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Sample records for claus manniche md

  1. Polycyclic alkaloids via transannular Mannich reactions

    DEFF Research Database (Denmark)

    Vital, Paulo; Hosseini, Masood; Shanmugham, M. S.

    2009-01-01

    The tricyclic compound 13, representing the framework of the cylindricine 4 and lepadiformine 5 alkaloids, was prepared in a single operation via the first example of a transannular Mannich reaction involving a macrocyclic diketoamine 12.......The tricyclic compound 13, representing the framework of the cylindricine 4 and lepadiformine 5 alkaloids, was prepared in a single operation via the first example of a transannular Mannich reaction involving a macrocyclic diketoamine 12....

  2. Mannich reaction: A versatile and convenient approach to bioactive skeletons

    Indian Academy of Sciences (India)

    Selva Ganesan Subramaniapillai

    2013-05-01

    This review gives an insight into the recent applications of Mannich reaction and its variants in the construction of bioactive molecules. Emphasis is given to the Mannich reaction that provides bioactive molecules and/or modifies the property of an existing bioactive molecule. The role of Mannich reaction in the construction of antimalarial, antitumour, antimicrobial, antitubercular, antiinflammatory and anticonvulsant molecules and also the significance of aminoalkyl Mannich side chain on the biological property of molecules is discussed here.

  3. 40 CFR 721.4590 - Mannich-based adduct.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Mannich-based adduct. 721.4590 Section... Substances § 721.4590 Mannich-based adduct. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance generically identified as a Mannich-based adduct (PMN P-93-66)...

  4. Biosynthesis of some Mannich bases

    Directory of Open Access Journals (Sweden)

    Bruna S. D. R. Aranha

    2012-06-01

    Full Text Available The Mannich reaction is extremely useful to form molecules that contain nitrogen groups. Currently, there is a great interest turned to this class of compounds due to its biological properties. The recent literature reports that the utilization of enzymes can be an adequate methodology on this type of reaction. According to the exposed above and with the intention of synthesizing the -aminoketones, some catalysts like Chymosin and also some microorganisms such as Saccharomyces cerevisiae, (sourdough bread and Lactobacilos (ATCC 90827LA10N19.10-E.U.A were applied. These reactions were carried out by using water as solvent at room temperature excelling for the Green Chemistry principles. Figure 1 shows the reaction scheme involving 1 eq.mol of aniline, 1,3 eq.mol of formaldehyde, 10 ml of water and 0,25g of the catalyst during four days. The reaction furnished satisfactory yields which are in accordance with the literature data.

  5. Mannich Bases: An Important Pharmacophore in Present Scenario

    Directory of Open Access Journals (Sweden)

    Suman Bala

    2014-01-01

    Full Text Available Mannich bases are the end products of Mannich reaction and are known as beta-amino ketone carrying compounds. Mannich reaction is a carbon-carbon bond forming nucleophilic addition reaction and is a key step in synthesis of a wide variety of natural products, pharmaceuticals, and so forth. Mannich reaction is important for the construction of nitrogen containing compounds. There is a number of aminoalkyl chain bearing Mannich bases like fluoxetine, atropine, ethacrynic acid, trihexyphenidyl, and so forth with high curative value. The literature studies enlighten the fact that Mannich bases are very reactive and recognized to possess potent diverse activities like anti-inflammatory, anticancer, antifilarial, antibacterial, antifungal, anticonvulsant, anthelmintic, antitubercular, analgesic, anti-HIV, antimalarial, antipsychotic, antiviral activities and so forth. The biological activity of Mannich bases is mainly attributed to α, β-unsaturated ketone which can be generated by deamination of hydrogen atom of the amine group.

  6. Mannich bases in medicinal chemistry and drug design.

    Science.gov (United States)

    Roman, Gheorghe

    2015-01-07

    The biological activity of Mannich bases, a structurally heterogeneous class of chemical compounds that are generated from various substrates through the introduction of an aminomethyl function by means of the Mannich reaction, is surveyed, with emphasis on the relationship between structure and biological activity. The review covers extensively the literature reports that have disclosed Mannich bases as anticancer and cytotoxic agents, or compounds with potential antibacterial and antifungal activity in the last decade. The most relevant studies on the activity of Mannich bases as antimycobacterial agents, antimalarials, or antiviral candidates have been included as well. The review contains also a thorough coverage of anticonvulsant, anti-inflammatory, analgesic and antioxidant activities of Mannich bases. In addition, several minor biological activities of Mannich bases, such as their ability to regulate blood pressure or inhibit platelet aggregation, their antiparasitic and anti-ulcer effects, as well as their use as agents for the treatment of mental disorders have been presented. The review gives in the end a brief overview of the potential of Mannich bases as inhibitors of various enzymes or ligands for several receptors.

  7. Direct Catalytic Asymmetric Mannich-Type Reaction of Alkylamides.

    Science.gov (United States)

    Arteaga, Fernando Arteaga; Liu, Zijian; Brewitz, Lennart; Chen, Jianyang; Sun, Bo; Kumagai, Naoya; Shibasaki, Masakatsu

    2016-05-20

    Direct enolate formation coupled with subsequent enantioselective C-C bond formation remains a topic of intense interest in asymmetric catalysis. This methodology is achieved even with low acidic amides without an electron-withdrawing group at the α-position in the context of a Mannich-type reaction. Acetate-, propionate-, and butyrate-type 7-azaindoline amides served as enolate precursors to afford the desired Mannich adducts with high stereoselectivity, and ligand-enabled diastereo-divergency provided access to both anti/syn diastereomers. The facile transformation of the amide moiety ensures the synthetic utility of the Mannich adducts.

  8. COMBINATORIAL SYNTHESIS OF MANNICH BASES IN SOLUTION/POLYMER REAGENT WORKUP

    Institute of Scientific and Technical Information of China (English)

    HUANGWenqiang; CHENGShaoling; 等

    2000-01-01

    This paper describes a combinatorial synthesis the mannich bases in Solution through the Mannich reaction using 3 ketones,5 amines and formaldehyde in solution and hydrochloride as a catalyst and then using a macroporous quarterized ammonium resin(CO32-form)as a scavenge agent to remove the acid catalyst when the Mannich reaction is completed.It was found by GC/MS analysis that the symmetrical ketone,such as acetone,in the Mannich reaction mainly produces one Mannich base;while the asymmetrical ketone,such as 2-pentanone,gives two.

  9. Stereoselective bioreduction of someMannich bases

    Directory of Open Access Journals (Sweden)

    Bruna S. D. R. Aranha

    2012-06-01

    Full Text Available The chemic reaction that happen on the live organism (plants, superior animals and microorganisms produce various chiral substances such as pheromones, antibiotics and others. After the eighties, with the break of the dogma referent to the enzymatic utilization only in aqueous medias, diverse enzyme application were revealed in other reaction medias, what allowed new studies turned to enzymatic application in organic chemistry. Such studies revealed that these biocatalysts presented high selectivity in these medias, no only about to the chemoselectivity but especially to the enantioselectivity. According to what was exposed, this work aimed to execute the bioreduction of some Mannich bases using the microorganism Saccharomyces cerevisiae (sourdough bread. Scheme 1 shows the reaction scheme involving 1 eq.mol of the b-aminocarbonilated product, 10 mL of   the suitable solvent and 0,5g of the biocatalys during four days at room temperature. These reactions presented satisfactory yields, which are in accordance with the literature.

  10. Are Subject Small Clauses Really Small Clauses?

    Science.gov (United States)

    Kubo, Miori

    1993-01-01

    This paper discusses the ongoing debate over small clauses concerning the structure of the verb phrase in "I consider Bill smart." It is demonstrated that the subject constituent in question is not a small clause, but a Noun Phrase (NP), following Noun (N). It is shown that some peculiar phenomena under the small clause analysis are natural…

  11. Claus Bonderup

    DEFF Research Database (Denmark)

    Fisker, Anna Marie; Hvejsel, Marie Frier; Tvedebrink, Tenna Doktor Olsen

    Ever since I was a young student and met Claus Bonderup for the first time, I have been fascinated by his work. I still remember how we turned up for a lecture of his at the Aarhus School of Architecture in the beginning of the 1980s brimming with excitement; a lecture that would end up being very...... at the Department of Civil Engineering, I have had the great pleasure of working with Claus for the last 15 years. During this time, I have had the opportunity to observe his skills as a teacher and disseminator, and I have seen the great respect he holds for young, dedicated people and witnessed the students......’ confidence in him. In 2008, we wrote a small book, the “old student” and the two “young graduates” from Architecture & Design, who, I would like to emphasise, are two very special young people that have now seriously entered the frame of architectural research and teaching. Now, in the late summer of 2012...

  12. Injection MD

    CERN Document Server

    Bartmann, W; Bracco, C; Drosdal, L; Gianfelice, E; Goddard, B; Kain, V; Papaphilippou, Y; Vanbavinckhove, G

    2012-01-01

    This note summarizes the results obtained at injection during the 2nd MD block and the floating MD block in July. Highlights are presented for injection in the LHC with the Q20 SPS optics, influence of the supercycle and injection with 25 ns bunch spacing. Beams were successfully injected into the LHC using the Q20 optics [1, 3]. Small corrections were needed to steer the beam in the transfer lines. Dispersion measurements were conducted for both beams. The horizontal normalized dispersion in TI2 was a factor 2 smaller for Q20 with respect to Q26, for TI8 on the other hand the opposite was observed. The results for injection loss dependency on super cycle composition show only a small increase in losses for beam 2. The losses observed must therefore mainly come from other sources such as shot-by-shot stability or quality of scraping. For the injection with 25 ns bunch spacing bunches were injected for both beams. For B1 up to the maximum of 288 bunches. For B2 on the other only up to 144 bunches were injected...

  13. Covered Clause Elimination

    CERN Document Server

    Heule, Marijn; Biere, Armin

    2010-01-01

    Generalizing the novel clause elimination procedures developed in [M. Heule, M. J\\"arvisalo, and A. Biere. Clause elimination procedures for CNF formulas. In Proc. LPAR-17, volume 6397 of LNCS, pages 357-371. Springer, 2010.], we introduce explicit (CCE), hidden (HCCE), and asymmetric (ACCE) variants of a procedure that eliminates covered clauses from CNF formulas. We show that these procedures are more effective in reducing CNF formulas than the respective variants of blocked clause elimination, and may hence be interesting as new preprocessing/simplification techniques for SAT solving.

  14. Lithium amide assisted asymmetric Mannich-type reactions of menthyl acetate with PMP-aldimines.

    Science.gov (United States)

    Hata, Seiji; Iguchi, Mayu; Iwasawa, Tetsuo; Yamada, Ken-ichi; Tomioka, Kiyoshi

    2004-05-27

    A lithium enolate of menthyl acetate added to PMP-imines, in the presence of an equimolar amount of lithium diisopropylamide, affords the Mannich-type addition products in high stereoselectivity. [reaction--see text

  15. Green chemistry approach to the synthesis of potentially bioactive aminobenzylated Mannich bases through active hydrogen compounds

    Directory of Open Access Journals (Sweden)

    S. L. VASOYA

    2005-10-01

    Full Text Available An efficient and high yield method for the synthesis of aminobenzylated Mannich bases is described. The synthesis occurs in aqueous medium at 0 ºC. The compounds show moderate antitubercular and antimicrobial activities.

  16. Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives

    Directory of Open Access Journals (Sweden)

    Denisa Leonte

    2015-07-01

    Full Text Available This paper describes the biocatalytic synthesis of new Mannich bases containing various heterocyclic rings (thiazole, furane, thiophene, pyridine by applying the lipase catalyzed trimolecular condensation of the corresponding heterocyclic aldehydes with acetone and primary aromatic amines, in mild and eco-friendly reaction conditions. The obtained Mannich bases were acylated to their corresponding N-acetyl derivatives. All compounds were characterized by 1H-NMR, 13C-NMR and MS spectrometry.

  17. Cryptanalysis of MD2

    DEFF Research Database (Denmark)

    Knudsen, Lars Ramkilde; Mathiassen, John Erik; Muller, Frédéric

    2010-01-01

    This paper considers the hash function MD2 which was developed by Ron Rivest in 1989. Despite its age, MD2 has withstood cryptanalytic attacks until recently. This paper contains the state-of-the-art cryptanalytic results on MD2, in particular collision and preimage attacks on the full hash...

  18. AN EXPLORATION ON THE SYNTHESIS AND BIO-APPLICATIONS OF DERIVATIVES OF HETEROCYCLIC MANNICH BASES

    Directory of Open Access Journals (Sweden)

    P. S. Manjula

    2016-01-01

    Full Text Available The Mannich reaction is a three-component reaction of an aldehyde, a primary or secondary amine and a ketone which is one of the most powerful C-C bond forming reactions in organic synthesis. It leads to β-amino carbonyl compounds, which are useful for the syntheses of nitrogen containing compounds, such as natural products and medicinally relevant compounds. The versatility and potential of these compounds to introduce both functional and structural diversity using the Mannich reaction have stimulated the creativity of chemists. Keeping in view of the importance of this organic moiety in the field of medicine and biology here an attempt has been made to review the synthesis and biological importance of heterocyclic Mannich base derivatives.

  19. Clause Types in Southeastern Tepehuan.

    Science.gov (United States)

    Willett, Thomas L.

    The clause in Southeastern Tepehuan consists of a predicate, its associated arguments, and other modifying elements. This paper seeks to show the various types of semantic and surface clauses and the relation between them. The semantic clause consists of various semantic components, both nuclear and peripheral, semantic prosodies, and certain…

  20. Iterative Specialisation of Horn Clauses

    DEFF Research Database (Denmark)

    Nielsen, Christoffer Rosenkilde; Nielson, Flemming; Nielson, Hanne Riis

    2008-01-01

    We present a generic algorithm for solving Horn clauses through iterative specialisation. The algorithm is generic in the sense that it can be instantiated with any decidable fragment of Horn clauses, resulting in a solution scheme for general Horn clauses that guarantees soundness and terminatio...

  1. An Overview of Relative Clauses

    Institute of Scientific and Technical Information of China (English)

    肖飒

    2015-01-01

    Relative clause is one kind of important modifiers among English grammar. It is a widely used clauses in English con-text. In order to get an overview of relative clause, this essay will analyze it in terms of form, meaning and use.

  2. MD SIMULATION FOR NANOCRYSTALS

    Institute of Scientific and Technical Information of China (English)

    马新玲; 杨卫

    2003-01-01

    Molecular dynamic (MD) provided an ab initio simulation for nano-scale mechanical behavior of materials, provided that the inter-atomic potential is accurately prescribed. MD is particularly suitable in simulating the formation, the deformation, and the evolution of nanocrystals under a fast strain rate. To tackle large scale system and nano-seconds time duration, parallel algorithm is desired. The present paper reviews the recent advances in MD simulation for nanocrystals with attention focused on the applications toward nanomechanics. The examined issues are: formation of nanocrystalline metals, nanoindentation on nanocrystals, fast deformation of nanocrystals, orderdisorder transition, and nano-particle impact.

  3. Synthesis, characterization and antimicrobial evaluation of some new schiff, mannich and acetylenic Mannich bases incorporating a 1,2,4-triazole nucleus.

    Science.gov (United States)

    Aouad, Mohamed R

    2014-11-18

    A series of Schiff and Mannich bases derived from 4-amino-5-(3-fluoro-phenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione were synthesized. The alkylation of 4-phenyl-5-(3-fluorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione with propargyl bromide afforded the corresponding thiopropargylated derivative which upon treatment with the appropriate secondary amines in the presence of CuCl2 furnished the desired acetylenic Mannich bases. The synthesized compounds were characterized on the basis of their spectral (IR, 1H- and 13C-NMR) data and evaluated for their biological activities. Some of the compounds were found to exhibit significant antimicrobial activity.

  4. Muscular Dystrophy (MD)

    Science.gov (United States)

    ... fight respiratory infections. Some individuals may benefit from occupational therapy and assistive technology. Some ... (MD) are a group of more than 30 genetic diseases characterized by progressive weakness and degeneration of the ...

  5. Claus Achton Friis

    DEFF Research Database (Denmark)

    Ejlers, Steen

    1996-01-01

    Grafiker, professor Claus Achton Friis 1917-1999 er en central skikkelse i det 20.århundredes danske brugsgrafik. Han er ophavsmand til en mængde emballager, frimærker og heraldik og desuden formgiver af en række fremragende skrifter. Han var elev af grafikeren professor Gunnar Biilmann Petersen og...

  6. Claus Madsen Retires

    Science.gov (United States)

    de Zeeuw, T.; Walsh, J.

    2016-12-01

    Claus Madsen began at ESO as a photographer in 1980 and recently retired as senior advisor on international relations. During his career he authored several books, the most notable being a history of ESO from the late 1980s to the 50th anniversary in 2012. A brief appreciation of his career is presented.

  7. RUTHENIUM-CATALYZED TANDEM OLEFIN MIGRATION-ALDOL AND MANNICH-TYPE REACTIONS IN IONIC LIQUID.

    Science.gov (United States)

    In the presence of a catalytic amount of RuCl2(PPh3)3, a cross-coupling of 3-buten-2-ol with aldehydes and imines was developed via a tandem olefin migration--aldol--Mannich reaction in bmim[PF6]. With In(OAc)3 as a co-catalyst, a-vinylbenzyl alcohol and aldehydes underwent sim...

  8. ALDOL- AND MANNICH-TYPE REACTIONS VIA IN SITU OLEFIN MIGRATION IN IONIC LIQUID

    Science.gov (United States)

    An aldol-type and a Mannich-type reaction via the cross-coupling of aldehydes and imines with allylic alcohols catalyzed by RuCl2(PPh3)3 was developed with ionic liquid as the solvent. The solvent/catalyst system could be reused for at least five times with no loss of reactiv...

  9. Ciprofloxacin containing Mannich base and its copper complex induce antitumor activity via different mechanism of action.

    Science.gov (United States)

    Fu, Yun; Yang, Yingli; Zhou, Sufeng; Liu, Youxun; Yuan, Yanbin; Li, Shaoshan; Li, Changzheng

    2014-11-01

    The Mannich base containing ciprofloxacin and kojic acid structural units was prepared and evaluated in antitumor activity. The enhancement in antitumor activity was observed both from the Mannich base (IC(50): 103.3±5.0 µM for HepG2, 87.9±8.0 µM for HCT-116 cell) and its copper complex (IC(50): 11.5±1.8 µM for HepG2, 44.4±2.5 µM for HCT-116 cell) compared to the ciprofloxacin and kojic acid. The mechanistic studies via RT-PCR, cell cycle analysis, mitochondrial membrane potential measurement, inhibition of topoisomerase and molecular docking indicated that there is a different molecular mechanism between the Mannich base and its copper complex. The cytotoxicity of the Mannich base was involved in apoptosis, cell cycle arrest, depolarization of mitochondrial membrane and weaker topoisomerase II inhibition, but the copper complex exerted its cytotoxicity mainly through dual topoisomerase inhibition, especially stabilizing the intermediate of cleavage DNA-topoisomerase complex.

  10. Chiral ammonium betaine-catalyzed asymmetric Mannich-type reaction of oxindoles

    Directory of Open Access Journals (Sweden)

    Masahiro Torii

    2016-09-01

    Full Text Available A highly diastereo- and enantioselective Mannich-type reaction of 3-aryloxindoles with N-Boc aldimines was achieved under the catalysis of axially chiral ammonium betaines. This catalytic method provides a new tool for the construction of consecutive quaternary and tertiary stereogenic carbon centers on biologically intriguing molecular frameworks with high fidelity.

  11. A Sustainable Protocol for the Aqueous Multicomponent Petasis Borono-Mannich Reaction

    Science.gov (United States)

    Candeias, Nuno R.; Paterna, Roberta; Cal, Pedro M. S. D.; Gois, Pedro M. P.

    2012-01-01

    A protocol for the preparation of Petasis borono-Mannich products suitable for advanced organic chemistry experiments, using water as a reaction medium, was developed. The experiment is carried out in less than 4 h (with a 30 min pre-session on the day before) using commercially available starting materials in the preparation of phenylglycine and…

  12. Tandem Mannich/Diels–Alder reactions for the synthesis of indole compound libraries

    DEFF Research Database (Denmark)

    Wu, Peng; Petersen, Michael Åxman; Petersen, Rico;

    2016-01-01

    A tandem Mannich/Diels–Alder sequence for the synthesis of small-molecule libraries with an indolyl-octahydro-3a,6-epoxy-isoindole core structure is demonstrated in this study. Representative diversification examples based on this scaffold were performed, and a library is being produced within th...

  13. Diastereoselective Ugi reaction of chiral 1,3-aminoalcohols derived from an organocatalytic Mannich reaction

    Directory of Open Access Journals (Sweden)

    Samantha Caputo

    2016-01-01

    Full Text Available Enantiomerically pure β-aminoalcohols, produced through an organocatalytic Mannich reaction, were subjected to an Ugi multicomponent reaction under classical or Lewis acid-promoted conditions with diastereoselectivities ranging from moderate to good. This approach represents a step-economical path to enantiomerically pure, polyfunctionalized peptidomimetics endowed with three stereogenic centers, allowing the introduction of five diversity inputs.

  14. MD-2 binds cholesterol.

    Science.gov (United States)

    Choi, Soo-Ho; Kim, Jungsu; Gonen, Ayelet; Viriyakosol, Suganya; Miller, Yury I

    2016-02-19

    Cholesterol is a structural component of cellular membranes, which is transported from liver to peripheral cells in the form of cholesterol esters (CE), residing in the hydrophobic core of low-density lipoprotein. Oxidized CE (OxCE) is often found in plasma and in atherosclerotic lesions of subjects with cardiovascular disease. Our earlier studies have demonstrated that OxCE activates inflammatory responses in macrophages via toll-like receptor-4 (TLR4). Here we demonstrate that cholesterol binds to myeloid differentiation-2 (MD-2), a TLR4 ancillary molecule, which is a binding receptor for bacterial lipopolysaccharide (LPS) and is indispensable for LPS-induced TLR4 dimerization and signaling. Cholesterol binding to MD-2 was competed by LPS and by OxCE-modified BSA. Furthermore, soluble MD-2 in human plasma and MD-2 in mouse atherosclerotic lesions carried cholesterol, the finding supporting the biological significance of MD-2 cholesterol binding. These results help understand the molecular basis of TLR4 activation by OxCE and mechanisms of chronic inflammation in atherosclerosis.

  15. Yttrium (III chloride catalyzed Mannich reaction: An efficient procedure for the synthesis of β-amino carbonyl compounds

    Directory of Open Access Journals (Sweden)

    Venkateswarlu Yekkirala

    2014-12-01

    Full Text Available Yttrium (III chloride catalyzed Mannich reaction of aldehydes with ketones and amines in acetonitrile at reflux temperature to give various β-amino carbonyl compounds in very good yields.

  16. Claus Dieter Classen, Religionsrecht

    OpenAIRE

    Thielmann, Jörn

    2007-01-01

    Claus Dieter Classen, professor for Public Law, European and International Law at the University of Greifswald (Germany), has written a comprehensive textbook on the relationship of the State and its legal system with religions and religious corporations by public law and religious associations in Germany, intended not only for jurists, but also for theologians and scholars of Religious Studies. The book is clearly structured and well written. It is divided in four main parts. Part One outlin...

  17. NMR study of the preparation of 6 {alpha}, 7 {beta}-dihydroxyvouacapan-17 beta-oic acid mannich base derivatives

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Flavio Jose Leite dos; Pilo-Veloso, Dorila [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte (Brazil). Inst. de Ciencias Exatas. Dept. Quimica]. E-mail: dorila@zeus.qui.ufmg.br; Ferreira-Alves, Dalton L. [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte (Brazil). Inst. de Ciencias Biologicas. Dept. de Farmacologia

    2007-07-01

    This work presents four new Mannich base compounds obtained by the Mannich reaction of a {delta}-keto-lactone derivative of 6{alpha}, 7{beta}-dihydroxyvouacapan- 17{beta}-oic acid, a furano diterpene isolated from the hexane extract of Pterodon polygalaeflorus Benth fruits, which shows anti-inflammatory and analgesic activities. The use of 1D and 2D NMR (COSY, DEPT-135, HMBC, HMQC) spectroscopy made it possible to characterize the new compounds. (author)

  18. Reação de Mannich: Metodologia Clássica na Formação de Ligação Carbono-Carbono

    Directory of Open Access Journals (Sweden)

    João Francisco Allochio Filho

    2013-08-01

    Full Text Available The Mannich reaction is a classical method for the preparation of b-aminoketones and aldeydes (Mannich bases and, as such, is one the most important reaction in organic chemistry. The resulting Mannich bases are of particular interest due to their biological activity, use as synthetic building blocks, and precursors of valuable pharmaceuticals products. In this context, various elegant stereoselective α-aminoalkylations have been developed.

  19. Novel Mannich bases bearing pyrazolone moiety. Synthesis, characterization and electrochemical studies

    Directory of Open Access Journals (Sweden)

    KRISHNA NAIK

    2013-04-01

    Full Text Available The present investigation describes a series of new {4-[3-Methyl-5-oxo-4-(4|-substituted phenyl hydrazono-4,5-dihydro-pyrazol-1-yl]-phenoxy}-acetic acid (2-oxo-1-piperidine-1-ylmethyl-1,2-dihydro–indol-3-ylidene-hydrazides synthesized by the Mannich reaction of {4-[3-Methyl-5-oxo-4-(4|-substituted phenyl hydrazono-4,5-dihydro-pyrazol-1-yl]-phenoxy}-acetic acid (2-oxo-1,2-dihydro-indol-3-ylidene-hydrazide with aqueous formaldehyde and a solution of piperidine in dimethylformamide. These novel Mannich bases were characterized by elemental analysis, IR, 1H NMR and mass spectral data. Electrochemical behavior of these compounds were studied by two techniques namely polarography and cyclic voltammetry. The results from both the techniques were compared and the reduction mechanism in acidic as well as basic medium was proposed.

  20. Trimerization catalysis of phenylisocyanate in the presence of phenolic mannich bases

    Energy Technology Data Exchange (ETDEWEB)

    Selivanov, A.V.; Zenitova, L.A.; Bakirova, I.N.; Kirpichnikov, P.A.

    1988-11-01

    The kinetics of the cyclic trimerization of phenylisocyanate in the presence of phenolic Mannich bases have been studied by IR spectroscopy; a catalysis mechanism for the reaction is proposed. It was found that in order for trimerization to occur the catalyst molecule must contain both a hydroxyl group and a tertiary nitrogen atom, which leads to reaction at the OH group of the catalyst and its conversion via a urethane derivative to an allophanate; the latter species undergoes tautomeric rearrangement to a bipolar ion, which is the actual catalysis site. The effects of the number of aminomethyl, hydroxyl, and other electron-donating and electron-withdrawing substituents on the structure of Mannich bases have also been investigated.

  1. One-pot nitro-Mannich cascade reactions: new methodologies and synthetic applications

    OpenAIRE

    2011-01-01

    Pyrrolidine and pyrrolidinone rings are common motifs found in many biologically active natural products and drugs. Accordingly, our work focuses on the development of new methodologies for their one-pot synthesis. An efficient diastereoselective nitro-Mannich / lactamisation reaction cascade of methyl 3-nitropropanoate with cyclic and acyclic imines for the direct preparation of trans-monocyclic and fused tricyclic pyrrolidinone derivatives was developed. The reaction is easy to perform, ...

  2. Synthesis of 0,0-diethyl-α-(p-toluenesulphonamido) phosphonates by Mannich-type reaction

    Institute of Scientific and Technical Information of China (English)

    陈茹玉; 戴庆; 张殿坤; 杨秀凤

    1995-01-01

    A series of O,O-diethyl-α-(p-toluenesulphonamido)phosphonates have been synthesized by theMannich-type reaction of p-toluenesulphonamide,substituted benzaldehydes and diethyl phosphite with acetylchloride as the solvent.The mechanism of the reaction is suggested,and the structures of new products areconfirmed by 1H NMR,31p NMR,elemental analysis and X-ray diffraction.The results of preliminarybioassay showed that some of them possess herbicidal activities.

  3. Toxicity of some bis Mannich bases and corresponding piperidinols in the brine shrimp (Artemia salina) bioassay.

    Science.gov (United States)

    Gul, H Inci; Gul, Mustafa; Erciyas, Ercin

    2003-01-01

    Some acetophenone-derived bis Mannich bases were synthesized: bis[beta-benzoylethyl]ethylamine hydrochloride (IIa), bis[beta-(p-methylbenzoyl)ethyl]ethylamine hydrochloride (IIb), bis[beta-(p-chlorobenzoyl)ethyl]ethy- lamine hydrochloride (IId), bis[(2-thienylcarbonyl)ethyl]ethylamine hydrochloride (IIe); some corresponding piperidinol derivatives: 3-benzoyl-1-ethyl-4-phenyl-4-piperidinol hydrochloride (IIIa), 1-ethyl-3-(p-methyl- benzoyl)-4-(p-methylphenyl)-4-piperidinol hydrochloride (IIIb), 1-ethyl-3-(p-methoxybenzoyl)-4-(p-methoxy- phenyl)-4-piperidinol hydrochloride (IIIc), 1-ethyl-3-(p-chlorobenzoyl)-4-(p-chlorophenyl)-4-piperidinol hydrochloride (IIId), 1-ethyl-4-(2-thienyl)-3-(2-thienylcarbonyl)-4-piperidinol hydrochloride (IIIe); and some representative quaternary piperidinols: 3-benzoyl-1-ethyl-4-hydroxy-1-methyl-4-phenylpiperidinium iodide (IIIf), 1-ethyl-4-hydroxy-1-methyl-3-(p-methylbenzoyl)-4-(p-methylphenyl)piperidinium iodide (IIIg). Toxicity was tested by the brine shrimp bioassay as an intermediate test before further in vivo animal experiments. Piperidine derivatives were found to be more potent than bis Mannich bases. Quaternary piperidine derivatives IIIf and IIIg and also non-quaternary piperidine derivatives IIIb, IIIe, IIIc and IIId were more toxic than 5-fluorouracil in brine shrimp bioassay. Except for IIe, bis Mannich bases were not effective. Quaternization and conversion of bis Mannich bases to corresponding piperidines improved the toxicity. The lipid solubility of the compounds may not affect the toxicity. From these findings the quaternary piperidine derivatives IIIf and IIIg could be used in further drug development and also for in vivo experiments.

  4. Structural studies on Mannich bases of 2-Hydroxy-3,4,5,6-tetrachlorobenzene. An UV, IR, NMR and DFT study. A mini-review

    DEFF Research Database (Denmark)

    Hansen, Poul Erik; Spanget-Larsen, Jens

    2016-01-01

    Mannich bases of 2-Hydroxy-3,4,5,6-tetrachlorobenzene are chosen as an exemplary case for tautomeric Mannich bases. Molecular structures are calculated. OH stretching frequencies are rationalized based on DFT calculations. Intrinsic deuterium isotope effects on 13C chemical shifts in the M-form a...

  5. Synthesis and evaluation of novel triazoles and mannich bases functionalized 1,4-dihydropyridine as angiotensin converting enzyme (ACE) inhibitors.

    Science.gov (United States)

    Kumbhare, Ravindra M; Kosurkar, Umesh B; Bagul, Pankaj K; Kanwal, Abhinav; Appalanaidu, K; Dadmal, Tulshiram L; Banerjee, Sanjay Kumar

    2014-11-01

    A series of novel diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate embedded triazole and mannich bases were synthesized, and evaluated for their angiotensin converting enzyme (ACE) inhibitory activity. Screening of above synthesized compounds for ACE inhibition showed that triazoles functionalized compounds have better ACE inhibitory activity compared to that of mannich bases analogues. Among all triazoles we found 6 h, 6 i and 6 j to have good ACE inhibition activity with IC50 values 0.713 μM, 0.409 μM and 0.653 μM, respectively. Among mannich bases series compounds, only 7c resulted as most active ACE inhibitor with IC50 value of 0.928 μM.

  6. Modified Claus process probabilistic model

    Energy Technology Data Exchange (ETDEWEB)

    Larraz Mora, R. [Chemical Engineering Dept., Univ. of La Laguna (Spain)

    2006-03-15

    A model is proposed for the simulation of an industrial Claus unit with a straight-through configuration and two catalytic reactors. Process plant design evaluations based on deterministic calculations does not take into account the uncertainties that are associated with the different input variables. A probabilistic simulation method was applied in the Claus model to obtain an impression of how some of these inaccuracies influences plant performance. (orig.)

  7. Arnold Aberman, MD.

    Science.gov (United States)

    Aberman, A

    1995-10-01

    When the United States embarked on its effort to provide universal health insurance, the Canadian Medicare System was cited as a possible model for American health care. Often touted as an example of low-cost, high quality medicine, the Canadian system has mirrored the problems of health care across its southern border. With rocketing health care expenditures and financing having largely been decentralized to the individual provinces, local officials have struggled to cut costs and services. A central focus of these efforts has been a move to decrease the numbers of physicians, most notably a 10% decrease in medical school class size in 1993. While some Western provinces have experimented with the privatization of health care, the Canadian system still remains the epitome of government operated fee-for-service medicine. Given the likelihood of dramatic change in the American Medicare system, Canadian academic centers offer a unique perspective on the impact of capitation, evolving relationships with government payors, and the flip side of market oriented reforms. At the helm of one of Canada's largest schools is Arnold Aberman, MD, dean of the University of Toronto Faculty of Medicine. Born in Montreal, Quebec, Aberman received his MD from McGill University, but then did his residency both in Canada and the US, followed by a pulmonary fellowship at Albert Einstein College of Medicine and the Cardiovascular Research Institute of the University of California, San Francisco. Interviewed at his office in Toronto, Aberman reflected on the trials and tribulations confronting medicine on both sides of the 48th parallel.

  8. Choline-based biodegradable ionic liquid catalyst for Mannich-type reaction

    Indian Academy of Sciences (India)

    PENG HUAN; HU YULIN; XING RONG; FANG DONG

    2016-12-01

    A three-component Mannich-type reaction of aromatic aldehydes, ketones, and amines was catalyzed by a novel choline-based acidic ionic liquid. The proposed catalyst was a Lewis-BrØnsted dual acid catalyst as well as water-tolerant. The β-amino carbonyl compounds were obtained at room temperature in reasonable to good yields ranging from 63 to 98%. After the reaction, the catalyst could be recycled and reused for 5 times without obvious decrease of the yield. Further, the catalyst was environment-friendly with a significant biodegradation rate.

  9. Homologation of α-aryl amino acids through quinone-catalyzed decarboxylation/Mukaiyama-Mannich addition.

    Science.gov (United States)

    Haugeberg, Benjamin J; Phan, Johnny H; Liu, Xinyun; O'Connor, Thomas J; Clift, Michael D

    2017-03-09

    A new method for amino acid homologation by way of formal C-C bond functionalization is reported. This method utilizes a 2-step/1-pot protocol to convert α-amino acids to their corresponding N-protected β-amino esters through quinone-catalyzed oxidative decarboxylation/in situ Mukaiyama-Mannich addition. The scope and limitations of this chemistry are presented. This methodology provides an alternative to the classical Arndt-Eistert homologation for accessing β-amino acid derivatives. The resulting N-protected amine products can be easily deprotected to afford the corresponding free amines.

  10. ADT fast losses MD

    CERN Document Server

    Priebe, A; Dehning, B; Redaelli, S; Salvachua Ferrando, BM; Sapinski, M; Solfaroli Camillocci, M; Valuch, D

    2013-01-01

    The fast beam losses in the order of 1 ms are expected to be a potential major luminosity limitation for higher beam energies after the LHC long shutdown (LS1). Therefore a Quench Test is planned in the winter 2013 to estimate the quench limit in this timescale and revise the current models. This experiment was devoted to determination the LHC Transverse Damper (ADT) as a system for fast losses induction. A non-standard operation of the ADT was used to develop the beam oscillation instead of suppressing them. The sign flip method had allowed us to create the fast losses within several LHC turns at 450 GeV during the previous test (26th March 2012). Thus, the ADT could be potentially used for the studies of the UFO ("Unidentied Falling Object") impact on the cold magnets. Verification of the system capability and investigations of the disturbed beam properties were the main objectives of this MD. During the experiment, the pilot bunches of proton beam were excited independently in the horizontal and vertical ...

  11. Noun complement clauses as referential modifiers

    Directory of Open Access Journals (Sweden)

    Carlos de Cuba

    2017-01-01

    Full Text Available A number of recent analyses propose that so-called noun complement clauses should be analyzed as a type of relative clause. In this paper, I present a number of complications for any analysis that equates noun complement clauses to relative clauses, and conclude that this type of analysis is on the wrong track. I present cross-linguistic evidence showing that the syntactic behavior of noun complement clauses does not pattern with relative clauses. Patterns of complementizer choice and complementizer drop as well as patterns involving main clause phenomena and extraction differ in the two constructions, which I argue is unexpected under a relative clause analysis that involves operator movement. Instead I present an alternative analysis in which I propose that the referentiality of a noun complement clause is linked to its syntactic behavior. Following recent work, I claim that referential clauses have a syntactically truncated left-periphery, and this truncation can account for the lack of main clause phenomena in noun complement clauses. I argue that the truncation analysis is also able to accommodate complementizer data patterns more easily than relative clause analyses that appeal to operator movement.

  12. Synthesis of N-Mannich bases of berberine linking piperazine moieties revealing anticancer and antioxidant effects

    Directory of Open Access Journals (Sweden)

    Bhupendra Mistry

    2017-01-01

    Full Text Available A new Mannich base series of piperazine linked berberine analogues was furnished in this study to screen the antioxidant and anticancer potential of the resultant analogues. Alkoxy group at a C-9 position of berberine was converted to hydroxyl functionality to enhance the ability of final scaffolds binding to the target of drug action mainly through hydrophobic effect, conjugation effect, whereas Mannich base functionality was introduced on the C-12 position of berberine. Scaffolds were investigated for their free radical scavenging antioxidant potential in FRAP and DPPH assay, whereas tested to check their Fe+3 reducing power in ABTS assay. The radical scavenging potential of the final derivatives 4a–j was found excellent with IC50s, 30 of therapeutic indices, thus exerting low cytotoxic values against Malin–Darby canine kidney (MDCK cell lines at CC50s >125 μg/mL. Hence, from the bioassay outcomes it can be stated that these analogues are dual active agents as the scavengers of reactive oxygen species and inhibitors of the cancerous cells as compounds with halogen functional group have overall good pharmacological potential in assays studied in this research. Correct structure of the final compounds was adequately confirmed on the basis of FT-IR and 1H NMR as well as elemental analyses.

  13. Synthesis of kaempferide Mannich base derivatives and their antiproliferative activity on three human cancer cell lines.

    Science.gov (United States)

    Nguyen, Van-Son; Shi, Ling; Luan, Fang-Qian; Wang, Qiu-An

    2015-01-01

    Kaempferide (3,5,7-trihydroxy-4'-methoxyflavone, 1), a naturally occurring flavonoid with potent anticancer activity in a number of human tumour cell lines, was first semisynthesized from naringin. Based on Mannich reaction of kaempferide with various secondary amines and formaldehyde, nine novel kaempferide Mannich base derivatives 2-10 were synthesized. The aminomethylation occurred preferentially in the position at C-6 and C-8 of the A-ring of kaempferide. All the synthetic compounds were tested for antiproliferative activity against three human cancer cell lines (Hela, HCC1954, SK-OV-3) by the standard MTT method. The results showed that compounds 1, 2 and 5-10 were more potent against Hela cells with IC50 values of 12.47-28.24 μM than the positive control cis-platin (IC50 41.25 μM), compounds 5, 6, 8 and 10 were more potent against HCC1954 cells with IC50 values of 8.82-14.97 μM than the positive control cis-platin (IC50 29.68 μM), and compounds 2, 3, 5, 6 and 10 were more potent against SK-OV-3 cells with IC50 values of 7.67-18.50 μM than the positive control cis-platin (IC50 21.27 μM).

  14. MD5算法研究%MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    张裔智; 赵毅; 汤小斌

    2008-01-01

    随着网络技术的迅速发展,信息加密技术已成为保障网络安全的一种重要手段,加密算法已经成为人们的一个研究热点.本文对MD5算法进行了深入研究,介绍MD5算法的产生背景、应用及其算法流程,并提出了MD5算法的一个改进方案.

  15. 48 CFR 246.710 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 246.710 Contract clauses. (1) Use a... Construction (Germany), instead of the clause at FAR 52.246-21, Warranty of Construction, in solicitations and... Germany....

  16. 48 CFR 3.1004 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Contractor Code of Business Ethics and Conduct 3.1004 Contract clauses. (a) Insert the clause at FAR 52.203-13, Contractor Code of Business Ethics and...

  17. Solving non-linear Horn clauses using a linear Horn clause solver

    DEFF Research Database (Denmark)

    Kafle, Bishoksan; Gallagher, John Patrick; Ganty, Pierre

    2016-01-01

    In this paper we show that checking satisfiability of a set of non-linear Horn clauses (also called a non-linear Horn clause program) can be achieved using a solver for linear Horn clauses. We achieve this by interleaving a program transformation with a satisfiability checker for linear Horn...... clauses (also called a solver for linear Horn clauses). The program transformation is based on the notion of tree dimension, which we apply to a set of non-linear clauses, yielding a set whose derivation trees have bounded dimension. Such a set of clauses can be linearised. The main algorithm...

  18. 48 CFR 819.709 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 819.709 Contract clause. The contracting officer shall insert VAAR clause 852.219-9, Small Business Subcontracting Plan Minimum Requirements, in solicitations and contracts that include FAR clause 52.219-9, Small Business...

  19. 48 CFR 302.201 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... Section 302.201 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL DEFINITIONS OF WORDS AND TERMS Definitions Clause 302.201 Contract clause. The Contracting Officer shall insert the clause in FAR 52.202-1, Definitions, in solicitations and contracts, except as cited below. This is...

  20. 48 CFR 203.1004 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... OF DEFENSE GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Contractor Code of Business Ethics and Conduct 203.1004 Contract clauses. (a) Use the clause at 252.203-7003 in solicitations and contracts that include the FAR clause 52.203-13, Contractor Code of Business Ethics and...

  1. 22 CFR 145.48 - Contract clauses.

    Science.gov (United States)

    2010-04-01

    ... breaches the contract terms, and provide for such remedial actions as may be appropriate. (b) All contracts... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Contract clauses. 145.48 Section 145.48 Foreign... Contract clauses. The recipient shall include, in addition to clauses to define a sound and...

  2. Constraint Specialisation in Horn Clause Verification

    DEFF Research Database (Denmark)

    Kafle, Bishoksan; Gallagher, John Patrick

    2015-01-01

    We present a method for specialising the constraints in constrained Horn clauses with respect to a goal. We use abstract interpretation to compute a model of a query-answer transformation of a given set of clauses and a goal. The effect is to propagate the constraints from the goal top......-down and propagate answer constraints bottom-up. Our approach does not unfold the clauses at all; we use the constraints from the model to compute a specialised version of each clause in the program. The approach is independent of the abstract domain and the constraints theory underlying the clauses. Experimental...

  3. Relative Clauses in Classical Nahuatl

    Science.gov (United States)

    Langacker, Ronald W.

    1975-01-01

    Jane Rosenthal's paper on relative clauses in Classical Nahuatl is discussed, and it is argued that she misses an important generalization. An alternative analysis to a class of relative pronouns and new rules for the distribution of relative pronouns are proposed. (SC)

  4. Synthesis of some derivatives of compounds β-aminoketonic through Mannich reaction by usingbiocatalysts

    Directory of Open Access Journals (Sweden)

    Ana Claudia S. Lima

    2012-06-01

    Full Text Available The Mannich reaction is one of the most widely used reactions in organic chemistry, and also one of the first examples of a multicomponent reaction already described on the literature. This reaction results in β-aminocarbonylated compounds which allow the generation of several structures that can be used in the synthesis of both biologically active molecules, and natural products, however, just a few synthetic routes resulting in the formation of β-aminocarbonylated compound are known. In this sense, new methodologies have been developed by involving new catalysts or chiral auxiliaries in the synthesis of β-aminocarbonylated compounds with biological activity. One of these methodologies is the biocatalysis, which is a technique that uses biological catalysts, like enzymes or micro-organisms to convert a substrate in a limited number of enzymatic steps. The use of micro-organisms, plants or isolated enzymes as chiral catalysts has proportioned a significant advance in the synthetic chemistry, because it is known that the biocatalysts have selective catalytic sites that afford the formation of enantiomerically pure products and which is extremely important, because it is known that differences of the chirality may have tragic or spectacular effects in humans. Concerning to the environmental issue, the biocatalysis is placed within the context of a new philosophy called Green Chemistry. However, in the State of Mato Grosso do Sul the researches involving this issue of biocatalysis are still incipient once that by the year of 2010 there was only one research group focused on this themeregistered in the Lattes Platform in the State. Because of the need of support to the researches focused on this issue in the State of Mato Grosso do Sul and to evaluate thebiocatalytic potential of different lineage of microorganisms and enzymes in the synthesis of compounds β-aminoketonic through Mannich reaction it was proposed the use of someenzymes such as

  5. Synthesis and Biological Activity of 1,3,4-Oxadiazole Mannich Bases Containing Pyrimidine Rings%含嘧啶环的1,3,4-噁二唑 Mannich 碱的合成及生物活性

    Institute of Scientific and Technical Information of China (English)

    沈生强; 孙晓红; 刘源发; 陈邦; 靳如意; 马海霞

    2014-01-01

    1,3,4-Oxadiazole derivatives were reported to possess a broad spectrum of biological activities, such as antifungal, antibacterial, antiviral and antitubercular. Mannich bases had also been reported as poten-tial biological agents, they were applicated in the fields of synthetic study and medicinal chemistry. In recent years, Mannich bases containing 1,3,4-oxadiazole ring had attracted a lot of attention and many Mannich ba-ses of 1,3,4-oxadiazole bearing heterocycle scaffold were reported to have special bioactivity. Nevertheless, literature revealed that there were no reports of a molecular scaffold that Mannich base of 1,3,4-oxadiazole bearing pyrimidine. Prompted by these observations, a series of 1,3,4-oxadiazole derivatives containing py-rimidine( E1-E15) was synthesized from 5-aryl-1,3,4-oxadiazole-2-thione ( C1-C3), formaldehyde and substituted aminopyrimidine ( D1-D5) by Mannich reaction. 5-Aryl-1,3,4-oxadiazole-2-thione derivatives (C1-C3) were prepared from aromatic acids as the starting material via esterification, hydrazinolysis and cy-clization. The structures of all title compounds were confirmed by elemental analysis, IR, 1 H NMR tech-niques. Furthermore, their biological activities to four vegetable pathogens containing Gibberll nicotiancola, Gibberlla saubinetii, Fusarium oxysporium f. sp. niveum, Pythium solani had been tested. The preliminary re-sults indicated that most of the compounds exhibit relatively good fungicidal activities, especially compounds E3 and E8 showed better biological activity than triazolone.%以芳香酸为原料,通过酯化、肼解及环化反应制得中间体5-芳基取代-1,3,4-噁二唑-2-硫酮(C1~C3),然后中间体与甲醛和取代氨基嘧啶(D1~ D5)发生 Mannich 反应得到一系列新型含有嘧啶环的1,3,4-噁二唑类衍生物(E1~ E15)。所得目标化合物的结构经元素分析、 IR 及1 H NMR 确认。初步的生物活性测定结果表明,大部分目标化合物对植物病原菌有很好

  6. Topic extraction from adverbial clauses

    Directory of Open Access Journals (Sweden)

    Carlos Rubio Alcalá

    2016-06-01

    Full Text Available This paper offers new data to support findings about Topic extraction from adverbial clauses. Since such clauses are strong islands, they should not allow extraction of any kind, but we show here that if the appropriate conditions are met, Topics of the CLLD kind in Romance can move out of them. We propose that two conditions must be met for such movement to be possible: the first is that the adverbial clause must have undergone topicalisation in the first place; the second is that the adverbial clause is inherently topical from a semantic viewpoint. Contrast with other language families (Germanic, Quechua and Japanese is provided and the semantic implications of the proposal are briefly discussed. Keywords: topicalisation; Clitic Left Dislocation; syntactic islands; adverbial clauses Este artículo ofrece nuevos datos sobre la extracción de Tópicos desde oraciones subordinadas adverbiales. Dado que dichas oraciones son islas fuertes, no deberían permitir extracción de ningún tipo, pero mostramos que si se dan las condiciones apropiadas, los Tópicos del tipo CLLD en lenguas románicas pueden desplazarse fuera de ellas. Proponemos que se deben cumplir dos condiciones para que ese movimiento sea posible: la primera es que la propia subordinada adverbial se haya topicalizado en primer lugar; la segunda es que la subordinada adverbial sea inherentemente un Tópico desde el punto de vista semántico. Proporcionamos también algunos contrastes con otras familias lingüísticas (germánica, quechua y japonés y se discuten brevemente las implicaciones semánticas de la propuesta. Palabras clave: topicalización; dislocación a la izquierda con clítico; islas sintácticas; oraciones adverbiales

  7. 78 FR 14547 - Praxedes E. Alverez Santiago, M.D., Daniel Perez Brisebois, M.D., Jorge Grillasca Palou, M.D...

