PCA and HPC based image fusion methods, the HIS transformation based image fusion method is found best for CBERS-02B HR and CCD data fusion in the case of karst highland mountains. Based on the experiments, this paper proves that CBERS images are capable of large scale land use classification for karst areas, a competent substitute of TM images for karst mountain area land use survey.

  20. Clear & Simple

    Science.gov (United States)

    ... Cultural Respect Language Access Talking to Your Doctor Research Underway Plain Language Clear & Simple What is Clear & Simple? Clear & Simple ... schedule? A: Pretesting need not be an elaborate, time-consuming research project and depends on: How quickly you work, ...

  1. STRIPING NOISE REMOVAL OF IMAGES ACQUIRED BY CBERS 2 CCD CAMERA SENSOR

    Directory of Open Access Journals (Sweden)

    E. Amraei

    2014-10-01

    Full Text Available CCD Camera is a multi-spectral sensor that is carried by CBERS 2 satellite. Imaging technique in this sensor is push broom. In images acquired by the CCD Camera, some vertical striping noise can be seen. This is due to the detectors mismatch, inter detector variability, improper calibration of detectors and low signal-to-noise ratio. These noises are more profound in images acquired from the homogeneous surfaces, which are processed at level 2. However, the existence of these noises render the interpretation of the data and extracting information from these images difficult. In this work, spatial moment matching method is proposed to modify these images. In this method, the statistical moments such as mean and standard deviation of columns in each band are used to balance the statistical specifications of the detector array to those of reference values. After the removal of the noise, some periodic diagonal stripes remain in the image where their removal by using the aforementioned method seems impossible. Therefore, to omit them, frequency domain Butterworth notch filter was applied. Finally to evaluate the results, the image statistical moments such as the mean and standard deviation were deployed. The study proves the effectiveness of the method in noise removal.

  2. Energetic particle radiations measured by particle detector on board CBERS-1 satellite

    Institute of Scientific and Technical Information of China (English)

    HAO YongQiang; XIAO Zuo; ZOU Hong; ZHANG DongHe

    2007-01-01

    Using the data measured by energetic particle detector on board CBERS-01 and -02 for the past five years, statistics was made to show the general features of MeV electrons and protons along a solar synchronous orbit at an altitude of 780 km. This height is in the bottom region of the Earth's radiation belts. Detectors are inside the satellite cabinet and such continuous monitoring of particle radiation environment inside a satellite has seldom conducted so far. After a proper and careful treatment, it is indicated that the data inside satellite are well correlated with the radiation environment outside. Besides the agreement of the general distribution characteristics of energetic electrons and protons with similar observations from other satellites, attention is particularly paid to the disturbed conditions. Variations of particle fluxes are closely related with solar proton events, in general, electron fluxes of outer belt are well correlated with Dst index after three days' delay while the electron injection occurred almost at the same day during great magnetic storms. It is confirmed that both energetic electrons and protons appear in the Polar Cap region only after the solar proton events.

  3. Land use mapping from CBERS-2 images with open source tools by applying different classification algorithms

    Science.gov (United States)

    Sanhouse-García, Antonio J.; Rangel-Peraza, Jesús Gabriel; Bustos-Terrones, Yaneth; García-Ferrer, Alfonso; Mesas-Carrascosa, Francisco J.

    2016-02-01

    Land cover classification is often based on different characteristics between their classes, but with great homogeneity within each one of them. This cover is obtained through field work or by mean of processing satellite images. Field work involves high costs; therefore, digital image processing techniques have become an important alternative to perform this task. However, in some developing countries and particularly in Casacoima municipality in Venezuela, there is a lack of geographic information systems due to the lack of updated information and high costs in software license acquisition. This research proposes a low cost methodology to develop thematic mapping of local land use and types of coverage in areas with scarce resources. Thematic mapping was developed from CBERS-2 images and spatial information available on the network using open source tools. The supervised classification method per pixel and per region was applied using different classification algorithms and comparing them among themselves. Classification method per pixel was based on Maxver algorithms (maximum likelihood) and Euclidean distance (minimum distance), while per region classification was based on the Bhattacharya algorithm. Satisfactory results were obtained from per region classification, where overall reliability of 83.93% and kappa index of 0.81% were observed. Maxver algorithm showed a reliability value of 73.36% and kappa index 0.69%, while Euclidean distance obtained values of 67.17% and 0.61% for reliability and kappa index, respectively. It was demonstrated that the proposed methodology was very useful in cartographic processing and updating, which in turn serve as a support to develop management plans and land management. Hence, open source tools showed to be an economically viable alternative not only for forestry organizations, but for the general public, allowing them to develop projects in economically depressed and/or environmentally threatened areas.

  4. Clear retainer

    Directory of Open Access Journals (Sweden)

    Priyakorn Chaimongkol

    2017-01-01

    Full Text Available A clear retainer is a removable retainer that is popular in the present day. Compared with conventional fixed and removable orthodontic retainers, it is a more esthetic, comfortable, and inexpensive appliance. Although several studies have been published about clear retainers, it could be difficult to interpret the results because of the variety of study designs, sample sizes, and research methods. This article is intended to compile the content from previous studies and discuss advantages, disadvantages, fabrication, insertion, and adjustment. Moreover, the effectiveness in maintaining dental position, occlusion, retention protocols, thickness, and survival rate of clear retainers is discussed.

  5. SNOW CLEARING

    CERN Multimedia

    Groupe de Transport/Transport Group

    1999-01-01

    In order to facilitate snow-clearing operations, which commence at 4.30 every morning, drivers of CERN vehicles are kindly requested to group their cars together in the car parks. This will greatly help us in our work. Thank you for your co-operation.Transport Group / ST-HMTel. 72202

  6. CCD CBERS and ASTER data in dasometric characterization of Pinus radiata D. Don (north-western Spain

    Directory of Open Access Journals (Sweden)

    Eva Sevillano-Marco

    2013-03-01

    Full Text Available A Chinese-Brazilian Earth Resources Satellite (CBERS and an Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER scenes coupled with ancillary georeferenced data and field survey were employed to examine the potential of the remote sensing data in stand basal area, volume and aboveground biomass assessment over large areas of Pinus radiata D. Don plantations in Northwestern Spain. Statistical analysis proved that the near infrared band and the shade fraction image showed significant correlation coefficients with all stand variables considered. Predictive models were accordingly selected and utilized to undertake the spatial distribution of stand variables in radiata stands delimited by the National Forestry Map. The study reinforces the potentiality of remote sensing techniques in a cost-effective assessment of forest systems.

  7. Identifying Spatial Units of Human Occupation in the Brazilian Amazon Using Landsat and CBERS Multi-Resolution Imagery

    Directory of Open Access Journals (Sweden)

    Maria Isabel Sobral Escada

    2012-01-01

    Full Text Available Every spatial unit of human occupation is part of a network structuring an extensive process of urbanization in the Amazon territory. Multi-resolution remote sensing data were used to identify and map human presence and activities in the Sustainable Forest District of Cuiabá-Santarém highway (BR-163, west of Pará, Brazil. The limits of spatial units of human occupation were mapped based on digital classification of Landsat-TM5 (Thematic Mapper 5 image (30m spatial resolution. High-spatial-resolution CBERS-HRC (China-Brazil Earth Resources Satellite-High-Resolution Camera images (5 m merged with CBERS-CCD (Charge Coupled Device images (20 m were used to map spatial arrangements inside each populated unit, describing intra-urban characteristics. Fieldwork data validated and refined the classification maps that supported the categorization of the units. A total of 133 spatial units were individualized, comprising population centers as municipal seats, villages and communities, and units of human activities, such as sawmills, farmhouses, landing strips, etc. From the high-resolution analysis, 32 population centers were grouped in four categories, described according to their level of urbanization and spatial organization as: structured, recent, established and dependent on connectivity. This multi-resolution approach provided spatial information about the urbanization process and organization of the territory. It may be extended into other areas or be further used to devise a monitoring system, contributing to the discussion of public policy priorities for sustainable development in the Amazon.

  8. Identificação de fragmentos de floresta nativa, por diferentes intérpretes, com a utilização de imagens landsat e cbers em lavras, MG Identification of small areas of semideciduous forest, by different analysts, in Lavras region, MG, using Landsat and Cbers sattelites images

    Directory of Open Access Journals (Sweden)

    Elizabeth Ferreira

    2005-06-01

    Full Text Available Neste trabalho, as imagens dos satélites Landsat 7 e Cbers 2 foram analisadas com o objetivo de identificar áreas com fragmentos de floresta semidecídua e de avaliar a exatidão da classificação feita por diferentes intérpretes e técnicas de interpretação. O estudo foi realizado em Lavras, MG, utilizando o SIG-SPRING, que possui recursos para realização da classificação digital e visual. Na comparação das diferentes classificações e avaliação da exatidão, foram empregadas as exatidões global, do consumidor, do produtor e o coeficiente Kappa. Pelos resultados, verificou-se que a exatidão global foi maior que 90% e o coeficiente Kappa variou de 50% a 77% nas comparações feitas por diferentes intérpretes, em imagens Landsat e Cbers. Os mapas de fragmentos de vegetação produzidos com base na classificação digital das imagens Cbers e Landsat apresentaram alta porcentagem de áreas comuns e os intérpretes produziram diferentes mapas, porém, aqueles gerados pela imagem Cbers apresentaram a melhor concordância entre as classificações.In this work two images from Landsat 7 and Cbers 2 were analyzed in order to identify small areas of semideciduous forest and to evaluate the classification accuracy made by three different analysts. The study was carried out in Lavras region, MG, using the SPRING GIS with the appropriate functions to jufil the digital classification and visual inspection. The comparisons between the classifications and accuracy assessment procedures employed the overall accuracy, the user's accuracy, the producer's accuracy and the Kappa coefficient. The results showed that the overall accuracy were higher than 90% and the Kappa coefficient ranged from 50% to 77% when the Landsat and Cbers images were compared by different analysts. The fragments vegetation maps made from digital classification of Cbers and Landsat satellites images presented high percentage of common areas and analysts made different maps

  9. Análise de mapas de represas publicados na web usando imagens orbitais CCD/CBERS no estado de Minas Gerais Analysis of dams maps published on the web by using orbital CCD/CBERS images in Minas Gerais State, Brazil

    Directory of Open Access Journals (Sweden)

    Elizabeth Ferreira

    2010-02-01

    Full Text Available Neste trabalho, bancos de dados públicos e gratuitos disponíveis na World Wide Web (WEB foram utilizados para avaliar as áreas das superfícies dos espelhos d'água das represas de Furnas e do Funil, no Estado de Minas Gerais. O objetivo foi comparar as informações obtidas nos bancos da WEB com os valores das áreas calculadas a partir de imagens do sensor CCD a bordo dos satélites CBERS2 e CBERS2B. A área da represa de Furnas obtida a partir das imagens CCD/CBERS2B, ano 2008, foi de 1.138 km², mas nos bancos de dados consultados esta área estava entre 1.182 e 1.503 km². A represa do Funil, construída em 2003, com superfície de espelho d'água de 29,37 km² e uma ilha com área de 1,93 km² não aparecem nos bancos Atlas, Geominas, IGAM e IBGE. Os resultados mostraram algumas discrepâncias nos bancos de dados publicados na WEB, tais como diferenças em áreas e supressão ou extrapolação de limites do espelho d'água. Concluiu-se que, até o momento, os responsáveis por algumas publicações de bancos de dados no Estado de Minas Gerais não tiveram rigor suficiente com as atualizações. As imagens CCD/CBERS, que também são dados públicos disponíveis na WEB, mostraram ser produtos adequados para verificar, atualizar e melhorar as informações publicadas.In this work some public databases from the World Wide Web (WEB were used to find the area of the Furnas and Funil Dams in Minas Gerais State. The purpose of this work was to compare the WEB public databases values and the real values obtained from the CCD camera images on board CBERS2 and CBERS2B satellites. The Furnas Dam area obtained from CCD/ CBERS2B images, in 2008, was 1.138 km², but in the consulted databases this area ranged from 1.182 to 1.503 km². The dam of the Funil, built in 2003, with a water surface of 29.37 km² and an island with 1.93 km² area, did not appear in Atlas, Geominas, IGAM and IBGE databases. The results revealed some problems in the WEB public

  10. Remote Sensing of the EnviSat and Cbers-2B satellites rotation around the centre of mass by photometry

    Science.gov (United States)

    Koshkin, N.; Korobeynikova, E.; Shakun, L.; Strakhova, S.; Tang, Z. H.

    2016-08-01

    During 2013-2015 the photometric observations of the EnviSat satellite, which became space debris after the failure in April 2012 in low Earth orbit, were performed. The rotation pole position and slow change in sidereal rotation period were updated on the basis of analysis of specular glints observed in 222 light curves using reduction of synodic periods. Apparently, there are minor oscillations of the rotation pole near the normal to the orbital plane. The sense of the EnviSat's spinning is opposite to the sense of its orbital rotation. The sidereal period is best approximated by the second-order polynomial: Psid (sec) = 0.000021534 ·T2 + 0.04936003 · T + 121.18195 where T is measured in days from the beginning of 2013. This method being applied to another representative of space debris, namely the Cbers-2B satellite, has shown a similar result: there is not precise solution for the rotation pole either as it undergoes oscillations with various time scale from several hours to several months. In 2014, the spin axis made the 10 ° angle with the normal to the orbital plane while the sense of spinning is direct in this case, i.e. coincides with the sense of orbital rotation. The sidereal period is best approximated by the following expression: Psid (sec) = 0.000029543 ·T2 + 0.08094931 · T + 81.31775 where T is measured in days starting from March 10, 2014. This method allows of controlling slow changes in the spatial orientation of the rotation axis of the satellites in which specular reflection of light from flat faces of the surface is inherent.

  11. Performance evaluation of different classifiers (Isoseg, Bhattacharyya, Maxver e Maxver-ICM, using CCD/CBERS-1 and ETM+/Landsat-7 fused images

    Directory of Open Access Journals (Sweden)

    Wilson Lins de Mello Filho

    2007-06-01

    Full Text Available The aim of this study was to compare the performance of image classifiers (Isoseg, Bhattacharyya, Maxver and Maxver-ICM based on an accuracy analysis (set percentage, area determination and Kappa coefficient, using as ground truth an edited thematic map. For this, pre-processing techniques (atmospheric, geometric and radiometric corrections, contrast enhancement (IHS data fusion and principal component analysis and classification of CCD/CBERS-1 and ETM+/Landsat-7 images were done. Amongst all classifiers tested, Isoseg and Bhattacharyya presented best performance for the studied classes and the study area. It is anticipated that these results are relevant to environmental analyses based on orbital satellite data.

  12. Clear cell chondrosarcoma

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, R.; David, R.; Cierney, G. III

    1985-01-01

    The clinical, radiologic, and histopathologic features of three cases of clear cell chondrosarcoma are described. On radiographs, this rather benign-appearing tumor resembles a chondroblastoma when it occurs at the end of a long bone, and may occasionally show a calcified matrix. However, it has distinctive tumor cells with a centrally placed vesicular nucleus surrounded by clear cytoplasm. The lesion has a low-grade malignancy and is amenable to en bloc surgical resection, which results in a much better prognosis than that of conventional chondrosarcoma.

  13. Snow-clearing operations

    CERN Document Server

    EN Department

    2010-01-01

    To facilitate snow clearing operations, which commence at 4.30 in the morning, all drivers of CERN cars are kindly requested to park them together in groups. This will help us greatly assist us in our work. Thank-you for your help. Transport Group / EN-HE Tel. 72202

  14. Analysis of the observation of particle detector inside ‘CBERS-1’ satellite under solar quiet conditions

    Institute of Scientific and Technical Information of China (English)

    ZOU; Hong; XIAO; Zuo; HAO; Yongqiang; ZOU; Jiqing; ZHU; Wenming; WU; Zhongxiang

    2006-01-01

    Based on the knowledge and related theory of earth's radiation belt, the data chronous orbit were analyzed. It is proved that the observational results are in agreement with the theoretical description of the radiation belt structures. Analysis of more than 3years' data showed clearly that under quiet solar conditions, at a height of about 800 km the energetic particles were mainly located in three regions: northern auroral belt (40°-80°), southern auroral belt (-40°- -80°) and South Atlantic Geomagnetic Anomaly Region (SAA). Actually, this is for the global distribution, at each longitude the latitudinal coverage is much narrower and particles are along the geomagnetic latitude of about ±60°.The species of particles in different regions and their counting rates are different. In SAA,usually both electrons and protons are observed, which should come from inner radiation belt; in polar regions only energetic electrons are observed under the quiet condition,which belongs to the outer radiation belt. The distribution of outer radiation electrons is asymmetrical for longitudes as well as northern and southern polar regions. These asymmetries can be explained with the reflecting altitudes of the mirror points of charged particles at the same L shell.

  15. Clearing the Big Smog

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Beijing is trying to clean up its sky with a new standard for vehicle emissions From March 1,Beijing has imple- mented a new stricter vehicle emission standard that could lead to cleaner air,but also force thousands of cars off the road. StandardⅣ,the latest in a series of measures aimed at clearing the per- sistent smog,will match the current standard of the European Union. All the new light petro vehicles that are on sale in the Beijing market shall

  16. Consciousness CLEARS the mind.

    Science.gov (United States)

    Grossberg, Stephen

    2007-11-01

    A full understanding of consciousness requires that we identify the brain processes from which conscious experiences emerge. What are these processes, and what is their utility in supporting successful adaptive behaviors? Adaptive Resonance Theory (ART) predicted a functional link between processes of Consciousness, Learning, Expectation, Attention, Resonance and Synchrony (CLEARS), including the prediction that "all conscious states are resonant states". This connection clarifies how brain dynamics enable a behaving individual to autonomously adapt in real time to a rapidly changing world. The present article reviews theoretical considerations that predicted these functional links, how they work, and some of the rapidly growing body of behavioral and brain data that have provided support for these predictions. The article also summarizes ART models that predict functional roles for identified cells in laminar thalamocortical circuits, including the six layered neocortical circuits and their interactions with specific primary and higher-order specific thalamic nuclei and nonspecific nuclei. These predictions include explanations of how slow perceptual learning can occur without conscious awareness, and why oscillation frequencies in the lower layers of neocortex are sometimes slower beta oscillations, rather than the higher-frequency gamma oscillations that occur more frequently in superficial cortical layers. ART traces these properties to the existence of intracortical feedback loops, and to reset mechanisms whereby thalamocortical mismatches use circuits such as the one from specific thalamic nuclei to nonspecific thalamic nuclei and then to layer 4 of neocortical areas via layers 1-to-5-to-6-to-4.

  17. Media Language, Clear or Obscure

    DEFF Research Database (Denmark)

    Jakobsen, Bjarne le Fevre; Ejstrup, Michael

    2015-01-01

    Abstract— Be clear, not obscure. One of the four maxims for optimal communication is that it is essential to develop proficiency in being concise and clear. The question is whether this is really a good idea in all contexts. There is some evidence to the contrary. Undoubtedly, we have many contex...... for the survival of free speech....... growth in diversity, means that media need to be very cognizant of the stringency with which they handle the advice to be linguistically clear and concise. The need to pay great attention to situational awareness is highly visible and intrusive. Attention to situational awareness seems to be crucial...

  18. Optical clearing at cellular level

    Science.gov (United States)

    Kinnunen, Matti; Bykov, Alexander V.; Tuorila, Juho; Haapalainen, Tomi; Karmenyan, Artashes V.; Tuchin, Valery V.

    2014-07-01

    Strong light scattering in tissues and blood reduces the usability of many optical techniques. By reducing scattering, optical clearing enables deeper light penetration and improves resolution in several optical imaging applications. We demonstrate the usage of optical tweezers and elastic light scattering to study optical clearing [one of the major mechanisms-matching of refractive indices (RIs)] at the single particle and cell level. We used polystyrene spheres and human red blood cells (RBCs) as samples and glycerol or glucose water solutions as clearing agents. Optical tweezers kept single microspheres and RBCs in place during the measurement of light scattering patterns. The results show that optical clearing reduces the scattering cross section and increases g. Glucose also decreased light scattering from a RBC. Optical clearing affected the anisotropy factor g of 23.25-μm polystyrene spheres, increasing it by 0.5% for an RI change of 2.2% (20% glycerol) and 0.3% for an RI change of 1.1% (13% glucose).

  19. The art of thinking clearly

    CERN Document Server

    Dobelli, Rolf

    2013-01-01

    The Art of Thinking Clearly by world-class thinker and entrepreneur Rolf Dobelli is an eye-opening look at human psychology and reasoning — essential reading for anyone who wants to avoid “cognitive errors” and make better choices in all aspects of their lives. Have you ever: Invested time in something that, with hindsight, just wasn’t worth it? Or continued doing something you knew was bad for you? These are examples of cognitive biases, simple errors we all make in our day-to-day thinking. But by knowing what they are and how to spot them, we can avoid them and make better decisions. Simple, clear, and always surprising, this indispensable book will change the way you think and transform your decision-making—work, at home, every day. It reveals, in 99 short chapters, the most common errors of judgment, and how to avoid them.

  20. Writing clear animal activity proposals.

    Science.gov (United States)

    Pinson, David M

    2011-06-01

    Although IACUC-related topics are frequently discussed in the literature, there is little published information about how to write animal activity proposals. In this article, the author discusses key considerations in the writing and review of animal activity proposals. The author then describes a framework for developing and writing clear animal activity proposals that highlight animal welfare concerns. Though these recommendations are aimed at individuals writing and reviewing research proposals, the framework can be modified for other types of animal activity proposals.

  1. Ion clearing in an ERL

    Science.gov (United States)

    Hoffstaetter, Georg H.; Liepe, Matthias

    2006-02-01

    The rest-gas in the beam-pipe of a particle accelerator is readily ionized by effects like collisions, synchrotron radiation and field emission. Positive ions are attracted to electron beams and create a nonlinear potential in the vicinity of the beam which can lead to beam halo, particle loss, optical errors or transverse and longitudinal instabilities. In an energy recovery linac (ERL) where beam-loss has to be minimal, and where beam positions and emittances have to be very stable in time, these ion effects have to be avoided. Here we investigate three measures of avoiding ion accumulation: (a) A long gap between linac bunch trains that allows ions to drift out of the beam region, a measure regularly applied in linacs; (b) a short ion clearing gap in the beam that leads to a time varying beam potential and produces large excited oscillations of ions around the electron beam, a measure regularly applied in storage rings; (c) Clearing electrodes that create a sufficient voltage to draw ions out of the beam potential, a measure used for DC electron beams and for antiproton beams. For the parameters of the X-ray ERL planned at Cornell University we show that method (a) cannot be applied, method (b) is technically cumbersome, and (c) should be most easily applicable.

  2. Caracterização espectral de áreas de gramíneas forrageiras infectadas com a doença "mela-das-sementes da braquiária" por meio de imagens CCD/CBERS-2 Spectral characterization of forage grasses infected with the disease "mela-das-sementes da braquiária" through CCD/CDBERS -2 images

    Directory of Open Access Journals (Sweden)

    José C. Rosatti

    2006-12-01

    Full Text Available Imagens CCD/CBERS-2, nas bandas espectrais CCD2, CCD3 e CCD4, dos anos de 2004 e 2005, de Mirante do Paranapanema - SP, foram transformadas em reflectância de superfície usando o modelo 5S de correção atmosférica e normalizadas radiometricamente. O objetivo principal foi caracterizar espectralmente áreas de pastagens de Brachiaria brizantha em fase de florescimento, isentas e infectadas com a doença "mela-das-sementes da braquiária", possibilitando a sua detecção por meio da comparação entre os valores de reflectância de superfície denominada de Fator de Reflectância Bidirecional de Superfície (FRBS. Teve-se, também, o objetivo de avaliar a eficácia das imagens CCD/CBERS-2 para a obtenção de respostas espectrais de pastagens. Os dosséis sadios e doentes da Brachiaria brizantha foram identificados por meio da análise dos valores de reflectância e dos dados observados no Índice de Estresse Hídrico Acumulativo Relativo da Cultura (ACWSI obtidos na área de estudo. Os resultados indicaram que as principais diferenças foram a diminuição da reflectância na banda CCD3 e o aumento da reflectância na banda CCD4 nas áreas doentes. A metodologia empregada com o uso de dados do sensor CCD/CBERS-2, associados ao ACWSI, mostrou-se eficaz para discriminar dosséis infectados com a "mela-das-sementes da braquiária".CCD/CBERS-2 images in the spectral bands of CCD2, CCD3 and CCD4 of the years 2004 and 2005, from Mirante do Paranapanema - SP (Brazil, were transformed into surface reflectance images using the 5S atmospheric correction model and radiometrically normalized. The main objective was to spectrally characterize pastures of Brachiaria brizantha in the flowering phase, exempt and infected with the disease "mela-das-sementes da braquiária" making it possible its detection through the comparison among the SBRF - Surface Bidirectional Reflectance Factor values. At the same time, it was aimed to evaluate the effectiveness of the

  3. 17 CFR 39.4 - Procedures for implementing derivatives clearing organization rules and clearing new products.

    Science.gov (United States)

    2010-04-01

    ... derivatives clearing organization rules and clearing new products. 39.4 Section 39.4 Commodity and Securities... implementing derivatives clearing organization rules and clearing new products. (a) Request for approval of... of § 40.6 of this chapter. (c) Acceptance of new products for clearing. (1) A dormant...

  4. Intelligibility of Clear Speech: Effect of Instruction

    Science.gov (United States)

    Lam, Jennifer; Tjaden, Kris

    2013-01-01

    Purpose: The authors investigated how clear speech instructions influence sentence intelligibility. Method: Twelve speakers produced sentences in habitual, clear, hearing impaired, and overenunciate conditions. Stimuli were amplitude normalized and mixed with multitalker babble for orthographic transcription by 40 listeners. The main analysis…

  5. Unusual clear cell variant of epithelioid mesothelioma.

    Science.gov (United States)

    Dessy, E; Falleni, M; Braidotti, P; Del Curto, B; Panigalli, T; Pietra, G G

    2001-12-01

    Clear cell mesothelioma is an extremely rare neoplasm of the pleura, which can easily be mistaken for a metastasis of clear cell carcinoma to the pleura. We report here the histochemical, immunohistochemical, and ultrastructural aspects of a new case of clear cell pleural mesothelioma in a 52-year-old man with no known asbestos exposure. He was admitted to the hospital for recurrent pleural effusion, which was negative for neoplastic cells at the cytologic examination. A partial decortication of the right pleura was performed. The morphologic, immunohistochemical, and ultrastructural features reported for this case are consistent with the diagnosis of clear cell mesothelioma. The differential diagnosis and immunohistochemical features in comparison with other clear cell neoplasms are discussed.

  6. SNOW CLEARING SERVICE WINTER 2001-2002

    CERN Multimedia

    ST-HM Group; Tel. 72202

    2001-01-01

    As usual at this time of the year, the snowing clearing service, which comes under the control of the Transport Group (ST-HM), is preparing for the start of snow-clearing operations (timetable, stand-by service, personnel responsible for driving vehicles and machines, preparation of useful and necessary equipment, work instructions, etc.) in collaboration with the Cleaning Service (ST-TFM) and the Fire Brigade (TIS-FB). The main difficulty for the snow-clearing service is the car parks, which cannot be properly cleared because of the presence of CERN and private vehicles parked there overnight in different parts of the parking areas. The ST-HM Transport Group would therefore like to invite you to park vehicles together in order to facilitate the access of the snow ploughs, thus allowing the car parks to be cleared more efficiently before the personnel arrives for work in the mornings.

  7. High Altitude Clear Air Turbulence Project

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Air Force Flight Dynamics Laboratory conducted the High Altitude Clear Air Turbulence Project in the mid 1960s with the intention of better understanding air...

  8. Clear cell myoepithelial carcinoma ex pleomorphic adenoma

    Directory of Open Access Journals (Sweden)

    Nikhil R Rabade

    2014-01-01

    Full Text Available Pleomorphic adenoma is the most common epithelial neoplasm of lacrimal gland. A clear cell myoepithelial carcinoma arising in the background of pleomorphic adenoma is common in the salivary glands but very rare in the lacrimal glands. We report the case of a 27 year old man whose lacrimal gland pleomorphic adenoma recurred several times over a period of four years and ultimately evolved into a clear cell myoepithelial carcinoma ex pleomorphic adenoma.

  9. CO2 efflux from cleared mangrove peat.

    Directory of Open Access Journals (Sweden)

    Catherine E Lovelock

    Full Text Available BACKGROUND: CO(2 emissions from cleared mangrove areas may be substantial, increasing the costs of continued losses of these ecosystems, particularly in mangroves that have highly organic soils. METHODOLOGY/PRINCIPAL FINDINGS: We measured CO(2 efflux from mangrove soils that had been cleared for up to 20 years on the islands of Twin Cays, Belize. We also disturbed these cleared peat soils to assess what disturbance of soils after clearing may have on CO(2 efflux. CO(2 efflux from soils declines from time of clearing from ∼10,600 tonnes km(-2 year(-1 in the first year to 3000 tonnes km(2 year(-1 after 20 years since clearing. Disturbing peat leads to short term increases in CO(2 efflux (27 umol m(-2 s(-1, but this had returned to baseline levels within 2 days. CONCLUSIONS/SIGNIFICANCE: Deforesting mangroves that grow on peat soils results in CO(2 emissions that are comparable to rates estimated for peat collapse in other tropical ecosystems. Preventing deforestation presents an opportunity for countries to benefit from carbon payments for preservation of threatened carbon stocks.

  10. Shanghai Clearing House to Roll out Renminbi-denominated Copper Clearing Operations in Free Trade Zone

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    <正>Clearing House Financial Markets Co.,Ltd.(Shanghai Clearing House)General Manager Xie Zhong told the media recently at the briefing of the international symposium of"Reform Deepening and Mechanism Innovation of the Post-crisis Kerb Market",Shanghai Clearing House will explore the feasibility of carrying out bond business in

  11. Clear plastic cups: a childhood choking hazard.

    Science.gov (United States)

    Weiss, R L; Goldstein, M N; Dharia, A; Zahtz, G; Abramson, A L; Patel, M

    1996-11-01

    The disposable plastic beverage cup is not usually regarded as hazardous to young children. Certain varieties of these products however, are manufactured from a brittle, clear plastic that easily cracks and fragments. While most conscientious parents keep their children safe from peanuts, balloons, and other known choking hazards, a child can surreptitiously bite a cup edge and aspirate the fragment. We report two cases of foreign body aspiration involving clear plastic cups that went undetected one of which remained 21 months following a negative rigid bronchoscopy. Diagnostic difficulties are related to the transparency and radiolucency of these objects. When suspicious of foreign body aspiration in children, otolaryngologists should inquire about the availability of clear plastic cups in the household and be mindful of the diagnostic pitfalls. Further investigations including CT scanning and repeat bronchoscopy may be helpful in cases of suspected missed foreign bodies. An educational campaign aimed at prevention and placement of product package warning labels should be established.

  12. Clear cell carcinoma of the female genital tract (not everything is as clear as it seems).

    Science.gov (United States)

    Offman, Saul L; Longacre, Teri A

    2012-09-01

    Clear cell carcinoma has a storied history in the female genital tract. From the initial designation of ovarian clear cell adenocarcinoma as "mesonephroma" to the linkage between vaginal clear cell carcinoma and diethylstilbestrol exposure in utero, gynecologic tract clear cell tumors have puzzled investigators, posed therapeutic dilemmas for oncologists, and otherwise presented major differential diagnostic challenges for pathologists. One of the most common errors in gynecologic pathology is misdiagnosis of clear cell carcinoma, on both frozen section and permanent section. Given the poor response to platinum-based chemotherapy for advanced-stage disease and increased risk of thromboembolism, accurate diagnosis of clear cell carcinoma is important in the female genital tract. This review (1) presents the clinical and pathologic features of female genital tract clear cell carcinomas; (2) highlights recent molecular developments; (3) identifies areas of potential diagnostic confusion; and (4) presents solutions for these diagnostic problems where they exist.

  13. The management of clear cell sarcoma

    NARCIS (Netherlands)

    Kuiper, DR; Hoekstra, HJ; Veth, RPH; Wobbes, T

    2003-01-01

    Clear cell sarcoma is a rare soft tissue tumour, constituting approximately 1% of all soft tissue sarcomas. Prognosis is reported to be poor due to the great propensity to metastasise regionally and distantly. In this paper, we report the surgical experience of two university hospitals. Both disease

  14. Clearing and settlement of exchange traded derivatives

    OpenAIRE

    John McPartland

    2009-01-01

    Derivatives are a class of financial instruments that derive their value from some underlying commodity, security, index, or other asset. Futures and options are common forms of derivatives. This article explains how clearing and settlement systems for exchange traded derivatives work.

  15. 中巴资源卫星影像HR数据在煤矿矿区地面塌陷调查中的应用%Application of CBERS HR Image Data in Investigation of Surface Collapse in Coal Mine Zone

    Institute of Scientific and Technical Information of China (English)

    陈文平; 范英霞; 韩小明; 薛磊; 李少贞

    2012-01-01

    We apply, for the first time, the CBERS HR image data whose independent intellectual property rights are owned by China to investigate the surface collapse of coal mine zone through remote sensing technique. A problem which grows serious over time is coal mine zone' s surface collapse which features itself by its growing area and both its gradual and sudden change. It is difficult to deter- mine the boundary of the collapse zone and adapt to the development of the problem via conventional station observation. In this paper, we construct a remote sensing image lettering and interpreting system to interpret and delineate the boundary of collapse zones, collect relevant data and support the environmental protection of the region via human computer interaction using Liudaowan - Tieehanggou coal mine zone' s CBERS satellite HR image based on known fundamental features of the collapse zone as a case study.%首次应用具有我国自主知识产权的中巴资源卫星影像数据对煤矿矿区采煤地面塌陷进行遥感调查研究。煤矿采空区地面塌陷随着时间日趋严重,面积不断扩大,兼有渐变和突变的特点,用常规方法定点观测难以适应其发展,确定其边界分布非常困难。文章应用中巴资源卫星HR高分辨率影像数据,以六道湾一铁厂沟煤矿矿区为例,通过已知塌陷区的基本特点,建立塌陷区的遥感影像地物解译标志体系,通过人机交互遥感影像解译,圈定地面塌陷的边界并获得塌陷区的有关数据,为该地区环境地质灾害治理提供依据。

  16. Cellulose Degradation by Cellulose-Clearing and Non-Cellulose-Clearing Brown-Rot Fungi

    OpenAIRE

    Highley, Terry L.

    1980-01-01

    Cellulose degradation by four cellulose-clearing brown-rot fungi in the Coniophoraceae—Coniophora prasinoides, C. puteana, Leucogyrophana arizonica, and L. olivascens—is compared with that of a non-cellulose-clearing brown-rot fungus, Poria placenta. The cellulose- and the non-cellulose-clearing brown-rot fungi apparently employ similar mechanisms to depolymerize cellulose; most likely a nonenzymatic mechanism is involved.

  17. Multiphoton microscopy of cleared mouse organs

    Science.gov (United States)

    Parra, Sonia G.; Chia, Thomas H.; Zinter, Joseph P.; Levene, Michael J.

    2010-05-01

    Typical imaging depths with multiphoton microscopy (MPM) are limited to less than 300 μm in many tissues due to light scattering. Optical clearing significantly reduces light scattering by replacing water in the organ tissue with a fluid having a similar index of refraction to that of proteins. We demonstrate MPM of intact, fixed, cleared mouse organs with penetration depths and fields of view in excess of 2 mm. MPM enables the creation of large 3-D data sets with flexibility in pixel format and ready access to intrinsic fluorescence and second-harmonic generation. We present high-resolution images and 3-D image stacks of the brain, small intestine, large intestine, kidney, lung, and testicle with image sizes as large as 4096×4096 pixels.

  18. Roadmap-Based Level Clearing of Buildings

    KAUST Repository

    Rodriguez, Samuel

    2011-01-01

    In this paper we describe a roadmap-based approach for a multi-agent search strategy to clear a building or multi-story environment. This approach utilizes an encoding of the environment in the form of a graph (roadmap) that is used to encode feasible paths through the environment. The roadmap is partitioned into regions, e.g., one per level, and we design region-based search strategies to cover and clear the environment. We can provide certain guarantees within this roadmap-based framework on coverage and the number of agents needed. Our approach can handle complex and realistic environments where many approaches are restricted to simple 2D environments. © 2011 Springer-Verlag.

  19. Clear cell odontogenic carcinoma: A rare case

    Directory of Open Access Journals (Sweden)

    Garima Jain

    2015-01-01

    Full Text Available Clear cell odontogenic carcinoma is a rare neoplasm with very few cases reported in the literature. We report a case of a 50-year-old female patient with the malignancy at a less common location. Diagnosis was given based on the histopathologic findings. The demographic data and understanding for this tumor needs to be strengthened by reporting all new cases, which are diagnosed, in literature.

  20. Internet compromise clears way for WSIS agreement

    CERN Multimedia

    Ermert, M

    2003-01-01

    A working group under the leadership of United Nations Secretary General Kofi Annan himself will try to resolve the deep differences on the question of Internet governance, officials said here. The group, whose exact membership wasn't immediately clear, is to propose a solution to the controversial issue that has given negotiators at the World Summit of the Information Society (WSIS) a headache (1/2 page).

  1. Optical clearing of muscle with propylene glycol

    Science.gov (United States)

    Oliveira, Luís; Lage, Armindo; Clemente, Manuel Pais; Tuchin, Valery V.

    2010-02-01

    Skeletal muscle presents an internal fibrous structure. The existence of muscle fibers surrounded by interstitial fluid originates an internal step refractive index profile that causes light scattering. One way to minimize this effect inside a muscle is to perform an optical clearing treatment, using an adequate solution that presents a refractive index higher than the interstitial fluid. We have studied muscle spectral transmittance during sample immersion in propylene glycol. With the collection of transmittance spectra registered during a period of 20 minutes of immersion we could represent spectral transmittance evolution for several wavelengths and verify that the tissue samples have become more translucent. The optical clearing effect created in the tissue samples was characterized by an increase of 45% above the natural transmittance and the variations observed in tissue mass, pH and global refractive index. We also identified the initial mechanisms of agent diffusion into the tissue and consequent tissue dehydration from the spectral transmittance evolution. The histological analysis of variations caused in the internal structure of the tissues permitted to better explain the optical clearing effect created. Considering a mathematical model developed in previous studies, we could estimate the amount of agent that was inserted into the tissue samples.

  2. The Nordic power market: Are there alternatives to expensive clearing?; Alternativer til kostbar clearing?

    Energy Technology Data Exchange (ETDEWEB)

    Nerdrum, Per Kaare; Poulsson, Christian

    2003-07-01

    The Enron scandal of 2002 has set focus on counter party risk in the Nordic power market and is an important cause of increased clearing of bilateral financial power contracts. The article discusses whether expensive clearing is always the best tool for dealing with counter party risk.

  3. CHINA'S WORST OIL LEAK CLEARED EXPENSIVELY

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ Eight days and nights of clean-up efforts after the worst oil leak ever in Chinese waters, the aftermath of a collision between two foreign ships happening at 9:35 pm on December 7 about 8 nautical miles away from the mouth of the Pearl River and near the Danjiang Island, have finally paid off. So far, hundreds of tons of waste oil and polluted water have been cleared up. A large area of oil spills has been cleaned thanks to the prompt and proper operation launched just two hours after the accident.

  4. A gap clearing kicker for Main Injector

    CERN Document Server

    Kourbanis, I; Biggs, J; Brown, B; Capista, D; Jensen, C C; Krafczyk, G E; Morris, D K; Scott, D; Seiya, K; Ward, S R; Wu, G; Yang, M -J

    2012-01-01

    Fermilab Main Injector has been operating at high Beam Power levels since 2008 when multi-batch slip stacking became operational. In order to maintain and increase the beam power levels the localized beam loss due to beam left over in the injection kicker gap during slip stacking needs to be addressed. A set of gap clearing kickers that kick any beam left in the injection gap to the beam abort have been built. The kickers were installed in the summer of 2009 and became operational in November of 2010. The kicker performance and its effect on the beam losses will be described.

  5. Malignant Clear Cell Hidradenoma of the Breast

    Science.gov (United States)

    Rahal, Ahmad K.; Reddy, Pavan S; Kallail, K. James

    2017-01-01

    A 58-year-old female had a mass in the right breast palpable beneath the areola. A mammogram revealed a 1.5-centimeter soft tissue density that was confirmed with a subsequent ultrasound. The patient underwent a core needle biopsy which was initially reported as a moderately differentiated invasive ductal carcinoma. Immunohistochemical analysis revealed negative staining for estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor (HER2), mammaglobin, and gross cystic disease fluid protein 15 (GCDFP-15). A wide local excision of the mass was performed. The pathology report stated the tumor had an infiltrative growth pattern with a desmoplastic stromal response with enhanced epithelial atypia consistent with malignant transformation of a nodular clear cell hidradenoma. Clear cell hidradenoma is a very rare tumor originating from the sweat gland and has a propensity for the face and extremities. The malignant variant of this tumor is extremely rare and has been reported to originate from the breast in few cases. This case represents the difficulty in diagnosing this tumor along with the radiographic and histologic features that can distinguish this malignancy from other entities.

  6. Comparative properties of optically clear epoxy encapsulants

    Science.gov (United States)

    Edwards, Maury; Zhou, Yan

    2001-12-01

    Three epoxy systems were evaluated for physical dn optical properties. The three systems chosen for the study were selected on the basis of their optical clarity, color and chemistry. Three distinctly different chemistries were chosen, aromatic epoxy-amine cured. Aromatic epoxy- anhydride cured and cycloaliphatic epoxy-anhydride cured. All three systems remained optically clear and water-white after full cure. The three selected systems were tested for physical properties, adhesion and light transmission properties. Light transmission was measured after thermal and humidity exposure. Adhesion was measured after humidity exposure only. Both of the epoxy-anhydride systems performed well in optical properties but poorer in adhesion as compared to the epoxy-amine system. The aromatic epoxy- amine system discolored badly during thermal exposure at 100 C. Data generated from this work will be used in selecting clear encapsulating materials for photonics applications. No single system offers optimal performance in all areas. The best compromise material is the aromatic epoxy-anhydride system.

  7. An unusual case of clear cell meningioma

    Directory of Open Access Journals (Sweden)

    Deb Prabal

    2009-01-01

    Full Text Available Clear-cell meningioma (CCM is an uncommon, aggressive variant of meningioma, usually affecting younger females and having predilection for infratentorial locations. We present a rare case of recurrent supratentorial CCM in a 58-year-old male. Ten years back, he had an intra-axial tumor in the left occipital lobe, which was managed by surgical excision and radiotherapy. Currently, the patient presented with sudden severe headache along with speech and vision disturbances. Neuroimaging revealed an extra-axial parietooccipital tumor, with intratumoural bleed. Histopathology of both tumors showed features of CCM, immunopositive for epithelial membrane antigen (EMA and vimentin. This case illustrates multiple unusual features of a rare variant of meningioma in the form of affection of an adult age group, supratentorial location, recurrence, and intratumoral bleed. It also highlights the importance of incorporating immunohistochemistry in the diagnostic workup, to exclude CCM mimics, each having distinctive biological behavior, and prognostic outcome, and warranting different therapeutic protocols.

  8. MI Gap Clearing Kicker Magnet Design Review

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, Chris; /Fermilab

    2008-10-01

    The kicker system requirements were originally conceived for the NOvA project. NOvA is a neutrino experiment located in Minnesota. To achieve the desired neutrino flux several upgrades are required to the accelerator complex. The Recycler will be used as a proton pre-injector for the Main Injector (MI). As the Recycler is the same size as the MI, it is possible to do a single turn fill ({approx}11 {micro}sec), minimizing the proton injection time in the MI cycle and maximizing the protons on target. The Recycler can then be filled with beam while the MI is ramping to extract beam to the target. To do this requires two new transfer lines. The existing Recycler injection line was designed for 10{pi} pbar beams, not the 20{pi} proton beams we anticipate from the Booster. The existing Recycler extraction line allows for proton injection through the MI, while we want direct injection from the Booster. These two lines will be decommissioned. The new injection line from the MI8 line into the Recycler will start at 848 and end with injection kickers at RR104. The new extraction line in the RR30 straight section will start with a new extraction kicker at RR232 and end with new MI injection kickers at MI308. Finally, to reduce beam loss activation in the enclosure, a new gap clearing kicker will be used to extract uncaptured beam created during the slip stack injection process down the existing dump line. It was suggested that the MI could benefit from this type of system immediately. This led to the early installation of the gap clearing system in the MI, followed by moving the system to Recycler during NOvA. The specifications also changed during this process. Initially the rise and fall time requirements were 38 ns and the field stability was {+-}1%. The 38 ns is based on having a gap of 2 RF buckets between injections. (There are 84 RF buckets that can be filled from the Booster for each injection, but 82 would be filled with beam. MI and Recycler contain 588 RF buckets

  9. Clear Channel Assessment in Integrated Medical Environments

    Directory of Open Access Journals (Sweden)

    Bin Zhen

    2008-03-01

    Full Text Available Complementary WLAN and WPAN technologies as well as other wireless technologies will play a fundamental role in the medical environments to support ubiquitous healthcare delivery. This paper investigates clear channel assessment (CCA and its impact on the coexistence of WLAN (IEEE 802.11 high rate direct sequence spread spectrum (HR/DSSS PHY and WPAN (IEEE 802.15.4b in the 2.4 GHz industrial, scientific, and medical (ISM band. We derived closed-form expressions of both energy-based CCA and feature-based CCA. We qualified unequal sensing abilities between them and termed this inequality asymmetric CCA, which is different from the traditional “hidden node” or “exposed node” issues in the homogeneous network. The energy-based CCA was considered in the considered integrated medical environment because the 2.4 GHz ISM band is too crowded to apply feature-based CCA. The WPAN is oversensitive to the 802.11 HR/DSSS signals and the WLAN is insensitive to the 802.15.4b signals. Choosing an optimal CCA threshold requires some prior knowledge of the underlying signals. In the integrated medical environment we considered here, energy-based CCA can effectively avoid possible packet collisions when they are close within the “heterogeneous exclusive CCA range” (HECR. However, when they are separated beyond the HECR, WPAN can still sense the 802.11 HR/DSSS signals, but WLAN loses its sense to the 802.15.4b signals. The asymmetric CCA leads to WPAN traffic in a position secondary to WLAN traffic.

  10. Clear Channel Assessment in Integrated Medical Environments

    Directory of Open Access Journals (Sweden)

    Hara Shinsuke

    2008-01-01

    Full Text Available Abstract Complementary WLAN and WPAN technologies as well as other wireless technologies will play a fundamental role in the medical environments to support ubiquitous healthcare delivery. This paper investigates clear channel assessment (CCA and its impact on the coexistence of WLAN (IEEE 802.11 high rate direct sequence spread spectrum (HR/DSSS PHY and WPAN (IEEE 802.15.4b in the 2.4 GHz industrial, scientific, and medical (ISM band. We derived closed-form expressions of both energy-based CCA and feature-based CCA. We qualified unequal sensing abilities between them and termed this inequality asymmetric CCA, which is different from the traditional "hidden node" or "exposed node" issues in the homogeneous network. The energy-based CCA was considered in the considered integrated medical environment because the 2.4 GHz ISM band is too crowded to apply feature-based CCA. The WPAN is oversensitive to the 802.11 HR/DSSS signals and the WLAN is insensitive to the 802.15.4b signals. Choosing an optimal CCA threshold requires some prior knowledge of the underlying signals. In the integrated medical environment we considered here, energy-based CCA can effectively avoid possible packet collisions when they are close within the "heterogeneous exclusive CCA range" (HECR. However, when they are separated beyond the HECR, WPAN can still sense the 802.11 HR/DSSS signals, but WLAN loses its sense to the 802.15.4b signals. The asymmetric CCA leads to WPAN traffic in a position secondary to WLAN traffic.

  11. When a Cleared Rape Is Not Cleared: A Multilevel Study of Arrest and Exceptional Clearance.

    Science.gov (United States)

    Walfield, Scott M

    2016-05-01

    As rape remains one of the most underreported and least likely to be cleared of the violent crimes, it is of paramount importance to understand the factors associated with the likelihood of a case being cleared by law enforcement. This study uses data from the National Incident-Based Reporting System (NIBRS) and the Law Enforcement Management and Administrative Statistics (LEMAS), and a multilevel modeling approach to examine the relationship between victim, offender, incident, and police department characteristics contrasting the two types of clearance: arrest and exceptional clearance. The latter occurs due to reasons outside of law enforcement's control and despite being considered cleared, the offender is not arrested, charged, nor turned over for prosecution. Of the 16,231 cleared rapes in 238 departments, nearly half (47%) results in exceptional clearance when the victim refuses to cooperate or when prosecution is declined. Incident-level variables have a greater effect on the likelihood of exceptional clearance than victim and offender variables. The department explained a nontrivial amount of variation in the dependent variable, as 37% of the variance in type of clearance was between-department variation. Implications for future research on exceptional clearance and NIBRS are discussed.

  12. MODIS Collection 6 Clear Sky Restoral (CSR): Filtering Cloud Mast 'Not Clear' Pixels

    Science.gov (United States)

    Meyer, Kerry G.; Platnick, Steven Edward; Wind, Galina; Riedi, Jerome

    2014-01-01

    Correctly identifying cloudy pixels appropriate for the MOD06 cloud optical and microphysical property retrievals is accomplished in large part using results from the MOD35 1km cloud mask tests (note there are also two 250m subpixel cloud mask tests that can convert the 1km cloudy designations to clear sky). However, because MOD35 is by design clear sky conservative (i.e., it identifies "not clear" pixels), certain situations exist in which pixels identified by MOD35 as "cloudy" are nevertheless likely to be poor retrieval candidates. For instance, near the edge of clouds or within broken cloud fields, a given 1km MODIS field of view (FOV) may in fact only be partially cloudy. This can be problematic for the MOD06 retrievals because in these cases the assumptions of a completely overcast homogenous cloudy FOV and 1-dimensional plane-parallel radiative transfer no longer hold, and subsequent retrievals will be of low confidence. Furthermore, some pixels may be identified by MOD35 as "cloudy" for reasons other than the presence of clouds, such as scenes with thick smoke or lofted dust, and should therefore not be retrieved as clouds. With such situations in mind, a Clear Sky Restoral (CSR) algorithm was introduced in C5 that attempts to identify pixels expected to be poor retrieval candidates. Table 1 provides SDS locations for CSR and partly cloudy (PCL) pixels.

  13. Clear cell renal cell tumors: Not all that is "clear" is cancer.

    Science.gov (United States)

    Williamson, Sean R; Cheng, Liang

    2016-07-01

    Continued improvement of our understanding of the clinical, histologic, and genetic features of renal cell tumors has progressively evolved renal tumor classification, revealing an expanding array of distinct tumor types with different implications for prognosis, patient counseling, and treatment. Although clear cell renal cell carcinoma is unequivocally the most common adult renal tumor, there is growing evidence that some "clear cell" renal neoplasms, such as exemplified by multilocular cystic clear cell renal neoplasm of low malignant potential (formerly multilocular cystic renal cell carcinoma), do not have the same potential for insidious progression and metastasis, warranting reclassification as low malignant potential tumors or benign neoplasms. Still other novel tumor types such as clear cell papillary renal cell carcinoma have been more recently recognized, which similarly have shown a conspicuous absence of aggressive behavior to date, suggesting that these too may be recategorized as noncancerous or may be premalignant neoplasms. This importance for prognosis is increasingly significant in the modern era, in which renal masses are increasingly found incidentally by imaging techniques at a small tumor size, raising consideration for less aggressive management options guided by renal mass biopsy diagnosis, including imaging surveillance, tumor ablation, or partial nephrectomy.

  14. Differences in regeneration between hurricane damaged and clear-cut mangrove stands 25 years after clearing

    OpenAIRE

    Ferwerda, J.G.; Ketner, P.; McGuiness, K.A.

    2007-01-01

    The effect of human disturbance on mangrove forest may be substantially different from the effects of natural disturbances. This paper describes differences in vegetation composition and structure of five vegetation types in two mangrove areas near Darwin, Australia, 25 years after disturbance. The vegetation in clear-felled forest showed more adult Avicennia marina than in the hurricane-affected forest, and a virtual absence of A. marina juveniles and saplings. This indicates that A. marina ...

  15. CLEARS An Education and Research Tool for Computational Semantics

    CERN Document Server

    Milward, D; Maier, Hans J; Pinkal, M; Milward, David; Konrad, Karsten; Maier, Holger; Pinkal, Manfred

    1996-01-01

    The CLEARS (Computational Linguistics Education and Research for Semantics) tool provides a graphical interface allowing interactive construction of semantic representations in a variety of different formalisms, and using several construction methods. CLEARS was developed as part of the FraCaS project which was designed to encourage convergence between different semantic formalisms, such as Montague-Grammar, DRT, and Situation Semantics. The CLEARS system is freely available on the WWW from http://coli.uni-sb.de/~clears/clears.html

  16. Solubility determination from clear points upon solvent addition

    NARCIS (Netherlands)

    Reus, M.A.; Heijden, A.E.D.M. van der; Horst, J.H. ter

    2015-01-01

    A method is described for determining the solubility of multicomponent crystalline compounds from clear points upon sample dilution at a constant temperature. Clear points are established by continuously adding a solvent mixture to a suspension of known composition until a clear solution appears. Fo

  17. 78 FR 14097 - Pulse Oximeters-Premarket Notification Submissions [510(k)s]; Guidance for Industry and Food and...

    Science.gov (United States)

    2013-03-04

    ... HUMAN SERVICES Food and Drug Administration Pulse Oximeters--Premarket Notification Submissions... availability of the guidance entitled ``Pulse Oximeters--Premarket Notification Submissions .'' This guidance document pertains to non-invasive pulse oximeters intended for prescription use to measure arterial...

  18. Global ballast water management and the "same location" concept: a clear term or a clear issue?

    Science.gov (United States)

    David, Matej; Gollasch, Stephan; Pavliha, Marko

    2013-03-01

    The United Nations recognized the transfer of harmful organisms and pathogens across natural barriers as one of the four greatest pressures to the world's oceans and seas, causing global environmental changes, while also posing a threat to human health, property, and resources. Ballast water transferred by vessels was recognized as a prominent vector of such species and was regulated by the International Convention for the Control and Management of Ship's Ballast Water and Sediments (2004). Permanent exceptions from ballast water management requirements may apply when the uptake and discharge of ballast water occur at the "same location." However, the "same location" concept may be interpreted differently, e.g., a port basin, a port, an anchorage, or a larger area even with more ports inside. Considering that the Convention is nearing the beginning of enforcement, national authorities all around the world will soon be exposed to applications for exceptions. Here we consider possible effects of different interpretations of the "same location" concept. We have considered different possible extensions of the same location through environmental, shipping, and legal aspects. The extension of such areas, and the inclusion of more ports, may compromise the Convention's main purpose. We recommend that "same location" mean the smallest practicable unit, i.e., the same harbor, mooring, or anchorage. An entire smaller port, possibly also including the anchorage, could be considered as same location. For larger ports with a gradient of environmental conditions, "same location" should mean a terminal or a port basin. We further recommend that IMO consider the preparation of a guidance document to include concepts, criteria, and processes outlining how to identify "same location," which limits should be clearly identified.

  19. Optimized optical clearing method for imaging central nervous system

    Science.gov (United States)

    Yu, Tingting; Qi, Yisong; Gong, Hui; Luo, Qingming; Zhu, Dan

    2015-03-01

    The development of various optical clearing methods provides a great potential for imaging entire central nervous system by combining with multiple-labelling and microscopic imaging techniques. These methods had made certain clearing contributions with respective weaknesses, including tissue deformation, fluorescence quenching, execution complexity and antibody penetration limitation that makes immunostaining of tissue blocks difficult. The passive clarity technique (PACT) bypasses those problems and clears the samples with simple implementation, excellent transparency with fine fluorescence retention, but the passive tissue clearing method needs too long time. In this study, we not only accelerate the clearing speed of brain blocks but also preserve GFP fluorescence well by screening an optimal clearing temperature. The selection of proper temperature will make PACT more applicable, which evidently broaden the application range of this method.

  20. The Clearing : Heidegger’s Lichtung and the big scrub

    Directory of Open Access Journals (Sweden)

    Garbutt, Rob

    2010-01-01

    Full Text Available Clearings make settlement possible. Whether on a small scale using an axe and other hand implements to make way for a dwelling and a garden, or on a large scale with a chain strung between two D9 bulldozers in preparation for a major agribusiness development, the process of clearing creates spaces for installing something new. This paper uses the idea of (the clearing, as practice, process, outcome and metaphor, to examine the installation of the locals in a settler society. Using Lismore on the far-north coast of New South Wales, Australia, as a case example, the particular work of clearing that is discussed here is a practice that enables a form of colonisation and settlement that distances itself from its history of migration. This is a history of settler locals who were 'always here', and a colonial form of clearing clears the land and the mind of troubling pasts and of troubling presences. For the locals within a place, then, clearing manages and simplifies a complex set of social and material relations, histories and identities.Using Anthony Appiah's concept the 'space clearing gesture', the paper concludes with a reflection on the space in which the idea of "the clearing" and this paper appears. Do places, in this instance rural places, provide a type of clearing in which certain ideas might appear that may not appear elsewhere? If situatedness matters then the diversity of places where thinking is done is important for our ecology of thought, and in connection with this, perhaps what 'rural cultural studies' does is clear a particular type of space for thinking.

  1. The Clearing: Heidegger’s Lichtung and The Big Scrub

    Directory of Open Access Journals (Sweden)

    Rob Garbutt

    2010-02-01

    Full Text Available Clearings make settlement possible. Whether on a small scale using an axe and other hand implements to make way for a dwelling and a garden, or on a large scale with a chain strung between two D9 bulldozers in preparation for a major agribusiness development, the process of clearing creates spaces for installing something new. This paper uses the idea of (the clearing, as practice, process, outcome and metaphor, to examine the installation of the locals in a settler society. Using Lismore on the far-north coast of New South Wales, Australia, as a case example, the particular work of clearing that is discussed here is a practice that enables a form of colonisation and settlement that distances itself from its history of migration. This is a history of settler locals who were 'always here', and a colonial form of clearing clears the land and the mind of troubling pasts and of troubling presences. For the locals within a place, then, clearing manages and simplifies a complex set of social and material relations, histories and identities. Using Anthony Appiah's concept the 'space clearing gesture', the paper concludes with a reflection on the space in which the idea of "the clearing" and this paper appears. Do places, in this instance rural places, provide a type of clearing in which certain ideas might appear that may not appear elsewhere? If situatedness matters then the diversity of places where thinking is done is important for our ecology of thought, and in connection with this, perhaps what 'rural cultural studies' does is clear a particular type of space for thinking.

  2. Behind the money market: clearing and settling money market instruments

    OpenAIRE

    David L. Mengle

    1992-01-01

    When a money market instrument is traded, the clearing and settlement process establishes the change in ownership. Because the process involves both costs and risks, money market participants have developed means of making clearing and settlement more efficient and less risky.

  3. Glycogen-rich clear cell carcinoma of the breast

    DEFF Research Database (Denmark)

    Sørensen, Flemming Brandt; Paulsen, S M

    1987-01-01

    The light microscopic, immunohistochemical and ultrastructural features of a clear cell carcinoma of the breast have been studied. Both intraductal and invasive components were found. Histochemistry showed large amounts of intracytoplasmic glycogen and sparse neutral mucin in the tumour. The tumour...... was classified as a mucin-containing variant of glycogen-rich, clear cell carcinoma of the breast....

  4. 75 FR 63113 - Financial Resources Requirements for Derivatives Clearing Organizations

    Science.gov (United States)

    2010-10-14

    ... customers or themselves, and non-FCMs that clear solely on behalf of themselves. See also the definition of... member may have a specific incentive to pay an assessment depending on the size and profitability of its... purposes of this calculation, if a clearing member had pays in both its house and customer accounts,...

  5. The Effectiveness of Clear Speech as a Masker

    Science.gov (United States)

    Calandruccio, Lauren; Van Engen, Kristin; Dhar, Sumitrajit; Bradlow, Ann R.

