WorldWideScience

Sample records for cleared 510k submissions

  1. 78 FR 14097 - Pulse Oximeters-Premarket Notification Submissions [510(k)s]; Guidance for Industry and Food and...

    Science.gov (United States)

    2013-03-04

    ... Federal Register of July 19, 2007 (72 FR 39631), FDA announced the availability of the draft guidance... HUMAN SERVICES Food and Drug Administration Pulse Oximeters--Premarket Notification Submissions... availability of the guidance entitled ``Pulse Oximeters--Premarket Notification Submissions .'' This...

  2. Premarket Notifications (510(k)s)

    Data.gov (United States)

    U.S. Department of Health & Human Services — Medical device manufacturers are required to submit a premarket notification or 510(k) if they intend to introduce a device into commercial distribution for the...

  3. 78 FR 26786 - 510(k) Device Modifications: Deciding When To Submit a 510(k) for a Change to an Existing Device...

    Science.gov (United States)

    2013-05-08

    ... management in the decision process on whether a medical device modification requires a new 510(k) submission... management into this decision process in a way that ensures appropriate and consistent modification decisions... and resolve the following concerns. 1. Risk Management is a Process--Published risk...

  4. 75 FR 4402 - Strengthening the Center for Devices and Radiological Health's 510(k) Review Process; Public...

    Science.gov (United States)

    2010-01-27

    ... requirement), that the device meets the comparative standard of ``substantial equivalence'' to a ``predicate... about devices that have been cleared for marketing through the 510(k) process. Currently, if a device... different ``intended uses'' and explain your reasoning. b. What are the advantages and disadvantages...

  5. Specific heat of rhenium disulfide in 360-510 K temperature range

    International Nuclear Information System (INIS)

    Isobaric specific heat of rhenium disulfide was measured by the method of differential scanning calorimetry in the range of 360-510 K. Thermodynamic functions of rhenium disulfide were calculated using literature data on standard entropy of the compound for the range of 296.15-600 K. 3 refs., 1 fig., 2 tabs

  6. 75 FR 47307 - Center for Devices and Radiological Health 510(k) Working Group Preliminary Report and...

    Science.gov (United States)

    2010-08-05

    ... HUMAN SERVICES Food and Drug Administration Center for Devices and Radiological Health 510(k) Working... ``Center for Devices and Radiological Health Preliminary Internal Evaluations,'' which is comprised of the... public input on the recommendations discussed in these reports, including the feasibility...

  7. Fixing a 510(K) Loophole: In Support of The Sound Devices Act of 2012

    OpenAIRE

    Ho, Shuenn (Patrick)

    2014-01-01

    The current medical device regulatory system contains a dangerous loophole. While the voluntary recall of a harmful medical device removes it from the market, new devices that claim they are substantially equivalent to the recalled device can still reach the market through the 510(k) premarket notification process. Devices that have gained regulatory clearance in this fashion have caused considerable harm and are much more likely to be recalled for safety reasons as well. The recently propo...

  8. 78 FR 100 - Guidance for Industry and Food and Drug Administration Staff; Refuse To Accept Policy for 510(k)s...

    Science.gov (United States)

    2013-01-02

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry and Food and Drug Administration Staff; Refuse To Accept Policy for 510(k)s; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of the...

  9. 21 CFR 880.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act). 880.9 Section 880.9 Food and Drugs FOOD AND DRUG... Food, Drug, and Cosmetic Act (the act). The exemption from the requirement of premarket...

  10. 21 CFR 884.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act). 884.9 Section 884.9 Food and Drugs FOOD AND DRUG..., and Cosmetic Act (the act). The exemption from the requirement of premarket notification (section...

  11. 75 FR 82489 - Process for Submissions for Review of Security-Based Swaps for Mandatory Clearing and Notice...

    Science.gov (United States)

    2010-12-30

    ... a CCP for securities transactions is a clearing agency as defined in the Exchange Act and is... methods: Electronic Comments Use the Commission's Internet comment form( http://www.sec.gov/rules/proposed...-based swaps, for the purpose of including transactions and entities that have been structured to...

  12. SNOW CLEARING

    CERN Multimedia

    Groupe de Transport/Transport Group

    1999-01-01

    In order to facilitate snow-clearing operations, which commence at 4.30 every morning, drivers of CERN vehicles are kindly requested to group their cars together in the car parks. This will greatly help us in our work. Thank you for your co-operation.Transport Group / ST-HMTel. 72202

  13. Clearing, transparency, and collateral

    OpenAIRE

    Francesco Carli; Francesca Carapella; Gaetano Antinolfi

    2014-01-01

    In an environment of Over-The-Counter trading with adverse selection we study traders' incentives to screen their counterparties under different clearing arrangements. When the clearing arrangement is also a choice, traders decide which types of transactions to clear under each arrangement, with signicant consequences for transparency and collateral requirements. The key trade-off is between insurance and the value of information: on one hand risk averse traders want to smooth consumption and...

  14. Clear cell chondrosarcoma

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, R.; David, R.; Cierney, G. III

    1985-01-01

    The clinical, radiologic, and histopathologic features of three cases of clear cell chondrosarcoma are described. On radiographs, this rather benign-appearing tumor resembles a chondroblastoma when it occurs at the end of a long bone, and may occasionally show a calcified matrix. However, it has distinctive tumor cells with a centrally placed vesicular nucleus surrounded by clear cytoplasm. The lesion has a low-grade malignancy and is amenable to en bloc surgical resection, which results in a much better prognosis than that of conventional chondrosarcoma.

  15. Snow-clearing operations

    CERN Document Server

    EN Department

    2010-01-01

    To facilitate snow clearing operations, which commence at 4.30 in the morning, all drivers of CERN cars are kindly requested to park them together in groups. This will help us greatly assist us in our work. Thank-you for your help. Transport Group / EN-HE Tel. 72202

  16. Clearing the Big Smog

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Beijing is trying to clean up its sky with a new standard for vehicle emissions From March 1,Beijing has imple- mented a new stricter vehicle emission standard that could lead to cleaner air,but also force thousands of cars off the road. StandardⅣ,the latest in a series of measures aimed at clearing the per- sistent smog,will match the current standard of the European Union. All the new light petro vehicles that are on sale in the Beijing market shall

  17. To Clear or Not To Clear - That Is the Question

    OpenAIRE

    Downing, Adam; Childs, Corey; Porr, C. A. Shea

    2009-01-01

    Many options exist if you do decide to clear land. Regardless of the option you choose, the primary goal should be the same: to minimize soil loss and movement during and immediately after the land clearing process.

  18. Instructions for Submissions

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    <正>Asian Agricultural Research, as a monthly academic journal, is mainly engaged in research and discussion of agricultural economic issues. Papers on this topic will be preferred. Other topics may touch upon farmers, rural development, rural environment, rural public goods, land science, etc. Submission in electronic form is preferred, including Portable Document Format (pdf) and MS-Word (doc). If you submit

  19. Media Language, Clear or Obscure

    DEFF Research Database (Denmark)

    Jakobsen, Bjarne le Fevre; Ejstrup, Michael

    2015-01-01

    Abstract— Be clear, not obscure. One of the four maxims for optimal communication is that it is essential to develop proficiency in being concise and clear. The question is whether this is really a good idea in all contexts. There is some evidence to the contrary. Undoubtedly, we have many contex...

  20. Media Language, Clear or Obscure

    DEFF Research Database (Denmark)

    Ejstrup, Michael; le Fevre Jakobsen, Bjarne

    2015-01-01

    Be clear, not obscure. One of the four maxims for optimal communication is that it is essential to develop proficiency in being concise and clear. The question is whether this is really a good idea in all contexts. There is some evidence to the contrary. Undoubtedly, we have many contexts where i...

  1. 77 FR 73103 - Self-Regulatory Organizations; ICE Clear Credit LLC; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2012-12-07

    ... Rules. Section 17A(b)(3)(F) of the Act \\5\\ requires, among other things, that the rules of a clearing... Internet comment form ( http://www.sec.gov/rules/sro.shtml ); or Send an email to rule-comments@sec.gov... Commission's Internet Web site ( http://www.sec.gov/rules/sro.shtml ). Copies of the submission,...

  2. Plain Language Clear and Simple.

    Science.gov (United States)

    National Literacy Secretariat, Ottawa (Ontario).

    Written for Canadian public servants and written with their help, this handbook presents principles and tips to make official writing clear, concise, and well organized. The handbook defines "plain language" writing as a technique of organizing information in ways that make sense to the reader--using familiar, straightforward words. The handbook…

  3. The art of thinking clearly

    CERN Document Server

    Dobelli, Rolf

    2013-01-01

    The Art of Thinking Clearly by world-class thinker and entrepreneur Rolf Dobelli is an eye-opening look at human psychology and reasoning — essential reading for anyone who wants to avoid “cognitive errors” and make better choices in all aspects of their lives. Have you ever: Invested time in something that, with hindsight, just wasn’t worth it? Or continued doing something you knew was bad for you? These are examples of cognitive biases, simple errors we all make in our day-to-day thinking. But by knowing what they are and how to spot them, we can avoid them and make better decisions. Simple, clear, and always surprising, this indispensable book will change the way you think and transform your decision-making—work, at home, every day. It reveals, in 99 short chapters, the most common errors of judgment, and how to avoid them.

  4. Central Clearing of OTC Derivatives

    DEFF Research Database (Denmark)

    Cont, Rama; Kokholm, Thomas

    2014-01-01

    We study the impact of central clearing of over-the-counter (OTC) transactions on counterparty exposures in a market with OTC transactions across several asset classes with heterogeneous characteristics. The impact of introducing a central counterparty (CCP) on expected interdealer exposure...... is determined by the tradeoff between multilateral netting across dealers on one hand and bilateral netting across asset classes on the other hand. We find this tradeoff to be sensitive to assumptions on heterogeneity of asset classes in terms of `riskyness' of the asset class as well as correlation...... of exposures across asset classes. In particular, while an analysis assuming independent, homogeneous exposures suggests that central clearing is efficient only if one has an unrealistically high number of participants, the opposite conclusion is reached if differences in riskyness and correlation across asset...

  5. Writing clear animal activity proposals.

    Science.gov (United States)

    Pinson, David M

    2011-06-01

    Although IACUC-related topics are frequently discussed in the literature, there is little published information about how to write animal activity proposals. In this article, the author discusses key considerations in the writing and review of animal activity proposals. The author then describes a framework for developing and writing clear animal activity proposals that highlight animal welfare concerns. Though these recommendations are aimed at individuals writing and reviewing research proposals, the framework can be modified for other types of animal activity proposals.

  6. 77 FR 21277 - Customer Clearing Documentation, Timing of Acceptance for Clearing, and Clearing Member Risk...

    Science.gov (United States)

    2012-04-09

    ...\\ Clearing Member Risk Management, 76 FR 45724 (Aug. 1, 2011). \\7\\ Adaption of Regulations to Incorporate... ``risk management.'' See, e.g., proposed Sec. 39.13 relating to risk management for DCOs, 76 FR at 3720... an important risk mitigant. This time lag potentially presents credit risk to the swap...

  7. 6 CFR 27.210 - Submissions schedule.

    Science.gov (United States)

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Submissions schedule. 27.210 Section 27.210... STANDARDS Chemical Facility Security Program § 27.210 Submissions schedule. (a) Initial Submission. The... Schedule for Covered Facilities. The timeframes in this subsection also apply to covered facilities...

  8. First Responses to Submissions

    DEFF Research Database (Denmark)

    Petersen, Margrethe

    2008-01-01

    The past 20-30 years have seen much scholarly interest in English for academic purposes, be it in the form of academic writing, academic English in general, or the various genres characteristic of academic communication in English. Over the same period of time, researchers at institutions of higher...... of the submission letter", in E. Ventola and A Mauranen (eds): Academic Writing: Intercultural and Textual Issues. John Benjamins, Amsterdam, pp 45-58.  - and C.B. Feak (2000): English in Today's Research World: A Writer's Guide. Michigan University Press, Michigan....... education have faced intensifying pressure to publish internationally in high-ranking academic journals. Nevertheless, there has been little research on the publishing process involved. One notable exception is that of Flowerdew and Dudley-Evans (2002), which, on the basis of the genre analysis framework...

  9. Ion clearing in an ERL

    Science.gov (United States)

    Hoffstaetter, Georg H.; Liepe, Matthias

    2006-02-01

    The rest-gas in the beam-pipe of a particle accelerator is readily ionized by effects like collisions, synchrotron radiation and field emission. Positive ions are attracted to electron beams and create a nonlinear potential in the vicinity of the beam which can lead to beam halo, particle loss, optical errors or transverse and longitudinal instabilities. In an energy recovery linac (ERL) where beam-loss has to be minimal, and where beam positions and emittances have to be very stable in time, these ion effects have to be avoided. Here we investigate three measures of avoiding ion accumulation: (a) A long gap between linac bunch trains that allows ions to drift out of the beam region, a measure regularly applied in linacs; (b) a short ion clearing gap in the beam that leads to a time varying beam potential and produces large excited oscillations of ions around the electron beam, a measure regularly applied in storage rings; (c) Clearing electrodes that create a sufficient voltage to draw ions out of the beam potential, a measure used for DC electron beams and for antiproton beams. For the parameters of the X-ray ERL planned at Cornell University we show that method (a) cannot be applied, method (b) is technically cumbersome, and (c) should be most easily applicable.

  10. Review of submissions: competition impacts

    NARCIS (Netherlands)

    G. Burghouwt; W. de Wit

    2015-01-01

    The Airports Commission requested ITF/SEO to provide technical assistance with analysing responses that pertain to the previous work undertaken by the ITF/SEO. This report assesses the submissions by the stakeholders in relation to competition impacts and compares them with the ITF/SEO results and t

  11. Automatic processing of dominance and submissiveness

    OpenAIRE

    Moors, Agnes; De Houwer, Jan

    2005-01-01

    We investigated whether people are able to detect in a relatively automatic manner the dominant or submissive status of persons engaged in social interactions. Using a variant of the affective Simon task (De Houwer & Eelen, 1998), we demonstrated that the verbal response DOMINANT or SUBMISSIVE was facilitated when it had to be made to a target person that was respectively dominant or submissive. These results provide new information about the automatic nature of appraisals and ...

  12. Automated Data Submission for the Data Center

    Science.gov (United States)

    Wright, D.; Beaty, T.; Wei, Y.; Shanafield, H.; Santhana Vannan, S. K.

    2014-12-01

    Data centers struggle with difficulties related to data submission. Data are acquired through many avenues by many people. Many data submission activities involve intensive manual processes. During the submission process, data end up on varied storage devices. The situation can easily become chaotic. Collecting information on the status of pending data sets is arduous. For data providers, the submission process can be inconsistent and confusing. Scientists generally provide data from previous projects, and archival can be a low priority. Incomplete or poor documentation accompanies many data sets. However, complicated questionnaires deter busy data providers. At the ORNL DAAC, we have semi-automated the data set submission process to create a uniform data product and provide a consistent data provider experience. The formalized workflow makes archival faster for the data center and data set submission easier for data providers. Software modules create a flexible, reusable submission package. Formalized data set submission provides several benefits to the data center. A single data upload area provides one point of entry and ensures data are stored in a consistent location. A central dashboard records pending data set submissions in a single table and simplifies reporting. Flexible role management allows team members to readily coordinate and increases efficiency. Data products and metadata become uniform and easily maintained. As data and metadata standards change, modules can be modified or re-written without affecting workflow. While each data center has unique challenges, the data ingestion process is generally the same: get data from the provider, scientist, or project and capture metadata pertinent to that data. The ORNL DAAC data set submission workflow and software modules can be reused entirely or in part by other data centers looking for a data set submission solution. These data set submission modules will be available on NASA's Earthdata Code

  13. CO2 Efflux from Cleared Mangrove Peat

    OpenAIRE

    Lovelock, Catherine E.; Roger W Ruess; Feller, Ilka C.

    2011-01-01

    BACKGROUND: CO(2) emissions from cleared mangrove areas may be substantial, increasing the costs of continued losses of these ecosystems, particularly in mangroves that have highly organic soils. METHODOLOGY/PRINCIPAL FINDINGS: We measured CO(2) efflux from mangrove soils that had been cleared for up to 20 years on the islands of Twin Cays, Belize. We also disturbed these cleared peat soils to assess what disturbance of soils after clearing may have on CO(2) efflux. CO(2) efflux from soils de...

  14. 40 CFR 68.150 - Submission.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Submission. 68.150 Section 68.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.150 Submission. (a) The owner or operator...

  15. 7 CFR 4284.7 - Electronic submission.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Electronic submission. 4284.7 Section 4284.7 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND... Grant Programs § 4284.7 Electronic submission. Applicants and grant awardees are encouraged, but...

  16. 28 CFR 51.22 - Premature submissions.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Premature submissions. 51.22 Section 51.22 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROCEDURES FOR THE ADMINISTRATION OF... § 51.22 Premature submissions. The Attorney General will not consider on the merits: (a) Any...

  17. 27 CFR 9.99 - Clear Lake.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Clear Lake. 9.99 Section 9... TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.99 Clear Lake. (a) Name. The name of the viticultural area described in this section is “Clear Lake.” (b) Approved...

  18. 77 FR 66219 - Clearing Agency Standards

    Science.gov (United States)

    2012-11-02

    ... to clear credit default swaps. See Exchange Act Release Nos. 60372 (July 23, 2009), 74 FR 37748 (July 29, 2009), 61973 (Apr. 23, 2010), 75 FR 22656 (Apr. 29, 2010) and 63389 (Nov. 29, 2010), 75 FR 75520 (Dec. 3, 2010) (CDS clearing by ICE Clear Europe Limited); 60373 (July 23, 2009), 74 FR 37740 (July...

  19. 76 FR 45724 - Clearing Member Risk Management

    Science.gov (United States)

    2011-08-01

    ... COMMISSION 17 CFR Parts 1 and 23 RIN 3038-AD51 Clearing Member Risk Management AGENCY: Commodity Futures... extensive regulations addressing open access and risk management at the derivatives clearing organization (DCO) level.\\4\\ The Commission also has proposed regulations addressing risk management for...

  20. Internalization, Clearing and Settlement, and Liquidity

    NARCIS (Netherlands)

    Degryse, H.A.; van Achter, M.; Wuyts, G.

    2012-01-01

    Abstract: We study the relation between liquidity in financial markets and post-trading fees (i.e. clearing and settlement fees). The clearing and settlement agent (CSD) faces different marginal costs for different types of transactions. Costs are lower for an internalized transaction, i.e. when buy

  1. 17 CFR 39.4 - Procedures for implementing derivatives clearing organization rules and clearing new products.

    Science.gov (United States)

    2010-04-01

    ... product until its registration as a derivatives clearing organization is reinstated under the procedures... clearing a new product that is not traded on a designated contract market or a registered derivatives... of the product that make it acceptable for clearing with a certification that the clearing of...

  2. SNOW CLEARING SERVICE WINTER 2001-2002

    CERN Multimedia

    ST-HM Group; Tel. 72202

    2001-01-01

    As usual at this time of the year, the snowing clearing service, which comes under the control of the Transport Group (ST-HM), is preparing for the start of snow-clearing operations (timetable, stand-by service, personnel responsible for driving vehicles and machines, preparation of useful and necessary equipment, work instructions, etc.) in collaboration with the Cleaning Service (ST-TFM) and the Fire Brigade (TIS-FB). The main difficulty for the snow-clearing service is the car parks, which cannot be properly cleared because of the presence of CERN and private vehicles parked there overnight in different parts of the parking areas. The ST-HM Transport Group would therefore like to invite you to park vehicles together in order to facilitate the access of the snow ploughs, thus allowing the car parks to be cleared more efficiently before the personnel arrives for work in the mornings.

  3. DOMINANCE OF EXISTENCE: RIOT OR SUBMISSION

    Directory of Open Access Journals (Sweden)

    Vasiljeva A. S.

    2014-03-01

    Full Text Available This article investigates two types of self-actualization and the search for meaning in terms of the totality of existence. The conditions and forms of rebellion and submission are also listed

  4. 75 FR 12803 - Fingerprint Submission Requirements Rule

    Science.gov (United States)

    2010-03-17

    ...Notice of the Compact Council's establishment of a process for initiating noncriminal justice criminal history record checks during times of emergencies and disasters under the authority of the Fingerprint Submission Requirements Rule, title 28 Code of Federal Regulations (CFR), part...

  5. 76 FR 62421 - Submission for OMB Review; Comment Request; A Generic Submission for Theory Development and...

    Science.gov (United States)

    2011-10-07

    ... Generic Submission for Theory Development and Validation (NCI). Type of Information Collection Request... Submission for Theory Development and Validation (NCI) SUMMARY: Under the provisions of Section 3507(a)(1)(D... approval of the information collection listed below. This proposed information collection was...

  6. 76 FR 11498 - Submission for OMB Review; Comment Request; Generic Submission of Technology Transfer Center (TTC...

    Science.gov (United States)

    2011-03-02

    ... Submission of Technology Transfer Center (TTC) External Customer Satisfaction Surveys (NCI) SUMMARY: Under... information collection was previously published in the Federal Register on December 23, 2010 (75 FR 80830) and... control number. Proposed Collection: Title: Generic Submission of Technology Transfer Center...

  7. 77 FR 1472 - Submission of Data by State Educational Agencies; Submission Dates for State Revenue and...

    Science.gov (United States)

    2012-01-10

    ... data will be published by NCES and will be used by the Secretary in the calculation of allocations for... funds based on the best, most accurate data available, NCES establishes, for allocation purposes, August... Submission of Data by State Educational Agencies; Submission Dates for State Revenue and Expenditure...

  8. High Altitude Clear Air Turbulence Project

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Air Force Flight Dynamics Laboratory conducted the High Altitude Clear Air Turbulence Project in the mid 1960s with the intention of better understanding air...

  9. Ion clearing the the XLS-ring

    Energy Technology Data Exchange (ETDEWEB)

    Bozoki, E.S.; Halama, H.

    1990-01-01

    The mechanism of ion capture by the beam, their effects on the beam as well as ways to clear the ions are discussed. Special attention is given to these questions for the SXLS ring. 20 refs., 5 figs., 4 tabs.

  10. Ion clearing the the XLS-ring

    International Nuclear Information System (INIS)

    The mechanism of ion capture by the beam, their effects on the beam as well as ways to clear the ions are discussed. Special attention is given to these questions for the SXLS ring. 20 refs., 5 figs., 4 tabs

  11. komunikace značky Clean & Clear

    OpenAIRE

    Nováková, Kateřina

    2009-01-01

    The objective of this thesis is to describe a communication campaign of Clean & Clear brand. A brand owned by Johnson & Johnson company specializing in cosmetics for teenage girls. Campaign is described into details, evaluated in terms of effectiveness of its communication tools by achieving marketing goals over a specified period of time. This thesis should confirm the suitability and effectivity of the communication mix applied for Clean & Clear brand in a specific enviroment of anti-acne c...

  12. Governance of securities clearing and settlement systems

    OpenAIRE

    Daniela Russo; Terry L. Hart; Chryssa Papathanassiou

    2004-01-01

    In the context of securities clearing and settlement systems, the nature of governance arrangements acquires a dimension that goes beyond their traditional function in corporate law. They constitute a tool for regulators and central banks to achieve their respective policy goals relating to market operation, market integrity, and systemic stability. In the light of the analysis of this paper, and pending a further evolution in the regulation of securities clearing and settlement in the Commun...

  13. Skin optical clearing potential of disaccharides.

    Science.gov (United States)

    Feng, Wei; Shi, Rui; Ma, Ning; Tuchina, Daria K; Tuchin, Valery V; Zhu, Dan

    2016-08-01

    Skin optical clearing can significantly enhance the ability of biomedical optical imaging. Some alcohols and sugars have been selected to be optical clearing agents (OCAs). In this work, we paid attention to the optical clearing potential of disaccharides. Sucrose and maltose were chosen as typical disaccharides to compare with fructose, an excellent monosaccharide-OCA, by using molecular dynamics simulation and an ex vivo experiment. The experimental results indicated that the optical clearing efficacy of skin increases linearly with the concentration for each OCA. Both the theoretical predication and experimental results revealed that the two disaccharides exerted a better optical clearing potential than fructose at the same concentration, and sucrose is optimal. Since maltose has an extremely low saturation concentration, the other two OCAs with saturation concentrations were treated topically on rat skin in vivo, and optical coherence tomography imaging was applied to monitor the optical clearing process. The results demonstrated that sucrose could cause a more significant increase in imaging depth and signal intensity than fructose. PMID:27108771

  14. CO2 efflux from cleared mangrove peat.

    Directory of Open Access Journals (Sweden)

    Catherine E Lovelock

    Full Text Available BACKGROUND: CO(2 emissions from cleared mangrove areas may be substantial, increasing the costs of continued losses of these ecosystems, particularly in mangroves that have highly organic soils. METHODOLOGY/PRINCIPAL FINDINGS: We measured CO(2 efflux from mangrove soils that had been cleared for up to 20 years on the islands of Twin Cays, Belize. We also disturbed these cleared peat soils to assess what disturbance of soils after clearing may have on CO(2 efflux. CO(2 efflux from soils declines from time of clearing from ∼10,600 tonnes km(-2 year(-1 in the first year to 3000 tonnes km(2 year(-1 after 20 years since clearing. Disturbing peat leads to short term increases in CO(2 efflux (27 umol m(-2 s(-1, but this had returned to baseline levels within 2 days. CONCLUSIONS/SIGNIFICANCE: Deforesting mangroves that grow on peat soils results in CO(2 emissions that are comparable to rates estimated for peat collapse in other tropical ecosystems. Preventing deforestation presents an opportunity for countries to benefit from carbon payments for preservation of threatened carbon stocks.

  15. 76 FR 50230 - Center for Devices and Radiological Health 510(k) Clearance Process; Recommendations Proposed in...

    Science.gov (United States)

    2011-08-12

    ... August 5, 2010 (75 FR 47307). After reviewing public comment, CDRH issued a plan of action for... public meeting will be held at the Silver Spring Hilton Hotel, 8727 Colesville Rd., Silver Spring, MD... inhibiting innovation in the medical device industry. 7. FDA should develop procedures that ensure the...

  16. 21 CFR 807.93 - Content and format of a 510(k) statement.

    Science.gov (United States)

    2010-04-01

    ... identifiers, and trade secret and confidential commercial information, as defined in 21 CFR 20.61. (2) The... (CONTINUED) MEDICAL DEVICES ESTABLISHMENT REGISTRATION AND DEVICE LISTING FOR MANUFACTURERS AND INITIAL... patient identifiers, and trade secret and confidential commercial information as defined in § 20.61...

  17. 76 FR 47529 - Customer Clearing Documentation and Timing of Acceptance for Clearing; Correction

    Science.gov (United States)

    2011-08-05

    ... Street, NW., Washington, DC 20581. SUPPLEMENTARY INFORMATION: In FR Doc. 2011-19365 appearing on page... COMMISSION 17 CFR Parts 1, 23, and 39 RIN 3038-AD51 Customer Clearing Documentation and Timing of Acceptance... August 1, 2011, regarding Customer Clearing Documentation and Timing of Acceptance for Clearing....

  18. Shanghai Clearing House to Roll out Renminbi-denominated Copper Clearing Operations in Free Trade Zone

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    <正>Clearing House Financial Markets Co.,Ltd.(Shanghai Clearing House)General Manager Xie Zhong told the media recently at the briefing of the international symposium of"Reform Deepening and Mechanism Innovation of the Post-crisis Kerb Market",Shanghai Clearing House will explore the feasibility of carrying out bond business in

  19. Clear plastic cups: a childhood choking hazard.

    Science.gov (United States)

    Weiss, R L; Goldstein, M N; Dharia, A; Zahtz, G; Abramson, A L; Patel, M

    1996-11-01

    The disposable plastic beverage cup is not usually regarded as hazardous to young children. Certain varieties of these products however, are manufactured from a brittle, clear plastic that easily cracks and fragments. While most conscientious parents keep their children safe from peanuts, balloons, and other known choking hazards, a child can surreptitiously bite a cup edge and aspirate the fragment. We report two cases of foreign body aspiration involving clear plastic cups that went undetected one of which remained 21 months following a negative rigid bronchoscopy. Diagnostic difficulties are related to the transparency and radiolucency of these objects. When suspicious of foreign body aspiration in children, otolaryngologists should inquire about the availability of clear plastic cups in the household and be mindful of the diagnostic pitfalls. Further investigations including CT scanning and repeat bronchoscopy may be helpful in cases of suspected missed foreign bodies. An educational campaign aimed at prevention and placement of product package warning labels should be established.

  20. The debts' clearing problem: a new approach

    CERN Document Server

    Pătcaş, C

    2011-01-01

    The debts' clearing problem is about clearing all the debts in a group of $n$ entities (e.g. persons, companies) using a minimal number of money transaction operations. In our previous works we studied the problem, gave a dynamic programming solution solving it and proved that it is NP-hard. In this paper we adapt the problem to dynamic graphs and give a data structure to solve it. Based on this data structure we develop a new algorithm, that improves our previous one for the static version of the problem.

  1. Oral Cavity Clear Cell Odontogenic Carcinoma.

    Science.gov (United States)

    Ginat, Daniel Thomas; Villaflor, Victoria; Cipriani, Nicole A

    2016-06-01

    A case of clear cell odontogenic carcinoma of the oral cavity is described in this sine qua non radiology-pathology correlation article. CT demonstrated a solid and cystic mass arising from the mandible. Histology demonstrated variably-sized nests of clear to pale eosinophilic cells with occasional central necrosis embedded in a hyalinized to fibrocellular stroma. The specimen was also positive for the characteristic rearrangement of the EWSR1 (22q12) locus in 93.5 % of interphase cells. PMID:25994920

  2. Clear cell carcinoma of the female genital tract (not everything is as clear as it seems).

    Science.gov (United States)

    Offman, Saul L; Longacre, Teri A

    2012-09-01

    Clear cell carcinoma has a storied history in the female genital tract. From the initial designation of ovarian clear cell adenocarcinoma as "mesonephroma" to the linkage between vaginal clear cell carcinoma and diethylstilbestrol exposure in utero, gynecologic tract clear cell tumors have puzzled investigators, posed therapeutic dilemmas for oncologists, and otherwise presented major differential diagnostic challenges for pathologists. One of the most common errors in gynecologic pathology is misdiagnosis of clear cell carcinoma, on both frozen section and permanent section. Given the poor response to platinum-based chemotherapy for advanced-stage disease and increased risk of thromboembolism, accurate diagnosis of clear cell carcinoma is important in the female genital tract. This review (1) presents the clinical and pathologic features of female genital tract clear cell carcinomas; (2) highlights recent molecular developments; (3) identifies areas of potential diagnostic confusion; and (4) presents solutions for these diagnostic problems where they exist.

  3. The management of clear cell sarcoma

    NARCIS (Netherlands)

    Kuiper, DR; Hoekstra, HJ; Veth, RPH; Wobbes, T

    2003-01-01

    Clear cell sarcoma is a rare soft tissue tumour, constituting approximately 1% of all soft tissue sarcomas. Prognosis is reported to be poor due to the great propensity to metastasise regionally and distantly. In this paper, we report the surgical experience of two university hospitals. Both disease

  4. Lake Mead--clear and vital

    Science.gov (United States)

    Wessells, Stephen M.; Rosen, Michael

    2013-01-01

    “Lake Mead – Clear and Vital” is a 13 minute documentary relating the crucial role of science in maintaining high water quality in Lake Mead. The program was produced coincident with release of the Lakes Mead and Mohave Circular a USGS publication covering past and on-going research in the lakes and tributaries of the Lake Mead National Recreation Area.

  5. Identifying multiple submissions in Internet research: preserving data integrity.

    Science.gov (United States)

    Bowen, Anne M; Daniel, Candice M; Williams, Mark L; Baird, Grayson L

    2008-11-01

    Internet-based sexuality research with hidden populations has become increasingly popular. Respondent anonymity may encourage participation and lower social desirability, but associated disinhibition may promote multiple submissions, especially when incentives are offered. The goal of this study was to identify the usefulness of different variables for detecting multiple submissions from repeat responders and to explore incentive effects. The data included 1,900 submissions from a three-session Internet intervention with a pretest and three post-test questionnaires. Participants were men who have sex with men and incentives were offered to rural participants for completing each questionnaire. The final number of submissions included 1,273 "unique", 132 first submissions by "repeat responders" and 495 additional submissions by the "repeat responders" (N = 1,900). Four categories of repeat responders were identified: "infrequent" (2-5 submissions), "persistent" (6-10 submissions), "very persistent" (11-30 submissions), and "hackers" (more than 30 submissions). Internet Provider (IP) addresses, user names, and passwords were the most useful for identifying "infrequent" repeat responders. "Hackers" often varied their IP address and identifying information to prevent easy identification, but investigating the data for small variations in IP, using reverse telephone look up, and patterns across usernames and passwords were helpful. Incentives appeared to play a role in stimulating multiple submissions, especially from the more sophisticated "hackers". Finally, the web is ever evolving and it will be necessary to have good programmers and staff who evolve as fast as "hackers". PMID:18240015

  6. Roadmap-Based Level Clearing of Buildings

    KAUST Repository

    Rodriguez, Samuel

    2011-01-01

    In this paper we describe a roadmap-based approach for a multi-agent search strategy to clear a building or multi-story environment. This approach utilizes an encoding of the environment in the form of a graph (roadmap) that is used to encode feasible paths through the environment. The roadmap is partitioned into regions, e.g., one per level, and we design region-based search strategies to cover and clear the environment. We can provide certain guarantees within this roadmap-based framework on coverage and the number of agents needed. Our approach can handle complex and realistic environments where many approaches are restricted to simple 2D environments. © 2011 Springer-Verlag.

  7. Multiphoton microscopy of cleared mouse organs

    Science.gov (United States)

    Parra, Sonia G.; Chia, Thomas H.; Zinter, Joseph P.; Levene, Michael J.

    2010-05-01

    Typical imaging depths with multiphoton microscopy (MPM) are limited to less than 300 μm in many tissues due to light scattering. Optical clearing significantly reduces light scattering by replacing water in the organ tissue with a fluid having a similar index of refraction to that of proteins. We demonstrate MPM of intact, fixed, cleared mouse organs with penetration depths and fields of view in excess of 2 mm. MPM enables the creation of large 3-D data sets with flexibility in pixel format and ready access to intrinsic fluorescence and second-harmonic generation. We present high-resolution images and 3-D image stacks of the brain, small intestine, large intestine, kidney, lung, and testicle with image sizes as large as 4096×4096 pixels.

  8. Internet compromise clears way for WSIS agreement

    CERN Multimedia

    Ermert, M

    2003-01-01

    A working group under the leadership of United Nations Secretary General Kofi Annan himself will try to resolve the deep differences on the question of Internet governance, officials said here. The group, whose exact membership wasn't immediately clear, is to propose a solution to the controversial issue that has given negotiators at the World Summit of the Information Society (WSIS) a headache (1/2 page).

  9. Rapid radiative clearing of protoplanetary discs

    CERN Document Server

    Haworth, Thomas J; Owen, James E

    2015-01-01

    The lack of observed transition discs with inner gas holes of radii greater than ~50AU implies that protoplanetary discs dispersed from the inside out must remove gas from the outer regions rapidly. We investigate the role of photoevaporation in the final clearing of gas from low mass discs with inner holes. In particular, we study the so-called "thermal sweeping" mechanism which results in rapid clearing of the disc. Thermal sweeping was originally thought to arise when the radial and vertical pressure scale lengths at the X-ray heated inner edge of the disc match. We demonstrate that this criterion is not fundamental. Rather, thermal sweeping occurs when the pressure maximum at the inner edge of the dust heated disc falls below the maximum possible pressure of X-ray heated gas (which depends on the local X-ray flux). We derive new critical peak volume and surface density estimates for rapid radiative clearing which, in general, result in rapid dispersal happening less readily than in previous estimates. Thi...

  10. Nitrous oxide flux following tropical land clearing

    Science.gov (United States)

    Luizao, Flavio; Luizao, Regina; Matson, Pamela; Livingston, Gerald; Vitousek, Peter

    1989-01-01

    The importance of seasonal cycles of N2O flux from tropical ecosystems and the possibility that tropical deforestation could contribute to the ongoing global increase in N2O concentrations were assessed by measuring N2O flux from forest, cleared land, and pasture over an annual cycle in the central Amazon. A pasture that had been converted from tropical forest had threefold greater annual N2O flux than a paired forest site; similar results were obtained in spot measurements in other pastures. If these results are general, such tropical pastures represent a globally significant source of increased N2O.

  11. CHINA'S WORST OIL LEAK CLEARED EXPENSIVELY

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ Eight days and nights of clean-up efforts after the worst oil leak ever in Chinese waters, the aftermath of a collision between two foreign ships happening at 9:35 pm on December 7 about 8 nautical miles away from the mouth of the Pearl River and near the Danjiang Island, have finally paid off. So far, hundreds of tons of waste oil and polluted water have been cleared up. A large area of oil spills has been cleaned thanks to the prompt and proper operation launched just two hours after the accident.

  12. Greenhouse problem in the Amazon jungle clearing

    International Nuclear Information System (INIS)

    This paper discusses the contribution of Amazon jungle clearing to the greenhouse problem and makes an assessment of long-run prospects. The introductory sections pose the problem from both international and Brazilian perspectives. The next section describes major features of the Amazonia ecosystems and presents methods and evidence on deforestation and on its impact on carbon dioxide emissions. Based upon cross-section information for a sample of municipalities in the Brazilian Amazon, the following section estimates elasticities of deforestation in relation to major economic factors- government policies included- and uses them to make projections for the future pace of deforestation. The last section discusses policy alternatives to slow down forest conversion

  13. PLANETARY CHAOTIC ZONE CLEARING: DESTINATIONS AND TIMESCALES

    Energy Technology Data Exchange (ETDEWEB)

    Morrison, Sarah; Malhotra, Renu [Lunar and Planetary Laboratory, The University of Arizona, Tucson, AZ 85721 (United States)

    2015-01-20

    We investigate the orbital evolution of particles in a planet's chaotic zone to determine their final destinations and their timescales of clearing. There are four possible final states of chaotic particles: collision with the planet, collision with the star, escape, or bounded but non-collision orbits. In our investigations, within the framework of the planar circular restricted three body problem for planet-star mass ratio μ in the range 10{sup –9} to 10{sup –1.5}, we find no particles hitting the star. The relative frequencies of escape and collision with the planet are not scale-free, as they depend upon the size of the planet. For planet radius R{sub p} ≥ 0.001 R{sub H} where R{sub H} is the planet's Hill radius, we find that most chaotic zone particles collide with the planet for μ ≲ 10{sup –5}; particle scattering to large distances is significant only for higher mass planets. For fixed ratio R{sub p} /R{sub H} , the particle clearing timescale, T {sub cl}, has a broken power-law dependence on μ. A shallower power law, T {sub cl} ∼ μ{sup –1/3}, prevails at small μ where particles are cleared primarily by collisions with the planet; a steeper power law, T {sub cl} ∼ μ{sup –3/2}, prevails at larger μ where scattering dominates the particle loss. In the limit of vanishing planet radius, we find T {sub cl} ≈ 0.024 μ{sup –3/2}. The interior and exterior boundaries of the annular zone in which chaotic particles are cleared are increasingly asymmetric about the planet's orbit for larger planet masses; the inner boundary coincides well with the classical first order resonance overlap zone, Δa {sub cl,} {sub int} ≅ 1.2 μ{sup 0.28} a{sub p} ; the outer boundary is better described by Δa {sub cl,} {sub ext} ≅ 1.7 μ{sup 0.31} a{sub p} , where a{sub p} is the planet-star separation.