    Science.gov (United States)

    2013-03-06

    ... Praxedes E. Alverez Santiago, M.D., Daniel Perez Brisebois, M.D., Jorge Grillasca Palou, M.D., Rafael Garcia Nieves, M.D., Francis M. Vazques Roura, M.D., Angel B. Rivera Santos, M.D., Cosme D. Santos Torres, M.D., and Juan L. Vilaro Chardon, M.D.; Analysis of Agreement Containing Consent Order To Aid...

  8. Synthesis, antiproliferative and antimicrobial activity of new Mannich bases bearing 1,2,4-triazole moiety.

    Science.gov (United States)

    Popiołek, Łukasz; Rzymowska, Jolanta; Kosikowska, Urszula; Hordyjewska, Anna; Wujec, Monika; Malm, Anna

    2014-12-01

    Abstract This study presents the synthesis, antiproliferative and antimicrobial evaluation of a new series of Mannich base derivatives containing 1,2,4-triazole system. New compounds were prepared by the reaction of 4,5-disubstituted 1,2,4-triazole-3-thiones with formaldehyde and various amines. The structures of the prepared compounds were confirmed by means of (1)H NMR, (13)C NMR and elemental analyses. Twelve compounds were evaluated for their in vitro antiproliferative activities against six chosen cancer cell lines. All synthesized compounds were screened for their in vitro antimicrobial activity by using the agar dilution technique. For 17 potentially active compounds, their antibacterial activity was confirmed on the basis of MIC (minimal inhibitory concentration) by broth microdilution method using the reference Gram-positive and Gram-negative bacterial strains.

  9. Synthesis and Biological Evaluation of Mannich Bases of Isoxazoline Derivatives as Novel Anti-Microbial Agents

    Directory of Open Access Journals (Sweden)

    Pawar Sudhir

    2012-01-01

    Full Text Available A novel series of compounds were synthesized by condensation reaction of substituted acetophenone (1a-b with substituted aldehyde (2a-b in presence of alcoholic sodium hydroxide to get intermediate chalcones (3a-c, which were further treated with hydroxylamine hydrochloride in presence of sodium hydroxide to get isoxazolines derivatives (4a-c. The latter were refluxed with substituted primary amines and formaldehyde for 6-10 h to afford Mannich bases. The synthesized compounds were characterized on the basis of their spectral (IR, 1HNMR data and evaluated for the antimicrobial activity by using Zone of Inhibition by cup plate method and Minimum Inhibitory Concentration by broth dilution method.

  10. A new Mannich base and its transition metal (II) complexes - Synthesis, structural characterization and electrochemical study

    Indian Academy of Sciences (India)

    N Raman; S Esthar; C Thangaraja

    2004-06-01

    new Mannich base, N-(1-morpholinobenzyl) semicarbazide (MBS), formed by the condensation of morpholine, semicarbazide and benzaldehyde, and its Cu(II), Ni(II), Co(II) and Zn(II) complexes have been synthesized. Their structures have been elucidated on the basis of analytical, magnetic, electrical conductivity and spectral study as well as elemental analyses. The complexes exhibit square-planar geometry. The monomeric and non-electrolytic nature of the complexes is evidenced by their magnetic susceptibility and low conductance data. The electrochemical property of the ligand and its complexes in acetonitrile solution was studied by cyclic voltammetry. The X-band ESR spectra of the Cu(II) complex in DMSO at 300 and 77 K were recorded and their salient features are reported.

  11. Stereoselectivities in α- and β-Amino Acids Catalyzed Mannich Reactions Involving Cyclohexanone

    Institute of Scientific and Technical Information of China (English)

    WANG Ying; FU Ai-ping; LI Hong-liang; TIAN Feng-hui; YUAN Shu-ping; SI Hong-zong; DUAN Yun-bo; WANG Zong-hua

    2011-01-01

    The effects of two different amino acid catalysts on the stereoselectivities in the direct Mannich reactions of cyclohexanone,p-anisidine and p-nitrobenzaldehyde were studied with the aid of density functional theory.Transition states of the stereo-determining C-C bond-forming step with the addition of enamine intermediate to the imine for the L-proline(α-amino acid) and (R)-3-pyrrolidinecarboxylic acid(β-amino acid)-catalyzed processes were reported.B3LYP/6-31G** calculations provide a good explanation for the opposite syn vs.anti diastereoselectivities of these two different kinds of catalysts(syn-selectivity for the α-amino acid catalysts,anti-selectivity for the β-amino acid catalysts).Calculated and observed diastereomeric ratio and enantiomeric excess values are in reasonable agreement.

  12. Facile synthesis and stereochemical investigation of Mannich base derivatives: evaluation of antioxidant property and antituberculostic potency.

    Science.gov (United States)

    Parthiban, Paramasivam; Subalakshmi, Viswalingam; Balasubramanian, Krishnamurthy; Islam, Md Nurul; Choi, Jae Sue; Jeong, Yeon Tae

    2011-04-15

    A mini-library of diversely substituted 2,4-diaryl-3-azabicyco[3.3.1]nonan-9-one O-methyloximes and their N-methyl analogs were synthesized by a non-laborious, modified and an optimized Mannich condensation in good yields. Both the ring N-methylation and oxime O-methylation were employed by various methods; of them, the usage of (t)BuOK was found to be the superior in terms of good yield in short time. Stereochemistry of all the synthesized compounds was unambiguously established by their NMR spectral ((1)H, (13)C, (1)H-(1)H COSY, (1)H-(13)C one and multiple bond COSY and NOESY) as well as single-crystal XRD studies. Irrespective of the nature and position of the substituents, all the synthesized oxime ethers of the bicyclic Mannich bases as well as their N-methyl analogs adopted the twin-chair conformation with equatorial orientations of all the substituents. All the synthesized oxime ethers were evaluated for their antioxidant property by DPPH radical scavenging method. According to the structure-activity correlations, compound 4y was found to be a lead molecule with the IC(50) of 0.187 mg/mL. Thus, the present study exploits the scope of finding more active analogs by further optimization with the incorporation of more electron enriched alkoxy/amino and/or phenolic groups on the heterocycle as well as oxime ether pharmacophore. Most of the synthesized molecules were screened for their antituberculostic potency against Mycobacterium tuberculosis H(37)Rv by zone of inhibition method. Of them, 4w/5d and 4x showed very promising inhibition zones of 21 and 23 mm, respectively, which leads to the optimization of 4x by introducing various substituents on the O-benzyl moiety to enhance the antituberculostic potency.

  13. Inhibition of Mild Steel Corrosion in 1M H2SO4 Medium by Benzimidazole Mannich bases

    Directory of Open Access Journals (Sweden)

    P. M. Dasami

    2015-03-01

    Full Text Available The corrosion inhibition behaviour of two synthesized Mannich bases has been investigated for mild steel in 1M H2SO4 by weight loss and electrochemical techniques.The inhibition efficiency depends on concentration of the inhibitor and temperature. The inhibitors function by adsorption on mild steel surface and obey Langmuir isotherm indicating monolayer adsorption on the surface. Thermodynamic parameters show that the adsorption of the inhibitors occurs through electrostatic interaction. Polarization studies reveal that the inhibitors behave as mixed type in 1M H2SO4 affecting both anodic metal dissolution and cathodic hydrogen evolution. SEM studies show the formation of surface adsorptive film of the Mannich bases on the mild steel surface.

  14. Synthesis of the reported structure of piperazirum using a nitro-Mannich reaction as the key stereochemical determining step

    Directory of Open Access Journals (Sweden)

    James C. Anderson

    2013-08-01

    Full Text Available Piperazirum, isolated from Arum palaestinum Boiss, was originally assigned as r-3,c-5-diisobutyl-c-6-isopropylpiperazin-2-one. The reported structure was synthesised diastereoselectively using a key nitro-Mannich reaction to set up the C5/C6 relative stereochemistry. The structure was unambiguously assigned by single crystal X-ray diffraction but the spectroscopic data did not match those reported for the natural product. The structure of the natural product must therefore be revised.

  15. SYNTHESIS OF BIS-PYRIMIDO IMIDAZOLE FUSED RING HETEROCYCLIC ADDUCT WITH UREAS OF MANNICH BASE FOR CNS DEPRESSION

    Directory of Open Access Journals (Sweden)

    AVANI H. SHETH*, PARIMAL M. PRAJAPATI, YATRI R. SHAH AND DHRUBO JYOTI SEN

    2009-12-01

    Full Text Available Mannich bases as well as urea derivatives have potent CNS depression activity. In our project work we have chosen aCNS drug which blocks the GABA receptor as well as chloride channel. Benzodiazepines have closed chain amidelinkage which acts on GABA (gamma amino butyric acid receptor and produces CNS depression with the blockageof chloride channel. This receptor has free amino and carboxylic acid functional group which produces amide linkagein-vivo.

  16. Accurate Reaction Enthalpies and Sources of Error in DFT Thermochemistry for Aldol, Mannich, and α-Aminoxylation Reactions

    Science.gov (United States)

    Wheeler, Steven E.; Moran, Antonio; Pieniazek, Susan N.; Houk, K. N.

    2009-08-01

    Enthalpies for bond-forming reactions that are subject to organocatalysis have been predicted using the high-accuracy CBS-QB3 model chemistry and six DFT functionals. Reaction enthalpies were decomposed into contributions from changes in bonding and other intramolecular effects via the hierarchy of homodesmotic reactions. The order of the reaction exothermicities (aldol < Mannich ≈ α-aminoxylation) arises primarily from changes in formal bond types mediated by contributions from secondary intramolecular interactions. In each of these reaction types, methyl substitution at the β- and γ-positions stabilizes the products relative to the unsubstituted case. The performance of six DFT functionals (B3LYP, B3PW91, B1B95, MPW1PW91, PBE1PBE, and M06-2X), MP2, and SCS-MP2 has been assessed for the prediction of these reaction enthalpies. Even though the PBE1PBE and M06-2X functionals perform well for the aldol and Mannich reactions, errors roughly double when these functionals are applied to the α-aminoxylation reactions. B3PW91 and B1B95, which offer modest accuracy for the aldol and Mannich reactions, yield reliable predictions for the two α-aminoxylation reactions. The excellent performance of the M06-2X and PBE1PBE functionals for aldol and Mannich reactions stems from the cancellation of sizable errors arising from inadequate descriptions of the underlying bond transformations and intramolecular interactions. SCS-MP2/cc-pVTZ performs most consistently across these three classes of reactions, although the reaction exothermicities are systematically underestimated by 1-3 kcal mol-1. Conventional MP2, when paired with the cc-pVTZ basis set, performs somewhat better than SCS-MP2 for some of these reactions, particularly the α-aminoxylations. Finally, the merits of benchmarking DFT functionals for the set of simple chemically meaningful transformations underlying all bond-forming reactions are discussed.

  17. 21 CFR 26.21 - Safeguard clause.

    Science.gov (United States)

    2010-04-01

    ... OF PHARMACEUTICAL GOOD MANUFACTURING PRACTICE REPORTS, MEDICAL DEVICE QUALITY SYSTEM AUDIT REPORTS... Specific Sector Provisions for Pharmaceutical Good Manufacturing Practices § 26.21 Safeguard clause....

  18. The Thematic Structure of Chinese Clause

    Institute of Scientific and Technical Information of China (English)

    马晓斐

    2013-01-01

    At the beginning of this essay, let me explore what is clause. Clause is elements that has no verb structure, but it con⁃tains the subject-predicate relationship. Clause is the supreme unit in grammar, and it is the starting point of systems such as tran⁃sitivity, mood and theme. It reflects the experiential meaning, interpersonal meaning and textual meaning. For example, in the sen⁃tence "In the summer vacation, I'll go to see my grandparents." is a clause.

  19. RELATIVE CLAUSES FROM ENGLISH TO ALBANIAN

    Directory of Open Access Journals (Sweden)

    Suela Koça

    2016-09-01

    Full Text Available This paper aims to describe the use of relative clauses in English and Albanian by comparing different clause types. Some theoretical issues addressed in this article include the definition of relative clauses, the relativized elements, and the use of relative pronouns and adverbs in both languages. Distinctions and similarities are identified by analyzing the way in which these clauses are translated from English into Albanian. The theoretical part is illustrated by examples extracted from “Animal Farm” by George Orwell and “Pride and Prejudice” by Jane Austin, and their translated versions in Albanian, “Ferma e Kafshëve” and “Krenari dhe Paragjykime”.

  20. Santa Claus ’Names

    Institute of Scientific and Technical Information of China (English)

    寒冰

    2005-01-01

    A ustria—Christkind Belgium and the N etherlands—N oel Saint Nicholas C hristkind and Black Pete Brazil—Papa;N oel D enm ark—Julinisse England—Father Christm as Finland—O ld M an C hristm asFrance—Pere N oel or le Petit Germ any—K riss Kringle Christkind or Saint N icholas Italy—B efana Japan—Santa K urohsu M exico—Three Kings Poland—Star M an or W ise M en Spain—Three Kings R ussia—B asbouschka ?Santa Claus ’Names@寒冰

  1. Solving non-linear Horn clauses using a linear Horn clause solver

    DEFF Research Database (Denmark)

    Kafle, Bishoksan; Gallagher, John Patrick; Ganty, Pierre

    2016-01-01

    In this paper we show that checking satisfiability of a set of non-linear Horn clauses (also called a non-linear Horn clause program) can be achieved using a solver for linear Horn clauses. We achieve this by interleaving a program transformation with a satisfiability checker for linear Horn...... clauses (also called a solver for linear Horn clauses). The program transformation is based on the notion of tree dimension, which we apply to a set of non-linear clauses, yielding a set whose derivation trees have bounded dimension. Such a set of clauses can be linearised. The main algorithm...... dimension. We constructed a prototype implementation of this approach and performed some experiments on a set of verification problems, which shows some promise....

  2. 48 CFR 2446.710 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... Performance Specifications or Design Criteria, whenever it is in the Government's interest. ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clauses. 2446.710... CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 2446.710 Contract clauses. (c)(1) The contracting...

  3. 48 CFR 225.7503 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Balance of Payments Program 225.7503 Contract clauses. Unless the entire acquisition is exempt from the Balance of Payments Program— (a) Use the clause at 252.225-7044, Balance of Payments Program—Construction Material, in solicitations and...

  4. 48 CFR 3017.9000 - Clauses (USCG).

    Science.gov (United States)

    2010-10-01

    ... officer may, in whole or in part (such as after incidents), increase the dollar amounts in the clause at (HSAR) 48 CFR 3052.217-95(b)(6) and (c)(1) consistent with contract size, inflation, and other... dollar amounts in the clause at (HSAR) 48 CFR 3052.217-95(b)(6) and (c)(1) consistent with contract...

  5. On degree phrases and result clauses

    NARCIS (Netherlands)

    Rijkhoek, Paulien Dea

    1998-01-01

    This dissertation consists of two parts, one on degree phrases and one on result clauses. Sentence (1) below exemplifies a result clause construction: (1) Zij had zo mooi gezongen dat het publiek er stil van was she has so beautifully sang that the audience there silent of was ‘She had sung so beaut

  6. MD 751: Train Instability Threshold

    CERN Document Server

    Carver, Lee Robert; Metral, Elias; Salvant, Benoit; Levens, Tom; Nisbet, David; Zobov, M; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the octupole current thresholds for stability for a single bunch, and then make an immediate comparison (with the same operational settings) for a train of 72 bunches separated by 25ns. From theory, the expected thresholds should be similar. Any discrepancy between the two cases will be of great interest as it could indicate the presence of additional mechanisms that contribute to the instability threshold, for example electron cloud.

  7. Sulphur condensation influence in Claus catalyst performance.

    Science.gov (United States)

    Mora, R L

    2000-12-01

    The Claus process is an efficient way of removing H(2)S from acid gas streams and this is widely practised in industries such as natural gas processing, oil refining and metal smelting. Increasingly strict pollution control regulations require maximum sulphur recovery from the Claus unit in order to minimise sulphur-containing effluent. The most widely used Claus catalyst in sulphur recovery units is non-promoted spherical activated alumina. Properties associated with optimum non-promoted Claus catalyst performance include high surface area, appropriate pore size distribution and enhanced physical properties. The objective of this paper is to outline a procedure in order to estimate Claus catalyst effectiveness after pore plugging due to sulphur condensation. Catalyst deactivation due to pore plugging by sulphur is modelled employing a Bethe lattice and its corresponding performance is described by means of a modified effectiveness factor. Model results show an improvement in the modified effectiveness factor due to modifications in catalyst porous structure.

  8. Synthesis and Biological Evaluation of New Eugenol Mannich Bases as Promising Antifungal Agents.

    Science.gov (United States)

    Abrão, Pedro Henrique O; Pizi, Rafael B; de Souza, Thiago B; Silva, Naiara C; Fregnan, Antonio M; Silva, Fernanda N; Coelho, Luiz Felipe L; Malaquias, Luiz Cosme C; Dias, Amanda Latercia T; Dias, Danielle F; Veloso, Marcia P; Carvalho, Diogo T

    2015-10-01

    New Mannich base-type eugenol derivatives were synthesized and evaluated for their anticandidal activity using a broth microdilution assay. Among the synthesized compounds, 4-allyl-2-methoxy-6-(morpholin-4-ylmethyl) phenyl benzoate (7) and 4-{5-allyl-2-[(4-chlorobenzoyl)oxy]-3-methoxybenzyl}morpholin-4-ium chloride (8) were found to be the most effective antifungal compounds with low IC50 values, some of them well below those of reference drug fluconazole. The most significant IC50 values were those of 7 against C. glabrata (1.23 μm), C. albicans and C. krusei (both 0.63 μm). Additionally, the synthesized compounds were evaluated for their in vitro cytotoxic effects on human mononuclear cells. As result, the cytotoxic activity of eugenol in eukaryotic cells decreased with the introduction of the morpholinyl group. Given these findings, we point out compounds 7 and 8 as the most promising derivatives because they showed potency values greater than those of eugenol and fluconazole and they also presented high selectivity indexes.

  9. Design, synthesis, characterization, and computational studies on benzamide substituted Mannich bases as novel, potential antibacterial agents.

    Science.gov (United States)

    Bala, Suman; Sharma, Neha; Kajal, Anu; Kamboj, Sunil

    2014-01-01

    A series of benzamide substituted Mannich bases (1-7) were synthesized. The synthesized derivatives were authenticated by TLC, UV-Visible, FTIR, NMR, and mass spectroscopic techniques and further screened for in vitro antibacterial activity by test tube dilution method using amoxicillin and cefixime as standard drugs. The compounds 5, 6, and 7 were found to be the most active antibacterial agents among all the synthesized compounds. The physicochemical similarity of the compounds with standard drugs was assessed by calculating various physicochemical properties using software programs. The percent similarity of synthesized compounds was found to be good and compound 1 was found to have higher percentage of similarity. The compounds were subjected to QSAR by multilinear regression using Analyze it version 3.0 software, and four statistically sound models were developed with R2 (0.963-0.997), Radj2 (0.529-0.982), and Q2 (0.998-0.999) with good F (2.35-65.56) values.

  10. Mechanistic implications in the phosphatase activity of Mannich-based dinuclear zinc complexes with theoretical modeling.

    Science.gov (United States)

    Sanyal, Ria; Zhang, Xuepeng; Kundu, Priyanka; Chattopadhyay, Tanmay; Zhao, Cunyuan; Mautner, Franz A; Das, Debasis

    2015-03-02

    An "end-off" compartmental ligand has been synthesized by an abnormal Mannich reaction, namely, 2-[bis(2-methoxyethyl)aminomethyl]-4-isopropylphenol yielding three centrosymmetric binuclear μ-phenoxozinc(II) complexes having the molecular formula [Zn2(L)2X2] (Zn-1, Zn-2, and Zn-3), where X = Cl(-), Br (-), and I (-), respectively. X-ray crystallographic analysis shows that the ZnO3NX chromophores in each molecule form a slightly distorted trigonal-bipyramidal geometry (τ = 0.55-0.68) with an intermetallic distance of 3.068, 3.101, and 3.083 Å (1-3, respectively). The spectrophotometrical investigation on their phosphatase activity established that all three of them possess significant hydrolytic efficiency. Michaelis-Menten-derived kinetic parameters indicate that the competitiveness of the rate of P-O bond fission employing the phosphomonoester (4-nitrophenyl)phosphate in 97.5% N,N-dimethylformamide is 3 > 1 > 2 and the kcat value lies in the range 9.47-11.62 s(-1) at 298 K. Theoretical calculations involving three major active catalyst forms, such as the dimer-cis form (D-Cis), the dimer-trans form (D-Trans), and the monoform (M-1 and M-2), systematically interpret the reaction mechanism wherein the dimer-cis form with the binuclear-bridged hydroxide ion acting as the nucleophile and one water molecule playing a role in stabilizing the leaving group competes as the most favored pathway.

  11. 76 FR 53346 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Science.gov (United States)

    2011-08-26

    ... Model DC-9-81 (MD- 81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87), and MD-88 Airplanes AGENCY... Jersey Avenue, SE., Washington, DC 20590. Hand Delivery: Deliver to Mail address above between 9 a.m. and...) This AD applies to The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD-83),...

  12. 76 FR 41651 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Science.gov (United States)

    2011-07-15

    ... Model DC-9-81 (MD- 81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87), and MD-88 Airplanes AGENCY... Ground Floor, Room W12-140, 1200 New Jersey Avenue, SE., Washington, DC 20590. FOR FURTHER INFORMATION...) This AD applies to The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD-83),...

  13. 48 CFR 970.3270 - Standard financial management clauses.

    Science.gov (United States)

    2010-10-01

    ... Standard financial management clauses. (a) The following DEAR and FAR clauses are standard financial... Accounting Standards. (b) The following DEAR clauses are standard financial management clauses. The... systems: (1) 970.5232-7, Financial management system. (2) 970.5232-8, Integrated accounting. (c)...

  14. A tandem Mannich addition–palladium catalyzed ring-closing route toward 4-substituted-3(2H-furanones

    Directory of Open Access Journals (Sweden)

    Jubi John

    2014-06-01

    Full Text Available A facile route towards highly functionalized 3(2H-furanones via a sequential Mannich addition–palladium catalyzed ring closing has been elaborated. The reaction of 4-chloroacetoacetate esters with imines derived from aliphatic and aromatic aldehydes under palladium catalysis afforded 4-substituted furanones in good to excellent yields. 4-Hydrazino-3(2H-furanones could also be synthesized from diazo esters in excellent yields by utilising the developed strategy. We could also efficiently transform the substituted furanones to aza-prostaglandin analogues.

  15. Rh-Catalyzed reductive Mannich-type reaction and its application towards the synthesis of (±)-ezetimibe

    Science.gov (United States)

    Isoda, Motoyuki; Sato, Kazuyuki; Kunugi, Yurika; Tokonishi, Satsuki; Tarui, Atsushi; Minami, Hideki

    2016-01-01

    Summary An effective synthesis for syn-β-lactams was achieved using a Rh-catalyzed reductive Mannich-type reaction. A rhodium–hydride complex (Rh–H) derived from diethylzinc (Et2Zn) and a Rh catalyst was used for the 1,4-reduction of an α,β-unsaturated ester to give a Reformatsky-type reagent, which in turn, reacted with an imine to give the syn-β-lactam. Additionally, the reaction was applied to the synthesis of (±)-ezetimibe, a potent β-lactamic cholesterol absorption inhibitor. PMID:27559413

  16. 48 CFR 416.670 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... CONTRACT TYPES TYPES OF CONTRACTS Time-and-Materials, Labor-Hour, and Letter Contracts 416.670 Contract clauses. The contracting officer shall limit the Government's obligation under a time-and-materials...

  17. PENALTY CLAUSES WITHIN DIFFERENT LEGAL SYSTEMS

    Directory of Open Access Journals (Sweden)

    Simas Vitkus

    2013-06-01

    Full Text Available In this article the regulation in regard of penalty clauses within two different legal traditions, i.e. common law tradition and continental law tradition, is analyzed. In general a penalty clause implies a fixed sum, which has to be paid by a party for the failure to perform its contractual duties timely and duly. In common law world penalty clauses are rendered unenforceable, whereas civil law countries, including the Republic of Lithuania, consider such clauses enforceable to the extent that the stipulated amount is not excessive. Moreover, in the article attempts to reach a uniform regulation throughout various legal instruments are revealed. Purpose: to analyze the regulation of penalty clauses within different legal systems. Methodology: a systematic method was used in order to ascertain the content and true meaning of the legislation concerning penalty clauses, whereas comparative method allowed comparing such legislation among different jurisdictions. On the basis of analytical method conclusions were withdrawn. Findings: common law courts on the basis of just compensation principle may declare a clause, which stands for a penalty, unenforceable, whereas civil law courts may only reduce grossly excessive amount. However, under major soft law instruments, such as the UNIDROIT Principles , PECL and DCRF , the divergence from common law rules of non-enforcement of penalty clauses is evident. Although there is a lack of binding transnational rules that control the enforceability of penalty clauses across the countries, it seems that today the most feasible solution consists of the approval of national rules, which would shield the enforcement of penalties in international commercial contracts in common law jurisdictions. Research limitations: in the light of the civil law system terms of liquidated damages and penalty clause are used interchangeably, since both are enforceable. However, a distinction between the two can be made on the basis

  18. 48 CFR 2439.107 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... contracting officer shall insert the clause at 48 CFR 2452.239-71, Information Technology Virus Security, in solicitations and contracts under which the contractor will provide information technology hardware, software or data products....

  19. Clause Elimination Procedures for CNF Formulas

    Science.gov (United States)

    Heule, Marijn; Järvisalo, Matti; Biere, Armin

    We develop and analyze clause elimination procedures, a specific family of simplification techniques for conjunctive normal form (CNF) formulas. Extending known procedures such as tautology, subsumption, and blocked clause elimination, we introduce novel elimination procedures based on hidden and asymmetric variants of these techniques. We analyze the resulting nine (including five new) clause elimination procedures from various perspectives: size reduction, BCP-preservance, confluence, and logical equivalence. For the variants not preserving logical equivalence, we show how to reconstruct solutions to original CNFs from satisfying assignments to simplified CNFs. We also identify a clause elimination procedure that does a transitive reduction of the binary implication graph underlying any CNF formula purely on the CNF level.

  20. 76 FR 39251 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Science.gov (United States)

    2011-07-06

    ... Model DC-9-81 (MD- 81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87), and MD-88 Airplanes AGENCY... Jersey Avenue, SE., Washington, DC 20590. FOR FURTHER INFORMATION CONTACT: Roger Durbin, Aerospace.... Applicability (c) This AD applies to all The Boeing Company Model DC-9-81 (MD- 81), DC-9-82 (MD-82), DC-9-83...

  1. 76 FR 1993 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Science.gov (United States)

    2011-01-12

    ... Model DC-9-81 (MD- 81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87), and MD-88 Airplanes AGENCY... Ground Floor, Room W12-140, 1200 New Jersey Avenue, SE., Washington, DC 20590. FOR FURTHER INFORMATION.... Applicability (c) This AD applies to The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83...

  2. 76 FR 13543 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Science.gov (United States)

    2011-03-14

    ... Model DC-9-81 (MD- 81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87), and MD-88 Airplanes AGENCY... Floor, Room W12-140, 1200 New Jersey Avenue, SE., Washington, DC 20590. Hand Delivery: Deliver to Mail... stabilizer is similar in design and loading to that of the Model DC-9-81 (MD-81), DC- 9-82 (MD-82),...

  3. Agreement and the structure of relative clauses

    Directory of Open Access Journals (Sweden)

    Boban Arsenijević

    2016-07-01

    Full Text Available The paper proposes an account of asymmetries in agreement patterns that obtain in restrictive and non-restrictive relative clauses headed by hybrid agreement nouns 'd(jeca '‘children’, 'braća '‘brothers’, and 'gospoda '‘gentry’ in Bosnian/Croatian/Serbian (BCS. We note that relative clauses headed by hybrid nouns display different possibilities of agreement morphology on the relative pronoun 'koji/a/e '‘which’, depending, on the one hand, on whether the relative clause is restrictive or non-restrictive and on the other, on the case of the relative pronoun. We argue that the observed differences are the result of a conspiracy of the following factors: (i hybrid number-agreement nouns introduce a null plural pronoun unspecified for gender (Postal 1966; den Dikken 2001; Torrego and Laga 2015, (ii all plural case forms of the relative pronoun except for nominative and accusative show full gender syncretism (Alsina and Arsenijević 2012b, and (iii non-restrictive relative clauses involve a null definite pronoun and attach to the head noun higher than the restrictive relative clauses (Postal 1994; de Vries 2002; 2006. We maintain that the facts discussed in the paper argue against analyses which derive the differences between restrictive and non-restrictive relative clauses from their LF representations, rather than from their overt syntax.

  4. Cavity Voltage Phase Modulation MD

    CERN Document Server

    Mastoridis, Themistoklis; Molendijk, John; Timko, Helga; CERN. Geneva. ATS Department

    2016-01-01

    The LHC RF/LLRF system is currently configured for extremely stable RF voltage to minimize transient beam loading effects. The present scheme cannot be extended beyond nominal beam current since the demanded power would exceed the peak klystron power and lead to saturation. A new scheme has therefore been proposed: for beam currents above nominal (and possibly earlier), the cavity phase modulation by the beam will not be corrected (transient beam loading), but the strong RF feedback and One-Turn Delay feedback will still be active for loop and beam stability in physics. To achieve this, the voltage set point will be adapted for each bunch. The goal of this MD was to test a new algorithm that would adjust the voltage set point to achieve the cavity phase modulation that would minimize klystron forward power.

  5. Highly efficient catalytic enantioselective Mannich reaction of malonates with N-tert-butoxycarbonyl imines by using Yb(OTf)3/pybox catalysts at room temperature.

    Science.gov (United States)

    Karimi, Babak; Jafari, Ehsan; Enders, Dieter

    2013-07-29

    Go Mannich! A highly efficient and enantioselective method for the direct asymmetric reaction of dibenzyl malonate with N-tert-butoxycarbonyl aldimines in the presence of Yb(OTf)3 and iPr-pybox complexes is described (see scheme; pybox = pyridine bisoxazoline).

  6. Highly efficient synthesis of β-amino esters via Mannich-type reaction under solvent-free conditions using ZnCl2 catalyst

    Institute of Scientific and Technical Information of China (English)

    Xue Ming Chen; Xing Shu Li; Albert S.C. Chan

    2009-01-01

    β-Amino esters were synthesized via ZnCl2-catalyzed Mannich-type reaction of imines and malonate esters under solvent-free conditions in 6 min.The β-amino ester was converted into the corresponding aspartic acid derivatives.

  7. Synthesis of new 1,2,4-triazole compounds containing Schiff and Mannich bases (morpholine) with antioxidant and antimicrobial activities.

    Science.gov (United States)

    Ünver, Yasemin; Deniz, Sadik; Çelik, Fatih; Akar, Zeynep; Küçük, Murat; Sancak, Kemal

    2016-01-01

    Compound 2 was synthesized by reacting CS2/KOH with compound 1. The treatment of compound 2 with hydrazine hydrate produced compound 3. Then, compound 3 was converted to Schiff bases (4a-d) by the handling with several aromatic aldehydes. The treatment of triazole compounds 4a-d containing Schiff base with morpholine gave compounds 5a-d. All compounds were tested for their antioxidant and antimicrobial activities. The antioxidant test results of DPPH• radical scavenging and ferric reducing/antioxidant power methods showed good antioxidant activity. The triazole-thiol (3) was the most active, and the effect of the substituent type of the thiophene ring on the activity was same for both Schiff bases (4a-d) and Mannich bases (5a-d). Among the newly synthesized triazole derivatives, the Schiff base 4d and the Mannich base 5d carrying nitro substituent on the thiophene ring showed promising antibacterial and antifungal activity, with lower MIC values than the standard antibacterial ampicillin.

  8. A Corpus Analysis of "Would"-Clauses Without Adjacent "If"-Clauses.

    Science.gov (United States)

    Frazier, Stefan

    2003-01-01

    Reports findings of a corpus analysis of a grammatical structure taught in intermediate- or advanced-level English-as-a-Second-/Foreign-Language texts: clauses that contain the modal "would" to signify hypothetical and counterfactual meaning. Categorizes the conditional and hypothetical uses of would-clauses in spoken and written corpora…

  9. Discriminative ability of two different external anchors: improvement appears better than importance

    DEFF Research Database (Denmark)

    Lauridsen, Henrik Hein

    2009-01-01

    Title:    Discriminative ability of two different external anchors: improvement appears better than importance. Authors and affiliation: Henrik H. Lauridsen, DC, MSc, PhD*, Claus Manniche, MD, DMSc‡, Werner Vach, PhD §, Niels Grunnet-Nilsson DC, MD, PhD*, Jan Hartvigsen, DC, PhD*† * Clinical...... better discriminative abilities compared to the importance criterion. Consequently, we recommend using improvement and not importance as an anchor to determine the MIC....

  10. Discriminative ability of two different external anchors: improvement appears better than importance

    DEFF Research Database (Denmark)

    Lauridsen, Henrik Hein

    Title:    Discriminative ability of two different external anchors: improvement appears better than importance. Authors and affiliation: Henrik H. Lauridsen, DC, MSc, PhD*, Claus Manniche, MD, DMSc‡, Werner Vach, PhD §, Niels Grunnet-Nilsson DC, MD, PhD*, Jan Hartvigsen, DC, PhD*†   * Clinical...... better discriminative abilities compared to the importance criterion. Consequently, we recommend using improvement and not importance as an anchor to determine the MIC....

  11. Fast Collision Attack on MD5

    NARCIS (Netherlands)

    Stevens, M.M.J.

    2006-01-01

    In this paper, we present an improved attack algorithm to find two-block collisions of the hash function MD5. The attack uses the same differential path of MD5 and the set of sufficient conditions that was presented by Wang et al. We present a new technique which allows us to deterministically fulfi

  12. Harvesting graphics power for MD simulations

    NARCIS (Netherlands)

    van Meel, J.A.; Arnold, A.; Frenkel, D.; Portegies Zwart, S.F.; Belleman, R.G.

    2008-01-01

    We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a congruentia

  13. 76 FR 52225 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Science.gov (United States)

    2011-08-22

    ... Model DC-9-81 (MD- 81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87), and MD-88 Airplanes AGENCY... Ground Floor, Room W12-140, 1200 New Jersey Avenue, SE., Washington, DC 20590. FOR FURTHER INFORMATION... ADs (b) None. Applicability (c) This AD applies to The Boeing Company Model DC-9-81 (MD-81),...

  14. First thoughts on MD priorities for 2012

    CERN Document Server

    Zimmermann, F; Assmann, R

    2012-01-01

    In 2012, 22 days of beam time will be allocated for LHC MDs. In this paper, after recalling the 2011 LHC MD experience, the MD rrequests for 2012 are reviewed. Three primary MD themes for 2012 can be identified: 1)pushing performance in 2012, 2)preparing for 2014/15, and 3)towards maximum luminosity. Example topics include emittance growth in collision or enhanced satellites for theme 1), 25 ns operation for 2), and ATS optics for 3). Structures lists of MD requests and topics for each theme as well as some initial thoughts on the MD priorities are presented. For certain topics, "start-of-fill MDs" are proposed in order to most efficiently use of the available beam time.

  15. 48 CFR 1316.601-70 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Time-and-Materials, Labor-Hour, and Letter Contracts 1316.601-70 Contract clauses. Insert clause 1352.216-77, Ceiling Price, in all time-and-materials contracts....

  16. 48 CFR 229.402-70 - Additional clauses.

    Science.gov (United States)

    2010-10-01

    ... Germany, use the clause with its Alternate I. (b) Use the clause at 252.229-7002, Customs Exemptions (Germany), in solicitations and contracts requiring the import of U.S. manufactured products into...

  17. CLAUSE AS THE TRANSLATION UNIT IN CHINESE TO ENGLISH TRANSLATION

    Institute of Scientific and Technical Information of China (English)

    向阳

    2001-01-01

    On the basis of Halliday' s theory, this paper makes it clear that clause as the translation unit is operational in Chinese to English translation and expounds the application of clause as the translation unit with some examples.

  18. Semantic Bias in the Acquisition of Relative Clauses in Japanese

    Science.gov (United States)

    Ozeki, Hiromi; Shirai, Yasuhiro

    2010-01-01

    This study analyzes the acquisition of relative clauses in Japanese to determine the semantic and functional characteristics of children's relative clauses in spontaneous speech. Longitudinal data from five Japanese children are analyzed and compared with English data (Diessel & Tomasello, 2000). The results show that the relative clauses produced…

  19. 48 CFR 1615.470-1 - Investment income clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Investment income clause. 1615.470-1 Section 1615.470-1 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT... CONTRACTING BY NEGOTIATION Contract Pricing 1615.470-1 Investment income clause. The clause set forth in...

  20. Cryptographic protocol verification using tractable classes of horn clauses

    DEFF Research Database (Denmark)

    Seidl, Helmut; Neeraj Verma, Kumar

    2007-01-01

    We consider secrecy problems for cryptographic protocols modeled using Horn clauses and present general classes of Horn clauses which can be efficiently decided. Besides simplifying the methods for the class of flat and onevariable clauses introduced for modeling of protocols with single blind...

  1. 78 FR 21343 - New Ski Area Water Rights Clause

    Science.gov (United States)

    2013-04-10

    ... Forest Service New Ski Area Water Rights Clause AGENCY: Forest Service, USDA. ACTION: Notice of meeting... rights clause for ski area permits issued by the Forest Service. There will be several stations at the... Service will consider in developing a new ski area water rights clause. There will be another...

  2. 48 CFR 52.241 - Utility Services Provisions and Clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Utility Services Provisions and Clauses. 52.241 Section 52.241 Federal Acquisition Regulations System FEDERAL ACQUISITION... Clauses 52.241 Utility Services Provisions and Clauses....

  3. 48 CFR 1852.227-84 - Patent rights clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Patent rights clauses. 1852... 1852.227-84 Patent rights clauses. The contracting officer shall insert the following provision as prescribed in 1827.303-70(e): Patent Rights Clauses (DEC 1989) This solicitation contains the patent...

  4. Spin interaction in octahedral zinc complexes of mono- and diradical Schiff and mannich bases.

    Science.gov (United States)

    Orio, M; Philouze, C; Jarjayes, O; Neese, F; Thomas, F

    2010-01-18

    The four Schiff bases 2-tert-butyl-4-methoxy-6-[(pyridin-2-ylmethylimino)methyl]phenol, 2,4-di-tert-butyl-6-[(pyridin-2-ylmethylimino)methyl]phenol, 2-tert-butyl-4-methoxy-6-(quinolin-8-yliminomethyl)phenol, and 2,4-di-tert-butyl-6-(quinolin-8-yliminomethyl)phenol) as well as one Mannich base, N,N',N,N'-bis[(2-hydroxy-3,5-di-tert-butylbenzyl)(2-pyridylmethyl)]ethylenediamine, and their zinc bis-phenolate complexes 1-5, respectively, have been prepared. The complexes 4 and 5 have been characterized by X-ray diffraction crystallography, showing a zinc ion within an octahedral environment, with a cis orientation of the phenolate moieties. 1-5 exhibit in their cyclic voltammetry curves two anodic reversible waves attributable to the successive oxidation of the phenolates into phenoxyl radicals. Bulk electrolysis at ca. +0.1 V affords the zinc-coordinated monophenoxyl radical species (1(*))(+)-(5(*))(+) characterized by UV-vis absorption bands at 400-440 nm. The more stable radicals are (3(*))(+) and (4(*))(+) (half-life higher than 90 min at 298 K), likely due to the increased charge delocalization within the quinoline moieties. These species exhibit a significant additional near-IR band (epsilon > 1650 M(-1) cm(-1)) attributed to a CT transition. In the two-electron-oxidized species (1(**))(2+)-(5(**))(2+) the radical spins present a weak magnetic coupling. EPR reveals an antiferromagnetic exchange interaction for (1(**))(2+)-(4(**))(2+), whereas an unusual ferromagnetic exchange coupling is operative in (5(**))(2+). The weak magnitude of experimental |J| values (within the 1-5 cm(-1) range) as well as their sign could be well reproduced by DFT calculations at the B3LYP level. The small energy gap between the ground and the first excited spin states allows us to investigate the zero-field splitting (ZFS) of the triplet by EPR spectroscopy. This parameter is found to be axial for all systems, with |D| values of 0.0163 cm(-1) for (1(**))(2+), 0.0182 cm(-1) for (2

  5. PODI AND ODI IN CLAUSE CONSTRUCTION OF KEMAK

    Directory of Open Access Journals (Sweden)

    I Wayan Budiarta

    2013-03-01

    Full Text Available This article reveals podi and odi in clause construction of Kemak. Specifically, this article is aimed at finding out in what construction  podi and odi appear. Moreover, this article is also aimed at finding out the function of podi and odi in the clause construction of Kemak. Before exploring podi and odi in clause construction, the first discussion will examine the morphology of the verb of Kemak to find out how the verbs are formed in Kemak as they have the main role to fill the predicate. The discussion continues to examine the clause with nonverbal (verbless and verbal predicate. Clause with nonvebral (verbless predicate will begin the discussion on clause construction in Kemak. Then, the discussion goes to clause with verbal predicate. The clause with verbal predicate includes intransitive and transtive. The disscussion of transitive clause covers monotransitive and  ditransitive clause. The  study on transitive clause is related to the presence of podi and odi in the construction.The result shows that all verbs are basic verbs. Verbs in Kemak are morphologically unmarked (no affixes and there is no agreement between the verb and its arguments. The clause with nonverbal predicate in Kemak is filled by  noun, adjective, numeral, and prepositional phrase. Clause with nonverbal predicate requires one argument  functioning as grammatical subject. As cluase with nonverbal predicate, intransitive clause in Kemak also requires one argument  functioning as grammatical subject. Meanwhile, monotransitive clause requires two arguments, preverbal and postverbal argument. Ditranstive clause requires three arguments, one preverbal and two postverbal argument. Moreover, it was found that  podi appears in ditransitive clause (applicative/benefactive construction. Podi has the function to increase the verb valence from monotransitive into ditransitive. Meanwhile, odi appears in monotransitive clause  The presence of odi in monotrasitive is as the

  6. 48 CFR 923.7003 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 923.7003 Section 923.7003 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS..., the contract or subcontract must include language to specify the extent of applicability of...

  7. 48 CFR 46.710 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... and Equipment under Performance Specifications or Design Criteria, in solicitations and contracts when performance specifications or design are of major importance; a fixed-price supply, service, or research and... clause at 52.246-19, Warranty of Systems and Equipment under Performance Specifications or...

  8. Head Position and Internally Headed Relative Clauses.

    Science.gov (United States)

    Basilico, David

    1996-01-01

    Examines "Head Movement" in internally headed relative clauses (IHRCs). The article shows that in some cases, head movement to an external position need not take place and demonstrates that this movement of the head to a sentence-internal position results from the quantificational nature of IHRCs and Diesing's mapping hypothesis (1990, 1992). (56…

  9. Retrenchment Clauses in Faculty Union Contracts.

    Science.gov (United States)

    Rhoades, Gary

    1993-01-01

    Examination of retrenchment clauses in the faculty union contracts at 42 colleges and universities focused on implications for tenure rights and the roles prescribed for faculty and administrators. Concepts of financial exigency and shared governance are highlighted. Contracts were found to provide faculty with a limited and reactive role during…

  10. 48 CFR 13.302-5 - Clauses.

    Science.gov (United States)

    2010-10-01

    ... requirement unless the existing requirement is deleted. Also, do not delete a paragraph without providing for... cannot be set aside for small business concerns and trade agreements apply (see Subpart 25.4), substitute the clause at FAR 52.225-3, Buy American Act—Free Trade Agreements—Israeli Trade Act, used...

  11. Relative clauses in French children's narrative texts.

    Science.gov (United States)

    Jisa, H; Kern, S

    1998-10-01

    This study investigates the use of relative clauses in French children's narrative monologues. Narrative texts were collected from French-speaking monolinguals in four age groups (five, seven, ten years and adults). Twenty subjects from each group were asked to tell a story based on a picture book consisting of twenty-four images without text (Frog, Where are you?). Relative constructions were coded following the categories defined by Dasinger & Toupin (1994) into two main functional classes: general discourse and narrative functions. The results show that the use of relative clauses in general discourse functions precedes their use in more specific narrative functions. An analysis of textual connectivity (Berman & Slobin, 1994) in one episode reveals that children and adults differ in their choice of preferred structures. The results also show that children use fewer transitive predicates in relative clauses than do adults. Transitive verbs are essential for advancing the narrative plot (Hopper & Thompson, 1980). While subject relative clauses are acquired early and used frequently, the development of their multifunctional use in diverse narrative functions extends well beyond childhood.