    2010-01-01

    Purpose: It is established that speaking clearly is an effective means of enhancing intelligibility. Because any signal-processing scheme modeled after known acoustic-phonetic features of clear speech will likely affect both target and competing speech, it is important to understand how speech recognition is affected when a competing speech signal…

  6. A New Type of distributed Enamel based Clearing Electrode

    CERN Document Server

    Kroyer, T; Caspers, Friedhelm; Hellmond, P; Métral, E; Wendel, J C; Zimmermann, F

    2007-01-01

    Clearing electrodes can be used for electron cloud (EC) suppression in high intensity particle accelerators. In this paper the use of low and highly resistive layers on a dielectric substrate are examined. The beam coupling impedance of such a structure is evaluated. Furthermore the clearing efficiency as well as technological issues are discussed.

  7. 76 FR 14471 - Clearing Agency Standards for Operation and Governance

    Science.gov (United States)

    2011-03-16

    ... Operation and Governance; Proposed Rule #0;#0;Federal Register / Vol. 76, No. 51 / Wednesday, March 16, 2011... Standards for Operation and Governance AGENCY: Securities and Exchange Commission. ACTION: Proposed rule... clearing agencies and standards for the operation and governance of clearing agencies. The proposed...

  8. ClearPEM: prototype PET device dedicated to breast imaging

    CERN Multimedia

    Joao Varela

    2009-01-01

    Clinical trials have begun in Portugal on a new breast imaging system (ClearPEM) using positron emission tomography (PET). The system, developed by a Portuguese consortium in collaboration with CERN and laboratories participating in the Crystal Clear collaboration, will detect even the smallest tumours and thus help avoid unnecessary biopsies.

  9. 18 CFR 367.1840 - Account 184, Clearing accounts.

    Science.gov (United States)

    2010-04-01

    ... ACT Balance Sheet Chart of Accounts Deferred Debits § 367.1840 Account 184, Clearing accounts. This account must include undistributed balances in clearing accounts at the date of the balance sheet... accounts. 367.1840 Section 367.1840 Conservation of Power and Water Resources FEDERAL ENERGY...

  10. A simple formula for determining globally clear skies

    Energy Technology Data Exchange (ETDEWEB)

    Long, C.N.; George, A.T.; Mace, G.G. [Penn State Univ., University Park, PA (United States)] [and others

    1996-04-01

    Surface measurements to serve as {open_quotes}ground truth{close_quotes} are of primary importance in the development of retrieval algorithms using satellite measurements to predict surface irradiance. The most basic algorithms of this type deal with clear sky (i.e., cloudless) top-to-surface shortwave (SW) transfer, serving as a necessary prerequisite towards treating both clear and cloudy conditions. Recently, atmosphere SW cloud forcing to infer the possibility of excess atmospheric absorption (compared with model results) in cloudy atmospheres. The surface component of this ratio relies on inferring the expected clear sky SW irradiance to determine the effects of clouds on the SW energy budget. Solar renewable energy applications make use of clear and cloud fraction climatologies to assess solar radiation resources. All of the above depend to some extent on the identification of globally clear sky conditions and the attendant measurements of downwelling SW irradiance.

  11. Molecular basis for optical clearing of collagenous tissues

    Science.gov (United States)

    Hirshburg, Jason M.; Ravikumar, Krishnakumar M.; Hwang, Wonmuk; Yeh, Alvin T.

    2010-09-01

    Molecular interactions of optical clearing agents were investigated using a combination of molecular dynamics (MD) simulations and optical spectroscopy. For a series of sugar alcohols with low to high optical clearing potential, Raman spectroscopy and integrating sphere measurements were used to quantitatively characterize tissue water loss and reduction in light scattering following agent exposures. The rate of tissue water loss was found to correlate with agent optical clearing potential, but equivalent tissue optical clearing was measured in native and fixed tissue in vitro, given long-enough exposure times to the polyol series. MD simulations showed that the rate of tissue optical clearing correlated with the preferential formation of hydrogen bond bridges between agent and collagen. Hydrogen bond bridge formation disrupts the collagen hydration layer and facilitates replacement by a chemical agent to homogenize tissue refractive index. However, the reduction in tissue light scattering did not correlate with the agent index of refraction. Our results suggest that a necessary property of optical clearing agents is hyperosmolarity to tissue, but that the most effective agents with the highest rates of optical clearing are a subset with the highest collagen solubilities.

  12. Clear cell sarcoma: A case mimicking primary cutaneous malignant melanoma

    Directory of Open Access Journals (Sweden)

    Rodriguez-Martin M

    2009-01-01

    Full Text Available Clear cell sarcoma (CCS is a recently described variant of sarcoma characterized by prominent clear cells showing features similar to clear cell melanoma. This neoplasm was first described by Dr. Franz M. Erzinger. Primary CCS usually arises in deeper soft tissues, in association with fascia, tendons, or aponeuroses. Characteristic translocation t(12;22 (q13;q12 has been considered pathognomonic for CCS. Prognosis is related to tumor size. An early recognition and initial radical surgery is the key to a favourable outcome. We present a patient with an unusual neoplasm that resembled malignant melanoma.

  13. Clear-PEM, a dedicated PET camera for mammography

    CERN Document Server

    Lecoq, P

    2002-01-01

    Preliminary results suggest that Positron Emission Mammography (PEM) can offer a noninvasive method for the diagnosis of breast cancer. Metabolic images from PEM contain unique information not available from conventional morphologic imaging techniques and aid in expeditiously establishing the diagnosis of cancer. A dedicated machine seems to offer better perspectives in terms of position resolution and sensitivity. This paper describes the concept of Clear-PEM, the system presently developed by the Crystal Clear Collaboration at CERN for an evaluation of this approach. This device is based on new crystals introduced by the Crystal Clear as well as on modern data acquisition techniques developed for the large experiments in high energy physics experiments.

  14. Reconstruction of Clear-PEM data with STIR

    CERN Document Server

    Martins, M V; Rodrigues, P; Trindade, A; Oliveira, N; Correia, M; Cordeiro, H; Ferreira, N C; Varela, J; Almeida, P

    2006-01-01

    The Clear-PEM scanner is a device based on planar detectors that is currently under development within the Crystal Clear Collaboration, at CERN. The basis for 3D image reconstruction in Clear-PEM is the software for tomographic image reconstruction (STIR). STIR is an open source object-oriented library that efficiently deals with the 3D positron emission tomography data sets. This library was originally designed for the traditional cylindrical scanners. In order to make its use compatible with planar scanner data, new functionalities were introduced into the library's framework. In this work, Monte Carlo simulations of the Clear-PEM scanner acquisitions were used as input for image reconstruction with the 3D OSEM algorithm available in STIR. The results presented indicate that dual plate PEM data can be accurately reconstructed using the enhanced STIR framework.

  15. Molecular Air Data Clear Air Turbulence Sensor: MADCAT Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Clear air turbulence (CAT), often referred to as "air pockets," is attributed to Kelvin-Helmholtz instabilities at altitudes generally above 18,000ft, often in the...

  16. Molecular Air Data Clear Air Turbulence Sensor: MADCAT Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Clear air turbulence (CAT), often referred to as "air pockets," is attributed to Kelvin-Helmholtz instabilities at altitudes usually above 18,000ft, often without...

  17. Global horizontal irradiance clear sky models : implementation and analysis.

    Energy Technology Data Exchange (ETDEWEB)

    Stein, Joshua S.; Hansen, Clifford W.; Reno, Matthew J.

    2012-03-01

    Clear sky models estimate the terrestrial solar radiation under a cloudless sky as a function of the solar elevation angle, site altitude, aerosol concentration, water vapor, and various atmospheric conditions. This report provides an overview of a number of global horizontal irradiance (GHI) clear sky models from very simple to complex. Validation of clear-sky models requires comparison of model results to measured irradiance during clear-sky periods. To facilitate validation, we present a new algorithm for automatically identifying clear-sky periods in a time series of GHI measurements. We evaluate the performance of selected clear-sky models using measured data from 30 different sites, totaling about 300 site-years of data. We analyze the variation of these errors across time and location. In terms of error averaged over all locations and times, we found that complex models that correctly account for all the atmospheric parameters are slightly more accurate than other models, but, primarily at low elevations, comparable accuracy can be obtained from some simpler models. However, simpler models often exhibit errors that vary with time of day and season, whereas the errors for complex models vary less over time.

  18. Coastal sediment elevation change following anthropogenic mangrove clearing

    Science.gov (United States)

    Hayden, Heather L.; Granek, Elise F.

    2015-11-01

    Coastal mangrove forests along tropical shorelines serve as an important interface between land and sea. They provide a physical buffer protecting the coastline from erosion and act as sediment "traps" catching terrestrial sediment, thus preventing smothering of subtidal coral reefs. Coastal development that removes mangrove habitat may impact adjacent nearshore coral reefs through sedimentation and nutrient loading. We examined differences in sediment elevation change between patches of open-coast intact and anthropogenically cleared red mangroves (Rhizophora mangle) on the east side of Turneffe Atoll, Belize, to quantify changes following mangrove clearing. Samples were collected over a 24 month period at five study sites, each containing paired intact (+mangrove) and cleared (-mangrove) plots. Five sediment elevation pins were deployed in each plot: behind areas cleared of mangroves (-mangrove) and behind adjacent intact mangroves (+mangrove). Sediment elevation increased at intact mangrove sites (M = +3.83 mm, SE = 0.95) whereas cleared mangrove areas suffered elevation loss (M = -7.30 mm, SE = 3.38). Mangroves inshore of partial or continuous gaps in the adjacent fringing reefs had higher rates of elevation loss (M = -15.05 mm) than mangroves inshore of continuous fringing reefs (M = -1.90 mm). Our findings provide information on potential effects of mangrove clearing and the role of offshore habitat characteristics on coastal sediment trapping and maintenance of sediment elevation by mangroves. With implications for coastline capacity to adjust to sea level rise, these findings are relevant to management of coastal fringing mangrove forests across the Caribbean.

  19. Anterior Crossbite and Crowding Correction with a Series of Clear Aligners Involving Lower Incisor Extraction: "The Clear Way" Case Report.

    Science.gov (United States)

    Bawaskar, Naval Suresh

    2015-01-01

    The Clear Aligner can be used to correct tooth movement without involving extraction, surgery, and other adjunct orthopaedic appliances. Some forms ofattachments are required with clear aligners to achieve all major types of orthodontic tooth movements. The Clear Aligner is a procedure that can be performed by a clinician with computer simulation/calculation. Since the Clear Aligner can be fabricated in steps, it is readily available to change the treatment sequence throughout the course of the treatment in cases of complex malocclusions. The patient can receive any necessary dental procedures with ease during the course of the treatment. The treatment can also be easily resumed even if the patient has not worn the aligners for a period of time. The purpose of this article is to report dental anterior crossbite correction with a series of Clear Aligners without the use of any forms of attachments. The Clear Aligner could be used as an alternative in appropriate cases for those who are reluctant with conventional appliances.

  20. Mines and human casualties: a robotics approach toward mine clearing

    Science.gov (United States)

    Ghaffari, Masoud; Manthena, Dinesh; Ghaffari, Alireza; Hall, Ernest L.

    2004-10-01

    An estimated 100 million landmines which have been planted in more than 60 countries kill or maim thousands of civilians every year. Millions of people live in the vast dangerous areas and are not able to access to basic human services because of landmines" threats. This problem has affected many third world countries and poor nations which are not able to afford high cost solutions. This paper tries to present some experiences with the land mine victims and solutions for the mine clearing. It studies current situation of this crisis as well as state of the art robotics technology for the mine clearing. It also introduces a survey robot which is suitable for the mine clearing applications. The results show that in addition to technical aspects, this problem has many socio-economic issues. The significance of this study is to persuade robotics researchers toward this topic and to peruse the technical and humanitarian facets of this issue.

  1. Advanced ThioClear process testing. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Lani, B.

    1998-03-01

    Wet scrubbing is the leading proven commercial post-combustion FGD technology available to meet the sulfur dioxide reductions required by the Clean Air Act Amendments. To reduce costs associated with wet FGD, Dravo Lime Company has developed the ThioClear process. ThioClear is an ex-situ forced oxidation magnesium-enhanced lime FGD process. ThioClear process differs from the conventional magnesium-enhanced lime process in that the recycle liquor has minimal suspended solids and the by-products are wallboard quality gypsum and magnesium hydroxide, an excellent reagent for water treatment. The process has demonstrated sulfur dioxide removal efficiencies of +95% in both a vertical spray scrubber tower and a horizontal absorber operating at gas velocities of 16 fps, respectively. This report details the optimization studies and associated economics from testing conducted at Dravo Lime Company`s pilot plant located at the Miami Fort Station of the Cincinnati Gas and Electric Company.

  2. Study on application of optical clearing technique in skin diseases

    Science.gov (United States)

    Shan, Hao; Liang, Yanmei; Wang, Jingyi; Li, Yan

    2012-11-01

    So far, the study of the optical clearing is almost always about healthy tissue. However, the ultimate goal is to detect diseases for clinical application. Optical clearing on diseased skins is explored. The effect is evaluated by applying a combined liquid paraffin and glycerol mixed solution on several kinds of diseased skins in vitro. Scanning experiments from optical coherence tomography show that it has different effects among fibroma, pigmented nevus, and seborrheic keratosis. Based on the results, we conclude that different skin diseases have different compositions and structures, and their optical parameters and biological characteristics should be different, which implies that the optical clearing technique may have selectivity and may not be suitable for all kinds of skin diseases.

  3. Diagnosis of clear sky ultraviolet radiation for Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Lemus Deschamps, L. [Bureau of Meteorology Research Centre (Australia); Galindo, I.; Solano, R.; Elizalde, A.T.; Fonseca, J. [Centro Universitario de Investigaciones en Ciencias del Ambiente, University of Colima (Mexico)

    2002-07-01

    A discrete-ordinate radiative transfer model is employed to develop a regional clear sky ultraviolet (UV) diagnosis system. The clear sky UV radiation, weighted by the spectral sensitivity of human skin is calculated using the Total Ozone Mapping Spectrometer (TOMS) data sets. Examples of the geographical clear sky UV Index distributions are presented and the model results are compared with surface UV measurements from University of Colima for 1999. [Spanish] Utilizando un modelo de transferencia de radiacion de ordenadas discretas se desarrolla un sistema para el diagnostico de la distribucion de radiacion ultravioleta para cielo despejado en la Republica Mexicana. La radiacion para cielo despejado se obtiene utilizando la respuesta espectral de la piel humana y los datos de satelite de ozono total registrados por el espectrometro TOMS. Se presentan ejemplos del Indice de radiacion ultravioleta (UV Index) calculados con el modelo y se comparan con las mediciones en superficie obtenidas en la Universidad de Colima durante 1999.

  4. Clear cell colitis: A form of microscopic colitis in children

    Institute of Scientific and Technical Information of China (English)

    Jan J(o)zefczuk; Bogdan Marian Wozniewicz

    2008-01-01

    AIM: To describe a new clinical and pathological subtype of microscopic colitis in children.METHODS: A selected group of children with abdominal pain, constipation and/or diarrhoea showing discrete or no macroscopic abnormalities on endoscopy was described.RESULTS: Multiple biopsies of colon showed large mononuclear clear cells in lamina propria of mucous membrane provided that good quality histological sections were performed and observed under a higher magnification. Otherwise, they could be misinterpreted as artefacts. Their presence in routine histology might suggest a systemic storage disease (Whipple's disease), and neuronal intestine dysplasia.Using immunohistochemical staining and electron microscopy we confirmed their origin from CD68 positive mononuclear macrophages.CONCLUSION: The presence of large clear cells is a constant microscopic feature. Failure of transient large bowel stationary macrophages plays a role in the pathogenesis of this benign microscopic clear cell colitis,sometimes coexisting with allergy.

  5. Tropospheric haze and colors of the clear daytime sky.

    Science.gov (United States)

    Lee, Raymond L

    2015-02-01

    To casual observers, haze's visible effects on clear daytime skies may seem mundane: significant scattering by tropospheric aerosols visibly (1) reduces the luminance contrast of distant objects and (2) desaturates sky blueness. However, few published measurements of hazy-sky spectra and chromaticities exist to compare with these naked-eye observations. Hyperspectral imaging along sky meridians of clear and hazy skies at one inland and two coastal sites shows that they have characteristic colorimetric signatures of scattering and absorption by haze aerosols. In addition, a simple spectral transfer function and a second-order scattering model of skylight reveal the net spectral and colorimetric effects of haze.

  6. Clear cell odontogenic carcinoma of maxilla: A diagnostic challenge

    Directory of Open Access Journals (Sweden)

    Fouzia Siraj

    2016-01-01

    Full Text Available Clear cell odontogenic carcinoma (CCOC is a rare odontogenic tumor which occurs mostly in the mandible. It is primarily seen in fifth to seventh decades with a female predilection. We report a case of CCOC in the maxillary arch of a 66-year-old woman. Morphologic examination along with histochemical and immunohistochemical markers led to the establishment of the diagnosis. It is important to diagnose this entity and differentiate it from other clear cell tumors in the head and neck region as it is a locally aggressive tumor with a propensity for regional, nodal, and distant metastasis.

  7. Skin optical clearing for improvement of laser tattoo removal

    Science.gov (United States)

    Genina, Elina A.; Bashkatov, Alexey N.; Gavrilova, Anna A.; Pravdin, Alexander B.; Tuchin, Valery V.; Yaroslavsky, Ilya V.; Altshuler, Gregory B.

    2007-06-01

    The removal of tattoo pigments by laser energy is effected through a process of selective photothermolysis. Dehydration and optical immersion based on refractive index matching of scattering centers with that of surrounding matter through introduction of an exogenous index-matching agent can improve laser tattoo removal by providing increased efficiency of laser delivery to embedded ink particles and enabling the use of shorter wavelength visible lasers more effective on certain inks. Effectiveness of a method of accelerating penetration of the index-matching compounds by enhancing skin permeability through creating a lattice of micro-zones of limited thermal damage in the stratum corneum was studied. As optical clearing agents 100% and 88%-aqueous glycerol solutions were used. The effect of stratum corneum perforation on the rate of the immersion clearing of skin was studied. Dynamics of refractive index alteration of glycerol solution during its interaction with skin samples was monitored. Improvement of tattoo visualization was observed. The results of the experiments have shown that the lattice of island damage method the is effective for transepidermal delivery of optical clearing agents and could be used successfully in in vivo conditions for the enhancement of optical clearing of treated skin area and as enabling improvement of laser tattoo removal.

  8. The Search for Durable Exterior Clear Coatings for Wood

    Directory of Open Access Journals (Sweden)

    Philip D. Evans

    2015-11-01

    Full Text Available The goal of a durable exterior clear coating has eluded generations of coatings technologists, despite long-standing desire amongst the public for such a coating. The journey towards this goal initially focused on modifications to coating formulation, but took a completely different direction when it was found that a UV-transparent silicone clear coating on wood modified with chromic acid met consumer expectations of coating durability. This finding sparked world-wide interest in wood pre-treatments as a way of enhancing the durability of clear coatings. This interest initially focused on transition metal compounds, but has now shifted in the direction of organic and inorganic photostabilizers or even more drastic pre-treatments. Pre-treatments that dimensionally stabilize wood, protect it from microbial degradation and photostabilize lignin, when combined with flexible, photostable, coatings provide the next way-stop on the journey towards achieving the goal of durable exterior clear coatings for wood. This paper reviews this journey, drawing upon our research and that of other groups who have focused on this elusive goal.

  9. 76 FR 16587 - Risk Management Requirements for Derivatives Clearing Organizations

    Science.gov (United States)

    2011-03-24

    ... COMMISSION 17 CFR Part 39 RIN 3038-AC98 Risk Management Requirements for Derivatives Clearing Organizations... Principle D (Risk Management) and would establish a related reporting requirement under Core Principle J... Exchange Act (CEA) \\4\\ to establish a comprehensive regulatory framework to reduce risk,...

  10. Clearing the Fog from the Undergraduate Course in Linear Algebra

    Science.gov (United States)

    Scott, Damon

    2007-01-01

    For over a decade it has been a common observation that a "fog" passes over the course in linear algebra once abstract vector spaces are presented. See [2, 3]. We show how this fog may be cleared by having the students translate "abstract" vector-space problems to isomorphic "concrete" settings, solve the "concrete" problem either by hand or with…

  11. 31 CFR 50.12 - Clear and conspicuous disclosure.

    Science.gov (United States)

    2010-07-01

    ... INSURANCE PROGRAM Disclosures as Conditions for Federal Payment § 50.12 Clear and conspicuous disclosure. (a... circumstances of the disclosure. See § 50.17 for model forms. (b)(1) Description of premium. An insurer may..., consistent with the definition of an act of terrorism as amended by the Terrorism Risk Insurance...

  12. Marketing Strategies of United Kingdom Universities during Clearing and Adjustment

    Science.gov (United States)

    Mogaji, Emmanuel

    2016-01-01

    Purpose: The clearing system in the UK enables students without a university place after exam results have been announced to find suitable vacancies, as it is important for universities to fill their vacancies as any shortfall loses them a lot of money. The purpose of this paper is to examine marketing strategies adopted by UK universities on…

  13. Clear Speech Variants: An Acoustic Study in Parkinson's Disease

    Science.gov (United States)

    Lam, Jennifer; Tjaden, Kris

    2016-01-01

    Purpose: The authors investigated how different variants of clear speech affect segmental and suprasegmental acoustic measures of speech in speakers with Parkinson's disease and a healthy control group. Method: A total of 14 participants with Parkinson's disease and 14 control participants served as speakers. Each speaker produced 18 different…

  14. Multifocal Rhizopus microsporus lung infection following brush clearing

    Directory of Open Access Journals (Sweden)

    Artsiom V. Tsyrkunou

    2014-10-01

    Full Text Available We report a case of pulmonary Rhizopus microsporus infection in a patient with untreated diabetes following brush clearing. The patient was successfully treated with a combined medical and surgical approach with complete resolution of the lung lesions and remains asymptomatic at 11-month follow-up.

  15. Does gently clearing the nasal passage affect odor identification?

    Directory of Open Access Journals (Sweden)

    Mitchell G. Spring

    2014-12-01

    Full Text Available Identifying scents in a wine’s bouquet is considered one of the most important steps in the process of wine tasting. An individual’s ability to successfully do this is dependent on the sense of smell; thus, altering the nasal microenvironment could have a powerful effect on the wine tasting experience. In the present study, we examined olfactory performance in healthy participants who cleared their nasal cavity before odorant presentations. Fifty undergraduate participants were assessed with a standardized test of olfaction requiring the recognition of a battery of odors. Half of these participants cleared mucus from their nasal cavities (by gently blowing their noses prior to the assessment. No difference was found in performance between those who cleared their nasal passages and those who did not. Further, data were not different than known population data from the test. These data suggest that gently clearing the nasal cavity before presentation of odorants bears no effect on the ability to perceive those odor qualities.

  16. Seeing Clearly (A Cup of Health with CDC)

    Centers for Disease Control (CDC) Podcasts

    2014-05-08

    If you’re not seeing the world as clearly as you used to, you might be among the millions of people suffering from vision impairment. In this podcast, Dr. John Crews discusses ways to take care of your eyes.  Created: 5/8/2014 by MMWR.   Date Released: 5/8/2014.

  17. 19 CFR 4.60 - Vessels required to clear.

    Science.gov (United States)

    2010-04-01

    ... contiguous country otherwise than by sea. (c) Vessels which will merely transit the Panama Canal without transacting any business there shall not be required to be cleared because of such transit. (d) In the event... hours after clearance to the port director who shall note the fact of detention on the certificate...

  18. Treatment results and prognostic factors of clear cell ovarian carcinomas and ovarian carcinomas with clear cell component

    Directory of Open Access Journals (Sweden)

    M. D. Ahmedova

    2012-01-01

    Full Text Available The most important prognostic factors for clear cell carcinoma (CCC are clinical and morphological signs and clinical stage of the disease. Analyses of 5-year survival in patients with I stage of CCC is 69 %, in II stage – 55 %, in III stage – 14 % and in IV stage – 4 % patients. We analyzed distant results of treatment of 71 patients with CCC and of 25 patients with mixed malignant ovaries neoplasm with obligatory clear cell component taking into consideration main clinical and morphological sings of disease. On the base of performed reseal we revealed that morphological structure of the tumors and stage of the disease exerted heist influence on the exponent of survival of the patients with clear CCC ovaries neoplasm. Besides, there is a correlation between exponent of patients’ survival and radicalized of surgery, character of tumor growth, differentiation degree, cell anaplasia and mitotic activity of tumor cells.

  19. The potential of clear-sky carbon dioxide satellite retrievals

    Directory of Open Access Journals (Sweden)

    R. R. Nelson

    2015-12-01

    Full Text Available Since the launch of the Greenhouse Gases Observing Satellite (GOSAT in 2009, retrieval algorithms designed to infer the column-averaged dry-air mole fraction of carbon dioxide (XCO2 from hyperspectral near-infrared observations of reflected sunlight have been greatly improved. They now generally include the scattering effects of clouds and aerosols, as early work found that absorption-only retrievals, which neglected these effects, often incurred unacceptably large errors, even for scenes with optically thin cloud or aerosol layers. However, these "full-physics" retrievals tend to be computationally expensive and may incur biases from trying to deduce the properties of clouds and aerosols when there are none present. Additionally, algorithms are now available that can quickly and effectively identify and remove most scenes in which cloud or aerosol scattering plays a significant role. In this work, we test the hypothesis that non-scattering, or "clear-sky", retrievals may perform as well as full-physics retrievals for sufficiently clear scenes. Clear-sky retrievals could potentially avoid errors and biases brought about by trying to infer properties of clouds and aerosols when none are present. Clear-sky retrievals are also desirable because they are orders of magnitude faster than full-physics retrievals. Here we use a simplified version of the Atmospheric Carbon Observations from Space (ACOS XCO2 retrieval algorithm that does not include the scattering and absorption effects of clouds or aerosols. It was found that for simulated Orbiting Carbon Observatory-2 (OCO-2 measurements, the clear-sky retrieval had errors comparable to those of the full-physics retrieval. For real GOSAT data, the clear-sky retrieval had nearly indistinguishable error characteristics over land, but roughly 30–60 % larger errors over ocean, depending on filtration level, compared to the full-physics retrieval. In general, the clear-sky retrieval had XCO2 root

  20. Clear-air radar observations of the atmospheric boundary layer

    Science.gov (United States)

    Ince, Turker

    2001-10-01

    This dissertation presents the design and operation of a high-resolution frequency-modulated continuous-wave (FM- CW) radar system to study the structure and dynamics of clear-air turbulence in the atmospheric boundary layer (ABL). This sensitive radar can image the vertical structure of the ABL with both high spatial and temporal resolutions, and provide both qualitative information about the morphology of clear-air structures and quantitative information on the intensity of fluctuations in refractive-index of air. The principles of operation and the hardware and data acquisition characteristics of the radar are described in the dissertation. In October 1999, the radar participated in the Cooperative Atmosphere-Surface Exchange Study (CASES'99) Experiment to characterize the temporal structure and evolution of the boundary-layer features in both convective and stable conditions. The observed structures include clear-air convection, boundary layer evolution, gravity waves, Kelvin-Helmholtz instabilities, stably stratified layers, and clear-air turbulence. Many of the S-band radar images also show high- reflectivity returns from Rayleigh scatterers such as insects. An adaptive median filtering technique based on local statistics has, therefore, been developed to discriminate between Bragg and Rayleigh scattering in clear-air radar observations. The filter is tested on radar observations of clear air convection with comparison to two commonly used image processing techniques. The dissertation also examines the statistical mean of the radar-measured C2n for clear-air convection, and compares it with the theoretical predictions. The study also shows that the inversion height, local thickness of the inversion layer, and the height of the elevated atmospheric layers can be estimated from the radar reflectivity measurements. In addition, comparisons to the radiosonde-based height estimates are made. To examine the temporal and spatial structure of C2n , the dissertation

  1. Clear cell ovarian cancer and endometriosis: is there a relationship?

    Directory of Open Access Journals (Sweden)

    Maria Szubert

    2016-07-01

    Full Text Available Introduction: Ovarian clear cell carcinoma is a rare type of ovarian cancer. In recent years, issues of the common genetic origin of endometriosis and ovarian clear cell carcinoma have been raised. Aim of this study was to evaluate the prevalence of this type of cancer, risk factors, prognosis and its potential aetiological association with endometriosis. Material and methods: In a retrospective study, we analysed histopathological data of patients operated in the First Department of Gynaecology and Obstetrics (MU, Lodz due to ovarian cancer in 2004-2014. Among the 394 patients operated on for ovarian cancer, clear cell carcinoma was found in 0.02% (9/394. Menstrual history, parity, comorbidities, data from physical examination, operational protocols and histopathological diagnoses were analysed. Follow-up was obtained from 77.8% of patients. Statistical analysis was performed using Microsoft Excel 2013. Results: The mean age of patients at diagnosis was 57.6 years; the BMI in the study group was 27.2; the majority of patients were multiparous (77.8%. Clear cell carcinoma was detected mostly at stage Ia (n = 4. The concentration of Ca125 in the study group had an average of 142.75 U/ml and a median of 69.3 U/ml. The coexistence of endometriosis could not be clinically or histologically confirmed amongst our patients. The most common comorbidity in the study group was hypertension. Conclusions : In our clinical material, ovarian clear cell carcinoma is a rare histopathological specimen with a prognostic value comparable to that of serous ovarian cancer. Due to the rarity of this histopathological subtype, proving a cause-and-effect relationship between it and endometriosis can only be elucidated through statistical studies of the entire population.

  2. Bathymetry of Clear Creek Reservoir, Chaffee County, Colorado, 2016

    Science.gov (United States)

    Kohn, Michael S.; Kinzel, Paul J.; Mohrmann, Jacob S.

    2017-03-06

    To better characterize the water supply capacity of Clear Creek Reservoir, Chaffee County, Colorado, the U.S. Geological Survey, in cooperation with the Pueblo Board of Water Works and Colorado Mountain College, carried out a bathymetry survey of Clear Creek Reservoir. A bathymetry map of the reservoir is presented here with the elevation-surface area and the elevation-volume relations. The bathymetry survey was carried out June 6–9, 2016, using a man-operated boat-mounted, multibeam echo sounder integrated with a Global Positioning System and a terrestrial survey using real-time kinematic Global Navigation Satellite Systems. The two collected datasets were merged and imported into geographic information system software. The equipment and methods used in this study allowed water-resource managers to maintain typical reservoir operations, eliminating the need to empty the reservoir to carry out the survey.

  3. Clear sky atmosphere at cm-wavelengths from climatology data

    CERN Document Server

    Lew, Bartosz

    2015-01-01

    We utilise ground-based, balloon-born and satellite climatology data to reconstruct site and season-dependent vertical profiles of precipitable water vapour (PWV). We use these profiles to numerically solve radiative transfer through the atmosphere, and derive atmospheric brightness temperature ($T_{\\rm atm}$) and optical depth ($\\tau$) at the centimetre wavelengths. We validate the reconstruction by comparing the model column PWV, with photometric measurements of PWV, performed in the clear sky conditions towards the Sun. Based on the measurements, we devise a selection criteria to filter the climatology data to match the PWV levels to the expectations of the clear sky conditions. We apply the reconstruction to the location of the Polish 32-metre radio telescope, and characterise $T_{\\rm atm}$ and $\\tau$ year-round, at selected frequencies. We also derive the zenith distance dependence for these parameters, and discuss shortcomings of using planar, single-layer, and optically thin atmospheric model approxima...

  4. Clear cell sarcoma of the kidney: A case report

    Directory of Open Access Journals (Sweden)

    Dipanwita Nag

    2014-01-01

    Full Text Available Clear cell sarcoma of the kidney is a rare malignant neoplasm of childhood, known for its aggressiveness, its tendency for recurrence, and to metastasize to bone. We report the observation of 8-month-old child presenting with a large abdominal mass. Clinically, it was diagnosed as Wilm′s tumor, and left nephrectomy was done. Grossly, 10 cm × 8 cm × 3.5 cm globular, white, encapsulated, smooth mass uniformly involving the whole kidney was noted. Histologically, the tumor was diagnosed as clear cell sarcoma with renal vein showing presence of tumor embolus in lumen. The tumor was given stage-II (NWTS-5 protocol. Immunohistochemistry showed vimentin positive and cytokeratin negative tumor cells. The child is currently undergoing chemotherapy and has not yet shown any sign of bony metastasis.

  5. Effects of Mixing on Hopper Sedimentation in Clearing Mixtures

    DEFF Research Database (Denmark)

    Hjelmager Jensen, Jacob; Saremi, Sina

    2015-01-01

    and settling in high-concentration mixtures were examined theoretically. Analytical solutions for clearance of excess concentrations were derived for the limiting cases of (1) still-water clearance and (2) clearance when the amount of turbulence is abundant. When examining these analytical solutions......Hopper sedimentation is the result of precipitation of typically fine sediment from a homogenous, high-concentration mixture, which is not completely deficient of turbulence. If hopper sedimentation or loading is accomplished through a single-inflow system, or if the irregularity of the inflow...... concentrations is pronounced or simply terminated, then the hopper mixture will clear. Whereas turbulent mixing is redundant, when the mixture is homogeneous, it may take an active role when the mixture is clearing. The role of turbulence on hopper sedimentation has been the focus of several studies...

  6. Experimental characterization of the Clear-PEM scanner spectrometric performance

    Science.gov (United States)

    Bugalho, R.; Carriço, B.; Ferreira, C. S.; Frade, M.; Ferreira, M.; Moura, R.; Ortigão, C.; Pinheiro, J. F.; Rodrigues, P.; Rolo, I.; Silva, J. C.; Trindade, A.; Varela, J.

    2009-10-01

    In the framework of the Clear-PEM project for the construction of a high-resolution and high-specificity scanner for breast cancer imaging, a Positron Emission Mammography tomograph has been developed and installed at the Instituto Português de Oncologia do Porto hospital. The Clear-PEM scanner is mainly composed by two planar detector heads attached to a robotic arm, trigger/data acquisition electronics system and computing servers. The detector heads hold crystal matrices built from 2 × 2 × 20 mm3 LYSO:Ce crystals readout by Hamamatsu S8550 APD arrays. The APDs are optically coupled to both ends of the 6144 crystals in order to extract the DOI information for each detected event. Each one of 12288 APD's pixels is read and controlled by Application Specific Integrated Circuits water-cooled by an external cooling unit. The Clear-PEM frontend boards innovative design results in a unprecedented integration of the crystal matrices, APDs and ASICs, making Clear-PEM the PET scanner with the highest number of APD pixels ever integrated so far. In this paper, the scanner's main technical characteristics, calibration strategies and the first spectrometric performance evaluation in a clinical environment are presented. The first commissioning results show 99.7% active channels, which, after calibration, have inter-pixel and absolute gain distributions with dispersions of, respectively, 12.2% and 15.3%, demonstrating that despite the large number of channels, the system is uniform. The mean energy resolution at 511 keV is of 15.9%, with a 8.8% dispersion, and the mean CDOI-1 is 5.9%/mm, with a 7.8% dispersion. The coincidence time resolution, at 511 keV, for a energy window between 400 and 600 keV, is 5.2 ns FWHM.

  7. ClearFuels-Rentech Integrated Biorefinery Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Pearson, Joshua [Project Director

    2014-02-26

    The project Final Report describes the validation of the performance of the integration of two technologies that were proven individually on a pilot scale and were demonstrated as a pilot scale integrated biorefinery. The integrated technologies were a larger scale ClearFuels’ (CF) advanced flexible biomass to syngas thermochemical high efficiency hydrothermal reformer (HEHTR) technology with Rentech’s (RTK) existing synthetic gas to liquids (GTL) technology.

  8. Experimental characterization of the Clear-PEM scanner spectrometric performance

    Energy Technology Data Exchange (ETDEWEB)

    Bugalho, R; Carrico, B; Ferreira, C S; Frade, M; Ferreira, M; Moura, R; Ortigao, C; Pinheiro, J F; Rodrigues, P; Rolo, I; Silva, J C; Trindade, A; Varela, J [Laboratorio de Instrumentacao e Fisica Experimental de Particulas (LIP), Av. Elias Garcia 14-1, 1000-149 Lisboa (Portugal)], E-mail: frade@lip.pt

    2009-10-15

    In the framework of the Clear-PEM project for the construction of a high-resolution and high-specificity scanner for breast cancer imaging, a Positron Emission Mammography tomograph has been developed and installed at the Instituto Portugues de Oncologia do Porto hospital. The Clear-PEM scanner is mainly composed by two planar detector heads attached to a robotic arm, trigger/data acquisition electronics system and computing servers. The detector heads hold crystal matrices built from 2 x 2 x 20 mm{sup 3} LYSO:Ce crystals readout by Hamamatsu S8550 APD arrays. The APDs are optically coupled to both ends of the 6144 crystals in order to extract the DOI information for each detected event. Each one of 12288 APD's pixels is read and controlled by Application Specific Integrated Circuits water-cooled by an external cooling unit. The Clear-PEM frontend boards innovative design results in a unprecedented integration of the crystal matrices, APDs and ASICs, making Clear-PEM the PET scanner with the highest number of APD pixels ever integrated so far. In this paper, the scanner's main technical characteristics, calibration strategies and the first spectrometric performance evaluation in a clinical environment are presented. The first commissioning results show 99.7% active channels, which, after calibration, have inter-pixel and absolute gain distributions with dispersions of, respectively, 12.2% and 15.3%, demonstrating that despite the large number of channels, the system is uniform. The mean energy resolution at 511 keV is of 15.9%, with a 8.8% dispersion, and the mean C{sub DOI}{sup -1} is 5.9%/mm, with a 7.8% dispersion. The coincidence time resolution, at 511 keV, for a energy window between 400 and 600 keV, is 5.2 ns FWHM.

  9. Accuracy of the ABC/2 score for intracerebral hemorrhage: Systematic review and analysis of MISTIE, CLEAR-IVH, CLEAR III

    Science.gov (United States)

    Webb, Alastair JS; Ullman, Natalie L; Morgan, Tim C; Muschelli, John; Kornbluth, Joshua; Awad, Issam A; Mayo, Stephen; Rosenblum, Michael; Ziai, Wendy; Zuccarrello, Mario; Aldrich, Francois; John, Sayona; Harnof, Sagi; Lopez, George; Broaddus, William C; Wijman, Christine; Vespa, Paul; Bullock, Ross; Haines, Stephen J; Cruz-Flores, Salvador; Tuhrim, Stan; Hill, Michael D; Narayan, Raj; Hanley, Daniel F

    2015-01-01

    Background and Purpose The ABC/2 score estimates intracerebral hemorrhage (ICH) volume, yet validations have been limited by small samples and inappropriate outcome measures. We determined accuracy of the ABC/2 score calculated at a specialized Reading Center (RC-ABC) or local site (site-ABC) versus the reference-standard CT-based planimetry (CTP). Methods In MISTIE-II, CLEAR-IVH and CLEAR-III trials, ICH volume was prospectively calculated by CTP, RC-ABC and site-ABC. Agreement between CTP and ABC/2 was defined as an absolute difference up to 5ml and relative difference within 20%. Determinants of ABC/2 accuracy were assessed by logistic regression. Results In 4369 scans from 507 patients, CTP was more strongly correlated with RC-ABC (r2=0.93) than site-ABC (r2=0.87). Although RC-ABC overestimated CTP-based volume on average (RC-ABC=15.2cm3, CTP=12.7cm3), agreement was reasonable when categorised into mild, moderate and severe ICH (kappa 0.75, p<0.001). This was consistent with overestimation of ICH volume in 6/8 previous studies. Agreement with CTP was greater for RC-ABC (84% within 5ml; 48% of scans within 20%) than for site-ABC (81% within 5ml; 41% within 20%). RC-ABC had moderate accuracy for detecting ≥ 5ml change in CTP volume between consecutive scans (sensitivity 0.76, specificity 0.86) and was more accurate with smaller ICH, thalamic haemorrhage and homogeneous clots. Conclusions ABC/2 scores at local or central sites are sufficiently accurate to categorise ICH volume and assess eligibility for the CLEAR III and MISTIE III studies, and moderately accurate for change in ICH volume. However, accuracy decreases with large, irregular or lobar clots. Clinical Trial Registration MISTIE-II NCT00224770; CLEAR-III NCT00784134; www.clinicaltrials.gov PMID:26243227

  10. Identifying fly puparia by clearing technique: application to forensic entomology.

    Science.gov (United States)

    Sukontason, Kabkaew L; Ngern-Klun, Radchadawan; Sripakdee, Duanghatai; Sukontason, Kom

    2007-10-01

    In forensic investigations, immature stages of the fly (egg, larva, or puparia) can be used as entomological evidence at death scenes, not only to estimate the postmortem interval (PMI), analyze toxic substances, and to determine the manner of death but also to indicate the movement of a corpse in homicide cases. Of these immature stages, puparia represent the longest developmental time, which makes them of useful. However, in order for forensic entomologists to use puparia effectively, it is crucial that they are able to accurately identify the species of fly found in a corpse. Typically, these puparia are similar in general appearance, being coarctate and light brown to dark brown in color, which makes identification difficult. In this study, we report on the clearing technique used to pale the integument of fly puparia, thereby allowing observation of the anterior end (second to fourth segments) and the profile of the posterior spiracle, which are important clues for identification. We used puparia of the blowfly, Chrysomya megacephala (F.), as the model species in this experiment. With placement in a 20% potassium hydroxide solution daily and mounting on a clearing medium (Permount(R), New Jersey), the profile of the posterior spiracle could be clearly examined under a light microscope beginning on the fifth day after pupation, and the number of papillae in the anterior spiracle could be counted easily starting from the ninth day. Comparison of morphological features of C. megacephala puparia with those of other blowflies (Chrysomya nigripes [Aubertin], Chrysomya rufifacies [Macquart], Chrysomya villeneuvi [Patton], Lucilia cuprina [Wiedemann], and Hemipyrellia ligurriens [Wiedemann]) and a housefly (Musca domestica L.) revealed that the anterior ends and the profiles of the posterior spiracles had markedly distinguishing characteristics. Morphometric analysis of the length and width of puparia, along with the length of the gaps between the posterior spiracles

  11. The definition of IVM is clear-variations need defining.

    Science.gov (United States)

    De Vos, Michel; Smitz, Johan; Thompson, Jeremy G; Gilchrist, Robert B

    2016-11-01

    Oocyte in vitro maturation (IVM) is currently defined as the maturation in vitro of immature cumulus-oocyte complexes collected from antral follicles. This is the original definition as first described by Pincus and Enzmann and then by Edwards many decades ago, and this clear and unambiguous definition has served us well ever since. In an attempt to clarify apparent differences among clinicians, the following revised definition of IVM was recently proposed: 'The retrieval of oocytes from small and intermediate sized follicles in an ovary before the largest follicle has surpassed 13 mm in mean diameter'. As such, this proposed definition should encompass the use of hCG triggering. To change the clear and long-serving definition of IVM to fit varying clinical practices requires a compelling justification based on solid scientific and clinical grounds. We are of the opinion that the proposed revised definition of IVM is counterintuitive as it includes protocols that are intended to mature oocytes in vivo The proposed definitions are cumbersome and indeed further complicate the situation. It is not scientifically rational to base the definition on follicular size, and the definition ignores the vast corporate knowledge acquired from the many decades and >6000 publications in animal research that universally practices IVM as per the existing definition. Furthermore, such a definition can lead to false results in interpreting the follow-up of children conceived using IVM. Hence, we see no rationale to change the existing definition of IVM. However, we agree that variations on IVM require alternative nomenclature-these definitions need to be intuitive and need to clearly distinguish themselves from the existing long-standing definition of IVM. This would help to clarify the recent confusion within the clinical ART community as to what is and what is not, IVM.

  12. Cerebellar clear cell ependymoma in a 10 year old girl

    Energy Technology Data Exchange (ETDEWEB)

    Thinzar Aye Nyein; Moon, Ah Rim; Hwang, Sun Chul; Hong, Hyun Sook; Lee, A Leum; Chang, Kee Hyun; Kim, Hee Kyung; Chin, Su Sie [Soonchunhyang University Bucheon Hospital, Bucheon (Korea, Republic of); Park, Ji Sang [Soonchunhyang University Gumi Hospital, Gumi (Korea, Republic of)

    2016-01-15

    Clear cell ependymoma (CCE) is a histological rare variant (1–5%) of ependymoma, which is distinguished from other histological subtypes by the presence of fusiform cells arrayed radially around small blood vessels. These alleged perivascular pseudorosettes are significant characteristic features of ependymomas. About 95% of infratentorial ependymomas are found in the fourth ventricle and the remainder occurs as cerebellopontine angle lesions. In previous reports, the cerebellum is found to be a rare location for ependymoma. In this study we report one case of CCE originating from the cerebellar hemisphere, showing unusual morphology on 3T MRI.

  13. Incidentally detected clear cell renal cell carcinoma with rhabdoid differentiation.

    Science.gov (United States)

    Krishnamoorthy, Venkatesh; Gowda, Kiran Krishne; Rao, Raman Narayana

    2016-01-01

    Renal cell carcinoma with rhabdoid differentiation (RCC-R) has an aggressive biologic behavior and poor prognosis. A recent consensus statement of the International Society of Urological Pathology (ISUP) proposed a nucleolar grading system (ISUP grade) for RCC to replace Fuhrman system and recommended reporting the presence of rhabdoid differentiation and considering tumors with rhabdoid differentiation to be ISUP Grade 4. We report a case of incidentally detected clear cell RCC-R in a 52-year-old man. This is one of the earliest cases of RCC-R (pT1b) detected and first such case from Indian subcontinent.

  14. Incidentally detected clear cell renal cell carcinoma with rhabdoid differentiation

    Directory of Open Access Journals (Sweden)

    Venkatesh Krishnamoorthy

    2016-01-01

    Full Text Available Renal cell carcinoma with rhabdoid differentiation (RCC-R has an aggressive biologic behavior and poor prognosis. A recent consensus statement of the International Society of Urological Pathology (ISUP proposed a nucleolar grading system (ISUP grade for RCC to replace Fuhrman system and recommended reporting the presence of rhabdoid differentiation and considering tumors with rhabdoid differentiation to be ISUP Grade 4. We report a case of incidentally detected clear cell RCC-R in a 52-year-old man. This is one of the earliest cases of RCC-R (pT1b detected and first such case from Indian subcontinent.

  15. Clear Cell Adenocarcinoma of the Urethra: Review of the Literature

    Directory of Open Access Journals (Sweden)

    Anthony Kodzo-Grey Venyo

    2015-01-01

    Full Text Available Background. Clear cell adenocarcinoma of the urethra (CCAU is extremely rare and a number of clinicians may be unfamiliar with its diagnosis and biological behaviour. Aims. To review the literature on CCAU. Methods. Various internet databases were used. Results/Literature Review. (i CCAU occurs in adults and in women in the great majority of cases. (ii It has a particular association with urethral diverticulum, which has been present in 56% of the patients; is indistinguishable from clear cell adenocarcinoma of the female genital tract but is not associated with endometriosis; and probably does not arise by malignant transformation of nephrogenic adenoma. (iii It is usually, readily distinguished from nephrogenic adenoma because of greater cytological a-typicality and mitotic activity and does not stain for prostate-specific antigen or prostatic acid phosphatase. (iv It has been treated by anterior exenteration in women and cystoprostatectomy in men and at times by radiotherapy; chemotherapy has rarely been given. (v CCAU is aggressive with low 5-year survival rates. (vi There is no consensus opinion of treatment options that would improve the prognosis. Conclusions. Few cases of CCAU have been reported. Urologists, gynaecologists, pathologists, and oncologists should report cases of CCAU they encounter and enter them into a multicentric trial to determine the best treatment options that would improve the prognosis.

  16. Statistical functions and relevant correlation coefficients of clearness index

    Science.gov (United States)

    Pavanello, Diego; Zaaiman, Willem; Colli, Alessandra; Heiser, John; Smith, Scott

    2015-08-01

    This article presents a statistical analysis of the sky conditions, during years from 2010 to 2012, for three different locations: the Joint Research Centre site in Ispra (Italy, European Solar Test Installation - ESTI laboratories), the site of National Renewable Energy Laboratory in Golden (Colorado, USA) and the site of Brookhaven National Laboratories in Upton (New York, USA). The key parameter is the clearness index kT, a dimensionless expression of the global irradiance impinging upon a horizontal surface at a given instant of time. In the first part, the sky conditions are characterized using daily averages, giving a general overview of the three sites. In the second part the analysis is performed using data sets with a short-term resolution of 1 sample per minute, demonstrating remarkable properties of the statistical distributions of the clearness index, reinforced by a proof using fuzzy logic methods. Successively some time-dependent correlations between different meteorological variables are presented in terms of Pearson and Spearman correlation coefficients, and introducing a new one.

  17. APLIKASI SIX SIGMA PADA PRODUK CLEAR FILE DI PERUSAHAAN STATIONARY

    Directory of Open Access Journals (Sweden)

    Desy Emilasari

    2007-01-01

    Full Text Available This paper describes the application of the Six Sigma methods is used in order to improve quality in manufacturing company that produce stationary product. DMAIC approach is utilized to analyze and improve 'Pocket Clear File' product since this product has more variability and defects. Quality improvement also monitor the process that influenced pocket defect in Bag Making, Kami-ire, Karidome, and Pocket after Karidome Inspections section. Determining of Six Sigma project is based in process and defect type in each section. FMEA also gave the recommendation for quality improvement we need to evaluate the final result of the improvement since some of them were not working properly. Abstract in Bahasa Indonesia : Paper ini menggambarkan bagaimana aplikasi metode Six Sigma digunakan untuk melakukan perbaikan kualitas pada perusahaan manufaktur yang memproduksi produk stationary. Pendekatan DMAIC dipakai untuk menganalisa dan melakukan perbaikan produk 'Pocket Clear File' karena tingginya variabilitas dan cacat dibanding produk lain. Perbaikan kualitas juga memperhatikan proses yang mempengaruhi terjadinya cacat pocket pada section Bag Making, Kami-ire, Karidome, dan Pocket after Karidome Inspection. Penentuan proyek Six Sigma didasarkan atas proses dan jenis cacat pada setiap section. Pendekatan FMEA mampu memberi rekomendasi perbaikan kualitas. Evaluasi dari hasil perbaikan penting untuk dilakukan karena beberapa implementasi perbaikan kualitas tidak berjalan sesuai dengan rencana. kata kunci: six sigma, DMAIC, perusahaan stationary.

  18. Primary abdominal wall clear cell carcinoma arising from incisional endometriosis

    Institute of Scientific and Technical Information of China (English)

    Burcu Gundogdu; Isin Ureyen; Gunsu Kimyon; Hakan Turan; Nurettin Boran; Gokhan Tulunay; Dilek Bulbul; Taner Turan; M Faruk Kose

    2013-01-01

    A 49 year-old patient with the complaint of a mass located in the caesarean scar was admitted. There was a fixed mass 30í30 mm in diameter with regular contour located at the right corner of the pfannenstiel incision. Computed tomography revealed a (40í50í50) mm solid mass lesion with margins that cannot be distinguished from the uterus, bladder and small intestines and a heterogeneous mass lesion (50í45í55) mm in diameter, located in the right side of the anterior abdominal wall. Cytoreductive surgery including total abdominal hysterectomy and bilateral salpingo-oophorectomy was performed. Final pathology was clear cell carcinoma. Clear cell carcinoma arising from an extraovarian endometriotic focus was diagnosed and the patient received 6 cycles paclitaxel-carboplatin chemotherapy as adjuvant treatment. The patient who was lost to follow-up applied to our clinic 2 years after surgery with a recurrent mass in the left inguinal region. After 3 cycles of chemotherapy, the patient's tumoral mass in the left inguinal region was excised. The result of the pathology was carcinoma metastasis. It is decided that the following treatment of the patient should be palliative radiation therapy. The patient who underwent palliative radiation therapy died of disease after 4 months of the second operation.

  19. Code Generation for Embedded Software for Modeling Clear Box Structures

    Directory of Open Access Journals (Sweden)

    V. Chandra Prakash

    2011-09-01

    Full Text Available Cleanroom software Engineering (CRSE recommended that the code related to the Application systems be generated either manually or through code generation models or represents the same as a hierarchy of clear box structures. CRSE has even advocated that the code be developed using the State models that models the internal behavior of the systems. No framework has been recommended by any Author using which the Clear boxes are designed using the code generation methods. Code Generation is one of the important quality issues addressed in cleanroom software engineering. It has been investigated that CRSE can be used for life cycle management of the embedded systems when the hardware-software co-design is in-built as part and parcel of CRSE by way of adding suitable models to CRSE and redefining the same. The design of Embedded Systems involves code generation in respect of hardware and Embedded Software. In this paper, a framework is proposed using which the embedded software is generated. The method is unique that it considers various aspects of the code generation which includes Code Segments, Code Functions, Classes, Globalization, Variable propagation etc. The proposed Framework has been applied to a Pilot project and the experimental results are presented.

  20. MODIS Observations of Enhanced Clear Sky Reflectance Near Clouds

    Science.gov (United States)

    Varnai, Tamas; Marshak, Alexander

    2009-01-01

    Several recent studies have found that the brightness of clear sky systematically increases near clouds. Understanding this increase is important both for a correct interpretation of observations and for improving our knowledge of aerosol-cloud interactions. However, while the studies suggested several processes to explain the increase, the significance of each process is yet to be determined. This study examines one of the suggested processes three-dimensional (3-D) radiative interactions between clouds and their surroundings by analyzing a large dataset of MODIS (Moderate Resolution Imaging Spectroradiometer) observations over the Northeast Atlantic Ocean. The results indicate that 3-D effects are responsible for a large portion of the observed increase, which extends to about 15 km away from clouds and is stronger (i) at shorter wavelengths (ii) near optically thicker clouds and (iii) near illuminated cloud sides. This implies that it is important to account for 3-D radiative effects in the interpretation of solar reflectance measurements over clear regions in the vicinity of clouds.

  1. Genetic characteristics of the non-clear cell renal cancer

    Directory of Open Access Journals (Sweden)

    D. S. Mikhaylenko

    2016-01-01

    Full Text Available Renal cancer (RC is one of the most frequent diseases in oncological urology; the most common form of RC is the clear cell carcinoma. However, percentage of less-studied non-clear cell RC (nccRC reaches up to 25 % of cases suggesting further studying, improvement of diagnosis and treatment of these tumors. The key events of carcinogenesis are genetic alterations including chromosomal aberrations and point mutations in proto-oncogenes and tumor suppressor genes. This review describes cytogenetic aberrations in the context of nccRC diversity according to the current ISUP classification. Translocation variants of nccRC (MiT-RC were characterized separately as particular cases of the chromosome rearrangements involving MiT gene family (TFE3, TFEB, MITF. In addition, the main nccRC hereditary forms caused by germinal mutations in the genes FLCN, FH, and MET, as well as recent studies of sporadic tumors with using the next generation sequencing techniques were reviewed. These experiments were designed to search for somatic mutations throughout the tumor genome or exom and revealed the different mutational profiles of I/II papillary RC subtypes, chromophobe carcinoma versus oncocytoma. The review may be informative for oncologists, urologists, geneticists and specialists in related sciences. 

  2. Use of Digital Image Technology to 'Clearly' Depict Global Change

    Science.gov (United States)

    Molnia, B. F.; Carbo, C. L.

    2014-12-01

    Earth is dynamic and beautiful. Understanding why, when, how, and how fast its surface changes yields information and serves as a source of inspiration. The artistic use of geoscience information can inform the public about what is happening to their planet in a non-confrontational and apolitical way. While individual images may clearly depict a landscape, photographic comparisons are necessary to clearly capture and display annual, decadal, or century-scale impacts of climate and environmental change on Earth's landscapes. After years of effort to artistically communicate geoscience concepts with unenhanced individual photographs or pairs of images, the authors have partnered to maximize this process by using digital image enhancement technology. This is done, not to manipulate the inherent artistic content or information content of the photographs, but to insure that the comparative photo pairs produced are geometrically correct and unambiguous. For comparative photography, information-rich historical photographs are selected from archives, websites, and other sources. After determining the geographic location from which the historical photograph was made, the original site is identified and eventually revisited. There, the historical photos field of view is again photographed, ideally from the original location. From nearly 250 locations revisited, about 175 pairs have been produced. Every effort is made to reoccupy the original historical site. However, vegetation growth, visibility reduction, and co-seismic level change may make this impossible. Also, inherent differences in lens optics, camera construction, and image format may result in differences in the geometry of the new photograph when compared to the old. Upon selection, historical photos are cleaned, contrast stretched, brightness adjusted, and sharpened to maximize site identification and information extraction. To facilitate matching historical and new images, digital files of each are overlain in

  3. Temporal co-registration for TROPOMI cloud clearing

    Directory of Open Access Journals (Sweden)

    I. Genkova

    2011-10-01

    Full Text Available The TROPOspheric Monitoring Instrument (TROPOMI is planed for launch in 2014 on board of the Sentinel 5 Precursor (S5P and is anticipated to provide high-quality and timely information on the global atmospheric composition for climate and air quality applications. TROPOMI will observe key atmospheric constituents such as ozone, nitrogen dioxide, sulfur dioxide, carbon monoxide, methane, formaldehyde and aerosol properties. The retrieval algorithms for the anticipated products require cloud information on a pixel basis. Most of them will use the cloud properties derived from TROPOMI's own measurements, such as the O2 A-band measurements. However, the methane and the aerosol retrievals require very precise cloud clearing, which is difficult to achieve at the TROPOMI spatial resolution (7 × 7 km2 and without thermal IR measurements. The current payload of the Sentinel 5 Precursor (S-5P does not include a cloud imager, thus it is planned to fly the S5P mission in a constellation with another instrument yielding an accurate cloud mask. The cloud imagery data will be provided by the US NPOESS Preparatory Project (NPP mission which will have the Visible Infrared Imager Radiometer Suite (VIIRS on board (Scalione, 2004. VIIRS will have 22 bands in the VIS and IR spectral ranges, and will deliver data with two spatial resolutions: imagery resolution bands with a nominal pixel size of 370 m at nadir, and moderate resolution bands with nominal pixel size 740 m at nadir. The instrument is combining fine spatial resolution with high-accuracy calibration similar or superior to AVHRR.

    This paper presents results from investigating the temporal co-registration requirements for suitable time differences between the VIIRS measurements of clouds and the TROPOMI methane and aerosol measurements, so that the former could be used for cloud clearing. The temporal co-registration is studied using Meteosat Second Generation (MSG Spinning

  4. Proposal for a project agreement with ISTC - Crystal Clear Collaboration

    CERN Document Server

    2001-01-01

    This document concerns a project agreement with the ISTC entitled "Development of the Detector Production Technology for a New Generation of Positron Emission Tomographs to be used in Medecine and Pharmacology" to be executed in co-operation with the Crystal Clear Collaboration. For the reasons set out in this document, the Finance Committee is invited to agree to the negotiation of a project agreement with ISTC for a total amount of 775 000 US dollars. The European Union party in ISTC will co-fund the project up to a total of 525 000 US dollars. CERN's contribution will not exceed 250 000 US dollars. At the present rate of exchange this is equivalent to approximately 430 000 Swiss francs

  5. All-clear for gourmets: truffles not radioactive

    Science.gov (United States)

    Büntgen, U.; Jäggi, M.; Stobbe, U.; Tegel, W.; Sproll, L.; Eikenberg, J.; Egli, S.

    2016-02-01

    Although ranging among the most expensive gourmet foods, it remains unclear whether Burgundy truffles (Tuber aestivum) accumulate radioactivity at a harmful level comparable to other fungal species. Here, we measure the 137Cs in 82 T. aestivum fruit bodies from Switzerland, Germany, France, Italy, and Hungary. All tested specimens reveal insignificant radiocaesium concentrations, thus providing an all-clear for many truffle hunters and cultivators in large parts of Europe as well as the subsequent chain of dealers and customers from around the world. Our results are particularly relevant in the light of ongoing efforts to cultivate Burgundy truffles, as well as the fact that several forest ecosystems are still highly contaminated with 137Cs, for which mushrooms are one of the main pathways to human diets.