  14. A gap clearing kicker for Main Injector

    CERN Document Server

    Kourbanis, I; Biggs, J; Brown, B; Capista, D; Jensen, C C; Krafczyk, G E; Morris, D K; Scott, D; Seiya, K; Ward, S R; Wu, G; Yang, M -J

    2012-01-01

    Fermilab Main Injector has been operating at high Beam Power levels since 2008 when multi-batch slip stacking became operational. In order to maintain and increase the beam power levels the localized beam loss due to beam left over in the injection kicker gap during slip stacking needs to be addressed. A set of gap clearing kickers that kick any beam left in the injection gap to the beam abort have been built. The kickers were installed in the summer of 2009 and became operational in November of 2010. The kicker performance and its effect on the beam losses will be described.

  15. 77 FR 76809 - Submission of Itineraries

    Science.gov (United States)

    2012-12-31

    ... regulations is to ensure that true traveling exhibitors such as carnivals, circuses, animal acts, traveling... / Monday, December 31, 2012 / Rules and Regulations#0;#0; ] DEPARTMENT OF AGRICULTURE Animal and Plant Health Inspection Service 9 CFR Part 2 RIN 0579-AD03 Submission of Itineraries AGENCY: Animal and...

  16. 76 FR 38219 - Submission for OMB Review

    Science.gov (United States)

    2011-06-29

    ... From the Federal Register Online via the Government Publishing Office OVERSEAS PRIVATE INVESTMENT CORPORATION Submission for OMB Review AGENCY: Overseas Private Investment Corporation (OPIC). ACTION: Request...), agencies are required to publish a Notice in the Federal Register notifying the public that the agency...

  17. 76 FR 38220 - Submission for OMB Review

    Science.gov (United States)

    2011-06-29

    ... From the Federal Register Online via the Government Publishing Office OVERSEAS PRIVATE INVESTMENT CORPORATION Submission for OMB Review AGENCY: Overseas Private Investment Corporation (OPIC). ACTION: Request...), agencies are required to publish a Notice in the Federal Register notifying the public that the agency...

  18. 77 FR 60160 - Submission for OMB Review

    Science.gov (United States)

    2012-10-02

    ... From the Federal Register Online via the Government Publishing Office OVERSEAS PRIVATE INVESTMENT CORPORATION Submission for OMB Review AGENCY: Overseas Private Investment Corporation (OPIC). ACTION: Request...), agencies are required to publish a Notice in the Federal Register notifying the public that the agency...

  19. 76 FR 38221 - Submission for OMB Review

    Science.gov (United States)

    2011-06-29

    ... From the Federal Register Online via the Government Publishing Office OVERSEAS PRIVATE INVESTMENT CORPORATION Submission for OMB Review AGENCY: Overseas Private Investment Corporation (OPIC). ACTION: Request...), agencies are required to publish a Notice in the Federal Register notifying the public that the agency...

  20. 77 FR 33497 - Submission for OMB Review

    Science.gov (United States)

    2012-06-06

    ... From the Federal Register Online via the Government Publishing Office OVERSEAS PRIVATE INVESTMENT CORPORATION Submission for OMB Review AGENCY: Overseas Private Investment Corporation (OPIC). ACTION: Request...), agencies are required to publish a Notice in the Federal Register notifying the public that the agency...

  1. 40 CFR 725.27 - Submissions.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Submissions. 725.27 Section 725.27 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT REPORTING.... (c) Requirements specific to test marketing exemptions (TMEs) are described in §§ 725.350 and...

  2. 42 CFR 426.130 - Party submissions.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Party submissions. 426.130 Section 426.130 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM REVIEW OF NATIONAL COVERAGE DETERMINATIONS AND LOCAL COVERAGE DETERMINATIONS...

  3. Notebook paper: TNO instance search submission 2011

    NARCIS (Netherlands)

    Schavemaker, J.G.M.; Eendebak, P.T.; Staalduinen, M. van; Kraaij, W.

    2011-01-01

    The TNO instance search submission to TRECVID 2011 consisted of three different runs: one is using an exhaustive keypoint search, one is using a bag-of-visual-words approach and one is using open-source face-recognition software. Our run approaches: Briefly, what approach or combination of approache

  4. An unusual case of clear cell meningioma

    Directory of Open Access Journals (Sweden)

    Deb Prabal

    2009-01-01

    Full Text Available Clear-cell meningioma (CCM is an uncommon, aggressive variant of meningioma, usually affecting younger females and having predilection for infratentorial locations. We present a rare case of recurrent supratentorial CCM in a 58-year-old male. Ten years back, he had an intra-axial tumor in the left occipital lobe, which was managed by surgical excision and radiotherapy. Currently, the patient presented with sudden severe headache along with speech and vision disturbances. Neuroimaging revealed an extra-axial parietooccipital tumor, with intratumoural bleed. Histopathology of both tumors showed features of CCM, immunopositive for epithelial membrane antigen (EMA and vimentin. This case illustrates multiple unusual features of a rare variant of meningioma in the form of affection of an adult age group, supratentorial location, recurrence, and intratumoral bleed. It also highlights the importance of incorporating immunohistochemistry in the diagnostic workup, to exclude CCM mimics, each having distinctive biological behavior, and prognostic outcome, and warranting different therapeutic protocols.

  5. Effects Of The Contingency For Homework Submission On Homework Submission And Quiz Performance In A College Course

    OpenAIRE

    Ryan, Carolyn S.; Hemmes, Nancy S.

    2005-01-01

    Effects of the contingency for submission of homework assignments on the probability of assignment submission and on quiz grades were assessed in an undergraduate psychology course. Under an alternating treatments design, each student was assigned to a points condition for 5 of 10 quiz-related homework assignments corresponding to textbook chapters. Points were available for homework submission under this condition; points were not available under the no-points condition. The group-mean perce...

  6. Nuclear threat. A clear and present danger

    International Nuclear Information System (INIS)

    It was disappointed at the discussion in the review conference of the NPT held in 2005. The fact may be caused by the estrangement between the international urgent issues related to the non-proliferation and the effectiveness of archaic measures through the NPT. However, it should not be recognized that the international obligation and worth of NPT has been gone. The NPT referred the typical international situation under the cold war era. Although several permanent issues of the nuclear non-proliferation exist in current discussions, the activities relevant to the NPT may not be effect against newly unstable situations after the September 11th of 2001. Urgent challenges to be taken are that we must strictly analyze the interventions between 'the clear and present danger' of our world and the nuclear herms, and must take appropriate actions toward them without influences from previous international situations that might be subsisted in current international treaties and agreements. This paper identified the features of nuclear threats based on the four categories and examined the possibilities of nuclear terrorism from previous facts with the inductive inference. The results identified the possibility of nuclear facility attack and of radioactive materials theft by the Polico-Religious Groups and others are stood out. The authors would suggest the important of urgent recognition to establish the certain security system against nuclear terrorism. (author)

  7. MI Gap Clearing Kicker Magnet Design Review

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, Chris; /Fermilab

    2008-10-01

    The kicker system requirements were originally conceived for the NOvA project. NOvA is a neutrino experiment located in Minnesota. To achieve the desired neutrino flux several upgrades are required to the accelerator complex. The Recycler will be used as a proton pre-injector for the Main Injector (MI). As the Recycler is the same size as the MI, it is possible to do a single turn fill ({approx}11 {micro}sec), minimizing the proton injection time in the MI cycle and maximizing the protons on target. The Recycler can then be filled with beam while the MI is ramping to extract beam to the target. To do this requires two new transfer lines. The existing Recycler injection line was designed for 10{pi} pbar beams, not the 20{pi} proton beams we anticipate from the Booster. The existing Recycler extraction line allows for proton injection through the MI, while we want direct injection from the Booster. These two lines will be decommissioned. The new injection line from the MI8 line into the Recycler will start at 848 and end with injection kickers at RR104. The new extraction line in the RR30 straight section will start with a new extraction kicker at RR232 and end with new MI injection kickers at MI308. Finally, to reduce beam loss activation in the enclosure, a new gap clearing kicker will be used to extract uncaptured beam created during the slip stack injection process down the existing dump line. It was suggested that the MI could benefit from this type of system immediately. This led to the early installation of the gap clearing system in the MI, followed by moving the system to Recycler during NOvA. The specifications also changed during this process. Initially the rise and fall time requirements were 38 ns and the field stability was {+-}1%. The 38 ns is based on having a gap of 2 RF buckets between injections. (There are 84 RF buckets that can be filled from the Booster for each injection, but 82 would be filled with beam. MI and Recycler contain 588 RF buckets

  8. USGS analysis of the Australian UNCLOS submission

    Science.gov (United States)

    Hutchinson, Deborah R.; Rowland, Robert W.

    2006-01-01

    In November 2004, the Government of Australia made a submission to the Commission on the Limits of the Continental Shelf (CLCS) for 10 extended continental shelf (ECS) regions, utilizing Article-76 of the United Nations Convention on the Law of the Sea (UNCLOS). With information provided in the Australian Executive Summary, the USGS examined the 10 regions of the submission from geological, morphological, and resource perspectives. By their own request, the Australians asked that CLCS take no action on the Australian-Antarctic Territory. The major limitation in this analysis is that no bathymetric soundings or detailed hydrographic profiles were provided in the Australian Executive Summary that might show why the Foot of the Slope (FOS) was chosen or where the 2,500-m contour is located. This represents a major limitation because more than half of the 4,205 boundary points utilize the bathymetric formula line and more than one-third of them utilize the bathymetric constraint line. CLCS decisions on the components of this submission may set a precedent for how ECSs are treated in future submissions. Some of the key decisions will cover (a) how a 'natural prolongation' of a continental margin is determined, particularly if a bathymetric saddle that appears to determine the prolongation is in deep water and is well outside of the 200-nm limit (Exmouth Plateau), (b) defining to what extent that plateaus, rises, caps, banks and spurs that are formed of oceanic crust and from oceanic processes can be considered to be 'natural prolongations' (Kerguelen Plateau), (c) to what degree UNCLOS recognizes reefs and uninhabited micro-islands (specifically, rocks and/or sand shoals) as islands that can have an EEZ (Middleton and Elizabeth Reefs north of Lord Howe Island), and (d) how the Foot of the Slope (FOS) is chosen (Great Australian Bight). The submission contains situations that are relevant to potential future U.S. submissions and are potentially analogous to certain

  9. Clear Channel Assessment in Integrated Medical Environments

    Directory of Open Access Journals (Sweden)

    Bin Zhen

    2008-03-01

    Full Text Available Complementary WLAN and WPAN technologies as well as other wireless technologies will play a fundamental role in the medical environments to support ubiquitous healthcare delivery. This paper investigates clear channel assessment (CCA and its impact on the coexistence of WLAN (IEEE 802.11 high rate direct sequence spread spectrum (HR/DSSS PHY and WPAN (IEEE 802.15.4b in the 2.4 GHz industrial, scientific, and medical (ISM band. We derived closed-form expressions of both energy-based CCA and feature-based CCA. We qualified unequal sensing abilities between them and termed this inequality asymmetric CCA, which is different from the traditional “hidden node” or “exposed node” issues in the homogeneous network. The energy-based CCA was considered in the considered integrated medical environment because the 2.4 GHz ISM band is too crowded to apply feature-based CCA. The WPAN is oversensitive to the 802.11 HR/DSSS signals and the WLAN is insensitive to the 802.15.4b signals. Choosing an optimal CCA threshold requires some prior knowledge of the underlying signals. In the integrated medical environment we considered here, energy-based CCA can effectively avoid possible packet collisions when they are close within the “heterogeneous exclusive CCA range” (HECR. However, when they are separated beyond the HECR, WPAN can still sense the 802.11 HR/DSSS signals, but WLAN loses its sense to the 802.15.4b signals. The asymmetric CCA leads to WPAN traffic in a position secondary to WLAN traffic.

  10. Clear Channel Assessment in Integrated Medical Environments

    Directory of Open Access Journals (Sweden)

    Hara Shinsuke

    2008-01-01

    Full Text Available Abstract Complementary WLAN and WPAN technologies as well as other wireless technologies will play a fundamental role in the medical environments to support ubiquitous healthcare delivery. This paper investigates clear channel assessment (CCA and its impact on the coexistence of WLAN (IEEE 802.11 high rate direct sequence spread spectrum (HR/DSSS PHY and WPAN (IEEE 802.15.4b in the 2.4 GHz industrial, scientific, and medical (ISM band. We derived closed-form expressions of both energy-based CCA and feature-based CCA. We qualified unequal sensing abilities between them and termed this inequality asymmetric CCA, which is different from the traditional "hidden node" or "exposed node" issues in the homogeneous network. The energy-based CCA was considered in the considered integrated medical environment because the 2.4 GHz ISM band is too crowded to apply feature-based CCA. The WPAN is oversensitive to the 802.11 HR/DSSS signals and the WLAN is insensitive to the 802.15.4b signals. Choosing an optimal CCA threshold requires some prior knowledge of the underlying signals. In the integrated medical environment we considered here, energy-based CCA can effectively avoid possible packet collisions when they are close within the "heterogeneous exclusive CCA range" (HECR. However, when they are separated beyond the HECR, WPAN can still sense the 802.11 HR/DSSS signals, but WLAN loses its sense to the 802.15.4b signals. The asymmetric CCA leads to WPAN traffic in a position secondary to WLAN traffic.

  11. When a Cleared Rape Is Not Cleared: A Multilevel Study of Arrest and Exceptional Clearance.

    Science.gov (United States)

    Walfield, Scott M

    2016-05-01

    As rape remains one of the most underreported and least likely to be cleared of the violent crimes, it is of paramount importance to understand the factors associated with the likelihood of a case being cleared by law enforcement. This study uses data from the National Incident-Based Reporting System (NIBRS) and the Law Enforcement Management and Administrative Statistics (LEMAS), and a multilevel modeling approach to examine the relationship between victim, offender, incident, and police department characteristics contrasting the two types of clearance: arrest and exceptional clearance. The latter occurs due to reasons outside of law enforcement's control and despite being considered cleared, the offender is not arrested, charged, nor turned over for prosecution. Of the 16,231 cleared rapes in 238 departments, nearly half (47%) results in exceptional clearance when the victim refuses to cooperate or when prosecution is declined. Incident-level variables have a greater effect on the likelihood of exceptional clearance than victim and offender variables. The department explained a nontrivial amount of variation in the dependent variable, as 37% of the variance in type of clearance was between-department variation. Implications for future research on exceptional clearance and NIBRS are discussed. PMID:25646164

  12. Clear cell renal cell tumors: Not all that is "clear" is cancer.

    Science.gov (United States)

    Williamson, Sean R; Cheng, Liang

    2016-07-01

    Continued improvement of our understanding of the clinical, histologic, and genetic features of renal cell tumors has progressively evolved renal tumor classification, revealing an expanding array of distinct tumor types with different implications for prognosis, patient counseling, and treatment. Although clear cell renal cell carcinoma is unequivocally the most common adult renal tumor, there is growing evidence that some "clear cell" renal neoplasms, such as exemplified by multilocular cystic clear cell renal neoplasm of low malignant potential (formerly multilocular cystic renal cell carcinoma), do not have the same potential for insidious progression and metastasis, warranting reclassification as low malignant potential tumors or benign neoplasms. Still other novel tumor types such as clear cell papillary renal cell carcinoma have been more recently recognized, which similarly have shown a conspicuous absence of aggressive behavior to date, suggesting that these too may be recategorized as noncancerous or may be premalignant neoplasms. This importance for prognosis is increasingly significant in the modern era, in which renal masses are increasingly found incidentally by imaging techniques at a small tumor size, raising consideration for less aggressive management options guided by renal mass biopsy diagnosis, including imaging surveillance, tumor ablation, or partial nephrectomy. PMID:26988177

  13. 76 FR 45730 - Customer Clearing Documentation and Timing of Acceptance for Clearing

    Science.gov (United States)

    2011-08-01

    ... derivatives clearing organization (DCO) level.\\4\\ \\4\\ See, e.g., 76 FR 3698 (Jan. 20, 2011) (Risk Management.... 39.12(b)(2) to implement this provision.\\7\\ \\7\\ 76 FR 3698 (Jan. 20, 2011) (Risk Management... important risk mitigant. The Commission recently proposed Sec. 39.12(b)(7) regarding time frames...

  14. MODIS Collection 6 Clear Sky Restoral (CSR): Filtering Cloud Mast 'Not Clear' Pixels

    Science.gov (United States)

    Meyer, Kerry G.; Platnick, Steven Edward; Wind, Galina; Riedi, Jerome

    2014-01-01

    Correctly identifying cloudy pixels appropriate for the MOD06 cloud optical and microphysical property retrievals is accomplished in large part using results from the MOD35 1km cloud mask tests (note there are also two 250m subpixel cloud mask tests that can convert the 1km cloudy designations to clear sky). However, because MOD35 is by design clear sky conservative (i.e., it identifies "not clear" pixels), certain situations exist in which pixels identified by MOD35 as "cloudy" are nevertheless likely to be poor retrieval candidates. For instance, near the edge of clouds or within broken cloud fields, a given 1km MODIS field of view (FOV) may in fact only be partially cloudy. This can be problematic for the MOD06 retrievals because in these cases the assumptions of a completely overcast homogenous cloudy FOV and 1-dimensional plane-parallel radiative transfer no longer hold, and subsequent retrievals will be of low confidence. Furthermore, some pixels may be identified by MOD35 as "cloudy" for reasons other than the presence of clouds, such as scenes with thick smoke or lofted dust, and should therefore not be retrieved as clouds. With such situations in mind, a Clear Sky Restoral (CSR) algorithm was introduced in C5 that attempts to identify pixels expected to be poor retrieval candidates. Table 1 provides SDS locations for CSR and partly cloudy (PCL) pixels.

  15. Apixaban and atrial fibrillation: no clear advantage.

    Science.gov (United States)

    2014-02-01

    For the prevention of thromboembolic events in patients with atrial fibrillation and a high thrombotic risk, the standard treatment is warfarin, an anticoagulant. Dabigatran, a thrombin inhibitor, is the alternative when warfarin fails to maintain the INR within the therapeutic range. Patients with a moderate thrombotic risk may receive either warfarin or low-dose aspirin. Apixaban, a factor Xa inhibitor anticoagulant, has been authorised in the European Union for use in patients with non-valvular atrial fibrillation and a moderate or high risk of thrombosis. In a double-blind, randomised non-inferiority trial versus warfarin in 18 201 patients, the incidence of stroke or systemic embolism was lower in the apixaban group (average 1.3 versus 1.6 events per 100 patient-years; p = 0.01). This difference was mainly due to a lower incidence of haemorrhagic stroke and did not result in a clear decline in mortality. In addition, these results are undermined by multiple methodological flaws. Clinical evaluation included no trials comparing apixaban with dabigatran; any indirect comparison would be risky given the poor quality of the clinical assessment of both drugs in atrial fibrillation. A double-blind, randomised trial including 5598 patients compared apixaban with aspirin but provided little information on these options in patients with a moderate risk of thrombosis, as most patients were at high risk. In clinical trials, major bleeding events were less frequent with apixaban than with warfarin (average 2.1 versus 3.1 events per 100 patient-years), but they were more frequent with apixaban than with aspirin (1.4 versus 0.9 events per 100 patient-years). In 2013, there is no way of monitoring the anticoagulant activity of apixaban in routine clinical practice, and there is no antidote in case of overdose; the same is true for dabigatran. Apixaban is a substrate for various cytochrome P450 isoenzymes and for P-glycoprotein, creating a risk of multiple drug

  16. 7 CFR 28.178 - Submission of cotton samples.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Submission of cotton samples. 28.178 Section 28.178... REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Classification for Foreign Growth Cotton § 28.178 Submission of cotton samples. Samples of cotton submitted to a Classing Office for classification...

  17. 7 CFR 400.706 - Review of submission.

    Science.gov (United States)

    2010-01-01

    ... and Rates of Premium § 400.706 Review of submission. (a) Prior to providing the submission to the... limited in the length of time or the number of delays. However, delays may make implementation of the... RMA are not sufficient to support the review and implementation of the product; (2) The premium...

  18. 78 FR 38010 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2013-06-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Submission for OMB Review; Comment Request The Department of Commerce will submit to the Office of Management... fishery management organizations. Revision: Submission of trip tickets is now all electronic, resulting...

  19. 75 FR 57284 - Agency Information Collection Activities: Cost Submission

    Science.gov (United States)

    2010-09-20

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Cost Submission... other Federal agencies to comment on an information collection requirement concerning: Cost Submission... forms of information technology; and (e) the annual costs burden to respondents or record keepers...

  20. 75 FR 76022 - Agency Information Collection Activities: Cost Submission

    Science.gov (United States)

    2010-12-07

    ... published in the Federal Register (75 FR 57284) on September 20, 2010, allowing for a 60-day comment period... SECURITY Customs and Border Protection Agency Information Collection Activities: Cost Submission AGENCY: U... approval in accordance with the Paperwork Reduction Act: Cost Submission (CBP Form 247). This is a...

  1. 49 CFR 37.135 - Submission of paratransit plan.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Submission of paratransit plan. 37.135 Section 37... WITH DISABILITIES (ADA) Paratransit as a Complement to Fixed Route Service § 37.135 Submission of paratransit plan. (a) General. Each public entity operating fixed route transportation service, which...

  2. 76 FR 4873 - Notice of Submission for OMB Review

    Science.gov (United States)

    2011-01-27

    ... Review: New. Title of Collection: Striving Readers Comprehensive Literacy Discretionary Grants. OMB... Notice of Submission for OMB Review AGENCY: Department of Education. ACTION: Comment request. SUMMARY..., Office of Management invites comments on the submission for OMB review as required by the...

  3. 75 FR 30006 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2010-05-28

    ... Education Type of Review: New. Title: Striving Readers Comprehensive Literacy State Formula Grant... Submission for OMB Review; Comment Request AGENCY: Department of Education. SUMMARY: The Acting Director... invites comments on the submission for OMB review as required by the Paperwork Reduction Act of...

  4. 19 CFR 177.2 - Submission of ruling requests.

    Science.gov (United States)

    2010-04-01

    ... citations affecting § 177.2, see the List of CFR Sections Affected, which appears in the Finding Aids... 19 Customs Duties 2 2010-04-01 2010-04-01 false Submission of ruling requests. 177.2 Section 177.2... TREASURY (CONTINUED) ADMINISTRATIVE RULINGS General Ruling Procedure § 177.2 Submission of ruling...

  5. 76 FR 15938 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2011-03-22

    ... system (VMS) trip declarations for all scallop vessels, including powerdown declarations; notification of... trip identification; submission of broken trip adjustment and access area trip exchange forms; VMS...) scallop vessels; submission of VMS pre-landing notification form by IFQ vessels; enrollment into the...

  6. 7 CFR 900.25 - Advance submission of testimony.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Advance submission of testimony. 900.25 Section 900.25... § 900.25 Advance submission of testimony. Any person proposing an amendment to a Federal milk marketing agreement or order under § 900.3 of this part, when participating as a witness, shall make copies of his...

  7. 7 CFR 900.31 - Electronic submission of hearing documents.

    Science.gov (United States)

    2010-01-01

    ... and Marketing Orders § 900.31 Electronic submission of hearing documents. To the extent practicable... 7 Agriculture 8 2010-01-01 2010-01-01 false Electronic submission of hearing documents. 900.31 Section 900.31 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL...

  8. 7 CFR 900.41 - Electronic document submission standards.

    Science.gov (United States)

    2010-01-01

    ... Agreements and Marketing Orders § 900.41 Electronic document submission standards. To the extent practicable... 7 Agriculture 8 2010-01-01 2010-01-01 false Electronic document submission standards. 900.41 Section 900.41 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL...

  9. 22 CFR 51.8 - Submission of currently valid passport.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Submission of currently valid passport. 51.8 Section 51.8 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORTS General § 51.8 Submission of currently valid passport. (a) When applying for a new passport, an applicant must submit...

  10. Selecting the right journal for your submission

    OpenAIRE

    Welch, Stephen J.

    2012-01-01

    Increasing pressure on researchers and academic clinicians to publish high volumes of work in highly visible publication outlets means that authors must have a finely tuned, efficient process for submission. One of the key decisions every author must make is where to submit their paper. This article addresses several important components to making that decision, including (I) topic match; (II) acceptance/rejection rate of the journal; (III) speed of review/publication; (IV) distribution of an...

  11. 76 FR 28994 - Submission for OMB Review; Comment Request; A Generic Submission for Formative Research, Pre...

    Science.gov (United States)

    2011-05-19

    ... to measure the satisfaction of both internal and external stakeholders with this collaboration. This customer satisfaction research helps ensure the relevance, utility, and appropriateness of the many... Submission for Formative Research, Pre-Testing, Stakeholder Measures and Advocate Forms at NCI Summary:...

  12. BABAR Web job submission with Globus Authentication and AFS Access

    International Nuclear Information System (INIS)

    We present two versions of a grid job submission system produced for the BaBar experiment. Both use globus job submission to process data spread across various sites, producing output which can be combined for analysis. The problems encountered with authorization and authentication, data location, job submission, and the input and output sandboxes are described, as are the solutions. The total system is still some way short of the aims of enterprises such as the EDG, but represent a significant step along the way

  13. Water Resources Research supports water economics submissions

    Science.gov (United States)

    Griffin, Ronald C.

    2012-09-01

    AGU's international interdisciplinary journal Water Resources Research (WRR) publishes original contributions in hydrology; the physical, chemical, and biological sciences; and the social and policy sciences, including economics, systems analysis, sociology, and law. With the rising relevance of water economics and related social sciences, the editors of WRR continue to encourage submissions on economics and policy. WRR was originally founded in the mid 1960s by Walter Langbein and economist Allen Kneese. Several former WRR editors have been economists—including David Brookshire, Ron Cummings, and Chuck Howe—and many landmark articles in water economics have been published in WRR.

  14. Longbow: A Lightweight Remote Job Submission Tool

    Directory of Open Access Journals (Sweden)

    James Gebbie-Rayet

    2016-01-01

    Full Text Available We present Longbow, a lightweight console-based remote job submission tool and library. Longbow allows the user to quickly and simply run jobs on high performance computing facilities without leaving their familiar desktop environment. Not only does Longbow greatly simplify the management of compute- intensive jobs for experienced researchers, it also lowers the technical barriers surrounding high perfor-mance computation for the next generation of scientists and engineers. Longbow has already been used to remotely submit jobs in a number of projects and has the potential to redefine the manner in which high performance computers are used.

  15. One Clear Image? Challenging Simplicity in Place Branding

    DEFF Research Database (Denmark)

    Ren, Carina Bregnholm; Blichfeldt, Bodil Stilling

    2011-01-01

    Unique selling points! Simplicity sells! One clear identity! One clear image! These are some of the place branding mantras of today. In this paper, this “simplicity trend” is critically examined and challenged by raising the question whether clear images and simplicity are truly the only options...

  16. Analysis of marine stratocumulus clearing events during FIRE

    Science.gov (United States)

    Kloesel, Kevin A.

    1990-01-01

    During FIRE, three major stratocumulus clearing events took place over the project region. These clearing events are analyzed using synoptic variables to determine if these clearing events can be predicted by current modeling techniques. A preliminary statistical evaluation of the correlation between satellite cloud brightness parameters and NMC global model parameters is available in Wylie, et al., 1989.

  17. 77 FR 33468 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2012-06-06

    ... HUMAN SERVICES Administration for Children and Families Submission for OMB Review; Comment Request Proposed Projects: Title: Performance Measures for Community-Centered Healthy Marriage, Pathways to... collection process. Respondents: Office of Family Assistance Funded Community-Centered Healthy...

  18. 75 FR 35440 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2010-06-22

    .... Type of Request: Regular submission. Number of Respondents: 375. Average Hours Per Response... interested educators: basic personal information, teaching experience and ideas for applying program... sea. These materials are then made available to other educators so they may benefit from...

  19. 76 FR 77504 - Notice of Submission for OMB Review

    Science.gov (United States)

    2011-12-13

    ... and Records Management Services, Office of Management. Office of Innovation and Improvement Type of...: The Director, Information Collection Clearance Division, Privacy, Information and Records Management Services, Office of Management, invites comments on the submission for OMB review as required by...

  20. [SDC submission to the Welsh Assembly] [f]ood consultation

    OpenAIRE

    Sustainable Development Commission Wales

    2010-01-01

    The final report of the consultation is entitled 'Food for Wales, food from Wales'. English language version of 'Ymgynghoriad ar fwyd'. Sustainable Development Commission Wales submission to the consultation on a food strategy for Wales. Publisher PDF

  1. 75 FR 30106 - Terrorism Risk Insurance Program; Litigation Management Submissions

    Science.gov (United States)

    2010-05-28

    ... Terrorism Risk Insurance Program; Litigation Management Submissions AGENCY: Departmental Offices. ACTION..., the Terrorism Risk Insurance Program Office is seeking comments regarding Litigation Management..., preferably an original and two copies) to: Terrorism Risk Insurance Program, Public Comment Record,...

  2. Cognitive Mediation of Aggressive, Assertive, and Submissive Behavior in Children.

    Science.gov (United States)

    Deluty, Robert H.

    1985-01-01

    Examines three critical components of interpersonal cognitive problem solving (alternative-thinking ability, evaluative judgments of response alternatives, and consequential thinking) among 188 elementary school students with differing levels of aggressiveness, assertiveness, and submissiveness. Findings indicate interrelatedness of the cognitive…

  3. 76 FR 14034 - Proposed Collection; Comment Request; A Generic Submission for Formative Research, Pretesting...

    Science.gov (United States)

    2011-03-15

    ... HUMAN SERVICES National Institutes of Health Proposed Collection; Comment Request; A Generic Submission... Management and Budget (OMB) for review and approval. Proposed Collection: Title: A Generic Submission for... pretest strategies, concepts, activities and materials while they are under development....

  4. 75 FR 25269 - Proposed Collection; Comment Request; A Generic Submission for Formative Research, Pretesting...

    Science.gov (United States)

    2010-05-07

    ... HUMAN SERVICES National Institutes of Health Proposed Collection; Comment Request; A Generic Submission... and Budget (OMB) for review and approval. Proposed Collection: Title: A Generic Submission for... strategies, concepts, activities and materials while they are under development. This pre- testing,...

  5. 76 FR 46307 - Proposed collection; Comment Request; A Generic Submission for Theory Development and Validation...

    Science.gov (United States)

    2011-08-02

    ... HUMAN SERVICES National Institutes of Health Proposed collection; Comment Request; A Generic Submission... review and approval. Proposed Collection: Title: A Generic Submission for Theory Development and... cancer prevention and control strategies, allow for a better understanding of theoretical constructs...

  6. 78 FR 4418 - Electronic Submission Process for Requesting Export Certificates From the Center for Devices and...

    Science.gov (United States)

    2013-01-22

    ... HUMAN SERVICES Food and Drug Administration Electronic Submission Process for Requesting Export... Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of an electronic submission process for requesting export certificates for products regulated...

  7. 78 FR 35940 - Content of Premarket Submissions for Management of Cybersecurity in Medical Devices; Draft...

    Science.gov (United States)

    2013-06-14

    ... HUMAN SERVICES Food and Drug Administration Content of Premarket Submissions for Management of... Administration (FDA) is announcing the availability of the draft guidance entitled ``Content of Premarket... draft guidance document entitled ``Content of Premarket Submissions for Management of Cybersecurity...

  8. Toxic Substances Control Act Test Submissions 2.0 (TSCATS 2.0)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Toxic Substances Control Act Test Submissions 2.0 (TSCATS 2.0) tracks the submissions of health and safety data submitted to the EPA either as required or...

  9. 78 FR 14558 - Submission for OMB Review; 30-Day Comment Request: A Generic Submission for Formative Research...

    Science.gov (United States)

    2013-03-06

    ... Generic Submission for Formative Research, Pretesting, and Customer Satisfaction of NCI's Communication..., Pretesting, and Customer Satisfaction of NCI's Communication and Education Resources, 0925-0046, Expiration... customers are satisfied with programs. This customer satisfaction research helps ensure the...

  10. 78 FR 20329 - Submission for OMB review; 30-day Comment Request: A Generic Submission for Formative Research...

    Science.gov (United States)

    2013-04-04

    ... Generic Submission for Formative Research, Pretesting, and Customer Satisfaction of NCI's Communication..., and Customer Satisfaction of NCI's Communication and Education Resources, 0925-0046, Expiration Date 2... customers are satisfied with programs. This customer satisfaction research helps ensure the...

  11. Optimized optical clearing method for imaging central nervous system

    Science.gov (United States)

    Yu, Tingting; Qi, Yisong; Gong, Hui; Luo, Qingming; Zhu, Dan

    2015-03-01

    The development of various optical clearing methods provides a great potential for imaging entire central nervous system by combining with multiple-labelling and microscopic imaging techniques. These methods had made certain clearing contributions with respective weaknesses, including tissue deformation, fluorescence quenching, execution complexity and antibody penetration limitation that makes immunostaining of tissue blocks difficult. The passive clarity technique (PACT) bypasses those problems and clears the samples with simple implementation, excellent transparency with fine fluorescence retention, but the passive tissue clearing method needs too long time. In this study, we not only accelerate the clearing speed of brain blocks but also preserve GFP fluorescence well by screening an optimal clearing temperature. The selection of proper temperature will make PACT more applicable, which evidently broaden the application range of this method.

  12. Production and perception of clear speech in Croatian and English

    Science.gov (United States)

    Smiljanić, Rajka; Bradlow, Ann R.

    2005-09-01

    Previous research has established that naturally produced English clear speech is more intelligible than English conversational speech. The major goal of this paper was to establish the presence of the clear speech effect in production and perception of a language other than English, namely Croatian. A systematic investigation of the conversational-to-clear speech transformations across languages with different phonological properties (e.g., large versus small vowel inventory) can provide a window into the interaction of general auditory-perceptual and phonological, structural factors that contribute to the high intelligibility of clear speech. The results of this study showed that naturally produced clear speech is a distinct, listener-oriented, intelligibility-enhancing mode of speech production in both languages. Furthermore, the acoustic-phonetic features of the conversational-to-clear speech transformation revealed cross-language similarities in clear speech production strategies. In both languages, talkers exhibited a decrease in speaking rate and an increase in pitch range, as well as an expansion of the vowel space. Notably, the findings of this study showed equivalent vowel space expansion in English and Croatian clear speech, despite the difference in vowel inventory size across the two languages, suggesting that the extent of vowel contrast enhancement in hyperarticulated clear speech is independent of vowel inventory size.

  13. 75 FR 22609 - Agency Information Collection Activities; Proposals, Submissions, and Approvals: CIS Ombudsman...

    Science.gov (United States)

    2010-04-29

    ... Problem Submission Worksheet. OMB Number: 1601-0004. Frequency: One Time Response. Affected Public... Case Problem Submission Worksheet, DHS Form 7001 and Virtual Ombudsman System AGENCY: Office of the... through DHS Form 7001, Case Problem Submission Worksheet and Supporting Statement Case Problem...

  14. 78 FR 310 - Draft Revision of Guidance for Industry on Providing Regulatory Submissions in Electronic Format...

    Science.gov (United States)

    2013-01-03

    ... the FD&C Act, FDA is issuing this draft guidance, announcing its determination that submission types... files and advertising and promotional labeling submissions. However, FDA accepts and strongly encourages the submission of master files and advertising and promotional labeling materials electronically,...

  15. 48 CFR 1814.302 - Bid submission. (NASA supplements paragraph (b))

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Bid submission. (NASA supplements paragraph (b)) 1814.302 Section 1814.302 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Submission of Bids 1814.302 Bid submission. (NASA...

  16. 37 CFR 1.417 - Submission of translation of international publication.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Submission of translation of... Provisions General Information § 1.417 Submission of translation of international publication. The submission of an English language translation of the publication of an international application pursuant to...

  17. 76 FR 81510 - Draft Guidance for Industry and Food and Drug Administration Staff; the 510(k) Program...

    Science.gov (United States)

    2011-12-28

    ... Communication, Outreach and Development (HFM-40), Center for Biologics Evaluation and Research (CBER), Food and...) Paradigm Guidance. FDA recognizes and supports efforts for global convergence of regulatory systems, and...

  18. The Clearing : Heidegger’s Lichtung and the big scrub

    Directory of Open Access Journals (Sweden)

    Garbutt, Rob

    2010-01-01

    Full Text Available Clearings make settlement possible. Whether on a small scale using an axe and other hand implements to make way for a dwelling and a garden, or on a large scale with a chain strung between two D9 bulldozers in preparation for a major agribusiness development, the process of clearing creates spaces for installing something new. This paper uses the idea of (the clearing, as practice, process, outcome and metaphor, to examine the installation of the locals in a settler society. Using Lismore on the far-north coast of New South Wales, Australia, as a case example, the particular work of clearing that is discussed here is a practice that enables a form of colonisation and settlement that distances itself from its history of migration. This is a history of settler locals who were 'always here', and a colonial form of clearing clears the land and the mind of troubling pasts and of troubling presences. For the locals within a place, then, clearing manages and simplifies a complex set of social and material relations, histories and identities.Using Anthony Appiah's concept the 'space clearing gesture', the paper concludes with a reflection on the space in which the idea of "the clearing" and this paper appears. Do places, in this instance rural places, provide a type of clearing in which certain ideas might appear that may not appear elsewhere? If situatedness matters then the diversity of places where thinking is done is important for our ecology of thought, and in connection with this, perhaps what 'rural cultural studies' does is clear a particular type of space for thinking.

  19. The Clearing: Heidegger’s Lichtung and The Big Scrub

    Directory of Open Access Journals (Sweden)

    Rob Garbutt

    2010-02-01

    Full Text Available Clearings make settlement possible. Whether on a small scale using an axe and other hand implements to make way for a dwelling and a garden, or on a large scale with a chain strung between two D9 bulldozers in preparation for a major agribusiness development, the process of clearing creates spaces for installing something new. This paper uses the idea of (the clearing, as practice, process, outcome and metaphor, to examine the installation of the locals in a settler society. Using Lismore on the far-north coast of New South Wales, Australia, as a case example, the particular work of clearing that is discussed here is a practice that enables a form of colonisation and settlement that distances itself from its history of migration. This is a history of settler locals who were 'always here', and a colonial form of clearing clears the land and the mind of troubling pasts and of troubling presences. For the locals within a place, then, clearing manages and simplifies a complex set of social and material relations, histories and identities. Using Anthony Appiah's concept the 'space clearing gesture', the paper concludes with a reflection on the space in which the idea of "the clearing" and this paper appears. Do places, in this instance rural places, provide a type of clearing in which certain ideas might appear that may not appear elsewhere? If situatedness matters then the diversity of places where thinking is done is important for our ecology of thought, and in connection with this, perhaps what 'rural cultural studies' does is clear a particular type of space for thinking.

