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Sample records for claus manniche md

  1. Mannich reaction: A versatile and convenient approach to bioactive skeletons

    Indian Academy of Sciences (India)

    Selva Ganesan Subramaniapillai

    2013-05-01

    This review gives an insight into the recent applications of Mannich reaction and its variants in the construction of bioactive molecules. Emphasis is given to the Mannich reaction that provides bioactive molecules and/or modifies the property of an existing bioactive molecule. The role of Mannich reaction in the construction of antimalarial, antitumour, antimicrobial, antitubercular, antiinflammatory and anticonvulsant molecules and also the significance of aminoalkyl Mannich side chain on the biological property of molecules is discussed here.

  2. Biosynthesis of some Mannich bases

    Directory of Open Access Journals (Sweden)

    Bruna S. D. R. Aranha

    2012-06-01

    Full Text Available The Mannich reaction is extremely useful to form molecules that contain nitrogen groups. Currently, there is a great interest turned to this class of compounds due to its biological properties. The recent literature reports that the utilization of enzymes can be an adequate methodology on this type of reaction. According to the exposed above and with the intention of synthesizing the -aminoketones, some catalysts like Chymosin and also some microorganisms such as Saccharomyces cerevisiae, (sourdough bread and Lactobacilos (ATCC 90827LA10N19.10-E.U.A were applied. These reactions were carried out by using water as solvent at room temperature excelling for the Green Chemistry principles. Figure 1 shows the reaction scheme involving 1 eq.mol of aniline, 1,3 eq.mol of formaldehyde, 10 ml of water and 0,25g of the catalyst during four days. The reaction furnished satisfactory yields which are in accordance with the literature data.

  3. Mannich Bases: An Important Pharmacophore in Present Scenario

    Directory of Open Access Journals (Sweden)

    Suman Bala

    2014-01-01

    Full Text Available Mannich bases are the end products of Mannich reaction and are known as beta-amino ketone carrying compounds. Mannich reaction is a carbon-carbon bond forming nucleophilic addition reaction and is a key step in synthesis of a wide variety of natural products, pharmaceuticals, and so forth. Mannich reaction is important for the construction of nitrogen containing compounds. There is a number of aminoalkyl chain bearing Mannich bases like fluoxetine, atropine, ethacrynic acid, trihexyphenidyl, and so forth with high curative value. The literature studies enlighten the fact that Mannich bases are very reactive and recognized to possess potent diverse activities like anti-inflammatory, anticancer, antifilarial, antibacterial, antifungal, anticonvulsant, anthelmintic, antitubercular, analgesic, anti-HIV, antimalarial, antipsychotic, antiviral activities and so forth. The biological activity of Mannich bases is mainly attributed to α, β-unsaturated ketone which can be generated by deamination of hydrogen atom of the amine group.

  4. Stereoselective bioreduction of someMannich bases

    Directory of Open Access Journals (Sweden)

    Bruna S. D. R. Aranha

    2012-06-01

    Full Text Available The chemic reaction that happen on the live organism (plants, superior animals and microorganisms produce various chiral substances such as pheromones, antibiotics and others. After the eighties, with the break of the dogma referent to the enzymatic utilization only in aqueous medias, diverse enzyme application were revealed in other reaction medias, what allowed new studies turned to enzymatic application in organic chemistry. Such studies revealed that these biocatalysts presented high selectivity in these medias, no only about to the chemoselectivity but especially to the enantioselectivity. According to what was exposed, this work aimed to execute the bioreduction of some Mannich bases using the microorganism Saccharomyces cerevisiae (sourdough bread. Scheme 1 shows the reaction scheme involving 1 eq.mol of the b-aminocarbonilated product, 10 mL of   the suitable solvent and 0,5g of the biocatalys during four days at room temperature. These reactions presented satisfactory yields, which are in accordance with the literature.

  5. Claus Bonderup

    DEFF Research Database (Denmark)

    Fisker, Anna Marie; Hvejsel, Marie Frier; Tvedebrink, Tenna Doktor Olsen

    -oriented architectural projects within Urban Farming in which the students will initially work with the subject as master’s students, but later, hopefully, as PhD students. Also, I have wished for a long time to give Claus Bonderup the recognition he deserves! His view of architecture, his knowledge and his way of...... house that serves as a basis for this project with its unique architectural models for the International Architecture Exhibition. Claus’ Duck House has, thus, in theory and practice alike, become the foundation for the new architectural models, and his thoughts on design have contributed to a fruitful...

  6. Green chemistry approach to the synthesis of potentially bioactive aminobenzylated Mannich bases through active hydrogen compounds

    OpenAIRE

    S. L. VASOYA; P. T. CHOVATIA; D. H. PUROHIT; H. S. JOSHI

    2005-01-01

    An efficient and high yield method for the synthesis of aminobenzylated Mannich bases is described. The synthesis occurs in aqueous medium at 0 ºC. The compounds show moderate antitubercular and antimicrobial activities.

  7. Green chemistry approach to the synthesis of potentially bioactive aminobenzylated Mannich bases through active hydrogen compounds

    Directory of Open Access Journals (Sweden)

    S. L. VASOYA

    2005-10-01

    Full Text Available An efficient and high yield method for the synthesis of aminobenzylated Mannich bases is described. The synthesis occurs in aqueous medium at 0 ºC. The compounds show moderate antitubercular and antimicrobial activities.

  8. Promotion of a Ti-Mediated Mannich Reaction by a Proton Source.

    Science.gov (United States)

    Limanto, John; Yoshikawa, Naoki; Reamer, Robert A; Tan, Lushi; Brunskill, Andrew; Reibarkh, Mikhail

    2016-01-15

    Low temperature NMR studies revealed that a diastereoselective Mannich reaction between a phenyl oxazolidone-derived titanium enolate and an aromatic aldimine was found to occur only after introduction of a proton source. While various protic additives could be used to promote the transformation, the best results were obtained using AcOH to afford the corresponding Mannich products in high diastereoselectivities and yields. PMID:26656787

  9. Covered Clause Elimination

    CERN Document Server

    Heule, Marijn; Biere, Armin

    2010-01-01

    Generalizing the novel clause elimination procedures developed in [M. Heule, M. J\\"arvisalo, and A. Biere. Clause elimination procedures for CNF formulas. In Proc. LPAR-17, volume 6397 of LNCS, pages 357-371. Springer, 2010.], we introduce explicit (CCE), hidden (HCCE), and asymmetric (ACCE) variants of a procedure that eliminates covered clauses from CNF formulas. We show that these procedures are more effective in reducing CNF formulas than the respective variants of blocked clause elimination, and may hence be interesting as new preprocessing/simplification techniques for SAT solving.

  10. RUTHENIUM-CATALYZED TANDEM OLEFIN MIGRATION-ALDOL AND MANNICH-TYPE REACTIONS IN IONIC LIQUID.

    Science.gov (United States)

    In the presence of a catalytic amount of RuCl2(PPh3)3, a cross-coupling of 3-buten-2-ol with aldehydes and imines was developed via a tandem olefin migration--aldol--Mannich reaction in bmim[PF6]. With In(OAc)3 as a co-catalyst, a-vinylbenzyl alcohol and aldehydes underwent sim...

  11. Synthesis and NO production inhibition of novel Mannich base derivatives of irisolidone

    Institute of Scientific and Technical Information of China (English)

    Jiao Wang; Ying Zhong; Lu Liu; Xin Quan Ji; Zhi Guo Zhang

    2008-01-01

    Five new C-8 Mannich base derivatives of irisolidone 2a-2e were synthesized and their nitric oxide (NO) production inhibitory activity was evaluated.Compounds 2a,2b,2c and 2e displayed stronger activities in vitro than the parent compound irisolidone.

  12. ALDOL- AND MANNICH-TYPE REACTIONS VIA IN SITU OLEFIN MIGRATION IN IONIC LIQUID

    Science.gov (United States)

    An aldol-type and a Mannich-type reaction via the cross-coupling of aldehydes and imines with allylic alcohols catalyzed by RuCl2(PPh3)3 was developed with ionic liquid as the solvent. The solvent/catalyst system could be reused for at least five times with no loss of reactiv...

  13. Stereoselective access to heteroarylmethylene-substituted pyrrolidines: fully organocatalytic Mannich-hydroamination reactions.

    Science.gov (United States)

    Jean, Alexandre; Blanchet, Jérôme; Rouden, Jacques; Maddaluno, Jacques; De Paolis, Michaël

    2013-02-25

    A one-pot sequence of organocatalytic transformations delivers heteroarylmethylene-substituted pyrrolidines with high stereo- and enantioselectivity. A Mannich coupling of N-heteroarylalkyne aldehydes with aldimine and an original metal-free hydroamination of the resulting adducts are the key transformations of the process delivering highly functionalized molecules with high potential for synthetic applications. PMID:23340658

  14. Diastereoselective Ugi reaction of chiral 1,3-aminoalcohols derived from an organocatalytic Mannich reaction

    Science.gov (United States)

    Caputo, Samantha; Basso, Andrea; Moni, Lisa; Riva, Renata; Rocca, Valeria

    2016-01-01

    Summary Enantiomerically pure β-aminoalcohols, produced through an organocatalytic Mannich reaction, were subjected to an Ugi multicomponent reaction under classical or Lewis acid-promoted conditions with diastereoselectivities ranging from moderate to good. This approach represents a step-economical path to enantiomerically pure, polyfunctionalized peptidomimetics endowed with three stereogenic centers, allowing the introduction of five diversity inputs. PMID:26877816

  15. Relative Clauses and Noun-Modifying Clauses in Chantyal

    OpenAIRE

    Noonan, Michael

    2008-01-01

    The document contains a talk handout of a lecture held by Michael Noonan at the meeting on Relative Clauses and Noun-Modifying Clauses: A Cross-linguistic Investigation in Stanford University on March 22-24, 2008. It deals with relative and nominal clauses in the Chantyal language.

  16. Muscular Dystrophy (MD)

    Science.gov (United States)

    ... Awards Enhancing Diversity Find People About NINDS NINDS Muscular Dystrophy Information Page Clinical Trials Finding the Optimum Regimen ... en Español Additional resources from MedlinePlus What is Muscular Dystrophy? The muscular dystrophies (MD) are a group of ...

  17. Iterative Specialisation of Horn Clauses

    DEFF Research Database (Denmark)

    Nielsen, Christoffer Rosenkilde; Nielson, Flemming; Nielson, Hanne Riis

    2008-01-01

    We present a generic algorithm for solving Horn clauses through iterative specialisation. The algorithm is generic in the sense that it can be instantiated with any decidable fragment of Horn clauses, resulting in a solution scheme for general Horn clauses that guarantees soundness and termination...

  18. An Overview of Relative Clauses

    Institute of Scientific and Technical Information of China (English)

    肖飒

    2015-01-01

    Relative clause is one kind of important modifiers among English grammar. It is a widely used clauses in English con-text. In order to get an overview of relative clause, this essay will analyze it in terms of form, meaning and use.

  19. Iterative Specialisation of Horn Clauses

    DEFF Research Database (Denmark)

    Nielsen, Christoffer Rosenkilde; Nielson, Flemming; Nielson, Hanne Riis

    We present a generic algorithm for solving Horn clauses through iterative specialisation. The algorithm is generic in the sense that it can be instantiated with any decidable fragment of Horn clauses, resulting in a solution scheme for general Horn clauses that guarantees soundness and termination...

  20. Teaching French Noun Clauses.

    Science.gov (United States)

    Mayer, Edgar N.

    This paper attempts to give a unified view of the workings of noun clauses. These are considered according to three main types corresponding to three different kinds of source sentences. All three types can be used in any usual noun-phrase function, especially subject, direct object, and prepositional object. Four factors which complicate the…

  1. Organic Bill Conscience Clause

    Directory of Open Access Journals (Sweden)

    María Teresa Riofrío Martínez-Villalba

    2012-12-01

    Full Text Available By the close relationship between the right to life of the unborn child and the right to act in conscience of doctors, nurses and others at one time can be commanded to kill an unborn, we quote an interesting project of law about Conscience Clause.

  2. Reação de Mannich: Metodologia Clássica na Formação de Ligação Carbono-Carbono

    Directory of Open Access Journals (Sweden)

    João Francisco Allochio Filho

    2013-08-01

    Full Text Available The Mannich reaction is a classical method for the preparation of b-aminoketones and aldeydes (Mannich bases and, as such, is one the most important reaction in organic chemistry. The resulting Mannich bases are of particular interest due to their biological activity, use as synthetic building blocks, and precursors of valuable pharmaceuticals products. In this context, various elegant stereoselective α-aminoalkylations have been developed.

  3. Collide and Squeeze MD

    CERN Document Server

    Gorzawski, Arkadiusz; Papotti, Giulia; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; Pieloni, Tatiana; CERN. Geneva. ATS Department

    2015-01-01

    Colliding the beams during the squeeze to profit from Landau damping due to head--on beam-beam and b* leveling are two operational modes that may have to be used in a not so distant future at the LHC. This MD aimed at improving the process control during the squeeze with much improved handling of reference for the orbit feedback system and at evaluating instruments and techniques to maintain the beam in collisions with active feedback on a good observable.

  4. Novel Mannich bases bearing pyrazolone moiety. Synthesis, characterization and electrochemical studies

    Directory of Open Access Journals (Sweden)

    KRISHNA NAIK

    2013-04-01

    Full Text Available The present investigation describes a series of new {4-[3-Methyl-5-oxo-4-(4|-substituted phenyl hydrazono-4,5-dihydro-pyrazol-1-yl]-phenoxy}-acetic acid (2-oxo-1-piperidine-1-ylmethyl-1,2-dihydro–indol-3-ylidene-hydrazides synthesized by the Mannich reaction of {4-[3-Methyl-5-oxo-4-(4|-substituted phenyl hydrazono-4,5-dihydro-pyrazol-1-yl]-phenoxy}-acetic acid (2-oxo-1,2-dihydro-indol-3-ylidene-hydrazide with aqueous formaldehyde and a solution of piperidine in dimethylformamide. These novel Mannich bases were characterized by elemental analysis, IR, 1H NMR and mass spectral data. Electrochemical behavior of these compounds were studied by two techniques namely polarography and cyclic voltammetry. The results from both the techniques were compared and the reduction mechanism in acidic as well as basic medium was proposed.

  5. Study on the Synthesis and Corrosion Inhibition Performance of Mannich-Modified Imidazoline

    Directory of Open Access Journals (Sweden)

    Xiangjun Kong

    2016-07-01

    Full Text Available A novel Mannich-modified imidazoline (MMI as cationic emulsifier was synthesised for corrosion harm reduction, through three steps — acylation, cyclization, and Mannich reaction. The surface activity was characterized by determination of surface tensions and critical micelle concentration (CMC. The corrosion inhibition performance of five types of steels in the simulated corrosion solution in the presence of the MMI was investigated by static weight loss tests. The results showed that the MMI had good surface activities, with CMC of 19.8 μg g−1 and surface tension of 36.4 mN m−1. The corrosion test results indicated that the corrosion rates of different materials were decreased significantly, and degrees of corrosion inhibition were always higher than 80.0 %. The main inhibition mechanism was most likely due to the adsorption of the corrosion inhibitor on the steel surface, leading to the prevention of corrosion medium from the metal surface.

  6. Trimerization catalysis of phenylisocyanate in the presence of phenolic mannich bases

    Energy Technology Data Exchange (ETDEWEB)

    Selivanov, A.V.; Zenitova, L.A.; Bakirova, I.N.; Kirpichnikov, P.A.

    1988-11-01

    The kinetics of the cyclic trimerization of phenylisocyanate in the presence of phenolic Mannich bases have been studied by IR spectroscopy; a catalysis mechanism for the reaction is proposed. It was found that in order for trimerization to occur the catalyst molecule must contain both a hydroxyl group and a tertiary nitrogen atom, which leads to reaction at the OH group of the catalyst and its conversion via a urethane derivative to an allophanate; the latter species undergoes tautomeric rearrangement to a bipolar ion, which is the actual catalysis site. The effects of the number of aminomethyl, hydroxyl, and other electron-donating and electron-withdrawing substituents on the structure of Mannich bases have also been investigated.

  7. Synthesis, Characterization and Biological Evaluation of 1, 2-Disubstituted Benzimidazole Derivatives using Mannich Bases

    OpenAIRE

    Reddy, B. Anil

    2010-01-01

    The ring system in which a benzene ring is fused to the 4,5-positions of imidazole is designated as benzimidazole. Condensations of 2-substituted benzimidazole derivatives were synthesized by different carboxylic acids using Mannich base and anti-inflammatory activity. The various positions on the benzimidazole ring are numbered in the manner indicated with the imino function as number one. The formations of the product were conformed by the analytical and spectral data.

  8. Structural studies on Mannich bases of 2-Hydroxy-3,4,5,6-tetrachlorobenzene. An UV, IR, NMR and DFT study. A mini-review

    DEFF Research Database (Denmark)

    Hansen, Poul Erik; Spanget-Larsen, Jens

    2016-01-01

    Mannich bases of 2-Hydroxy-3,4,5,6-tetrachlorobenzene are chosen as an exemplary case for tautomeric Mannich bases. Molecular structures are calculated. OH stretching frequencies are rationalized based on DFT calculations. Intrinsic deuterium isotope effects on 13C chemical shifts in the M-form a...

  9. Discriminative ability of two different external anchors: improvement appears better than importance

    DEFF Research Database (Denmark)

    Lauridsen, Henrik Hein

    2009-01-01

    Title:    Discriminative ability of two different external anchors: improvement appears better than importance. Authors and affiliation: Henrik H. Lauridsen, DC, MSc, PhD*, Claus Manniche, MD, DMSc‡, Werner Vach, PhD §, Niels Grunnet-Nilsson DC, MD, PhD*, Jan Hartvigsen, DC, PhD*† * Clinical...

  10. Discriminative ability of two different external anchors: improvement appears better than importance

    DEFF Research Database (Denmark)

    Lauridsen, Henrik Hein

    Title:    Discriminative ability of two different external anchors: improvement appears better than importance. Authors and affiliation: Henrik H. Lauridsen, DC, MSc, PhD*, Claus Manniche, MD, DMSc‡, Werner Vach, PhD §, Niels Grunnet-Nilsson DC, MD, PhD*, Jan Hartvigsen, DC, PhD*†   * Clinical...

  11. ADT fast losses MD

    CERN Document Server

    Priebe, A; Dehning, B; Redaelli, S; Salvachua Ferrando, BM; Sapinski, M; Solfaroli Camillocci, M; Valuch, D

    2013-01-01

    The fast beam losses in the order of 1 ms are expected to be a potential major luminosity limitation for higher beam energies after the LHC long shutdown (LS1). Therefore a Quench Test is planned in the winter 2013 to estimate the quench limit in this timescale and revise the current models. This experiment was devoted to determination the LHC Transverse Damper (ADT) as a system for fast losses induction. A non-standard operation of the ADT was used to develop the beam oscillation instead of suppressing them. The sign flip method had allowed us to create the fast losses within several LHC turns at 450 GeV during the previous test (26th March 2012). Thus, the ADT could be potentially used for the studies of the UFO ("Unidentied Falling Object") impact on the cold magnets. Verification of the system capability and investigations of the disturbed beam properties were the main objectives of this MD. During the experiment, the pilot bunches of proton beam were excited independently in the horizontal and vertical ...

  12. 48 CFR 46.710 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... performance specifications or design are of major importance; a fixed-price supply, service, or research and... QUALITY ASSURANCE Warranties 46.710 Contract clauses. The clauses and alternates prescribed in this... insert a clause substantially the same as the clause at 52.246-20, Warranty of Services, in...

  13. MD5算法研究%MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    张裔智; 赵毅; 汤小斌

    2008-01-01

    随着网络技术的迅速发展,信息加密技术已成为保障网络安全的一种重要手段,加密算法已经成为人们的一个研究热点.本文对MD5算法进行了深入研究,介绍MD5算法的产生背景、应用及其算法流程,并提出了MD5算法的一个改进方案.

  14. Defective Arbitration Clauses in International Commercial Contracts

    OpenAIRE

    Tolkušinas, Kasparas

    2011-01-01

    Usually in a drafting process of a contract arbitration clause is left at the end of a contract. Sometimes it happens that parties really do not wish start discussions on how should arbitration clause look like or what details should it contain, because either parties think they would never come to a conflict or they are short in time and leave arbitration clause unconsidered. Absence of proper attention when drafting arbitration clauses is likely to give rise to defective arbitration clauses...

  15. Synthesis and Anticonvulsant Activity of Various Mannich and Schiff Bases of 1,5-Benzodiazepines

    Directory of Open Access Journals (Sweden)

    Surendra N. Pandeya

    2012-01-01

    Full Text Available Benzodiazepines have a various behavioral effects in addition to their anxiolytic action. There is every reason to believe that the BZ/GABA receptor complex is involved in these effects, since GABAmimetic manipulations modify the effect of BZ in tests of convulsive activity, motor function, and appetitive behavior. 1,5-Benzodiazepines are biologically important molecules and are extensively used clinically as analgesic, hypnotic, sedative, and antidepressive agents. Hence, 1,5-Benzodiazepines were synthesized by condensation of o-phenylenediamine and ketones, for example, cyclohexanone and acetone in presence of sulfated zirconia (catalyst. Mannich bases were synthesized with acetophenone, p-nitroacetophenone, p-chloroacetophenone, and formaldehyde. Schiff bases were synthesized using Mannich base of 1,5-benzodiazepines with p-chloroaniline and p-chlorophenylsemicarbazide in the presence of glacial acetic acid. All the synthesized compounds were characterized by 1H NMR and IR spectral analyses. All the synthesized derivatives were evaluated at the dose of 30 mg/kg b.w for anticonvulsant activity by isoniazid induced convulsion model, and the compounds NBZD-3 and NBZD-8 were found to be the most active among all compounds. Among all the synthesized derivatives, compounds NBZD-13 and NBZD-17 were found to be the most active among all compounds using thiosemicarbazide induced model. Although NBZD-8, NBZD-10, and NBZD-18 are the compounds which had shown good anticonvulsant activity and have an advantage over that, they were not sedative.

  16. 78 FR 14547 - Praxedes E. Alverez Santiago, M.D., Daniel Perez Brisebois, M.D., Jorge Grillasca Palou, M.D...

    Science.gov (United States)

    2013-03-06

    ... Praxedes E. Alverez Santiago, M.D., Daniel Perez Brisebois, M.D., Jorge Grillasca Palou, M.D., Rafael Garcia Nieves, M.D., Francis M. Vazques Roura, M.D., Angel B. Rivera Santos, M.D., Cosme D. Santos Torres, M.D., and Juan L. Vilaro Chardon, M.D.; Analysis of Agreement Containing Consent Order To Aid...

  17. Synthesis and Biological Activity of 1,3,4-Oxadiazole Mannich Bases Containing Pyrimidine Rings%含嘧啶环的1,3,4-噁二唑 Mannich 碱的合成及生物活性

    Institute of Scientific and Technical Information of China (English)

    沈生强; 孙晓红; 刘源发; 陈邦; 靳如意; 马海霞

    2014-01-01

    1,3,4-Oxadiazole derivatives were reported to possess a broad spectrum of biological activities, such as antifungal, antibacterial, antiviral and antitubercular. Mannich bases had also been reported as poten-tial biological agents, they were applicated in the fields of synthetic study and medicinal chemistry. In recent years, Mannich bases containing 1,3,4-oxadiazole ring had attracted a lot of attention and many Mannich ba-ses of 1,3,4-oxadiazole bearing heterocycle scaffold were reported to have special bioactivity. Nevertheless, literature revealed that there were no reports of a molecular scaffold that Mannich base of 1,3,4-oxadiazole bearing pyrimidine. Prompted by these observations, a series of 1,3,4-oxadiazole derivatives containing py-rimidine( E1-E15) was synthesized from 5-aryl-1,3,4-oxadiazole-2-thione ( C1-C3), formaldehyde and substituted aminopyrimidine ( D1-D5) by Mannich reaction. 5-Aryl-1,3,4-oxadiazole-2-thione derivatives (C1-C3) were prepared from aromatic acids as the starting material via esterification, hydrazinolysis and cy-clization. The structures of all title compounds were confirmed by elemental analysis, IR, 1 H NMR tech-niques. Furthermore, their biological activities to four vegetable pathogens containing Gibberll nicotiancola, Gibberlla saubinetii, Fusarium oxysporium f. sp. niveum, Pythium solani had been tested. The preliminary re-sults indicated that most of the compounds exhibit relatively good fungicidal activities, especially compounds E3 and E8 showed better biological activity than triazolone.%以芳香酸为原料,通过酯化、肼解及环化反应制得中间体5-芳基取代-1,3,4-噁二唑-2-硫酮(C1~C3),然后中间体与甲醛和取代氨基嘧啶(D1~ D5)发生 Mannich 反应得到一系列新型含有嘧啶环的1,3,4-噁二唑类衍生物(E1~ E15)。所得目标化合物的结构经元素分析、 IR 及1 H NMR 确认。初步的生物活性测定结果表明,大部分目标化合物对植物病原菌有很好

  18. 48 CFR 4.303 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... MATTERS Paper Documents 4.303 Contract clause. Insert the clause at 52.204-4, Printed or Copied Double-Sided on Recycled Paper, in solicitations and contracts that exceed the simplified acquisition threshold....

  19. 48 CFR 1632.617 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... HEALTH BENEFITS ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Debts 1632.617 Contract clause. The clause at (FAR) 48 CFR 52.232-17 will be modified in all FEHBP...

  20. 48 CFR 3009.171-9 - Clause.

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    2010-10-01

    ... Contractors 3009.171-9 Clause. Insert the clause (HSAR) 48 CFR 3052.209-76, Prohibition on Federal Protective Service guard services contracts with business concerns owned, controlled, or operated by an...

  1. 48 CFR 3019.708 - Contract clauses.

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    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Contract clauses. 3019.708... ACQUISITION REGULATION (HSAR) SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 3019.708 Contract clauses....

  2. 48 CFR 16.307 - Contract clauses.

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    ... commercial item) is contemplated. If the contract is with an educational institution, modify the clause by... AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 16.307 Contract clauses. (a)(1)...

  3. 48 CFR 3.1004 - Contract clauses.

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    2010-10-01

    ... BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Contractor Code of Business Ethics and Conduct 3.1004 Contract clauses. (a) Insert the clause at FAR 52.203-13, Contractor Code of Business Ethics and...

  4. MANDATORY CLAUSES IN MEDIATION CONTRACTS

    Directory of Open Access Journals (Sweden)

    VERONICA STOICA

    2011-04-01

    Full Text Available The mediation contract – a contract by which conflicting parties agree, in conjunction with a mediator, upon conflict resolve in an amiable manner through the agency of mediation, under due efforts on the mediator’s part, in exchange for payment of a fee by the parties – must contain a set of mandatory clauses in compliance with legal provisions, Article 45 of Law no. 192/2006. In the absence of one of said clauses, sanction by absolute annulment is imposed.

  5. 48 CFR 904.7201 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 904.7201... MATTERS Public Affairs 904.7201 Contract clause. The contracting officer shall insert the clause at 952.204-75, Public Affairs, in solicitations and contracts that require the contractor to...

  6. 48 CFR 871.212 - Contract clauses.

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    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 871.212... Rehabilitation and Employment Service 871.212 Contract clauses. Contracting officers must use the following clauses, as appropriate, in solicitations and contracts for vocational rehabilitation and...

  7. 48 CFR 1339.107 - Contract clauses.

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    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1339.107... CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY General 1339.107 Contract clauses. Insert clause 1352.239-70, Software License Addendum, in all contracts when the primary purpose is to purchase new software...

  8. 48 CFR 1346.710 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1346.710 Section 1346.710 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 1346.710 Contract clauses. The warranty clauses and alternates under FAR Subpart...

  9. 48 CFR 923.103 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 923.103... Contract clauses. Insert the clause at 952.223-78, Sustainable Acquisition Program, or its Alternate I, in all contracts under which the contractor operates Government-owned facilities or...

  10. 48 CFR 846.710 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 846.710 Section 846.710 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 846.710 Contract clauses. The contracting officer shall insert the clause...

  11. 48 CFR 923.903 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 923.903... Environmental Management Systems § 923.903 Contract clause. The FAR Environmental Management Systems clause at 52.223-XX should be used in contracts where the contractor operates a DOE site or portion...

  12. 48 CFR 53.111 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Contract clause. 53.111... AND FORMS FORMS General 53.111 Contract clause. Contracting officers shall insert the clause at 52.253-1, Computer Generated Forms, in solicitations and contracts that require the contractor to...

  13. 48 CFR 811.503 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 811.503... ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Liquidated Damages 811.503 Contract clause. When the contracting... contracting officer must include the clause in 852.211-74, Liquidated damages, in the contract....

  14. 48 CFR 903.971 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 903.971... Contract clause. The contracting officer shall insert the clause at 952.203-70, Whistleblower Protection for Contractor Employees, in contracts that involve work to be done on behalf of DOE directly...

  15. 48 CFR 837.403 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 837.403... OF CONTRACTING SERVICE CONTRACTING Nonpersonal Health Care Services 837.403 Contract clause. The contracting officer shall insert the clause at 852.237-7, Indemnification and medical liability insurance,...

  16. 48 CFR 822.305 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 822.305... PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Contract Work Hours and Safety Standards Act 822.305 Contract clause. The contracting officer shall insert the clause at 852.222-70, Contract...

  17. 48 CFR 233.215 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clause. 233.215....215 Contract clause. Use Alternate I of the clause at FAR 52.233-1, Disputes, when— (1) The... (v) Tracked combat vehicles (vi) Related electronic systems; (2) The contracting officer...

  18. 48 CFR 19.1407 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clauses. 19.1407... PROGRAMS SMALL BUSINESS PROGRAMS Service-Disabled Veteran-Owned Small Business Procurement Program 19.1407 Contract clauses. The contracting officer shall insert the clause 52.219-27, Notice of Total...

  19. 48 CFR 19.1104 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clause. 19.1104... PROGRAMS SMALL BUSINESS PROGRAMS Price Evaluation Adjustment for Small Disadvantaged Business Concerns 19.1104 Contract clause. Insert the clause at 52.219-23, Notice of Price Evaluation Adjustment for...

  20. 48 CFR 819.7009 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 819.7009... PROGRAMS SMALL BUSINESS PROGRAMS Service-Disabled Veteran-Owned and Veteran-Owned Small Business Acquisition Program 819.7009 Contract clauses. The contracting officer shall insert VAAR clause...

  1. 48 CFR 219.708 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... OF DEFENSE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 219.708 Contract clauses. (b)(1)(A) Use the clause at 252.219-7003, Small Business Subcontracting Plan... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clauses....

  2. 48 CFR 2103.571 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... GROUP LIFE INSURANCE FEDERAL ACQUISITION REGULATION GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Other Improper Business Practices 2103.571 Contract clause. The clause at 2152.203-70... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clause....

  3. 48 CFR 819.709 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 819.709 Contract clause. The contracting officer shall insert VAAR clause 852.219-9, Small Business Subcontracting Plan Minimum... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause....

  4. 48 CFR 803.7001 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 803.7001... BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Contractor Responsibility to Avoid Improper Business Practices 803.7001 Contract clause. The contracting officer shall insert the clause at 852.203-71,...

  5. 48 CFR 19.1308 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clauses. 19.1308... PROGRAMS SMALL BUSINESS PROGRAMS Historically Underutilized Business Zone (HUBZone) Program 19.1308 Contract clauses. (a) The contracting officer shall insert the clause 52.219-3, Notice of Total HUBZone...