  6. Impacts of roads and linear clearings on tropical forests.

    Science.gov (United States)

    Laurance, William F; Goosem, Miriam; Laurance, Susan G W

    2009-12-01

    Linear infrastructure such as roads, highways, power lines and gas lines are omnipresent features of human activity and are rapidly expanding in the tropics. Tropical species are especially vulnerable to such infrastructure because they include many ecological specialists that avoid even narrow (forest edges, as well as other species that are susceptible to road kill, predation or hunting by humans near roads. In addition, roads have a major role in opening up forested tropical regions to destructive colonization and exploitation. Here, we synthesize existing research on the impacts of roads and other linear clearings on tropical rainforests, and assert that such impacts are often qualitatively and quantitatively different in tropical forests than in other ecosystems. We also highlight practical measures to reduce the negative impacts of roads and other linear infrastructure on tropical species.

  7. The palm oil supply chain, deforestation and peat clearing

    Science.gov (United States)

    Boucher, D. H.

    2013-12-01

    The palm oil industry has expanded rapidly in the last two decades, particularly in Indonesia. A considerable amount of this expansion has been at the expense of forests and peatlands, resulting in considerable greenhouse gas emissions. Now the industry is faced with two new challenges. There is a possible oversupply on the global market due to recent expansion and the time lag between clearing and new production coming on line, which may depress prices considerably. Furthermore, there is increasing pressure to reduce the industry's impact on climate and biodiversity, exemplified by the commitment by the businesses of the Consumer Goods Forum to eliminate deforestation from their supply chains by 2020. This presentation will examine the interaction between these two challenges and its implications for the industry, in both southeast Asia and new regions of expansion, and how this interaction could transform the industry's mode of expansion in the coming decade.

  8. Short imidazolium chains effectively clear fungal biofilm in keratitis treatment.

    Science.gov (United States)

    Liu, Lihong; Wu, Hong; Riduan, Siti Nurhanna; Ying, Jackie Y; Zhang, Yugen

    2013-01-01

    Fungal keratitis is a leading cause of ocular morbidity throughout the world. However, current therapies against fungal keratitis are often ineffective. Herein, we have developed the amphiphilic main-chain imidazolium polymer (PIM-45) and oligomer (IBN-1) materials that can efficiently inhibit the growth of fungi with low minimal inhibition concentration (MIC) values and clear the fungal biofilm, while displaying minimal hemolysis. In vivo keratitis treatment indicates that topical solutions of these polyimidazolium salts (PIMSs) are safe and as effective as that of amphotericin B, the most commonly used agent for the treatment of Candida albicans (C. albicans) keratitis. Compared to the costly and unstable amphotericin B and fluconazole, PIM-45 and IBN-1 are easy to prepare, inexpensive and stable. They can be stored in phosphate-buffered saline (PBS) solutions with long shelf life for routine topical use.

  9. Temporal variation of clear-water scour at compound Abutments

    Directory of Open Access Journals (Sweden)

    Aminuddin Ab. Ghani

    2016-12-01

    Full Text Available Most of actual abutments in rivers are built on foundation, while there is limited number of study available on the effects of the foundation on the local scour. In this study, temporal variation of local scour around compound abutment was investigated experimentally under clear-water conditions. The results showed that a suitable level of foundation is able to decrease the scour depth and increase scour time during the flood events. The trend of temporal scour depth at compound pier and abutment is similar. The scour depth develops to top of foundation quickly, and then the foundation postpones the scour development (lag–time. Duration of lag–time depends on the foundation level, velocity ratio (U/Uc and foundation dimension. This study highlights that proper design of foundation level increases duration of scouring and provides enough time to treat bridge foundation after the flood events.

  10. Renal Clear Cell Sarcoma - Anaplastic Variant: A Rare Entity.

    Science.gov (United States)

    Walke, Vaishali Atmaram; Shende, Nitin Y; Kumbhalkar, D T

    2017-01-01

    Clear Cell Sarcoma of Kidney (CCSK) is known for its morphologic diversity, aggressive behaviour, tendency to recur and metastasis to bone. Amongst the various morphologic subtypes, anaplastic CCSK is associated with worse prognosis. Here, we report a case of this rare variant of CCSK. A five-year-old boy presented with history of lump and pain in abdomen since one week. The Computed Tomography (CT) scan revealed a large mass occupying the middle and inferior pole of right kidney. The clinical impression was Wilms tumour. Nephrectomy specimen was received and the diagnosis of CCSK anaplastic variant was offered only after excluding the differentials and after performing ancillary tests such as Immunohistochemistry (IHC). Thus, this case emphasizes the diagnostic challenges on morphology and the essential role of IHC in arriving at a definitive diagnosis, because failure to do so may deprive the child from optimal treatment.

  11. A Qualitative and Quantitative Evaluation of 8 Clear Sky Models.

    Science.gov (United States)

    Bruneton, Eric

    2016-10-27

    We provide a qualitative and quantitative evaluation of 8 clear sky models used in Computer Graphics. We compare the models with each other as well as with measurements and with a reference model from the physics community. After a short summary of the physics of the problem, we present the measurements and the reference model, and how we "invert" it to get the model parameters. We then give an overview of each CG model, and detail its scope, its algorithmic complexity, and its results using the same parameters as in the reference model. We also compare the models with a perceptual study. Our quantitative results confirm that the less simplifications and approximations are used to solve the physical equations, the more accurate are the results. We conclude with a discussion of the advantages and drawbacks of each model, and how to further improve their accuracy.

  12. Clear cell chondrosarcoma mimicking chondroblastoma in a skeletally immature patient

    Energy Technology Data Exchange (ETDEWEB)

    Cannon, Christopher P. [Department of Orthopaedic Surgery, Madigan Army Medical Center, Ft. Lewis, WA (United States); Nelson, Scott D. [Department of Pathology and Laboratory Medicine, University of California, Los Angeles School of Medicine, CA (United States); Seeger, Leanne L. [Department of Radiological Sciences, University of California, CA (United States); Eckardt, Jeffrey J. [Department of Orthopaedic Surgery, University of California, Los Angeles School of Medicine, CA (United States)

    2002-06-01

    We report the case of a clear cell chondrosarcoma (CCCS) occurring in the femoral head of a 14-year-old skeletally immature boy. Radiographic examination revealed a well-defined, osteolytic lesion in the epiphysis of the femoral head. Given the patient's age and the radiographic appearance of the lesion, chondroblastoma was high on the differential diagnosis. A frozen section was performed at the time of open biopsy was felt to be consistent with either chondroblastoma or CCCS. CCCS in a skeletally immature patient was felt to be unlikely, so curettage and bone grafting was performed. Final pathology review, however, confirmed the diagnosis of CCCS. The patient was taken back to surgery 4 weeks later for a wide resection and hemiarthroplasty. (orig.)

  13. Electricity market clearing with improved dispatch of stochastic production

    DEFF Research Database (Denmark)

    Morales González, Juan Miguel; Zugno, Marco; Pineda, Salvador;

    2014-01-01

    In this paper, we consider an electricity market that consists of a day-ahead and a balancing settlement, and includes a number of stochastic producers. We first introduce two reference procedures for scheduling and pricing energy in the day-ahead market: on the one hand, a conventional network......-constrained auction purely based on the least-cost merit order, where stochastic generation enters with its expected production and a low marginal cost; on the other, a counterfactual auction that also accounts for the projected balancing costs using stochastic programming. Although the stochastic clearing procedure...... attains higher market efficiency in expectation than the conventional day-ahead auction, it suffers from fundamental drawbacks with a view to its practical implementation. In particular, it requires flexible producers (those that make up for the lack or surplus of stochastic generation) to accept losses...

  14. Use of clear lake as standard reflectors for atmospheric measurement

    Science.gov (United States)

    Ahern, F. J.; Goodenough, D. G.; Jain, S. C.; Rao, V. R.; Rochon, G.

    1977-01-01

    A method is proposed for using clear lakes as dark backgrounds against which the atmospheric path radiance can be determined from satellite observations. If the path radiance can be determined to sufficient accuracy, the atmospheric extinction can be inferred with suitable radiative transfer models. An extensive program of observation was made to determine the magnitude and variability of the various contributors to the total radiance observed by a satellite. It is shown that the volume and surface reflectance contributions (in the absence of sunglint) are small, constant, and can be modeled accurately enough to make these an insignificant source of error. The sunglint radiance observed in this investigation may be a significant source of error. It is shown that atmospheric extinction can be inferred from the path radiance observation after systematic differences between the model and observations are removed.

  15. Clear Cell Adenocarcinoma Arising from Abdominal Wall Endometriosis

    Directory of Open Access Journals (Sweden)

    Thouraya Achach

    2008-01-01

    Full Text Available Endometriosis is a frequent benign disorder. Malignancy arising in extraovarian endometriosis is a rare event. A 49-year-old woman is presented with a large painful abdominal wall mass. She underwent a myomectomy, 20 years before, for uterus leiomyoma. Computed tomography suggested that this was a desmoid tumor and she underwent surgery. Histological examination showed a clear cell adenocarcinoma associated with endometriosis foci. Pelvic ultrasound, computed tomography, and endometrial curettage did not show any malignancy or endometriosis in the uterus and ovaries. Adjuvant chemotherapy was recommended, but the patient was lost to follow up. Six months later, she returned with a recurrence of the abdominal wall mass. She was given chemotherapy and then she was reoperated.

  16. Estimation of clear sky hourly global solar radiation in Iraq

    Energy Technology Data Exchange (ETDEWEB)

    Al-Jumaily, Kais J.; Al-Zuhairi, Munya F.; Mahdi, Zahraa S. [Department of Atmospheric Sciences, College of Science, Al-Mustansiriyah University, Baghdad (Iraq)

    2012-07-01

    The availability of hourly solar radiation data is very important for applications utilizing solar energy and for climate and environmental aspects. The aim of this work is to use a simple model for estimating hourly global solar radiation under clear sky condition in Iraq. Calculations were compared with measurements obtained from local station in Baghdad city and from Meteosat satellite data for different locations in Iraq. The statistical test methods of the mean bias error (MBE), root mean square error (RMSE) and t-test were used to evaluate the performance of the model. Results indicated that a fairly good agreement exists between calculated and measured values for all locations in Iraq. Since the model is independent of any meteorological variable, it would be of a practical use for rural areas where no meteorological data are available.

  17. Estrategia de redes sociales para la marca Clean&Clear

    OpenAIRE

    González Alzáibar, Gabriela

    2014-01-01

    Aquest treball és una proposta d'estratègia de xarxes socials per la marca Clean&Clear, que pertany al grup Johnson&Johnson. El treball constitueix una estratègia que té en compte tots els aspectes rellevants, per tant, es podria aplicar de forma immediata. Amb la intenció de dissenyar aquesta estratègia, s'analitza la situació actual de la marca a l'entorn social, així com la situació de la seva competència. Posteriorment, s’estudia el target i la penetració de les xarxes socials a Espanya p...

  18. Temperature gradients and clear-air turbulence probabilities

    Science.gov (United States)

    Bender, M. A.; Panofsky, H. A.; Peslen, C. A.

    1976-01-01

    In order to forecast clear-air turbulence (CAT) in jet aircraft flights, a study was conducted in which the data from a special-purpose instrument aboard a Boeing 747 jet airliner were compared with satellite-derived radiance gradients, conventional temperature gradients from analyzed maps, and temperature gradients obtained from a total air temperature sensor on the plane. The advantage of making use of satellite-derived data is that they are available worldwide without the need for radiosonde observations, which are scarce in many parts of the world. Major conclusions are that CAT probabilities are significantly higher over mountains than flat terrain, and that satellite radiance gradients appear to discriminate between CAT and no CAT better than conventional temperature gradients over flat lands, whereas the reverse is true over mountains, the differences between the two techniques being not large over mountains.

  19. Endogenous Market-Clearing Prices and Reference Point Adaptation

    Science.gov (United States)

    Dragicevic, Arnaud Z.

    When prices depend on the submitted bids, i.e. with endogenous market-clearing prices in repeated-round auction mechanisms, the assumption of independent private values that underlines the property of incentive-compatibility is to be brought into question; even if these mechanisms provide active involvement and market learning. In its orthodox view, adaptive bidding behavior imperils incentive-compatibility. We relax the assumption of private values' independence in the repeated-round auctions, when the market-clearing prices are made public at the end of each round. Instead of using game-theory learning models, we introduce a behavioral model that shows that bidders bid according to the anchoring-and-adjustment heuristic, which neither ignores the rationality and incentive-compatibility constraints, nor rejects the posted prices issued from others' bids. Bidders simply weight information at their disposal and adjust their discovered value using reference points encoded in the sequential price weighting function. Our model says that bidders and offerers are sincere boundedly rational utility maximizers. It lies between evolutionary dynamics and adaptive heuristics and we model the concept of inertia as high weighting of the anchor, which stands for truthful bidding and high regard to freshly discovered preferences. Adjustment means adaptive rule based on adaptation of the reference point in the direction of the posted price. It helps a bidder to maximize her expected payoff, which is after all the only purpose that matters to rationality. The two components simply suggest that sincere bidders are boundedly rational. Furthermore, by deviating from their anchor in the direction of the public signal, bidders operate in a correlated equilibrium. The correlation between bids comes from the commonly observed history of play and each bidder's actions are determined by the history. Bidders are sincere if they have limited memory and confine their reference point adaptation

  20. Childhood to adolescence: dust and gas clearing in protoplanetary disks

    Science.gov (United States)

    Brown, Joanna Margaret

    Disks are ubiquitous around young stars. Over time, disks dissipate, revealing planets that formed hidden by their natal dust. Since direct detection of young planets at small orbital radii is currently impossible, other tracers of planet formation must be found. One sign of disk evolution, potentially linked to planet formation, is the opening of a gap or inner hole in the disk. In this thesis, I have identified and characterized several cold disks with large inner gaps but retaining massive primordial outer disks. While cold disks are not common, with ~5% of disks showing signs of inner gaps, they provide proof that at least some disks evolve from the inside-out. These large gaps are equivalent to dust clearing from inside the Earth's orbit to Neptune's orbit or even the inner Kuiper belt. Unlike more evolved systems like our own, the central star is often still accreting and a large outer disk remains. I identified four cold disks in Spitzer 5-40 μm spectra and modeled these disks using a 2-D radiative transfer code to determine the gap properties. Outer gap radii of 20-45 AU were derived. However, spectrophotometric identification is indirect and model-dependent. To validate this interpretation, I observed three disks with a submillimeter interferometer and obtained the first direct images of the central holes. The images agree well with the gap sizes derived from the spectrophotometry. One system, LkH&alpha 330, has a very steep outer gap edge which seems more consistent with gravitational perturbation rather than gradual processes, such as grain growth and settling. Roughly 70% of cold disks show CO v=1&rarr 0 gas emission from the inner 1 AU and therefore are unlikely to have evolved due to photoevaporation. The derived rotation temperatures are significantly lower for the cold disks than disks without gaps. Unresolved (sub)millimeter photometry shows that cold disks have steeper colors, indicating that they are optically thin at these wavelengths, unlike

  1. Clearing the way for reducing emissions from tropical deforestation

    Energy Technology Data Exchange (ETDEWEB)

    Skutsch, M. [Department of Technology and Sustainable Development, University of Twente, P.O. Box 217, 7500 AE Enschede (Netherlands); Bird, N. [Joanneum Research, Elizabethstrasse 5/1, A-8010 Graz (Austria); Trines, E. [Gramserweg 2, 3711 AW Austerlitz (Netherlands); Dutschke, M. [Biocarbon, Badstrasse 41, 77652 Offenburg (Germany); Frumhoff, P. [Union of Concerned Scientists, 2 Brattle Square, Cambridge, MA 02238-9105 (United States); De Jong, B.H.J. [El Colegio de la Frontera Sur, Unidad Villahermosa, Carr. Vhsa-Reforma Km. 15.5, C.P. 86280, Ra Guineo 2da Secc, Villahermosa, Tabasco (Mexico); Van Laak, P. [ITC, Department of Natural Resources, P.O. Box 6, 7500 AA Enschede (Netherlands); Masera, O. [Centro de Investigaciones en Ecosistemas, UNAMAP 27-3 Xangari 58089, Morelia, Michoacan (Mexico); Murdiyarso, D. [Center for International Forestry Research, Jl. CIFOR, Situ Gede Sindangbarang, Bogor 16680 (Indonesia)

    2007-06-15

    Carbon emissions from tropical deforestation account for about 25% of all anthropogenic carbon dioxide emissions but cannot be credited under current climate change agreements. In the discussions around the architecture of the post-2012 climate regime, the possibility of including credits for reduced emissions from deforestation arises. The paper reviews two approaches for this, compensated reductions (CR) as proposed by Santilli et al. and the Joint Research Centre proposal that combine voluntary commitments by non-Annex I countries to reduce emissions from deforestation with carbon market financing. Both approaches have the clear advantages of simplicity and the possibility of fitting to an evolving greenhouse gas emission reduction regime. The authors consider the strengths and limitations of each proposal and build upon them to address several implementation challenges and options for improvement. Given the urgency of avoiding dangerous climate change, the timely development of technically sound, politically acceptable, cost-effective and practicable measures to reduce emissions from deforestation and forest degradation is essential. These two approaches take us a step closer to this goal, but they need to be refined rapidly to enable this goal to be realised.

  2. A crystal-clear zebrafish for in vivo imaging.

    Science.gov (United States)

    Antinucci, Paride; Hindges, Robert

    2016-01-01

    The larval zebrafish (Danio rerio) is an excellent vertebrate model for in vivo imaging of biological phenomena at subcellular, cellular and systems levels. However, the optical accessibility of highly pigmented tissues, like the eyes, is limited even in this animal model. Typical strategies to improve the transparency of zebrafish larvae require the use of either highly toxic chemical compounds (e.g. 1-phenyl-2-thiourea, PTU) or pigmentation mutant strains (e.g. casper mutant). To date none of these strategies produce normally behaving larvae that are transparent in both the body and the eyes. Here we present crystal, an optically clear zebrafish mutant obtained by combining different viable mutations affecting skin pigmentation. Compared to the previously described combinatorial mutant casper, the crystal mutant lacks pigmentation also in the retinal pigment epithelium, therefore enabling optical access to the eyes. Unlike PTU-treated animals, crystal larvae are able to perform visually guided behaviours, such as the optomotor response, as efficiently as wild type larvae. To validate the in vivo application of crystal larvae, we performed whole-brain light-sheet imaging and two-photon calcium imaging of neural activity in the retina. In conclusion, this novel combinatorial pigmentation mutant represents an ideal vertebrate tool for completely unobstructed structural and functional in vivo investigations of biological processes, particularly when imaging tissues inside or between the eyes.

  3. Clear antismudge unimolecular coatings of diblock copolymers on glass plates.

    Science.gov (United States)

    Macoretta, Danielle; Rabnawaz, Muhammad; Grozea, Claudia M; Liu, Guojun; Wang, Yu; Crumblehulme, Alison; Wyer, Martin

    2014-12-10

    Two poly[3-(triisopropyloxysilyl)propyl methacrylate]-block-poly[2-(perfluorooctyl)ethyl methacrylate] (PIPSMA-b-PFOEMA) samples and one poly(perfluoropropylene oxide)-block-poly-[3-(triisopropyloxysilyl)propyl methacrylate] (PFPO-b-PIPSMA) sample were synthesized, characterized, and used to coat glass plates. These coatings were formed by evaporating a dilute polymer solution containing HCl, which catalyzed PIPSMA's sol-gel chemistry. Polymer usage was minimized by targeting at diblock copolymer unimolecular (brush) layers that consisted of a sol-gelled grafted PIPSMA layer and an oil- and water-repellant fluorinated surface layer. Investigated is the effect of varying the catalyst amount, polymer amount, as well as block copolymer type and composition on the structure, morphology, and oil- and water-repellency of the coatings. Under optimized conditions, the prepared coatings were optically clear and resistant to writing by a permanent marker. The marker's trace was the faintest on PFPO-b-PIPSMA coatings. In addition, the PFPO-b-PIPSMA coatings were far more wear-resistant than the PIPSMA-b-PFOEMA coatings.

  4. Energy Efficient Clear Channel Assessment for LR-WPAN

    Directory of Open Access Journals (Sweden)

    Praveen Kaushik

    2011-05-01

    Full Text Available IEEE 802.15.4 LR-WPAN is a specification for low-cost, low-powered and low data rate transmission. This standard uses CSMA/CA protocol for contention resolution. One of the tasks performed by CSMA/CA algorithm is Clear Channel Assessment (CCA, used to find the status (IDLE or BUSY of the channel. There are three operating modes to perform CCA. As per the standard CCA mode 2 and 3 are based on carrier sensing where as CCA mode 1 is based on Energy Detection Threshold (EDThreshold. CCA in most of the WPAN is based on carrier sense. EDThreshold dependent CCA mode 1 is more advantageous in case of energy constraint networks, as minimum energy is consumed in channel allocation using EDThreshold. This property of EDThreshold is utilized in CCA for LR- WPAN and is implemented in NS2. Simulation results of EDThreshold based mode 1 CCA indicate that number of packets dropped decreases, network as well as node throughput increases and energy consumption is also less when compared to Carrier Sense Threshold (CSThreshold based mode 1 CCA. It is also observed from the results that MAC_PACKET_ERROR is also acceptable, that is, less than 1%.

  5. Clearing Unexploded Ordnance: Bayesian Methodology for Assessing Success

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, K K.

    2005-10-30

    The Department of Defense has many Formerly Used Defense Sites (FUDS) that are slated for transfer for public use. Some sites have unexploded ordnance (UXO) that must be cleared prior to any land transfers. Sites are characterized using geophysical sensing devices and locations are identified where possible UXO may be located. In practice, based on the analysis of the geophysical surveys, a dig list of N suspect locations is created for a site that is possibly contaminated with UXO. The suspect locations on the dig list are often assigned into K bins ranging from ``most likely to contain UXO" to ``least likely to be UXO" based on signal discrimination techniques and expert judgment. Usually all dig list locations are sampled to determine if UXO is present before the site is determined to be free of UXO. While this method is 100% certain to insure no UXO remains in the locations identified by the signal discrimination and expert judgment, it is very costly. This paper proposes a statistical Bayesian methodology that may result in digging less than 100% of the suspect locations to reach a pre-defined tolerable risk, where risk is defined in terms of a low probability that any UXO remains in the unsampled dig list locations. Two important features of a Bayesian approach are that it can account for uncertainties in model parameters and that it can handle data that becomes available in stages. The results from each stage of data can be used to direct the subsequent digs.

  6. Hemosiderotic clear-cell acanthoma: A pigmented mimicker

    Directory of Open Access Journals (Sweden)

    Leonardo Bugatti

    2011-01-01

    Full Text Available The authors report on a case of a 65-year-old man with pigmented clear-cell acanthoma located on the right thigh. Dermoscopy disclosed a peculiar picture consisting of diffuse black pigmentation with a superficial greyish veil in the central portion, dotted-to-globular dark red-black structures mainly located at the periphery with a homogenous regular reticular arrangement; peripheral translucid desquamation. Dermoscopic features are correlated with the histology, where hemosiderin deposits present in a sheet-like arrangement in the perivascular papillary dermis and in a band-like disposition in the reticular dermis at the base of the lesion can account for the pigmented picture. The lesion arose on a trauma-prone skin site; thus the authors believe that traumatic irritation may be responsible for the clinical and dermoscopic pictures, giving rise to a reaction similar in a way to the Auspitz′s sign provocated by trauma for psoriasis. Red blood cells extravasation from extremely superficialized capillaries may have led to hemosiderin deposition in the papillary and the reticular dermis.

  7. Bridge Pressure Flow Scour at Clear Water Threshold Condition

    Institute of Scientific and Technical Information of China (English)

    GUO Junke; KERENYI Kornel; PAGAN-ORTIZ Jorge E; FLORA Kevin

    2009-01-01

    Bridge pressure flow scour at clear water threshold condition is studied theoretically and experimentally. The flume experiments reveal that the measured scour profiles under a bridge are more or less 2-dimensional; all the measured scour profiles can be described by two similarity equations, where the horizontal distance is scaled by the deck width while the local scour by the maximum scour depth; the maximum scour position is located just under the bridge about 15% deck width from the downstream deck edge; the scour begins at about one deck width upstream the bridge while the deposition occurs at about 2.5 deck widths downstream the bridge; and the maximum scour depth decreases with increas-ing sediment size, but increases with deck inundation. The theoretical analysis shows that: bridge scour can be divided into three cases, i.e. downstream unsubmerged, partially submerged, and totally submerged. For downstream unsubmerged flows, the maximum bridge scour depth is an open-channel problem where the conventional methods in terms of critical velocity or bed shear stress can be applied; for partially and totally submerged flows, the equilibrium maximum scour depth can be described by a scour and an inundation similarity number, which has been confirmed by experiments with two decks and two sediment sizes. For application, a design and field evaluation procedure with examples is presented, including the maximum scour depth and scour profile.

  8. NOAA AVHRR Clear-Sky Products over Oceans (ACSPO): Sea Surface Temperature, Clear Sky Radiances, and Aerosol Optical Depth for the Global Ocean, 2011 - present (NCEI Accession 0072979)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The AVHRR Clear-Sky Processor over Oceans, jointly developed between NESDIS STAR and OSDPD, produces AVHRR clear-sky products over oceans. ACSPO generates output...

  9. DISCRIMINATING BETWEEN CLOUDY, HAZY, AND CLEAR SKY EXOPLANETS USING REFRACTION

    Energy Technology Data Exchange (ETDEWEB)

    Misra, Amit K.; Meadows, Victoria S. [Astronomy Department, University of Washington, Seattle, WA 98195 (United States)

    2014-11-01

    We propose a method to distinguish between cloudy, hazy, and clear sky (free of clouds and hazes) exoplanet atmospheres that could be applicable to upcoming large aperture space- and ground-based telescopes such as the James Webb Space Telescope (JWST) and the European Extremely Large Telescope (E-ELT). These facilities will be powerful tools for characterizing transiting exoplanets, but only after a considerable amount of telescope time is devoted to a single planet. A technique that could provide a relatively rapid means of identifying haze-free targets (which may be more valuable targets for characterization) could potentially increase the science return for these telescopes. Our proposed method utilizes broadband observations of refracted light in the out-of-transit spectrum. Light refracted through an exoplanet atmosphere can lead to an increase of flux prior to ingress and subsequent to egress. Because this light is transmitted at pressures greater than those for typical cloud and haze layers, the detection of refracted light could indicate a cloud- or haze-free atmosphere. A detection of refracted light could be accomplished in <10 hr for Jovian exoplanets with JWST and <5 hr for super-Earths/mini-Neptunes with E-ELT. We find that this technique is most effective for planets with equilibrium temperatures between 200 and 500 K, which may include potentially habitable planets. A detection of refracted light for a potentially habitable planet would strongly suggest the planet was free of a global cloud or haze layer, and therefore a promising candidate for follow-up observations.

  10. Gene expression profile of renal cell carcinoma clear cell type

    Directory of Open Access Journals (Sweden)

    Marcos F. Dall’Oglio

    2010-08-01

    Full Text Available PURPOSE: The determination of prognosis in patients with renal cell carcinoma (RCC is based, classically, on stage and histopathological aspects. The metastatic disease develops in one third of patients after surgery, even in localized tumors. There are few options for treating those patients, and even the new target designed drugs have shown low rates of success in controlling disease progression. Few studies used high throughput genomic analysis in renal cell carcinoma for determination of prognosis. This study is focused on the identification of gene expression signatures in tissues of low-risk, high-risk and metastatic RCC clear cell type (RCC-CCT. MATERIALS AND METHODS: We analyzed the expression of approximately 55,000 distinct transcripts using the Whole Genome microarray platform hybridized with RNA extracted from 19 patients submitted to surgery to treat RCC-CCT with different clinical outcomes. They were divided into three groups (1 low risk, characterized by pT1, Fuhrman grade 1 or 2, no microvascular invasion RCC; (2 high risk, pT2-3, Fuhrman grade 3 or 4 with, necrosis and microvascular invasion present and (3 metastatic RCC-CCT. Normal renal tissue was used as control. RESULTS: After comparison of differentially expressed genes among low-risk, high-risk and metastatic groups, we identified a group of common genes characterizing metastatic disease. Among them Interleukin-8 and Heat shock protein 70 were over-expressed in metastasis and validated by real-time polymerase chain reaction. CONCLUSION: These findings can be used as a starting point to generate molecular markers of RCC-CCT as well as a target for the development of innovative therapies.

  11. Effect of mechanical optical clearing on near-infrared spectroscopy.

    Science.gov (United States)

    Idelson, Christopher R; Vogt, William C; King-Casas, Brooks; LaConte, Stephen M; Rylander, Christopher G

    2015-08-01

    Near-infrared Spectroscopy (NIRS) is a broadly utilized technology with many emerging applications including clinical diagnostics, sports medicine, and functional neuroimaging, to name a few. For functional brain imaging NIR light is delivered at multiple wavelengths through the scalp and skull to the brain to enable spatial oximetry measurements. Dynamic changes in brain oxygenation are highly correlated with neural stimulation, activation, and function. Unfortunately, NIRS is currently limited by its low spatial resolution, shallow penetration depth, and, perhaps most importantly, signal corruption due to light interactions with superficial non-target tissues such as scalp and skull. In response to these issues, we have combined the non-invasive and rapidly reversible method of mechanical tissue optical clearing (MOC) with a commercially available NIRS system. MOC utilizes a compressive loading force on tissue, causing the lateral displacement of blood and water, while simultaneously thinning the tissue. A MOC-NIRS Breath Hold Test displayed a ∼3.5-fold decrease in the time-averaged standard deviation between channels, consequentially promoting greater channel agreement. A Skin Pinch Test was implemented to negate brain and muscle activity from affecting the recorded signal. These results displayed a 2.5-3.0 fold increase in raw signal amplitude. Existing NIRS instrumentation has been further integrated within a custom helmet device to provide a uniform force distribution across the NIRS sensor array. These results showed a gradual decrease in time-averaged standard deviation among channels with an increase in applied pressure. Through these experiments, and the development of the MOC-NIRS helmet device, MOC appears to provide enhancement of NIRS technology beyond its current limitations.

  12. 77 FR 6335 - Protection of Cleared Swaps Customer Contracts and Collateral; Conforming Amendments to the...

    Science.gov (United States)

    2012-02-07

    ... merchants (``FCMs'') and derivatives clearing organizations (``DCOs'') regarding the treatment of cleared... the rules or bylaws of a derivatives clearing organization require that such transactions, along with the money, securities, and other property margining, guaranteeing or securing such transactions,...

  13. Clearing the Cosmic Fog - The Most Distant Galaxy Ever Measured

    Science.gov (United States)

    2010-10-01

    A European team of astronomers using ESO's Very Large Telescope (VLT) has measured the distance to the most remote galaxy so far. By carefully analysing the very faint glow of the galaxy they have found that they are seeing it when the Universe was only about 600 million years old (a redshift of 8.6). These are the first confirmed observations of a galaxy whose light is clearing the opaque hydrogen fog that filled the cosmos at this early time. The results were presented at an online press conference with the scientists on 19 October 2010, and will appear in the 21 October issue of the journal Nature. "Using the ESO Very Large Telescope we have confirmed that a galaxy spotted earlier using Hubble is the most remote object identified so far in the Universe" [1], says Matt Lehnert (Observatoire de Paris) who is lead author of the paper reporting the results. "The power of the VLT and its SINFONI spectrograph allows us to actually measure the distance to this very faint galaxy and we find that we are seeing it when the Universe was less than 600 million years old." Studying these first galaxies is extremely difficult. By the time that their initially brilliant light gets to Earth they appear very faint and small. Furthermore, this dim light falls mostly in the infrared part of the spectrum because its wavelength has been stretched by the expansion of the Universe - an effect known as redshift. To make matters worse, at this early time, less than a billion years after the Big Bang, the Universe was not fully transparent and much of it was filled with a hydrogen fog that absorbed the fierce ultraviolet light from young galaxies. The period when the fog was still being cleared by this ultraviolet light is known as the era of reionisation [2]. Despite these challenges the new Wide Field Camera 3 on the NASA/ESA Hubble Space Telescope discovered several robust candidate objects in 2009 [3] that were thought to be galaxies shining in the era of reionisation. Confirming the

  14. Madeleine Leininger: claroscuro trascultural Madeleine Leininger: Clear and dark transcultural

    Directory of Open Access Journals (Sweden)

    David Fornons Fontdevila

    2010-09-01

    Full Text Available A principios de la década de los años 60, Madeleine Leininger conceptualiza y funda la Enfermería transcultural, pero a pesar de la vigencia y reconocimiento que actualmente posee la enfermería transcultural, ésta no se escapa de un territorio claro-oscuro de contradicciones y dicciones. ¿Qué concepto de cultura utiliza Madeleine Leininger? ¿Qué consecuencias implica su transculturalidad? En el artículo se debate la particularidad conceptual utilizada por Leininger. Así mismo se propone cambiar terminológicamente y conceptualmente significados y significantes como la etnoenfermería y los conceptos de transculturalidad que a ella refieren. Para evitar los determinismos culturales se considera más correcto hablar de las identidades culturales, propias e individuales. La enfermería debe establecer un diálogo transcultural con las identidades culturales, con las medicinas y enfermerías transculturales. Un diálogo en igualdad, no sin por ello renunciar a la riqueza y eficiencia de la enfermería y de la medicina occidentales.At the beginning of the decade of the 60s, Madeleine Leininger conceptualizes and founds the nursing transcultural, but in spite of the current force and recognition that nowadays possesses the nursing transcultural, this does not escape of a clear - dark territory of contradictions and dictions. What concept of culture does Madeleine Leininger use? What consequences does it imply her transculturality? In the article the conceptual particularity used by Leininger is debated. Likewise it proposes to change the term and conceptual important and significant as the etno-infirmary and the concepts of transcultural that recount her. To avoid the cultural determinisms it is more correct to speak about the cultural, own and individual identities. The nursing must establish a dialog transcultural with the cultural identities, with the medicines and transcultural nursing. A dialog in equality, not without for it to resign

  15. Stony Brook's Graduate Courses in Clear, Vivid, Conversational Communication

    Science.gov (United States)

    Bass, E.

    2011-12-01

    Graduate students in the sciences at Stony Brook University are taking for-credit courses to learn to communicate more effectively about science with people outside their disciplines, including public officials, the press, students, potential funders and employers, colleagues in other fields, and the general public. Five Communicating Science courses are offered; two more will be added in January, 2012. The courses are offered by the School of Journalism and developed by the Center for Communicating Science (CCS). This interdisciplinary center was founded in 2009, with the participation of Alan Alda, the actor, writer, director and longtime advocate for science, who is a Visiting Professor at Stony Brook. At the core of the program are three 1-credit (14-hour) modules that rely on experiential learning, repeated practice and immediate, interactive feedback. In Distilling Your Message, students practice speaking clearly, vividly and conversationally about their work at different levels of complexity and formality to different audiences, using storytelling techniques where appropriate. In Writing for the Public, they extend these skills into writing. In Improvisation for Scientists, the most unconventional of the courses, students play improvisational theater games to help themselves connect more directly, personally and responsively with their audiences. In their first two semesters, the courses are expected to serve about 90 students, taking a total of about 180 credits. Most of the courses have filled quickly, mixing master's and doctoral students from more than a dozen fields, including marine and atmospheric sciences. Three to six credits of Communicating Science courses are required for students in two programs, an MA in Marine Conservation and Policy and an Advanced Certificate in Health Communications. The content and methods of the courses are based largely on lessons learned from evaluations of all-day workshops that CCS has conducted for more than 250

  16. 78 FR 62846 - Self-Regulatory Organizations; National Securities Clearing Corporation; Notice of Filing...

    Science.gov (United States)

    2013-10-22

    ... Supplemental Liquidity Deposits to Its Clearing Fund Designed To Increase Liquidity Resources To Meet Its Liquidity Needs October 15, 2013. On March 21, 2013, National Securities Clearing Corporation (``NSCC...'') to provide for supplemental liquidity deposits to its Clearing Fund (the ``NSCC Clearing Fund'')...

  17. Evaluation of Clear Sky Models for Satellite-Based Irradiance Estimates

    Energy Technology Data Exchange (ETDEWEB)

    Sengupta, M.; Gotseff, P.

    2013-12-01

    This report describes an intercomparison of three popular broadband clear sky solar irradiance model results with measured data, as well as satellite-based model clear sky results compared to measured clear sky data. The authors conclude that one of the popular clear sky models (the Bird clear sky model developed by Richard Bird and Roland Hulstrom) could serve as a more accurate replacement for current satellite-model clear sky estimations. Additionally, the analysis of the model results with respect to model input parameters indicates that rather than climatological, annual, or monthly mean input data, higher-time-resolution input parameters improve the general clear sky model performance.

  18. CLEAR Landscape Change Module: No Increased Restoration and Protection, UTM Zone 15N NAD83, Coastal Louisiana Ecosystem Assessment and Restoration (2007), [CLEAR_Output_NIA_012307_final

    Data.gov (United States)

    Louisiana Geographic Information Center — The Coastal Louisiana Ecosystem Assessment and Restoration (CLEAR) Framework is an integrated ecosystem forecasting system, designed to simulate ecological change...

  19. 21 CFR 878.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... (AIDS), chronic or active hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4...) For use in the diagnosis, monitoring, or screening of neoplastic diseases with the exception of immunohistochemical devices; (2) For use in screening or diagnosis of familial or acquired genetic...

  20. 21 CFR 874.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4) For assessing the risk of... immunoassay technology; or (c) The device is an in vitro device that is intended: (1) For use in the diagnosis... use in screening or diagnosis of familial or acquired genetic disorders, including inborn errors...

  1. 21 CFR 864.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... (AIDS), chronic or active hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4...) For use in the diagnosis, monitoring, or screening of neoplastic diseases with the exception of immunohistochemical devices; (2) For use in screening or diagnosis of familial or acquired genetic...

  2. 21 CFR 882.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4) For assessing the risk of... immunoassay technology; or (c) The device is an in vitro device that is intended: (1) For use in the diagnosis... use in screening or diagnosis of familial or acquired genetic disorders, including inborn errors...

  3. 21 CFR 890.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4) For assessing the risk of... immunoassay technology; or (c) The device is an in vitro device that is intended: (1) For use in the diagnosis... use in screening or diagnosis of familial or acquired genetic disorders, including inborn errors...

  4. 21 CFR 880.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... (AIDS), chronic or active hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4...) For use in the diagnosis, monitoring, or screening of neoplastic diseases with the exception of immunohistochemical devices; (2) For use in screening or diagnosis of familial or acquired genetic...

  5. 21 CFR 884.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... (AIDS), chronic or active hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4...) For use in the diagnosis, monitoring, or screening of neoplastic diseases with the exception of immunohistochemical devices; (2) For use in screening or diagnosis of familial or acquired genetic...

  6. 21 CFR 872.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4) For assessing the risk of... immunoassay technology; or (c) The device is an in vitro device that is intended: (1) For use in the diagnosis... use in screening or diagnosis of familial or acquired genetic disorders, including inborn errors...

  7. 21 CFR 892.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4) For assessing the risk of... immunoassay technology; or (c) The device is an in vitro device that is intended: (1) For use in the diagnosis... use in screening or diagnosis of familial or acquired genetic disorders, including inborn errors...

  8. 21 CFR 870.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4) For assessing the risk of... immunoassay technology; or (c) The device is an in vitro device that is intended: (1) For use in the diagnosis... use in screening or diagnosis of familial or acquired genetic disorders, including inborn errors...

  9. 21 CFR 866.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... (AIDS), chronic or active hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4...) For use in the diagnosis, monitoring, or screening of neoplastic diseases with the exception of immunohistochemical devices; (2) For use in screening or diagnosis of familial or acquired genetic...

  10. 21 CFR 886.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4) For assessing the risk of... immunoassay technology; or (c) The device is an in vitro device that is intended: (1) For use in the diagnosis... use in screening or diagnosis of familial or acquired genetic disorders, including inborn errors...

  11. 21 CFR 862.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... deficiency syndrome (AIDS), chronic or active hepatitis, tuberculosis, or myocardial infarction or to monitor... intended: (1) For use in the diagnosis, monitoring, or screening of neoplastic diseases with the exception of immunohistochemical devices; (2) For use in screening or diagnosis of familial or acquired...

  12. 21 CFR 888.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4) For assessing the risk of... immunoassay technology; or (c) The device is an in vitro device that is intended: (1) For use in the diagnosis... use in screening or diagnosis of familial or acquired genetic disorders, including inborn errors...

  13. 21 CFR 868.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4) For assessing the risk of... immunoassay technology; or (c) The device is an in vitro device that is intended: (1) For use in the diagnosis... use in screening or diagnosis of familial or acquired genetic disorders, including inborn errors...

  14. 21 CFR 876.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... (AIDS), chronic or active hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4...) For use in the diagnosis, monitoring, or screening of neoplastic diseases with the exception of immunohistochemical devices; (2) For use in screening or diagnosis of familial or acquired genetic...

  15. Pediatric evaluation of the ClearVoice™ speech enhancement algorithm in everyday life

    Directory of Open Access Journals (Sweden)

    Nathalie Noël-Petroff

    2013-12-01

    Full Text Available ClearVoice™ enables Advanced Bionics cochlear implant users to improve their speech understanding in difficult listening environments, without compromising performance in quiet situations. The aim of the study was to evaluate the benefits of ClearVoice in children. Children between six and fourteen years of age randomly tested two modalities of ClearVoice for one month each. The baseline program, HiRes 120™, and both ClearVoice programs were evaluated with a sentence test in quiet and noise. Parents and teachers completed a questionnaire related to everyday noisy situations. The switchover to ClearVoice was uneventful for both modalities. Adjustments to thresholds and comfort levels were required. Seven out of the nine children preferred a ClearVoice program. No impact of ClearVoice on performance in quiet was observed and both modalities of ClearVoice improved speech understanding in noise compared to the baseline program, significantly with ClearVoice high. Positive outcomes were obtained from the questionnaires and discussions with parents and children. This study showed that children benefited from using ClearVoice in their daily life. There was a clear trend towards improved speech understanding in noise with ClearVoice, without affecting performance in quiet; therefore ClearVoice can be used by children all day, without having to change programs.

  16. 78 FR 73553 - Prospective Grant of Exclusive License: Development of Cripto-1 Point of Care (POC) Tests and...

    Science.gov (United States)

    2013-12-06

    ... 510K cleared Point of Care (POC) tests and kits for the purpose of disease state recognition, detection..., pancreas, stomach, gallbladder, breast, lung, endometrium and cervix. Current methodologies of...

  17. 76 FR 16588 - Risk Management Requirements for Derivatives Clearing Organizations; Correction

    Science.gov (United States)

    2011-03-24

    ... From the Federal Register Online via the Government Publishing Office COMMODITY FUTURES TRADING COMMISSION 17 CFR Part 39 RIN 3038-AC98 Risk Management Requirements for Derivatives Clearing Organizations..., regarding Risk Management Requirements for Derivatives Clearing Organizations. FOR FURTHER...

  18. Clear cell variant of calcifying epithelial odontogenic tumor of maxilla: Report of a rare case.

    Science.gov (United States)

    Badrashetty, Dinesh; Rangaswamy, Shruthi; Belgode, Niranjan

    2013-09-01

    The calcifying epithelial odontogenic tumor (CEOT) is a rare benign tumor of the jaws. Pindborg's tumor having clear cells is extremely rare. Twelve central lesions have been reported of which only three cases have occurred in maxilla. Clear cell variant is a distinct entity, has more aggressive biological behavior and higher chances of recurrence. Hence it is important that presence of clear cells be included in histopathological diagnosis. Here we present a rare case of clear cell CEOT having aggressive behavior.

  19. 77 FR 67042 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of No Objection to...

    Science.gov (United States)

    2012-11-08

    ... implementing many of the new statutory core principles for CFTC-registered derivatives clearing organizations...-2011-18. \\8\\ See SR-OCC-2012-06. \\9\\ Derivatives Clearing Organization General Provisions and Core... the exercise, assignment or maturity of cleared contracts. For this reason, OCC will treat all...

  20. Talker Differences in Clear and Conversational Speech: Vowel Intelligibility for Older Adults with Hearing Loss

    Science.gov (United States)

    Ferguson, Sarah Hargus

    2012-01-01

    Purpose: To establish the range of talker variability for vowel intelligibility in clear versus conversational speech for older adults with hearing loss and to determine whether talkers who produced a clear speech benefit for young listeners with normal hearing also did so for older adults with hearing loss. Method: Clear and conversational vowels…

  1. Clear cell variant of intraosseous mucoepidermoid carcinoma: Report of a rare entity

    Directory of Open Access Journals (Sweden)

    Sujatha Varma

    2012-01-01

    Full Text Available Intraosseous mucoepidermoid carcinoma of jaw bones is a rare lesion. Abundance of clear cells in an intraosseous mucoepidermoid carcinoma may complicate its histopathologic diagnosis. It becomes extremely important to distinguish this lesion from other clear cell lesions of jaw region. Here, we report a case of clear cell variant of intraosseous mucoepidermoid carcinoma in the mandible.

  2. 45 CFR 5.67 - Exemption six: Clearly unwarranted invasion of personal privacy.

    Science.gov (United States)

    2010-10-01

    ...: Clearly unwarranted invasion of personal privacy. (a) Documents affected. We may withhold records about individuals if disclosure would constitute a clearly unwarranted invasion of their personal privacy. (b... 45 Public Welfare 1 2010-10-01 2010-10-01 false Exemption six: Clearly unwarranted invasion...

  3. 78 FR 61436 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing and Immediate...

    Science.gov (United States)

    2013-10-03

    ... to the Definition of Hedge Clearing Member September 27, 2013. Pursuant to Section 19(b)(1) of the... to the definition of Hedge Clearing Member. II. Clearing Agency's Statement of the Purpose of, and... the proposed rule change. The text of these statements may be examined at the places specified in...

  4. 77 FR 66900 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing of Proposed...

    Science.gov (United States)

    2012-11-07

    ... potential use of the clearing fund as a source of liquidity should it ever be the case that OCC is unable to... a failure of any bank or securities or commodities clearing organization to perform its obligations... provide a source of liquidity in the event of a default by a clearing member or one of OCC's...

  5. Clear-cell variant of calcifying epithelial odontogenic tumor (Pindborg tumor) in the mandible

    Institute of Scientific and Technical Information of China (English)

    Ching-Yi Chen; Chung-Wei Wu; Wen-Chen Wang; Li-Min Lin; Yuk-Kwan Chen

    2013-01-01

    We present an uncommon case (female patient aged 59 years) of the clear-cell variant of calcifying epithelial odontogenic tumor (CEOT) (also known as Pindborg tumor) in the mandible. The clinical characteristics and probable origins of the clear tumor cells of previously reported cases of clear-cell variant of intraosseous CEOT are also summarized and discussed.

  6. 77 FR 75466 - Self-Regulatory Organizations; ICE Clear Europe Limited; Notice of Designation of a Longer Period...

    Science.gov (United States)

    2012-12-20

    ... ICE Clear Europe to clear Western European Sovereign credit default swaps on the following sovereign... for Western European Sovereign credit default swaps, and because no registered clearing agency currently provides clearing services for Western European Sovereign credit default swaps, the......

  7. Carcinomas of ovary and lung with clear cell features: can immunohistochemistry help in differential diagnosis?

    Science.gov (United States)

    Howell, Nicole R; Zheng, Wenxin; Cheng, Liang; Tornos, Carmen; Kane, Philip; Pearl, Michael; Chalas, Eva; Liang, Sharon X

    2007-04-01

    Metastatic lung carcinomas with clear cell morphology can be confused with primary ovarian clear cell carcinomas. We performed immunohistochemical stains in 14 cases of non-small cell lung carcinomas with clear cell features and 14 cases of ovarian clear cell carcinomas using a panel of markers, including thyroid transcription factor 1 (TTF-1), carcinoembryonic antigen (CEA), Wilms tumor gene 1, octamer-binding transcription factor 4 (OCT-4), cancer antigen 125 (CA-125), estrogen receptor, and progesterone receptor. Among non-small cell lung carcinomas with clear cell features, 87.5% of adenocarcinomas (or 50% overall frequency in lung carcinomas) were positive for TTF-1, whereas none of the ovarian clear cell carcinomas were positive (P = 0.002). All 14 ovarian clear cell carcinomas stained for CA-125 as compared with 1 non-small cell lung carcinoma (P < 0.001). On the other hand, 85% of non-small cell lung carcinomas stained for CEA, whereas none of the ovarian clear cell carcinomas did (P < 0.001). Interestingly, 4 ovarian clear cell carcinomas (28%) showed positive staining for the germ cell marker OCT-4. Either lung or ovarian carcinomas stained for Wilms tumor gene 1, estrogen receptor, or progesterone receptor very infrequently; and the difference between the 2 groups was not statistically significant. Our results suggest that an immunohistochemical panel consisting of TTF-1, CEA, CA-125, and OCT-4 is helpful in distinguishing most pulmonary and ovarian carcinomas with clear cell features.

  8. Detection and clearing of trapped ions in the high current Cornell photoinjector

    Science.gov (United States)

    Full, S.; Bartnik, A.; Bazarov, I. V.; Dobbins, J.; Dunham, B.; Hoffstaetter, G. H.

    2016-03-01

    We have recently performed experiments to test the effectiveness of three ion-clearing strategies in the Cornell high intensity photoinjector: DC clearing electrodes, bunch gaps, and beam shaking. The photoinjector reaches a new regime of linac beam parameters where high continuous wave beam currents lead to ion trapping. Therefore ion mitigation strategies must be evaluated for this machine and other similar future high current linacs. We have developed several techniques to directly measure the residual trapped ions. Our two primary indicators of successful clearing are the amount of ion current removed by a DC clearing electrode, and the absence of bremsstrahlung radiation generated by beam-ion interactions. Measurements were taken for an electron beam with an energy of 5 MeV and continuous wave beam currents in the range of 1-20 mA. Several theoretical models have been developed to explain our data. Using them, we are able to estimate the clearing electrode voltage required for maximum ion clearing, the creation and clearing rates of the ions while employing bunch gaps, and the sinusoidal shaking frequency necessary for clearing via beam shaking. In all cases, we achieve a maximum ion clearing of at least 70% or higher, and in some cases our data is consistent with full ion clearing.

  9. Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement: molecular analysis of 94 salivary gland carcinomas with prominent clear cell component.

    Science.gov (United States)

    Skálová, Alena; Weinreb, Ilan; Hyrcza, Martin; Simpson, Roderick H W; Laco, Jan; Agaimy, Abbas; Vazmitel, Marina; Majewska, Hanna; Vanecek, Tomas; Talarčik, Peter; Manajlovic, Spomenka; Losito, Simona N; Šteiner, Petr; Klimkova, Adela; Michal, Michal

    2015-03-01

    This study examines the presence of the EWSR1 rearrangement in a variety of clear cell salivary gland carcinomas with myoepithelial differentiation. A total of 94 salivary gland carcinomas with a prominent clear cell component included 51 cases of clear cell myoepithelial carcinomas de novo (CCMC), 21 cases of CCMCs ex pleomorphic adenoma (CCMCexPA), 11 cases of epithelial-myoepithelial carcinoma (EMC), 6 cases of EMC with solid clear cell overgrowth, and 5 cases of hyalinizing clear cell carcinoma of minor salivary glands. In addition, 10 cases of myoepithelial carcinomas devoid of clear cell change and 12 cases of benign myoepithelioma were included as well. All the tumors in this spectrum were reviewed, reclassified, and tested by fluorescence in situ hybridization (FISH) for the EWSR1 rearrangement using the Probe Vysis EWSR1 Break Apart FISH Probe Kit. The EWSR1 rearrangement was detected in 20 of 51 (39%) cases of CCMC, in 5 of 21 (24%) cases of CCMCexPA, in 1 of 11 (9%) cases of EMC, and in 4 of 5 (80%) cases of hyalinizing clear cell carcinoma. The 25 EWSR1-rearranged CCMCs and CCMCexPAs shared similar histomorphology. They were arranged in nodules composed of compact nests of large polyhedral cells with abundant clear cytoplasm. Necrosis, areas of squamous metaplasia, and hyalinization were frequent features. Immunohistochemically, the tumors expressed p63 (96%), cytokeratin CK14 (96%), and S100 protein (88%). MIB1 index varied from 10% to 100%, with most cases in the 20% to 40% range. Clinical follow-up information was available in 21 cases (84%) and ranged from 3 months to 15 years (mean 5.2 y); 4 patients were lost to follow-up. Ten patients are alive with no evidence of recurrent or metastatic disease in the follow-up period from 3 months to 15 years (mean 5 y), 3 patients are alive with recurrent and metastatic disease, and 8 died of disseminated cancer 9 months to 16 years after diagnosis (mean 6 y). Lymph node metastasis appeared in 5 patients

  10. Estimation of direct illuminance on a horizontal surface for clear and intermediate skies

    Energy Technology Data Exchange (ETDEWEB)

    Robledo, L. [Universidad Politecnica de Madrid (Spain). Dpto. Sistemas Intelligentes Aplicados; Soler, A. [E.T.S. Arquitectura, Madrid (Spain). Dpto. de Fisica e Instalaciones Aplicados; Universidad Politecnico de Madrid (Spain). Facultad de Ciencias Ambientales

    2000-02-01

    In the present work two simple models have been obtained which may be used to estimate mean hourly direct illuminance for clear skies as a function of solar elevation. Also a simple model has been developed valid for all sky conditions When direct illuminance is available, that is clear and intermediate skies, using solar elevation and brightness index as input parameters. The sky conditions are defined by the clearness index and the brightness index, both calculated from solar irradiances. (author)

  11. Clear cell variant of calcifying epithelial odontogenic tumor of maxilla: Report of a rare case

    Directory of Open Access Journals (Sweden)

    Dinesh Badrashetty

    2013-01-01

    Full Text Available The calcifying epithelial odontogenic tumor (CEOT is a rare benign tumor of the jaws. Pindborg′s tumor having clear cells is extremely rare. Twelve central lesions have been reported of which only three cases have occurred in maxilla. Clear cell variant is a distinct entity, has more aggressive biological behavior and higher chances of recurrence. Hence it is important that presence of clear cells be included in histopathological diagnosis. Here we present a rare case of clear cell CEOT having aggressive behavior.

  12. Tongue-Palate Contact Pressure, Oral Air Pressure, and Acoustics of Clear Speech

    Science.gov (United States)

    Searl, Jeff; Evitts, Paul M.

    2013-01-01

    Purpose: The authors compared articulatory contact pressure (ACP), oral air pressure (Po), and speech acoustics for conversational versus clear speech. They also assessed the relationship of these measures to listener perception. Method: Twelve adults with normal speech produced monosyllables in a phrase using conversational and clear speech.…

  13. Clear-Cell Adenocarcinoma of Vesical Origin: A Case Study of Metastatic Disease Treated with Chemotherapy

    Directory of Open Access Journals (Sweden)

    Carolina Pena Álvarez

    2010-01-01

    Full Text Available Vesical clear cell adenocarcinoma is an uncommon tumour. The description of nearly all published cases focuses on histological issues, providing few clinical particulars and limited followup. The treatment choice is resection. No publications have been found regarding systemic treatments for advanced disease. We present a case of metastatic clear cell adenocarcinoma of the bladder treated with chemotherapy.

  14. 75 FR 17805 - Self-Regulatory Organizations; the Options Clearing Corporation; Notice of Filing of Proposed...

    Science.gov (United States)

    2010-04-07

    ... Change Relating to Cash-Settled Foreign Currency Options With One-Cent Exercise Prices April 1, 2010... clear that cash-settled foreign currency options traded on national securities exchanges will be treated... XXII of its By-Laws to make clear that cash- settled foreign currency options traded on...

  15. 75 FR 44833 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing and Immediate...

    Science.gov (United States)

    2010-07-29

    ... would credit foreign currency toward clearing fund and margin requirements. OCC does not presently accept foreign currency either as clearing fund contributions or margin deposits. However, because... securities. When determining the U.S. dollar value of such foreign currency, OCC would conduct its...

  16. 78 FR 62893 - Self-Regulatory Organizations; National Securities Clearing Corporation; Notice of Filing...

    Science.gov (United States)

    2013-10-22

    ... Supplemental Liquidity Deposits to Its Clearing Fund Designed To Increase Liquidity Resources To Meet Its Liquidity Needs October 15, 2013. On March 21, 2013, National Securities Clearing Corporation (``NSCC... proposal by NSCC to amend its Rules & Procedures (the ``NSCC Rules'') to provide for supplemental...

  17. 78 FR 32292 - Self-Regulatory Organizations; National Securities Clearing Corporation; Notice of Filing...

    Science.gov (United States)

    2013-05-29

    ... Modified by Amendment No. 1, To Institute Supplemental Liquidity Deposits to Its Clearing Fund Designed To Increase Liquidity Resources To Meet Its Liquidity Needs May 22, 2013. On March 21, 2013, National... members to provide supplemental liquidity deposits to NSCC's Clearing Fund, in order to increase...

  18. 78 FR 60347 - Self-Regulatory Organizations; National Securities Clearing Corporation; Notice of Designation of...

    Science.gov (United States)

    2013-10-01

    ... Proposed Rule Change, as Modified by Amendment Nos. 1 and 2, To Institute Supplemental Liquidity Deposits to Its Clearing Funding Designed To Increase Liquidity Resources To Meet Its Liquidity Needs... supplemental liquidity deposits to its Clearing Fund in order to increase liquidity resources to meet...

  19. 76 FR 12645 - Ownership Limitations and Governance Requirements for Security-Based Swap Clearing Agencies...

    Science.gov (United States)

    2011-03-08

    ... COMMISSION 17 CFR Part 242 RIN 3235-AK74 Ownership Limitations and Governance Requirements for Security... FURTHER INFORMATION CONTACT: Proposals relating to security-based swap clearing agencies: Catherine Moore... in and the governance of security-based swap clearing agencies, SB SEFs and SBS...

  20. 77 FR 24999 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing and Order...

    Science.gov (United States)

    2012-04-26

    .... Central Time on the first business day following the day on which OCC notifies the clearing member of such... of the Rules), including a violation of Rule 215, from a clearing member's bank account, provided... on a fine schedule that has been adopted by operating subsidiaries of the Depository Trust &...

  1. Characterizing the Effects of a Vertical Time Threshold for a Class of Well-Clear Definitions

    Science.gov (United States)

    Upchurch, Jason M.; Munoz, Cesar A.; Narkawicz, Anthony J.; Consiglio, Maria C.; Chamberlain James P.

    2015-01-01

    A fundamental requirement for the integration of unmanned aircraft into civil airspace is the capability of aircraft to remain well clear of each other and avoid collisions. This requirement has led to a broad recognition of the need for an unambiguous, formal definition of well clear. It is further recognized that any such definition must be interoperable with existing airborne collision avoidance systems (ACAS). A particular class of well-clear definitions uses logic checks of independent distance thresholds as well as independent time thresholds in the vertical and horizontal dimensions to determine if a well-clear violation is predicted to occur within a given time interval. Existing ACAS systems also use independent distance thresholds, however a common time threshold is used for the vertical and horizontal logic checks. The main contribution of this paper is the characterization of the effects of the decoupled vertical time threshold on a well-clear definition in terms of (1) time to well-clear violation, and (2) interoperability with existing ACAS. The paper provides governing equations for both metrics and includes simulation results to illustrate the relationships. In this paper, interoperability implies that the time of well-clear violation is strictly less than the time a resolution advisory is issued by ACAS. The encounter geometries under consideration in this paper are initially well clear and consist of constant-velocity trajectories resulting in near-mid-air collisions.

  2. 33 CFR 263.24 - Authority for snagging and clearing for flood control (Section 208).

    Science.gov (United States)

    2010-07-01

    ... clearing for flood control (Section 208). 263.24 Section 263.24 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE CONTINUING AUTHORITIES PROGRAMS Flood Control Policy § 263.24 Authority for snagging and clearing for flood control (Section 208). (a)...

  3. 77 FR 67036 - Self-Regulatory Organizations; The Options Clearing Corporation; Order Approving Proposed Rule...