  20. European Strategy Preparatory Group - CALL FOR SUBMISSIONS

    CERN Multimedia

    2012-01-01

    As part of the Update of the European Strategy for Particle Physics, the European Strategy Preparatory Group (ESPG) welcomes submissions on issues related to the strategy from individual physicists, from groups of scientists representing a community (an experiment, a topic of theoretical research, etc.) as well as from Institutions and Organizations (funding agencies, ministries, etc).   These contributions will be discussed at the meetings of the Preparatory Group and during the Open Symposium to be held on 10-12 September 2012 in Cracow, and will be made available to the Strategy Group for drafting the Update of the Strategy. How to submit a contribution? Send your contribution on the scientific issues below using the form under http://indico.cern.ch/event/espg_input (preferably as an attached PDF file): - Accelerator Physics - Astroparticle Physics, Gravitation and Cosmology - Flavour Physics and Symmetries - Physics at High Energy Frontier - Physics of Neutrinos - Strong Interaction Physics...

  1. Fall Meeting abstract submission inspires science poetry

    Science.gov (United States)

    Balcerak, Ernie

    2011-08-01

    When the 4 August deadline for submitting Fall Meeting abstracts passed, AGU had received more than 20,000 abstracts, a record-breaking number. The submission process had an unexpected by-product: It inspired some scientists to write haiku on Twitter. (Haiku is a form of Japanese poetry typically having three lines, the first with five syllables, the second with seven, and the third with five.) The following are examples of the haiku tweets, with the hashtag #AGU11AbstractHaiku. (For those who want to keep updated about the Fall Meeting on Twitter, the hashtag is #AGU11.) For more information about the meeting, including registration and housing, visit http://sites.agu.org/fallmeeting/.

  2. A New Type of distributed Enamel based Clearing Electrode

    CERN Document Server

    Kroyer, T; Caspers, Friedhelm; Hellmond, P; Métral, E; Wendel, J C; Zimmermann, F

    2007-01-01

    Clearing electrodes can be used for electron cloud (EC) suppression in high intensity particle accelerators. In this paper the use of low and highly resistive layers on a dielectric substrate are examined. The beam coupling impedance of such a structure is evaluated. Furthermore the clearing efficiency as well as technological issues are discussed.

  3. 78 FR 72475 - Derivatives Clearing Organizations and International Standards

    Science.gov (United States)

    2013-12-02

    ... organizations) H. Regulation 39.36 (Risk management for systemically important derivatives clearing... of material risk-related rule changes by systemically important derivatives clearing organizations) O... Market Utilities as Systemically Important, 76 FR 44763, 44774 (July 27, 2011) (final rule)....

  4. 78 FR 50259 - Derivatives Clearing Organizations and International Standards

    Science.gov (United States)

    2013-08-16

    ... Clearing Organizations) H. Regulation 39.36 (Risk Management for Systemically Important Derivatives... market participants, strengthen the risk management practices of DCOs, and increase overall confidence in...-554, 114 Stat. 2763 (2000). \\5\\ See A New Regulatory Framework for Clearing Organizations, 66 FR...

  5. ClearPEM: prototype PET device dedicated to breast imaging

    CERN Multimedia

    Joao Varela

    2009-01-01

    Clinical trials have begun in Portugal on a new breast imaging system (ClearPEM) using positron emission tomography (PET). The system, developed by a Portuguese consortium in collaboration with CERN and laboratories participating in the Crystal Clear collaboration, will detect even the smallest tumours and thus help avoid unnecessary biopsies.

  6. 75 FR 77576 - General Regulations and Derivatives Clearing Organizations

    Science.gov (United States)

    2010-12-13

    ... company or organization, or equivalent governing body.'' See 75 FR at 63747. Proposed Sec. 39.10(c)(1)(iii... COMMISSION 17 CFR Parts 1 and 39 RIN 3038-AC98 General Regulations and Derivatives Clearing Organizations... amendments would establish the regulatory standards for compliance with derivatives clearing...

  7. Comparison of skin optical clearing by different drug delivery method

    International Nuclear Information System (INIS)

    Previous studies have shown that optical clearing techniques have great potential for optical diagnosis and therapy. In order to further discuss the effect by different drug delivery method, diffusion chambers were used to simulate in vivo physiological environment; and the optical clearing agents were acted on the surface of porcine skin, the saline was contacted with the dermal side (epidermal application). Then they were compared with the traditional method-samples immersed in the optical clearing agents (mainly dermal immersion). The transmission intensity of skin was monitored by an integrating sphere system. The changes in thickness were measured before and after experiments. The results showed that the optical clearing effect and the changes in thickness are not coincident under the two different methods. It indicates that the optical clearing effect and mechanism may relate to the drug delivery method.

  8. Comparison of skin optical clearing by different drug delivery method

    Energy Technology Data Exchange (ETDEWEB)

    Mao, Z; Ge, X [Department of Fundamental Theories, Shandong Sports University, Jinan, 250102 (China); Li, E, E-mail: mm73@163.com [Institute of Physical Education, Huazhong Normal University, Wuhan, 430079 (China)

    2011-01-01

    Previous studies have shown that optical clearing techniques have great potential for optical diagnosis and therapy. In order to further discuss the effect by different drug delivery method, diffusion chambers were used to simulate in vivo physiological environment; and the optical clearing agents were acted on the surface of porcine skin, the saline was contacted with the dermal side (epidermal application). Then they were compared with the traditional method-samples immersed in the optical clearing agents (mainly dermal immersion). The transmission intensity of skin was monitored by an integrating sphere system. The changes in thickness were measured before and after experiments. The results showed that the optical clearing effect and the changes in thickness are not coincident under the two different methods. It indicates that the optical clearing effect and mechanism may relate to the drug delivery method.

  9. A simple formula for determining globally clear skies

    Energy Technology Data Exchange (ETDEWEB)

    Long, C.N.; George, A.T.; Mace, G.G. [Penn State Univ., University Park, PA (United States)] [and others

    1996-04-01

    Surface measurements to serve as {open_quotes}ground truth{close_quotes} are of primary importance in the development of retrieval algorithms using satellite measurements to predict surface irradiance. The most basic algorithms of this type deal with clear sky (i.e., cloudless) top-to-surface shortwave (SW) transfer, serving as a necessary prerequisite towards treating both clear and cloudy conditions. Recently, atmosphere SW cloud forcing to infer the possibility of excess atmospheric absorption (compared with model results) in cloudy atmospheres. The surface component of this ratio relies on inferring the expected clear sky SW irradiance to determine the effects of clouds on the SW energy budget. Solar renewable energy applications make use of clear and cloud fraction climatologies to assess solar radiation resources. All of the above depend to some extent on the identification of globally clear sky conditions and the attendant measurements of downwelling SW irradiance.

  10. Molecular Characterization of Clear Cell Lesions of Head and Neck.

    Science.gov (United States)

    Jain, Anshi; Shetty, Devi Charan; Juneja, Saurabh; Narwal, Nidhi

    2016-05-01

    The salivary glands, oral mucosa and jaws constitute a group of lesions which are heterogeneous in nature and are odontogenic, salivary or metastatic in origin. This group of tumours is termed as Clear Cell Tumours. Fixation artifacts are one of the most important reasons for the cell to appear clear but clearing of cells may also result from cytoplasmic accumulation of water, presence of glycogen within the cell, intermediate filaments, immature zymogen granules, or a paucity of cellular organelles. Clear cell Odontogenic neoplasms predominantly include odontogenic carcinoma, ameloblastoma and calcifying epithelial odontogenic tumour. Clear cell tumours of salivary gland origin are almost invariably malignant in nature but they do include two benign lesions. Very frequently, surgical pathologist encounters clear cells in many malignant neoplasms, the nature and sources of which are undetermined on the basis of conventional histopathology. This review will selectively discuss the clinicopathological features of neoplasms which at times may pose a diagnostic challenge and dilemma due to clear cell changes. PMID:27437379

  11. Clearing and Labeling Techniques for Large-Scale Biological Tissues.

    Science.gov (United States)

    Seo, Jinyoung; Choe, Minjin; Kim, Sung-Yon

    2016-06-30

    Clearing and labeling techniques for large-scale biological tissues enable simultaneous extraction of molecular and structural information with minimal disassembly of the sample, facilitating the integration of molecular, cellular and systems biology across different scales. Recent years have witnessed an explosive increase in the number of such methods and their applications, reflecting heightened interest in organ-wide clearing and labeling across many fields of biology and medicine. In this review, we provide an overview and comparison of existing clearing and labeling techniques and discuss challenges and opportunities in the investigations of large-scale biological systems. PMID:27239813

  12. Clear-PEM, a dedicated PET camera for mammography

    CERN Document Server

    Lecoq, P

    2002-01-01

    Preliminary results suggest that Positron Emission Mammography (PEM) can offer a noninvasive method for the diagnosis of breast cancer. Metabolic images from PEM contain unique information not available from conventional morphologic imaging techniques and aid in expeditiously establishing the diagnosis of cancer. A dedicated machine seems to offer better perspectives in terms of position resolution and sensitivity. This paper describes the concept of Clear-PEM, the system presently developed by the Crystal Clear Collaboration at CERN for an evaluation of this approach. This device is based on new crystals introduced by the Crystal Clear as well as on modern data acquisition techniques developed for the large experiments in high energy physics experiments.

  13. Molecular Air Data Clear Air Turbulence Sensor: MADCAT Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Clear air turbulence (CAT), often referred to as "air pockets," is attributed to Kelvin-Helmholtz instabilities at altitudes generally above 18,000ft, often in the...

  14. Molecular Air Data Clear Air Turbulence Sensor: MADCAT Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Clear air turbulence (CAT), often referred to as "air pockets," is attributed to Kelvin-Helmholtz instabilities at altitudes usually above 18,000ft, often without...

  15. Reconstruction of Clear-PEM data with STIR

    CERN Document Server

    Martins, M V; Rodrigues, P; Trindade, A; Oliveira, N; Correia, M; Cordeiro, H; Ferreira, N C; Varela, J; Almeida, P

    2006-01-01

    The Clear-PEM scanner is a device based on planar detectors that is currently under development within the Crystal Clear Collaboration, at CERN. The basis for 3D image reconstruction in Clear-PEM is the software for tomographic image reconstruction (STIR). STIR is an open source object-oriented library that efficiently deals with the 3D positron emission tomography data sets. This library was originally designed for the traditional cylindrical scanners. In order to make its use compatible with planar scanner data, new functionalities were introduced into the library's framework. In this work, Monte Carlo simulations of the Clear-PEM scanner acquisitions were used as input for image reconstruction with the 3D OSEM algorithm available in STIR. The results presented indicate that dual plate PEM data can be accurately reconstructed using the enhanced STIR framework.

  16. CBFS: high performance feature selection algorithm based on feature clearness.

    Directory of Open Access Journals (Sweden)

    Minseok Seo

    Full Text Available BACKGROUND: The goal of feature selection is to select useful features and simultaneously exclude garbage features from a given dataset for classification purposes. This is expected to bring reduction of processing time and improvement of classification accuracy. METHODOLOGY: In this study, we devised a new feature selection algorithm (CBFS based on clearness of features. Feature clearness expresses separability among classes in a feature. Highly clear features contribute towards obtaining high classification accuracy. CScore is a measure to score clearness of each feature and is based on clustered samples to centroid of classes in a feature. We also suggest combining CBFS and other algorithms to improve classification accuracy. CONCLUSIONS/SIGNIFICANCE: From the experiment we confirm that CBFS is more excellent than up-to-date feature selection algorithms including FeaLect. CBFS can be applied to microarray gene selection, text categorization, and image classification.

  17. Clearing Barter Exchange Markets: Kidney Exchange and Beyond

    OpenAIRE

    Glorie, Kristiaan

    2014-01-01

    markdownabstract__Abstract__ Advanced computer assisted markets, otherwise known as smart markets, are becoming an important part of our modern society. This dissertation considers smart barter exchange markets, which enable people to trade a wide range of goods: from shifts, to houses, to kidneys. Centralized and computerized clearing is what makes these markets ‘smart’. The market clearing problem is to match demand and supply so as to maximize the gains of trade. Trades, in this regard, ne...

  18. Global horizontal irradiance clear sky models : implementation and analysis.

    Energy Technology Data Exchange (ETDEWEB)

    Stein, Joshua S.; Hansen, Clifford W.; Reno, Matthew J.

    2012-03-01

    Clear sky models estimate the terrestrial solar radiation under a cloudless sky as a function of the solar elevation angle, site altitude, aerosol concentration, water vapor, and various atmospheric conditions. This report provides an overview of a number of global horizontal irradiance (GHI) clear sky models from very simple to complex. Validation of clear-sky models requires comparison of model results to measured irradiance during clear-sky periods. To facilitate validation, we present a new algorithm for automatically identifying clear-sky periods in a time series of GHI measurements. We evaluate the performance of selected clear-sky models using measured data from 30 different sites, totaling about 300 site-years of data. We analyze the variation of these errors across time and location. In terms of error averaged over all locations and times, we found that complex models that correctly account for all the atmospheric parameters are slightly more accurate than other models, but, primarily at low elevations, comparable accuracy can be obtained from some simpler models. However, simpler models often exhibit errors that vary with time of day and season, whereas the errors for complex models vary less over time.

  19. Coastal sediment elevation change following anthropogenic mangrove clearing

    Science.gov (United States)

    Hayden, Heather L.; Granek, Elise F.

    2015-11-01

    Coastal mangrove forests along tropical shorelines serve as an important interface between land and sea. They provide a physical buffer protecting the coastline from erosion and act as sediment "traps" catching terrestrial sediment, thus preventing smothering of subtidal coral reefs. Coastal development that removes mangrove habitat may impact adjacent nearshore coral reefs through sedimentation and nutrient loading. We examined differences in sediment elevation change between patches of open-coast intact and anthropogenically cleared red mangroves (Rhizophora mangle) on the east side of Turneffe Atoll, Belize, to quantify changes following mangrove clearing. Samples were collected over a 24 month period at five study sites, each containing paired intact (+mangrove) and cleared (-mangrove) plots. Five sediment elevation pins were deployed in each plot: behind areas cleared of mangroves (-mangrove) and behind adjacent intact mangroves (+mangrove). Sediment elevation increased at intact mangrove sites (M = +3.83 mm, SE = 0.95) whereas cleared mangrove areas suffered elevation loss (M = -7.30 mm, SE = 3.38). Mangroves inshore of partial or continuous gaps in the adjacent fringing reefs had higher rates of elevation loss (M = -15.05 mm) than mangroves inshore of continuous fringing reefs (M = -1.90 mm). Our findings provide information on potential effects of mangrove clearing and the role of offshore habitat characteristics on coastal sediment trapping and maintenance of sediment elevation by mangroves. With implications for coastline capacity to adjust to sea level rise, these findings are relevant to management of coastal fringing mangrove forests across the Caribbean.

  20. Changes in biotic and abiotic processes following mangrove clearing

    Science.gov (United States)

    Granek, Elise; Ruttenberg, Benjamin I.

    2008-12-01

    Mangrove forests, important tropical coastal habitats, are in decline worldwide primarily due to removal by humans. Changes to mangrove systems can alter ecosystem properties through direct effects on abiotic factors such as temperature, light and nutrient supply or through changes in biotic factors such as primary productivity or species composition. Despite the importance of mangroves as transitional habitats between land and sea, little research has examined changes that occur when they are cleared. We examined changes in a number of biotic and abiotic factors following the anthropogenic removal of red mangroves ( Rhizophora mangle) in the Panamanian Caribbean, including algal biomass, algal diversity, algal grazing rates, light penetration, temperature, sedimentation rates and sediment organic content. In this first study examining multiple ecosystem-level effects of mangrove disturbance, we found that areas cleared of mangroves had higher algal biomass and richness than intact mangrove areas. This increase in algal biomass and richness was likely due to changes in abiotic factors (e.g. light intensity, temperature), but not biotic factors (fish herbivory). Additionally the algal and cyanobacterial genera dominating mangrove-cleared areas were rare in intact mangroves and included a number of genera that compete with coral for space on reefs. Interestingly, sedimentation rates did not differ between intact and cleared areas, but the sediments that accumulated in intact mangroves had higher organic content. These findings are the first to demonstrate that anthropogenic clearing of mangroves changes multiple biotic and abiotic processes in mangrove forests and that some of these changes may influence adjacent habitats such as coral reefs and seagrass beds. Additional research is needed to further explore the community and ecosystem-level effects of mangrove clearing and their influence on adjacent habitats, but it is clear that mangrove conservation is an

  1. Author Guidelines - Standards for Submission Diretrizes para Autores - Normas de Submissão

    Directory of Open Access Journals (Sweden)

    Revista Brasileira de Medicina de Família e Comunidade RBMFC

    2011-09-01

    Full Text Available

    Purpose and Editorial Policy

    The peer review process

    Sections and Types of Articles

    Presentation and Preparation of Manuscripts

    Electronic Submissions

    Statement of authorship

    Sample Statement of Authorship and Responsibility

    Research ethics

    Acknowledgments

    Additional doubts and clarification

    Objetivo e Política Editorial

    Processo de avaliação pelos pares

    Seções e Tipos de Trabalhos

    Apresentação e Preparo dos Manuscritos

    Submissão Eletrônica

    Declaração de Autoria e responsabilidade dos autores

    Exemplo de Declaração de Autoria e Responsabilidade

    Ética em Pesquisa

    Agradecimentos

    Dúvidas e Esclarecimentos adicionais

  2. A Comparison of Parameter Study Creation and Job Submission Tools

    Science.gov (United States)

    DeVivo, Adrian; Yarrow, Maurice; McCann, Karen M.; Biegel, Bryan (Technical Monitor)

    2001-01-01

    We consider the differences between the available general purpose parameter study and job submission tools. These tools necessarily share many features, but frequently with differences in the way they are designed and implemented For this class of features, we will only briefly outline the essential differences. However we will focus on the unique features which distinguish the ILab parameter study and job submission tool from other packages, and which make the ILab tool easier and more suitable for use in our research and engineering environment.

  3. REMINDER : deadline for submission of reimbursements claims to UNIQA

    CERN Multimedia

    HR Department

    2011-01-01

    We would like to remind you of the resolution which took effect from 1 June 2010 changing the deadline for submitting a claim from 24 months to 12 months from the invoice date (as opposed to from the time of treatment). As a transitional measure, it is still possible to submit invoices issued prior to 1 June 2010 as long as they do not date back to more than two years (from the invoice date) at the time of submission. The deadline for transitional claims is 31 May 2011. You are advised to check any outstanding submissions that you have since, as from 1 June 2011, no transitional claims will be accepted.  

  4. Anterior Crossbite and Crowding Correction with a Series of Clear Aligners Involving Lower Incisor Extraction: "The Clear Way" Case Report.

    Science.gov (United States)

    Bawaskar, Naval Suresh

    2015-01-01

    The Clear Aligner can be used to correct tooth movement without involving extraction, surgery, and other adjunct orthopaedic appliances. Some forms ofattachments are required with clear aligners to achieve all major types of orthodontic tooth movements. The Clear Aligner is a procedure that can be performed by a clinician with computer simulation/calculation. Since the Clear Aligner can be fabricated in steps, it is readily available to change the treatment sequence throughout the course of the treatment in cases of complex malocclusions. The patient can receive any necessary dental procedures with ease during the course of the treatment. The treatment can also be easily resumed even if the patient has not worn the aligners for a period of time. The purpose of this article is to report dental anterior crossbite correction with a series of Clear Aligners without the use of any forms of attachments. The Clear Aligner could be used as an alternative in appropriate cases for those who are reluctant with conventional appliances. PMID:27029089

  5. Mines and human casualties: a robotics approach toward mine clearing

    Science.gov (United States)

    Ghaffari, Masoud; Manthena, Dinesh; Ghaffari, Alireza; Hall, Ernest L.

    2004-10-01

    An estimated 100 million landmines which have been planted in more than 60 countries kill or maim thousands of civilians every year. Millions of people live in the vast dangerous areas and are not able to access to basic human services because of landmines" threats. This problem has affected many third world countries and poor nations which are not able to afford high cost solutions. This paper tries to present some experiences with the land mine victims and solutions for the mine clearing. It studies current situation of this crisis as well as state of the art robotics technology for the mine clearing. It also introduces a survey robot which is suitable for the mine clearing applications. The results show that in addition to technical aspects, this problem has many socio-economic issues. The significance of this study is to persuade robotics researchers toward this topic and to peruse the technical and humanitarian facets of this issue.

  6. Diagnosis of clear sky ultraviolet radiation for Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Lemus Deschamps, L. [Bureau of Meteorology Research Centre (Australia); Galindo, I.; Solano, R.; Elizalde, A.T.; Fonseca, J. [Centro Universitario de Investigaciones en Ciencias del Ambiente, University of Colima (Mexico)

    2002-07-01

    A discrete-ordinate radiative transfer model is employed to develop a regional clear sky ultraviolet (UV) diagnosis system. The clear sky UV radiation, weighted by the spectral sensitivity of human skin is calculated using the Total Ozone Mapping Spectrometer (TOMS) data sets. Examples of the geographical clear sky UV Index distributions are presented and the model results are compared with surface UV measurements from University of Colima for 1999. [Spanish] Utilizando un modelo de transferencia de radiacion de ordenadas discretas se desarrolla un sistema para el diagnostico de la distribucion de radiacion ultravioleta para cielo despejado en la Republica Mexicana. La radiacion para cielo despejado se obtiene utilizando la respuesta espectral de la piel humana y los datos de satelite de ozono total registrados por el espectrometro TOMS. Se presentan ejemplos del Indice de radiacion ultravioleta (UV Index) calculados con el modelo y se comparan con las mediciones en superficie obtenidas en la Universidad de Colima durante 1999.

  7. A stochastic framework for clearing of reactive power market

    Energy Technology Data Exchange (ETDEWEB)

    Amjady, N. [Department of Electrical Engineering, Semnan University, Semnan (Iran); Rabiee, A.; Shayanfar, H.A. [Center of excellence for Power System Automation and Operation, Department of Electrical Engineering, Iran University of Science and Technology, Tehran (Iran)

    2010-01-15

    This paper presents a new stochastic framework for clearing of day-ahead reactive power market. The uncertainty of generating units in the form of system contingencies are considered in the reactive power market-clearing procedure by the stochastic model in two steps. The Monte-Carlo Simulation (MCS) is first used to generate random scenarios. Then, in the second step, the stochastic market-clearing procedure is implemented as a series of deterministic optimization problems (scenarios) including non-contingent scenario and different post-contingency states. In each of these deterministic optimization problems, the objective function is total payment function (TPF) of generators which refers to the payment paid to the generators for their reactive power compensation. The effectiveness of the proposed model is examined based on the IEEE 24-bus Reliability Test System (IEEE 24-bus RTS). (author)

  8. Multiobjective clearing of reactive power market in deregulated power systems

    Energy Technology Data Exchange (ETDEWEB)

    Rabiee, A.; Shayanfar, H. [Center of Excellence for Power System Automation and Operation, Electrical Engineering Department, Iran University of Science and Technology (IUST), Narmak, Tehran 16846 (Iran); Amjady, N. [Department of Electrical Engineering, Semnan University, Semnan (Iran)

    2009-09-15

    This paper presents a day-ahead reactive power market which is cleared in the form of multiobjective context. Total payment function (TPF) of generators, representing the payment paid to the generators for their reactive power compensation, is considered as the main objective function of reactive power market. Besides that, voltage security margin, overload index, and also voltage drop index are the other objective functions of the optimal power flow (OPF) problem to clear the reactive power market. A Multiobjective Mathematical Programming (MMP) formulation is implemented to solve the problem of reactive power market clearing using a fuzzy approach to choose the best compromise solution according to the specific preference among various non-dominated (pareto optimal) solutions. The effectiveness of the proposed method is examined based on the IEEE 24-bus reliability test system (IEEE 24-bus RTS). (author)

  9. Combined Papillated Bowen Disease and Clear Cell Atypical Fibroxanthoma

    Directory of Open Access Journals (Sweden)

    Dimas Suárez-Vilela

    2010-05-01

    Full Text Available We describe a case of papillated Bowen disease (PBD, associated with a clear cell atypical fibroxanthoma (CCAFXA. The epidermal lesion showed a bowenoid papillomatous growth pattern with histologic features suggestive of infection by human papilloma virus (HPV. In the dermis a neoplasm made up by spindled or polygonal cells with wide clear cytoplasm and moderate nuclear pleomorphism was found. Immunohistochemical characteristics of these two lesions were clearly different. The atypical cells of the intraepidermal proliferation were positive for AE1-AE3 anticytokeratin antibody, EMA, p16, p53 and p63. The dermal tumor was positive for vimentin, CD10, CD68, CD99, alpha-1-antitrypsin and c-kit. Histological features and immunohistochemical profile of the dermal tumor corresponded to a CCAFXA, a very uncommon neoplasm of which only 10 cases have been reported. In situ hybridization for numerous types of HPVs was negative in both lesions.

  10. Advanced ThioClear process testing. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Lani, B.

    1998-03-01

    Wet scrubbing is the leading proven commercial post-combustion FGD technology available to meet the sulfur dioxide reductions required by the Clean Air Act Amendments. To reduce costs associated with wet FGD, Dravo Lime Company has developed the ThioClear process. ThioClear is an ex-situ forced oxidation magnesium-enhanced lime FGD process. ThioClear process differs from the conventional magnesium-enhanced lime process in that the recycle liquor has minimal suspended solids and the by-products are wallboard quality gypsum and magnesium hydroxide, an excellent reagent for water treatment. The process has demonstrated sulfur dioxide removal efficiencies of +95% in both a vertical spray scrubber tower and a horizontal absorber operating at gas velocities of 16 fps, respectively. This report details the optimization studies and associated economics from testing conducted at Dravo Lime Company`s pilot plant located at the Miami Fort Station of the Cincinnati Gas and Electric Company.

  11. A stochastic framework for clearing of reactive power market

    International Nuclear Information System (INIS)

    This paper presents a new stochastic framework for clearing of day-ahead reactive power market. The uncertainty of generating units in the form of system contingencies are considered in the reactive power market-clearing procedure by the stochastic model in two steps. The Monte-Carlo Simulation (MCS) is first used to generate random scenarios. Then, in the second step, the stochastic market-clearing procedure is implemented as a series of deterministic optimization problems (scenarios) including non-contingent scenario and different post-contingency states. In each of these deterministic optimization problems, the objective function is total payment function (TPF) of generators which refers to the payment paid to the generators for their reactive power compensation. The effectiveness of the proposed model is examined based on the IEEE 24-bus Reliability Test System (IEEE 24-bus RTS). (author)

  12. Multiobjective clearing of reactive power market in deregulated power systems

    International Nuclear Information System (INIS)

    This paper presents a day-ahead reactive power market which is cleared in the form of multiobjective context. Total payment function (TPF) of generators, representing the payment paid to the generators for their reactive power compensation, is considered as the main objective function of reactive power market. Besides that, voltage security margin, overload index, and also voltage drop index are the other objective functions of the optimal power flow (OPF) problem to clear the reactive power market. A Multiobjective Mathematical Programming (MMP) formulation is implemented to solve the problem of reactive power market clearing using a fuzzy approach to choose the best compromise solution according to the specific preference among various non-dominated (pareto optimal) solutions. The effectiveness of the proposed method is examined based on the IEEE 24-bus reliability test system (IEEE 24-bus RTS). (author)

  13. Clear cell colitis: A form of microscopic colitis in children

    Institute of Scientific and Technical Information of China (English)

    Jan J(o)zefczuk; Bogdan Marian Wozniewicz

    2008-01-01

    AIM: To describe a new clinical and pathological subtype of microscopic colitis in children.METHODS: A selected group of children with abdominal pain, constipation and/or diarrhoea showing discrete or no macroscopic abnormalities on endoscopy was described.RESULTS: Multiple biopsies of colon showed large mononuclear clear cells in lamina propria of mucous membrane provided that good quality histological sections were performed and observed under a higher magnification. Otherwise, they could be misinterpreted as artefacts. Their presence in routine histology might suggest a systemic storage disease (Whipple's disease), and neuronal intestine dysplasia.Using immunohistochemical staining and electron microscopy we confirmed their origin from CD68 positive mononuclear macrophages.CONCLUSION: The presence of large clear cells is a constant microscopic feature. Failure of transient large bowel stationary macrophages plays a role in the pathogenesis of this benign microscopic clear cell colitis,sometimes coexisting with allergy.

  14. A new versatile clearing method for brain imaging

    Science.gov (United States)

    Costantini, Irene; Di Giovanna, Antonino Paolo; Allegra Mascaro, Anna Letizia; Silvestri, Ludovico; Müllenbroich, Marie Caroline; Sacconi, Leonardo; Pavone, Francesco S.

    2015-03-01

    Light scattering inside biological tissue is a limitation for large volumes imaging with microscopic resolution. Based on refractive index matching, different approaches have been developed to reduce scattering in fixed tissue. High refractive index organic solvents and water-based optical clearing agents, such as Sca/e, SeeDB and CUBIC have been used for optical clearing of entire mouse brain. Although these methods guarantee high transparency and preservation of the fluorescence, though present other non-negligible limitations. Tissue transformation by CLARITY allows high transparency, whole brain immunolabelling and structural and molecular preservation. This method however requires a highly expensive refractive index matching solution limiting practical applicability to large volumes. In this work we investigate the effectiveness of a water-soluble clearing agent, the 2,2'-thiodiethanol (TDE) to clear mouse and human brain. TDE does not quench the fluorescence signal, is compatible with immunostaining and does not introduce any deformation at sub-cellular level. The not viscous nature of the TDE make it a suitable agent to perform brain slicing during serial two-photon (STP) tomography. In fact, by improving penetration depth it reduces tissue slicing, decreasing the acquisition time and cutting artefacts. TDE can also be used as a refractive index medium for CLARITY. The potential of this method has been explored by imaging blocks of dysplastic human brain transformed with CLARITY, immunostained and cleared with the TDE. This clearing approach significantly expands the application of single and two-photon imaging, providing a new useful method for quantitative morphological analysis of structure in mouse and human brain.

  15. A versatile new technique to clear mouse and human brain

    Science.gov (United States)

    Costantini, Irene; Di Giovanna, Antonino Paolo; Allegra Mascaro, Anna Letizia; Silvestri, Ludovico; Müllenbroich, Marie Caroline; Sacconi, Leonardo; Pavone, Francesco S.

    2015-07-01

    Large volumes imaging with microscopic resolution is limited by light scattering. In the last few years based on refractive index matching, different clearing approaches have been developed. Organic solvents and water-based optical clearing agents have been used for optical clearing of entire mouse brain. Although these methods guarantee high transparency and preservation of the fluorescence, though present other non-negligible limitations. Tissue transformation by CLARITY allows high transparency, whole brain immunolabelling and structural and molecular preservation. This method however requires a highly expensive refractive index matching solution limiting practical applicability. In this work we investigate the effectiveness of a water-soluble clearing agent, the 2,2'-thiodiethanol (TDE) to clear mouse and human brain. TDE does not quench the fluorescence signal, is compatible with immunostaining and does not introduce any deformation at sub-cellular level. The not viscous nature of the TDE make it a suitable agent to perform brain slicing during serial two-photon (STP) tomography. In fact, by improving penetration depth it reduces tissue slicing, decreasing the acquisition time and cutting artefacts. TDE can also be used as a refractive index medium for CLARITY. The potential of this method has been explored by imaging a whole transgenic mouse brain with the light sheet microscope. Moreover we apply this technique also on blocks of dysplastic human brain tissue transformed with CLARITY and labeled with different antibody. This clearing approach significantly expands the application of single and two-photon imaging, providing a new useful method for quantitative morphological analysis of structure in mouse and human brain.

  16. Cladoceran zooplankton abundance under clear and snow-covered ice

    Science.gov (United States)

    DeBates, T.J.; Chipps, S.R.; Ward, M.C.; Werlin, K.B.; Lorenzen, P.B.

    2003-01-01

    We described the distribution of cladoceran zooplankton under the ice in a natural, glacial lake. Local light availability apparently altered the spatial distribution of cladocerans. Light levels measured under snow-covered areas (0.178 lux) were an order of magnitude less than those measured at the same depth under clear ice (1.750 lux). Cladoceran density under snow-covered areas was significantly higher (Bosmina spp.=3.34/L; Daphnia spp.=0.61/L) than cladoceran abundance under clear ice (Bosmina spp.=0.91/L; Daphnia spp.=0.19/L).

  17. Glycogen-rich clear cell carcinoma of the breast

    DEFF Research Database (Denmark)

    Sørensen, Flemming Brandt; Paulsen, S M

    1987-01-01

    cells were stained by antisera to carcinoembryonic antigen, keratin and epithelial membrane antigen, but not by antisera to alpha-lactalbumin, desmin or vimentin. Ultrastructurally, the epithelial derivation of the tumour was confirmed. Only a few intracytoplasmic lumina were demonstrated. The tumour......The light microscopic, immunohistochemical and ultrastructural features of a clear cell carcinoma of the breast have been studied. Both intraductal and invasive components were found. Histochemistry showed large amounts of intracytoplasmic glycogen and sparse neutral mucin in the tumour. The tumour...... was classified as a mucin-containing variant of glycogen-rich, clear cell carcinoma of the breast....

  18. Does gently clearing the nasal passage affect odor identification?

    Directory of Open Access Journals (Sweden)

    Mitchell G. Spring

    2014-12-01

    Full Text Available Identifying scents in a wine’s bouquet is considered one of the most important steps in the process of wine tasting. An individual’s ability to successfully do this is dependent on the sense of smell; thus, altering the nasal microenvironment could have a powerful effect on the wine tasting experience. In the present study, we examined olfactory performance in healthy participants who cleared their nasal cavity before odorant presentations. Fifty undergraduate participants were assessed with a standardized test of olfaction requiring the recognition of a battery of odors. Half of these participants cleared mucus from their nasal cavities (by gently blowing their noses prior to the assessment. No difference was found in performance between those who cleared their nasal passages and those who did not. Further, data were not different than known population data from the test. These data suggest that gently clearing the nasal cavity before presentation of odorants bears no effect on the ability to perceive those odor qualities.

  19. 76 FR 16587 - Risk Management Requirements for Derivatives Clearing Organizations

    Science.gov (United States)

    2011-03-24

    ... COMMISSION 17 CFR Part 39 RIN 3038-AC98 Risk Management Requirements for Derivatives Clearing Organizations... Principle D (Risk Management) and would establish a related reporting requirement under Core Principle J... Exchange Act (CEA) \\4\\ to establish a comprehensive regulatory framework to reduce risk,...

  20. 76 FR 3697 - Risk Management Requirements for Derivatives Clearing Organizations

    Science.gov (United States)

    2011-01-20

    ... Trading Commission 17 CFR Part 39 Risk Management Requirements for Derivatives Clearing Organizations...; ] COMMODITY FUTURES TRADING COMMISSION 17 CFR Part 39 RIN 3038-AC98 Risk Management Requirements for...) Monitoring, reporting, and enforcement (b) Product eligibility 2. Risk management (a) General (b)...

  1. Marketing Strategies of United Kingdom Universities during Clearing and Adjustment

    Science.gov (United States)

    Mogaji, Emmanuel

    2016-01-01

    Purpose: The clearing system in the UK enables students without a university place after exam results have been announced to find suitable vacancies, as it is important for universities to fill their vacancies as any shortfall loses them a lot of money. The purpose of this paper is to examine marketing strategies adopted by UK universities on…

  2. Clear cell adenocarcinoma of the bladder with intravesical cervical invasion.

    Science.gov (United States)

    Marchalik, Daniel; Krishnan, Jayashree; Verghese, Mohan; Venkatesan, Krishnan

    2015-01-01

    A 26-year-old woman with a complicated urological and gynecological history with uterine didelphys with bilaterally inserting intravesical cervical oses presented with cyclical haematuria. Work up revealed a mass in the ectopic cervical os and adjacent bladder wall. Subsequent resection confirmed a clear cell adenocarcinoma of urological origin with invasion into neighbouring os. PMID:26109625

  3. Seeing Clearly (A Cup of Health with CDC)

    Centers for Disease Control (CDC) Podcasts

    2014-05-08

    If you’re not seeing the world as clearly as you used to, you might be among the millions of people suffering from vision impairment. In this podcast, Dr. John Crews discusses ways to take care of your eyes.  Created: 5/8/2014 by MMWR.   Date Released: 5/8/2014.

  4. 31 CFR 50.12 - Clear and conspicuous disclosure.

    Science.gov (United States)

    2010-07-01

    ... INSURANCE PROGRAM Disclosures as Conditions for Federal Payment § 50.12 Clear and conspicuous disclosure. (a... circumstances of the disclosure. See § 50.17 for model forms. (b)(1) Description of premium. An insurer may..., consistent with the definition of an act of terrorism as amended by the Terrorism Risk Insurance...

  5. Clear Cell Chondrosarcoma in Association With Niemann-Pick Disease

    Directory of Open Access Journals (Sweden)

    K. N. Srikanth

    2005-01-01

    Full Text Available Purpose: The purpose of this case report is to bring to light this unusual combination of two rare diseases, namely Neimann-Pick disease Type B and clear cell chondrosarcoma occurring in the same patient. This has not previously been reported in the world literature.

  6. Bifunctional mesoporous silicas with clearly distinguished localization of grafted groups

    Science.gov (United States)

    Roik, N. V.; Belyakova, L. A.

    2013-12-01

    Bifunctional mesoporous silicas with clearly distinguished localization of grafted groups on the surface of particles and inside their pores were obtained by means of sol-gel synthesis with postsynthetic vapor-phase treatment in vacuum. It was found that the synthesized materials have the hexagonally ordered porous structure typical of MCM-41 type silica.

  7. Mathematical modeling of clearing liquid drop diffusion after intradermal injection

    Science.gov (United States)

    Stolnitz, Mikhail M.; Bashkatov, Alexey N.; Genina, Elina A.; Tuchin, Valery V.

    2007-05-01

    The mathematical model of clearing agent diffusion after intradermal injection has been developed. Skin was presented as multilayer medium, but one layer with proper boundary conditions is considered. Analytical solution of the boundary problem for small and large time intervals is obtained.

  8. The Search for Durable Exterior Clear Coatings for Wood

    Directory of Open Access Journals (Sweden)

    Philip D. Evans

    2015-11-01

    Full Text Available The goal of a durable exterior clear coating has eluded generations of coatings technologists, despite long-standing desire amongst the public for such a coating. The journey towards this goal initially focused on modifications to coating formulation, but took a completely different direction when it was found that a UV-transparent silicone clear coating on wood modified with chromic acid met consumer expectations of coating durability. This finding sparked world-wide interest in wood pre-treatments as a way of enhancing the durability of clear coatings. This interest initially focused on transition metal compounds, but has now shifted in the direction of organic and inorganic photostabilizers or even more drastic pre-treatments. Pre-treatments that dimensionally stabilize wood, protect it from microbial degradation and photostabilize lignin, when combined with flexible, photostable, coatings provide the next way-stop on the journey towards achieving the goal of durable exterior clear coatings for wood. This paper reviews this journey, drawing upon our research and that of other groups who have focused on this elusive goal.