  12. 48 CFR 503.1004 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract clauses. 503.1004 Section 503.1004 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Contractor Code of Business Ethics and Conduct...

  13. 48 CFR 1403.1004 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 1403.1004 Section 1403.1004 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Contractor Code of Business Ethics and Conduct...

  14. Obituary of Philip H. Cooper, MD.

    Science.gov (United States)

    Patterson, James W; Wick, Mark R; Mills, Stacey E

    2015-08-01

    Dermatopathology lost a giant in the field with the death of Philip H. Cooper, MD, on Friday, January 30, 2015. The following obituary represents a celebration of his life and his contributions to our field.

  15. An Efficient One-pot Synthesis of β-Amino/β-Acetamido Car-bonyl Compounds via ZrCl4-catalyzed Mannich-type Reaction

    Institute of Scientific and Technical Information of China (English)

    SANJEEVA REDDY,Cherkupally; PURNACHANDRA REDDY,Gurrala

    2008-01-01

    Zirconium(IV) chloride catalyzed efficient one-pot synthesis of β-amino/β-acetamido carbonyl compounds at room temperature is described. In the presence of ZrCl4, the three-component Mannich-type reaction via a variety of in situ generated aldimines, with various ketones, aromatic aldehydes and aromatic amines in ethanol, led to the formation of β-amino carbonyl compounds and the four-component Mannich-type reaction of aromatic aldehydes with various ketones, acetonitrile and acetyl chloride resulted in the corresponding β-acetamido carbonyl com-pounds in high to excellent yields. This methodology has also been applied towards the synthesis of dimeric β-amino/β-acetamido carbonyl compounds.

  16. MD5算法的分析和改进%Analysis and Improvement of .MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    么丽颖

    2011-01-01

    首先研究了MD5算法,并总结了MD5算法的特点及性能,在研究MD5算法的基础之上,提出了MD5改进加密算法.最后,对MD5算法与MD5改进算法对应于相关数据、性能进行了比较.%At first , MD5 algorithm is researched, and the characteristic and capability of the MD5 are summaried in the paper. The improved MD5 algorithm is put forward based on the research of the MDS. At last, the contrast between MD5 algorithm and the improved MD5 algorithm in related datum and capability are put forward.

  17. New Message Differences for Collision Attacks on MD4 and MD5

    Science.gov (United States)

    Sasaki, Yu; Wang, Lei; Kunihiro, Noboru; Ohta, Kazuo

    In 2005, collision resistance of several hash functions was broken by Wang et al. The strategy of determining message differences is the most important part of collision attacks against hash functions. So far, many researchers have tried to analyze Wang et al.'s method and proposed improved collision attacks. Although several researches proposed improved attacks, all improved results so far were based on the same message differences proposed by Wang et al. In this paper, we propose new message differences for collision attacks on MD4 and MD5. Our message differences of MD4 can generate a collision with complexity of less than two MD4 computations, which is faster than the original Wang et al.'s attack, and moreover, than the all previous attacks. This is the first result that improves the complexity of collision attack by using different message differences from Wang et al.'s. Regarding MD5, so far, no other message difference from Wang et al.'s is known. Therefore, study for constructing method of other message differences on MD5 should be interesting. Our message differences of MD5 generates a collision with complexity of 242 MD5 computations, which is slower than the latest best attack. However, since our attack needs only 1 bit difference, it has some advantages in terms of message freedom of collision messages.

  18. Hierarchical State Machines as Modular Horn Clauses

    Directory of Open Access Journals (Sweden)

    Pierre-Loïc Garoche

    2016-07-01

    Full Text Available In model based development, embedded systems are modeled using a mix of dataflow formalism, that capture the flow of computation, and hierarchical state machines, that capture the modal behavior of the system. For safety analysis, existing approaches rely on a compilation scheme that transform the original model (dataflow and state machines into a pure dataflow formalism. Such compilation often result in loss of important structural information that capture the modal behaviour of the system. In previous work we have developed a compilation technique from a dataflow formalism into modular Horn clauses. In this paper, we present a novel technique that faithfully compile hierarchical state machines into modular Horn clauses. Our compilation technique preserves the structural and modal behavior of the system, making the safety analysis of such models more tractable.

  19. Novel aminonaphthoquinone mannich bases derived from lawsone and their copper(II) complexes: synthesis, characterization and antibacterial activity

    Energy Technology Data Exchange (ETDEWEB)

    Neves, Amanda P.; Barbosa, Claudia C.; Greco, Sandro J.; Vargas, Maria D. [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Inst. de Quimica; Visentin, Lorenzo C. [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Inst. de Quimica; Pinheiro, Carlos B. [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Dept. de Fisica; Mangrich, Antonio S. [Universidade Federal do Parana (UFPR), Curitiba, PR (Brazil). Centro Politecnico. Dept. de Quimica; Barbosa, Jussara P.; Costa, Gisela L. da [Instituto Oswaldo Cruz, Rio de Janeiro, RJ (Brazil)

    2009-07-01

    A series of novel Mannich bases (HL1-HL13) derived from 2-hydroxy-1,4-naphthoquinone (lawsone), substituted benzaldehydes [C{sub 6}H{sub 2}R{sup 1}R{sup 2}R{sup 3}C(O)H] and various primary amines (NH{sub 2}R{sup 4}, R{sup 4} = n-butyl, benzyl, allyl, 2-furfuryl), and their Cu{sup 2+} complexes, [Cu(L1){sub 2}]-[Cu(L13){sub 2}], have been synthesized and fully characterized by analytical and spectroscopic methods. The structures of complexes 1 (R{sup 1} R{sup 2} = R{sup 3} = H; R{sup 4} = Bu), 2 (R{sup 1} = R{sup 3} = H; R{sup 2} = NO{sub 2}; R{sup 4}= Bu) and 7 (R{sup 1} OH; R{sup 2} = R{sup 3} = H; R{sup 4}= Bu) were determined by single crystal X-ray diffraction studies. All complexes crystallize in centrosymmetric space groups, with a copper atom in the inversion centre. Two L. coordinate through the naphthalen-2-olate oxygen and secondary amine-N atoms, forming six membered chelate rings around the copper atom in a trans-N{sub 2}O{sub 2} environment; spectroscopic data confirm that the other complexes exhibit similar molecular arrangement. The antimicrobial activity of all compounds has been tested on seven different strains of bacteria: Bacillus cereus, Bacillus subtilis, Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae, Pseudomonas aeruginosa and Staphylococcus aureus. In general, Mannich bases were more active than complexes, HL11 (R{sup 1} = OH; R{sup 2} =H; R{sup 3} = Me; R{sup 4}= Bn) and HL13 (R{sup 1} = OH; R{sup 2} = H; R{sup 3} = Br; R{sup 4}= Bn) being the most potent inhibitors. The MIC for the most active compound HL11 against S. Coli was 20 {mu}mol L{sup -1} (8 {mu}g mL{sup -1}), better than Chloramphenicol (90 {mu}mol L{sup -1}) and well below most values reported for other naphthoquinones. (author)

  20. What undertakings are protected under Umbrella Clauses of BITs.

    OpenAIRE

    Khasanov, Jamshid

    2015-01-01

    The thesis is discusses what is the scope of Umbrella Clauses. State undertakings must satisfy the condition of being investment. That is the first requirement of applicability of investment regime to state undertakings. Despite state undertakings was seen as wide concept (by some tribunals) the language of the clause and prevailing view support undertakings must be limited to contractual undertakings (in practice some viewed that Umbrella Clause can be extended to municipal law obligations) ...

  1. 75 FR 1788 - General Services Administration Regulation; Submission for OMB Review; Packing List Clause

    Science.gov (United States)

    2010-01-13

    ... ADMINISTRATION General Services Administration Regulation; Submission for OMB Review; Packing List Clause AGENCY... approved information collection requirement regarding the packing list clause. A request for public..., Packing List Clause, in all correspondence. FOR FURTHER INFORMATION CONTACT: Michael O....

  2. 77 FR 66466 - General Services Administration Regulation; Information Collection; Packing List Clause

    Science.gov (United States)

    2012-11-05

    ... ADMINISTRATION General Services Administration Regulation; Information Collection; Packing List Clause AGENCY... packing list clause. Public comments are particularly invited on: Whether this collection of information..., Packing List Clause, by any of the following methods: Regulations.gov :...

  3. A sensitive spectrofluorimetric method for the quantification of melamine residue in milk powder using the Mannich reaction in aqueous solutions.

    Science.gov (United States)

    Rima, Jamil; Assaker, Karine; El Omar, Fawaz; karim, Chawki bou

    2013-11-15

    The objective of this study was to develop a spectrofluorimetric method for the quantitative determination of melamine. The method was based on the complexation of melamine with a mixture of formaldehyde and chemicals including a ketone group, as described by the Mannich reaction. The complex was determined by spectrofluorimetric measurement as it is characterized by specific spectroscopic properties that are related to the chromophore of the ketone compounds. 1,3-Diphenylpropane-1,3-dione (DPPD) was tested as a ketone compound. The fluorescence spectrum of the complex presented a maximum of absorption at 325 nm.A quenching of the fluorescence occurred when melamine was added into the solution. The kinetic of fluorescence quenching was followed to determine quantitatively the melamine concentration. An internal standard was added to quantify melamine. The method was tested to determine the level of melamine in contaminated milk powder. The recovery value was 97% and the limit of detection was 0.007 μg mL(-1.)

  4. 76 FR 77579 - Maryland Disaster #MD-00017

    Science.gov (United States)

    2011-12-13

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Maryland Disaster MD-00017 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... INFORMATION CONTACT: A. Escobar, Office of Disaster Assistance, U.S. Small Business Administration, 409...

  5. 78 FR 2707 - Maryland Disaster # MD-00026

    Science.gov (United States)

    2013-01-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Maryland Disaster MD-00026 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... INFORMATION CONTACT: A. Escobar, Office of Disaster Assistance, U.S. Small Business Administration, 409...

  6. Hazardous Waste Minimization Assessment: Fort Meade, MD

    Science.gov (United States)

    1991-01-01

    Audit." in Wuem Mbdmi1zmim Mama (Govarmmu Inlmdu he.. Roeehdmf, MD. 19), pp 61-73 M.L R=. "Haudow Wons Mhbdms Aisu Usi4 a Two-Timed Appm." rw£nwwd...severe health problems (e.g.. gastric disorders, skin lesions. swollen limbs, cancers. tumors , eye problems. liver disorders, menstrual irregularities

  7. 48 CFR 225.7007-3 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clause. 225.7007-3 Section 225.7007-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... granted, use the clause at 252.225-7019, Restriction on Acquisition of Anchor and Mooring Chain,...

  8. The Production of Complement Clauses in Children with Language Impairment

    Science.gov (United States)

    Steel, Gillian; Rose, Miranda; Eadie, Patricia

    2016-01-01

    Purpose: The purpose of this research was to provide a comprehensive description of complement-clause production in children with language impairment. Complement clauses were examined with respect to types of complement structure produced, verb use, and both semantic and syntactic accuracy. Method: A group of 17 children with language impairment…

  9. 32 CFR 643.55 - Mandatory revocation clause in lease.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Mandatory revocation clause in lease. 643.55... PROPERTY REAL ESTATE Leases § 643.55 Mandatory revocation clause in lease. Each lease will contain a provision permitting the SA to revoke the lease at any time, unless it is determined that the omission...

  10. The Acquisition of Relative Clauses by Tamil Children.

    Science.gov (United States)

    Lakshmanan, Usha

    2000-01-01

    Reports the findings of a cross-sectional study that investigated the acquisition of relative clauses by 27 Tamil-speaking children who ranged in age from 2 years and 11 months to 6 years and 6 months. A picture-cued production task was used to elicit relative clauses from the child subjects. (Author/VWL)

  11. 48 CFR 3427.471 - Paperwork Reduction Act clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Paperwork Reduction Act... Copyrights 3427.471 Paperwork Reduction Act clause. The contracting officer shall insert the clause in 3452.227-71, Paperwork Reduction Act, in all solicitations and contracts....

  12. 48 CFR 511.204 - Solicitation provisions and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... officer shall insert the clause at 552.211-72, Reference to Specifications in Drawings, in solicitations... Schedule containing information technology Special Item Numbers; or (ii) Federal Supply Schedules for... contracting officer shall include the clause 552.211-92, Radio Frequency Identification (RFID) using...

  13. 41 CFR 60-300.5 - Equal opportunity clause.

    Science.gov (United States)

    2010-07-01

    ... be filled from within the contractor's organization, and positions lasting three days or less. This term includes full-time employment, temporary employment of more than three days' duration, and part... opportunity clause in the contract. It is not necessary that the equal opportunity clause be quoted...

  14. 48 CFR 811.104-71 - Purchase description clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Purchase description... Documents 811.104-71 Purchase description clauses. (a) When a solicitation uses “brand name or equal” purchase descriptions, the contracting officer must include in the solicitation the clause at...

  15. 37 CFR 401.13 - Administration of patent rights clauses.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Administration of patent rights clauses. 401.13 Section 401.13 Patents, Trademarks, and Copyrights ASSISTANT SECRETARY FOR... patent rights clauses. (a) In the event a subject invention is made under funding agreements of more...

  16. 48 CFR 3427.472 - Advertising of awards clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Advertising of awards... Copyrights 3427.472 Advertising of awards clause. The contracting officer shall insert the clause in 3452.227-72, Advertising of Awards, in all solicitations and contracts other than purchase orders....

  17. On the phrasing properties of Hindi relative clauses

    NARCIS (Netherlands)

    Gryllia, S.; Féry, C.; Kügler, F.; Pandey, P.; The, Scottish Consortium for ICPhS 2015

    2015-01-01

    This paper presents results from a production experiment in Hindi, showing that differences in attachment site of object relative clauses result in prosodic differences when the antecedent of the relative clause (RC) is part of a complex NP with the structure N1 of N2. In particular, based on durati

  18. An efficient synthesis of β-amino ketone compounds through one-pot three-component Mannich-type reactions using bismuth nitrate as catalyst

    Directory of Open Access Journals (Sweden)

    S. Sheik Mansoor

    2015-07-01

    Full Text Available Three components one-pot Mannich reaction of aromatic ketone, aromatic aldehyde and aromatic amines has been efficiently catalyzed by recyclable bismuth nitrate (Bi(NO33, BN at ambient temperature to give various β-amino carbonyl compounds in high yields. This method has advantages of mild condition, no environmental pollution, and simple work-up procedures. Most importantly, β-amino carbonyl compounds with ortho-substituted aromatic amines are obtained in acceptable to moderate yields by this methodology.

  19. Direct NOE simulation from long MD trajectories

    Science.gov (United States)

    Chalmers, G.; Glushka, J. N.; Foley, B. L.; Woods, R. J.; Prestegard, J. H.

    2016-04-01

    A software package, MD2NOE, is presented which calculates Nuclear Overhauser Effect (NOE) build-up curves directly from molecular dynamics (MD) trajectories. It differs from traditional approaches in that it calculates correlation functions directly from the trajectory instead of extracting inverse sixth power distance terms as an intermediate step in calculating NOEs. This is particularly important for molecules that sample conformational states on a timescale similar to molecular reorientation. The package is tested on sucrose and results are shown to differ in small but significant ways from those calculated using an inverse sixth power assumption. Results are also compared to experiment and found to be in reasonable agreement despite an expected underestimation of water viscosity by the water model selected.

  20. MD5的Keygenme分析

    Institute of Scientific and Technical Information of China (English)

    Firebig

    2006-01-01

    闲来无事,抓出个不知何时下的Keygenme练练手,分析后可知.这个Keygenme有2张数据表,由注册名经MD5运算后进行查表,得出2个DWORD数据.然后再由注册码经过一个可逆循环得出2个DWORD数据.最后对比是否正确。(MD5的具体介绍黑防6期有说明)

  1. Batch By Batch Longitudinal Emittance Blowup MD

    CERN Document Server

    Mastoridis, T; Butterworth, A; Jaussi, M; Molendijk, J

    2012-01-01

    The transverse bunch emittance increases significantly at 450 GeV from the time of injection till the ramp due to IBS. By selectively blowing up the longitudinal emittance of the incoming batch at each injection, it should be possible to reduce the transverse emittance growth rates due to IBS. An MD was conducted on April 22nd 2012 to test the feasibility and performance of the batch-by-batch longitudinal emittance blowup. There were three main goals during the MD. First, to test the developed hardware, firmware, and software for the batch-by-batch blowup. Then, to measure the transverse emittance growth rates of blown-up and "witness" batches to quantify any improvement, and finally to test the ALLInjectSequencer class, which deals with the complicated gymnastics of introducing or masking the new batch to various RF loops.

  2. MD on UFOs at MKIs and MKQs

    CERN Document Server

    Baer, T; Bartmann, W; Bracco, C; Carlier, E; Dehning, B; Garrel, N; Goddard, B; Jackson, S; Jimenez, M; Kain, V; Mertens, V; Misiowiec, M; Nordt, A; Papotti, G; Uythoven, J; Wenninger, J; Zerlauth, M; Zamantzas, C; Zimmermann, F

    2012-01-01

    UFOs ("Unidentified Falling Objects") are expected to be one of the major known performance limitation of the LHC. In this MD, the production mechanism and the dynamics of UFOs at the injection kicker magnets (MKIs) and the tune kicker magnets (MKQs) were studied. This was done by pulsing the MKIs and MKQs on a gap in the partly filled machine. During the MD, in total 58 UFO-type beam loss patterns were observed directly after pulsing the MKIs. None were observed after pulsing the MKQs, which provides important input for possible mitigation strategies. The temporal and spatial distribution of the UFO events could be determined by using a dedicated BLM Study Buffer, the implications for the UFO dynamics are discussed.

  3. Classical MD calculations with parallel computers

    Energy Technology Data Exchange (ETDEWEB)

    Matsumoto, Mitsuhiro [Nagoya Univ. (Japan)

    1998-03-01

    We have developed parallel computation codes for a classical molecular dynamics (MD) method. In order to use them on work station clusters as well as parallel super computers, we use MPI (message passing interface) library for distributed-memory type computers. Two algorithms are compared: (1) particle parallelism technique: easy to install, effective for rather small number of processors. (2) region parallelism technique: take some time to install, effective even for many nodes. (J.P.N.)

  4. The in vitro and in vivo antimalarial activity of some Mannich bases derived from 4-(7'-trifluoromethyl-1',5'-naphthyridin-4'-ylamino)phenol, 2-(7'-trifluoromethyl-quinolin-4'-ylamino)phenol, and 4'-chloro-5-(7''-trifluoromethylquinolin-4''-ylamino)biphenyl -2-ols.

    Science.gov (United States)

    Barlin, G B; Jiravinyu, C; Butcher, G A; Kotecka, B; Rieckmann, K

    1992-08-01

    A series of di-Mannich base derivatives (4 and 5) from 4-(7'-trifluoromethyl-1',5'-naphthyridin-4'-ylamino)phenol and 2-(7'-trifluoromethylquinolin-4'-ylamino)phenol, respectively, and mono-Mannich base derivatives (6) from 4'-chloro-5-(7''-trifluoromethylquinolin-4''- ylamino)biphenyl-2-ol were assayed for activity against the chloroquine-sensitive (FCQ-27) isolate of cultured Plasmodium falciparum using the inhibition of uptake of radiolabelled hypoxanthine. All seven di-Mannich base derivatives (5) revealed a higher activity than chloroquine, whereas the di-Mannich base derivatives (4) were slightly less active (with some derivatives more active and some less active than chloroquine). The mono-Mannich base derivatives (6) were less active than chloroquine. Comparative tests of selected compounds of (4 and 5) using a morphological assay revealed no significant differences in activity between the chloroquine-sensitive (FCQ-27) and chloroquine-resistant (K-1) isolates. Selected di-Mannich bases (4 and 5) and the mono-Mannich bases 5-7''-bromo (and 7-trifluoromethyl)-1'',5''-naphthyridin-4''-ylamino)-3-(t- butylaminomethyl)-4'-chlorobiphenyl-2-ols (7, X = Br, CF3) markedly suppressed parasitaemia in Plasmodium vinckei vinckei infected mice when administered (i.p.) in a single dose of 200 mg kg-1.

  5. CeCl_3·7H_2O as an efficient catalyst for one-pot synthesis of β-amino ketones by three-component Mannich reaction

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Cerium trichloride heptahydrate(CeCl_3·7H_2O) was found to be an efficient and recyclable catalyst for the three-component direct Mannich reaction of anilines and benzaldehydes with acetophenone.This protocol has advantages of high yield,no environmental pollution,mild condition,and simple work-up procedure.

  6. First principles and DFT supported investigations on vibrational spectra and electronic structure of 2-((phenylamino)methyl)isoindoline-1,3-dione - An antioxidant active Mannich base

    Science.gov (United States)

    Boobalan, Maria susai; Amaladasan, M.; Ramalingam, S.; Tamilvendan, D.; Venkatesa Prabhu, G.; Bououdina, M.

    2015-02-01

    The 2-((phenylamino)methyl)isoindoline-1,3-dione (PID) is a synthesized Mannich base which has significant antioxidant activity and biological importance. Quantum mechanical calculations on energy, geometry and vibrational wavenumber of PID were computed using ab initio HF and density functional theory (DFT/B3LYP) methods with 6-31+G/6-311++G(d,p) basis sets. Optimized geometrical parameters obtained by HF and DFT calculations were indicatively agreement with experimental crystal geometry. The experimental FT-Raman and FT-IR spectra of PID has been recorded and analyzed by comparing with simulated spectra. The 1H and 13C NMR spectra of title molecule records the chemical shift resulted from shielding and deshielding effects. Natural bond orbital (NBO) analysis has been carried out to calculate various intramolecular interactions that are accountable for the stabilization of this Mannich base. The predicted HOMO-LUMO gap offers interesting information on intramolecular charge transfer and reactivity of the molecular system. Molecular electrostatic potential (MEP) imprint visualize the reactive sites in PID, which is also supported by Mulliken, ESP, Hirshfeld and NBO charges. Thermodynamic properties of PID at various temperatures have been calculated at B3LYP/6-311++G(d,p) in gas phase and the correlations between standard entropies (S), internal energy (E or U) and standard heat capacity (C) with different temperatures.

  7. Integrative Medicine Program- MD Anderson Cancer Center

    Directory of Open Access Journals (Sweden)

    Richard T Lee

    2012-06-01

    Full Text Available The Integrative Medicine Program at MD Anderson Cancer Center was first established in 1998.  Our mission is to empower patients with cancer and their families to become active partners in their own physical, psycho-spiritual, and social health through personalized education and evidenced-based clinical care to optimize health, quality of life, and clinical outcomes across the cancer continuum.  The program consists of three main components: clinical care, research, and education.  The Integrative Medicine Center provides clinical services to patients through individual and group programs.  The clinical philosophy of the center is to work collaboratively with the oncology teams to build comprehensive and integrative care plans that are personalized, evidence-based, and safe with the goal of improving clinical outcomes.  The individual services comprise of integrative oncology consultation, acupuncture, meditation, music therapy, nutrition, and oncology massage.  The center also provides a variety of group programs including meditation, yoga, tai chi, cooking classes and others.  Over the past 13 years, over 70,000 patients and families have participated in services and programs offered by the center.  The research portfolio focuses on three main areas: mind-body interventions, acupuncture, and meditation.  This lecture will focus on providing an overview of the Integrative Medicine Program at MD Anderson with a focus on the clinical services provided.  Participants will learn about the integrative clinical model and how this is applied to the care of cancer patients at MD Anderson Cancer Center.  Current and future research topics will be discussed as well as patient cases.

  8. Claus recycle with double combustion process

    Energy Technology Data Exchange (ETDEWEB)

    El-Bishtawi, Ribhi; Haimour, No' man [University of Jordan, Amman 11942 (Jordan)

    2004-12-15

    A new modification is developed on conventional Claus process to increase the overall sulfur recovery as well as to decrease the costs. The modification combines both oxygen enrichment and recycling. The process is simulated and studied for various N{sub 2}/O{sub 2} ratios with and without using SURE double combustion technique. The predictions show that using pure oxygen in combustion, condensing water vapor in a condenser following the first sulfur condenser and recycling the effluent gas to combine it with fresh acid gas feed leads to large savings in the production cost and to a clean environment. However, it leads to a high adiabatic flame temperature which exceeds the maximum allowable temperature of the furnace material of construction as well as its refractory. To avoid these effects, it is necessary to use SURE double combustion technique. The oxygen flow rate to the first combustion stage should not exceed 78% O{sub 2}.

  9. Computer Security: a plea to Santa Claus

    CERN Multimedia

    Stefan Lueders, Computer Security Team

    2015-01-01

    Running pirated software or illegal licences, using cracking tools to bypass software activation measures, sharing music and films – these are problems that academic environments unfortunately have to deal with. All violate the copyright of the software/music/film owners, and copyright owners are not Santa Claus...    CERN, like other research organisations and universities, regularly receives allegations from external companies complaining about laptops or PCs running illegal software or sharing their films, videos or music with peers – and thus violating copyright.  Usually, we then contact the owners of the corresponding devices in order to understand whether these allegations are true. Very often such allegations boil down to a laptop whose owner replies “I confirm that a torrent client was left up and running on my device by mistake” or “This is a file that is stored on my personal hard disk.” As if those allegatio...

  10. ‘De Regenkoning’ van Hugo Claus

    Directory of Open Access Journals (Sweden)

    S. W. van Zuydam

    1986-05-01

    Full Text Available The investigation in this article comprises the analysis of a poem by the Flemish author Hugo Claus, namely "De regenkoning". It is one of the poems in a sequence entitled "De ingewijde" (The initiated which forms part of his volume of poetry "De Oostakkerse Gedichten” (1955. These poems are extremely esoteric and an attempt is made here to “decode” the "hidden mysteries” in this particular poem. Claus’ method of using a kind of secret language corresponds to a basic feature of (universal initiation ceremonies, namely that everything that takes place is shrouded in secrecy. It was found that the nucleus of traditional initiations, namely sexual and mental maturation, likewise form a fundamental characteristic in Claus’ poem. Yet his "neophyte” is not (reborn into a "new” (sacred world, but initiated into the broken (profane realities of modern society.

  11. Natural syntax : English interrogative main clauses

    Directory of Open Access Journals (Sweden)

    Janez Oresnik

    2007-12-01

    Full Text Available Natural Syntax is a developing deductive theory, a branch of Naturalness Theory. The naturalnessjudgements are couched in naturalness scales, whichfollow from the basic parameters (or «axioms» listed at the beginning of the paper. The predictions of the theory are calculated in deductions, whose chief components are apair of naturalness scales and the rules governing the alignment of corresponding naturalness values. Parallel and chiastic alignments are distinguished, in complementary distribution. Chiastic alignment is mandatory in deductions limited to unnatural environments. The paper deals with English interrogative main clauses. Within these, only the interrogatives containing wh-words exclusively insitu constitute an extremely unnatural environment and require chiastic alignment. Otherwiseparallel alignment is used. Earlier publications on Natural Syntax: Kavcic 2005a,b, Oresnik 1999, 2000a,b, 200la-f   2002, 2003a-c, 2002/03, 2004. This list cites only works written in English.

  12. Orlando C. Kirton, MD, FACS, FCCM, FCCP.

    Science.gov (United States)

    Pyrtek, Ludwig J

    2007-12-01

    The chair is named for Ludwig J. Pyrtek, MD, an esteemed surgeon at Hartford Hospital, who was devoted to the care of his patients and was an outstanding educator within his chosen field. A unique aspect of the chair is that its income is not used to support the salary of the director but is used to enhance the education activities of the department, such as the purchasing of state-of-the-art teaching devices, support of surgical resident research activities, educational travel for residents and honoraria for nationally/internationally known clinicians/scientists to speak at grand rounds.

  13. Dawbeney Turbervile, MD (1612-1696).

    Science.gov (United States)

    Simunovic, Matthew P

    2012-03-01

    The year 2012 marks the quatercentenary of the birth of Dawbeney Turbervile,MD(1612-1696), one-time Royalist soldier and later ophthalmologist to England’s Princess Anne, the diarist Samuel Pepys, the natural philosopher Robert Boyle, and the astronomer Walter Pope. Turbervile is remarkable for many reasons: He specialized at a time when generalization was prized; though he was a qualified physician, he also practiced the trade of surgery. Furthermore, he provided in his communications with the Royal Society early descriptions of achromatopsia, ocular foreign body removal with a magnet, and tic doloreaux. He is a forebear worth remembering

  14. ProtoMD: A prototyping toolkit for multiscale molecular dynamics

    Science.gov (United States)

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2016-05-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates 'GROMACS wrapper' to initiate MD simulations, and 'MDAnalysis' to analyze and manipulate trajectory files. It facilitates experimentation with a spectrum of coarse-grained variables, prototyping rare events (such as chemical reactions), or simulating nanocharacterization experiments such as terahertz spectroscopy, AFM, nanopore, and time-of-flight mass spectroscopy. ProtoMD is written in python and is freely available under the GNU General Public License from github.com/CTCNano/proto_md.

  15. A U-Shaped Relative Clause Attachment Preference in Japanese.

    Science.gov (United States)

    Miyamoto, Edson T.; Gibson, Edward; Pearlmutter, Neal J.; Aikawa, Takako; Miyagawa, Shigeru

    1999-01-01

    Presents results from a self-paced reading experiment in Japanese investigating attachment preferences for relative clauses to three ensuing potential nominal heads. Results are discussed in light of two types of parsing models. (Author/VWL)

  16. 48 CFR 339.7103 - Solicitation and contract clause.

    Science.gov (United States)

    2010-10-01

    ... clause. 339.7103 Section 339.7103 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES...-72, Security Requirements for Federal Information Technology Resources, in solicitations and contracts that involve contractor access to Federal information or Federal information systems....

  17. 48 CFR 1227.305 - Administration of patent rights clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administration of patent... TRANSPORTATION GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights Under Government Contracts 1227.305 Administration of patent rights clauses....

  18. 48 CFR 1327.305 - Administration of patent rights clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administration of patent... GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights Under Government Contracts 1327.305 Administration of patent rights clauses....

  19. 48 CFR 2427.305 - Administration of patent rights clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Administration of patent... AND URBAN DEVELOPMENT SOCIOECONOMIC PROGRAMS PATENTS, DATA, AND COPYRIGHTS Patent Rights Under Government Contracts 2427.305 Administration of patent rights clauses....

  20. 48 CFR 27.305 - Administration of patent rights clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Administration of patent... REGULATION GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights under Government Contracts 27.305 Administration of patent rights clauses....

  1. 曼尼希碱的结构与其缓蚀性能的关系%The relationship between the structures of Mannich bases and the anti-corrosion performances

    Institute of Scientific and Technical Information of China (English)

    战风涛; 丁鹏鹏; 吕志凤; 高统海; 周昕媛

    2016-01-01

    利用曼尼希反应制得了曼尼希碱1-苯基-3-二乙氨基-1-丙酮( DPO),再利用DPO和伯胺(苄胺、对甲基苯胺、苯胺)进行胺交换反应,制得了结构不同的曼尼希碱:1-苯基-3-苄氨基-1-丙酮( BPO )、1-苯基-3-对甲苯氨基-1-丙酮( TPO)和1-苯基-3-苯氨基-1-丙酮( PPO)。静态失重法和极化曲线法研究结果表明,其在15%盐酸中90℃时对N80钢的缓蚀性能大小顺序为:DPO<BPO<TPO<PPO。四种曼尼希碱缓蚀剂在N80钢表面上的吸附遵循Langmuir吸附模型,吸附能力大小顺序为:DPO<BPO<TPO<PPO,这说明当曼尼希碱分子中氨基与苯环形成富电子共轭体系时,其吸附能力较强,可表现出较强的缓蚀性能。%Mannich bases,3-diethylamino-1-phenylpropan-1-one (DPO),was prepared by Mannich reac-tion.Mannich bases , 3-benzylamino-1-phenylpropan-1-one ( BPO ) , 3-p-toluidino-1-phenylpropan-1-one (TPO) and 3-phenylamino-1-phenylpropan-1-one (PPO),were prepared by amine exchange reactions between DPO and primary amines ( benzylamine , p-toluidine and aniline ) .The anti-corrosion perform-ances of the four Mannich bases as inhibitors in 15%hydrochloric acid at 90℃were investigated by stat-ic gravimetric measurement and the polarization curves method .The four Mannich bases can be arranged ( in order of increasing anti-corrosion performance ):DPOMannich bases on the N 80 steel surface obey the Langmuir adsorption isotherm ,and the four Mannich bases can be arranged ( in order of increasing adsorbability ):DPOMannich bases could present preferable anti-corrosion performance when the conjugated system with rich electrons was formed between amino and phenyl in the Mannich bases .

  2. Halo Scraping, Diffusion and Repopulation MD

    CERN Document Server

    Valentino, G; Bruce, R; Burkart, F; Redaelli, F; Salvachua, B; Previtali, V; Stancari, G; Valishev, A

    2012-01-01

    Beam halo measurements in the LHC were conducted through collimator scrapings in an MD carried out on the 22nd June 2012 for the first time at 4 TeV. The time evolution of losses during a collimator scan provides information on halo diffusion and population. Four scans were performed with two collimators in the vertical and horizontal plane in B1 and B2 respectively, before and after bringing the beams into collisions. During an inward step, the beam losses measured at the BLMs for the first 3 seconds are believed to be dominated by multi-turn halo removal by the collimator jaw. However, a good comparison was found between fits of the diffusion model and the subsequent loss decay. In addition, the fitted diffusion coefficients compare well to the coefficients estimated from the core emittance growth rates as a function of action.

  3. Synthesis of Schiff and Mannich Bases of Isatin Derivatives with 4-Amino-4,5-Dihydro-1H-1,2,4-Triazole-5-Ones

    Directory of Open Access Journals (Sweden)

    Hakan Bektas

    2008-09-01

    Full Text Available Ethyl imidate hydrochlorides 1 were prepared by passing HCl gas through solutions of substituted benzyl cyanides and absolute ethanol. Ethoxycarbonylhydrazones 2 were synthesized from the reaction of compounds 1 with ethyl carbazate. Treatment of 2 with hydrazine hydrate leads to the formation of substituted 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones 3. Isatin and 5-chloroisatin were added to 3 to form Schiff bases 4 and N-Mannich bases 5 of these compounds were synthesized by reacting with formaldehyde and piperidine. Their chemical structures were confirmed by means of IR, 1H- and 13C-NMR data and by elemental analysis.

  4. Synthesis, Characterization, and Biological Activity of Novel Schiff and Mannich Bases of 4-Amino-3-(N-phthalimidomethyl-1,2,4-triazole-5-thione

    Directory of Open Access Journals (Sweden)

    Uzma Yunus

    2013-01-01

    Full Text Available The present work describes the syntheses and antimicrobial activity studies of a series of novel Schiff bases (4a–4i and their Mannich bases (5a–5h starting from 4-amino-3-(N-phthalimido-methyl-1,2,4-triazole-5-thione (3. All the synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR, and MS. All the synthesized compounds were screened for four Gram-negative strains, one Gram-positive strain of bacteria, and one diploid fungal strain. In general the antimicrobial activity increased remarkably on the introduction of azomethine functionality in parent triazole (3. The antimicrobial activity further improved when morpholine group was added to them except for Enterobacter cloacae, where loss of activity was observed. The results are promising and show that the fine tuning of the structures (5a, 5b, 5e, 5f, and 5h can lead to some new antimicrobial compounds.

  5. Cinchona Alkaloid Derivative-Catalyzed Enantioselective Synthesis via a Mannich-Type Reaction and Antifungal Activity of β-Amino Esters Bearing Benzoheterocycle Moieties

    Directory of Open Access Journals (Sweden)

    Han Xiao

    2014-04-01

    Full Text Available An efficient synthesis of highly functionalized chiral β-amino ester derivatives containing benzothiophene and benzothiazole moieties is developed by a Mannich-type reaction using a cinchona alkaloid-derived thiourea catalyst. The desired products were obtained in good yields and high enantioselectivities (~86% yield, >99% ee using to the optimized reaction conditions. The synthesized compounds were characterized by 1H-NMR, 13C-NMR, IR, and HREI-MS analyses. The bioassays identified that compound 5dr has excellent antifungal activity, with a 60.53% inhibition rate against F. oxysporum, higher than that of the commercial agricultural fungicide hymexazol, whose inhibition rate was 56.12%.

  6. Synthesis Characterization and Biological Activity Study of New Schiff and Mannich Bases and Some Metal Complexes Derived from Isatin and Dithiooxamide

    Directory of Open Access Journals (Sweden)

    Ahlam J. Abdulghani

    2011-01-01

    Full Text Available Two new Schiff and Mannich bases, namely, 1-Morpholinomethyl-3(1′ -N-dithiooxamideiminoisatin (LIH and 1-diphenylaminomethyl-3-1′-N-dithiooxamideiminoisatin (LIIH, were prepared from condensation reaction of new Schiff base 3-(1′-N-dithiooxamideiminoisatin (SBH with morpholine or diphenylamine respectively in presence of formaldehyde . The structures were characterized by IR, 1HNMR, mass spectrometry, and CHN analyses. Metal complexes of the two ligands were synthesized, and their structures were characterized by elemental analyses, atomic absorption, IR and UV-visible spectra, molar conductivity, and magnetic moment determination. All complexes showed octahedral geometries except palladium complexes which were square planar. The biological activity of the prepared compounds and some selected metal complexes was tested against three types of bacteria and against cell line of human epidermoid larynx carcinoma (Hep-2.

  7. 曼尼希碱环氧树脂固化剂的研究进展%Research development of Mannich base type epoxy resin curing agents

    Institute of Scientific and Technical Information of China (English)

    宋道理

    2011-01-01

    The synthesis principles and methods,the development history and tendency of Mannich base type epoxy resin curing agents were introduced in this paper.The technique of improving toughness and heat resistance, reducing viscosity of curing agents were descr%阐述了曼尼希碱型环氧树脂固化剂的合成原理、合成方法和发展历史与发展趋势,并就增加固化剂韧性、耐热性、降低固化剂黏度和开发水下固化剂以及改进固化剂生产工艺等方面进行了探讨。

  8. MD1228: Validation of Single Bunch Stability Threshold & MD1751: Instability Studies with a Single Beam

    CERN Document Server

    Carver, Lee Robert; Biancacci, Nicolo; Buffat, Xavier; Iadarola, Giovanni; Lasocha, Kacper; Li, Kevin Shing Bruce; Levens, Tom; Metral, Elias; Salvant, Benoit; Tambasco, Claudia; CERN. Geneva. ATS Department

    2017-01-01

    Instabilities were being routinely observed in B1V during ADJUST. The timing of the instabilities has been localised to shortly after the TOTEM bump has been implemented. The result is emittance blowup which can negatively effect the luminosity output of the fill. This MD aimed to rule out possible sources of the instability (i.e. beam-beam effects or electron cloud) by only taking one single beam to 6.5TeV and going through the full machine cycle. After the implementation of the TOTEM bump, a reduction of the octupole current was performed in order to determine if there was a discrepancy in the threshold between simulations and measurement. As a precursor, the results of the End of Fill MD: Validation of Single Bunch Stability Threshold will also be described.

  9. BI MD studies on April 22nd 2012 (LHC MD-1)

    CERN Document Server

    Baer, T; Boccardi, A; Burger, S; Calvo, E; Dehning, B; Emery, J; Gasior, M; Guerrero, A; Jones, R; Lefevre, T; Gras, JJ; Rabiller, A; Roncarolo, F; Sapinski, M; Steinhagen, R; Trad, G

    2012-01-01

    During the LHC MD block 1 in 2012, eight hours were dedicated to beam instrumentation studies. Such a period was spent mainly for estimating the betatron functions at the location of the transverse profile monitors in IR4 via the K-Modulation method and for characterizing the BSRT extraction mirror heating with high intensity beams. This note discusses the measurements summary, including some final and some preliminary results.

  10. MD5算法在Web开发中的应用%Application of MD5 in Web Exploitation

    Institute of Scientific and Technical Information of China (English)

    刘啸

    2014-01-01

    介绍了MD5加密技术在Web上的一些应用,给出了MD5加密实现密码在internet上安全传输的完整解决办法,给出了客户端(JavaScript)和服务器端(JavaBeans) MD5算法的实现.

  11. Legal briefing: conscience clauses and conscientious refusal.

    Science.gov (United States)

    Pope, Thaddeus Mason

    2010-01-01

    This issue's "Legal Briefing" column covers legal developments pertaining to conscience clauses and conscientious refusal. Not only has this topic been the subject of recent articles in this journal, but it has also been the subject of numerous public and professional discussions. Over the past several months, conscientious refusal disputes have had an unusually high profile not only in courthouses, but also in legislative and regulatory halls across the United States. Healthcare providers' own moral beliefs have been obstructing and are expected to increasingly obstruct patients' access to medical services. For example, some providers, on ethical or moral grounds, have denied: (1) sterilization procedures to pregnant patients, (2) pain medications in end-of-life situations, and (3) information about emergency contraception to rape victims. On the other hand, many healthcare providers have been forced to provide medical treatment that is inconsistent with their moral beliefs. There are two fundamental types of conscientious objection laws. First, there are laws that permit healthcare workers to refuse providing - on ethical, moral, or religious grounds healthcare services that they might otherwise have a legal or employer-mandated obligation to provide. Second, there are laws directed at forcing healthcare workers to provide services to which they might have ethical, moral, or religious objections. Both types of laws are rarely comprehensive, but instead target: (1) certain types of healthcare providers, (2) specific categories of healthcare services, (3) specific patient circumstances, and (4) certain conditions under which a right or obligation is triggered. For the sake of clarity, I have grouped recent legal developments concerning conscientious refusal into eight categories: 1. Abortion: right to refuse 2. Abortion: duty to provide 3. Contraception: right to refuse 4. Contraception: duty to provide 5. Sterilization: right to refuse 6. Fertility, HIV, vaccines

  12. BI MD studies on August 25th 2011

    CERN Document Server

    Belohrad, D; Boccardi, A; Calvo, E; Dehning, B; Favier, M; Emery, J; Guerrero, A; Lefevre, T; Gras, JJ; Jeff, A; Soby, L; Rabiller, A; Roncarolo, F; Sapinski, M; Steinhagen, R; Mateo, CM

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 25-Aug-2011 (from 5 a.m. to 1 p.m.), dedicated to study Beam Loss Monitors (BLM), Wire Scanners (WS), Synchrotron Radiation (BSRT), Beam Position Monitors (BPM), and Beam Gas Ionization (BGI) monitors. The MD aimed at performing different studies on the individual monitors.

  13. MD5密码极速爆破

    Institute of Scientific and Technical Information of China (English)

    飘零雪

    2009-01-01

    MD5加密技术对我们来说并不陌生,通过MD5值可以校验下载软件的安全性,而且在很多系统中,用户的密码是以MD5值的方式保存的,用户登录时系统是把用户输入的密码计算成MD5值,然后再去和系统中保存的MD5值进行比较,以验证该用户的合法性。MD5值虽看似很安全,但也并非无懈可击,使用“超速md5破解工具”即可简单快捷地尝试解密MD5。

  14. Single-block collision attack on MD5

    NARCIS (Netherlands)

    Stevens, M.M.J.

    2012-01-01

    In 2010, Tao Xie and Dengguo Feng \\cite{cryptoeprint:2010:643} constructed the first single-block collision for MD5 consisting of two 64-byte messages that have the same MD5 hash. Details of their attack, developed using what they call an evolutionary approach, has not been disclosed ``for security

  15. Chosen-Prefix Collisions for MD5 and Applications

    NARCIS (Netherlands)

    Stevens, M.M.J.; Lenstra, A.K.; Weger, B. de

    2012-01-01

    We present a novel, automated way to find differential paths for MD5. Its main application is in the construction of \\emph{chosen-prefix collisions}. We have shown how, at an approximate expected cost of $2^{39}$ calls to the MD5 compression function, for any two chosen message prefixes $P$ and $P'$

  16. 33 CFR 110.72 - Blackhole Creek, Md.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Blackhole Creek, Md. 110.72... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.72 Blackhole Creek, Md. The waters on the west side of Blackhole Creek, a tributary of Magothy River, southwest of a line bearing 310°30′ from the most...

  17. Waiting time distribution in M/D/1 queueing systems

    DEFF Research Database (Denmark)

    Iversen, Villy Bæk; Staalhagen, Lars

    1999-01-01

    The well-known formula for the waiting time distribution of M/D/1 queueing systems is numerically unsuitable when the load is close to 1.0 and/or the results for a large waiting time are required. An algorithm for any load and waiting time is presented, based on the state probabilities of M/D/1...

  18. Leroy D Vandam, MD: an anesthesia journey.

    Science.gov (United States)

    Ortega, Rafael A

    2005-08-01

    Leroy D Vandam, MD was a remarkable man--an intricate amalgamation of an artist, scientist, and physician. He was a bastion of medical historical knowledge. Dr Vandam became a most influential anesthesiologist, some say, a giant. He was an example of someone who, with resolve, overcame adversity. His artwork is displayed in countless places, and several of his paintings form part of the Wood Library Museum Heritage Series. Dr Vandam was first a surgeon, but he abandoned surgery and pursued a career in anesthesiology under the leadership of Robert Dripps. He completed his residency training at the University of Pennsylvania and joined its staff in 1949. When he arrived at Brigham and Women's Hospital in the 1950s as director of anesthesia, he embarked on one of the most illustrious careers in American anesthesiology. Dr Vandam published more than 250 original articles, chapters, abstracts, and other reports on a wide variety of subjects including history, art, and pharmacology. His classic article on the complications of neuroaxial blocks is a seminal work in anesthesiology. This article describes how an anesthesiologist who shared an interest with Dr Vandam in the history of anesthesiology came to produce a movie based on his career, the evolution of anesthesia equipment, and the transformation of our specialty.

  19. LHC MD 1279: Bunch Flattening in Physics

    CERN Document Server

    AUTHOR|(CDS)2073675; Baudrenghien, Philippe; Esteban Muller, Juan; Shaposhnikova, Elena; CERN. Geneva. ATS Department

    2017-01-01

    Vertex reconstruction is not accurate enough for LHCb when the bunch length in physics shrinks below about 0.9 ns. The end-of-fill MD studies presented here proved that bunch flattening using sinusoidal RF modulation is a loss-free method to increase the r.m.s. bunch length and flatten the bunch profile. Furthermore, the optimum modulation parameters to be used in physics have been identified. Subsequently, bunch flattening in physics was used operationally with a modulation frequency of 98.75 % of the central synchrotron frequency and 0.6 modulation amplitude, resulting in a 150-200 ps increase in the BQM-measured bunch length. A ‘mid-of-fill’ test at arrival to flat top revealed that also the bunch distribution created by the controlled emittance blow-up during the ramp is affected when bunch flattening is applied. The measurements took place on 17th June and the 4th, 7th and 22nd July 2016. Operational cases are shown as well.