    Science.gov (United States)

    2012-11-08

    ... October 18, 2011, the CFTC issued final regulations implementing many of the new statutory core principles... Clearing Organization General Provisions and Core Principles, 76 FR 69334, 69439 (November 8, 2011). OCC's... settlement obligations arising from the exercise, assignment or maturity of cleared contracts. For...

  4. 76 FR 51087 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing of Proposed...

    Science.gov (United States)

    2011-08-17

    ... exposure in extreme but plausible market conditions.'' The publication further advises clearing... during extreme market conditions. Article VIII, Section 6 of OCC's By-Laws, which obligates clearing... the adaptation of the methodology underlying the formula change made to incorporate the effects...

  5. Apoptotic Cells Are Cleared by Directional Migration and elmo1-Dependent Macrophage Engulfment

    NARCIS (Netherlands)

    van Ham, Tjakko J.; Kokel, David; Peterson, Randall T.

    2012-01-01

    Apoptotic cell death is essential for development and tissue homeostasis [1, 2]. Failure to clear apoptotic cells can ultimately cause inflammation and autoimmunity [3, 4]. Apoptosis has primarily been studied by staining of fixed tissue sections, and a clear understanding of the behavior of apoptot

  6. Clear cell adenocarcinoma of the colon: A case report and review of literature

    Institute of Scientific and Technical Information of China (English)

    Koichi Soga; Ken-Ichi Mukaisho; Takanori Hattori; Hideyuki Konishi; Natsuko Tatsumi; Chika Konishi; Keimei Nakano; Naold Wakabayashi; Shoji Mitsufuji; Keisho Kataoka; Takeshi Okanoue

    2008-01-01

    A primary clear cell adenocarcinoma of the colon is arare oncologic entity.We herein report a case of such atumor of the sigmoid colon in a 71-year-old woman whowas successfully treated by an endoscopic polypecLomy in our hospital.We also reviewed the published reports regarding cases of primary clear cell tumors in the colon.

  7. 75 FR 81264 - Critical Path Transmission, LLC; Clear Power, LLC; v. California Independent System Operator, Inc...

    Science.gov (United States)

    2010-12-27

    ... Energy Regulatory Commission Critical Path Transmission, LLC; Clear Power, LLC; v. California Independent... (Commission), 18 CFR 385.206 (2010) and sections 206 and 306 of the Federal Power Act, 16 U.S.C. 824e and 825e (2006), Critical Path Transmission, LLC and Clear Power LLC (Complainants) filed a complaint...

  8. 14 CFR 417.411 - Safety clear zones for hazardous operations.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Safety clear zones for hazardous operations. 417.411 Section 417.411 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION... for hazardous operations. (a) A launch operator must define a safety clear zone that confines...

  9. A Family of Well-Clear Boundary Models for the Integration of UAS in the NAS

    Science.gov (United States)

    Munoz, Cesar A.; Narkawicz, Anthony; Chamberlain, James; Consiglio, Maria; Upchurch, Jason

    2014-01-01

    The FAA-sponsored Sense and Avoid Workshop for Unmanned Aircraft Systems (UAS) defines the concept of sense and avoid for remote pilots as "the capability of a UAS to remain well clear from and avoid collisions with other airborne traffic." Hence, a rigorous definition of well clear is fundamental to any separation assurance concept for the integration of UAS into civil airspace. This paper presents a family of well-clear boundary models based on the TCAS II Resolution Advisory logic. For these models, algorithms that predict well-clear violations along aircraft current trajectories are provided. These algorithms are analogous to conflict detection algorithms but instead of predicting loss of separation, they predict whether well-clear violations will occur during a given lookahead time interval. Analytical techniques are used to study the properties and relationships satisfied by the models.

  10. Clear Cell Sarcoma of Gluteal Region Malignant Melanoma of Soft Parts

    Directory of Open Access Journals (Sweden)

    Haren V. Oza

    2013-04-01

    Full Text Available Clear cell sarcoma (CCS is described as variant of sarcoma characterized by prominent clear cells showing features similar to malignant melanoma of soft parts. This neoplasm was first described by Dr. Franz m. Enzinger. Primary CCS usually arises in deeper soft tissues, in association with fascia, tendons, or aponeuroses. Clear cell sarcoma (CCS is a rare malignant tumor with a propensity for slow progressive invasion. It is a tumor derived from Melanoblast like cell. They occur most commonly in the extremities, with a predilection for young females. Clear cell sarcoma of tendons and aponeuroses (malignant melanoma of soft parts and conventional malignant melanoma may demonstrate significant morphologic overlap at the light microscopic and ultra structural level. The tumor is very rare and can pose clinical challenges in early diagnosis. This case report demonstrates an unusual site of occurrence for clear cell sarcoma. [Natl J Med Res 2013; 3(2.000: 193-195

  11. Preparation of Samples for Leaf Architecture Studies, A Method for Mounting Cleared Leaves

    Directory of Open Access Journals (Sweden)

    Alejandra Vasco

    2014-09-01

    Full Text Available Premise of the study: Several recent waves of interest in leaf architecture have shown an expanding range of approaches and applications across a number of disciplines. Despite this increased interest, examination of existing archives of cleared and mounted leaves shows that current methods for mounting, in particular, yield unsatisfactory results and deterioration of samples over relatively short periods. Although techniques for clearing and staining leaves are numerous, published techniques for mounting leaves are scarce. Methods and Results: Here we present a complete protocol and recommendations for clearing, staining, and imaging leaves, and, most importantly, a method to permanently mount cleared leaves. Conclusions: The mounting protocol is faster than other methods, inexpensive, and straightforward; moreover, it yields clear and permanent samples that can easily be imaged, scanned, and stored. Specimens mounted with this method preserve well, with leaves that were mounted more than 35 years ago showing no signs of bubbling or discoloration.

  12. Identification of novel therapeutic targets in microdissected clear cell ovarian cancers.

    Directory of Open Access Journals (Sweden)

    Michael P Stany

    Full Text Available Clear cell ovarian cancer is an epithelial ovarian cancer histotype that is less responsive to chemotherapy and carries poorer prognosis than serous and endometrioid histotypes. Despite this, patients with these tumors are treated in a similar fashion as all other ovarian cancers. Previous genomic analysis has suggested that clear cell cancers represent a unique tumor subtype. Here we generated the first whole genomic expression profiling using epithelial component of clear cell ovarian cancers and normal ovarian surface specimens isolated by laser capture microdissection. All the arrays were analyzed using BRB ArrayTools and PathwayStudio software to identify the signaling pathways. Identified pathways validated using serous, clear cell cancer cell lines and RNAi technology. In vivo validations carried out using an orthotopic mouse model and liposomal encapsulated siRNA. Patient-derived clear cell and serous ovarian tumors were grafted under the renal capsule of NOD-SCID mice to evaluate the therapeutic potential of the identified pathway. We identified major activated pathways in clear cells involving in hypoxic cell growth, angiogenesis, and glucose metabolism not seen in other histotypes. Knockdown of key genes in these pathways sensitized clear cell ovarian cancer cell lines to hypoxia/glucose deprivation. In vivo experiments using patient derived tumors demonstrate that clear cell tumors are exquisitely sensitive to antiangiogenesis therapy (i.e. sunitinib compared with serous tumors. We generated a histotype specific, gene signature associated with clear cell ovarian cancer which identifies important activated pathways critical for their clinicopathologic characteristics. These results provide a rational basis for a radically different treatment for ovarian clear cell patients.

  13. 77 FR 13678 - Self-Regulatory Organizations; ICE Clear Credit LLC; Notice of Filing of Proposed Rule To Provide...

    Science.gov (United States)

    2012-03-07

    ... in a Clearing Participant's Customer Account Origin May Be Satisfied by a Clearing Participant... cleared in a clearing participant's customer account origin may be satisfied by the clearing participant... participants to satisfy the initial margin-related liquidity requirements for client-related positions...

  14. A study of metalized electrode self-clearing in electroactive polymer (EAP) based actuators

    Science.gov (United States)

    Ahmed, Saad; Ounaies, Zoubeida

    2016-04-01

    Electroactive polymer (EAP) based technologies have shown promise in areas such as artificial muscles, actuator, aerospace, medical and soft robotics. Still challenges remain such as low induced forces and defects-driven electrical breakdown, which impede the practical implementation of this technology. Multilayered or stacked configuration can address the low induced force issue whereas self-clearing can be a technique to improve breakdown limit of EAP based actuators. Self-clearing refers to the partial local breakdown of dielectric medium due to the presence of impurities, which in turn results in the evaporation of some of the metalized electrode. After this evaporation, the impurity is cleared and any current path would be safely cut off, which means the actuator continues to perform. It is a widely studied concept in the capacitor community, while it has not been studied much for EAP technologies. In this paper we report a systematic approach to precondition a silver-metalized electroactive polymer (EAP), more specifically P(VDF-TrFE-CTFE) terpolymer, using self-clearing concept. First, we show improvement in the dielectric breakdown strength of EAP based unimorph actuators after pre-clearing the impurities using low electric field (lower than dielectric breakdown of the terpolymer). Inspired by this improvement, we used Weibull statistics to systematically estimate the self-clearing/ preconditioning field needed to clear the defects. Then electrical breakdown experiments are conducted with and without preconditioning the samples to investigate its effect on the breakdown strength of the sample.

  15. Children's Perception of Conversational and Clear American-English Vowels in Noise

    Science.gov (United States)

    Leone, Dorothy

    A handful of studies have examined children's perception of clear speech in the presence of background noise. Although accurate vowel perception is important for listeners' comprehension, no study has focused on whether vowels uttered in clear speech aid intelligibility for children listeners. In the present study, American-English (AE) speaking children repeated the AE vowels /epsilon, ae, alpha, lambda in the nonsense word /g[schwa]bVp[schwa]/ in phrases produced in conversational and clear speech by two female AE-speaking adults. The recordings of the adults' speech were presented at a signal-to-noise ratio (SNR) of -6 dB to 15 AE-speaking children (ages 5.0-8.5) in an examination of whether the accuracy of AE school-age children's vowel identification in noise is more accurate when utterances are produced in clear speech than in conversational speech. Effects of the particular vowel uttered and talker effects were also examined. Clear speech vowels were repeated significantly more accurately (87%) than conversational speech vowels (59%), suggesting that clear speech aids children's vowel identification. Results varied as a function of the talker and particular vowel uttered. Child listeners repeated one talker's vowels more accurately than the other's and front vowels more accurately than central and back vowels. The findings support the use of clear speech for enhancing adult-to-child communication in AE, particularly in noisy environments.

  16. Clear cell adenocarcinoma of a female urethra: A case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Amel Trabelsi

    2009-01-01

    Full Text Available Context : Clear cell adenocarcinoma of the urethra is an extremely rare tumour. Its histogenetic derivation remains controversial. Case report : We report a new case of clear cell adenocarcinoma of the proximal urethra in a 56-year-old woman who presented with grossly hematuria. Urethral cystoscopy revealed a tumour protruding from the posterior urethral wall at the bladder neck. Treatment consisted of urethrocystectomy with pelvic lymph node dissection. Histologically, the neoplasm consisted of clear cell adenocarcinoma of the urethra. Conclusion : It appears that female urethral adenocarcinoma has more than one tissue of origin.

  17. Improving HelioClim-3 estimates of surface solar using the McClear clear-sky model and recent advances on atmosphere composition

    Directory of Open Access Journals (Sweden)

    Z. Qu

    2014-07-01

    Full Text Available The HelioClim-3 database (HC3v3 provides records of surface solar irradiation every 15 min estimated by processing images from the geostationary meteorological Meteosat satellites using climatological data sets of atmospheric Linke turbidity factor. This technical note proposes a method to improve a posteriori HC3v3 by combining it with data records of the irradiation under clear sky from the new clear-sky model McClear whose inputs are the advanced global aerosol properties forecasts and physically consistent total column content in water vapour and ozone produced by the MACC projects. The method is validated by comparison with a series of ground measurements for 15 min and 1 h for 6 stations and for daily irradiation for 23 stations. The correlation coefficient is large, greater than respectively 0.92, 0.94, and 0.97, for 15 min, 1 h and daily irradiation. The bias ranges between −4 and 4% of the mean observed irradiation for most sites. The relative root mean square difference (RMSD varies between 14 and 38% for 15 min, 12 and 33% for 1 h irradiation, and 6 and 20% for daily irradiation. As a rule of thumb, the farther from the nadir of the Meteosat satellite located at latitude 0° and longitude 0°, and the greater the occurrence of fragmented cloud cover, the greater the relative RMSD. The method improves HC3v3 in most cases and no degradation in the others. A systematic correction of HC3v3 with McClear is recommended.

  18. A Case of Hyalinizing Clear Cell Carcinoma, So-Called Clear Cell Carcinoma, Not Otherwise Specified, of the Minor Salivary Glands of the Buccal Mucosa

    Directory of Open Access Journals (Sweden)

    Takahiro Yamanishi

    2015-01-01

    Full Text Available Hyalinizing clear cell carcinoma (HCCC, so-called clear cell carcinoma, not otherwise specified (CCC (NOS, of the salivary glands is a rare and low-grade malignant tumor. We report a case of HCCC so-called CCC (NOS (referred to as HCCC of the minor salivary gland of the buccal mucosa. A 52-year-old woman had presented with a gradually growing and indolent mass in the right buccal mucosa for about two years. The first biopsy histopathologically suggested the possibility of malignancy derived from the minor salivary glands. A month later, she visited our hospital. The tumor measured approximately 1.5 cm in diameter and was elastic hard, smooth, and well movable. Image examinations demonstrated internal homogeneity of the lesion, which had a smooth margin, in the right buccal mucosa. Complete tumor resection followed by covering with a polyglycolic acid sheet and fibrin glue spray was performed without surgical flap reconstruction. Histopathological findings revealed proliferating tumor cells with clear cytoplasm surrounded by hyalinizing stroma in the submucosal minor salivary glands. Immunohistochemical stains revealed these tumor cells to be positive for epithelial cell markers but negative for myoepithelial ones. These findings confirmed the diagnosis of HCCC. Good wound healing and no evidence of local recurrence and metastasis have been shown since surgery.

  19. 76 FR 33817 - Protection of Cleared Swaps Customer Contracts and Collateral; Conforming Amendments to the...

    Science.gov (United States)

    2011-06-09

    ... commission merchants (``FCMs'') and derivatives clearing organizations (``DCOs'') regarding the treatment of.... Permitted Investments b. Permitted Withdrawals c. Deposits of Own Money, Securities, or Other Property d.... Question f. Segregated Account; Daily Computation and Record C. Proposed Regulation...

  20. SR-CATS: A Short-Range Clear Air Turbulence Sensor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Clear air turbulence (CAT), often referred to as "air pockets," is attributed to Kelvin-Helmholtz instabilities at altitudes generally above 18,000ft, often in the...

  1. 75 FR 65538 - Self-Regulatory Organizations; the Options Clearing Corporation; Notice of Filing and Immediate...

    Science.gov (United States)

    2010-10-25

    ... and reconciliation problems for the firms involved. At the request of the Roundtable, OCC has... amounts against a clearing member's bank account is not honored, OCC will have no obligation to effect...

  2. Clear Cell Adenocarcinoma of the Renal Pelvis in a Male Patient

    Directory of Open Access Journals (Sweden)

    Sarawut Kongkarnka

    2013-01-01

    Full Text Available Carcinoma of the renal pelvis is an uncommon renal neoplasm. Clear cell adenocarcinoma in the urinary tract is rare and has a histomorphology resembling that of the female genital tract. We herein present a case of clear cell adenocarcinoma of the renal pelvis, which is the first example in a male patient to our knowledge. A 54-year-old man presented with right flank pain. The tumor was associated with renal stones and hydronephrosis and invaded into the peripelvic fat tissue with regional lymph node metastasis. The patient died of metastatic disease six months postoperatively. Histologically, the tumor showed complex papillary architecture lined with clear and hobnail cells. Clear cell adenocarcinoma of the renal pelvis may pose a diagnostic challenge on histological grounds, particularly in the distinction from renal cell carcinoma. The immunohistochemical stains could help confirm the diagnosis. Due to its rarity, an effective treatment regimen remains to be determined.

  3. 78 FR 31616 - Self-Regulatory Organizations; National Securities Clearing Corporation; Notice of Extension of...

    Science.gov (United States)

    2013-05-24

    ... Advance Notice, as Modified by Amendment No. 1, To Institute Supplemental Liquidity Deposits to Its Clearing Fund Designed to Increase Liquidity Resources To Meet Its Liquidity Needs May 20, 2013. On...

  4. Renal cell carcinoma: evolving approaches to advanced non-clear cell carcinoma

    Directory of Open Access Journals (Sweden)

    Ronald M. Bukowski

    2011-12-01

    Full Text Available The treatment of metastatic renal cell carcinoma (RCC has changed dramatically with the introduction of targeted therapies including sunitinib, sorafenib, and temsirolimus. Because patients with conventional clear cell histology account for 75- 80% of all patients with RCC, there has been little accumulated evidence on the treatment of patients with non-clear cell histologies. Most clinical trials have excluded them from enrolment, except for randomized studies investigating temsirolimus. Many retrospective studies on the use of all three of these targeted therapies in patients with non-clear cell histology have demonstrated response rates ranging from 3.7%–16%. Although response rates may not be as high compared to patients with clear cell histologies, targeted therapy does provide a clinically meaningful response.

  5. Clear Lake National Wildlife Refuge : Klamath Basin National Wildlife Refuges : Annual Narrative Report : Calendar Year 1981

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Clear Lake National Wildlife Refuge outlines Refuge accomplishments during the 1981 calendar year. The report begins with a summary...

  6. Intelligibility and acoustic characteristics of clear and conversational speech in telugu (a South Indian dravidian language).

    Science.gov (United States)

    Durisala, Naresh; Prakash, S G R; Nambi, Arivudai; Batra, Ridhima

    2011-04-01

    The overall goal of this study is to examine the intelligibility differences of clear and conversational speech and also to objectively analyze the acoustic properties contributing to these differences. Seventeen post-lingual stable sensory-neural hearing impaired listeners with an age range of 17-40 years were recruited for the study. Forty Telugu sentences spoken by a female Telugu speaker in both clear and conversational speech styles were used as stimuli for the subjects. Results revealed that mean scores of clear speech were higher (mean = 84.5) when compared to conversational speech (mean = 61.4) with an advantage of 23.1% points. Acoustic properties revealed greater fundamental frequency (f0) and intensity, longer duration, higher consonant-vowel ratio (CVR) and greater temporal energy in clear speech.

  7. Clear-cell chondrosarcoma of the maxilla Report of a case

    NARCIS (Netherlands)

    Slootweg, P.J.

    1980-01-01

    Clear-cell chondrosarcoma is a variant of chondrosarcoma which is characterized by a typical histomorphology and a very slow rate of growth. A case is presented in which the tumor was located in the maxilla.

  8. NESDIS-Unique CrIS-ATMS Product System (NUCAPS) Cloud-Cleared Radiances

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset consists of Cloud-Cleared Radiances (CCRs) from the NOAA-Unique CrIS-ATMS Processing System (NUCAPS). NUCAPS was developed by the NOAA/NESDIS Center for...

  9. On the Relation between Solar Activity and Clear-Sky Terrestrial Irradiance

    CERN Document Server

    Feulner, Georg

    2012-01-01

    The Mauna Loa Observatory record of direct-beam solar irradiance measurements for the years 1958-2010 is analysed to investigate the variation of clear-sky terrestrial insolation with solar activity over more than four solar cycles. The raw irradiance data exhibit a marked seasonal cycle, extended periods of lower irradiance due to emissions of volcanic aerosols, and a long-term decrease in atmospheric transmission independent of solar activity. After correcting for these effects, it is found that clear-sky terrestrial irradiance typically varies by about 0.2 +/- 0.1% over the course of the solar cycle, a change of the same order of magnitude as the variations of the total solar irradiance above the atmosphere. An investigation of changes in the clear-sky atmospheric transmission fails to find a significant trend with sunspot number. Hence there is no evidence for a yet unknown effect amplifying variations of clear-sky irradiance with solar activity.

  10. Chondroblastoma and clear cell chondrosarcoma: radiological and MRI characteristics with histopathological correlation

    Energy Technology Data Exchange (ETDEWEB)

    Kaim, Achim H.; Huegli, Rolf [Institute of Diagnostic Radiology, University Hospital Basle (Switzerland); Bonel, Harald M. [Institute of Clinical Radiology, University Hospital, Munich-Grosshadern (Germany); Jundt, Gernot [Institute of Pathology, University Hospital Basle (Switzerland)

    2002-02-01

    Objective: To analyze and compare the radiological and magnetic resonance imaging (MRI) appearances of chondroblastoma and clear cell chondrosarcoma with histopathological correlation. Design and patients: Twelve patients with histologically proven chondroblastoma and of another four patients with clear cell chondrosarcoma were investigated by radiographs and MRI (T1-, T2-weighted sequences, intravenous gadolinium application). Additionally, the clinical and radiologic data of seven cases of clear cell chondrosarcoma without available MRI were considered. The localization, calcification of tumor matrix, periosteal reaction, cortical bone and patterns of bone destruction were analyzed according to the Lodwick radiological grading system (LRGS). The signal intensity on T1- and T2-weighted sequences, characteristics of contrast enhancement, associated bone marrow edema, soft tissue reaction and joint involvement were evaluated. Histopathological specimens were available in all cases. Results: The age of patients with chondroblastoma (range 15-59 years, mean 22.3 years) was lower than that of those with clear cell chondrosarcoma (range 19-61 years, mean 36.6 years), and the lesions were smaller in the chondroblastoma group (range 1-4 cm, mean 2.3 cm) than in patients with clear cell chondrosarcoma (range 3-7.5 cm, mean 5.2 cm). The chondroblastomas were more confined to the epiphysis (10/12) than the clear cell chondrosarcomas. All chondroblastomas and clear cell chondrosarcomas except one were classified as grade 1A or 1B according to the LRGS; one clear cell chondrosarcoma was judged as grade 2. Signal intensity of the tumors on MRI was very heterogeneous in both groups. High signal intensity on T2-weighted MR images in chondroblastoma mostly corresponded to areas with aneurysmal bone cyst components and in clear cell chondrosarcoma to islands of hyaline cartilage. Contrast enhancement occurred in all tumors and tended to be more intense with clear cell

  11. Possibility of increasing the efficiency of laser-induced tattoo removal by optical skin clearing

    Science.gov (United States)

    Genina, E. A.; Bashkatov, A. N.; Tuchin, V. V.; Altshuler, G. B.; Yaroslavskii, I. V.

    2008-06-01

    The possibility of selective laser photothermolysis improvement for the removal of tattoo pigments due to the optical clearing of human skin is investigated. It is shown experimentally that the optical skin clearing increases the tattoo image contrast. Computer Monte Carlo simulations show that by decreasing the laser beam scattering in upper skin layers, it is possible to reduce the radiation power required for tattoo removal by 30%—40% and, therefore, to increase the the photothermolysis efficiency.

  12. On Clear-Cut Mapping with Time-Series of Sentinel-1 Data in Boreal Forest

    Science.gov (United States)

    Rauste, Yrjo; Antropov, Oleg; Mutanen, Teemu; Hame, Tuomas

    2016-08-01

    Clear-cutting is the most drastic and wide-spread change that affects the hydrological and carbon-balance proper- ties of forested land in the Boreal forest zone1.A time-series of 36 Sentinel-1 images was used to study the potential for mapping clear-cut areas. The time series covered one and half year (2014-10-09 ... 2016-03-20) in a 200-km-by-200-km study site in Finland. The Sentinel- 1 images were acquired in Interferometric Wide-swath (IW), dual-polarized mode (VV+VH). All scenes were acquired in the same orbit configuration. Amplitude im- ages (GRDH product) were used. The Sentinel-1 scenes were ortho-rectified with in-house software using a digi- tal elevation model (DEM) produced by the Land Survey of Finland. The Sentinel-1 amplitude data were radio- metrically corrected for topographic effects.The temporal behaviour of C-band backscatter was stud- ied for areas representing 1) areas clear-cut during the ac- quisition of the Sentinel-1 time-series, 2) areas remaining forest during the acquisition of the Sentinel-1 time-series, and 3) areas that had been clear-cut before the acquisition of the Sentinel-1 time-series.The following observations were made:1. The separation between clear-cut areas and forest was generally low;2. Under certain acquisition conditions, clear-cut areas were well separable from forest;3. The good scenes were acquired: 1) in winter during thick snow cover, and 2) in late summer towards the end of a warm and dry period;4. The separation between clear-cut and forest was higher in VH polarized data than in VV-polarized data.5. The separation between clear-cut and forest was higher in the winter/snow scenes than in the dry summer scenes.

  13. Clear cell odontogenic carcinoma: case report with immunohistochemical findings adding support to the challenging diagnosis

    OpenAIRE

    XAVIER, FLÁVIA CALÓ AQUINO; Rodini, Camila Oliveira; Ramalho,Luciana Maria Pedreira; Sarmento,Viviane Almeida; Nunes, Fabio Daumas

    2008-01-01

    Acesso restrito: Texto completo. p. 403-410 Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic tumor associated with aggressive clinical behavior, metastasis, and low survival. We report a case of CCOC affecting the mandible of a 39-year-old man. The tumor presented a biphasic pattern composed of clear cell nests intermingled with eosinophilic cells and separated by collagenous stroma. Immunoreactivity to cytokeratin (CK), specifically AE1/AE3 and CK 8, 14, 18, and 19 was fou...

  14. The pollen tube clear zone:Clues to the mechanism of polarized growth

    Institute of Scientific and Technical Information of China (English)

    Peter K Hepler; Lawrence J Winship

    2015-01-01

    Pollen tubes usually exhibit a prominent region at their apex called the “clear zone” because it lacks light refracting amyloplasts. A robust, long clear zone often associates with fast growing pollen tubes, and thus serves as an indicator of pollen tube health. Nevertheless we do not understand how it arises or how it is maintained. Here we review the structure of the clear zone, and attempt to explain the factors that contribute to its formation. While amyloplasts and vacuolar elements are excluded from the clear zone, virtually all other organelles are present including secretory vesicles, mitochondria, Golgi dictyosomes, and the endoplas-mic reticulum (ER). Secretory vesicles aggregate into an inverted cone appressed against the apical plasma membrane. ER elements move nearly to the extreme apex, whereas mitochondria and Golgi dictyosomes move less far forward. The cortical actin fringe assumes a central position in the control of clear zone formation and maintenance, given its role in generating cytoplasmic streaming. Other likely factors include the tip-focused calcium gradient, the apical pH gradient, the influx of water, and a host of signaling factors (small G-proteins). We think that the clear zone is an emergent property that depends on the interaction of several factors crucial for polarized growth.

  15. Indications on continued nitrogen uptake in Scots pine roots after clear-felling

    Energy Technology Data Exchange (ETDEWEB)

    Albrektson, A.; Valinger, E.; Leijon, B.; Sjoegren, H.; Sonesson, J.

    1997-11-01

    A study was performed in a 150 years old Scots pine (Pinus sylvestris L.) stand situated on a sandy moor in northern Sweden. Two plots were to be compared, and in June 1993 one was clear-felled. Even if reduced with approximately 50%, a significant fine root (diameter < 2 mm) growth was noticed at least up to one year after the clear-felling. For medium roots (diameters 2-4 and 4-6 mm) nitrogen content in root-wood and root-bark samples from the clear-felling, as compared to the reference plot, were 30-50% higher two months after the clear-felling. The difference did not increase in later comparisons. N-content in bark and wood buttress did not differ during the period studied, except for a higher percentage in bark at the clear-felling after two summers. This was believed to be a result of decomposition. The results indicate a maintained physiological activity in the stump-root system of Scots pine at least for one year at this site. An active uptake of N in roots of cut trees may influence leaching after clear-felling, the forage value of roots, and root decomposition rate and also maintain root competition with standing trees after thinning. 40 refs, 1 fig, 2 tabs

  16. Some results on 4m2n designs with clear two-factor interaction components

    Institute of Scientific and Technical Information of China (English)

    ZHAO ShengLi; ZHANG RunChu; LIU MinQian

    2008-01-01

    Clear effects criterion is one of the important rules for selecting optimal fractional factorial designs, and it has become an active research issue in recent years.Tang et al. derived upper and lower bounds on the maximum number of clear two-factor interactions (2fi's) in 2n-(n-k)fractional factorial designs of resolutions Ⅲ and Ⅳ by constructing a 2n-(n-k) design for given k, which are only restricted for the symmetrical case. This paper proposes and studies the clear effects problem for the asymmetrical case. It improves the construction method of Tang et al. for 2n-(n-k)designs with resolution Ⅲ and derives the upper and lower bounds on the maximum number of clear two-factor interaction components(2fic's) in 4m2n designs with resolutions Ⅲ and Ⅳ. The lower bounds are achieved by constructing specific designs. Comparisons show that the number of clear 2fic's in the resulting design attains its maximum number in many cases, which reveals that the construction methods are satisfactory when they are used to construct 4m2n designs under the clear effects criterion.

  17. The Dynamics of Orbit-Clearing for Planets on Eccentric Orbits

    Science.gov (United States)

    Hastings, Danielle; Margot, Jean-Luc

    2016-10-01

    The third requirement in the 2006 International Astronomical Union (IAU) definition of a planet is that the object has cleared the neighborhood around its orbit. Margot (2015) proposed a metric that quantitatively determines if an object has enough mass to clear an orbital zone of a specific extent within a defined time interval. In this metric, the size of the zone to be cleared is given by CRH, where C is a constant and RH is the Hill Radius. Margot (2015) adopts C=2*31/2 to describe the minimum extent of orbital clearing on the basis of the planet's feeding zone. However, this value of C may only apply for eccentricities up to about 0.3 (Quillen & Faber 2006). Here, we explore the timescales and boundaries of orbital clearing for planets over a range of orbital eccentricities and planet-star mass ratios using the MERCURY integration package (Chambers 1999). The basic setup for the integrations includes a single planet orbiting a star and a uniform distribution of massless particles extending beyond CRH. The system is integrated for at least 106 revolutions and the massless particles are tracked in order to quantify the timescale and extent of the clearing.

  18. Clearing and dissecting insects for internal skeletal morphological research with particular reference to bees

    Directory of Open Access Journals (Sweden)

    Diego Sasso Porto

    2016-03-01

    Full Text Available ABSTRACT A detailed protocol for chemical clearing of bee specimens is presented. Dry specimens as well as those preserved in liquid media can be cleared using this protocol. The procedure consists of a combined use of alkaline solution (KOH or NaOH and hydrogen peroxide (H2O2, followed by the boiling of the cleared specimens in 60–70% EtOH. Clearing is particularly useful for internal skeletal morphological research. This procedure allows for efficient study of internal projections of the exoskeleton (e.g., apodemes, furcae, phragmata, tentoria, internal ridges and sulci, but this process makes external features of the integument, as some sutures and sulci, readily available for observation as well. Upon completion of the chemical clearing process the specimens can be stored in glycerin. This procedure was developed and evaluated for the preparation of bees and other Apoidea, but modifications for use with other insect taxa should be straightforward after some experimentation on variations of timing of steps, concentration of solutions, temperatures, and the necessity of a given step. Comments on the long-term storage, morphological examination, and photodocumentation of cleared specimens are also provided.

  19. Elevated-temperature-induced acceleration of PACT clearing process of mouse brain tissue

    Science.gov (United States)

    Yu, Tingting; Qi, Yisong; Zhu, Jingtan; Xu, Jianyi; Gong, Hui; Luo, Qingming; Zhu, Dan

    2017-01-01

    Tissue optical clearing technique shows a great potential for neural imaging with high resolution, especially for connectomics in brain. The passive clarity technique (PACT) is a relative simple clearing method based on incubation, which has a great advantage on tissue transparency, fluorescence preservation and immunostaining compatibility for imaging tissue blocks. However, this method suffers from long processing time. Previous studies indicated that increasing temperature can speed up the clearing. In this work, we aim to systematacially and quantitatively study this influence based on PACT with graded increase of temperatures. We investigated the process of optical clearing of brain tissue block at different temperatures, and found that elevated temperature could accelerate the clearing process and also had influence on the fluorescence intensity. By balancing the advantages with drawbacks, we conclude that 42–47 °C is an alternative temperature range for PACT, which can not only produce faster clearing process, but also retain the original advantages of PACT by preserving endogenous fluorescence well, achieving fine morphology maintenance and immunostaining compatibility. PMID:28139694

  20. Estimation of hourly clear-sky solar radiation for P. D. R. Yemen

    Energy Technology Data Exchange (ETDEWEB)

    Abdul Aziz, G.M. (Aden Univ., (P.D.R. Yemen) Faculty of Engineering)

    1990-01-01

    Monthly average hourly clear sky solar radiation for some principal stations in P.D.R. Yemen are evaluated. Hottel's model is used to predict the hourly clear sky beam and horizontal solar radiation and that of Liu and Jordan for the estimation of clear sky diffuse radiation. The two methods are combined to obtain the clear sky total radiation. Maximum and minimum clear sky total solar radiation are evaluated. The maxima are situated between 21.0 MJ/m{sup 2} and 26.6 MJ/m{sup 2}, minima between 15.0 MJ/m{sup 2} and 19.1 MJ/m{sup 2} for Aden and Mukairas respectively. Mean hourly clear-sky solar radiation are computed and discussed. 75% of the estimated radiation on a horizontal surface is obtained between 9 a.m.-3 p.m. The average intensity is about 700 W.m{sup 2} for Aden and 900 W/m{sup 2} for Mukairas. (author).

  1. Elevated-temperature-induced acceleration of PACT clearing process of mouse brain tissue

    Science.gov (United States)

    Yu, Tingting; Qi, Yisong; Zhu, Jingtan; Xu, Jianyi; Gong, Hui; Luo, Qingming; Zhu, Dan

    2017-01-01

    Tissue optical clearing technique shows a great potential for neural imaging with high resolution, especially for connectomics in brain. The passive clarity technique (PACT) is a relative simple clearing method based on incubation, which has a great advantage on tissue transparency, fluorescence preservation and immunostaining compatibility for imaging tissue blocks. However, this method suffers from long processing time. Previous studies indicated that increasing temperature can speed up the clearing. In this work, we aim to systematacially and quantitatively study this influence based on PACT with graded increase of temperatures. We investigated the process of optical clearing of brain tissue block at different temperatures, and found that elevated temperature could accelerate the clearing process and also had influence on the fluorescence intensity. By balancing the advantages with drawbacks, we conclude that 42–47 °C is an alternative temperature range for PACT, which can not only produce faster clearing process, but also retain the original advantages of PACT by preserving endogenous fluorescence well, achieving fine morphology maintenance and immunostaining compatibility.

  2. Establishment of a clean chemistry laboratory at JAERI. Clean laboratory for environmental analysis and research (CLEAR)

    Energy Technology Data Exchange (ETDEWEB)

    Hanzawa, Yukiko; Magara, Masaaki; Watanabe, Kazuo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment] [and others

    2003-02-01

    The JAERI has established a facility with a cleanroom: the Clean Laboratory for Environmental Analysis and Research (CLEAR). This report is an overview of the design, construction and performance evaluation of the CLEAR in the initial stage of the laboratory operation in June 2001. The CLEAR is a facility to be used for analyses of ultra trace amounts of nuclear materials in environmental samples for the safeguards, for the CTBT verification and for researches on environmental sciences. One of the special features of the CLEAR is that it meets double requirements of a cleanroom and for handling of nuclear materials. As another feature of the CLEAR, much attention was paid to the construction materials of the cleanroom for trace analysis of metal elements using considerable amounts of corrosive acids. The air conditioning and purification system, specially designed experimental equipment to provide clean work surfaces, utilities and safety systems are also demonstrated. The potential contamination from the completed cleanroom atmosphere during the analytical procedure was evaluated. It can be concluded that the CLEAR has provided a suitable condition for reliable analysis of ultra trace amounts of nuclear materials and other heavy elements in environmental samples. (author)

  3. Some results on 4~m2~n designs with clear two-factor interaction components

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Clear effects criterion is one of the important rules for selecting optimal fractional factorial designs,and it has become an active research issue in recent years.Tang et al.derived upper and lower bounds on the maximum number of clear two-factor interactions(2fi’s) in 2n-(n-k) fractional factorial designs of resolutions III and IV by constructing a 2n-(n-k) design for given k,which are only restricted for the symmetrical case.This paper proposes and studies the clear effects problem for the asymmetrical case.It improves the construction method of Tang et al.for 2n-(n-k) designs with resolution III and derives the upper and lower bounds on the maximum number of clear two-factor interaction components(2fic’s) in 4m2n designs with resolutions III and IV.The lower bounds are achieved by constructing specific designs.Comparisons show that the number of clear 2fic’s in the resulting design attains its maximum number in many cases,which reveals that the construction methods are satisfactory when they are used to construct 4m2n designs under the clear effects criterion.

  4. Infectivity of Arbuscular Mycorrhizal Fungi in Naturally Regenerating, Unmanaged and Clear-Cut Beech Forests

    Institute of Scientific and Technical Information of China (English)

    I.CLOSA; N.GOICOECHEA

    2011-01-01

    Clear-cutting, a management practice applied to many beech forests in the North of Spain, modifies microclimate and, consequently,the composition of the understory plant community in the disturbed areas. The objectives of this study were to assess if changes in the understory vegetation caused by altered light microclimate after clear-cutting affect the infectivity of arbuscular mycorrhizal fungi (AMF) on herbaceous plant species in beech (Fagus sylvatica L.) forests naturally regenerating from clear-cutting and to test if the use of bioassays for studying the infectivity of native AMF could provide aseful information to improve the management of clear-cut areas.Three nearby beech forests in northwest Navarra, Spain, a region in the northwest part of the Pyrenees, were selected: an unmanaged forest, a forest clear-cut in 1996, and another forest clear-cut in 2001. High stem density in the forest clear-cut in 1996 (44 000 trees ha-1) attenuated photosynthetic active radiation (PAR) and impaired the growth of herbaceous species within the ecosystem. The percentage of AMF colonization of plants in bioassays performed on soil samples collected from the forest clear-cut in 1996 was always lower than 10%. In the forest clear-cut in 2001, where soil was covered by perennial grasses, PAR was high and thc infectivity of native AMF achieved minimum values in spring and autumn and a maximum value in summer. In contrast, the infectivity of native AMF in the umnanaged forest remained similar across the seasons. Our results demonstrated that changes in the composition of understory vegetation within beech forests strongly affected the infectivity of native AMF in clear-cut areas and suggested that the assessment of the infectivity of native AMF through bioassays could provide helpful information for planning either the removal of overstory when the tree density is so high that it impairs the correct development of herbaceous species or the plantation of new sesdlings when high

  5. Functional imaging in bulk tissue specimens using optical emission tomography: fluorescence preservation during optical clearing

    Science.gov (United States)

    Sakhalkar, H. S.; Dewhirst, M.; Oliver, T.; Cao, Y.; Oldham, M.

    2007-04-01

    Optical emission computed tomography (optical-ECT) is a technique for imaging the three-dimensional (3D) distribution of fluorescent probes in biological tissue specimens with high contrast and spatial resolution. In optical-ECT, functional information can be imaged by (i) systemic application of functional labels (e.g. fluorophore labelled proteins) and/or (ii) endogenous expression of fluorescent reporter proteins (e.g. red fluorescent protein (RFP), green fluorescent protein (GFP)) in vivo. An essential prerequisite for optical-ECT is optical clearing, a procedure where tissue specimens are made transparent to light by sequential perfusion with fixing, dehydrating and clearing agents. In this study, we investigate clearing protocols involving a selection of common fixing (4% buffered paraformaldehyde (PFA), methanol and ethanol), dehydrating (methanol and ethanol) and clearing agents (methyl salicylate and benzyl-alcohol-benzyl-benzoate (BABB)) in order to determine a 'fluorescence friendly' clearing procedure. Cell culture experiments were employed to optimize the sequence of chemical treatments that best preserve fluorescence. Texas red (TxRed), fluorescein isothiocyanate (FITC), RFP and GFP were tested as fluorophores and fluorescent reporter proteins of interest. Fluorescent and control cells were imaged on a microscope using a DSred2 and FITC filter set. The most promising clearing protocols of cell culture experiments were applied to whole xenograft tumour specimens, to test their effectiveness in large unsectioned samples. Fluorescence of TxRed/FITC fluorophores was not found to be significantly affected by any of the test clearing protocols. RFP and GFP fluorescence, however, was found to be significantly greater when cell fixation was in ethanol. Fixation in either PFA or methanol resulted in diminished fluorescence. After ethanol fixation, the RFP and GFP fluorescence proved remarkably robust to subsequent exposure to either methyl salicylate or BABB

  6. The role of aerosol absorption in driving clear-sky solar dimming over East Asia

    Science.gov (United States)

    Persad, Geeta G.; Ming, Yi; Ramaswamy, V.

    2014-09-01

    Surface-based observations indicate a significant decreasing trend in clear-sky downward surface solar radiation (SSR) over East Asia since the 1960s. This "dimming" is thought to be driven by the region's long-term increase in aerosol emissions, but little work has been done to quantify the underlying physical mechanisms or the contribution from aerosol absorption within the atmospheric column. Given the distinct climate impacts that absorption-driven dimming may produce, this constitutes an important, but thus far rather neglected, line of inquiry. We examine experiments conducted in the Geophysical Fluid Dynamics Laboratory's atmospheric general circulation models, AM2.1 and AM3, in order to analyze the model-simulated East Asian clear-sky SSR trends. We also use the models' stand-alone radiation module to examine the contribution from various aerosol characteristics in the two models (such as burden, mixing state, hygroscopicity, and seasonal distribution) to the trends. Both models produce trends in clear-sky SSR that are comparable to that observed but via disparate mechanisms. Despite their different aerosol characteristics, the models produce nearly identical increases in aerosol absorption since the 1960s, constituting as much as half of the modeled clear-sky dimming. This is due to a compensation between the differences in aerosol column burden and mixing state assumed in the two models, i.e., plausible clear-sky SSR simulations can be achieved via drastically different aerosol parameterizations. Our novel results indicate that trends in aerosol absorption drive a large portion of East Asian clear-sky solar dimming in the models presented here and for the time periods analyzed and that mechanistic analysis of the factors involved in aerosol absorption is an important diagnostic in evaluating modeled clear-sky solar dimming trends.

  7. 78 FR 40243 - Self-Regulatory Organizations; ICE Clear Europe Limited; Notice of Filing of Amendment No. 3 and...

    Science.gov (United States)

    2013-07-03

    ...., credit default swap) clearing business. ICE Clear Europe believes the clearing of LIFFE Contracts will... to its security-based swap related (i.e., credit default swap) clearing business. Moreover, new... market, default risk (including sovereign risk) with respect to those assets, relevant foreign...

  8. The effect of environmental degradation on the characterisation of automotive clear coats by infrared spectroscopy.

    Science.gov (United States)

    van der Pal, Karin J; Sauzier, Georgina; Maric, Mark; van Bronswijk, Wilhelm; Pitts, Kari; Lewis, Simon W

    2016-02-01

    This paper presents a study into the chemical changes occurring within automotive clear coats as a result of environmental weathering, and their potential effect upon the characterisation of samples using infrared spectroscopy combined with chemometric modelling. Testing of three samples, collected from separate vehicles, exposed to the outside environment revealed no changes in model predictions over a 175 day period; however, incorrect predictions were observed following 435 days of exposure. Inspection of the corresponding infrared spectra revealed that these changes were likely due to the hydrolysis and photodegradation of polymer chains present in the clear coat, which were not observed in samples stored away from the outside environment over a one-year period. Analysis of previously weathered samples using synchrotron infrared microscopy found these changes occurred in a top-down fashion rather than within the bulk of the clear coat. This indicates that although weathering may affect the surface characterisation of clear coats over time, the targeting of deeper portions of the clear coat layer may still provide useful information as to the identity of the vehicle.

  9. Large-scale tissue clearing (PACT): Technical evaluation and new perspectives in immunofluorescence, histology, and ultrastructure

    Science.gov (United States)

    Neckel, Peter H.; Mattheus, Ulrich; Hirt, Bernhard; Just, Lothar; Mack, Andreas F.

    2016-01-01

    Novel techniques, like CLARITY and PACT, render large tissue specimens transparent and thereby suitable for microscopic analysis. We used these techniques to evaluate their potential in the intestine as an exemplary organ with a complex tissue composition. Immunohistochemistry, light sheet-, and confocal scanning-microscopy enabled us to follow complex three-dimensional structures, like nerve fibers, vessels, and epithelial barriers throughout the entire organ. Moreover, in a systematic electron microscopic study, we analyzed the morphology and preservation of tissue on ultrastructural level during the clearing process. We also connect tissue clearing with classical histology and demonstrate that cleared tissues can be stained with Hematoxylin-Eosin and Heidenhain’s Azan stain, suggesting potential use in histopathology. These experiments showed that a neutral pH during the clearing process results in much better preservation of tissue ultrastructure and standard stainability. Volume changes of specimens were monitored and quantified during the course of the protocol. Additionally, we employed the technique to visualize the enteric nervous system and the epithelial barrier in post mortem human gut preparations. Our data show the high potential of tissue clearing throughout different tissue types supporting its usefulness in research and diagnosis, and contribute to the technical discussion of ultrastructural tissue-retention. PMID:27680942

  10. Aerosol optical depth under "clear" sky conditions derived from sea surface reflection of lidar signals.

    Science.gov (United States)

    He, Min; Hu, Yongxiang; Huang, Jian Ping; Stamnes, Knut

    2016-12-26

    There are considerable demands for accurate atmospheric correction of satellite observations of the sea surface or subsurface signal. Surface and sub-surface reflection under "clear" atmospheric conditions can be used to study atmospheric correction for the simplest possible situation. Here "clear" sky means a cloud-free atmosphere with sufficiently small aerosol particles. The "clear" aerosol concept is defined according to the spectral dependence of the scattering cross section on particle size. A 5-year combined CALIPSO and AMSR-E data set was used to derive the aerosol optical depth (AOD) from the lidar signal reflected from the sea surface. Compared with the traditional lidar-retrieved AOD, which relies on lidar backscattering measurements and an assumed lidar ratio, the AOD retrieved through the surface reflectance method depends on both scattering and absorption because it is based on two-way attenuation of the lidar signal transmitted to and then reflected from the surface. The results show that the clear sky AOD derived from the surface signal agrees with the clear sky AOD available in the CALIPSO level 2 database in the westerly wind belt located in the southern hemisphere, but yields significantly higher aerosol loadings in the tropics and in the northern hemisphere.

  11. Comparison of the observed and calculated clear sky greenhouse effect - Implications for climate studies

    Science.gov (United States)

    Kiehl, J. T.; Briegleb, B. P.

    1992-01-01

    The clear sky greenhouse effect is defined in terms of the outgoing longwave clear sky flux at the top of the atmosphere. Recently, interest in the magnitude of the clear sky greenhouse effect has increased due to the archiving of the clear sky flux quantity through the Earth Radiation Budget Experiment (ERBE). The present study investigates to what degree of accuracy this flux can be analyzed by using independent atmospheric and surface data in conjunction with a detailed longwave radiation model. The conclusion from this comparison is that for most regions over oceans the analyzed fluxes agree to within the accuracy of the ERBE-retrieved fluxes (+/- 5 W/sq m). However, in regions where deep convective activity occurs, the ERBE fluxes are significantly higher (10-15 W/sq m) than the calculated fluxes. This bias can arise from either cloud contamination problems or variability in water vapor amount. It is argued that the use of analyzed fluxes may provide a more consistent clear sky flux data set for general circulation modeling validation. Climate implications from the analyzed fluxes are explored. Finally, results for obtaining longwave surface fluxes over the oceans are presented.

  12. Imaging cleared intact biological systems at a cellular level by 3DISCO.

    Science.gov (United States)

    Ertürk, Ali; Lafkas, Daniel; Chalouni, Cecile

    2014-07-07

    Tissue clearing and subsequent imaging of transparent organs is a powerful method to analyze fluorescently labeled cells and molecules in 3D, in intact organs. Unlike traditional histological methods, where the tissue of interest is sectioned for fluorescent imaging, 3D imaging of cleared tissue allows examination of labeled cells and molecules in the entire specimen. To this end, optically opaque tissues should be rendered transparent by matching the refractory indices throughout the tissue. Subsequently, the tissue can be imaged at once using laser-scanning microscopes to obtain a complete high-resolution 3D image of the specimen. A growing list of tissue clearing protocols including 3DISCO, CLARITY, Sca/e, ClearT2, and SeeDB provide new ways for researchers to image their tissue of interest as a whole. Among them, 3DISCO is a highly reproducible and straightforward method, which can clear different types of tissues and can be utilized with various microscopy techniques. This protocol describes this straightforward procedure and presents its various applications. It also discusses the limitations and possible difficulties and how to overcome them.

  13. Quantitative analysis of dehydration in porcine skin caused by optical clearing agents

    Science.gov (United States)

    Yu, Tingting; Wen, Xiang; Duan, Shu; Zhu, Dan

    2010-11-01

    Dehydration is supposed to be one of mechanisms of optical clearing, but current studies merely gave some qualitative descriptions. Here an analysis method was established to evaluate the water content of skin with PLS method based on the measurements of near-infrared reflectance spectroscopy and weight of porcine skin. Furthermore, a commercial spectrometer with integrating sphere was used to measure the reflectance and transmittance after treatment with different agents. Then the established method was used to evaluate the water content, while the Inverse Adding-Double algorithm was used to calculate the reduced scattering coefficients. The results show that both the water contents and reduced scattering coefficients decrease during the optical clearing process, and there is direct relationship between the optical clearing efficacy and dehydration. With the treating time last, the relative change in reduced scattering coefficient is larger than that in dehydration of skin, and the difference between the changes depends on the agents. Therefore, we conclude that dehydration is the main mechanism of skin optical clearing during the 60 min treatment of the agents, but for some OCAs, i.e., PEG400, glycerol, or D-sorbitol, there might be some other mechanisms contributing to the optical clearing efficacy.

  14. Laser Scanning In Vivo Confocal Microscopy of Clear Grafts after Penetrating Keratoplasty

    Science.gov (United States)

    Wang, Dai; Song, Peng; Wang, Shuting; Sun, Dapeng; Wang, Yuexin; Zhang, Yangyang

    2016-01-01

    Purpose. To evaluate the changes of keratocytes and dendritic cells in the central clear graft by laser scanning in vivo confocal microscopy after penetrating keratoplasty (PK). Methods. Thirty adult subjects receiving PK at Shandong Eye Institute and with clear grafts and no sign of immune rejection after surgery were recruited into this study, and 10 healthy adults were controls. The keratocytes and dendritic cells in the central graft were evaluated by laser scanning confocal microscopy, as well as epithelium cells, keratocytes, corneal endothelium cells, and corneal nerves (especially subepithelial plexus nerves). Results. Median density of subepithelial plexus nerves, keratocyte density in each layer of the stroma, and density of corneal endothelium cells were all lower in clear grafts than in controls. The dendritic cells of five (16.7%) patients were active in Bowman's membrane and stromal membrane of the graft after PK. Conclusions. Activated dendritic cells and Langerhans cells could be detected in some of the clear grafts, which indicated that the subclinical stress of immune reaction took part in the chronic injury of the clear graft after PK, even when there was no clinical rejection episode. PMID:27034940

  15. Laser Scanning In Vivo Confocal Microscopy of Clear Grafts after Penetrating Keratoplasty

    Directory of Open Access Journals (Sweden)

    Dai Wang

    2016-01-01

    Full Text Available Purpose. To evaluate the changes of keratocytes and dendritic cells in the central clear graft by laser scanning in vivo confocal microscopy after penetrating keratoplasty (PK. Methods. Thirty adult subjects receiving PK at Shandong Eye Institute and with clear grafts and no sign of immune rejection after surgery were recruited into this study, and 10 healthy adults were controls. The keratocytes and dendritic cells in the central graft were evaluated by laser scanning confocal microscopy, as well as epithelium cells, keratocytes, corneal endothelium cells, and corneal nerves (especially subepithelial plexus nerves. Results. Median density of subepithelial plexus nerves, keratocyte density in each layer of the stroma, and density of corneal endothelium cells were all lower in clear grafts than in controls. The dendritic cells of five (16.7% patients were active in Bowman’s membrane and stromal membrane of the graft after PK. Conclusions. Activated dendritic cells and Langerhans cells could be detected in some of the clear grafts, which indicated that the subclinical stress of immune reaction took part in the chronic injury of the clear graft after PK, even when there was no clinical rejection episode.

  16. Increasing the penetration depth for ultrafast laser tissue ablation using glycerol based optical clearing

    Science.gov (United States)

    Gabay, Ilan; Subramanian, Kaushik G.; Martin, Chris; Yildirim, Murat; Tuchin, Valery V.; Ben-Yakar, Adela

    2016-03-01

    Background: Deep tissue ablation is the next challenge in ultrafast laser microsurgery. By focusing ultrafast pulses below the tissue surface one can create an ablation void confined to the focal volume. However, as the ablation depth increases in a scattering tissue, increase in the required power can trigger undesired nonlinear phenomena out of focus that restricts our ability to ablate beyond a maximum ablation depth of few scattering lengths. Optical clearing (OC) might reduce the intensity and increase the maximal ablation depth by lowering the refractive index mismatch, and therefore reducing scattering. Some efforts to ablate deeper showed out of focus damage, while others used brutal mechanical methods for clearing. Our clinical goal is to create voids in the scarred vocal folds and inject a biomaterial to bring back the tissue elasticity and restore phonation. Materials and methods: Fresh porcine vocal folds were excised and applied a biocompatible OC agent (75% glycerol). Collimated transmittance was monitored. The tissue was optically cleared and put under the microscope for ablation threshold measurements at different depths. Results: The time after which the tissue was optically cleared was roughly two hours. Fitting the threshold measurements to an exponential decay graph indicated that the scattering length of the tissue increased to 83+/-16 μm, which is more than doubling the known scattering length for normal tissue. Conclusion: Optical clearing with Glycerol increases the tissue scattering length and therefore reduces the energy for ablation and increases the maximal ablation depth. This technique can potentially improve clinical microsurgery.

  17. An Improved Clearing and Mounting Solution to Replace Chloral Hydrate in Microscopic Applications

    Directory of Open Access Journals (Sweden)

    Thomas S. Villani

    2013-05-01

    Full Text Available Premise of the study: This study presents Visikol™, a new proprietary formulation that can be used as an efficient replacement for chloral hydrate as a clearing agent for microscopic examination. In the United States, chloral hydrate is regulated and therefore difficult to acquire. Methods and Results: Fresh and dry samples of the following plants: ginger (Zingiber officinale, maté (Ilex paraguariensis, lime basil (Ocimum americanum, oregano (Origanum vulgare, and mouse-ear cress (Arabidopsis thaliana, were cleared using Visikol or chloral hydrate solution and compared using a light microscope. Conclusions: This new method can be used successfully to clear specimens, allowing identification of diagnostic characteristics for the identification of plant materials. Visikol is as effective as chloral hydrate in providing clarity and resolution of all tissues examined. Tissues become transparent, allowing observation of deeper layers of cells and making it effective in research, botanical and quality control, and for educational applications.

  18. Recent Findings Based on Airborne Measurements at the Interface of Coastal California Clouds and Clear Air

    Science.gov (United States)

    Sorooshian, A.; Crosbie, E.; Wang, Z.; Chuang, P. Y.; Craven, J. S.; Coggon, M. M.; Brunke, M.; Zeng, X.; Jonsson, H.; Woods, R. K.; Flagan, R. C.; Seinfeld, J.

    2015-12-01

    Recent aircraft field experiments with the Center for Interdisciplinary Remotely Piloted Aircraft Studies (CIRPAS) Twin Otter have targeted interfaces between clear and cloudy areas along the California coast. These campaigns, based out of Marina, California in the July-August time frame, include the Eastern Pacific Emitted Aerosol Cloud Experiment (E-PEACE, 2011), Nucleation in California Experiment (NiCE, 2013), and the Biological Ocean Atmospheric Study (BOAS, 2015). Results will be presented related to (i) aqueous processing of natural and anthropogenic emissions, (ii) vertical re-distribution of ocean micronutrients, and (iii) stratocumulus cloud clearings and notable thermodynamic and aerosol contrasts across the clear-cloudy interface. The results have implications for modeling and observational studies of marine boundary layer clouds, especially in relation to aerosol-cloud interactions.

  19. Simulation results of a veto counter for the ClearPEM

    CERN Document Server

    Trummer, J; Lecoq, P

    2009-01-01

    The Crystal Clear Collaboration (CCC) has built a prototype of a novel positron emission tomograph dedicated to functional breast imaging, the ClearPEM. The ClearPEM uses the common radio pharmaceutical FDG for imaging cancer. As FDG is a rather non-specific radio tracer, it accumulates not only in cancer cells but in all cells with a high energy consumption, such as the heart and liver. This fact poses a problem especially in breast imaging, where the vicinity of the heart and other organs to the breast leads to a high background noise level in the scanner. In this work, a veto counter to reduce the background is described. Different configurations and their effectiveness were studied using the GATE simulation package.

  20. Solar cell process development in the European integrated project CrystalClear

    Energy Technology Data Exchange (ETDEWEB)

    Beaucarne, G.; John, J.; Choulat, P.; Ma, Y. [IMEC vzw, Kapeldreef 75, B-3001 Leuven (Belgium); Russel, R. [BP Solar Espana, Madrid (Spain); Romijn, I.; Weeber, A. [ECN Solar Energy, PO Box 1, NL 1755 ZG Petten (Netherlands); Hofmann, M.; Preu, R. [Fraunhofer Institute for Solar Energy Systems ISE, Heidenhofstr. 2, 79110 Freiburg (Germany); Slaoui, A. [InESS, Strassbourg (France); Le Quang, N.; Nichiporuk, O. [Photowatt Technologies, Bourgoin-Jallieu (France); Del Caoizo, C; Pan, A. [Polytechnical University of Madrid, Madrid (Spain); Solheim, H.; Evju, J. [REC Scancell, Sandvika (Norway); Nagel, H.; Horzel, J. [SCHOTT Solar, Alzenau (Germany); Bitnar, B.; Heemeier, M.; Weber, T. [SolarWorld, Freiberg/Sachsen (Germany); Raabe, B.; Haverkamp, H.; Struempel, C.; Junge, J.; Riegel, S.; Seren, S.; Hahn, G. [University of Konstanz, Department of Physics, P.O.Box X916, 78457 Konstanz (Germany)

    2008-10-15

    CrystalClear is a large integrated project funded by the European Commission that aims to drastically reduce the cost of crystalline Si PV modules, down to 1 Euro/Wp. Among the different subprojects, the one dealing with the development of advanced solar cells is relatively large (with 11 partners out of the 15 Crystal Clear partners taking part) and has a crucial role. The goal of the subproject is to develop cell design concepts and manufacturing processes that would enable a reduction in the order of 40% of the cell processing costs per Wp. In this paper, we give an overview of all the development work that has taken place in the CrystalClear solar cells subproject so far. World class results have been achieved, particularly on high efficiency cells on Si ribbons, and on industrial-type solar cells on very thin (120 {mu}m thick) substrates.

  1. Primary clear cell carcinoma of parotid gland: Case report and review of literature.

    Science.gov (United States)

    Rodríguez, Marta Saldaña; Reija, Maria Fe García; Rodilla, Irene González

    2013-01-01

    Clear cell carcinoma (CCC) is a rare low-grade carcinoma that represents only 1% to 2% of all salivary glands tumors. The finding of a clear cell tumor in a parotid gland involves the necessity of differential diagnosis between primary clear cell parotid tumors and metastases, mainly from kidney. The biological behavior is not very aggressive and development, which is very slow, is usually asymptomatic and indeed, the tumor often reaches considerable dimensions before being diagnosed. The treatment of choice is the surgical excision. There are rare cases of local recurrence and distant metastases. The aim of this article is to report a primary CCC in the parotid gland that microscopically closely resembled a metastatic CCC of renal origin, making microscopic differentiation difficult.

  2. A split-electrode for clearing scattered electrons in the RHIC e-lens

    Energy Technology Data Exchange (ETDEWEB)

    Gu X.; Pikin, A.; Thieberger, P.; Fischer, W.; Hock, J.; Hamdi, K.; Gassner,D.; Luo, Y.; Montag, C.; Okamura, M.