  9. 76 FR 14471 - Clearing Agency Standards for Operation and Governance

    Science.gov (United States)

    2011-03-16

    ... CFTC have proposed rules to define these terms. See Exchange Act No. 63452 (December 7, 2010), 75 FR...-the- counter market. See Exchange Act Release No. 63825 (February 2, 2011), 76 FR 10948 (February 28... five entities to clear credit default swaps. See Exchange Act Release Nos. 60372 (July 23, 2009), 74...

  10. Clear cell variant of syringoma as a rare case

    Directory of Open Access Journals (Sweden)

    Özben Yalçın

    2014-12-01

    Full Text Available Syringoma is a benign skin tumor derived from eccrine glands characterized by yellowish-pink color and firm papular lesions of the skin especially on the lower eyelid. Typical histopathological features of syringoma are dilated cystic eccrine sweat gland ducts. In this paper, we report a case of clear cell variant syringoma with neck and trunk lesions.

  11. Treatment results and prognostic factors of clear cell ovarian carcinomas and ovarian carcinomas with clear cell component

    Directory of Open Access Journals (Sweden)

    M. D. Ahmedova

    2012-01-01

    Full Text Available The most important prognostic factors for clear cell carcinoma (CCC are clinical and morphological signs and clinical stage of the disease. Analyses of 5-year survival in patients with I stage of CCC is 69 %, in II stage – 55 %, in III stage – 14 % and in IV stage – 4 % patients. We analyzed distant results of treatment of 71 patients with CCC and of 25 patients with mixed malignant ovaries neoplasm with obligatory clear cell component taking into consideration main clinical and morphological sings of disease. On the base of performed reseal we revealed that morphological structure of the tumors and stage of the disease exerted heist influence on the exponent of survival of the patients with clear CCC ovaries neoplasm. Besides, there is a correlation between exponent of patients’ survival and radicalized of surgery, character of tumor growth, differentiation degree, cell anaplasia and mitotic activity of tumor cells.

  12. The potential of clear-sky carbon dioxide satellite retrievals

    Directory of Open Access Journals (Sweden)

    R. R. Nelson

    2015-12-01

    Full Text Available Since the launch of the Greenhouse Gases Observing Satellite (GOSAT in 2009, retrieval algorithms designed to infer the column-averaged dry-air mole fraction of carbon dioxide (XCO2 from hyperspectral near-infrared observations of reflected sunlight have been greatly improved. They now generally include the scattering effects of clouds and aerosols, as early work found that absorption-only retrievals, which neglected these effects, often incurred unacceptably large errors, even for scenes with optically thin cloud or aerosol layers. However, these "full-physics" retrievals tend to be computationally expensive and may incur biases from trying to deduce the properties of clouds and aerosols when there are none present. Additionally, algorithms are now available that can quickly and effectively identify and remove most scenes in which cloud or aerosol scattering plays a significant role. In this work, we test the hypothesis that non-scattering, or "clear-sky", retrievals may perform as well as full-physics retrievals for sufficiently clear scenes. Clear-sky retrievals could potentially avoid errors and biases brought about by trying to infer properties of clouds and aerosols when none are present. Clear-sky retrievals are also desirable because they are orders of magnitude faster than full-physics retrievals. Here we use a simplified version of the Atmospheric Carbon Observations from Space (ACOS XCO2 retrieval algorithm that does not include the scattering and absorption effects of clouds or aerosols. It was found that for simulated Orbiting Carbon Observatory-2 (OCO-2 measurements, the clear-sky retrieval had errors comparable to those of the full-physics retrieval. For real GOSAT data, the clear-sky retrieval had nearly indistinguishable error characteristics over land, but roughly 30–60 % larger errors over ocean, depending on filtration level, compared to the full-physics retrieval. In general, the clear-sky retrieval had XCO2 root

  13. 76 FR 5778 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2011-02-02

    ... stands, community-supported agriculture programs, and other direct producer-to-consumer infrastructure...; ] DEPARTMENT OF AGRICULTURE Submission for OMB Review; Comment Request January 28, 2011. The Department of Agriculture has submitted the following information collection requirement(s) to OMB for review and...

  14. 21 CFR 314.53 - Submission of patent information.

    Science.gov (United States)

    2010-04-01

    ... Cosmetic Act. This time-sensitive patent information is submitted pursuant to 21 CFR 314.53. I attest that I am familiar with 21 CFR 314.53 and this submission complies with the requirements of the... information is submitted pursuant to 21 CFR 314.53. I attest that I am familiar with 21 CFR 314.53 and...

  15. 78 FR 63987 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2013-10-25

    ... HUMAN SERVICES Administration for Children and Families Submission for OMB Review; Comment Request Title..., Research and Evaluation (OPRE), Administration for Children and Families (ACF), U.S. Department of Health... assessment of selected Responsible Fatherhood and Healthy Marriage grant programs that were authorized...

  16. 77 FR 38298 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2012-06-27

    ... HUMAN SERVICES Administration for Children and Families Submission for OMB Review; Comment Request Title... Families (ACF), U.S. Department of Health and Human Services is proposing an information collection activity as part of an evaluation of healthy marriage and responsible fatherhood grant programs....

  17. 77 FR 4328 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2012-01-27

    ... HUMAN SERVICES Administration for Children and Families Submission for OMB Review; Comment Request Title... for Children and Families (ACF), U.S. Department of Health and Human Services is proposing an information collection activity as part of an evaluation of healthy marriage and responsible fatherhood...

  18. 76 FR 53682 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2011-08-29

    ... HUMAN SERVICES Administration for Children and Families Submission for OMB Review; Comment Request Title... Planning, Research and Evaluation (OPRE), Administration for Children and Families (ACF), U.S. Department... fields of cash welfare, employment and self-sufficiency, Head Start, child care, healthy marriage...

  19. 75 FR 152 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2010-01-04

    ... HUMAN SERVICES Administration for Children and Families Submission for OMB Review; Comment Request Title... child's status, including termination from the program, within 60 days of the change or closure of the... be obtained by writing to the Administration for Children and Families, Office of...

  20. 40 CFR 52.16 - Submission to Administrator.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Submission to Administrator. 52.16... Administrator. (a) All requests, reports, applications, submittals, and other communications to the Administrator pursuant to this part shall be submitted in duplicate and addressed to the appropriate...

  1. 13 CFR 115.30 - Submission of Surety's guarantee application.

    Science.gov (United States)

    2010-01-01

    ... days, or in the case of a bonding line, within 15 business days (see § 115.33(d)(2)) after Execution of... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Submission of Surety's guarantee application. 115.30 Section 115.30 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SURETY...

  2. 76 FR 63281 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2011-10-12

    ... Submission for OMB Review; Comment Request The Department of Commerce will submit to the Office of Management... assessing participating laboratories to determine that they have the requisite technical competence and... ). Dated: October 5, 2011. Gwellnar Banks, Management Analyst, Office of the Chief Information...

  3. 78 FR 47016 - Submission for Review: Request for External Review

    Science.gov (United States)

    2013-08-02

    ... March 11, 2013, 78 FR 15560, which outlined an external review process that would be available to... MANAGEMENT Submission for Review: Request for External Review AGENCY: U.S. Office of Personnel Management... on a new information collection request (ICR) 3206-NEW, Request for External Review. As required...

  4. 76 FR 73741 - Submission for OMB Review; Comments Request

    Science.gov (United States)

    2011-11-29

    ... From the Federal Register Online via the Government Publishing Office OVERSEAS PRIVATE INVESTMENT CORPORATION Submission for OMB Review; Comments Request AGENCY: Overseas Private Investment Corporation (OPIC... information; the accuracy of the Agency's burden estimate; the quality, practical utility, and clarity of...

  5. 76 FR 38220 - Submission of OMB review; comments request

    Science.gov (United States)

    2011-06-29

    ... From the Federal Register Online via the Government Publishing Office OVERSEAS PRIVATE INVESTMENT CORPORATION Submission of OMB review; comments request AGENCY: Overseas Private Investment Corporation (OPIC... information; the accuracy of the Agency's burden estimate; the quality, practical utility and clarity of...

  6. 76 FR 38221 - Submission for OMB Review; Request for Comments

    Science.gov (United States)

    2011-06-29

    ... From the Federal Register Online via the Government Publishing Office OVERSEAS PRIVATE INVESTMENT CORPORATION Submission for OMB Review; Request for Comments AGENCY: Overseas Private Investment Corporation... information; the accuracy of the Agency's burden estimate, practical utility and clarity of the information...

  7. 76 FR 73740 - Submission for OMB Review; Comments Request

    Science.gov (United States)

    2011-11-29

    ... From the Federal Register Online via the Government Publishing Office OVERSEAS PRIVATE INVESTMENT CORPORATION Submission for OMB Review; Comments Request AGENCY: Overseas Private Investment Corporation (OPIC... information; the accuracy of the Agency's burden estimate; the quality, practical utility, and clarity of...

  8. 76 FR 20356 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2011-04-12

    ...; the National Child Abuse and Neglect Data System (NCANDS); Child Abuse Prevention and Treatment Act... to report specific information related to child abuse and neglect. CFR 1355.52 provides funding... HUMAN SERVICES Administration for Children and Families Submission for OMB Review; Comment Request...

  9. 77 FR 39496 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2012-07-03

    ..., Child Abuse and Neglect Program and the Child Welfare Training Program. Grantees will submit this... 45. Performance Measurement On-Line Tool Child Abuse and Neglect 2 per fiscal year One hour per... HUMAN SERVICES Administration for Children and Families Submission for OMB Review; Comment Request...

  10. 78 FR 24152 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2013-04-24

    ... better understanding of how international competition and the increasing knowledge intensity of economic... the national and global economics and provide USDA and other policymakers with sound information so... Submission for OMB Review; Comment Request April 18, 2013. The Department of Agriculture has submitted...

  11. 76 FR 40685 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2011-07-11

    ... institutions such as the Urban Institute, Peterson Institute for International Economics, Rand Corporation... Submission for OMB Review; Comment Request The Department of Commerce will submit to the Office of Management..., review and ] approval process as well as project tracking is managed with an Internet based...

  12. 77 FR 22763 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2012-04-17

    ... PROTECTION Submission for OMB Review; Comment Request AGENCY: Bureau of Consumer Financial Protection. ACTION... Financial Education Program that has been submitted to the Office of Management and Budget for review and... implementing a strategy to improve the financial literacy of consumers that includes measurable goals...

  13. 7 CFR 1726.35 - Submission of documents to RUS.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Submission of documents to RUS. 1726.35 Section 1726... of documents to RUS. (a) Where to send documents. Documents required to be submitted to RUS under this part are to be sent to the office of the borrower's respective RUS Regional Director, the...

  14. 28 CFR 512.14 - Submission and processing of proposal.

    Science.gov (United States)

    2010-07-01

    ... MANAGEMENT AND ADMINISTRATION RESEARCH Research § 512.14 Submission and processing of proposal. (a) An applicant may submit a preliminary research proposal for review by the Office of Research and Evaluation... operational staff, to evaluate the proposal for compliance with research policy, and to make...

  15. 75 FR 21040 - Submission for OMB Review: Comment Request

    Science.gov (United States)

    2010-04-22

    ...: 640. Total Estimated Annual Costs Burden: $0. Description: This survey will assess public attitudes... (DOL) hereby announces the submission of the following public information collection request (ICR) to....gov/public/do/PRAMain or by contacting Darrin King on 202- 693-4129 (this is not a toll-free...

  16. 77 FR 4373 - Submission for OMB Review; Comments Request

    Science.gov (United States)

    2012-01-27

    ... From the Federal Register Online via the Government Publishing Office OVERSEAS PRIVATE INVESTMENT CORPORATION Submission for OMB Review; Comments Request AGENCY: Overseas Private Investment Corporation (OPIC... U.S.C. Chapter 35), agencies are required to publish a Notice in the Federal Register notifying...

  17. 76 FR 73740 - Submission for OMB Review; Comments Request

    Science.gov (United States)

    2011-11-29

    ... From the Federal Register Online via the Government Publishing Office OVERSEAS PRIVATE INVESTMENT CORPORATION Submission for OMB Review; Comments Request AGENCY: Overseas Private Investment Corporation (OPIC... U.S.C. Chapter 35), agencies are required to publish a Notice in the Federal Register notifying...

  18. 77 FR 4372 - Submission for OMB Review; Comments Request

    Science.gov (United States)

    2012-01-27

    ... From the Federal Register Online via the Government Publishing Office OVERSEAS PRIVATE INVESTMENT CORPORATION Submission for OMB Review; Comments Request AGENCY: Overseas Private Investment Corporation (OPIC... U.S.C. Chapter 35), agencies are required to publish a Notice in the Federal Register notifying...

  19. 76 FR 73741 - Submission for OMB Review; Comments Request

    Science.gov (United States)

    2011-11-29

    ... From the Federal Register Online via the Government Publishing Office OVERSEAS PRIVATE INVESTMENT CORPORATION Submission for OMB Review; Comments Request AGENCY: Overseas Private Investment Corporation (OPIC... U.S.C. Chapter 35), agencies are required to publish a Notice in the Federal Register notifying...

  20. 76 FR 74834 - Submission for OMB Review; comments request

    Science.gov (United States)

    2011-12-01

    ... From the Federal Register Online via the Government Publishing Office OVERSEAS PRIVATE INVESTMENT CORPORATION Submission for OMB Review; comments request AGENCY: Overseas Private Investment Corporation (OPIC... U.S.C. ] Chapter 35), agencies are required to publish a Notice in the Federal Register...

  1. 76 FR 17163 - Submission for OMB Review-Comment Request

    Science.gov (United States)

    2011-03-28

    ... From the Federal Register Online via the Government Publishing Office OVERSEAS PRIVATE INVESTMENT CORPORATION Submission for OMB Review--Comment Request AGENCY: Overseas Private Investment Corporation (OPIC.... chapter 35), agencies are required to publish a Notice in the Federal Register notifying the public...

  2. 76 FR 17164 - Submission of OMB Review; Comments Request

    Science.gov (United States)

    2011-03-28

    ... From the Federal Register Online via the Government Publishing Office OVERSEAS PRIVATE INVESTMENT CORPORATION Submission of OMB Review; Comments Request AGENCY: Overseas Private Investment Corporation (OPIC.... Chapter 35), agencies are required to publish a Notice in the Federal Register notifying the public...

  3. 76 FR 17163 - Submission of OMB Review; Comments Request

    Science.gov (United States)

    2011-03-28

    ... From the Federal Register Online via the Government Publishing Office OVERSEAS PRIVATE INVESTMENT CORPORATION Submission of OMB Review; Comments Request AGENCY: Overseas Private Investment Corporation (OPIC.... Chapter 35), agencies are required to publish a Notice in the Federal Register notifying the public...

  4. 77 FR 4374 - Submission for OMB Review; Comments Request

    Science.gov (United States)

    2012-01-27

    ... From the Federal Register Online via the Government Publishing Office OVERSEAS PRIVATE INVESTMENT CORPORATION Submission for OMB Review; Comments Request AGENCY: Overseas Private Investment Corporation (OPIC... U.S.C. Chapter 35), agencies are required to publish a Notice in the Federal Register notifying...

  5. 76 FR 17162 - Submission of OMB Review; Comments Request

    Science.gov (United States)

    2011-03-28

    ... From the Federal Register Online via the Government Publishing Office OVERSEAS PRIVATE INVESTMENT CORPORATION Submission of OMB Review; Comments Request AGENCY: Overseas Private Investment Corporation (OPIC.... Chapter 35), agencies are required to publish a Notice in the Federal Register notifying the public...

  6. 78 FR 18305 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2013-03-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Submission for OMB Review; Comment Request March 20, 2013. The Department of Agriculture has submitted the... for implementing and enforcing the P&S Act, including the swine contract library. The...

  7. 21 CFR 1002.7 - Submission of data and reports.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Submission of data and reports. 1002.7 Section 1002.7 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED..., or model family of the same product category, a “common aspects report” consolidating...

  8. 77 FR 56214 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2012-09-12

    ... child care providers/ teachers, and two for parents) have been developed, based on a literature review, a review of existing measures, and information collected through focus groups (under OMB Clearance... HUMAN SERVICES Administration for Children and Families Submission for OMB Review; Comment Request...

  9. 78 FR 47749 - Submission of Questionnaire for OMB Review

    Science.gov (United States)

    2013-08-06

    ... COMMISSION Submission of Questionnaire for OMB Review AGENCY: United States International Trade Commission... request for approval of a questionnaire to the Office of Management and Budget for review. Purpose of Information Collection: The information requested by the questionnaire is for use by the Commission...

  10. Universities UK Submission to the 2010 Spending Review

    Science.gov (United States)

    Universities UK, 2010

    2010-01-01

    This document represents the submission of Universities UK to the 2010 Spending Review. It sets out why the authors believe universities are critical to the UK's future economic growth, what the impact of cuts to the budget for higher education would be, and the activities which universities are currently pursuing to secure national economic…

  11. 78 FR 13014 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2013-02-26

    ...: Submission of Itineraries OMB Control Number: 0579-0361 Summary of Collection: The Animal Welfare Act (AWA) was first enacted as the Laboratory Animal Welfare Act (LAWA) (Pub. L. 89-544) on August 24, 1966, and... legislation and its amendments were the results of extensive demand by organized animal welfare groups...

  12. 78 FR 24184 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2013-04-24

    ... submit a patent application under the PCT and by the USPTO to fulfill its obligation to process, search... Patent and Trademark Office Submission for OMB Review; Comment Request The United States Patent and....C. Chapter 35). Agency: United States Patent and Trademark Office (USPTO). Title: Patent...

  13. 75 FR 8038 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2010-02-23

    ... submit a patent application under the PCT and by the USPTO to fulfill its obligation to process, search... Patent and Trademark Office Submission for OMB Review; Comment Request The United States Patent and....C. Chapter 35). Agency: United States Patent and Trademark Office (USPTO). Title: Patent...

  14. 78 FR 12744 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2013-02-25

    ... patent applications and may also search sequence listings after publication. Affected Public: Businesses... United States Patent and Trademark Office Submission for OMB Review; Comment Request The United States Patent and Trademark Office (USPTO) will submit to the Office of Management and Budget (OMB)...

  15. 77 FR 77015 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2012-12-31

    ... crisis situation because of incompatible communications networks and often outdated communications... Submission for OMB Review; Comment Request The Department of Commerce will submit to the Office of Management...._Fraser@omb.eop.gov . Dated: December 21, 2012. Gwellnar Banks, Management Analyst, Office of the...

  16. 21 CFR 1316.59 - Submission and receipt of evidence.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Submission and receipt of evidence. 1316.59 Section 1316.59 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE ADMINISTRATIVE... the witness is properly qualified. (c) The authenticity of all documents submitted in advance shall...

  17. 28 CFR 901.2 - Interpretation of fingerprint submission requirements.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Interpretation of fingerprint submission requirements. 901.2 Section 901.2 Judicial Administration NATIONAL CRIME PREVENTION AND PRIVACY COMPACT COUNCIL... identification with requests for criminal history record checks for noncriminal justice purposes. The...

  18. Assessing Impact Submissions for REF 2014: An Evaluation

    Science.gov (United States)

    Manville, Catriona; Guthrie, Susan; Henham, Marie-Louise; Garrod, Bryn; Sousa, Sonia; Kirtley, Anne; Castle-Clarke, Sophie; Ling, Tom

    2015-01-01

    The Research Excellence Framework (REF) is a new system for assessing the quality of research in UK higher education institutions (HEIs). For the first time, part of the assessment included the wider impact of research. RAND Europe was commissioned to evaluate the assessment process of the impact element of REF submissions, and to explore the…

  19. 32 CFR 199.7 - Claims submission, review, and payment.

    Science.gov (United States)

    2010-07-01

    .../medical documentation. Medical records are of vital importance in the care and treatment of the patient... necessary for the accurate and efficient administration of CHAMPUS benefits. This may include requests for...) Claims filed by providers using CHAMPUS-approved signature-on-file and claims submission procedures....

  20. 78 FR 13399 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2013-02-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY Submission for OMB Review; Comment Request February 21, 2013. The Department of the Treasury will submit the following information collection request to the Office of Management and Budget (OMB) for review and clearance in accordance with...

  1. 29 CFR 301.5 - Form of submission.

    Science.gov (United States)

    2010-07-01

    ... submitted in exhibit form, quoting the agreement or rules involved, if any; and all data submitted in..., including all documentary evidence submitted in exhibit form, quoting the agreement or rules involved, if... Board of intention to file an ex parte submission on a certain date (30 days hence), and at the...

  2. 78 FR 42752 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2013-07-17

    ... Submission for OMB Review; Comment Request The Department of Commerce will submit to the Office of Management... actions, but will inform future management actions requiring equivalent information. Literature indicates... . Copies of the above information collection proposal can be obtained by calling or writing Jennifer...

  3. 50 CFR 270.3 - Submission of application.

    Science.gov (United States)

    2010-10-01

    ... setting forth the definition of a quorum for making decisions on Council business and the procedures for... the Council; (xviii) A provision containing a requirement for submission to NMFS the criteria and supporting data for evaluating the annual and/or multi-year performance of proposed marketing plans and...

  4. 76 FR 64079 - Notice of Submission for OMB Review

    Science.gov (United States)

    2011-10-17

    ..., including the validity of the methodology and assumptions used; (3) Enhance the quality, utility, and... and research purposes. Copies of the information collection submission for OMB review may be accessed... Internet address ICDocketMgr@ed.gov or faxed to 202-401-0920. Please specify the complete title of...

  5. 41 CFR 109-50.402 - Submission of proposals.

    Science.gov (United States)

    2010-07-01

    ... 50-SPECIAL DOE DISPOSAL AUTHORITIES 50.4-Programmatic Disposal to Contractors of DOE Property in a Mixed Facility § 109-50.402 Submission of proposals. Proposals involving programmatic disposals of DOE..., acquisition cost, and present use of the DOE personal property involved. (c) The programmatic benefits...

  6. 76 FR 33703 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2011-06-09

    ... Response: 20 minutes. Needs and Uses: The Office of Technology and Electronic Commerce in the Manufacturing... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Submission for OMB Review; Comment Request The Department of Commerce will submit to the Office of...

  7. The letter of submission: avoiding the promotional genre

    DEFF Research Database (Denmark)

    Shaw, Philip; Okamura, Akiko

    1998-01-01

    Functionally the letter of submission accompanying an article submitted to a journal is promotional, but it does not have the form one would expect from e.g. Bhatia 1993. Instead it is extremely brief and uninformative. This reflects the so-called Utilitarian Discourse which is a shared feature...

  8. 76 FR 9541 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2011-02-18

    ... Submission for OMB Review; Comment Request The Department of Commerce will submit to the Office of Management... business surveys ] represent the primary source of facts about the structure and function of the U.S. economy, providing essential information to government and the business community in making...

  9. 75 FR 38773 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2010-07-06

    ... Submission for OMB Review; Comment Request The Department of Commerce will submit to the Office of Management... provisions of the Paperwork Reduction Act (44 U.S.C. chapter 35). Agency: U.S. Census Bureau. Title: Business... business surveys represent the primary source of facts about the structure and function of the U.S....

  10. 78 FR 65963 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2013-11-04

    ... Submission for OMB Review; Comment Request The Department of Commerce will submit to the Office of Management... Administration (NOAA). Title: Survey of Fish Processors and Business Disruptions Caused by Hurricane Sandy. OMB... on distribution networks and business practices from fish processors that process groundfish and...

  11. 77 FR 69434 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2012-11-19

    ... Submission for OMB Review; Comment Request The Department of Commerce will submit to the Office of Management... defined in 15 CFR part 285, Sec. 285.14. The information provides a service to customers in business and...: Business or other for-profit organizations; not- for-profit institutions; and Federal, State or...

  12. 76 FR 3877 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2011-01-21

    ... Submission for OMB Review; Comment Request The Department of Commerce will submit to the Office of Management... emergency provisions of the Paperwork Reduction Act (44 U.S.C. chapter 35). Agency: Minority Business Development Agency (MBDA). Title: Minority Business Center Program: Communication and Outreach. OMB...

  13. 78 FR 52499 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2013-08-23

    ... Conservation and Management Act. Affected Public: Business or other for-profit organizations. Frequency: Weekly... Submission for OMB Review; Comment Request The Department of Commerce will submit to the Office of Management..., and managers in the management of the fisheries. The data collection parameters are consistent...

  14. 28 CFR 100.16 - Cost estimate submission.

    Science.gov (United States)

    2010-07-01

    ... utilized in the carrier's efforts to meet CALEA requirements. (v) Other costs. List all other costs not... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Cost estimate submission. 100.16 Section 100.16 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) COST RECOVERY...

  15. 76 FR 12934 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2011-03-09

    ... Submission for OMB Review; Comment Request The Department of Commerce will submit to the Office of Management... review is for the U.S. Census Bureau to obtain clearance from the Office of Management and Budget (OMB... to the publication of all labor force data in the BLS' monthly report Employment and Earnings....

  16. 77 FR 36276 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2012-06-18

    ... HUMAN SERVICES Administration for Children and Families Submission for OMB Review; Comment Request Title... Children and Families (ACF), U.S. Department of Health and Human Services (HHS) is proposing data... program. The information collection proposed will supplement internet-based collection of information...

  17. 76 FR 35220 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2011-06-16

    ... HUMAN SERVICES Administration for Children and Families Submission for OMB Review; Comment Request Title... (HPOG). OMB No.: New Collection. Description: The Administration for Children and Families (ACF) is... HPOG grantees on a regular basis. The information collection proposed is an Internet-based...

  18. 77 FR 4541 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2012-01-30

    ... Submission for OMB Review; Comment Request The Department of Commerce will submit to the Office of Management... reports, 10 minutes, and documentary evidence requests by the NOAA Fisheries, Southwest Region....gov . Dated: January 24, 2012. Gwellnar Banks, Management Analyst, Office of the Chief...

  19. AIDS and journalism. Trying to tell too clear a story.

    Science.gov (United States)

    Cohen, J

    1994-12-01

    Much in science is complex. Scientists, by definition, work within the realm of complex hypothesis, empirical evidence, and proof. Questions, answers, details, complexities; that is the domain of the scientist. Journalists, on the other hand, are paid to develop and present stories which are clearly read and interpreted by the general public. The mechanics and dynamics of HIV and AIDS are among the most complex scientific challenges in the history of humankind. Journalists calling upon scientists to obtain and report clear, concise, information about the agent and its resulting pandemic are therefore surely not always going to receive simple, readily reportable responses. HIV is a moving target upon which research continues. While there are some definitively affirmative and some definitively negative factors about HIV, the gray areas and speculation remain vast. The author gives a few examples of AIDS stories which the media mishandled because they were trying to tell too clear a story. He then discusses stories flawed because scientists managed to present clear information about which journalists were overly skeptical. In one case, the public was informed that AIDS vaccines were not working, with headlines which insinuated that the vaccines themselves were causing infections. None of the vaccines, however, contained infectious materials. As a result, people became overly fearful of participating in HIV vaccine trials. Coverage of the potential identification of HIV-3 was premature and only scared people, while Rolling Stone magazine's article hypothesizing the origin of HIV via trials of a contaminated polio vaccine in the Belgium Congo in the late 1950s should not have been published. Clear answers about HIV/AIDS are few and far between, but interesting and significant stories can still be found; they are just hard to tell. PMID:12319130

  20. Clear cell ovarian cancer and endometriosis: is there a relationship?

    Science.gov (United States)

    Suzin, Jacek; Obirek, Katarzyna; Sochacka, Amanda; Łoszakiewicz, Marta

    2016-01-01

    Introduction Ovarian clear cell carcinoma is a rare type of ovarian cancer. In recent years, issues of the common genetic origin of endometriosis and ovarian clear cell carcinoma have been raised. Aim of this study Aim of this study was to evaluate the prevalence of this type of cancer, risk factors, prognosis and its potential aetiological association with endometriosis. Material and methods In a retrospective study, we analysed histopathological data of patients operated in the First Department of Gynaecology and Obstetrics (MU, Lodz) due to ovarian cancer in 2004-2014. Among the 394 patients operated on for ovarian cancer, clear cell carcinoma was found in 0.02% (9/394). Menstrual history, parity, comorbidities, data from physical examination, operational protocols and histopathological diagnoses were analysed. Follow-up was obtained from 77.8% of patients. Statistical analysis was performed using Microsoft Excel 2013. Results The mean age of patients at diagnosis was 57.6 years; the BMI in the study group was 27.2; the majority of patients were multiparous (77.8%). Clear cell carcinoma was detected mostly at stage Ia (n = 4). The concentration of Ca125 in the study group had an average of 142.75 U/ml and a median of 69.3 U/ml. The coexistence of endometriosis could not be clinically or histologically confirmed amongst our patients. The most common comorbidity in the study group was hypertension. Conclusions In our clinical material, ovarian clear cell carcinoma is a rare histopathological specimen with a prognostic value comparable to that of serous ovarian cancer. Due to the rarity of this histopathological subtype, proving a cause-and-effect relationship between it and endometriosis can only be elucidated through statistical studies of the entire population.

  1. Relationship of submissive behavior and cyberbullying/cybervictimization: The mediation role of gender

    Directory of Open Access Journals (Sweden)

    Adem Peker

    2012-01-01

    Full Text Available The purpose of this study is to investigate the mediating role of gender in relationship between submissive behavior and cyber bullying/cyber victimization. The sample included 193 female and 137 male. Data were obtained using Submissive Behavior Scale and Revized Cyberbullying Inventory and analyzed by SPSS 11.5. Hierarchical regression was used to explore the mediating role of gender in relationship between submissive behavior and cyber bullying/cyber victimization. According to results, submissive behavior was positively related to cyber bullying and cyber victimization. In addition gender was found to fully mediate the relationship between submissive behavior and cyber bullying. However, gender failed to mediate the effects of submissive behavior on cyber victimization.

  2. Relationship of submissive behavior and cyberbullying/cybervictimization: The mediation role of gender

    Directory of Open Access Journals (Sweden)

    Adem Peker

    2012-01-01

    Full Text Available The purpose of this study is to investigate the mediating role of gender in relationship between submissive behavior and cyber bullying/cyber victimization. The sample included 193 female and 137 male. Data were obtained using Submissive Behavior Scale and Revized Cyberbullying Inventory and analyzed by SPSS 11.5. Hierarchical regression was used to explore the mediating role of gender in relationship between submissive behavior and cyber bullying/cyber victimization. According to results, submissive behavior was positively related to cyber bullying and cyber victimization. In addition gender was found to fully mediate the relationship between submissive behavior and cyber bullying. However, gender failed to mediate the effects of submissive behavior on cyber victimization. 

  3. 78 FR 54507 - Clearing Agency; the Options Clearing Corporation; Notice of Filing of Proposed Rule Change To...

    Science.gov (United States)

    2013-09-04

    ..., including number of outstanding shares, number of outstanding shareholders and overall trading volume. The... collateral for a particular clearing member, shares of an otherwise eligible security held as margin. II... market price ofconcentrated security positions by identifying the two individual securities whose...

  4. 78 FR 72729 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing and Immediate...

    Science.gov (United States)

    2013-12-03

    ... would not unfairly inhibit access to OCC's services or disadvantage or favor any particular user in... following methods: ] Electronic Comments Use the Commission's Internet comment form ( http://www.sec.gov... one method of submission. The Commission will post all comments on the Commission's Internet Web...

  5. Clear cell change in a lower lip mucocele.

    Science.gov (United States)

    Piña, Alicia Rumayor; Almeida, Luciana Yamamoto; Andrade, Bruno Augusto Benevenuto; León, Jorge Esquiche

    2013-05-01

    Oral mucocele is a common reactive lesion of the oral mucosa, which microscopically exhibits mucus extravasation surrounded by a wall of granulation tissue containing abundant foamy macrophages. Unusual variants, such as superficial mucoceles, mucoceles with myxoglobulosis-like change and mucoceles with synovial metaplasia-like change have been reported. We report a 74-year-old man who presented an asymptomatic translucent swelling on the lower labial mucosa diagnosed as mucocele showing a macrophage proliferation with extensive clear cytoplasmic vacuolation and signet-ring formation. This unusual presentation expands the microscopic spectrum of the oral mucoceles and can eventually lead to differential diagnosis with primary or metastatic clear cell neoplasms. In these cases, relevant clinical information, histochemistry and especially immunohistochemistry, are helpful for arriving at an accurate diagnosis. PMID:24250103

  6. Clear cell change in a lower lip mucocele

    Directory of Open Access Journals (Sweden)

    Alicia Rumayor Piña

    2013-01-01

    Full Text Available Oral mucocele is a common reactive lesion of the oral mucosa, which microscopically exhibits mucus extravasation surrounded by a wall of granulation tissue containing abundant foamy macrophages. Unusual variants, such as superficial mucoceles, mucoceles with myxoglobulosis-like change and mucoceles with synovial metaplasia-like change have been reported. We report a 74-year-old man who presented an asymptomatic translucent swelling on the lower labial mucosa diagnosed as mucocele showing a macrophage proliferation with extensive clear cytoplasmic vacuolation and signet-ring formation. This unusual presentation expands the microscopic spectrum of the oral mucoceles and can eventually lead to differential diagnosis with primary or metastatic clear cell neoplasms. In these cases, relevant clinical information, histochemistry and especially immunohistochemistry, are helpful for arriving at an accurate diagnosis.

  7. Effects of Mixing on Hopper Sedimentation in Clearing Mixtures

    DEFF Research Database (Denmark)

    Hjelmager Jensen, Jacob; Saremi, Sina

    2015-01-01

    and settling in high-concentration mixtures were examined theoretically. Analytical solutions for clearance of excess concentrations were derived for the limiting cases of (1) still-water clearance and (2) clearance when the amount of turbulence is abundant. When examining these analytical solutions......Hopper sedimentation is the result of precipitation of typically fine sediment from a homogenous, high-concentration mixture, which is not completely deficient of turbulence. If hopper sedimentation or loading is accomplished through a single-inflow system, or if the irregularity of the inflow...... concentrations is pronounced or simply terminated, then the hopper mixture will clear. Whereas turbulent mixing is redundant, when the mixture is homogeneous, it may take an active role when the mixture is clearing. The role of turbulence on hopper sedimentation has been the focus of several studies...

  8. Clear sky atmosphere at cm-wavelengths from climatology data

    CERN Document Server

    Lew, Bartosz

    2015-01-01

    We utilise ground-based, balloon-born and satellite climatology data to reconstruct site and season-dependent vertical profiles of precipitable water vapour (PWV). We use these profiles to numerically solve radiative transfer through the atmosphere, and derive atmospheric brightness temperature ($T_{\\rm atm}$) and optical depth ($\\tau$) at the centimetre wavelengths. We validate the reconstruction by comparing the model column PWV, with photometric measurements of PWV, performed in the clear sky conditions towards the Sun. Based on the measurements, we devise a selection criteria to filter the climatology data to match the PWV levels to the expectations of the clear sky conditions. We apply the reconstruction to the location of the Polish 32-metre radio telescope, and characterise $T_{\\rm atm}$ and $\\tau$ year-round, at selected frequencies. We also derive the zenith distance dependence for these parameters, and discuss shortcomings of using planar, single-layer, and optically thin atmospheric model approxima...

  9. OCT monitoring of diffusion of clearing agents within tooth dentin

    Science.gov (United States)

    Trunina, N. A.; Lychagov, V. V.; Tuchin, V. V.

    2009-08-01

    Monitoring of agent diffusion within tooth tissues is important in a wide context of tooth therapy (diffusion of medicinal preparations) and cosmetics (chemical whitening agents). We report here the results of optical coherence tomography (OCT) monitoring of diffusion of water and glycerol as clearing agents in samples of human tooth tissue. The diffusion process is analyzed by monitoring the changes in the OCT signal slope and the depth-resolved amplitude of OCT signal from a sample. Slow temporal kinetics of the mean attenuation coefficient was measured to monitor a saturable optical clearing due to the diffusion of the agent. The average permeability coefficient was estimated by dividing the measured thickness of the selected region by the time it took for the agent to diffuse through. The experimental results demonstrate that OCT can be an efficient tool in the study of agent diffusion through hard tissues.

  10. Clear cell sarcoma of the kidney: A case report

    Directory of Open Access Journals (Sweden)

    Dipanwita Nag

    2014-01-01

    Full Text Available Clear cell sarcoma of the kidney is a rare malignant neoplasm of childhood, known for its aggressiveness, its tendency for recurrence, and to metastasize to bone. We report the observation of 8-month-old child presenting with a large abdominal mass. Clinically, it was diagnosed as Wilm′s tumor, and left nephrectomy was done. Grossly, 10 cm × 8 cm × 3.5 cm globular, white, encapsulated, smooth mass uniformly involving the whole kidney was noted. Histologically, the tumor was diagnosed as clear cell sarcoma with renal vein showing presence of tumor embolus in lumen. The tumor was given stage-II (NWTS-5 protocol. Immunohistochemistry showed vimentin positive and cytokeratin negative tumor cells. The child is currently undergoing chemotherapy and has not yet shown any sign of bony metastasis.

  11. 77 FR 10765 - Notice of Submission of Proposed Information Collection to OMB; Multifamily Financial Management...

    Science.gov (United States)

    2012-02-23

    ... generally accepted accounting principles, in a prescribed format. Electronic submissions of this data... participants to submit financial data electronically, using generally accepted accounting principles, in...

  12. Agroforestry is promising for previously cleared hardwood rangelands

    OpenAIRE

    McCreary, Doug

    2001-01-01

    Livestock grazing is the primary economic use of most hardwood rangelands in the coastal foothills of California. But owners of these lands may be able to increase revenues by simultaneously producing two crops, trees and sheep. In 1993, we initiated an agroforestry project at the UC Hopland Research and Extension Center to study the ability of three pine species and one hybrid to grow on cleared hardwood rangelands that are grazed by sheep. This study also evaluated the response of planted s...

  13. Image reconstruction for the ClearPETTM Neuro

    International Nuclear Information System (INIS)

    ClearPETTM is a family of small-animal PET scanners which are currently under development within the Crystal Clear Collaboration (CERN). All scanners are based on the same detector block design using individual LSO and LuYAP crystals in phoswich configuration, coupled to multi-anode photomultiplier tubes. One of the scanners, the ClearPETTM Neuro is designed for applications in neuroscience. Four detector blocks with 64 2x2x10 mm LSO and LuYAP crystals, arranged in line, build a module. Twenty modules are arranged in a ring with a ring diameter of 13.8 cm and an axial size of 11.2 cm. An insensitive region at the border of the detector heads results in gaps between the detectors axially and tangentially. The detectors are rotating by 360o in step and shoot mode during data acquisition. Every second module is shifted axially to compensate partly for the gaps between the detector blocks in a module. This unconventional scanner geometry requires dedicated image reconstruction procedures. Data acquisition acquires single events that are stored with a time mark in a dedicated list mode format. Coincidences are associated off line by software. After sorting the data into 3D sinograms, image reconstruction is performed using the Ordered Subset Maximum A Posteriori One-Step Late (OSMAPOSL) iterative algorithm implemented in the Software for Tomographic Image Reconstruction (STIR) library. Due to the non-conventional scanner design, careful estimation of the sensitivity matrix is needed to obtain artifact-free images from the ClearPETTM Neuro

  14. Clear Cell Chondrosarcoma in Association With Niemann-Pick Disease

    OpenAIRE

    Sumathi, V. P.; Grimer, R. J.; Davies, A. M.; Kulkarni, A.; Srikanth, K. N.