  20. Orbit Feedback Operation with RCBX (MD 1209)

    CERN Document Server

    Wenninger, Jorg; Nisbet, David; Ponce, Laurette; Louro Alves, Diogo Miguel; CERN. Geneva. ATS Department

    2017-01-01

    The LHC Orbit Feedback (OFB) is able to drive any orbit corrector circuit (COD) to steer the LHC orbit. But during the first feedback tests in 2010, all attempts to use the common triplet orbit correctors (MCBX) failed because the QPS system installed to protect those magnets triggered power aborts as soon as the OFB steered the beam with those CODs. The reason was most likely the violation of the RCBX circuit acceleration limits. For this reason the MCBX orbit correctors were never driven by the OFB in regular operation. Although the performance of the OFB is generally excellent, the quality of the beam steering around IRs could be improved if the OFB could correct the orbit with the MCBX to counteract locally triplet quadrupole movements. The aim of this MD was to make a new attempt to use the MCBX in the OFB. The test was successful at injection (no circuit trip) and failed during the ramp (QPS power abort). The PC voltages and QPS Ures signals revealed the presence of voltage spikes with a period of 10~s...

  1. An easy stereoselective access to beta,gamma-aziridino alpha-amino ester derivatives via mannich reaction of benzophenone imines of glycine esters with N-sulfonyl alpha-chloroaldimines.

    Science.gov (United States)

    Kiss, Loránd; Mangelinckx, Sven; Sillanpää, Reijo; Fülöp, Ferenc; De Kimpe, Norbert

    2007-09-14

    Mannich-type addition of benzophenone imine glycinates across newly synthesized N-(p-toluenesulfonyl) alpha-chloroaldimines afforded gamma-chloro-alpha,beta-diamino ester derivatives with moderate diastereoselectivity as separable mixtures of anti and syn diastereomers. The gamma-chloro-alpha,beta-diamino esters were efficiently cyclized under basic conditions to the corresponding beta,gamma-aziridino alpha-amino ester derivatives, representing a new class of conformationally constrained heterocyclic alpha,beta-diamino acid derivatives. The relative configuration of the aziridines was determined via X-ray diffraction analysis. Mechanisms and intermediate transition states to explain the stereochemical outcome of the Mannich reaction with different substrates or under different conditions are proposed. The synthetic importance of the beta,gamma-aziridino alpha-amino ester derivatives is demonstrated by their conversion into the corresponding Boc-protected derivatives and ring opening reactions to alpha,beta-diamino esters and a gamma-amino alpha,beta-unsaturated amino ester.

  2. Asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes of glycine Schiff bases. Part 2: aldol, Mannich addition reactions, deracemization and (S) to (R) interconversion of α-amino acids.

    Science.gov (United States)

    Sorochinsky, Alexander E; Aceña, José Luis; Moriwaki, Hiroki; Sato, Tatsunori; Soloshonok, Vadim

    2013-11-01

    This review provides a comprehensive treatment of literature data dealing with asymmetric synthesis of α-amino-β-hydroxy and α,β-diamino acids via homologation of chiral Ni(II) complexes of glycine Schiff bases using aldol and Mannich-type reactions. These reactions proceed with synthetically useful chemical yields and thermodynamically controlled stereoselectivity and allow direct introduction of two stereogenic centers in a single operation with predictable stereochemical outcome. Furthermore, new application of Ni(II) complexes of α-amino acids Schiff bases for deracemization of racemic α-amino acids and (S) to (R) interconversion providing additional synthetic opportunities for preparation of enantiomerically pure α-amino acids, is also reviewed. Origin of observed diastereo-/enantioselectivity in the aldol, Mannich-type and deracemization reactions, generality and limitations of these methodologies are critically discussed.

  3. 77 FR 20598 - Defense Federal Acquisition Regulation Supplement: Solicitation Provisions and Contract Clauses...

    Science.gov (United States)

    2012-04-05

    ... clause 52.203-13, Contractor Code of Business Ethics and Conduct, including solicitations and contracts... clause when the only deliverable items are computer software or computer software documentation (see...

  4. 48 CFR 1827.305 - Administration of the patent rights clauses.

    Science.gov (United States)

    2010-10-01

    ... patent rights clauses. 1827.305 Section 1827.305 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights Under Government Contracts 1827.305 Administration of the patent rights clauses....

  5. PEG-OSO3H as an efficient and recyclable catalyst for the synthesis of β-amino carbonyl compounds via the Mannich reaction in PEG-H2O

    Institute of Scientific and Technical Information of China (English)

    Xi Cun Wang; Li Jia Zhang; Zhang Zhang; Zheng Jun Quan

    2012-01-01

    Sulfuric acid-modified polyethylene glycol 6000 (PEG-OSO3H) was applied as an efficient and recyclable catalyst for the synthesis of β-amino carbonyl compounds via the Mannich reaction between aldehydes,aromatic ketones and aromatic amines at room temperature using PEG400-H2O (1∶1) as environment-friendly solvents.The reactions were completed in short times and mild reaction conditions with good to excellent yields.

  6. Influence of sulfur physical properties in Claus unit operation

    Energy Technology Data Exchange (ETDEWEB)

    Larraz Mora, R.; Arvelo Alvarez, R. [Chemical Engineering Dept., Univ. of la Laguna, Tenerife (Spain)

    2002-09-01

    The Claus process is an efficient way of removing H{sub 2}S from acid gas streams and it has been widely practiced in industries such as natural gas processing, oil refining and metal smelting. Increasingly strict pollution control regulations require maximum sulfur recovery and high stream factor from the Claus units in order to minimize sulfur-containing effluents. As has been widely reported Claus unit's damages mainly occur during start up and shutdown. These operations involve scheduled warm-up and cool-down of the unit, usually burning refinery fuel-gas, which if not properly made can produce severe pipe and equipment plugging as well as catalyst deactivation. Sulfur products remaining in the unit during a shutdown period can produce dramatic unit corrosion episodes diminishing sulfur recovery unit stream factor. In the present paper some guidelines are given based on sulfur physical properties singularities which help to improve start-up/shut-down procedures. (orig.)

  7. Cyclic transfer in the derivation of Complete Parenthetical Clauses

    Directory of Open Access Journals (Sweden)

    Alba Cerrudo Aguilar

    2016-06-01

    Full Text Available The goal of this paper is to show that some parentheticals are indeed syntactic orphans (cf. Haegeman 1988 and that this intuition can be formalized using tools independently motivated in linguistic theory. We concentrate on new data regarding clitic realization in what are commonly called Reduced Parenthetical Clauses (RPCs. We show that these constructions with clitic differ of their reduced counterpart in many aspects; crucially, they behave as root domains. Thus, we argue that they are derived independently from the host clause (in a parallel workspace and their linear interpolation occurs during the Spell-Out process, assuming a dynamic version of cyclic Transfer (cf. Chomsky 2001, Uriagereka 1999.

  8. 48 CFR 1649.101-71 - FEHBP termination for convenience clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true FEHBP termination for convenience clause. 1649.101-71 Section 1649.101-71 Federal Acquisition Regulations System OFFICE OF PERSONNEL... CONTRACTS General Principles 1649.101-71 FEHBP termination for convenience clause. The clause set forth...

  9. 78 FR 11188 - General Services Administration Regulation; Submission for OMB Review; Packing List Clause

    Science.gov (United States)

    2013-02-15

    ... ADMINISTRATION General Services Administration Regulation; Submission for OMB Review; Packing List Clause AGENCY... packing list clause. A notice was published in the Federal Register at 77 FR 66466, on November 5, 2012...: Submit comments identified by Information Collection 3090- 0246, Packing List Clause, by any of...

  10. Syntactic and Semantic Coordination in Finite Complement-Clause Constructions: A Diary-Based Case Study

    Science.gov (United States)

    Köymen, Bahar; Lieven, Elena; Brandt, Silke

    2016-01-01

    This study investigates the coordination of matrix and subordinate clauses within finite complement-clause constructions. The data come from diary and audio recordings which include the utterances produced by an American English-speaking child, L, between the ages 1;08 and 3;05. We extracted all the finite complement-clause constructions that L…

  11. MD-PhD training: looking back and looking forward.

    Science.gov (United States)

    Bonham, Ann C

    2014-01-01

    MD-PhD programs provide rigorous, integrated training for physician-scientists, enabling them to frame scientific questions in unique ways and to apply clinical insight to fundamental science. Few would question the influential contributions of MD-PhD physician-scientists in advancing medical science. In this issue of Academic Medicine, Jeffe et al affirm high levels of excellence in educational outcomes from MD-PhD training programs at U.S. MD-granting medical schools, especially programs that receive funding from the NIH Medical Scientist Training Program (MSTP). The author of this commentary observes that, in the face of current economic pressures, comprehensive, longitudinal national outcomes data from MSTP- and non-MSTP-funded MD-PhD programs will help verify the value provided by MD-PhD physician-scientists. She proposes that MD-PhD programs should better prepare the next generation of physician-scientists for future research environments, which will provide new technologies, venues, and modalities. These research environments will be more closely integrated within health care delivery systems, extend into diverse communities and regions, and employ complex technologies. MD-PhD physician-scientists also will train and gain expertise in broadening areas of research, such as health policy, health economics, clinical epidemiology, and medical informatics. Program leaders are ideally situated to foster innovative learning environments and methodologies. By sharing their innovations, they can help ensure production of a diverse MD-PhD physician-scientist workforce, prepared to engage in myriad research opportunities to meet patient and population needs in a new environment.

  12. MD5加密算法的研究

    Institute of Scientific and Technical Information of China (English)

    许琪

    2014-01-01

    MD5加密算法做为散列函数的一个重要算法,在文件校验、数字签名等诸多领域有着广泛的应用.虽然MD5加密算法是单向算法,但其仍无法抵御差分攻击和查字典攻击.文章在分析了差分攻击原理的基础上,阐述了MD5加密算法采用差分攻击产生碰撞的方法.

  13. The Achromatic Telescopic Squeezing (ATS) MD part III

    CERN Document Server

    Fartoukh, S; Goddard, B; Hofle, W; Jacquet, D; Kruk, G; Lamont, M; de Maria, R; Miyamoto, R; Mueller, G; Pojer, M; Ponce, L; Redaelli, S; Ryckx, N; Steinhagen, R; Strzelczyk, M; Vanbavinckhove, G; Wenninger, J

    2011-01-01

    This note highlights the results obtained during the third so-called ATS MD which took place in 2011. The goal of this MD was extremely challenging, targeting a pre-squeezed beta* of 40 cm in ATLAS and CMS, followed by a telescopic squeeze of these two insertions to finally reach a beta* of 10 cm both at IP1 and IP5. Due to the rather poor machine availability during the MD period, the time initially allocated to the ATS studies was hardly cut by a factor of 2, and "only" the achromatic pre-squeeze down to beta*=40 cm was demonstrated with beam.

  14. MD5Hash加密算法在SQL Server2005中的应用%Application of MD5 Hash Encryption Algorithm in SQL Server 2005

    Institute of Scientific and Technical Information of China (English)

    李红日

    2011-01-01

    在对MD5算法进行简要描述的同时,对MD5算法的原理作深入分析.介绍在C创建MD5 Hash算法的函数,在SQL Server中应用MD5哈希算法,并且经过测试可以准确实现MD5 Hash加密算法.

  15. THE EFFICACY OF THE ARBITRATION CLAUSE IN A SIMULATED ACT

    Directory of Open Access Journals (Sweden)

    Tudor Vlad RĂDULESCU

    2016-05-01

    Full Text Available The article focuses on the effects that an arbitration clause can still produce when it is contained in a simulated operation, whether it is in the apparent act or in the secret one, depending on the forms of simulation.

  16. 48 CFR 904.404 - Solicitation provision and contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Solicitation provision and contract clause. 904.404 Section 904.404 Federal Acquisition Regulations System DEPARTMENT OF ENERGY... DOE's security authority is derived from the Atomic Energy Act which contains specific language...

  17. 12 CFR 34.5 - Due-on-sale clauses.

    Science.gov (United States)

    2010-01-01

    ... and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY REAL ESTATE LENDING AND APPRAISALS... State law limitations to the contrary. For the purposes of this section, the term real property includes..., secured by a lien on real property, that includes a due-on-sale clause. Except as set forth in 12...

  18. From Sound to Syntax: The Prosodic Bootstrapping of Clauses

    Science.gov (United States)

    Hawthorne, Kara

    2013-01-01

    It has long been argued that prosodic cues may facilitate syntax acquisition (e.g., Morgan, 1986). Previous studies have shown that infants are sensitive to violations of typical correlations between clause-final prosodic cues (Hirsh-Pasek et al., 1987) and that prosody facilitates memory for strings of words (Soderstrom et al., 2005). This…

  19. U.S. Foreign Medical Students: After the "Guadalajara Clause"

    Science.gov (United States)

    Walsh, John

    1977-01-01

    The controversial issues surrounding the "Guadalajara Clause" of the Health Professions Educational Assistance Act of 1976 are detailed. At issue is whether Americans studying in foreign medical schools should be admitted to third and fourth year classes if they can pass part one of the National board examinations. (BT)

  20. Word order variation and foregrounding of complement clauses

    DEFF Research Database (Denmark)

    Christensen, Tanya Karoli; Jensen, Torben Juel

    2015-01-01

    Through mixed models analyses of complement clauses in a corpus of spoken Danish we examine the role of sentence adverbials in relation to a word order distinction in Scandinavian signalled by the relative position of sentence adverbials and finite verb (V>Adv vs. Adv>V). The type of sentence...

  1. 37 CFR 401.5 - Modification and tailoring of clauses.

    Science.gov (United States)

    2010-07-01

    ..., DEPARTMENT OF COMMERCE RIGHTS TO INVENTIONS MADE BY NONPROFIT ORGANIZATIONS AND SMALL BUSINESS FIRMS UNDER... business firm or nonprofit organization that it would be in the national interest to acquire the right to... may delete paragraph (g)(2) of the clause and delete the words “to be performed by a small...

  2. 45 CFR 650.4 - Standard patent rights clause.

    Science.gov (United States)

    2010-10-01

    ... special patent clause has been negotiated (see § 650.5). Patent Rights (August, 2005) (a) Definitions—(1) Invention means any invention or discovery which is or may be patentable or otherwise protectable under... Plant Variety Protection Act (7 U.S.C. 2321 et seq.). (2) Subject invention means any invention of...

  3. Processing Relative Clauses in Chinese as a Second Language

    Science.gov (United States)

    Xu, Yi

    2014-01-01

    This project investigates second language (L2) learners' processing of four types of Chinese relative clauses crossing extraction types and demonstrative-classifier (DCl) positions. Using a word order judgment task with a whole-sentence reading technique, the study also discusses how psycholinguistic theories bear explanatory power in L2 data. An…

  4. 48 CFR 27.409 - Solicitation provisions and contract clauses

    Science.gov (United States)

    2010-10-01

    ... a clause providing for less than unlimited right has been authorized (see 27.408). (2) If an agency..., etc. may include limitations in connection with talent releases, music licenses, and the like that are... desires to acquire unlimited rights in technical data contained in a successful proposal upon which...

  5. 48 CFR 3004.470-3 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... to Government facilities or access to sensitive information. Contracting Officers shall insert the... contractor employee access to sensitive information or Government facilities must be limited to U.S. citizens... recurring access to Government facilities or access to sensitive information. Neither the basic clause...

  6. 48 CFR 22.810 - Solicitation provisions and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... insert the provision at 52.222-25, Affirmative Action Compliance, in solicitations, other than those for... clause at 52.222-27, Affirmative Action Compliance Requirements for Construction, in solicitations and... provision at 52.222-22, Previous Contracts and Compliance Reports, in the solicitation. (b) The...

  7. THE EFFICACY OF THE ARBITRATION CLAUSE IN A SIMULATED ACT

    Directory of Open Access Journals (Sweden)

    Tudor Vlad RĂDULESCU

    2016-12-01

    Full Text Available The article focuses on the effects that an arbitration clause can still produce when it is contained in a simulated operation, whether it is in the apparent act or in the secret one, depending on the forms of simulation.

  8. 48 CFR 3437.270 - Consulting services reporting clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Consulting services reporting clause. 3437.270 Section 3437.270 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING SERVICE CONTRACTING Consulting Services...

  9. 48 CFR 3437.271 - Services of consultants clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Services of consultants clause. 3437.271 Section 3437.271 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING SERVICE CONTRACTING Consulting Services...

  10. 48 CFR 970.2702 - Patent related clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Patent related clauses. 970.2702 Section 970.2702 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Patents, Data, and Copyrights 970.2702...

  11. 48 CFR 3027.305 - Administration of Patent Rights Clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Administration of Patent... SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) SOCIOECONOMIC PROGRAMS PATENTS, DATA, AND COPYRIGHTS Patent Rights under Government Contracts 3027.305 Administration of Patent Rights Clauses....

  12. The Acquisition of Chinese Relative Clauses: Contrasting Two Theoretical Approaches

    Science.gov (United States)

    Hu, Shenai; Gavarró, Anna; Vernice, Mirta; Guasti, Maria Teresa

    2016-01-01

    This study examines the comprehension of relative clauses by Chinese-speaking children, and evaluates the validity of the predictions of the Dependency Locality Theory (Gibson, 1998, 2000) and the Relativized Minimality approach (Friedmann, Belletti & Rizzi, 2009). One hundred and twenty children from three to eight years of age were tested by…

  13. Interpolant tree automata and their application in Horn clause verification

    DEFF Research Database (Denmark)

    Kafle, Bishoksan; Gallagher, John Patrick

    2016-01-01

    This paper investigates the combination of abstract interpretation over the domain of convex polyhedra with interpolant tree automata, in an abstraction-refinement scheme for Horn clause verification. These techniques have been previously applied separately, but are combined in a new way in this ...... clause verification problems indicates that the combination of interpolant tree automaton with abstract interpretation gives some increase in the power of the verification tool, while sometimes incurring a performance overhead.......This paper investigates the combination of abstract interpretation over the domain of convex polyhedra with interpolant tree automata, in an abstraction-refinement scheme for Horn clause verification. These techniques have been previously applied separately, but are combined in a new way...... in this paper. The role of an interpolant tree automaton is to provide a generalisation of a spurious counterexample during refinement, capturing a possibly infinite set of spurious counterexample traces. In our approach these traces are then eliminated using a transformation of the Horn clauses. We compare...

  14. 48 CFR 25.1103 - Other provisions and clauses.

    Science.gov (United States)

    2010-10-01

    ... SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Solicitation Provisions and Contract Clauses 25.1103 Other provisions..., in solicitations and contracts if anticipating translation into another language. (c) Foreign... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Other provisions...

  15. Asymmetry in Temporal and Sequential Clauses in Chinese

    Science.gov (United States)

    Chan, Stephen W.

    1974-01-01

    Examines several subtypes of the verbal sequency NP-VP1-VP2 in Chinese, especially those involving descriptions of human action, directed motion, and instrumental functions, and finds that these could be subsumed under the heading of "purposive clauses." The VP1 states an action whose goal is fulfilled by the action performed in VP2. (Author/RM)

  16. 48 CFR 235.072 - Additional contract clauses.

    Science.gov (United States)

    2010-10-01

    ... involving research on live vertebrate animals. (b) Use the clause at 252.235-7003, Frequency Authorization... 252.235-7011, Final Scientific or Technical Report, in solicitations and contracts for research and... SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING...

  17. Molecular Dynamics Simulations and XAFS (MD-XAFS)

    Energy Technology Data Exchange (ETDEWEB)

    Schenter, Gregory K.; Fulton, John L.

    2017-01-20

    MD-XAFS (Molecular Dynamics X-ray Adsorption Fine Structure) makes the connection between simulation techniques that generate an ensemble of molecular configurations and the direct signal observed from X-ray measurement.

  18. Research of the Hash Algorithm Based on MD5%MD5散列算法的研究

    Institute of Scientific and Technical Information of China (English)

    姜学军; 曹烨

    2014-01-01

    借鉴了M.M.J.Stevens的碰撞思路,重新编写了MD5碰撞算法中的核心循环,主要提供一对MD5碰撞产生的过程以及碰撞的完成.通过实验统计分析,利用改进的MD5碰撞算法找到一对碰撞信息所用平均时间不多于60s,且该算法较之传统的MD5碰撞算法具有更好的可读性和可移植性.

  19. 基于MD5和Session的PHP安全防范%PHP security based on Session and MD5

    Institute of Scientific and Technical Information of China (English)

    何秉荣

    2014-01-01

    根据Session工作原理和MD5算法的特性,分析了PHP中Session欺骗与攻击手段,并较有针对性地在防范Session攻击的技术中结合MD5函数,从而提出了一个较为有效、实用的防范措施.

  20. Claus plant tail gas treatment; Traitement des gaz de queue du procede claus

    Energy Technology Data Exchange (ETDEWEB)

    Lavalley, J.C.; Laperdrix, E. [Institut des Sciences de la Matiere et du Rayonnement, UMR 6506, Lab. Catalyse et Spectrochimie, 14 - Caen (France); Universite Chouaib Doukali, Faculte des Sciences, Lab. de Chimie Physique, El Jadida (Morocco)

    2002-07-01

    Tail gas of Claus plants generally contains COS, CS{sub 2} and H{sub 2}S. In order to satisfy the new environmental requirements, COS and CS{sub 2} hydrolysis have to be improved, whereas the oxidation of H{sub 2}S in sulfur, S{sub n}, appears to be one of the most satisfactory processes for the removal of slight amounts of H{sub 2}S. IR studies evidence that sulfate species are reduced by H{sub 2}S at 320 deg C on TiO{sub 2}, contrary to results obtained on Al{sub 2}O{sub 3}, explaining why TiO{sub 2} is much more effective than alumina when the CS{sub 2} + H{sub 2}O feed also contains H{sub 2}S and O{sub 2} traces. A CuO/Al{sub 2}O{sub 3} catalyst was used for selective oxidation of H{sub 2}S into sulfur at 110 deg C. It is shown that polysulfide species are formed during the reaction, constituting an uniqueness of this catalyst. Elemental sulfur appears from the cleavage of too-long polysulfide chains. Storage of sulfur in the catalyst porosity provokes its deactivation whereas the catalyst ability to form sulfate species is poor. (author)

  1. Synthesis, growth, optical and DFT calculation of 2-naphthol derived Mannich base organic non linear optical single crystal for frequency conversion applications

    Science.gov (United States)

    Raj, A. Dennis; Jeeva, M.; Shankar, M.; Purusothaman, R.; Prabhu, G. Venkatesa; Potheher, I. Vetha

    2016-11-01

    2-naphthol derived Mannich base 1-((4-methylpiperazin-1-yl) (phenyl) methyl) naphthalen-2-ol (MPN) - a nonlinear optical single crystal was synthesized and successfully grown by slow evaporation technique at room temperature. The molecular structure was confirmed by single crystal XRD, FT-IR, 1H NMR and 13C NMR spectral studies. The single crystal X-ray diffraction analysis reveals that the crystal belongs to orthorhombic crystal system with non-centrosymmetric space group Pna21. The chemical shift of 5.34 ppm (singlet methine CH proton) in 1H NMR and signal for the CH carbon around δ70.169 ppm in 13C NMR confirms the formation of the title compound. The crystal growth pattern and dislocations of crystal are analyzed using chemical etching technique. UV cut off wavelength of the material was found to be 212 nm. The second harmonic generation (SHG) of MPN was determined from Kurtz Perry powder technique and the efficiency is almost equal to that of standard KDP crystal. The laser damage threshold was measured by passing Nd: YAG laser beam through the sample and it was found to be 1.1974 GW/cm2. The material was thermally stable up to 142 °C. The relationship between the molecular structure and the optical properties was also studied from quantum chemical calculations using Density Functional Theory (DFT) and reported for the first time.

  2. Cummins MD & HD Accessory Hybridization CRADA -Annual Report FY15

    Energy Technology Data Exchange (ETDEWEB)

    Deter, Dean D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-10-01

    There are many areas of MD and HD vehicles that can be improved by new technologies and optimized control strategies. Component optimization and idle reduction need to be addressed, this is best done by a two part approach that includes selecting the best component technology, and/or architecture, and optimized controls that are vehicle focused. While this is a common focus in the light duty industry it has been gaining momentum in the MD and HD market as the market gets more competitive and the regulations become more stringent. When looking into systems optimization and idle reduction technologies, affected vehicle systems must first be considered, and if possible included in the new architecture to get the most benefit out of these new capabilities. Typically, when looking into idle reduction or component optimization for MD/HD, the vehicle s accessories become a prime candidate for electrification or hybridization. While this has already been studied on light duty vehicles (especially on hybrids and electric vehicles) it has not made any head way or market penetration in most MD and HD applications. If hybrids and electric MD and HD vehicles begin to break into the market this would be a necessary step into the ability to make those vehicles successful by allowing for independent, optimized operation separate from the engine.

  3. Processing relative clauses by Hungarian typically developing children.

    Science.gov (United States)

    Kas, Bence; Lukács, Agnes

    2012-05-01

    Hungarian is a language with morphological case marking and relatively free word order. These typological characteristics make it a good ground for testing the crosslinguistic validity of theories on processing sentences with relative clauses. Our study focussed on effects of structural factors and processing capacity. We tested 43 typically developing children in two age groups (ages of 4;11-7;2 and 8;2-11;4) in an act-out task. Differences in comprehension difficulty between different word order patterns and different head function relations were observed independently of each other. The structural properties causing difficulties in comprehension were interruption of main clauses, greater distance between the verb and its arguments, accusative case of relative pronouns, and SO head function relations. Importantly, analyses of associations between working memory and sentence comprehension revealed that structural factors made processing difficult by burdening components of working memory. These results support processing accounts of sentence comprehension in a language typologically different from English.

  4. The acquisition of mood selection in Spanish relative clauses.

    Science.gov (United States)

    Pérez-Leroux, A T

    1998-10-01

    Although children acquire Spanish subjunctive morphology early in the process of language acquisition, they only master mood selection in a staged process that lasts for several years. This paper examines the possibility that the acquisition of subjunctive mood selection in particular syntactic contexts is constrained by cognitive development in the area of representational theory of mind. Acquisition of the epistemic aspects of the semantics of subjunctive are shown to be associated with the understanding of false beliefs, a landmark development in children's cognition. Twenty-two Spanish speaking children between the ages of 3;5 and 6;11 participated in an elicited production study designed to test whether children's ability to produce subjunctive relative clauses was related to their ability to pass a false belief task. Results indicate a strong correlation between children's ability to use the subjunctive mood in relative clauses and their capacity for understanding false beliefs.

  5. A new clause to the Sexual Contract: surrogate pregnancies

    Directory of Open Access Journals (Sweden)

    Laura Nuño Gómez

    2016-12-01

    Full Text Available This article addresses the debate on the regulation of commercial pregnancies as a revision on the market’s demand and under the fallacy of free will, incorporates a new clause to the Sexual Contract. This debate requires that we analyse the limits of commodification on the one hand and on the other, the ethical requisites of referring to free will in a globalized context of feminization of poverty, sexual inequality and the rearmament of patriarchal neoliberalism.

  6. Development of Relative Clause Constructions in English L2

    Directory of Open Access Journals (Sweden)

    Yumiko Yamaguchi

    2016-01-01

    Full Text Available This study explores how relative clause (RC constructions develop in the acquisition of English as a second language (L2. The acquisition of RC constructions has been the focus of much research in the field of language acquisition, but a majority of L2 studies in this area is experimental based on the Noun Phrase Accessibility Hierarchy (NPAH (Keenan & Comrie, 1977. In this study, the spontaneous speech production by a Japanese primary school child, learning English in a naturalistic environment, was audio-recorded regularly over two years, and the development of RC constructions was compared with the acquisition of other English morphological and syntactic structures as represented within Processability Theory (PT (Pienemann, 1998; Pienemann, Di Biase, & Kawaguchi, 2005; Pienemann & Keßler, 2011. Although PT predicts that subordinate clauses are acquired at the highest stage in processability hierarchy, the results in this longitudinal study show that some types of RC constructions emerge at earlier stages in L2 English acquisition. The results also show that RC constructions in the Japanese child’s English L2 develop in the similar way to those reported in L1 studies (e.g., Diessel, 2004.Keywords: relative clause constructions, English L2, Processability Theory, the Noun Phrase Accessibility Hierarchy, Japanese child

  7. CoMD Implementation Suite in Emerging Programming Models

    Energy Technology Data Exchange (ETDEWEB)

    2014-09-23

    CoMD-Em is a software implementation suite of the CoMD [4] proxy app using different emerging programming models. It is intended to analyze the features and capabilities of novel programming models that could help ensure code and performance portability and scalability across heterogeneous platforms while improving programmer productivity. Another goal is to provide the authors and venders with some meaningful feedback regarding the capabilities and limitations of their models. The actual application is a classical molecular dynamics (MD) simulation using either the Lennard-Jones method (LJ) or the embedded atom method (EAM) for primary particle interaction. The code can be extended to support alternate interaction models. The code is expected ro run on a wide class of heterogeneous hardware configurations like shard/distributed/hybrid memory, GPU's and any other platform supported by the underlying programming model.

  8. 基于C#的MD5加密算法的应用%Application of the MD5 algorithm based on C#

    Institute of Scientific and Technical Information of China (English)

    林宗朝

    2011-01-01

    介绍了WEB SYSTEM中的密钥安全性能。主要讨论了WEB SYSTEM中MD5加密算法,包含客户password安全性分析、MD5加密算法概述、基于C#的MD5加密应用介绍,以及IT SYSTEM中MD5算法的应用与IMPROVEMENT等问题。%The key safety properties of the WEB system is described,and the.MD5 encryption algorithm is discussed mainly including the user password security analysis,MD5 encryption algorithm summary,MD5 encryption applications based on the C# and the improvement of MD5 algorithm.

  9. Tree automata-based refinement with application to Horn clause verification

    DEFF Research Database (Denmark)

    Kafle, Bishoksan; Gallagher, John Patrick

    2015-01-01

    underlying the Horn clauses. Experiments using linear constraint problems and the abstract domain of convex polyhedra show that the refinement technique is practical and that iteration of abstract interpretation with tree automata-based refinement solves many challenging Horn clause verification problems. We......In this paper we apply tree-automata techniques to refinement of abstract interpretation in Horn clause verification. We go beyond previous work on refining trace abstractions; firstly we handle tree automata rather than string automata and thereby can capture traces in any Horn clause derivations...... rather than just transition systems; secondly, we show how algorithms manipulating tree automata interact with abstract interpretations, establishing progress in refinement and generating refined clauses that eliminate causes of imprecision. We show how to derive a refined set of Horn clauses in which...

  10. Horn clause verification with convex polyhedral abstraction and tree automata-based refinement

    DEFF Research Database (Denmark)

    Kafle, Bishoksan; Gallagher, John Patrick

    2017-01-01

    underlying the Horn clauses. Experiments using linear constraint problems and the abstract domain of convex polyhedra show that the refinement technique is practical and that iteration of abstract interpretation with tree automata-based refinement solves many challenging Horn clause verification problems. We......In this paper we apply tree-automata techniques to refinement of abstract interpretation in Horn clause verification. We go beyond previous work on refining trace abstractions; firstly we handle tree automata rather than string automata and thereby can capture traces in any Horn clause derivations...... rather than just transition systems; secondly, we show how algorithms manipulating tree automata interact with abstract interpretations, establishing progress in refinement and generating refined clauses that eliminate causes of imprecision. We show how to derive a refined set of Horn clauses in which...

  11. Restructuring the syllabus for MD Pharmacology: Retrospection of bioassay

    Directory of Open Access Journals (Sweden)

    Sarita Mulkalwar

    2014-01-01

    Full Text Available Introduction: Career prospects in Pharmacology are witnessing a sea change due to fast and unanticipated development in the field of clinical research. Numerous openings exist now in academia, pharmaceutical industry, Clinical Research Organizations (CRO or as regulatory consultants, experimental pharmacologists, etc. In short, there are various options to choose from, depending on one′s interest. It′s high time we ponder now over the training programme for post-graduate students in Pharmacology. It needs to be revised keeping in mind the job prospects & uniqueness of the MD Pharmacology degree. Aim: To take suggestions of experienced pharmacologists on the present syllabus for MD Pharmacology and their opinion on continuation of Bioassay experiment which is currently an important part of it . Materials and Methods: A structured questionnaire was given to 30 experienced pharmacologists to seek their opinion on MD Pharmacology syllabus & continuation of Bioassay as a part of MD practical. Results: Out of 30 participants, 29 (96.6% did not use their knowledge of Bioassay during their 10 years of post MD career, whether in pharmaceutical industry or in academics. Only 5 of them (16.6% feel that experiment on bioassay should be continued in the current state. 76.7% of them wish it to be modified to a Dose Response Curve ( DRC . 6.71% feel that it should be totally scrapped. All the participants feel the need of revising current MD Pharmacology syllabus. Current syllabus is inclined more towards preparing good academicians but it lacks the proper training for creating good clinical research professionals. Medical writing, writing necessary documents for clinical trials including regulatory documents, writing an article for medical journals, marketing communication, product monograph and patient information of a clinical trial could be incorporated. They should be aware of the regulatory requirements for conducting studies on investigational drugs

  12. BayesMD: flexible biological modeling for motif discovery

    DEFF Research Database (Denmark)

    Tang, Man-Hung Eric; Krogh, Anders; Winther, Ole

    2008-01-01

    We present BayesMD, a Bayesian Motif Discovery model with several new features. Three different types of biological a priori knowledge are built into the framework in a modular fashion. A mixture of Dirichlets is used as prior over nucleotide probabilities in binding sites. It is trained on trans......We present BayesMD, a Bayesian Motif Discovery model with several new features. Three different types of biological a priori knowledge are built into the framework in a modular fashion. A mixture of Dirichlets is used as prior over nucleotide probabilities in binding sites. It is trained...

  13. BI MD Studies on June 29th 2011

    CERN Document Server

    Belohrad, D; Bravin, E; Calvo, E; Dehning, B; Emery, J; Favier, M; Gras, JJ; Guerrero, A; Jeff, A; Lefevre, T; Rabiller, A; Roncarolo, F; Sapinski, M; Soby, L; Steinhagen, R

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 29-June-2011 (from 10 p.m. to 07 a.m.), dedicated to study Beam Current Monitors (BCT), Wire Scaners (WS), Synchrotron Radiation (BSRT), Beam Position (BPM), Wall Current (WCM) and Beam Gas Ionization (BGI) monitors. The MD aimed at performing different studies on the individual monitors. At the same time, it was possible to perform calibration studies with the Abort Gap (AGM) and Longitudinal Density (LDM) monitors that share the extracted light with the BSRT. Additionally some observations about the beam stability and emittance dependence on the chromaticity were performed.

  14. Improved Collision Attack on Hash Function MD5

    Institute of Scientific and Technical Information of China (English)

    Jie Liang; Xue-Jia Lai

    2007-01-01

    In this paper, we present a fast attack algorithm to find two-block collision of hash function MD5.The algorithm is based on the two-block collision differential path of MD5 that was presented by Wang et al.In the Conference EUROCRYPT 2005.We found that the derived conditions for the desired collision differential path were not sufficient to guarantee the path to hold and that some conditions could be modified to enlarge the collision set.By using technique of small range searching and omitting the computing steps to check the characteristics in the attack algorithm, we can speed up the attack of MD5 efficiently.Compared with the Advanced Message Modification technique presented by Wang et al.,the small range searching technique can correct 4 more conditions for the first iteration differential and 3 more conditions for the second iteration differential, thus improving the probability and the complexity to find collisions.The whole attack on the MD5 can be accomplished within 5 hours using a PC with Pentium4 1.70GHz CPU.

  15. MD SIMULATION OF SUBTILISIN BPN' IN A CRYSTAL ENVIRONMENT

    NARCIS (Netherlands)

    HEINER, AP; BERENDSEN, HJC; VANGUNSTEREN, WF

    1992-01-01

    In this paper we present a molecular dynamics (MD) simulation of subtilisin BPN' in a crystalline environment containing four protein molecules and solvent. Conformational and dynamic properties of the molecules are compared with each other and with respect to the X-ray structure to test the validit

  16. Physical Properties of Near-Earth Asteroid 2011 MD

    NARCIS (Netherlands)

    Mommert, M.; Farnocchia, D.; Hora, J. L.; Chesley, S. R.; Trilling, D. E.; Chodas, P. W.; Mueller, M.; Harris, A. W.; Smith, H. A.; Fazio, G. G.

    2014-01-01

    We report on observations of near-Earth asteroid 2011 MD with the Spitzer Space Telescope. We have spent 19.9 h of observing time with channel 2 (4.5 {\\mu}m) of the Infrared Array Camera and detected the target within the 2{\\sigma} positional uncertainty ellipse. Using an asteroid thermophysical mod

  17. 77 FR 73967 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Science.gov (United States)

    2012-12-12

    ... Regulation; Bear Creek, Dundalk, MD'' in the Federal Register (77 FR 5201). The rulemaking concerned would... proposed rulemaking the bridge owner displayed on the Wise Avenue Bridge signage that stated a 48-hour advance notice was required to open the draw bridge. This signage portrayed improper...

  18. 78 FR 65180 - Airworthiness Directives; MD Helicopters, Inc., Helicopters

    Science.gov (United States)

    2013-10-31

    ... condition, vibration, loss of tail rotor pitch control, and loss of directional control of the helicopter...-047-AD; Amendment 39-17606; AD 2013-19-24] RIN 2120-AA64 Airworthiness Directives; MD Helicopters, Inc., Helicopters AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We...

  19. 78 FR 27867 - Airworthiness Directives; MD Helicopters Inc. Helicopters

    Science.gov (United States)

    2013-05-13

    ..., leading to vibration, loss of tail rotor pitch control, and subsequent loss of tail rotor and helicopter... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; MD Helicopters Inc. Helicopters AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking...

  20. QM/MM-MD simulations of conjugated polyelectrolytes

    DEFF Research Database (Denmark)

    Sjöqvist, Jonas; Linares, Mathieu; Mikkelsen, Kurt Valentin

    2014-01-01

    description of the solvent in its electronic ground state as well as the chromophore in its electronic ground and excited states, (ii) a conformational sampling by means of classical molecular dynamics (MD) in the respective electronic states, and (iii) spectral response calculations by means of the quantum...

  1. Biomolecular recognition mechanisms studied by NMR spectroscopy and MD simulations

    NARCIS (Netherlands)

    Hsu, Shang-Te Danny

    2004-01-01

    This thesis describes the use of solution Nuclear Magnetic Resonance (NMR) spectroscopy and Molecular Dynamics (MD) simulations to study the mechanism of biomolecular recognition with two model systems: i) lipid II-binding lantibiotics (lanthionine-containing antibiotics) and ii) the human immunodef

  2. 77 FR 12476 - Drawbridge Operation Regulation; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2012-03-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Curtis Creek, Baltimore..., across Curtis Creek, mile 1.0, at Baltimore, MD. This deviation allows the bridge to operate on...

  3. 75 FR 54069 - Drawbridge Operation Regulations; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2010-09-03

    ... (75 FR 30747-30750). The rulemaking concerned eliminating the need for a bridge tender by allowing the... SECURITY Coast Guard 33 CFR Part 117 RIN 1625--AA09 Drawbridge Operation Regulations; Curtis Creek... Avenue Bridge, at mile 0.9, across Curtis Creek at Baltimore, MD. The requested change would have...

  4. 76 FR 9225 - Drawbridge Operation Regulation; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2011-02-17

    ... Regulations; Curtis Creek, Baltimore, MD'' in the Federal Register (74 FR 50707). The temporary deviation... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Curtis Creek, Baltimore... changing the drawbridge operation regulations of the Pennington Avenue Bridge, across Curtis Creek, mile...

  5. 75 FR 1705 - Drawbridge Operation Regulations; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2010-01-13

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulations; Curtis Creek... operation of the I695 Bridge across Curtis Creek, mile 0.9, at Baltimore, MD. The deviation is necessary to... section of Curtis Creek and the bridge will not be able to open in the event of an emergency. Coast...

  6. 75 FR 50707 - Drawbridge Operation Regulation; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2010-08-17

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Curtis Creek, Baltimore... operation of the Pennington Avenue Bridge, across Curtis Creek, mile 0.9, at Baltimore, MD. This deviation... vessels bound for the Coast Guard Yard at Curtis Bay, as well as a significant amount of commercial...

  7. Antimalarial activity of Mannich bases derived from 4-(7'-bromo-1',5'-naphthyridin-4'-ylamino)phenol and 4-(7'-trifluoromethylquinolin-4'-ylamino)phenol against Plasmodium falciparum in vitro.

    Science.gov (United States)

    Scott, H V; Tan, W L; Barlin, G B

    1987-04-01

    Mono- and di-Mannich bases derived from 4-(7'-bromo-1',5'-naphthyridin-4'-ylamino)phenol and 4-(7'-trifluoromethylquinolin-4'-ylamino)phenol were assayed for antimalarial activity (using an in vitro radioisotopic technique) against two isolates of Plasmodium falciparum. Many from these two series of compounds had an IC50 value (concentration of compound causing 50% inhibition of 3H-hypoxanthine incorporation) comparable to or better than those of mefloquine and amodiaquine, for both a chloroquine-sensitive isolate (FCQ-27) and the chloroquine-resistant isolate (K1). At least one compound, 2,6-bis (piperidin-1''-ylmethyl)-4-(7'-trifluoromethylquinolin -4'-ylamino)phenol (TN112), showed significant superior activity to the three antimalarials chloroquine, mefloquine and amodiaquine against both isolates. (Statistically superior activity compared to these three antimalarials was found for TN112, except that against the K1 isolate its activity was just outside the range of significance relative to mefloquine.) Some of the 7-bromo-1,5-naphthyridine Mannich bases were appreciably less toxic in mice than amodiaquine.

  8. 金鸡纳碱及其衍生物在不对称Mannich反应中的应用%Application of Cinchona Alkaloid and their Derivatives in Asymmetric Mannich Reactions

    Institute of Scientific and Technical Information of China (English)

    潘昭喜; 何永光; 刘浩

    2012-01-01

    Catalytic enantioselective Mannich reactions provided one of the most versatile approaches for the synthesis of optically active chiral amines.Recently,several organocatalytic protocols were developed by using the parent cinchona alkaloids or their derivatives.It was a focus of considerable attention in the domestic and foreign research.The recent progress of asymmetric Mannich reactions catalyzed by cinchona alkaloids or their derivatives was generally reviewed.%不对称Mannich反应是一种应用最广泛的合成光学活性的手性氨基酸衍生物的方法,近几年基于金鸡纳碱及其衍生物的有机小分子催化的不对称Mannich反应成为国内外研究的热点,本文简要介绍了金鸡纳碱及其衍生物在不对称Mannich反应中的应用。

  9. The Verb Always Leaves IP in V2 Clauses

    DEFF Research Database (Denmark)

    Schwartz, Bonnie D.; Vikner, Sten

    2007-01-01

    The verb second (V2) phenomenon, as it is found in the Germanic languages, has been the focus of much attention within recent syntactic research. In most of the literature on V2, it is assumed that the verb in all V2 clauses has moved to a head position outside IP, e.g. Cº. In Schwartz & Vikner...... analysis in which the verb moves into an Xº which is the sister of IP may be compatible with what we say here. Various alternatives to this analysis have been explored in the literature, and here we will address two in particular: One alternative is that there is an asymmetry between subject...

  10. Signaling Elaboration: Combining French Gerund Clauses with Lexical Cohesion Cues

    Directory of Open Access Journals (Sweden)

    Marianne Vergez-Couret

    2012-07-01

    Full Text Available In this paper, we focus on the Elaboration relation and on its automatic identification in French, using the theoretical framework of Segmented Discourse Representation Theory (SDRT. One of the information sources identified by the SDRT framework to infer the Elaboration relation is based on the existence of a potential subsumption link between the eventualities at stake, depending on lexical semantics and world knowledge. We investigate this claim by combining a weak syntactic marker of the Elaboration relation, namely the gerund clause, with lexical cohesion cues. We aim at automatically identifying gerund clauses which are Elaborations by finding cohesive links between the host main clause and the gerund clause. This approach makes it possible to accurately detect few cases of intra-sentential Elaborations in our corpus, confirming the fact that lexical cohesion cues are relevant for this task.Dans cet article, nous nous focalisons sur la relation d’Élaboration en français, telle qu’elle est décrite dans le modèle théorique de la SDRT (Segmented Discourse Representation Theory, et sur son identification automatique. Selon la SDRT, une des sources d’information permettant d’inférer la relation d’Élaboration est basée sur l’existence d’un lien de subsomption entre les types des éventualités des segments à relier, indiquant que le type de la seconde éventualité est un sous-type de celui de la première dans la sémantique lexicale des éventualités ou grâce à des connaissances du monde. Nous proposons de contribuer à cette question en combinant un indice de la relation d’Élaboration, i. e. la construction syntaxique du gérondif, et des indices de cohésion lexicale. Notre objectif est d’identifier automatiquement des propositions gérondives qui sont des Élaborations en repérant des indices de cohésion lexicale entre la proposition principale et la proposition gérondive. Cette approche permet de d

  11. Integrating Conflict Driven Clause Learning to Local Search

    Directory of Open Access Journals (Sweden)

    Gilles Audenard

    2009-10-01

    Full Text Available This article introduces SatHyS (SAT HYbrid Solver, a novel hybrid approach for propositional satisfiability. It combines local search and conflict driven clause learning (CDCL scheme. Each time the local search part reaches a local minimum, the CDCL is launched. For SAT problems it behaves like a tabu list, whereas for UNSAT ones, the CDCL part tries to focus on minimum unsatisfiable sub-formula (MUS. Experimental results show good performances on many classes of SAT instances from the last SAT competitions.

  12. Moulding Interpersonal Relations through Conditional Clauses: Consensus-Building Strategies in Written Academic Discourse

    Science.gov (United States)

    Warchal, Krystyna

    2010-01-01

    This paper focuses on the interpersonal potential of the conditional clause as a rhetorical device for establishing a dialogue between the author and the reader of an academic text in search for shared understanding and consensus. It presents a corpus-based analysis of functions conditional clauses play in linguistics research articles in an…

  13. The Acquisition of Possessive HAVE-Clauses by Turkish and Moroccan Learners of Dutch.

    Science.gov (United States)

    van de Craats, Ineke; van Hout, Roeland; Corver, Norbert

    2002-01-01

    Describes how Turkish and Morrocan adults acquire Dutch possessive clauses in which the verb "have" expresses the possessive relationship. The acquisition process is explained within the framework of recent generative theory on which "have-clauses are assumed to be popular locative constructions. (Author/VWL)

  14. Acquisition of Zero Relative Clauses in English by Adult Turkish Learners of English

    Science.gov (United States)

    Ordem, Eser

    2017-01-01

    Studies on acquisition of relative clauses by first and second language learners have evoked considerable interest in recent decades. In line with such studies, in this present study we aim to show the possible effect of first language (Turkish) on second language (English) in zero relative clause constructions. English uses certain stranded…

  15. An Improved Separation of Regular Resolution from Pool Resolution and Clause Learning

    CERN Document Server

    Bonet, Maria Luisa

    2012-01-01

    We prove that the graph tautology principles of Alekhnovich, Johannsen, Pitassi and Urquhart have polynomial size pool resolution refutations that use only input lemmas as learned clauses and without degenerate resolution inferences. We also prove that these graph tautology principles can be refuted by polynomial size DPLL proofs with clause learning, even when restricted to greedy DPLL search.