    2012-05-20

    We are designing two electron lenses that will be installed at RHIC IR10 to compensate for the head-on beam-beam effect. To clear accumulated scattered electrons from 100 GeV proton-electron head-on collisions in the e-lens, a clearing split electrode may be constructed. The feasibility of this proposed electrode was demonstrated via the CST Particle Studio and Opera program simulations. By splitting one of the drift tubes in the e-lens and applying {approx} 380 V across the two parts, the scattered electrons can be cleared out within several hundred micro-seconds. At the same time we can restrict the unwanted shift of the primary electron-beam that already passed the 2-m interaction region in e-lens, to less than 15um.

  3. Integrative bioinformatics links HNF1B with clear cell carcinoma and tumor-associated thrombosis.

    Directory of Open Access Journals (Sweden)

    Justin Cuff

    Full Text Available Clear cell carcinoma (CCC is a histologically distinct carcinoma subtype that arises in several organ systems and is marked by cytoplasmic clearing, attributed to abundant intracellular glycogen. Previously, transcription factor hepatocyte nuclear factor 1-beta (HNF1B was identified as a biomarker of ovarian CCC. Here, we set out to explore more broadly the relation between HNF1B and carcinomas with clear cell histology. HNF1B expression, evaluated by immunohistochemistry, was significantly associated with clear cell histology across diverse gynecologic and renal carcinomas (P<0.001, as was hypomethylation of the HNF1B promoter (P<0.001. From microarray analysis, an empirically-derived HNF1B signature was significantly enriched for computationally-predicted targets (with HNF1 binding sites (P<0.03, as well as genes associated with glycogen metabolism, including glucose-6-phophatase, and strikingly the blood clotting cascade, including fibrinogen, prothrombin and factor XIII. Enrichment of the clotting cascade was also evident in microarray data from ovarian CCC versus other histotypes (P<0.01, and HNF1B-associated prothrombin expression was verified by immunohistochemistry (P = 0.015. Finally, among gynecologic carcinomas with cytoplasmic clearing, HNF1B immunostaining was linked to a 3.0-fold increased risk of clinically-significant venous thrombosis (P = 0.043, and with a 2.3-fold increased risk (P = 0.011 in a combined gynecologic and renal carcinoma cohort. Our results define HNF1B as a broad marker of clear cell phenotype, and support a mechanistic link to glycogen accumulation and thrombosis, possibly reflecting (for gynecologic CCC derivation from secretory endometrium. Our findings also implicate a novel mechanism of tumor-associated thrombosis (a major cause of cancer mortality, based on the direct production of clotting factors by cancer cells.

  4. Predicting Clear-Sky Reflectance Over Snow/Ice in Polar Regions

    Science.gov (United States)

    Chen, Yan; Sun-Mack, Sunny; Arduini, Robert F.; Hong, Gang; Minnis, Patrick

    2015-01-01

    Satellite remote sensing of clouds requires an accurate estimate of the clear-sky radiances for a given scene to detect clouds and aerosols and to retrieve their microphysical properties. Knowing the spatial and angular variability of clear-sky albedo is essential for predicting clear-sky radiance at solar wavelengths. The Clouds and the Earth's Radiant Energy System (CERES) Project uses the nearinfrared (NIR; 1.24, 1.6 or 2.13 micrometers), visible (VIS; 0.63 micrometers) and vegetation (VEG; 0.86 micrometers) channels available on the Terra and Aqua Moderate Resolution Imaging Spectroradiometer (MODIS) to help identify clouds and retrieve their properties in both snow-free and snow-covered conditions. Thus, it is critical to have reliable distributions of clear-sky albedo for all of these channels. In CERES Edition 4 (Ed4), the 1.24-micrometer channel is used to retrieve cloud optical depth over snow/ice-covered surfaces. Thus, it is especially critical to accurately predict the 1.24-micrometer clear-sky albedo alpha and reflectance rho for a given location and time. Snow albedo and reflectance patterns are very complex due to surface texture, particle shapes and sizes, melt water, and vegetation protrusions from the snow surface. To minimize those effects, this study focuses on the permanent snow cover of Antarctica where vegetation is absent and melt water is minimal. Clear-sky albedos are determined as a function of solar zenith angle (SZA) from observations over all scenes determined to be cloud-free to produce a normalized directional albedo model (DRM). The DRM is used to develop alpha(SZA=0 degrees) on 10 foot grid for each season. These values provide the basis for predicting r at any location and set of viewing & illumination conditions. This paper examines the accuracy of this approach for two theoretical snow surface reflectance models.

  5. Long-term monitoring of Dzanga Bai forest elephants: forest clearing use patterns.

    Science.gov (United States)

    Turkalo, Andrea K; Wrege, Peter H; Wittemyer, George

    2013-01-01

    Individual identification of the relatively cryptic forest elephant (Loxodonta cyclotis) at forest clearings currently provides the highest quality monitoring data on this ecologically important but increasingly threatened species. Here we present baseline data from the first 20 years of an individually based study of this species, conducted at the Dzanga Clearing, Central African Republic. A total of 3,128 elephants were identified over the 20-year study (1,244 adults; 675 females, 569 males). It took approximately four years for the majority of elephants visiting the clearing to be identified, but new elephants entered the clearing every year of the study. The study population was relatively stable, varying from 1,668 to 1,864 individuals (including juveniles and infants), with increasingly fewer males than females over time. The age-class distribution for females remained qualitatively unchanged between 1995 and 2010, while the proportion of adult males decreased from 20% to 10%, likely reflecting increased mortality. Visitation patterns by individuals were highly variable, with some elephants visiting monthly while others were ephemeral users with visits separated by multiple years. The number of individuals in the clearing at any time varied between 40 and 100 individuals, and there was little evidence of a seasonal pattern in this variation. The number of elephants entering the clearing together (defined here as a social group) averaged 1.49 (range 1-12) for males and 2.67 (range 1-14) for females. This collation of 20 years of intensive forest elephant monitoring provides the first detailed, long term look at the ecology of bai visitation for this species, offering insight to the ecological significance and motivation for bai use, social behavior, and threats to forest elephants. We discuss likely drivers (rainfall, compression, illegal killing, etc.) influencing bai visitation rates. This study provides the baseline for future demographic and behavioral

  6. The Life Cycle of Mercury Within the Clear Lake Aquatic Ecosystem: From Ore to Organism

    Science.gov (United States)

    Suchanek, T. H.; Suchanek, T. H.; Nelson, D. C.; Nelson, D. C.; Zierenberg, R. A.; King, P.; King, P.; McElroy, K.; McElroy, K.

    2001-12-01

    Clear Lake (Lake County) is located in the geologically active Clear Lake volcanics mercury (Hg) bearing Franciscan formation within the Coast Range of California, which includes over 300 abandoned Hg mines and prospects. Intermittent mining at the Sulphur Bank Mercury Mine (from 1872-1957), now a USEPA SuperFund site, has resulted in approximately 100 metric tonnes of Hg being deposited into the aquatic ecosystem of Clear Lake, with sediment concentrations of total-Hg as high as 650 mg/kg (parts per million = ppm) near the mine, making Clear Lake one of the most Hg contaminated lakes in the world. As a result, largemouth bass and other top predatory fish species often exceed both the Federal USFDA recommended maximum recommended concentrations of 1.0 ppm and the State of California level of 0.5 ppm. Acid rock drainage leaches Hg and high concentrations of sulfate from the mine site through wasterock and subsurface conduits through subsediment advection and eventually upward diffusion into lake sediments and water. When mineral-laden pH 3 fluids from the mine mix with Clear Lake water (pH 8), an alumino-silicate precipitate (floc) is produced that promotes the localized production of toxic methyl Hg. Floc "hot spots" in sediments near the mine exhibit low pH, high sulfate, anoxia and high organic loading which create conditions that promote Hg methylation by microbial activity, especially in late summer and fall. Wind-driven currents transport methyl-Hg laden floc particles throughout Clear Lake, where they are consumed by plankton and benthic invertebrates and bioaccumulated throughout the food web. While Clear Lake biota have elevated concentrations of methyl-Hg, they are not as elevated as might be expected based on the total Hg loading into the lake. A science-based management approach, utilizing over 10 years of data collected on Hg cycling within the physical and biological compartments of Clear Lake, is necessary to affect a sensible remediation plan.

  7. A Well-Clear Volume Based on Time to Entry Point

    Science.gov (United States)

    Narkawicz, Anthony J.; Munoz, Cesar A.; Upchurch, Jason M.; Chamberlain, James P.; Consiglio, Maria C.

    2014-01-01

    A well-clear volume is a key component of NASA's Separation Assurance concept for the integration of UAS in the NAS. This paper proposes a mathematical definition of the well-clear volume that uses, in addition to distance thresholds, a time threshold based on time to entry point (TEP). The mathematical model that results from this definition is more conservative than other candidate definitions of the wellclear volume that are based on range over closure rate and time to closest point of approach.

  8. Effect of Tropical Peat Swamp Forest Clearing on Soil Carbon Storage

    Directory of Open Access Journals (Sweden)

    Ahmad S.M. Nuri

    2011-01-01

    Full Text Available Problem Statement: Forest clearing in Tropical Peat Swamp Forest (TPSF will affect forest soil carbon storage. Thus this study is essential to determine whether the effect of clearing of forest does to the nature of soil forest concentrating on soil carbon storage. The objectives of this study were to analyze carbon storage values in logged and clear cut TPSF and to compare these values to see whether clearing of forest will affect its soil in terms of carbon storage. Approach: Soil sampling was conducted in July 2009 on two different plots at Batang Igan, Sibu, Sarawak, Malaysia. The plots are secondary TPSF where this area has been logged but not been cleared while another plot is the clear cut area where the forest has been cut down and cleared for other land use. Soil samples were taken in each plot in the depth of 0-15 cm. Every sample was taken randomly by peat auger using bulking method. The soils were air dried, pounded using mortar and sieved. The bulk densities were determined by coring method. Total Carbon (TC, total Organic Matter (OM, Total Nitrogen (TN and stable C estimation per hectare were determined from bulk density. The soil pH was determined using pH meter by using water and KCl. SOM, TC and stable C in Humic Acid (HA were determined by loss-on ignition method. TN was determined using Micro-Kjeldahl method followed by steam distillation and titration. HA was extracted and purified using distilled water. Then, the HA were oven dried in 40oC. The E4/E6 ratio by using spectrometer was used. Total acidity of HA which consists of carboxylic (-COOH and phenolic (-OH functional group were analyzed. The statistical analysis and comparison was using t-test to compare between two means. Results: The variables that showing the significant differences between two plots were pH water and KCl, soil OM, total C and HA yield. The insignificant differences were bulk density, total N, C/N ratio, E4/E6, phenol, carboxyl

  9. Epidermization in the esophageal mucosa: unusual epithelial changes clearly detected by Lugol's staining.

    Science.gov (United States)

    Nakanishi, Y; Ochiai, A; Shimoda, T; Yamaguchi, H; Tachimori, Y; Kato, H; Watanabe, H; Hirohashi, S

    1997-05-01

    A 58-year-old Japanese man with superficial esophageal cancer accompanied by unusual epithelial changes, including esophageal mucosal epidermization, is reported. Staining with Lugol's iodine clearly showed irregular unstained lesions, which could not be seen clearly macroscopically, in the resected specimen. Histologic examination of the irregular unstained areas showed definite granular and horny layers regarded as epidermization, acanthosis with slight nuclear enlargement, and epithelial atrophy. The immunohistochemical staining patterns of keratins in the epidermized and atrophic lesions were similar to those in the epidermis, and the keratin staining patterns of the acanthotic lesion were similar to those of the oral epithelium.

  10. Catalog of Audiovisual Productions. Volume 4. DoD Productions Cleared for Public Release

    Science.gov (United States)

    1984-06-01

    cONVENTIONAL WARFARE, THE 26062-DA UNITED STATES ARY RESEARCH AND DEVE,.1 PWENT • 21000-OF COMNAT HUNTER PHASE III 20017-OF THIRD CHALLENGE, THE... CORPORAL IN THE U,.. ARMY WHO IK, ROTION PICTURE 058 WiN 1958 - -CLEARED FOR PE, TV, tH, PS ’ UNCL WRITES HIS FATHER OF HIS FIRST VIT TO THE C PEARE...IN CAR, AND THE PERSHING AND HERCULES MISSILES CLEARED FOR PE, TV, OS UNCL MILITARY AND NON-MILITARY AREAS. HIGHLIGHTS IN COImPARISON WITH CORPORAL

  11. Clear cell papillary renal cell carcinoma: micro-RNA expression profiling and comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma.

    Science.gov (United States)

    Munari, Enrico; Marchionni, Luigi; Chitre, Apurva; Hayashi, Masamichi; Martignoni, Guido; Brunelli, Matteo; Gobbo, Stefano; Argani, Pedram; Allaf, Mohamad; Hoque, Mohammad O; Netto, George J

    2014-06-01

    Clear cell papillary renal cell carcinoma (CCPRCC) is a low-grade renal neoplasm with morphological characteristics mimicking both clear cell renal cell carcinoma (CCRCC) and papillary renal cell carcinoma (PRCC). However, despite some overlapping features, their morphological, immunohistochemical, and molecular profiles are distinct. Micro-RNAs (miRNAs) are small noncoding RNAs that play a crucial role in regulating gene expression and are involved in various biological processes, including cancer development. To better understand the biology of this tumor, we aimed to analyze the miRNA expression profile of a set of CCPRCC using microarray and quantitative reverse transcription-polymerase chain reaction. A total of 15 cases diagnosed as CCPRCC were used in this study. Among the most differentially expressed miRNA in CCPRCC, we found miR-210, miR-122, miR-34a, miR-21, miR-34b*, and miR-489 to be up-regulated, whereas miR-4284, miR-1202, miR-135a, miR-1973, and miR-204 were down-regulated compared with normal renal parenchyma. To identify consensus of differentially regulated miRNA between CCPRCC, CCRCC, and PRCC, we additionally determined differential miRNA expression using 2 publically available microarray data sets from the NCBI Gene Expression Omnibus database (GSE41282 and GSE3798). This comparison revealed that the miRNA expression profile of CCPRCC shows some overlapping characteristics between CCRCC and PRCC. Moreover, CCPRCC lacks dysregulation of important miRNAs typically associated with aggressive behavior. In summary, we describe the miRNA expression profile of a relatively infrequent type of renal cancer. Our results may help in understanding the molecular underpinning of this newly recognized entity.

  12. Validation of the histologic grading for ovarian clear cell adenocarcinoma: a retrospective multi-institutional study by the Japan Clear Cell Carcinoma Study Group.

    Science.gov (United States)

    Yamamoto, Sohei; Kasajima, Atsuko; Takano, Masashi; Yaegashi, Nobuo; Fujiwara, Hiroyuki; Kuzuya, Kazuo; Kigawa, Junzo; Tsuda, Hiroshi; Kurachi, Hirohisa; Kikuchi, Yoshihiro; Sugiyama, Toru; Tsuda, Hitoshi; Moriya, Takuya

    2011-03-01

    Pathologic slides from 150 patients with clear cell adenocarcinoma from the collaborating institutions were reviewed independently by 2 pathologists, and each tumor was graded histologically using the Shimizu-Silverberg and International Federation of Gynecology and Obstetrics (FIGO) grading systems. For the Shimizu-Silverberg grading system, 3 parameters-architectural pattern, nuclear pleomorphism, and mitotic activity-were assessed and scored as 1 to 3. When the summed scores of these parameters were 3 to 5, 6 to 7, and 8 to 9, grades 1, 2, and 3 were assigned, respectively. The FIGO grade was based on the ratio of glandular/papillary growth versus solid growth: grade 1, less than 5% solid tumor; grade 2, 5% to 50% solid tumor; grade 3, greater than 50% solid tumor. Interobserver agreement levels for assignment of both gradings were fair (κ=0.32 and 0.24, respectively). After consensus had been acquired, 82 (55%), 56 (37%), and 12 (8%) tumors were classified as grades 1, 2, and 3 by the Shimizu-Silverberg grading system, and 88 (59%), 38 (25%), and 24 (16%) were classified as grades 1, 2, and 3 by the FIGO grading system, respectively. Survival analyses indicated that patients with grade 3 tumors, as defined by both the grading systems, tended to have a poor outcome, but any differences between them were not statistically significant. Multivariate analysis showed that only the presence of residual tumor after initial surgery was an independent prognostic factor for overall survival. These results suggest that the 2 tested grading systems have limited value for the prognostication of patients with clear cell adenocarcinoma, and that a more effective grading system for this tumor may be required.

  13. Fluorescent-protein stabilization and high-resolution imaging of cleared, intact mouse brains.

    Directory of Open Access Journals (Sweden)

    Martin K Schwarz

    Full Text Available In order to observe and quantify long-range neuronal connections in intact mouse brain by light microscopy, it is first necessary to clear the brain, thus suppressing refractive-index variations. Here we describe a method that clears the brain and preserves the signal from proteinaceous fluorophores using a pH-adjusted non-aqueous index-matching medium. Successful clearing is enabled through the use of either 1-propanol or tert-butanol during dehydration whilst maintaining a basic pH. We show that high-resolution fluorescence imaging of entire, structurally intact juvenile and adult mouse brains is possible at subcellular resolution, even following many months in clearing solution. We also show that axonal long-range projections that are EGFP-labelled by modified Rabies virus can be imaged throughout the brain using a purpose-built light-sheet fluorescence microscope. To demonstrate the viability of the technique, we determined a detailed map of the monosynaptic projections onto a target cell population in the lateral entorhinal cortex. This example demonstrates that our method permits the quantification of whole-brain connectivity patterns at the subcellular level in the uncut brain.

  14. 77 FR 38108 - Self-Regulatory Organizations; Fixed Income Clearing Corporation; Notice of Filing of Proposed...

    Science.gov (United States)

    2012-06-26

    ... illustrates the manner in which the GCF Repo service works on an interbank basis: Assume that Dealer B clears... movement in the morning. FICC shifted the service back to intrabank status to enable management to study... activity by calculating a value on the customer's balances at the bank. Bank customers have the ability...

  15. 76 FR 41056 - Amendment to Rule Filing Requirements for Dually-Registered Clearing Agencies

    Science.gov (United States)

    2011-07-13

    ..., registered clearing agency, and, for purposes of Section 19(b) and other limited purposes, the Municipal... Act, Public Law 111-203, 124 Stat. 1376 (2010). \\18\\ See Section 763(b) of the Dodd-Frank Act (adding... include the following: (i) For entities engaged in investment banking, securities dealing and...

  16. Optical clearing of melanoma in vivo: characterization by diffuse reflectance spectroscopy and optical coherence tomography

    Science.gov (United States)

    Pires, Layla; Demidov, Valentin; Vitkin, I. Alex; Bagnato, Vanderlei; Kurachi, Cristina; Wilson, Brian C.

    2016-08-01

    Melanoma is the most aggressive type of skin cancer, with significant risk of fatality. Due to its pigmentation, light-based imaging and treatment techniques are limited to near the tumor surface, which is inadequate, for example, to evaluate the microvascular density that is associated with prognosis. White-light diffuse reflectance spectroscopy (DRS) and near-infrared optical coherence tomography (OCT) were used to evaluate the effect of a topically applied optical clearing agent (OCA) in melanoma in vivo and to image the microvascular network. DRS was performed using a contact fiber optic probe in the range from 450 to 650 nm. OCT imaging was performed using a swept-source system at 1310 nm. The OCT image data were processed using speckle variance and depth-encoded algorithms. Diffuse reflectance signals decreased with clearing, dropping by ˜90% after 45 min. OCT was able to image the microvasculature in the pigmented melanoma tissue with good spatial resolution up to a depth of ˜300 μm without the use of OCA; improved contrast resolution was achieved with optical clearing to a depth of ˜750 μm in tumor. These findings are relevant to potential clinical applications in melanoma, such as assessing prognosis and treatment responses. Optical clearing may also facilitate the use of light-based treatments such as photodynamic therapy.

  17. Using Shrub Clearing, Draining, and Herbivory to Control Bramble Invasion in Mediterranean Dry Grasslands

    Science.gov (United States)

    Masson, Solène; Mesléard, François; Dutoit, Thierry

    2015-10-01

    For centuries, the dry grassland of the plain of La Crau (south-eastern France) has been subjected to numerous disturbances resulting in the destruction and the fragmentation of this emblematic rangeland ecosystem of the Mediterranean. Today, this ecosystem is facing a new threat from a proliferating native species, the bramble ( Rubus ulmifolius Schott), which preferentially colonizes areas that were formerly cultivated and/or exposed to water infiltration. To identify a strategy for effective control of this colonization, in situ experiments testing disturbance regimes (shrub clearing and/or mixed grazing by sheep and goats) combined with the control of access to water resources (with or without drainage trenches) were undertaken between 2010 and 2013. Only clearing and grazing combined over 3 years led to significant changes in vegetation height and bramble cover as well as modifications in the floristic composition, diversity, similarity, and richness of the plant community. Neither a clearing operation carried out in 2010 alone, nor grazing alone, reduced bramble cover, and neither treatment increased the species richness of the plant community. Similarly, digging drainage trenches had no significant impact either on the plant community or on bramble cover. Our study suggests that only annual mechanical clearing coupled with sheep and goats grazing can significantly reduce bramble cover. This combined restoration treatment needs to be applied for at least 3 consecutive years to induce significant changes and enable this ecosystem to return to the dry grassland succession.

  18. 75 FR 6750 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing and Immediate...

    Science.gov (United States)

    2010-02-10

    ... Securities Exchange Act of 1934,\\1\\ notice is hereby given that on January 14, 2010, The Options Clearing... proposed rule change pursuant to Section 19(b)(3)(A)(iii) of the Act \\2\\ and Rule 19b-4(f)(4) thereunder \\3... caused investor confusion because investors in some cases failed to realize that they were trading...

  19. 77 FR 47169 - Clearing Requirement Determination Under Section 2(h) of the CEA

    Science.gov (United States)

    2012-08-07

    ... Reserve Bank of New York (FRBNY) began encouraging market participants to establish a central counterparty.... \\12\\ See Federal Reserve Bank of New York, Press Release, ``New York Fed Welcomes Further Industry... Derivatives Clearinghouse Group (IDCH) on February 17, 2012; the CME Group (CME), ICE Clear Credit, ICE...

  20. 76 FR 44464 - Process for Review of Swaps for Mandatory Clearing

    Science.gov (United States)

    2011-07-26

    .... IntercontinentalExchange, Inc. (ICE) observed that the requirement that a DCO provide to the Commission a summary... a DCO to submit swaps for mandatory clearing. ICE proposed that the Commission adopt a 30-day... (Section 4s(e)(1) of the CEA) requires rules imposing capital and margin for bank swap dealers and...

  1. 75 FR 65881 - Ownership Limitations and Governance Requirements for Security-Based Swap Clearing Agencies...

    Science.gov (United States)

    2010-10-26

    ... structures relating to ownership, voting, and governance of security- based swap clearing agencies, SB SEFs...: Comments may be submitted by any of the following methods: Electronic Comments Use the Commission's... and transparency in the financial system.\\2\\ Title VII of the Dodd-Frank Act provides the...

  2. 76 FR 35141 - Protection of Cleared Swaps Customer Contracts and Collateral; Conforming Amendments to the...

    Science.gov (United States)

    2011-06-16

    ... corrects the formatting of text and charts published in the Federal Register of June 09, 2011 (76 FR 33818), regarding Protection of Cleared Swaps Customer Contracts and Collateral; Conforming Amendments to the... Collateral; Conforming Amendments to the Commodity Broker Bankruptcy Provisions; Correction AGENCY:...

  3. 78 FR 77511 - Self-Regulatory Organizations; Fixed Income Clearing Corporation; Order Approving Proposed Rule...

    Science.gov (United States)

    2013-12-23

    ..., that the rules of a clearing agency registered with the Commission be designed to promote the prompt... FR 68496 (Nov. 14, 2013) (SR-FICC-2013-09). II. Description The purpose of this proposed rule change... historical database of reference indices. This data is necessary for determining coupon, which is used...

  4. 77 FR 50425 - Clearing Exemption for Swaps Between Certain Affiliated Entities

    Science.gov (United States)

    2012-08-21

    ... submitted in English, or if not, accompanied by an English translation. ``Inter-affiliate Clearing Exemption... Commission to exempt any transaction or class of transactions, including swaps, from certain CEA provisions... way to manage risk is often at one entity and on a portfolio level. This way all the risk for...

  5. The Effects of Opaque and Clear Pit and Fissure Sealants on Infrared Laser Fluorescence Measurements

    Science.gov (United States)

    Bahrololoomi, Z.; Khodabakhsh, M.; Khaksar, Y.

    2014-01-01

    Statement of the Problem: The purpose of placing sealants is to inhibit caries by physical closure of the pits and fissures of teeth. A device named DIAGNOdent is useful in detecting occlusal caries by employing laser fluorescence (LF). However, there are contradictory results in the influence of sealants on LF measurements. Purpose: The aim of this study is to investigate the effects of two different types of fissure sealants on LF measurements. Materials and Method: In this in vitro study, 86 extracted permanent third molars were divided randomly into two groups and clear or opaque sealant was applied on the occlusal surfaces. Two examiners performed pre- and post-seal fluorescence measurements twice with one week interval by employing DIAGNOdent device. Finally, measured values were evaluated through the statistical paired t-test by means of SPSS 17 software. Results: The mean value of LF measurements increased significantly due to the application of clear sealant (p= 0.001) while the statistical changes in this measurement was negligible after applying opaque sealant (p= 0.311). Conclusion: Clear sealants increase the LF measured values but opaque sealants cause almost no changes. Therefore, DIAGNOdent device is not reliable for detecting caries beneath the clear sealant. PMID:24883342

  6. The Effects of Opaque and Clear Pit and Fissure Sealants on Infrared Laser Fluorescence Measurements

    Directory of Open Access Journals (Sweden)

    Bahrololoomi Z.

    2013-10-01

    Full Text Available Statement of the Problem: The purpose of placing sealants is to inhibit caries by physical closure of the pits and fissures of teeth. A device named DIAGNOdent is useful in detecting occlusal caries by employing laser fluorescence (LF. However, there are contradictory results in the influence of sealants on LF measurements. Purpose: The aim of this study is to investigate the effects of two different types of fissure sealants on LF measurements. Materials and Method: In this in vitro study, 86 extracted permanent third molars were divided randomly into two groups and clear or opaque sealant was applied on the occlusal surfaces. Two examiners performed pre and post-seal fluorescence measurements twice with one week interval by employing DIAGNOdent device. Finally, measured values were evaluated through the statistical paired t-test by means of SPSS 17 software. Results: The mean value of LF measurements increased significantly due to the application of clear sealant (p= 0.001 while the statistical changes in this measurement is negligible after applying opaque sealant (p= 0.311. Conclusion: Clear sealants increase the LF measured values but opaque sealants cause almost no changes. Therefore DIAGNOdent device is not reliable for detecting caries beneath the clear sealant.

  7. 75 FR 70060 - Self-Regulatory Organizations; The Options Clearing Corporation; Order Granting Approval of a...

    Science.gov (United States)

    2010-11-16

    ... Proposed Rule Change Relating to Cash- Settled Foreign Currency Options With One-Cent Exercise Prices... that cash-settled foreign currency options traded on national securities exchanges will be treated and... clear that cash-settled foreign currency options traded on national securities exchanges will be...

  8. Clear-sky atmospheric radiative transfer : a model intercomparison for shortwave irradiances

    NARCIS (Netherlands)

    Wang, P.; Knap, W.H.; Kuipers Munneke, P.; Stammes, P.

    2008-01-01

    This study consists of an intercomparison of clear-sky shortwave irradiances calculated by the Doubling Adding model of KNMI (DAK) and the Simple Model of the Atmospheric Radiative Transfer of Sunshine (SMARTS). The DAK and SMARTS models are run with identical input (state profiles, water vapour, oz

  9. Clear-sky radiative closure for the Cabauw Baseline Surface Radiation Network site, the Netherlands

    NARCIS (Netherlands)

    Wang, P.; Knap, W.H.; Kuipers Munneke, P.; Stammes, P.

    2009-01-01

    In this paper a clear-sky shortwave closure analysis is presented for the Baseline Surface Radiation Network (BSRN) site of Cabauw, Netherlands (51.97°N, 4.93°E). The analysis is based on an exceptional period of fine weather during the first half of May 2008, resulting in a selection of 72 comparis

  10. MUTATIONS IN THE VHL GENE FRIOM POTASSIUM BROMATE-INDUCED RAT CLEAR CELL RENAL TUMORS

    Science.gov (United States)

    Potassium bromate (KBrO3) is a rat renal carcinogen and a major drinking water disinfection by-product in water disinfected with ozone. Clear cell renal tumors, the most common form of human renal epithelial neoplasm, are rare in animals but are inducible by KBrO3 in F344 rats. ...

  11. 78 FR 62719 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing of Advance...

    Science.gov (United States)

    2013-10-22

    ... as a systemically important financial market utility by the Financial Stability Oversight Council on July 18, 2012. See Financial Stability Oversight Council 2012 Annual Report, Appendix A, http://www...(n)(1)(i). I. Clearing Agency's Statement of the Terms of Substance of the Advance Notice...

  12. Do zooplankton contribute to an ultraviolet clear-water phase in lakes?

    NARCIS (Netherlands)

    Williamson, C.E.; Lange, de H.J.; Leech, D.M.

    2007-01-01

    Seasonal increases in the ultraviolet (UV) transparency of the surface waters of an oligotrophic lake in Pennsylvania suggest that clear-water phase (CWP) events similar to those previously observed for visible light also exist for the potentially damaging UV wavelengths. Seasonal increases in zoopl

  13. 78 FR 21487 - Self-Regulatory Organizations; National Securities Clearing Corporation; Notice of Filing of...

    Science.gov (United States)

    2013-04-10

    ... Proposed Rule Change To Institute Supplemental Liquidity Deposits to Its Clearing Fund Designed To Increase Liquidity Resources To Meet Its Liquidity Needs April 4, 2013. Pursuant to Section 19(b)(1) of the... Change To enhance its ability to meet its liquidity requirements, NSCC is proposing to amend its...

  14. 46 CFR 308.551 - War risk insurance clearing agency agreement for cargo, Form MA-321.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false War risk insurance clearing agency agreement for cargo... EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iv-General § 308.551 War risk insurance... American War Risk Agency or MARAD....

  15. Children's Perception of Conversational and Clear American-English Vowels in Noise

    Science.gov (United States)

    Leone, Dorothy; Levy, Erika S.

    2015-01-01

    Purpose: Much of a child's day is spent listening to speech in the presence of background noise. Although accurate vowel perception is important for listeners' accurate speech perception and comprehension, little is known about children's vowel perception in noise. "Clear speech" is a speech style frequently used by talkers in the…

  16. 77 FR 27529 - Self-Regulatory Organizations; ICE Clear Credit LLC; Order Granting Accelerated Approval of...

    Science.gov (United States)

    2012-05-10

    ... promote compliance with the capital adequacy requirements, Rule 201(b)(i) is amended to provide that a Clearing Participant must be regulated for capital adequacy by a competent authority such as the CFTC, SEC... entity that satisfies the capital adequacy regulatory requirement and is subject to consolidated...

  17. Final Report on the Mississippi Project CLEAR Voice Teacher Working Conditions Survey

    Science.gov (United States)

    Berry, Barnett; Fuller, Ed

    2008-01-01

    In 2007, the state of Mississippi conducted a web-based survey of all school-based licensed educators in which they were asked to share their perceptions of the state of teacher working conditions in Mississippi. This report of the Mississippi Teacher Working Conditions Survey, Project CLEAR Voice (Cultivate Learning Environments to Accelerate…

  18. 78 FR 9751 - Self-Regulatory Organizations; National Securities Clearing Corporation; Notice of Designation of...

    Science.gov (United States)

    2013-02-11

    ... a Longer Period for Commission Action on Proposed Rule Change To Eliminate the Offset of Its... U.S.C. 78s(b)(2). The proposed rule change would permit NSCC to eliminate the offset of NSCC... Purpose of Calculating Its Clearing Fund Under Procedure XV of Its Rules & Procedures February 5, 2013....

  19. Super-resolution stimulated emission depletion imaging of slit diaphragm proteins in optically cleared kidney tissue.

    Science.gov (United States)

    Unnersjö-Jess, David; Scott, Lena; Blom, Hans; Brismar, Hjalmar

    2016-01-01

    The glomerular filtration barrier, consisting of podocyte foot processes with bridging slit diaphragm, glomerular basement membrane, and endothelium, is a key component for renal function. Previously, the subtlest elements of the filtration barrier have only been visualized using electron microscopy. However, electron microscopy is mostly restricted to ultrathin two-dimensional samples, and the possibility to simultaneously visualize multiple different proteins is limited. Therefore, we sought to implement a super-resolution immunofluorescence microscopy protocol for the study of the filtration barrier in the kidney. Recently, several optical clearing methods have been developed making it possible to image through large volumes of tissue and even whole organs using light microscopy. Here we found that hydrogel-based optical clearing is a beneficial tool to study intact renal tissue at the nanometer scale. When imaging samples using super-resolution STED microscopy, the staining quality was critical in order to assess correct nanoscale information. The signal-to-noise ratio and immunosignal homogeneity were both improved in optically cleared tissue. Thus, STED of slit diaphragms in fluorescently labeled, optically cleared, intact kidney samples is a new tool for studying the glomerular filtration barrier in health and disease.

  20. 75 FR 80335 - Federal Government Participation in the Automated Clearing House

    Science.gov (United States)

    2010-12-22

    ... House AGENCY: Financial Management Service, Fiscal Service, Treasury. ACTION: Interim final rule... governing the use of the Automated Clearing House (ACH) system by Federal agencies to permit the delivery of... institutions, consumer advocacy groups, industry associations, the Senate Committee on Finance and the...

  1. 76 FR 59024 - Federal Government Participation in the Automated Clearing House

    Science.gov (United States)

    2011-09-23

    ... House AGENCY: Financial Management Service, Fiscal Service, Treasury. ACTION: Final rule. SUMMARY: The... regulation governing the use of the Automated Clearing House (ACH) network by Federal agencies. The rule..., industry associations, the Senate Committee on Finance, and the House Committee on Ways and...

  2. 76 FR 13101 - Requirements for Processing, Clearing, and Transfer of Customer Positions

    Science.gov (United States)

    2011-03-10

    ... in English, or if not, accompanied by an English translation. Comments will be posted as received to.... an error has been made in the clearing of a trade and the error is discovered and the transfer is... approval of OMB under the PRA. \\53\\ 44 U.S.C. 3501 et seq. C. Cost-Benefit Analysis Section 15(a) of...

  3. 78 FR 28936 - Self-Regulatory Organizations; National Securities Clearing Corporation; Notice of Filing and No...

    Science.gov (United States)

    2013-05-16

    ... Change As part of its liquidity risk management regime, NSCC maintains a 364-day committed, revolving... non-defaulting Members. Any borrowing would be secured principally by (i) securities deposited by... defaulting Member upon payment of its net settlement obligation. NSCC's Clearing Fund, which operates as...

  4. Primary clear cell ductal adenocarcinoma of the pancreas: A case report and clinicopathologic literature review

    Directory of Open Access Journals (Sweden)

    Yashpal Modi

    2014-01-01

    Full Text Available We present a very rare, interesting case of a carcinoma of the pancreas with predominantly abundant clear cell morphology. According to the WHO classification, primary clear cell carcinoma of the pancreas is classified as a rare "miscellaneous" carcinoma. The tumor was observed in the distal body and tail of the pancreas of a 74-year-old woman. The histopathology of tumor cells showed well-defined cell membranes, clear cytoplasm, and prominent cell boundaries. Immunohistochemical (IHC staining showed positive reactions to antibodies against vimentin, cytokeratin 7 (CK-7, mucicarmine (MUC-1, periodic acid-Schiff (PAS, periodic acid-Schiff with diastase (PASD, carcinoembryonic antigen (CEA, and Carbohydrate Antigen 19-9 (CA 19-9. On the other hand, IHC staining was negative for alpha-fetoprotein (AFP, cytokeratin 20 (CK-20, HMB45, chromogranin, and synaptophysin. The patient was subsequently diagnosed with a primary solid-type pancreatic clear cell carcinoma with hepatic metastasis. Herein, we report this rare case and include a review of the current literature of this tumor.

  5. 78 FR 52285 - Clearing Exemption for Certain Swaps Entered Into by Cooperatives

    Science.gov (United States)

    2013-08-22

    ... for Certain Swaps Entered Into by Cooperatives; Harmonization of Compliance Obligations for Registered... COMMISSION 17 CFR Part 50 RIN 3038-AD47 Clearing Exemption for Certain Swaps Entered Into by Cooperatives... 4(c) of the Commodity Exchange Act (``CEA'') allowing cooperatives meeting certain conditions...

  6. Mortality in patients with chronic and cleared hepatitis C viral infection: a nationwide cohort study

    DEFF Research Database (Denmark)

    Omland, Lars Haukali; Krarup, Henrik; Jepsen, Peter;

    2010-01-01

    It is unknown whether mortality differs between patients with chronic hepatitis C virus (HCV) replication and those who cleared the virus after infection. We examined the impact of chronic HCV replication on mortality among Danish patients testing positive for HCV antibodies....

  7. Clear Cell Carcinoma of the Breast: A Rare Breast Cancer Subtype - Case Report and Literature Review

    Directory of Open Access Journals (Sweden)

    Vilma Ratti

    2015-11-01

    Full Text Available Background: Glycogen-rich clear cell breast carcinoma is a rare histological breast cancer subtype. Its prognosis may vary depending on specific clinical and pathological characteristics such as low grade, strong positivity of estrogen receptor (ER expression and early diagnosis. Case Presentation: We present the case of a 53-year-old woman with a bleeding 10-cm-diameter mass in the left breast. The histological examination showed a poorly differentiated tumor with malignant cells characterized by abundant clear cytoplasm. The diagnosis of clear cell carcinoma was based on the histological characteristics of the tumor, and a nonmammary origin was initially ruled out. The tumor was triple negative [i.e. ER, progesterone receptor (PR and HER2 negative]. Four months after the initial locoregional treatment, the patient developed lung and distant lymph node metastases. Conclusions: Glycogen-rich clear cell carcinoma of the breast is a rare tumor. Early diagnosis, absence of lymph node metastases and ER/PR positivity are associated with a better prognosis, as in other common breast cancer subtypes.

  8. 77 FR 77157 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing and Immediate...

    Science.gov (United States)

    2012-12-31

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Amend Interpretative Guidance Relating to the Adjustment of Stock Options and Single Stock Futures...

  9. Mortality among patients with cleared hepatitis C virus infection compared to the general population

    DEFF Research Database (Denmark)

    Omland, Lars Haukali; Christensen, Peer Brehm; Krarup, Henrik Bygum;

    2011-01-01

    The increased mortality in HCV-infected individuals partly stems from viral damage to the liver and partly from risk-taking behaviours. We examined mortality in patients who cleared their HCV-infection, comparing it to that of the general population. We also addressed the question whether prognos...... differed according to age, substance abuse (alcohol abuse and injection drug use) and comorbidity....

  10. 77 FR 71466 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing of Proposed...

    Science.gov (United States)

    2012-11-30

    ... Terms of Substance of the Proposed Rule Change OCC proposes to make certain changes to Rule 1104 in... separation of firm and customer positions), clearing members have discretion as to which Stock Loan Positions... submitted by any of the following methods: Electronic Comments Use the Commissions Internet comment...

  11. 76 FR 69333 - Derivatives Clearing Organization General Provisions and Core Principles

    Science.gov (United States)

    2011-11-08

    ... Clearing Organization General Provisions and Core Principles; Final Rule #0;#0;Federal Register / Vol. 76... and Core Principles AGENCY: Commodity Futures Trading Commission. ACTION: Final rule. SUMMARY: The... regulations establish the regulatory standards for compliance with DCO Core Principles A (Compliance),...

  12. A case report of the clear cell variant of gallbladder carcinoma

    Directory of Open Access Journals (Sweden)

    Ravi Maharaj

    2017-01-01

    Conclusion: In these cases, clinical case management should be personalized for increased survival with the possible incorporation of next generation sequencing approaches to guide therapeutic algorithms. We discuss this exceedingly rare case of the clear cell variant of gallbladder carcinoma in detail, highlighting some of the diagnostic, and clinical challenges.

  13. 78 FR 76182 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing of Proposed...

    Science.gov (United States)

    2013-12-16

    ... review the overall corporate governance of OCC and recommend improvements to OCC's Board. The GC Charter... Change Concerning the Governance Committee Charter December 11, 2013. Pursuant to Section 19(b)(1) of the... Options Clearing Corporation (``OCC'') concerns the charter of the Governance Committee (``GC...

  14. 76 FR 77287 - Self-Regulatory Organizations; Fixed Income Clearing Corporation; Notice of Filing of Proposed...

    Science.gov (United States)

    2011-12-12

    ... MBSD rules will have a revised Rule 1, ``Definitions,'' which will include terminology applicable to....) or non-compliance with MBSD rules. The Clearing Fund is calculated every business day for each MBSD... interest, established by the Corporation on each business day, based on current market information for...

  15. 78 FR 42809 - Self-Regulatory Organizations; Fixed Income Clearing Corporation; Order Approving Proposed Rule...

    Science.gov (United States)

    2013-07-17

    ... Futures Trading Commission.\\8\\ The swap transactions executed by trueEX are cleared by a clearinghouse..., notes, bonds, Treasury inflation-protected securities (TIPS) and separate trading of registered interest..., including testing trueEX's trade input and receipt of output capabilities prior to the go-live date....

  16. 78 FR 75413 - Self-Regulatory Organizations; National Securities Clearing Corporation; Order Approving Proposed...

    Science.gov (United States)

    2013-12-11

    ... received.\\24\\ The Commission has reviewed and taken into full consideration all of the comments received... obligation and thus are relevant for the Commission's consideration of the Final SLD Proposal.\\41\\ Four... requires that: the rules of a clearing agency not be designed to permit unfair discrimination...

  17. High-resolution in-depth imaging of optically cleared thick samples using an adaptive SPIM

    Science.gov (United States)

    Masson, Aurore; Escande, Paul; Frongia, Céline; Clouvel, Grégory; Ducommun, Bernard; Lorenzo, Corinne

    2015-11-01

    Today, Light Sheet Fluorescence Microscopy (LSFM) makes it possible to image fluorescent samples through depths of several hundreds of microns. However, LSFM also suffers from scattering, absorption and optical aberrations. Spatial variations in the refractive index inside the samples cause major changes to the light path resulting in loss of signal and contrast in the deepest regions, thus impairing in-depth imaging capability. These effects are particularly marked when inhomogeneous, complex biological samples are under study. Recently, chemical treatments have been developed to render a sample transparent by homogenizing its refractive index (RI), consequently enabling a reduction of scattering phenomena and a simplification of optical aberration patterns. One drawback of these methods is that the resulting RI of cleared samples does not match the working RI medium generally used for LSFM lenses. This RI mismatch leads to the presence of low-order aberrations and therefore to a significant degradation of image quality. In this paper, we introduce an original optical-chemical combined method based on an adaptive SPIM and a water-based clearing protocol enabling compensation for aberrations arising from RI mismatches induced by optical clearing methods and acquisition of high-resolution in-depth images of optically cleared complex thick samples such as Multi-Cellular Tumour Spheroids.

  18. 76 FR 722 - Governance Requirements for Derivatives Clearing Organizations, Designated Contract Markets, and...

    Science.gov (United States)

    2011-01-06

    ... COMMISSION 17 CFR Parts 1, 37, 38, 39, and 40 RIN 3038-AD01 Governance Requirements for Derivatives Clearing... concerning governance fitness standards and the composition of governing bodies. Finally, for publicly-traded... conflicts, the Commission proposed \\6\\ both (i) structural governance requirements \\7\\ and (ii) limits...

  19. Seasonal distribution, aggregation, and habitat selection of common carp in Clear Lake, Iowa

    Science.gov (United States)

    Penne, C.R.; Pierce, C.L.

    2008-01-01

    The common carp Cyprinus carpio is widely distributed and frequently considered a nuisance species outside its native range. Common carp are abundant in Clear Lake, Iowa, where their presence is both a symptom of degradation and an impediment to improving water quality and the sport fishery. We used radiotelemetry to quantify seasonal distribution, aggregation, and habitat selection of adult and subadult common carp in Clear Lake during 2005-2006 in an effort to guide future control strategies. Over a 22-month period, we recorded 1,951 locations of 54 adults and 60 subadults implanted with radio transmitters. Adults demonstrated a clear tendency to aggregate in an offshore area during the late fall and winter and in shallow, vegetated areas before and during spring spawning. Late-fall and winter aggregations were estimated to include a larger percentage of the tracked adults than spring aggregations. Subadults aggregated in shallow, vegetated areas during the spring and early summer. Our study, when considered in combination with previous research, suggests repeatable patterns of distribution, aggregation, and habitat selection that should facilitate common carp reduction programs in Clear Lake and similar systems. ?? Copyright by the American Fisheries Society 2008.

  20. 77 FR 58194 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing of Proposed...

    Science.gov (United States)

    2012-09-19

    ..., through cross-references to interpretive provisions of OCC Rule 306--Financial Reports and OCC Rule 308... reporting of certain financial liabilities to U.S. Generally Accepted Accounting Principles. Canadian... Change Relating to Financial Reporting by Canadian Clearing Members September 13, 2012. Pursuant...

  1. Clear Cells of Toker in the Developing Anogenital Region of Male and Female Fetuses

    NARCIS (Netherlands)

    van der Putte, Sebastian C. J.

    2011-01-01

    The clear cells of Toker are a mysterious population of intra-epidermal glandular cells. They were originally described in nipples, but were recently observed in the vulva as well. It was hypothesized that intra-epidermal embryonic remnants or underlying glands were a potential source. The embryolog

  2. Clearing lakes. An ecosystem approach to the restoration and management of shallow lakes in the Netherlands.

    NARCIS (Netherlands)

    Hosper, H.

    1997-01-01

    In the 1950 s and 1960 s, most shallow lakes in the Netherlands shifted from macrophyte-dominated clear water lakes, towards algae-dominated turbid water lakes. Eutrophication, i.e. increased nutrient loading, is the main cause of the deterioration of the lake ecosystems. Other perturbations, such a

  3. 76 FR 38225 - Self-Regulatory Organizations; The Options Clearing Corporation; Order Approving Proposed Rule...

    Science.gov (United States)

    2011-06-29

    ... by 10 a.m. constitutes a default. During discussions among OCC's senior management of various potential extreme default and liquidity squeeze scenarios, including the possible default of one of OCC's largest clearing members, OCC analyzed the risk associated with not being able to immediately...

  4. 77 FR 66196 - Self-Regulatory Organizations; Options Clearing Corporation; Order Approving Proposed Rule Change...

    Science.gov (United States)

    2012-11-02

    ... JRFQR with ``Form 1'' of the International Financial Reporting Standards. OCC proposes to replace... Financial Reporting Standards. OCC Rule 310, through cross-references to interpretive provisions of OCC Rule... Relating to Financial Reporting by Canadian Clearing Members October 26, 2012. I. Introduction On...

  5. Approach to In Situ Component Level Electronics Assembly Repair (CLEAR) for Constellation

    Science.gov (United States)

    Struk, Peter M.; Oeftering, Richard C.

    2010-01-01

    Maintenance resupply is a significant issue for long duration space missions. Currently, the International Space Station (ISS) approaches maintenance primarily around replaceable modules called Orbital Replacement Units (ORU). While swapping out ORUs has served the ISS well keeping crew time for maintenance to a minimum, this approach assumes a substantial logistics capacity to provide replacement ORUs and return ORUs to Earth for repair. The ORUs used for ISS require relatively large blocks of replacement hardware even though the actual failed component may be several orders of magnitude smaller. The Component Level Electronics Assembly Repair (CLEAR) task was created to explore electronics repair down to the component level for future space missions. From 2006 to 2009, CLEAR was an activity under the Supportability project of the Exploration Technology Development Program. This paper describes the activities of CLEAR including making a case for component-level electronics repair, examination of current terrestrial repair hardware, and potential repair needs. Based on those needs, the CLEAR team proposes an architecture for an in-situ repair capability aboard a spacecraft or habitat. Additionally, this paper discusses recent progress toward developing in-space repair capabilities--including two spaceflight experiments-- and presents technology concepts which could help enable or benefit the same.

  6. Sediment properties and CO2 efflux from intact and cleared temperate mangrove forests

    Science.gov (United States)

    Bulmer, R. H.; Lundquist, C. J.; Schwendenmann, L.

    2015-10-01

    Temperate mangrove forests in New Zealand have increased in area over recent decades. Expansion of temperate mangroves in New Zealand is associated with perceived loss of other estuarine habitats, and decreased recreational and amenity values, resulting in clearing of mangrove forests. In the tropics, changes in sediment characteristics and carbon efflux have been reported following mangrove clearance. This is the first study in temperate mangrove (Avicennia marina) forests investigating the impact of clearing on sediment CO2 efflux and associated biotic and abiotic factors. Sediment CO2 efflux rates from intact (168.5 ± 45.8 mmol m-2 d-1) and cleared (133.9 ± 37.2 mmol m-2 d-1) mangrove forests in New Zealand are comparable to rates measured in tropical mangrove forests. We did not find a significant difference in sediment CO2 efflux rates between intact and cleared temperate mangrove forests. Pre-shading the sediment for more than 30 min prior to dark chamber measurements was found to have no significant effect on sediment CO2 efflux. This suggests that the continuation of photosynthetic CO2 uptake by biofilm communities was not occurring after placement of dark chambers. Rather, above-ground mangrove biomass, sediment temperature and chlorophyll a concentration were the main factors explaining the variability in sediment CO2 efflux in intact mangrove forests. The main factors influencing sediment CO2 efflux in cleared mangrove forest sites were sediment organic carbon concentration, nitrogen concentration and sediment grain size. Our results show that greater consideration should be given regarding the rate of carbon released from mangrove forest following clearance and the relative contribution to global carbon emissions.

  7. A Supplementary Clear-Sky Snow and Ice Recognition Technique for CERES Level 2 Products

    Science.gov (United States)

    Radkevich, Alexander; Khlopenkov, Konstantin; Rutan, David; Kato, Seiji

    2013-01-01

    Identification of clear-sky snow and ice is an important step in the production of cryosphere radiation budget products, which are used in the derivation of long-term data series for climate research. In this paper, a new method of clear-sky snow/ice identification for Moderate Resolution Imaging Spectroradiometer (MODIS) is presented. The algorithm's goal is to enhance the identification of snow and ice within the Clouds and the Earth's Radiant Energy System (CERES) data after application of the standard CERES scene identification scheme. The input of the algorithm uses spectral radiances from five MODIS bands and surface skin temperature available in the CERES Single Scanner Footprint (SSF) product. The algorithm produces a cryosphere rating from an aggregated test: a higher rating corresponds to a more certain identification of the clear-sky snow/ice-covered scene. Empirical analysis of regions of interest representing distinctive targets such as snow, ice, ice and water clouds, open waters, and snow-free land selected from a number of MODIS images shows that the cryosphere rating of snow/ice targets falls into 95% confidence intervals lying above the same confidence intervals of all other targets. This enables recognition of clear-sky cryosphere by using a single threshold applied to the rating, which makes this technique different from traditional branching techniques based on multiple thresholds. Limited tests show that the established threshold clearly separates the cryosphere rating values computed for the cryosphere from those computed for noncryosphere scenes, whereas individual tests applied consequently cannot reliably identify the cryosphere for complex scenes.

  8. A pilot study comparing opaque, weighted bottles with conventional, clear bottles for infant feeding.

    Science.gov (United States)

    Ventura, Alison K; Pollack Golen, Rebecca

    2015-02-01

    It is hypothesized that the visual and weight cues afforded by bottle-feeding may lead mothers to overfeed in response to the amount of liquid in the bottle. The aim of the present pilot study was to test this hypothesis by comparing mothers' sensitivity and responsiveness to infant cues and infants' intakes when mothers use opaque, weighted bottles (that remove visual and weight cues) compared to conventional, clear bottles to feed their infants. We also tested the hypothesis that mothers' pressuring feeding style would moderate the effect of bottle type. Formula-feeding dyads (N = 25) visited our laboratory on two separate days. Mothers fed their infants from a clear bottle one day and an opaque, weighted bottle on the other; bottle-order was counterbalanced across the two days. Infant intake was assessed by weighing each bottle before and after the feeding. Maternal sensitivity and responsiveness to infant cues was objectively assessed using the Nursing Child Assessment Feeding Scale. Mothers were significantly more responsive to infant cues when they used opaque compared to clear bottles (p = .04). There was also a trend for infants to consume significantly less formula when fed from opaque compared to clear bottles (p = .08). Mothers' pressuring feeding style moderated the effect of bottle type on maternal responsiveness to infant cues (p = .02) and infant intake (p = .03). Specifically, mothers who reported higher levels of pressuring feeding were significantly more responsive to their infants' cues (p = .02) and fed their infants significantly less formula when using opaque versus clear bottles (p = .01); no differences were seen for mothers who reported lower levels of pressuring feeding. This study highlights a simple, yet effective intervention for improving the bottle-feeding practices of mothers who have pressuring feeding styles.

  9. Nitrification and nitrifying bacterial communities in coniferous forest soils. Effects of liming and clear-cutting

    Energy Technology Data Exchange (ETDEWEB)

    Baeckman, Jenny

    2003-05-01

    This thesis deals with the effects of liming and clear-cutting on nitrification in hemi-boreal and northern temperate coniferous forest soils. The approach has been to study both the potential nitrification and the community structure of the ammonia-oxidising bacteria, which carry out the first step of autotrophic nitrification. The potential nitrification was measured over short time incubations at optimal conditions for acid-sensitive, autotrophic nitrification. This method yields the potential nitrification of the actual nitrifying community. I studied the autotrophic ammonia-oxidising community at gene level (16S rRNA gene) using molecular methods, such as polymerase chain reaction (PCR), denaturing gradient gel electrophoresis (DGGE), single-strand conformation polymorphism (SSCP), and DNA sequencing. The results illustrate that both liming and clear-cutting may increase the potential nitrification by stimulating the growth of ammonia-oxidisers. Both these forest practises seem to favour the growth of Nitrosospira cluster 4-affiliated ammonia-oxidisers, although Nitrosospira cluster 2-affiliated bacteria also was present. The stimulated growth of the ammonia-oxidisers is caused by increased ammonia availability and more favourable pH (i.e. higher and more stable pH over time). The results also show that clear-cutting causes more intense growth of the ammonia-oxidisers and thereby larger potential nitrification than liming does. When forests that have previously been limed are clear-cut, nitrification responses more rapidly and the rates are larger compared to non-limed forests, since the ammonia-oxidising communities in limed soils seem better adapted to the conditions after the cutting. Liming does, however, not always increase nitrification. Although it may increase nitrogen mineralisation, it seems like the nitrogen status of the soil prior to liming is the most important factor, since liming caused the greatest response in potential nitrification in areas

  10. Evolution of the landscape along the Clear Creek Corridor, Colorado; urbanization, aggregate mining and reclamation

    Science.gov (United States)

    Arbogast, Belinda; Knepper, Daniel H.; Melick, Roger A.; Hickman, John

    2002-01-01

    Prime agricultural land along the Clear Creek floodplain, Colorado, attracted settlement in the 1850's but the demand for sand and gravel for 1900's construction initiated a sequence of events that exceeded previous interests and created the modified landscape and urban ecosystem that exists today. The Clear Creek valley corridor offers a landscape filled with a persistent visible and hidden reminder of it's past use. The map sheets illustrate the Clear Creek landscape as a series of compositions, both at the macro view (in the spatial context of urban structure and highways from aerial photographs) and micro view (from the civic scale where landscape features like trees, buildings, and sidewalks are included). The large-scale topographic features, such as mountains and terraces, appear 'changeless' (they do change over geologic time), while Clear Creek has changed from a wide braided stream to a narrow confined stream. Transportation networks (streets and highways) and spiraling population growth in adjacent cities (from approximately 38,000 people in 1880 to over a million in 1999) form two dominant landscape patterns. Mining and wetland/riparian occupy the smallest amount of land use acres compared to urban, transportation, or water reservoir activities in the Clear Creek aggregate reserve study area. Four types of reclaimed pits along Clear Creek were determined: water storage facilities, wildlife/greenbelt space, multiple-purpose reservoirs, and 'hidden scenery.' The latter involves infilling gravel pits (with earth backfill, concrete rubble, or sanitary landfill) and covering the site with light industry or residential housing making the landform hard to detect as a past mine site. Easier to recognize are the strong-edged, rectilinear water reservoirs, reclaimed from off-channel sand and gravel pits that reflect the land survey grid and property boundaries. The general public may not realize softly contoured linear wildlife corridors connecting urban

  11. A Study of Global Cirrus Cloud Morphology with AIRS Cloud-clear Radiances (CCRs)

    Science.gov (United States)

    Wu, Dong L.; Gong, Jie

    2012-01-01

    Version 6 (V6) AIRS cloud-clear radiances (CCR) are used to derive cloud-induced radiance (Tcir=Tb-CCR) at the infrared frequencies of weighting functions peaked in the middle troposphere. The significantly improved V 6 CCR product allows a more accurate estimation of the expected clear-sky radiance as if clouds are absent. In the case where strong cloud scattering is present, the CCR becomes unreliable, which is reflected by its estimated uncertainty, and interpolation is employed to replace this CCR value. We find that Tcir derived from this CCR method are much better than other methods and detect more clouds in the upper and lower troposphere as well as in the polar regions where cloud detection is particularly challenging. The cloud morphology derived from the V6 test month, as well as some artifacts, will be shown.

  12. Global solar irradiance in Cordoba: Clearness index distributions conditioned to the optical air mass

    Energy Technology Data Exchange (ETDEWEB)

    Varo, M.; Pedros, G.; Martinez-Jimenez, P. [Applied Physics Department, EPS, University of Cordoba, C/Maria Virgen y Madre s/n., Cordoba 14004 (Spain); Aguilera, M.J. [Applied Physics Department, ETSIAM, University of Cordoba, C/Menendez Pidal, s/n., Cordoba, 14004 (Spain)

    2006-07-15

    The biological and photochemical effects of solar radiation and solar energy applications make it really important to characterize the variability of this component. In view of the fact that the clearness index indicates not only the level of availability of solar radiation but also the changes in atmospheric conditions in a given location, since the classic Liu and Jordan study, many papers have dealt with its statistical distribution. Specifically, Tovar et al. [Tovar J, Olmo FJ, Alados-Arboledas L. Solar Energy 1998;62(6):387-393] proposed a model to represent the probability density distributions of the instantaneous clearness index conditioned to the optical air mass from measurements recorded in Granada (Spain). In this work, we have proved the applicability of this model in a different location, Cordoba (Spain), finding that the parameters for fitting the model depend on both the optical air mass and the geographic and climatic conditions. (author)

  13. Effects of clear topical ointment on transepidermal water loss in jaundiced pretermm infants receiving phototherapy.

    Science.gov (United States)

    Wananukul, S; Praisuwanna, P; Kesorncam, K

    2001-06-01

    Thirty jaundiced preterm infants, gestational age incubators were included. 1.5 ml of clear topical ointment was applied on the right side of the trunk and extremities while the left side was used as control. Data collection included transepidermal water loss (TEWL), ambient temperature and ambient humidity, before and at 30 minutes, 4-6 hours after application of the ointment during phototherapy. The measurements were executed both the right and left side in 3 positions; upper arm, back, lower leg. TEWL was reduced by 29 per cent (P value humidity were not significantly different (P value > 0.18). We concluded that application of clear topical ointment on the skin of jaundiced preterm infants receiving conventional phototherapy in incubators reduced TEWL significantly.