    2005-01-01

    Purpose: The purpose of this case report is to bring to light this unusual combination of two rare diseases, namely Neimann-Pick disease Type B and clear cell chondrosarcoma occurring in the same patient. This has not previously been reported in the world literature. Subject: Niemann-Pick disease (NPD) is a rare autosomal recessive inborn error of metabolism. Type B NPD is even rarer. It is a lysosomal storage disorder affecting children and adolescents often causing death in early childhood,...

  15. Clear-Air Propagation Modeling using Parabolic Equation Method

    Directory of Open Access Journals (Sweden)

    V. Kvicera

    2003-12-01

    Full Text Available Propagation of radio waves under clear-air conditions is affected bythe distribution of atmospheric refractivity between the transmitterand the receiver. The measurement of refractivity was carried out onthe TV Tower Prague to access evolution of a refractivity profile. Inthis paper, the parabolic equation method is used in modelingpropagation of microwaves when using the measured data. This paperbriefly describes the method and shows some practical results ofsimulation of microwave propagation using real vertical profiles ofatmospheric refractivity.

  16. Clear sky atmosphere at cm-wavelengths from climatology data

    OpenAIRE

    Lew, Bartosz; Uscka-Kowalkowska, Joanna

    2015-01-01

    We utilise ground-based, balloon-borne and satellite climatology data to reconstruct site and season-dependent vertical profiles of precipitable water vapour (PWV). We use these profiles to solve radiative transfer through the atmosphere, and derive atmospheric brightness temperature ($T_{\\rm atm}$) and optical depth ($\\tau$) at centimetre wavelengths. We validate the reconstruction by comparing the model column PWV with photometric measurements of PWV, performed in clear sky conditions point...

  17. Durational cues to word boundaries in clear speech

    OpenAIRE

    Cutler, A.; Butterfield, S.

    1990-01-01

    One of a listener’s major tasks in understanding continuous speech in segmenting the speech signal into separate words. When listening conditions are difficult, speakers can help listeners by deliberately clear speech. We found that speakers do indeed attempt to makr word boundaries; moreover, they differentiate between word boundaries in a way which suggest they are sensitive to listener needs. Application of heuristic segmentation strategies makes word boundaries before strong syllables eas...

  18. ClearFuels-Rentech Integrated Biorefinery Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Pearson, Joshua [Project Director

    2014-02-26

    The project Final Report describes the validation of the performance of the integration of two technologies that were proven individually on a pilot scale and were demonstrated as a pilot scale integrated biorefinery. The integrated technologies were a larger scale ClearFuels’ (CF) advanced flexible biomass to syngas thermochemical high efficiency hydrothermal reformer (HEHTR) technology with Rentech’s (RTK) existing synthetic gas to liquids (GTL) technology.

  19. Experimental characterization of the Clear-PEM scanner spectrometric performance

    Science.gov (United States)

    Bugalho, R.; Carriço, B.; Ferreira, C. S.; Frade, M.; Ferreira, M.; Moura, R.; Ortigão, C.; Pinheiro, J. F.; Rodrigues, P.; Rolo, I.; Silva, J. C.; Trindade, A.; Varela, J.

    2009-10-01

    In the framework of the Clear-PEM project for the construction of a high-resolution and high-specificity scanner for breast cancer imaging, a Positron Emission Mammography tomograph has been developed and installed at the Instituto Português de Oncologia do Porto hospital. The Clear-PEM scanner is mainly composed by two planar detector heads attached to a robotic arm, trigger/data acquisition electronics system and computing servers. The detector heads hold crystal matrices built from 2 × 2 × 20 mm3 LYSO:Ce crystals readout by Hamamatsu S8550 APD arrays. The APDs are optically coupled to both ends of the 6144 crystals in order to extract the DOI information for each detected event. Each one of 12288 APD's pixels is read and controlled by Application Specific Integrated Circuits water-cooled by an external cooling unit. The Clear-PEM frontend boards innovative design results in a unprecedented integration of the crystal matrices, APDs and ASICs, making Clear-PEM the PET scanner with the highest number of APD pixels ever integrated so far. In this paper, the scanner's main technical characteristics, calibration strategies and the first spectrometric performance evaluation in a clinical environment are presented. The first commissioning results show 99.7% active channels, which, after calibration, have inter-pixel and absolute gain distributions with dispersions of, respectively, 12.2% and 15.3%, demonstrating that despite the large number of channels, the system is uniform. The mean energy resolution at 511 keV is of 15.9%, with a 8.8% dispersion, and the mean CDOI-1 is 5.9%/mm, with a 7.8% dispersion. The coincidence time resolution, at 511 keV, for a energy window between 400 and 600 keV, is 5.2 ns FWHM.

  20. Temporal co-registration for TROPOMI cloud clearing

    Directory of Open Access Journals (Sweden)

    I. Genkova

    2012-03-01

    Full Text Available The TROPOspheric Monitoring Instrument (TROPOMI is anticipated to provide high-quality and timely global atmospheric composition information through observations of atmospheric constituents such as ozone, nitrogen dioxide, sulfur dioxide, carbon monoxide, methane, formaldehyde and aerosol properties. The methane and the aerosol retrievals require very precise cloud clearing, which is difficult to achieve at the TROPOMI spatial resolution (7 by 7 km and without thermal IR measurements. The TROPOMI carrier – the Sentinel 5 Precursor (S5P, does not include a cloud imager, thus it is planned to fly the S5P mission in a constellation with an instrument yielding an accurate cloud mask. The cloud imagery data will be provided by the US NPOESS Preparatory Project (NPP mission, which will have the Visible Infrared Imager Radiometer Suite (VIIRS on board (Scalione, 2004. This paper investigates the temporal co-registration requirements for suitable time differences between the VIIRS measurements of clouds and the TROPOMI methane and aerosol measurements, so that the former could be used for cloud clearing. The temporal co-registration is studied using Meteosat Second Generation (MSG Spinning Enhanced Visible and Infrared Imager (SEVIRI data with 15 min temporal resolution (Veefkind, 2008b, and with data from the Geostationary Operational Environmental Satellite – 10 (GOES-10 having 1 min temporal resolution. The aim is to understand and assess the relation between the amount of allowed cloud contamination and the required time difference between the two satellites' overflights. Quantitative analysis shows that a time difference of approximately 5 min is sufficient (in most conditions to use the cloud information from the first instrument for cloud clearing in the retrievals using data from the second instrument. In recent years the A-train constellation demonstrated the benefit of flying satellites in formation. Therefore this study's findings will be

  1. Identifying fly puparia by clearing technique: application to forensic entomology.

    Science.gov (United States)

    Sukontason, Kabkaew L; Ngern-Klun, Radchadawan; Sripakdee, Duanghatai; Sukontason, Kom

    2007-10-01

    In forensic investigations, immature stages of the fly (egg, larva, or puparia) can be used as entomological evidence at death scenes, not only to estimate the postmortem interval (PMI), analyze toxic substances, and to determine the manner of death but also to indicate the movement of a corpse in homicide cases. Of these immature stages, puparia represent the longest developmental time, which makes them of useful. However, in order for forensic entomologists to use puparia effectively, it is crucial that they are able to accurately identify the species of fly found in a corpse. Typically, these puparia are similar in general appearance, being coarctate and light brown to dark brown in color, which makes identification difficult. In this study, we report on the clearing technique used to pale the integument of fly puparia, thereby allowing observation of the anterior end (second to fourth segments) and the profile of the posterior spiracle, which are important clues for identification. We used puparia of the blowfly, Chrysomya megacephala (F.), as the model species in this experiment. With placement in a 20% potassium hydroxide solution daily and mounting on a clearing medium (Permount(R), New Jersey), the profile of the posterior spiracle could be clearly examined under a light microscope beginning on the fifth day after pupation, and the number of papillae in the anterior spiracle could be counted easily starting from the ninth day. Comparison of morphological features of C. megacephala puparia with those of other blowflies (Chrysomya nigripes [Aubertin], Chrysomya rufifacies [Macquart], Chrysomya villeneuvi [Patton], Lucilia cuprina [Wiedemann], and Hemipyrellia ligurriens [Wiedemann]) and a housefly (Musca domestica L.) revealed that the anterior ends and the profiles of the posterior spiracles had markedly distinguishing characteristics. Morphometric analysis of the length and width of puparia, along with the length of the gaps between the posterior spiracles

  2. Cerebellar clear cell ependymoma in a 10 year old girl

    Energy Technology Data Exchange (ETDEWEB)

    Thinzar Aye Nyein; Moon, Ah Rim; Hwang, Sun Chul; Hong, Hyun Sook; Lee, A Leum; Chang, Kee Hyun; Kim, Hee Kyung; Chin, Su Sie [Soonchunhyang University Bucheon Hospital, Bucheon (Korea, Republic of); Park, Ji Sang [Soonchunhyang University Gumi Hospital, Gumi (Korea, Republic of)

    2016-01-15

    Clear cell ependymoma (CCE) is a histological rare variant (1–5%) of ependymoma, which is distinguished from other histological subtypes by the presence of fusiform cells arrayed radially around small blood vessels. These alleged perivascular pseudorosettes are significant characteristic features of ependymomas. About 95% of infratentorial ependymomas are found in the fourth ventricle and the remainder occurs as cerebellopontine angle lesions. In previous reports, the cerebellum is found to be a rare location for ependymoma. In this study we report one case of CCE originating from the cerebellar hemisphere, showing unusual morphology on 3T MRI.

  3. Optical clearing and multiphoton imaging of paraffin-embedded specimens

    Science.gov (United States)

    Wilson, Jesse W.; Degan, Simone; Fischer, Martin C.; Warren, Warren S.

    2013-02-01

    New labeling, imaging, or analysis tools could provide new retrospective insights when applied to archived, paraffin-embedded samples. Deep-tissue multiphoton microscopy of paraffin-embedded specimens is achieved using optical clearing with mineral oil. We tested a variety of murine tissue specimens including skin, lung, spleen, kidney, and heart, acquiring multiphoton autofluorescence and second-harmonic generation, and pump-probe images This technique introduces the capability for non-destructive 3-dimensional microscopic imaging of existing archived pathology specimens, enabling retrospective studies.

  4. Clear Sky Index : Framtagen med enkortsdator och webbkamera

    OpenAIRE

    Enström, Oskar; Klavebäck, Erik; Muhrbeck, Rasmus

    2015-01-01

    A future sustainable society need to rely more on renewable energy sources. One of the most promising alternatives is solar power. However, there are inherent fluctuations accompanied with solar power, for example if the shadow of a cloud blocks the sun light on a whole solar cell it will not produce any power. This will cause problems with connecting the solar panels to the power grid. Clear sky index (CSI) is a measurement of how much of the sky that is covered by clouds, and is a key param...

  5. A new computational method for reactive power market clearing

    International Nuclear Information System (INIS)

    After deregulation of electricity markets, ancillary services such as reactive power supply are priced separately. However, unlike real power supply, procedures for costing and pricing reactive power supply are still evolving and spot markets for reactive power do not exist as of now. Further, traditional formulations proposed for clearing reactive power markets use a non-linear mixed integer programming formulation that are difficult to solve. This paper proposes a new reactive power supply market clearing scheme. Novelty of this formulation lies in the pricing scheme that rewards transformers for tap shifting while participating in this market. The proposed model is a non-linear mixed integer challenge. A significant portion of the manuscript is devoted towards the development of a new successive mixed integer linear programming (MILP) technique to solve this formulation. The successive MILP method is computationally robust and fast. The IEEE 6-bus and 300-bus systems are used to test the proposed method. These tests serve to demonstrate computational speed and rigor of the proposed method. (author)

  6. Primary abdominal wall clear cell carcinoma arising from incisional endometriosis

    Institute of Scientific and Technical Information of China (English)

    Burcu Gundogdu; Isin Ureyen; Gunsu Kimyon; Hakan Turan; Nurettin Boran; Gokhan Tulunay; Dilek Bulbul; Taner Turan; M Faruk Kose

    2013-01-01

    A 49 year-old patient with the complaint of a mass located in the caesarean scar was admitted. There was a fixed mass 30í30 mm in diameter with regular contour located at the right corner of the pfannenstiel incision. Computed tomography revealed a (40í50í50) mm solid mass lesion with margins that cannot be distinguished from the uterus, bladder and small intestines and a heterogeneous mass lesion (50í45í55) mm in diameter, located in the right side of the anterior abdominal wall. Cytoreductive surgery including total abdominal hysterectomy and bilateral salpingo-oophorectomy was performed. Final pathology was clear cell carcinoma. Clear cell carcinoma arising from an extraovarian endometriotic focus was diagnosed and the patient received 6 cycles paclitaxel-carboplatin chemotherapy as adjuvant treatment. The patient who was lost to follow-up applied to our clinic 2 years after surgery with a recurrent mass in the left inguinal region. After 3 cycles of chemotherapy, the patient's tumoral mass in the left inguinal region was excised. The result of the pathology was carcinoma metastasis. It is decided that the following treatment of the patient should be palliative radiation therapy. The patient who underwent palliative radiation therapy died of disease after 4 months of the second operation.

  7. A giant benign clear cell hidradenoma on the anterior trunk

    Directory of Open Access Journals (Sweden)

    Damlanur Sakiz

    2011-10-01

    Full Text Available Clear cell hidroadenoma (CCA is a uncommon variant of bening cutaneous adnexial tumors. These tumors are clinically asymptomatic, solitary dermal nodules. they occur most frequently on the scalp, face, abdomen and the extremities. Growth is slow and malignant change is rare. 45- year-old woman presented us with a nodule with a central ulceration and a minimal hemoragic discharge on her anterior abdomen wall which had begun 4 years ago as a small nodular asymptomatic lesion. On dermatological examination there was a 6.5x4x5 cm non-tender, soft reddish purple nodule with lobular appearence and ulceration. In the laboratory investigations, all the hematologic and biochemical tests were normal. A CT scan demonstrated a cyctic tumor with lobulated countour with contrast enhancement. The lesion excised totally. In histopathological examination the tumor was composed of biphasic  smaller dark polygonal cells and larger clera cells and coarse nuclear chromatine. There were duct like structures. Immunohistochemical investigation was done for the suspicion of malignancy. Cytoplasm of clear cells and duct like structures showed PAS positive and d-Pas resistant staining. There was a positive reactivity to epithelial membrane antigen and carcinoembrionic antigen. The mitotic index in Ki 67 examination was low. All these findings confirmed the diagnosis of bening CCA. 

  8. APLIKASI SIX SIGMA PADA PRODUK CLEAR FILE DI PERUSAHAAN STATIONARY

    Directory of Open Access Journals (Sweden)

    Desy Emilasari

    2007-01-01

    Full Text Available This paper describes the application of the Six Sigma methods is used in order to improve quality in manufacturing company that produce stationary product. DMAIC approach is utilized to analyze and improve 'Pocket Clear File' product since this product has more variability and defects. Quality improvement also monitor the process that influenced pocket defect in Bag Making, Kami-ire, Karidome, and Pocket after Karidome Inspections section. Determining of Six Sigma project is based in process and defect type in each section. FMEA also gave the recommendation for quality improvement we need to evaluate the final result of the improvement since some of them were not working properly. Abstract in Bahasa Indonesia : Paper ini menggambarkan bagaimana aplikasi metode Six Sigma digunakan untuk melakukan perbaikan kualitas pada perusahaan manufaktur yang memproduksi produk stationary. Pendekatan DMAIC dipakai untuk menganalisa dan melakukan perbaikan produk 'Pocket Clear File' karena tingginya variabilitas dan cacat dibanding produk lain. Perbaikan kualitas juga memperhatikan proses yang mempengaruhi terjadinya cacat pocket pada section Bag Making, Kami-ire, Karidome, dan Pocket after Karidome Inspection. Penentuan proyek Six Sigma didasarkan atas proses dan jenis cacat pada setiap section. Pendekatan FMEA mampu memberi rekomendasi perbaikan kualitas. Evaluasi dari hasil perbaikan penting untuk dilakukan karena beberapa implementasi perbaikan kualitas tidak berjalan sesuai dengan rencana. kata kunci: six sigma, DMAIC, perusahaan stationary.

  9. Code Generation for Embedded Software for Modeling Clear Box Structures

    Directory of Open Access Journals (Sweden)

    V. Chandra Prakash

    2011-09-01

    Full Text Available Cleanroom software Engineering (CRSE recommended that the code related to the Application systems be generated either manually or through code generation models or represents the same as a hierarchy of clear box structures. CRSE has even advocated that the code be developed using the State models that models the internal behavior of the systems. No framework has been recommended by any Author using which the Clear boxes are designed using the code generation methods. Code Generation is one of the important quality issues addressed in cleanroom software engineering. It has been investigated that CRSE can be used for life cycle management of the embedded systems when the hardware-software co-design is in-built as part and parcel of CRSE by way of adding suitable models to CRSE and redefining the same. The design of Embedded Systems involves code generation in respect of hardware and Embedded Software. In this paper, a framework is proposed using which the embedded software is generated. The method is unique that it considers various aspects of the code generation which includes Code Segments, Code Functions, Classes, Globalization, Variable propagation etc. The proposed Framework has been applied to a Pilot project and the experimental results are presented.

  10. Statistical functions and relevant correlation coefficients of clearness index

    Science.gov (United States)

    Pavanello, Diego; Zaaiman, Willem; Colli, Alessandra; Heiser, John; Smith, Scott

    2015-08-01

    This article presents a statistical analysis of the sky conditions, during years from 2010 to 2012, for three different locations: the Joint Research Centre site in Ispra (Italy, European Solar Test Installation - ESTI laboratories), the site of National Renewable Energy Laboratory in Golden (Colorado, USA) and the site of Brookhaven National Laboratories in Upton (New York, USA). The key parameter is the clearness index kT, a dimensionless expression of the global irradiance impinging upon a horizontal surface at a given instant of time. In the first part, the sky conditions are characterized using daily averages, giving a general overview of the three sites. In the second part the analysis is performed using data sets with a short-term resolution of 1 sample per minute, demonstrating remarkable properties of the statistical distributions of the clearness index, reinforced by a proof using fuzzy logic methods. Successively some time-dependent correlations between different meteorological variables are presented in terms of Pearson and Spearman correlation coefficients, and introducing a new one.

  11. Clear cell carcinoma arising from a uterus-like mass.

    Science.gov (United States)

    Nakakita, Baku; Abiko, Kaoru; Mikami, Yoshiki; Kido, Aki; Baba, Tsukasa; Yoshioka, Yumiko; Yamaguchi, Ken; Matsumura, Noriomi; Konishi, Ikuo

    2014-11-01

    A uterus-like mass is an extrauterine mass with a cavity lined by endometrial tissue and a smooth muscle layer resembling the uterine corpus. It is a rare condition of unknown histogenesis. Herein, we describe a case of clear cell carcinoma arising from a uterus-like mass located in the retroperitoneal space. The patient, a 67-year old nulliparous woman, had been followed with the diagnosis of an ovarian endometriotic cyst for 14 years until ultrasonography and magnetic resonance imaging (MRI) demonstrated an enlargement of the cystic mass with a thickened irregular wall. Suspicion of malignant transformation prompted us to excise the lesion. At laparotomy, the uterus and right ovary appeared normal, and a mass measuring 8 cm was identified in the retroperitoneal space without any connection to the uterus. Grossly, the removed mass was composed of a cyst filled with blackish-brownish fluid and a thick wall resembling uterine myometrium. Microscopically, endometrial tissue inside the cyst, which was diffusely lined by clear cell carcinoma, was identified. Although the histogenesis of a uterus-like mass remains unclear, this case indicates that malignant tumors may occur from a uterus-like mass through the pathway similar to the carcinogenesis of endometriosis-related ovarian neoplasms.

  12. Clear Cell Adenocarcinoma of the Urethra: Review of the Literature

    Directory of Open Access Journals (Sweden)

    Anthony Kodzo-Grey Venyo

    2015-01-01

    Full Text Available Background. Clear cell adenocarcinoma of the urethra (CCAU is extremely rare and a number of clinicians may be unfamiliar with its diagnosis and biological behaviour. Aims. To review the literature on CCAU. Methods. Various internet databases were used. Results/Literature Review. (i CCAU occurs in adults and in women in the great majority of cases. (ii It has a particular association with urethral diverticulum, which has been present in 56% of the patients; is indistinguishable from clear cell adenocarcinoma of the female genital tract but is not associated with endometriosis; and probably does not arise by malignant transformation of nephrogenic adenoma. (iii It is usually, readily distinguished from nephrogenic adenoma because of greater cytological a-typicality and mitotic activity and does not stain for prostate-specific antigen or prostatic acid phosphatase. (iv It has been treated by anterior exenteration in women and cystoprostatectomy in men and at times by radiotherapy; chemotherapy has rarely been given. (v CCAU is aggressive with low 5-year survival rates. (vi There is no consensus opinion of treatment options that would improve the prognosis. Conclusions. Few cases of CCAU have been reported. Urologists, gynaecologists, pathologists, and oncologists should report cases of CCAU they encounter and enter them into a multicentric trial to determine the best treatment options that would improve the prognosis.

  13. Where should I send it? Optimizing the submission decision process.

    Directory of Open Access Journals (Sweden)

    Santiago Salinas

    Full Text Available How do scientists decide where to submit manuscripts? Many factors influence this decision, including prestige, acceptance probability, turnaround time, target audience, fit, and impact factor. Here, we present a framework for evaluating where to submit a manuscript based on the theory of Markov decision processes. We derive two models, one in which an author is trying to optimally maximize citations and another in which that goal is balanced by either minimizing the number of resubmissions or the total time in review. We parameterize the models with data on acceptance probability, submission-to-decision times, and impact factors for 61 ecology journals. We find that submission sequences beginning with Ecology Letters, Ecological Monographs, or PLOS ONE could be optimal depending on the importance given to time to acceptance or number of resubmissions. This analysis provides some guidance on where to submit a manuscript given the individual-specific values assigned to these disparate objectives.

  14. A Web portal for CMS Grid job submission and management

    International Nuclear Information System (INIS)

    We present a Web portal for CMS Grid submission and management. The portal is built using a JBoss application server. It has a three tier architecture; presentation, business logic and data. Bean based business logic interacts with the underlying Grid infrastructure and pre-existing external applications, while the presentation layer uses AJAX to offer an intuitive, functional interface to the back-end. Application data aggregating information from the portal as well as the external applications is persisted to the server memory cache and then to a backend database. We describe how the portal exploits standard, off-the-shelf commodity software together with existing Grid infrastructures in order to facilitate job submission and monitoring for the CMS collaboration. This paper describes the design, development, current functionality and plans for future enhancements of the portal.

  15. 17 CFR 12.105 - Submission of proof only in documentary or tangible form.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Submission of proof only in documentary or tangible form. 12.105 Section 12.105 Commodity and Securities Exchanges COMMODITY FUTURES....105 Submission of proof only in documentary or tangible form. Proof in support of the complaint and...

  16. 76 FR 28852 - Agency Information Collection (Regulation for Submission of Evidence); Activity Under OMB Review

    Science.gov (United States)

    2011-05-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF VETERANS AFFAIRS Agency Information Collection (Regulation for Submission of Evidence); Activity Under OMB Review... INFORMATION: Title: Regulation for Submission of Evidence--Title 38 CFR 17.101(a)(4). OMB Control Number:...

  17. 76 FR 13022 - Proposed Information Collection (Regulation for Submission of Evidence); Comment Request

    Science.gov (United States)

    2011-03-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF VETERANS AFFAIRS Proposed Information Collection (Regulation for Submission of Evidence); Comment Request AGENCY...: Regulation for Submission of Evidence--Title 38 CFR 17.101(a)(4). OMB Control Number: 2900-0606. Type...

  18. 41 CFR 105-54.203-3 - Submission to Library of Congress.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Submission to Library of... Submission to Library of Congress. The GSA Committee Management Officer furnishes a copy of each charter to the Library of Congress when or shortly after copies are filed with the requisite committees of...

  19. 22 CFR 214.38 - Submission of reports to the Library of Congress.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Submission of reports to the Library of... MANAGEMENT Operation of Advisory Committees § 214.38 Submission of reports to the Library of Congress. (a) Each advisory committee is to file with the Library of Congress eight copies of each of its...

  20. 76 FR 8371 - Notice Correction; Generic Submission of Technology Transfer Center (TTC) External Customer...

    Science.gov (United States)

    2011-02-14

    ... HUMAN SERVICES National Institutes of Health Notice Correction; Generic Submission of Technology Transfer Center (TTC) External Customer Satisfaction Surveys (NCI) The Federal Register notice published on December 23, 2010 (75 FR 80830) announcing the submission to OMB of the project titled,...

  1. 10 CFR 1016.5 - Submission of procedures by access permit holder.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Submission of procedures by access permit holder. 1016.5 Section 1016.5 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) SAFEGUARDING OF RESTRICTED DATA General Provisions § 1016.5 Submission of procedures by access permit holder. No access permit holder shall...

  2. Investigation of the Effect of Sport on Submissive Behavior and Communication Skills of High School Students

    Science.gov (United States)

    Abakay, Ugur

    2013-01-01

    This study was carried out to detect the differences in submissive behaviors and communication skills of high school students in terms of sports activities and relationship between communication skills and properties of submissive behavior of high school students who are actively involved in sports activities. In this respect at the study, 728…

  3. 77 FR 41206 - Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB...

    Science.gov (United States)

    2012-07-12

    ... COMMISSION Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB... collection on April 13, 2012 (77 FR 22360). 1. Type of submission, new, revision, or extension: Extension. 2... into how NRC can make its services and products cost effective, efficient and responsive to...

  4. 48 CFR 49.304-2 - Submission of settlement proposal (fee only).

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Submission of settlement proposal (fee only). 49.304-2 Section 49.304-2 Federal Acquisition Regulations System FEDERAL ACQUISITION... Contracts Terminated for Convenience 49.304-2 Submission of settlement proposal (fee only). The...

  5. 49 CFR 1152.36 - Submission of revenue and cost data.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Submission of revenue and cost data. 1152.36... AND RAIL TRANSPORTATION UNDER 49 U.S.C. 10903 Standards for Determining Costs, Revenues, and Return on Value § 1152.36 Submission of revenue and cost data. The following information shall be submitted...

  6. 76 FR 19121 - Notice of Submission of Proposed Information Collection to OMB Multifamily Project Applications...

    Science.gov (United States)

    2011-04-06

    ... mortgage insurance. Project owners/sponsors may apply for permission to commence construction prior to... collection techniques or other forms of information technology, e.g., permitting electronic submission of... apply for permission to commence construction prior to initial endorsement. Frequency of Submission:...

  7. 48 CFR 52.214-34 - Submission of Offers in the English Language.

    Science.gov (United States)

    2010-10-01

    ... the English Language. 52.214-34 Section 52.214-34 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.214-34 Submission of Offers in the English Language. As prescribed in 14.201-6(w), insert the following provision: Submission of Offers in the English Language (APR 1991) Offers...

  8. 12 CFR Appendix IV to Part 27 - Home Loan Data Submission

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Home Loan Data Submission IV Appendix IV to Part 27 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY FAIR HOUSING HOME LOAN DATA SYSTEM Pt. 27, App. IV Appendix IV to Part 27—Home Loan Data Submission ER21JN94.003...

  9. 78 FR 70954 - Transport Format for the Submission of Regulatory Study Data; Notice of Pilot Project

    Science.gov (United States)

    2013-11-27

    ... HUMAN SERVICES Food and Drug Administration Transport Format for the Submission of Regulatory Study Data...) transport format for the submission of regulatory study data. The current study data transport format supported by FDA is the SAS Transport (XPORT) version 5 file format. Although XPORT has been a...

  10. 48 CFR 252.232-7003 - Electronic submission of payment requests and receiving reports.

    Science.gov (United States)

    2010-10-01

    ... PROVISIONS AND CONTRACT CLAUSES Text of Provisions And Clauses 252.232-7003 Electronic submission of payment... administering the contract for payment has determined, in writing, that electronic submission would be unduly... non-electronic payment requests using the method or methods specified in Section G of the contract....

  11. 78 FR 10215 - Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB...

    Science.gov (United States)

    2013-02-13

    ... collection on October 17, 2012 (77 FR 63893). 1. Type of submission, new, revision, or extension: Extension... COMMISSION Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB... annually to complete the requirement or request: 59,782 (54,208 hrs. reporting + 1 hr....

  12. 75 FR 52954 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

    Science.gov (United States)

    2010-08-30

    ... Master File in Support of Petitions; Electronic Submission Using Food and Drug Administration Form 3503 AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA... HUMAN SERVICES Food and Drug Administration Agency Information Collection Activities; Submission...

  13. 76 FR 45588 - Notice of Submission of Proposed Information Collection to OMB; Innovation of the Day

    Science.gov (United States)

    2011-07-29

    ...: Innovation of the Day. OMB Approval Number: 2528-Pending. Form Numbers: None. Description of the Need for the... URBAN DEVELOPMENT Notice of Submission of Proposed Information Collection to OMB; Innovation of the Day... subject proposal. ``Innovation of the Day'' is a new online submission and display platform located on...

  14. 40 CFR 24.14 - Scheduling the hearing; pre-hearing submissions by the parties.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Scheduling the hearing; pre-hearing submissions by the parties. 24.14 Section 24.14 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Hearings on Orders Requiring Corrective Measures § 24.14 Scheduling the hearing; pre-hearing submissions...

  15. 76 FR 7874 - Notice of Proposed Information Collection for Public Comment on the Online Innovation Submission...

    Science.gov (United States)

    2011-02-11

    ... URBAN DEVELOPMENT Notice of Proposed Information Collection for Public Comment on the Online Innovation Submission Form for the Innovation of the Day Project AGENCY: Office of Policy Development and Research, HUD... submission of responses). This Notice also lists the following information: Title of Proposal: Innovation...

  16. 76 FR 14995 - Comment Request for Information Collection for Work-Flex Plan Submission and Reporting...

    Science.gov (United States)

    2011-03-18

    ... Request for Information Collection for Work-Flex Plan Submission and Reporting Requirements; Extension... data about the Work Flex Plan Submission and Reporting Requirements. A copy of the proposed information... five years pursuant to a Work-Flex Plan submitted by a state. Under Work-Flex, governors are...

  17. 77 FR 34955 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

    Science.gov (United States)

    2012-06-12

    ... if such use is not intended to have any technical effect in such food.'' Section 409(h)(3) of the FD... substances except when: (1) FDA determines that the submission and premarket review of a food additive..., interested persons transmit an FCN submission to the Office of Food Additive Safety in the Center for...

  18. 5 CFR 2604.601 - Electronic posting and submission of annual OGE FOIA report.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Electronic posting and submission of annual OGE FOIA report. 2604.601 Section 2604.601 Administrative Personnel OFFICE OF GOVERNMENT ETHICS... FINANCIAL DISCLOSURE REPORTS Annual OGE FOIA Report § 2604.601 Electronic posting and submission of...

  19. Enabling Successful Submissions of Scientific Data for Preservation and Future Use

    Science.gov (United States)

    Downs, R. R.; Chen, R. S.

    2009-12-01

    Preparing scientific data and research-related information for submission to a scientific data archive or digital repository for long-term preservation and dissemination is a critical task for data stewardship, but can be challenging for those who have produced data initially for their own use. We describe here a data submission system designed to assist data producers in preparing and describing their data in ways that balance the need for comprehensive information about the data with the practicalities of what data producers are willing and able to provide. The system is based on a model for web-based services that enables self-submission and supports the workflow needed for gathering the information required for long-term preservation and use by current and future research, education, and decision-making communities. To inform the design of the system for a range of data types, submissions of both Earth and social science data sets were analyzed to identify successful practices that could be implemented in a self-submission system. We describe these successful data submission practices along with the features of a self-submission system that should help encourage the submission of scientific data by both natural and social scientists.

  20. 47 CFR 2.956 - FCC inspection and submission of equipment for testing.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false FCC inspection and submission of equipment for testing. 2.956 Section 2.956 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL FREQUENCY... Verification § 2.956 FCC inspection and submission of equipment for testing. (a) Each responsible party...

  1. 47 CFR 2.1076 - FCC inspection and submission of equipment for testing.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false FCC inspection and submission of equipment for testing. 2.1076 Section 2.1076 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL FREQUENCY... Declaration of Conformity § 2.1076 FCC inspection and submission of equipment for testing. (a)...

  2. Interactive Multi-Submission Deposit Workflows for Desktop Applications

    OpenAIRE

    Tarrant, David; Carr, Les; Wade, Alex; Warner, Simeon

    2010-01-01

    Online submission and publishing is the norm for academic researchers. With the pressure on these authors to submit their work to conferences, journals and Institutional Repositories, this leads to de- mands on the author to go through multiple web based interfaces, filling in forms with the same information multiple times before they can sub- mit. At the same time, each of these services in turn will have made pol- icy decisions on what types of format they allow and what templates the conte...

  3. NCC Submission to the Commission on Taxation, June 2008

    OpenAIRE

    2008-01-01

    A Commission on Taxation has been established to review the structure, efficiency and appropriateness of the Irish taxation system. The NCC prepared the following submission. It highlights the importance of taxation policy to competitiveness, and calls for further actions to assess how the taxation system can promote the development of the knowledge economy. It also highlights the importance of maintaining Ireland’s competitive labour tax wedge and the need to review property taxation.

  4. Predicting the Resource Requirements of a Job Submission

    OpenAIRE

    Ali, Arshad; Anjum, Ashiq; Bunn, Julian; Cavanaugh, Richard; van Lingen, Frank; McClatchey, Richard; Mehmood, Muhammad Atif; Newman, Harvey; Steenberg, Conrad; Thomas, Michael; Willers, Ian

    2004-01-01

    Grid computing aims to provide an infrastructure for distributed problem solving in dynamic virtual organizations. It is gaining interest among many scientific disciplines as well as the industrial community. However, current grid solutions still require highly trained programmers with expertise in networking, high-performance computing, and operating systems. One of the big issues in full-scale usage of a grid is matching the resource requirements of job submission to the r...

  5. Temporal co-registration for TROPOMI cloud clearing

    Directory of Open Access Journals (Sweden)

    I. Genkova

    2011-10-01

    Full Text Available The TROPOspheric Monitoring Instrument (TROPOMI is planed for launch in 2014 on board of the Sentinel 5 Precursor (S5P and is anticipated to provide high-quality and timely information on the global atmospheric composition for climate and air quality applications. TROPOMI will observe key atmospheric constituents such as ozone, nitrogen dioxide, sulfur dioxide, carbon monoxide, methane, formaldehyde and aerosol properties. The retrieval algorithms for the anticipated products require cloud information on a pixel basis. Most of them will use the cloud properties derived from TROPOMI's own measurements, such as the O2 A-band measurements. However, the methane and the aerosol retrievals require very precise cloud clearing, which is difficult to achieve at the TROPOMI spatial resolution (7 × 7 km2 and without thermal IR measurements. The current payload of the Sentinel 5 Precursor (S-5P does not include a cloud imager, thus it is planned to fly the S5P mission in a constellation with another instrument yielding an accurate cloud mask. The cloud imagery data will be provided by the US NPOESS Preparatory Project (NPP mission which will have the Visible Infrared Imager Radiometer Suite (VIIRS on board (Scalione, 2004. VIIRS will have 22 bands in the VIS and IR spectral ranges, and will deliver data with two spatial resolutions: imagery resolution bands with a nominal pixel size of 370 m at nadir, and moderate resolution bands with nominal pixel size 740 m at nadir. The instrument is combining fine spatial resolution with high-accuracy calibration similar or superior to AVHRR.

    This paper presents results from investigating the temporal co-registration requirements for suitable time differences between the VIIRS measurements of clouds and the TROPOMI methane and aerosol measurements, so that the former could be used for cloud clearing. The temporal co-registration is studied using Meteosat Second Generation (MSG Spinning

  6. Use of Digital Image Technology to 'Clearly' Depict Global Change

    Science.gov (United States)

    Molnia, B. F.; Carbo, C. L.

    2014-12-01

    Earth is dynamic and beautiful. Understanding why, when, how, and how fast its surface changes yields information and serves as a source of inspiration. The artistic use of geoscience information can inform the public about what is happening to their planet in a non-confrontational and apolitical way. While individual images may clearly depict a landscape, photographic comparisons are necessary to clearly capture and display annual, decadal, or century-scale impacts of climate and environmental change on Earth's landscapes. After years of effort to artistically communicate geoscience concepts with unenhanced individual photographs or pairs of images, the authors have partnered to maximize this process by using digital image enhancement technology. This is done, not to manipulate the inherent artistic content or information content of the photographs, but to insure that the comparative photo pairs produced are geometrically correct and unambiguous. For comparative photography, information-rich historical photographs are selected from archives, websites, and other sources. After determining the geographic location from which the historical photograph was made, the original site is identified and eventually revisited. There, the historical photos field of view is again photographed, ideally from the original location. From nearly 250 locations revisited, about 175 pairs have been produced. Every effort is made to reoccupy the original historical site. However, vegetation growth, visibility reduction, and co-seismic level change may make this impossible. Also, inherent differences in lens optics, camera construction, and image format may result in differences in the geometry of the new photograph when compared to the old. Upon selection, historical photos are cleaned, contrast stretched, brightness adjusted, and sharpened to maximize site identification and information extraction. To facilitate matching historical and new images, digital files of each are overlain in

  7. The palm oil supply chain, deforestation and peat clearing

    Science.gov (United States)

    Boucher, D. H.

    2013-12-01

    The palm oil industry has expanded rapidly in the last two decades, particularly in Indonesia. A considerable amount of this expansion has been at the expense of forests and peatlands, resulting in considerable greenhouse gas emissions. Now the industry is faced with two new challenges. There is a possible oversupply on the global market due to recent expansion and the time lag between clearing and new production coming on line, which may depress prices considerably. Furthermore, there is increasing pressure to reduce the industry's impact on climate and biodiversity, exemplified by the commitment by the businesses of the Consumer Goods Forum to eliminate deforestation from their supply chains by 2020. This presentation will examine the interaction between these two challenges and its implications for the industry, in both southeast Asia and new regions of expansion, and how this interaction could transform the industry's mode of expansion in the coming decade.