  6. A new Mannich base and its transition metal (II) complexes - Synthesis, structural characterization and electrochemical study

    Indian Academy of Sciences (India)

    N Raman; S Esthar; C Thangaraja

    2004-06-01

    new Mannich base, N-(1-morpholinobenzyl) semicarbazide (MBS), formed by the condensation of morpholine, semicarbazide and benzaldehyde, and its Cu(II), Ni(II), Co(II) and Zn(II) complexes have been synthesized. Their structures have been elucidated on the basis of analytical, magnetic, electrical conductivity and spectral study as well as elemental analyses. The complexes exhibit square-planar geometry. The monomeric and non-electrolytic nature of the complexes is evidenced by their magnetic susceptibility and low conductance data. The electrochemical property of the ligand and its complexes in acetonitrile solution was studied by cyclic voltammetry. The X-band ESR spectra of the Cu(II) complex in DMSO at 300 and 77 K were recorded and their salient features are reported.

  7. Investigation of biological effects of some Mannich Bases containing Bis-1,2,4- Triazole.

    Science.gov (United States)

    Parlak, A E; Celik, S; Karatepe, M; Turkoglu, S; Alayunt, N O; Dastan, S D; Ulas, M; Sandal, S; Tekin, S; Koparir, M

    2016-01-01

    In this study, the effects of Mannich bases containing bis-1,2,4-triazole on the levels of in vivo malondialdehyde (MDA) and antioxidant vitamins (A, E, C) were examined in serum, livers and kidneys of rats. DA and vitamin (A, E, C) levels were determined by high performance liquid chromatography (HPLC). Antioxidant effect was investigated by determining the MDA levels in Saccharomyces cerevisiae cells as in vitro. Furthermore, the antitumor effects of compounds were investigated against MCF-7 human breast cancer cells. Interrelations of results among control and compound groups were evaluated using SPSS statistical software package. As a result, some of the compounds showed effective biological activity when compared to control conditions. The test compounds used in this study may be effective for utilization in the selection and design of model compounds for further studies. PMID:27453272

  8. Penalty Clauses and the CISG

    Directory of Open Access Journals (Sweden)

    Jack Graves

    2012-06-01

    Full Text Available Commercial agreements often provide for “fixed sums” payable upon a specified breach. Such agreements are generally enforced in civil law jurisdictions. In contrast, the common law distinguishes between “liquidated damages” and “penalty” clauses, enforcing the former, while invalidating the latter as a penalty. The UN Convention on Contracts for the International Sale of Goods (CISG does not directly address the payment of “fixed sums” as damages, and the validity of “penalty” clauses has, traditionally, been relegated to otherwise applicable domestic national law under CISG Article 4. This traditional orthodoxy has recently been challenged—suggesting that the fate of a penalty clause should be determined by reference to the general principles of the CISG and that such a clause should generally be enforced. The validity of fixed sums, as penalties, is currently under consideration by the CISG Advisory Council, so further exploration of the issue would seem particularly timely. This article examines the basis for the traditional view, along with two distinct challenges to that view—ultimately concluding that these challenges fail to support their respective solutions to the issue and suggesting the continuing vitality of the traditional view.

  9. Constraint Specialisation in Horn Clause Verification

    DEFF Research Database (Denmark)

    Kafle, Bishoksan; Gallagher, John Patrick

    We present a method for specialising the constraints in constrained Horn clauses with respect to a goal. We use abstract interpretation to compute a model of a query-answer transformation of a given set of clauses and a goal. The effect is to propagate the constraints from the goal top-down and...... propagate answer constraints bottom-up. Our approach does not unfold the clauses at all; we use the constraints from the model to compute a specialised version of each clause in the program. The approach is independent of the abstract domain and the constraints theory underlying the clauses. Experimental...

  10. Inhibition of Mild Steel Corrosion in 1M H2SO4 Medium by Benzimidazole Mannich bases

    Directory of Open Access Journals (Sweden)

    P. M. Dasami

    2015-03-01

    Full Text Available The corrosion inhibition behaviour of two synthesized Mannich bases has been investigated for mild steel in 1M H2SO4 by weight loss and electrochemical techniques.The inhibition efficiency depends on concentration of the inhibitor and temperature. The inhibitors function by adsorption on mild steel surface and obey Langmuir isotherm indicating monolayer adsorption on the surface. Thermodynamic parameters show that the adsorption of the inhibitors occurs through electrostatic interaction. Polarization studies reveal that the inhibitors behave as mixed type in 1M H2SO4 affecting both anodic metal dissolution and cathodic hydrogen evolution. SEM studies show the formation of surface adsorptive film of the Mannich bases on the mild steel surface.

  11. Synthesis of the reported structure of piperazirum using a nitro-Mannich reaction as the key stereochemical determining step

    Directory of Open Access Journals (Sweden)

    James C. Anderson

    2013-08-01

    Full Text Available Piperazirum, isolated from Arum palaestinum Boiss, was originally assigned as r-3,c-5-diisobutyl-c-6-isopropylpiperazin-2-one. The reported structure was synthesised diastereoselectively using a key nitro-Mannich reaction to set up the C5/C6 relative stereochemistry. The structure was unambiguously assigned by single crystal X-ray diffraction but the spectroscopic data did not match those reported for the natural product. The structure of the natural product must therefore be revised.

  12. SYNTHESIS OF BIS-PYRIMIDO IMIDAZOLE FUSED RING HETEROCYCLIC ADDUCT WITH UREAS OF MANNICH BASE FOR CNS DEPRESSION

    Directory of Open Access Journals (Sweden)

    AVANI H. SHETH*, PARIMAL M. PRAJAPATI, YATRI R. SHAH AND DHRUBO JYOTI SEN

    2009-12-01

    Full Text Available Mannich bases as well as urea derivatives have potent CNS depression activity. In our project work we have chosen aCNS drug which blocks the GABA receptor as well as chloride channel. Benzodiazepines have closed chain amidelinkage which acts on GABA (gamma amino butyric acid receptor and produces CNS depression with the blockageof chloride channel. This receptor has free amino and carboxylic acid functional group which produces amide linkagein-vivo.

  13. Accurate Reaction Enthalpies and Sources of Error in DFT Thermochemistry for Aldol, Mannich, and α-Aminoxylation Reactions

    OpenAIRE

    Wheeler, Steven E.; Moran, Antonio; Pieniazek, Susan N.; Houk, K. N.

    2009-01-01

    Enthalpies for bond-forming reactions that are subject to organocatalysis have been predicted using the high-accuracy CBS-QB3 model chemistry and six DFT functionals. Reaction enthalpies were decomposed into contributions from changes in bonding and other intramolecular effects via the hierarchy of homodesmotic reactions. The order of the reaction exothermicities (aldol < Mannich ≈ α-aminoxylation) arises primarily from changes in formal bond types mediated by contributions from secondary int...

  14. Synthesis of Arctigenin Mannich Derivative%牛蒡苷元曼尼希反应产物的合成

    Institute of Scientific and Technical Information of China (English)

    徐煜彬; 窦德强

    2013-01-01

    目的:合成牛蒡苷元曼尼希反应产物4-(3″,4″-二甲氧苄基)-3-(4′-羟基-3'-甲氧基-5′-(哌啶-1-基甲基)苯甲基)二氢呋喃-2 (3H)-酮.方法:本实验采用曼尼希的方法对牛蒡苷元酚羟基邻位进行结构修饰,牛蒡苷元与哌啶溶液反应合成曼尼希反应产物.结论:通过对合成工艺条件进行较为详细的考察,确定最佳工艺条件.%Objective:4-(3",4"-dimethoxybenzyl)-3-(4'-hydroxy-3'-methoxy-5'-(piperidin-1-ylmethyl) benzyl) dihydrofuran-2 (3H)-one,Mannich derivative of arctigenin was yielded.Method:Structure modification in phenolic hydroxyl group Ortho of arctigenin with Mannich method was carried out.The Mannich derivative was synthesized by treating arctigenin and piperidine solution.Conclusion:The art of the synthesis process was investigated in detail to determine the optimal process conditions.

  15. Identification of Mannich Base as a Novel Inhibitor of Mycobacterium Tuberculosis Isocitrate by High-Throughput Screening

    Directory of Open Access Journals (Sweden)

    Lei Ji, Quanxin Long, Dacheng Yang, Jianping Xie

    2011-01-01

    Full Text Available Mycobacterium tuberculosis (MTB remains one of the most significant human pathogens since its discovery in 1882. An estimated 1.5 million people died from tubercle bacillus (TB in 2006, and globally, there were an estimated 9.27 million incident cases of TB in 2007. Glyoxylate bypass pathway occurs in a wide range of pathogens and plays a key role in the pathogenesis of Mycobacterium tuberculosis. Isocitrate lyase (ICL can catalyses the first step of this pathway, and reversibly cleaves isocitrate into succinate and glyoxylate. So, ICL may represent a good drug target for the treatment of tuberculosis. ICL was cloned, expressed, and purified, and a high-throughput screen (HTS developed to screen active molecule from a mannich base compounds library for inhibition of ICL. This assay had signal to noise (S/N of 650.6990 and Z' factor of 0.8141, indicating that the assay was suitable for HTS. Screening of a collection of 124 mannich base compounds resulted in the identification of one mannich base compound, which has a significant inhibitory activity. So, a new family of compound was first reported to inhibit the activity of Mycobacterium tuberculosis ICL. This family of compound might offer new avenue to explore better anti-tuberculosis and fungi drugs.

  16. MD 751: Train Instability Threshold

    CERN Document Server

    Carver, Lee Robert; Metral, Elias; Salvant, Benoit; Levens, Tom; Nisbet, David; Zobov, M; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the octupole current thresholds for stability for a single bunch, and then make an immediate comparison (with the same operational settings) for a train of 72 bunches separated by 25ns. From theory, the expected thresholds should be similar. Any discrepancy between the two cases will be of great interest as it could indicate the presence of additional mechanisms that contribute to the instability threshold, for example electron cloud.

  17. 48 CFR 570.601 - FAR provisions and clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false FAR provisions and clauses... Clauses 570.601 FAR provisions and clauses. Include provisions or clauses substantially the same as the following FAR provisions and clauses. If . . . Then include . . . (a) the estimated value of the...

  18. Santa Claus, Ga./Ind.

    Science.gov (United States)

    2002-01-01

    The towns of Santa Claus, Ga., (top) and Santa Claus, Ind. (bottom), are shown in these two images from the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) instrument on NASA's Terra satellite. They are the only two Santa Claus towns in the United States with post offices and zip codes, although there are 11 towns with this name in the United States. Santa Claus, Ga. is located in Toombs County, and has a population of 237. Santa Claus, Ind. is located in Spencer County, and has a population of 2,041. Its name was accepted by the United States Postal Service in 1856. The images were acquired on July 3, 2000 (top) and June 16, 2001 (bottom), respectively.With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER images Earth to map and monitor the changing surface of our planet.ASTER is one of five Earth-observing instruments launched December 18, 1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of Economy, Trade and Industry. A joint U.S./Japan science team is responsible for validation and calibration of the instrument and the data products.The broad spectral coverage and high spectral resolution of ASTER will provide scientists in numerous disciplines with critical information for surface mapping, and monitoring of dynamic conditions and temporal change. Example applications are: monitoring glacial advances and retreats; monitoring potentially active volcanoes; identifying crop stress; determining cloud morphology and physical properties; wetlands evaluation; thermal pollution monitoring; coral reef degradation; surface temperature mapping of soils and geology; and measuring surface heat balance.Dr. Anne Kahle at NASA's Jet Propulsion Laboratory, Pasadena, Calif., is the U.S. science team leader; Bjorn Eng of JPL is the project manager. The Terra mission is part of NASA's Earth Science Enterprise, a long

  19. Revisiting Clause Exchange in Parallel SAT Solving

    OpenAIRE

    Audemard, Gilles; Hoessen, Benoît; Jabbour, Said; Lagniez, Jean-Marie; Piette, Cédric

    2012-01-01

    Managing learnt clause database is known to be a tricky task in SAT solvers. In the portfolio framework, the collaboration between threads through learnt clause exchange makes this problem even more difficult to tackle. Several techniques have been proposed in the last few years, but practical results are still in favor of very limited collaboration, or even no collaboration at all. This is mainly due to the difficulty that each thread has to manage a large amount of learnt clauses generated ...

  20. 21 CFR 26.21 - Safeguard clause.

    Science.gov (United States)

    2010-04-01

    ... OF PHARMACEUTICAL GOOD MANUFACTURING PRACTICE REPORTS, MEDICAL DEVICE QUALITY SYSTEM AUDIT REPORTS... Specific Sector Provisions for Pharmaceutical Good Manufacturing Practices § 26.21 Safeguard clause....

  1. Solving non-linear Horn clauses using a linear Horn clause solver

    DEFF Research Database (Denmark)

    Kafle, Bishoksan; Gallagher, John Patrick; Ganty, Pierre

    2016-01-01

    In this paper we show that checking satisfiability of a set of non-linear Horn clauses (also called a non-linear Horn clause program) can be achieved using a solver for linear Horn clauses. We achieve this by interleaving a program transformation with a satisfiability checker for linear Horn...

  2. Design, synthesis, and antimicrobial screening of novel pyridyl-2-amidrazone incorporated isatin mannich bases.

    Science.gov (United States)

    Kumar, N Saravana; Pradeep, T; Jani, G; Silpa, Divya; Kumar, B Vijaya

    2012-01-01

    Isatin is an endogenous compound and reported to possess a wide range of biological activities. Numerous papers have shown that the pyridyl-2-amidrazone nucleus possesses a potent antimicrobial activity. Based on these prior observations, we postulated that a compound containing both isatin and pyridyl-2-amidrazone pharmacophores could be very effective for antimicrobial activity. Unfavorable adsorption, distribution, metabolism, and excretion (ADME) properties can in many cases lead to the clinical trials failure of potentially successful drug candidates. Their evaluation, therefore, at an earlier stage is desired. Here, we also present the predicted ADME properties of our ligands through computation. All the compounds (2a(1-5)) exhibited a better solubility, diffusion, Log P, molecular weight, etc., with no violations making the ligands pharmacodynamically active and better oral absorptive series. Based on the results of computational design, a series of novel pyridyl-2-amidrazone-incorporated isatin Mannich bases were synthesized and screened for their antimicrobial activities. IR, (1)H-NMR, and Mass Spectroscopy data were consistent with the assigned structures. The results exhibited that all of the lead compounds showed good antimicrobial activities; noticeably, the compound 2a(2) showed the best activity against Candida albicans (16 μg/ml) and compound 2a(3) was found to be the most active derivative against Staphylococcus aureus and Escherichia coli at minimal inhibitory concentration values of 4 and 32 μg/ml, respectively. PMID:22470895

  3. Synthesis and Biological Evaluation of Scutellaria Flavone Cyclaneaminol Mannich Base Derivatives as Novel CDK1 Inhibitors.

    Science.gov (United States)

    Ha, Lisha; Qian, Yuan; Zhang, Shixuan; Ju, Xiulan; Sun, Shiyou; Guo, Hongmin; Wang, Qianru; Li, Kangjian; Fan, Qingyu; Zheng, Yang; Li, Hailiang

    2016-01-01

    Cyclin-dependent kinase 1 (CDK1) is the only necessary CDK in the cell proliferation process and a new target in the research and development of anti-cancer drugs. Natural flavones are selective CDK1 inhibitors which can suppress the proliferation of cancer cells. However, their bioavailability is poor. To solve these problems, 6 Scutellaria flavones were isolated from hydrolyzed products of Scutellaria baicalensis and used as lead compounds, 18 Scutellaria flavones cyclane-aminol Mannich base derivatives were semi-synthesized and their biological activity as novel CDK1 inhibitors was evaluated. Results indicated that the biological activity of 8-Hydroxypiperidinemethyl-baicalein (BA-j) is the highest among these compounds. BA-j is a selective CDK1 inhibitor, and has broad-spectrum anti-proliferative activity in human cancer cells (IC50 12.3μM). BA-j can capture oxygen free radicals (.O2(-)) and selectively increase intracellular H2O2 level in cancer cells and activated lymphocytes, thus inducing their apoptosis rather than in normal cells. These findings suggest that BA-j selectively induces apoptosis in cancer and activated lymphocyte by controlling intracellular H2O2 level, and can be developed into a novel anti-proliferative agent for the treatment of cancer, AIDS, and some immune diseases. PMID:26411959

  4. Direct Catalytic Asymmetric Mannich-Type Reaction of α- and β-Fluorinated Amides.

    Science.gov (United States)

    Brewitz, Lennart; Arteaga, Fernando Arteaga; Yin, Liang; Alagiri, Kaliyamoorthy; Kumagai, Naoya; Shibasaki, Masakatsu

    2015-12-23

    The last two decades have witnessed the emergence of direct enolization protocols providing atom-economical and operationally simple methods to use enolates for stereoselective C-C bond-forming reactions, eliminating the inherent drawback of the preformation of enolates using stoichiometric amounts of reagents. In its infancy, direct enolization relied heavily on the intrinsic acidity of the latent enolates, and the reaction scope was limited to readily enolizable ketones and aldehydes. Recent advances in this field enabled the exploitation of carboxylic acid derivatives for direct enolization, offering expeditious access to synthetically versatile chiral building blocks. Despite the growing demand for enantioenriched fluorine-containing small molecules, α- and β-fluorinated carbonyl compounds have been neglected in direct enolization chemistry because of the competing and dominating defluorination pathway. Herein we present a comprehensive study on direct and highly stereoselective Mannich-type reactions of α- and β-fluorine-functionalized 7-azaindoline amides that rely on a soft Lewis acid/hard Brønsted base cooperative catalytic system to guarantee an efficient enolization while suppressing undesired defluorination. This protocol contributes to provide a series of fluorinated analogs of enantioenriched β-amino acids for medicinal chemistry. PMID:26652911

  5. Claus moleculars del plegament oxidatiu

    OpenAIRE

    Ventura Zamora, Salvador

    2006-01-01

    Després de ser sintetitzades, les proteïnes es plegan per adquirir la seva funció. Encara que aquest procés, anomenat plegament oxidatiu, ha estat investigat en profunditat, s'havien descurat aspectes claus com són la termodinàmica o la predicció computacional. Investigadors de la UAB van desmuntar aquest puzle i de les seves conclusions es desprèn una teoria que unifica els estudis de plegament oxidatiu realitzats fins al moment.

  6. Santa Claus ’Names

    Institute of Scientific and Technical Information of China (English)

    寒冰

    2005-01-01

    A ustria—Christkind Belgium and the N etherlands—N oel Saint Nicholas C hristkind and Black Pete Brazil—Papa;N oel D enm ark—Julinisse England—Father Christm as Finland—O ld M an C hristm asFrance—Pere N oel or le Petit Germ any—K riss Kringle Christkind or Saint N icholas Italy—B efana Japan—Santa K urohsu M exico—Three Kings Poland—Star M an or W ise M en Spain—Three Kings R ussia—B asbouschka ?Santa Claus ’Names@寒冰

  7. 48 CFR 732.111 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 732.111... CONTRACTING REQUIREMENTS CONTRACT FINANCING General 732.111 Contract clauses. (a) (b) USAID may obtain short... indefinite quantity contracts that are a combination of contract types. Rather than using the...

  8. 48 CFR 716.406 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 716.406 Section 716.406 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost Reimbursement Contracts 716.406 Contract clauses....

  9. 48 CFR 1443.205 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1443.205 Section 1443.205 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 1443.205 Contract clauses. BPCs may establish procedures,...

  10. 48 CFR 916.307 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 916.307 Section 916.307 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 916.307 Contract clauses. (g) Insert...

  11. 48 CFR 908.1104 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... leased over 60 days, except for those vehicles exempted by (FPMR) 41 CFR 101-38.6. ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 908.1104... PLANNING REQUIRED SOURCES OF SUPPLIES AND SERVICES Leasing of Motor Vehicles 908.1104 Contract clauses....

  12. 48 CFR 1333.215 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1333.215 Section 1333.215 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE GENERAL CONTRACTING REQUIREMENTS PROTESTS, DISPUTES, AND APPEALS Disputes and Appeals 1333.215 Contract clauses. Alternate I of...

  13. 48 CFR 1433.215 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1433.215 Section 1433.215 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR GENERAL CONTRACTING REQUIREMENTS PROTESTS, DISPUTES, AND APPEALS Disputes and Appeals 1433.215 Contract clauses. The...

  14. 48 CFR 1345.107 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1345.107 Section 1345.107 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 1345.107 Contract clauses....

  15. 48 CFR 1416.405 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1416.405 Section 1416.405 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 1416.405 Contract clauses. The BPC, without the...

  16. 48 CFR 23.1005 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Federal Compliance With Right-To-Know Laws and Pollution Prevention Requirements 23.1005 Contract clause. (a) Insert the clause at 52.223-5, Pollution Prevention and...

  17. 48 CFR 811.404 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 811.404... ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Delivery or Performance Schedules 811.404 Contract clause. When delivery is required by or on a particular date for f.o.b. destination contracts, the contracting...

  18. 48 CFR 704.404 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 704.404... ADMINISTRATIVE MATTERS Safeguarding Classified Information Within Industry 704.404 Contract clause. If the contract involves access to classified (“Confidential”, “Secret”, or “Top Secret”), or...

  19. 48 CFR 833.215 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 833.215 Section 833.215 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL CONTRACTING REQUIREMENTS PROTESTS, DISPUTES, AND APPEALS Disputes and Appeals 833.215 Contract clause. The...

  20. 48 CFR 923.7003 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... contractor and subcontractor employees at such facility, the clause at 952.223-71, Integration of Environment... services; and (3) The facility is government-owned, or leased by or for the account of the government. (c... clause found at 952.223-71, Integration of Environment, Safety, and Health into Work Planning...

  1. 48 CFR 232.7004 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Electronic Submission and Processing of Payment Requests and Receiving Reports 232.7004 Contract clause. Except as provided in 232.7002(a... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clause....

  2. 48 CFR 532.908 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract clauses. 532.908... REQUIREMENTS CONTRACT FINANCING Prompt Payment 532.908 Contract clauses. (a) GSA has a FAR deviation that... Information for Electronic Funds Transfer Payment; and (iii) For which the order is placed, and the...

  3. 48 CFR 538.273 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract clauses. 538.273... Schedules 538.273 Contract clauses. (a) Multiple award schedules. Insert in solicitations and contracts: (1) 552.238-70, Identification of Electronic Office Equipment Providing Accessibility for the...

  4. 24 CFR 221.1 - Savings clause.

    Science.gov (United States)

    2010-04-01

    ... MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES LOW COST AND MODERATE INCOME MORTGAGE INSURANCE-SAVINGS CLAUSE Eligibility Requirements-Low Cost Homes-Savings Clause § 221.1...) of the National Housing Act (12 U.S.C. 1715l(d)(2)) for low cost and moderate income...

  5. 48 CFR 937.7040 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... CONTRACTING SERVICE CONTRACTING Protective Services Contracting 937.7040 Contract clauses. The contracting officer shall insert the clause at 952.237-70 entitled “Collective bargaining agreements—protective services” in all protective services solicitations and contracts involving DOE-owned facilities...

  6. 48 CFR 519.708 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract clauses. 519.708 Section 519.708 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 519.708 Contract clauses....

  7. 48 CFR 1019.708 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1019.708 Section 1019.708 Federal Acquisition Regulations System DEPARTMENT OF THE TREASURY SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 1019.708 Contract clauses....

  8. 48 CFR 19.708 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 19.708 Contract clauses. (a... affecting section 19.708, see the List of CFR Sections Affected, which appears in the Finding Aids section... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clauses....

  9. 48 CFR 32.412 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clause. 32.412 Section 32.412 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING... rapid liquidation appropriate, the contracting officer shall use the clause with its Alternate III....

  10. 48 CFR 222.7404 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... on the Use of Mandatory Arbitration Agreements 222.7404 Contract clause. Use the clause at 252.222-7006 Restrictions on the Use of Mandatory Arbitration Agreements, in all solicitations and contracts... commercial items, including commercially available off-the-shelf items....

  11. 48 CFR 23.602 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clause. 23.602... DRUG-FREE WORKPLACE Notice of Radioactive Material 23.602 Contract clause. The contracting officer..., aircraft, ammunition, missiles, vehicles, electronic tubes, instrument panel gauges, compasses...

  12. 48 CFR 503.1004 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract clauses. 503.1004 Section 503.1004 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Contractor Code of Business Ethics and Conduct 503.1004 Contract clauses. (a) The...

  13. Cavity Voltage Phase Modulation MD

    CERN Document Server

    Mastoridis, T; Butterworth, A; Molendijk, J; Tuckmantel, J

    2012-01-01

    The LHC RF/LLRF system is currently setup for extremely stable RF voltage to minimize transient beam loading eects. The present scheme cannot be extended beyond nominal beam current since the demanded power would push the klystrons to saturation. For beam currents above nominal (and possibly earlier), the cavity phase modulation by the beam will be not be corrected (transient beam loading), but the strong RF feedback and One-Turn Delay feedback will still be active for loop and beam stability in physics. To achieve this, the voltage set point will be adapted for each bunch. The goal of this MD was to test an iterative algorithm that would adjust the voltage set point to achieve the optimal phase modulation for klystron forward power considerations.

  14. Antitumor Effect of the Mannich Base(1,3-bis-((3-Hydroxynaphthalen-2-yl)phenylmethyl)urea) on Hepatocellular Carcinoma

    OpenAIRE

    Vadanasundari Vedarethinam; Karthik Dhanaraj; Soundharrajan Ilavenil; Mariadhas Valan Arasu; Ki Choon Choi; Naif Abdullah Al-Dhabi; Srigopalram Srisesharam; Kyung Dong Lee; Da Hye Kim; Tamilvenvendan Dhanapal; Ravikumar Sivanesan; Han Sung Choi; Young Ock Kim

    2016-01-01

    The present study was designed to evaluate the antitumor effects of the synthetic Mannich base 1,3-bis-((3-hydroxynaphthalen-2-yl)phenylmethyl)urea (1,3-BPMU) against HEP-G2 hepatoma cells and diethylnitrosamine (DEN)-induced hepatocarcinoma (HCC) in albino rats. In vitro analysis results revealed that 1,3-BPMU showed significant cytotoxicity and cell growth inhibition in HEP-G2 hepatoma cells in a concentration-dependent manner. Furthermore, flow cytometry results indicated that 1,3-BPMU enh...

  15. In Vitro Antioxidant Evaluation of Some Mannich Bases which Contain Bis-1,2,4 -Triazole Derivative

    International Nuclear Information System (INIS)

    This study aims to examine the antioxidant effects of some Mannich bases containing bis-1, 2, 4 triazole, which are synthesized afresh. The antioxidant activities of the derivatives were measured using different methods in this study, including reducing power capacity, metal chelating activity, superoxide anion radicals scavenging activity, H/sub 2/ O/sub 2/ scavenging activity and hydroxyl radical scavenging. As a result, derivatives had efficient antioxidant and free radical scavenging activity when compared to ascorbic acid, BHT and alpha-tocopherol as associated antioxidants. (author)

  16. Synthesis of New Salen Ligands by Mannich Reaction%由Mannich反应合成新型Salen配体

    Institute of Scientific and Technical Information of China (English)

    王暖升; 李俊英; 李天铎

    2012-01-01

    以乙二胺或乙二胺衍生物为碱,与甲醛、对甲酚通过Mannich反应生成了四种N,N′-双(水杨醛)乙二胺(salen)配体,其中3个为新化合物.其结构经1H NMR,IR,MS和元素分析表征.%Four Salen ligangds(three of them are novel) were synthesized by Mannich condensation of ethanediamine or ethylenediamine derivatives with formaldehyde and p-cresol. The structures were characterized by 'H NMR, IR, MS and elemental analysis.

  17. A tandem Mannich addition–palladium catalyzed ring-closing route toward 4-substituted-3(2H-furanones

    Directory of Open Access Journals (Sweden)

    Jubi John

    2014-06-01

    Full Text Available A facile route towards highly functionalized 3(2H-furanones via a sequential Mannich addition–palladium catalyzed ring closing has been elaborated. The reaction of 4-chloroacetoacetate esters with imines derived from aliphatic and aromatic aldehydes under palladium catalysis afforded 4-substituted furanones in good to excellent yields. 4-Hydrazino-3(2H-furanones could also be synthesized from diazo esters in excellent yields by utilising the developed strategy. We could also efficiently transform the substituted furanones to aza-prostaglandin analogues.

  18. 2-methyl-3-butyn-2-ol as an acetylene precursor in the Mannich reaction. A new synthesis of suicide inactivators of monoamine oxidase

    International Nuclear Information System (INIS)

    A two-step reaction process is reported for the synthesis of 11C, 13C, or 14C-labelled propargylamines in moderate yields. The propargylamines were prepared by a modified Mannich scheme without the use of acetylene. The reaction scheme involved the use of 2-methyl-3-butyn-2-ol followed by KOH-catalyzed elimination of acetone from the acetylenic carbinols

  19. Synthesis of mono Mannich bases of 2-(4-hydroxybenzylidene)-2,3-dihydroinden-1-one and evaluation of their cytotoxicities.

    Science.gov (United States)

    Tugrak, Mehtap; Yamali, Cem; Sakagami, Hiroshi; Gul, Halise Inci

    2016-10-01

    Chalcones and Mannich bases are a group of compounds known for their cytotoxicities. In this study restricted chalcone analogue, compound 2-(4-hydroxybenzylidene)-2,3-dihydroinden-1-one MT1, was used as a starting compound to synthesize new mono Mannich bases since Mannich bases may induce more cytotoxicity than chalcone analogue that they are derived from by producing additional alkylating center for cellular thiols. In this study, cyclic and acyclic amines were used to synthesize Mannich bases. All compounds were tested against Ca9-22 (gingival carcinoma), HSC-2, HSC-3 and HSC-4 (oral squamous cell carcinoma) as tumour cell lines and HGF (gingival fibroblasts), HPC (pulp cells) and HPLF (periodontal ligament fibroblasts) human normal oral cells as non tumour cell lines. Cytotoxicity, selectivity index (SI) values and potency selectivity expression (PSE) values expressed as a percentage were determined for the compounds. According to data obtained, the compound MT8 with the highest PSE value bearing N-methylpiperazine moiety seems to be a good candidate to develop new cytotoxic compounds and is suited for further investigation. PMID:26247355

  20. Harvesting graphics power for MD simulations

    NARCIS (Netherlands)

    J.A. van Meel; A. Arnold; D. Frenkel; S.F. Portegies Zwart; R.G. Belleman

    2008-01-01

    We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a congruentia

  1. Fast Collision Attack on MD5

    NARCIS (Netherlands)

    Stevens, M.M.J.

    2006-01-01

    In this paper, we present an improved attack algorithm to find two-block collisions of the hash function MD5. The attack uses the same differential path of MD5 and the set of sufficient conditions that was presented by Wang et al. We present a new technique which allows us to deterministically fulfi

  2. Advances in Delta-md measurements

    OpenAIRE

    Ronga, Frederic Jean

    2003-01-01

    We report the current status of Delta-md measurements at B-factories. The most recent world average is Delta-md = 0.502+-0.007 1/ps (1.4% accuracy). An estimate of the errors for 500 1/fb data is also given.

  3. The Information Structure of Adverbial Clauses in Chinese Discourse

    OpenAIRE

    Yu-Fang Wang

    2006-01-01

    This study investigated adverbial clauses in spoken as well as written Chinese discourse. The adverbial clauses in the spoken data were categorized into (i) initial clauses that occur in the initial position with respect to their linked material across continuing intonation, (ii) final clauses that occur in the final position with respect to their linked material across continuing intonation, and (iii) final clauses that occur in the final position with respect to their linked material across...