  14. Modifying the Balanced Scorecard for a Network Industry The Case of the Clearing Industry

    Science.gov (United States)

    Chlistalla, Michael; Schaper, Torsten

    The Balanced Scorecard (BSC) is a well-established framework for the management of a company as it integrates financial and non-financial perspectives. Little attention has been given to its theoretical and conceptual valuation. We illustrate how the stakeholder value theory corresponds with the concept of the BSC and show the importance of underlying cause-and-effect relationships between its perspectives. For the case of clearing in Europe which is currently facing profound changes, we present our three-phased approach how to adjust and to extend Kaplan and Norton’s original concept. We modify the generic BSC by adding risk management as a separate perspective and by integrating competition and IT. Based on multiple case studies, we then validate whether the modified BSC is suited to meet the specifics of the clearing industry.

  15. Primary Clear Cell Adenocarcinoma of a Urethral Diverticulum Treated with Multidisciplinary Robotic Anterior Pelvic Exenteration

    Directory of Open Access Journals (Sweden)

    Dane Scantling

    2013-01-01

    Full Text Available Primary urethral carcinoma is extremely rare and is marked by a variety of clinical symptoms. Primary carcinoma of a urethral diverticulum is still rarer and clear cell adenocarcinoma of the urethra is particularly uncommon (Swartz et al., 2006. Such infrequency has led to inadequate management guidance in the literature for a disease that is often late in presentation and carries substantial morbidity and mortality. This treatable but grave disease deserves definitive curative treatment. We present the first published instance in which it was treated with robotic anterior exenteration. In our case, a 47-year-old female was referred to the urology service for investigation of recurring urinary tract infections. During the workup, the patient was found to have an advanced clear cell urethral adenocarcinoma originating in a urethral diverticulum. We discuss the natural history of this condition, its consequences, and the first instance of its treatment using robotic anterior pelvic exenteration.

  16. Clear cell myoepithelioma of palate with emphasis on clinical and histological differential diagnosis.

    Science.gov (United States)

    Nair, Bindu J; Vivek, Velayudhannair; Sivakumar, Trivandrum T; Joseph, Anna P; Varun, Babyamma Raghavanpillai; Mony, Vinod

    2014-03-27

    Myoepitheliomas account for less than 1% of all salivary gland tumors and mostly occur in the parotid gland and palate. A 58-year old male patient reported to the Outpatient Department of PMS College of Dental Science and Research (Kerala, India) with a slow growing painless swelling on the palate for 4 years. Pleomorphic adenoma, basal cell adenoma, myoepithelioma, cyst adenoma, lipoma, neurofibroma, neurilemmoma and leiomyoma were considered. Histopathology revealed a thinly encapsulated tumor composed mainly of sheets of clear cells mixed with cells having eosinophilic cytoplasm. Histopathological differential diagnosis included pleomorphic adenoma, oncocytoma, oncocytic hyperplasia, sebaceous adenoma, malignant salivary gland neoplasms and metastatic lesions from kidney and thyroid. Myoepitheliomas mostly occur in the parotid gland and palatal region and various histological types of myoepithelioma are described. Myoepitheliomas of the palate are rare with clear cell variant even rarer.

  17. A comparison between radiovisiography and clearing technique in the study of the root canal types

    Institute of Scientific and Technical Information of China (English)

    Daming Wu; Younong Wu

    2005-01-01

    Objective: To compare the radiovisiography (RVG) with the clearing technique using Kappa value in the study of the root canal types. Methods: One hundred recently extracted human maxillary first premolars were used. Standard periapical RVG images were taken from a buccolingual and mesiodistal direction. The specimens were then accessed, injected with ink, demineralized,dehydrated, and finally were cleared. The RVG images and the transparent teeth were examined by a trained endodontist, and the date of root canal types following Wu's classification was collected. Results: The reliability of RVG was high for studies on simple root canals,but was poor for the studies on the multiple root canals. The Kappa value between the two techniques was 0.3793, indicating the agreement was poor. Conclusion: It is concluded that the limited value of RVG alone when studying certain aspect of the root canal system. The resolution of the RVG system should be enhanced.

  18. Production and perception of listener-oriented clear speech in child language.

    Science.gov (United States)

    Syrett, Kristen; Kawahara, Shigeto

    2014-11-01

    In this paper, we ask whether children are sensitive to the needs of their interlocutor, and, if so, whether they - like adults - modify acoustic characteristics of their speech as part of a communicative goal. In a production task, preschoolers participated in a word learning task that favored the use of clear speech. Children produced vowels that were longer, more intense, more dispersed in the vowel space, and had a more expanded F0 range than normal speech. Two perception studies with adults showed that these acoustic differences were perceptible and were used to distinguish normal and clear speech styles. We conclude that preschoolers are sensitive to aspects of the speaker-hearer relationship calling upon them to modify their speech in ways that benefit their listener.

  19. Gridded bathymetry data of Clear Creek Reservoir, Chaffee County, Colorado, 2016

    Science.gov (United States)

    Kohn, Michael S.

    2017-01-01

    To better characterize the water supply capacity of Clear Creek Reservoir, Chaffee County, Colorado, the U.S. Geological Survey, in cooperation with the Pueblo Board of Water Works and Colorado Mountain College, carried out a bathymetry survey of Clear Creek Reservoir. The bathymetry data of the reservoir is presented here in a 1-foot grid. The bathymetry survey was carried out June 6–9, 2016, using a man-operated boat-mounted, multibeam echo sounder integrated with a Global Positioning System (GPS) and a terrestrial survey using real-time kinematic (RTK) Global Navigation Satellite Systems (GNSS). The two collected datasets were merged and imported into geographic information system software. The equipment and methods used in this study allowed water-resource managers to maintain typical reservoir operations, eliminating the need to empty the reservoir to carry out the survey.

  20. Systematic Evaluation of the Prognostic Impact and Intratumour Heterogeneity of Clear Cell Renal Cell Carcinoma Biomarkers

    DEFF Research Database (Denmark)

    Gulati, Sakshi; Martinez, Pierre; Joshi, Tejal;

    2014-01-01

    BackgroundCandidate biomarkers have been identified for clear cell renal cell carcinoma (ccRCC) patients, but most have not been validated. ObjectiveTo validate published ccRCC prognostic biomarkers in an independent patient cohort and to assess intratumour heterogeneity (ITH) of the most promising...... markers to guide biomarker optimisation. Design, setting, and participantsCancer-specific survival (CSS) for each of 28 identified genetic or transcriptomic biomarkers was assessed in 350 ccRCC patients. ITH was interrogated in a multiregion biopsy data set of 10 ccRCCs. Outcome measurements...... of published biomarkers to predict the survival of patients with clear cell kidney cancer in an independent patient cohort. Only one molecular test adds prognostic information to routine clinical assessments. This marker showed good and poor prognosis results within most individual cancers. Future biomarkers...

  1. Count rate performance study of the Lausanne ClearPET scanner demonstrator

    Energy Technology Data Exchange (ETDEWEB)

    Rey, M. [LPHE, Ecole Polytechnique Federale de Lausanne, CH-1015 Lausanne (Switzerland)]. E-mail: martin.rey@epfl.ch; Jan, S. [Service Hospitalier Frederic Joliot, CEA, F-91401 Orsay (France); Vieira, J.-M. [LPHE, Ecole Polytechnique Federale de Lausanne, CH-1015 Lausanne (Switzerland); Mosset, J.-B. [LPHE, Ecole Polytechnique Federale de Lausanne, CH-1015 Lausanne (Switzerland); Krieguer, M. [IIHE, Vrije Universiteit Brussel, B-1050 Brussels (Belgium); Comtat, C. [Service Hospitalier Frederic Joliot, CEA, F-91401 Orsay (France); Morel, C. [CPPM, CNRS-IN2P3, Universite de la Mediterranee Aix-Marseille II, F-13288 Marseille (France)

    2007-02-01

    This paper presents the count rate measurements obtained with the Lausanne partial ring ClearPET scanner demonstrator and compares them against GATE Monte Carlo simulations. For the present detector setup, a maximum single event count rate of 1.1 Mcps is measured or a 250-750 keV energy window. This corresponds to a coincidence count rate of approximately 22 kcps. Good agreements are observed between measured and simulated data. Count rate performance, including Noise Equivalent Count (NEC) curves, are determined and extrapolated for a full ring ClearPET design using GATE Monte Carlo simulations. For a full ring design with three rings of detector modules, NEC is peaking at about 70 kcps for 20 MBq.

  2. Comparison of Enamel and Stainless Steel Electron Cloud Clearing Electrodes Tested in the CERN Proton Synchrotron

    CERN Document Server

    Caspers, Friedhelm; Mahner, C; Wendel, JC

    2010-01-01

    During the 2007 run with the nominal LHC proton beam, electron cloud has been clearly identified and characterized in the PS using a dedicated setup with shielded button-type pickups. Efficient electron cloud suppression could be achieved with a stainless steel stripline-type electrode biased to negative and positive voltages up to ± 1 kV. For the 2008 run, a second setup was installed in straight section 84 of the PS where the stainless steel was replaced by a stripline composed of an enamel insulator with a resistive coating. In contrast to ordinary stripline electrodes this setup presents a very low beam coupling impedance and could thus be envisaged for long sections of high-intensity machines. Here, we present first comparative measurements with this new type of enamel clearing electrode using the nominal LHC beam with 72 bunches and 25 ns bunch spacing.

  3. Clear cell variant of squamous cell carcinoma of skin: A report of a case

    Directory of Open Access Journals (Sweden)

    Ahmed Oluwatoyin Lawal

    2013-01-01

    Full Text Available Clear cell squamous cell carcinoma (SCC is a rare variant of SCC of skin in which ultraviolet radiation has been suggested as possible etiology. This case is that of a 62-year-old male concrete block maker/bricklayer who presented with a 6 months history of a non-healing ulcer on the left side of his face. Histology showed features of malignant epithelial neoplasm composed of islands of large oval to polyhedral malignant squamous cells with eosinophilic to amphophilic cytoplasm and vesicular nuclei and there were areas showing clear cell differentiation and isolated areas of keratin pearl formation. The lesion was also negative for periodic acid schiff, mucicarmine, and alcian blue stains but was strongly positive for AE1/AE3 (immuno-stain. This case showed an aggressive and bizarre clinical presentation but more report of cases are needed to have a better characterization of the clinical presentation and prognosis of this variant of SCC.

  4. Clear cell variant of squamous cell carcinoma of skin: A report of a case.

    Science.gov (United States)

    Lawal, Ahmed Oluwatoyin; Adisa, Akinyele Olumuyiwa; Olajide, Mofoluwaso A; Olusanya, Adeola Adenike

    2013-01-01

    Clear cell squamous cell carcinoma (SCC) is a rare variant of SCC of skin in which ultraviolet radiation has been suggested as possible etiology. This case is that of a 62-year-old male concrete block maker/bricklayer who presented with a 6 months history of a non-healing ulcer on the left side of his face. Histology showed features of malignant epithelial neoplasm composed of islands of large oval to polyhedral malignant squamous cells with eosinophilic to amphophilic cytoplasm and vesicular nuclei and there were areas showing clear cell differentiation and isolated areas of keratin pearl formation. The lesion was also negative for periodic acid schiff, mucicarmine, and alcian blue stains but was strongly positive for AE1/AE3 (immuno-stain). This case showed an aggressive and bizarre clinical presentation but more report of cases are needed to have a better characterization of the clinical presentation and prognosis of this variant of SCC.

  5. A Novel Method for Preparing Approximately Micron-sized Polymethyl Methacrylate Microspheres with Clear Surface

    Institute of Scientific and Technical Information of China (English)

    Di Qiang WANG; Bai Ling LIU; Jie HU; Xiao Qin LIN; Min ZHANG

    2004-01-01

    Polymethyl methacrylate (PMMA) microspheres with clear surface and diameter close to 1 μm were synthesized by newly soap-free emulsion polymerization. The results showed that the presence of ethanol and NaCl made the increase of diameter and distribution, while the presence of toluene could avoid the problem of the increase of distribution, resulting a harvest of PMMA microspheres with a diameter close to 1 μm.

  6. Ventilator versus manual hyperinflation in clearing sputum in ventilated intensive care unit patients.

    Science.gov (United States)

    Dennis, Diane; Jacob, Wendy; Budgeon, Charley

    2012-01-01

    The aim of hyperinflation in the ventilated intensive care unit patient is to increase oxygenation, reverse lung collapse and clear sputum. The efficacy and consistency of manual hyperventilation is well supported in the literature, but there is limited published evidence supporting hyperventilation utilising a ventilator. Despite this, a recent survey established that almost 40% of Australian tertiary intensive care units utilise ventilator hyperinflation. The aim of this non-inferiority cross-over study was to determine whether ventilator hyperinflation was as effective as manual hyperinflation in clearing sputum from patients receiving mechanical ventilation using a prescriptive ventilator hyperinflation protocol. Forty-six patients received two randomly ordered physiotherapy treatments on the same day by the same physiotherapist. The efficacy of the hyperinflation modes was measured by sputum wet weight. Secondary measures included compliance, tidal volume, airway pressure and PaO2/FiO2 ratio. There was no difference in wet weight of sputum cleared using ventilator hyperinflation or manual hyperinflation (mean 3.2 g, P=0.989). Further, no difference in compliance (P=0.823), tidal volume (P=0.219), heart rate (P=0.579), respiratory rate (P=0.929) or mean arterial pressure (P=0.593) was detected. A statistically significant difference was seen in mean airway pressure (P=0.002) between techniques. The effect of techniques on the PaO2/FiO2 response ratio was dependent on time (interaction P=0.024). Physiotherapy using ventilator hyperinflation cleared a comparable amount of sputum and was as safe as manual hyperinflation. This research describes a ventilator hyperinflation protocol that will serve as a platform for continued discussion, research and development of its application in ventilated patients.

  7. Using clear aligner therapy to correct malocclusion with crowding and an open bite.

    Science.gov (United States)

    Harnick, David J

    2012-01-01

    Clear aligner therapy (CAT) has been used successfully to correct minor spacing and crowding. It generally has not been indicated in more complicated malocclusions such as skeletal discrepancies and open bites; however, recent advances in technology and practitioner expertise now allow the use of CAT in these situations. This case report demonstrates the use of a CAT system (Invisalign) to correct a Class II malocclusion with crowding and an open bite tendency.

  8. Improved Estimates of Clear Sky Longwave Flux and Application to the Tropical Greenhouse Effect

    Science.gov (United States)

    Collins, W. D.

    1997-01-01

    The first objective of this investigation is to eliminate the clear-sky offset introduced by the scene-identification procedures developed for the Earth Radiation Budget Experiment (ERBE). Estimates of this systematic bias range from 10 to as high as 30 W/sq m. The initial version of the ScaRaB data is being processed with the original ERBE algorithm. Since the ERBE procedure for scene identification is based upon zonal flux averages, clear scenes with longwave emission well below the zonal mean value are mistakenly classified as cloudy. The erroneous classification is more frequent in regions with deep convection and enhanced mid- and upper-tropospheric humidity. We will develop scene identification parameters with zonal and/or time dependence to reduce or eliminate the bias in the clear- sky data. The modified scene identification procedure could be used for the ScaRaB-specific version of the Earth-radiation products. The second objective is to investigate changes in the clear-sky Outgoing Longwave Radiation (OLR) associated with decadal variations in the tropical and subtropical climate. There is considerable evidence for a shift in the climate state starting in approximately 1977. The shift is accompanied by higher SSTs in the equatorial Pacific, increased tropical convection, and higher values of atmospheric humidity. Other evidence indicates that the humidity in the tropical troposphere has been steadily increasing over the last 30 years. It is not known whether the atmospheric greenhouse effect has increased during this period in response to these changes in SST and precipitable water. We will investigate the decadal-scale fluctuations in the greenhouse effect using Nimbus-7, ERBE, and ScaRaB measurements spaning 1979 to the present. The data from the different satellites will be intercalibrated by comparison with model calculations based upon ship radiosonde observations. The fluxes calculated from the radiation model will also be used for validation of the

  9. A Mass balance mercury budget for a mine-dominated lake: Clear Lake, California

    Science.gov (United States)

    Suchanek, T.H.; Cooke, J.; Keller, K.; Jorgensen, S.; Richerson, P.J.; Eagles-Smith, C. A.; Harner, E.J.; Adam, D.P.

    2009-01-01

    The Sulphur Bank Mercury Mine (SBMM), active intermittently from 1873-1957 and now a USEPA Superfund site, was previously estimated to have contributed at least 100 metric tons (105 kg) of mercury (Hg) into the Clear Lake aquatic ecosystem. We have confirmed this minimum estimate. To better quantify the contribution of the mine in relation to other sources of Hg loading into Clear Lake and provide data that might help reduce that loading, we analyzed Inputs and Outputs of Hg to Clear Lake and Storage of Hg in lakebed sediments using a mass balance approach. We evaluated Inputs from (1) wet and dry atmospheric deposition from both global/regional and local sources, (2) watershed tributaries, (3) groundwater inflows, (4) lakebed springs and (5) the mine. Outputs were quantified from (1) efflux (volatilization) of Hg from the lake surface to the atmosphere, (2) municipal and agricultural water diversions, (3) losses from out-flowing drainage of Cache Creek that feeds into the California Central Valley and (4) biotic Hg removal by humans and wildlife. Storage estimates include (1) sediment burial from historic and prehistoric periods (over the past 150-3,000 years) from sediment cores to ca. 2.5m depth dated using dichloro diphenyl dichloroethane (DDD), 210Pb and 14C and (2) recent Hg deposition in surficial sediments. Surficial sediments collected in October 2003 (11 years after mine site remediation) indicate no reduction (but a possible increase) in sediment Hg concentrations over that time and suggest that remediation has not significantly reduced overall Hg loading to the lake. Currently, the mine is believed to contribute ca. 322-331 kg of Hg annually to Clear Lake, which represents ca. 86-99% of the total Hg loading to the lake. We estimate that natural sedimentation would cover the existing contaminated sediments within ca. 150-300 years. ?? 2008 Springer Science+Business Media B.V.

  10. Common knowledge of rationality and market clearing in economies with asymmetric information

    OpenAIRE

    Ben-Porath, Elchanan; HEIFETZ , Aviad

    2010-01-01

    Consider an exchange economy with asymmetric information. What is the set of outcomes that are consistent with common knowledge of rationality and market clearing? To address this question we define an epistemic model for the economy that provides a complete description not only of the beliefs of each agent on the relationship between states of nature and prices but also of the whole system of interactive beliefs. The main result, theorem 1, provides a characterization of outcomes that are co...

  11. Time-on-task decrements in "steer clear" performance of patients with sleep apnea and narcolepsy

    Science.gov (United States)

    Findley, L. J.; Suratt, P. M.; Dinges, D. F.

    1999-01-01

    Loss of attention with time-on-task reflects the increasing instability of the waking state during performance in experimentally induced sleepiness. To determine whether patients with disorders of excessive sleepiness also displayed time-on-task decrements indicative of wake state instability, visual sustained attention performance on "Steer Clear," a computerized simple RT driving simulation task, was compared among 31 patients with untreated sleep apnea, 16 patients with narcolepsy, and 14 healthy control subjects. Vigilance decrement functions were generated by analyzing the number of collisions in each of six four-minute periods of Steer Clear task performance in a mixed-model analysis of variance and linear regression equations. As expected, patients had more Steer Clear collisions than control subjects (p=0.006). However, the inter-subject variability in errors among the narcoleptic patients was four-fold that of the apnea patients, and 100-fold that of the controls volunteers; the variance in errors among untreated apnea patients was 27-times that of controls. The results of transformed collision data revealed main effects for group (p=0.006), time-on-task (p=0.001), and a significant interaction (p=0.022). Control subjects showed no clear evidence of increasing collision errors with time-on-task (adjusted R2=0.22), while apnea patients showed a trend toward vigilance decrement (adjusted R2=0.42, p=0.097), and narcolepsy patients evidenced a robust linear vigilance decrement (adjusted R2=0.87, p=0.004). The association of disorders of excessive somnolence with escalating time-on-task decrements makes it imperative that when assessment of neurobehavioral performance is conducted in patients, it involves task durations and analyses that will evaluate the underlying vulnerability of potentially sleepy patients to decrements over time in tasks that require sustained attention and timely responses, both of which are key components in safe driving performance.

  12. A Link between mir-100 and FRAP1/mTOR in Clear Cell Ovarian Cancer

    Science.gov (United States)

    Nagaraja, Ankur K.; Creighton, Chad J.; Yu, Zhifeng; Zhu, Huifeng; Gunaratne, Preethi H.; Reid, Jeffrey G.; Olokpa, Emuejevoke; Itamochi, Hiroaki; Ueno, Naoto T.; Hawkins, Shannon M.; Anderson, Matthew L.; Matzuk, Martin M.

    2010-01-01

    MicroRNAs (miRNAs) are small noncoding RNAs that direct gene regulation through translational repression and degradation of complementary mRNA. Although miRNAs have been implicated as oncogenes and tumor suppressors in a variety of human cancers, functional roles for individual miRNAs have not been described in clear cell ovarian carcinoma, an aggressive and chemoresistant subtype of ovarian cancer. We performed deep sequencing to comprehensively profile miRNA expression in 10 human clear cell ovarian cancer cell lines compared with normal ovarian surface epithelial cultures and discovered 54 miRNAs that were aberrantly expressed. Because of the critical roles of the phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene homolog 1/mammalian target of rapamycin (mTOR) pathway in clear cell ovarian cancer, we focused on mir-100, a putative tumor suppressor that was the most down-regulated miRNA in our cancer cell lines, and its up-regulated target, FRAP1/mTOR. Overexpression of mir-100 inhibited mTOR signaling and enhanced sensitivity to the rapamycin analog RAD001 (everolimus), confirming the key relationship between mir-100 and the mTOR pathway. Furthermore, overexpression of the putative tumor suppressor mir-22 repressed the EVI1 oncogene, which is known to suppress apoptosis by stimulating phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene homolog 1 signaling. In addition to these specific effects, reversing the expression of mir-22 and the putative oncogene mir-182 had widespread effects on target and nontarget gene populations that ultimately caused a global shift in the cancer gene signature toward a more normal state. Our experiments have revealed strong candidate miRNAs and their target genes that may contribute to the pathogenesis of clear cell ovarian cancer, thereby highlighting alternative therapeutic strategies for the treatment of this deadly cancer. PMID:20081105

  13. POSTMENOPAUSAL BLEEDING: HISTOPATHOLOGICAL SPECTRUM AND ASSOCIATION WITH AGE AND CLEAR SPAN: CASE SERIES OF 328 CASES

    Directory of Open Access Journals (Sweden)

    Ruchita

    2014-06-01

    Full Text Available : Introduction: Postmenopausal bleeding is defined as vaginal bleeding occurring after twelve months of amenorrhea in a woman of the age where the menopause can be expected. With increase in life expectancy, a larger proportion of female population will be in postmenopausal age group; hence, the incidence of postmenopausal bleeding is expected to increase. AIM: We studied the prevalence of malignancy as well as the histopathological spectrum of genital tract lesions in cases of postmenopausal bleeding. The association between age, period between cessation of menses and onset of bleeding per vaginum (clear span was also studied. RESULTS: Malignant causes were more common (58.5% than benign causes and included cervical carcinoma, malignant uterine tumors (13.1%, carcinoma vagina (4.3%, malignant ovarian tumors (5.5%, carcinoma vulva (0.9% and carcinoma fallopian tube (0.3%. Squamous cell carcinoma was the commonest among cervical malignancies. The benign causes included polyps (16.5%, endometrial hyperplasia (4.9%, adenomyosis (2.7%, atrophic endometrium (2.4%, cervicitis (2.1%, leiomyoma (1.8%, proliferative endometrium (1.5%, endometritis (1.5%, secretory endometrium (1.2%, retained IUCD (0.9% and uterovaginal prolapse (0.6%. The likelihood of malignancy increased significantly with advancing age (p-value 0.042. The clear span of cases with malignant tumors was significantly longer than the clear span of cases with benign lesions. Hence, the likelihood of malignancy increased with length of clear span (p-value 0.00809. CONCLUSION: Any postmenopausal patient with vaginal bleeding needs to be investigated thoroughly to determine the cause of the bleeding and should be considered to have abnormal histopathology until proved otherwise

  14. Renal cell carcinoma with areas mimicking renal angiomyoadenomatous tumor/clear cell papillary renal cell carcinoma.

    Science.gov (United States)

    Petersson, Fredrik; Grossmann, Petr; Hora, Milan; Sperga, Maris; Montiel, Delia Perez; Martinek, Petr; Gutierrez, Maria Evelyn Cortes; Bulimbasic, Stela; Michal, Michal; Branzovsky, Jindrich; Hes, Ondrej

    2013-07-01

    We present a cohort of 8 renal carcinomas that displayed a variable (5%-95% extent) light microscopic appearance of renal angiomyoadenomatous tumor/clear cell papillary renal cell carcinoma (RAT/CCPRCC) without fulfilling the criteria for these tumors. All but 1 case predominantly (75%-95% extent) showed histopathologic features of conventional clear cell renal cell carcinoma. In 5 of 7 cases with mostly conventional clear renal cell carcinoma (CRCC) morphology, a diagnosis of CRCC was supported by the molecular genetic findings (presence of von Hippel-Lindau tumor suppressor [VHL] mutation and/or VHL promoter methylation and/or loss of heterozygosity [LOH] for 3p). Of the other 2 cases with predominantly characteristic CRCC morphology, 1 tumor did not reveal any VHL mutation, VHL promoter methylation, or LOH for 3p, and both chromosomes 7 and 17 were disomic, whereas the other tumor displayed polysomy for chromosomes 7 and 17 and no VHL mutation, VHL promoter methylation, or LOH for 3p. One tumor was composed primarily (95%) of distinctly RAT/CCPRCC-like morphology, and this tumor harbored a VHL mutation and displayed polysomy for chromosomes 7 and 17. Of the 5 cases with both histomorphologic features and molecular genetic findings of CRCC, we detected significant immunoreactivity for α-methylacyl-CoA racemase in 2 cases and strong diffuse immunopositivity for cytokeratin 7 in 3 cases. Despite the combination of positivity for α-methylacyl-CoA racemase and cytokeratin 7 in 2 cases, there was nothing to suggest of the possibility of a conventional papillary renal cell carcinoma with a predominance of clear cells.

  15. Clear-Sky Narrowband Albedo Variations Derived from VIRS and MODIS Data

    Science.gov (United States)

    Sun-Mack, Sunny; Chen, Yan; Arduini, Robert F.; Minnis, Patrick

    2004-01-01

    A critical parameter for detecting clouds and aerosols and for retrieving their microphysical properties is the clear-sky radiance. The Clouds and the Earth's Radiant Energy System (CERES) Project uses the visible (VIS; 0.63 m) and near-infrared (NIR; 1.6 or 2.13 m) channels available on same satellites as the CERES scanners. Another channel often used for cloud and aerosol, and vegetation cover retrievals is the vegetation (VEG; 0.86- m) channel that has been available on the Advanced Very High Resolution Radiometer (AVHRR) for many years. Generally, clear-sky albedo for a given surface type is determined for conditions when the vegetation is either thriving or dormant and free of snow. Snow albedo is typically estimated without considering the underlying surface type. The albedo for a surface blanketed by snow, however, should vary with surface type because the vegetation often emerges from the snow to varying degrees depending on the vertical dimensions of the vegetation. For example, a snowcovered prairie will probably be brighter than a snowcovered forest because the snow typically falls off the trees exposing the darker surfaces while the snow on a grassland at the same temperatures will likely be continuous and, therefore, more reflective. Accounting for the vegetation-induced differences should improve the capabilities for distinguishing snow and clouds over different surface types and facilitate improvements in the accuracy of radiative transfer calculations between the snow-covered surface and the atmosphere, eventually leading to improvements in models of the energy budgets over land. This paper presents a more complete analysis of the CERES spectral clear-sky reflectances to determine the variations in clear-sky top-of-atmosphere (TOA) albedos for both snow-free and snow-covered surfaces for four spectral channels using data from Terra and Aqua.. The results should be valuable for improved cloud retrievals and for modeling radiation fields.

  16. Microstructured glazing for daylighting, glare protection, seasonal thermal control and clear view

    OpenAIRE

    Kostro, André Gabriel

    2015-01-01

    The appropriate choice of glazing in a facade depends on many factors. They include amongst other criteria: location, orientation, climatic condition, energetic efficiency, usage of the building, required user comfort, and the architectural concept. On the south facade of high-rise buildings in particular, it is a challenge to have simultaneously large glazed area, no glare, no excessive cooling loads, a clear view and sufficient natural light flux. In Switzerland, electric lighting, heating ...

  17. Stakeholder Perceptions of an Ecosystem Services Approach to Clearing Invasive Alien Plants on Private Land

    Directory of Open Access Journals (Sweden)

    Lauren S. Urgenson

    2013-03-01

    Full Text Available Incentivizing private landowners and other stakeholders is central to the effective conservation of ecosystem services in working landscapes. To better understand how to design effective incentives, the perceptions of landowners and other stakeholders are explored regarding a proposed approach to clearing invasive alien plants on private land in the Western Cape Province, South Africa. The public funded national program, Working for Water, conserves ecosystem services while employing and training people from marginalized sectors of society to clear these plants. Private landowner involvement is a key conservation challenge, because without adequate landowner involvement, invasive alien plants persist on the landscape and continuously reinvade cleared areas. We collected interview data from private landowners in three study sites, and web-survey data from conservation professionals and Working for Water managers, in order to compare stakeholder perceptions of (1 government and landowners' responsibilities for clearing invasive alien plants; (2 existing and proposed policy tools; and (3 the extent to which stakeholders consider the proposed financial incentive to be sufficient. There was significant consensus among stakeholders concerning their preference for shared landowner and government responsibility and for a policy mix that combines incentives with disincentives. Landowners from the three study sites differed in the level of responsibility they were willing to assume. Stakeholders also diverged in terms of their perceptions of the proposed financial incentives. Furthermore, the perspectives of landowners were strongly associated with ecological and social features of the landscapes in which they are located. Understanding stakeholders' points of view within their differing contexts is shown to be a valuable means of gaining insight into the opportunities and constraints that face ecosystem service conservation in working landscapes.

  18. A novel grading system for clear cell renal cell carcinoma incorporating tumor necrosis.

    Science.gov (United States)

    Delahunt, Brett; McKenney, Jesse K; Lohse, Christine M; Leibovich, Bradley C; Thompson, Robert Houston; Boorjian, Stephen A; Cheville, John C

    2013-03-01

    Grading of renal cell carcinoma (RCC) has prognostic significance, and there is recent consensus by the International Society of Urological Pathology (ISUP) that for clear cell and papillary RCC, grading should primarily be based on nucleolar prominence. Microscopic tumor necrosis also predicts outcome independent of tumor grading. This study was undertaken to assess whether the incorporation of microscopic tumor necrosis into the ISUP grading system provides survival information superior to ISUP grading alone. Data on 3017 patients treated surgically for clear cell RCC, 556 for papillary RCC, and 180 for chromophobe RCC were retrieved from the Mayo Clinic Registry. Median follow-up periods were 8.9, 9.7, and 8.5 years, respectively. Four proposed grades were defined: grade 1: ISUP grade 1+ISUP grade 2 without necrosis; grade 2: ISUP grade 2 with necrosis+ISUP grade 3 without necrosis; grade 3: ISUP grade 3 with necrosis+ISUP grade 4 without necrosis; grade 4: ISUP grade 4 with necrosis or sarcomatoid/rhabdoid tumors. There was a significant difference in survival between each of the grades for clear cell RCC, and the concordance index was superior to that of ISUP grading. The proposed grading system also outperformed the ISUP grading system when cases were stratified according to the TNM stage. Similar results were not obtained for papillary RCC or chromophobe RCC. We conclude that grading for clear cell RCC should be based on nucleolar prominence and necrosis, that ISUP grading should be used for papillary RCC, and that chromophobe RCC should not be graded.

  19. Optical clearing agent perfusion enhancement via combination of microneedle poration, heating and pneumatic pressure

    OpenAIRE

    Damestani, Y; Melakeberhan, B; Rao, MP; Aguilar, G.

    2014-01-01

    Background and Objective Optical clearing agents (OCAs) have shown promise for increasing the penetration depth of biomedical lasers by temporarily decreasing optical scattering within the skin. However, their translation to the clinic has been constrained by lack of practical means for effectively perfusing OCA within target tissues in vivo. The objective of this study was to address this limitation through combination of a variety of techniques to enhance OCA perfusion, including heating of...

  20. Spectrally-selective all-inorganic scattering luminophores for solar energy-harvesting clear glass windows

    Science.gov (United States)

    Alghamedi, Ramzy; Vasiliev, Mikhail; Nur-E-Alam, Mohammad; Alameh, Kamal

    2014-10-01

    All-inorganic visibly-transparent energy-harvesting clear laminated glass windows are the most practical solution to boosting building-integrated photovoltaics (BIPV) energy outputs significantly while reducing cooling- and heating-related energy consumption in buildings. By incorporating luminophore materials into lamination interlayers and using spectrally-selective thin-film coatings in conjunction with CuInSe2 solar cells, most of the visible solar radiation can be transmitted through the glass window with minimum attenuation while ultraviolet (UV) radiation is down-converted and routed together with a significant part of infrared radiation to the edges for collection by solar cells. Experimental results demonstrate a 10 cm × 10 cm vertically-placed energy-harvesting clear glass panel of transparency exceeding 60%, invisible solar energy attenuation greater than 90% and electrical power output near 30 Wp/m2 mainly generated by infrared (IR) and UV radiations. These results open the way for the realization of large-area visibly-transparent energy-harvesting clear glass windows for BIPV systems.

  1. Spectrally-selective all-inorganic scattering luminophores for solar energy-harvesting clear glass windows.

    Science.gov (United States)

    Alghamedi, Ramzy; Vasiliev, Mikhail; Nur-E-Alam, Mohammad; Alameh, Kamal

    2014-10-16

    All-inorganic visibly-transparent energy-harvesting clear laminated glass windows are the most practical solution to boosting building-integrated photovoltaics (BIPV) energy outputs significantly while reducing cooling- and heating-related energy consumption in buildings. By incorporating luminophore materials into lamination interlayers and using spectrally-selective thin-film coatings in conjunction with CuInSe2 solar cells, most of the visible solar radiation can be transmitted through the glass window with minimum attenuation while ultraviolet (UV) radiation is down-converted and routed together with a significant part of infrared radiation to the edges for collection by solar cells. Experimental results demonstrate a 10 cm × 10 cm vertically-placed energy-harvesting clear glass panel of transparency exceeding 60%, invisible solar energy attenuation greater than 90% and electrical power output near 30 Wp/m(2) mainly generated by infrared (IR) and UV radiations. These results open the way for the realization of large-area visibly-transparent energy-harvesting clear glass windows for BIPV systems.

  2. Clear widens the field for observations of the Sun with multi-conjugate adaptive optics

    Science.gov (United States)

    Schmidt, Dirk; Gorceix, Nicolas; Goode, Philip R.; Marino, Jose; Rimmele, Thomas; Berkefeld, Thomas; Wöger, Friedrich; Zhang, Xianyu; Rigaut, François; von der Lühe, Oskar

    2017-01-01

    The multi-conjugate adaptive optics (MCAO) pathfinder Clear on the New Solar Telescope in Big Bear Lake has provided the first-ever MCAO-corrected observations of the Sun that show a clearly and visibly widened corrected field of view compared to quasi-simultaneous observations with classical adaptive optics (CAO) correction. Clear simultaneously uses three deformable mirrors, each conjugated to a different altitude, to compensate for atmospheric turbulence. While the MCAO correction was most effective over an angle that is approximately three times wider than the angle that was corrected by CAO, the full 53'' field of view did benefit from MCAO correction. We further demonstrate that ground-layer-only correction is attractive for solar observations as a complementary flavor of adaptive optics for observational programs that require homogenous seeing improvement over a wide field rather than diffraction-limited resolution. We show illustrative images of solar granulation and of a sunspot obtained on different days in July 2016, and present a brief quantitative analysis of the generalized Fried parameters of the images. The movies associated to Fig. 1 are available at http://www.aanda.org

  3. Clearing the Gas from Globular Clusters & Dwarf Spheroidals with Classical Novae

    CERN Document Server

    Moore, Kevin

    2010-01-01

    Observations of the intra-cluster medium (ICM) in galactic globular clusters (GCs) show a systematic deficiency in ICM mass as compared to that expected from accumulation of stellar winds in the time available between galactic plane crossings. In this paper, we reexamine the original hypothesis of Scott and Durisen that hydrogen-rich explosions on accreting white dwarfs, classical novae (CNe), will sweep out the ICM from the cluster more frequently than galactic plane crossings. From the CNe rate and stellar mass-loss rate, this clearing mechanism predicts that ~ 0.03 M_sun should be present in 5x10^5 M_sun) GCs. We find that nova shells are effective at clearing the ICM in low-mass GCs (<= 10^5 M_sun), whereas higher-mass clusters may experience a quiescent time between novae long enough to prevent the next nova shell from escaping. The nova clearing mechanism will also operate in ultra-faint Milky Way satellites, where many upper limits on gas masses are available.

  4. Clear Corneal Phacovitrectomy with Posterior Capsulorhexis and IOL Implantation in Management of Selective Vitreoretinal Cases

    Directory of Open Access Journals (Sweden)

    Ernest V. Boiko

    2015-01-01

    Full Text Available Purpose. To describe our technique, clear corneal phacovitrectomy with posterior capsulorhexis (CCPV, for the management of selected posterior segment intraocular foreign body (IOFB, posteriorly dislocated lens fragments (PDLF, and proliferative diabetic retinopathy (PDR cases. Methods. This was a single-center retrospective interventional case series. In 21 patients (21 eyes we performed phacovitrectomy through three clear corneal tunnel incisions (CCTI and posterior capsulorhexis to remove IOFB (n=8, PDLF from the vitreous cavity after complicated phacoemulsification (n=6, and vitreous hemorrhage and epiretinal membranes in PDR (n=7. The procedure was completed with implantation of a hydrophobic acrylic IOL through the CCTI. Results. The mean visual acuity (logMAR was 0.90 preoperative and improved to 0.26 over a mean follow-up of 8.7 months (range, 6–12 months. The intraocular lens was implanted into the capsular bag (n=12 or onto the anterior capsule (n=9. One PDR patient experienced an intraprocedural complication, hemorrhage from isolated fibrovascular adhesions. One IOFB patient developed apparent anterior proliferative vitreoretinopathy and required a repeat intervention. Conclusion. Selected vitreoretinal IOFB, PDLF, and PDR cases can be successfully managed by a combined surgical approach involving clear corneal phacovitrectomy with posterior capsulorhexis and implantation of an IOL, with good visual outcome and a low complication rate.

  5. Clear Corneal Phacovitrectomy with Posterior Capsulorhexis and IOL Implantation in Management of Selective Vitreoretinal Cases.

    Science.gov (United States)

    Boiko, Ernest V; Churashov, Sergey V; Kulikov, Alexei N; Maltsev, Dmitrii S

    2015-01-01

    Purpose. To describe our technique, clear corneal phacovitrectomy with posterior capsulorhexis (CCPV), for the management of selected posterior segment intraocular foreign body (IOFB), posteriorly dislocated lens fragments (PDLF), and proliferative diabetic retinopathy (PDR) cases. Methods. This was a single-center retrospective interventional case series. In 21 patients (21 eyes) we performed phacovitrectomy through three clear corneal tunnel incisions (CCTI) and posterior capsulorhexis to remove IOFB (n = 8), PDLF from the vitreous cavity after complicated phacoemulsification (n = 6), and vitreous hemorrhage and epiretinal membranes in PDR (n = 7). The procedure was completed with implantation of a hydrophobic acrylic IOL through the CCTI. Results. The mean visual acuity (logMAR) was 0.90 preoperative and improved to 0.26 over a mean follow-up of 8.7 months (range, 6-12 months). The intraocular lens was implanted into the capsular bag (n = 12) or onto the anterior capsule (n = 9). One PDR patient experienced an intraprocedural complication, hemorrhage from isolated fibrovascular adhesions. One IOFB patient developed apparent anterior proliferative vitreoretinopathy and required a repeat intervention. Conclusion. Selected vitreoretinal IOFB, PDLF, and PDR cases can be successfully managed by a combined surgical approach involving clear corneal phacovitrectomy with posterior capsulorhexis and implantation of an IOL, with good visual outcome and a low complication rate.

  6. Multiparametric magnetic resonance imaging for the differentiation of low and high grade clear cell renal carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Cornelis, F.; Tricaud, E.; Lasserre, A.S.; Petitpierre, F.; Le Bras, Y.; Bouzgarrou, M.; Grenier, N. [Pellegrin Hospital, Department of Radiology, Bordeaux (France); Bernhard, J.C. [Pellegrin Hospital, Department of Urology, Bordeaux (France); Yacoub, M. [Pellegrin Hospital, Department of Pathology, Bordeaux (France); Ravaud, A. [Saint-Andre Hospital, Department of Oncology, Bordeaux (France)

    2015-01-15

    To retrospectively evaluate the ability of magnetic resonance (MR) imaging to differentiate low from high Fuhrman grade renal cell carcinoma (RCC). MR images from 80 consecutive pathologically proven RCC (57 clear cell, 16 papillary and 7 chromophobe) were evaluated. Double-echo chemical shift, dynamic contrast-enhanced T1- and T2-weighted images and apparent diffusion coefficient (ADC) maps were reviewed independently. Signal intensity index (SII), tumour-to-spleen SI ratio (TSR), ADC ratio, wash-in (WiI) and wash-out indices (WoI) between different phases were calculated and compared to pathological grade and size. The Fuhrman scoring system was used. Low grade (score ≤2) and high grade (score ≥3) tumours were compared using univariate and multivariate analyses. No associations between grade and imaging factors were found for papillary and chromophobe RCCs. For clear cell RCCs, there was a significant association between the grade and parenchymal WiI (WiI2) (P = 0.02) or ADCr (P = 0.03). A significant association between tumour grade and size (P = 0.01), WiI2 (P = 0.02) and ADCr (P = 0.05) remained in multivariate analysis. Multiparametric MRI can be used to accurately differentiate low Fuhrman grade clear cell RCC from high grade. High Fuhrman grade (≥3) RCCs were larger, had lower parenchymal wash-in indices and lower ADC ratios than low grade. (orig.)

  7. Comparing the efficacy of coconut oil and xylene as a clearing agent in the histopathology laboratory

    Directory of Open Access Journals (Sweden)

    Wajid Sermadi

    2014-01-01

    Full Text Available Background: The commonly used clearing agent, xylene is supposed to be highly toxic and carcinogenic. As previous research studies have shown the effectiveness of different vegetable oils as clearants, this study was designed to evaluate the efficacy of coconut oil. Materials and Methods: Two equal halves of 60 soft tissue specimens were processed simultaneously in xylene and coconut oil as clearing agents. The Xylene-treated specimens (XY-S and Coconut oil-treated specimens (CO-S were checked for gross and histological features and comparison was done between the two groups. Results: Significant shrinkage was noted in XY-S compared to that in CO-S. No difference was found in either of the sections when checked for cellular details and staining quality. Morphometrically, there was significant reduction in the mean cell area in XY-S compared to that in CO-S. Conclusion: Coconut oil may be substituted for the highly hazardous xylene as a clearing agent without compromising the quality of histological details.

  8. Affect of a clear-sky bias on inversions of XCO2

    Science.gov (United States)

    Marshall, Julia; Jung, Martin; Rödenbeck, Christian; Heimann, Martin

    2016-04-01

    Since GOSAT XCO2 data have become available, several studies have illustrated the systematic differences seen in flux patterns based on inversions of surface measurements vs. those based on satellite measurements. Across retrievals, transport models, and inversion setups, a clear shift towards larger sources from the tropics and a stronger sinks from the extratropics is seen, often so marked that the two results are not statistically consistent with one another within uncertainty bounds. Some studies have attributed this redistribution of fluxes to biases in the measurements, perhaps the result of inappropriately defined prior covariance assumptions in the satellite retrieval, while others have argued that the result is robust. One aspect that has not been explored thoroughly is the possibility that this difference might be the result of a clear-sky bias in the measurements. By measuring only when there are gaps in the cloud, the satellite measurements are skewed toward sampling in conditions of higher uptake. Analysis using flux tower data shows the effect of this to be regionally dependent with a strong seasonal signal, resulting in an overestimation in uptake in the northern hemisphere extratropics. We extend the analysis using upscaled products to assess the impact on the cumulative NEE fluxes at the time of satellite overpass, comparing the all-sky values to those with clear-sky conditions. This difference in cumulative fluxes is translated into an offset in XCO2, and the impact on inverted fluxes is shown. Potential strategies to overcome such a systematic bias are discussed.

  9. Super-Resolution Mapping of Neuronal Circuitry With an Index-Optimized Clearing Agent

    Directory of Open Access Journals (Sweden)

    Meng-Tsen Ke

    2016-03-01

    Full Text Available Super-resolution imaging deep inside tissues has been challenging, as it is extremely sensitive to light scattering and spherical aberrations. Here, we report an optimized optical clearing agent for high-resolution fluorescence imaging (SeeDB2. SeeDB2 matches the refractive indices of fixed tissues to that of immersion oil (1.518, thus minimizing both light scattering and spherical aberrations. During the clearing process, fine morphology and fluorescent proteins were highly preserved. SeeDB2 enabled super-resolution microscopy of various tissue samples up to a depth of >100 μm, an order of magnitude deeper than previously possible under standard mounting conditions. Using this approach, we demonstrate accumulation of inhibitory synapses on spine heads in NMDA-receptor-deficient neurons. In the fly medulla, we found unexpected heterogeneity in axon bouton orientations among Mi1 neurons, a part of the motion detection circuitry. Thus, volumetric super-resolution microscopy of cleared tissues is a powerful strategy in connectomic studies at synaptic levels.

  10. Combined 23-gauge sutureless vitrectomy and clear corneal phacoemulsification for rhegmatogenous retinal detachment repair

    Institute of Scientific and Technical Information of China (English)

    Hoseok; Moon; Hee; Jin; Sohn; Dea; Yeong; Lee; Jong; Yeon; Lee; Dong; Heun; Nam

    2015-01-01

    AIM: To assess the outcomes of combined 23-gauge sutureless vitrectomy and clear corneal phacoemulsification with intraocular lens implantation for rhegmatogenous retinal detachment(RRD) repair.METHODS: This was a retrospective, consecutive,noncomparative, interventional case series of 30 eyes of30 patients who underwent combined sutureless vitrectomy and clear corneal cataract surgery for the repair of RRD. The principal outcome measures were primary anatomical success rate, reasons for redetachment, final visual acuity, and surgical complications.RESULTS: Primary reattachment was achieved in 27eyes(90.0%). The reasons for redetachment(3 eyes, 10%)were incomplete laser retinopexy, persistent chronic subretinal fluid, and proliferative vitreoretinopathy,respectively. The logarithm of the minimum angle of resolution visual acuity(mean±SD) improved from 0.76±0.74 preoperatively to 0. 21 ± 0. 37 6 months’ postoperatively(P <0.0001). Postoperative hypotony was not detected,but 1 eye( 3. 3 %) had increased intraocular pressure(30 mm Hg) with spontaneous resolution. No endophthalmitis developed during follow-up. Macular pucker was detected in 3 eyes(10.0%).· CONCLUSION: Combined 23-gauge sutureless vitrectomy and clear corneal phacoemulsification with intraocular lens implantation for RRD repair was proven safe and effective. It may provide not only the known advantages of conventional combined surgery, but also additional advantages such as less conjunctival fibrosis and the maintenance of stable intraocular pressure with low risks of postoperative hypotony and intraocular pressure elevation.

  11. As clear as mud: Turbidity induces behavioral changes in the African cichlid Pseudocrenilabrus multicolor

    Directory of Open Access Journals (Sweden)

    Suzanne M. GRAY, Laura H. McDONNELL, Fabio G. CINQUEMANI,Lauren J. CHAPMAN

    2012-02-01

    Full Text Available Aquatic biodiversity is being lost at an unprecedented rate. One factor driving this loss is increased turbidity, an environmental stressor that can impose behavioral, morphological, and/or physiological costs on fishes. Here we describe the behavioral response of a widespread African cichlid, Pseudocrenilabrus multicolor victoriae, to turbidity. We used a split-brood rearing design to test if F1 offspring reared in turbid water, originating from river (turbid and swamp (clear populations, behave differently than full-sibs reared in clear water. We examined two facets of behavior: (1 behaviors of fish in full sib groups, including activity level and social dynamics collected during the rearing period; and (2 male aggressive behavior directed at potential male competitors after fish had reached maturity; this was done in an experimental set-up independent of the rearing aquaria. Regardless of population of origin, fish reared in turbid water were marginally less active and performed fewer social behaviors than those reared in clear water. On the other hand, when tested against a competitor in turbid water, males performed more aggressive behaviors, regardless of population of origin or rearing environment. Our results suggest a plastic behavioral response to turbidity that may allow P. multicolor to persist over a range of turbidity levels in nature by decreasing activity and general social behaviors and intensifying reproductive behaviors to ensure reproductive success [Current Zoology 58 (1: 146–157, 2012].

  12. A rapid and reversible skull optical clearing method for monitoring cortical blood flow

    Science.gov (United States)

    Zhang, Chao; Zhao, Yanjie; Shi, Rui; Zhu, Dan

    2016-03-01

    In vivo cortex optical imaging is of great important for revealing both structural and functional architecture of brain with high temporal-spatial resolution. To reduce the limitation of turbid skull, researchers had to establish various skull windows or directly expose cortex through craniotomy. Here we developed a skull optical clearing method to make skull transparent. Laser speckle contrast imaging technique was used to monitor the cortical blood flow after topical treatment with the optical clearing agents. The results indicated that the image contrast increased gradually, and then maintained at a high level after 15 min for adult mice, which made the image quality and resolution of micro-vessels nearly approximate to those of exposed cortex. Both the cortical blood flow velocity almost kept constant after skull became transparent. Besides, the treatment of physiological saline on the skull could make skull return to the initial state again and the skull could become transparent again when SOCS retreated it. Thus, we could conclude that the skull optical clearing method was rapid, valid, reversible and safe, which provided us available approach for performing the cortical structural and functional imaging at high temporal-spatial resolution.

  13. Ultraviolet actinic flux in clear and cloudy atmospheres: model calculations and aircraft-based measurements

    Directory of Open Access Journals (Sweden)

    G. G. Palancar

    2011-01-01

    Full Text Available Ultraviolet (UV actinic fluxes measured with two Scanning Actinic Flux Spectroradiometers (SAFS aboard the NASA DC-8 aircraft are compared with the Tropospheric Ultraviolet-Visible (TUV model. The observations from 17 days in July–August 2004 (INTEX-NA field campaign span a wide range of latitudes (27.5° N–53.0° N, longitudes (45.1° W–139.5° W, altitudes (0.1–11.9 km, ozone columns (285.4–352.7 DU, and solar zenith angles (1.7°–85°. Both cloudy and cloud-free conditions were encountered. For cloud-free conditions, the ratio of observed to clear-sky-model actinic flux (integrated from 298 to 422 nm is 1.01±0.04, i.e. in good agreement with observations. The agreement improves to 1.00±0.03 for the down-welling component under clear sky conditions. In the presence of clouds, both down-welling and up-welling components show reductions or enhancements from clear sky values, depending on the position of the airplane relative to clouds. The correlations between up-welling and down-welling deviations are well reproduced with sensitivity studies using the TUV model, and are understood qualitatively with a simple conceptual model. This analysis of actinic flux observations illustrates opportunities for future evaluations of photolysis rates in three-dimensional chemistry-transport models.

  14. As clear as mud: Turbidity induces behavioral changes in the African cichlid Pseudocrenilabrus multicolor

    Institute of Scientific and Technical Information of China (English)

    Suzanne M. GRAY; Laura H. McDONNELL; Fabio G. CINQUEMANI; Lauren J. CHAPMAN

    2012-01-01

    Aquatic biodiversity is being lost at an unprecedented rate.One factor driving this loss is increased turbidity,an environmental stressor that can impose behavioral,morphological,and/or physiological costs on fishes.Here we describe the behavioral response of a widespread African cichlid,Pseudocrenilabrus multicolor victoriae,to turbidity.We used a split-brood rearing design to test if F1 offspring reared in turbid water,originating from river (turbid) and swamp (clear) populations,behave differently than full-sibs reared in clear water.We examined two facets of behavior:(1) behaviors of fish in full sib groups,including activity level and social dynamics collected during the rearing period; and (2) male aggressive behavior directed at potential male competitors after fish had reached maturity; this was done in an experimental set-up independent of the rearing aquaria.Regardless of population of origin,fish reared in turbid water were marginally less active and performed fewer social behaviors than those reared in clear water.On the other hand,when tested against a competitor in turbid water,males performed more aggressive behaviors,regardless of population of origin or rearing environment.Our results suggest a plastic behavioral response to turbidity that may allow P multicolor to persist over a range of turbidity levels in nature by decreasing activity and general social behaviors and intensifying reproductive behaviors to ensure reproductive success [ Current Zoology 58 (1):146-157,2012].

  15. 77 FR 33013 - Self-Regulatory Organizations; ICE Clear Credit LLC; Notice of Designation of a Longer Period for...

    Science.gov (United States)

    2012-06-04

    ... COMMISSION Self-Regulatory Organizations; ICE Clear Credit LLC; Notice of Designation of a Longer Period for Commission Action on Proposed Rule Change To Add Rules Related to the Clearing of Emerging Markets Sovereign Index Credit Default Swaps May 29, 2012. On April 3, 2012, ICE Clear Credit (``ICC'') filed with...

  16. 76 FR 55984 - Self-Regulatory Organizations; ICE Clear Credit LLC; Notice of Filing of Proposed Rule Change To...

    Science.gov (United States)

    2011-09-09

    ... clear additional credit default swap (``CDS'') contracts. Specifically, ICC is proposing to amend... COMMISSION Self-Regulatory Organizations; ICE Clear Credit LLC; Notice of Filing of Proposed Rule Change To Add Rules Related to the Clearing of Emerging Markets Sovereigns September 2, 2011. Pursuant...

  17. 78 FR 32287 - Self-Regulatory Organizations; ICE Clear Europe Limited; Notice of Filing of Proposed Rule Change...

    Science.gov (United States)

    2013-05-29

    ... United States. ICE Clear Europe is recognized as an interbank payment system by the Bank of England under... COMMISSION Self-Regulatory Organizations; ICE Clear Europe Limited; Notice of Filing of Proposed Rule Change...\\ and Rule 19b-4 thereunder \\2\\ notice is hereby given that on May 13, 2013, ICE Clear Europe...

  18. 77 FR 27255 - Self-Regulatory Organizations; ICE Clear Credit LLC; Order Approving Proposed Rule Change To...

    Science.gov (United States)

    2012-05-09

    ... This rule change permits ICC to make two modifications to its risk model for clearing credit default... COMMISSION Self-Regulatory Organizations; ICE Clear Credit LLC; Order Approving Proposed Rule Change To Reduce the Current Level of Risk Mutualization Among Clearing Participants and To Modify the...

  19. 77 FR 24546 - Self-Regulatory Organizations; ICE Clear Credit LLC; Order Approving Proposed Rule To Provide...

    Science.gov (United States)

    2012-04-24

    ... Treasuries.\\3\\ \\3\\ ICC applies haircuts to US Treasuries to mitigate liquidity risk. The haircuts as of April... initial margin-related liquidity requirements for client-related positions cleared in a clearing..._Clear_Credit_Collateral_Management.pdf ). The ICC rules currently provide that for all accounts at...

  20. Uncertainties of parameterized near-surface downward longwave and clear-sky direct radiation

    Directory of Open Access Journals (Sweden)

    S. Gubler

    2012-01-01

    Full Text Available As many environmental models rely on simulating the energy balance at the Earth's surface based on parameterized radiative fluxes, knowledge of the inherent uncertainties is important. In this study we evaluate one parameterization of clear-sky incoming shortwave radiation (SDR and diverse parameterizations of clear-sky and all-sky incoming longwave radiation (LDR. In a first step, the clear-sky global SDR is estimated based measured input variables and mean parameter values for hourly time steps during the year 1996 to 2008, and validated using the high quality measurements of seven Alpine Surface Radiation Budget (ASRB stations in Switzerland covering different elevations. Then, twelve clear-sky LDR parameterizations are fitted to the ASRB measurements. One of the best performing LDR parameterizations is chosen to estimate the all-sky LDR based on cloud transmissivity. Cloud transmissivity is estimated using measured and modeled global SDR during daytime. For the night, the performance of several interpolation methods is evaluated.

    Input variable and parameter uncertainties are assigned to estimate the total output uncertainty of the mentioned models, resulting in a mean relative uncertainty of 10% for the clear-sky direct, 15% for diffuse and 2.5% for global SDR, and 2.5% for the fitted all-sky LDR. Further, a function representing the uncertainty in dependence of the radiation is assigned for each model. Validation of the model outputs shows that direct SDR is underestimated (the mean error (ME is around −33 W m−2, while diffuse radiation is overestimated (ME around 19 W m−2. The root mean squared error (RMSE scatters around 60 W m−2 for direct, and 40 W m−2 for diffuse SDR. The best behaviour is found, due to the compensating effects of direct and diffuse SDR, for global SDR with MEs around −13 W m−2 and RMSEs around 40 W m−2. The ME of the fitted all

  1. Assessment of CCRS Cloud Detection Algorithm CLEAR Using AVHRR and MODIS Observations

    Science.gov (United States)

    Khlopenkov, K.; Trishchenko, A.

    2005-12-01

    The cloud/clear-sky detection algorithm CLEAR (CLoud Estimation using Aggregated Rating index) has been developed at the Canada Centre for Remote Sensing (CCRS) for the processing of the historical Advanced Very High Resolution Radiometer (AVHRR) observations made from the National Oceanic Atmospheric Administration satellites NOAA-6 to NOAA-17. The algorithm employs observations from 5 AVHRR channels and temperature fields from the North America Regional Reanalysis (NARR). The unique feature of the scene identification algorithm is the incorporation of several tests to produce an aggregated effective cloudiness index. This aggregated index has better reliability than a simple sequence of separate tests and allows for a distinction between the different levels of cloudiness. Other features of the algorithm are the dynamic correction for the sun glint for water pixels, the generation of snow/ice maps for cloud-free and thin-cloud pixels, and the calculation of a cloud shadow mask. The algorithm is implemented to operate for daytime and nighttime scenes during snow-free and snow seasons, over water and land areas. An assessment of the algorithm performance was conducted using supervised cloud/snow classification employing the Maximum Likelihood Classifier (MLC) routine available as a part of the multispectral analysis package of the Geomatica system (PCI Geomatics 2003). Comparison has been done for 12 scenes that covered Canada and US mid-latitude and polar regions and represented various seasons. Comparison showed very good consistency between automated processing using CLEAR scheme and the results of supervised classification. The agreement in the cloud detection was in the range of 89 percent to 91 percent for the summer scenes and around 84 percent to 88 percent for the winter. The consistency in the snow identification varied from 86 percent in winter to 94 percent during the warm season. The CLEAR algorithm has been also tuned to MODIS channels and applied for

  2. The theory of“clearing stagnated fire”%论“火郁发之”

    Institute of Scientific and Technical Information of China (English)

    齐文升

    2015-01-01

    “火郁发之”,语出《内经》,后之贤哲,多所发明。“郁”为病理,喻闭塞之意;“发”乃治则,含透散之旨。“火郁发之”是言火热之邪郁闭于内,不可单施苦寒直折,尤当透散以发之。仲景开“火郁发之”之先河,河间以为表里诸热证皆可归于阳气怫郁,东垣独重脾胃,内伤之病皆由脾胃而始,阳气抑遏脾土,清气不得升发。余以为,阳气以动为常,以行为用,盖当今之世,工业污染,农烟似霭;人处华栋,冬如暖夏,夏似凉冬,天地交济既失;人复生息失慎,焦虑紧张,激怒愤懑,气血常悖于内,渐至郁怫生火,郁火暗生,故治必内安其心,外适天地,天地人以位,方可身安立命,远疾疢矣。故医也者,顺天之时,测气之偏,顺气开结,引路去邪,从火之性,发火之郁。谨候气宜,无失病机,谨道如法,长有天命。%The theory of “clearing stagnated fire”is firstly written in Inner Canon of Huangdi.The later generation who are wise and able give different explanations. Stagnation is pathological, meaning blocking.Clearing is therapeutic principle, meaning clarity and let out.Clearing stagnated fire means pathogenic fire and heat are blocked in the body, treatment could not be carried out with bitter-cold herbs, and clear and divulge herbs is preferred.ZHANG Zhongjing is the first person who started using the theory of clearing stagnated fire.LIU Hejian attributes the heat syndrome from exterior to interior to stagnated yang qi.LI Dongyuan attaches importance to spleen and stomach, and believes that internal diseases are originated from spleen and stomach, yang qi restralns spleen which stops the ascending and dredging of clear qi.It is considered by the author that yang qi moves regularly, and works when circulating.In modern society, the industrial pollution is severe, and the smoke is extremely heavy;People lives in

  3. Uncertainties of parameterized surface downward clear-sky shortwave and all-sky longwave radiation.

    Directory of Open Access Journals (Sweden)

    S. Gubler

    2012-06-01

    Full Text Available As many environmental models rely on simulating the energy balance at the Earth's surface based on parameterized radiative fluxes, knowledge of the inherent model uncertainties is important. In this study we evaluate one parameterization of clear-sky direct, diffuse and global shortwave downward radiation (SDR and diverse parameterizations of clear-sky and all-sky longwave downward radiation (LDR. In a first step, SDR is estimated based on measured input variables and estimated atmospheric parameters for hourly time steps during the years 1996 to 2008. Model behaviour is validated using the high quality measurements of six Alpine Surface Radiation Budget (ASRB stations in Switzerland covering different elevations, and measurements of the Swiss Alpine Climate Radiation Monitoring network (SACRaM in Payerne. In a next step, twelve clear-sky LDR parameterizations are calibrated using the ASRB measurements. One of the best performing parameterizations is elected to estimate all-sky LDR, where cloud transmissivity is estimated using measured and modeled global SDR during daytime. In a last step, the performance of several interpolation methods is evaluated to determine the cloud transmissivity in the night.