  8. Simulating colors of clear and partly cloudy skies.

    Science.gov (United States)

    Gedzelman, Stanley David

    2005-09-20

    A model (SKYCOLOR) is developed that simulates the light and color of the sky and open cloud decks in the vertical plane including the Sun and the observer and animates the changes as the Sun goes down. Model skylight consists of sunbeams that are scattered toward the observer, but depleted by scattering and absorption in the Chappuis bands of ozone. SKYCOLOR includes the Earth's curvature, atmospheric refraction, cloud shadows, and solar eclipses. Scattering is given a wavelength (lambda) dependence of lambda(-4) for air molecules (Rayleigh scattering), lambda(-1) for tropospheric aerosols, and lambda(+1) for volcanic aerosol particles. Multiple scattering is calculated directly in clouds but is parameterized in clear air by decreasing the scattering rates of sunlight and of skylight in the Earth's shadow by 30%. PMID:16201435

  9. Interpretation of MST radar returns from clear air

    Science.gov (United States)

    Liu, C. H.

    1983-01-01

    The nature of the scattering and reflection mechanisms that give rise to the MST radar echoes from the clear air is essential in the correct interpretation of the data about winds, waves, turbulence and stability in the atmosphere. There are two main aspects: the nature of the targets the radar sees and their generation mechanisms; and the signatures of the radar signals returned from the different targets. Volume scatterings from isotropic or anisotropic turbulence, and partial reflections from horizontally stratified, sharp refractive index gradients are believed the main contributors to radar echoes. Combined effects from all the mechanisms probably produce the observed data. The signature of the echo signals for these different scatterers under realistic experimental conditions should be studied. It is hoped from these studies, the nature of the targets can be better understood, and related to atmospheric dynamic processes.

  10. All-clear for gourmets: truffles not radioactive

    Science.gov (United States)

    Büntgen, U.; Jäggi, M.; Stobbe, U.; Tegel, W.; Sproll, L.; Eikenberg, J.; Egli, S.

    2016-02-01

    Although ranging among the most expensive gourmet foods, it remains unclear whether Burgundy truffles (Tuber aestivum) accumulate radioactivity at a harmful level comparable to other fungal species. Here, we measure the 137Cs in 82 T. aestivum fruit bodies from Switzerland, Germany, France, Italy, and Hungary. All tested specimens reveal insignificant radiocaesium concentrations, thus providing an all-clear for many truffle hunters and cultivators in large parts of Europe as well as the subsequent chain of dealers and customers from around the world. Our results are particularly relevant in the light of ongoing efforts to cultivate Burgundy truffles, as well as the fact that several forest ecosystems are still highly contaminated with 137Cs, for which mushrooms are one of the main pathways to human diets.

  11. Proposal for a project agreement with ISTC - Crystal Clear Collaboration

    CERN Document Server

    2001-01-01

    This document concerns a project agreement with the ISTC entitled "Development of the Detector Production Technology for a New Generation of Positron Emission Tomographs to be used in Medecine and Pharmacology" to be executed in co-operation with the Crystal Clear Collaboration. For the reasons set out in this document, the Finance Committee is invited to agree to the negotiation of a project agreement with ISTC for a total amount of 775 000 US dollars. The European Union party in ISTC will co-fund the project up to a total of 525 000 US dollars. CERN's contribution will not exceed 250 000 US dollars. At the present rate of exchange this is equivalent to approximately 430 000 Swiss francs

  12. Clear cell chondrosarcoma mimicking chondroblastoma in a skeletally immature patient

    Energy Technology Data Exchange (ETDEWEB)

    Cannon, Christopher P. [Department of Orthopaedic Surgery, Madigan Army Medical Center, Ft. Lewis, WA (United States); Nelson, Scott D. [Department of Pathology and Laboratory Medicine, University of California, Los Angeles School of Medicine, CA (United States); Seeger, Leanne L. [Department of Radiological Sciences, University of California, CA (United States); Eckardt, Jeffrey J. [Department of Orthopaedic Surgery, University of California, Los Angeles School of Medicine, CA (United States)

    2002-06-01

    We report the case of a clear cell chondrosarcoma (CCCS) occurring in the femoral head of a 14-year-old skeletally immature boy. Radiographic examination revealed a well-defined, osteolytic lesion in the epiphysis of the femoral head. Given the patient's age and the radiographic appearance of the lesion, chondroblastoma was high on the differential diagnosis. A frozen section was performed at the time of open biopsy was felt to be consistent with either chondroblastoma or CCCS. CCCS in a skeletally immature patient was felt to be unlikely, so curettage and bone grafting was performed. Final pathology review, however, confirmed the diagnosis of CCCS. The patient was taken back to surgery 4 weeks later for a wide resection and hemiarthroplasty. (orig.)

  13. Clear Cell Adenocarcinoma Arising from Abdominal Wall Endometriosis

    Directory of Open Access Journals (Sweden)

    Thouraya Achach

    2008-01-01

    Full Text Available Endometriosis is a frequent benign disorder. Malignancy arising in extraovarian endometriosis is a rare event. A 49-year-old woman is presented with a large painful abdominal wall mass. She underwent a myomectomy, 20 years before, for uterus leiomyoma. Computed tomography suggested that this was a desmoid tumor and she underwent surgery. Histological examination showed a clear cell adenocarcinoma associated with endometriosis foci. Pelvic ultrasound, computed tomography, and endometrial curettage did not show any malignancy or endometriosis in the uterus and ovaries. Adjuvant chemotherapy was recommended, but the patient was lost to follow up. Six months later, she returned with a recurrence of the abdominal wall mass. She was given chemotherapy and then she was reoperated.

  14. Temperature gradients and clear-air turbulence probabilities

    Science.gov (United States)

    Bender, M. A.; Panofsky, H. A.; Peslen, C. A.

    1976-01-01

    In order to forecast clear-air turbulence (CAT) in jet aircraft flights, a study was conducted in which the data from a special-purpose instrument aboard a Boeing 747 jet airliner were compared with satellite-derived radiance gradients, conventional temperature gradients from analyzed maps, and temperature gradients obtained from a total air temperature sensor on the plane. The advantage of making use of satellite-derived data is that they are available worldwide without the need for radiosonde observations, which are scarce in many parts of the world. Major conclusions are that CAT probabilities are significantly higher over mountains than flat terrain, and that satellite radiance gradients appear to discriminate between CAT and no CAT better than conventional temperature gradients over flat lands, whereas the reverse is true over mountains, the differences between the two techniques being not large over mountains.

  15. What can be said can be said clearly

    International Nuclear Information System (INIS)

    The biggest problem in nuclear technology is not the technology itself but the public acceptance. Most people cannot evaluate the radiation risk themselves, so they must trust experts. But, laymen do not understand the jargon of radiation experts, whose language is full of technical terms, unfamiliar units, abbreviations and acronyms etc. After 26 years of experience in radiation protection and public information the author believes that the public has no possibility to leap over the broad communication gap. So, it is the experts who must do it. The author has discussed his communication strategy in his book The Core and the Apple Peel and implemented it in his book Radiation in Everyday Language. He stresses that nothing has been taught if nothing has been learned and claims that everything than can be said can be said clearly. (au)

  16. Endogenous Market-Clearing Prices and Reference Point Adaptation

    Science.gov (United States)

    Dragicevic, Arnaud Z.

    When prices depend on the submitted bids, i.e. with endogenous market-clearing prices in repeated-round auction mechanisms, the assumption of independent private values that underlines the property of incentive-compatibility is to be brought into question; even if these mechanisms provide active involvement and market learning. In its orthodox view, adaptive bidding behavior imperils incentive-compatibility. We relax the assumption of private values' independence in the repeated-round auctions, when the market-clearing prices are made public at the end of each round. Instead of using game-theory learning models, we introduce a behavioral model that shows that bidders bid according to the anchoring-and-adjustment heuristic, which neither ignores the rationality and incentive-compatibility constraints, nor rejects the posted prices issued from others' bids. Bidders simply weight information at their disposal and adjust their discovered value using reference points encoded in the sequential price weighting function. Our model says that bidders and offerers are sincere boundedly rational utility maximizers. It lies between evolutionary dynamics and adaptive heuristics and we model the concept of inertia as high weighting of the anchor, which stands for truthful bidding and high regard to freshly discovered preferences. Adjustment means adaptive rule based on adaptation of the reference point in the direction of the posted price. It helps a bidder to maximize her expected payoff, which is after all the only purpose that matters to rationality. The two components simply suggest that sincere bidders are boundedly rational. Furthermore, by deviating from their anchor in the direction of the public signal, bidders operate in a correlated equilibrium. The correlation between bids comes from the commonly observed history of play and each bidder's actions are determined by the history. Bidders are sincere if they have limited memory and confine their reference point adaptation

  17. Childhood to adolescence: dust and gas clearing in protoplanetary disks

    Science.gov (United States)

    Brown, Joanna Margaret

    Disks are ubiquitous around young stars. Over time, disks dissipate, revealing planets that formed hidden by their natal dust. Since direct detection of young planets at small orbital radii is currently impossible, other tracers of planet formation must be found. One sign of disk evolution, potentially linked to planet formation, is the opening of a gap or inner hole in the disk. In this thesis, I have identified and characterized several cold disks with large inner gaps but retaining massive primordial outer disks. While cold disks are not common, with ~5% of disks showing signs of inner gaps, they provide proof that at least some disks evolve from the inside-out. These large gaps are equivalent to dust clearing from inside the Earth's orbit to Neptune's orbit or even the inner Kuiper belt. Unlike more evolved systems like our own, the central star is often still accreting and a large outer disk remains. I identified four cold disks in Spitzer 5-40 μm spectra and modeled these disks using a 2-D radiative transfer code to determine the gap properties. Outer gap radii of 20-45 AU were derived. However, spectrophotometric identification is indirect and model-dependent. To validate this interpretation, I observed three disks with a submillimeter interferometer and obtained the first direct images of the central holes. The images agree well with the gap sizes derived from the spectrophotometry. One system, LkH&alpha 330, has a very steep outer gap edge which seems more consistent with gravitational perturbation rather than gradual processes, such as grain growth and settling. Roughly 70% of cold disks show CO v=1&rarr 0 gas emission from the inner 1 AU and therefore are unlikely to have evolved due to photoevaporation. The derived rotation temperatures are significantly lower for the cold disks than disks without gaps. Unresolved (sub)millimeter photometry shows that cold disks have steeper colors, indicating that they are optically thin at these wavelengths, unlike

  18. Clearing the way for reducing emissions from tropical deforestation

    International Nuclear Information System (INIS)

    Carbon emissions from tropical deforestation account for about 25% of all anthropogenic carbon dioxide emissions but cannot be credited under current climate change agreements. In the discussions around the architecture of the post-2012 climate regime, the possibility of including credits for reduced emissions from deforestation arises. The paper reviews two approaches for this, compensated reductions (CR) as proposed by Santilli et al. and the Joint Research Centre proposal that combine voluntary commitments by non-Annex I countries to reduce emissions from deforestation with carbon market financing. Both approaches have the clear advantages of simplicity and the possibility of fitting to an evolving greenhouse gas emission reduction regime. The authors consider the strengths and limitations of each proposal and build upon them to address several implementation challenges and options for improvement. Given the urgency of avoiding dangerous climate change, the timely development of technically sound, politically acceptable, cost-effective and practicable measures to reduce emissions from deforestation and forest degradation is essential. These two approaches take us a step closer to this goal, but they need to be refined rapidly to enable this goal to be realised

  19. Night sky luminance under clear sky conditions: Theory vs. experiment

    Science.gov (United States)

    Kocifaj, Miroslav

    2014-05-01

    Sky glow is caused by both natural phenomena and factors of anthropogenic origin, and of the latter ground-based light sources are the most important contributors for they emit the spatially linked spectral radiant intensity distribution of artificial light sources, which are further modulated by local atmospheric optics and perceived as the diffuse light of a night sky. In other words, sky glow is closely related to a city's shape and pattern of luminaire distribution, in practical effect an almost arbitrary deployment of random orientation of heterogeneous electrical light sources. Thus the luminance gradation function measured in a suburban zone or near the edges of a city is linked to the City Pattern or vice versa. It is shown that clear sky luminance/radiance data recorded in an urban area can be used to retrieve the bulk luminous/radiant intensity distribution if some a-priori information on atmospheric aerosols is available. For instance, the single scattering albedo of aerosol particles is required under low turbidity conditions, as demonstrated on a targeted experiment in the city of Frýdek-Mistek. One of the main advantages of the retrieval method presented in this paper is that the single scattering approximation is satisfactorily accurate in characterizing the light field near the ground because the dominant contribution to the sky glow has originated from beams propagated along short optical paths.

  20. Bridge Pressure Flow Scour at Clear Water Threshold Condition

    Institute of Scientific and Technical Information of China (English)

    GUO Junke; KERENYI Kornel; PAGAN-ORTIZ Jorge E; FLORA Kevin

    2009-01-01

    Bridge pressure flow scour at clear water threshold condition is studied theoretically and experimentally. The flume experiments reveal that the measured scour profiles under a bridge are more or less 2-dimensional; all the measured scour profiles can be described by two similarity equations, where the horizontal distance is scaled by the deck width while the local scour by the maximum scour depth; the maximum scour position is located just under the bridge about 15% deck width from the downstream deck edge; the scour begins at about one deck width upstream the bridge while the deposition occurs at about 2.5 deck widths downstream the bridge; and the maximum scour depth decreases with increas-ing sediment size, but increases with deck inundation. The theoretical analysis shows that: bridge scour can be divided into three cases, i.e. downstream unsubmerged, partially submerged, and totally submerged. For downstream unsubmerged flows, the maximum bridge scour depth is an open-channel problem where the conventional methods in terms of critical velocity or bed shear stress can be applied; for partially and totally submerged flows, the equilibrium maximum scour depth can be described by a scour and an inundation similarity number, which has been confirmed by experiments with two decks and two sediment sizes. For application, a design and field evaluation procedure with examples is presented, including the maximum scour depth and scour profile.

  1. Clearing the way for reducing emissions from tropical deforestation

    Energy Technology Data Exchange (ETDEWEB)

    Skutsch, M. [Department of Technology and Sustainable Development, University of Twente, P.O. Box 217, 7500 AE Enschede (Netherlands); Bird, N. [Joanneum Research, Elizabethstrasse 5/1, A-8010 Graz (Austria); Trines, E. [Gramserweg 2, 3711 AW Austerlitz (Netherlands); Dutschke, M. [Biocarbon, Badstrasse 41, 77652 Offenburg (Germany); Frumhoff, P. [Union of Concerned Scientists, 2 Brattle Square, Cambridge, MA 02238-9105 (United States); De Jong, B.H.J. [El Colegio de la Frontera Sur, Unidad Villahermosa, Carr. Vhsa-Reforma Km. 15.5, C.P. 86280, Ra Guineo 2da Secc, Villahermosa, Tabasco (Mexico); Van Laak, P. [ITC, Department of Natural Resources, P.O. Box 6, 7500 AA Enschede (Netherlands); Masera, O. [Centro de Investigaciones en Ecosistemas, UNAMAP 27-3 Xangari 58089, Morelia, Michoacan (Mexico); Murdiyarso, D. [Center for International Forestry Research, Jl. CIFOR, Situ Gede Sindangbarang, Bogor 16680 (Indonesia)

    2007-06-15

    Carbon emissions from tropical deforestation account for about 25% of all anthropogenic carbon dioxide emissions but cannot be credited under current climate change agreements. In the discussions around the architecture of the post-2012 climate regime, the possibility of including credits for reduced emissions from deforestation arises. The paper reviews two approaches for this, compensated reductions (CR) as proposed by Santilli et al. and the Joint Research Centre proposal that combine voluntary commitments by non-Annex I countries to reduce emissions from deforestation with carbon market financing. Both approaches have the clear advantages of simplicity and the possibility of fitting to an evolving greenhouse gas emission reduction regime. The authors consider the strengths and limitations of each proposal and build upon them to address several implementation challenges and options for improvement. Given the urgency of avoiding dangerous climate change, the timely development of technically sound, politically acceptable, cost-effective and practicable measures to reduce emissions from deforestation and forest degradation is essential. These two approaches take us a step closer to this goal, but they need to be refined rapidly to enable this goal to be realised.

  2. Clear antismudge unimolecular coatings of diblock copolymers on glass plates.

    Science.gov (United States)

    Macoretta, Danielle; Rabnawaz, Muhammad; Grozea, Claudia M; Liu, Guojun; Wang, Yu; Crumblehulme, Alison; Wyer, Martin

    2014-12-10

    Two poly[3-(triisopropyloxysilyl)propyl methacrylate]-block-poly[2-(perfluorooctyl)ethyl methacrylate] (PIPSMA-b-PFOEMA) samples and one poly(perfluoropropylene oxide)-block-poly-[3-(triisopropyloxysilyl)propyl methacrylate] (PFPO-b-PIPSMA) sample were synthesized, characterized, and used to coat glass plates. These coatings were formed by evaporating a dilute polymer solution containing HCl, which catalyzed PIPSMA's sol-gel chemistry. Polymer usage was minimized by targeting at diblock copolymer unimolecular (brush) layers that consisted of a sol-gelled grafted PIPSMA layer and an oil- and water-repellant fluorinated surface layer. Investigated is the effect of varying the catalyst amount, polymer amount, as well as block copolymer type and composition on the structure, morphology, and oil- and water-repellency of the coatings. Under optimized conditions, the prepared coatings were optically clear and resistant to writing by a permanent marker. The marker's trace was the faintest on PFPO-b-PIPSMA coatings. In addition, the PFPO-b-PIPSMA coatings were far more wear-resistant than the PIPSMA-b-PFOEMA coatings.

  3. Clear antismudge unimolecular coatings of diblock copolymers on glass plates.

    Science.gov (United States)

    Macoretta, Danielle; Rabnawaz, Muhammad; Grozea, Claudia M; Liu, Guojun; Wang, Yu; Crumblehulme, Alison; Wyer, Martin

    2014-12-10

    Two poly[3-(triisopropyloxysilyl)propyl methacrylate]-block-poly[2-(perfluorooctyl)ethyl methacrylate] (PIPSMA-b-PFOEMA) samples and one poly(perfluoropropylene oxide)-block-poly-[3-(triisopropyloxysilyl)propyl methacrylate] (PFPO-b-PIPSMA) sample were synthesized, characterized, and used to coat glass plates. These coatings were formed by evaporating a dilute polymer solution containing HCl, which catalyzed PIPSMA's sol-gel chemistry. Polymer usage was minimized by targeting at diblock copolymer unimolecular (brush) layers that consisted of a sol-gelled grafted PIPSMA layer and an oil- and water-repellant fluorinated surface layer. Investigated is the effect of varying the catalyst amount, polymer amount, as well as block copolymer type and composition on the structure, morphology, and oil- and water-repellency of the coatings. Under optimized conditions, the prepared coatings were optically clear and resistant to writing by a permanent marker. The marker's trace was the faintest on PFPO-b-PIPSMA coatings. In addition, the PFPO-b-PIPSMA coatings were far more wear-resistant than the PIPSMA-b-PFOEMA coatings. PMID:25399630

  4. Vaginal clear cell carcinoma in a Japanese Black cow.

    Science.gov (United States)

    Michishita, Masaki; Hori, Makito; Nakahira, Rei; Takahashi, Kimimasa

    2016-06-01

    During artificial insemination of an 18-year-old female Japanese Black cow, a mass that was of a hen's egg size was found in the vagina. On necropsy, the firm mass, measuring approximately 3.5 × 3.5 × 3.0 cm, was located at the superior region of the vagina. The cut surface of the mass was gray-white in color with occasional necrotic or hemorrhagic areas. Histologically, the mass was composed of tumor cells arranged in solid nests of various sizes with an occasional tubular structure separated by a delicate fibrovascular stroma. The tumor cells had a hypochromatic nucleus and abundant, faintly eosinophilic cytoplasm. The tumor cells contained diastase-sensitive periodic acid-Schiff positive granules. Immunohistochemically, tumor cells were positive for cytokeratin AE1/AE3, CAM5.2 and carcinoembryonic antigen, but not for vimentin, p63, estrogen receptor-α, progesterone receptor, α-smooth muscle actin, neuron-specific enolase, S-100 protein and chromogranin A. On the basis of these findings, the tumor was diagnosed as a clear cell carcinoma of the vagina. PMID:26852732

  5. ALDH2 protects against stroke by clearing 4-HNE

    Institute of Scientific and Technical Information of China (English)

    Jin-Min Guo; Ai-Jun Liu; Pu Zang; Wen-Zhe Dong; Li Ying; Wei Wang; Pu Xu

    2013-01-01

    Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme that metabolizes ethanol and toxic aldehydes such as 4-hydroxy-2-nonenal (4-HNE).Using an unbiased proteomic search,we identified ALDH2 deficiency in stroke-prone spontaneously hypertensive rats (SHR-SP) as compared with spontaneously hypertensive rats (SHR).We concluded the causative role of ALDH2 deficiency in neuronal injury as overexpression or activation of ALDH2conferred neuroprotection by clearing 4-HNE in in vitro studies.Further,ALDH2-knockdown rats revealed the absence of neuroprotective effects of PKCε.Moderate ethanol administration that is known to exert protection against stroke was shown to enhance the detoxification of 4-HNE,and to protect against ischemic cerebral injury through the PKCε-ALDH2 pathway.In SHR-SP,serum 4-HNE level was persistently elevated and correlated inversely with the lifespan.The role of 4-HNE in stroke in humans was also suggested by persistent elevation of its plasma levels for at least 6 months after stroke.Lastly,we observed that 21 of 1 242 subjects followed for 8 years who developed stroke had higher initial plasma 4-HNE levels than those who did not develop stroke.These findings suggest that activation of the ALDH2 pathway may serve as a useful index in the identification of stroke-prone subjects,and the ALDH2 pathway may be a potential target of therapeutic intervention in stroke.

  6. Hemosiderotic clear-cell acanthoma: A pigmented mimicker

    Directory of Open Access Journals (Sweden)

    Leonardo Bugatti

    2011-01-01

    Full Text Available The authors report on a case of a 65-year-old man with pigmented clear-cell acanthoma located on the right thigh. Dermoscopy disclosed a peculiar picture consisting of diffuse black pigmentation with a superficial greyish veil in the central portion, dotted-to-globular dark red-black structures mainly located at the periphery with a homogenous regular reticular arrangement; peripheral translucid desquamation. Dermoscopic features are correlated with the histology, where hemosiderin deposits present in a sheet-like arrangement in the perivascular papillary dermis and in a band-like disposition in the reticular dermis at the base of the lesion can account for the pigmented picture. The lesion arose on a trauma-prone skin site; thus the authors believe that traumatic irritation may be responsible for the clinical and dermoscopic pictures, giving rise to a reaction similar in a way to the Auspitz′s sign provocated by trauma for psoriasis. Red blood cells extravasation from extremely superficialized capillaries may have led to hemosiderin deposition in the papillary and the reticular dermis.

  7. A crystal-clear zebrafish for in vivo imaging.

    Science.gov (United States)

    Antinucci, Paride; Hindges, Robert

    2016-01-01

    The larval zebrafish (Danio rerio) is an excellent vertebrate model for in vivo imaging of biological phenomena at subcellular, cellular and systems levels. However, the optical accessibility of highly pigmented tissues, like the eyes, is limited even in this animal model. Typical strategies to improve the transparency of zebrafish larvae require the use of either highly toxic chemical compounds (e.g. 1-phenyl-2-thiourea, PTU) or pigmentation mutant strains (e.g. casper mutant). To date none of these strategies produce normally behaving larvae that are transparent in both the body and the eyes. Here we present crystal, an optically clear zebrafish mutant obtained by combining different viable mutations affecting skin pigmentation. Compared to the previously described combinatorial mutant casper, the crystal mutant lacks pigmentation also in the retinal pigment epithelium, therefore enabling optical access to the eyes. Unlike PTU-treated animals, crystal larvae are able to perform visually guided behaviours, such as the optomotor response, as efficiently as wild type larvae. To validate the in vivo application of crystal larvae, we performed whole-brain light-sheet imaging and two-photon calcium imaging of neural activity in the retina. In conclusion, this novel combinatorial pigmentation mutant represents an ideal vertebrate tool for completely unobstructed structural and functional in vivo investigations of biological processes, particularly when imaging tissues inside or between the eyes.

  8. DAФNE Operation with Electron-Cloud-Clearing Electrodes

    CERN Document Server

    Alesini, D; Gallo, A; Guiducci, S; Milardi, C; Stella, A; Zobov, Mikhail; De Santis, S; Demma, Theo; Raimondi, P

    2013-01-01

    The effects of an electron cloud (e-cloud) on beam dynamics are one of the major factors limiting performances of high intensity positron, proton, and ion storage rings. In the electron-positron collider DAΦNE, namely, a horizontal beam instability due to the electron-cloud effect has been identified as one of the main limitations on the maximum stored positron beam current and as a source of beam quality deterioration. During the last machine shutdown in order to mitigate such instability, special electrodes have been inserted in all dipole and wiggler magnets of the positron ring. It has been the first installation all over the world of this type since long metallic electrodes have been installed in all arcs of the collider positron ring and are currently used during the machine operation in collision. This has allowed a number of unprecedented measurements (e-cloud instabilities growth rate, transverse beam size variation, tune shifts along the bunch train) where the e-cloud contribution is clearly eviden...

  9. Genetic mutations associated with metastatic clear cell renal cell carcinoma

    Science.gov (United States)

    Wu, Qingjian; Li, Fengjie; Zhao, Jiang; Wu, Kaijin; Qu, Cunye; Chen, Yibu; Li, Meng; Chen, Xuelian; Stucky, Andres; Zhong, Jiangjian; Li, Longkun; Zhong, Jiang F.

    2016-01-01

    Metastasis is the major cause of death among cancer patients, yet early detection and intervention of metastasis could significantly improve their clinical outcomes. We have sequenced and analyzed RNA (Expression) and DNA (Mutations) from the primary tumor (PT), tumor extension (TE) and lymphatic metastatic (LM) sites of patients with clear cell renal cell carcinoma (CCRCC) before treatment. Here, we report a three-nucleotide deletion near the C-region of Plk5 that is specifically associated with the lymphatic metastasis. This mutation is un-detectable in the PT, becomes detectable in the TE and dominates the LM tissue. So while only a few primary cancer cells carry this mutation, the majority of metastatic cells have this mutation. The increasing frequency of this mutation in metastatic tissue suggests that this Plk5 deletion could be used as an early indicator of CCRCC metastasis, and be identified by low cost PCR assay. A large scale clinical trial could reveal whether a simple PCR assay for this mutation at the time of nephrectomy could identify and stratify high-risk CCRCC patients for treatments. PMID:26908440

  10. NOAA AVHRR Clear-Sky Products over Oceans (ACSPO): Sea Surface Temperature, Clear Sky Radiances, and Aerosol Optical Depth for the Global Ocean, 2011 - present (NCEI Accession 0072979)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The AVHRR Clear-Sky Processor over Oceans, jointly developed between NESDIS STAR and OSDPD, produces AVHRR clear-sky products over oceans. ACSPO generates output...

  11. Effect of mechanical optical clearing on near-infrared spectroscopy.

    Science.gov (United States)

    Idelson, Christopher R; Vogt, William C; King-Casas, Brooks; LaConte, Stephen M; Rylander, Christopher G

    2015-08-01

    Near-infrared Spectroscopy (NIRS) is a broadly utilized technology with many emerging applications including clinical diagnostics, sports medicine, and functional neuroimaging, to name a few. For functional brain imaging NIR light is delivered at multiple wavelengths through the scalp and skull to the brain to enable spatial oximetry measurements. Dynamic changes in brain oxygenation are highly correlated with neural stimulation, activation, and function. Unfortunately, NIRS is currently limited by its low spatial resolution, shallow penetration depth, and, perhaps most importantly, signal corruption due to light interactions with superficial non-target tissues such as scalp and skull. In response to these issues, we have combined the non-invasive and rapidly reversible method of mechanical tissue optical clearing (MOC) with a commercially available NIRS system. MOC utilizes a compressive loading force on tissue, causing the lateral displacement of blood and water, while simultaneously thinning the tissue. A MOC-NIRS Breath Hold Test displayed a ∼3.5-fold decrease in the time-averaged standard deviation between channels, consequentially promoting greater channel agreement. A Skin Pinch Test was implemented to negate brain and muscle activity from affecting the recorded signal. These results displayed a 2.5-3.0 fold increase in raw signal amplitude. Existing NIRS instrumentation has been further integrated within a custom helmet device to provide a uniform force distribution across the NIRS sensor array. These results showed a gradual decrease in time-averaged standard deviation among channels with an increase in applied pressure. Through these experiments, and the development of the MOC-NIRS helmet device, MOC appears to provide enhancement of NIRS technology beyond its current limitations. PMID:26041069

  12. MET Inhibition in Clear Cell Renal Cell Carcinoma

    Science.gov (United States)

    Xie, Zuoquan; Lee, Young H.; Boeke, Marta; Jilaveanu, Lucia B.; Liu, Zongzhi; Bottaro, Donald P.; Kluger, Harriet M.; Shuch, Brian

    2016-01-01

    Background: Clear cell renal cell carcinoma (ccRCC) is the most lethal form of kidney cancer. Small molecule VEGFR inhibitors are widely used but are not curative and various resistance mechanisms such as activation of the MET pathway have been described. Dual MET/VEGFR2 inhibitors have recently shown clinical benefit but limited preclinical data evaluates their effects in ccRCC. Methods: An interrogation of the Cancer Genome Atlas (TCGA) dataset was performed to evaluate oncogenic alterations in the MET/VEGFR2 pathway. We evaluated the in vitro effects of Cabozantinib, a dual MET/VEGFR2 inhibitor, using a panel of ccRCC cell lines. Drug effects of cell viability and proliferation, migration, cell scatter, anchorage independent growth, and downstream MET/VEGFR2 signaling pathways were assessed. Results: Twelve percent of TCGA cases had possible MET/HGF oncogenic alterations with co-occurrence noted (p<0.001). MET/HGF altered cases had worse overall survival (p=0.044). Cabozantinib was a potent inhibitor of MET and VEGFR2 in vitro in our cell line panel. PI3K, MAPK and mTOR pathways were also suppressed by cabozantinib, however the effects on cell viability in vitro were modest. At nanomolar concentrations of cabozantinib, HGF-stimulated migration, invasion, cellular scattering and soft agar colony formation were inhibited. Conclusions: We provide further preclinical rationale for dual MET/VEGFR2 inhibition in ccRCC. While the MET pathway is implicated in VEGFR resistance, dual inhibitors may have direct anti-tumor effects in a patient subset with evidence of MET pathway involvement. Cabozantinib is a potent dual MET/VEGFR2 inhibitor, significantly inhibits cell migration and invasion in vitro and likely has anti-angiogenic effects similar to other VEGFR tyrosine kinase inhibitors. Future work involving in vivo models will be useful to better define mechanisms of potential anti-tumor activity. PMID:27390595

  13. Gene expression profile of renal cell carcinoma clear cell type

    Directory of Open Access Journals (Sweden)

    Marcos F. Dall’Oglio

    2010-08-01

    Full Text Available PURPOSE: The determination of prognosis in patients with renal cell carcinoma (RCC is based, classically, on stage and histopathological aspects. The metastatic disease develops in one third of patients after surgery, even in localized tumors. There are few options for treating those patients, and even the new target designed drugs have shown low rates of success in controlling disease progression. Few studies used high throughput genomic analysis in renal cell carcinoma for determination of prognosis. This study is focused on the identification of gene expression signatures in tissues of low-risk, high-risk and metastatic RCC clear cell type (RCC-CCT. MATERIALS AND METHODS: We analyzed the expression of approximately 55,000 distinct transcripts using the Whole Genome microarray platform hybridized with RNA extracted from 19 patients submitted to surgery to treat RCC-CCT with different clinical outcomes. They were divided into three groups (1 low risk, characterized by pT1, Fuhrman grade 1 or 2, no microvascular invasion RCC; (2 high risk, pT2-3, Fuhrman grade 3 or 4 with, necrosis and microvascular invasion present and (3 metastatic RCC-CCT. Normal renal tissue was used as control. RESULTS: After comparison of differentially expressed genes among low-risk, high-risk and metastatic groups, we identified a group of common genes characterizing metastatic disease. Among them Interleukin-8 and Heat shock protein 70 were over-expressed in metastasis and validated by real-time polymerase chain reaction. CONCLUSION: These findings can be used as a starting point to generate molecular markers of RCC-CCT as well as a target for the development of innovative therapies.

  14. DISCRIMINATING BETWEEN CLOUDY, HAZY, AND CLEAR SKY EXOPLANETS USING REFRACTION

    Energy Technology Data Exchange (ETDEWEB)

    Misra, Amit K.; Meadows, Victoria S. [Astronomy Department, University of Washington, Seattle, WA 98195 (United States)

    2014-11-01

    We propose a method to distinguish between cloudy, hazy, and clear sky (free of clouds and hazes) exoplanet atmospheres that could be applicable to upcoming large aperture space- and ground-based telescopes such as the James Webb Space Telescope (JWST) and the European Extremely Large Telescope (E-ELT). These facilities will be powerful tools for characterizing transiting exoplanets, but only after a considerable amount of telescope time is devoted to a single planet. A technique that could provide a relatively rapid means of identifying haze-free targets (which may be more valuable targets for characterization) could potentially increase the science return for these telescopes. Our proposed method utilizes broadband observations of refracted light in the out-of-transit spectrum. Light refracted through an exoplanet atmosphere can lead to an increase of flux prior to ingress and subsequent to egress. Because this light is transmitted at pressures greater than those for typical cloud and haze layers, the detection of refracted light could indicate a cloud- or haze-free atmosphere. A detection of refracted light could be accomplished in <10 hr for Jovian exoplanets with JWST and <5 hr for super-Earths/mini-Neptunes with E-ELT. We find that this technique is most effective for planets with equilibrium temperatures between 200 and 500 K, which may include potentially habitable planets. A detection of refracted light for a potentially habitable planet would strongly suggest the planet was free of a global cloud or haze layer, and therefore a promising candidate for follow-up observations.

  15. Effect of mechanical optical clearing on near-infrared spectroscopy.

    Science.gov (United States)

    Idelson, Christopher R; Vogt, William C; King-Casas, Brooks; LaConte, Stephen M; Rylander, Christopher G

    2015-08-01

    Near-infrared Spectroscopy (NIRS) is a broadly utilized technology with many emerging applications including clinical diagnostics, sports medicine, and functional neuroimaging, to name a few. For functional brain imaging NIR light is delivered at multiple wavelengths through the scalp and skull to the brain to enable spatial oximetry measurements. Dynamic changes in brain oxygenation are highly correlated with neural stimulation, activation, and function. Unfortunately, NIRS is currently limited by its low spatial resolution, shallow penetration depth, and, perhaps most importantly, signal corruption due to light interactions with superficial non-target tissues such as scalp and skull. In response to these issues, we have combined the non-invasive and rapidly reversible method of mechanical tissue optical clearing (MOC) with a commercially available NIRS system. MOC utilizes a compressive loading force on tissue, causing the lateral displacement of blood and water, while simultaneously thinning the tissue. A MOC-NIRS Breath Hold Test displayed a ∼3.5-fold decrease in the time-averaged standard deviation between channels, consequentially promoting greater channel agreement. A Skin Pinch Test was implemented to negate brain and muscle activity from affecting the recorded signal. These results displayed a 2.5-3.0 fold increase in raw signal amplitude. Existing NIRS instrumentation has been further integrated within a custom helmet device to provide a uniform force distribution across the NIRS sensor array. These results showed a gradual decrease in time-averaged standard deviation among channels with an increase in applied pressure. Through these experiments, and the development of the MOC-NIRS helmet device, MOC appears to provide enhancement of NIRS technology beyond its current limitations.

  16. Clearing the Cosmic Fog - The Most Distant Galaxy Ever Measured

    Science.gov (United States)

    2010-10-01

    A European team of astronomers using ESO's Very Large Telescope (VLT) has measured the distance to the most remote galaxy so far. By carefully analysing the very faint glow of the galaxy they have found that they are seeing it when the Universe was only about 600 million years old (a redshift of 8.6). These are the first confirmed observations of a galaxy whose light is clearing the opaque hydrogen fog that filled the cosmos at this early time. The results were presented at an online press conference with the scientists on 19 October 2010, and will appear in the 21 October issue of the journal Nature. "Using the ESO Very Large Telescope we have confirmed that a galaxy spotted earlier using Hubble is the most remote object identified so far in the Universe" [1], says Matt Lehnert (Observatoire de Paris) who is lead author of the paper reporting the results. "The power of the VLT and its SINFONI spectrograph allows us to actually measure the distance to this very faint galaxy and we find that we are seeing it when the Universe was less than 600 million years old." Studying these first galaxies is extremely difficult. By the time that their initially brilliant light gets to Earth they appear very faint and small. Furthermore, this dim light falls mostly in the infrared part of the spectrum because its wavelength has been stretched by the expansion of the Universe - an effect known as redshift. To make matters worse, at this early time, less than a billion years after the Big Bang, the Universe was not fully transparent and much of it was filled with a hydrogen fog that absorbed the fierce ultraviolet light from young galaxies. The period when the fog was still being cleared by this ultraviolet light is known as the era of reionisation [2]. Despite these challenges the new Wide Field Camera 3 on the NASA/ESA Hubble Space Telescope discovered several robust candidate objects in 2009 [3] that were thought to be galaxies shining in the era of reionisation. Confirming the

  17. 'Towers in the Tempest' Computer Animation Submission

    Science.gov (United States)

    Shirah, Greg

    2008-01-01

    The following describes a computer animation that has been submitted to the ACM/SIGGRAPH 2008 computer graphics conference: 'Towers in the Tempest' clearly communicates recent scientific research into how hurricanes intensify. This intensification can be caused by a phenomenon called a 'hot tower.' For the first time, research meteorologists have run complex atmospheric simulations at a very fine temporal resolution of 3 minutes. Combining this simulation data with satellite observations enables detailed study of 'hot towers.' The science of 'hot towers' is described using: satellite observation data, conceptual illustrations, and a volumetric atmospheric simulation data. The movie starts by showing a 'hot tower' observed by NASA's Tropical Rainfall Measuring Mission (TRMM) spacecraft's three dimensional precipitation radar data of Hurricane Bonnie. Next, the dynamics of a hurricane and the formation of 'hot towers' are briefly explained using conceptual illustrations. Finally, volumetric cloud, wind, and vorticity data from a supercomputer simulation of Hurricane Bonnie are shown using volume techniques such as ray marching.