  4. PENALTY CLAUSES WITHIN DIFFERENT LEGAL SYSTEMS

    Directory of Open Access Journals (Sweden)

    Simas Vitkus

    2013-06-01

    Full Text Available In this article the regulation in regard of penalty clauses within two different legal traditions, i.e. common law tradition and continental law tradition, is analyzed. In general a penalty clause implies a fixed sum, which has to be paid by a party for the failure to perform its contractual duties timely and duly. In common law world penalty clauses are rendered unenforceable, whereas civil law countries, including the Republic of Lithuania, consider such clauses enforceable to the extent that the stipulated amount is not excessive. Moreover, in the article attempts to reach a uniform regulation throughout various legal instruments are revealed. Purpose: to analyze the regulation of penalty clauses within different legal systems. Methodology: a systematic method was used in order to ascertain the content and true meaning of the legislation concerning penalty clauses, whereas comparative method allowed comparing such legislation among different jurisdictions. On the basis of analytical method conclusions were withdrawn. Findings: common law courts on the basis of just compensation principle may declare a clause, which stands for a penalty, unenforceable, whereas civil law courts may only reduce grossly excessive amount. However, under major soft law instruments, such as the UNIDROIT Principles , PECL and DCRF , the divergence from common law rules of non-enforcement of penalty clauses is evident. Although there is a lack of binding transnational rules that control the enforceability of penalty clauses across the countries, it seems that today the most feasible solution consists of the approval of national rules, which would shield the enforcement of penalties in international commercial contracts in common law jurisdictions. Research limitations: in the light of the civil law system terms of liquidated damages and penalty clause are used interchangeably, since both are enforceable. However, a distinction between the two can be made on the basis

  5. 48 CFR 2432.908 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... commercial services awarded pursuant to FAR part 12. (2) The Contracting Officer shall insert a clause...-reimbursement type solicitations and contracts when vouchers are to be sent directly to the paying office....

  6. The Information Structure of Adverbial Clauses in Chinese Discourse

    Directory of Open Access Journals (Sweden)

    Yu-Fang Wang

    2006-06-01

    Full Text Available This study investigated adverbial clauses in spoken as well as written Chinese discourse. The adverbial clauses in the spoken data were categorized into (i initial clauses that occur in the initial position with respect to their linked material across continuing intonation, (ii final clauses that occur in the final position with respect to their linked material across continuing intonation, and (iii final clauses that occur in the final position with respect to their linked material across final intonation. Those in the written data were classified into (i initial and (ii final clauses that occur in the initial or final clauses that occur in the initial or final position, respectively, with respect to their main clauses. An analysis of the spoken and written data shows that the temporal, conditional, and concessiveclauses are quite different from the other adverbial clauses. Specifically, the causal clauses commonly appear in the final position with respect to their associated material in the spoken data, while the initial and final causal clauses are nearly evenly distributed in the written data. The data suggest that temporal, conditional, and concessive clauses, like topics, are presupposed parts of their sentences; i.e., all of them may be thought of as establishing frameworks for the interpretation of propositions that follow, which seem to be prototypically textual in their functioning. By contrast, causal clauses in Chinese are noticeably distinct from other adverbial clauses not only in spoken data, but also in written data; they play interactional as well as textual roles in discourse linking.

  7. Multi-Dimensional Games (MD-Games)

    OpenAIRE

    Ruiz Estrada, M.A.

    2009-01-01

    This paper introduces the concept of Multi-Dimensional games (MD-games) based on the application of an alternative mathematical and graphical modeling approach to study the game theory from a multi-dimensional perspective. In fact, the MD-Games request the application of the mega-space coordinate system to visualize a large number of games, players, strategies and pay-offs functions into the same graphical space.

  8. Antimicrobial and hypoglycemic activities of novel N-Mannich bases derived from 5-(1-adamantyl)-4-substituted-1,2,4-triazoline-3-thiones.

    Science.gov (United States)

    Al-Abdullah, Ebtehal S; Al-Tuwaijri, Hanaa M; Hassan, Hanan M; Haiba, Mogedda E; Habib, Elsayed E; El-Emam, Ali A

    2014-01-01

    The reaction of 5-(1-adamantyl)-4-ethyl or allyl-1,2,4-triazoline-3-thione with formaldehyde solution and various 1-substituted piperazines yielded the corresponding N-Mannich bases. The newly synthesized N-Mannich bases were tested for in vitro inhibitory activities against a panel of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. Six compounds showed potent antibacterial activity against one or more of the tested microorganisms, while two compounds exhibited moderate activity against the tested Gram-positive bacteria. None of the newly synthesized compounds were proved to possess marked activity against Candida albicans. The oral hypoglycemic activity of six compounds was determined in streptozotocin (STZ)-induced diabetic rats. Four compounds produced significant strong dose-dependent reduction of serum glucose levels, compared to gliclazide at 10 mg/kg dose level (potency ratio > 75%). PMID:25514407

  9. Antimicrobial and Hypoglycemic Activities of Novel N-Mannich Bases Derived from 5-(1-Adamantyl-4-substituted-1,2,4-triazoline-3-thiones

    Directory of Open Access Journals (Sweden)

    Ebtehal S. Al-Abdullah

    2014-12-01

    Full Text Available The reaction of 5-(1-adamantyl-4-ethyl or allyl-1,2,4-triazoline-3-thione with formaldehyde solution and various 1-substituted piperazines yielded the corresponding N-Mannich bases. The newly synthesized N-Mannich bases were tested for in vitro inhibitory activities against a panel of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. Six compounds showed potent antibacterial activity against one or more of the tested microorganisms, while two compounds exhibited moderate activity against the tested Gram-positive bacteria. None of the newly synthesized compounds were proved to possess marked activity against Candida albicans. The oral hypoglycemic activity of six compounds was determined in streptozotocin (STZ-induced diabetic rats. Four compounds produced significant strong dose-dependent reduction of serum glucose levels, compared to gliclazide at 10 mg/kg dose level (potency ratio > 75%.

  10. MD5算法的分析和改进%Analysis and Improvement of .MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    么丽颖

    2011-01-01

    首先研究了MD5算法,并总结了MD5算法的特点及性能,在研究MD5算法的基础之上,提出了MD5改进加密算法.最后,对MD5算法与MD5改进算法对应于相关数据、性能进行了比较.%At first , MD5 algorithm is researched, and the characteristic and capability of the MD5 are summaried in the paper. The improved MD5 algorithm is put forward based on the research of the MDS. At last, the contrast between MD5 algorithm and the improved MD5 algorithm in related datum and capability are put forward.

  11. CLAUSE AS THE TRANSLATION UNIT IN CHINESE TO ENGLISH TRANSLATION

    Institute of Scientific and Technical Information of China (English)

    向阳

    2001-01-01

    On the basis of Halliday' s theory, this paper makes it clear that clause as the translation unit is operational in Chinese to English translation and expounds the application of clause as the translation unit with some examples.

  12. Efficient synthesis and antimicrobial evaluation of some Mannich bases from 2-arylidine-1-thia-4-azaspiro[4.5]decan-3-ones

    OpenAIRE

    Essam M. Hussein; Masaret, Ghada S; Khairou, Khalid S

    2015-01-01

    Background Thiazolidinone, has been employed in the preparation of different important drugs required for treatment of inflammations, bacterial infections, and hypertension. Mannich bases have been shown to exhibit diverse biological activities, such as antibacterial, and antifungal activities. Spiroheterocycles including thiazolidine moiety have antimicrobial activity. Results In this study, a novel, rapid, and efficient protocol is developed for the synthesis of various 2-arylidine-1-thia-4...

  13. Direct carbon-carbon bond formation via reductive soft enolization: a syn-selective Mannich addition of α-iodo thioesters.

    Science.gov (United States)

    Truong, Ngoc; Sauer, Scott J; Seraphin-Hatcher, Cyndie; Coltart, Don M

    2016-08-16

    The β-amino carboxylic acid moiety is a key feature of numerous important biologically active compounds. We describe a syn-selective direct Mannich addition reaction that uses α-iodo thioesters and sulfonyl imines and produces β-amino thioesters. Enolate formation is achieved by reductive soft enolization. The products of the reaction provide straightforward access to biologically important β-lactams through a variety of known reactions. PMID:27492274

  14. Institute Cargo Clauses : Nova verzija 2009.

    OpenAIRE

    Lovrić, Ivana

    2012-01-01

    Institute Cargo Clauses, 2009. znače izmijenjene i dopunjene Institute Cargo Clauses iz 1982. Osnovni razlozi za reviziju prijašnjih uvjeta leže u pojavi novih rizika, potrebi da se uvjeti kargo osiguranja prilagode promjenama u suvremenom transportnom sustavu te jezično i terminološki osuvremene. Novi uvjeti donose niz rješenja koja znače modernizaciju u odnosu na rješenja Marine Insurance Acta iz 1906. Redaktori novih uvjeta vodili su računa i o tome da pojedine odredbe budu jasnije form...

  15. Trajanje osiguranja prema Institute Cargo Clauses (2009.)

    OpenAIRE

    Petrinović, Ranka; Lovrić, Ivana

    2012-01-01

    Institute Cargo Clauses iz 2009. zapravo su izmjene i dopune Institute Cargo Clauses iz 1982. Osnovni su razlozi za reviziju prijašnjih uvjeta u pojavi novih rizika, potrebi da se uvjeti kargo-osiguranja prilagode promjenama u suvremenome transportnom sustavu te jezično i terminološki osuvremene. Novi uvjeti donose više rješenja koja znače modernizaciju u usporedbi s onima u Marine Insurance Acta iz 1906., pa se prezentiraju kao klauzule za novo tisućljeće. Među bitnim promjenama koje donose ...

  16. 48 CFR 3447.7000 - Foreign travel clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Foreign travel clause... REGULATION CONTRACT MANAGEMENT TRANSPORTATION Foreign Travel 3447.7000 Foreign travel clause. The contracting officer shall insert the clause in 3452.247-70, Foreign Travel, in all solicitations and resultant...

  17. 48 CFR 1401.670-1 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 1401.670... DEPARTMENT OF THE INTERIOR ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and Responsibilities 1401.670-1 Contract clause. Insert the clause at 1452.201-70 in solicitations and contracts...

  18. 48 CFR 909.507-2 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 909.507-2... PLANNING CONTRACTOR QUALIFICATIONS Organizational and Consultant Conflicts of Interest 909.507-2 Contract clause. (a)(1) The contracting officer shall insert the clause at 952.209-72, Organizational Conflicts...

  19. 48 CFR 870.111-3 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 870.111... SUPPLEMENTARY REGULATIONS SPECIAL PROCUREMENT CONTROLS Controls 870.111-3 Contract clauses. (a) The contracting... contracts for bread and bakery products. (b) The contracting officer shall include the clause at...

  20. 48 CFR 41.501 - Solicitation provision and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... contract clauses. 41.501 Section 41.501 Federal Acquisition Regulations System FEDERAL ACQUISITION... Contract Clauses 41.501 Solicitation provision and contract clauses. (a) Because the terms and conditions... substantially the same as the provision at 52.241-1, Electric Service Territory Compliance Representation,...

  1. 48 CFR 232.1110 - Solicitation provision and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... contract clauses. 232.1110 Section 232.1110 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Electronic Funds Transfer 232.1110 Solicitation provision and contract clauses. Use the clause at 252.232-7009,...

  2. 48 CFR 2832.1110 - Solicitation provision and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... contract clauses. 2832.1110 Section 2832.1110 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE General Contracting Requirements CONTRACT FINANCING Electronic Funds Transfer 2832.1110 Solicitation provision and contract clauses. When the clause at FAR 52.232-34, Payment by Electronic Funds...

  3. 48 CFR 3009.507-2 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... Organizational and Consultant Conflicts of Interest 3009.507-2 Contract clause. The contracting officer shall insert a clause substantially the same as the clause at (HSAR) 48 CFR 3052.209-73, Limitation of Future Contracting, in solicitations and contracts when a potential organizational conflict of interest exists...

  4. 48 CFR 229.402-70 - Additional clauses.

    Science.gov (United States)

    2010-10-01

    ... performance will be in Spain. (f) Use the clause at 252.229-7006, Value Added Tax Exclusion (United Kingdom.... (i) Use the clause at 252.229-7009, Relief from Customs Duty and Value Added Tax on Fuel (Passenger... SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS TAXES Contract Clauses...

  5. 48 CFR 970.0370-2 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 970.0370... SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Improper Business Practices and Personal Conflicts of Interest 970.0370-2 Contract clause. (a) The contracting officer shall insert the clause at...

  6. 48 CFR 619.811-3 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract clauses. 619.811... PROGRAMS SMALL BUSINESS PROGRAMS Contracting with the Small Business Administration (The 8(a) Program) 619.811-3 Contract clauses. (d) The contracting officer shall insert the clause at FAR...

  7. 48 CFR 519.870-8 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract clauses. 519.870... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (The 8(a) Program) 519.870-8 Contract clauses. (a) Insert the following clauses in solicitations, contracts,...

  8. 48 CFR 1403.570-3 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 1403.570... IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Other Improper Business Practices 1403.570-3 Contract clause. CO's shall include the clause at 1452.203-70, Restriction on Endorsements, in...

  9. 48 CFR 203.570-3 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF DEFENSE GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Other Improper Business Practices 203.570-3 Contract clause. Use the clause at 252.203-7001, Prohibition on Persons... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clause....

  10. 48 CFR 1319.811-3 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1319.811... PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (the 8(a) Program) 1319.811-3 Contract clauses. (a) The contracting officer shall insert the clause 1352.219-70, Section...

  11. 48 CFR 970.0371-9 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 970.0371... SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Improper Business Practices and Personal Conflicts of Interest 970.0371-9 Contract clause. The contracting officer shall insert the clause at...

  12. 48 CFR 19.811-3 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clauses. 19.811-3... PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (the 8(a) Program) 19.811-3 Contract clauses. (a) The contracting officer shall insert the clause at 52.219-11, Special...

  13. 48 CFR 219.811-3 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clauses. 219.811..., DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (The 8(a) Program) 219.811-3 Contract clauses. (1) Use the clause at 252.219-7009, Section...

  14. 48 CFR 52.102 - Incorporating provisions and clauses.

    Science.gov (United States)

    2010-10-01

    ... REGULATION (CONTINUED) CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Instructions for Using... clause that can be accessed electronically by the offeror or prospective contractor may be incorporated... contracting officer includes in the solicitation and contract a statement that— (1) Identifies all...

  15. Semantic Bias in the Acquisition of Relative Clauses in Japanese

    Science.gov (United States)

    Ozeki, Hiromi; Shirai, Yasuhiro

    2010-01-01

    This study analyzes the acquisition of relative clauses in Japanese to determine the semantic and functional characteristics of children's relative clauses in spontaneous speech. Longitudinal data from five Japanese children are analyzed and compared with English data (Diessel & Tomasello, 2000). The results show that the relative clauses produced…

  16. 48 CFR 1852.227-84 - Patent rights clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Patent rights clauses. 1852... 1852.227-84 Patent rights clauses. The contracting officer shall insert the following provision as prescribed in 1827.303-70(e): Patent Rights Clauses (DEC 1989) This solicitation contains the patent...

  17. Fast Collision Attack on MD5

    OpenAIRE

    Stevens, Marc

    2006-01-01

    In this paper, we present an improved attack algorithm to find two-block collisions of the hash function MD5. The attack uses the same differential path of MD5 and the set of sufficient conditions that was presented by Wang et al. We present a new technique which allows us to deterministically fulfill restrictions to properly rotate the differentials in the first round. We will present a new algorithm to find the first block and we will use an algorithm of Klima to find the second block. To o...

  18. Harvesting graphics power for MD simulations

    OpenAIRE

    Meel, van, C.S.; Arnold, A; Frenkel, D.; Portegies Zwart, S.F.; Belleman, R.G.

    2008-01-01

    We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a congruential shift random number generator are presented. The performance of the GPU’s is compared to their main processor counterpart. We achieve speedups of up to 40, 80 and 150 fold, respectively. With the...

  19. Harvesting graphics power for MD simulations

    OpenAIRE

    2008-01-01

    Abstract We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a congruential shift random number generator are presented. The performance of the GPU's is compared to their main processor counterpart. We achieve speedups of up to 80, 40 and 150 fold, re...

  20. ProtoMD: A Prototyping Toolkit for Multiscale Molecular Dynamics

    OpenAIRE

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2013-01-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates `GROMACS wrapper' to initiate MD simula...

  1. 48 CFR 747.507 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... (48 CFR) FAR 52.247-64 as prescribed in (48 CFR) FAR 27.507(a) in other situations. ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 747.507 Section 747.507 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT...

  2. 48 CFR 745.106 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... required in (48 CFR) FAR 45.106 in all contracts under which the contractor will acquire property with... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 745.106 Section 745.106 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT...

  3. 48 CFR 1336.609 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1336.609 Section 1336.609 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Architect-Engineer Services 1336.609...

  4. 48 CFR 1424.104 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1424.104 Section 1424.104 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR SOCIOECONOMIC PROGRAMS PROTECTION OF PRIVACY AND FREEDOM OF INFORMATION Protection of Individual Privacy 1424.104 Contract...

  5. 48 CFR 1427.303 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1427.303 Section 1427.303 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights Under Government Contracts. 1427.303 Contract...

  6. 48 CFR 811.107 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 811.107 Section 811.107 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS COMPETITION AND ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Selecting and Developing Requirements Documents 811.107...

  7. 48 CFR 811.204 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 811.204 Section 811.204 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS COMPETITION AND ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Using and Maintaining Requirements Documents 811.204...

  8. 48 CFR 1808.870 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clause. 1808.870 Section 1808.870 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION COMPETITION AND ACQUISITION PLANNING REQUIRED SOURCES OF SUPPLIES AND SERVICES Acquisition of Printing and Related Supplies 1808.870 Contract...

  9. Licensing Revisited: Open Access Clauses in Practice

    Directory of Open Access Journals (Sweden)

    Birgit Schmidt

    2012-11-01

    Full Text Available Open access increases the visibility and use of research outputs and promises to maximize the return on our public investment in research. However, only a minority of researchers will "spontaneously" deposit their articles into an open access repository. Even with the growing number of institutional and funding agency mandates requiring the deposit of papers into the university repository, deposit rates have remained stubbornly low. As a result, the responsibility for populating repositories often falls onto the shoulders of library staff and/or repository managers. Populating repositories in this way – which involves obtaining the articles, checking the rights, and depositing articles into the repository – is time consuming and resource intensive work.The Confederation of Open Access Repositories (COAR, a global association of repository initiatives and networks, is promoting a new strategy for addressing some of the barriers to populating repositories, involving the use of open access archiving clauses in publisher licenses. These types of clauses are being considered by consortia and licensing agencies around the world as a way of ensuring that all the papers published by a given publisher are cleared for deposit into the institutional repository. This paper presents some use cases of open access archiving clauses, discusses the major barriers to implementing archiving language into licenses, and describes some strategies that organizations can adopt in order to include such clauses into publisher licenses.

  10. 48 CFR 22.202 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clause. 22.202 Section 22.202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC... employment of convict labor; (b) The supplies or services are to be purchased from Federal Prison...

  11. 48 CFR 1632.772 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clause. 1632.772 Section 1632.772 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING...

  12. 48 CFR 927.303 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... is a domestic small business or nonprofit organization as defined at (FAR) 48 CFR 27.301, except... (but see (FAR) 48 CFR 27.304-3 regarding contracts for construction work or architect-engineer services... use the clause at (FAR) 48 CFR 52.227-12 except in situations where patent counsel grants a...

  13. 48 CFR 1403.1004 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 1403.1004 Section 1403.1004 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Contractor Code of Business Ethics and Conduct...

  14. 48 CFR 203.1004 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clauses. 203.1004 Section 203.1004 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Contractor Code of Business Ethics and Conduct...

  15. The occupational health of Santa Claus

    OpenAIRE

    Straube, Sebastian; Fan, Xiangning

    2015-01-01

    Previous publications in the field of Santa studies have not focused on health and safety issues arising from Santa’s workplace activities. However, it should be acknowledged that unique occupational hazards exist for Santa Claus. Major occupational health issues affecting Santa are discussed, along with suggestions for future research directions.

  16. 78 FR 2707 - Maryland Disaster # MD-00026

    Science.gov (United States)

    2013-01-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Maryland Disaster MD-00026 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... INFORMATION CONTACT: A. Escobar, Office of Disaster Assistance, U.S. Small Business Administration, 409...

  17. Novel aminonaphthoquinone mannich bases derived from lawsone and their copper(II) complexes: synthesis, characterization and antibacterial activity

    Energy Technology Data Exchange (ETDEWEB)

    Neves, Amanda P.; Barbosa, Claudia C.; Greco, Sandro J.; Vargas, Maria D. [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Inst. de Quimica; Visentin, Lorenzo C. [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Inst. de Quimica; Pinheiro, Carlos B. [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Dept. de Fisica; Mangrich, Antonio S. [Universidade Federal do Parana (UFPR), Curitiba, PR (Brazil). Centro Politecnico. Dept. de Quimica; Barbosa, Jussara P.; Costa, Gisela L. da [Instituto Oswaldo Cruz, Rio de Janeiro, RJ (Brazil)

    2009-07-01

    A series of novel Mannich bases (HL1-HL13) derived from 2-hydroxy-1,4-naphthoquinone (lawsone), substituted benzaldehydes [C{sub 6}H{sub 2}R{sup 1}R{sup 2}R{sup 3}C(O)H] and various primary amines (NH{sub 2}R{sup 4}, R{sup 4} = n-butyl, benzyl, allyl, 2-furfuryl), and their Cu{sup 2+} complexes, [Cu(L1){sub 2}]-[Cu(L13){sub 2}], have been synthesized and fully characterized by analytical and spectroscopic methods. The structures of complexes 1 (R{sup 1} R{sup 2} = R{sup 3} = H; R{sup 4} = Bu), 2 (R{sup 1} = R{sup 3} = H; R{sup 2} = NO{sub 2}; R{sup 4}= Bu) and 7 (R{sup 1} OH; R{sup 2} = R{sup 3} = H; R{sup 4}= Bu) were determined by single crystal X-ray diffraction studies. All complexes crystallize in centrosymmetric space groups, with a copper atom in the inversion centre. Two L. coordinate through the naphthalen-2-olate oxygen and secondary amine-N atoms, forming six membered chelate rings around the copper atom in a trans-N{sub 2}O{sub 2} environment; spectroscopic data confirm that the other complexes exhibit similar molecular arrangement. The antimicrobial activity of all compounds has been tested on seven different strains of bacteria: Bacillus cereus, Bacillus subtilis, Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae, Pseudomonas aeruginosa and Staphylococcus aureus. In general, Mannich bases were more active than complexes, HL11 (R{sup 1} = OH; R{sup 2} =H; R{sup 3} = Me; R{sup 4}= Bn) and HL13 (R{sup 1} = OH; R{sup 2} = H; R{sup 3} = Br; R{sup 4}= Bn) being the most potent inhibitors. The MIC for the most active compound HL11 against S. Coli was 20 {mu}mol L{sup -1} (8 {mu}g mL{sup -1}), better than Chloramphenicol (90 {mu}mol L{sup -1}) and well below most values reported for other naphthoquinones. (author)

  18. MD on UFOs at MKIs and MKQs

    CERN Document Server

    Baer, T; Bartmann, W; Bracco, C; Carlier, E; Dehning, B; Garrel, N; Goddard, B; Jackson, S; Jimenez, M; Kain, V; Mertens, V; Misiowiec, M; Nordt, A; Papotti, G; Uythoven, J; Wenninger, J; Zerlauth, M; Zamantzas, C; Zimmermann, F

    2012-01-01

    UFOs ("Unidentified Falling Objects") are expected to be one of the major known performance limitation of the LHC. In this MD, the production mechanism and the dynamics of UFOs at the injection kicker magnets (MKIs) and the tune kicker magnets (MKQs) were studied. This was done by pulsing the MKIs and MKQs on a gap in the partly filled machine. During the MD, in total 58 UFO-type beam loss patterns were observed directly after pulsing the MKIs. None were observed after pulsing the MKQs, which provides important input for possible mitigation strategies. The temporal and spatial distribution of the UFO events could be determined by using a dedicated BLM Study Buffer, the implications for the UFO dynamics are discussed.

  19. Batch By Batch Longitudinal Emittance Blowup MD

    CERN Document Server

    Mastoridis, T; Butterworth, A; Jaussi, M; Molendijk, J

    2012-01-01

    The transverse bunch emittance increases significantly at 450 GeV from the time of injection till the ramp due to IBS. By selectively blowing up the longitudinal emittance of the incoming batch at each injection, it should be possible to reduce the transverse emittance growth rates due to IBS. An MD was conducted on April 22nd 2012 to test the feasibility and performance of the batch-by-batch longitudinal emittance blowup. There were three main goals during the MD. First, to test the developed hardware, firmware, and software for the batch-by-batch blowup. Then, to measure the transverse emittance growth rates of blown-up and "witness" batches to quantify any improvement, and finally to test the ALLInjectSequencer class, which deals with the complicated gymnastics of introducing or masking the new batch to various RF loops.

  20. Sustainability clauses in international supply chain contracts

    DEFF Research Database (Denmark)

    Peterkova, Katerina

    2014-01-01

    also to do business exclusively with socially responsible partners. Unawareness, either intentional or negligent, of unethical behaviour within a company’s supply chain may lead to an assumption that the company is complicit in such a conduct. The paper discusses a hypothesis that sustainability...... contractual clauses (SCCs) in international supply chain agreements may help to overcome the regulatory gap in relation to global sustainability while concurrently protect companies against potential social, economic and legal risks threatening in connection to unethical behaviour of their suppliers. As parts...... another corporate social responsibility tool ‘without teeth’. The central questions are: why SCCs are presumed to be effective regulatory means for global sustainability, how these clauses are seen through the lenses of international contract law and whether they can actually contribute to a positive...

  1. Integrative Medicine Program- MD Anderson Cancer Center

    OpenAIRE

    Lee, Richard T.

    2012-01-01

    The Integrative Medicine Program at MD Anderson Cancer Center was first established in 1998.  Our mission is to empower patients with cancer and their families to become active partners in their own physical, psycho-spiritual, and social health through personalized education and evidenced-based clinical care to optimize health, quality of life, and clinical outcomes across the cancer continuum.  The program consists of three main components: clinical care, research, and education.  The Integr...

  2. Ashley W. Oughterson, MD: Surgeon, Soldier, Leader

    OpenAIRE

    Kunstman, John W.; Longo, Walter E

    2015-01-01

    Ashley W. Oughterson, MD, (1895-1956) was a longtime faculty surgeon at Yale University. He performed some of the earliest pancreatic resections in the United States. During World War II, Colonel Oughterson was the primary “Surgical Consultant” in the South Pacific and present at nearly every major battle. His meticulously kept diary is regarded as the foremost source detailing wartime surgical care. Colonel Oughterson led the initial Army team to survey Hiroshima and Nagasaki following the n...

  3. Improving SAT Solvers via Blocked Clause Decomposition

    OpenAIRE

    Chen, Jingchao

    2016-01-01

    The decision variable selection policy used by the most competitive CDCL (Conflict-Driven Clause Learning) SAT solvers is either VSIDS (Variable State Independent Decaying Sum) or its variants such as exponential version EVSIDS. The common characteristic of VSIDS and its variants is to make use of statistical information in the solving process, but ignore structure information of the problem. For this reason, this paper modifies the decision variable selection policy, and presents a SAT solvi...

  4. 77 FR 73967 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Science.gov (United States)

    2012-12-12

    ... Regulation; Bear Creek, Dundalk, MD'' in the Federal Register (77 FR 5201). The rulemaking concerned would... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Bear Creek, Dundalk, MD... highway bridge at Wise Avenue across Bear Creek, mile 3.4, between Dundalk and Sparrows Point, MD....

  5. V2 word order in subordinate clauses in spoken Danish

    DEFF Research Database (Denmark)

    Jensen, Torben Juel; Christensen, Tanya Karoli

    asymmetrically distributed, we argue that the word order difference should rather be seen as a signal of (subtle) semantic differences. In main clauses, V3 is highly marked in comparison to V2, and occurs in what may be called emotives. In subordinate clauses, V2 is marked and signals what has been called...... studies of two age cohorts of speakers in Copenhagen, recorded in the 1980s and again in 2005-07, and on recent recordings with two age cohorts of speakers from the western part of Jutland. This makes it possible to study variation and change with respect to word order in subordinate clauses in both real...... and apparent time, as well as geographical variation. The results show that V2 word order in subordinate clauses is much more frequent than commonly assumed. Furthermore, they indicate that the most decisive factors predicting word order in subordinate clauses are the syntactic function of the clause...

  6. Originalism & The Scope of the Constitution's Disqualification Clause

    OpenAIRE

    Tillman, Seth Barrett

    2014-01-01

    This paper discusses the scope of the Constitution’s Disqualification Clause (Article I, Section 3, Clause 7) and the original public meaning of its “office...under the United States” language. In a recent paper in this journal, Benjamin Cassady argued that this clause bars disqualified former presidents, vice presidents, and officers of the United States from subsequent election or reelection to the presidency and vice presidency. Here, I take the contrary position: disqualified former presi...

  7. 12 CFR 34.5 - Due-on-sale clauses.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Due-on-sale clauses. 34.5 Section 34.5 Banks... General § 34.5 Due-on-sale clauses. A national bank may make or acquire a loan or interest therein, secured by a lien on real property, that includes a due-on-sale clause. Except as set forth in 12...

  8. What undertakings are protected under Umbrella Clauses of BITs.

    OpenAIRE

    Khasanov, Jamshid

    2015-01-01

    The thesis is discusses what is the scope of Umbrella Clauses. State undertakings must satisfy the condition of being investment. That is the first requirement of applicability of investment regime to state undertakings. Despite state undertakings was seen as wide concept (by some tribunals) the language of the clause and prevailing view support undertakings must be limited to contractual undertakings (in practice some viewed that Umbrella Clause can be extended to municipal law obligations) ...

  9. Synthesis of Schiff and Mannich Bases of Isatin Derivatives with 4-Amino-4,5-Dihydro-1H-1,2,4-Triazole-5-Ones

    OpenAIRE

    Hakan Bektas; Olcay Bekircan

    2008-01-01

    Ethyl imidate hydrochlorides 1 were prepared by passing HCl gas through solutions of substituted benzyl cyanides and absolute ethanol. Ethoxycarbonylhydrazones 2 were synthesized from the reaction of compounds 1 with ethyl carbazate. Treatment of 2 with hydrazine hydrate leads to the formation of substituted 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones 3. Isatin and 5-chloroisatin were added to 3 to form Schiff bases 4 and N-Mannich bases 5 of these compounds were synthesized by reacting with...

  10. Synthesis of Schiff and Mannich bases of isatin derivatives with 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones.

    Science.gov (United States)

    Bekircan, Olcay; Bektas, Hakan

    2008-01-01

    Ethyl imidate hydrochlorides 1 were prepared by passing HCl gas through solutions of substituted benzyl cyanides and absolute ethanol. Ethoxycarbonylhydrazones 2 were synthesized from the reaction of compounds 1 with ethyl carbazate. Treatment of 2 with hydrazine hydrate leads to the formation of substituted 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones 3. Isatin and 5-chloroisatin were added to 3 to form Schiff bases 4 and N-Mannich bases 5 of these compounds were synthesized by reacting with formaldehyde and piperidine. Their chemical structures were confirmed by means of IR, (1)H- and (13)C-NMR data and by elemental analysis. PMID:18830145

  11. Synthesis and Antimicrobial Activity of Schiff’s and N-Mannich Bases of Isatin and Its Derivatives with 4-Amino-N-Carbamimidoyl Benzene Sulfonamide

    Directory of Open Access Journals (Sweden)

    U. K. Singh

    2010-04-01

    Full Text Available Isatin and substituted Isatin were reacted with 4-amino-N-carbamimidoyl benzene sulfonamide to form a series of Schiff’s bases. The Mannich bases of these compounds were synthesized by reacting them with formaldehyde and secondary amine (piperidine. All the compounds were characterized by means of their IR, 1H NMR spectroscopic data and elemental analysis. The antimicrobial activity of the synthesized compounds was evaluated by tube dilution method. The synthesized compounds showed better antibacterial activity than the reference drugs.