    We show that clear-sky direct, diffuse and global SDR is adequately represented by the model when using measurements of the atmospheric parameters precipitable water and aerosol content at Payerne. If the atmospheric parameters are estimated and used as a fix value, the relative mean bias deviance (MBD and the relative root mean squared deviance (RMSD of the clear-sky global SDR scatter between between −2 and 5%, and 7 and 13% within the six locations. The small errors in clear-sky global SDR can be attributed to compensating effects of modeled direct and diffuse SDR since an overestimation of aerosol content in the atmosphere results in underestimating the direct, but overestimating the diffuse SDR. Calibration of LDR parameterizations

  4. Sediment CO2 efflux from cleared and intact temperate mangroves and tidal flats

    Science.gov (United States)

    Bulmer, R. H.; Schwendenmann, L.; Lundquist, C. J.

    2015-02-01

    Temperate mangroves in Southern Australia and New Zealand have been increasing in area over the past 50 years, whereas tropical mangroves have declined by 30-50% over a similar time frame. Tropical mangroves are understood to be an important carbon sink and carbon dioxide (CO2) emissions following clearance are estimated to be comparable or greater than CO2 emissions following the clearance of many terrestrial forest systems. Recreational and amenity values or perceived loss of other estuarine habitats due to expanding temperate mangrove forests have resulted in clearing of temperate mangroves. In this study, we investigated the impact of temperate mangrove clearance on CO2 efflux from the sediment to the atmosphere along with a range of other biotic and abiotic factors. Significantly higher CO2 efflux rates were measured in cleared (1.34 ± 0.46 μmol m2 s-1) and intact mangrove sites (2.31 ± 0.72 μmol m2 s-1) than in tidal flats (-0.23 ± 0.27 μmol m2 s-1). Site and sediment characteristics such as sediment carbon and nitrogen concentration, chlorophyll α concentration, grain size, mangrove height, macrofaunal abundance, sediment temperature and moisture were strongly correlated with sediment CO2 efflux. Our results suggest that carbon stored within temperate mangrove sediment is released over a period of years to decades after mangrove clearance. CO2 efflux from intact and cleared temperate mangroves was found to be comparable to rates observed in the tropics. Disturbance of the surface biofilm resulted in elevated CO2 efflux across all habitats, suggesting the important role of surface biofilm communities in mediating CO2 efflux.

  5. A clear cell adenocarcinoma of the gallbladder with hepatoid differentiation: case report and review of literature

    Directory of Open Access Journals (Sweden)

    Zhang C

    2016-09-01

    Full Text Available Chengsheng Zhang,1,2 Wei Zhang,1,2 Dianbin Mu,1 Xuetao Shi,1 Lei Zhao1,2 1Department of Hepatobiliary Surgery, Shandong Cancer Hospital affiliated to Shandong University, Shandong Academy of Medical Science, 2School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong Province, People’s Republic of China Abstract: An 80-year-old male was referred to our department for a gallbladder mass. He denied any history of alcohol consumption or cholecystitis and smoking. Hepatitis B surface antigen test and antihepatitis C antibody test were found to be negative. Serum carbohydrate antigen 19-9 (CA19-9 and carcinoembryonic antigen were elevated (CA19-9 was 59.92 U/mL and carcinoembryonic antigen was 12.64 ng/mL, whereas alpha-fetoprotein was below the normal limit (2.46 ng/mL. Computed tomography scan revealed a solid mass with measurements of 4.6×5.6×7.1 cm, which nearly filled the whole gallbladder space. Radical cholecystectomy, including segments IV B and V of the liver and lymphadenectomy, was performed. The neoplasm in gallbladder was completely resected, and the patient obtained a negative margin. Histological and immunohistochemical profile suggested a clear cell adenocarcinoma of the gallbladder with hepatoid differentiation. After reviewing the literature, we reported that this case is the first identified case of cell adenocarcinoma of the gallbladder with extensive hepatoid differentiation. However, clinical features of clear cell adenocarcinoma with hepatoid differentiation remain unclear due to the extremely rare incidence. There was no indication of adjuvant chemotherapy and no literature has been reported on the application of chemotherapy. This case showed a promising clinical outcome after curative resection, which indicated that surgical treatment could be potentially considered for suitable patients. Keywords: gallbladder, clear cell adenocarcinoma, hepatoid differentiation 

  6. Final Radiological Assessment of External Exposure for CLEAR-Line Americium Recovery Operations

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Adam C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Belooussova, Olga N. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hetrick, Lucas Duane [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2014-11-12

    Los Alamos National Laboratory is currently planning to implement an americium recovery program. The americium, ordinarily isotopically pure 241Am, would be extracted from existing Pu materials, converted to an oxide and shipped to support fabrication of americium oxide-beryllium neutron sources. These operations would occur in the currently proposed Chloride Extraction and Actinide Recovery (CLEAR) line of glove boxes. This glove box line would be collocated with the currently-operational Experimental Chloride Extraction Line (EXCEL). The focus of this document is to provide an in-depth assessment of the currently planned radiation protection measures and to determine whether or not further design work is required to satisfy design-goal and ALARA requirements. Further, this document presents a history of americium recovery operations in the Department of Energy and high-level descriptions of the CLEAR line operations to provide a basis of comparison. Under the working assumptions adopted by this study, it was found that the evaluated design appears to mitigate doses to a level that satisfies the ALARA-in-design requirements of 10 CFR 835 as implemented by the Los Alamos National Laboratory procedure P121. The analyses indicate that extremity doses would also meet design requirements. Dose-rate calculations were performed using the radiation transport code MCNP5 and doses were estimated using a time-motion study developed in consort with the subject matter expert. A copy of this report and all supporting documentation are located on the Radiological Engineering server at Y:\\Rad Engineering\\2013 PROJECTS\\TA-55 Clear Line.

  7. Clear cell variant of diffuse large B-cell lymphoma: a case report

    Directory of Open Access Journals (Sweden)

    Sahatciu-Meka Vjollca

    2011-05-01

    Full Text Available Abstract Introduction Diffuse large B-cell lymphoma is a diffuse proliferation of large neoplastic B lymphoid cells with a nuclear size equal to or exceeding the normal macrophage nuclei. We report a case of a clear cell variant of diffuse large B-cell lymphoma involving a lymph node in the neck, which was clinically suspected of being metastatic carcinoma. Case presentation A 39-year-old Caucasian ethnic Albanian man from Kosovo presented with a rapidly enlarging lymph node in his neck, but he also disclosed B symptoms and fatigue. A cytological aspirate of the lymph node revealed pleomorphic features. Our patient underwent a cervical lymph node biopsy (large excision. The mass was homogeneously fish-flesh, pale white tissue replacing almost the whole structure of the lymph node. The lymph node biopsy showed a partial alveolar growth pattern, which raised clinical suspicion that it was an epithelial neoplasm. With regard to morphological and phenotypic features, we discovered large nodules in diffuse areas, comprising large cells with slightly irregular nuclei and clear cytoplasm admixed with a few mononuclear cells. In these areas, there was high mitotic activity, and in some areas there were macrophages with tangible bodies. Staining for cytokeratins was negative. These areas had the following phenotypes: cluster designation marker 20 (CD20 positive, B-cell lymphoma (Bcl-2-positive, Bcl-6-, CD5-, CD3-, CD21+ (in alveolar patterns, prostate-specific antigen-negative, human melanoma black marker 45-negative, melanoma marker-negative, cytokeratin-7-negative and multiple myeloma marker 1-positive in about 30% of cells, and exhibited a high proliferation index marker (Ki-67, 80%. Conclusion According to the immunohistochemical findings, we concluded that this patient has a clear cell variant of diffuse large B-cell lymphoma of activated cell type, post-germinal center cell origin. Our patient is undergoing R-CHOP chemotherapy treatment.

  8. TurbEFA: an interdisciplinary effort to investigate the turbulent flow across a forest clearing

    Directory of Open Access Journals (Sweden)

    Ronald Queck

    2015-01-01

    Full Text Available It is assumed that the description of the exchange processes between heterogeneous natural surfaces and the atmosphere within turbulence closure models is mainly limited by a realistic three-dimensional (3D representation of the vegetation architecture. Within this contribution we present a method to record the 3D vegetation structure and to use this information to derive model parameters that are suitable for numerical flow models. A mixed conifer forest stand around a clearing was scanned and represented by a dense 3D point cloud applying a terrestrial laser scanner. Thus, the plant area density (PAD with a resolution of one cubic meter was provided for analysis and for numerical simulations. Multi-level high-frequency wind velocity measurements were recorded simultaneously by 27 ultrasonic anemometers on 4 towers for a period of one year. The relationship between wind speed, Reynolds stress and PAD was investigated and a parametrization of the drag coefficient CD$C_D$ by the PAD is suggested. The derived 3D vegetation model and a simpler model (based on classical forest assessments of the site were applied in a boundary layer model (BLM and in large-eddy simulations (LES. The spatial development of the turbulent flow over the clearing is further demonstrated by the results of a wind tunnel experiment. The project showed, that the simulation results were improved significantly by the usage of realistic vegetation models. 3D simulations are necessary to depict the influence of heterogeneous canopies on the turbulent flow. Whereas we found limits for the mapping of the vegetation structure within the wind tunnel, there is a considerable potential for numerical simulations. The field measurements and the LES gave new insight into the turbulent flow in the vicinity and across the clearing. The results show that the zones of intensive turbulence development can not be restricted to the locations found in previous studies with more idealized

  9. Retrieving Clear-Sky Surface Skin Temperature for Numerical Weather Prediction Applications from Geostationary Satellite Data

    Directory of Open Access Journals (Sweden)

    Baojuan Shan

    2013-01-01

    Full Text Available Atmospheric models rely on high-accuracy, high-resolution initial radiometric and surface conditions for better short-term meteorological forecasts, as well as improved evaluation of global climate models. Remote sensing of the Earth’s energy budget, particularly with instruments flown on geostationary satellites, allows for near-real-time evaluation of cloud and surface radiation properties. The persistence and coverage of geostationary remote sensing instruments grant the frequent retrieval of near-instantaneous quasi-global skin temperature. Among other cloud and clear-sky retrieval parameters, NASA Langley provides a non-polar, high-resolution land and ocean skin temperature dataset for atmospheric modelers by applying an inverted correlated k-distribution method to clear-pixel values of top-of-atmosphere infrared temperature. The present paper shows that this method yields clear-sky skin temperature values that are, for the most part, within 2 K of measurements from ground-site instruments, like the Southern Great Plains Atmospheric Radiation Measurement (ARM Infrared Thermometer and the National Climatic Data Center Apogee Precision Infrared Thermocouple Sensor. The level of accuracy relative to the ARM site is comparable to that of the Moderate-resolution Imaging Spectroradiometer (MODIS with the benefit of an increased number of daily measurements without added bias or increased error. Additionally, matched comparisons of the high-resolution skin temperature product with MODIS land surface temperature reveal a level of accuracy well within 1 K for both day and night. This confidence will help in characterizing the diurnal and seasonal biases and root-mean-square differences between the retrievals and modeled values from the NASA Goddard Earth Observing System Version 5 (GEOS-5 in preparation for assimilation of the retrievals into GEOS-5. Modelers should find the immediate availability and broad coverage of these skin temperature

  10. Clear-sky Atmospheric Radiative Transfer: A Model Intercomparison for Shortwave Irradiances

    Science.gov (United States)

    Wang, P.; Knap, W. H.; Munneke, P. Kuipers; Stammes, P.

    2009-03-01

    This study consists of an intercomparison of clear-sky shortwave irradiances calculated by the Doubling Adding model of KNMI (DAK) and the Simple Model of the Atmospheric Radiative Transfer of Sunshine (SMARTS). The DAK and SMARTS models are run with identical input (state profiles, water vapour, ozone, aerosols, etc.) and the differences between the models are examined in terms of broadband shortwave irradiances as a function of solar zenith angle. The DAK and SMARTS models agree very well. For a pure Rayleigh atmosphere the differences in the irradiances are less than 5 W/m2. For cases with aerosols the differences of the irradiances are within 10 W/m2.

  11. The clinical and imaging features of clear cell meningioma in ten cases

    Directory of Open Access Journals (Sweden)

    ZHAO Guang-zuo

    2012-10-01

    Full Text Available Objective To investigate the clinical features and imaging findings of intracranial clear cell meningioma. Methods The clinical data were reviewed, including presentation, imaging and prognosis of 10 patients suffered from intracranial clear cell meningioma for 2 months-7 years and underwent surgical treatment. The patients included five males and five females with the age from nine to sixty-two years old (mean 35.43. The tumors were located at cerebellopontine angle (CPA zone (n = 5, parietal lobe (n = 1, tuberculum sella (n = 1, jugular foramen (n = 1, tentorium of cerebellum (n = 1 or lateral cerebral ventricle (n = 1. The initial symptoms included headache (n = 4, gait disturbance (n = 2, hearing loss (n = 2, vision loss (n = 1 and bucking (n = 1 which were associated with the mass locations. Results CT (n = 8 and MRI (n = 10 of 10 patients were retrospectively reviewed. CT findings of the lesions presented with hyperdensity (n = 6, isodensity (n = 1, or isodensity with hyperdensity (n = 1. MRI T1WI showed isointensity (n = 4, hypointensity with isointensity (n = 4 or hyperintensity (n = 2, whereas T2WI isointensity with hyperintensity (n = 7, presented hypointensity (n = 1, isointensity (n = 1, or hyperintensity (n = 1. On gadolinium-enhanced T1WI, moderate enhancement was seen in 8 lesions and marked enhancement was seen in 2 lesions. In initial CT scanning peritumoral edema was found in 7 cases, dural tail sign in 5 cases, cysts in 7 cases, calcification in 3 cases, periosteal proliferation in 1 case and bone destruction in 5 cases. Seven patients underwent complete resection and 3 underwent subtotal resection. Follow-up period was 11-120 months. Recurrence occurred in 5 patients. The mean recurrence time was 55.62 months. Conclusion Clear cell meningioma is a rare meningioma and often occurs in young persons without significant difference in sex. The CPA zone is the most affected area. The prognosis is closely related to the extent of

  12. A method for quantitative analysis of aquatic humic substances in clear water based on carbon concentration.

    Science.gov (United States)

    Tsuda, Kumiko; Takata, Akihiro; Shirai, Hidekado; Kozaki, Katsutoshi; Fujitake, Nobuhide

    2012-01-01

    Aquatic humic substances (AHSs) are major constituents of dissolved organic matter (DOM) in freshwater, where they perform a number of important ecological and geochemical functions, yet no method exists for quantifying all AHSs. We have developed a method for the quantitative analysis of AHSs based on their carbon concentration. Our approach includes: (1) the development of techniques for clear-water samples with low AHS concentrations, which normally complicate quantification; (2) avoiding carbon contamination in the laboratory; and (3) optimizing the AHS adsorption conditions.

  13. Collaborative effects of wavefront shaping and optical clearing agent in optical coherence tomography

    CERN Document Server

    Yu, Hyeonseung; Jo, YoungJu; Lee, KyeoReh; Tuchin, Valery V; Jeong, Yong; Park, YongKeun

    2016-01-01

    We demonstrate that simultaneous application of optical clearing agents (OCAs) and complex wavefront shaping in optical coherence tomography (OCT) can provide significant enhancement of the penetration depth and imaging quality. OCA reduces optical inhomogeneity of a highly scattering sample, and the wavefront shaping of illumination light controls multiple scattering, resulting in an enhancement of the penetration depth and signal-to-noise ratio. A tissue phantom study shows that concurrent applications of OCA and wavefront shaping successfully operate in OCT imaging. The penetration depth enhancement is further demonstrated for ex vivo mouse ears, revealing hidden structures inaccessible with conventional OCT imaging.

  14. Clear-PEM: A PET imaging system dedicated to breast cancer diagnostics

    CERN Document Server

    Abreu, M C; Albuquerque, E; Almeida, F G; Almeida, P; Amaral, P; Auffray, Etiennette; Bento, P; Bruyndonckx, P; Bugalho, R; Carriço, B; Cordeiro, H; Ferreira, M; Ferreira, N C; Gonçalves, F; Lecoq, Paul; Leong, C; Lopes, F; Lousã, P; Luyten, J; Martins, M V; Matela, N; Rato-Mendes, P; Moura, R; Nobre, J; Oliveira, N; Ortigão, C; Peralta, L; Rego, J; Ribeiro, R; Rodrigues, P; Santos, A I; Silva, J C; Silva, M M; Tavernier, Stefaan; Teixeira, I C; Texeira, J P; Trindade, A; Trummer, Julia; Varela, J

    2007-01-01

    The Clear-PEM scanner for positron emission mammography under development is described. The detector is based on pixelized LYSO crystals optically coupled to avalanche photodiodes and readout by a fast low-noise electronic system. A dedicated digital trigger (TGR) and data acquisition (DAQ) system is used for on-line selection of coincidence events with high efficiency, large bandwidth and small dead-time. A specialized gantry allows to perform exams of the breast and of the axilla. In this paper we present results of the measurement of detector modules that integrate the system under construction as well as the imaging performance estimated from Monte Carlo simulated data.

  15. [Clear-cell sarcoma of the kidney: about a paediatric case].

    Science.gov (United States)

    Namaoui, R Y; Castex, M P; Vial, J; Galinier, P; Rubie, H; Laprie Mazieres, A; Le Mandat, A; Brousset, P; Delsol-Tahou, M

    2010-06-01

    Clear-cell sarcoma of the kidney (CCSK) is a rare malignant tumor of childhood, known for its aggressiveness, its tendency to recurrence and to metastasis to bone. We report an observation of a child of 48 months carrying a large abdominal mass. The diagnosis of the SCCR was made on biopsy, since imaging remained uncertain as to the renal origin of the mass. Indeed, our observation underlines the difficulty of its diagnosis. Excepting the morphological aspect, there is no criterion for its recognition. Its prognosis has been improved by the new treatments.

  16. Skull Base Clear Cell Carcinoma, Metastasis of Renal Primary Tumor: A Case Report and Literature Review

    Directory of Open Access Journals (Sweden)

    Ilson Sepúlveda

    2013-08-01

    Full Text Available We report on a patient who presented with cranial nerve VI bilateral paresis, absence of pharyngeal reflex, dysarthria, right tongue deviation, and right facial paralysis. Imaging studies showed an expansive process in the cranial base with clivus and petrous apex osteolysis. A biopsy confirmed the presence of clear cell adenocarcinoma and suspicion of renal tumor metastases. Abdominal imaging studies revealed a mass in the right kidney. Consequently, radiotherapy was performed, and the patient was enrolled in a palliative care and pain control program.

  17. Impact of Renewable Energy Forecast Imperfections on Market-Clearing Outcomes

    DEFF Research Database (Denmark)

    Ordoudis, Christos; Pinson, Pierre

    2016-01-01

    . Hence, innovative market structures have been proposed to cope with the uncertainty introduced. Nonetheless, the quality of wind power forecasts may affect the market outcome due to their inaccuracy. For this reason, a framework is proposed to examine market-clearing algorithms, both deterministic...... and stochastic approaches, under imperfect wind power forecasts in order to quantify their influence on the market outcome. Results show that mean value mismatch between “estimated” and “realized” distributions has the highest impact on total system cost. Finally, it is examined if cost recovery for market...... players is guaranteed in the presence of inaccurate wind power forecasts....

  18. Single clear corneal incision for glaucoma drainage device shortening in pediatric glaucoma.

    Science.gov (United States)

    Radke, Phillip M; Bitrian, Elena; Grajewski, Alana L

    2016-06-01

    Glaucoma drainage devices are commonly used for management of glaucoma in adults and children. With time, the position of the tube can change and cause damage such as corneal scarring, iris or lens contact, and uveitis. Most of these problems can be improved with tube shortening and/or excision of adherent iris or fibrous tissue. We describe a surgical technique that uses a single clear corneal incision to externalize and trim the shunt in pediatric patients. The technique has a short surgical. We review the indications and outcomes for this procedure in 13 eyes of 12 children who required shunt revision.

  19. Clear-cell carcinoma of the lung metastatic to the hamate: a case report.

    Science.gov (United States)

    Nissenbaum, M; Kutz, J E; Lister, G D

    1978-01-01

    Metastatic lesions of the hand are uncommon. A report of a solitary metastasis to the hamate seems not to have appeared previously in the literature. A 46-year-old factory worker presented a rare tumor, clear-cell carcinom of the lung, metastasizing to an unusual location, the hamate. The symptoms simulated sympathetic dystrophy and diagnosis was delayed because of the late appearance of radiographic changes over 6 months after symptoms first appeared. Early bone scanning in patients with chronic pain may provide useful information prior to the appearance of X-ray changes.

  20. Chronic lymphocytic lymphoma and concomitant renal cell carcinoma (Clear Cell Type: Review of the literature

    Directory of Open Access Journals (Sweden)

    Burak Uz

    2016-01-01

    Full Text Available In the present report, a 73 years-old male patient who developed clear cell type renal cell carcinoma (RCC 5 years after the diagnosis of chronic lymphocytic lymphoma (CLL and plausible explanations for this association were discussed by the authors. The incidence of CLL and RCC occurring in the same patient is higher than that expected in the general population. Various explicative hypotheses of this concurrence include treatment-related development of a second malignancy, immunomodulatory mechanisms, viral aetiology, cytokine (interleukin 6 release from a tumor, and common genetic mutations. Further investigations are warranted.

  1. Clear-PEM: A PET imaging system dedicated to breast cancer diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Abreu, M.C. [LIP, Lab. de Instrumentacao e Fisica Exp. Particulas (Portugal); Aguiar, D. [INESC-ID and INOV, Lisbon (Portugal); Albuquerque, E. [INEGI Inst. Eng. Mecanica Gestao Industrial, Porto (Portugal)] (and others)

    2007-02-01

    The Clear-PEM scanner for positron emission mammography under development is described. The detector is based on pixelized LYSO crystals optically coupled to avalanche photodiodes and readout by a fast low-noise electronic system. A dedicated digital trigger (TGR) and data acquisition (DAQ) system is used for on-line selection of coincidence events with high efficiency, large bandwidth and small dead-time. A specialized gantry allows to perform exams of the breast and of the axilla. In this paper we present results of the measurement of detector modules that integrate the system under construction as well as the imaging performance estimated from Monte Carlo simulated data.

  2. Clear air boundary layer spaced antenna wind measurement with the Multiple Antenna Profiler (MAPR

    Directory of Open Access Journals (Sweden)

    S. A. Cohn

    Full Text Available Spaced antenna (SA wind measurement techniques are applied to Multiple Antenna Profiler (MAPR data to evaluate its performance in clear air conditions. MAPR is a multiple antenna 915 MHz wind profiler developed at the National Center for Atmospheric Research (NCAR and described in Cohn et al. (1997, designed to make high resolution wind measurements. Previous reported measurements with MAPR were restricted to precipitation because of low signal to noise (SNR and signal to ground-clutter (SCR ratios. By using a standard pulse-coding technique and upgrading the profiler control software, increases in average power and SNR were achieved, making routine measurements in clear air possible. Comparison of winds measured by MAPR and by a sonic anemometer on a nearby 300 m tower show correlation coefficients in the range of R2 = 0.75 – 0.80, and an average absolute error of ~ 1.4 m s - 1 . This compares favorably with the agreement typically found in wind profiler comparisons. We also consider the use of the parameter ah , which is related to the value of the cross-correlation function at its zero crossing. This parameter is a data quality indicator and possibly a key component in a ground clutter removal technique.

    Key words. Meteorology and atmospheric dynamics (mesoscale meteorology; instruments and techniques – Radio science (remote sensing

  3. HST hot-Jupiter transmission spectral survey: Clear skies for cool Saturn WASP-39b

    CERN Document Server

    Fischer, Patrick D; Sing, David K; Henry, Gregory W; Williamson, Michael W; Fortney, Jonathan J; Burrows, Adam S; Kataria, Tiffany; Nikolov, Nikolay; Showman, Adam P; Ballester, Gilda E; Désert, Jean-Michel; Aigrain, Suzanne; Deming, Drake; Etangs, Alain Lecavelier des; Vidal-Madjar, Alfred

    2016-01-01

    We present HST STIS optical transmission spectroscopy of the cool (approximately 1116 K) Saturn-mass exoplanet WASP-39b from 0.29-1.025 micron, along with complementary transit observations from Spitzer IRAC at 3.6 and 4.5 micron. The low density and large atmospheric pressure scale height of WASP-39b make it particularly amenable to atmospheric characterization using this technique. We detect a Rayleigh scattering slope as well as sodium and potassium absorption features; this is the first exoplanet in which both alkali features are clearly detected with the extended wings predicted by cloud-free atmosphere models. The full transmission spectrum is well matched by a clear, H2- dominated atmosphere or one containing a weak contribution from haze, in good agreement with the preliminary reduction of these data presented in Sing et al. (2016). WASP-39b is predicted to have a pressure-temperature profile comparable to that of HD 189733b and WASP-6b, making it one of the coolest transiting gas giants observed in o...

  4. Patient perceptions of integrated care: confused by the term, clear on the concept

    Directory of Open Access Journals (Sweden)

    Kara Odom Walker

    2013-03-01

    Full Text Available Purpose: Health care reform in the United States has introduced terms such as “the patient-centered medical home” and “integrated care” that are often unclear and unfamiliar to patients. This study explored patient experiences with the functional domains of integrated care. Theory and methods: Patients first wrote their definitions of integrated care and then participated in focus group discussions about their experiences with the health care system. Transcripts were analyzed for thematic content. Results: Forty-four patients participated in one of seven focus groups in San Francisco, CA in English and Spanish. Many patients were not clear about the meaning of the term integrated care. However, patients described experiences largely reflected in an existing conceptual model of integrated care and the importance of coordination within and across teams and with community resources, continuity and sharing of information, and patient engagement. Patients with high medical needs described the ubiquitous challenges they faced in experiencing coordinated care. Conclusions: Patients may not understand the term integrated care but are relatively clear on what the concept of integrated care entails and support its successful implementation. Patients and their families are at the center of integrated care, and health systems need to support and empower them to successfully navigate the medical neighborhood.

  5. Application of the Lighthill-Ford Theory of Spontaneous Imbalance to Clear-Air Turbulence Forecasting

    Science.gov (United States)

    Williams, Pd; Knox, Ja; McCann, Dw

    2009-09-01

    A new method of clear-air turbulence (CAT) forecasting based on the Lighthill-Ford theory of spontaneous imbalance and emission of inertia-gravity waves has been derived and applied on episodic and seasonal time scales. A scale analysis of this shallow-water theory for midlatitude synoptic-scale flows identifies advection of relative vorticity as the leading-order source term. Examination of leading- and second-order terms elucidates previous, more empirically inspired CAT forecast diagnostics. Application of the Lighthill-Ford theory to the Upper Mississippi and Ohio Valleys CAT outbreak of 9 March 2006 results in good agreement with pilot reports of turbulence. Application of Lighthill-Ford theory to CAT forecasting for the 3 November 2005-26 March 2006 period using 1-h forecasts of the Rapid Update Cycle (RUC) 2 1500 UTC model run leads to superior forecasts compared to the current operational version of the Graphical Turbulence Guidance (GTG1) algorithm, the most skillful operational CAT forecasting method in existence. The results suggest that major improvements in CAT forecasting could result if the methods presented herein become operational. Reference Knox, J.A., D.W. McCann, and P.D. Williams, 2008: Application of the Lighthill-Ford Theory of Spontaneous Imbalance to Clear-Air Turbulence Forecasting. J. Atmos. Sci., 65, 3292-3304.

  6. Piloted "Well Clear" Performance Evaluation of Detect-and-Avoid Systems with Suggestive Guidance

    Science.gov (United States)

    Mueller, Eric R.; Santiago, Confesor; Watza, Spencer

    2016-01-01

    This study evaluated the performance of four prototype unmanned aircraft detect-and-avoid (DAA) display configurations, each with different informational elements driven by alerting and guidance algorithms. Sixteen unmanned aircraft pilots flew each combination of the display configurations, with half being given zero DAA surveillance sensor uncertainty and the other half experiencing errors that were comparable, and in some cases slightly better than, errors that were measured in DAA system flight tests. The displays that showed intruder alert information in altitude and heading bands had significantly fewer losses of well clear compared with alternative displays that lacked that information. This difference was significant from a statistical and practical perspective: those losses that did occur lasted for shorter periods and did not penetrate as far into the geometric "separation cylinder" as those in the non-banded displays. A modest level of DAA surveillance sensor uncertainty did not affect the proportion of losses of well clear or their severity. It is recommended that DAA traffic displays implement a band-type display in order to improve the safety of UAS operations in the National Airspace System. Finally, this report provides pilot response time distributions for responding to DAA alerts.

  7. Optical clearing of skin enhanced with hyaluronic acid for increased contrast of optoacoustic imaging

    Science.gov (United States)

    Liopo, Anton; Su, Richard; Tsyboulski, Dmitri A.; Oraevsky, Alexander A.

    2016-08-01

    Enhanced delivery of optical clearing agents (OCA) through skin may improve sensitivity of optical and optoacoustic (OA) methods of imaging, sensing, and monitoring. This report describes a two-step method for enhancement of light penetration through skin. Here, we demonstrate that topical application of hyaluronic acid (HA) improves skin penetration of hydrophilic and lipophilic OCA and thus enhances their performance. We examined the OC effect of 100% polyethylene and polypropylene glycols (PPGs) and their mixture after pretreatment by HA, and demonstrated significant increase in efficiency of light penetration through skin. Increased light transmission resulted in a significant increase of OA image contrast in vitro. Topical pretreatment of skin for about 30 min with 0.5% HA in aqueous solution offers effective delivery of low molecular weight OCA such as a mixture of PPG-425 and polyethylene glycol (PEG)-400. The developed approach of pretreatment by HA prior to application of clearing agents (PEG and PPG) resulted in a ˜47-fold increase in transmission of red and near-infrared light and significantly enhanced contrast of OA images.

  8. Preliminary juvenile Lost River and shortnose sucker investigations in Clear Lake, California--2011 pilot study summary

    Science.gov (United States)

    Burdick, Summer M.; Rasmussen, Josh

    2012-01-01

    Poor recruitment appears to limit the recovery of Lost River and shortnose sucker populations in Clear Lake Reservoir, California, but the cause is unknown. Adult suckers migrate up Willow Creek and its tributaries to spawn in some years, but low flow in Willow Creek may inhibit spawning migrations in other years. It is unclear whether spawning is successful, larvae survive, or juveniles persist to adulthood. Environmental variables associated with successful spawning or young-of-year survival have not been identified and early life history for these populations is poorly understood. The U.S. Geological Survey in cooperation with the U.S. Fish and Wildlife Service and Ruby Pipeline L.L.C. Corporation (El Paso, Tex.) initiated a study in 2011 to better understand juvenile sucker life history in Clear Lake Reservoir, and to identify constraints in the early life history that may limit recruitment to the adult spawning populations. This is a report on the 2011 pilot study for this project.

  9. Beat processing is pre-attentive for metrically simple rhythms with clear accents: an ERP study.

    Science.gov (United States)

    Bouwer, Fleur L; Van Zuijen, Titia L; Honing, Henkjan

    2014-01-01

    The perception of a regular beat is fundamental to music processing. Here we examine whether the detection of a regular beat is pre-attentive for metrically simple, acoustically varying stimuli using the mismatch negativity (MMN), an ERP response elicited by violations of acoustic regularity irrespective of whether subjects are attending to the stimuli. Both musicians and non-musicians were presented with a varying rhythm with a clear accent structure in which occasionally a sound was omitted. We compared the MMN response to the omission of identical sounds in different metrical positions. Most importantly, we found that omissions in strong metrical positions, on the beat, elicited higher amplitude MMN responses than omissions in weak metrical positions, not on the beat. This suggests that the detection of a beat is pre-attentive when highly beat inducing stimuli are used. No effects of musical expertise were found. Our results suggest that for metrically simple rhythms with clear accents beat processing does not require attention or musical expertise. In addition, we discuss how the use of acoustically varying stimuli may influence ERP results when studying beat processing.

  10. Beat processing is pre-attentive for metrically simple rhythms with clear accents: an ERP study.

    Directory of Open Access Journals (Sweden)

    Fleur L Bouwer

    Full Text Available The perception of a regular beat is fundamental to music processing. Here we examine whether the detection of a regular beat is pre-attentive for metrically simple, acoustically varying stimuli using the mismatch negativity (MMN, an ERP response elicited by violations of acoustic regularity irrespective of whether subjects are attending to the stimuli. Both musicians and non-musicians were presented with a varying rhythm with a clear accent structure in which occasionally a sound was omitted. We compared the MMN response to the omission of identical sounds in different metrical positions. Most importantly, we found that omissions in strong metrical positions, on the beat, elicited higher amplitude MMN responses than omissions in weak metrical positions, not on the beat. This suggests that the detection of a beat is pre-attentive when highly beat inducing stimuli are used. No effects of musical expertise were found. Our results suggest that for metrically simple rhythms with clear accents beat processing does not require attention or musical expertise. In addition, we discuss how the use of acoustically varying stimuli may influence ERP results when studying beat processing.

  11. The clear-sky greenhouse effect sensitivity to a sea surface temperature change

    Science.gov (United States)

    Duvel, J. PH.; Breon, F. M.

    1991-01-01

    The clear-sky greenhouse effect response to a sea surface temperature (SST or Ts) change is studied using outgoing clear-sky longwave radiation measurements from the Earth Radiation Budget Experiment. Considering geographical distributions for July 1987, the relation between the SST, the greenhouse effect (defined as the outgoing infrared flux trapped by atmospheric gases), and the precipitable water vapor content (W), estimated by the Special Sensor Microwave Imager, is analyzed first. A fairly linear relation between W and the normalized greenhouse effect g, is found. On the contrary, the SST dependence of both W and g exhibits nonlinearities with, especially, a large increase for SST above 25 C. This enhanced sensitivity of g and W can be interpreted in part by a corresponding large increase of atmospheric water vapor content related to the transition from subtropical dry regions to equatorial moist regions. Using two years of data (1985 and 1986), the normalized greenhouse effect sensitivity to the sea surface temperature is computed from the interannual variation of monthly mean values.

  12. Solar Spectral Irradiance under Clear and Cloudy Skies: Measurements and a Semiempirical Model.

    Science.gov (United States)

    Nann, Stefan; Riordan, Carol

    1991-04-01

    In a combined effort, the Centre for Solar Energy and Hydrogen Research in Germany and the Solar Energy Research Institute in the United States analyzed several thousand measurements of the solar spectral irradiance recorded at four sites. The goal was to develop a semiempirical model that describes the total solar spectral irradiance for clear and cloudy sky conditions based on readily available input data.To investigate how the spectral transmission of clouds deviates from an assumed neutral density filter, the measured spectra are compared with simulated clear-sky spectra. A correlation is established between the cloud thickness and the relatively higher transmission of clouds in the ultraviolet and blue region of the solar spectrum. Using this approach, a semiempirical model is proposed based solely on global and diffuse broadband irradiance measurements, precipitable water-vapor data, and the sun's position. The model, called SEDESI, is applied to calculate spectral irradiance in short time steps (30 or 60 minutes) that are needed for either the design and performance analysis of spectrally selective solar energy conversion systems or to predict daylight availability. The results are also applicable to current climate research areas such as validating radiative transfer codes.

  13. Unlikely remedy: fungicide clears infection from pathogenic fungus in larval southern leopard frogs (Lithobates sphenocephalus.

    Directory of Open Access Journals (Sweden)

    Shane M Hanlon

    Full Text Available Amphibians are often exposed to a wide variety of perturbations. Two of these, pesticides and pathogens, are linked to declines in both amphibian health and population viability. Many studies have examined the separate effects of such perturbations; however, few have examined the effects of simultaneous exposure of both to amphibians. In this study, we exposed larval southern leopard frog tadpoles (Lithobates sphenocephalus to the chytrid fungus Batrachochytrium dendrobatidis and the fungicide thiophanate-methyl (TM at 0.6 mg/L under laboratory conditions. The experiment was continued until all larvae completed metamorphosis or died. Overall, TM facilitated increases in tadpole mass and length. Additionally, individuals exposed to both TM and Bd were heavier and larger, compared to all other treatments. TM also cleared Bd in infected larvae. We conclude that TM affects larval anurans to facilitate growth and development while clearing Bd infection. Our findings highlight the need for more research into multiple perturbations, specifically pesticides and disease, to further promote amphibian heath.

  14. Component-Level Electronic-Assembly Repair (CLEAR) Synthetic Instrument Capabilities Assessment and Test Report

    Science.gov (United States)

    Oeftering, Richard C.; Bradish, Martin A.

    2011-01-01

    The role of synthetic instruments (SIs) for Component-Level Electronic-Assembly Repair (CLEAR) is to provide an external lower-level diagnostic and functional test capability beyond the built-in-test capabilities of spacecraft electronics. Built-in diagnostics can report faults and symptoms, but isolating the root cause and performing corrective action requires specialized instruments. Often a fault can be revealed by emulating the operation of external hardware. This implies complex hardware that is too massive to be accommodated in spacecraft. The SI strategy is aimed at minimizing complexity and mass by employing highly reconfigurable instruments that perform diagnostics and emulate external functions. In effect, SI can synthesize an instrument on demand. The SI architecture section of this document summarizes the result of a recent program diagnostic and test needs assessment based on the International Space Station. The SI architecture addresses operational issues such as minimizing crew time and crew skill level, and the SI data transactions between the crew and supporting ground engineering searching for the root cause and formulating corrective actions. SI technology is described within a teleoperations framework. The remaining sections describe a lab demonstration intended to show that a single SI circuit could synthesize an instrument in hardware and subsequently clear the hardware and synthesize a completely different instrument on demand. An analysis of the capabilities and limitations of commercially available SI hardware and programming tools is included. Future work in SI technology is also described.

  15. Effects of clear liquids on gastric volume and pH in healthy volunteers.

    Science.gov (United States)

    Shevde, K; Trivedi, N; Gross, M

    1991-04-01

    The effects of clear liquids on gastric volume and pH were examined in 30 healthy ASA physical status I volunteers. After overnight fasting, a Salem-sump nasogastric tube was inserted and gastric contents were removed for measurement of volume and pH. Gastric contents were then reinserted through the nasogastric tube into the stomach. The volunteers were randomly divided into three groups: group 1 (n = 10) received 240 mL water, group 2 (n = 10) received 240 mL coffee, and group 3 (n = 10) received 240 mL pulp-free orange juice. All liquids were administered orally. Gastric contents were then again aspirated, measured for volume and pH, and reinserted through the nasogastric tube every half hour until gastric volume was less than 25 mL. All volunteers had gastric volumes less than 25 mL with a slight decrease in pH within 2 h of orally taking one of the three 240-mL liquids. These data suggest that if patients have ingested a moderate amount of clear liquids it is safe to conduct general anesthesia after a 2-h fast in healthy surgical patients.

  16. Clear cell chondrosarcoma calcaneum - a case report and review of literature.

    Science.gov (United States)

    Nagmani, Singh; Rakesh, John; Aditya, Aggarwal; Sandeep, Patel; Arjun, R H H; Debasis, Gochhait

    2015-03-01

    Chondrosarcoma is the second most common primary bone malignancy accounting for 20-25% of all bone sarcomas. However chondrosarcoma of the foot is rare with just a handful of cases being described. Among the subtypes clear cell variant is the rarest and has never been documented in the foot. We present a rare case of clear cell chondrosarcoma of the calcaneum with multiple metastases that was treated at our institute. The patient was a 62-year old male who presented to us with pain and mass in the left hindfoot with difficulty in walking for 2 years and a discharging ulcer over the lateral aspect for 4 months. Radiography showed aggressive, destructive, lytic lesion in the calcaneum with cortical breach and soft tissue invasion. Bone scan and PET-CT revealed multiple bony metastases and lung metastasis. After initial biopsy, patient underwent below knee amputation and has been in remission since the last 18 months. Given the rarity of this tumor in the calcaneum, this report highlights the importance to consider the possibility of this tumor in the calcaneum as an early diagnosis; complete metastatic workup and expeditious management can thus significantly improve prognosis.

  17. Pharmacokinetics of reduced iso-α-acids in volunteers following clear bottled beer consumption.

    Science.gov (United States)

    Rodda, Luke N; Gerostamoulos, Dimitri; Drummer, Olaf H

    2015-05-01

    Reduced iso-α-acids (reduced IAA) consisting of the rho-, tetrahydro- and hexahydro-IAA groups (RIAA, TIAA and HIAA, respectively) are ingredient congeners specific to beer and generally found in clear and also occasionally green bottled beer. Concentrations of reduced IAA were determined in the blood and urine of five volunteers over 6h following the consumption of small volumes of beer containing each of the reduced IAA. The reduced IAA were absorbed and bioavailable with peak concentrations at 0.5h followed by a drop of generally fivefold by 2h. Preliminary pharmacokinetics of these compounds in humans shows relatively small inter-individual differences and an estimated short half-life varying between ∼38 and 46min for the three groups. Comparison of RIAA analyte ratios within the group indicate that some analytes eliminate relatively faster than others and the formation of metabolite products was observed. Preliminary urine analysis showed only unmodified RIAA analytes were detectable throughout 6h and suggests extensive phase I metabolism of TIAA and HIAA analytes. In authentic forensic casework where clear or green bottled beers are consumed, the identification of reduced IAA groups may provide a novel method to target ingredient congeners consistent with beer ingestion and suggest the type of beer consumed.

  18. Shrub resprouting response after fuel reduction treatments: comparison of prescribed burning, clearing and mastication.

    Science.gov (United States)

    Fernández, Cristina; Vega, José A; Fonturbel, Teresa

    2013-03-15

    Fuel reduction treatments are commonly used to reduce the risk of severe wildfire. However, more information about the effects on plant resprouting is needed to help land managers select the most appropriate treatment. To address this question, we evaluated the resprouting ability of five shrub species after the application of different types of fuel reduction methods (prescribed burning, clearing and mastication) in two contrasting shrubland areas in northern Spain. The shrub species were Erica australis, Pterospartum tridentatum and Halimium lasianthum spp. alyssoides, Ulex gallii and Erica cinerea. For most of the species under study (E. australis, P. tridentatum, H. lasianthum spp. alyssoides and U. gallii), neither plant mortality nor the number nor length of sprouted shoots per plant differed between treatments, although in E. cinerea the number of shoots was more negatively affected by prescribed burning than by clearing or mastication. The pre-treatment plant size did not affect plant mortality or plant resprouting response, suggesting that this parameter alone is not a good indicator of plant resprouting after fuel reduction treatments. Stem minimum diameter after treatments, a proxy of treatment severity, was not related to plant mortality, number or length of resprouted shoots. The duration of temperatures higher than 300 °C during burning in plant crown had a negative effect on the length of resprouted shoots, only in E. cinerea. The results show that fuel reduction treatments did not prevent shrub response in any case. Some reflections on the applicability of treatments are discussed.

  19. Case report 423: Clear-cell sarcoma plantar aspect of right foot

    Energy Technology Data Exchange (ETDEWEB)

    Sartoris, D.J.; Resnick, D.; Haghighi, P.

    1987-06-01

    The case is presented of a 65-year-old woman who developed a painful swelling of the plantar aspect of the right foot over a 3-year period. Conventional roentgenograms of the foot showed a large, soft tissue mass on the plantar aspect, with some suggestion of erosion of the adjacent metatarsals. CT studies, however, failed to confirm the presence of any bony abnormalities. At the time of the initial presentation, a biopsy was performed and approximately 3 months later the patient was treated definitely with wide excision of the mass. Histological sections showed the presence of a clear-cell sarcoma - an uncommon lesion mainly confined to the lower extremities and originating either in tendons or aponeurosis. The differential diagnosis, radiologically and clinically was described, and similarly, the differential diagnosis pathologically was also considered. The clinical, pathological and radiological aspects of clear-cell sarcoma of tendon sheath or aponeurosis were discussed in depth and the treatment and prognosis were considered. The authors stress that the importance of the case from a diagnostic imaging perspective lies in the successful use of CT in defining such a soft tissue neoplasm. The ability of CT to determine the extent of involvement of soft tissue and bone by such a lesion is important. Cross-sectional techniques, including magnetic resonance as well as CT, must be the procedure of choice in the definitive diagnosis and treatment of such lesions.

  20. Preliminary verification of instantaneous air temperature estimation for clear sky conditions based on SEBAL

    Science.gov (United States)

    Zhu, Shanyou; Zhou, Chuxuan; Zhang, Guixin; Zhang, Hailong; Hua, Junwei

    2017-02-01

    Spatially distributed near surface air temperature at the height of 2 m is an important input parameter for the land surface models. It is of great significance in both theoretical research and practical applications to retrieve instantaneous air temperature data from remote sensing observations. An approach based on Surface Energy Balance Algorithm for Land (SEBAL) to retrieve air temperature under clear sky conditions is presented. Taking the meteorological measurement data at one station as the reference and remotely sensed data as the model input, the research estimates the air temperature by using an iterative computation. The method was applied to the area of Jiangsu province for nine scenes by using MODIS data products, as well as part of Fujian province, China based on four scenes of Landsat 8 imagery. Comparing the air temperature estimated from the proposed method with that of the meteorological station measurement, results show that the root mean square error is 1.7 and 2.6 °C at 1000 and 30 m spatial resolution respectively. Sensitivity analysis of influencing factors reveals that land surface temperature is the most sensitive to the estimation precision. Research results indicate that the method has great potentiality to be used to estimate instantaneous air temperature distribution under clear sky conditions.

  1. Gap-Opening, Disk Clearing, and the Survival of the Regular Satellites of Jupiter and Saturn

    Science.gov (United States)

    Estrada, P. R.; Mosqueira, I.

    2003-01-01

    It is only recently that the theory of disk-companion interactions yields migration rates due to the gas tidal torque that are in agreement with numerical simulations and up to an order of magnitude slower than previous estimates. Also, for a weakly turbulent disk, the gap size is controlled primarily by the damping length of acoustic waves launched by the secondary at Lindblad resonances, which in turn depends on whether the waves are 2D or 3D. At least for small azimuthal wavenumbers this damping length is of the order of the radial location of the Lindblad resonance. This may have important consequences for disk dispersal in satellite systems. In the case of Jupiter, it means that the inner Galilean satellites may have jointly opened a gap. On the other hand, in Saturn's system the satellites inside of Titan are probably too small to have opened gaps in the gas disk at the time of their formation; but the possibility exists that, by effectively clearing the gas disk inside its own orbit, Titan may have allowed smaller satellites to survive, depending on whether Titan can clear the disk in a timescale comparable to the migration rates due to gas drag and gas tidal torque for these objects.

  2. Boulders increase resistance to clear-cut logging but not subsequent recolonization rates of boreal bryophytes.

    Science.gov (United States)

    Schmalholz, Martin; Hylander, Kristoffer

    2011-12-01

    The extent to which a plant assemblage might recolonize a disturbed system is in general related to the availability of propagule sources and sites with appropriate conditions for establishment. Both these factors might be sensitive to aspects of spatial heterogeneity. Microtopographic variation may enhance initial resistance by reducing the impact of the disturbance and facilitating establishment of incoming propagules by providing shaded "safe-sites". This study explores the influence of microtopographic heterogeneity (caused by variation in surface boulder cover) on the recolonization of closed-canopy forest floor bryophytes using a chronosequence of 75 spruce-dominated forests in south-central Sweden (2-163 years after clear-cutting). We found that high boulder cover did increase survival and subsequent persistence in young forests at both investigated scales (i.e. 1,000 and 100 m(2)), although this pattern became less evident on the smaller spatial scale. Species accumulation in boulder-poor subplots was not different when surrounded by boulder-rich compared with boulder-poor subplots suggesting short-distance recolonization from boulder-created refugia to be of little importance during recolonization. To conclude, it seems that boulders increase initial resistance to clear-cutting for this bryophyte guild, but that the subsequent recolonization process is more likely to depend on external propagule sources and factors affecting establishment such as the microclimate in the developing stand.

  3. Changes in soil nitrogen cycling under Norway spruce logging residues on a clear-cut

    Science.gov (United States)

    Smolander, Aino; Lindroos, Antti-Jussi; Kitunen, Veikko

    2016-04-01

    In Europe, forest biomass is increasingly being used as a source of energy to replace fossil fuels. In practice, this means that logging residues, consisting of green branches and stem tops, are more commonly harvested. In 2012 logging residues were harvested from about one third of clear-cuts in Finland. Our aim was to study how logging residues affect soil organic matter quality, in particular soil N cycling processes and composition of certain groups of plant secondary compounds, tannins and terpenes. Compounds in these groups were of interest because they are abundant in logging residues, and they have been shown to control soil N cycling. In connection with clear-cutting a Norway spruce stand in southern Finland, we established a controlled field experiment by building logging residue piles (40 kg/m2) on study plots. The piles consisted of fresh spruce branches and tops with green foliage. Control plots with no residues were included (0 kg/m2). Changes in soil organic matter properties have now been monitored for three growing seasons. Logging residues affected organic layer properties strongly. For example, they increased net nitrification and nitrate concentrations. There were also increases in the concentrations of certain terpenes and condensed tannins due to the residues. The significance of logging residues on soil processes and properties will be shown.

  4. Reasoning about embryos, cloning and stem cells: let's get more clear and distinct.

    Science.gov (United States)

    Parker, Malcolm

    2003-01-01

    Plural democratic societies encourage and require the tolerance of disparate views. However, in relation to contentious areas like assisted reproductive technologies and destructive embryo research, tolerance is strained by the normative force of our fundamental beliefs about the moral status of early human forms. Yet in the continuing debates, spokespersons for different positions often do not concede all the implications of their arguments, may sidestep the real moral issues, and can fail to be clear about the foundations on which their arguments and policy advice ultimately rely. Guidelines and statutes can be rendered incoherent by the desire to balance and satisfy opposing values, rather than honestly reflecting the primary values they espouse. I call for greater clarity and honesty as these issues continue to be debated. An uncritical adherence to pluralism will encourage strategic obfuscation, but citizens of democracies need to be clearly informed about all the premises of opposing positions. Decisions about ethically and legally acceptable reproductive technologies ultimately depend on support for one metaphysical grounding at the expense of another. This should be acknowledged, as should its implications for policy.

  5. An optical model for deriving the spectral particulate backscattering coefficients in clear and turbid coastal waters

    Directory of Open Access Journals (Sweden)

    S. P. Tiwari

    2013-02-01

    Full Text Available An optical model is developed based on the diffuse attenuation coefficient (Kd to estimate particulate backscattering coefficients bbp(λ in clear and turbid coastal waters. A large in-situ data set is used to establish robust relationships between bbp(530 and bbp(555 and Kd(490 using an efficient nonlinear least square method which uses the Trust-Region algorithm with Bisquare weights scheme to adjust the coefficients. These relationships are obtained with good correlation coefficients (R2 = 0.786 and 0.790, low Root Mean Square Error (RMSE = 0.00076 and 0.00072 and 95% confidence bounds. The new model is tested with two independent data sets such as the NOMAD SeaWiFS Match-ups and OOXIX IOP algorithm workshop evaluation data set (Version 2.0w APLHA. Results show that the new model makes good retrievals of bbp at all key wavelengths (from 412–683 nm, with statistically significant improvements over other inversion models. Thus, the new model has the potential to improve our knowledge of particulate matters and their optical variability in both clear and turbid coastal waters.

  6. CLEAR Landscape Change Module: Preliminary Draft Coastal Protection and Restoration Authority Master Plan, UTM Zone 15N NAD83, Coastal Louisiana Ecosystem Assessment and Restoration (2007), [clear_ouput_cpra_pdmp_012307

    Data.gov (United States)

    Louisiana Geographic Information Center — The Coastal Louisiana Ecosystem Assessment and Restoration (CLEAR) Framework is an integrated ecosystem forecasting system, designed to simulate ecological change...

  7. The autophagoproteasome a novel cell clearing organelle in baseline and stimulated conditions

    Directory of Open Access Journals (Sweden)

    Paola Lenzi

    2016-07-01

    Full Text Available Protein clearing pathways named autophagy (ATG and ubiquitin proteasome (UP control homeostasis within eukaryotic cells, while their dysfunction produces neurodegeneration. These pathways are viewed as distinct biochemical cascades occurring within specific cytosolic compartments owing pathway-specific enzymatic activity.Recent data strongly challenged the concept of two morphologically distinct and functionally segregated compartments. In fact, preliminary evidence suggests the convergence of these pathways to form a novel organelle named autophagoproteasome. This is characterized in the present study by using a cell line where, mTOR activity is upregulated and autophagy is suppressed. This was reversed dose-dependently by administering the mTOR inhibitor rapamycin. Thus, we could study autophagoproteasomes when autophagy was either suppressed or stimulated. The occurrence of autophagoproteasome was shown also in non-human cell lines. Ultrastructural morphometry, based on the stochiometric binding of immunogold particles allowed the quantitative evaluation of ATG and UP component within autophagoproteasomes. The number of autophagoproteasomes increases following mTOR inhibition. Similarly, mTOR inhibition produces overexpression of both LC3 and P20S particles. This is confirmed by the fact that the ratio of free vs autophagosome-bound LC3 is similar to that measured for P20S, both in baseline conditions and following mTOR inhibition. Remarkably, within autophagoproteasomes there is a slight prevalence of ATG compared with UP components for low rapamycin doses, whereas for higher rapamycin doses UP increases more than ATG. While LC3 is widely present within cytosol, UP is strongly polarized within autophagoproteasomes. These fine details were evident at electron microscopy but could not be deciphered by using confocal microscopy. Despite its morphological novelty autophagoproteasomes appear the natural site where clearing pathways (once believed

  8. The Autophagoproteasome a Novel Cell Clearing Organelle in Baseline and Stimulated Conditions.

    Science.gov (United States)

    Lenzi, Paola; Lazzeri, Gloria; Biagioni, Francesca; Busceti, Carla L; Gambardella, Stefano; Salvetti, Alessandra; Fornai, Francesco

    2016-01-01

    Protein clearing pathways named autophagy (ATG) and ubiquitin proteasome (UP) control homeostasis within eukaryotic cells, while their dysfunction produces neurodegeneration. These pathways are viewed as distinct biochemical cascades occurring within specific cytosolic compartments owing pathway-specific enzymatic activity. Recent data strongly challenged the concept of two morphologically distinct and functionally segregated compartments. In fact, preliminary evidence suggests the convergence of these pathways to form a novel organelle named autophagoproteasome. This is characterized in the present study by using a cell line where, mTOR activity is upregulated and autophagy is suppressed. This was reversed dose-dependently by administering the mTOR inhibitor rapamycin. Thus, we could study autophagoproteasomes when autophagy was either suppressed or stimulated. The occurrence of autophagoproteasome was shown also in non-human cell lines. Ultrastructural morphometry, based on the stochiometric binding of immunogold particles allowed the quantitative evaluation of ATG and UP component within autophagoproteasomes. The number of autophagoproteasomes increases following mTOR inhibition. Similarly, mTOR inhibition produces overexpression of both LC3 and P20S particles. This is confirmed by the fact that the ratio of free vs. autophagosome-bound LC3 is similar to that measured for P20S, both in baseline conditions and following mTOR inhibition. Remarkably, within autophagoproteasomes there is a slight prevalence of ATG compared with UP components for low rapamycin doses, whereas for higher rapamycin doses UP increases more than ATG. While LC3 is widely present within cytosol, UP is strongly polarized within autophagoproteasomes. These fine details were evident at electron microscopy but could not be deciphered by using confocal microscopy. Despite its morphological novelty autophagoproteasomes appear in the natural site where clearing pathways (once believed to be

  9. Weak minimum aberration and maximum number of clear two-factor interactions in 2

    Institute of Scientific and Technical Information of China (English)

    YANG; Guijun

    2005-01-01

    [1]Wu, C. F. J., Chen, Y., A graph-aided method for planning two-level experiments when certain interactions are important, Technometrics, 1992, 34: 162-175.[2]Fries, A., Hunter, W, G., Minimum aberration 2к-p designs, Technometrics, 1980, 22: 601-608.[3]Chen, H., Hedayat, A. S., 2n-l designs with weak minimum aberration, Ann. Statist., 1996, 24: 2536-2548.[4]Chen, J., Some results on 2n-к fractional factorial designs and search for minimum aberration designs, Ann.Statist., 1992, 20: 2124-2141.[5]Chen, J., Intelligent search for 213-6 and 214-7 minimum aberration designs, Statist. Sinica, 1998, 8: 1265-1270.[6]Chen, J., Sun, D. X., Wu, C. F. J., A catalogue of two-level and three-level fractional factorial designs with small runs, Internat. Statist. Rev., 1993, 61: 131-145.[7]Chen, J., Wu, C. F. J., Some results on 2n-к fractional factorial designs with minimum aberration or optimal moments, Ann. Statist., 1991, 19: 1028-1041.[8]Cheng, C. S., Mukerjee, R., Regular fractional factorial designs with minimum aberration and maximum estimation capacity, Ann. Statist., 1998, 26: 2289-2300.[9]Cheng, C. S., Steinberg, D. M., Sun, D. X., Minimum aberration and model robustness for two-level fractional factorial designs, J. Roy. Statist. Soc. Ser. B, 1999, 61: 85-93.[10]Draper, N. R., Lin, D. K. J., Capacity consideration for two-level fractional factorial designs, J. Statist. Plann.Inference, 1990, 24: 25-35.[11]Fang, K. T., Mukerjee, R., A connection between uniformity and aberration in regular fractions of two-level factorial, Biometrika, 2000, 87: 193-198.[12]Tang, B., Wu, C. F. J., Characterization of minimum aberration 2n-к designs in terms of their complementary designs, Ann. Statist., 1996, 24: 2549-2559.[13]Chen, H., Hedayat, A. S., 2n-m designs with resolution Ⅲ or Ⅳ containing clear two-factor interactions, J.Statist. Plann. Inference, 1998, 75: 147-158.[14]Tang, B., Ma, F., Ingram, D., Wang, H., Bounds on the maximum numbers of clear two factor

  10. Effects and Mitigation of Clear Sky Sampling on Recorded Trends in Land Surface Temperature

    Science.gov (United States)

    Holmes, T. R.; Hain, C.; de Jeu, R.; Anderson, M. C.; Crow, W. T.