  16. Processing of Relative Clauses is Made Easier by Frequency of Occurrence

    Science.gov (United States)

    Reali, Florencia; Christiansen, Morten H.

    2007-01-01

    We conducted a large-scale corpus analysis indicating that pronominal object relative clauses are significantly more frequent than pronominal subject relative clauses when the embedded pronoun is personal. This difference was reversed when impersonal pronouns constituted the embedded noun phrase. This pattern of distribution provides a suitable…

  17. Apple fruit copper amine oxidase isoforms: peroxisomal MdAO1 prefers diamines as substrates, whereas extracellular MdAO2 exclusively utilizes monoamines.

    Science.gov (United States)

    Zarei, Adel; Trobacher, Christopher P; Cooke, Alison R; Meyers, Ashley J; Hall, J Christopher; Shelp, Barry J

    2015-01-01

    4-Aminobutyrate (GABA) accumulates in apple fruit during controlled atmosphere storage. A potential source of GABA is the polyamine putrescine, which can be oxidized via copper-containing amine oxidase (CuAO), resulting in the production 4-aminobutanal/Δ(1)-pyrroline, with the consumption of O2 and release of H2O2 and ammonia. Five putative CuAO genes (MdAO genes) were cloned from apple (Malus domestica Borkh. cv. Empire) fruit, and the deduced amino acid sequences found to contain the active sites typically conserved in CuAOs. Genes encoding two of these enzymes, MdAO1 and MdAO2, were highly expressed in apple fruit and selected for further analysis. Amino acid sequence analysis predicted the presence of a C-terminal peroxisomal targeting signal 1 tripeptide in MdAO1 and an N-terminal signal peptide and N-glycosylation site in MdAO2. Transient expression of green fluorescent fusion proteins in Arabidopsis protoplasts or onion epidermal cells revealed a peroxisomal localization for MdAO1 and an extracellular localization for MdAO2. The enzymatic activities of purified recombinant MdAO1 and MdAO2 were measured continuously as H2O2 production using a coupled reaction. MdAO1 did not use monoamines or polyamines and displayed high catalytic efficiency for 1,3-diaminopropane, putrescine and cadaverine, whereas MdAO2 exclusively utilized aliphatic and aromatic monoamines, including 2-phenylethylamine and tyramine. Together, these results indicate that MdAO1 may contribute to GABA production via putrescine oxidation in the peroxisome of apple fruit under controlled atmosphere conditions. MdAO2 seems to be involved in deamination of 2-phenylethylamine, which is a step in the biosynthesis of 2-phenylethanol, a contributor to fruit flavor and flower fragrance.

  18. MD 382: Beam Transfer Function and diffusion mechanisms

    CERN Document Server

    Tambasco, Claudia; Buffat, Xavier; Crouch, Matthew; Pieloni, Tatiana; Boccardi, Andrea; Fuchsberger, Kajetan; Gasior, Marek; Kotzian, Gerd; Lefevre, Thibaut; Pojer, Mirko; Salvachua Ferrando, Belen Maria; Solfaroli Camillocci, Matteo; Giachino, Rossano; CERN. Geneva. ATS Department

    2016-01-01

    The Beam Transfer Function (BTF) measurements have been previously tested in the LHC during MD block 1 and 2. Different machine configurations (i.e. energy, beam intensity, emittance etc...) have been tested to determine a safe set-up (excitation amplitude) of the system to be completely transparent to the beam (no emittance blow-up neither losses). The aim of this experiment in MD block 3 was to characterize the Stability Diagram (SD) in the presence of diffusion mechanisms induced by excited resonances due to beam-beam long range and Landau octupole interplay. During the experiment, BTF measurements have been acquired at flat top for different settings of Landau octupole current, different chromaticity values and transverse feedback gains. In this note the description of the experiment is presented together with some preliminary results.

  19. MD210 Note: Creation of Hollow Bunches in the PSB

    CERN Document Server

    Oeftiger, Adrian; Findlay, Alan James; Hancock, Steven; Rumolo, Giovanni; CERN. Geneva. ATS Department

    2016-01-01

    MD210 aims for the creation of longitudinally hollow bunches in the CERN PS Booster. The first three sessions have been carried out using the radial loop feedback system in order to drive the beam on a dipolar parametric resonance (instead of the phase loop). It has been found that the damping by the phase loop inhibits the excitation of the resonance to a major extent. The hollow distributions generated under these circumstances fail to reach a satisfying bunching factor. Nonetheless, proving the principally successful application of this technique to the PS Booster promises good results once the phase loop system supports trim functions. The approach, actions and detailed results of the first three MD sessions are presented in this paper.

  20. A Fast Attack Algorithm on the MD5 Hash Function

    Institute of Scientific and Technical Information of China (English)

    WANG Zhang-yi; ZHANG Huan-guo; QIN Zhong-ping; MENG Qing-shu

    2006-01-01

    The sufficient conditions for keeping desired differential path of MD5 was discussed. By analyzing the expanding of subtraction difference, differential characters of Boolean functions, and the differential characters of shift rotation, the sufficient conditions for keeping desired differential path could be obtained. From the differential characters of shift rotation, the lacked sufficient conditions were found. Then an algorithm that reduces the number of trials for finding collisions were presented. By restricting search space, search operation can be reduced tc 234 for the first block and 230 for the second block. The whole attack on the MD5 can be accomplished within 2C hours using a PC with 1.6 G CPU.

  1. Understanding of subordinate clauses in the language of dysphasic children

    Directory of Open Access Journals (Sweden)

    Lazarević Emilija

    2007-01-01

    Full Text Available This paper presents the results of the research of peculiarities of syntactic development, as an element of language structure on the grammatical level of children suffering from developmental dysphasia, after the completed speech pathology treatment of many years. Syntactic level at younger school age was studied by assessing language competence in the accomplishment of communicative sentence with subordinate clause. The research was performed on the samples of children at school age in regular primary schools in Belgrade. The sample comprised 160 respondents who were divided in two groups: target and comparative. The target group consisted of 60 respondents (children suffering from developmental dysphasia after the completed speech pathology treatment of many years, and the comparative group consisted of 100 respondents from regular primary school "Gavrilo Princip" in Zemun. Research results show that grammatical development of children suffering from developmental dysphasia takes place at a considerably slower rate and entails substantially more difficulties in accomplishing predication in subordinate clauses. This paper discusses the consequences which the difficulties in grammatical development can have on school achievement.

  2. Visual salience modulates structure choice in relative clause production.

    Science.gov (United States)

    Montag, Jessica L; MacDonald, Maryellen C

    2014-06-01

    The role of visual salience on utterance form was investigated in a picture description study. Participants heard spoken questions about animate or inanimate entities in a picture and produced a relative clause in response. Visual properties of the scenes affected production choices such that less salient inanimate entities tended to yield longer initiation latencies and to be described with passive relative clauses more than visually salient inanimates. We suggest that the participants' question-answering task can change as a function of visual salience of entities in the picture. Less salient entities require a longer visual search of the scene, which causes the speaker to notice or attend more to the non-target competitors in the picture. As a result, it becomes more important in answering the question for the speaker to contrast the target item with a salient competitor. This effect is different from other effects of visual salience, which tend to find that more salient entities take more prominent grammatical roles in the sentence. We interpret this discrepancy as evidence that visual salience does not have a single effect on sentence production, but rather its effect is modulated by task and linguistic context.

  3. WH-extractions and relative clauses in Brazilian Portuguese

    Directory of Open Access Journals (Sweden)

    NEGRÃO Esmeralda Vailati

    2000-01-01

    Full Text Available This paper aims to describe and explain WH-extraction patterns out of island contexts in Brazilian Portuguese (BP, by means of the principles established by Generative Theory. I claim that BP uses a strategy for the extraction of subjects which involves a special case of Agreement. Extractions out of relative islands are possible when the extracted WH-phrase ends up in the specifier position of the higher CP and from there it behaves as the subject of the predication. The subject-predicate relationship established under agreement makes Comp a proper governor for traces in subject position under its scope. The analysis proposed makes a distinction between two processes of relative clause formation. One in which que is an operator that transforms sentences into predicates and sits in the Comp position of a CP whose specifier can be occupied by a QP functioning as the subject of the predication. The other, in which que is a WH-word, traditionally treated as a pronoun, occupying the specifier position of a QP and introducing relative clauses as we know them.

  4. Analytical applications of MD-FIA-optical detection systems

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A brief introduction of recent research works in our laboratory concerning microdialysis(MD) based on optical detection combined with FIA is made in this mini-review. A biosensor system has been designed and realized the real time in vivo monitoring of some important clinic substances such as calcium, uric acid. The system has also been used to study the in vitro binding of drug-protein.

  5. MD 349: Impedance Localization with AC-dipole

    CERN Document Server

    Biancacci, Nicolo; Metral, Elias; Salvant, Benoit; Papotti, Giulia; Persson, Tobias Hakan Bjorn; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the distribution of the transverse impedance of the LHC by observing the phase advance variation with intensity between the machine BPMs. Four injected bunches with different intensities are excited with an AC dipole and the turn by turn data is acquired from the BPM system. Through post-processing analysis the phase variation along the machine is depicted and, from this information, first conclusions of the impedance distribution can be drawn.

  6. Summary of LHC MD:377: Schottky pick-up

    CERN Document Server

    Betz, Michael; Lefevre, Thibaut; CERN. Geneva. ATS Department

    2015-01-01

    The main objective of this MD was to record Schottky spectra under well known machine conditions. In summary, 7 set-points for the chromaticity and 8 for the emittance have been established and Schottky spectra have been recorded for each setting. The data will be used to benchmark and develop different fitting algorithms. This note presents the initial attempt of curve-fitting and discusses its shortcomings.

  7. Application of MD simulations to predict membrane properties of MOFs

    OpenAIRE

    Elda Adatoz; Seda Keskin

    2015-01-01

    Research Article Application of MD Simulations to Predict Membrane Properties of MOFs Elda Adatoz and Seda Keskin Chemical and Biological Engineering, Koc University, Rumelifeneri Yolu, Sariyer, 34450 Istanbul, Turkey Correspondence should be addressed to Seda Keskin; Received 22 May 2015; Accepted 13 July 2015 Academic Editor: Yanlin Song Copyright © 2015 E. Adatoz and S. Keskin. This is an open access article distributed under the Creative Commons A...

  8. MD 346: Summary of single bunch instability threshold measurements

    CERN Document Server

    Carver, Lee Robert; Metral, Elias; Salvant, Benoit; Levens, Tom; Buffat, Xavier; Pieloni, Tatiana; Tambasco, Claudia; Trad, Georges; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the octupole current threshold to reach single-bunch stability in the LHC at flat top. Two bunches with dierent emittances are injected in the LHC in both B1 and B2 and the current in the Landau octupoles was progressively decreased until an instability developed. The measurements provide insight into the LHC impedance model by comparing them with the stabilizing octupole current predicted from DELPHI.

  9. Implementation of MD5 Fast Decryption Algorithm Based on Graphic Processing Unit%基于GPU的MD5高速解密算法的实现

    Institute of Scientific and Technical Information of China (English)

    乐德广; 常晋义; 刘祥南; 郭东辉

    2010-01-01

    MD5快速碰撞算法由于不支持逆向过程而无法在MD5密码攻击中得到实际应用.针对上述问题,通过分析基于图形处理单元(GPU)的MD5密码并行攻击算法原理,设计基于GPU的MD5高速解密算法,在此基础上实现一个MD5高速密码攻击系统.测试结果证明,该算法能有效加快MD5密码破解速度.

  10. Application of MD5 Algorithm in Database System%MD5算法在数据库系统中的应用

    Institute of Scientific and Technical Information of China (English)

    罗金涛

    2013-01-01

    数据加密是保护数据安全的重要手段,MD5是目前信息安全领域中使用比较广泛的加密算法,对MD5算法的原理进行了分析,并将MD5算法应用在数据库的登录验证过程中.

  11. Immunization against mucosal disease--bovine viral Diarrhea (MD-BVD) in calves applying lapinized vaccine against swine fever and a modified live virus of MD-BVD.

    Science.gov (United States)

    Haralambiev, H; Tsvetkov, P; Nikolov, A; Gaytandgieva, R

    1975-01-01

    Calves vaccinated with the modified strain C24V react by creating neutralizing antibodies in high titres and are resistent to infection while non-immunized calves manifest the clinical symptoms of MD-BVD. Calves, vaccinated with the lapinized strain "K" of the SF virus react by creating neutralizing antibodies in low titres against the vius of MD-BVD and manifest no apparent clinical symptoms after challenge with the virulent strain MD-BVD.

  12. 76 FR 71369 - Robert G. Crummie, M.D.; Decision and Order

    Science.gov (United States)

    2011-11-17

    ... intend administrative agencies to perform meaningless tasks. See Layfe Robert Anthony, M.D., 67 FR 35582... authority under the laws of the state in which he does business. See Scott Sandarg, D.M.D., 74 FR 17528 (DEA 2009); David W. Wang, M.D., 72 FR 54297 (DEA 2007); Sheran Arden Yeates, M.D., 71 FR 39130 (DEA...

  13. The Application Research of MD5 Encryption Algorithm in DCT Digital Watermarking

    Science.gov (United States)

    Xijin, Wang; Linxiu, Fan

    This article did the preliminary study of the application of algorithm for MD5 in the digital watermark. It proposed that copyright information will be encrypted using an algorithm MD5, and made rules for the second value image watermarks, through DCT algorithm that embeds an image by the carrier. The extraction algorithms can pick up the watermark and restore MD5 code.

  14. 76 FR 48884 - Stacey J. Webb, M.D.; Denial of Application

    Science.gov (United States)

    2011-08-09

    .... DEA, 2008 WL 4899525 (6th Cir. 2008). ``Moreover, because `past performance is the best predictor of.... Stodola, M.D., 74 FR 20727 (2009); Dale L. Taylor, M.D., 72 FR 30855 (2007); Andre DeSonia, M.D., 72...

  15. 76 FR 20034 - Calvin Ramsey, M.D.; Revocation of Registration

    Science.gov (United States)

    2011-04-11

    ... Enforcement Administration Calvin Ramsey, M.D.; Revocation of Registration On December 18, 2009, the Deputy... Show Cause to Calvin Ramsey, M.D. (Respondent), of Millington, Tennessee. The Show Cause Order proposed..., I order that DEA Certificate of Registration, AR7086689, issued to Calvin Ramsey, M.D., be, and...

  16. Preparation and Properties of A Novel Modified Mannich Amine as Waterborne Epoxy Curing Agent%改性曼尼希胺水性环氧固化剂的制备及性能

    Institute of Scientific and Technical Information of China (English)

    李楚新; 段颖; 丁嘉欣; 夏新年

    2012-01-01

    A novel Modified Mannich Amine ( MAI ) was synthesized by amine exchange reaction using polyether amine (D -230) and DMP -30 as raw materials. A liquid epoxy resin (EP) and a homemade mono -functional epoxy polymer (PEG - EP) were used as chain extender for MAl's chain extension modifica tion, which was then terminated with phenyl glycidyl ether(PGE) to get Modified Mannich Amine(MA3). Finally, the Mannich amine waterborne epoxy curing agents ( CAs) were produced by phase - inversion e- mulsification method and used for waterborne epoxy resin. The influences of the PEG - EP amount, the feed ing ratio of MA1/EP and MAI/PEG on the stability of the dispersion were studied. The chemical structures and properties of the cured films were studied by physical chemistry method. The cured films of an optimiza tion system showed a hardness 229 s, flexibility 1 mm, adhesion 0 grade, pot ?life 5 h, and excellent water resistance.%以聚醚胺(D - 230)和DMP - 30为原料,利用胺交换反应制得一种新型的改性曼尼希胺(MAI).然后以自制的端官能环氧聚合物( PEG - EP)与低相对分子质量液体环氧树脂(EP)为扩链剂对MAI进行扩链改性,并用苯基缩水甘油醚(PGE)封端,最后采用相反转法制得了一种新型的改性曼尼希水性环氧固化剂.讨论了PEG - EP的添加量、MAI与EP的加料比及封端剂的添加量对水性固化剂体系稳定性的影响.并采用物理化学方法对反应程度及涂膜的性能进能了表征分析.优化体系固化涂膜硬度229s,柔韧性1mm,附着力0级,适用期5h,耐水性优异.

  17. MD5算法在用户口令认证中的应用%The Application of MD5 Algorithm in The User Password Authentication

    Institute of Scientific and Technical Information of China (English)

    刘洪民; 印帮辉

    2014-01-01

    MD5算法是目前比较安全且易用的加密算法,其在密码领域有着举足轻重的地位.本文通过介绍MD5算法的特点及加密原理,分析了MD5算法在用户口令认证中的安全隐患,给出了用户口令认证应用中如何提高MD5算法安全性的措施和方法.

  18. Application of MD5 Encryption Algorithm Based on C# Technology%基于C#技术的MD5加密算法的应用

    Institute of Scientific and Technical Information of China (English)

    王倩丽

    2010-01-01

    在对Message-Digest Algorithm 5进行简要描述的同时,对MD5算法的原理作深入分析.运用MD5算法,采用目前流行的C#语言进行了具体研究,设计了MD5加密演示系统,经过测试该系统可以准确实现数据的MD5加密.

  19. SECURITY ANALYSIS ON MD5 AND ITS APPLICATION%MD5安全性分析及其应用

    Institute of Scientific and Technical Information of China (English)

    谭剑鸣; 徐建华; 汪崇华

    2002-01-01

    本文详细论述了MD5报文分解函数对文件签名的工作原理,剖析了MD5的安全性,针对具体的应用提出了使用MD5与RSA结合来解决数字签名的完整方案.文章的最后对MD5在PGP数字签名中的具体应用进行了分析讨论.

  20. Design and Implementation of MD5 with Salt%一种带随机数MD5算法的设计与实现

    Institute of Scientific and Technical Information of China (English)

    张丽香

    2013-01-01

    随着网络的迅速普及,信息加密技术的发展对保障网络安全有着重大的作用与意义.MD5是HASH算法,常用来对重要数据的进行存储,本文对MD5算法进行了简要描述,介绍了MD5的破解方式,并对带随机数MD5算法进行了描述,采用PHP对算法的使用进行实现.

  1. Relative Clauses in Spectroscopic Articles in the "Physical Review, "Beginnings and 1980: Some Changes in Patterns of Modification and a Connection to a Possible Shift in Style.

    Science.gov (United States)

    Vande Kopple, William J.

    1998-01-01

    Examines the number of relative clauses and percentages of subordinate clauses in two sets of research reports from "Physical Review." Finds a slight decrease in percentages of relative clauses from the first set (1893-1901) to the second (1980). Finds striking differences in patterns of what relative clauses modify. Suggests a stylistic…

  2. THE ROLE OF THE GRAMMAR ON PORTUGUESE TEXTBOOKS: A LOOK ON TEACHING OF RELATIVE CLAUSE

    Directory of Open Access Journals (Sweden)

    Aliana Lopes CÂMARA

    2014-12-01

    Full Text Available This paper studies how the textbooks of Portuguese Language of Secondary School, approved by the Programa Nacional do Livro Didático-2014, approach the teaching of grammar, in particular as regards the treatment of the relative subordinate clause. For this, first we start with the comparison between the proposals manuals for teaching grammar and what was accomplished in the student book. Furthermore, we propose here an interface between the results of the analysis of textbooks and functional description of the relative clause. In other words, we try to verify as some descriptive aspects can be used in the teaching of relative clause, with the aim of developing reading and writing skills. In order to do that, we take as theoretical framework the different conceptions of grammar proposed in Travaglia (2009, 2011 and Functional Discourse Grammar (HENGEVELD; MACKENZIE, 2008. This research points to the need to emphasize the cohesive role established by the relative pronoun that introduces the relative clause, to understand the non-restrictive relative clause from its argumentative function and to review the distinction between subtypes of adjective clause from the criteria of omission of the subordinate clause.

  3. Assessing students' epistemic logic using clause topics during problem comparison

    Science.gov (United States)

    Mateycik, Fran; Sheaffer, Kendra

    2013-01-01

    Physics courses ideally facilitate both students understanding of fundamental physical principles, as well as strengthen students' problem solving repertoire. In this study we look at how students divide and/or aggregate various elements of problem statements and how useful distinct principles and concepts, formulae, and general problem contexts are for pairing problems assigned in the same week. Students in an algebra-based physics course were asked to choose two problems from each of their homework assignments which they found to be most similar. The two problems selected were then explicitly compared and contrasted in writing. The written statements were then divided by clause topics and further categorized into levels of epistemic reasoning. This paper presents the qualitative analysis used and provides observed trends that appear in students' homework responses.

  4. Pharmacist conscience clauses and access to oral contraceptives.

    Science.gov (United States)

    Flynn, D P

    2008-07-01

    The introduction of conscience clauses after the 1973 US Supreme Court decision in Roe v. Wade allowed physicians and nurses to opt out of medical procedures, particularly abortions, to which they were morally opposed. In recent years pharmacists have requested the same consideration with regard to dispensing some medicines. This paper examines the pharmacists' role and their professional and moral obligations to patients in the light of recent refusals by pharmacists to dispense oral contraceptives. A review of John Rawls's concepts of the "original position" and the "veil of ignorance", along with consideration of the concept of compartmentalisation, are used to assess pharmacists' requests and the moral and legal rights of patients to have their prescriptive needs met.

  5. 改进MD5码增强网站密码安全性

    Institute of Scientific and Technical Information of China (English)

    张越; 陈跃; 刘林飞

    2009-01-01

    目的探讨改进MD5码,增强网络安全性.方法采用对用户密码进行加长、加强的二次加密,并对MD5码的算法进行修改,再使用MD5二次加密或多次加密.结果通过改进MD5码,用户密码安全性明显增强.结论改进MD5码,可以提高网站安全性.

  6. Nano-scratch study of molecular deposition (MD) films on silicon wafer using nanoindentation~1

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Experiment of the molecular deposition (MD) films with and without alkyl terminal de-posited on the silicon wafer were conducted by using nanoindentation. It was found that MD filmsand alkyl terminated MD films exhibit higher critical load (scratch resistance or adhesive strength)and lower coefficient of friction compared with the silicon substrate. Critical load (scratch resis-tance) increases with the number of layers, and coefficients of friction of those MD film with alkylterminal are still best for the same layer of MD film.

  7. Subject of Subordinate Clause as Object with Verbs of Perception, Thought, and Communication in Old Russian

    Directory of Open Access Journals (Sweden)

    Anna A. Pichkhadze

    2012-08-01

    Full Text Available This paper describes the Old Russian construction involving verbs of perception, thought, and communication. In this construction, a single semantic argument corresponds to two syntactic constituents: a direct object and a finite subordinate clause, the subject of which is coreferential with the direct object of the main clause. The Old Russian construction is seen as an instantiation of a cross-linguistic option in the argument structure of these verbs (above all, of the perception verbs, that is, to take the subject of the subordinate clause as the direct object.

  8. StandsSIM-MD: a Management Driven forest SIMulator

    Energy Technology Data Exchange (ETDEWEB)

    Barreiro, S.; Rua, J.; Tomé, M.

    2016-07-01

    Aim of the study. The existing stand level forest simulators available in Portugal were not developed with the aim of including up-to-date model versions and were limited in terms of accounting for forest management. The simulators’ platform, sIMfLOR was recently created to implement different growth models with a common philosophy. The objective was developing one easily-updatable, user-friendly, forest management and climate change sensitive simulator capable of projecting growth for the main tree species in Portugal. Area of the study: Portugal. Material and methods: The new simulator was programmed in a modular form consisting of several modules. The growth module integrates different forest growth and yield models (empirical and process-based) for the main wood production tree species in Portugal (eucalypt, umbrella and maritime pines); whereas the management module drives the growth projections along the planning horizon according to a range of forest management approaches and climate (at present only available for eucalypt). Main results: The main result is the StandsSIM-MD Management Driven simulator that overcomes the limitations of the existing stand level simulators. It is a step forward when compared to the models currently available in the sIMfLOR platform covering more tree species, stand structures and stand compositions. It is focused on end-users and it is based on similar concepts regarding the generation of required inputs and generated outputs. Research highlights: Forest Management Driven simulations approach. Multiple Prescriptions-Per-Stand functionality. StandsSIM-MD can be used to support landowners decisions on stand forest management. StandsSIM-MD simulations at regional level can be combined with optimization routines. (Author)

  9. A Secure Hash Function MD-192 With Modified Message Expansion

    CERN Document Server

    Tiwari, Harshvardhan

    2010-01-01

    Cryptographic hash functions play a central role in cryptography. Hash functions were introduced in cryptology to provide message integrity and authentication. MD5, SHA1 and RIPEMD are among the most commonly used message digest algorithm. Recently proposed attacks on well known and widely used hash functions motivate a design of new stronger hash function. In this paper a new approach is presented that produces 192 bit message digest and uses a modified message expansion mechanism which generates more bit difference in each working variable to make the algorithm more secure. This hash function is collision resistant and assures a good compression and preimage resistance.

  10. 含1,3,4-噻二唑基团的Mannich碱的合成与抑菌活性的研究%Synthesis and Antifungal Activitiy of Mannich Base Containing 1,3,4-thiadiazole

    Institute of Scientific and Technical Information of China (English)

    郑广进; 张翠忠; 曾振芳

    2016-01-01

    以5-烷基-2-氨基-1,3,4-噻二唑、芳醛及β-萘酚为原料,在微波辐射下经Mannich反应合成了10种未见文献报道的含1,3,4-噻二唑基团的Mannich碱,其结构经IR和1 H NMR确证。采用菌丝生长速率法测试了目标化合物的抑菌活性,初步抑菌活性测试结果表明,在50 mg/L的浓度下,所有目标化合物对5种供试植物病原菌均有不同程度的抑菌活性,其中化合物b对番茄细菌性斑点病菌的抑制率达80%以上。%Ten novel mannich bases containing 1 ,3 ,4-thiadiazole were synthesized using 5-alkyl-2-amine-1 ,3 ,4-thiadiazol, aromatic aldehyde and β-naphthol as raw material via mannich reaction under microwave irradiation. The structures of all compounds were confirmed by IR and 1 H NMR. The antifungal activitiys of the target compounds were tested by mycelium growth rate method, preliminary bioassay showed that all the synthesized compounds had different inhibition on five tested plant pathogenic fungi at the concentration of 50 mg/L, among them, the inhibition rate of b against Pseudomonas syingae pv. tomato was above 80%.

  11. First-Principle Molecular Dynamics Study of Selected Schiff and Mannich Bases:  Application of Two-Dimensional Potential of Mean Force to Systems with Strong Intramolecular Hydrogen Bonds.

    Science.gov (United States)

    Jezierska, Aneta; Panek, Jarosław J

    2008-03-01

    Car-Parrinello Molecular Dynamics simulations were performed for selected anharmonic systems, i.e., Schiff and Mannich base-type compounds, to investigate the vibrational properties associated with O-H stretching. All calculations were performed in the gas phase to compare them with available experimental data. First the vibrational properties of the two compounds were analyzed on the basis of well-established approaches:  Fourier transformation of the autocorrelation function of both the atomic velocities and dipole moments. Then path integral molecular dynamics simulations were performed to demonstrate the influence of quantum effects on the proton's position in the hydrogen bridge. In addition, quantum effects were incorporated a posteriori into calculations of O-H stretching envelopes for the Schiff and Mannich bases. Proton potential snapshots were extracted from the ab initio molecular dynamics trajectory. Vibrational Schrödinger equations (one- and two-dimensional) were solved numerically for the snapshots, and the O-H stretching envelopes were calculated as a superposition of the 0→1 transitions. Subsequently, one- and two-dimensional potentials of mean force (1D and 2D pmf) were calculated for the proton stretching mode from the proton vibrational eigenfunctions and eigenvalues incorporating statistical sampling and nuclear quantum effects. The results show that the applied methodologies are in good agreement with experimental infrared spectra. Additionally, it is demonstrated that the 2D pmf method could be applied in systems with strong anharmonicity to describe the properties of the O-H stretching mode more accurately. Future applications of the 2D pmf technique include, in principle, large biomolecular systems treated within the QM/MM framework.

  12. 散列算法MD5和SHA-1的比较%Comparison between MD5 and SHA-1

    Institute of Scientific and Technical Information of China (English)

    王泽; 曹莉莎

    2016-01-01

    MD5 and SHA-1 are the two known Hash Algorithm which are widely applied in information security, they are both developed from MD4.This paper introduces their algorithm logic in detail, compares them though simulation experiment ,soft-ware testing, etc. Finally, it draw a conclusion:The SHA-1 algorithm is more secure than the MD5 algorithm, but in the same hardware, SHA-1 is slower than MD5.%MD5和SHA-1是两个已知的广泛应用于信息安全的散列算法,均由MD4发展而来。详细介绍了它们的算法逻辑,并通过模拟实验、软件测试等方式对其在各个方面进行比较,最终得出结论:SHA-1算法比MD5算法的安全性更高,但在同一硬件上,SHA-1比MD5运行的要慢。

  13. MD5加密算法的研究及应用%Research and application of MD5 encryption algorithm

    Institute of Scientific and Technical Information of China (English)

    魏晓玲

    2010-01-01

    针对当前网站建设和系统开发中用户信息等重要数据的安全问题,提出了一种MD5加密算法,可以对用户密码进行加密.MD5加密算法是一种比较常用的单向加密算法,通过对该算法的深入研究,介绍了MD5算法的特性、算法原理及其算法流程,并给出MD5算法在一个具体系统中的实际应用,得出MD5算法是一种非常安全和易用的加密算法.

  14. Methanol adsorption studies of electrified ACF by MD simulations

    Institute of Scientific and Technical Information of China (English)

    LIANG Shiqiang; XU Jingzhong

    2004-01-01

    In order to clarify whether static electricity can impose a control on physical adsorption of polar adsorbates, MD simulations were carried out to study the adsorption/desorption behavior of methanol in the nanopores of electrified activated carbon fiber (ACF). Some special phenomena were observed from the MD simulations for methanol adsorption in a mesopore of electrified ACF. For example it takes a shorter time for the adsorbates to reach the adsorption sites on the mesopore wall, the liquid-like methanol is highly condensed, the methanol molecules have a unique distribution of space orientation, and the total energy of equilibrium state dropped a lot. These phenomena indicate the static electricity reinforced the interaction between the polar methanol and the electrified ACF, so that the intensity, stability and regularity of adsorption were increased, and thus we predict that the adsorption capacity will be increased and the adsorption process will be accelerated. When adsorption equilibrium was reached at room temperature, eliminated the electric charges and heated the system, the desorption tendency was evidently observed from our simulations at 60℃ or so.

  15. MD1878: Operation with primary collimators at tighter settings

    CERN Document Server

    Mirarchi, Daniele; Biancacci, Nicolo; Bruce, Roderik; Buffat, Xavier; Carver, Lee Robert; Fiascaris, Maria; Mereghetti, Alessio; Redaelli, Stefano; Rossi, Roberto; Salvachua Ferrando, Belen Maria; Soderen, Martin; Trad, Georges

    2017-01-01

    Primary (TCP) collimators of the betatron cleaning insertion determine the betatron cut of the LHC beam. During the 2016 they were set at 5.5 nominal beam sigmas at 6.5 TeV (i.e. by using a normalized emittance " = 3:5 m is used). Reducing their settings is a possible way to push the at the LHC, which depends on the collimation hierarchy. This study aims at understanding possible limitations of operating the LHC with tighter settings of the primary collimators. This is a crucial input to the choice of operational conguration in terms of at the LHC as well as at the HL-LHC. This study follows a successful MD done in block 3 to understand limitations from TCP impedance [1]. The outcome of this MD can also have an impact for the design of the FCC collimation system, which is currently based on the present TCP gaps. Studies of beam stability as a function of octupole current, transverse feedback gain (ADT) and transverse separation at the IPs were also carried out.

  16. MD modeling of defects in Fe and their interactions

    Science.gov (United States)

    Marian, Jaime; Wirth, Brian D.; Schäublin, Robin; Odette, G. R.; Perlado, J. Manuel

    2003-12-01

    Ferritic/martensitic steels considered as candidate first-wall materials for fusion reactors experience significant radiation hardening at temperatures below ˜400 °C. A number of experimental studies in ferritic alloys, performed at higher temperatures, have shown the existence of large interstitial loops with Burgers vector {1}/{2} and in the bulk, which may provide a significant contribution to the hardening caused during irradiation at lower temperatures. Hardening arises from a high number density of loops, voids and small precipitates, which pin system dislocations, impeding their free glide. In this work, we review the nature of the different interstitial dislocation loops observed in α-Fe and ferritic materials, assess the effect of substitutional impurities on migrating {1}/{2} clusters, and apply atomistic modeling to investigate the mechanisms of formation and growth of loops from smaller cascade-produced {1}/{2} clusters. The proposed mechanism reconciles experimental observations with continuum elasticity theory and recent MD modeling of defect production in displacement cascades. In addition, the interaction of screw dislocations, known to control the low-temperature plastic response of b.c.c. materials to external stress, with dislocation loops is investigated with MD, where the main physical mechanisms are identified, cutting angles estimated and a first-order estimation of the induced hardening is provided.

  17. MD1878: Operation with primary collimators at tighter settings

    CERN Document Server

    Mirarchi, Daniele; Biancacci, Nicolo; Bruce, Roderik; Buffat, Xavier; Carver, Lee Robert; Fiascaris, Maria; Mereghetti, Alessio; Redaelli, Stefano; Rossi, Roberto; Salvachua Ferrando, Belen Maria; Soderen, Martin; Trad, Georges; CERN. Geneva. ATS Department

    2017-01-01

    Primary (TCP) collimators of the betatron cleaning insertion determine the betatron cut of the LHC beam. During the 2016 they were set at 5.5 nominal beam sigmas at 6.5 TeV (i.e. by using a normalized emittance ε* = 3:5 μm is used). Reducing their settings is a possible way to push the ß* at the LHC, which depends on the collimation hierarchy. This study aims at understanding possible limitations of operating the LHC with tighter settings of the primary collimators. This is a crucial input to the choice of operational configuration in terms of ß* at the LHC as well as at the HL-LHC. This study follows a successful MD done in block 3 to understand limitations from TCP impedance [1]. The outcome of this MD can also have an impact for the design of the FCC collimation system, which is currently based on the present TCP gaps. Studies of beam stability as a function of octupole current, transverse feedback gain (ADT) and transverse separation at the IPs were also carried out.

  18. Parallel functional category deficits in clauses and nominal phrases: The case of English agrammatism.

    Science.gov (United States)

    Wang, Honglei; Yoshida, Masaya; Thompson, Cynthia K

    2014-01-01

    Individuals with agrammatic aphasia exhibit restricted patterns of impairment of functional morphemes, however, syntactic characterization of the impairment is controversial. Previous studies have focused on functional morphology in clauses only. This study extends the empirical domain by testing functional morphemes in English nominal phrases in aphasia and comparing patients' impairment to their impairment of functional morphemes in English clauses. In the linguistics literature, it is assumed that clauses and nominal phrases are structurally parallel but exhibit inflectional differences. The results of the present study indicated that aphasic speakers evinced similar impairment patterns in clauses and nominal phrases. These findings are consistent with the Distributed Morphology Hypothesis (DMH), suggesting that the source of functional morphology deficits among agrammatics relates to difficulty implementing rules that convert inflectional features into morphemes. Our findings, however, are inconsistent with the Tree Pruning Hypothesis (TPH), which suggests that patients have difficulty building complex hierarchical structures.

  19. L2 Acquisition of Complement Clauses by Persian Learners of English

    Directory of Open Access Journals (Sweden)

    Masoud Khalili Sabet

    2015-01-01

    Full Text Available This research concentrates on the acquisition of complement clauses within Universal Grammar framework which theoretically plays the strongest linguistic role in second language acquisition research in recent years. This study aims to investigate how Persian learners of English at three levels of proficiency acquire complement clauses.  In fact, this study reports the results of the learners’ responses to GJT and specifically investigates the six linguistic variables associated with complement Clauses: using complement in finite/ non-finite clauses, small-clauses, exceptional-clauses, that-trace effect in clauses and subcategorization of two verbs (i. e. want and let.  The responses were given by 50 Persian learners of English divided into three proficiency levels: Elementary, Intermediate and Advanced. The statistical analyses of the data revealed that, by increasing the participants’ level of proficiency their judgment of grammatical and ungrammatical items was improved whereas the differences between groups were also significant. The results can indicate that the development of their complement acquisition is generally systematic.  In addition, by carrying out syntactic analyses of the sentences that the participants produced, we conclude that, as UG predicted, Persian learners do not use any wild grammar at any level of their L2 acquisition.  The above findings are generally in harmony with the view that L2 learners somehow attain the unconscious knowledge that goes beyond what they receive as L2 input.  Finally, our findings may have implications for language teaching by deepening our understanding of the nature of L2 acquisition. Keywords: Second Language Acquisition, Complements, Clauses, Developmental stages, Systematicity, Universal Grammar, Fundamental Different Hypothesis (FDH

  20. [Professor Frantisek Por MD and Professor Robert Klopstock MD, students at Budapest and Prague Faculties of Medicine].

    Science.gov (United States)

    Mydlík, M; Derzsiová, K

    2010-11-01

    Professor Frantisek Por MD and Professor Robert Klopstock MD were contemporaries, both born in 1899, one in Zvolen, the other in Dombovar, at the time of Austro-Hungarian Monarchy. Prof. Por attended the Faculty of Medicine in Budapest from 1918 to 1920, and Prof. Klopstock studied at the same place between 1917 and 1919. From 1920 until graduation on 6th February 1926, Prof. Por continued his studies at the German Faculty of Medicine, Charles University in Prague. Prof. Klopstock had to interrupt his studies in Budapest due to pulmonary tuberculosis; he received treatment at Tatranske Matliare where he befriended Franz Kafka. Later, upon Kafka's encouragement, he changed institutions and continued his studies at the German Faculty of Medicine, Charles University in Prague, where he graduated the first great go. It is very likely that, during their studies in Budapest and Prague, both professors met repeatedly, even though their life paths later separated. Following his graduation, Prof. Por practiced as an internist in Prague, later in Slovakia, and from 1945 in Kosice. In 1961, he was awarded the title of university professor of internal medicine at the Faculty of Medicine, Pavol Jozef Safarik University in Kosice, where he practiced until his death in 1980. Prof. Klopstock continued his studies in Kiel and Berlin. After his graduation in 1933, he practiced in Berlin as a surgeon and in 1938 left for USA. In 1962, he was awarded the title of university professor of pulmonary surgery in NewYork, where he died in 1972.

  1. The improvement of cryptography MD5 algorithm%密码学中信息摘要算法MD5的改进

    Institute of Scientific and Technical Information of China (English)

    林平

    2011-01-01

    MD5算法的基础上,针对MD5算法密文是一个32位16进制字符来表示值的特征,提出MD5改进算法,首先采用替换加密算法Md5Replace加密MD5算法密文,隐藏MD5算法密文的特征;再选定替换加密密文中某一位置插入由随机函数算法Md5Random产生定长的字符串得到最后的密文,改变了替换加密密文位数,隐藏了替换加密算法替换规律.在不改变算法效率的前提下,提高算法安全强度.

  2. MD5碰撞攻击的差分路径构建%Constructing Differential Path in MD5 Collision Attack

    Institute of Scientific and Technical Information of China (English)

    刘凡保; 谢涛

    2009-01-01

    著名的杂凑算法MD5是MD4的增强版本,由Ronald L.Rivest在1991年设计.MD5广泛应用于口令变换、数据完整性、数字证书等领域.近年最具影响的MD5安全性的分析结果是王小云首次发现的MD5碰撞.之后,MD5碰撞攻击的改进主要集中在提高碰撞对搜索的性能.基于新的不同于王小云的明文差分构成的MD5碰撞,介绍差分路径的构建方法,并给出一条差分路径以及碰撞对数据.

  3. Luminosity Anti-leveling with Crossing Angle (MD 1669)

    CERN Document Server

    Gorzawski, Arkadiusz; Ponce, Laurette; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; CERN. Geneva. ATS Department

    2016-01-01

    A significant fraction of the LHC luminosity ($\\sim$30\\% in 2016) is lost due to the presence (and necessity) of the crossing angles at the IPs. At the LHC the crossing angle is typically set to a value that provides sufficient separation of the beams at the start of fills for the peak bunch intensities. As the bunch intensity decays during a fill, it is possible to reduce the crossing angle and recover some luminosity. A smooth crossing angle reduction procedure must be developed to take advantage of this option during stable beam operation. During this MD a smooth procedure for luminosity leveling with crossing angle was tested. It was demonstrated that the orbit was well controlled, beam losses were low and the offset leveled experiments ALICE and LHCb were not affected by crossing angle leveling in ATLAS and CMS.

  4. The Achromatic Telescopic Squeezing (ATS) MD part II

    CERN Document Server

    Fartoukh, S; De Maria, R; Miyamoto, R; Mueller, G; Ponce, L; Redaelli, S; Strzelczyk, M; Tomas, R; Vanbavinckhove, G; Wenninger, J; Albert, M; Giachino, R; Giovannozzi, M; Goddard, B; Hagen, P; Hofle, W; Kain, V; Macpherson, A; Normann, L; Papotti, G; Steinhagen, R; Valuch, D; wollman, D

    2011-01-01

    This note describes the results obtained during the second so-called ATS MD where the record of Beta* was reached at IP1 and IP5 with a “pre-squeezed” Beta* of 1.2 m, while perfectly controlling the chromatic aberrations induced (non-linear chromaticity, off-momentum Beta-beating). Then, the ATLAS insertion was squeezed further down to the target of the former LHC Upgrade Project (Phase I), that is to Beta* = 30 cm, using the Achromatic Telescopic Squeezing techniques. In view of this major achievement, the bar is fixed even higher for the next ATS MD’s, with an ultimate Beta* targeted to 10 cm for the two high-luminosity insertions ATLAS and CMS.

  5. Emily Dickinson's ophthalmic consultation with Henry Willard Williams, MD.

    Science.gov (United States)

    Blanchard, Donald L

    2012-12-01

    Emily Dickinson is one of America's premier poets of the 19th century. Henry Willard Williams, MD, was one of the very first physicians to limit his practice to ophthalmology and was the established leader in his field in Boston, Massachusetts. They met during the time of the Civil War, when Emily consulted him about her ophthalmic disorder. No records of the diagnosis survive. Photophobia, aching eyes, and a restriction in her ability to work up close were her main symptoms. Iritis, exotropia, or psychiatric problems are the most frequent diagnoses offered to explain her difficulties. Rather than attempt a definitive conclusion, this article will offer an additional possibility that Dr Williams likely considered (ie, hysterical hyperaesthesia of the retina). This was a common diagnosis at that time, although it has currently faded from use.

  6. A workshop on leadership for MD/PhD students

    Directory of Open Access Journals (Sweden)

    Mark D. Cannon

    2011-08-01

    Full Text Available Success in academic medicine requires scientific and clinical aptitude and the ability to lead a team effectively. Although combined MD/PhD training programs invest considerably in the former, they often do not provide structured educational opportunities in leadership, especially as applied to investigative medicine. To fill a critical knowledge gap in physician-scientist training, the Vanderbilt Medical Scientist Training Program (MSTP developed a biennial two-day workshop in investigative leadership. MSTP students worked in partnership with content experts to develop a case-based curriculum and deliver the material. In its initial three offerings in 2006, 2008, and 2010, the workshop was judged by MSTP student attendees to be highly effective. The Vanderbilt MSTP Leadership Workshop offers a blueprint for collaborative student-faculty interactions in curriculum design and a new educational modality for physician-scientist training.

  7. 报文摘要算法MD5的分析与改进

    Institute of Scientific and Technical Information of China (English)

    汪勋亮; 赵春霞; 郭剑辉

    2014-01-01

    MD5算法在数据加密方面有着广泛的应用,但是它无法抵御查字典攻击和差分等攻击。为此本文介绍了报文算法MD5和Base64算法,以及在两种算法的基础上提出了MD5的改进算法,以应对以上被攻击的缺陷。%MD5 encryption algorithm in the data has a wide range of applications,but it can not resist dictionary attacks and differential attacks.This paper introduces the MD5 message digest algorithm and Base64 algorithm,and two algorithms based on the proposed the improved MD5 algorithm,the effect is to deal with the above attack.

  8. Leonard F. Peltier, MD, PhD, 1920-2003.

    Science.gov (United States)

    Reckling, Frederick W; Lo Vecchio, Janolyn G; Reckling, JoAnn B

    2004-05-01

    Leonard F. Peltier, MD, PhD, was an orthopaedic surgeon, academician, administrator, laboratory investigator, historian, and mentor. His career spanned nearly six decades, beginning with graduate education at the University of Minnesota (UM) under the auspices of Owen H. Wangensteen, MD, PhD. In addition to obtaining a PhD in physiology in the UM Graduate School, he completed general and orthopaedic surgery residencies and attained board certification in each specialty. He served in the US Army Occupation Force Medical Corps in Germany just after World War II. In 1957, at 37 years old, he assumed the chairmanship of the orthopaedic training program at the University of Kansas. In 1971, he couldn't resist the opportunity to become one of the founding members of the "start-up" University of Arizona College of Medicine, accepting an appointment as chair of the new orthopaedic training program, where he remained until his retirement in 1990. He took clinical problems to the laboratory, and made important scientific contributions, particularly in the area of fat embolism and in using calcium sulfate (plaster of Paris) to fill bone defects. He served on governing boards of national professional organizations and presided over the American Association for the Surgery of Trauma from 1980-1981. Throughout his career, he was fascinated by, and published extensively in, the history of medicine arena. Known fondly as "the professor" to many of his residents and colleagues, he had a pragmatic, honest, upbeat, and often humorous approach to life's challenges, valuing personal integrity above other virtues. He explored various eclectic interests far beyond his professional contributions while maintaining his family as a central priority. With his exemplary productivity and interests in the surgical and laboratory sciences, history of medicine, appreciation of fine arts, and perceptive and effective interactions with family, friends, patients, and colleagues, the memory of Leonard

  9. The MD5 Technical Analysis and Improvement Measures%MD5技术解析及改进措施

    Institute of Scientific and Technical Information of China (English)

    窦立莉

    2010-01-01

    随着网络的迅速普及,信息加密技术的发展对保障网络安全有着重大的作用与意义.本文对MD5 这种单向加密算法进行了简要描述,对MD5 算法的原理进行了深入分析,并提出了MD5 码的多种改进措施.