  12. An efficient synthesis of β-amino ketone compounds through one-pot three-component Mannich-type reactions using bismuth nitrate as catalyst

    Directory of Open Access Journals (Sweden)

    S. Sheik Mansoor

    2015-07-01

    Full Text Available Three components one-pot Mannich reaction of aromatic ketone, aromatic aldehyde and aromatic amines has been efficiently catalyzed by recyclable bismuth nitrate (Bi(NO33, BN at ambient temperature to give various β-amino carbonyl compounds in high yields. This method has advantages of mild condition, no environmental pollution, and simple work-up procedures. Most importantly, β-amino carbonyl compounds with ortho-substituted aromatic amines are obtained in acceptable to moderate yields by this methodology.

  13. Integrative Medicine Program- MD Anderson Cancer Center

    Directory of Open Access Journals (Sweden)

    Richard T Lee

    2012-06-01

    Full Text Available The Integrative Medicine Program at MD Anderson Cancer Center was first established in 1998.  Our mission is to empower patients with cancer and their families to become active partners in their own physical, psycho-spiritual, and social health through personalized education and evidenced-based clinical care to optimize health, quality of life, and clinical outcomes across the cancer continuum.  The program consists of three main components: clinical care, research, and education.  The Integrative Medicine Center provides clinical services to patients through individual and group programs.  The clinical philosophy of the center is to work collaboratively with the oncology teams to build comprehensive and integrative care plans that are personalized, evidence-based, and safe with the goal of improving clinical outcomes.  The individual services comprise of integrative oncology consultation, acupuncture, meditation, music therapy, nutrition, and oncology massage.  The center also provides a variety of group programs including meditation, yoga, tai chi, cooking classes and others.  Over the past 13 years, over 70,000 patients and families have participated in services and programs offered by the center.  The research portfolio focuses on three main areas: mind-body interventions, acupuncture, and meditation.  This lecture will focus on providing an overview of the Integrative Medicine Program at MD Anderson with a focus on the clinical services provided.  Participants will learn about the integrative clinical model and how this is applied to the care of cancer patients at MD Anderson Cancer Center.  Current and future research topics will be discussed as well as patient cases.

  14. MD Test of a Ballistic Optics

    CERN Document Server

    Garcia-Tabares Valdivieso, Ana; Salvachua Ferrando, Belen Maria; Skowronski, Piotr Krzysztof; Solfaroli Camillocci, Matteo; Tomas Garcia, Rogelio; Wenninger, Jorg; Coello De Portugal - Martinez Vazquez, Jaime Maria; CERN. Geneva. ATS Department

    2016-01-01

    The ballistic optics is designed to improve the understanding of optical errors and BPM systematic effects in the critical triplet region. The particularity of that optics is that the triplet is switched off, effectively transforming the triplets on both sides of IR1 and IR5 into drift spaces. Advantage can be taken from that fact to localize better errors in the Q4-Q5-triplet region. During this MD this new optics was tested for the first time at injection with beam 2.

  15. ProtoMD: A prototyping toolkit for multiscale molecular dynamics

    Science.gov (United States)

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2016-05-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates 'GROMACS wrapper' to initiate MD simulations, and 'MDAnalysis' to analyze and manipulate trajectory files. It facilitates experimentation with a spectrum of coarse-grained variables, prototyping rare events (such as chemical reactions), or simulating nanocharacterization experiments such as terahertz spectroscopy, AFM, nanopore, and time-of-flight mass spectroscopy. ProtoMD is written in python and is freely available under the GNU General Public License from github.com/CTCNano/proto_md.

  16. Antitumor Effect of the Mannich Base(1,3-bis-((3-Hydroxynaphthalen-2-ylphenylmethylurea on Hepatocellular Carcinoma

    Directory of Open Access Journals (Sweden)

    Vadanasundari Vedarethinam

    2016-05-01

    Full Text Available The present study was designed to evaluate the antitumor effects of the synthetic Mannich base 1,3-bis-((3-hydroxynaphthalen-2-ylphenylmethylurea (1,3-BPMU against HEP-G2 hepatoma cells and diethylnitrosamine (DEN-induced hepatocarcinoma (HCC in albino rats. In vitro analysis results revealed that 1,3-BPMU showed significant cytotoxicity and cell growth inhibition in HEP-G2 hepatoma cells in a concentration-dependent manner. Furthermore, flow cytometry results indicated that 1,3-BPMU enhanced early and late apoptosis. The maximum apoptosis was exhibited at a concentration of 100 μg/mL of 1,3-BPMU. In in vivo analysis, DEN treatment increased the content of nucleic acids, LPO and the activities of AST, ALT, ALP, LDH, γGT and 5’NT with decreased antioxidant activity as compared to control rats. However, 1,3-BPMU treatment to DEN-induced rats decreased the content of nucleic acids, LPO and the activities of AST, ALT, ALP, LDH, γGT and 5’NT and increased the activities of SOD, CAT, GPx, GST and GR (p < 0.05. Furthermore, 1,3-BPMU enhanced the apoptosis via upregulation of caspase-3 and caspase-9 and the downregulation of Bcl-2 and Bcl-XL mRNA expression as compared to DEN-induced rats. Histological and ultrastructural investigation showed that 1,3-BPMU treatment renovated the internal architecture of the liver in DEN-induced rats. In this study, the molecular and pre-clinical results obtained by treatment of DEN-induced rats with 1,3-BPMU suggested that 1,3-BPMU might be considered as an antitumor compound in the future.

  17. Antitumor Effect of the Mannich Base(1,3-bis-((3-Hydroxynaphthalen-2-yl)phenylmethyl)urea) on Hepatocellular Carcinoma.

    Science.gov (United States)

    Vedarethinam, Vadanasundari; Dhanaraj, Karthik; Ilavenil, Soundharrajan; Arasu, Mariadhas Valan; Choi, Ki Choon; Al-Dhabi, Naif Abdullah; Srisesharam, Srigopalram; Lee, Kyung Dong; Kim, Da Hye; Dhanapal, Tamilvenvendan; Sivanesan, Ravikumar; Choi, Han Sung; Kim, Young Ock

    2016-01-01

    The present study was designed to evaluate the antitumor effects of the synthetic Mannich base 1,3-bis-((3-hydroxynaphthalen-2-yl)phenylmethyl)urea (1,3-BPMU) against HEP-G2 hepatoma cells and diethylnitrosamine (DEN)-induced hepatocarcinoma (HCC) in albino rats. In vitro analysis results revealed that 1,3-BPMU showed significant cytotoxicity and cell growth inhibition in HEP-G2 hepatoma cells in a concentration-dependent manner. Furthermore, flow cytometry results indicated that 1,3-BPMU enhanced early and late apoptosis. The maximum apoptosis was exhibited at a concentration of 100 μg/mL of 1,3-BPMU. In in vivo analysis, DEN treatment increased the content of nucleic acids, LPO and the activities of AST, ALT, ALP, LDH, γGT and 5'NT with decreased antioxidant activity as compared to control rats. However, 1,3-BPMU treatment to DEN-induced rats decreased the content of nucleic acids, LPO and the activities of AST, ALT, ALP, LDH, γGT and 5'NT and increased the activities of SOD, CAT, GPx, GST and GR (p < 0.05). Furthermore, 1,3-BPMU enhanced the apoptosis via upregulation of caspase-3 and caspase-9 and the downregulation of Bcl-2 and Bcl-XL mRNA expression as compared to DEN-induced rats. Histological and ultrastructural investigation showed that 1,3-BPMU treatment renovated the internal architecture of the liver in DEN-induced rats. In this study, the molecular and pre-clinical results obtained by treatment of DEN-induced rats with 1,3-BPMU suggested that 1,3-BPMU might be considered as an antitumor compound in the future. PMID:27187346

  18. The Hilbert space of conditional clauses

    Science.gov (United States)

    Francis, Charles

    2015-05-01

    In the absence of a satisfactory interpretation of quantum theory, physical law lacks physical basis. This paper reviews the orthodox, or Dirac-von Neumann interpretation, and makes explicit that Hilbert space describes propositions about measurement results. Kets are defined as conditional clauses referring to measurements in a formal language. It is seen that these clauses are elements of a Hilbert space, such that addition is logical disjunction, the dual space consists of consequent clauses, and the inner product is a set of statements in the subjunctive mood. The probability interpretation gives truth values for corresponding future tense statements when the initial state is actually prepared and the final state is to be measured. The mathematical structure of quantum mechanics is formulated in terms of discrete measurement results at finite level of accuracy and does not depend on an assumption of a substantive, or background, space-time continuum. A continuum of kets, ∣x> for x ∈ ℝ3, is constructed from linear combinations of kets in a finite basis. The inner product can be expressed either as a finite sum or as an integral. Discrete position functions are uniquely embedded into smooth wave functions in such a way that differential operators are defined. It is shown that the choice of basis has no effect on underlying physics (quantum covariance). The Dirac delta has a representation as a smooth function. Operators do not in general have an integral form. The Schrödinger equation is shown from the requirements of the probability interpretation. It is remarked that a formal construction of quantum electrodynamics (qed) avoiding divergence problems has been completed using finite dimensional Hilbert space. I conclude that quantum mechanics makes statements about the world with clear physical meaning, such that space is emergent from particle interactions and has no fundamental role.

  19. 75 FR 69862 - Airworthiness Directives; MD Helicopters, Inc. Model MD900 Helicopters

    Science.gov (United States)

    2010-11-16

    ... exist or develop on other helicopters of the same type design. Therefore, this AD requires, within 4...-AD. Applicability: Model MD900 helicopters, with lower main rotor hub (hub), part number 900R2101008... the main rotor hub (hub) for a crack. If a crack is found, this AD requires, before further...

  20. 76 FR 41662 - Airworthiness Directives; MD Helicopters, Inc. Model MD900 Helicopters

    Science.gov (United States)

    2011-07-15

    ... helicopters of this same type design. AD Requirements This AD requires a visual inspection, and if necessary...) Inspect the main rotor lower hub assembly for a crack by following the specified portions of MD Helicopter... rotor lower hub assembly (lower hub) for a crack, and if you find a crack, before further...

  1. 76 FR 1993 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Science.gov (United States)

    2011-01-12

    ... (75 FR 34661). That NPRM proposed to require installing fuel level float and pressure switch in-line... 12866, (2) Is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034... Maintenance Manual (AMM) defueling procedure MD80 AMM 12-13-00. The correct reference is Boeing MD80 AMM...

  2. 48 CFR 922.103-5 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 922.103... PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITION Basic Labor Policies 922.103-5 Contract clauses. In accordance with FAR 22.101-1(e) and FAR 22.103-5, the contracting officer shall insert...

  3. 48 CFR 1416.203-4 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1416.203-4 Section 1416.203-4 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Fixed-Price Contracts 1416.203-4 Contract clauses....

  4. 48 CFR 1428.311-1 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 1428.311... CONTRACTING REQUIREMENTS BONDS AND INSURANCE Insurance 1428.311-1 Contract clause. The CO shall modify the... in solicitations and contracts as prescribed in FAR 28.311-1....

  5. 48 CFR 709.507-2 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... solicitation or resulting contract or both include a provision in accordance with (48 CFR) FAR 9.507-1, or a clause in accordance with (48 CFR) FAR 9.507-2, establishing a restraint on the contractor's eligibility... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause....

  6. 48 CFR 3032.1110 - Solicitation provision and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... FINANCING Electronic Funds Transfer 3032.1110 Solicitation provision and contract clauses. (a)(1) Contracting officer shall insert FAR 48 CFR 52.232-33, Payment by Electronic Funds Transfer—Central Contractor... contract clauses. 3032.1110 Section 3032.1110 Federal Acquisition Regulations System DEPARTMENT OF...

  7. 48 CFR 1339.270 - Solicitation provisions and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... and contract clauses. 1339.270 Section 1339.270 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SPECIAL CATEGORIES OF CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Electronic and Information Technology 1339.270 Solicitation provisions and contract clauses. (a) Insert provision substantially...

  8. 48 CFR 5416.203-4 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Contract clauses. 5416.203... DEFENSE TYPES OF CONTRACTS Fixed Price Contracts 5416.203-4 Contract clauses. (S-90) When the contracting... reported or made available in a consistent manner in a publication, electronic database, or other form,...

  9. 48 CFR 32.1110 - Solicitation provision and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Solicitation provision and contract clauses. 32.1110 Section 32.1110 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Electronic Funds Transfer 32.1110 Solicitation provision and contract clauses....

  10. On the phrasing properties of Hindi relative clauses

    NARCIS (Netherlands)

    Gryllia, S.; Féry, C.; Kügler, F.; Pandey, P.; The, Scottish Consortium for ICPhS 2015

    2015-01-01

    This paper presents results from a production experiment in Hindi, showing that differences in attachment site of object relative clauses result in prosodic differences when the antecedent of the relative clause (RC) is part of a complex NP with the structure N1 of N2. In particular, based on durati

  11. 17 CFR Appendix B to Subpart A of... - Sample Clauses

    Science.gov (United States)

    2010-04-01

    ...) REGULATIONS S-P AND S-AM Regulation S-P: Privacy of Consumer Financial Information and Safeguarding Personal.../Joint Marketing Exception You may use one of these clauses, as applicable, to meet the requirements of... Clause A-5, Alternative 1: We may disclose the following information to companies that perform...

  12. The Acquisition of Relative Clauses by Tamil Children.

    Science.gov (United States)

    Lakshmanan, Usha

    2000-01-01

    Reports the findings of a cross-sectional study that investigated the acquisition of relative clauses by 27 Tamil-speaking children who ranged in age from 2 years and 11 months to 6 years and 6 months. A picture-cued production task was used to elicit relative clauses from the child subjects. (Author/VWL)

  13. The Production of Complement Clauses in Children with Language Impairment

    Science.gov (United States)

    Steel, Gillian; Rose, Miranda; Eadie, Patricia

    2016-01-01

    Purpose: The purpose of this research was to provide a comprehensive description of complement-clause production in children with language impairment. Complement clauses were examined with respect to types of complement structure produced, verb use, and both semantic and syntactic accuracy. Method: A group of 17 children with language impairment…

  14. The Elicited Production of Korean Relative Clauses by Heritage Speakers

    Science.gov (United States)

    Lee-Ellis, Sunyoung

    2011-01-01

    In response to new theoretical claims and inconclusive empirical findings regarding relative clauses in East Asian languages, this study examined the factors relevant to relative clause production by Korean heritage speakers. Gap position (subject vs. object), animacy (plus or minus animate), and the topicality of head nouns (plus or minus…

  15. 48 CFR 225.7403-2 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Defense Contractors Outside the United States 225.7403-2 Contract clause. Use the clause at 252.225-7043, Antiterrorism/Force Protection Policy... performance or travel outside the United States, except for contracts with— (a) Foreign governments;...

  16. 48 CFR 1019.811-3 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1019.811... PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (The 8(a) Program) 1019.811-3 Contract clauses. (d)(3) Insert theclause at DTAR 1052.219-18, Notification of...

  17. 48 CFR 1503.500-72 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Contractor Responsibility To Avoid Improper Business Practices 1503.500-72 Contract clause. As required by EPAAR 1503.500-71(b), the contracting... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clause....

  18. 37 CFR 401.13 - Administration of patent rights clauses.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Administration of patent rights clauses. 401.13 Section 401.13 Patents, Trademarks, and Copyrights ASSISTANT SECRETARY FOR... patent rights clauses. (a) In the event a subject invention is made under funding agreements of more...

  19. 32 CFR 643.55 - Mandatory revocation clause in lease.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Mandatory revocation clause in lease. 643.55... PROPERTY REAL ESTATE Leases § 643.55 Mandatory revocation clause in lease. Each lease will contain a provision permitting the SA to revoke the lease at any time, unless it is determined that the omission...

  20. ProtoMD: A prototyping toolkit for multiscale molecular dynamics

    Science.gov (United States)

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2016-05-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates 'GROMACS wrapper' to initiate MD simulations, and 'MDAnalysis' to analyze and manipulate trajectory files. It facilitates experimentation with a spectrum of coarse-grained variables, prototyping rare events (such as chemical reactions), or simulating nanocharacterization experiments such as terahertz spectroscopy, AFM, nanopore, and time-of-flight mass spectroscopy. ProtoMD is written in python and is freely available under the GNU General Public License from

  1. ‘De Regenkoning’ van Hugo Claus

    Directory of Open Access Journals (Sweden)

    S. W. van Zuydam

    1986-05-01

    Full Text Available The investigation in this article comprises the analysis of a poem by the Flemish author Hugo Claus, namely "De regenkoning". It is one of the poems in a sequence entitled "De ingewijde" (The initiated which forms part of his volume of poetry "De Oostakkerse Gedichten” (1955. These poems are extremely esoteric and an attempt is made here to “decode” the "hidden mysteries” in this particular poem. Claus’ method of using a kind of secret language corresponds to a basic feature of (universal initiation ceremonies, namely that everything that takes place is shrouded in secrecy. It was found that the nucleus of traditional initiations, namely sexual and mental maturation, likewise form a fundamental characteristic in Claus’ poem. Yet his "neophyte” is not (reborn into a "new” (sacred world, but initiated into the broken (profane realities of modern society.

  2. Computer Security: a plea to Santa Claus

    CERN Document Server

    Stefan Lueders, Computer Security Team

    2015-01-01

    Running pirated software or illegal licences, using cracking tools to bypass software activation measures, sharing music and films – these are problems that academic environments unfortunately have to deal with. All violate the copyright of the software/music/film owners, and copyright owners are not Santa Claus...    CERN, like other research organisations and universities, regularly receives allegations from external companies complaining about laptops or PCs running illegal software or sharing their films, videos or music with peers – and thus violating copyright.  Usually, we then contact the owners of the corresponding devices in order to understand whether these allegations are true. Very often such allegations boil down to a laptop whose owner replies “I confirm that a torrent client was left up and running on my device by mistake” or “This is a file that is stored on my personal hard disk.” As if those allegatio...

  3. Natural syntax : English interrogative main clauses

    Directory of Open Access Journals (Sweden)

    Janez Oresnik

    2007-05-01

    Full Text Available Natural Syntax is a developing deductive theory, a branch of Naturalness Theory. The naturalnessjudgements are couched in naturalness scales, whichfollow from the basic parameters (or «axioms» listed at the beginning of the paper. The predictions of the theory are calculated in deductions, whose chief components are apair of naturalness scales and the rules governing the alignment of corresponding naturalness values. Parallel and chiastic alignments are distinguished, in complementary distribution. Chiastic alignment is mandatory in deductions limited to unnatural environments. The paper deals with English interrogative main clauses. Within these, only the interrogatives containing wh-words exclusively insitu constitute an extremely unnatural environment and require chiastic alignment. Otherwiseparallel alignment is used. Earlier publications on Natural Syntax: Kavcic 2005a,b, Oresnik 1999, 2000a,b, 200la-f   2002, 2003a-c, 2002/03, 2004. This list cites only works written in English.

  4. Punctuation and Intonation Effects on Clause and Sentence Wrap-Up: Evidence from Eye Movements

    Science.gov (United States)

    Hirotani, Masako; Frazier, Lyn; Rayner, Keith

    2006-01-01

    Three eye movement studies examined the role of punctuation in reading. In Experiment 1, although a comma at the end of a clause facilitated overall reading times for the sentence, first pass times were longer at the end of comma-marked clauses than clauses without a comma (or the same material in clause medial position). The data supported the…

  5. Formal verification of communication protocols using quantized Horn clauses

    Science.gov (United States)

    Balu, Radhakrishnan

    2016-05-01

    The stochastic nature of quantum communication protocols naturally lends itself for expression via probabilistic logic languages. In this work we describe quantized computation using Horn clauses and base the semantics on quantum probability. Turing computable Horn clauses are very convenient to work with and the formalism can be extended to general form of first order languages. Towards this end we build a Hilbert space of H-interpretations and a corresponding non commutative von Neumann algebra of bounded linear operators. We demonstrate the expressive power of the language by casting quantum communication protocols as Horn clauses.

  6. 78 FR 35773 - Airworthiness Directives; MD Helicopters, Inc. (MDHI), Helicopters

    Science.gov (United States)

    2013-06-14

    ... the MDHI Model MD900 helicopters with certain main rotor blade (MRB) retention bolts (bolts) installed... MD 900 helicopters with a main rotor blade retention bolt (bolt), part number (P/N) 900R3100001-103... exist or develop on other products of the same type design. Related Service Information We have...

  7. MD290: Q4 IP6 Quench Level

    CERN Document Server

    Bednarek, Mateusz Jakub; Lechner, Anton; CERN. Geneva. ATS Department

    2016-01-01

    The detailed program proposed for the LHC Machine Development concerning a quench induced by fast losses on the MQY.4L6 quadrupole is presented. The merit of the MD, the necessary modifications of the machine protection systems are presented together with a preliminary analysis of the MD results.

  8. 77 FR 5201 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Science.gov (United States)

    2012-02-02

    ... Federal Register (73 FR 3316). Public Meeting We do not now plan to hold a public meeting. But you may... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Bear Creek, Dundalk, MD... across Bear Creek, mile 3.4, between Dundalk and Sparrows Point, MD. The proposed change will alter...

  9. Single-block collision attack on MD5

    NARCIS (Netherlands)

    Stevens, M.M.J.

    2012-01-01

    In 2010, Tao Xie and Dengguo Feng \\cite{cryptoeprint:2010:643} constructed the first single-block collision for MD5 consisting of two 64-byte messages that have the same MD5 hash. Details of their attack, developed using what they call an evolutionary approach, has not been disclosed ``for security

  10. 76 FR 51887 - Safety Zone; Patuxent River, Patuxent River, MD

    Science.gov (United States)

    2011-08-19

    ...) entitled ``Safety Zone; Patuxent River, Patuxent River, MD'' in the Federal Register (76 FR 36447). We... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Patuxent River, Patuxent River, MD AGENCY... safety zone during the ``NAS Patuxent River Air Expo '11,'' which consists of aerial...

  11. Chosen-Prefix Collisions for MD5 and Applications

    NARCIS (Netherlands)

    Stevens, M.M.J.; Lenstra, A.K.; Weger, B. de

    2012-01-01

    We present a novel, automated way to find differential paths for MD5. Its main application is in the construction of \\emph{chosen-prefix collisions}. We have shown how, at an approximate expected cost of $2^{39}$ calls to the MD5 compression function, for any two chosen message prefixes $P$ and $P'$

  12. DFT-MD simulations of shocked Xenon

    Science.gov (United States)

    Magyar, Rudolph J.; Mattsson, Thomas R.

    2009-03-01

    Xenon is not only a technologically important element used in laser technologies, jet propulsion and dental anesthesia, but it is also arguably the simplest material in which to study the metal-insulator transition at high pressure. Because of its closed shell electronic configuration, Xenon is often assumed to be chemically inert, interacting almost entirely through the van der Waals interaction, and at liquid density, is typically modeled well using Leonard-Jones potentials. However, such modeling has a limited range of validity as Xenon is known to form compounds at normal conditions and likely exhibits considerably more chemistry at higher densities when hybridization of occupied orbitals becomes significant. In this talk, we present DFT-MD simulations of shocked liquid Xenon with the goal of developing an improved equation of state. The relative importance of the van der Waals interaction compared to other Coulomb interactions is considered, and estimates of the relative accuracy of various density functionals are quantified. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

  13. An Analysis Of Grammatical Constructions Of Noun Clauses Found In Selected Info Articles Of Hello Magazine

    OpenAIRE

    Lestari, Triana

    2014-01-01

    This thesis entitled An Analysis Of Grammatical Construction of Noun Clauses Found in Selected Info Articles of Hello Magazine, discusses about the grammatical construction of noun clauses found in three selected info articles of Hello Magazine. There are three problems discussed in this thesis; the noun clause elements, the noun clauses patterns and the noun clauses patterns that do not follow the grammarians’ rule. The objectives of this study is to find out the elements that are used to fo...

  14. Synthesis of Schiff and Mannich Bases of Isatin Derivatives with 4-Amino-4,5-Dihydro-1H-1,2,4-Triazole-5-Ones

    Directory of Open Access Journals (Sweden)

    Hakan Bektas

    2008-09-01

    Full Text Available Ethyl imidate hydrochlorides 1 were prepared by passing HCl gas through solutions of substituted benzyl cyanides and absolute ethanol. Ethoxycarbonylhydrazones 2 were synthesized from the reaction of compounds 1 with ethyl carbazate. Treatment of 2 with hydrazine hydrate leads to the formation of substituted 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones 3. Isatin and 5-chloroisatin were added to 3 to form Schiff bases 4 and N-Mannich bases 5 of these compounds were synthesized by reacting with formaldehyde and piperidine. Their chemical structures were confirmed by means of IR, 1H- and 13C-NMR data and by elemental analysis.

  15. 曼尼希反应在木质素的改性中的应用%Application of Mannich Reaction in Modification of Lignin

    Institute of Scientific and Technical Information of China (English)

    岳萱; 乔卫红; 申凯华; 李宗石

    2001-01-01

      本文综述了木质素与脂肪胺的曼尼希反应的机理,反应物的种类和反应条件,并且详细介绍了反应产物木素胺及其衍生物在石油开采、沥青乳化、污水处理、染料分散等方面的应用进展。%  This paper reviews the mechanism, reactants and conditions of the Mannich Reaction which has been used extensively in the modification of lignin with amines. The developments of the applications of lignin amines and derivatives in oil recovery, asphalt emulsion, sewage treatment and dye dispersion have been discussed in detail.

  16. Evaluation of net antioxidant activity of mono- and bis-Mannich base hydrochlorides and 3-keto-1,5-bisphosphonates from their ProAntidex parameter

    Science.gov (United States)

    Lahbib, Karima; Tarhouni, Mohamed; Touil, Soufiane

    2015-07-01

    A series of mono- and bis-Mannich base hydrochlorides and of 3-keto-1,5-bisphosphonates were prepared and characterized on the basis of their infrared (IR), 1H, 13C and 31P NMR spectral data. All the title compounds were tested for their in vitro antioxidant activities by 1,1-diphenyl-2-picrylhydrazyl (DPPH), H2O2, hydroxyl radical and Ferric Reducing Power (FRP) methods. The antioxidant activity of these compounds was analyzed simultaneously with their pro-oxidant capacity. The ratio of pro-oxidant to the antioxidant activity (ProAntidex) represents a useful index of the net free radical scavenging potential of the synthesized compounds. Ferrous, calcium and magnesium ion chelating abilities were also evaluated. All the tested compounds showed significant antioxidant activity and high ProAntidex.

  17. What You Should Know About Writing Contract Clauses

    Science.gov (United States)

    Zweiback, Richard

    1974-01-01

    Gives tips on negotiating and writing employment contracts for teachers. Topics considered include a no-strike clause, bargaining format, administration of welfare funds, and use of the term "mutual understanding." (Author/DN)

  18. 48 CFR 1327.305 - Administration of patent rights clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administration of patent... GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights Under Government Contracts 1327.305 Administration of patent rights clauses....

  19. 48 CFR 27.305 - Administration of patent rights clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Administration of patent... REGULATION GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights under Government Contracts 27.305 Administration of patent rights clauses....

  20. 48 CFR 2427.305 - Administration of patent rights clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Administration of patent... AND URBAN DEVELOPMENT SOCIOECONOMIC PROGRAMS PATENTS, DATA, AND COPYRIGHTS Patent Rights Under Government Contracts 2427.305 Administration of patent rights clauses....

  1. 48 CFR 1227.305 - Administration of patent rights clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administration of patent... TRANSPORTATION GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights Under Government Contracts 1227.305 Administration of patent rights clauses....

  2. From Pauses to Clauses: Prosody Facilitates Learning of Syntactic Constituency

    OpenAIRE

    Hawthorne, Kara; Gerken, LouAnn

    2014-01-01

    Learning to parse the speech stream into syntactic constituents is a crucial prerequisite to adult-like sentence comprehension, and prosody is one source of information that could be used for this task. To test the role of prosody in facilitating constituent learning, 19-month-olds were familiarized with non-word sentences with 1-clause (ABCDEF) or 2-clause (ABC, DEF) prosody and were then tested on sentences that represent a grammatical (DEF, ABC) or ungrammatical (EFA, BCD) 'movement' of th...

  3. Compiling HPSG type constraints into definite clause programs

    CERN Document Server

    Götz, T; Goetz, Thilo; Meurers, Walt Detmar

    1995-01-01

    We present a new approach to HPSG processing: compiling HPSG grammars expressed as type constraints into definite clause programs. This provides a clear and computationally useful correspondence between linguistic theories and their implementation. The compiler performs off-line constraint inheritance and code optimization. As a result, we are able to efficiently process with HPSG grammars without having to hand-translate them into definite clause or phrase structure based systems.

  4. Compulsory Arbitration Clauses in Domestic and International Consumer Contracts

    OpenAIRE

    Collins, D A

    2008-01-01

    This paper examines the UK Unfair Terms in Consumer Contracts Regulations (UTCCR)'s prohibition on clauses in consumer contracts that mandate dispute settlement in an arbitration tribunal as potentially unfair and oppressive as against consumers because it denies their right to civil adjudication. The understanding of UTCCR's unfairness as developed by the UK House of Lords is not necessarily applicable to arbitration clauses because of the lower cost of such proceedings and the availability ...

  5. The scalarity of syntactic integration : syntaxic, semantic and pragmatic study of quand clause (when-clause)

    OpenAIRE

    Saez, Frédérique

    2011-01-01

    Our study about the "Quand-p" (When-clause) in modern French settles in a descriptive approach in the interlacing of syntax, semantic and discourse. Therefore we first needed to define a criteria that could debrief the variability of the Quand-p syntax. We found inspiration in the interlaced work of Smessaert et al. (2005), for the difference between micro- and macro-syntax, and of Berrendonner & Reichler-Béguelin (1989), Berrendonner (1990) and Béguelin (2004) for the macro-syntax analysis. ...

  6. The Achromatic Telescopic Squeezing (ATS) MD part III

    CERN Document Server

    Fartoukh, S; Goddard, B; Hofle, W; Jacquet, D; Kruk, G; Lamont, M; de Maria, R; Miyamoto, R; Mueller, G; Pojer, M; Ponce, L; Redaelli, S; Ryckx, N; Steinhagen, R; Strzelczyk, M; Vanbavinckhove, G; Wenninger, J

    2011-01-01

    This note highlights the results obtained during the third so-called ATS MD which took place in 2011. The goal of this MD was extremely challenging, targeting a pre-squeezed beta* of 40 cm in ATLAS and CMS, followed by a telescopic squeeze of these two insertions to finally reach a beta* of 10 cm both at IP1 and IP5. Due to the rather poor machine availability during the MD period, the time initially allocated to the ATS studies was hardly cut by a factor of 2, and "only" the achromatic pre-squeeze down to beta*=40 cm was demonstrated with beam.

  7. Single-block collision attack on MD5

    OpenAIRE

    Stevens, Marc

    2012-01-01

    In 2010, Tao Xie and Dengguo Feng \\cite{cryptoeprint:2010:643} constructed the first single-block collision for MD5 consisting of two 64-byte messages that have the same MD5 hash. Details of their attack, developed using what they call an evolutionary approach, has not been disclosed ``for security reasons''. Instead they have posted a challenge to the cryptology community to find a new different single-block collision attack for MD5. This paper answers that challenge by presenting a single-b...