    2015-12-01

    Land surface temperature (LST) is a key input for physically-based retrieval algorithms of hydrological states and fluxes. Yet, it remains a poorly constrained parameter for global scale studies. The main two observational methods to remotely measure T are based on thermal infrared (TIR) observations and passive microwave observations (MW). TIR is the most commonly used approach and the method of choice to provide standard LST products for various satellite missions. MW-based LST retrievals on the other hand are not as widely adopted for land applications; currently their principle use is in soil moisture retrieval algorithms. MW and TIR technologies present two highly complementary and independent means of measuring LST. MW observations have a high tolerance to clouds but a low spatial resolution, and TIR has a high spatial resolution with temporal sampling restricted to clear skies. This paper builds on recent progress in characterizing the main structural differences between TIR LST and MW Ka-band observations, the MW frequency that is most suitable for LST sensing. By accounting for differences in diurnal timing (phase lag with solar noon), amplitude, and emissivity we construct a MW-based LST dataset that matches the diurnal characteristics of the TIR-based LSA SAF LST record. This new global dataset of MW-based LST currently spans the period of 2003-2013. In this paper we will present results of a validation of MW LST with in situ data with special emphasis on the effect of cloudiness on the performance. The ability to remotely sense the temperature of cloud covered land is what sets this MW-LST datasets apart from existing (much higher resolution) TIR-based products. As an example of this we will therefore explore how MW LST can mitigate the effect of clear-sky sampling in the context of trend and anomaly detection. We do this by contrasting monthly means of TIR-LST with its clear-sky and all-sky equivalent from an MW-LST and an NWP model.

  11. The Autophagoproteasome a Novel Cell Clearing Organelle in Baseline and Stimulated Conditions

    Science.gov (United States)

    Lenzi, Paola; Lazzeri, Gloria; Biagioni, Francesca; Busceti, Carla L.; Gambardella, Stefano; Salvetti, Alessandra; Fornai, Francesco

    2016-01-01

    Protein clearing pathways named autophagy (ATG) and ubiquitin proteasome (UP) control homeostasis within eukaryotic cells, while their dysfunction produces neurodegeneration. These pathways are viewed as distinct biochemical cascades occurring within specific cytosolic compartments owing pathway-specific enzymatic activity. Recent data strongly challenged the concept of two morphologically distinct and functionally segregated compartments. In fact, preliminary evidence suggests the convergence of these pathways to form a novel organelle named autophagoproteasome. This is characterized in the present study by using a cell line where, mTOR activity is upregulated and autophagy is suppressed. This was reversed dose-dependently by administering the mTOR inhibitor rapamycin. Thus, we could study autophagoproteasomes when autophagy was either suppressed or stimulated. The occurrence of autophagoproteasome was shown also in non-human cell lines. Ultrastructural morphometry, based on the stochiometric binding of immunogold particles allowed the quantitative evaluation of ATG and UP component within autophagoproteasomes. The number of autophagoproteasomes increases following mTOR inhibition. Similarly, mTOR inhibition produces overexpression of both LC3 and P20S particles. This is confirmed by the fact that the ratio of free vs. autophagosome-bound LC3 is similar to that measured for P20S, both in baseline conditions and following mTOR inhibition. Remarkably, within autophagoproteasomes there is a slight prevalence of ATG compared with UP components for low rapamycin doses, whereas for higher rapamycin doses UP increases more than ATG. While LC3 is widely present within cytosol, UP is strongly polarized within autophagoproteasomes. These fine details were evident at electron microscopy but could not be deciphered by using confocal microscopy. Despite its morphological novelty autophagoproteasomes appear in the natural site where clearing pathways (once believed to be

  12. Construction of 2Ⅲm-(m-κ) Designs with the Maximum Number of Clear Two-factor Interactions

    Institute of Scientific and Technical Information of China (English)

    Gui-Jun Yang

    2007-01-01

    It is useful to know the maximum number of clear two-factor interactions in a 2Ⅲm-(m-k) design.This paper provides a method to construct a 2Ⅲm-(m-k) design with the maximum number of clear two-factor interactions. And it is proved that the resulting designs have more clear two-factor interactions than those constructed by Tang et al.[6]. Moreover, the designs constructed are shown to have concise grid representations.

  13. 75 FR 17826 - Rescinding the Notice of Intent for an Environmental Impact Statement: Gilpin, Clear Creek, and...

    Science.gov (United States)

    2010-04-07

    ... Statement: Gilpin, Clear Creek, and Jefferson Counties, CO AGENCY: Federal Highway Administration, DOT... Statement that was issued on August 11, 2000, for a proposed transportation improvement project in...

  14. Clear Creek Watershed Flood Risk Management Habitat Assessments Using Habitat Evaluation Procedures (HEP): Analyses, Results and Documentation

    Science.gov (United States)

    2013-07-01

    There are an additional 16 cities that are at least partially within the watershed including Pearland, Friendswood, and League City. Clear Creek...LULC) classes present in the Clear Creek watershed.1 Landuse/Landcover Characterization of the Clear Creek Watershed Legend Clear Creek and...br KAIIr A. _, 1A El\\DC𔃻 EA"’""""’uJ !Abono- lor clio tiSACt-DoalDCn Cltu Ct"k Floo4 IU&k Rt4JCOODI!..-,_ Pro!oa tnMq:OOS Legend Cover Types

  15. A Study of Varlilumab (Anti-CD27) and Sunitinib in Patients With Metastatic Clear Cell Renal Cell Carcinoma

    Science.gov (United States)

    2016-09-15

    Carcinoma, Renal Cell; Kidney Diseases; Kidney Neoplasms; Urogenital Neoplasms; Urologic Diseases; Urologic Neoplasms; Neoplasms; Neoplasms by Histologic Type; Clear-cell Metastatic Renal Cell Carcinoma

  16. OCT Study of Optical Clearing of Muscle Tissue in vitro with 40% Glucose Solution

    Science.gov (United States)

    Genina, E. A.; Bashkatov, A. N.; Kozintseva, M. D.; Tuchin, V. V.

    2016-01-01

    The technique of -optical clearing of biological tissues- is aimed at improving the quality of visualization of structures hidden deep in tissue. In this study, we measured the diffusion coefficient of glucose in bovine skeletal muscle tissue by optical coherence tomography (OCT) in vitro and determined changes that took place in the imaging contrast of muscle fibers, the optical depth of coherent probing, and detection under the influence of aqueous 40% solution of glucose. It was shown that, within 90 min, when the depth of coherent probing increased by 14%, the contrast of OCT images increased fourfold and the depth of coherent detection of structural elements of the tissue increased by 2.4 times. The diffusion coefficient of glucose in the muscle tissue was (2.98 ± 0.94) × 10-6 cm2/s.

  17. Assessment of phacoaspiration techniques in clear lens extraction for correction of high myopia

    Directory of Open Access Journals (Sweden)

    Mostafa A El-Helw

    2010-03-01

    Full Text Available Mostafa A El-Helw, Ahmed M EmarahDepartment of Ophthalmology, Cairo University, EgyptPurpose: To evaluate various phacoaspiration techniques in clear lens extraction for the incidence of intraoperative difficulties and complications.Patients and methods: This was a prospective study in which bilateral clear lens extraction was performed on 40 eyes of 20 patients, to correct high myopia. The patients were divided into 2 groups: group A underwent supracapsular phacoaspiration; group B were the contralateral eyes of the same patient. These patients were operated on with endocapsular phacoaspiration with the divide and conquer (D and C technique. Preoperative ocular examination data were recorded and tested for significance. Intraoperative difficulties and complications such as nucleus cracking, capsule rupture and vitreous loss, and repeated chamber collapse were recorded. Postoperative examination data were recorded.Results: Mean age was 35.65 ± 5.85 years. Mean follow-up time was 17.1 ± 8.56 months. In group A mean myopia was -17.3 ± 5.07 diopters; in group B myopia was -17.9 ± 4.20 diopters. Mean preoperative uncorrected visual acuity (UCVA was 0.04 ± 0.0167, while the mean postoperative UCVA was 0.435 ± 0.1442. There was a significant difference in pre and postoperative BCVA within both groups, but not between the two groups. In both groups endothelial cell count (ECC showed a significant difference between pre- and postoperative data; however, there was no statistically significant difference between both groups in postoperative ECC. The effective phacoaspiration time for group A was 4.6 ± 1.6 seconds, and for group B 9.90 ± 2.27 seconds (P < 0.005. No cases of capsule rupture occurred in group A, but 3 cases occurred in group B (15 % (not significant, P = 0.231. Nucleus cracking did not occur in group A, but in group B 13 cases occurred (65%. Chamber collapse occurred in 4 cases (20% in group A and 5 cases (25% in group B (not

  18. Sediment CO2 efflux from cleared and intact temperate mangrove and tidal flat habitat

    Science.gov (United States)

    Bulmer, Richard; Lundquist, Carolyn; Schwendenmann, Luitgard

    2015-04-01

    Temperate mangroves in Southern Australia and New Zealand have been increasing in extent over the past 50 years, whereas tropical mangroves have declined by 30-50% over a similar time frame to support development of aquaculture, land development and timber production. Tropical mangroves are understood to be an important carbon sink and carbon emissions following clearance are estimated to be significant; comparable or greater than clearance of many terrestrial forest systems. As temperate mangrove clearance is proposed and has already occurred at some locations, it is important to determine potential carbon emissions from temperate mangroves, as well as exploring the factors which may influence emission rates. Here, we investigated the impact of temperate mangrove clearance on CO2 efflux from the sediment to the atmosphere along with a range of other biotic and abiotic factors. Higher CO2 efflux rates were observed within cleared (1.34

  19. Clear double layer Bioplast feeding plate for neonates with cleft palate.

    Science.gov (United States)

    Yilmaz, R Burcu Nur; Mutlu, Meltem; Germec-Cakan, Derya

    2015-01-01

    An infant with cleft palate was referred to cleft clinic of the Orthodontic Department. The mother was concerned to feed the child because of the escape of milk from the nose. Intraoral examination revealed a large palatal cleft extending from hard to soft palate involving uvula. The impression was taken and dental cast obtained. A 3 mm soft and afterward a 1 mm hard Bioplast plate was pressed using Biostar device (Scheu-Dental Gmbh, Iserlohn, Germany) on the model. Finally, a hole was prepared on the anterior part to put a thread through it. The infant tolerated the plate immediately and encounters no difficulties during feeding. The inlaying soft Bioplast plates eliminate the risk of tissue irritation, whereas the covering hard Bioplast plate supplies endurance. The fabrication of the clear Bioplast feeding plate is easy and less time-consuming compared with acrylic plates and may be recommended in crowded and overloaded cleft centers.

  20. Optimized clearing work concept for the BWR containment; Optimiertes Raeumungskonzept fuer SWR-Sicherheitsbehaelter

    Energy Technology Data Exchange (ETDEWEB)

    Kraps, Uwe [AREVA NP GmbH (Germany)

    2012-11-01

    Based on the experiences of reactor dismantling in the NPPs Wuergasse, Obrigheim and Stade an optimized clearing work concept for the BWR containment including the reactor pressure vessel and the biological shield was developed. The concept is focused on the safety objective, the reduction of the collective dose and the reduction of the execution time. Precondition for the decommissioning license was up to now the removal of fuel elements from the reactor; due to the significantly increased period until fulfillment of this premises concepts are developed that can be performed with simultaneous reduction of the radiological inventories and the fire loads. The most important step of the guideline of the concept is the transition from hot to cold. The in-situ disassembling of the reactor internals can be performed with decreased water level in the reactor pressure vessel, with following water treatment and complete shutdown of operational systems. This status allows an accelerated further dismantling of the plant.

  1. Unusual Ultrasound Presentation of Testicular Metastasis from Renal Clear Cell Carcinoma

    Science.gov (United States)

    Dell’Atti, Lucio

    2016-01-01

    Testicular metastases from renal clear cell carcinoma (RCC) are extremely uncommon. To the best of our knowledge, only 32 cases have been reported in the literature. We report a rare case of testicular metastasis from RCC. A 69-year-old patient presented with discomfort and pain in his left testis. He had undergone laparoscopic left radical nephrectomy at another institution. Scrotal ultrasonography revealed a non-palpable lesion at the upper pole of the left testis with hypoechoic aspect, highly suspicious for malignancy. We performed a left inguinal orchiectomy. The testicular lesion was diagnosed as a metastasis from RCC. After orchiectomy, a computed tomography of the chest and abdomen revealed no other metastatic lesions. The patient remains free of clinical recurrence after 20 months without adjuvant therapy.

  2. Critical Clearing Time and Wind Power in Small Isolated Power Systems Considering Inertia Emulation

    Directory of Open Access Journals (Sweden)

    Elías Jesús Medina-Domínguez

    2015-11-01

    Full Text Available The stability and security of small and isolated power systems can be compromised when large amounts of wind power enter them. Wind power integration depends on such factors as power generation capacity, conventional generation technology or grid topology. Another issue that can be considered is critical clearing time (CCT. In this paper, wind power and CCT are studied in a small isolated power system. Two types of wind turbines are considered: a squirrel cage induction generator (SCIG and a full converter. Moreover, the full converter wind turbine’s inertia emulation capability is considered, and its impact on CCT is discussed. Voltage is taken into account because of its importance in power systems of this kind. The study focuses on the small, isolated Lanzarote-Fuerteventura power system, which is expected to be in operation by 2020.

  3. Penn gap rule in phase-change memory materials: No clear evidence for resonance bonds

    Science.gov (United States)

    Shimakawa, K.; Střižik, L.; Wagner, T.; Frumar, M.

    2015-04-01

    Although a proposal of resonance bonds in crystalline phase-change materials based on the GeSbTe system has been provided, we do not find any clear evidence in favor of the proposal. The ellipsometric study demonstrates that a change in the high frequency dielectric constant ɛ∞ between the amorphous and crystalline phases is only scaled by the average bandgap (the Penn gap rule). Even for a pure antimony film, regarded as a prototype resonance bonding material, ɛ∞ was found to follow the Penn gap rule. Experimentally, we did not find any evidence of a significant change in the optical transition matrix element during the phase change, which is necessary to support the idea of resonance bonds.

  4. Penn gap rule in phase-change memory materials: No clear evidence for resonance bonds

    Directory of Open Access Journals (Sweden)

    K. Shimakawa

    2015-04-01

    Full Text Available Although a proposal of resonance bonds in crystalline phase-change materials based on the GeSbTe system has been provided, we do not find any clear evidence in favor of the proposal. The ellipsometric study demonstrates that a change in the high frequency dielectric constant ε∞ between the amorphous and crystalline phases is only scaled by the average bandgap (the Penn gap rule. Even for a pure antimony film, regarded as a prototype resonance bonding material, ε∞ was found to follow the Penn gap rule. Experimentally, we did not find any evidence of a significant change in the optical transition matrix element during the phase change, which is necessary to support the idea of resonance bonds.

  5. Molecular characterization of a citrus yellow vein clearing virus strain from China.

    Science.gov (United States)

    Zhen, Song; Kurth, Elizabeth G; Peremyslov, Valera V; Changyong, Zhou; Dolja, Valerian V

    2015-07-01

    The complete nucleotide sequence of an isolate of citrus yellow vein clearing virus from Yunnan, China (CYVCV-RL), was determined following whole-genome amplification by RT-PCR. The CYVCV-RL genome was 7529 nt in length, excluding the 3' poly (A) tail, and contained six open reading frames (ORFs), resembling that of viruses belonging to the genus Mandarivirus in the family Alphaflexiviridae. Sequence analysis showed that the CYVCV-RL shared the greatest nucleotide sequence identity with the CYVCV-Y1 (JX040635) isolate from Turkey for the whole genome (97.1%), 5' UTR (98.7%), 3' UTR (100.0%), and each of six ORFs (96.5% to 97.8%), suggesting that there is apparent genetic stability among CYVCV isolates of different geographic origin.

  6. Selective cytotoxicity of indirect nonequilibrium atmospheric pressure plasma against ovarian clear-cell carcinoma.

    Science.gov (United States)

    Utsumi, Fumi; Kajiyama, Hiroaki; Nakamura, Kae; Tanaka, Hiromasa; Hori, Masaru; Kikkawa, Fumitaka

    2014-01-01

    Ovarian clear cell carcinoma (CCC) is a histological type of epithelial ovarian cancer that is less responsive to chemotherapy and associated with a poorer prognosis than serous and endometrioid carcinoma. Non-thermal atmospheric pressure plasma which produces reactive species has recently led to an explosion of research in plasma medicine. Plasma treatment can be applied to cancer treatment to induce apoptosis and tumor growth arrest. Furthermore, recent studies have shown that a medium exposed to plasma also has an anti-proliferative effect against cancer in the absence of direct exposure to plasma. In this study, we confirmed whether this indirect plasma has an anti-tumor effect against CCC, and investigated whether this efficacy is selective for cancer cells. Non-thermal atmospheric pressure plasma induced apoptosis in CCC cells, while human peritoneal mesothelial cells remained viable. Non-thermal atmospheric pressure plasma exhibits selective cytotoxicity against CCC cells which are resistant to chemotherapy.

  7. A Comparison of Flare Forecasting Methods, I: Results from the "All-Clear" Workshop

    CERN Document Server

    Barnes, G; Schrijver, C J; Colak, T; Qahwaji, R; Ashamari, O W; Yuan, Y; Zhang, J; McAteer, R T J; Bloomfield, D S; Higgins, P A; Gallagher, P T; Falconer, D A; Georgoulis, M K; Wheatland, M S; Balch, C; Dunn, T; Wagner, E L

    2016-01-01

    Solar flares produce radiation which can have an almost immediate effect on the near-Earth environment, making it crucial to forecast flares in order to mitigate their negative effects. The number of published approaches to flare forecasting using photospheric magnetic field observations has proliferated, with varying claims about how well each works. Because of the different analysis techniques and data sets used, it is essentially impossible to compare the results from the literature. This problem is exacerbated by the low event rates of large solar flares. The challenges of forecasting rare events have long been recognized in the meteorology community, but have yet to be fully acknowledged by the space weather community. During the interagency workshop on "all clear" forecasts held in Boulder, CO in 2009, the performance of a number of existing algorithms was compared on common data sets, specifically line-of-sight magnetic field and continuum intensity images from MDI, with consistent definitions of what ...

  8. Intensive probing of clear air convective fields by radar and instrumented drone aircraft.

    Science.gov (United States)

    Rowland, J. R.

    1972-01-01

    Clear air convective fields were probed in three summer experiments (1969, 1970, and 1971) on an S-band monopulse tracking radar at Wallops Island, Virginia, and a drone aircraft with a takeoff weight of 5.2 kg, wingspan of 2.5 m, and cruising glide speed of 10.3 m/sec. The drone was flown 23.2 km north of the radar and carried temperature, pressure/altitude, humidity, and vertical and airspeed velocity sensors. Extensive time-space convective field data were obtained by taking a large number of RHI and PPI pictures at short intervals of time. The rapidly changing overall convective field data obtained from the radar could be related to the meteorological information telemetered from the drone at a reasonably low cost by this combined technique.

  9. Metastasis of renal clear-cell carcinoma to the oral mucosa, an atypical location.

    Science.gov (United States)

    Maestre-Rodríguez, Oscar; González-García, Raúl; Mateo-Arias, Jesús; Moreno-García, Carlos; Serrano-Gil, Herminia; Villanueva-Alcojol, Laura; Campos-de-Orellana, Ana Ma; Monje-Gil, Florencio

    2009-11-01

    The majority of cases of metastatic tumors involve the mandible and some the maxilla but they are considerably less common in intraoral soft tissues. In addition, the primary tumor is known in the majority of cases; although in one-third of such cases, metastasis is the first clinical manifestation. The most common primary tumors metastasizing to the mouth are lung carcinoma in men and breast carcinoma in women. An oral metastasis implies a serious prognosis, as in the majority of patients there is multiple organ involvement at the time of diagnosis. We present the case of a 52-year old patient with renal pathology who came to the emergency room due to a rapidly increasing gingival tumor. With the provisional clinical diagnosis of a pyogenic granuloma,the tumor was excised. Subsequent anatomopathological analysis revealed a tumor metastasis compatible with clear-cell carcinoma, and its renal origin was confirmed by means of immunohistochemical techniques.

  10. Testing the Two-Layer Model for Correcting Clear Sky Reflectance near Clouds

    Science.gov (United States)

    Wen, Guoyong; Marshak, Alexander; Evans, Frank; Varnai, Tamas; Levy, Rob

    2015-01-01

    A two-layer model (2LM) was developed in our earlier studies to estimate the clear sky reflectance enhancement due to cloud-molecular radiative interaction at MODIS at 0.47 micrometers. Recently, we extended the model to include cloud-surface and cloud-aerosol radiative interactions. We use the LES/SHDOM simulated 3D true radiation fields to test the 2LM for reflectance enhancement at 0.47 micrometers. We find: The simple model captures the viewing angle dependence of the reflectance enhancement near cloud, suggesting the physics of this model is correct; the cloud-molecular interaction alone accounts for 70 percent of the enhancement; the cloud-surface interaction accounts for 16 percent of the enhancement; the cloud-aerosol interaction accounts for an additional 13 percent of the enhancement. We conclude that the 2LM is simple to apply and unbiased.

  11. Metastatic clear cell carcinoma of the kidney: therapeutic role of bevacizumab.

    Science.gov (United States)

    Bukowski, Ronald M

    2010-03-26

    The biology and pathogenesis of clear cell carcinoma of the kidney has been extensively investgated, and the role of von Hipple-Landau gene inactivation and tumor associated angiogenesis is now recognized. Development of vascular endothelial growth factor inhibitors and phase 3 clinical trials utilizing this class of agents has produced a new treatment paradigm for patients with metastatic renal cell carcinoma (RCC). One of the active regimens identified is the combination of bevacizumab and interferon-α. Recently published reports provided evidence of the clinical and biologic activity of this therapy. The current manuscript reviews the background and rationale for the activity of bevacizumab in RCC, and results from recent clinical trials with this agent alone or in combination with targeted agents or cytokines. The role of this therapy in contrast to other targeted agents is reviewed, and the potential utility as well as questions raised by recent studies are discussed.

  12. Serial Pancreas, Liver and Duodenal Metastasis from Renal Clear Cell Cancer: a Case Report

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ Case Report In August 2004, a 76-year-old patient was referred to our hospital for progressive loss of appetite, accompanied with mild upper abdominal distention, pain, hiccups and dyspepsia over a recent 3 months period. Reviewing his disease history showed that 16 months before admission (April 2003), he was diagnosed with a recurring left renal clear cell cancer (immunohistochemical staining of tumor cells were positive for CK and Vim, but negative for SMA, HMB-45 and HHF-35, Fig. 1) 10 years after a nephrectomy due to a right renal cancer. At that time, he was treated with photodynamic therapy followed by bio-immunotherapy(interleukine-2 plus lymphokine-activated killer cells). Follow-up by an abdominal CT scan every 3 months showed significant regression of the left renal carcinoma.

  13. Dust inputs and bacteria influence dissolved organic matter in clear alpine lakes.

    Science.gov (United States)

    Mladenov, N; Sommaruga, R; Morales-Baquero, R; Laurion, I; Camarero, L; Diéguez, M C; Camacho, A; Delgado, A; Torres, O; Chen, Z; Felip, M; Reche, I

    2011-01-01

    Remote lakes are usually unaffected by direct human influence, yet they receive inputs of atmospheric pollutants, dust, and other aerosols, both inorganic and organic. In remote, alpine lakes, these atmospheric inputs may influence the pool of dissolved organic matter, a critical constituent for the biogeochemical functioning of aquatic ecosystems. Here, to assess this influence, we evaluate factors related to aerosol deposition, climate, catchment properties, and microbial constituents in a global dataset of 86 alpine and polar lakes. We show significant latitudinal trends in dissolved organic matter quantity and quality, and uncover new evidence that this geographic pattern is influenced by dust deposition, flux of incident ultraviolet radiation, and bacterial processing. Our results suggest that changes in land use and climate that result in increasing dust flux, ultraviolet radiation, and air temperature may act to shift the optical quality of dissolved organic matter in clear, alpine lakes.

  14. Ultrasound guided electrochemotherapy for the treatment of a clear cell thymoma in a cat

    Science.gov (United States)

    Spugnini, Enrico Pierluigi; Menicagli, Francesco; Pettorali, Michela; Baldi, Alfonso

    2017-01-01

    A twelve-year-old male castrated domestic shorthair cat was presented for rapidly progressing respiratory distress. The cat was depressed, tachypneic and moderately responsive. Ultrasonography showed a mediastinal mass associated with a significant pleural effusion that needed tapping every five to seven days. Ultrasound guided biopsy yielded a diagnosis of clear cell thymoma upon histopathology. After complete staging procedures, the owner elected to treat the cat with electrochemotherapy (ECT) using systemic bleomycin. Two sessions of ultrasound guided ECT were performed at two week intervals with trains of biphasic electric pulses applied using needle electrodes until complete coverage of the area was achieved. The treatment was well tolerated and resulted in partial remission (PR). Additional sessions were performed on a monthly basis. The cat is still in PR after fourteen months. ECT resulted in improved local control and should be considered among the available adjuvant treatments in pets carrying visceral tumors. PMID:28331834

  15. Water Vapour Absorption in the Clear Atmosphere of an exo-Neptune

    CERN Document Server

    Fraine, Jonathan; Benneke, Björn; Knutson, Heather; Jordán, Andrés; Espinoza, Néstor; Madhusudhan, Nikku; Wilkins, Ashlee; Todorov, Kamen

    2014-01-01

    Transmission spectroscopy to date has detected atomic and molecular absorption in Jupiter-sized exoplanets, but intense efforts to measure molecular absorption in the atmospheres of smaller (Neptune-sized) planets during transits have revealed only featureless spectra. From this it was concluded that the majority of small, warm planets evolve to sustain high mean molecular weights, opaque clouds, or scattering hazes in their atmospheres, obscuring our ability to observe the composition of these atmospheres. Here we report observations of the transmission spectrum of HAT-P-11b (~4 Earth radii) from the optical to the infrared. We detected water vapour absorption at 1.4 micrometre wavelength. The amplitude of the water absorption (approximately 250 parts-per- million) indicates that the planetary atmosphere is predominantly clear down to ~1 mbar, and sufficiently hydrogen-rich to exhibit a large scale height. The spectrum is indicative of a planetary atmosphere with an upper limit of ~700 times the abundance of...

  16. A cryogenic rotation stage with a large clear aperture for a half-wave plate

    CERN Document Server

    Bryan, Sean; Amiri, Mandana; Benton, Steven; Bihary, Richard; Bock, James; Bond, J Richard; Chiang, H Cynthia; Contaldi, Carlo; Crill, Brendan; Dore, Olivier; Elder, Benjamin; Filippini, Jeffrey; Fraisse, Aurelien; Gambrel, Anne; Gandilo, Natalie; Gudmundsson, Jon; Hasselfield, Matthew; Halpern, Mark; Hilton, Gene; Holmes, Warren; Hristov, Viktor; Irwin, Kent; Jones, William; Kermish, Zigmund; Lawrie, Craig; MacTavish, Carrie; Mason, Peter; Megerian, Krikor; Moncelsi, Lorenzo; Montroy, Thomas; Morford, Tracy; Nagy, Johanna; Netterfield, C Barth; Rahlin, Alexandra S; Reintsema, Carl; Riley, Daniel C; Ruhl, John; Runyan, Marcus; Saliwanchik, Benjamin; Shariff, Jamil; Soler, Juan; Trangsrud, Amy; Tucker, Carole; Tucker, Rebecca; Turner, Anthony; Wen, Shyang; Wiebe, Donald; Young, Edward

    2016-01-01

    We describe the cryogenic half-wave plate rotation mechanisms built for and used in Spider, a polarization-sensitive balloon-borne telescope array that observed the Cosmic Microwave Background at 95 GHz and 150 GHz during a stratospheric balloon flight from Antarctica in January 2015. The mechanisms operate at liquid helium temperature in flight. A three-point contact design keeps the mechanical bearings relatively small but allows for a large (305 mm) diameter clear aperture. A worm gear driven by a cryogenic stepper motor allows for precise positioning and prevents undesired rotation when the motors are depowered. A custom-built optical encoder system monitors the bearing angle to an absolute accuracy of 0.1 degrees. The system performed well in Spider during its successful 16 day flight.

  17. Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium.

    Science.gov (United States)

    Maltez, Vivien I; Tubbs, Alan L; Cook, Kevin D; Aachoui, Youssef; Falcone, E Liana; Holland, Steven M; Whitmire, Jason K; Miao, Edward A

    2015-11-17

    Defective neutrophils in patients with chronic granulomatous disease (CGD) cause susceptibility to extracellular and intracellular infections. Microbes must first be ejected from intracellular niches to expose them to neutrophil attack, so we hypothesized that inflammasomes detect certain CGD pathogens upstream of neutrophil killing. Here, we identified one such ubiquitous environmental bacterium, Chromobacterium violaceum, whose extreme virulence was fully counteracted by the NLRC4 inflammasome. Caspase-1 protected via two parallel pathways that eliminated intracellular replication niches. Pyroptosis was the primary bacterial clearance mechanism in the spleen, but both pyroptosis and interleukin-18 (IL-18)-driven natural killer (NK) cell responses were required for liver defense. NK cells cleared hepatocyte replication niches via perforin-dependent cytotoxicity, whereas interferon-γ was not required. These insights suggested a therapeutic approach: exogenous IL-18 restored perforin-dependent cytotoxicity during infection by the inflammasome-evasive bacterium Listeria monocytogenes. Therefore, inflammasomes can trigger complementary programmed cell death mechanisms, directing sterilizing immunity against intracellular bacterial pathogens.

  18. Clouds and Clearings in the Atmospheres of the L and T Dwarfs

    CERN Document Server

    Marley, M S; Burgasser, A J; Saumon, D S; Lodders, K; Freedman, R

    2002-01-01

    A sophisticated approach to condensate opacity is required to properly model the atmospheres of L and T dwarfs. Here we review different models for the treatment of condensates in brown dwarf atmospheres. We conclude that models which include both particle sedimentation and upwards transport of condensate (both gas and particles) provide the best fit for the L dwarf colors. While a globally uniform cloud model fits the L dwarf data, it turns to the blue in J-K too slowly to fit the T dwarfs. Models which include local clearings in the global cloud deck, similar to Jupiter's prominent five-micron hot spots, better reproduce the available photometric data and also account for the observed resurgence of FeH absorption in early type T dwarfs.

  19. [Major results of research and development of heterogenous biocatalysts for regenerated water clearing from harmful admixture].

    Science.gov (United States)

    2012-01-01

    The biological method of clearing atmospheric condensate in pressurized habitats exploits filters with a heterogenic biocatalyst produced by way of immobilizing harmless for human, animal and plant microoganisms on water-insoluble solid carrier--foam polyvinyl-formal (FPVF), and a hydrogen peroxide biofilter containing triacetate cellulose-immobilized catalase. Experience of forming an immobilized bacterial association as a polyenzyme system is particularly promising for development of advanced biotechnologies. Biocatalysts with expanded applicability can be manufactured using a FPVF-immobilized associative bacterial culture composed of Paracoccus denitrificans, Pseudomonas esterophilus and Methilopila capsulata. In aerobic condition at room temperature the heterogenic biocatalyst is capable to transform harmful organics in atmospheric condensate, e.g. methyl amine, ethyl acetate, acetic acid, ethanol and acetone into the end-products, i.e. carbon dioxide and water. Ammonia is consumed by 3 cultures as a source of nitrogen.

  20. Measured and computed values of clear-sky ultraviolet irradiances at the South Pole

    Energy Technology Data Exchange (ETDEWEB)

    Rao, C.R.N.; Takashima, T.

    1985-01-01

    Baker-Blocker et al.(1) have recently presented and discussed broadband (approx. = 0.290-0.380 ..mu..) ultraviolet irradiances measured under clear skies at Amundsen-Scott station (90 /sup 0/S), South Pole, during the austral summers of 1978-79, 1979-80 and 1980-81. These measurements, made with an Eppley Model TUVR radiometer, are unique in that they have been obtained under atmospheric conditions which are very close to what would prevail in an ideal, dust- and cloud-free pure molecular (Rayleigh) atmosphere (1,2); thus, the attenuation of the incoming solar radiation may be considered as essentially being due to absorption by atmospheric ozone in the Hartley (up to approx. = 0.300 ..mu..) and Huggins (approx. = 0.300-0.360 ..mu..) bands and to molecular (Rayleigh) scattering. Against this background, we presently wish to compare these measurements with computed values of the broadband ultraviolet irradiance in simple atmospheric models.

  1. Imaging Nuclear Morphology and Organization in Cleared Plant Tissues Treated with Cell Cycle Inhibitors.

    Science.gov (United States)

    de Souza Junior, José Dijair Antonino; de Sa, Maria Fatima Grossi; Engler, Gilbert; Engler, Janice de Almeida

    2016-01-01

    Synchronization of root cells through chemical treatment can generate a large number of cells blocked in specific cell cycle phases. In plants, this approach can be employed for cell suspension cultures and plant seedlings. To identify plant cells in the course of the cell cycle, especially during mitosis in meristematic tissues, chemical inhibitors can be used to block cell cycle progression. Herein, we present a simplified and easy-to-apply protocol to visualize mitotic figures, nuclei morphology, and organization in whole Arabidopsis root apexes. The procedure is based on tissue clearing, and fluorescent staining of nuclear DNA with DAPI. The protocol allows carrying out bulk analysis of nuclei and cell cycle phases in root cells and will be valuable to investigate mutants like overexpressing lines of genes disturbing the plant cell cycle.

  2. Clear Evidence for Fe-60 in Silicate from a Semarkona Chondrule

    Science.gov (United States)

    Huss, G. R.; Tachibana, S.

    2004-01-01

    Fe-60 (t(sub 1/2) = 1.5 Ma) is key to understanding the sources of short-lived radionuclides in the early solar system because it is the only one among those known from meteoritic material that is produced only in stars [1]. Within the last year, it has become clear that Fe-60 was present in sulfides from primitive ordinary and enstatite chondrites in amounts sufficient to require a recent stellar input [2-5]. The sulfide data indicate an initial Fe-60/Fe-56 ratio for the early solar system of between approx. 3 10(exp -7) and approx. 1.6 10(exp -6) [2-4]. However, iron (and nickel?) in sulfides is easily mobilized by very mild heating [e.g., 6], so there is considerable uncertainty over the true initial ratio. To resolve this uncertainty, we have begun a search for evidence of Fe-60 in silicates from primitive chondrites. In olivine from type 3.0-3.1 ordinary chondrites, diffusive exchange of iron and magnesium has not occurred to any significant degree, and diffusive exchange in pyroxene is slower [7]. However, the relatively small elemental fractionation of iron from nickel in silicates, coupled with the fact that the daughter nuclide, Ni-60, makes up approx. 26 % of normal nickel, make detection of excesses of radiogenic Ni-60 very difficult. Fortunately, we have found a fine-grained radiating-pyroxene chondrule in Semarkona (LL3.0) with a very high Fe/Ni ratio that gives clear evidence of Fe-60.

  3. Positive edge effects on forest-interior cryptogams in clear-cuts.

    Directory of Open Access Journals (Sweden)

    Alexandro Caruso

    Full Text Available Biological edge effects are often assessed in high quality focal habitats that are negatively influenced by human-modified low quality matrix habitats. A deeper understanding of the possibilities for positive edge effects in matrix habitats bordering focal habitats (e.g. spillover effects is, however, essential for enhancing landscape-level resilience to human alterations. We surveyed epixylic (dead wood inhabiting forest-interior cryptogams (lichens, bryophytes, and fungi associated with mature old-growth forests in 30 young managed Swedish boreal forest stands bordering a mature forest of high conservation value. In each young stand we registered species occurrences on coarse dead wood in transects 0-50 m from the border between stand types. We quantified the effect of distance from the mature forest on the occurrence of forest-interior species in the young stands, while accounting for local environment and propagule sources. For comparison we also surveyed epixylic open-habitat (associated with open forests and generalist cryptogams. Species composition of epixylic cryptogams in young stands differed with distance from the mature forest: the frequency of occurrence of forest-interior species decreased with increasing distance whereas it increased for open-habitat species. Generalists were unaffected by distance. Epixylic, boreal forest-interior cryptogams do occur in matrix habitats such as clear-cuts. In addition, they are associated with the matrix edge because of a favourable microclimate closer to the mature forest on southern matrix edges. Retention and creation of dead wood in clear-cuts along the edges to focal habitats is a feasible way to enhance the long-term persistence of epixylic habitat specialists in fragmented landscapes. The proposed management measures should be performed in the whole stand as it matures, since microclimatic edge effects diminish as the matrix habitat matures. We argue that management that aims to increase

  4. Positive edge effects on forest-interior cryptogams in clear-cuts.

    Science.gov (United States)

    Caruso, Alexandro; Rudolphi, Jörgen; Rydin, Håkan

    2011-01-01

    Biological edge effects are often assessed in high quality focal habitats that are negatively influenced by human-modified low quality matrix habitats. A deeper understanding of the possibilities for positive edge effects in matrix habitats bordering focal habitats (e.g. spillover effects) is, however, essential for enhancing landscape-level resilience to human alterations. We surveyed epixylic (dead wood inhabiting) forest-interior cryptogams (lichens, bryophytes, and fungi) associated with mature old-growth forests in 30 young managed Swedish boreal forest stands bordering a mature forest of high conservation value. In each young stand we registered species occurrences on coarse dead wood in transects 0-50 m from the border between stand types. We quantified the effect of distance from the mature forest on the occurrence of forest-interior species in the young stands, while accounting for local environment and propagule sources. For comparison we also surveyed epixylic open-habitat (associated with open forests) and generalist cryptogams. Species composition of epixylic cryptogams in young stands differed with distance from the mature forest: the frequency of occurrence of forest-interior species decreased with increasing distance whereas it increased for open-habitat species. Generalists were unaffected by distance. Epixylic, boreal forest-interior cryptogams do occur in matrix habitats such as clear-cuts. In addition, they are associated with the matrix edge because of a favourable microclimate closer to the mature forest on southern matrix edges. Retention and creation of dead wood in clear-cuts along the edges to focal habitats is a feasible way to enhance the long-term persistence of epixylic habitat specialists in fragmented landscapes. The proposed management measures should be performed in the whole stand as it matures, since microclimatic edge effects diminish as the matrix habitat matures. We argue that management that aims to increase habitat quality

  5. Colour stabilities of three types of orthodontic clear aligners exposed to staining agents

    Institute of Scientific and Technical Information of China (English)

    Chen-Lu Liu; Wen-Tian Sun; Wen Liao; Wen-Xin Lu; Qi-Wen Li; Yunho Jeong; Jun Liu; Zhi-He Zhao

    2016-01-01

    The aim of this study was to evaluate and compare the colour stabilities of three types of orthodontic clear aligners exposed to staining agents in vitro. Sixty clear orthodontic aligners produced by three manufacturers (Invisalign, Angelalign, and Smartee) were immersed in three staining solutions (coffee, black tea, and red wine) and one control solution (distilled water). After 12-h and 7-day immersions, the aligners were washed in an ultrasonic cleaner and measured with a colourimeter. The colour changes (ΔE*) were calculated on the basis of the Commission Internationale de I’Eclairage L*a*b*colour system (CIE L*a*b*), and the results were then converted into National Bureau of Standards (NBS) units. Fourier transformation infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) were conducted to observe the molecular and morphologic alterations to the aligner surfaces, respectively. The three types of aligners exhibited slight colour changes after 12 h of staining, with the exception of the Invisalign aligners stained with coffee. The Invisalign aligners exhibited significantly higherΔE*values (ranging from 0.30 to 27.81) than those of the Angelalign and Smartee aligners (ΔE*values ranging from 0.33 to 1.89 and 0.32 to 1.61, respectively, Po0.05). FT-IR analysis confirmed that the polymer-based structure of aligners did not exhibit significant chemical differences before and after the immersions. The SEM results revealed different surface alterations to the three types of aligner materials after the 7-day staining. The three types of aesthetic orthodontic appliances exhibited colour stability after the 12-h immersion, with the exception of the Invisalign aligners stained by coffee. The Invisalign aligners were more prone than the Angelalign and Smartee aligners to pigmentation. Aligner materials may be improved by considering aesthetic colour stability properties.

  6. HST Hot-Jupiter Transmission Spectral Survey: Clear Skies for Cool Saturn WASP-39b

    Science.gov (United States)

    Fischer, Patrick D.; Knutson, Heather A.; Sing, David K.; Henry, Gregory W.; Williamson, Michael W.; Fortney, Jonathan J.; Burrows, Adam S.; Kataria, Tiffany; Nikolov, Nikolay; Showman, Adam P.; Ballester, Gilda E.; Désert, Jean-Michel; Aigrain, Suzanne; Deming, Drake; Lecavelier des Etangs, Alain; Vidal-Madjar, Alfred

    2016-08-01

    We present the Hubble Space Telescope (HST) Space Telescope Imaging Spectrograph (STIS) optical transmission spectroscopy of the cool Saturn-mass exoplanet WASP-39b from 0.29-1.025 μm, along with complementary transit observations from Spitzer IRAC at 3.6 and 4.5 μm. The low density and large atmospheric pressure scale height of WASP-39b make it particularly amenable to atmospheric characterization using this technique. We detect a Rayleigh scattering slope as well as sodium and potassium absorption features; this is the first exoplanet in which both alkali features are clearly detected with the extended wings predicted by cloud-free atmosphere models. The full transmission spectrum is well matched by a clear H2-dominated atmosphere, or one containing a weak contribution from haze, in good agreement with the preliminary reduction of these data presented in Sing et al. WASP-39b is predicted to have a pressure-temperature profile comparable to that of HD 189733b and WASP-6b, making it one of the coolest transiting gas giants observed in our HST STIS survey. Despite this similarity, WASP-39b appears to be largely cloud-free, while the transmission spectra of HD 189733b and WASP-6b both indicate the presence of high altitude clouds or hazes. These observations further emphasize the surprising diversity of cloudy and cloud-free gas giant planets in short-period orbits and the corresponding challenges associated with developing predictive cloud models for these atmospheres.

  7. 3-D neurohistology of transparent tongue in health and injury with optical clearing

    Directory of Open Access Journals (Sweden)

    Tzu-En eHua

    2013-10-01

    Full Text Available Tongue receives extensive innervation to perform taste, sensory, and motor functions. Details of the tongue neuroanatomy and its plasticity in response to injury offer insights to investigate tongue neurophysiology and pathophysiology. However, due to the dispersed nature of the neural network, standard histology cannot provide a global view of the innervation. We prepared transparent mouse tongue by optical clearing to reveal the spatial features of the tongue innervation and its remodeling in injury. Immunostaining of neuronal markers, including PGP9.5 (pan-neuronal marker, calcitonin gene-related peptide (sensory nerves, tyrosine hydroxylase (sympathetic nerves, and vesicular acetylcholine transporter (cholinergic parasympathetic nerves and neuromuscular junctions, was combined with vessel painting and nuclear staining to label the tissue network and architecture. The tongue specimens were immersed in the optical-clearing solution to facilitate photon penetration for 3-dimensiontal (3-D confocal microscopy. Taking advantage of the transparent tissue, we simultaneously revealed the tongue microstructure and innervation with subcellular-level resolution. 3-D projection of the papillary neurovascular complex and taste bud innervation was used to demonstrate the spatial features of tongue mucosa and the panoramic imaging approach. In the tongue injury induced by 4-nitroquinoline 1-oxide administration in the drinking water, we observed neural tissue remodeling in response to the changes of mucosal and muscular structures. Neural networks and the neuromuscular junctions were both found rearranged at the peri-lesional region, suggesting the nerve-lesion interactions in response to injury. Overall, this new tongue histological approach provides a useful tool for 3-D imaging of neural tissues to better characterize their roles with the mucosal and muscular components in health and disease.

  8. VLT FORS2 comparative transmission spectral survey of clear and cloudy exoplanet atmospheres

    Science.gov (United States)

    Nikolov, Nikolay; Sing, David; Gibson, Neale; Evans, Thomas; Barstow, Joanna Katy; Kataria, Tiffany; Wilson, Paul A.

    2016-10-01

    Transmission spectroscopy is a key to unlocking the secrets of close-in exoplanet atmospheres. Observations have started to unveil a vast diversity of irradiated giant planet atmospheres with clouds and hazes playing a definitive role across the entire mass and temperature regime. We have initiated a ground-based, multi-object transmission spectroscopy of a hand full of hot Jupiters, covering the wavelength range 360-850nm using the recently upgraded FOcal Reducer and Spectrograph (FORS2) mounted on the Very Large Telescope (VLT) at the European Southern Observatory (ESO). These targets were selected for comparative follow-up as their transmission spectra showed evidence for alkali metal absorption, based on the results of Hubble Space Telescope (HST) observations. This talk will discuss the first results from the programme, demonstrating excellent agreement between the transmission spectra measured from VLT and HST and further reinforce the findings of clear, cloudy and hazy atmospheres. More details will be discussed on the narrow alkali features obtained with FORS2 at higher resolution, revealing its high potential in securing optical transmission spectra. These FORS2 observations are the first ground-based detections of clear, cloudy and hazy hot-Jupiter atmosphere with a simultaneous detections of Na, K, and H2 Rayleigh scattering. Our program demonstrates the large potential of the instrument for optical transmission spectroscopy, capable of obtaining HST-quality light curves from the ground. Compared to HST, the larger aperture of VLT will allow for fainter targets to be observed and higher spectral resolution, which can greatly aid comparative exoplanet studies. This is important for further exploring the diversity of exoplanet atmospheres and is particularly complementary to the near- and mid-IR regime, to be covered by the upcoming James-Webb Space Telescope (JWST) and is readily applicable to less massive planets down to super-Earths.

  9. Ultraviolet actinic flux in clear and cloudy atmospheres: model calculations and aircraft-based measurements

    Directory of Open Access Journals (Sweden)

    G. G. Palancar

    2011-06-01

    Full Text Available Ultraviolet (UV actinic fluxes measured with two Scanning Actinic Flux Spectroradiometers (SAFS aboard the NASA DC-8 aircraft are compared with the Tropospheric Ultraviolet-Visible (TUV model. The observations from 17 days in July-August 2004 (INTEX-NA field campaign span a wide range of latitudes (28° N–53° N, longitudes (45° W–140° W, altitudes (0.1–11.9 km, ozone columns (285–353 DU, and solar zenith angles (2°–85°. Both cloudy and cloud-free conditions were encountered. For cloud-free conditions, the ratio of observed to clear-sky-model actinic flux (integrated from 298 to 422 nm was 1.01±0.04, i.e. in good agreement with observations. The agreement improved to 1.00±0.03 for the down-welling component under clear sky conditions. In the presence of clouds and depending on their position relative to the aircraft, the up-welling component was frequently enhanced (by as much as a factor of 8 relative to cloud-free values while the down-welling component showed both reductions and enhancements of up to a few tens of percent. Including all conditions, the ratio of the observed actinic flux to the cloud-free model value was 1.1±0.3 for the total, or separately 1.0±0.2 for the down-welling and 1.5±0.8 for the up-welling components. The correlations between up-welling and down-welling deviations are well reproduced with sensitivity studies using the TUV model, and are understood qualitatively with a simple conceptual model. This analysis of actinic flux observations illustrates opportunities for future evaluations of photolysis rates in three-dimensional chemistry-transport models.

  10. Infrared Signatures of Bacillus Bacteria: Clear IR Distinctions Between Sporulated and Vegetative Cells with Chemical Assighments

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Timothy J.; Williams, Stephen D.; Valentine, Nancy B.; Su, Yin-Fong; Kreuzer-Martin, Helen W.; Wahl, Karen L.; Forrester, Joel B.

    2009-05-04

    This paper highlights the distinctions between the infrared (IR) absorption spectra of vegetative versus sporulated Bacillus bacteria. It is observed that there are unique signatures clearly associated with either the sporulated or the vegetative state, and that vegetative cells (and associated debris) can contribute to the spore spectra. A distinct feature at ~1739 cm-1 appears to be unique to vegetative cell spectra, and can also be used as an indicator of vegetative cells or cell debris in the spore spectra. The data indicate the band is caused by a phospholipid carbonyl bond and are consistent with, but do not prove it to be, either phosphatidyl ethanolamine (PE) or phosphatidyl glycerol (PG), the two major classes of phospholipids found in vegetative cells of Bacillus species. The endospore spectra show characteristic peaks at 1441, 1277, and 1015 cm-1 along with a distinct quartet of peaks at 766, 725, 701, and 659 cm-1. These are clearly associated with calcium dipicolinate trihydrate, CaDP•3H2O. We emphasize that the spore peaks, especially the quartet, arise from the calcium dipicolinate trihydrate and not from dipicolinic acid or other dipicolinate hydrate salts. The CaDP•3H2O vibrational peaks and the effects of hydration were studied using quantum chemistry in the PQS software package. The quartet is associated with many motions including contributions from the Ca2+ counterion and hydration waters including Ca-O-H bends, H2O-Ca-O torsions and O-C-O bends. The 1441 and 1015 cm-1 modes are planar pyridine modes with the 1441 mode primarily a ring C-N stretch and the 1015 mode primarily a ring C-C stretch.

  11. Infrared signatures of Bacillus bacteria: Clear IR distinctions between sporulated and vegetative cells with chemical assignments

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Timothy J.; Williams, Stephen D.; Valentine, Nancy B.; Su, Yin-Fong; Kreuzer-Martin, Helen W.; Wahl, Karen L.; Forrester, Joel B.

    2009-05-08

    This paper highlights the distinctions between the infrared (IR) absorption spectra of vegetative versus sporulated Bacillus bacteria. It is observed that there are unique signatures clearly associated with either the sporulated or the vegetative state, and that vegetative cells (and associated debris) can contribute to the spore spectra. A distinct feature at ~1739 cm-1 appears to be unique to vegetative cell spectra, and can also be used as an indicator of vegetative cells or cell debris in the spore spectra. The data indicate the band is caused by a phospholipid carbonyl bond and are consistent with, but do not prove it to be, either phosphatidyl ethanolamine (PE) or phosphatidyl glycerol (PG), the two major classes of phospholipids found in vegetative cells of Bacillus species. The endospore spectra show characteristic peaks at 1441, 1277, and 1015 cm-1 along with a distinct quartet of peaks at 766, 725, 701, and 659 cm-1. These are clearly associated with calcium dipicolinate trihydrate, CaDP•3H2O. We emphasize that the spore peaks, especially the quartet, arise from the calcium dipicolinate trihydrate and not from dipicolinic acid or other dipicolinate hydrate salts. The CaDP•3H2O vibrational peaks and the effects of hydration were studied using quantum chemistry in the PQS software package. The quartet is associated with many motions including contributions from the Ca2+ counterion and hydration waters including Ca-O-H bends, H2O-Ca-O torsions and O-C-O bends. The 1441 and 1015 cm-1 modes are planar pyridine modes with the 1441 mode primarily a ring C-N stretch and the 1015 mode primarily a ring C-C stretch.

  12. Diagnostic utility of hepatocyte nuclear factor 1-beta immunoreactivity in endometrial carcinomas: lack of specificity for endometrial clear cell carcinoma.

    Science.gov (United States)

    Fadare, Oluwole; Liang, Sharon X

    2012-12-01

    Hepatocyte nuclear factor 1-beta (HNF1β) has recently emerged as a relatively sensitive and specific marker for ovarian clear cell carcinoma. The purpose of this study is to assess the diagnostic utility of this marker for endometrial clear cell carcinoma. Immunohistochemical analysis was performed on 75 endometrial tissues using a goat polyclonal antibody raised against a peptide mapping at the C-terminus of human HNF1β protein. The 75 cases included 15 clear cell carcinomas, 20 endometrioid carcinomas, 15 endometrial serous carcinomas/uterine papillary serous carcinomas, 20 cases of normal endometrium, 2 cases of clear cell metaplasia, and 3 cases of Arias Stella reaction. Staining interpretations were based on a semiquantitative scoring system, a 0 to 12+ continuous numerical scale that was derived by multiplying the extent of staining (0 to 4+ scale) by the intensity of staining (0 to 3+ scale) for each case. HNF1β expression was found to be present in a wide spectrum of tissues. Twenty-seven (54%) of the 50 carcinomas displayed at least focal nuclear HNF1β expression, including 11 (73%) of 15, 9 (60%) of 15, and 7 (35%) of 20 clear cell, serous, and endometrioid carcinomas, respectively. The average nuclear staining scores for clear cell carcinomas, endometrioid carcinomas, and serous carcinomas were 5.2, 1.4, and 4.1, respectively. Clear cell carcinomas and endometrioid carcinomas displayed statistically significant differences regarding their nuclear staining scores (P = 0.0027), but clear cell carcinomas and endometrial serous carcinomas did not (P = 0.45). The calculated sensitivity of any nuclear HNF1β expression in classifying a carcinoma as being of the clear cell histotype was 73%, whereas the specificity was 54%. Nineteen of 20 normal endometrium samples displayed at least focal nuclear expression of HNF1β, and this expression was often diffuse. The 5 cases of benign histologic mimics of clear cell carcinomas (Arias Stella reaction and clear

  13. A clearing house for diagnostic testing: the solution to ensure access to and use of patented genetic inventions?

    Science.gov (United States)

    van Zimmeren, Esther; Verbeure, Birgit; Matthijs, Gert; Van Overwalle, Geertrui

    2006-01-01

    In genetic diagnostics, the emergence of a so-called "patent thicket" is imminent. Such an overlapping set of patent rights may have restrictive effects on further research and development of diagnostic tests, and the provision of clinical diagnostic services. Currently, two models that may facilitate access to and use of patented genetic inventions are attracting much debate in various national and international fora: patent pools and clearing houses. In this article, we explore the concept of clearing houses. Several types of clearing houses are identified. First, we describe and discuss two types that would provide access to information on the patented inventions: the information clearing house and the technology exchange clearing house. Second, three types of clearing houses are analysed that not only offer access to information but also provide an instrument to facilitate the use of the patented inventions: the open access clearing house, the standardized licences clearing house and the royalty collection clearing house. A royalty collection clearing house for genetic diagnostic testing would be the most comprehensive as it would serve several functions: identifying patents and patent claims essential to diagnostic testing, matching licensees with licensors, developing and supplying standardized licences, collecting royalties, monitoring whether users respect licensing conditions, and providing dispute resolution services such as mediation and arbitration. In this way, it might function as an effective model for users to facilitate access to and use of the patented inventions. However, it remains to be seen whether patent holders with a strong patent portfolio will be convinced by the advantages of the royalty collection clearing house and be willing to participate. PMID:16710543

  14. Use of Atmospheric Infrared Sounder clear-sky and cloud-cleared radiances in the Weather Research and Forecasting 3DVAR assimilation system for mesoscale weather predictions over the Indian region

    Science.gov (United States)

    Singh, Randhir; Kishtawal, C. M.; Pal, P. K.

    2011-11-01

    A set of assimilation experiments is conducted with the Three-Dimensional Variational (3DVAR) data assimilation system associated with the Weather Research and Forecasting (WRF) model. The purpose of the investigation is to assess the impact on forecast skill in response to assimilation of the Atmospheric Infrared Sounder (AIRS) clear-sky and cloud-cleared radiances over the Indian region. This is the first study that makes use of cloud-cleared radiances in the WRF system. Two sets of thirty-one 72 h forecasts are performed, all initialized at 00:00 UTC each day throughout the month of July 2010, to compare the model performance consequent to assimilation of clear-sky versus cloud-cleared radiances. A rigorous validation is produced against National Centers for Environmental Prediction analyzed wind, temperature, and moisture. In addition, the precipitation forecast skill is assessed against Tropical Rainfall Measuring Mission observations. The results show improvement in forecast skill consequent to the assimilation of cloud-cleared radiances (CCR). The implications of using CCR for operational weather forecasting appear to be significant. Since only a small fraction of AIRS channels are cloud-free, information obtained in cloudy regions, which is meteorologically very significant, is lost when assimilating only clear-sky radiances (CSR). On the contrary, assimilation of CCR allows a larger yield, which leads to improved model performance. The assimilation of CCR resulted in significantly improved rainfall prediction compared to that obtained from the use of CSR. The finding of this study clearly shows the advantage of CCR available from clear-sky as well as from partly cloudy regions as compared to CSR, which are available only in clear-sky regions.

  15. Clear-cell melanocytic lesions with balloon-cell and sebocyte-like melanocytes: a unifying concept.

    Science.gov (United States)

    Kazlouskaya, Viktoryia; Guo, Ying; Maia-Cohen, Sandra; Mones, Joan

    2014-05-01

    Melanocytes may assume unique shapes and sizes but rarely have clear cytoplasm. We studied 28 melanocytic lesions that contained clear-cell melanocytes of the balloon-cell and sebocyte-like types. Clear-cell melanocytes were found more commonly in females (64%) than in males (36%), with predominance in females younger than 50 years (79%) and predominance in males older than 50 years (67%). They were distributed evenly throughout the body but were not found on acral sites. Clear-cell melanocytes were most prevalent in congenital nevi (18 or 72%) but were also found in 5 Clark nevi, 2 Meischer nevi, 1 Unna nevus, 1 atypical intra-epidermal proliferation, and 1 melanoma. The clear cells were distributed diffusely in 86% of the lesions and focally in 14%. The overall percentage of clear-cell melanocytes was 56%. The percentage of balloon cells was 57% and sebocyte-like melanocytes 32%. Clear cells with morphologic features of both balloon cells and sebocyte-like melanocytes, that is, intermediate cells, were present in all lesions with an overall percentage of 12%. The presence of melanocytes of both the balloon-cell and sebocyte-like types and the finding of clear-cell melanocytes with intermediate features in all lesions lends support to the theory that balloon-cell and sebocyte-like melanocytes may represent morphologic expressions of the same alteration in melanogenesis.

  16. 77 FR 66209 - Self-Regulatory Organizations; ICE Clear Europe Limited; Notice of Filing of Proposed Rule Change...

    Science.gov (United States)

    2012-11-02

    ... of default of a clearing member that has written credit protection on such a sovereign, the New... credit markets. ICE Clear Europe believes clearance of the New Sovereign Contracts will facilitate the... associated with swap transactions. The terms of the New Sovereign Contracts will be governed by Paragraph...

  17. 76 FR 65763 - Self-Regulatory Organizations; ICE Clear Credit LLC; Order Approving Proposed Rule Change To Add...

    Science.gov (United States)

    2011-10-24

    ..., other than with respect to certain conforming changes. \\4\\ Similar to the index credit default swap... COMMISSION Self-Regulatory Organizations; ICE Clear Credit LLC; Order Approving Proposed Rule Change To Add Rules Related to the Clearing of Emerging Markets Sovereigns October 18, 2011. I. Introduction On...

  18. 78 FR 7844 - Self-Regulatory Organizations; ICE Clear Europe Limited; Notice of Withdrawal of Proposed Rule...

    Science.gov (United States)

    2013-02-04

    ... proposed rule change to provide for the clearing of Western European Sovereign credit default swap contracts on the following sovereign reference entities: Republic of Ireland, Italian Republic, Hellenic... Change To Clear Western European Sovereign CDS Contracts January 29, 2013. On October 15, 2012, ICE...

  19. 78 FR 60357 - Self-Regulatory Organizations; ICE Clear Credit LLC; Notice of Filing of Proposed Rule Change To...

    Science.gov (United States)

    2013-10-01

    ... the basis for ICC to clear additional credit default swap contracts. Specifically, ICC is proposing to... COMMISSION Self-Regulatory Organizations; ICE Clear Credit LLC; Notice of Filing of Proposed Rule Change To Provide for the Clearance of Standard Emerging European and Middle Eastern Sovereign Single...

  20. 76 FR 70206 - Self-Regulatory Organizations; ICE Clear Credit LLC; Notice of Filing of Proposed Rule Change to...

    Science.gov (United States)

    2011-11-10

    ... COMMISSION Self-Regulatory Organizations; ICE Clear Credit LLC; Notice of Filing of Proposed Rule Change to... hereby given that on November 4, 2011, ICE Clear Credit LLC (``ICC'') filed with the Securities and...), the Federal Reserve Bank of New York and the New York State Banking Department. Implementation...