  10. Alternatively spliced myeloid differentiation protein-2 (MD-2s) protein inhibits TLR4-mediated lung inflammation

    Science.gov (United States)

    Tumurkhuu, Gantsetseg; Dagvadorj, Jargalsaikhan; Jones, Heather D.; Chen, Shuang; Shimada, Kenichi; Crother, Timothy R.; Arditi, Moshe

    2014-01-01

    We previously identified a novel alternatively spliced isoform of human myeloid differentiation protein-2 (MD-2s) that competitively inhibits binding of MD-2 to TLR4 in vitro. Here we investigated the protective role of MD-2s in LPS-induced acute lung injury by delivering intracheally (i.t.) an adenovirus construct that expressed MD-2s (Ad-MD-2s). After adenovirus-mediated gene transfer, MD-2s was strongly expressed in lung epithelial cells and readily detected in bronchoalveolar lavage fluid (BALF). Compared to Ad-EV control mice, Ad-MD-2s delivery resulted in significantly less LPS-induced inflammation in the lungs, including less protein leakage, cell recruitment, and expression of proinflammatory cytokines and chemokines, such as IL-6, KC, and MIP-2. BALF from Ad-MD-2s mice transferred into lungs of naive mice before i.t. LPS challenge diminished pro-inflammatory cytokine levels. As house dust mite (HDM) sensitization is dependent on TLR4 and HDM Der p 2, a structural homolog of MD-2, we also investigated the effect of MD-2s on house dust mite (HDM)-induced allergic airway inflammation. Ad-MD-2s given before HDM sensitization significantly inhibited subsequent allergic airway inflammation after HDM challenge, including reductions in eosinophils, goblet cell hyperplasia, and IL-5 levels. Our study indicates that the alternatively spliced short isoform of human MD-2 could be a potential therapeutic candidate to treat human diseases induced or exacerbated by TLR4 signaling, such as Gram-negative bacterial endotoxin-induced lung injury and house dust mite-triggered allergic lung inflammation. PMID:25576596

  11. Searching High and Low: Prosodic Breaks Disambiguate Relative Clauses

    Science.gov (United States)

    Fromont, Lauren A.; Soto-Faraco, Salvador; Biau, Emmanuel

    2017-01-01

    During natural speech perception, listeners rely on a wide range of cues to support comprehension, from semantic context to prosodic information. There is a general consensus that prosody plays a role in syntactic parsing, but most studies focusing on ambiguous relative clauses (RC) show that prosodic cues, alone, are insufficient to reverse the preferred interpretation of sentence. These findings suggest that universally preferred structures (e.g., Late Closure principle) matter far more than prosodic cues in such cases. This study explores an alternative hypothesis: that the weak effect of prosody might be due to the influence of various syntactic, lexical-semantic, and acoustic confounding factors, and investigate the consequences of prosodic breaks while controlling these variables. We used Spanish RC sentences in three experimental conditions where the presence and position (following the first or second noun phrase) of prosodic breaks was manipulated. The results showed that the placement of a prosodic break determined sentence interpretation by changing the preferred attachment of the RC. Listeners’ natural preference for low attachment (in the absence of break) was reinforced when a prosodic break was placed after the first noun. In contrast, a prosodic break placed after the second noun reversed the preferred interpretation of the sentence, toward high attachment. We argue that, in addition to other factors, listeners indeed use prosodic breaks as robust cues to syntactic parsing during speech processing, as these cues may direct listeners toward one interpretation or another. PMID:28203214

  12. Santa Claus visited CERN on Saturday, 3 December!

    CERN Document Server

    Staff Association

    2016-01-01

    Ever since its creation, the Staff Association has organised an annual Children’s Christmas Party. This party brings together 5- to 7-year-old children of employed members of the personnel. On Saturday, 3 December, the Staff Association welcomed no less than 230 children who attended with joy and enthusiasm a magical clown show presented at 13.30 and 15.30. After the show, they were offered a snack in Restaurant 1. We would like to thank Novae for their generous contribution, as well as their personnel for their valuable help. Then, Santa Claus himself came to hand out presents to the children. The Staff Association would also like to warmly thank him for despite his busy schedule for the season, he took the time to bring happiness and joy to little ones and older ones alike! Finally, we would like to thank all the parents who volunteered to help look after the children. Their presence and contribution are indispensable for the success of the party. This year, the Staff Association’s organ...

  13. Application of‘Division’in E-C Translation of Long and Complex At-tributive Clauses

    Institute of Scientific and Technical Information of China (English)

    YANG Cen

    2016-01-01

    The attributive clause plays a significant role in E-C translation. Due to the stylistic difference in Chinese and English (Chinese is paratactic while English is hypotactic), complex English attributive clauses cannot be translated literally as awkward-ness may occur. One possible approach to coping with the problem is the adoption of‘Division’in translating long English at-tributive clauses. This essay provides three steps in translating complex English attributive clauses into Chinese (clarifying mean-ing units, restructuring and polishing) and the accompanied techniques such as amplification and omission to make the transla-tion more readable and natural to Chinese readers.

  14. Iterative redundant encryption based on MD5 algorithm%基于MD5的迭代冗余加密算法

    Institute of Scientific and Technical Information of China (English)

    王津涛; 覃尚毅; 王冬梅

    2007-01-01

    MD5报文摘要算法是一种非常流行的加密方案,是对任意长度的消息提取数字指纹或消息摘要的算法,但是,在计算上难以提供两个具有相同数字指纹的不同消息,并难以由给定的数字指纹推算出相应的消息.基于MD5的迭代冗余加密算法对MD5算法进行了扩展,利用了MD5算法的强大安全性,实现了文件加密、解密和数据完整性保护的功能.

  15. MD5算法的过程分析及其C#实现%Process Analysis of MD5 Algorithm and Its C# realization

    Institute of Scientific and Technical Information of China (English)

    杜昌钰

    2008-01-01

    文章对MD5即"Message-Digest Algorithm 5(报文流行的C#对8D5算法进行了具体的实现,给出了一个具体的C#加密实例.虽然MD5因王小云教授在2004国际密码学会议(Crypto'2004)上发表的论文受到了前所未有的冲击,但MD5在一些非关键领域应用还是相当广泛.最后还提出了一些针对MD5现状的解决对策和建议.

  16. ASP网站用户帐号的MD5加密技术%The Encryption Techniques of MD5 about User Accounts in ASP Web

    Institute of Scientific and Technical Information of China (English)

    田文艳

    2007-01-01

    本文介绍了Asp中的MD5(Message-Digest Algorithm 5)加密技术,分析了它的工作原理及使用过程,并通过具体的使用实例,说明了MD5加密技术在网站开发中的具体实现方法.

  17. 一种使MD5算法产生更强雪崩效应的方法%Generating stronger avalanche effect in MD5 algorithm

    Institute of Scientific and Technical Information of China (English)

    张鑫彦; 闫德勤

    2010-01-01

    通过研究不同的差分分析对MD5算法的攻击后发现,差分分析攻击之所以可以成功,是因为在MD5算法中改变了明文中一些特定位,而这些特定位的改变在许多轮中最多只影响链接变量的几个位,并且这些小的差分能在随后的多轮操作中得到纠正,从而产生了碰撞.这就说明原MD5算法的雪崩效应不能阻止差分分析的攻击,而为了提高MD5算法的安全性,必须提高其雪崩效应的敏感性.分析结果表明,用动态明文变化函数对MD5算法进行修改,能使其产生更敏感的雪崩效应,以此来有效防止差分分析攻击,提高MD5算法的安全性.

  18. A super-high throughput implementation of MD5 algorithm on FPGA%超高吞吐量MD5算法的FPGA实现

    Institute of Scientific and Technical Information of China (English)

    王臣; 袁焱

    2011-01-01

    In this paper, a novel architecture is proposed to increase the performance of MD5 computing in FPGA , which can achieve a super-high throughput. The scheme is based on full-pipeline for MD5 implementation. Moreover, FIFO cache structure is used for data storage and cooperative computing. The results of simulation and implementation show that the scheme can achieve the theoretical upper bound on throughput. And based on the same platform of FPGA, it outperforms the published scheme with best performance in terms of 77% higher throughput.%为了提高MD5算法在FPGA中实现的运算效率,使之达到超高的数据吞吐量,提出了一种新的全流水线架构,用于实现MD5算法.架构中使用了FIFO缓存存储数据,以配合流水线的运算.实验验证其达到了单个MD5运算单元运算吞吐量的理论上限,在相同芯片平台上,超过已发表的MD5运算模块最高吞吐量的77%.

  19. An audit questionnaire that examines specifically the management of technical activities clauses in ISO 15189.

    Science.gov (United States)

    Hartley, T F

    2010-01-01

    The aim of this study was to design an audit questionnaire that focuses on the management of the technical activities in a Diagnostic Pathology Laboratory. The ISO 15189 Standard is written in such a way that it continually moves back and forth from topics where the auditor needs to question bench level staff, to topics where the auditor needs to question Technical Management Staff. This makes for a disjointed audit process - both Bench Staff and Technical Managers are repeatedly interrupted. The solution was to do a clause by clause analysis of the Standard and assign the major responsibility for the compliance to each clause to either Technical Managers or Bench Staff. The Clauses were then grouped under four topic headings regardless of whether they were a Section 4 or Section 5 Clause. Two questionnaires have emerged - the one described in this work and one directed primarily towards the activities of bench staff. There are 95 questions and it takes approximately two hours to complete.

  20. Clause/Term Resolution and Learning in the Evaluation of Quantified Boolean Formulas

    CERN Document Server

    Giunchiglia, E; Tacchella, A; 10.1613/jair.1959

    2011-01-01

    Resolution is the rule of inference at the basis of most procedures for automated reasoning. In these procedures, the input formula is first translated into an equisatisfiable formula in conjunctive normal form (CNF) and then represented as a set of clauses. Deduction starts by inferring new clauses by resolution, and goes on until the empty clause is generated or satisfiability of the set of clauses is proven, e.g., because no new clauses can be generated. In this paper, we restrict our attention to the problem of evaluating Quantified Boolean Formulas (QBFs). In this setting, the above outlined deduction process is known to be sound and complete if given a formula in CNF and if a form of resolution, called Q-resolution, is used. We introduce Q-resolution on terms, to be used for formulas in disjunctive normal form. We show that the computation performed by most of the available procedures for QBFs --based on the Davis-Logemann-Loveland procedure (DLL) for propositional satisfiability-- corresponds to a tree...

  1. 腰果酚二醚曼尼希碱固化剂的合成及其相分离现象研究%Synthesis and Phase Separation Phenomena of Cardanol Diethers-Mannich Base Curing Agent

    Institute of Scientific and Technical Information of China (English)

    宋健; 李梅; 李守海; 黄坤; 夏建陵

    2016-01-01

    The cardanol diethers (CDE) was obtained from Williamson etherification of cardanol(CD) and 1,3-dibromopropane.Then the cardanol diethers-Mannich baseas curing agent (MBCDE) for epoxy resins was prepared from the Mannich reaction of CDE, paraformadehyde and diethylenetriamine.The chemical structure was confirmed by FT-IR and 1H NMR.N-Aminoethylpiperazine (AEP) was chose as a control to investigate the toughening properties of MBCDE.Thermogravimetric analysis (TGA), scanning electronic microscopy (SEM) and mechanical properties of the cured epoxies were also conducted to investigate the properties of the bisphenol A epoxy resin (DGEBA) cured by two curing agents.The TGA results showed that the maximum decomposition temperature of MBCDE was 351.6 ℃ and the sample had good thermal stability.The impact strength of cured AEP/DGEBA was 3.641 J/m, while the cured 80% MBCDE sample had an impact strength of 5.155 J/m, which was improved by 41.6%.SEM results indicated that there was phase seperation in the cured materials contained MBCDE.%腰果酚(CD)和1,3-二溴丙烷经Williamson醚化反应得到一种腰果酚二醚化合物(CDE),然后以CDE、多聚甲醛和二乙烯三胺为原料,经Mannich反应制备得到一种浅色的腰果酚二醚曼尼希碱固化剂(MBCDE).通过傅里叶红外光谱(FT-IR)和核磁共振氢谱(1H NMR)表征了产物的化学结构,并与氨乙基哌嗪(AEP)进行对比研究其相关性能.通过热重分析(TGA)、扫描电镜(SEM)和力学性能测试研究了两种固化剂与双酚A环氧树脂(DGEBA)固化材料的相关性能.结果表明:MBCDE/DGEBA的最大分解温度为351.6 ℃,具有良好的热稳定性.AEP/DGEBA环氧固化物的冲击强度为3.641 J/m,而添加80%的MBCDE后固化物的冲击强度则为5.155 J/m,提高了41.6%.SEM分析结果表明MBCDE固化材料中存在相分离.

  2. 76 FR 48898 - Robert Leigh Kale, M.D., Decision and Order

    Science.gov (United States)

    2011-08-09

    ... Enforcement Administration Robert Leigh Kale, M.D., Decision and Order On September 9, 2010, the Deputy... Show Cause to Robert Leigh Kale, M.D. (Registrant), of Fort Smith, Arkansas. ] The Show Cause Order....100(b) and 0.104, I order that DEA Certificate of Registration, BK9514375, issued to Robert Leigh...

  3. 76 FR 50950 - Drawbridge Operation Regulation; Isle of Wight (Sinepuxent) Bay, Ocean City, MD

    Science.gov (United States)

    2011-08-17

    ... (Sinepuxent) Bay, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The... of Wight (Sinepuxent) Bay, mile 0.5, at Ocean City, MD. The proposed change will alter the dates the... will then become highlighted in blue. In the ``Document Type'' drop down menu select ``Proposed...

  4. 76 FR 17672 - Alfred E. Boyce, M.D.; Decision and Order

    Science.gov (United States)

    2011-03-30

    ... Enforcement Administration Alfred E. Boyce, M.D.; Decision and Order On August 12, 2010, Administrative Law....100(b) and 0.104, I order that DEA Certificate of Registration, FB0003943, issued to Alfred E. Boyce, M.D., be, and it hereby is, revoked. I further order that any pending application of Alfred E....

  5. A Study of L1 Transfer on the Use of Attributive Clauses In English Writing%A Study of L1 Transfer on the Use of Attributive Clauses In English Writing

    Institute of Scientific and Technical Information of China (English)

    边宛

    2011-01-01

    This study is carried out to find out the role of LI transfer on the problems of attributive clauses. By the application of Contrastive Analysis and Error Analysis, the study shows, Chinese belongs to the left-branching language, while English is the right- branching one in terms of the structure of attributive clauses.

  6. MD#1182: Calibration of diamond particle detectors in IP6

    CERN Document Server

    Valette, Matthieu; Lindstrom, Bjorn Hans Filip; Wiesner, Christoph

    2017-01-01

    In case of an asynchronous beam dump with a fully filled LHC machine it is expected that all standard ionisation chamber Beam Loss Monitors (IC BLM) around the LHC dumping region in IP6 will be saturated. Diamond Beam Loss Monitors (dBLM) were therefore installed next to the movable dump protection absorber (TCDQ) downstream of the extraction kickers. These detectors allow resolving losses at a nanosecond timescale and with an dynamic range of several orders of magnitude; thus, allowing to know the number of nominal bunches impacting the TCDQ. After a first series of calibrations using asynchronous beam dump tests, an experiment was conducted during MD#1182 to demonstrate the possibility of resolving a nominal bunch hitting the TCDQ. The impact parameter of the bunches on the TCDQ was first scanned using probe bunches with lower intensity then tests were done with nominal bunches (1.1e11 p/bunch) at injection energy. High energy calibration of the losses was also attempted unsuccessfully. Due to different beh...

  7. H5MD: a structured, efficient, and portable file format for molecular data

    CERN Document Server

    de Buyl, Pierre; Höfling, Felix

    2013-01-01

    We propose a new open file format named "H5MD" for storing molecular simulation data such as trajectories of particle positions and velocities as well as thermodynamic observables that are tracked during the course of the simulation. H5MD files are HDF5 (Hierarchical Data Format) files with a specific hierarchy and naming scheme. Thus, H5MD inherits many benefits of HDF5, e.g., structured layout of multi-dimensional data sets, data compression, fast and parallel I/O, and portability across many programming languages and hardware platforms. H5MD files are self-contained, and foster the reproducibility of scientific data and the interchange of data between researchers using different simulation programs and analysis software. In addition, the H5MD specification can serve for other kinds of data (e.g. experimental data) and is extensible to supplemental data without breaking the compliance of the file to the specification.

  8. PHP中的MD5加密机制探究

    Institute of Scientific and Technical Information of China (English)

    党长青

    2014-01-01

    MD5广泛用于加密和解密技术上。现阶段,存在两种加密方式,双向加密和单向加密。MD5是在Web应用程序中最常用的密码加密算法。由于MD5是不可逆的,因而经过MD5计算得到后的密文,不能通过逆向算法得到原文。在PHP应用程序中使用MD5加密文本密码的初衷,就是为了防止数据库中保存的密码不幸泄露后被直接获得。

  9. Md1 and Rp105 regulate innate immunity and viral resistance in zebrafish.

    Science.gov (United States)

    Candel, Sergio; Sepulcre, María P; Espín-Palazón, Raquel; Tyrkalska, Sylwia D; de Oliveira, Sofía; Meseguer, José; Mulero, Victoriano

    2015-06-01

    TLR4 was the first TLR family member identified in mammals and is responsible for the activation of the immune response by bacterial LPS. Later, MD1 and RP105 were shown to form complexes that directly interact with the MD2-TLR4 complex, acting as physiological negative regulators of LPS signaling. Despite the general conservation of various TLR families from fish to mammals, several differences can be appreciated, such as the high tolerance of fish to LPS, the absence of the crucial accessory molecules Md2 and Cd14 for Tlr4 signaling in fish, the absence of Tlr4 in some fish species, and the confirmation that LPS does not signal through Tlr4 in zebrafish. The present study has identified the Rp105 and Md1 homologs in zebrafish, confirming (i) Rp105 and Tlr4 evolved from a common ancestor before the divergence between fish and tetrapods and (ii) the presence of Md1 in teleost fish and the lack of Md2, suggesting that the divergence of these accessory molecules occurred in the tetrapod lineage. Biochemical and functional studies indicate that Md1 binds both Rp105 and Tlr4 in zebrafish. Genetic inhibition of zebrafish Md1 and Rp105 reveals that Md1 or Rp105 deficiency impairs the expression of genes encoding pro-inflammatory and antiviral molecules, leading to increased susceptibility to viral infection. These results shed light on the evolutionary history of Md1 and Rp105 and uncover a previously unappreciated function of these molecules in the regulation of innate immunity.

  10. Development of Word Order in German Complement-Clause Constructions: Effects of Input Frequencies, Lexical Items, and Discourse Function

    Science.gov (United States)

    Brandt, Silke; Lieven, Elena; Tomasello, Michael

    2010-01-01

    We investigate the development of word order in German children's spontaneous production of complement clauses. From soon after their second birthday, young German children use both verb final complements with complementizers and verb-second complements without complementizers. By their third birthday they use both kinds of complement clauses with…

  11. 48 CFR 1812.301 - Solicitation provisions and contract clauses for the acquisition of commercial items. (NASA...

    Science.gov (United States)

    2010-10-01

    ... authorized for use in acquisitions of commercial items when required by the clause prescription: (A) 1852.214... contract clauses for the acquisition of commercial items. (NASA supplements paragraph (f)) 1812.301 Section... COMPETITION AND ACQUISITION PLANNING ACQUISITION OF COMMERCIAL ITEMS Solicitation Provisions and...

  12. 8 CFR 204.7 - Preservation of benefits contained in savings clause of Immigration and Nationality Act...

    Science.gov (United States)

    2010-01-01

    ... savings clause of Immigration and Nationality Act Amendments of 1976. 204.7 Section 204.7 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRANT PETITIONS Immigrant Visa Petitions § 204.7 Preservation of benefits contained in savings clause of Immigration and Nationality...

  13. 14 CFR 91.23 - Truth-in-leasing clause requirement in leases and conditional sales contracts.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Truth-in-leasing clause requirement in... OPERATING AND FLIGHT RULES General § 91.23 Truth-in-leasing clause requirement in leases and conditional... January 2, 1973, shall execute a written lease or contract and include therein a written...

  14. 46 CFR 308.536 - Declaration where failure to comply with Clause 21 was inadvertent, Form MA-314.

    Science.gov (United States)

    2010-10-01

    ... inadvertent, Form MA-314. 308.536 Section 308.536 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF... Insurance § 308.536 Declaration where failure to comply with Clause 21 was inadvertent, Form MA-314. An... sufficient to meet the requirements of Clause 21 of the Policy shall file this Declaration, Form...

  15. Infinitival before and after-clauses in European Portuguese: temporal and aspectual properties

    Directory of Open Access Journals (Sweden)

    Purificação Silvano

    2015-06-01

    Full Text Available The main goal of this paper is to discuss temporal and aspectual features of sentences with clauses introduced by the connectives antes de + Infinitivo (‘before’ + Infinitive and depois de + Infinitivo (‘after’ + Infinitive combined with situations in the Pretérito Perfeito in European Portuguese. Our discussion is based on the widespread view that these clauses are locating adverbials (cf. Kamp and Reyle (1993 with temporal information of anteriority, in the case of antes de, and posteriority, in the case of depois de. However, this analysis is not as straightforward as one would expect, because, while before-clauses consistently render the same temporal relation (of anteriority, after-clauses may convey a temporal relation of inclusion, in addition to the standard posteriority relation. We put forward the hypothesis that aspectual characteristics play an important role in these differences, insofar as allowing a temporal reading that at first sight is not predicted from the semantic nature of the connective. In order to maintain a uniform treatment of before and after-clauses with respect to their temporal features, accounting simultaneously for the differences that emerge in their linguistic behaviour, we claim, along with Beaver & Condoravdi (2003 and Condoravdi (2010, that the locating time interval provided by these clauses is bounded to the left, but not to the right, that is, what is focused is the initial frontier of the situation that provides the time interval, leaving the final one undetermined. Furthermore, we show that, although the temporal mechanisms are parallel, the interference of aspectual properties leads to interesting differences in the final interpretation of before and after-sentences.

  16. Effects of Charter Party Arbitration Clauses Under the New Turkish Commercial Code

    Directory of Open Access Journals (Sweden)

    Didem Algantürk Light

    2016-06-01

    Full Text Available The New Turkish Commercial Code has became effective on 1 July 2012. The new Code covers bareboat charterparty, time charterparty, voyage charterparty and contracts of carriage by sea which is defined in general terms. On the other hand, Turkey is the one of the conracting State of Convention on the Recognition and Enforcement of Foreign Arbitral Awards (New York Convention, 1958 as well as European Convention on International Commercial Arbitration, 1961. In this study, we will examine the effects of the charter party arbitration clauses under the new Turkish Commercial Code and discuss the characteristics of the clauses to be valid under Turkish Law.

  17. Den sene Derrida, eller: Er Claus Beck-Nielsen et spøgelse?

    DEFF Research Database (Denmark)

    Rösing, Lilian Munk

    2009-01-01

    This article is about hosting the ghost. In Spectres de Marx (1993) Derrida introduces the ghost which seems to condense in one figure the important themes of his late writings: the address, the other, the ethical turn, the event, the mourning, the reality of immateriality, the guest. The article...... turns to the paternal ghost from Shakespeare's Hamlet, as well as to the most ghost-like artist on the Danish contemporary art scene: Claus Beck-Nielsen, who some years ago declared himself dead. Is Claus Beck-Nielsen really a ghost? That is the question....

  18. Electroporation of archaeal lipid membranes using MD simulations.

    Science.gov (United States)

    Polak, Andraž; Tarek, Mounir; Tomšič, Matija; Valant, Janez; Ulrih, Nataša Poklar; Jamnik, Andrej; Kramar, Peter; Miklavčič, Damijan

    2014-12-01

    Molecular dynamics (MD) simulations were used to investigate the electroporation of archaeal lipid bilayers when subjected to high transmembrane voltages induced by a charge imbalance, mimicking therefore millisecond electric pulse experiments. The structural characteristics of the bilayer, a 9:91 mol% 2,3-di-O-sesterterpanyl-sn-glicerol-1-phospho-myo-inositol (AI) and 2,3-di-O-sesterterpanyl-sn-glicerol-1-phospho-1'(2'-O-α-D-glucosyl)-myo-inositol (AGI) were compared to small angle X-ray scattering data. A rather good agreement of the electron density profiles at temperatures of 298 and 343 K was found assessing therefore the validity of the protocols and force fields used in simulations. Compared to dipalmitoyl-phosphatidylcholine (DPPC), the electroporation threshold for the bilayer was found to increase from ~2 V to 4.3 V at 323 K, and to 5.2 V at 298 K. Comparing the electroporation thresholds of the archaeal lipids to those of simple diphytanoyl-phosphatidylcholine (DPhPC) bilayers (2.5 V at 323 K) allowed one to trace back the stability of the membranes to the structure of their lipid head groups. Addition of DPPC in amounts of 50 mol% to the archaeal lipid bilayers decreases their stability and lowers the electroporation thresholds to 3.8 V and 4.1 V at respectively 323 and 298 K. The present study therefore shows how membrane compositions can be selected to cover a wide range of responses to electric stimuli. This provides new routes for the design of liposomes that can be efficiently used as drug delivery carriers, as the selection of their composition allows one to tune in their electroporation threshold for subsequent release of their load.

  19. The Design of MD5 Algorithm against Exhaustion Code-breaking and Its Realization%MD5算法防穷举(冲撞)破译的设计及其实现

    Institute of Scientific and Technical Information of China (English)

    廖思周

    2006-01-01

    在对MD5算法做简单介绍的基础上,针对攻击者拥有巨大密码字典、原文/密文对照数据库,设计了MD5变换算法,是对现有的MD5算法的延伸,大大提高了现成MD5密文的安全性.

  20. MD5算法及在用户口令加密应用中的改进%The Improved MD5 Algorithm in the Encryption of User Passwords

    Institute of Scientific and Technical Information of China (English)

    高洪波; 马素萍

    2010-01-01

    MD5是一种非常优秀的加密算法,曾被大量公司和个人广泛使用.但随着科学技术的发展,MD5牢不可破的神话逐渐破灭.基于此,在分析MD5加密算法及其弱点的前提下,探讨了MD5的改进算法.

  1. Characterization of an Autophagy-related Gene MdATG8i from apple

    Directory of Open Access Journals (Sweden)

    Ping eWang

    2016-05-01

    Full Text Available Nutrient deficiencies restrict apple (Malus sp. tree growth and productivity in Northwest China. The process of autophagy, a conserved degradation pathway in eukaryotic cells, has important roles in nutrient-recycling and helps improve plant performance during periods of nutrient-starvation. Little is known about the functioning of autophagy-related genes (ATGs in apple. In this study, one of the ATG8 gene family members MdATG8i was isolated from M. domestica. MdATG8i has conserved putative tubulin binding sites and ATG7 interaction domains. A 1865-bp promoter region cloned from apple genome DNA was predicated to have cis-regulatory elements responsive to light, environmental stresses and hormones. MdATG8i transcriptions were induced in response to leaf senescence, nitrogen depletion, and oxidative stress. At cellular level, MdATG8i protein was expressed in the nucleus and cytoplasm of onion epidermal cells. Yeast two-hybrid tests showed that MdATG8i could interact with MdATG7a and MdATG7b. In Arabidopsis, its heterologous expression was associated with enhanced vegetative growth, leaf senescence, and tolerance to nitrogen- and carbon-starvation. MdATG8i-overexpressing ‘Orin’ apple callus lines also displayed improved tolerance to nutrient-limited conditions. Our results demonstrate that MdATG8i protein could function in autophagy in a conserved way, as a positive regulator in the response to nutrient-starvation.

  2. Osmotically and thermally isolated forward osmosis-membrane distillation (fo-md) integrated module for water treatment applications

    KAUST Repository

    Ghaffour, Noreddine

    2016-09-01

    An integrated forward osmosis-membrane distillation (FO-MD) module and systems and methods incorporating the module is disclosed providing higher efficiencies and using less energy. The FO-MD module is osmotically and thermally isolated. The isolation can prevent mixing of FO draw solution/FO permeate and MD feed, and minimize dilution of FO draw solution and cooling of MD feed. The module provides MD feed solution and FO draw solution streams that flow in the same module but are separated by an isolation barrier. The osmotically and thermally isolated FO-MD integrated module, systems and methods offer higher driving forces of both FO and MD processes, higher recovery, and wider application than previously proposed hybrid FO- MD systems.

  3. Classification of 5-Dimensional MD-Algebras Having Non-Commutative Derived Ideals

    CERN Document Server

    Vu, Le Anh; Nghia, Tran Thi Hieu

    2011-01-01

    The paper presents a subclass of the class of MD5-algebras and MD5-groups, i.e. five dimensional solvable Lie algebras and Lie groups such that their orbits in the co-adjoint representation (K-orbits) are orbits of zero or maximal dimension. The main result of the paper is the classification up to an isomorphism of all MD5-algebras with the non-commutative derived ideal. With this result, we have the complete classification of 5-dimensional solvable Lie algebras.

  4. MD5算法应用失败的思考

    Institute of Scientific and Technical Information of China (English)

    TC-XB

    2007-01-01

    MD5算法作为一种高强度的加密算法,被广泛的应用于软件的注册算法中。但是需要指明的是.尽管MD5本身非常强大.但是如果应用不当,那么对软件的保护效果是很难令人满意的。下面我就先说一种最常见的MD5应用失败的形式。

  5. Lactobacillus farciminis MD, a newer strain with potential for bacteriocin and antibiotic assay.

    Science.gov (United States)

    Halami, P M; Chandrashekar, A; Nand, K

    2000-03-01

    A native isolate Lactobacillus farciminis MD isolated from fermenting mushroom exhibited a high degree of sensitivity to the majority of the bacteriocins produced by strains of lactobacilli, leuconostoc and pediococci. Also, the efficacy of Lact. farciminis MD as a sensitive strain for antibiotic assay was established against different antibiotics including ampicillin, cefazoline, chloramphenicol and nitrofurantoin at concentrations of 30 microg each, showing an inhibition zone of 30 mm diameter. The high degree of sensitivity towards bacteriocins and antibiotics provide potential for the exploitation of Lact. farciminis MD in establishing very well-defined bacteriocin producers.

  6. The core competencies of James Marion Sims, MD.

    Science.gov (United States)

    Straughn, J Michael; Gandy, Roy E; Rodning, Charles B

    2012-07-01

    The concept of core competencies in graduate medical education was introduced by the Accreditation Council for Graduate Medical Education of the American Medical Association to semiquantitatively assess the professional performance of students, residents, practitioners, and faculty. Many aspects of the career of J. Marion Sims, MD, are exemplary of those core competencies: MEDICAL KNOWLEDGE: Author of the first American textbook related to gynecology. MEDICAL CARE: Innovator of the Sims' Vaginal Speculum, Sims' Position, Sims' Test, and vesico-/rectovaginal fistulorrhaphy; advocated abdominal exploration for penetrating wounds; performed the first cholecystostomy. PROFESSIONALISM: Served as President of the New York Academy of Medicine, the American Medical Association, and the American Gynecologic Society. INTERPERSONAL RELATIONSHIPS/COMMUNICATION: Cared for the indigent, hearthless, indentured, disenfranchised; served as consulting surgeon to the Empress Eugénie (France), the Duchess of Hamilton (Scotland), the Empress of Austria, and other royalty of the aristocratic Houses of Europe; accorded the National Order of the Legion of Honor. PRACTICE-BASED LEARNING: Introduction of silver wire sutures; adoption of the principles of asepsis/antisepsis; adoption of the principles of general anesthesia. SYSTEMS-BASED PRACTICE: Established the Woman's Hospital, New York City, New York, the predecessor of the Memorial Sloan-Kettering Center for the Treatment of Cancer and Allied Diseases; organized the Anglo-American Ambulance Corps under the patronage of Napoleon III. What led him to a life of clinical and humanitarian service? First, he was determined to succeed. His formal medical/surgical education was perhaps the best available to North Americans during that era. Second, he was courageous in experimentation and innovation, applying new developments in operative technique, asepsis/antisepsis, and general anesthesia. Third, his curiosity was not burdened by rigid

  7. Milestone report on MD potential development for uranium silicide

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Jianguo [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.; Zhang, Yongfeng [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.; Hales, Jason Dean [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.

    2016-03-01

    This report summarizes the progress on the interatomic potential development of triuranium-disilicide (U3Si2) for molecular dynamics (MD) simulations. The development is based on the Tersoff type potentials for single element U and Si. The Si potential is taken from the literature and a Tersoff type U potential is developed in this project. With the primary focus on the U3Si2 phase, some other U-Si systems such as U3Si are also included as a test of the transferability of the potentials for binary U-Si phases. Based on the potentials for unary U and Si, two sets of parameters for the binary U-Si system are developed using the Tersoff mixing rules and the cross-term fitting, respectively. The cross-term potential is found to give better results on the enthalpy of formation, lattice constants and elastic constants than those produced by the Tersoff mixing potential, with the reference data taken from either experiments or density functional theory (DFT) calculations. In particular, the results on the formation enthalpy and lattice constants for the U3Si2 phase and lattice constants for the high temperature U3Si (h-U3Si) phase generated by the cross-term potential agree well with experimental data. Reasonable agreements are also reached on the elastic constants of U3Si2, on the formation enthalpy for the low temperature U3Si (m-U3Si) and h-U3Si phases, and on the lattice constants of m-U3Si phase. All these phases are predicted to be mechanically stable. The unary U potential is tested for three metallic U phases (α, β, γ). The potential is found capable to predict the cohesive energies well against experimental data for all three phases. It matches reasonably with previous experiments on the lattice constants and elastic constants of αU.

  8. Application of MD5 Algorithm in Office Automation System%MD5算法在办公自动化系统中的应用

    Institute of Scientific and Technical Information of China (English)

    张智发

    2008-01-01

    该文对办公自动化系统面临的风险进行了分析,介绍了MD5算法的特点和原理,把MD5算法应用于办公自动化系统中,解决了密码保护、信息完整性验证和数字签名等安全问题, 并给出了具体实现方法.

  9. 一种基于MD5算法的B/S通信加密系统%A MD5-based B/S communication encryption system

    Institute of Scientific and Technical Information of China (English)

    申甲

    2010-01-01

    随着网络的全面应用,以Web方式对数据进行操作的安全问题日益突出.本文针对目前广泛应用的MD5(Message Digest 5)加密算法,深入分析了MD5算法加密原理及实现过程,并利用该算法设计实现一种基于B/S(Browser/Server)方式的通信加密系统,达到了信息保密的要求.

  10. 48 CFR 719.273-11 - Solicitation provision and contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Solicitation provision and contract clause. 719.273-11 Section 719.273-11 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS The U.S. Agency for...

  11. The Role of Working Memory and Contextual Constraints in Children's Processing of Relative Clauses

    Science.gov (United States)

    Wieghall, Anna R.; Altmann, Gerry T. M.

    2011-01-01

    An auditory sentence comprehension task investigated the extent to which the integration of contextual and structural cues was mediated by verbal memory span with 32 English-speaking six- to eight-year-old children. Spoken relative clause sentences were accompanied by visual context pictures which fully (depicting the actions described within the…

  12. 48 CFR 952.223 - Clauses related to environment, energy and water efficiency, renewable energy technologies...

    Science.gov (United States)

    2010-10-01

    ... environment, energy and water efficiency, renewable energy technologies, occupational safety, and drug-free workplace. 952.223 Section 952.223 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CLAUSES AND... related to environment, energy and water efficiency, renewable energy technologies, occupational...

  13. 48 CFR 728.313 - Contract clauses for insurance of transportation or transportation-related services.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses for insurance of transportation or transportation-related services. 728.313 Section 728.313 Federal Acquisition...) USAID is required by law to include language in all its direct contracts and subcontracts ensuring...

  14. 37 CFR 401.3 - Use of the standard clauses at § 401.14.

    Science.gov (United States)

    2010-07-01

    ... under a Cooperative Research and Development Agreement (CRADA) pursuant to the statutory authority of 15... example, if the justification relates to a particular field of use or market, the clause might be modified... when § 401.3(a)(2) is used, the determination shall also include an analysis justifying...

  15. Main Verb Versus Reduced Relative Clause Ambiguity Resolution in L2 Sentence Processing.

    Science.gov (United States)

    Juffs, Alan

    1998-01-01

    Investigated how adult learners of English-as-a-Second- Language (ESL) process sentences containing verbs that are temporarily ambiguous in interpretation between a main verb and a reduced relative clause. Seventeen Chinese, 17 Korean or Japanese, and 17 Romance learners with advanced ESL proficiency and a comparison group of 17 monolingual native…

  16. 78 FR 37980 - Defense Federal Acquisition Regulation Supplement: Solicitation Provisions and Contract Clauses...

    Science.gov (United States)

    2013-06-25

    ... has retained in the final rule the language at 252.244-7000(b), which is the same as FAR 52.244-6(c)(2... Comments Several respondents had editorial comments as to the language within the rule. Comment: One... the clause at 252.225-7008, Restriction on Acquisition of Specialty Metals, as prescribed in...

  17. 48 CFR 227.7009-3 - Additional clauses-contracts except running royalty contracts.

    Science.gov (United States)

    2010-10-01

    ...-contracts except running royalty contracts. 227.7009-3 Section 227.7009-3 Federal Acquisition Regulations...—contracts except running royalty contracts. The following clauses are examples for use in patent release and settlement agreements, and license agreements not providing for payment by the Government of a...

  18. 48 CFR 2945.403 - Rental-use and charges clause.

    Science.gov (United States)

    2010-10-01

    ... clause. 2945.403 Section 2945.403 Federal Acquisition Regulations System DEPARTMENT OF LABOR CONTRACT MANAGEMENT GOVERNMENT PROPERTY Contractor Use and Rental of Government Property 2945.403 Rental-use and... property, as prescribed in FAR 45.403(a)....

  19. Reaction Mechanism for m-Xylene Oxidation in the Claus Process by Sulfur Dioxide.

    Science.gov (United States)

    Sinha, Sourab; Raj, Abhijeet; Al Shoaibi, Ahmed S; Chung, Suk Ho

    2015-09-24

    In the Claus process, the presence of aromatic contaminants such benzene, toluene, and xylenes (BTX), in the H2S feed stream has a detrimental effect on catalytic reactors, where BTX form soot particles and clog and deactivate the catalysts. Among BTX, xylenes are proven to be most damaging contaminant for catalysts. BTX oxidation in the Claus furnace, before they enter catalyst beds, provides a solution to this problem. A reaction kinetics study on m-xylene oxidation by SO2, an oxidant present in Claus furnace, is presented. The density functional theory is used to study the formation of m-xylene radicals (3-methylbenzyl, 2,6-dimethylphenyl, 2,4-dimethylphenyl, and 3,5-dimethylphenyl) through H-abstraction and their oxidation by SO2. The mechanism begins with SO2 addition on the radicals through an O-atom rather than the S-atom with the release of 180.0-183.1 kJ/mol of reaction energies. This exothermic reaction involves energy barriers in the range 3.9-5.2 kJ/mol for several m-xylene radicals. Thereafter, O-S bond scission takes place to release SO, and the O-atom remaining on aromatics leads to CO formation. Among four m-xylene radicals, the resonantly stabilized 3-methylbenzyl exhibited the lowest SO2 addition and SO elimination rates. The reaction rate constants are provided to facilitate Claus process simulations to find conditions suitable for BTX oxidation.

  20. Case Markers in Mongolian: A Means for Encoding Null Constituents in Noun Phrase and Relative Clause

    Science.gov (United States)

    Otgonsuren, Tseden

    2017-01-01

    This paper focuses on the capacity of the case markers in the Mongolian language, as a relative element, to generate any finite noun phrase or relative clause based on their syntactic function or relationship. In Mongolian, there are two different approaches to generate noun phrases: parataxis and hypotaxis. According to my early observation, if…

  1. The Acquisition of Relative Clauses in Spontaneous Child Speech in Mandarin Chinese

    Science.gov (United States)

    Chen, Jidong; Shirai, Yasuhiro

    2015-01-01

    This study investigates the developmental trajectory of relative clauses (RCs) in Mandarin-learning children's speech. We analyze the spontaneous production of RCs by four monolingual Mandarin-learning children (0;11 to 3;5) and their input from a longitudinal naturalistic speech corpus (Min, 1994). The results reveal that in terms of the…

  2. 75 FR 32642 - Defense Federal Acquisition Regulation Supplement; Ground and Flight Risk Clause (DFARS Case 2007...

    Science.gov (United States)

    2010-06-08

    ... Acquisition Regulation Supplement; Ground and Flight Risk Clause (DFARS Case 2007-D009) AGENCY: Defense... final rule amending the Defense Federal Acquisition Regulation Supplement (DFARS) to revise and combine... disadvantage small businesses. Most of the small businesses participating in these contracts do so as...

  3. Cognitive State Verbs and Complement Clauses in Children with SLI and Their Typically Developing Peers

    Science.gov (United States)

    Van Horne, Amanda J. Owen; Lin, Shanju

    2011-01-01

    This study investigated the use of cognitive state verbs (CSVs) and complement clauses in children with specific language impairment (SLI) and their typically developing (TD) peers. In Study 1, conversational samples from 23 children with SLI (M = 6;2), 24 age-matched TD children (M = 6;2) and 21 vocabulary-matched TD children (M = 4;9) were…

  4. Development and industrial application of catalyzer for low-temperature hydrogenation hydrolysis of Claus tail gas

    OpenAIRE

    Honggang Chang; Ronghai Zhu; Zongshe Liu; Jinlong He; Chongrong Wen; Sujuan Zhang; Yang Li

    2015-01-01

    With the implementation of more strict national environmental protection laws, energy conservation, emission reduction and clean production will present higher requirements for sulfur recovery tail gas processing techniques and catalyzers. As for Claus tail gas, conventional hydrogenation catalyzers are gradually being replaced by low-temperature hydrogenation catalyzers. This paper concentrates on the development of technologies for low-temperature hydrogenation hydrolysis catalyzers, prepar...

  5. Force majeure clauses and the threat of nuclear disaster. A Japanese case study

    Energy Technology Data Exchange (ETDEWEB)

    Guderian, Stephan Michael

    2011-07-22

    Force majeure clauses can be found in any commercial contract. Though more or less clear guidelines for the applicability of force majeure (clauses) exist in the form of international and national law, the applicability and enforceability of force majeure clauses with respect to nuclear incidents or disasters, however, remain ambiguous. Until the Japanese nuclear disaster, no major trade region was affected by any of the historical nuclear incidents. This case-study is based on the events surrounding the Tohoku earthquake, respective tsunami and nuclear incidents, especially at the Daiichi NPP and radiological contamination released there. The applicability and enforceability of force majeure clauses with their wide legal and economical implications are analyzed and evaluated according to the CISG and national domestic Japanese law. It is found that the assertion of force majeure is generally highly fact-specific and circumstance-sensitive. In general, the potential of nuclear disaster as an event triggering the force majeure defence is clearly evident, according to both international and Japanese law. Any claim must, however, be substantiated according to the principles of the different legal regimes under which the contract falls. In consequence, a company located within the evacuated areas will probably be able to successfully assert for majeure, whilst the success of any other claim will depend on the presentation of evidence, such as radiation levels and its effects in hindering performance of contractual obligations.

  6. An Inplementation of Pure Horn Clause Logic Programming in a Reduction System

    Institute of Scientific and Technical Information of China (English)

    许满武

    1993-01-01

    Many reduction systems have been presented for implementing functional programming languages.We propose here an extension of a reduction architecture to realize a kind of logic programming-pure Horn clause logic programming.This is an attempt to approach amalgamation of the two important programming paradigms.

  7. Material Adverse Effect Clause – Proper Legal Work or Contribution to False Sense of Security?

    DEFF Research Database (Denmark)

    Fomcenco, Alex

    2014-01-01

    Regardless of whether you are a buyer or a seller, and regardless what the object of the contract is, it is essentially important that you seek to protect your rights through various clauses that must aim to provide clearness to contractual obligations, defini- tions of breach, and consequences...

  8. The Meaning of Mood – Embedded Clauses in Spanish as a Case in Point

    DEFF Research Database (Denmark)

    Jensen, Helle Dam

    2011-01-01

    to be the result of an interpretive process. This article explains how mental space theory can be used in an analysis of mood in embedded clauses in Spanish. It starts from the assumption that the meaning of mood is constructed by interlocutors in an interpretive process on the basis of information from the modal...

  9. Working Memory Effects in the L2 Processing of Ambiguous Relative Clauses

    Science.gov (United States)

    Hopp, Holger

    2014-01-01

    This article investigates whether and how L2 sentence processing is affected by memory constraints that force serial parsing. Monitoring eye movements, we test effects of working memory on L2 relative-clause attachment preferences in a sample of 75 late-adult German learners of English and 25 native English controls. Mixed linear regression…

  10. Transfer in L3 Sentence Processing: Evidence from Relative Clause Attachment Ambiguities

    Science.gov (United States)

    Rah, Anne

    2010-01-01

    The present study investigates transfer effects in two groups of German learners of French for ambiguous relative clause (RC) constructions. The first learner group had started to learn French before English, whereas the second group had started to learn English before French. The RC attachment ambiguity is interesting to study possible transfer…

  11. The Acquisition of English Restrictive Relative Clauses by Arab Adult EFL Learners

    Directory of Open Access Journals (Sweden)

    Hayat Eid Alroudhan

    2016-02-01

    Full Text Available This study investigates the challenges faced by Arab adult learners of English as a foreign language (EFL in acquiring English restrictive relative clauses (RRCs, as well as the factors that affect the process of acquisition. This issue has received considerable attention in second language (L2 research. The present study discusses the syntactic structure of RRCs in English and Arabic with regard to the use of resumptive pronouns and the use of overt versus covert relative markers as related to the definiteness of the head noun. This study is carried out using an acceptability judgment test as the tool for data collection. A sample of 100 male and female adult Arabic speakers is used with the aim of identifying potential acquisition problems. The results obtained provide further support for first language (L1 transfer. This study concludes that participants accepted the use of resumptive pronouns and preferred the overt relative markers determined by definiteness. It is further discovered that certain factors influenced the acquisition process such as participants’ age, age of learning, and age of immersion. The current study has some pedagogical implications for the teaching of relative clauses in the EFL context.Keywords: English Relative Clauses, Restrictive Relative Clauses, Relative pronoun, Arab Learners of English

  12. Clause, Sentence, and Discourse Patterns in Selected Languages of Nepal: Part I, General Approach.

    Science.gov (United States)

    Hale, Austin

    This volume, the first in a series of four on the languages of Nepal, contains the following papers: "Toward the Systematization of Display Grammar,""Clause Patterns in Kham,""Tentative Systemic Organization of Nepali Sentences,""Maithili Sentences,""Notation for Simultaneous Representation of Grammatical and Sememic Components in Connected…

  13. A Corpus-based Approach to English Subordinate Clause I dentification

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The complex sentence structure of English is a bottleneck to our practical machi ne translation system. The simplification of English subordinate clauses will gr eatly relieves the burden of parsing and other grammatical or semantic analysis of a complex sentence, thus improves the output quality of the MT system. But th ere have not any satisfactory research achievements reported in this field up t o now as we know. In this paper, author's work on a corpus-based approach to English subordinate clause identification is reported. The approach integrate s rule-base d and statistical methods to get the left and right boundaries of the subordinat e clauses. The Penn Treebank corpus is used as the training standard. The precis ion and recall ratios of subordinate clause identification are tested on both cl osed and open corpora. A result of 92.9% precision and 91.26% recall is obtained for the closed test and the open test result is 80.34% precision and 83.93% rec all. This algorithm has been integrated into our machine translation system. The method can also be applied to processing of any other language.