  18. Madeleine Leininger: claroscuro trascultural Madeleine Leininger: Clear and dark transcultural

    Directory of Open Access Journals (Sweden)

    David Fornons Fontdevila

    2010-09-01

    Full Text Available A principios de la década de los años 60, Madeleine Leininger conceptualiza y funda la Enfermería transcultural, pero a pesar de la vigencia y reconocimiento que actualmente posee la enfermería transcultural, ésta no se escapa de un territorio claro-oscuro de contradicciones y dicciones. ¿Qué concepto de cultura utiliza Madeleine Leininger? ¿Qué consecuencias implica su transculturalidad? En el artículo se debate la particularidad conceptual utilizada por Leininger. Así mismo se propone cambiar terminológicamente y conceptualmente significados y significantes como la etnoenfermería y los conceptos de transculturalidad que a ella refieren. Para evitar los determinismos culturales se considera más correcto hablar de las identidades culturales, propias e individuales. La enfermería debe establecer un diálogo transcultural con las identidades culturales, con las medicinas y enfermerías transculturales. Un diálogo en igualdad, no sin por ello renunciar a la riqueza y eficiencia de la enfermería y de la medicina occidentales.At the beginning of the decade of the 60s, Madeleine Leininger conceptualizes and founds the nursing transcultural, but in spite of the current force and recognition that nowadays possesses the nursing transcultural, this does not escape of a clear - dark territory of contradictions and dictions. What concept of culture does Madeleine Leininger use? What consequences does it imply her transculturality? In the article the conceptual particularity used by Leininger is debated. Likewise it proposes to change the term and conceptual important and significant as the etno-infirmary and the concepts of transcultural that recount her. To avoid the cultural determinisms it is more correct to speak about the cultural, own and individual identities. The nursing must establish a dialog transcultural with the cultural identities, with the medicines and transcultural nursing. A dialog in equality, not without for it to resign

  19. Theses E-Submission Tool at the National Technical University of Athens

    OpenAIRE

    Κουλούρης, Αλέξανδρος; Αναγνωστόπουλος, Άγγελος

    2010-01-01

    Purpose – This paper’s aim it to analyze added value that the theses e-submission system (tool) gave to the NTUA IR service. Design/methodology/approach – The paper describes the e-submission tool, its procedures and evaluates its use. Findings – The tool improved the IR service, which can be certified by the continuing evaluation process. This process produced the following main results: the automated batch importing feature should be integrated into the e-submission system;...

  20. Background submission to the Royal Commission on Nuclear Power Generation

    International Nuclear Information System (INIS)

    The Royal Commission on Nuclear Power Generation in New Zealand is required to inquire into and report upon the likely consequences of a nuclear power programme. The New Zealand Electricity Department would have prime responsibilty for implementing the construction, operation and maintenance of nuclear power plants should the need be established and should this be acceptable to the Government. In this submission the Department has attempted to present the issues raised by the introduction of nuclear power in relatively simple terms on the assumption that elaboration can be provided later if necessary

  1. NASA's Eos ClearingHOuse: Integrating Access to Data Services

    Science.gov (United States)

    Burnett, M. T.; Pfister, R.; Wichman, K.

    2002-12-01

    ECHO (The Earth Observing System (EOS) ClearingHOuse) is being developed to provide flexibility to NASA's EOS to better meet the needs of the science community. ECHO is a clearinghouse of metadata, representing the data offerings of participating data providers. ECHO is being built with the goal of being an enabling system: Enabling a variety of Data Providers to participate. Enabling access to an ever-changing variety of Earth Science Data. Enabling access to an ever-growing suite of services, provided by the Science Community, which improves the usefulness of this data, including the binding of those services to the data represented in the clearinghouse. The purpose of this enabling philosophy is to support current Science efforts, but also to give the opportunity for creative organizations and individuals to break the traditional paradigm for discovering and leveraging Earth Science Data and Services in completely new ways. This presentation will focus on ECHO's approach to integrating Data Services from varied Service Providers, and facilitating access to those services by the user community. ECHO can be viewed as a typical Service oriented architecture. The fundamental interactions that it supports are (abstractly) Publish, Find and Bind. ECHO provides interfaces and mechanisms that allow organizations to publish their services. Using these interfaces, Service Providers can effectively "plug-in" their capabilities. There are mechanisms that allow the correlation of their service to the data types in the clearinghouse. ECHO's user community can find, or discover, services through a separate set of interfaces. Bindings are the mechanisms that support the invocation of services by ECHO's user community. ECHO supports binding either directly between the user and the service provider, or indirectly by using ECHO as a Service Broker. ECHO is supporting all of these Service capabilities by leveraging the contemporary (and evolving) "standards" of Web Services. Web

  2. Extent and content of data for regulatory submissions: First-in-human and marketing authorization--Viewpoint of US industry.

    Science.gov (United States)

    Harris, Ian Ross

    2015-09-01

    The amount and type of data in regulatory submissions increases dramatically from the first-in-human clinical trials application through to the extensive dossier that is required for marketing authorization. The Pharmaceuticals and Biotechnology industries are very familiar with the requirements and expectations of Health Authorities for small molecule and biologics, but have limited experience for cell-based therapies. Fortunately, the United States Food and Drug Administration (FDA) and European Medicines agency (EMA) Committee for Advanced Therapies (CAT) have considerable experience in regulating cell therapies and have provided extensive Guidance documents for developers. The Agencies offers advice to Sponsors through a variety of meetings. However, it is incumbent on the Sponsor to understand the regulations, interpret the Guidance documents and formulate clear company positions to enable the Agency to provide clear feedback. It is important for Sponsors to understand the factors that are critical for the safety and efficacy of their product and to demonstrate to the Health Authorities that they have a control strategy that ensures safety and efficacy during all stages of development. The focus of this paper is to describe some of the challenges for the chemistry manufacturing and controls (CMC) for cell therapies being development internationally. PMID:26088904

  3. Evaluation of Clear Sky Models for Satellite-Based Irradiance Estimates

    Energy Technology Data Exchange (ETDEWEB)

    Sengupta, M.; Gotseff, P.

    2013-12-01

    This report describes an intercomparison of three popular broadband clear sky solar irradiance model results with measured data, as well as satellite-based model clear sky results compared to measured clear sky data. The authors conclude that one of the popular clear sky models (the Bird clear sky model developed by Richard Bird and Roland Hulstrom) could serve as a more accurate replacement for current satellite-model clear sky estimations. Additionally, the analysis of the model results with respect to model input parameters indicates that rather than climatological, annual, or monthly mean input data, higher-time-resolution input parameters improve the general clear sky model performance.

  4. 75 FR 11892 - Agency Information Collection Activities: Submission for OMB Review; Comment Request

    Science.gov (United States)

    2010-03-12

    ... HUMAN SERVICES Substance Abuse and Mental Health Services Administration Agency Information Collection Activities: Submission for OMB Review; Comment Request Periodically, the Substance Abuse and Mental Health.... Provide the following information about sample size calculation for the current FFY Synar survey....

  5. SDC Submission to the Environmental Audit Committee inquiry on : reducing carbon emissions from transport

    OpenAIRE

    Sustainable Development Commission

    2006-01-01

    In 2006 the Environmental Audit Committee launched an inquiry into how to reduce carbon emissions from transport. This is the Sustainable Development Commission's submission to the inquiry. Publisher PDF

  6. 75 FR 8389 - Agency Information Collection Activities: Submission for OMB Review; Comment Request, OMB No...

    Science.gov (United States)

    2010-02-24

    ... Investment Justification. SUMMARY: The Federal Emergency Management Agency (FEMA) has submitted the... SECURITY Federal Emergency Management Agency Agency Information Collection Activities: Submission for OMB... Communications Grant Program (IECGP) AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice;...

  7. 78 FR 60300 - Agency Information Collection Activities: Submission for OMB Review; Comment Request; FEMA's...

    Science.gov (United States)

    2013-10-01

    ... SECURITY Federal Emergency Management Agency Agency Information Collection Activities: Submission for OMB Review; Comment Request; FEMA's Grants Reporting Tool (GRT) AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: The Federal Emergency Management Agency (FEMA) will submit...

  8. 75 FR 38115 - Agency Information Collection Activities: Submission for OMB Review; Comment Request; FEMA Grants...

    Science.gov (United States)

    2010-07-01

    ... Federal Emergency Management Agency (FEMA) has submitted the information collection abstracted below to... SECURITY Federal Emergency Management Agency Agency Information Collection Activities: Submission for OMB... Emergency Management Agency, DHS. ACTION: Notice; 30-day notice and request for comments; revision of...

  9. 77 FR 21574 - Agency Information Collection Activities: Submission for OMB Review; Comment Request, FEMA...

    Science.gov (United States)

    2012-04-10

    ... SECURITY Federal Emergency Management Agency Agency Information Collection Activities: Submission for OMB...: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: The Federal Emergency Management Agency... addressed to the Desk Officer for the Department of Homeland Security, Federal Emergency Management...

  10. 75 FR 43995 - Agency Information Collection Activities: Submission for OMB Review; Comment Request, OMB No...

    Science.gov (United States)

    2010-07-27

    ...). SUMMARY: The Federal Emergency Management Agency (FEMA) will submit the information collection abstracted... SECURITY Federal Emergency Management Agency Agency Information Collection Activities: Submission for OMB... Sheet AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice; 30-day notice and request...

  11. 75 FR 38115 - Agency Information Collection Activities: Submission for OMB Review; Comment Request, OMB No...

    Science.gov (United States)

    2010-07-01

    ... Investment Justification Template. SUMMARY: The Federal Emergency Management Agency (FEMA) has submitted the... SECURITY Federal Emergency Management Agency Agency Information Collection Activities: Submission for OMB... (SHSP) Tribal AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice; 30-day notice...

  12. 75 FR 8387 - Agency Information Collection Activities: Submission for OMB Review; Comment Request, OMB No...

    Science.gov (United States)

    2010-02-24

    ... Emergency Management Agency (FEMA) has submitted the information collection abstracted below to the Office... SECURITY Federal Emergency Management Agency Agency Information Collection Activities: Submission for OMB... Program (DLSGP) AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice; 30-day notice...

  13. 76 FR 37824 - Agency Information Collection Activities: Submission for OMB Review; Comment Request, OMB No...

    Science.gov (United States)

    2011-06-28

    ...), NFA Long-Term Evaluation Supervisors. SUMMARY: The Federal Emergency Management Agency (FEMA) will... SECURITY Federal Emergency Management Agency Agency Information Collection Activities: Submission for OMB... Department of Homeland Security, Federal Emergency Management Agency, and sent via electronic mail to...

  14. 75 FR 8385 - Agency Information Collection Activities: Submission for OMB Review; Comment Request, OMB No...

    Science.gov (United States)

    2010-02-24

    .... SUMMARY: The Federal Emergency Management Agency (FEMA) has submitted the information collection... SECURITY Federal Emergency Management Agency Agency Information Collection Activities: Submission for OMB...) AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice; 30-day notice and request for...

  15. 78 FR 60299 - Agency Information Collection Activities: Submission for OMB Review; Comment Request; FEMA...

    Science.gov (United States)

    2013-10-01

    ... Management Agency, DHS. ACTION: Notice. SUMMARY: The Federal Emergency Management Agency (FEMA) will submit... SECURITY Federal Emergency Management Agency Agency Information Collection Activities: Submission for OMB... Department of Homeland Security, Federal Emergency Management Agency, and sent via electronic mail to...

  16. 75 FR 6213 - Agency Information Collection Activities: Submission for OMB Review; Comment Request, OMB No...

    Science.gov (United States)

    2010-02-08

    ... Calculation Worksheet. SUMMARY: The Federal Emergency Management Agency (FEMA) has submitted the information... SECURITY Federal Emergency Management Agency Agency Information Collection Activities: Submission for OMB... Homeland Security, Federal Emergency Management Agency, and sent via electronic mail to...

  17. 75 FR 32199 - Agency Information Collection Activities: Submission for OMB Review; Comment Request, OMB No...

    Science.gov (United States)

    2010-06-07

    ... Federal Emergency Management Agency (FEMA) has submitted the information collection abstracted below to... SECURITY Federal Emergency Management Agency Agency Information Collection Activities: Submission for OMB... Emergency Management Agency, DHS. ACTION: Notice; 30-day notice and request for comments; extension,...

  18. 75 FR 66115 - Agency Information Collection Activities: Submission for OMB Review; Comment Request; FEMA...

    Science.gov (United States)

    2010-10-27

    ... SECURITY Federal Emergency Management Agency Agency Information Collection Activities: Submission for OMB Review; Comment Request; FEMA Mitigation Success Story Database AGENCY: Federal Emergency Management.... SUMMARY: The Federal Emergency Management Agency (FEMA) has submitted the information...

  19. 75 FR 54287 - Submission of Electronic Documentation With Comailed and Copalletized Mailings

    Science.gov (United States)

    2010-09-07

    ... Register notice, Submission of Electronic Documentation with Comailed and Copalletized Mailings (75 FR... Part 111 Administrative practice and procedure, Postal Service. 0 Accordingly, 39 CFR Part 111 is... their origin, through the consolidation site, and ultimately into USPS processing. These...

  20. 76 FR 57745 - Agency Information Collection Activities: Submission for OMB Review; Comment Request

    Science.gov (United States)

    2011-09-16

    ... collection; Title of Information Collection: Medicare Advantage, Medicare Part D and Medicare Fee For Service... HUMAN SERVICES Centers for Medicare & Medicaid Services Agency Information Collection Activities: Submission for OMB Review; Comment Request AGENCY: Centers for Medicare & Medicaid Services, HHS....

  1. 78 FR 70057 - Agency Information Collection Activities: Submission for OMB Review; Comment Request

    Science.gov (United States)

    2013-11-22

    ... benefits to any Medicare Part D eligible individual must disclose whether their prescription drug benefit... HUMAN SERVICES Centers for Medicare & Medicaid Services Agency Information Collection Activities: Submission for OMB Review; Comment Request ACTION: Notice. SUMMARY: The Centers for Medicare &...

  2. 78 FR 67150 - Agency Information Collection Activities: Submission for OMB Review; Comment Request

    Science.gov (United States)

    2013-11-08

    ... insurers or payers, and pharmacies to coordinate prescription drug benefits provided to Medicare... HUMAN SERVICES Centers for Medicare & Medicaid Services [Document Identifiers: CMS-10171, CMS-10207, CMS...: Submission for OMB Review; Comment Request ACTION: Notice. SUMMARY: The Centers for Medicare &...

  3. 76 FR 13656 - Notice of Submission of Proposed Information Collection to OMB Requirement for Contractors to...

    Science.gov (United States)

    2011-03-14

    ... general liability, automobile liability insurance are in force before any construction work is started... forms of information technology, e.g., permitting electronic submission of responses. This notice also... certificates of insurance provide evidence that worker's compensation and general liability,...

  4. 77 FR 22797 - Submission of Proposed Information Collection to OMB: Certification of Consistency and Nexus...

    Science.gov (United States)

    2012-04-17

    ... URBAN DEVELOPMENT Submission of Proposed Information Collection to OMB: Certification of Consistency and Nexus Between Activities Proposed by the Applicant With Livability Principles Advanced in Preferred... applicant and the Livability Principles as they are being advanced in the Preferred Sustainability...

  5. 76 FR 71058 - Notice of Submission of Proposed Information Collection to OMB Loan Guarantee Recovery Fund...

    Science.gov (United States)

    2011-11-16

    ... URBAN DEVELOPMENT Notice of Submission of Proposed Information Collection to OMB Loan Guarantee Recovery... responses. This Notice Also Lists the Following Information Title of Proposal: Loan Guarantee Recovery Fund... Information Officer, HUD. ACTION: Notice. SUMMARY: The proposed information collection requirement...

  6. 78 FR 68095 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; American...

    Science.gov (United States)

    2013-11-13

    ... Information Collection Activities; Submission for OMB Review; Comment Request; American Recovery and... Training Administration (ETA) sponsored information collection request (ICR) titled, ``American Recovery... Information and Regulatory Affairs, Attn: OMB Desk Officer for DOL-ETA, Office of Management and Budget,...

  7. 78 FR 28007 - Submission for Review: Federal Employees' Group Life Insurance (FEGLI) Implementation...

    Science.gov (United States)

    2013-05-13

    ... From the Federal Register Online via the Government Publishing Office OFFICE OF PERSONNEL MANAGEMENT Submission for Review: Federal Employees' Group Life Insurance (FEGLI) Implementation Questionnaire for Tribal Employers AGENCY: U.S. Office of Personnel Management. ACTION: 60-Day Notice...

  8. 78 FR 33450 - Submission for Review: Report of Withholdings and Contributions for Health Benefits, Life...

    Science.gov (United States)

    2013-06-04

    ...) Report of Withholdings and Contributions for Health Benefits, Life Insurance and Retirement (Standard... MANAGEMENT Submission for Review: Report of Withholdings and Contributions for Health Benefits, Life Insurance and Retirement (Standard Form 2812); Report of Withholdings and Contributions for Health...

  9. 77 FR 59206 - Notice of Submission of Proposed Information Collection to OMB; OSHC Financial Reporting Form

    Science.gov (United States)

    2012-09-26

    ... Planning Grant Program, require the financial reporting by grantees. This tracking of grantee financial... URBAN DEVELOPMENT Notice of Submission of Proposed Information Collection to OMB; OSHC Financial... to HUD for a Sustainable Communities Initiative to improve regional planning efforts that...

  10. 76 FR 67470 - Notice of Submission of Proposed Information Collection to OMB; Energy Innovation Fund...

    Science.gov (United States)

    2011-11-01

    ... pilot program seeking innovative proposals for increasing the energy efficiency of Multifamily Housing... efficiency of Multifamily Housing. Frequency of Submission: Annually. Number of Annual Hours per respondents... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOUSING...

  11. 77 FR 19287 - Federal Acquisition Regulation; Submission for OMB Review; Progress Payments (SF-1443)

    Science.gov (United States)

    2012-03-30

    ... Register at 76 FR 81942, on December 29, 2011. No comments were received. Public comments are particularly... Regulation; Submission for OMB Review; Progress Payments (SF-1443) AGENCY: Department of Defense...

  12. 76 FR 37353 - Federal Acquisition Regulation; Submission for OMB Review; Contractor Business Ethics Compliance...

    Science.gov (United States)

    2011-06-27

    ... Regulation; Submission for OMB Review; Contractor Business Ethics Compliance Program and Disclosure... requirement concerning contractor business ethics compliance program and disclosure requirements. Public... Information Collection 9000- 0164, Contractor Business Ethics Compliance Program and Disclosure...

  13. 77 FR 65541 - Agency Information Collection Activities; Submission to the Office of Management and Budget for...

    Science.gov (United States)

    2012-10-29

    ..., Office of Management, publishes this notice containing proposed information collection requests at the... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF EDUCATION Agency Information Collection Activities; Submission to the Office of Management and Budget for...

  14. 76 FR 19106 - Agency Information Collection Activities: Submission for OMB Review; Comment Request

    Science.gov (United States)

    2011-04-06

    ... will be vital to increasing awareness and understanding of Medicaid mental health/substance abuse... HUMAN SERVICES Substance Abuse and Mental Health Services Administration Agency Information Collection Activities: Submission for OMB Review; Comment Request Periodically, the Substance Abuse and Mental...

  15. 75 FR 33631 - Science and Technology (S&T) Directorate; Agency Information Collection Activities: Submission...

    Science.gov (United States)

    2010-06-14

    ... SECURITY Science and Technology (S&T) Directorate; Agency Information Collection Activities: Submission for Review; Information Collection Request for the Department of Homeland Security (DHS) Science and... Security's (DHS's) Science and Technology (S&T) Directorate to provide information, resources...

  16. 75 FR 16491 - Science and Technology Directorate; Submission for Review; Information Collection Request for the...

    Science.gov (United States)

    2010-04-01

    ... SECURITY Science and Technology Directorate; Submission for Review; Information Collection Request for the Department of Homeland Security Science and Technology Directorate First Responders Community of Practice AGENCY: Science and Technology Directorate, DHS. ACTION: 30-day Notice and request for comment....

  17. 77 FR 66863 - Notice of Submission of Proposed Information Collection to OMB Electronic Stakeholder Survey...

    Science.gov (United States)

    2012-11-07

    ... URBAN DEVELOPMENT Notice of Submission of Proposed Information Collection to OMB Electronic Stakeholder... Stakeholder Survey is necessary to collect information for demonstrating the outputs and outcomes of meetings... lists the following information: Title of Proposed: Electronic Stakeholder Survey-Office...

  18. 75 FR 20400 - Submission for Review: Federal Cyber Service: Scholarship for Service (SFS) Registration Web Site

    Science.gov (United States)

    2010-04-19

    ... MANAGEMENT Submission for Review: Federal Cyber Service: Scholarship for Service (SFS) Registration Web Site... Science Foundation in accordance with the Federal Cyber Service Training and Education Initiative as...- enrolled students in Federal agencies. Analysis Agency: Federal Cyber Service: Scholarship For...

  19. 75 FR 45147 - Notice of Submission of Proposed Information Collection to OMB; Multifamily Project Construction...

    Science.gov (United States)

    2010-08-02

    ... lists the following information: Title of Proposal: Multifamily Project Construction Contract, Building... URBAN DEVELOPMENT Notice of Submission of Proposed Information Collection to OMB; Multifamily Project Construction Contract, Building Loan Agreement, & Construction Change; HUD Programs AGENCY: Office of the...

  20. 17 CFR 40.5 - Voluntary submission of rules for Commission review and approval.

    Science.gov (United States)

    2010-04-01

    ... proposed rule and any action taken or anticipated to be taken to adopt the proposed rule by the registered... proposed rule, the submission should include a reasoned analysis supporting the amendment to the...

  1. 75 FR 21603 - Information Collection; Submission for OMB Review, Comment Request

    Science.gov (United States)

    2010-04-26

    ... recruiting and managing community volunteers. The Corporation has entered into a cooperative agreement with... COMMUNITY SERVICE Information Collection; Submission for OMB Review, Comment Request AGENCY: Corporation for National and Community Service. ACTION: Notice. SUMMARY: The Corporation for National and Community...

  2. 78 FR 57162 - Agency Information Collection Activities: Submission for OMB Review; Comment Request

    Science.gov (United States)

    2013-09-17

    ... Collection: Medicare Advantage Program Requirements; Use: Medicare Advantage (MA) organizations and potential... HUMAN SERVICES Centers for Medicare & Medicaid Services Agency Information Collection Activities: Submission for OMB Review; Comment Request ACTION: Notice. SUMMARY: The Centers for Medicare &...

  3. 78 FR 78969 - Agency Information Collection Activities: Submission for OMB Review; Comment Request

    Science.gov (United States)

    2013-12-27

    ... control number); Title of Information Collection: Outpatient and Ambulatory Surgery Experience of Care... HUMAN SERVICES Centers for Medicare & Medicaid Services Agency Information Collection Activities: Submission for OMB Review; Comment Request ACTION: Notice. SUMMARY: The Centers for Medicare &...

  4. 75 FR 70279 - Notice of Submission of Proposed Information Collection to OMB; Allocation of Operating Subsidies...

    Science.gov (United States)

    2010-11-17

    ...: Allocation of Operating Subsidies under the Operating Fund. Formula: Data Collection. OMB Approval Number... URBAN DEVELOPMENT Notice of Submission of Proposed Information Collection to OMB; Allocation of Operating Subsidies under the Operating Fund Formula: Data Collection AGENCY: Office of the...

  5. 77 FR 57092 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

    Science.gov (United States)

    2012-09-17

    ... scientific evidence suggests that consumption of selenium may produce anticarcinogenic effects in the body... HUMAN SERVICES Food and Drug Administration Agency Information Collection Activities; Submission for...: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA)...

  6. 76 FR 59717 - Notice of Submission of Proposed Information Collection to OMB Transformation Initiative: Family...

    Science.gov (United States)

    2011-09-27

    ... URBAN DEVELOPMENT Notice of Submission of Proposed Information Collection to OMB Transformation... is approved by HUD's authority and administered under the Transformation Initiative Account. The... will be selected through a competitive process, announced through a Notice of Funding...

  7. 76 FR 59716 - Notice of Submission of Proposed Information Collection to OMB Transformation Initiative: Rent...

    Science.gov (United States)

    2011-09-27

    ... URBAN DEVELOPMENT Notice of Submission of Proposed Information Collection to OMB Transformation... HUD's authority and administered under the Transformation Initiative Account. The purpose of the... selected through a competitive process, announced through a Notice of Funding Availability...

  8. 77 FR 72351 - Agency Information Collection Activities: Submission for OMB Review; Comment Request

    Science.gov (United States)

    2012-12-05

    ... and Part D sponsoring organizations (Medicare Advantage Organizations , Cost Plans, and Medicare Part... HUMAN SERVICES Centers for Medicare & Medicaid Services Agency Information Collection Activities: Submission for OMB Review; Comment Request AGENCY: Centers for Medicare & Medicaid Services, HHS....

  9. 78 FR 42983 - Submission for Renewal: Information Collection; Questionnaire for National Security Positions...

    Science.gov (United States)

    2013-07-18

    ... MANAGEMENT Submission for Renewal: Information Collection; Questionnaire for National Security Positions... request (ICR), Office of Management and Budget (OMB) Control No. 3206-0005, for Questionnaire for National... the revised information collection of information, Questionnaire for National Security Positions,...

  10. 76 FR 65742 - Notice of Submission of Proposed Information Collection to OMB; Limited English Proficiency...

    Science.gov (United States)

    2011-10-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT Notice of Submission of Proposed Information Collection to OMB; Limited English... transmission of data. Title of Proposal: Limited English Proficiency Initiative Program Reporting. OMB...

  11. 76 FR 81958 - Notice of Submission of Proposed Information Collection to OMB; Limited English Proficiency...

    Science.gov (United States)

    2011-12-29

    ... URBAN DEVELOPMENT Notice of Submission of Proposed Information Collection to OMB; Limited English... translated materials and other programs that support the assistance of persons with limited English... Following Information Title of Proposal: Limited English Proficiency Initiative (LEPI) Program. OMB...

  12. 76 FR 77020 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Coke Oven...

    Science.gov (United States)

    2011-12-09

    ... Information Collection Activities; Submission for OMB Review; Comment Request; Coke Oven Emissions ACTION... Administration (OSHA) sponsored information collection request (ICR) titled, ``Coke Oven Emissions,'' to the...: The purpose of Coke Oven Emissions Standard and its information collection requirements, codified...

  13. 48 CFR 752.7005 - Submission requirements for development experience documents.

    Science.gov (United States)

    2010-10-01

    ... E540.5.2b(3). Information may be obtained from the Cognizant Technical Officer (CTO). These reports... submission is made to the CTO. (ii) The contractor shall submit the reports index referenced in paragraph...

  14. 75 FR 41207 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

    Science.gov (United States)

    2010-07-15

    ... collection requirements. Part 105 contains special labeling requirements for hypoallergenic foods, infant... HUMAN SERVICES Food and Drug Administration Agency Information Collection Activities; Submission for Office of Management and Budget Review; Comment Request; Food Labeling Regulations AGENCY: Food and...

  15. 78 FR 5451 - Federal Acquisition Regulation; Submission for OMB Review; Permits, Authorities, or Franchises

    Science.gov (United States)

    2013-01-25

    ... contractor, at its expense, to obtain and maintain any permits, franchises, licenses, and other authorities... Regulation; Submission for OMB Review; Permits, Authorities, or Franchises AGENCIES: Department of Defense... previously approved information collection requirement concerning permits, authorities, or franchises...

  16. 77 FR 6814 - Agency Information Collection Activities: Bonded Warehouse Proprietor's Submission

    Science.gov (United States)

    2012-02-09

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Bonded Warehouse... the Bonded Warehouse Proprietor's Submission (CBP Form 300). This request for comment is being made... CBP is soliciting comments concerning the following information collection: Title: Bonded...

  17. 76 FR 64368 - Notice of Submission of Proposed Information Collection to OMB Homelessness Prevention Study

    Science.gov (United States)

    2011-10-18

    ... URBAN DEVELOPMENT Notice of Submission of Proposed Information Collection to OMB Homelessness Prevention... site visits that are part of HUD's Homelessness Prevention Study. The proposed information collection... collection for the Homelessness Prevention study that was already approved under emergency review...

  18. 78 FR 42091 - Agency Information Collection Activities: Submission for Office of Management and Budget (OMB...

    Science.gov (United States)

    2013-07-15

    ... HHS Mandatory Guidelines for Federal Workplace Drug Testing Programs (73 FR 71858) dated November 25..., incomplete submission of the information, refusal to provide a specimen, or substitution or adulteration of...

  19. 78 FR 55727 - Draft Guidance for Industry on Recommendations for Preparation and Submission of Animal Food...

    Science.gov (United States)

    2013-09-11

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Recommendations for Preparation and Submission of Animal Food Additive Petitions; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing...

  20. Effect of clear-cutting silviculture on soil respiration in a subtropical forest of China

    OpenAIRE

    Ma, Yinlei; Geng, Yan; Huang, Yuanyuan; Shi, Yue; Niklaus, Pascal A.; Schmid, Bernhard; He, Jin-Sheng

    2013-01-01

    Aims: Clear-cutting is a common forest management practice, especially in subtropical China. However, the potential ecological consequences of clear-cutting remain unclear. In particular, the effect of clear-cutting on soil processes, such as the carbon cycle, has not been quantified in subtropical forests. Here, we investigated the response of soil respiration (Rs) to clear-cutting during a 12-month period in a subtropical forest in eastern China. Methods: We randomly selected four clear-...

  1. The Research on Submissive Behaviour of Students in the Second Level of Elementary School

    OpenAIRE

    ATLİ, Abdullah; KAYA, Alim; Zerrin Bölükbaşı MACİT

    2010-01-01

    This study examined the submissive behaviors of second level of elementary school students at with respect to some variables Participants were 430 students 172 42 6 girls and 231 57 4 boys Among these participants 156 38 6 were 6th graders 104 26 were 7th graders and 143 35 4 were 8th graders The data were collected using Student Personal Information Form developed by researchers and Submissive Behaviors Scale The data collected were analyzed using t test One way AN...

  2. The Relation Between Submissive Behaviours and Self Esteem State Among Nursing Students

    OpenAIRE

    Ilkay Arslan Ozkan; Ayse Ozen

    2008-01-01

    BACKGROUND: The aim of this study is to determine relationship between submissive acts and self esteem among nursing students. METHODS: This descriptive research has been performed with 322 nursing students in Akdeniz University, between February 2007-March 2007. Research data has derived by the questionnaire from that composed of two-parts. In the first part The Submissive Act Scale (SAS) and in the second part The Coopersmith Esteem Inventory (CSEI) has been used. The data analyzed by spea...

  3. CLEAR Landscape Change Module: No Increased Restoration and Protection, UTM Zone 15N NAD83, Coastal Louisiana Ecosystem Assessment and Restoration (2007), [CLEAR_Output_NIA_012307_final

    Data.gov (United States)

    Louisiana Geographic Information Center — The Coastal Louisiana Ecosystem Assessment and Restoration (CLEAR) Framework is an integrated ecosystem forecasting system, designed to simulate ecological change...

  4. Pediatric evaluation of the ClearVoice™ speech enhancement algorithm in everyday life

    Directory of Open Access Journals (Sweden)

    Nathalie Noël-Petroff

    2013-12-01

    Full Text Available ClearVoice™ enables Advanced Bionics cochlear implant users to improve their speech understanding in difficult listening environments, without compromising performance in quiet situations. The aim of the study was to evaluate the benefits of ClearVoice in children. Children between six and fourteen years of age randomly tested two modalities of ClearVoice for one month each. The baseline program, HiRes 120™, and both ClearVoice programs were evaluated with a sentence test in quiet and noise. Parents and teachers completed a questionnaire related to everyday noisy situations. The switchover to ClearVoice was uneventful for both modalities. Adjustments to thresholds and comfort levels were required. Seven out of the nine children preferred a ClearVoice program. No impact of ClearVoice on performance in quiet was observed and both modalities of ClearVoice improved speech understanding in noise compared to the baseline program, significantly with ClearVoice high. Positive outcomes were obtained from the questionnaires and discussions with parents and children. This study showed that children benefited from using ClearVoice in their daily life. There was a clear trend towards improved speech understanding in noise with ClearVoice, without affecting performance in quiet; therefore ClearVoice can be used by children all day, without having to change programs.

  5. 76 FR 16588 - Risk Management Requirements for Derivatives Clearing Organizations; Correction

    Science.gov (United States)

    2011-03-24

    ... From the Federal Register Online via the Government Publishing Office COMMODITY FUTURES TRADING COMMISSION 17 CFR Part 39 RIN 3038-AC98 Risk Management Requirements for Derivatives Clearing Organizations..., regarding Risk Management Requirements for Derivatives Clearing Organizations. FOR FURTHER...

  6. 75 FR 81264 - Critical Path Transmission, LLC; Clear Power, LLC; v. California Independent System Operator, Inc...

    Science.gov (United States)

    2010-12-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Critical Path Transmission, LLC; Clear Power, LLC; v. California Independent... (2006), Critical Path Transmission, LLC and Clear Power LLC (Complainants) filed a complaint...

  7. Clear cell variant of calcifying epithelial odontogenic tumor of maxilla: Report of a rare case.

    Science.gov (United States)

    Badrashetty, Dinesh; Rangaswamy, Shruthi; Belgode, Niranjan

    2013-09-01

    The calcifying epithelial odontogenic tumor (CEOT) is a rare benign tumor of the jaws. Pindborg's tumor having clear cells is extremely rare. Twelve central lesions have been reported of which only three cases have occurred in maxilla. Clear cell variant is a distinct entity, has more aggressive biological behavior and higher chances of recurrence. Hence it is important that presence of clear cells be included in histopathological diagnosis. Here we present a rare case of clear cell CEOT having aggressive behavior.

  8. Light-sheet microscopy imaging of a whole cleared rat brain with Thy1-GFP transgene

    OpenAIRE

    Marzena Stefaniuk; Gualda, Emilio J.; Monika Pawlowska; Diana Legutko; Paweł Matryba; Paulina Koza; Witold Konopka; Dorota Owczarek; Marcin Wawrzyniak; Pablo Loza-Alvarez; Leszek Kaczmarek

    2016-01-01

    Whole-brain imaging with light-sheet fluorescence microscopy and optically cleared tissue is a new, rapidly developing research field. Whereas successful attempts to clear and image mouse brain have been reported, a similar result for rats has proven difficult to achieve. Herein, we report on creating novel transgenic rat harboring fluorescent reporter GFP under control of neuronal gene promoter. We then present data on clearing the rat brain, showing that FluoClearBABB was found superior ove...

  9. Perception of foreign-accented clear speech by younger and older English listeners

    OpenAIRE

    Li, Chi-Nin

    2009-01-01

    Naturally produced English clear speech has been shown to be more intelligible than English conversational speech. However, little is known about the extent of the clear speech effects in the production of nonnative English, and perception of foreign-accented English by younger and older listeners. The present study examined whether Cantonese speakers would employ the same strategies as those used by native English speakers in producing clear speech in their second language. Also, the clear s...

  10. An acoustic-phonetic comparison of the clear speaking styles of late Finnish-English bilinguals

    OpenAIRE

    Granlund, S.; Hazan, V.; Baker, R.

    2012-01-01

    Research on clear speech, an intelligibility-enhancing speaking style, has proposed that global clear speech modifications which make speech more perceptible in adverse conditions are language-independent, while the more fine-grained segmental clear speech modifications, which enhance the salience of phonological contrasts, are language-specific [Bradlow, A.R. & Bent, T., 2002. The clear speech effect for non-native listeners. Journal of the Acoustical Society of America, 112, 272–284]. This ...

  11. 21 CFR 866.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... marketed device in that generic type of device; e.g., a surgical instrument cuts tissue with a laser beam... (AIDS), chronic or active hepatitis, tuberculosis, or myocardial infarction or to monitor therapy;...

  12. 21 CFR 876.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... marketed device in that generic type of device; e.g., a surgical instrument cuts tissue with a laser beam... (AIDS), chronic or active hepatitis, tuberculosis, or myocardial infarction or to monitor therapy;...

  13. 21 CFR 892.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... that generic type of device; e.g., a surgical instrument cuts tissue with a laser beam rather than with... hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4) For assessing the risk...

  14. 21 CFR 868.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... that generic type of device; e.g., a surgical instrument cuts tissue with a laser beam rather than with... hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4) For assessing the risk...

  15. 21 CFR 890.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... that generic type of device; e.g., a surgical instrument cuts tissue with a laser beam rather than with... hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4) For assessing the risk...

  16. 21 CFR 864.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... marketed device in that generic type of device; e.g., a surgical instrument cuts tissue with a laser beam... (AIDS), chronic or active hepatitis, tuberculosis, or myocardial infarction or to monitor therapy;...

  17. 21 CFR 886.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... that generic type of device; e.g., a surgical instrument cuts tissue with a laser beam rather than with... hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4) For assessing the risk...

  18. 21 CFR 872.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... that generic type of device; e.g., a surgical instrument cuts tissue with a laser beam rather than with... hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4) For assessing the risk...

  19. 21 CFR 870.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... that generic type of device; e.g., a surgical instrument cuts tissue with a laser beam rather than with... hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4) For assessing the risk...

  20. 21 CFR 862.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... laser beam rather than with a sharpened metal blade, or an in vitro diagnostic device detects or... therapy; (4) For assessing the risk of cardiovascular diseases; (5) For use in diabetes management;...

  1. 21 CFR 882.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... that generic type of device; e.g., a surgical instrument cuts tissue with a laser beam rather than with... hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4) For assessing the risk...

  2. 21 CFR 878.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... marketed device in that generic type of device; e.g., a surgical instrument cuts tissue with a laser beam... (AIDS), chronic or active hepatitis, tuberculosis, or myocardial infarction or to monitor therapy;...

  3. 21 CFR 888.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... that generic type of device; e.g., a surgical instrument cuts tissue with a laser beam rather than with... hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4) For assessing the risk...

  4. 21 CFR 874.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    Science.gov (United States)

    2010-04-01

    ... that generic type of device; e.g., a surgical instrument cuts tissue with a laser beam rather than with... hepatitis, tuberculosis, or myocardial infarction or to monitor therapy; (4) For assessing the risk...

  5. Clear & Simple

    Science.gov (United States)

    ... thrill seeking behavior, views toward or participation in violence) Related knowledge, attitudes, and practices (e.g., stigma, shame, discrimination) Patterns of use of related services (urban vs. rural, access to services, travel distance and ...

  6. Physics and medicine: ICTR-PHE 2016 opens abstract submission

    CERN Multimedia

    2015-01-01

    The third edition of the joint ICTR (International Conference on Transnational Research in Radiation Oncology) and PHE (Physics for Health in Europe) conference (see here) will take place from 15 to 19 February 2016 at the Geneva International Conference Centre (CICG). This biennial event, co-organised by CERN, has become a staple amongst the scientific communities involved in multidisciplinary research at the crossing of physics, medicine, and biology.   Abstract submission and registration are now open: detector physicists, radiochemists, nuclear-medicine physicians and physicists, biologists, software developers, accelerator experts, and oncologists are encouraged to “think outside the box” and make innovative proposals. Last year’s programme shows the breadth and diversity of subjects, which makes this conference a unique place to showcase your research, see how the same topic is approached by different disciplines, engage in stimulating discussions, ...

  7. Physics and medicine: ICTR-PHE 2016 opens abstract submission

    CERN Multimedia

    2015-01-01

    The third edition of the joint ICTR (International Conference on Transnational Research in Radiation Oncology) and PHE (Physics for Health in Europe) conference (see here) will take place from 15 to 19 February 2016 at the Geneva International Conference Centre (CICG). This biennial event, co-organised by CERN, has become a staple amongst the scientific communities involved in multidisciplinary research at the crossing of physics, medicine, and biology.   Abstract submission and registration are now open: detector physicists, radiochemists, nuclear-medicine physicians and physicists, biologists, software developers, accelerator experts, and oncologists are encouraged to “think outside the box” and make innovative proposals. Last year’s programme shows the breadth and diversity of subjects, which makes this conference a unique place to showcase your research, see how the same topic is approached by different disciplines, engage in stimulating discussions,...