  8. MD 239 on Collide and Squeeze (part 2)

    CERN Document Server

    Gorzawski, Arkadiusz; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; CERN. Geneva. ATS Department

    2016-01-01

    Colliding the beams during the squeeze to profit from Landau damping due to head--on beam-beam and beta--star leveling are two operational modes that may have to be used in a not so distant future at the LHC. This MD aimed at improving the orbit control during the squeeze with much improved handling of orbit feedback references and at evaluating instruments and techniques to maintain the beam in collisions with active feedback on luminosity or beam position. This MD also integrated for the first time synchronized collimator measurements. Comparison of the settings with the previous MD allowed a validation of the long term stability of collide and squeeze.

  9. Charge separation reaction in clusters of polar molecules. MD simulations

    International Nuclear Information System (INIS)

    Rate constant of intermolecular electron transfer (ET) in a photoexcited donor-acceptor model system solvated by a cluster of polar molecules has been expressed in terms of the statistical distribution of the electrostatic potential energy difference between the reacting sites. This distribution has been calculated for a particular case of acetonitrile clusters at ∼ 120 K by MD computer simulation. The MD values of the cluster reorganization energy and the ET rate constant have been compared with the corresponding MD results for the donor-acceptor pair solvated in bulk acetonitrile and with theoretical predictions based on the continuum model. (author)

  10. MD5Hash加密算法在SQL Server2005中的应用%Application of MD5 Hash Encryption Algorithm in SQL Server 2005

    Institute of Scientific and Technical Information of China (English)

    李红日

    2011-01-01

    在对MD5算法进行简要描述的同时,对MD5算法的原理作深入分析.介绍在C创建MD5 Hash算法的函数,在SQL Server中应用MD5哈希算法,并且经过测试可以准确实现MD5 Hash加密算法.

  11. Cryptanalysis of the Hash Function MD5%关于Hash函数MD5的解析

    Institute of Scientific and Technical Information of China (English)

    毛明; 陈少晖; 袁征; 贾永兴

    2009-01-01

    This paper is about the cryptanalysis of the Hash function MDS, on the basis of the paper concerning the breaking the MD5 which was written by Wang et al.In this paper,the eighth step of MD5 algorithm was taken for exam-ple and the properties of the F function and the effective control of the differential path were introduced.The MD5 algo-rithm was cryptanalyzed from both the manual calculation and the testing program and some part of the paper written by Wang was amended.Finally, the conditions and key points of meeting the differential characteristics were discussed.In general, this paper plays an important role in eryptanalyzing and breaking the MD5 algorithm.%在王小云写的关于分析MD5算法文章的基础上,对MD5算法的破译进行进一步的解析.以MD5算法第八步为例,介绍了F函数的性质和差分路径的有效控制.从手工推算和程序实现两方面时MD5算法进行了解析和测试,对王的文章进行了部分修正,进一步说明了满足差分特征的条件和关键点.这对MD5和其他Hash函数的分析破译有着重要的作用.

  12. Asymmetries in children's production of relative clauses: data from English and Korean.

    Science.gov (United States)

    Kim, Chae-Eun; O'Grady, William

    2016-09-01

    We report here on a series of elicited production experiments that investigate the production of indirect object and oblique relative clauses by monolingual child learners of English and Korean. Taken together, the results from the two languages point toward a pair of robust asymmetries: children manifest a preference for subject relative clauses over indirect object relative clauses, and for direct object relative clauses over oblique relative clauses. We consider various possible explanations for these preferences, of which the most promising seems to involve the requirement that the referent of the head noun be easily construed as what the relative clause is about. PMID:26264784

  13. Waiting time distribution in M/D/1 queueing systems

    DEFF Research Database (Denmark)

    Iversen, Villy Bæk; Staalhagen, Lars

    1999-01-01

    The well-known formula for the waiting time distribution of M/D/1 queueing systems is numerically unsuitable when the load is close to 1.0 and/or the results for a large waiting time are required. An algorithm for any load and waiting time is presented, based on the state probabilities of M/D/1....... The principles are also applicable for other queueing systems...

  14. Autentikasi Pesan Menggunakan Algoritma Message Digest 5 (MD5)

    OpenAIRE

    Simamora, Ali Makmur

    2015-01-01

    When receive or send a message on the network internet, there are some issue which very important namely problem wholeness and authentication. This script discusses about authentication of message with Message Digest algorithm 5. The writter designed an application to ensure the integrity of the message by algorithm MD5. MD5 is a tool to declare the validity of (authentic) sent messages as well as message. To express validity of message in the text or file will used encryption method, so the ...

  15. Legal briefing: conscience clauses and conscientious refusal.

    Science.gov (United States)

    Pope, Thaddeus Mason

    2010-01-01

    This issue's "Legal Briefing" column covers legal developments pertaining to conscience clauses and conscientious refusal. Not only has this topic been the subject of recent articles in this journal, but it has also been the subject of numerous public and professional discussions. Over the past several months, conscientious refusal disputes have had an unusually high profile not only in courthouses, but also in legislative and regulatory halls across the United States. Healthcare providers' own moral beliefs have been obstructing and are expected to increasingly obstruct patients' access to medical services. For example, some providers, on ethical or moral grounds, have denied: (1) sterilization procedures to pregnant patients, (2) pain medications in end-of-life situations, and (3) information about emergency contraception to rape victims. On the other hand, many healthcare providers have been forced to provide medical treatment that is inconsistent with their moral beliefs. There are two fundamental types of conscientious objection laws. First, there are laws that permit healthcare workers to refuse providing - on ethical, moral, or religious grounds healthcare services that they might otherwise have a legal or employer-mandated obligation to provide. Second, there are laws directed at forcing healthcare workers to provide services to which they might have ethical, moral, or religious objections. Both types of laws are rarely comprehensive, but instead target: (1) certain types of healthcare providers, (2) specific categories of healthcare services, (3) specific patient circumstances, and (4) certain conditions under which a right or obligation is triggered. For the sake of clarity, I have grouped recent legal developments concerning conscientious refusal into eight categories: 1. Abortion: right to refuse 2. Abortion: duty to provide 3. Contraception: right to refuse 4. Contraception: duty to provide 5. Sterilization: right to refuse 6. Fertility, HIV, vaccines

  16. Research of the Hash Algorithm Based on MD5%MD5散列算法的研究

    Institute of Scientific and Technical Information of China (English)

    姜学军; 曹烨

    2014-01-01

    借鉴了M.M.J.Stevens的碰撞思路,重新编写了MD5碰撞算法中的核心循环,主要提供一对MD5碰撞产生的过程以及碰撞的完成.通过实验统计分析,利用改进的MD5碰撞算法找到一对碰撞信息所用平均时间不多于60s,且该算法较之传统的MD5碰撞算法具有更好的可读性和可移植性.

  17. 48 CFR 1827.305 - Administration of the patent rights clauses.

    Science.gov (United States)

    2010-10-01

    ... patent rights clauses. 1827.305 Section 1827.305 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights Under Government Contracts 1827.305 Administration of the patent rights clauses....

  18. The Description Of Noun Clauses Found In The Jakarta Post Magazine.

    OpenAIRE

    Utami, Erlina

    2011-01-01

    A working paper entitled “The Description of Noun Clauses Found in The Jakarta Post Magazine” is about the use of noun clause in sentences contained in the articles The Jakarta Post magazine. According to Jayanthi, noun clause is a group of words which contains a subject and predicate of its own and does the work of a noun. According to Suryadi and Junaida, noun clause can be classified into four kinds, namely: statement, question, request, and exclamation, where question is ...

  19. Cummins MD & HD Accessory Hybridization CRADA -Annual Report FY15

    Energy Technology Data Exchange (ETDEWEB)

    Deter, Dean D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-10-01

    There are many areas of MD and HD vehicles that can be improved by new technologies and optimized control strategies. Component optimization and idle reduction need to be addressed, this is best done by a two part approach that includes selecting the best component technology, and/or architecture, and optimized controls that are vehicle focused. While this is a common focus in the light duty industry it has been gaining momentum in the MD and HD market as the market gets more competitive and the regulations become more stringent. When looking into systems optimization and idle reduction technologies, affected vehicle systems must first be considered, and if possible included in the new architecture to get the most benefit out of these new capabilities. Typically, when looking into idle reduction or component optimization for MD/HD, the vehicle s accessories become a prime candidate for electrification or hybridization. While this has already been studied on light duty vehicles (especially on hybrids and electric vehicles) it has not made any head way or market penetration in most MD and HD applications. If hybrids and electric MD and HD vehicles begin to break into the market this would be a necessary step into the ability to make those vehicles successful by allowing for independent, optimized operation separate from the engine.

  20. 48 CFR 15.204-3 - Part II-Contract Clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Part II-Contract Clauses... Information 15.204-3 Part II—Contract Clauses. Section I, Contract clauses. The contracting officer shall... uniform contract format. An index may be inserted if this section's format is particularly complex....

  1. Syntactic and Semantic Coordination in Finite Complement-Clause Constructions: A Diary-Based Case Study

    Science.gov (United States)

    Köymen, Bahar; Lieven, Elena; Brandt, Silke

    2016-01-01

    This study investigates the coordination of matrix and subordinate clauses within finite complement-clause constructions. The data come from diary and audio recordings which include the utterances produced by an American English-speaking child, L, between the ages 1;08 and 3;05. We extracted all the finite complement-clause constructions that L…

  2. 22 CFR 124.9 - Additional clauses required only in manufacturing license agreements.

    Science.gov (United States)

    2010-04-01

    ... manufacturing license agreements. 124.9 Section 124.9 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL... Additional clauses required only in manufacturing license agreements. (a) Clauses for all manufacturing license agreements. The following clauses must be included only in manufacturing license agreements:...

  3. 48 CFR 1852.301 - Solicitation provisions and contract clauses (Matrix).

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Solicitation provisions and contract clauses (Matrix). 1852.301 Section 1852.301 Federal Acquisition Regulations System NATIONAL... and Clause Matrix 1852.301 Solicitation provisions and contract clauses (Matrix)....

  4. 48 CFR 52.301 - Solicitation provisions and contract clauses (Matrix).

    Science.gov (United States)

    2010-10-01

    ... and Clause Matrix 52.301 Solicitation provisions and contract clauses (Matrix). Note: The FAR matrix is not carried in the CFR. It is available in the loose-leaf edition. ... and contract clauses (Matrix). 52.301 Section 52.301 Federal Acquisition Regulations System...

  5. 基于C#的MD5加密算法的应用%Application of the MD5 algorithm based on C#

    Institute of Scientific and Technical Information of China (English)

    林宗朝

    2011-01-01

    介绍了WEB SYSTEM中的密钥安全性能。主要讨论了WEB SYSTEM中MD5加密算法,包含客户password安全性分析、MD5加密算法概述、基于C#的MD5加密应用介绍,以及IT SYSTEM中MD5算法的应用与IMPROVEMENT等问题。%The key safety properties of the WEB system is described,and the.MD5 encryption algorithm is discussed mainly including the user password security analysis,MD5 encryption algorithm summary,MD5 encryption applications based on the C# and the improvement of MD5 algorithm.

  6. STUDY ON THE MANNICH REACTION OF PAM INVERSE MICROLATICES%丙烯酰胺反相微胶乳的Mannich反应研究

    Institute of Scientific and Technical Information of China (English)

    赵勇; 何炳林

    2001-01-01

    The Mannich reaction of PAM inverse microl atices were carried out in the way of microreactor for the first time, which gua ranted the balance and steadiness of reaction because of avoiding the coacervati on of microlatex particles. The experiment shows that temperature and pH value are the important influencing factors on product properties. In the experimental condition of temperature at 50 ℃ and pH at 2, aminated PAM inverse microlatices were prepared, of which amination degree was 58% and storage stability was one year.%首次选用微乳液反应器形式进行了PAM反相微胶乳的Mannich反应,由于避免了因胶乳粒子凝聚而出现的破乳现象,使得反应均衡和平稳。研究发现,温度和pH是影响产物性能的重要因素 。在T=50 ℃,pH=2的条件下,制得了胺化度为58%,稳定性长达1 a的胶乳产品。

  7. Vibrational spectra and electronic structure of 3-((1H-pyrrol-1-yl) methyl) naphthalen-2-ol - A computational insight on antioxidant active Mannich base

    Science.gov (United States)

    Boobalan, Maria susai; Tamilvendan, D.; Amaladasan, M.; Ramalingam, S.; Venkatesa Prabhu, G.; Bououdina, M.

    2015-02-01

    The 3-((1H-pyrrol-1-yl) methyl) naphthalen-2-ol (IFTN) is a class of synthesized organic Mannich base compound having antioxidant property of biological importance. A meticulous normal mode vibrational analysis has been carried out by comparing and contrasting the experimentally recorded FT-IR and FT-Raman spectra with simulated spectra of IFTN. Similarly the calculated 1H and 13C NMR of IFTN were correlated with experimental findings to understand the shielding and deshielding nature hold in it. The following other electronic structure properties were calculated such as equilibrium geometrical parameters, natural bond orbital analysis (NBO), frontier molecular orbital (FMO) characterization, statistical thermochemical properties against a range of temperatures and molecular electrostatic potential (MEP) imprint was carried out along with various charges such as APT, ESP, Hirshfeld, natural and Mulliken. All these predicted properties unlock the nature of total behavior of IFTN in various dimensions. These could be Lewis, non-Lewis interaction along with their respective energies, contribution of fragmented moieties for various orders of HOMO and LUMO, temperature consequences on enthalpy, entropy, and heat capacity. In addition, the MEP leads to find electrophilic, nucleophilic reactive sites on IFTN molecular surface. The entire computational calculations has been made on HF/6-31+G/6-311++G(d,p) and B3LYP/6-31+G/6-311++G(d,p) model chemistries. A complete electronic structure observation has been achieved by this theoretical analysis.

  8. Synthesis of formazans from Mannich base of 5-(4-chlorophenyl amino-2-mercapto-1,3,4-thiadiazole as antimicrobial agents

    Directory of Open Access Journals (Sweden)

    Pramilla Sah

    2014-04-01

    Full Text Available 5-(4-Chlorophenyl amino-2-mercapto-1,3,4-thiadiazole (I was refluxed with formaldehyde and ammonium chloride in ethanol yielding the Mannich base 5-(4-chloro phenyl amino-3-aminomethyl-2-mercapto-1,3,4-thiadiazole (II. Esterification with 4-chloro-(2,6-dinitro phenoxy-ethyl acetate (III under anhydrous conditions gave the intermediate (IV. Subsequent hydrazinolysis with hydrazine hydrate gave the corresponding hydrazide 3-amino methyl-5-(4-chloro phenyl amino-2-mercapto-4′-(2′,6′-dinitro phenoxy-acetyl hydrazide (V. The hydrazide was converted into the Schiff bases (VIa–b by reacting with 2-chlorobenzaldehyde and 3-methoxy-4-hydroxy benzaldehyde in presence of methanol containing 2–3 drops of acetic acid. Diazotisation with aromatic amines, sulphanilic acid and sulphur drugs gave the formazans (VIIa–g respectively. Chemical structures have been established by elemental analysis and the spectral techniques of FTIR, 1H NMR and mass. Antimicrobial activity (in vitro was evaluated against the two pathogenic bacterial strains. Escherichia coli and Salmonella typhi, three fungal strains Aspergillus niger, Penicillium species and Candida albicans. The compounds have shown moderate activity.

  9. BI MD Studies on June 29th 2011

    CERN Document Server

    Belohrad, D; Bravin, E; Calvo, E; Dehning, B; Emery, J; Favier, M; Gras, JJ; Guerrero, A; Jeff, A; Lefevre, T; Rabiller, A; Roncarolo, F; Sapinski, M; Soby, L; Steinhagen, R

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 29-June-2011 (from 10 p.m. to 07 a.m.), dedicated to study Beam Current Monitors (BCT), Wire Scaners (WS), Synchrotron Radiation (BSRT), Beam Position (BPM), Wall Current (WCM) and Beam Gas Ionization (BGI) monitors. The MD aimed at performing different studies on the individual monitors. At the same time, it was possible to perform calibration studies with the Abort Gap (AGM) and Longitudinal Density (LDM) monitors that share the extracted light with the BSRT. Additionally some observations about the beam stability and emittance dependence on the chromaticity were performed.

  10. 48 CFR 916.203-4 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... accordance with (FAR) 48 CFR 16.203-4. ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 916.203-4 Section 916.203-4 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING...

  11. 48 CFR 1427.201-2 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1427.201-2 Section 1427.201-2 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patents and Copyrights 1427.201-2 Contract...

  12. 48 CFR 1535.007-70 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... the Clean Air Act (42 U.S.C. 7401 et seq.), the Federal Water Pollution Control Act (33 U.S.C. 1251 et seq.), the Safe Drinking Water Act (42 U.S.C. 300f et seq.), the Federal Food, Drug, and Cosmetic Act... shall insert the clause at 48 CFR 1552.235-71, Treatment of Confidential Business Information,...

  13. 48 CFR 2009.570-5 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... nature of the proposed contract that an organizational conflict of interest exists, the contracting... COMPETITION AND ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Organizational Conflicts of Interest 2009.570-5... forth in 2009.570-4(b) must include the clause entitled, “Contractor Organizational Conflicts...

  14. 48 CFR 2409.507 - Solicitation provisions and contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Solicitation provisions and contract clause. 2409.507 Section 2409.507 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT COMPETITION AND ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Organizational...

  15. PeneLoPe, a Parallel Clause-Freezer Solver

    OpenAIRE

    Audemard, Gilles; Hoessen, Benoît; Jabbour, Said; Lagniez, Jean-Marie; Piette, Cédric

    2012-01-01

    This paper provides a short system description of our new portfolio-based solver called PeneLoPe, based on ManySat. Particularly, this solver focuses on collaboration between threads, providing different policies for exporting and importing learnt clauses between CDCL searches. Moreover, different restart strategies are also available, together with a deterministic mode.

  16. Arbitration clauses in contracts between providers and patients.

    Science.gov (United States)

    Buckner, F

    1998-01-01

    Arbitration clauses in contracts between health care providers and their patients can offer benefits to both parties. However, practitioners need to ensure that their contracts will not be judged unenforceable by a court. This article outlines the contractual and constitutional issues involved in arbitration agreements and provides advice to practitioners on drafting such an agreement. PMID:10662267

  17. 17 CFR Appendix B to Part 160 - Sample Clauses

    Science.gov (United States)

    2010-04-01

    ... FINANCIAL INFORMATION Pt. 160, App. B Appendix B to Part 160—Sample Clauses This appendix only applies to... out of disclosures to nonaffiliated third parties, you may . A-7—Confidentiality and Security (All... policies and practices with respect to protecting the confidentiality and security of nonpublic...

  18. THE EFFICACY OF THE ARBITRATION CLAUSE IN A SIMULATED ACT

    Directory of Open Access Journals (Sweden)

    Tudor Vlad RĂDULESCU

    2016-05-01

    Full Text Available The article focuses on the effects that an arbitration clause can still produce when it is contained in a simulated operation, whether it is in the apparent act or in the secret one, depending on the forms of simulation.

  19. 48 CFR 27.409 - Solicitation provisions and contract clauses

    Science.gov (United States)

    2010-10-01

    ... business innovation research contract (see paragraph (h) of this section); (iv) To be performed outside the... determines, in accordance with 27.404-2(b), to adopt the alternate definition of “Limited Rights Data” in... the contract is a Small Business Innovation Research (SBIR) contract, insert the clause at...

  20. 48 CFR 803.570-2 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 803.570-2 Section 803.570-2 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Other Improper Business Practices 803.570-2...

  1. 48 CFR 3.502-3 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clause. 3.502-3 Section 3.502-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Other Improper Business Practices 3.502-3...

  2. 48 CFR 503.570-2 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Other Improper Business Practices 503.570-2 Contract... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract clause. 503.570-2..., including acquisitions of leasehold interests in real property, if the contract amount is expected to...

  3. 48 CFR 3.503-2 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clause. 3.503-2 Section 3.503-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Other Improper Business Practices 3.503-2...

  4. 48 CFR 815.304-71 - Solicitation provision and clause.

    Science.gov (United States)

    2010-10-01

    ..., Service-Disabled Veteran-Owned and Veteran-Owned Small Business Evaluation Factors, in competitively... include VAAR clause 852.215-70, Service-Disabled Veteran-Owned and Veteran-Owned Small Business Evaluation... AFFAIRS CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection...

  5. 48 CFR 16.506 - Solicitation provisions and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... business set-aside, use the clause with its Alternate III (but see subparagraph (5) below). (5) If the... may be acquired on a brand-name basis; and (ii) Involves a partial small business set-aside, use the... REGULATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Indefinite-Delivery Contracts...

  6. 48 CFR 15.408 - Solicitation provisions and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... contract line item prices and the total contract price. You must attach cost-element breakdowns for each... and contract clauses. 15.408 Section 15.408 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Contract Pricing...

  7. 48 CFR 32.206 - Solicitation provisions and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Solicitation provisions and contract clauses. 32.206 Section 32.206 Federal Acquisition Regulations System FEDERAL ACQUISITION...) of this section); (iii) Liquidation of those financing payments by delivery payments (see...

  8. 48 CFR 32.502-4 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clauses. 32.502-4 Section 32.502-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING... concerns for the progress payment and liquidation rate indicated. (3) If an unusual progress payment...

  9. Coreference relations in complex sentence with a complement clause

    Directory of Open Access Journals (Sweden)

    Moskovljević-Popović Jasmina D.

    2015-01-01

    Full Text Available The main purpose of this paper is to analyze different co reference relations which can be established in a complex sentence between one of the arguments of the matrix clause and the understood/implicit subject of the complement clause introduced by the complementizer “da”. Various patterns of control relations which are present in contemporary Serbian - obligatory, non-obligatory, and shared control - have been enumerated and exemplified. Different types of constructions and different classes of verbs which introduce (or may introduce control relations have been identified and patterns of control instantiated by them have been described. It has been argued that the analysis of the Serbian data indicates that a type of the matrix predicate is not the only factor which determines the control relations established in a complex sentence, but that a type of situation/event described in the complement clause, as well as the relationship between the events denoted by the matrix and the complement clauses have their influence too. [Projekat Ministarstva nauke Republike Srbije, br. 178004: Standardni srpski jezik: sintaksička, semantička i pragmatička istraživanja

  10. Analysis and Transformation Tools for Constrained Horn Clause Verification

    DEFF Research Database (Denmark)

    Kafle, Bishoksan; Gallagher, John Patrick

    Several techniques and tools have been developed for verification of properties expressed as Horn clauses with constraints over a background theory (CHC). Current CHC verification tools implement intricate algorithms and are often limited to certain subclasses of CHC problems. Our aim in this wor...

  11. Decomposition by tree dimension in Horn clause verification

    DEFF Research Database (Denmark)

    Kafle, Bishoksan; Gallagher, John Patrick; Ganty, Pierre

    In this paper we investigate the use of the concept of tree dimension in Horn clause analysis and verification. The dimension of a tree is a measure of its non-linearity - for example a list of any length has dimension zero while a complete binary tree has dimension equal to its height. We apply ...

  12. 48 CFR 970.2301-2 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ..., Renewable Energy Technologies, Occupational Safety and Drug-Free Work Place 970.2301-2 Contract clauses. (a... facilities, including elements of the National Nuclear Security Administration (NNSA), the Power Marketing...-2 Section 970.2301-2 Federal Acquisition Regulations System DEPARTMENT OF ENERGY...

  13. 48 CFR 3427.470 - Publication and publicity clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Publication and publicity clause. 3427.470 Section 3427.470 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Data and Copyrights 3427.470 Publication and...

  14. 48 CFR 3427.472 - Advertising of awards clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Advertising of awards clause. 3427.472 Section 3427.472 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Data...

  15. 48 CFR 3027.305 - Administration of Patent Rights Clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Administration of Patent... SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) SOCIOECONOMIC PROGRAMS PATENTS, DATA, AND COPYRIGHTS Patent Rights under Government Contracts 3027.305 Administration of Patent Rights Clauses....

  16. 48 CFR 970.2702 - Patent related clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Patent related clauses. 970.2702 Section 970.2702 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Patents, Data, and Copyrights 970.2702...

  17. 48 CFR 50.206 - Solicitation provisions and contract clause.

    Science.gov (United States)

    2010-10-01

    ... REGULATION CONTRACT MANAGEMENT EXTRAORDINARY CONTRACTUAL ACTIONS AND THE SAFETY ACT Support Anti-terrorism by Fostering Effective Technologies Act of 2002 50.206 Solicitation provisions and contract clause. (a) Insert the provision at 52.250-2, SAFETY Act Coverage Not Applicable, in solicitations if— (1) The...

  18. The Verb Always Leaves IP in V2 Clauses

    DEFF Research Database (Denmark)

    Schwartz, Bonnie D.; Vikner, Sten

    2007-01-01

    The verb second (V2) phenomenon, as it is found in the Germanic languages, has been the focus of much attention within recent syntactic research. In most of the literature on V2, it is assumed that the verb in all V2 clauses has moved to a head position outside IP, e.g. Cº. In Schwartz & Vikner...

  19. Analysis of the message digest algorithm MD5%报文摘要算法MD5分析

    Institute of Scientific and Technical Information of China (English)

    燕辉; 叶震; 董泽浩; 高柯俊

    2002-01-01

    随着计算机网络的发展,社会对网络安全的要求也越来越紧迫。文章回顾了网络安全的目标、几种网络攻击方法和网络安全技术,重点分析了普遍用在数据签名中的MD5报文摘要算法。首先描述了MD5报文摘要算法,并对其进行了详细分析,找出了它的缺陷,最后推荐了一种为克服此缺陷而对MD5算法进行的改进方法。

  20. Hardware Implementation of HMAC-MD5 Algorithm%HMAC-MD5算法的硬件实现

    Institute of Scientific and Technical Information of China (English)

    吴旭凡; 胡晨; 田渊; 丁黄胜

    2003-01-01

    信息安全体系中的消息验证是一个非常重要的方面.采用以散列函数为基础的消息验证编码是其中的一种重要方法.现提出了硬件实现一种以MD5算法为基础的消息验证编码(HMAC-MD5)的电路结构.该电路结构通过对MD5核心运算模块的复用,缩小了电路规模,达到了较高的处理速度.用VerilogHDL描述电路结构,并且在FPGA上验证了该结构的正确性.

  1. Research and Improvement of MD5 Algorithm%MD5算法的研究与改进

    Institute of Scientific and Technical Information of China (English)

    毛熠; 陈娜

    2012-01-01

    MD5 algorithm has important applications in the field of data encryption such as digital signature, identity authentication and so on, but it can not resist differential attack and dictionary attack. This paper does certain special transform on some related variables during message preprocessing course of MD5 to improve probability of data high overflow, and increase the avalanche effect and difficulty of differential cryptanalysis, so that collision problem of MD5 algorithm is solved. Through doing collision detection, coincidence detection of encrypted values before and after improvement for improved algorithm, the improved MD5 is proved safe and practical.%MD5算法在数字签名、身份认证等数据加密领域有重要的应用,但其无法抵御差分攻击和查字典攻击.为此,通过对算法消息处理过程中涉及的一些变量进行特殊变换,提高运算中数据高位溢出的几率,增强其雪崩效应,增加差分分析的难度,由此解决MD5算法的碰撞问题.对改进的算法进行碰撞检测、加密值重合检测以及改进前后加密值的重合检测,结果证明其具有较高的安全性和实用价值.

  2. Research of MD5 shadow table method based on MD5 algorithm%一种融入MD5的影子表算法研究

    Institute of Scientific and Technical Information of China (English)

    袁满; 康峰峰; 黄刚

    2013-01-01

    As for the rapid extraction of source data, the rapid identification of changing data and the rapid incremental extraction of data, underlying the analysis of the working principle of the traditional shadow table, this paper proposed a kind of improved linear algorithm which merged MD5 algorithm into the ST. It scanned compared tables for the linear and eliminates unnecessary inverse operation. During scanning these tables, it employed MD5 algorithm to calculate the whole record ' fingerprint ' , it reduced the frequency and duration of string matching, and it could quickly recognize the changed records. The algorithm was verified practically, and the result shows that the proposed algorithm can improve the efficiency of data extraction in database. Incremental extraction method based on shadow table is a general incremental capturing method, and it can be implemented in any database. These applications can easily be transplanted in all kinds of platforms, so it is suitable to solve the heterogeneous database replication issues.%为了快速提取源头数据、快速识别变化记录以及实现数据的快速增量提取,在剖析传统影子表法的工作原理上,提出基于MD5算法的影子表法的改进型线性算法,对对比表进行线性扫描,排除了不必要的回扫操作;同时通过MD5算法计算整条记录的“指纹”,降低了字符串比对次数和时间,能够迅速识别出发生变化的记录.对所提出算法进行了应用测试,结果表明通过融入MD5算法后的影子表法提高了数据提取效率.基于影子表的增量提取方法是一种通用的增量捕获方法,能在任何数据库上实现;应用程序可以方便地在多种平台间移植,因此很适合解决异构数据库复制问题.

  3. 78 FR 3496 - Maryland Disaster Number MD-00025

    Science.gov (United States)

    2013-01-16

    ... ADMINISTRATION Maryland Disaster Number MD-00025 AGENCY: U.S. Small Business Administration. ACTION: Amendment 3... completed loan applications to: U.S. Small Business Administration, Processing and Disbursement Center... Disaster Assistance, U.S. Small Business Administration, 409 3rd Street SW., Suite 6050, Washington,...

  4. 77 FR 74908 - Maryland Disaster Number MD-00025

    Science.gov (United States)

    2012-12-18

    ... ADMINISTRATION Maryland Disaster Number MD-00025 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1... completed loan applications to: U.S. Small Business Administration, Processing and Disbursement Center... Disaster Assistance, U.S. Small Business Administration, 409 3rd Street SW., Suite 6050, Washington,...

  5. Improved Collision Attack on Hash Function MD5

    Institute of Scientific and Technical Information of China (English)

    Jie Liang; Xue-Jia Lai

    2007-01-01

    In this paper, we present a fast attack algorithm to find two-block collision of hash function MD5.The algorithm is based on the two-block collision differential path of MD5 that was presented by Wang et al.In the Conference EUROCRYPT 2005.We found that the derived conditions for the desired collision differential path were not sufficient to guarantee the path to hold and that some conditions could be modified to enlarge the collision set.By using technique of small range searching and omitting the computing steps to check the characteristics in the attack algorithm, we can speed up the attack of MD5 efficiently.Compared with the Advanced Message Modification technique presented by Wang et al.,the small range searching technique can correct 4 more conditions for the first iteration differential and 3 more conditions for the second iteration differential, thus improving the probability and the complexity to find collisions.The whole attack on the MD5 can be accomplished within 5 hours using a PC with Pentium4 1.70GHz CPU.

  6. MD on Injection Quality – Longitudinal and Transverse Parameters

    CERN Document Server

    Drosdal, L; Bohl, T; Bracco, C; Cornelis, K; Damerau, H; Goddard, B; Kain, V; Meddahi, M

    2011-01-01

    Losses at injection depend on the beam quality in the longitudinal and transverse plane in the injectors. During the MD on the 30th of June to 1st of July, 2011, many parameters in the injectors were de-tuned on purpose to see the effect on injection losses and hence bring some understanding to recurring problems with injection quality during LHC filling. The effect of the 800 MHz in the SPS, radial steering, larger momentum spread at the SPS extraction and many other longitudinal parameters were studied during the MD. The MD showed however that the injection losses are dominated by far by the transverse size of the particle population. If the SPS scrapers are correctly positioned, injection losses are low even at the presence of quality issues in the longitudinal plane. To be able to inject brighter 50 ns beams or eventually 25 ns beams, injection losses with nominal emittances (3.5 m) must still be acceptable. This MD showed that nominal emittances can be injected with similar loss levels as the typical ...