  14. 48 CFR 225.7006-4 - Solicitation provision and contract clause.

    Science.gov (United States)

    2010-10-01

    ... and contract clause. (a) Use the provision at 252.225-7037, Evaluation of Offers for Air Circuit Breakers, in solicitations requiring air circuit breakers for naval vessels unless— (1) An exception... Breakers, in solicitations and contracts requiring air circuit breakers for naval vessels unless— (1)...

  15. 12 CFR Appendix B to Part 230 - Model Clauses and Sample Forms

    Science.gov (United States)

    2010-01-01

    ... mature in (time period). (ii) Early withdrawal penalties We impose a penalty if you withdraw of the... interest will remain on deposit until maturity. A withdrawal will reduce earnings. (iv) Renewal policies (1... for Change in Terms (Section 230.5(a)) B-3—Model Clauses for Pre-Maturity Notices for Time...

  16. 48 CFR 970.2703-1 - Purposes of patent rights clauses.

    Science.gov (United States)

    2010-10-01

    ... conducting privately funded technology transfer activities, involving the use of private funds to conduct licensing and marketing activities related to inventions made under the contract in accordance with the Bayh....5227-3. That clause also governs such activities as the distribution of royalties earned...

  17. The Acquisition of English Restrictive Relative Clauses by Arab Adult EFL Learners

    Science.gov (United States)

    Alroudhan, Hayat Eid

    2016-01-01

    This study investigates the challenges faced by Arab adult learners of English as a foreign language (EFL) in acquiring English restrictive relative clauses (RRCs), as well as the factors that affect the process of acquisition. This issue has received considerable attention in second language (L2) research. The present study discusses the…

  18. 48 CFR 337.103-70 - Solicitation provisions and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... Child Abuse, in solicitations, contracts, and orders that require performance on Federal land or in a... clause in 352.237-70, Pro-Children Act, in solicitations, contracts, and orders that involve (a... provided to children under the age of 18 on a routine or regular basis pursuant to the Pro-Children Act...

  19. 29 CFR 2580.412-19 - Term of the bond, discovery period, other bond clauses.

    Science.gov (United States)

    2010-07-01

    ... SECURITY ACT OF 1974 TEMPORARY BONDING RULES General Bond Rules § 2580.412-19 Term of the bond, discovery... 29 Labor 9 2010-07-01 2010-07-01 false Term of the bond, discovery period, other bond clauses... new bond must be obtained each year. There is nothing in the Act that prohibits a bond for a...

  20. 77 FR 50454 - Department of the Treasury Acquisition Regulations; Contract Clause on Minority and Women...

    Science.gov (United States)

    2012-08-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY 48 CFR Chapter 10 RIN 1505-AC40 Department of the Treasury Acquisition Regulations; Contract Clause on Minority and Women Inclusion in Contractor Workforce AGENCY: Departmental Offices,...

  1. Trojan Ponies: Undermining the Establishment Clause in the Name of "Child Benefit Theory."

    Science.gov (United States)

    Thurau-Gray, Lisa H.

    1998-01-01

    Two cases illustrate that whenever the schools or courts abandon the Establishment Clause and embrace "child benefit theory," religious schoolchildren are the only winners. Application of "child benefit theory" has engendered religious strife, increased public funds for religious schools, increased sectarian control of public…

  2. 12 CFR Appendix G to Part 226 - Open-End Model Forms and Clauses

    Science.gov (United States)

    2010-01-01

    ... problem with the quality of property or services that you purchased with a credit card, and you have tried... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Open-End Model Forms and Clauses G Appendix G to Part 226 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE...

  3. Frequency Affects Object Relative Clause Processing: Some Evidence in Favor of Usage-Based Accounts

    Science.gov (United States)

    Reali, Florencia

    2014-01-01

    The processing difficulty of nested grammatical structure has been explained by different psycholinguistic theories. Here I provide corpus and behavioral evidence in favor of usage-based models, focusing on the case of object relative clauses in Spanish as a first language. A corpus analysis of spoken Spanish reveals that, as in English, the…

  4. Sentence integration processes: An ERP study of Chinese sentence comprehension with relative clauses

    NARCIS (Netherlands)

    Yang, C.L.; Perfetti, C.A.; Liu, Y.

    2010-01-01

    In an event-related potentials (ERPs) study, we examined the comprehension of different types of Chinese (Mandarin) relative clauses (object vs. subject-extracted) to test the universality and language specificity of sentence comprehension processes. Because Chinese lacks morphosyntactic cues to sen

  5. Adding and Subtracting Alternation: Resumption and Prepositional Phrase Chopping in Spanish Relative Clauses

    Science.gov (United States)

    Cerron-Palomino Lopez, Alvaro

    2010-01-01

    This dissertation is a variationist account of two non-standard relative clause (RC) structures in Spanish: resumptive pronouns (RPs) and prepositional-phrase (PP) chopping. Previous typological studies considered RP explanations based on difficulty of processing (Hawkins, 1994), while Spanish-specific quantitative studies proposed a number of…

  6. Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling.

    Science.gov (United States)

    Gray, Pearl; Michelsen, Kathrin S; Sirois, Cherilyn M; Lowe, Emily; Shimada, Kenichi; Crother, Timothy R; Chen, Shuang; Brikos, Constantinos; Bulut, Yonca; Latz, Eicke; Underhill, David; Arditi, Moshe

    2010-06-01

    Myeloid differentiation factor 2 (MD-2) is a secreted gp that assembles with TLR4 to form a functional signaling receptor for bacterial LPS. In this study, we have identified a novel alternatively spliced isoform of human MD-2, termed MD-2 short (MD-2s), which lacks the region encoded by exon 2 of the MD-2 gene. Similar to MD-2, MD-2s is glycosylated and secreted. MD-2s also interacted with LPS and TLR4, but failed to mediate LPS-induced NF-kappaB activation and IL-8 production. We show that MD-2s is upregulated upon IFN-gamma, IL-6, and TLR4 stimulation and negatively regulates LPS-mediated TLR4 signaling. Furthermore, MD-2s competitively inhibited binding of MD-2 to TLR4. Our study pinpoints a mechanism that may be used to regulate TLR4 activation at the onset of signaling and identifies MD-2s as a potential therapeutic candidate to treat human diseases characterized by an overly exuberant or chronic immune response to LPS.

  7. 75 FR 68970 - Amendment of Using Agency for Restricted Areas R-4002, R-4005, R-4006 and R-4007; MD

    Science.gov (United States)

    2010-11-10

    ... Restricted Areas R-4002, R-4005, R- 4006 and R-4007; MD AGENCY: Federal Aviation Administration (FAA), DOT... restricted areas R-4002, Bloodsworth Island, MD; and R-4005, R-4006 and R-4007, Patuxent River, MD to ``U.S... areas R-4002, R-4005, R-4006 and R-4007 in Maryland, in order to reflect the correct......

  8. 76 FR 71371 - James L. Hooper, M.D.; Decision and Order

    Science.gov (United States)

    2011-11-17

    ... suitability to maintain a COR, not the Maryland Board. See Edmund Chein, M.D., 72 FR 6580, 6590 (2007... delegated exclusively to the DEA, not to entities within state government), aff'd, Chein v. DEA, 533...

  9. 好压的MD5校验功能

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    为了防止人为篡改文件.一般网上供网民下载的文件都公布了其MD5校验值,下载到本机后通过比较MD5校验值是否发生变化来判断文件是否被篡改。先选中文件,再点击好压软件“工具”菜单里的“MD5校验工具”就可查看到该文件的相关校验,可以对任意文件进行版本、文件时间、MD5值、SHAl值和CRC32值进行校验。

  10. MD5加密验证拿下

    Institute of Scientific and Technical Information of China (English)

    Crack

    2005-01-01

    在软件的加密保护中,MD5是一个经常会被用到的加密算法,但是由于MD5算法为不可逆算法所以所有的软件都只能使用MD5算法作为一个加密的中间步骤,比如对用户名做一个MD5变换,结果再进行一个可逆的加密变换,变换结果为注册码;

  11. 感受MD5暴力破解的魅力

    Institute of Scientific and Technical Information of China (English)

    冰河洗剑

    2005-01-01

    MD5密码一直是最头疼的,许多论坛和网站的密码都是MD5加密过的。当然得到了MD5加密过的密码后.有的高手可以通过Cookie欺骗或Session欺骗等方式.进入后台管理页面,但是对许多朋友来说,暴力破解MD5密码.将其还原为明文密码.再登录后台虽然有些笨.但却是比较简单有效的一种方法。

  12. 简单编写MD5破解器

    Institute of Scientific and Technical Information of China (English)

    人鱼姬

    2007-01-01

    目前国内的网络安全现状不容乐观.脚本注入还大有市场。许多脚本小子喜欢用注入工具到处乱注.拿到了管理员密码的MD5密文就开始破解,但并不是所有人都知道MD5破解是如何实现的。下面我们就用Delphi来编写一款简单的MD5破解器.同时让大家更清晰地了解MD5破解是基于什么原理实现的。

  13. 在线破解MD5网站一览

    Institute of Scientific and Technical Information of China (English)

    Tashanenjoy

    2006-01-01

    MD5加密因其不可逆性而导致了一些爆破猜测MD5工具的出现.如著名的MD5Crack.其原理是先进行MD5加密再对比提供的字符串。虽然速度也较快.但毕竟还是要“跑”一下具。有时一个密码跑30分钟也不一定能跑出来.很不划算。有没有其他的办法呢?

  14. 75 FR 10195 - Special Local Regulations for Marine Events; Chester River, Chestertown, MD

    Science.gov (United States)

    2010-03-05

    ... to establish special local regulations during the reenactment portion of the ``Chestertown Tea Party... Festival will sponsor a reenactment in the Chester River at Chestertown, MD. The key component of the...

  15. Collision Attack on the Full Extended MD4 and Pseudo-Preimage Attack on RIPEMD

    Institute of Scientific and Technical Information of China (English)

    Gao-Li Wang

    2013-01-01

    The cryptographic hash functions Extended MD4 and RIPEMD are double-branch hash functions,which consist of two parallel branches.Extended MD4 was proposed by Rivest in 1990,and RIPEMD was devised in the framework of the RIPE project (RACE Integrity Primitives Evaluation,1988~1992).On the basis of differential analysis and meet-in-the-middle attack principle,this paper proposes a collision attack on the full Extended MD4 and a pseudo-preimage attack on the full RIPEMD respectively.The collision attack on Extended MD4 holds with a complexity of 237,and a collision instance is presented.The pseudo-preimage attack on RIPEMD holds with a complexity of 2125,4,which optimizes the complexity order for brute-force attack.The results in this study will also be beneficial to the analysis of other double-branch hash functions such as RIPEMD-160.

  16. Comparison of time adjustment clauses between DZ3910, AS4000 and STCC

    Directory of Open Access Journals (Sweden)

    David Finnie

    2013-03-01

    Full Text Available This article examines time adjustment clauses, as they relate to time adjustment between standard terms of construction contracts. DZ3910, AS4000 and STCC were compared on the basis of how risks are allocated, how this may impact on the contractor’s pricing, and ease of understanding for each clause. ASTCC was found to be the most easily interpreted contract, followed by AS4000 and then NZS3910. These assessments were based on the following: a whether each contract contains words with multiple meanings, b the number of words used per sentence, c the amount of internal cross-referencing, and d the clarity of the contract structure. The allowable pre-conditions for the contractor to claim a time adjustment are similar for all three contracts, and none of them expressly state which party is to bare the risk of buildability, or address the risk of a designer’s disclaimer clause. All of the contracts adopt the principle of contra preferentum which means that the employer bares the risk of variance if there are any ambiguities in the design documentation. Due to their similarities of risk allocation, all of the contracts provide the employer with a similar amount of price surety. AS4000 is the only contract to contain a stringent time-bar clause, limiting a contractor’s time adjustment claim. ASTCC requires the contractor to apply ‘immediately’ and DZ3910 provides a time-bar of 20 working days or as soon as practicable. None of the contracts clarify whether their timing requirements take precedence over the prevention principle, or over any other ground for claiming a time adjustment. The effect of DZ3910’s pre-notification clause 5.19.3 is discussed, and an alternative contents structure is recommended for DZ3910, using a project management method.

  17. Sustainable water recovery from oily wastewater via forward osmosis-membrane distillation (FO-MD).

    Science.gov (United States)

    Zhang, Sui; Wang, Peng; Fu, Xiuzhu; Chung, Tai-Shung

    2014-04-01

    This study proposed and investigated a hybrid forward osmosis - membrane distillation (FO-MD) system for sustainable water recovery from oily wastewater by employing lab-fabricated FO and MD hollow fiber membranes. Stable oil-in-water emulsions of different concentrations with small droplet sizes (<1 μm) were firstly prepared and applied as the feed solution in the FO process. Fouling was immediately observed in the FO mode and was low on the cellulose triacetate (CTA) - based thin film composite (TFC) membranes. Moreover, slight increment of fouling was observed in the first few hours and the water flux was then stabilized over 24 h. The characterizations of water flux and solute rejection in separate FO and MD processes revealed that a high water flux, good NaCl rejection, impressively high retention of oil droplets and partial permeation of acetic acid could be achieved. Finally, an integrated FO-MD system was developed to treat the oily wastewater containing petroleum, surfactant, NaCl and acetic acid at 60 °C in the batch mode. The water flux in FO undergoes three-stage decline due to fouling and reduction in osmotic driving force, but is quite stable in MD regardless of salt concentration. Oily wastewater with relatively high salinity could be effectively recovered by the FO-MD hybrid system while maintaining large water flux, at least 90% feed water recovery could be readily attained with only trace amounts of oil and salts, and the draw solution was re-generated for the next rounds of FO-MD run. Interestingly, significant amount of acetic acid was also retained in the permeate for further reuse as a chemical additive during the production of crude oil. The work has demonstrated that not only water but also organic additives in the wastewater could be effectively recovered by FO-MD systems for reuse or other utilizations.

  18. 下载软件的MD5你检验了吗?

    Institute of Scientific and Technical Information of China (English)

    胥忠亮

    2009-01-01

    大家经常在网上下东西.可是下载下来的软件很有可能带有木马。通常软件发布者在发布软件的时候会附上软件的MD5.来防止软件被他人篡改。那程序的MD5值是什么呢?

  19. 软件保护中MD5算法的另类应用

    Institute of Scientific and Technical Information of China (English)

    TC—XB

    2006-01-01

    作为一种主流的加密算法,MD5算法广泛的应用于软件保护领域。在软件的注册保护中,MD5经常被用来对输入的注册信息进行加密。一般来说较为简单常见的用法是“MD5(注册名)=注册码”或是“MD5(注册名:机器码)=注册码”。这样的加密方法有一定的保护效果,但是随着破解技术的进步,对于这种保护方式,破解者只要能判断出使用了MD5算法,就可以很方便的做出注册机。不过不能因此否认MD5算法的优越性,所以对于MD5在软件的保护中应用,就要另辟蹊径了。下文中我们以一个Crackme为例,来看看如何更有效的使用MD5算法,并产生更好的保护效果。

  20. 不要宰牛刀,MD5值校对更方便

    Institute of Scientific and Technical Information of China (English)

    新玲的窗户

    2009-01-01

    在一些比较正规的网站或论坛下载软件时,在软件下载链接旁边一般都会提供该软件原始的MD5值。用MD5值工具计算出下载软件的MD5值,和原始MD5值进行校对,就可判断出下载的软件是否被修改过。但是,使用专门的工具对下载的软件进行MD5值校对比较麻烦,二来也有“杀鸡用牛刀”之嫌。其实,仅仅利用一个动态链接库文件,就可以完成MD5值的校对工作。

  1. 防止密码MD5值被破解妙招

    Institute of Scientific and Technical Information of China (English)

    晏伟

    2006-01-01

    现在的站点当中有很多密码都是经过MD5加密的,有很多人认为经过MD5加密后的密码就是安全的,即使密码MD5值被暴露也无所谓,殊不知有很多站点都能够对MD5值进行穷举解密,这些站点能够在瞬间还原1O位以下字母+数字+字符组合的密码。有些站点甚至声称数据库中有235亿条记录,这是件很可怕的事情,如果你的密码不够强大,只是由简单数字或几个字母组成,MD5值也相当于是明文!下面我就教大家一招防止MD5值被破解的妙招。

  2. Parallel Cascade Selection Molecular Dynamics (PaCS-MD) to generate conformational transition pathway.

    Science.gov (United States)

    Harada, Ryuhei; Kitao, Akio

    2013-07-21

    Parallel Cascade Selection Molecular Dynamics (PaCS-MD) is proposed as a molecular simulation method to generate conformational transition pathway under the condition that a set of "reactant" and "product" structures is known a priori. In PaCS-MD, the cycle of short multiple independent molecular dynamics simulations and selection of the structures close to the product structure for the next cycle are repeated until the simulated structures move sufficiently close to the product. Folding of 10-residue mini-protein chignolin from the extended to native structures and open-close conformational transition of T4 lysozyme were investigated by PaCS-MD. In both cases, tens of cycles of 100-ps MD were sufficient to reach the product structures, indicating the efficient generation of conformational transition pathway in PaCS-MD with a series of conventional MD without additional external biases. Using the snapshots along the pathway as the initial coordinates, free energy landscapes were calculated by the combination with multiple independent umbrella samplings to statistically elucidate the conformational transition pathways.

  3. Analysis and improvement of preimage attack on MD-4.%MD-4原象攻击的分析与改进

    Institute of Scientific and Technical Information of China (English)

    阎娜; 李梦东; 陈少晖

    2011-01-01

    首先分析了Leurent提出的MD-4原象攻击方法,该方法利用MD-4布尔函数的吸收性质,迭代函数的可逆性以及消息扩展方式的特殊性,首先形成伪原象攻击,之后利用基于树的方法将伪原象转变为原象攻击.采用随机图的方法,对其后一部分进行了改进,提高了攻击效率,将复杂度从2102降低到298.%The preimage attack of MD-4 is discussed. Leurent's method explores chiefly three properties of MD-4:The absorption properties of boolean function, reversibility of the iterative process and specificity of message expansion. After their pseudo preimage attack a tree-based method is followed to transform pseudo preimage to true preimage.Tree-basod method is replaced with random graph method. The complexity of the attack reduces to 298 from 2102.

  4. Cell lines, Md108 and Md66, from the hemocytes of Malacosoma disstria (Lepidoptera) display aspects of plasma-free innate non-self activities.

    Science.gov (United States)

    Lapointe, Jason F; Dunphy, Gary B; Giannoulis, Paschalis; Mandato, Craig A; Nardi, James B; Gharib, Osama H; Niven, Donald F

    2011-11-01

    The innate non-self response systems of the deciduous tree pest, the forest tent caterpillar, Malacosoma disstria has been documented by us in terms of in vitro and in vivo reactions towards the Gram-positive nonpathogenic bacterium, Bacillus subtilis and Gram-negative pathogenic microbe, Xenorhabdus nematophila and their respective surface antigens, lipopoteichoic acids (LTA) and lipopolysaccharides (LPS). These studies, often conducted in whole and diluted hemolymph, preclude examination of plasma-free cellular (hemocyte) responses. Plasma-free hemocytes as primary cultures are difficult to obtain. The floating cell line Md66 and attached cell line Md108 from M. disstria hemocytes were examined as a model for plasma-free M. disstria hemocyte non-self responses. Herein, it was established that although both lines differed from each other and from the primary hemocyte cultures of M. disstria in growth parameters, cell composition and sizes both cell lines displayed granular cell-like (GL) cells and plasmatocyte-like (PL) cells according to morphological criteria and to some extent antigenic similarities based on labeling with anti-Chrysodeixis includens hemocyte monoclonal antibodies. Hemocyte-specific neuroglian-like protein was detected on cells of both cell lines and in the primary hemocyte cultures albeit with staining patterns differing according to culture and cell types, confluency levels and cell-cell adhesion. Both cell lines bound B. subtilis and X. nematophila, the reaction extent varying with the cell line and its cell types. LPS damaged both cell types in the two cell lines whereas LTA enhanced the adhesion of Md66 GL cells to flask surfaces followed by PL cell adhesion. PL cells of both lines, like the primary cultures, phagocytosed FITC-labeled B. subtilis; only Md108 GL cells phagocytosed B. subtilis. In either case phagocytosis was always less in frequency and intensity than the primary cultures. Proteins released from the cell lines differed in

  5. Synthesis and Performance of Mannich Base Quaternary Ammonium Salt Acidizing Corrosion Inhibitor%曼尼希碱季铵盐酸化缓蚀剂的合成及性能

    Institute of Scientific and Technical Information of China (English)

    赵顺强; 孙永涛; 马增华; 付朝阳

    2014-01-01

    合成了一种新型的曼尼希碱季铵盐(BMQA)酸化缓蚀剂,通过静态失重法测试了缓蚀剂在不同浓度盐酸中的缓蚀性能。结果表明,90℃下,缓蚀剂 BMQA 在15%盐酸中加入0.1%,18%盐酸中加入0.2%,28%盐酸中加入0.5%,N80钢的腐蚀速率都能小于4 g·m-2·h-1。极化曲线测试表明该缓蚀剂是抑制阳极为主的混合型缓蚀剂,遵循 Langmuir 吸附等温式,能自发在金属表面进行化学吸附。%A new type of Mannich base quaternary ammonium salt was synthesized as an acidification corrosion inhibitor.The inhibition performance of this corrosion inhibitor was evaluated in hydrochloric acid with different concentrations by static weight loss method.The results showed that with 0.1% inhibitor in 15% hydrochloric acid, 0.2% inhibitor in 18% hydrochloric acid and 0.5% inhibitor in 28% hydrochloric acid,the corrosion rates of steel N80 were all lower than 4 g·m-2 ·h-1 at 90℃.Polarization curves indicate that the corrosion inhibitor is a mixed inhibitor but mainly prohibits the anodic corrosion process,obeys the Langmuir adsorption isothermal equation and can spontaneously absorb on the steel surface by chemisorption.

  6. 76 FR 19401 - Beau Boshers, M.D.; Decision and Order

    Science.gov (United States)

    2011-04-07

    ... (citing Hoxie v. DEA, 419 F.3d 477, 482 (6th Cir. 2005); Morall v. DEA, 412 F.3d 165, 173-174 (DC Cir. 2005). As I further explained, ``this is not a contest in which score is kept; the Agency is not... Due Process Clause. See, e.g., Goldberg v. Kelly, 397 U.S. 254, 270 (1970). In Goldberg, the...

  7. Novel matrine derivative MD-1 attenuates hepatic fibrosis by inhibiting EGFR activation of hepatic stellate cells.

    Science.gov (United States)

    Feng, Yi; Ying, Hai-Yan; Qu, Ying; Cai, Xiao-Bo; Xu, Ming-Yi; Lu, Lun-Gen

    2016-09-01

    Matrine (MT), the effective component of Sophora flavescens Ait, has been shown to have anti-inflammation, immune-suppressive, anti-tumor, and anti-hepatic fibrosis activities. However, the pharmacological effects of MT still need to be strengthened due to its relatively low efficacy and short half-life. In the present study, we report a more effective thio derivative of MT, MD-1, and its inhibitory effects on the activation of hepatic stellate cells (HSCs) in both cell culture and animal models. Cytological experiments showed that MD-1 can inhibit the proliferation of HSC-T6 cells with a half-maximal inhibitory concentration (IC50) of 62 μmol/L. In addition, MD-1 more strongly inhibits the migration of HSC-T6 cells compared to MT and can more effectively induce G0/G1 arrest and apoptosis. Investigating the biological mechanisms underlying anti-hepatic fibrosis in the presence of MD-1, we found that MD-1 can bind the epidermal growth factor receptor (EGFR) on the surface of HSC-T6 cells, which can further inhibit the phosphorylation of EGFR and its downstream protein kinase B (Akt), resulting in decreased expression of cyclin D1 and eventual inhibition of the activation of HSC-T6 cells. Furthermore, in rats with dimethylnitrosamine (DMN)-induced hepatic fibrosis, MD-1 slowed the development and progression of hepatic fibrosis, protecting hepatic parenchymal cells and improving hepatic functions. Therefore, MD-1 is a potential drug for anti-hepatic fibrosis.

  8. Current Tools and Methods in Molecular Dynamics (MD) Simulations for Drug Design.

    Science.gov (United States)

    Hernández-Rodríguez, Maricarmen; Rosales-Hernández, Martha C; Mendieta-Wejebe, Jessica E; Martínez-Archundia, Marlet; Basurto, José Correa

    2016-01-01

    Molecular Dynamics (MD) simulations is a computational method that employs Newton's laws to evaluate the motions of water, ions, small molecules, and macromolecules or more complex systems, for example, whole viruses, to reproduce the behavior of the biological environment, including water molecules and lipid membranes. Specifically, structural motions, such as those that are dependent of the temperature and solute/ solvent are very important to study the recognition pattern of ligandprotein or protein-protein complexes, in that sense, MD simulations are very useful because these motions can be modeled using this methodology. Furthermore, MD simulations for drug design provide insights into the structural cavities required to design novel structures with higher affinity to the target. Also, the employment of MD simulations to drug design can help to refine the three-dimensional (3D) structure of targets in order to obtain a better sampling of the binding poses and more reliable affinity values with better structural advantages, because they incorporate some biological conditions that include structural motions compared to traditional docking procedures. This work analyzes the concepts and applicability of MD simulations for drug design because molecular structural motions are considered, and these help to identify hot spots, decipher structural details in the reported protein sites, as well as to eliminate sites that could be structural artifacts which could be originated from the structural characterization conditions from MD. Moreover, better free energy values for protein ligand recognition can also be obtained, and these can be validated under experimental procedures due to the robustness of the MD simulation methods.

  9. Equivalent Key Recovery Attack on H2-MAC Instantiated with MD5%H2-MAC-MD5的等价密钥恢复攻击

    Institute of Scientific and Technical Information of China (English)

    王薇

    2012-01-01

    H2-MAC was proposed by Kan Yasuda in Information Security Conference (ISC) 2009, which is similar with HMAC except that the outer key is omitted, and gets rid of the disadvantage of the key management. This paper presents the first equivalent key recovery attack on H2-MAC-MD5, which conduces to a selective forgery attack directly, while there only is a distinguishing attack for HMAC-MD5. Based on the distinguisher of HMAC-MD5, a pair of intermediate chaining variables, i.e., the equivalent keys, is detected which fulfils the specific conditions on the initial variables of the pseudo-collision. Then the inner key recovery attack on HMAC-MD5 is adopted to recover the equivalent key. Consequently, the adversary can process the selective forgery attack by computing the valid MAC value of M0||M*effortlessly, where M0 is a fixed one-block message, and M*can be any bit strings. The complexity of the attack is about 297 queries, which is much lower than the ideal complexity of the selective forgery.%H2-MAC由Kan Yasuda在ISC 2009上提出,与HMAC的不同之处在于H2-MAC没有外部密钥,简化密钥管理。首次给出 H2-MAC-MD5的等价密钥恢复攻击,并进行选择性伪造。基于HMAC-MD5区分器和比特探测技术,筛选可能满足特殊伪碰撞路线的中间链接变量,即等价密钥,并恢复其数值,导致选择性伪造。即在不知道密钥的前提下,敌手可伪造消息M0||M*的合法MAC值,其中,M0为固定的512比特消息分组,M*为任意消息。攻击的复杂度为297次MAC查询,远低于选择性伪造攻击的理想复杂度。

  10. Angiotensin II induces kidney inflammatory injury and fibrosis through binding to myeloid differentiation protein-2 (MD2)

    Science.gov (United States)

    Xu, Zheng; Li, Weixin; Han, Jibo; Zou, Chunpeng; Huang, Weijian; Yu, Weihui; Shan, Xiaoou; Lum, Hazel; Li, Xiaokun; Liang, Guang

    2017-01-01

    Growing evidence indicates that angiotensin II (Ang II), a potent biologically active product of RAS, is a key regulator of renal inflammation and fibrosis. In this study, we tested the hypothesis that Ang II induces renal inflammatory injury and fibrosis through interaction with myeloid differentiation protein-2 (MD2), the accessory protein of toll-like receptor 4 (TLR4) of the immune system. Results indicated that in MD2−/− mice, the Ang II-induced renal fibrosis, inflammation and kidney dysfunction were significantly reduced compared to control Ang II-infused wild-type mice. Similarly, in the presence of small molecule MD2 specific inhibitor L6H21 or siRNA-MD2, the Ang II-induced increases of pro-fibrotic and pro-inflammatory molecules were prevented in tubular NRK-52E cells. MD2 blockade also inhibited activation of NF-κB and ERK. Moreover, MD2 blockade prevented the Ang II-stimulated formation of the MD2/TLR4/MyD88 signaling complex, as well as the increased surface binding of Ang II in NRK-52E cells. In addition, Ang II directly bound recombinant MD2 protein, rather than TLR4 protein. We conclude that MD2 is a significant contributor in the Ang II-induced kidney inflammatory injury in chronic renal diseases. Furthermore, MD2 inhibition could be a new and important therapeutic strategy for preventing progression of chronic renal diseases.

  11. Evaluation of hydroacid complex in the forward osmosis–membrane distillation (FO–MD) system for desalination

    KAUST Repository

    Wang, Peng

    2015-11-01

    The incorporation of membrane distillation (MD) into forward osmosis (FO) provides process sustainability to regenerate the draw solution and to produce clean water simultaneously. However, the reverse salt flux is the major hurdle in the FO-MD system because it not only reduces the effective osmotic driving force across the membrane but also increases the replenishment cost and scaling issue. For the first time, a hydroacid complex with abundant hydrophilic groups and ionic species is evaluated as the draw solutes in the hybrid FO-MD system consisting of multi-bore PVDF MD membranes for seawater/brackish desalination. In order to evaluate the practicality of the hydroacid complex in the FO-MD system, FO and MD experiments were conducted at elevated temperatures and concentrations. The hydroacid complex has displayed desired properties such as high solubility, low viscosity, excellent thermal stability and minimal reverse salt flux suitable for FO and MD operations. FO-MD desalination process was demonstrated with a highest seawater desalination flux of 6/32 LMH (FO/MD). This study may open up the prospective of employing the hydroacid complex as the draw solute in FO-MD hybrid systems for seawater /brackish desalination. © 2015 Elsevier B.V.

  12. MdMYB1 Regulates Anthocyanin and Malate Accumulation by Directly Facilitating Their Transport into Vacuoles in Apples.

    Science.gov (United States)

    Hu, Da-Gang; Sun, Cui-Hui; Ma, Qi-Jun; You, Chun-Xiang; Cheng, Lailiang; Hao, Yu-Jin

    2016-03-01

    Tonoplast transporters, including proton pumps and secondary transporters, are essential for plant cell function and for quality formation of fleshy fruits and ornamentals. Vacuolar transport of anthocyanins, malate, and other metabolites is directly or indirectly dependent on the H(+)-pumping activities of vacuolar H(+)-ATPase (VHA) and/or vacuolar H(+)-pyrophosphatase, but how these proton pumps are regulated in modulating vacuolar transport is largely unknown. Here, we report a transcription factor, MdMYB1, in apples that binds to the promoters of two genes encoding the B subunits of VHA, MdVHA-B1 and MdVHA-B2, to transcriptionally activate its expression, thereby enhancing VHA activity. A series of transgenic analyses in apples demonstrates that MdMYB1/10 controls cell pH and anthocyanin accumulation partially by regulating MdVHA-B1 and MdVHA-B2. Furthermore, several other direct target genes of MdMYB10 are identified, including MdVHA-E2, MdVHP1, MdMATE-LIKE1, and MdtDT, which are involved in H(+)-pumping or in the transport of anthocyanins and malates into vacuoles. Finally, we show that the mechanism by which MYB controls malate and anthocyanin accumulation in apples also operates in Arabidopsis (Arabidopsis thaliana). These findings provide novel insights into how MYB transcription factors directly modulate the vacuolar transport system in addition to anthocyanin biosynthesis, consequently controlling organ coloration and cell pH in plants.

  13. Unforced Revision in Processing Relative Clause Association Ambiguity in Japanese: Evidence Against Revision as Last Resort.

    Science.gov (United States)

    Yamada, Toshiyuki; Arai, Manabu; Hirose, Yuki

    2016-11-19

    The current study tackles a long standing question of whether comprehenders perform structural revision when it is not forced by grammar or not. Using an eye-tracking reading paradigm, we addressed this issue by making use of global structural ambiguity in Japanese. Our results show that comprehenders initially associate a relative clause with the first potential head noun and that they revise this analysis when the second noun is lexico-semantically possible as the relative clause head, but do not when it is impossible. The results are incompatible with the Revision as Last Resort hypothesis. Instead, they support the parsing with unforced revision that is immediately sensitive to lexical properties. We argue that our results cannot be accounted for by serial modular processing models but that they can be explained by ranked-parallel interactive processing models. Furthermore, we propose that head-finality is a key factor involved in the availability of unforced revision.

  14. 英语定语从句的翻译%Translation of English Attributive Clause

    Institute of Scientific and Technical Information of China (English)

    谢亚卓

    2015-01-01

    Attributive clause doesn’t exist in Chinese, but is widely used in English. It is also one of the major obstacles to translators in translation. The structures of the English attributive clauses are simple or complex, translators need to take the appropriate translation skills to translate them flexibly.%定语从句是汉语中没有而英语中却广泛使用的语言现象,也是译者翻译中的重大障碍之一。英语定语从句的结构有简有繁,翻译时需要采取恰当的翻译技巧来灵活处理。

  15. Enhancing Extraction of Drug-Drug Interaction from Literature Using Neutral Candidates, Negation, and Clause Dependency

    Science.gov (United States)

    Bokharaeian, Behrouz; Diaz, Alberto; Chitsaz, Hamidreza

    2016-01-01

    Motivation Supervised biomedical relation extraction plays an important role in biomedical natural language processing, endeavoring to obtain the relations between biomedical entities. Drug-drug interactions, which are investigated in the present paper, are notably among the critical biomedical relations. Thus far many methods have been developed with the aim of extracting DDI relations. However, unfortunately there has been a scarcity of comprehensive studies on the effects of negation, complex sentences, clause dependency, and neutral candidates in the course of DDI extraction from biomedical articles. Results Our study proposes clause dependency features and a number of features for identifying neutral candidates as well as negation cues and scopes. Furthermore, our experiments indicate that the proposed features significantly improve the performance of the relation extraction task combined with other kernel methods. We characterize the contribution of each category of features and finally conclude that neutral candidate features have the most prominent role among all of the three categories. PMID:27695078

  16. Free relative clauses: a new teaching approach for Italian learners of Latin and German

    Directory of Open Access Journals (Sweden)

    Sabrina Bertollo

    2013-05-01

    Full Text Available In this work we would like to present a new teaching proposal for free relative clauses, with a comparative perspective. The proposal is addressed to Italian learners of Latin and German with an advanced knowledge of the morpho-syntax of the three languages and tries to combine the theories proposed within the Generative Grammar framework with the needs which emerge from school teaching experiences. In the path we will develop, the students will be led to get familiar with this construction, first in the native language and then in German and Latin. Students will be stimulated to analyze the syntactic constraints, which are different in the three languages, so as to develop a new grammatical awareness and be in a position to correctly handle complex syntactic structures such as free relative clauses. This will be helpful to adequately cope with this specific construction, but it will also improve the overall skills.

  17. A Study of the Adsorption of Molecular Deposition Filming Flooding Agent MD-1 on Quartz Sand

    Institute of Scientific and Technical Information of China (English)

    GaoManglai; LiuYong; MengXiuxia; WangJianshe

    2004-01-01

    Molecular deposition filming flooding (MDFF) is a novel oil recovery technique based on the thermopositive monolayer electrostatic adsorption of the MDFF agent on different interfaces within reservoir systems. In this paper, the adsorption property of the MDFF agent, MD-I, on quartz sand has been studied through adsorption experiments at different pH and temperatures. Experimental data are also analyzed kinetically and thermodynamically. The results show that the adsorption of MD-I on quartz sand takes place mainly because of electrostatic interactions, which corresponds to adsorption that increases with pH. Kinetic analyses show that at a higher pH the activation energy for adsorption gets lower and, therefore, the adsorption becomes quicker for MD-1 on quartz sand. Thermodynamic analyses show that pH plays an important role in the adsorption of MD-1 on quartz sand. At a higher pH, more negative surface charges result in the increase of electrostatic interactions between MD-1 and quartz sand. Therefore, the saturated adsorption amount increases and more adsorption heat will be released.

  18. Chosen-Prefix Collisions for MD5 and Colliding X.509 Certificates for Different Identities

    Science.gov (United States)

    Stevens, Marc; Lenstra, Arjen; de Weger, Benne

    We present a novel, automated way to find differential paths for MD5. As an application we have shown how, at an approximate expected cost of 250 calls to the MD5 compression function, for any two chosen message prefixes P and P', suffixes S and S' can be constructed such that the concatenated values P||S and P'||S' collide under MD5. Although the practical attack potential of this construction of chosen-prefix collisions is limited, it is of greater concern than random collisions for MD5. To illustrate the practicality of our method, we constructed two MD5 based X.509 certificates with identical signatures but different public keys and different Distinguished Name fields, whereas our previous construction of colliding X.509 certificates required identical name fields. We speculate on other possibilities for abusing chosen-prefix collisions. More details than can be included here can be found on www.win.tue.nl/hashclash/ChosenPrefixCollisions/.

  19. Crystal twinning of human MD-2 recognizing endotoxin cores of lipopolysaccharide

    Energy Technology Data Exchange (ETDEWEB)

    Ohto, Umeharu; Satow, Yoshinori, E-mail: satowy@mol.f.u-tokyo.ac.jp [Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033 (Japan)

    2008-05-01

    Twinned crystals of humaan MD-2 are transformed into single crystals with cryoprotectant optimization. Twinning of crystals causes overlapping of two or more reciprocal lattice points, and hence structure amplitudes for a single crystalline domain are hardly obtained from X-ray diffraction intensities. MD-2 protein forms a stable complex with Toll-like receptor 4 and recognizes bacterial lipopolysaccharide (LPS). Excessive immune responses activated by LPS cause septic shocks. Saccharide-trimmed human MD-2 crystallizes in the tetragonal form with apparent Laue symmetry of 4/mmm, and diffraction intensities from these crystals indicate crystal twinning. The crystal consists of two different domains, A and B. The c{sub A} axis of domain A coincides with the c{sub B} axis of domain B with a smaller lattice, and the a{sub A} axis corresponds to the (a{sub B} + b{sub B}) axis. This twinning severely imposes difficulty in structure determination. Through optimization of cryoprotectant, domain A was thoroughly transformed into domain B. The crystal containing only domain B is in space group P4{sub 1}2{sub 1}2 with one MD-2 molecule in the asymmetric unit. The structure of this form of MD-2 as well as its complex with antiendotoxic lipid IVa was successfully determined using the multiple isomorphous replacement method.

  20. A constraint-based bottom-up counterpart to definite clause grammars

    DEFF Research Database (Denmark)

    Christiansen, Henning

    2004-01-01

    A new grammar formalism, CHR Grammars (CHRG), is proposed that provides a constraint-solving approach to language analysis, built on top of the programming language of Constraint Handling Rules in the same way as Definite Clause Grammars (DCG) on Prolog. CHRG works bottom-up and adds the following......, integrity constraints, operators a la assumption grammars, and to incorporate other constraint solvers. (iv)~Context-sensitive rules that apply for disambiguation, coordination in natural language and tagger-like rules....

  1. Conversion of Claus plants of Kurkuk-Iraq to produce hydrogen and sulfur

    Energy Technology Data Exchange (ETDEWEB)

    Naman, S.A.; Veziroglu, A. [Duhok Univ., Duhok City (Iraq). Dept. of Chemistry; International Association for Hydrogen Energy, Miami, FL (United States)

    2009-07-01

    Two Claus plants in Kirkuk, Iraq, convert hydrogen sulfide to elemental sulfur at a capacity of 2,200 tons/day. One of the plants is working at a capacity of only 400 tons/day with an old Claus process. The other uses a modified Claus sulfur recovery process with a capacity of 1800 tons/day. Both of the plants operate with low efficiency due to lack of maintenance. As such, the agricultural area surrounding Kirkuk is highly polluted. This paper described 2 pilot desulphurization plants that have been constructed inside the modified Claus plant. The first pilot plant is based on the flow system tube furnace reactor containing mixed titanium oxide/sulfide with a cold trap for sulfur separation and a bath of 30 per cent dithanolamine to separate and recycle hydrogen sulphide (H{sub 2}S) from hydrogen. The second pilot plant consists of a thermal diffusion ceramic rod inside a silica column containing zeolite 5A as a catalyst. This pilot plant also consists of a trap for continuous separation of sulfur and a system for separation of hydrogen from unreacted H{sub 2}S to recycle. The efficiency of conversion of H{sub 2}S to hydrogen and sulfur has been optimized as a function of catalyst type and mixture, temperature of furnace, flow rate of gas and reactor materials. The pilot plants were suitable with cadmium chalcogens catalysts to produce hydrogen, methane, ethane and sulphur, but with lower efficiency than H{sub 2}S decomposition only. The goal for the second pilot plant was to supply the heat using a solar energy concentrator instead of electricity. It was concluded that a hydrogen production plant in this part of Iraq will save a large area from polluted sulfur gas. The pilot plants can produce about 140 tons of hydrogen gas per day from these waste gases.

  2. [The physician's conscience, conscience clauses, and religious belief: A Catholic perspective].

    Science.gov (United States)

    Pellegrino, Edmund D

    2014-01-01

    This Essay explores how physicians may handle conflicts or conscience facing Roman Catholic Health practitioners regarding "human life" issues, especially through conscience clauses. In five parts, the author examines "first, why conscientious objection is so important in our day; second, the moral grounding for freedom in the exercise of conscience; third, the components of the physician's conscience; fourth, specific conflicts of conscience for Catholic physicians and institutions; and fifth, competing models of conflict resolution".

  3. A technique for solving constraint satisfaction problems using Prolog's definite clause grammars

    Science.gov (United States)

    Nachtsheim, Philip R.

    1988-01-01

    A new technique for solving constraint satisfaction problems using Prolog's definite clause grammars is presented. It exploits the fact that the grammar rule notation can be viewed as a state exchange notation. The novel feature of the technique is that it can perform informed as well as blind search. It provides the Prolog programmer with a new technique for application to a wide range of design, scheduling, and planning problems.

  4. Understanding VSIDS Branching Heuristics in Conflict-Driven Clause-Learning SAT Solvers

    OpenAIRE

    Liang, Jia Hui; Ganesh, Vijay; Zulkoski, Ed; Zaman, Atulan; Czarnecki, Krzysztof

    2015-01-01

    Conflict-Driven Clause-Learning SAT solvers crucially depend on the Variable State Independent Decaying Sum (VSIDS) branching heuristic for their performance. Although VSIDS was proposed nearly fifteen years ago, and many other branching heuristics for SAT solving have since been proposed, VSIDS remains one of the most effective branching heuristics. In this paper, we advance our understanding of VSIDS by answering the following key questions. The first question we pose is "what is special ab...

  5. THE ROLE OF THE GRAMMAR ON PORTUGUESE TEXTBOOKS: A LOOK ON TEACHING OF RELATIVE CLAUSE

    OpenAIRE

    Câmara, Aliana Lopes; Instituto de Biociência, Letras e Ciências Exatas; Abreu-Tardelli, Lília Santos; Instituto de Biociências, Letras e Ciências Exatas

    2014-01-01

    This paper studies how the textbooks of Portuguese Language of Secondary School, approved by the Programa Nacional do Livro Didático-2014, approach the teaching of grammar, in particular as regards the treatment of the relative subordinate clause. For this, first we start with the comparison between the proposals manuals for teaching grammar and what was accomplished in the student book. Furthermore, we propose here an interface between the results of the analysis of textbooks and functional ...

  6. Reaction Mechanism for m- Xylene Oxidation in the Claus Process by Sulfur Dioxide

    KAUST Repository

    Sinha, Sourab

    2015-09-24

    In the Claus process, the presence of aromatic contaminants such benzene, toluene, and xylenes (BTX), in the H2S feed stream has a detrimental effect on catalytic reactors, where BTX form soot particles and clog and deactivate the catalysts. Among BTX, xylenes are proven to be most damaging contaminant for catalysts. BTX oxidation in the Claus furnace, before they enter catalyst beds, provides a solution to this problem. A reaction kinetics study on m-xylene oxidation by SO2, an oxidant present in Claus furnace, is presented. The density functional theory is used to study the formation of m-xylene radicals (3-methylbenzyl, 2,6-dimethylphenyl, 2,4-dimethylphenyl, and 3,5-dimethylphenyl) through H-abstraction and their oxidation by SO2. The mechanism begins with SO2 addition on the radicals through an O-atom rather than the S-atom with the release of 180.0-183.1 kJ/mol of reaction energies. This exothermic reaction involves energy barriers in the range 3.9-5.2 kJ/mol for several m-xylene radicals. Thereafter, O-S bond scission takes place to release SO, and the O-atom remaining on aromatics leads to CO formation. Among four m-xylene radicals, the resonantly stabilized 3-methylbenzyl exhibited the lowest SO2 addition and SO elimination rates. The reaction rate constants are provided to facilitate Claus process simulations to find conditions suitable for BTX oxidation. © 2015 American Chemical Society.

  7. Implementation of MD5 Fast Crack Based on GPU Cluster%基于GPU集群实现MD5的快速破解

    Institute of Scientific and Technical Information of China (English)

    杨胜斌

    2013-01-01

    从单个GPU异构并行系统来看,其性能还是比较有限,文章阐述了基于GPU集群的CUDA架构实现过程,详细分析基于GPU集群进行MD5快速破解的编译过程,并对破解程序进行测试研究,对其运行结果进行测试和分析,探讨搭建GPU高性能计算集群及其进行MD5算法的快速破解的过程.

  8. The Production of Turkish Relative Clauses in Second Language Acquisition: Overcoming Student Difficulties

    Directory of Open Access Journals (Sweden)

    Anjel Toczu

    2010-01-01

    Full Text Available This study focuses on teaching relative clauses (R.Cs in Turkish, a left-branching language, and discusses the relative difficulty of producing RCs in Turkish by English-speaking learners by investigating whether the production of subject relative clauses in Turkish is easier than that of the object relative clauses. It also offers suggestions as to how to help learners overcome these difficulties. Turkish and English belong to two different language families, Altaic and Inda-European respectively. This study lends further insight that Turkish does not have RCs similar to those found in Inda-European languages. Instead, in Turkish RCs comprise nominalized verbs and participles. The characteristics of Turkish are also explained such as its word order, agglutinating morphology, vowel and consonant harmony rules as well as case markers indicating grammatical relations between sentence constituents, which shed light to our understanding of RCs in Turkish. Data was collected through written and oral tasks from students enrolled in a military intensive Turkish language training program in the United States. Moreover, their performance was studied through classroom observations and one-on-one speaking activities.