  8. Clear-cell variant of calcifying epithelial odontogenic tumor (Pindborg tumor) in the mandible

    Institute of Scientific and Technical Information of China (English)

    Ching-Yi Chen; Chung-Wei Wu; Wen-Chen Wang; Li-Min Lin; Yuk-Kwan Chen

    2013-01-01

    We present an uncommon case (female patient aged 59 years) of the clear-cell variant of calcifying epithelial odontogenic tumor (CEOT) (also known as Pindborg tumor) in the mandible. The clinical characteristics and probable origins of the clear tumor cells of previously reported cases of clear-cell variant of intraosseous CEOT are also summarized and discussed.

  9. 78 FR 3960 - Self-Regulatory Organizations; National Securities Clearing Corporation; Notice of Filing of...

    Science.gov (United States)

    2013-01-17

    ..., insurance companies, hedge funds, bank trust departments, and pension funds), the investment manager (who... Settle at The Depository Trust Company for the Purpose of Calculating Its Clearing Fund Under Procedure... (``DTC'') for the purpose of calculating the NSCC clearing fund (``Clearing Fund'') under Procedure XV...

  10. 78 FR 61436 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing and Immediate...

    Science.gov (United States)

    2013-10-03

    ... to the Definition of Hedge Clearing Member September 27, 2013. Pursuant to Section 19(b)(1) of the... to the definition of Hedge Clearing Member. II. Clearing Agency's Statement of the Purpose of, and... the proposed rule change. The text of these statements may be examined at the places specified in...

  11. Talker Differences in Clear and Conversational Speech: Vowel Intelligibility for Older Adults with Hearing Loss

    Science.gov (United States)

    Ferguson, Sarah Hargus

    2012-01-01

    Purpose: To establish the range of talker variability for vowel intelligibility in clear versus conversational speech for older adults with hearing loss and to determine whether talkers who produced a clear speech benefit for young listeners with normal hearing also did so for older adults with hearing loss. Method: Clear and conversational vowels…

  12. 46 CFR 308.551 - War risk insurance clearing agency agreement for cargo, Form MA-321.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false War risk insurance clearing agency agreement for cargo, Form MA-321. 308.551 Section 308.551 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... clearing agency agreement for cargo, Form MA-321. The standard form of clearing agency agreement, Form...

  13. 76 FR 31518 - Public Roundtable on the Protection of Cleared Swaps Customer Collateral

    Science.gov (United States)

    2011-06-01

    ... COMMISSION 17 CFR Parts 22 and 190 Public Roundtable on the Protection of Cleared Swaps Customer Collateral... related to the protection of cleared swaps customer collateral described in the CFTC's notice of proposed rulemaking regarding the Protection of Cleared Swaps Customer Contracts and Collateral and...

  14. Clear cell variant of intraosseous mucoepidermoid carcinoma: Report of a rare entity

    Directory of Open Access Journals (Sweden)

    Sujatha Varma

    2012-01-01

    Full Text Available Intraosseous mucoepidermoid carcinoma of jaw bones is a rare lesion. Abundance of clear cells in an intraosseous mucoepidermoid carcinoma may complicate its histopathologic diagnosis. It becomes extremely important to distinguish this lesion from other clear cell lesions of jaw region. Here, we report a case of clear cell variant of intraosseous mucoepidermoid carcinoma in the mandible.

  15. 45 CFR 5.67 - Exemption six: Clearly unwarranted invasion of personal privacy.

    Science.gov (United States)

    2010-10-01

    ...: Clearly unwarranted invasion of personal privacy. (a) Documents affected. We may withhold records about individuals if disclosure would constitute a clearly unwarranted invasion of their personal privacy. (b... 45 Public Welfare 1 2010-10-01 2010-10-01 false Exemption six: Clearly unwarranted invasion...

  16. GSE moves to a new system of submission

    Directory of Open Access Journals (Sweden)

    2006-01-01

    Full Text Available Abstract Since October 10, 2005 the management of manuscripts submitted to GSE has moved to a new electronic system: Management Manuscript System or MMS. This system offers different services, which facilitate submission of manuscripts and contribute to their efficient and rapid processing. It is accessible at: http://www.edpsciences.org/gse. With this system, we expect to process your manuscripts quickly and efficiently. In the editorial board, two new scientific editors: Hélène Hayes (INRA, Jouy-en-Josas, France and Philippe Baret (Université catholique de Louvain, Belgium have taken over from Francis Minvielle, after six years of active and successful participation as Scientific Editor. H. Hayes will address manuscripts in molecular biology, while P. Baret will deal with those in quantitative genetics. Didier Boichard (INRA, Jouy-en-Josas, France will act as Editor-in-Chief. The journal thanks Michel Georges for his continuous help, as former Editor-in-Chief, to improve the quality and the international audience of GSE. For the fourth consecutive year, the impact factor of GSE is in progression (1.65 in 2004. Most of the articles published in GSE have focused on original research in quantitative and molecular genetics of farm and experimental animals, as well as related species. Since the number of submissions has markedly increased over the last two years, GSE has slightly modified its scope by restricting it to domesticated and experimental species and leaving articles on wild species to more specialised journals. The expected outcome is that GSE will specialize on papers with a strong methodological dimension to help understand, maintain and exploit animal genetic variability.

  17. 21 CFR 1316.57 - Submission of documentary evidence and affidavits and identification of witnesses subsequent to...

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Submission of documentary evidence and affidavits... PROCEDURES Administrative Hearings § 1316.57 Submission of documentary evidence and affidavits and identification of witnesses subsequent to prehearing conference. All documentary evidence and affidavits...

  18. Spatiotemporal analysis of the Porcine Reproductive and Respiratory Syndrome (PRRS) epidemic in Denmark using laboratory submission data

    DEFF Research Database (Denmark)

    Lopes Antunes, Ana Carolina; Toft, Nils; Hisham Beshara Halasa, Tariq

    spatiotemporal analysis of serological tests. Records of PRRS serology submissions made from January 2007 to December 2010 stored in the DIANOVA Information Management System at the National Veterinary Institute (DTU Vet) were used in the analysis. Each submission consists in individual blood samples collected...

  19. 17 CFR 240.17a-25 - Electronic submission of securities transaction information by exchange members, brokers, and...

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Electronic submission of... Preservation of Records and Reports of Certain Stabilizing Activities § 240.17a-25 Electronic submission of... transaction information for transactions involving entities that trade using multiple accounts: (1)(i) If...

  20. 78 FR 73553 - Prospective Grant of Exclusive License: Development of Cripto-1 Point of Care (POC) Tests and...

    Science.gov (United States)

    2013-12-06

    ... 510K cleared Point of Care (POC) tests and kits for the purpose of disease state recognition, detection..., pancreas, stomach, gallbladder, breast, lung, endometrium and cervix. Current methodologies of...

  1. 77 FR 76109 - Self-Regulatory Organizations; ICE Clear Credit LLC; Notice of Filing of Proposed Rule Change to...

    Science.gov (United States)

    2012-12-26

    ... Clearing Participant affiliates). In a default scenario, if the defaulting Clearing Participant has funded... contributing Clearing Participants would be used immediately following the defaulting Clearing Participant's... Contracts, specifically the ICC Treasury Operations Policies & Procedures, ICC Risk Management Framework...

  2. The Relation Between Submissive Behaviours and Self Esteem State Among Nursing Students

    Directory of Open Access Journals (Sweden)

    Ilkay Arslan Ozkan

    2008-02-01

    Full Text Available BACKGROUND: The aim of this study is to determine relationship between submissive acts and self esteem among nursing students. METHODS: This descriptive research has been performed with 322 nursing students in Akdeniz University, between February 2007-March 2007. Research data has derived by the questionnaire from that composed of two-parts. In the first part The Submissive Act Scale (SAS and in the second part The Coopersmith Esteem Inventory (CSEI has been used. The data analyzed by spearman’s correlation analysis. RESULTS: According to collected data; the students, who has participated to research 34.88 +-8.7 SAS average and 74.78 +/- 16.2 CSEI average has been established. 47 % of the students have SAS points more than average and 65 % of the students have high self esteem level is confirmed. As a result correlation analysis, significant relationship has determined between submissive acts and self esteem (r=- 0.42, p<0.01. According to the findings; submissive acts were negatively correlated with self esteem. CONCLUSION: Communications and interpersonal relationships are very important for nursing. Nurses play a vital communication role in the healthcare system. Assertiveness and self esteem is necessary for effective nurse communication. Because of the process of becoming a nurse is started at nursing school, nursing education should be more promote to self esteem and decreased to submissive behaviours through educational methods. [TAF Prev Med Bull. 2008; 7(1: 53-58

  3. The Relation Between Submissive Behaviours and Self Esteem State Among Nursing Students

    Directory of Open Access Journals (Sweden)

    Ilkay Arslan Ozkan

    2008-02-01

    Full Text Available BACKGROUND: The aim of this study is to determine relationship between submissive acts and self esteem among nursing students. METHODS: This descriptive research has been performed with 322 nursing students in Akdeniz University, between February 2007-March 2007. Research data has derived by the questionnaire from that composed of two-parts. In the first part The Submissive Act Scale (SAS and in the second part The Coopersmith Esteem Inventory (CSEI has been used. The data analyzed by spearman’s correlation analysis. RESULTS: According to collected data; the students, who has participated to research 34.88 +-8.7 SAS average and 74.78 +/- 16.2 CSEI average has been established. 47 % of the students have SAS points more than average and 65 % of the students have high self esteem level is confirmed. As a result correlation analysis, significant relationship has determined between submissive acts and self esteem (r=- 0.42, p<0.01. According to the findings; submissive acts were negatively correlated with self esteem. CONCLUSION: Communications and interpersonal relationships are very important for nursing. Nurses play a vital communication role in the healthcare system. Assertiveness and self esteem is necessary for effective nurse communication. Because of the process of becoming a nurse is started at nursing school, nursing education should be more promote to self esteem and decreased to submissive behaviours through educational methods. [TAF Prev Med Bull 2008; 7(1.000: 53-58

  4. 78 FR 5186 - Clinical Flow Cytometry in Hematologic Malignancies; Public Workshop; Request for Comments

    Science.gov (United States)

    2013-01-24

    ... monoclonal antibodies and flow cytometry contributed to the automation of lymphocyte subset analysis. Flow cytometric lymphocyte subset analysis was initially used to immunophenotype hematological malignancies; however, the HIV epidemic led to a large number of 510(k) submissions addressing use for HIV...

  5. 21 CFR 870.3450 - Vascular graft prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Vascular graft prosthesis. 870.3450 Section 870... prosthesis. (a) Identification. A vascular graft prosthesis is an implanted device intended to repair... Prostheses 510(k) Submissions.”...

  6. 78 FR 32287 - Self-Regulatory Organizations; ICE Clear Europe Limited; Notice of Filing of Proposed Rule Change...

    Science.gov (United States)

    2013-05-29

    ... Clear Europe financial, managerial, operational and similar resources dedicated to the clearing function... role in ICE Clear Europe' clearing operations for the LIFFE securities products. The clearing of the... believes it will have the operational and managerial capacity to clear the LIFFE Contracts as of...

  7. The Research on Submissive Behaviour of Students in the Second Level of Elementary School

    Directory of Open Access Journals (Sweden)

    Abdullah ATLİ

    2010-04-01

    Full Text Available This study examined the submissive behaviors of second level of elementary school students at with respect to some variables. Participants were 430 students, 172 (42,6 % girls and 231 (57,4 % boys. Among these participants, 156 (38,6 % were 6th graders, 104 (26% were 7th graders, and 143 (35,4% were 8th graders. The data were collected using Student Personal Information Form developed by researchers and Submissive Behaviors Scale. The data collected were analyzed using t-test, One-way ANOVA, Tukey Test, and Mann–Whitney U test. The findings revealed that students’ levels of submissive behaviors significantly differed by the variables including school type, gender, school class level, achievement, residence, economic level, mother’s and father’s education level, violence by mother and father.

  8. Toxic Substances Control Act test submissions database (TSCATS) - comprehensive update. Data file

    International Nuclear Information System (INIS)

    The Toxic Substances Control Act Test Submissions Database (TSCATS) was developed to make unpublished test data available to the public. The test data is submitted to the U.S. Environmental Protection Agency by industry under the Toxic Substances Control Act. Test is broadly defined to include case reports, episodic incidents, such as spills, and formal test study presentations. The database allows searching of test submissions according to specific chemical identity or type of study when used with an appropriate search retrieval software program. Studies are indexed under three broad subject areas: health effects, environmental effects and environmental fate. Additional controlled vocabulary terms are assigned which describe the experimental protocol and test observations. Records identify reference information needed to locate the source document, as well as the submitting organization and reason for submission of the test data

  9. Changes in publication statistics when electronic submission was introduced in an international applied science journal

    Directory of Open Access Journals (Sweden)

    Howard J. Swatland

    2008-12-01

    Full Text Available In a refereed journal in the food and agriculture sector, papers were tracked over a five-year period during the introduction of electronic submissions. Papers originated in the Americas and Pacific region and were processed in Canada. Acceptance times for revised papers were reduced (P < 0.001 to 59% of the original, from 156.5 ± 69.1 days to 92.8 ± 57.5 days. But the start of electronic submission coincided with a change in the geographical origin of papers, with papers from Anglophone countries changing from a 61% majority to a 42% minority. It is possible that submissions from non-Anglophone sources were facilitated, thus creating challenges to the traditional Anglophone reviewer population.

  10. Simplified three-dimensional tissue clearing and incorporation of colorimetric phenotyping.

    Science.gov (United States)

    Sung, Kevin; Ding, Yichen; Ma, Jianguo; Chen, Harrison; Huang, Vincent; Cheng, Michelle; Yang, Cindy F; Kim, Jocelyn T; Eguchi, Daniel; Di Carlo, Dino; Hsiai, Tzung K; Nakano, Atsushi; Kulkarni, Rajan P

    2016-01-01

    Tissue clearing methods promise to provide exquisite three-dimensional imaging information; however, there is a need for simplified methods for lower resource settings and for non-fluorescence based phenotyping to enable light microscopic imaging modalities. Here we describe the simplified CLARITY method (SCM) for tissue clearing that preserves epitopes of interest. We imaged the resulting tissues using light sheet microscopy to generate rapid 3D reconstructions of entire tissues and organs. In addition, to enable clearing and 3D tissue imaging with light microscopy methods, we developed a colorimetric, non-fluorescent method for specifically labeling cleared tissues based on horseradish peroxidase conversion of diaminobenzidine to a colored insoluble product. The methods we describe here are portable and can be accomplished at low cost, and can allow light microscopic imaging of cleared tissues, thus enabling tissue clearing and imaging in a wide variety of settings. PMID:27498769

  11. MO-F-16A-08: Have An Impact On More Patients From Your Ideas And Inventions

    International Nuclear Information System (INIS)

    Purpose: To inform physicists how to obtain an FDA 510(k) clearance for the innovations they use in their facility and to make those ideas widely available to patients throughout the U.S. Methods: Give advice from 20 years experience of assisting in well over 100 successful 510(k) clearances. Results: Learn how to develop a 510(k) submission. Conclusion: Many physicists, physicians and radiation therapists have developed innovations that that are helpful to the patients in their institution. But, many of these innovations deserve to be made available to patients throughout the United States. The author, a Certified Radiological Physicist and former FDA employee, has consulted for over twenty years for inventors, start-ups and established medical device manufacturers to bring new devices to market in the U.S. and to assist them to established FDA compliant quality systems for manufacturing. In this presentation the audience will learn the important points for deciding to go forward with obtaining a Premarket Notification clearance [also known as a 510(k) clearance] to legally market a medical device in the United States. The FDA has published guidelines for submitting a 510(k) application. However, the methods used to efficiently develop the documentation for submission and to obtain clearance in the shortest possible time comes from the author's experience in assisting well over one hundred successful 510(k) clearances.Whether you want to start your own company or to market your idea to an established medical device manufacturer, the value of your innovation increases with a documented 510(k) clearance from FDA

  12. Following dimethyl sulfoxide skin optical clearing dynamics with quantitative nonlinear multimodal microscopy

    OpenAIRE

    Zimmerley, Maxwell; McClure, R. Anthony; Choi, Bernard; Potma, Eric Olaf

    2009-01-01

    Second-harmonic generation (SHG) imaging is combined with coherent anti-Stokes Raman scattering (CARS) microscopy to follow the process of optical clearing in human skin ex vivo using dimethyl sulfoxide (DMSO) as the optical clearing agent. SHG imaging revealed that DMSO introduces morphological changes to the collagen I matrix. By carefully measuring the dynamic tissue attenuation of the coherent nonlinear signal, using CARS reference signals during the clearing process, it is found that DMS...

  13. Clear cell variant of calcifying epithelial odontogenic tumor of maxilla: Report of a rare case

    Directory of Open Access Journals (Sweden)

    Dinesh Badrashetty

    2013-01-01

    Full Text Available The calcifying epithelial odontogenic tumor (CEOT is a rare benign tumor of the jaws. Pindborg′s tumor having clear cells is extremely rare. Twelve central lesions have been reported of which only three cases have occurred in maxilla. Clear cell variant is a distinct entity, has more aggressive biological behavior and higher chances of recurrence. Hence it is important that presence of clear cells be included in histopathological diagnosis. Here we present a rare case of clear cell CEOT having aggressive behavior.

  14. The Research on Submissive Behaviour of Students in the Second Level of Elementary School

    OpenAIRE

    ATLİ, Abdullah; KAYA, Alim; Zerrin Bölükbaşı MACİT

    2010-01-01

    This study examined the submissive behaviors of second level of elementary school students at with respect to some variables. Participants were 430 students, 172 (42,6 %) girls and 231 (57,4 %) boys. Among these participants, 156 (38,6 %) were 6th graders, 104 (26%) were 7th graders, and 143 (35,4%) were 8th graders. The data were collected using Student Personal Information Form developed by researchers and Submissive Behaviors Scale. The data collected were analyzed using t-test, One-way A...

  15. A Web Support System for Submission and Handling of Programming Assignments

    DEFF Research Database (Denmark)

    Nørmark, Kurt

    2011-01-01

    Individual submission of programming assignments should be considered in all introductory programming courses. We describe a custom web support system for submission and management of programming assignments in an introductory C programming course. Experience from the first time use of the system...... is reported. In addition, we compare the pattern of use with the results of the final exam in order to reveal a possible impact of the programming assignments. We summarize the lessons learned in preparation for improving the system prior to the next round of use in the fall of 2011....

  16. The investigation of hopelessness and submissive acts as psycho-social facts in pubescents living in poor families

    Directory of Open Access Journals (Sweden)

    Songül Tümkaya

    2010-04-01

    Full Text Available The purpose of this study is to determine socio-demographic characteristics of pubescents living in poor families and the relationships between these characteristics and hopelessness and submissive acts. The sample of the study consists of 280 pubescents, who are living in poor families and attending high schools placing in Adana city Yuregir district during fall semester of 2008. 164 students in the sample are female and 116 students are male. Data is collected from “Socio-demographic Level Scale”, “Beck Hopelessness Scale” and “Submissive Acts Scale”. For statistical analysis, t-test, one way variance analysis (ANOVA, correlation analysis and LSD test are used. At the end of the study, following results are determined: Girls have more submissive acts than boys and boys are more hopeless than girls; the pubescents not born in Adana have more submissive acts and hopelessness than the pubescents born in Adana; there is no significant relationship between submissive acts and age, but there is significant relationship between hopelessness level and age; the pubescents living in low-income families are more hopeless than others; the number of individuals in family is an effective variable only for hopelessness, thus the hopelessness increases with the number of individuals in family; there is no significant difference between the students’ submissive acts and between their hopelessness based on their families’ income levels and jobs; a significant but low relationship at .01 level is found between hopelessness and submissive acts.

  17. 75 FR 51305 - Joint Public Roundtable on Governance and Conflicts of Interest in the Clearing and Listing of...

    Science.gov (United States)

    2010-08-19

    ... August 20, 2010, commencing at 9 a.m. and ending at 12 p.m., staff of the Agencies will hold a public..., August 20, 2010, commencing at 9 a.m. and ending at 12 p.m. Members of the public who wish to submit..., DC 20549-1090; or Electronic submission to the e-mail address provided on the CFTC's...

  18. On the Optimization of GLite-Based Job Submission

    International Nuclear Information System (INIS)

    A Grid is a very dynamic, complex and heterogeneous system, whose reliability can be adversely conditioned by several different factors such as communications and hardware faults, middleware bugs or wrong configurations due to human errors. As the infrastructure scales, spanning a large number of sites, each hosting hundreds or thousands of hosts/resources, the occurrence of runtime faults following job submission becomes a very frequent and phenomenon. Therefore, fault avoidance becomes a fundamental aim in modern Grids since the dependability of individual resources spread upon widely distributed computing infrastructures and often used outside of their native organizational boundaries, cannot be guaranteed in any systematic way. Accordingly, we propose a simple job optimization solution based on a user-driven fault avoidance strategy. Such strategy starts from the introduction within the grid information system of several on-line service-monitoring metrics that can be used as specific hints to the workload management system for driving resource discovery operations according to a fault-free resource-scheduling plan. This solution, whose main goal is to minimize the execution time by avoiding execution failures, demonstrated to be very effective in incrementing both the user perceivable quality and the overall grid performance.

  19. Grant Application Development, Submission, Review, and Award Infographic

    Science.gov (United States)

    This infographic shows the National Cancer Institute general timeline progression through Grant Application Development, Submission, Review, and Award Infographic. In the first month, Applicant prepares and submits Grant Application to Grants.gov in response to FOA. In month two, The Center for Scientific Review (CSR) assigns applications that fall under the category of R01s, etc. to a Scientific Review Group (SRG) or the CSR assigns applications that fall under the category of Program Projects and Center Grants to NCI Division of Extramural Activities (DEA). Months four through five: First-level review by Scientific Review Group (SRG) for Scientific Merit: SRG assigns Impact Scores. Month five Summary Sstatements are prepared and are available to NCI Program staff and applicants. Month six, second-level review by National Cancer Advisory board (NCAB) for NCI Funding determination begins. NCAB makes recommendation to NCI Director, NCI develops funding plan, Applications selected for Funding, “Paylists” forwarded to Office of Grant Administration (OGA). Month ten, Award Negotiations and Issuance: Award issued, Award received by Institution, and Investigator begins work. www.cancer.gov Icons made by Freepik from http://www.flaticon.com is licensed by CC BY3.0

  20. 77 FR 74283 - Clearing Requirement Determination Under Section 2(h) of the CEA

    Science.gov (United States)

    2012-12-13

    ... currency non-deliverable forwards to meet its proposed mandatory clearing criteria. Additional swaps will... credit default swaps (CDS) and interest rate swaps, described herein, be cleared by a derivatives... Comments C. Credit Default Swaps D. Determination Analysis for Credit Default Swaps E. Interest Rate...

  1. Characterizing the Effects of a Vertical Time Threshold for a Class of Well-Clear Definitions

    Science.gov (United States)

    Upchurch, Jason M.; Munoz, Cesar A.; Narkawicz, Anthony J.; Consiglio, Maria C.; Chamberlain James P.

    2015-01-01

    A fundamental requirement for the integration of unmanned aircraft into civil airspace is the capability of aircraft to remain well clear of each other and avoid collisions. This requirement has led to a broad recognition of the need for an unambiguous, formal definition of well clear. It is further recognized that any such definition must be interoperable with existing airborne collision avoidance systems (ACAS). A particular class of well-clear definitions uses logic checks of independent distance thresholds as well as independent time thresholds in the vertical and horizontal dimensions to determine if a well-clear violation is predicted to occur within a given time interval. Existing ACAS systems also use independent distance thresholds, however a common time threshold is used for the vertical and horizontal logic checks. The main contribution of this paper is the characterization of the effects of the decoupled vertical time threshold on a well-clear definition in terms of (1) time to well-clear violation, and (2) interoperability with existing ACAS. The paper provides governing equations for both metrics and includes simulation results to illustrate the relationships. In this paper, interoperability implies that the time of well-clear violation is strictly less than the time a resolution advisory is issued by ACAS. The encounter geometries under consideration in this paper are initially well clear and consist of constant-velocity trajectories resulting in near-mid-air collisions.

  2. 78 FR 41161 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing of Advance...

    Science.gov (United States)

    2013-07-09

    ... management practices are adequate for current clearing activity, OCC proposes to implement risk modeling... COMMISSION Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing of Advance... enhancements in OCC's margin model for longer-tenor options (i.e., those options with at least three years...

  3. 78 FR 75528 - Federal Government Participation in the Automated Clearing House

    Science.gov (United States)

    2013-12-12

    ... House AGENCY: Bureau of the Fiscal Service, Treasury. ACTION: Notice of proposed rulemaking with request... proposing to amend its regulation governing the use of the Automated Clearing House (ACH) system by Federal... of Subjects in 31 CFR Part 210 Automated Clearing House, Electronic funds transfer,...

  4. 33 CFR 263.24 - Authority for snagging and clearing for flood control (Section 208).

    Science.gov (United States)

    2010-07-01

    ... clearing for flood control (Section 208). 263.24 Section 263.24 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE CONTINUING AUTHORITIES PROGRAMS Flood Control Policy § 263.24 Authority for snagging and clearing for flood control (Section 208). (a)...

  5. 78 FR 58576 - Self-Regulatory Organizations; ICE Clear Europe Limited; Notice of Filing and Immediate...

    Science.gov (United States)

    2013-09-24

    ... markets to move trading in those contracts to ICE Endex. The changes to the General Contract Terms and ICE OTC Contract Standard Contract Terms and Eligibility Criteria consist of conforming changes that... similar to those currently traded on ICE Futures Europe and cleared by ICE Clear Europe. Acceptance of...

  6. 77 FR 6335 - Protection of Cleared Swaps Customer Contracts and Collateral; Conforming Amendments to the...

    Science.gov (United States)

    2012-02-07

    ... ``major swap participant.'' See 75 FR 80173, Dec. 21, 2010. Section 724 of the Dodd-Frank Act prescribes... for Mandatory Clearing, 76 FR 44464, July 26, 2011 (final rule); Derivatives Clearing Organizations General Provisions and Core Principles, 76 FR 69334, Nov. 8, 2011 (final rule). A DCO has...

  7. 76 FR 7236 - Self-Regulatory Organizations; Stock Clearing Corporation of Philadelphia; Boston Stock Exchange...

    Science.gov (United States)

    2011-02-09

    ... Release No. 59858 (May 4, 2009), 74 FR 22191 (May 12, 2009) (SR-NASDAQ-2009-039). Prior to the closing of... COMMISSION Self-Regulatory Organizations; Stock Clearing Corporation of Philadelphia; Boston Stock Exchange... is hereby given that on January 19, 2011, Stock Clearing Corporation of Philadelphia, Inc....

  8. Tongue-Palate Contact Pressure, Oral Air Pressure, and Acoustics of Clear Speech

    Science.gov (United States)

    Searl, Jeff; Evitts, Paul M.

    2013-01-01

    Purpose: The authors compared articulatory contact pressure (ACP), oral air pressure (Po), and speech acoustics for conversational versus clear speech. They also assessed the relationship of these measures to listener perception. Method: Twelve adults with normal speech produced monosyllables in a phrase using conversational and clear speech.…

  9. Apoptotic Cells Are Cleared by Directional Migration and elmo1-Dependent Macrophage Engulfment

    NARCIS (Netherlands)

    van Ham, Tjakko J.; Kokel, David; Peterson, Randall T.

    2012-01-01

    Apoptotic cell death is essential for development and tissue homeostasis [1, 2]. Failure to clear apoptotic cells can ultimately cause inflammation and autoimmunity [3, 4]. Apoptosis has primarily been studied by staining of fixed tissue sections, and a clear understanding of the behavior of apoptot

  10. Patterns of spread of clear cell ovarian cancer: Case report and case series ☆

    OpenAIRE

    Kumar, Aalok; Gilks, C. Blake; Mar, Colin; Santos, Jennifer; Tinker, Anna V.

    2013-01-01

    Highlights • Although patterns of metastases in ovarian clear cell cancer are not well described, patients may initially present with bone metastases. • Clear cell carcinoma with bone metastases is responsive to radiation therapy. • Bone metastases are not common in patients with ovarian high grade serous cancer.

  11. 75 FR 79992 - End-User Exception to Mandatory Clearing of Security-Based Swaps

    Science.gov (United States)

    2010-12-21

    ... in connection with such transactions. As a result, it is possible that the costs for an end-user to... with authority to adopt rules governing the end-user clearing exception and to prescribe rules, issue...) requires an SEC Filer invoking the end-user clearing exception to specify its SEC Central Index Key...

  12. 78 FR 75413 - Self-Regulatory Organizations; National Securities Clearing Corporation; Order Approving Proposed...

    Science.gov (United States)

    2013-12-11

    ... Periods \\102\\ prima facie has the effect of limiting that obligation to a subset of Clearing Members... FR at 62847. NSCC's application of the Special SLD funding obligation to no more than the 30 Clearing... Supervision Act of 2010 and Rule 19b-4(n)(1)(i) thereunder. See Release No. 34-69451 (Apr. 25, 2013), 78...

  13. Ion clearing and photoelectron production in the 200 MeV SXLS ring

    International Nuclear Information System (INIS)

    The X-ray Lithography Source (XLS) offers a unique opportunity to study both ion clearing and photoelectron production since its energy can be ramped from 60 to 200 MeV which represents critical photon energy var-epsilon c between 0.8 and 30 eV. The installed clearing electrodes collect not only positive ions produced by the circulating electron beam but also expel photoelectrons which are created in much larger quantities when clearing electrodes (CEs) are hit by synchrotron radiation. At var-epsilon c = 0.8 eV the photoelectron production decreases six orders of magnitude when compared to var-epsilon c = 30 eV and direct clearing (positive ion) current measurements become possible. The design of the SXLS clearing system and its behavior are presented. In normal 200 MeV operation, clearing electrode current is dominated by photoelectrons. Clearing electrodes appear essential only in several locations but not in the dipoles. The effect of clearing voltage on the tune and the beam profile is also discussed

  14. Tumor signatures of PTHLH overexpression, high serum calcium, and poor prognosis were observed exclusively in clear cell but not non clear cell renal carcinomas

    International Nuclear Information System (INIS)

    High serum calcium (Ca) due to aberrant secretion of tumor parathyroid hormone-like hormone (PTHLH) is a well-known paraneoplastic sign and is associated with poor prognosis in patients with renal cell carcinoma (RCC). However, the status of serum Ca and tumor PTHLH expression have not been verified using the 2004 World Health Organization (WHO) renal tumor classification. We retrospectively reviewed corrected serum Ca levels at initial onset (n = 683) and/or as of recurrence (n = 71) in patients with RCC. We also examined a total of 623 renal parenchymal tumor samples for PTHLH mRNA expressions by quantitative real-time PCR. High serum Ca concomitant with PTHLH overexpression in tumors was observed exclusively in clear cell RCC but not in other non clear cell subtype tumors, including papillary, chromophobe, collecting-duct, unclassified, and other rare subtype RCCs or in benign oncocytomas and angiomyolipomas. In clear cell RCC, PTHLH expression was significantly high in male patients, and was associated with a symptomatic presentation, higher grade, and higher stage cases, whereas it was not associated with VHL gene status. Univariate analyses demonstrated that high PTHLH expression was strongly associated with poor outcome both in overall survival (OS) and disease-free survival (DFS) for patients who underwent standard nephrectomy. Further multivariate Cox analyses revealed that the PTHLH expressions remained as independent prognostic parameters for OS but not for DFS. These data suggest that the previously characterized tumor signatures of high serum Ca due to high PTHLH expression and poor prognosis are clear cell RCC-specific features, whereas these characteristics are rare in non clear cell RCCs

  15. Optical clearing for luminal organ imaging with ultrahigh-resolution optical coherence tomography.

    Science.gov (United States)

    Liang, Yanmei; Yuan, Wu; Mavadia-Shukla, Jessica; Li, Xingde

    2016-08-01

    The imaging depth of optical coherence tomography (OCT) in highly scattering biological tissues (such as luminal organs) is limited, particularly for OCT operating at shorter wavelength regions (such as around 800 nm). For the first time, the optical clearing effect of the mixture of liquid paraffin and glycerol on luminal organs was explored with ultrahigh-resolution spectral domain OCT at 800 nm. Ex vivo studies were performed on pig esophagus and bronchus, and guinea pig esophagus with different volume ratios of the mixture. We found that the mixture of 40% liquid paraffin had the best optical clearing effect on esophageal tissues with a short effective time of ∼ 10 min, which means the clearing effect occurs about 10 min after the application of the clearing agent. In contrast, no obvious optical clearing effect was identified on bronchus tissues. PMID:27335154

  16. Clear Cell Sarcoma of Gluteal Region Malignant Melanoma of Soft Parts

    Directory of Open Access Journals (Sweden)

    Haren V. Oza

    2013-04-01

    Full Text Available Clear cell sarcoma (CCS is described as variant of sarcoma characterized by prominent clear cells showing features similar to malignant melanoma of soft parts. This neoplasm was first described by Dr. Franz m. Enzinger. Primary CCS usually arises in deeper soft tissues, in association with fascia, tendons, or aponeuroses. Clear cell sarcoma (CCS is a rare malignant tumor with a propensity for slow progressive invasion. It is a tumor derived from Melanoblast like cell. They occur most commonly in the extremities, with a predilection for young females. Clear cell sarcoma of tendons and aponeuroses (malignant melanoma of soft parts and conventional malignant melanoma may demonstrate significant morphologic overlap at the light microscopic and ultra structural level. The tumor is very rare and can pose clinical challenges in early diagnosis. This case report demonstrates an unusual site of occurrence for clear cell sarcoma. [Natl J Med Res 2013; 3(2.000: 193-195

  17. A Family of Well-Clear Boundary Models for the Integration of UAS in the NAS

    Science.gov (United States)

    Munoz, Cesar A.; Narkawicz, Anthony; Chamberlain, James; Consiglio, Maria; Upchurch, Jason

    2014-01-01

    The FAA-sponsored Sense and Avoid Workshop for Unmanned Aircraft Systems (UAS) defines the concept of sense and avoid for remote pilots as "the capability of a UAS to remain well clear from and avoid collisions with other airborne traffic." Hence, a rigorous definition of well clear is fundamental to any separation assurance concept for the integration of UAS into civil airspace. This paper presents a family of well-clear boundary models based on the TCAS II Resolution Advisory logic. For these models, algorithms that predict well-clear violations along aircraft current trajectories are provided. These algorithms are analogous to conflict detection algorithms but instead of predicting loss of separation, they predict whether well-clear violations will occur during a given lookahead time interval. Analytical techniques are used to study the properties and relationships satisfied by the models.

  18. Preparation of Samples for Leaf Architecture Studies, A Method for Mounting Cleared Leaves

    Directory of Open Access Journals (Sweden)

    Alejandra Vasco

    2014-09-01

    Full Text Available Premise of the study: Several recent waves of interest in leaf architecture have shown an expanding range of approaches and applications across a number of disciplines. Despite this increased interest, examination of existing archives of cleared and mounted leaves shows that current methods for mounting, in particular, yield unsatisfactory results and deterioration of samples over relatively short periods. Although techniques for clearing and staining leaves are numerous, published techniques for mounting leaves are scarce. Methods and Results: Here we present a complete protocol and recommendations for clearing, staining, and imaging leaves, and, most importantly, a method to permanently mount cleared leaves. Conclusions: The mounting protocol is faster than other methods, inexpensive, and straightforward; moreover, it yields clear and permanent samples that can easily be imaged, scanned, and stored. Specimens mounted with this method preserve well, with leaves that were mounted more than 35 years ago showing no signs of bubbling or discoloration.

  19. Identification of novel therapeutic targets in microdissected clear cell ovarian cancers.

    Directory of Open Access Journals (Sweden)

    Michael P Stany

    Full Text Available Clear cell ovarian cancer is an epithelial ovarian cancer histotype that is less responsive to chemotherapy and carries poorer prognosis than serous and endometrioid histotypes. Despite this, patients with these tumors are treated in a similar fashion as all other ovarian cancers. Previous genomic analysis has suggested that clear cell cancers represent a unique tumor subtype. Here we generated the first whole genomic expression profiling using epithelial component of clear cell ovarian cancers and normal ovarian surface specimens isolated by laser capture microdissection. All the arrays were analyzed using BRB ArrayTools and PathwayStudio software to identify the signaling pathways. Identified pathways validated using serous, clear cell cancer cell lines and RNAi technology. In vivo validations carried out using an orthotopic mouse model and liposomal encapsulated siRNA. Patient-derived clear cell and serous ovarian tumors were grafted under the renal capsule of NOD-SCID mice to evaluate the therapeutic potential of the identified pathway. We identified major activated pathways in clear cells involving in hypoxic cell growth, angiogenesis, and glucose metabolism not seen in other histotypes. Knockdown of key genes in these pathways sensitized clear cell ovarian cancer cell lines to hypoxia/glucose deprivation. In vivo experiments using patient derived tumors demonstrate that clear cell tumors are exquisitely sensitive to antiangiogenesis therapy (i.e. sunitinib compared with serous tumors. We generated a histotype specific, gene signature associated with clear cell ovarian cancer which identifies important activated pathways critical for their clinicopathologic characteristics. These results provide a rational basis for a radically different treatment for ovarian clear cell patients.

  20. On-chip clearing of arrays of 3-D cell cultures and micro-tissues.

    Science.gov (United States)

    Grist, S M; Nasseri, S S; Poon, T; Roskelley, C; Cheung, K C

    2016-07-01

    Three-dimensional (3-D) cell cultures are beneficial models for mimicking the complexities of in vivo tissues, especially in tumour studies where transport limitations can complicate response to cancer drugs. 3-D optical microscopy techniques are less involved than traditional embedding and sectioning, but are impeded by optical scattering properties of the tissues. Confocal and even two-photon microscopy limit sample imaging to approximately 100-200 μm depth, which is insufficient to image hypoxic spheroid cores. Optical clearing methods have permitted high-depth imaging of tissues without physical sectioning, but they are difficult to implement for smaller 3-D cultures due to sample loss in solution exchange. In this work, we demonstrate a microfluidic platform for high-throughput on-chip optical clearing of breast cancer spheroids using the SeeDB, Clear(T2), and ScaleSQ clearing methods. Although all three methods are able to effectively clear the spheroids, we find that SeeDB and ScaleSQ more effectively clear the sample than Clear(T2); however, SeeDB induces green autofluorescence while ScaleS causes sample expansion. Our unique on-chip implementation permits clearing arrays of 3-D cultures using perfusion while monitoring the 3-D cultures throughout the process, enabling visualization of the clearing endpoint as well as monitoring of transient changes that could induce image artefacts. Our microfluidic device is compatible with on-chip 3-D cell culture, permitting the use of on-chip clearing at the endpoint after monitoring the same spheroids during their culture. This on-chip method has the potential to improve readout from 3-D cultures, facilitating their use in cell-based assays for high-content drug screening and other applications. PMID:27493703