  7. 76 FR 36447 - Safety Zone; Patuxent River, Patuxent River, MD

    Science.gov (United States)

    2011-06-22

    ..., 2008, issue of the Federal Register (73 FR 3316). Public meeting We do not now plan to hold a public... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Patuxent River, Patuxent River, MD AGENCY... a temporary safety zone during the ``NAS Patuxent River Air Expo '11'', which consists of...

  8. Developing improved MD codes for understanding processive cellulases

    International Nuclear Information System (INIS)

    The mechanism of action of cellulose-degrading enzymes is illuminated through a multidisciplinary collaboration that uses molecular dynamics (MD) simulations and expands the capabilities of MD codes to allow simulations of enzymes and substrates on petascale computational facilities. There is a class of glycoside hydrolase enzymes called cellulases that are thought to decrystallize and processively depolymerize cellulose using biochemical processes that are largely not understood. Understanding the mechanisms involved and improving the efficiency of this hydrolysis process through computational models and protein engineering presents a compelling grand challenge. A detailed understanding of cellulose structure, dynamics and enzyme function at the molecular level is required to direct protein engineers to the right modifications or to understand if natural thermodynamic or kinetic limits are in play. Much can be learned about processivity by conducting carefully designed molecular dynamics (MD) simulations of the binding and catalytic domains of cellulases with various substrate configurations, solvation models and thermodynamic protocols. Most of these numerical experiments, however, will require significant modification of existing code and algorithms in order to efficiently use current (terascale) and future (petascale) hardware to the degree of parallelism necessary to simulate a system of the size proposed here. This work will develop MD codes that can efficiently use terascale and petascale systems, not just for simple classical MD simulations, but also for more advanced methods, including umbrella sampling with complex restraints and reaction coordinates, transition path sampling, steered molecular dynamics, and quantum mechanical/molecular mechanical simulations of systems the size of cellulose degrading enzymes acting on cellulose

  9. 基于乙酸为溶剂和催化剂的芳乙酮Mannich反应%Mannich Reaction of Aromatic Ketones Based on Acetic Acid as Solvent and Catalyst

    Institute of Scientific and Technical Information of China (English)

    卜辉娟; 张静; 穆博帅; 李媛

    2014-01-01

    Mannich reaction is one of the most important methods for preparation ofβ-amino ketones and alde-hydes and α,β-unsaturated carbonyl compounds, as well as one of the most important basic reaction types in organic chemistry and it is widely applied as a key step in the synthesis of numerous pharmaceuticals and natu-ral products. However, during the synthesis of 1-aryl acrylic ketone 2 by the Mannich reaction of aromatic ke-tones, formaldehyde and secondary amine using acetic acid as solvent and catalyst, the Mannich base and ex-pectedα,β-unsaturated ketones 2 were not obtained and another kind of compounds 3 , 2-aryl formyl allyl ace-tate were obtained in moderate to good yields(65%-73%) . The structure of compounds 3 was confirmed by 1 H NMR, 13 C NMR, HRMS and IR spectra. The reasons of producing compounds 3 were studied and the re-sults suggested that the special structure of aromatic ketones and excess acetic acid in reaction are responsible for the exceptional Mannich reaction. In addition, the reaction mechanism was postulated.%采用乙酸作溶剂和催化剂,将芳乙酮与甲醛和二级胺进行Mannich反应及热解反应,并未得到预期的Mannich碱或α,β-不饱和酮(2),而是以较高产率(65%~73%)生成了乙酸(2-芳甲酰基)烯丙酯(3a~3o)。通过核磁共振波谱、高分辨质谱和红外光谱表征了化合物3a~3o的结构,研究了此“异常”反应的发生条件,并提出了可能的反应机理。结果表明,芳乙酮的特殊结构及反应中过量的乙酸是产生化合物3a~3o的决定因素。

  10. Nuevos aspectos de la reacción tipo mannich en medio básico de 1,3,6,8-tetrazatriciclo[4.4.1.13,8] dodecano (tatd) con fenoles

    OpenAIRE

    Augusto Rivera; Jaime Rios Motta; Ariel Rodolfo Quevedo; Pedro Joseph Nathan

    2008-01-01

    Se ensayaron algunos fenoles como nucleófilos en la reacción tipo Mannich en medio básico frente al aminal macrocíclico1,3,6,8-tetrazatriciclo[4.4.1.1 3,8] dodecano (TATD). Dependiendo del grado de sustitución del fenol empleado, se obtuvieron:1,3- bis- [2’- hidroxibencil] imidazolidinas regioselectivamente, 2,6-di[3’-(2’’-hidroxibencil)-1’-metilenimidazolidin] fenoles y 3,3’-etilen-bis-(3,4-dihidro-2H- 1,3-benzoxazinas).

  11. Developmentally regulated expression of two MADS-box genes, MdMADS3 and MdMADS4, in the morphogenesis of flower buds and fruits in apple.

    Science.gov (United States)

    Sung, S K; Yu, G H; Nam, J; Jeong, D H; An, G

    2000-03-01

    Two MADS-box genes, MdMADS3 and MdMADS4, were isolated from the apple (Malus x domestica Borkh.) cultivar Fuji, and their spatial and temporal expression patterns were studied during morphological differentiation of the flower buds and the fruits. Both MdMADS3 and MdMADS4 showed high sequence similarities to FBP2 from petunia, TM5 from tomato, and AGL2, AGL4 from Arabidopsis. Although MdMADS3 was expressed in the inner three whorls of the floral primordium, its expression was hardly detectable in developing fruit. The second gene, MdMADS4, was ubiquitously expressed in the inflorescence meristem, floral meristem, all four floral organs, and fruit. Moreover, MdMADS4 expression was high in the vascular bundles assigned to the floral tube and the carpellary vascular bundles in fruit at early developmental stages. The MdMADS4 transcript also accumulated in embryos of the developing seeds. These results suggest that MdMADS3 and MdMADS4 are involved in different functions, and that MdMADS4 may function in the important events controlling flower and fruit development. PMID:10787044

  12. 基于MD5的迭代散列算法%Iterative Hashing Algorithm Based on MD5

    Institute of Scientific and Technical Information of China (English)

    张青

    2011-01-01

    The paper analyzes the user name and password storage methods and their risks on the internet. On this basis, it analyzes MD5 message digest encryption weaknesses and deciphering means. In response to these decoding methods, it proposes an iterative algorithm based on MD5. This algorithm is immune to the second birthday attack, meanwhile improve the complicates of the the first birthday attack. It is also useful for rainbow table attack. The algorithm can enhance password security features, thereby enhancing the network information transmission and storage security.%分析网络中用户名、密码的存储方式及其存在的风险.在此基础上分析MD5散列算法的弱点及其破译手段.针对这些破泽方法提出基于MD5的迭代散列算法.该算法可以避免第二类生日攻击,并有效提高第一类生日攻击的复杂度,对于破解效率最高的彩虹表也具有免疫性,能够加强密码的安全性能,从而提高网络中信息传递和存储的安全性.

  13. 天然黄酮Mannich碱衍生物的合成及生物活性研究%Synthesis and Bioactivity of Natural Flavones Mannich Base Derivatives

    Institute of Scientific and Technical Information of China (English)

    刘重阳; 阮文山; 王盛淳; 汪秋安

    2016-01-01

    Two naturally occurring flavones,apigenin-5,4′-dimethy ether(1) and lutedin-5,3′,4′-trimethyl ether(2),were synthesized through I2/Py dehydrogenation,O-methylation and glycoside hydrolysis reaction,using naringin and hesperidin as raw materials. Based on Mannich reaction of flavones 1 or 2 with various secondary amines and formaldehyde in acidic alcohol solvent with microwave assisted,fifteen novel flavones Mannich base derivatives 1-17 were synthesized. The structures of all synthesized compounds were confirmed by 1H NMR,13C NMR and MS techniques. Furthermore,all compounds were tested for anti-proliferative activities on human cervical carcinoma Hela cells using cell counting Kit-8(CCK-8). The results showed that compounds 1,2,7, 9,10,12 and 17 exhibited distinct anti-proliferative activities against Hela cells. Among them,compounds 10,12 and 17 displayed higher activities with inhibitory concentration 50%(IC50) of 16.13, 29.04 and 9.14 μmol/L than the positive control cis-platin (IC50 =41. 25 μmol/L).%以柚皮苷和橙皮苷为原料,经碘/吡啶脱氢,O-甲基化和糖苷水解等反应,分别合成了2种天然黄酮芹菜素-5,4′-二甲醚(1)和木犀草素-5,3′,4′-三甲醚(2)。然后以1和2为底物,分别与甲醛、二级胺在酸性醇溶剂中发生微波协助的Mannich反应,对黄酮8-位进行胺甲基化修饰,合成了15个新型黄酮Mannich碱衍生物3~17。所合成的化合物经1H NMR、13C NMR和MS等进行了结构确证,并采用细胞计数Kit-8(CCK-8)法测试了化合物1~17对子宫颈癌Hela细胞的体外抑制活性。结果表明,化合物1、2、7、9、10、12和17对Hela细胞增殖具有明显的抑制活性,其中化合物10、12和17的半数抑制浓度( IC50)分别为16.13、29.04和9.14μmol/L,活性高于阳性对照药物顺铂(IC50为41.25μmol/L)。

  14. Novel Synthesis and Anti-Microbial Activity Study of Innovative Mannich Bases Containing 2- Phenoxy-1, 3, 2-Dioxa Phospholanes And Indole Systems

    Directory of Open Access Journals (Sweden)

    Subba Narayana Kanchana

    2014-09-01

    Full Text Available In the present study, synthesis, characterization, antimicrobial activity on some novel pyrazolone derivatives has been taken up. The primary amines were diazotized with sodium nitrite and HCl mixture at 0-5 0C which were further coupled with ethyl acetoacetic ester to afford phenyl diazonium acetoacetic esters (II. Condensation of 4-substituted aryl hydrazono acetoacetic ester, 4-hydrazinylbenzenamine in the presence of catalytic amount of DMF under microwave irradiation afforded (4Z-4-(2-substituted aryl hydrazono-1-(4-aminophenyl-3-methyl-1H-pyrazol-5(4H-one (III. Subjecting (III to anhydrous K2CO3 in DMF for 8 hours afforded 2-{4-[(4Z-4-(2-substituted aryl hydrazono-4, 5-dihydro-3-methyl-5-oxopyrazol-1-yl] phenyl amino} acetate( IV which was further reacted with hydrazine hydrate to afford 2-{4-[(4Z-4-(2-substituted aryl hydrazono-4, 5-dihydro-3-methyl-5-oxopyrazol-1-yl] phenylamino} acetohydrazide (V. Reaction of (V and Isatin (VI b in DMF afforded (4Z-2-(4-((15Z-4-(2-phenylhydrazono-4,5-dihydro-3-methyl-5 oxopyrazol-1-ylphenylamino-N'-(2-oxoindolin-3-ylideneacetohydrazide (VII. Compound (VII was subsequently subjected to Mannich reaction with cyclic secondary amines (piperidine/morpholine/N-methyl piperidine in the presence of formaldehyde in DMF to afford (4Z-2-(4-((15Z-4-(2-substituted aryl hydrazono-4,5-dihydro-3-methyl-5-oxopyrazol-1-ylphenylamino-N'-(2-oxo-1-((piperidin-1-ylmethylindolin-3-ylideneacetohydrazide (VIII which was characterized by I.R, 1HNMR and Mass data. The anti-bacterial activity of synthesized compounds was studied by the disc diffusion method against pathogenic bacteria and fungi.

  15. Clause Combining in Otomi before and after contact with Spanish

    Directory of Open Access Journals (Sweden)

    Dik Bakker

    2012-01-01

    Full Text Available In this contribution, we explore two hypotheses with respect to clause combining. The first one is the assumption that languages with a mainly spoken tradition explicitly code clause relations, both coordination and subordination, to a lesser extent than languages with a long written tradition. And secondly, in case of contact between two such languages, with the latter one in a dominant position, and a sufficient level of bilingualism, we expect the former to borrow both types of relators, and increase the amount of explicit coding. We will investigate our hypotheses on the basis of Otomi, a native language from Mexico, and Spanish, the colonial language which became the official language of that country after its independence.

  16. Commerce international, clause sociale et développement durable

    OpenAIRE

    Reis, Patrice

    2010-01-01

    La dimension sociale du développement durable peut être illustrée par les débats récurrents portant sur l'insertion d'une clause sociale dans le cadre des règles de droit du commerce international portée par l'OMC. Cependant cette insertion s'avérant de plus en plus difficile, le cadre multilatéral des négociation commerciales internationales tend à être mis de coté par les Etats afin de privilégier un cadre bilatéral où la clause sociale peut plus facilement être utilisée. Article objet d'un...

  17. Renegotiation, Collective Action Clauses and Sovereign Debt Markets

    OpenAIRE

    José Wynne; Federico Weinschelbaum

    2004-01-01

    Collective action clauses (CACs) are provisions specifying that a supermajority of bondholders can change the terms of a bond. We study how CACs determine governments’ fiscal incentives, sovereign bond prices and default probabilities in environments with and without contingent debt and IMF presence. We claim that CACs are likely to be an irrelevant dimension of debt contracts in current sovereign debt markets because of the variety of instruments utilized by sovereigns and the implicit IMF...

  18. Operational Semantics of Resolution in Horn Clause Logic

    OpenAIRE

    Fu, Peng; Komendantskaya, Ekaterina

    2016-01-01

    This paper presents a study of operational and type-theoretic properties of different resolution strategies in Horn clause logic. We distinguish four different kinds of resolution: resolution by unification (SLD-resolution), resolution by term-matching, the recently introduced structural resolution, and partial (or lazy) resolution. We express them all uniformly as abstract reduction systems, which allows us to undertake a thorough comparative analysis of their properties. To match this small...

  19. Legislative versus Judiciary? The case of performance clause

    OpenAIRE

    José Paulo Martins Junior; Emilie Kalyne Munhoz; Matheus Cavalcanti Pestana

    2014-01-01

    The relations between the powers tend to be conflictive. The institutional arrangements were built for the mutually control of the powers. Since 1988, the Judiciary has been interfering and making decisions in cases that impact in the electoral and party rules in Brazil, causing discomfort to the politicians. One case was a declaration of unconstitutionality of the performance clause, defined in the Article 13 of Law 9096/95. The aim of the paper is to investigate the relation between the jud...

  20. Integrating Conflict Driven Clause Learning to Local Search

    OpenAIRE

    Audenard, Gilles; Lagniez, Jean-Marie; Mazure, Bertrand; Saïs, Lakhdar

    2009-01-01

    This article introduces SatHyS (SAT HYbrid Solver), a novel hybrid approach for propositional satisfiability. It combines local search and conflict driven clause learning (CDCL) scheme. Each time the local search part reaches a local minimum, the CDCL is launched. For SAT problems it behaves like a tabu list, whereas for UNSAT ones, the CDCL part tries to focus on minimum unsatisfiable sub-formula (MUS). Experimental results show good performances on many classes of SAT instances from the las...

  1. Using Boolean Constraint Propagation for Sub-clause Deduction

    OpenAIRE

    Darras, Sylvain; Dequen, Gilles; Devendeville, Laure; Mazure, Bertrand; Ostrowski, Richard; Sais, Lahkdar

    2005-01-01

    Boolean Constraint Propagation (BCP) is recognized as one of the most use- ful technique for efficient satisfiability checking. In this paper a new extension of the scope of boolean constraint propagation is proposed. It makes an original use of BCP to achieve further reduction of boolean formulas. Considering the impli- cation graph generated by the constraint propagation process as a resolution tree, sub-clauses from the original formula can be deduced. Then, we show how such extension can ...

  2. The Appositive NP-Complement Clause and Restructuring

    OpenAIRE

    Inada, Shun'ichiro

    2005-01-01

    This paper examines properties of Japanese Af-ga-aru construction involving an appositive NP-complement clause and presents a new approach to restructuring. The new analysis can explain the monoclausality of. sentences with an appositive NP-complement as well as that of restructuring constructions with a VP-complement. I will show that the former construction has the same properties as the latter while the former cannot be restructured at base structure or by overt operations based on two poi...

  3. MD210 Note: Creation of Hollow Bunches in the PSB

    CERN Document Server

    Oeftiger, Adrian; Findlay, Alan James; Hancock, Steven; Rumolo, Giovanni; CERN. Geneva. ATS Department

    2016-01-01

    MD210 aims for the creation of longitudinally hollow bunches in the CERN PS Booster. The first three sessions have been carried out using the radial loop feedback system in order to drive the beam on a dipolar parametric resonance (instead of the phase loop). It has been found that the damping by the phase loop inhibits the excitation of the resonance to a major extent. The hollow distributions generated under these circumstances fail to reach a satisfying bunching factor. Nonetheless, proving the principally successful application of this technique to the PS Booster promises good results once the phase loop system supports trim functions. The approach, actions and detailed results of the first three MD sessions are presented in this paper.

  4. MD 382: Beam Transfer Function and diffusion mechanisms

    CERN Document Server

    Tambasco, Claudia; Buffat, Xavier; Crouch, Matthew; Pieloni, Tatiana; Boccardi, Andrea; Fuchsberger, Kajetan; Gasior, Marek; Kotzian, Gerd; Lefevre, Thibaut; Pojer, Mirko; Salvachua Ferrando, Belen Maria; Solfaroli Camillocci, Matteo; Giachino, Rossano; CERN. Geneva. ATS Department

    2016-01-01

    The Beam Transfer Function (BTF) measurements have been previously tested in the LHC during MD block 1 and 2. Different machine configurations (i.e. energy, beam intensity, emittance etc...) have been tested to determine a safe set-up (excitation amplitude) of the system to be completely transparent to the beam (no emittance blow-up neither losses). The aim of this experiment in MD block 3 was to characterize the Stability Diagram (SD) in the presence of diffusion mechanisms induced by excited resonances due to beam-beam long range and Landau octupole interplay. During the experiment, BTF measurements have been acquired at flat top for different settings of Landau octupole current, different chromaticity values and transverse feedback gains. In this note the description of the experiment is presented together with some preliminary results.

  5. A Fast Attack Algorithm on the MD5 Hash Function

    Institute of Scientific and Technical Information of China (English)

    WANG Zhang-yi; ZHANG Huan-guo; QIN Zhong-ping; MENG Qing-shu

    2006-01-01

    The sufficient conditions for keeping desired differential path of MD5 was discussed. By analyzing the expanding of subtraction difference, differential characters of Boolean functions, and the differential characters of shift rotation, the sufficient conditions for keeping desired differential path could be obtained. From the differential characters of shift rotation, the lacked sufficient conditions were found. Then an algorithm that reduces the number of trials for finding collisions were presented. By restricting search space, search operation can be reduced tc 234 for the first block and 230 for the second block. The whole attack on the MD5 can be accomplished within 2C hours using a PC with 1.6 G CPU.

  6. Towards automatic coupling corrections with DOROS BPMs (MD750)

    CERN Document Server

    Persson, Tobias Hakan Bjorn; Langner, Andy Sven; Lefevre, Thibaut; Maclean, Ewen Hamish; Malina, Lukas; Olexa, Jakub; Skowronski, Piotr Krzysztof; Garcia-Tabares Valdivieso, Ana; Coello De Portugal - Martinez Vazquez, Jaime Maria; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2015-01-01

    BPMs close to IP1 and IP5 have been equipped with the new DOROS (Diode ORbit OScillation) system which provides precise orbit and turn-by-turn data [1]. In this MD-note we report on the rst measurements with the DOROS system to measure the transverse coupling. Furthermore, we compare the results and the performance of the system to the normal BPMs.

  7. MD 349: Impedance Localization with AC-dipole

    CERN Document Server

    Biancacci, Nicolo; Metral, Elias; Salvant, Benoit; Papotti, Giulia; Persson, Tobias Hakan Bjorn; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the distribution of the transverse impedance of the LHC by observing the phase advance variation with intensity between the machine BPMs. Four injected bunches with different intensities are excited with an AC dipole and the turn by turn data is acquired from the BPM system. Through post-processing analysis the phase variation along the machine is depicted and, from this information, first conclusions of the impedance distribution can be drawn.

  8. Analytical applications of MD-FIA-optical detection systems

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A brief introduction of recent research works in our laboratory concerning microdialysis(MD) based on optical detection combined with FIA is made in this mini-review. A biosensor system has been designed and realized the real time in vivo monitoring of some important clinic substances such as calcium, uric acid. The system has also been used to study the in vitro binding of drug-protein.

  9. Application of MD Simulations to Predict Membrane Properties of MOFs

    OpenAIRE

    Elda Adatoz; Seda Keskin

    2015-01-01

    Research Article Application of MD Simulations to Predict Membrane Properties of MOFs Elda Adatoz and Seda Keskin Chemical and Biological Engineering, Koc University, Rumelifeneri Yolu, Sariyer, 34450 Istanbul, Turkey Correspondence should be addressed to Seda Keskin; Received 22 May 2015; Accepted 13 July 2015 Academic Editor: Yanlin Song Copyright © 2015 E. Adatoz and S. Keskin. This is an open access article distributed under the Creative Commons A...

  10. A Secure Hash Function MD-192 With Modified Message Expansion

    OpenAIRE

    Harshvardhan Tiwari; Dr. Krishna Asawa

    2010-01-01

    Cryptographic hash functions play a central role in cryptography. Hash functions were introduced in cryptology to provide message integrity and authentication. MD5, SHA1 and RIPEMD are among the most commonly used message digest algorithm. Recently proposed attacks on well known and widely used hash functions motivate a design of new stronger hash function. In this paper a new approach is presented that produces 192 bit message digest and uses a modified message expansion mechanism which gene...

  11. MD 754: Instability Threshold for Train with 25ns Spacing

    CERN Document Server

    Carver, Lee Robert; Biancacci, Nicolo; Iadarola, Giovanni; Levens, Tom; Metral, Elias; Salvant, Benoit; Wang, Na; CERN. Geneva. ATS Department

    2016-01-01

    Measurements made since the beginning of run II at 6.5 TeV have shown that there is a large discrepancy in the instability thresholds between single bunches and trains of 72 bunches with 25ns spacing, whereas the same result is expect for pure impedance-induced instabilities. One possible explanation is that the presence of electron cloud is affecting the beam stability. This MD will attempt to determine if electron cloud is the dominant mechanism affecting beam stability.

  12. Can maitake MD-fraction aid cancer patients?

    Science.gov (United States)

    Kodama, Noriko; Komuta, Kiyoshi; Nanba, Hiroaki

    2002-06-01

    Maitake mushroom (Grifola frondosa) MD-fraction containing beta-1,6 glucan with beta-1,3 branched chains has previously exhibited strong anticancer activity by increasing immune-competent cell activity.1,2 In this non-random case series, a combination of MD-fraction and whole maitake powder was investigated to determine its effectiveness for 22- to 57-year-old cancer patients in stages II-IV. Cancer regression or significant symptom improvement was observed in 58.3 percent of liver cancer patients, 68.8 percent of breast cancer patients, and 62.5 percent of lung cancer patients. The trial found a less than 10-20 percent improvement for leukemia, stomach cancer, and brain cancer patients. Furthermore, when maitake was taken in addition to chemotherapy, immune-competent cell activities were enhanced 1.2-1.4 times, compared with chemotherapy alone. Animal studies have supported the use of maitake MD-fraction for cancer. PMID:12126464

  13. Review of 40-year MD theses in Medical Oncology

    International Nuclear Information System (INIS)

    Background and objective: It is almost 40 years since the foundation of the Medical Oncology (MO) Department. We aimed to appraise the clinical research to fulfill the Medical Doctorate (MD) degree in MO at the National Cancer Institute, Cairo University (NCI, CU). Methods: This review included 62 MD theses containing 66 studies. They were reviewed regarding aims, type of study, clinical trial phase, design and methodology, statistical tests, results, limitations, consent and IRB approval. Theses were grouped into 3 periods: 1970-1989, 1990-1999 and 2000- 2008. Results: Almost 76% of the studies were interventional and 24% were observational. Informed consent and Institutional Review Board approval were mentioned in 18 and 2 studies, respectively. While all studies mentioned the aims, none, clearly mentioned the research question. Outcomes were mainly efficacy followed by safety. Study design was inadequately considered, especially in 70’s–80’s period (p = 0.038). Median sample size and study duration were almost stable through the three periods (p = 0.441, 0.354, respectively). Most of the studies used both descriptive and analytical statistical methods. In a descending order, researched cancers were lymphoma, breast, leukemia, liver, urinary bladder, lung and colorectal. The commonest stages researched were IV and III. The number of studies focused on assessing biomarkers, biomarkers plus drugs/procedures, drugs and procedures are 20, 20, 16 and 6, respectively. Conclusion: With time, research within MD theses in MO increased quantitatively and qualitatively. Improvements were noticeable in documentation of study design.

  14. Structure and Properties of HELICAL CARBON NANOTUBES through MD Simulations

    Science.gov (United States)

    Dahiya, Akshay; Verma, Deepti; Gupta, Shakti S.

    Helical Carbon Nanotubes (HCNTs) are coiled 3-valent carbon networks which represent pure carbon helix. Here we study the geometries of two classes: hexagonal helix containing purely polyhex networks and the second class with 5-and 7-membered rings besides hexagons. We followed a model of hexagonal, single wall HCNTs, and determined their relaxed configuration using MD simulations based on Tersoff potential. A race-track like structure is observed in the cross-section of HCNTs upon minimization. For generating class two helix, the adjacency matrix eigenvector's (AME) method is applied which utilizes 3-coordinated tiling of the plane by 5-,6-,and 7-membered ring for the construction of helical structures. The application of the AME method to torusenes is crucial for class two helix generation as it is based on an appropriate choice of bi-lobial eigenvectors triplet which can be selected on the basis of their nodal properties as verified here. After 3-D transformations the final structure was obtained with the help of MM3-potential based MD simulations on Tinker commercial code. The spring constants of HCNTs are computed through MD simulations.

  15. Implementation of MD5 Fast Decryption Algorithm Based on Graphic Processing Unit%基于GPU的MD5高速解密算法的实现

    Institute of Scientific and Technical Information of China (English)

    乐德广; 常晋义; 刘祥南; 郭东辉

    2010-01-01

    MD5快速碰撞算法由于不支持逆向过程而无法在MD5密码攻击中得到实际应用.针对上述问题,通过分析基于图形处理单元(GPU)的MD5密码并行攻击算法原理,设计基于GPU的MD5高速解密算法,在此基础上实现一个MD5高速密码攻击系统.测试结果证明,该算法能有效加快MD5密码破解速度.

  16. Licensing clausal complements : The case of Russian čto-clauses

    OpenAIRE

    Knyazev, M

    2016-01-01

    This dissertation describes and explains the distribution of Russian complement clauses with the complementizer čto. It is shown that complement clauses with čto display distributional restrictions that are not manifested by their English and Dutch counterparts and that do not follow from the standard account of complement clauses in the literature. Two classes of environments are discussed where such restrictions are observed, namely, complements of speech act verbs in their non-agentive use...

  17. Application of MD5 Algorithm in Database System%MD5算法在数据库系统中的应用

    Institute of Scientific and Technical Information of China (English)

    罗金涛

    2013-01-01

    数据加密是保护数据安全的重要手段,MD5是目前信息安全领域中使用比较广泛的加密算法,对MD5算法的原理进行了分析,并将MD5算法应用在数据库的登录验证过程中.

  18. The Application Research of MD5 Encryption Algorithm in DCT Digital Watermarking

    Science.gov (United States)

    Xijin, Wang; Linxiu, Fan

    This article did the preliminary study of the application of algorithm for MD5 in the digital watermark. It proposed that copyright information will be encrypted using an algorithm MD5, and made rules for the second value image watermarks, through DCT algorithm that embeds an image by the carrier. The extraction algorithms can pick up the watermark and restore MD5 code.

  19. Application of MD5 Encryption Algorithm Based on C# Technology%基于C#技术的MD5加密算法的应用

    Institute of Scientific and Technical Information of China (English)

    王倩丽

    2010-01-01

    在对Message-Digest Algorithm 5进行简要描述的同时,对MD5算法的原理作深入分析.运用MD5算法,采用目前流行的C#语言进行了具体研究,设计了MD5加密演示系统,经过测试该系统可以准确实现数据的MD5加密.

  20. MD5算法在用户口令认证中的应用%The Application of MD5 Algorithm in The User Password Authentication

    Institute of Scientific and Technical Information of China (English)

    刘洪民; 印帮辉

    2014-01-01

    MD5算法是目前比较安全且易用的加密算法,其在密码领域有着举足轻重的地位.本文通过介绍MD5算法的特点及加密原理,分析了MD5算法在用户口令认证中的安全隐患,给出了用户口令认证应用中如何提高MD5算法安全性的措施和方法.

  1. A Secure Hash Function MD-192 With Modified Message Expansion

    CERN Document Server

    Tiwari, Harshvardhan

    2010-01-01

    Cryptographic hash functions play a central role in cryptography. Hash functions were introduced in cryptology to provide message integrity and authentication. MD5, SHA1 and RIPEMD are among the most commonly used message digest algorithm. Recently proposed attacks on well known and widely used hash functions motivate a design of new stronger hash function. In this paper a new approach is presented that produces 192 bit message digest and uses a modified message expansion mechanism which generates more bit difference in each working variable to make the algorithm more secure. This hash function is collision resistant and assures a good compression and preimage resistance.

  2. Integrating Conflict Driven Clause Learning to Local Search

    CERN Document Server

    Audenard, Gilles; Mazure, Bertrand; Saïs, Lakhdar

    2009-01-01

    This article introduces SatHyS (SAT HYbrid Solver), a novel hybrid approach for propositional satisfiability. It combines local search and conflict driven clause learning (CDCL) scheme. Each time the local search part reaches a local minimum, the CDCL is launched. For SAT problems it behaves like a tabu list, whereas for UNSAT ones, the CDCL part tries to focus on minimum unsatisfiable sub-formula (MUS). Experimental results show good performances on many classes of SAT instances from the last SAT competitions.

  3. Integrating Conflict Driven Clause Learning to Local Search

    Directory of Open Access Journals (Sweden)

    Gilles Audenard

    2009-10-01

    Full Text Available This article introduces SatHyS (SAT HYbrid Solver, a novel hybrid approach for propositional satisfiability. It combines local search and conflict driven clause learning (CDCL scheme. Each time the local search part reaches a local minimum, the CDCL is launched. For SAT problems it behaves like a tabu list, whereas for UNSAT ones, the CDCL part tries to focus on minimum unsatisfiable sub-formula (MUS. Experimental results show good performances on many classes of SAT instances from the last SAT competitions.