  9. FOSTERING STUDENTS’ CLAUSE AWARENESS ON READING: The Exploration on Transitivity System

    Directory of Open Access Journals (Sweden)

    Muchamad Adam Basori

    2016-07-01

    Full Text Available The opportunity to help students easily read English texts by observing content of the texts, which are construed in students’ world experience into limited set of processes type: material, mental, relational, behavioural, verbal and existential has confirmed the necessity of combating misunderstanding clause meanings (process, participant, circumstance. The notion of reading a text is manifested in the processes from a step-by-step lexico-grammatical analysis to contextual description, which are realised as a configuration of transitivity functions which represent the process, the participant situation, the attributes assigned to participant, and the circumstances associated with the process. These are typical patterns of lexico-grammatical realization. This study will examine the transitivity analysis, which provides the recognition of clause awareness on reading English texts. The implication of clause awareness on reading English texts based on the processes is to describe certain feeling, thought, and perception (perceiving through five senses and creating an ordered technical vocabulary and way of classifying the world.

  10. Subject relative clauses are not universally easier to process: Evidence from Basque.

    Science.gov (United States)

    Carreiras, Manuel; Duñabeitia, Jon Andoni; Vergara, Marta; de la Cruz-Pavía, Irene; Laka, Itziar

    2010-04-01

    Studies from many languages consistently report that subject relative clauses (SR) are easier to process than object relatives (OR). However, Hsiao and Gibson (2003) report an OR preference for Chinese, a finding that has been contested. Here we report faster OR versus SR processing in Basque, an ergative, head-final language with pre-nominal relative clauses. A self-paced reading task was used in Experiments 1 and 2, while ERPs were recorded in Experiment 3. We used relative clauses that were ambiguous between an object or subject-gap interpretation and disambiguated later in the sentence. The results of Experiments 1 and 2 showed that SR took longer to read than OR in the critical disambiguating region. In addition, Experiment 3 showed that SR produced larger amplitudes than OR in the P600 window immediately after reading the critical disambiguating word. Our results suggest that SR are not universally easier to process. They cast doubts on universal hypotheses and suggest that processing complexity may depend on language-specific aspects of grammar.

  11. Complex Clause Syntax in the Italian Classroom – the Learners Between Transfer and Interference

    Directory of Open Access Journals (Sweden)

    Darja Mertelj

    2013-12-01

    Full Text Available When teaching Italian as a foreign language, learners’ insecurities about using conjunctions and tenses in subordinate clauses can be noticed very early. Temporality, relative temporality and modality are signalled by Italian verb forms which function in a largely different (or apparently similar way in comparison to Slovene. If ‘true’ similarities can be exploited in the process of teaching/learning by means of a positive transfer, apparent ‘similarities’ and ‘differences’ between the two language systems should, on the other hand, be clarified to avoid negative transfer (interference. During the whole learning process language awareness should be developed, also through contrastive insights into the linguistic systems concerned. Taking as a starting point a text suitable for level B1, some problematic points are presented, for which a series of tasks can be suggested with the aim of helping the learner master complex clause syntax and develop language awareness. Key words: Italian, foreign/second language, complex clause, syntax, transfer, language awareness

  12. 基于MD5与Base64的混合加密算法%MD5-Base64 based hybrid encryption algorithm

    Institute of Scientific and Technical Information of China (English)

    罗江华

    2012-01-01

    介绍了一种基于MD5和Base64的混合加密算法,首先将明文MD5加密得到32位16进制密文,再将32位密文拆分成16个2位16进制数组,并转换成对应的二进制数,最后将16个二进制数组连接成一个128位的2进制数,采用Base64加密原理进行加密.该算法可以避免查询MD5散列值字典获取用户明文密码,更加有效地保证了用户的密码安全,最后给出了算法的PHP实现.%A MD5-Base64 baaed hybrid encryption algorithm was introduced, which encrypted plain text to 32-bit hexadecimal cipher text by MDS encryption, then split this 32-bit hexadecimal into 16 parts, and transformed them into binary Cor each part to join them together as a 128-bit binary, finally, encrypted the 128-bit binary array by using Base64 algorithm. This algorithm can avoid getting user's clear text password by querying MDS hash database, and protect user's password more effectively. This algorithm was described by PHP script language at the fourth section.

  13. 基于CUDA架构的MD5并行分析算法研究%Research of MD5 Parallel Algorithm Based on CUDA

    Institute of Scientific and Technical Information of China (English)

    张伟; 陈田国; 陶志荣

    2009-01-01

    在介绍了CUDA(统一计算设备架构)架构的基础上,给出了一种CUDA架构上进行MD5摘要分析的并行算法.算法有效利用了GPU的并行性和CUDA架构的优势实现了较快的运算速度,测试结果显示优于CPU的算法.

  14. 改造MD5让破解程序见鬼去

    Institute of Scientific and Technical Information of China (English)

    安美洪

    2005-01-01

    也许提到MD5时大家都很熟,但你真的了解它吗?虽然一般人是不用这样去寻根问底的,要用的时候直接去下载别人已编好的程序用就得了,但象我这样的好事者总想抓住点什么另类的东西——你有没有想过自己修改MD5,让网上漫天飞的MD5破解工具变得一无是处?要是有兴趣就往下看吧!

  15. 在飞速网用MD5值搜索PE系统

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    如果你要测试某PE系统.可是很多专门下载网站的资源链接都已经失效,幸好对于操作系统这类资源.很多网站都提供下载资源的MD5值。现在只要记下失效链接网站提供的资源MD5值,然后在地址栏输入http://www.raylile.com/zh—cn/files/6FA887054AB3EE91A5F542227FDC7493(“files/”后面的内容即为要搜索文件的MD5值).回车后即可跳转到该资源的下载链接中。

  16. Development and reactivity tests of Ce-Zr-based Claus catalysts for coal gas cleanup

    Energy Technology Data Exchange (ETDEWEB)

    No-Kuk Park; Dong Cheul Han; Gi Bo Han; Si Ok Ryu; Tae Jin Lee; Ki Jun Yoon [Yeungnam University, Gyeongbuk (Republic of Korea). National Research Laboratory, School of Chemical Engineering and Technology

    2007-09-15

    Claus reaction (2H{sub 2}S + SO{sub 2} {leftrightarrow} 3/nS{sub n} + 2H{sub 2}O) was used to clean the gasified coal gas and the reactivity of several metal oxide-based catalysts on Claus reaction was investigated at various operating conditions. In order to convert H{sub 2}S contained in the gasified coal gas to elemental sulfur during Claus reaction, the catalysts having the high activity under the highly reducing condition with the moisture should be developed. CeO{sub 2}, ZrO{sub 2}, and Ce{sub 1-x}Zr{sub x}O{sub 2} catalysts were prepared for Claus reaction and their reactivity changes due to the existence of the reducing gases and H{sub 2}O in the fuel gas was investigated in this study. The Ce-based catalysts shows that their activity was deteriorated by the reduction of the catalyst due to the reducing gases at higher than 220{sup o}C. Meanwhile, the effect of the reducing gases on the catalytic activity was not considerable at low temperature. The activities of all three catalysts were degraded on the condition that the moisture existed in the test gas. Specifically, the Ce-based catalysts were remarkably deactivated by their sulfation. The Ce-Zr-based catalyst had a high catalytic activity when the reducing gases and the moisture co-existed in the simulated fuel gas. The deactivation of the Ce-Zr-based catalyst was not observed in this study. The lattice oxygen of the Ce-based catalyst was used for the oxidation of H{sub 2}S and the lattice oxygen vacancy on the catalyst was contributed to the reduction of SO{sub 2}. ZrO{sub 2} added to the Ce-Zr-based catalyst improved the redox properties of the catalyst in Claus reaction by increasing the mobility of the lattice oxygen of CeO{sub 2}. 21 refs., 14 figs.

  17. MD5解密器速度加强版V2.2

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    MD5密码的破解软件很多.今天介绍的这款MD5解密器速度加强版是原作者在此软件V2.0的基础上去除了影响速度的功能.并对加密算法进行了修改的结果.速度比同类解密器快了非常多。

  18. Computation of shear viscosity of colloidal suspensions by SRD-MD

    Energy Technology Data Exchange (ETDEWEB)

    Laganapan, A. M. K.; Videcoq, A., E-mail: arnaud.videcoq@unilim.fr; Bienia, M. [SPCTS, UMR 7315, ENSCI, CNRS, Centre Européen de la Céramique, 12 rue Atlantis, 87068 Limoges Cedex (France); Ala-Nissila, T. [COMP CoE at the Department of Applied Physics, Aalto University School of Science, P.O. Box 11000, FIN-00076 Aalto, Espoo (Finland); Department of Physics, Brown University, Providence, Rhode Island 02912-1843 (United States); Bochicchio, D.; Ferrando, R. [Dipartimento di Fisica and CNR-IMEM, via Dodecaneso 33, Genova I-16146 (Italy)

    2015-04-14

    The behaviour of sheared colloidal suspensions with full hydrodynamic interactions (HIs) is numerically studied. To this end, we use the hybrid stochastic rotation dynamics-molecular dynamics (SRD-MD) method. The shear viscosity of colloidal suspensions is computed for different volume fractions, both for dilute and concentrated cases. We verify that HIs help in the collisions and the streaming of colloidal particles, thereby increasing the overall shear viscosity of the suspension. Our results show a good agreement with known experimental, theoretical, and numerical studies. This work demonstrates the ability of SRD-MD to successfully simulate transport coefficients that require correct modelling of HIs.

  19. LHC Transvers Profile Monitors studies (MD on May 6th, 2011)

    CERN Document Server

    Bravin, E; Dehning, B; Emery, J; Lefevre, T; Gras, JJ; Jeff, A; Rabiller, A; Roncarolo, F; Sapinski, M; Kain, V; Pojer, M; Bartosik, H; Salvant, B

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 6-May-2011 (from 2 to 10 a.m.), dedicated to study Wire Scanners (WS), Synchrotron Radiation Monitors (BSRT) and Beam Gas Ionization Monitors (BGI). The MD aimed at performing different studies on the individual monitors as well as at cross calibrating them with beams composed of bunches with different transverse emittances in stable conditions. At the same time, it was possible to perform calibration studies with the Abort Gap Monitor (AGM) and Longitudinal Density Monitor (LDM) that share the extracted light with the BSRT.

  20. The topology of foliations formed by the generic K-orbits of a subclass of the indecomposable MD5-groups

    Institute of Scientific and Technical Information of China (English)

    VU; Le; Anh; HOA; Duong; Quang

    2009-01-01

    The paper is a continuation of the authors’ works in 2007. We consider the MD5-foliations associated to connected and simply connected MD5-groups such that their Lie algebras have 4-dimensional commutative derived ideals. In this study, we give a topological classification of all considered MD5-foliations. A description of these foliations by certain fibrations or suitable actions of R2 and the Connes’ C*-algebras of the foliations which come from fibrations are also given.

  1. MD-2 Residues Tyrosine 42, Arginine 69, Aspartic Acid 122, and Leucine 125 Provide Species Specificity for Lipid IVA*

    Science.gov (United States)

    Meng, Jianmin; Drolet, Joshua R.; Monks, Brian G.; Golenbock, Douglas T.

    2010-01-01

    Lipopolysaccharide (LPS) activates the innate immune response through the Toll-like receptor 4 (TLR4)·MD-2 complex. A synthetic lipid A precursor, lipid IVA, induces an innate immune response in mice but not in humans. Both TLR4 and MD-2 are required for the agonist activity of lipid IVA in mice, with TLR4 interacting through specific surface charges at the dimerization interface. In this study, we used site-directed mutagenesis to identify the MD-2 residues that determine lipid IVA species specificity. A single mutation of murine MD-2 at the hydrophobic pocket entrance, E122K, substantially reduced the response to lipid IVA. Combining the murine MD-2 E122K with the murine TLR4 K367E/S386K/R434Q mutations completely abolished the response to lipid IVA, effectively converting the murine cellular response to a human-like response. In human cells, however, simultaneous mutations of K122E, K125L, Y41F, and R69G on human MD-2 were required to promote a response to lipid IVA. Combining the human MD-2 quadruple mutations with the human TLR4 E369K/Q436R mutations completely converted the human MD-2/human TLR4 receptor to a murine-like receptor. Because MD-2 residues 122 and 125 reside at the dimerization interface near the pocket entrance, surface charge differences here directly affect receptor dimerization. In comparison, residues 42 and 69 reside at the MD-2/TLR4 interaction surface opposite the dimerization interface. Surface charge differences there likely affect the binding angle and/or rigidity between MD-2 and TLR4, exerting an indirect influence on receptor dimerization and activation. Thus, surface charge differences at the two MD-2/TLR4 interfaces determine the species-specific activation of lipid IVA. PMID:20592019

  2. The topology of foliations formed by the generic K-orbits of a subclass of the indecomposable MD5-groups

    Institute of Scientific and Technical Information of China (English)

    VU Le Anh; HOA Duong Quang

    2009-01-01

    The paper is a continuation of the authors' works in 2007. We consider the MD5-foliations associated to connected and simply connected MD5-groups such that their Lie algebras have 4-dimensional commutative derived ideals. In this study, we give a topological classification of all considered MD5-foliations. A description of these foliations by certain fibrations or suitable actions of R2 and the Connes' C*-algebras of the foliations which come from fibrations are also given.

  3. The effectiveness of take-or-pay clauses under the Brazilian courts; A eficacia das clausulas de 'take-or-pay' nos tribunais brasileiros

    Energy Technology Data Exchange (ETDEWEB)

    Goncalves, Bruno A.; Travassos, Cristiano H. [Tess Advogados, Sao Paulo, SP (Brazil)

    2008-07-01

    The international energy industry, where the sale of their commodities (oil, natural gas, biofuels and its derivatives), typically uses in its long-term contracts clauses take-or-pay. However, questioning about the Brazilian judicial effectiveness of such clauses appears each day. This paper aims to establish a rationale clause of take-or-pay; have terms and typical conditions of one clause of take-or-pay; discuss the existing national law on the subject; list the main questions arising from the applicability of the terms of take-or-pay, and the potential solutions to the current scenario.

  4. MD5算法及在用户口令加密应用中的改进

    Institute of Scientific and Technical Information of China (English)

    高洪波; 马素萍

    2010-01-01

    MD5是一种非常优秀的加密算法,曾被大量公司和个人广泛使用。但随着科学技术的发展,MD5牢不可破的神话逐渐破灭。基于此,在分析MD5加密算法及其弱点的前提下,探讨了MD5的改进算法。

  5. The MdTFL1 gene of apple (Malus x domestica Borkh.) reduces vegetative growth and generation time.

    Science.gov (United States)

    Flachowsky, Henryk; Szankowski, Iris; Waidmann, Sascha; Peil, Andreas; Tränkner, Conny; Hanke, Magda-Viola

    2012-10-01

    TFL1 is known as a floral repressor in Arabidopsis thaliana (L.) Heynh. In apple there are two TFL1 homologs, MdTFL1-1 and MdTFL1-2. The MdTFL1-1 gene was silenced in transgenic clones expressing a hairpin gene construct of a 323 bp fragment of MdTFL1-1. The hairpin gene construct was transferred to three different apple genotypes. Of 22 transgenic clones, 21 showed a significant reduction in MdTFL1-1 mRNA expression. Precocious flowering was obtained for 20 clones, which flowered already during in vitro cultivation. Nineteen clones could successfully be transferred to the greenhouse where 18 of them flowered within a few weeks followed by the death or at least a strongly inhibited vegetative growth of the plant. Most of the transgenic flowers developed abnormally. Results obtained on greenhouse-grown plants of the transgenic clones and transgenic seedlings clearly demonstrated the major role of MdTFL1 genes in maintaining the vegetative growth as prerequisite for a perennial lifecycle. It was shown that MdTFL1 dsRNAi promotes a life history similar to annual plants. Preliminary results obtained from grafting experiments with non-transgenic scions grafted onto MdTFL1 dsRNAi transgenic rootstocks indicated that the flower-inducing signal obtained after silencing of MdTFL1 genes seems not to be graft-transmissible.

  6. CORROSION INHIBITION ACTIONS OF BIS-BENZOTRIAZOLE MANNICH ALKALI COMPOUNDS FOR COPPERIN 5%NAHCO3 SOLUTION%双苯并三唑Mannich碱在5%NaHCO3溶液中对Cu的缓蚀作用

    Institute of Scientific and Technical Information of China (English)

    左书瑞; 刘瑞泉

    2011-01-01

    以苯并三唑(BTA)为母体合成了两种双苯并三唑Mannich碱1,2-双([1,2,3]苯并三唑)-1,2-二苯基氨基乙烷(BBTAP)和1,2-双([1,2,3]苯并三唑)-1,2-二甲基氨基乙烷(BBTAM).采用静态失重法、极化曲线和电化学阻抗谱(EIS)研究了BBTAP、BBTAM和BTA在5 mass%NaHCO水溶液中的缓蚀性能和吸附行为.结果表明:在较高温度下,三种化合物在5%NaHCO溶液中对Cu均有较好的缓蚀作用.与BTA相比,BBTAP和BBTAM具有用量少,缓蚀效率高的特点.三种化合物在铜表面上的吸附过程均为放热过程,在铜表面上的吸附行为服从Langmuir吸附等温式,属于物理-化学混合吸附.%Two bis-benzotriazole Mannich alkali compounds, 1,2-di(1H-benzo[d][1,2,3] triazol-1-yl)-N1,N2- diphenylethane-1,2-diamine (BBTAP) and 1,2-di(1H-benzo[d][1,2,3] triazol-1-yl)-N1, N2-dimethylethane-1, 2diamine (BBTAM), were synthesized using benzotriazole (BTA) as matrix. The inhibition actions and adsorption behaviors of BBTAP, BBTAM and BTA on copper in aqueous NaHCO3 (mass fraction 5%) solution were investigated by means of mass loss and electrochemical techniques including polarization curve and electrochemical impedance spectroscopy (EIS). The results showed that BBTAP, BBTAM and BTA exhibited good inhibition effect for copper in 5% NaHCO3 solution at higher temperature and BBTAP, BBTAM had better corrosion inhibition efficiency than that of BTA. The results of experiment revealed that the adsorption processes were exothermic reaction and belonged to physical and chemical mix absorption, the adsorption behaviors followed Langmuir isotherm.

  7. Study on the Synthesis and Performance of a Mannich Based Acidification Corrosion Inhibitor%曼尼希酸化缓蚀剂H-402的合成及其缓蚀性能研究

    Institute of Scientific and Technical Information of China (English)

    张勇; 陆原; 张颖; 胡廷; 赵璐

    2013-01-01

    A oilfield acidification corrosion inhibitor was synthesized by Mannich reaction of secondary amine, acetophenone and formaldehyde. The effect of the synthetic technology, including molar ratio of reactant, reaction temperature and reaction time, on the inhibition performance of the inhibitor was evaluated by coupon corrosion tests. In addition, the inhibition mechanism of the inhibitor was investigated by electrochemical test and scanning electronic microscope observation. The results showed that the inhibitor exhibited the best inhibition efficiency when the molar ratio of primary amine, acetophenone and formaldehyde was 1:2:5 and the reaction were maintained at 80℃ for 10 h. After compounded with polyether and propargyl alcohol, the inhibitor could reach the first-class level at the dosage of 0.5%. The corrosion inhibitor was assigned as a mixed inhibitor mainly which inhibited the anode process through electrochemistry method. The scanning electronic microscope observation indicated that the corrosion forms of steels were improved significantly after adding 0.5% corrosion inhibitor.%本文采用仲胺、苯乙酮、甲醛为原料,通过曼尼希缩合反应,合成了一种油田酸化缓蚀剂H-402,研究了合成工艺对产物性能的影响及缓蚀机理.结果表明:在仲胺/苯乙酮/甲醛摩尔比1∶2∶5、反应温度80℃、反应时间10h条件下,所合成的H-402的缓蚀效果最佳.该缓蚀剂与聚醚、丙炔醇等具有增效作用,加剂量为0.5%时达到缓蚀剂一级水平.该缓蚀剂为抑制阳极过程为主的混合型缓蚀剂.扫描电镜显示,加入0.5%H-402后,Q235挂片表面的腐蚀形态得到极大的改善.

  8. 78 FR 19012 - Pawan Kumar Jain, M.D.; Decision And Order

    Science.gov (United States)

    2013-03-28

    ...., 65 FR 5,661 (DEA 2000); Jesus R. Juarez, M.D., 62 FR 14,945 (DEA 1997). Accordingly, both the plain... to practice medicine or handle controlled substances in the State of New Mexico'' and Respondent's... alleged that the New Mexico State Medical Board took action against the Respondent on June 28, 2012. ....

  9. Vienna-PTM web server: a toolkit for MD simulations of protein post-translational modifications

    Science.gov (United States)

    Margreitter, Christian; Petrov, Drazen; Zagrovic, Bojan

    2013-01-01

    Post-translational modifications (PTMs) play a key role in numerous cellular processes by directly affecting structure, dynamics and interaction networks of target proteins. Despite their importance, our understanding of protein PTMs at the atomistic level is still largely incomplete. Molecular dynamics (MD) simulations, which provide high-resolution insight into biomolecular function and underlying mechanisms, are in principle ideally suited to tackle this problem. However, because of the challenges associated with the development of novel MD parameters and a general lack of suitable computational tools for incorporating PTMs in target protein structures, MD simulations of post-translationally modified proteins have historically lagged significantly behind the studies of unmodified proteins. Here, we present Vienna-PTM web server (http://vienna-ptm.univie.ac.at), a platform for automated introduction of PTMs of choice to protein 3D structures (PDB files) in a user-friendly visual environment. With 256 different enzymatic and non-enzymatic PTMs available, the server performs geometrically realistic introduction of modifications at sites of interests, as well as subsequent energy minimization. Finally, the server makes available force field parameters and input files needed to run MD simulations of modified proteins within the framework of the widely used GROMOS 54A7 and 45A3 force fields and GROMACS simulation package. PMID:23703210

  10. 75 FR 8749 - Dwayne LaFrantz Wilson, M.D.; Revocation of Registration

    Science.gov (United States)

    2010-02-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Dwayne LaFrantz Wilson, M.D.; Revocation of Registration On October 22, 2008, the... attempted to serve a property owner with notice of a tax sale by certified mail which was returned...

  11. MD-SeeGH: a platform for integrative analysis of multi-dimensional genomic data

    Directory of Open Access Journals (Sweden)

    Ng Raymond T

    2008-05-01

    Full Text Available Abstract Background Recent advances in global genomic profiling methodologies have enabled multi-dimensional characterization of biological systems. Complete analysis of these genomic profiles require an in depth look at parallel profiles of segmental DNA copy number status, DNA methylation state, single nucleotide polymorphisms, as well as gene expression profiles. Due to the differences in data types it is difficult to conduct parallel analysis of multiple datasets from diverse platforms. Results To address this issue, we have developed an integrative genomic analysis platform MD-SeeGH, a software tool that allows users to rapidly and directly analyze genomic datasets spanning multiple genomic experiments. With MD-SeeGH, users have the flexibility to easily update datasets in accordance with new genomic builds, make a quality assessment of data using the filtering features, and identify genetic alterations within single or across multiple experiments. Multiple sample analysis in MD-SeeGH allows users to compare profiles from many experiments alongside tracks containing detailed localized gene information, microRNA, CpG islands, and copy number variations. Conclusion MD-SeeGH is a new platform for the integrative analysis of diverse microarray data, facilitating multiple profile analyses and group comparisons.

  12. Short Chosen-Prefix Collisions for MD5 and the Creation of a Rogue CA Certificate

    NARCIS (Netherlands)

    Stevens, M.M.J.; Sotirov, A.; Appelbaum, J.; Lenstra, A.K.; Molnar, D.; Osvik, D.A.; Weger, B. de

    2009-01-01

    We present a refined chosen-prefix collision construction for MD5 that allowed creation of a rogue Certification Authority (CA) certificate, based on a collision with a regular end-user website certificate provided by a commercial CA. Compared to the previous construction from Eurocrypt 2007, this p

  13. PHYSICAL PROPERTIES OF NEAR-EARTH ASTEROID 2011 MD

    Energy Technology Data Exchange (ETDEWEB)

    Mommert, M.; Trilling, D. E. [Department of Physics and Astronomy, Northern Arizona University, P.O. Box 6010, Flagstaff, AZ 86011 (United States); Farnocchia, D.; Chesley, S. R.; Chodas, P. W. [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); Hora, J. L.; Smith, H. A.; Fazio, G. G. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, MS 65, Cambridge, MA 02138-1516 (United States); Mueller, M. [SRON Netherlands Institute for Space Research, Postbus 800, 9700-AV Groningen (Netherlands); Harris, A. W. [DLR Institute of Planetary Research, Rutherfordstrasse 2, D-12489 Berlin (Germany)

    2014-07-01

    We report on observations of near-Earth asteroid 2011 MD with the Spitzer Space Telescope. We have spent 19.9 hr of observing time with channel 2 (4.5 μm) of the Infrared Array Camera and detected the target within the 2σ positional uncertainty ellipse. Using an asteroid thermophysical model and a model of nongravitational forces acting upon the object, we constrain the physical properties of 2011 MD, based on the measured flux density and available astrometry data. We estimate 2011 MD to be (6{sub −2}{sup +4}) m in diameter with a geometric albedo of 0.3{sub −0.2}{sup +0.4} (uncertainties are 1σ). We find the asteroid's most probable bulk density to be (1.1{sub −0.5}{sup +0.7}) g cm{sup –3}, which implies a total mass of (50-350) t and a macroporosity of ≥65%, assuming a material bulk density typical of non-primitive meteorite materials. A high degree of macroporosity suggests that 2011 MD is a rubble-pile asteroid, the rotation of which is more likely to be retrograde than prograde.

  14. 77 FR 34998 - Darryl J. Mohr, M.D.; Affirmance of Immediate Suspension Order

    Science.gov (United States)

    2012-06-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Darryl J. Mohr, M.D.; Affirmance of Immediate Suspension Order On January 20, 2011... a doctor shopper and then all of a sudden no pharmacy is gonna give you any medication.''...

  15. Novel plasmid conferring kanamycin and tetracycline resistance in turkey-derived Campylobacter jejuni strain 11601MD

    Science.gov (United States)

    In Campylobacter spp., resistance to the antibiotics kanamycin and tetracycline is frequently associated with plasmid-borne genes. However, relatively few plasmids of Campylobacter jejuni have been fully characterized to date. A novel plasmid (p11601MD; 44,095 bp.) harboring tet(O) was identified in...

  16. 33 CFR 110.70 - Chesapeake and Delaware Canal, easterly of Courthouse Point, Md.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Chesapeake and Delaware Canal, easterly of Courthouse Point, Md. 110.70 Section 110.70 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.70 Chesapeake and Delaware Canal, easterly of...

  17. Data of evolutionary structure change: 1F3MD-1WBSA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1F3MD-1WBSA 1F3M 1WBS D A SDEEILEKLRSIVSVGD----------PKKKYTRFEKIG...231 PRO CA 199 1WBS A 1WBS... CA 366 THR CA 406 PRO CA 404 GLU CA 328 1WBS... A 1WBSA KLILRLV...> 2 1WBS A 1WBSA

  18. 78 FR 19009 - Gary Alfred Shearer, M.D.; Decision And Order

    Science.gov (United States)

    2013-03-28

    ... apply the principle of law that holds such a motion may be granted in an administrative proceeding if no... Enforcement Administration Gary Alfred Shearer, M.D.; Decision And Order On February 4, 2013, Administrative... registrant cannot collaterally attack the result of a state criminal or administrative proceeding in...

  19. The draft genome of MD-2 pineapple using hybrid error correction of long reads

    Science.gov (United States)

    Redwan, Raimi M.; Saidin, Akzam; Kumar, S. Vijay

    2016-01-01

    The introduction of the elite pineapple variety, MD-2, has caused a significant market shift in the pineapple industry. Better productivity, overall increased in fruit quality and taste, resilience to chilled storage and resistance to internal browning are among the key advantages of the MD-2 as compared with its previous predecessor, the Smooth Cayenne. Here, we present the genome sequence of the MD-2 pineapple (Ananas comosus (L.) Merr.) by using the hybrid sequencing technology from two highly reputable platforms, i.e. the PacBio long sequencing reads and the accurate Illumina short reads. Our draft genome achieved 99.6% genome coverage with 27,017 predicted protein-coding genes while 45.21% of the genome was identified as repetitive elements. Furthermore, differential expression of ripening RNASeq library of pineapple fruits revealed ethylene-related transcripts, believed to be involved in regulating the process of non-climacteric pineapple fruit ripening. The MD-2 pineapple draft genome serves as an example of how a complex heterozygous genome is amenable to whole genome sequencing by using a hybrid technology that is both economical and accurate. The genome will make genomic applications more feasible as a medium to understand complex biological processes specific to pineapple. PMID:27374615

  20. 75 FR 27430 - Special Local Regulations for Marine Events; Patapsco River, Northwest Harbor, Baltimore, MD

    Science.gov (United States)

    2010-05-17

    ..., Northwest Harbor at Baltimore, MD. The event will consist of approximately 15 teams rowing Chinese Dragon... Property Rights. Civil Justice Reform This rule meets applicable standards in sections 3(a) and 3(b)(2) of Executive Order 12988, Civil Justice Reform, to minimize litigation, eliminate ambiguity, and reduce...

  1. Comparative MD analysis of the stability of transthyretin providing insight into the fibrillation mechanism

    DEFF Research Database (Denmark)

    Sørensen, Jesper; Hamelberg, Donald; Schiøtt, Birgit

    2007-01-01

    used all-atom MD simulation and free energy calculations to study the initial phase of this process. We have calculated the free energy changes of the initial tetramer dissociation under different conditions and in the presence of thyroxine. We show that tetramer formation is indeed only...

  2. 77 FR 7182 - Scott W. Houghton, M.D.; Decision and Order

    Science.gov (United States)

    2012-02-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Scott W. Houghton, M.D.; Decision and Order On November 4, 2011, Chief.... Mulrooney, II. The Deputy Assistant Administrator, Drug Enforcement Administration (DEA or...

  3. 78 FR 12091 - Brian Earl Cressman, M.D.; Decision and Order

    Science.gov (United States)

    2013-02-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Brian Earl Cressman, M.D.; Decision and Order On December 5, 2012, Chief... the Drug Enforcement Administration (DEA or Government) issued an Order to Show Cause and...

  4. 76 FR 20025 - Alan H. Olefsky, M.D.; Denial of Application

    Science.gov (United States)

    2011-04-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Alan H. Olefsky, M.D.; Denial of Application On August 22, 2008, the Deputy Assistant Administrator, Office of Diversion Control, Drug Enforcement Administration, issued an Order...

  5. An endophytic taxol-producing fungus from Taxus media, Cladosporium cladosporioides MD2.

    Science.gov (United States)

    Zhang, Peng; Zhou, Peng-Peng; Yu, Long-Jiang

    2009-09-01

    Fermentation processes using taxol-producing fungi other than Taxus spp. may be an alternative way to produce taxol, which is an important antitumor agent used widely in the clinic setting. In this study, a taxol-producing endophytic fungus strain MD2 was isolated from the inner bark of Taxus media. Strain MD2 produced taxol when grown in potato dextrose liquid medium. The fungal taxol-which was analyzed by ultraviolet, high-performance liquid chromatography and mass spectrometry-was shown to be identical to authentic taxol and 10-deacetylbaccatin III. Further analysis with nuclear magnetic resonance (NMR) spectroscopy to show the chemical structure of the fungal taxol indicated that the fungal taxol produced an NMR spectrum identical to that of authentic taxol. Strain MD2 was identified as Cladosporium cladosporioides according to morphology of the fungal culture, characteristics of the spores, and analysis of 18S rDNA sequence. In addition, 10-deacetylbaccatin III-10-O-acetyl transferase gene of C. cladosporioides MD2 was cloned for the first time and was shown to share 99% identity with that of T. x media and 97% identity with that of T. wallichiana var. mairei.

  6. 78 FR 62678 - Morris W. Cochran, M.D.; Decision and Order

    Science.gov (United States)

    2013-10-22

    ... prescribing authority'' in the Alabama Court of Civil Appeals. . Respondent requested I deny the Government's... appealing such matters is the Alabama Court of Civil Appeals. Id. Sec. 34-24-380; see also Brunson, M.D. v. Alabama State Board of Medical Examiners, 69 So.3d 913, 914 (Ala. Civ. App. 2011). Here, Respondent had...

  7. 33 CFR 334.140 - Chesapeake Bay; U.S. Army Proving Ground Reservation, Aberdeen, Md.

    Science.gov (United States)

    2010-07-01

    ....140 Chesapeake Bay; U.S. Army Proving Ground Reservation, Aberdeen, Md. (a) Restricted area defined. The following indicates the limits of the waters of or adjacent to the Aberdeen Proving Ground, Maryland, and inside of which boundaries will lie the restricted area known as the Aberdeen Proving...

  8. 78 FR 60238 - Proposed Modification and Establishment of Restricted Areas; Aberdeen Proving Ground, MD

    Science.gov (United States)

    2013-10-01

    ...; Aberdeen Proving Ground, MD AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed..., within the existing restricted areas R-4001A and R- 4001B, at the U.S. Army's Aberdeen Proving Ground in... nonparticipating aircraft from a hazard to navigation in the Aberdeen Proving Ground airspace. DATES: Comments......

  9. Heat Flow Data Cruise MD72 RV Marion Dufresne over the Mascarene Ridge

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Data were gathered by the R/V Marion Dufresne in May and June of 1992 over the Mascarene Ridge in the Indian Ocean on cruise MD72/MASCAFLUX. Heat flow measurements...

  10. 77 FR 3118 - Security Zone; Choptank River and Cambridge Channel, Cambridge, MD

    Science.gov (United States)

    2012-01-23

    ... 3118-3121] [FR Doc No: 2012-1172] DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 [Docket No. USCG-2011-1164] RIN 1625-AA87 Security Zone; Choptank River and Cambridge Channel, Cambridge, MD..., U.S. Coast Guard, Captain of the Port Baltimore. [FR Doc. 2012-1172 Filed 1-20-12; 8:45 am]...

  11. Identification of key residues that confer Rhodobacter sphaeroides LPS activity at horse TLR4/MD-2.

    Directory of Open Access Journals (Sweden)

    Katherine L Irvine

    Full Text Available The molecular determinants underpinning how hexaacylated lipid A and tetraacylated precursor lipid IVa activate Toll-like receptor 4 (TLR4 are well understood, but how activation is induced by other lipid A species is less clear. Species specificity studies have clarified how TLR4/MD-2 recognises different lipid A structures, for example tetraacylated lipid IVa requires direct electrostatic interactions for agonism. In this study, we examine how pentaacylated lipopolysaccharide from Rhodobacter sphaeroides (RSLPS antagonises human TLR4/MD-2 and activates the horse receptor complex using a computational approach and cross-species mutagenesis. At a functional level, we show that RSLPS is a partial agonist at horse TLR4/MD-2 with greater efficacy than lipid IVa. These data suggest the importance of the additional acyl chain in RSLPS signalling. Based on docking analysis, we propose a model for positioning of the RSLPS lipid A moiety (RSLA within the MD-2 cavity at the TLR4 dimer interface, which allows activity at the horse receptor complex. As for lipid IVa, RSLPS agonism requires species-specific contacts with MD-2 and TLR4, but the R2 chain of RSLA protrudes from the MD-2 pocket to contact the TLR4 dimer in the vicinity of proline 442. Our model explains why RSLPS is only partially dependent on horse TLR4 residue R385, unlike lipid IVa. Mutagenesis of proline 442 into a serine residue, as found in human TLR4, uncovers the importance of this site in RSLPS signalling; horse TLR4 R385G/P442S double mutation completely abolishes RSLPS activity without its counterpart, human TLR4 G384R/S441P, being able to restore it. Our data highlight the importance of subtle changes in ligand positioning, and suggest that TLR4 and MD-2 residues that may not participate directly in ligand binding can determine the signalling outcome of a given ligand. This indicates a cooperative binding mechanism within the receptor complex, which is becoming increasingly

  12. 基于C#技术的MD5加密算法设计与实现%Design and Implementation of MD5 Algorithm Based on C# Technology

    Institute of Scientific and Technical Information of China (English)

    王倩丽

    2010-01-01

    本文对Message-Digest Algorithm 5(信息-摘要算法)进行了简要描述,并对MD5算法的原理进行了深入分析.同时采用目前流行的C#语言对MD5算法进行了具体的应用,实现了MD5加密演示系统.虽然MD5算法因王小云教授在2004国际密码学会议上发表的论文引起了很大的反响,但MD5算法仍然在数字签名、电子商务、信息加密等领域中有着非常广泛的应用.

  13. Research of incremental extraction based on MD5 and HASH algorithm%融入MD5的HASH线性获取增量算法研究

    Institute of Scientific and Technical Information of China (English)

    郭亮; 杨金民

    2014-01-01

    To achieve rapid incremental extraction of database, an algorithm which is blended MD5 in HASH linear scan-ning to obtain increment is put forward based on analyzing the traditional incremental extraction. Each record in database can be seen as a character string and it can be generated into hash table as duplicate record, which is explored in hash table through traditional record to obtain increment and decrease frequency of comparison. Meanwhile, the fingerprint of each record can be generated with using MD5 algorithm, which reduces the length of character string in every HASH algorithm and comparison and improves efficiency. This algorithm is applicably tested in ORACLE database and the result shows that it is improved on calculative efficiency at a large extent compared with traditional algorithm.%为了实现数据库中的快速增量提取,在剖析传统的增量提取方法上,提出了一种融入MD5的HASH线性扫描来获取增量的算法。数据库中的每条记录都可视为一个字符串,利用HASH算法生成备份记录的散列表,通过原始记录去散列表中探测来达到线性扫描就能获取增量的目的,减少了比对次数;同时利用MD5算法生成每条记录的“指纹”,降低了每次HASH运算和比对的字符串长度,提高了效率。对所提出算法在ORACLE数据库上进行了应用测试,结果表明该算法效率较传统方法有很大提高。

  14. Conversion of Claus plants of Kirkuk-Iraq to produce hydrogen and sulfur

    Energy Technology Data Exchange (ETDEWEB)

    Naman, S.A. [Chemistry Dept., Univ. of Duhok, Duhok (Iraq); Veziroglu, A. [International Association of Hydrogen Energy, Miami, Florida (United States)

    2009-07-01

    'Full text': Hydrogen production from rich sub-quality natural gas (SQNG) is visible technically with assessment of cost, safety and environmental toxicology analysis of hydrogen sulfide, is summarized. There are two Claus plants in Kirkuk-Iraq, converting hydrogen sulfide to elemental sulfur capacity of 2200 ton/day. One of these plants is working with only 400 ton/day and it is an old Claus process. The other is a modified Claus sulfur recovery process with a capacity of 1800 ton/day. Both of these plants operate with low efficiency due to lack of maintenance and the present situation in Iraq. Therefore, the agricultural area around Kirkuk is very polluted by this gas. Two pilot plants have been constructed inside the modified Claus plant in Kirkuk The first one is based on the flow system tube furnace reactor containing mixed Titanium oxide/sulfide with a cold trap for sulfur separation and a bath of 30% dithanolamine to separate and recycle H{sub 2}S from hydrogen. The second pilot plant consists of a thermal diffusion ceramic rod inside a silica column containing Zeolit 5A as a catalyst. This pilot plant also consists of a trap for continuous separation of sulfur and a system for separation of hydrogen from unreacted H{sub 2}S to recycle. The efficiency of conversion of H{sub 2}S to hydrogen and sulfur has been optimized as a function of catalyst type and mixture, temperature of furnace, flow rate of gas and reactor materials until the efficiency reaches more than 97%. The Kirkuk natural gas consists of a mixture of CO{sub 2} 10% and H{sub 2}S 12%. We found that these pilot plants were suitable with Cadmium chalcogens catalysts to produce hydrogen, methane, ethane and sulphur, but with lower efficiency than H{sub 2}S decomposition only. Our aim in the second pilot plant, which consists of a silica column, was to supply the heat by solar energy concentrator instead of electricity as our catalyst needs 450 {sup o}C. and the solar intensity is about

  15. Analysis of DNA methylation and virus induced DNA methylation change in MD-resistant and –susceptible chickens

    Directory of Open Access Journals (Sweden)

    Juan eLuo

    2012-02-01

    Full Text Available Marek’s disease (MD is a lymphoproliferative disease induced by Marek’s disease virus (MDV infection. With the less efficacy of vaccine in MD prevention, genetically selected MD-resistant chicken becomes more and more important in MD control. To elucidate the mechanism of MD-resistance, lots of researches were focused on the different genetic differences between the resistant and susceptible chickens. However, less is known about the epigenetic features. By using pyrosequencing, the promoter methylations of 18 candidate genes in MD-resistant (L63 and –susceptible (L72 chicken were examined, we found that most of the genes have higher methylation level in L72. MDV infection changed the expressions of all three methyltransferases (DNMT1, DNMT3a and DNMT3b, while the up-regulation of DNMT1 was only shown in L72 and down-regulation of DNMT3b only in L63 at 21dpi. Interestingly, a dynamic change of promoter methylation was observed in most of the genes in both lines during MDV life cycle. Seven genes, including HDAC9, GH, STAT1, CIITA, FABP3, LATS2 and H2Ac, showed different methylation behavior between L63 and L72. In summary, the findings from this study suggested that DNA methylation heterogeneity exists in MD-resistance and –susceptibility chicken, and MDV infection also induces differential methylation alterations, both indicating epigenetic factor may involve in MD.

  16. 33 CFR 334.170 - Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range, Naval Research Laboratory.

    Science.gov (United States)

    2010-07-01

    ... of Chesapeake Beach, Md.; firing range, Naval Research Laboratory. 334.170 Section 334.170 Navigation... RESTRICTED AREA REGULATIONS § 334.170 Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range... on the west by the shore of Chesapeake Bay. (2) Area B. The sector of a circle bounded by radii of...

  17. The Convergence of Business and Medicine: A Study of MD/MBA Programs in the United States

    Science.gov (United States)

    Keogh, Timothy J.; Martin, William Marty

    2011-01-01

    The purpose of this paper is to identify the convergence of business and medical education and describe the curricula of MD/MBA (Medical Doctor/Master of Business Administration) programs in the US. The focus of this study is to provide a guide to dual MD/MBA programs for physicians, aspiring physicians, policy makers and healthcare organizations.…

  18. 苹果光响应转录因子MdHY5表达及蛋白互作分析%Expression and Protein Interaction Analysis of Light Responsive bZIP Transcription FactorMdHY5

    Institute of Scientific and Technical Information of China (English)

    李慧峰; 王小非; 冉昆; 何平; 王海波; 李林光

    2014-01-01

    Objective]Cloning of the key light responsive bZIP (Basic-leucine zipper) transcription factors fromMalus domestica Borkh, gene expression and protein interaction analysis, which were determined to identify the function and molecular mechanism ofMdHY5.[Method]First, semi-quantitative primers used for detecting expression levels were designed from the apple in order to identify the light-responsivebZIP genes. Differentially screened and identified a light responsive gene named as MdHY5 based on comparative analysis of homologous. Subsequently, the primers were designed to clone theMdHY5 gene. Phylogenetic relationship including the MdHY5 protein withArabidopsis bZIP proteins was analyzed using MEGA5 and the multiple alignment of bZIP domain was constructed, while the conserved protein domain was predicted, spatio expression analysis was made to detect the MdHY5 in different organs. The expression ofMdHY5 in response to various light qualities was detected by semi-quantitative RT-PCR based on promoter prediction analysis, combined with theArabidopsis microarray database. Finally,MdHY5 gene was inserted into the prokaryotic vectorpGEX-4T-1, and IPTG was used to induce the fusion protein expression inE.coliBL21. Then the fusion protein was purified and detected by Western blot. The interaction between MdHY5 and MdCOP1 was detected by pull down assay.[Result]A bZIP transcription factor was isolated in apple through the light response analysis. Phylogenetic relationship showed that MdHY5 is a homolog ofArabidopsis AtHY5. This gene is located on chromosome 12 of apple genome, with the gene number MDP0000586302,MdHY5 gene contains four exons and three introns in genome structure, which is similar to its homolog. The length of the cDNA is 1 112 bp, with 214 bp in the 5′ untranslated region, 403 bp in 3′ untranslated region, and 495 bp of open reading frame, which encode a 164 amino acid residues. MdHY5 contains a leucine zipper structure typical (bZIP domain) in the C

  19. Anmeldelse af Claus Friisberg: Ideen om et frit Danmark. Den nationalliberale bevægelses ideologi og politik - især i den formative periode (Varde 2003)

    DEFF Research Database (Denmark)

    Busck, Steen

    2003-01-01

    Anmeldelse af Claus Friisberg: Ideen om et frit Danmark. Den nationalliberale bevægelses ideologi og politik - især i den formative periode (Varde 2003)......Anmeldelse af Claus Friisberg: Ideen om et frit Danmark. Den nationalliberale bevægelses ideologi og politik - især i den formative periode (Varde 2003)...

  20. A recombinant field strain of Marek's disease (MD) virus with reticuloendotheliosis virus long terminal repeat insert lacking the meq gene as a vaccine against MD.

    Science.gov (United States)

    Su, Shuai; Cui, Ning; Zhou, Yu; Chen, Zimeng; Li, Yanpeng; Ding, Jiabo; Wang, Yixin; Duan, Luntao; Cui, Zhizhong

    2015-01-29

    Marek's disease virus (MDV) GX0101, which is a field strain with a naturally occurring insertion of the reticuloendotheliosis virus (REV) long terminal repeat (LTR) fragment, shows distinct biological activities. Deletion of the meq gene in GX0101 contributes to its complete loss of pathogenicity and oncogenicity in SPF chickens, but this virus has a kanamycin resistance gene (kan(r)) residual at the site of meq gene. In the present study, the kan(r) was knocked out and a meq-null virus with a good replicative ability termed SC9-1 was selected. In vivo studies showed that SC9-1 had no pathogenicity or tumorigenicity to chickens. There were no obvious impacts on chicken weight, immune organ index or antibody levels induced by avian influenza virus (AIV)/newcastle disease virus (NDV) inactivated vaccines compared with the control group. The SC9-1 virus provided superior protection than CVI988/Rispens vaccine in both SPF chickens and Hy-line brown chickens when challenged with a very virulent MDV (rMd5 strain). There was no obvious change in SC9-1 protection against MDV rMd5 in SPF chickens after 20 passages in chicken embryonic fibroblast cells (CEFs). In conclusion, SC9-1 is a safe and effective vaccine candidate for the prevention of Marek's disease.