  4. Signaling Elaboration: Combining French Gerund Clauses with Lexical Cohesion Cues

    Directory of Open Access Journals (Sweden)

    Marianne Vergez-Couret

    2012-07-01

    Full Text Available In this paper, we focus on the Elaboration relation and on its automatic identification in French, using the theoretical framework of Segmented Discourse Representation Theory (SDRT. One of the information sources identified by the SDRT framework to infer the Elaboration relation is based on the existence of a potential subsumption link between the eventualities at stake, depending on lexical semantics and world knowledge. We investigate this claim by combining a weak syntactic marker of the Elaboration relation, namely the gerund clause, with lexical cohesion cues. We aim at automatically identifying gerund clauses which are Elaborations by finding cohesive links between the host main clause and the gerund clause. This approach makes it possible to accurately detect few cases of intra-sentential Elaborations in our corpus, confirming the fact that lexical cohesion cues are relevant for this task.Dans cet article, nous nous focalisons sur la relation d’Élaboration en français, telle qu’elle est décrite dans le modèle théorique de la SDRT (Segmented Discourse Representation Theory, et sur son identification automatique. Selon la SDRT, une des sources d’information permettant d’inférer la relation d’Élaboration est basée sur l’existence d’un lien de subsomption entre les types des éventualités des segments à relier, indiquant que le type de la seconde éventualité est un sous-type de celui de la première dans la sémantique lexicale des éventualités ou grâce à des connaissances du monde. Nous proposons de contribuer à cette question en combinant un indice de la relation d’Élaboration, i. e. la construction syntaxique du gérondif, et des indices de cohésion lexicale. Notre objectif est d’identifier automatiquement des propositions gérondives qui sont des Élaborations en repérant des indices de cohésion lexicale entre la proposition principale et la proposition gérondive. Cette approche permet de d

  5. 散列算法MD5和SHA-1的比较%Comparison between MD5 and SHA-1

    Institute of Scientific and Technical Information of China (English)

    王泽; 曹莉莎

    2016-01-01

    MD5 and SHA-1 are the two known Hash Algorithm which are widely applied in information security, they are both developed from MD4.This paper introduces their algorithm logic in detail, compares them though simulation experiment ,soft-ware testing, etc. Finally, it draw a conclusion:The SHA-1 algorithm is more secure than the MD5 algorithm, but in the same hardware, SHA-1 is slower than MD5.%MD5和SHA-1是两个已知的广泛应用于信息安全的散列算法,均由MD4发展而来。详细介绍了它们的算法逻辑,并通过模拟实验、软件测试等方式对其在各个方面进行比较,最终得出结论:SHA-1算法比MD5算法的安全性更高,但在同一硬件上,SHA-1比MD5运行的要慢。

  6. Preparation and Properties of A Novel Modified Mannich Amine as Waterborne Epoxy Curing Agent%改性曼尼希胺水性环氧固化剂的制备及性能

    Institute of Scientific and Technical Information of China (English)

    李楚新; 段颖; 丁嘉欣; 夏新年

    2012-01-01

    A novel Modified Mannich Amine ( MAI ) was synthesized by amine exchange reaction using polyether amine (D -230) and DMP -30 as raw materials. A liquid epoxy resin (EP) and a homemade mono -functional epoxy polymer (PEG - EP) were used as chain extender for MAl's chain extension modifica tion, which was then terminated with phenyl glycidyl ether(PGE) to get Modified Mannich Amine(MA3). Finally, the Mannich amine waterborne epoxy curing agents ( CAs) were produced by phase - inversion e- mulsification method and used for waterborne epoxy resin. The influences of the PEG - EP amount, the feed ing ratio of MA1/EP and MAI/PEG on the stability of the dispersion were studied. The chemical structures and properties of the cured films were studied by physical chemistry method. The cured films of an optimiza tion system showed a hardness 229 s, flexibility 1 mm, adhesion 0 grade, pot ?life 5 h, and excellent water resistance.%以聚醚胺(D - 230)和DMP - 30为原料,利用胺交换反应制得一种新型的改性曼尼希胺(MAI).然后以自制的端官能环氧聚合物( PEG - EP)与低相对分子质量液体环氧树脂(EP)为扩链剂对MAI进行扩链改性,并用苯基缩水甘油醚(PGE)封端,最后采用相反转法制得了一种新型的改性曼尼希水性环氧固化剂.讨论了PEG - EP的添加量、MAI与EP的加料比及封端剂的添加量对水性固化剂体系稳定性的影响.并采用物理化学方法对反应程度及涂膜的性能进能了表征分析.优化体系固化涂膜硬度229s,柔韧性1mm,附着力0级,适用期5h,耐水性优异.

  7. 48 CFR 952.223 - Clauses related to environment, energy and water efficiency, renewable energy technologies...

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Clauses related to environment, energy and water efficiency, renewable energy technologies, occupational safety, and drug-free workplace. 952.223 Section 952.223 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND...

  8. 78 FR 48397 - Defense Federal Acquisition Regulation Supplement: Clauses With Alternates-Transportation (DFARS...

    Science.gov (United States)

    2013-08-08

    ...-city or intra-area movement, is contemplated. (1) Use the clause Requirements--Basic if the acquisition..., or for performance of intra-city or intra-area movement, use the following provisions, clauses, and... facilities; ships; floating equipment and vessels of every character, type, and description, with...

  9. 48 CFR 639.107-70 - DOSAR solicitation provision and contract clause.

    Science.gov (United States)

    2010-10-01

    ... provision and contract clause. 639.107-70 Section 639.107-70 Federal Acquisition Regulations System...-70 DOSAR solicitation provision and contract clause. (a) The contracting officer shall insert the... electronic access to Department information that directly supports the mission of the Department. (b)...

  10. 48 CFR 339.201-70 - Required provision and contract clause.

    Science.gov (United States)

    2010-10-01

    ... contract clause. 339.201-70 Section 339.201-70 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES SPECIAL CATEGORIES OF CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Electronic and Information Technology 339.201-70 Required provision and contract clause. (a) The Contracting Officer shall insert...

  11. 77 FR 50454 - Department of the Treasury Acquisition Regulations; Contract Clause on Minority and Women...

    Science.gov (United States)

    2012-08-21

    ... 48 CFR Chapter 10 RIN 1505-AC40 Department of the Treasury Acquisition Regulations; Contract Clause... proposing to amend the Department of the Treasury Acquisition Regulation (DTAR) to include a contract clause..., 1500 Pennsylvania Avenue NW., Washington, DC 20220. Fax and email comments will not be...

  12. 78 FR 48404 - Defense Federal Acquisition Regulation Supplement: Clauses With Alternates-Contract Financing...

    Science.gov (United States)

    2013-08-08

    ... Regulation Supplement: Clauses With Alternates--Contract Financing (DFARS Case 2013-D014) AGENCY: Defense... prescription for the set of contract financing related clauses with one or more alternates. The rule also... your name, company name (if any), and ``DFARS Case 2013-D014'' on your attached document. Email:...

  13. Rahft: A Tool for Verifying Horn Clauses Using Abstract Interpretation and Finite Tree Automata

    DEFF Research Database (Denmark)

    Kafle, Bishoksan; Gallagher, John Patrick; Morales, José F.

    2016-01-01

    We present Rahft (Refinement of Abstraction in Horn clauses using Finite Tree automata), an abstraction refinement tool for verifying safety properties of programs expressed as Horn clauses. The paper describes the architecture, strength and weakness, implementation and usage aspects of the tool...

  14. 21 CFR 571.115 - Application of the cancer clause of section 409 of the act.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Application of the cancer clause of section 409 of the act. 571.115 Section 571.115 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... Administrative Actions on Applications § 571.115 Application of the cancer clause of section 409 of the act....

  15. 21 CFR 70.50 - Application of the cancer clause of section 721 of the act.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Application of the cancer clause of section 721 of the act. 70.50 Section 70.50 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL COLOR ADDITIVES Safety Evaluation § 70.50 Application of the cancer clause...

  16. Moulding Interpersonal Relations through Conditional Clauses: Consensus-Building Strategies in Written Academic Discourse

    Science.gov (United States)

    Warchal, Krystyna

    2010-01-01

    This paper focuses on the interpersonal potential of the conditional clause as a rhetorical device for establishing a dialogue between the author and the reader of an academic text in search for shared understanding and consensus. It presents a corpus-based analysis of functions conditional clauses play in linguistics research articles in an…

  17. Convex polyhedral abstractions, specialisation and property-based predicate splitting in Horn clause verification

    DEFF Research Database (Denmark)

    Kafle, Bishoksan; Gallagher, John Patrick

    We present an approach to constrained Horn clause (CHC) verification combining three techniques: abstract interpretation over a domain of convex polyhedra, specialisation of the constraints in CHCs using abstract interpretation of query-answer transformed clauses, and refinement by splitting pred...

  18. 48 CFR 1352.301 - Solicitation provisions and contract clauses (Matrix).

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Solicitation provisions and contract clauses (Matrix). 1352.301 Section 1352.301 Federal Acquisition Regulations System... Matrix 1352.301 Solicitation provisions and contract clauses (Matrix). ER08MR10.000 ER08MR10.001...

  19. MD5加密算法的研究及应用%Research and application of MD5 encryption algorithm

    Institute of Scientific and Technical Information of China (English)

    魏晓玲

    2010-01-01

    针对当前网站建设和系统开发中用户信息等重要数据的安全问题,提出了一种MD5加密算法,可以对用户密码进行加密.MD5加密算法是一种比较常用的单向加密算法,通过对该算法的深入研究,介绍了MD5算法的特性、算法原理及其算法流程,并给出MD5算法在一个具体系统中的实际应用,得出MD5算法是一种非常安全和易用的加密算法.

  20. Reverse Crack of MD5 Encryption and Its Safety Improvement%MD5加密逆向破解及安全性改进

    Institute of Scientific and Technical Information of China (English)

    王雄; 朱志祥; 许辉辉

    2014-01-01

    针对消息摘要算法第五版(Message-Digest Algorithm 5,MD5)不可逆的特性,通过组建Oracle明文数据库、调用MD5函数,建立明文与MD5码之间的一一对应关系,实现了对MD5加密的逆向破解.从应对碰撞攻击和反向查询两方面,总结多种改进措施,提高了MD5加密算法在实际应用中的安全性.

  1. Cause Clue Clauses: Error Localization using Maximum Satisfiability

    CERN Document Server

    Jose, Manu

    2010-01-01

    Much effort is spent everyday by programmers trying to reduce long, failing execution traces to the cause of the error. We present a new algorithm for error cause localization based on a reduction to the maximal satisfiability problem (MAX SAT), which asks what is the maximum number of clauses of a Boolean formula that can be satisfied by an assignment. At an intuitive level, our algorithm takes as input a program and a failing test, and comprises the following three steps. First, as in symbolic execution, we encode a trace of a program as a Boolean trace formula which is satisfiable iff the trace is feasible. Second, for a failing program execution (e.g., one that violates an assertion or a post condition), we construct an unsatisfiable formula by taking the trace formula and additionally asserting that the input is the failing test and that the post-condition holds. Third, using MAX-SAT, we find a maximal set of clauses in this formula that can be satisfied together, and output the complement set as a poten...

  2. 48 CFR 1832.1110 - Solicitation provision and contract clauses. (NASA supplements paragraphs (a), (b), and (c)).

    Science.gov (United States)

    2010-10-01

    ... CONTRACT FINANCING Electronic Funds Transfer 1832.1110 Solicitation provision and contract clauses. (NASA... contract clauses. (NASA supplements paragraphs (a), (b), and (c)). 1832.1110 Section 1832.1110 Federal... the clause at FAR 52.232-34, Payment by Electronic Funds Transfer—Other than Central...

  3. Design, synthesis and preliminary structure-activity relationship investigation of nitrogen-containing chalcone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors: a further study based on Flavokawain B Mannich base derivatives.

    Science.gov (United States)

    Liu, Haoran; Fan, Haoqun; Gao, Xiaohui; Huang, Xueqing; Liu, Xianjun; Liu, Linbo; Zhou, Chao; Tang, Jingjing; Wang, Qiuan; Liu, Wukun

    2016-08-01

    In order to study the structure-activity relationship of Flavokawain B Mannich-based derivatives as acetylcholinesterase (AChE) inhibitors in our recent investigation, 20 new nitrogen-containing chalcone derivatives (4 a-8d) were designed, synthesized, and evaluated for AChE inhibitory activity in vitro. The results suggested that amino alkyl side chain of chalcone dramatically influenced the inhibitory activity against AChE. Among them, compound 6c revealed the strongest AChE inhibitory activity (IC50 value: 0.85 μmol/L) and the highest selectivity against AChE over BuChE (ratio: 35.79). Enzyme kinetic study showed that the inhibition mechanism of compound 6c against AChE was a mixed-type inhibition. The molecular docking assay showed that this compound can both bind with the catalytic site and the peripheral site of AChE. PMID:26186269

  4. [Professor Frantisek Por MD and Professor Robert Klopstock MD, students at Budapest and Prague Faculties of Medicine].

    Science.gov (United States)

    Mydlík, M; Derzsiová, K

    2010-11-01

    Professor Frantisek Por MD and Professor Robert Klopstock MD were contemporaries, both born in 1899, one in Zvolen, the other in Dombovar, at the time of Austro-Hungarian Monarchy. Prof. Por attended the Faculty of Medicine in Budapest from 1918 to 1920, and Prof. Klopstock studied at the same place between 1917 and 1919. From 1920 until graduation on 6th February 1926, Prof. Por continued his studies at the German Faculty of Medicine, Charles University in Prague. Prof. Klopstock had to interrupt his studies in Budapest due to pulmonary tuberculosis; he received treatment at Tatranske Matliare where he befriended Franz Kafka. Later, upon Kafka's encouragement, he changed institutions and continued his studies at the German Faculty of Medicine, Charles University in Prague, where he graduated the first great go. It is very likely that, during their studies in Budapest and Prague, both professors met repeatedly, even though their life paths later separated. Following his graduation, Prof. Por practiced as an internist in Prague, later in Slovakia, and from 1945 in Kosice. In 1961, he was awarded the title of university professor of internal medicine at the Faculty of Medicine, Pavol Jozef Safarik University in Kosice, where he practiced until his death in 1980. Prof. Klopstock continued his studies in Kiel and Berlin. After his graduation in 1933, he practiced in Berlin as a surgeon and in 1938 left for USA. In 1962, he was awarded the title of university professor of pulmonary surgery in NewYork, where he died in 1972. PMID:21250499

  5. 基于简化MD5的TFIDF算法%TFIDF Algorithm Based on a Simplified MD5

    Institute of Scientific and Technical Information of China (English)

    刘雅正; 陈受凯; 唐向阳

    2012-01-01

    随着信息技术不断的发展,海量数据的处理效率成为不可逃避的问题.传统的网页分类算法在分类效果上已经相对成熟,所以在这样的背景下从传统网页分类算法中特征值权重算法的效率和代价出发,分析并提出了基于简化MD5的特征值权重算法.有效减少了特征值提取时的比对和最后一次排序的效率,从而提高了整个网页分类的效率.%With the rapid development of information technology, the process efficiency of massive data has become inescapable problem and Web page classification algorithm has matured yet, so from the efficiency and cost of eigenvalue weights algorithm in traditional web page classification algorithm is started. Eigenvalue weights algorithm based on a simplified MD5, and effective in reducing the efficiency of eigenvalue extraction time and the last sort of eigenvalue are analyzed and proposed. Improving the efficiency of the whole Web page classification is presented.

  6. The cultivar-specific expression patterns of MdACS3 gene and apple fruit ripening and quality

    Science.gov (United States)

    Ethylene plays an important role in diverse physiological and developmental processes of plants. In apple, two ethylene biosynthesis genes, MdACS1 and MdACS3, are expressed in fruit tissues. While MdACS1 expresses at late ripening stages, expression of MdACS3 can be detected as early as 6 weeks bef...

  7. The role of cultivar-specific expression patterns of MdACS3 gene on apple fruit ripening and quality

    Science.gov (United States)

    Ethylene plays an important role in diverse physiological and developmental processes of plants. In apple, two ethylene biosynthesis genes, MdACS1 and MdACS3, are expressed in fruit tissues. While MdACS1 expresses at late ripening stages, expression of MdACS3 can be detected as early as 6 weeks befo...

  8. The improvement of cryptography MD5 algorithm%密码学中信息摘要算法MD5的改进

    Institute of Scientific and Technical Information of China (English)

    林平

    2011-01-01

    MD5算法的基础上,针对MD5算法密文是一个32位16进制字符来表示值的特征,提出MD5改进算法,首先采用替换加密算法Md5Replace加密MD5算法密文,隐藏MD5算法密文的特征;再选定替换加密密文中某一位置插入由随机函数算法Md5Random产生定长的字符串得到最后的密文,改变了替换加密密文位数,隐藏了替换加密算法替换规律.在不改变算法效率的前提下,提高算法安全强度.

  9. 报文摘要算法MD5的分析与改进

    Institute of Scientific and Technical Information of China (English)

    汪勋亮; 赵春霞; 郭剑辉

    2014-01-01

    MD5算法在数据加密方面有着广泛的应用,但是它无法抵御查字典攻击和差分等攻击。为此本文介绍了报文算法MD5和Base64算法,以及在两种算法的基础上提出了MD5的改进算法,以应对以上被攻击的缺陷。%MD5 encryption algorithm in the data has a wide range of applications,but it can not resist dictionary attacks and differential attacks.This paper introduces the MD5 message digest algorithm and Base64 algorithm,and two algorithms based on the proposed the improved MD5 algorithm,the effect is to deal with the above attack.

  10. Fred Loe, MD, and the history of trachoma.

    Science.gov (United States)

    Feibel, Robert M

    2011-04-01

    Trachoma has been one of the most blinding diseases in the history of ophthalmology. From its initial description in antiquity until the late 1930s, no specific treatment or effective cure had been known, and the only expedient had been to destroy the diseased tissue containing the infectious agent, rendering the disease inactive. Virtually all medical, mechanical, and surgical treatments were unsatisfactory, with cure rates of approximately 20%. Therapy for trachoma had barely advanced from the measures used by the ancient Egyptian, Greek, and Roman physicians. All prior therapies became obsolete in 1938 when Fred Loe, MD, working on an American Indian reservation, introduced sulfanilamide as a treatment of trachoma, achieving a 90% cure rate. One of the most unusual aspects of Loe's career was that he had no formal training in ophthalmology and was completely self-taught as an ophthalmologist. PMID:21482877

  11. A workshop on leadership for MD/PhD students

    Directory of Open Access Journals (Sweden)

    Mark D. Cannon

    2011-08-01

    Full Text Available Success in academic medicine requires scientific and clinical aptitude and the ability to lead a team effectively. Although combined MD/PhD training programs invest considerably in the former, they often do not provide structured educational opportunities in leadership, especially as applied to investigative medicine. To fill a critical knowledge gap in physician-scientist training, the Vanderbilt Medical Scientist Training Program (MSTP developed a biennial two-day workshop in investigative leadership. MSTP students worked in partnership with content experts to develop a case-based curriculum and deliver the material. In its initial three offerings in 2006, 2008, and 2010, the workshop was judged by MSTP student attendees to be highly effective. The Vanderbilt MSTP Leadership Workshop offers a blueprint for collaborative student-faculty interactions in curriculum design and a new educational modality for physician-scientist training.

  12. Thermal Sensitivity of MD Hematite: Implication for Magnetic Anomalies

    Science.gov (United States)

    Kletetschka, Gunther; Wasilewski, Peter J.; Taylor, Patrick T.

    1999-01-01

    Magnetic remanence of crustal rocks can reside in three common rock-forming magnetic minerals: magnetite, pyrrhotite, and hematite. Thermoremanent magnetization (TRM) of magnetite and pyrrhotite is carried mostly by single domain (SD) grains. The TRM of hematite grains, however, is carried mostly by multidomain (NM) grains. This characteristic is illustrated by TRM acquisition curves for hematite of variable grainsizes. The transition between truly NM behavior and tendency towards SD behavior his been established between hematite grainsizes of 0. 1 and 0.05 mm. Coarse grainsize of lower crustal rocks and the large sensitivity of MD hematite grains to acquire TRM indicates that hematite could be a significant contributor to long-wavelength magnetic anomalies.

  13. BayesMD: flexible biological modeling for motif discovery

    DEFF Research Database (Denmark)

    Tang, Man-Hung Eric; Krogh, Anders; Winther, Ole

    2008-01-01

    and the marginal probabilities can be used directly to assess the significance of the findings. The framework is benchmarked against other methods on a number of real and artificial data sets. The accompanying prediction server, documentation, software, models and data are available from http://bayesmd.binf.ku.dk/.......We present BayesMD, a Bayesian Motif Discovery model with several new features. Three different types of biological a priori knowledge are built into the framework in a modular fashion. A mixture of Dirichlets is used as prior over nucleotide probabilities in binding sites. It is trained...... sampling results are achieved using the advanced sampling method parallel tempering. In a post-analysis step candidate motifs with high marginal probability are found by searching among those motifs that contain sites that occur frequently. Thereby, maximum a posteriori inference for the motifs is avoided...

  14. Plasticity and Failure in Nanocrystalline BCC Metals via MD Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Rudd, R E

    2010-02-12

    Advances in the ability to generate extremely high pressures in dynamic experiments such as at the National Ignition Facility has motivated the need for special materials optimized for those conditions as well as ways to probe the response of these materials as they are deformed. We need to develop a much deeper understanding of the behavior of materials subjected to high pressure, especially the effect of rate at the extremely high rates encountered in those experiments. Here we use large-scale molecular dynamics (MD) simulations of the high-rate deformation of nanocrystalline tantalum at pressures less than 100 GPa to investigate the processes associated with plastic deformation for strains up to 100%. We focus on 3D polycrystalline systems with typical grain sizes of 10-20 nm. We also study a rapidly quenched liquid (amorphous solid) tantalum. We apply a constant volume (isochoric), constant temperature (isothermal) shear deformation over a range of strain rates, and compute the resulting stress-strain curves to large strains for both uniaxial and biaxial compression. We study the rate dependence and identify plastic deformation mechanisms. The identification of the mechanisms is facilitated through a novel technique that computes the local grain orientation, returning it as a quaternion for each atom. This analysis technique is robust and fast, and has been used to compute the orientations on the fly during our parallel MD simulations on supercomputers. We find both dislocation and twinning processes are important, and they interact in the weak strain hardening in these extremely fine-grained microstructures. We also present some results on void growth in nanocrystalline BCC metals under tension.

  15. WEB登录系统中MD5加密算法的PHP实现%PHP Implementation of MD5 Encryption Algorithm in WEB Login System

    Institute of Scientific and Technical Information of China (English)

    王雄; 李旭辉; 许琳华

    2011-01-01

    MD5是web应用程序中常用的加密算法,很多网站的登录模块都采用了MD5加密,用户登录密码通过使用它加密存储到数据库当中,在一定程度上使入侵者不易获得用户登录权限.本文分析比较了中MD5不同的改进算法,并给出了最后的结论.

  16. MD&A – Counterpart to or Distraction from Financial Reporting

    OpenAIRE

    Kevin Girdharry; Elena Simonova; Rock Lefebvre

    2011-01-01

    MD&A content has been an ongoing topic of recent debate with the views divided on the impact that regulated content has on the quality of the MD&A. Complexity has amplified as a result of emerging issues of particular importance to investors such as transition to IFRS, the environment and executive compensation. This paper examines companies’ compliance with requirements of the Canadian Securities Administrators for MD&A disclosures, and aims to advance understand on whether following CSA req...

  17. THE ROLE OF THE GRAMMAR ON PORTUGUESE TEXTBOOKS: A LOOK ON TEACHING OF RELATIVE CLAUSE

    Directory of Open Access Journals (Sweden)

    Lília Santos ABREU-TARDELLI

    2014-12-01

    Full Text Available This paper studies how the textbooks of Portuguese Language of Secondary School, approved by the Programa Nacional do Livro Didático-2014, approach the teaching of grammar, in particular as regards the treatment of the relative subordinate clause. For this, first we start with the comparison between the proposals manuals for teaching grammar and what was accomplished in the student book. Furthermore, we propose here an interface between the results of the analysis of textbooks and functional description of the relative clause. In other words, we try to verify as some descriptive aspects can be used in the teaching of relative clause, with the aim of developing reading and writing skills. In order to do that, we take as theoretical framework the different conceptions of grammar proposed in Travaglia (2009, 2011 and Functional Discourse Grammar (HENGEVELD; MACKENZIE, 2008. This research points to the need to emphasize the cohesive role established by the relative pronoun that introduces the relative clause, to understand the non-restrictive relative clause from its argumentative function and to review the distinction between subtypes of adjective clause from the criteria of omission of the subordinate clause.

  18. MD-2 determinants of nickel and cobalt-mediated activation of human TLR4.

    Directory of Open Access Journals (Sweden)

    Alja Oblak

    Full Text Available Recent findings unexpectedly revealed that human TLR4 can be directly activated by nickel ions. This activation is due to the coordination of nickel by a cluster of histidine residues on the ectodomain of human TLR4, which is absent in most other species. We aimed to elucidate the role of MD-2 in the molecular mechanism of TLR4/MD-2 activation by nickel, as nickel binding site on TLR4 is remote from MD-2, which directly binds the endotoxin as the main pathological activator of TLR4. We identified MD-2 and TLR4 mutants which abolished TLR4/MD-2 receptor activation by endotoxin but could nevertheless be significantly activated by nickel, which acts in synergy with LPS. Human TLR4/MD-2 was also activated by cobalt ions, while copper and cadmium were toxic in the tested concentration range. Activation of TLR4 by cobalt required MD-2 and was abolished by human TLR4 mutations of histidine residues at positions 456 and 458. We demonstrated that activation of TLR4 by nickel and cobalt ions can trigger both the MyD88-dependent and the -independent pathway. Based on our results we propose that predominantly hydrophobic interactions between MD-2 and TLR4 contribute to the stabilization of the TLR4/MD-2/metal ion complex in a conformation that enables activation.

  19. Analysis and Transformation Tools for Constrained Horn Clause Verification

    DEFF Research Database (Denmark)

    Kafle, Bishoksan; Gallagher, John Patrick

    2014-01-01

    is to investigate the use of a combination of off-the-shelf techniques from the literature in analysis and transformation of Constraint Logic Programs (CLPs) to solve challenging CHC verification problems. We find that many problems can be solved using a combination of tools based on well-known techniques from......Several techniques and tools have been developed for verification of properties expressed as Horn clauses with constraints over a background theory (CHC). Current CHC verification tools implement intricate algorithms and are often limited to certain subclasses of CHC problems. Our aim in this work...... abstract interpretation, semantics-preserving transformations, program specialisation and query-answer transformations. This gives insights into the design of automatic, more general CHC verification tools based on a library of components....

  20. Role of toluene in hydrogen sulfide combustion under Claus condition

    International Nuclear Information System (INIS)

    Highlights: • Examined the role of toluene addition in hydrogen sulfide combustion. • Effect of 0%, 0.5%, 1% and 5% of toluene in H2S gas stream was examined. • Toluene addition triggers production of H2 which provides oxidation competition to H2S. • Increased amount of toluene in H2S gas reduced SO2 and increased asymptotic value of H2S. • Toluene addition enhanced the formation of CO and COS. - Abstract: Experimental investigations on the effect of different amounts of toluene addition to H2S combustion in oxygen under Claus condition (Φ = 3) are presented. Three toluene concentrations of 0.5%, 1% and 5% in H2S are presented and compared with the baseline case of 100% H2S oxygen combustion. Temperature data showed that addition of toluene to H2S gas stream increases the flame temperature because of large heating value associated with toluene. Addition of toluene resulted in the production of H2, which increased with increase in the amounts of toluene addition. Furthermore, increased addition of toluene concentration increased the asymptotic minimum value of hydrogen sulfide due to oxidation competition between the formed H2 and H2S. The results also showed that the presence of CO triggers the formation of COS with toluene addition due to reaction of CO with SO2. The results showed that SO2 mole fraction increased to a maximum value then decayed with distance along the reactor. Addition of toluene increased the rate of SO2 decay. These results have direct impact on sulfur capture in the Claus reactor and its performance

  1. Iterative redundant encryption based on MD5 algorithm%基于MD5的迭代冗余加密算法

    Institute of Scientific and Technical Information of China (English)

    王津涛; 覃尚毅; 王冬梅

    2007-01-01

    MD5报文摘要算法是一种非常流行的加密方案,是对任意长度的消息提取数字指纹或消息摘要的算法,但是,在计算上难以提供两个具有相同数字指纹的不同消息,并难以由给定的数字指纹推算出相应的消息.基于MD5的迭代冗余加密算法对MD5算法进行了扩展,利用了MD5算法的强大安全性,实现了文件加密、解密和数据完整性保护的功能.

  2. MD5算法的过程分析及其C#实现%Process Analysis of MD5 Algorithm and Its C# realization

    Institute of Scientific and Technical Information of China (English)

    杜昌钰

    2008-01-01

    文章对MD5即"Message-Digest Algorithm 5(报文流行的C#对8D5算法进行了具体的实现,给出了一个具体的C#加密实例.虽然MD5因王小云教授在2004国际密码学会议(Crypto'2004)上发表的论文受到了前所未有的冲击,但MD5在一些非关键领域应用还是相当广泛.最后还提出了一些针对MD5现状的解决对策和建议.

  3. ASP网站用户帐号的MD5加密技术%The Encryption Techniques of MD5 about User Accounts in ASP Web

    Institute of Scientific and Technical Information of China (English)

    田文艳

    2007-01-01

    本文介绍了Asp中的MD5(Message-Digest Algorithm 5)加密技术,分析了它的工作原理及使用过程,并通过具体的使用实例,说明了MD5加密技术在网站开发中的具体实现方法.

  4. A super-high throughput implementation of MD5 algorithm on FPGA%超高吞吐量MD5算法的FPGA实现

    Institute of Scientific and Technical Information of China (English)

    王臣; 袁焱

    2011-01-01

    In this paper, a novel architecture is proposed to increase the performance of MD5 computing in FPGA , which can achieve a super-high throughput. The scheme is based on full-pipeline for MD5 implementation. Moreover, FIFO cache structure is used for data storage and cooperative computing. The results of simulation and implementation show that the scheme can achieve the theoretical upper bound on throughput. And based on the same platform of FPGA, it outperforms the published scheme with best performance in terms of 77% higher throughput.%为了提高MD5算法在FPGA中实现的运算效率,使之达到超高的数据吞吐量,提出了一种新的全流水线架构,用于实现MD5算法.架构中使用了FIFO缓存存储数据,以配合流水线的运算.实验验证其达到了单个MD5运算单元运算吞吐量的理论上限,在相同芯片平台上,超过已发表的MD5运算模块最高吞吐量的77%.

  5. Design of MD5 High-Speed Models on FPGA%基于FPGA的MD5高速处理模型设计

    Institute of Scientific and Technical Information of China (English)

    韩津生; 林家骏; 叶建武; 周文锦

    2012-01-01

    In order to improve the performance of MD5 on FPGA, the design concept based on dataflow was proposed. At the design phase, it can assess effectively the specific FPGA, the expected system performance and the specific complex algorithms. Three models of MD5 round were put forward and one of the models was chosen to do experiment. The experimental results indicate that the designed MD5 algorithm could increase efficiently the throughput up to 66. 56 Gbit/s.%为提高MD5的处理速度,提出了基于数据流的设计思想.该思想在设计阶段可以对特定的FPGA、预期的系统性能、复杂的专用算法等进行有效评估.基于该思想,提出了3种不同的MD5节点模型.通过分析,对其中1种模型进行实验,实验验证了基于数据流的设计思想能有效提高MD5的吞吐量,达到66.56 Gbit/s.

  6. 一种使MD5算法产生更强雪崩效应的方法%Generating stronger avalanche effect in MD5 algorithm

    Institute of Scientific and Technical Information of China (English)

    张鑫彦; 闫德勤

    2010-01-01

    通过研究不同的差分分析对MD5算法的攻击后发现,差分分析攻击之所以可以成功,是因为在MD5算法中改变了明文中一些特定位,而这些特定位的改变在许多轮中最多只影响链接变量的几个位,并且这些小的差分能在随后的多轮操作中得到纠正,从而产生了碰撞.这就说明原MD5算法的雪崩效应不能阻止差分分析的攻击,而为了提高MD5算法的安全性,必须提高其雪崩效应的敏感性.分析结果表明,用动态明文变化函数对MD5算法进行修改,能使其产生更敏感的雪崩效应,以此来有效防止差分分析攻击,提高MD5算法的安全性.

  7. 78 FR 59060 - Gabriel Sanchez, M.D.; Decision and Order

    Science.gov (United States)

    2013-09-25

    ... any compression of the nerves, or the spinal column, or the nerve root,'' and that it was ``difficult... sufficiently reliable to be accepted and relied upon in this .'' See Cynthia M. Cadet, M.D., 76 FR 19450, 19458... factors are . . . considered in the disjunctive.'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003)....

  8. Measurement of Delta-md Using a Probability Based Same-Side Tagger at CDF

    OpenAIRE

    Bauer, G

    2000-01-01

    A measurement of Delta m_d is performed using inclusive lepton+vertex events at CDF. A probability based Same-Side Tagger was developed to tag the initial b-flavor of the B^0_d, which suppresses tagging on B-decay products. We find Delta m_d = 0.42 +/- 0.09 +/- 0.03 ps^-1.

  9. 75 FR 21528 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Science.gov (United States)

    2010-04-26

    ... Policies and Procedures (44 FR 11034, February 26, 1979), and 3. Will not have a significant economic... have the same design as those installed on Model MD-90-30 airplanes. Therefore, Model MD-90-30..., hangar lighting, flashlight, or ] droplight and may require removal or opening of access panels or...

  10. 77 FR 67673 - Fernando Valle, M.D.; Decision and Order

    Science.gov (United States)

    2012-11-13

    ... DEA registration. Serenity Caf , 77 FR 35027, 35028 (2012); David W. Wang, 72 FR 54297, 54298 (2007); Sheran Arden Yeates, 71 FR 39130, 39131 (2006); Dominick A. Ricci, M.D., 58 FR 51104 (1993); Bobby Watts, M.D., 53 FR 11919 (1988). Notwithstanding the foregoing, the Respondent contends that the...

  11. DNA methylation fluctuation induced by virus infection differs between MD-resistant and -susceptible chickens

    Science.gov (United States)

    Marek’s disease (MD) is a lymphoproliferative disease induced by Marek’s disease virus (MDV). To augment vaccination, the host genetic resistance is of importance in MD control. While researchers have been largely focused on exploring the genetic differences between resistant and susceptible chicken...

  12. 33 CFR 110.71 - Jacobs Nose Cove, Elk River, Md.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Jacobs Nose Cove, Elk River, Md... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.71 Jacobs Nose Cove, Elk River, Md. The water area of Jacobs Nose Cove, on the west side of the mouth of Elk River, Maryland, comprising the...

  13. Accusative resumptive pronoun in the Czech relative clauses with absolute relativizer co

    Czech Academy of Sciences Publication Activity Database

    Fried, Mirjam

    2010-01-01

    Roč. 1, č. 1 (2010), s. 16-29. ISSN 1804-137X Institutional research plan: CEZ:AV0Z90610518 Keywords : relative clauses * relativizer * resumptive pronoun * corpus analysis Subject RIV: AI - Linguistics

  14. Transport and characterization of ambient biological aerosol near Laurel, MD

    Directory of Open Access Journals (Sweden)

    J. L. Santarpia

    2010-09-01

    Full Text Available Bacterial aerosol have been observed and studied in the ambient environment since the mid nineteenth century. These studies have sought to provide a better understanding of the diversity, variability and factors that control the biological aerosol population. In this study, we show comparisons between diversity of culturable bacteria and fungi, using culture and clinical biochemical tests, and 16S rRNA diversity using Affymetrix PhyloChips. Comparing the culturable fraction and surveying the total 16S rRNA of each sample provides a comprehensive look at the bacterial population studied and allows comparison with previous studies. Thirty-six hour back-trajectories of the air parcels sampled, over the two day period beginning 4 November 2008, provide information on the sources of aerosol sampled on the campus of Johns Hopkins University Applied Physics Laboratory in Laurel, MD. This study indicates that back-trajectory modeling of air parcels may provide insights into the observed diversity of biological aerosol.

  15. The MD simulation of thermal properties of plutonium dioxide

    International Nuclear Information System (INIS)

    The thermodynamic properties of PuO2 have been investigated between 300 and 3000 K by molecular dynamics (MD) simulation with empirical interaction potential. The properties include melting point, lattice parameter variation, enthalpy and heat capacity. The melting point of two-phase simulation (TPS) is in agreement with the experimental value, and it gives a much lower value than one-phase simulation (OPS). The lattice parameter and heat capacity at high temperatures are expressed as a(T)=5.38178+4.38×10-5T+6.5525×10-9T2+0.9362×10-12T3 and CP(KJ⋅mol-1⋅K-1)=18648.8e474.5/T/(T2(e474.5/T-1)2)+9.337×10-6T, respectively. True linear thermal expansion coefficient (TLTEC) α is about 8.89×10-6 K-1 at 300 K. Our simulation results are in good agreement with experimental and other theoretical data.

  16. John Call Dalton, Jr., MD: America's first neurophysiologist.

    Science.gov (United States)

    Fine, E J; Manteghi, T; Sobel, S H; Lohr, L A

    2000-09-26

    Before the discoveries of John Call Dalton, Jr., MD (1824-1889), innervation of laryngeal muscles, long-term effects of cerebellar lesions, and consequences of raised intracranial pressure were poorly understood. Dalton discovered that the posterior cricoarytenoid muscles adducted the vocal cords during inspiration. He confirmed Flourens' observations that acute ablation of the cerebellum of pigeons caused loss of coordination. Dalton observed that properly cared for pigeons gradually recovered "coordinating power." Dalton observed that prolonged raised intracranial pressure caused tachycardia and then fatal bradycardia in dogs. Before Dalton published his photographic atlas of the human brain, neuroanatomy atlases were sketched by Europeans and imported into the United States. Dalton's atlas of the human brain contained precise photographs of vertical and horizontal sections that equal modern works. Before Dalton introduced live demonstrations of animals, physiology was taught by recitation of texts only. Dalton was the first American-born professor to teach physiology employing demonstrations of live animals operated on under ether anesthesia. He wrote an essay advocating experimentation on animals as the proper method of acquiring knowledge of function and that humane animal experimentation would ultimately improve the health of man and animals. His eloquent advocacy for humane experimental physiology quelled attacks by contemporaneous antivivisectionists. Dalton was America's first experimental neurophysiologist. PMID:10994009

  17. Considerations concerning the criminal clause, expression of contractual principle and law abuse

    OpenAIRE

    Nora Andreea Daghie

    2009-01-01

    The criminal clause is an accessory convention through which the parts evaluate in advance the prejudiceinterestswhich come from the inexecution lato sensu of the contractual obligations. This convention named criminalclause is the expression of the contractual liberty principle and presents a singular practical utility but also someinconveniences. Thus the criminal clause allows avoiding the difficulties of judicial evaluation of prejudices-interests.In this way, the creditor is not obliged ...

  18. 12 CFR 591.5 - Limitation on exercise of due-on-sale clauses.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Limitation on exercise of due-on-sale clauses. 591.5 Section 591.5 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY PREEMPTION OF STATE DUE-ON-SALE LAWS § 591.5 Limitation on exercise of due-on-sale clauses. (a) General. Except as provided in § 591.4 (c) and (d)(4)...

  19. Labor clauses in regional trade agreements and effects on labor conditions : an empirical analysis

    OpenAIRE

    KAMATA Isao; 鎌田, 伊佐生

    2016-01-01

    An increasing number of bilateral or plurilateral trade agreements (or regional trade agreements: RTAs) include "labor clauses" that require or urge the signatory countries to commit to maintaining a certain level of labor standards. This paper performs an empirical analysis of the impacts of such labor clauses provided in RTAs on working conditions that laborers in the RTA signatory countries actually face, using macro-level data for a wide variety of countries. The paper first examines the ...

  20. Supreme Court to hear ADA suit involving arbitration clause.

    Science.gov (United States)

    1998-03-20

    The U.S. Supreme Court agreed to review a third case under the Americans with Disabilities Act (ADA) this year. The Supreme Court previously agreed to hear [name removed] v. [Name removed], involving a dentist who refused to treat an HIV-positive patient in his office. The second case is Pennsylvania Department of Corrections v. [Name removed], in which the State asserts that the ADA does not apply to prisons. The third involves whether an arbitration clause in a labor union's collective bargaining agreement prevents a court from hearing a union member's discrimination claim. [Name removed] longshoreman [name removed] alleges that the [name removed] and several employers violated the ADA when they refused to help him for employment referral. [Name removed] previously settled a workers' compensation disability claim with [name removed] and Terminal Co., his employer. Three years later he applied for work at the International Longshoreman's Association hiring hall and was referred to four different employers. The employers discovered he had received a worker's compensation settlement and would no longer accept [name removed] for employment referral. The case is important because union members can continue to file ADA charges with the EEOC and the outcomes will vary depending on the circuit where the union member happens to file the claim. PMID:11365192

  1. 基于MD5的可逆无冗余加密算法%The Reversible Non-Redundant Encryption Algorithm Based on MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    陈钧; 刘爱华

    2012-01-01

    If MD5 algorithm is directly used to encrypt sensitive data in database, the data is unable to be deerypted by this algorithm itself, even legitimate users query or update some data for the purpose of restoring data. The database becomes more redundant because secret keys need to be saved for reversible encryption algorithms. This paper proposes a reversible non-redundant encryption algorithm based on MD5 algorithm, which can be ~ to used encrypt and decrypt sensitive data in the database regardless of saving secret keys.%直接采用MD5算法对数据库中的敏感数据加密时,合法用户进行查询、更新等操作需要还原数据,MD5算法无法解密数据.可逆的加密算法都需要保存密钥,数据库增加了数据的冗余.本文提出一种基于MD5算法的可逆无冗余算法,实现对数据库中敏感数据进行加密、解密,而且不需要保存密钥.

  2. 木质素模型化合物香草醛Mannich反应及其产物化学结构表征%Mannich Reaction of Lignin Model Compound Vanillin and Chemical Structure Characterization of Its Product

    Institute of Scientific and Technical Information of China (English)

    聂明才; 孔振武; 霍淑平; 吴国民; 陈健

    2012-01-01

    Vanillin aminated polyol(VAP) was prepared by vanillin, diethanolamine and paraformaldehyde in 1,4-dioxane by Mannich reaction. The effects of material ratio, reaction temperature, reaction time and solvent dosage on the Mannich reaction were investigated. It was observed the highest conversion rate of diethanolamine was up to 84.92 % by dropping 1,3-oxazolidine which was the reaction product of formaldehyde and diethanolamine at 60℃ for 2 h, into vanillin and reacting at 80 ℃ for 3 h in the molar ratio of n( vanillin) : n( formaldehyde) : n(diethanolamine) as 1 : 1 : 1 in 1,4-dioxane of 100 mL/mol vanillin. The chemical structure of vanillin aminated polyol was characterized by HPLC, LC-MS, FT-IR and 'H NMR, respectively.%以木质素模型化合物香草醛、二乙醇胺及多聚甲醛为原料,1,4-二氧杂环己烷为溶剂,通过Mannich反应合成了香草醛胺基多元醇,研究了物料配比、反应温度、时间及溶剂用量等因素对Mannich反应的影响.实验结果表明:反应物料按物质的量比n(香草醛):n(甲醛):n(二乙醇胺)1:1:1,甲醛与二乙醇胺60℃反应2h生成1,3-氧氮杂环戊烷,再将其滴入香草醛中,80℃反应3h,二氧六环溶剂用量为100 mL/mol(以香草醛的物质的量计),二乙醇胺的转化率最高可达到84.92%.采用HPLC、LC- MS、FT-IR及H NMR表征了香草醛胺基多元醇的化学结构,相对分子质量269.

  3. MD5算法及在用户口令加密应用中的改进%The Improved MD5 Algorithm in the Encryption of User Passwords

    Institute of Scientific and Technical Information of China (English)

    高洪波; 马素萍

    2010-01-01

    MD5是一种非常优秀的加密算法,曾被大量公司和个人广泛使用.但随着科学技术的发展,MD5牢不可破的神话逐渐破灭.基于此,在分析MD5加密算法及其弱点的前提下,探讨了MD5的改进算法.

  4. The Design of MD5 Algorithm against Exhaustion Code-breaking and Its Realization%MD5算法防穷举(冲撞)破译的设计及其实现

    Institute of Scientific and Technical Information of China (English)

    廖思周

    2006-01-01

    在对MD5算法做简单介绍的基础上,针对攻击者拥有巨大密码字典、原文/密文对照数据库,设计了MD5变换算法,是对现有的MD5算法的延伸,大大提高了现成MD5密文的安全性.

  5. Characterization of an Autophagy-related Gene MdATG8i from apple

    Directory of Open Access Journals (Sweden)

    Ping eWang

    2016-05-01

    Full Text Available Nutrient deficiencies restrict apple (Malus sp. tree growth and productivity in Northwest China. The process of autophagy, a conserved degradation pathway in eukaryotic cells, has important roles in nutrient-recycling and helps improve plant performance during periods of nutrient-starvation. Little is known about the functioning of autophagy-related genes (ATGs in apple. In this study, one of the ATG8 gene family members MdATG8i was isolated from M. domestica. MdATG8i has conserved putative tubulin binding sites and ATG7 interaction domains. A 1865-bp promoter region cloned from apple genome DNA was predicated to have cis-regulatory elements responsive to light, environmental stresses and hormones. MdATG8i transcriptions were induced in response to leaf senescence, nitrogen depletion, and oxidative stress. At cellular level, MdATG8i protein was expressed in the nucleus and cytoplasm of onion epidermal cells. Yeast two-hybrid tests showed that MdATG8i could interact with MdATG7a and MdATG7b. In Arabidopsis, its heterologous expression was associated with enhanced vegetative growth, leaf senescence, and tolerance to nitrogen- and carbon-starvation. MdATG8i-overexpressing ‘Orin’ apple callus lines also displayed improved tolerance to nutrient-limited conditions. Our results demonstrate that MdATG8i protein could function in autophagy in a conserved way, as a positive regulator in the response to nutrient-starvation.

  6. Binding Third Parties to Maritime Arbitration, Incorporation of Charterparty Arbitration Clause into Bill of Lading by Reference

    OpenAIRE

    Tchkuaseli, Rusudan

    2013-01-01

    Arbitration is consensual by nature. Therefore, arbitration agreement is usually binding on the parties privy to the contract containing the arbitration clause. Nevertheless, general principles of contract law allow for extension of an arbitration clause to third parties only if free, knowing and complete consent of such party to arbitrate is established. It is difficult to tailor this rule to the situation when a bill of lading issued under a charterparty contains a reference clause, which b...

  7. MD5优化算法及安全性分析%Analysis of MD5 Optimization Algorithm and Safety

    Institute of Scientific and Technical Information of China (English)

    张双斌

    2009-01-01

    针对目前MD5基本算法加密结果容易被破解的问题,在研究分析MD5、SHA-1及其系列算法加密原理的基础上,提出一种增加消息摘要长度的优化算法,使得破解时碰撞的概率减少很多倍,增强了系统加密的安全性.安全分析结果表明,MD5优化算法在保留了原算法加密速度的前提下,具有较原算法更好的抗攻击能力.

  8. A High Throughput FPGA Implementation of MD5 Algorithm%一种高吞吐量MD5算法的FPGA实现

    Institute of Scientific and Technical Information of China (English)

    刘凯; 车明; 秦存秀

    2008-01-01

    MD5数字摘要算法在网络安全的诸多方面都得到广泛的应用.由于其串行计算的特点,对MD5算法的加速并不像其它具有并行操作算法那样容易实现.提出了采用4级流水线的结构来提高MD5运算的吞吐量,可以提升至吉比特级.在设计中,参考了分布式存储模型的结构来实现低延迟、低资源消耗及更好的可扩展性.

  9. Application of MD5 Algorithm in Office Automation System%MD5算法在办公自动化系统中的应用

    Institute of Scientific and Technical Information of China (English)

    张智发

    2008-01-01

    该文对办公自动化系统面临的风险进行了分析,介绍了MD5算法的特点和原理,把MD5算法应用于办公自动化系统中,解决了密码保护、信息完整性验证和数字签名等安全问题, 并给出了具体实现方法.

  10. HMAC-MD5的 FPGA 优化与实现%FPGA Optimization and Implementation of HMAC-MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    蔡啸; 李树国

    2015-01-01

    Data integrity and authenticity are very important in field of information security.HMAC-MD5 algorithm is one of the algorithms that achieve this target.The performance of its software implementation is very low and its FPGA hardware implementation is much higher.For the sake of higher throughput,this paper propose a two-to-one structure.As the result,it costs only 33 cycles to process 5 12 bits data.At the same time,the design support three kinds of mode:HMAC-MD5 computation with Key,HMAC-MD5 computation without key,MD5 computation. The design contains many optimization strategies such as pre-computation, microinstruction controller, the resources reuse etc.After synthesizing by Quartus II 13.0 on Stratix III devices,the clock frequency reaches 100 MHz,the throughput reaches 1.55 Gb/s and 1 120 ALUTs logic resources have been used.%在信息安全领域,数据完整性和真实性是十分重要的.HMAC-MD5算法是实现数据完整性和真实性验证的一种算法.HMAC-MD5的软件实现性能较低,而它的 FPGA 硬件实现性能较高.为了提高 FPGA 实现的性能,提出了一种二合一的结构,处理512 bit 数据周期数降低至33拍,提高了吞吐率,同时能够支持 HMAC-MD5带密钥输入和不带密钥输入、单 MD5运算的模式选择.本设计在 Stratix III 器件上使用 QuartusII 13.0进行综合,在使用了预计算、微指令控制器、资源复用等优化策略之后,最终综合出时钟频率为100 MHz,吞吐率达到1.55 Gb/s,逻辑资源使用为1120 ALUTs.

  11. Authentication in Networking Environment Based on LECC and MD5 Algorithm%基于LECC和MD5算法的网络身份认证

    Institute of Scientific and Technical Information of China (English)

    王小冬; 周海燕

    2015-01-01

    MD5算法常用于对远程用户进行身份认证,但其抵挡不了查字典或差分攻击.本文对用户身份进行MD5加密后,再采用LECC对密文进行纠错编码,提高算法抵御防攻击的能力.理论和实践证明,本算法具有较高的安全性和实用价值.

  12. Milestone report on MD potential development for uranium silicide

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Jianguo [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.; Zhang, Yongfeng [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.; Hales, Jason Dean [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.

    2016-03-01

    This report summarizes the progress on the interatomic potential development of triuranium-disilicide (U3Si2) for molecular dynamics (MD) simulations. The development is based on the Tersoff type potentials for single element U and Si. The Si potential is taken from the literature and a Tersoff type U potential is developed in this project. With the primary focus on the U3Si2 phase, some other U-Si systems such as U3Si are also included as a test of the transferability of the potentials for binary U-Si phases. Based on the potentials for unary U and Si, two sets of parameters for the binary U-Si system are developed using the Tersoff mixing rules and the cross-term fitting, respectively. The cross-term potential is found to give better results on the enthalpy of formation, lattice constants and elastic constants than those produced by the Tersoff mixing potential, with the reference data taken from either experiments or density functional theory (DFT) calculations. In particular, the results on the formation enthalpy and lattice constants for the U3Si2 phase and lattice constants for the high temperature U3Si (h-U3Si) phase generated by the cross-term potential agree well with experimental data. Reasonable agreements are also reached on the elastic constants of U3Si2, on the formation enthalpy for the low temperature U3Si (m-U3Si) and h-U3Si phases, and on the lattice constants of m-U3Si phase. All these phases are predicted to be mechanically stable. The unary U potential is tested for three metallic U phases (α, β, γ). The potential is found capable to predict the cohesive energies well against experimental data for all three phases. It matches reasonably with previous experiments on the lattice constants and elastic constants of αU.

  13. 芳香酮曼尼希碱酸化缓蚀剂的合成及复配研究%Synthesis and complex of the corrosion inhibitor of mannich bases of aromatic ketones

    Institute of Scientific and Technical Information of China (English)

    王霞; 白媛丽; 罗全民; 刘志辉

    2012-01-01

    37% Formaldehyde solution,acetophenone and diethylamine were chosed ultimately and these materials compounded a new type of mannich base hydrochloride acid inhibitor, and its complex research. The results showed that the best synthetic process conditions is diethylamine, formaldehyde, acetophenone molar ratio is:2:2:1 .reaction time is 8 h,reaction temperature is 80℃,,reaction system pH value is 4. Sodi-um tungstate and corrosion inhibitor have a positive synergies, potassium iodide negative synergistic effect.%以37%的甲醛溶液、苯乙酮和二乙胺为原料,合成一种新型曼尼希碱盐酸酸化缓蚀剂,并对其进行复配研究.结果表明,最佳合成条件为:二乙胺、37%甲醛溶液和苯乙酮的摩尔比为2:2:1,反应时间8h,反应温度80 ℃,pH值为4;钨酸钠和缓蚀剂有着很好的正协同效应,碘化钾与其有负协同效应.

  14. Synthesis of Mannich Base by One-pot Method with Aromatic Aldehyde, Acetophenone and p-Nitroaniline%芳香醛、苯乙酮和对硝基苯胺一锅法合成Mannich碱

    Institute of Scientific and Technical Information of China (English)

    温俏; 李小花; 林春秀; 徐达; 刘春玲

    2015-01-01

    在浓盐酸做催化剂的条件下,芳香醛、苯乙酮和对硝基苯胺能够发生Mannich反应,经过提纯得到相应的Mannich碱。用红外光谱对产物的结构进行表征,并研究浓盐酸的使用量、反应温度、反应时间等条件对产率的影响。实验发现在3滴浓盐酸催化下,控温在15~20℃,反应20 h,产率可达60%左右。%The Mannich base were synthesized by one-pot method with aromatic aldehyde, acetophenone and p-nitroaniline in concentrated hydrochloric acid. The structural properties of the products were characterized by IR spectrum. The influence of the factors of the quantity of catalyst, the reaction time and temperature on the product yield was systematically studied. It was found that under the conditions of 3 drops of concentrated hydrochloric acid as catalysis, in 15~20 ℃ and for 20 h, the production rate can reach 60%.

  15. A Mathematic Model That Describes Modes of MdSGHV Transmission within House Fly Populations

    Directory of Open Access Journals (Sweden)

    Celeste R. Vallejo

    2013-11-01

    Full Text Available In this paper it is proposed that one potential component by which the Musca domestica salivary gland hypertrophy virus (MdSGHV infects individual flies is through cuticular damage. Breaks in the cuticle allow entry of the virus into the hemocoel causing the infection. Male flies typically have a higher rate of infection and a higher rate of cuticular damage than females. A model for the transmission of MdSGHV was formulated assuming several potential and recognized means of transmission. The model yields results that are in agreement with field data that measured the infection rate in house flies on dairy farms in Florida. The results from this model indicate that MdSGHV will be maintained at a stable rate within house fly populations and support the future use of MdSGHV as a birth control agent in house fly management.

  16. A Mathematic Model That Describes Modes of MdSGHV Transmission within House Fly Populations.

    Science.gov (United States)

    Vallejo, Celeste R; Lee, Jo Ann; Keesling, James E; Geden, Christopher J; Lietze, Verena-Ulrike; Boucias, Drion G

    2013-01-01

    In this paper it is proposed that one potential component by which the Musca domestica salivary gland hypertrophy virus (MdSGHV) infects individual flies is through cuticular damage. Breaks in the cuticle allow entry of the virus into the hemocoel causing the infection. Male flies typically have a higher rate of infection and a higher rate of cuticular damage than females. A model for the transmission of MdSGHV was formulated assuming several potential and recognized means of transmission. The model yields results that are in agreement with field data that measured the infection rate in house flies on dairy farms in Florida. The results from this model indicate that MdSGHV will be maintained at a stable rate within house fly populations and support the future use of MdSGHV as a birth control agent in house fly management. PMID:26462530

  17. 75 FR 49979 - Tony T. Bui, M.D.; Revocation of Registration

    Science.gov (United States)

    2010-08-16

    ....'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003). I ``may rely on any one or a combination of factors... girlfriend admitting to a soft- drink adulteration that never occurred.'' Id. at 32. Moreover, even after...

  18. 76 FR 52865 - Special Local Regulations for Marine Events; Patuxent River, Solomons, MD

    Science.gov (United States)

    2011-08-24

    ... Marine Events; Patuxent River, Solomons, MD'' in the Federal Register (76 FR 118). We received no... Solomon's Pier. A large spectator fleet is expected during the event. Due to the need for vessel...

  19. Clause/Term Resolution and Learning in the Evaluation of Quantified Boolean Formulas

    CERN Document Server

    Giunchiglia, E; Tacchella, A; 10.1613/jair.1959

    2011-01-01

    Resolution is the rule of inference at the basis of most procedures for automated reasoning. In these procedures, the input formula is first translated into an equisatisfiable formula in conjunctive normal form (CNF) and then represented as a set of clauses. Deduction starts by inferring new clauses by resolution, and goes on until the empty clause is generated or satisfiability of the set of clauses is proven, e.g., because no new clauses can be generated. In this paper, we restrict our attention to the problem of evaluating Quantified Boolean Formulas (QBFs). In this setting, the above outlined deduction process is known to be sound and complete if given a formula in CNF and if a form of resolution, called Q-resolution, is used. We introduce Q-resolution on terms, to be used for formulas in disjunctive normal form. We show that the computation performed by most of the available procedures for QBFs --based on the Davis-Logemann-Loveland procedure (DLL) for propositional satisfiability-- corresponds to a tree...

  20. Considerations concerning the criminal clause, expression of contractual principle and law abuse

    Directory of Open Access Journals (Sweden)

    Nora Andreea Daghie

    2009-06-01

    Full Text Available The criminal clause is an accessory convention through which the parts evaluate in advance the prejudiceinterestswhich come from the inexecution lato sensu of the contractual obligations. This convention named criminalclause is the expression of the contractual liberty principle and presents a singular practical utility but also someinconveniences. Thus the criminal clause allows avoiding the difficulties of judicial evaluation of prejudices-interests.In this way, the creditor is not obliged to evidence the existence and the size of the prejudice, in order to obtain thepayment of the amount of money or carrying out other patrimonial value established in the criminal clause beingsufficient the proof of non inexecution lato sensu of the contractual obligation. The criminal clause has also a strongcomminatory purpose, exercising a pressure on the debtor to make all possible to execute precisely the contractualobligation. Due to these reasons it is seen in doctrine by some of the authors as one of the main guarantees in our law.Also in the doctrine however, it is shown that the debtor can be constrained in some situations to accept establishing avery high amount in the criminal clause, sometimes with inequitable consequences, with damaging effect for thedebtor.

  1. An audit questionnaire that examines specifically the management of technical activities clauses in ISO 15189.

    Science.gov (United States)

    Hartley, T F

    2010-01-01

    The aim of this study was to design an audit questionnaire that focuses on the management of the technical activities in a Diagnostic Pathology Laboratory. The ISO 15189 Standard is written in such a way that it continually moves back and forth from topics where the auditor needs to question bench level staff, to topics where the auditor needs to question Technical Management Staff. This makes for a disjointed audit process - both Bench Staff and Technical Managers are repeatedly interrupted. The solution was to do a clause by clause analysis of the Standard and assign the major responsibility for the compliance to each clause to either Technical Managers or Bench Staff. The Clauses were then grouped under four topic headings regardless of whether they were a Section 4 or Section 5 Clause. Two questionnaires have emerged - the one described in this work and one directed primarily towards the activities of bench staff. There are 95 questions and it takes approximately two hours to complete. PMID:23105892

  2. Summary of LHC MD 369: DOROS vs WBTN in IR Stripline BPMs

    CERN Document Server

    Draskovic, Drasko; Calvo Giraldo, Eva; Olexa, Jakub; Gasior, Marek; CERN. Geneva. ATS Department

    2015-01-01

    The aim of this MD is to quantify the impact of the stripline beam position monitor (BPM) directivity with two acquisition chain electronics systems, WBTN (Wide Band Time Normalizer) and DOROS (Diode ORbit and Oscillation System). This impact depends on the relative position and intensity of the two beams at the location of the monitor. This note explains all the procedures of the LHC MD 369, which took place on 20/07/2015 and presents the obtained results.

  3. EMC/FDTD/MD simulation of carrier transport and electrodynamics in two-dimensional electron systems

    OpenAIRE

    Sule, N; Willis, K. J.; Hagness, S. C.; Knezevic, I.

    2014-01-01

    We present the implementation and application of a multiphysics simulation technique to carrier dynamics under electromagnetic excitation in supported two-dimensional electronic systems. The technique combines ensemble Monte Carlo (EMC) for carrier transport with finite-difference time-domain (FDTD) for electrodynamics and molecular dynamics (MD) for short-range Coulomb interactions among particles. We demonstrate the use of this EMC/FDTD/MD technique by calculating the room-temperature dc an...

  4. Productive replication of Malacosoma neustria nucleopolyhedrovirus (ManeNPV) in Md203 cell line

    OpenAIRE

    DEMİR, İsmail; GÜREL, Nurten; NALÇACIOĞLU, Remziye; İNCE, İkbal A.; DEMİRBAĞ, Zihni

    2009-01-01

    A plaque-purified genotypic variant, derived from a field isolate of the Malacosoma neustria nucleopolyhedrovirus (ManeNPV) from Turkey was characterized based on in vitro replication properties in a cell line, Md203 derived from Malacosoma disstria. The life cycle of ManeNPV was studied based on the cytopathic effects (CPEs), polyhedral inclusion body (PIB) formation, budded virus (BV) production, viral DNA replication and polyhedrin protein expression in ManeNPV-infected Md203 cells. Infec...

  5. MD-CTS: An integrated terminology reference of clinical and translational medicine

    OpenAIRE

    Ray, Will; Finamore, Joe; Rastegar-Mojarad, Majid; Kadolph, Chris; Ye, Zhan; Bohne, Jacquie; Xu, Yin; Burish, Dan; Sondelski, Joshua; Easker, Melissa; Finnegan, Brian; Bartkowiak, Barbara; Smith, Catherine Arnott; Tachinardi, Umberto; Mendonca, Eneida A

    2016-01-01

    New vocabularies are rapidly evolving in the literature relative to the practice of clinical medicine and translational research. To provide integrated access to new terms, we developed a mobile and desktop online reference—Marshfield Dictionary of Clinical and Translational Science (MD-CTS). It is the first public resource that comprehensively integrates Wiktionary (word definition), BioPortal (ontology), Wiki (image reference), and Medline abstract (word usage) information. MD-CTS is access...

  6. Parallel cascade selection molecular dynamics (PaCS-MD) to generate conformational transition pathway

    Science.gov (United States)

    Harada, Ryuhei; Kitao, Akio

    2013-07-01

    Parallel Cascade Selection Molecular Dynamics (PaCS-MD) is proposed as a molecular simulation method to generate conformational transition pathway under the condition that a set of "reactant" and "product" structures is known a priori. In PaCS-MD, the cycle of short multiple independent molecular dynamics simulations and selection of the structures close to the product structure for the next cycle are repeated until the simulated structures move sufficiently close to the product. Folding of 10-residue mini-protein chignolin from the extended to native structures and open-close conformational transition of T4 lysozyme were investigated by PaCS-MD. In both cases, tens of cycles of 100-ps MD were sufficient to reach the product structures, indicating the efficient generation of conformational transition pathway in PaCS-MD with a series of conventional MD without additional external biases. Using the snapshots along the pathway as the initial coordinates, free energy landscapes were calculated by the combination with multiple independent umbrella samplings to statistically elucidate the conformational transition pathways.

  7. A Study of L1 Transfer on the Use of Attributive Clauses In English Writing%A Study of L1 Transfer on the Use of Attributive Clauses In English Writing

    Institute of Scientific and Technical Information of China (English)

    边宛

    2011-01-01

    This study is carried out to find out the role of LI transfer on the problems of attributive clauses. By the application of Contrastive Analysis and Error Analysis, the study shows, Chinese belongs to the left-branching language, while English is the right- branching one in terms of the structure of attributive clauses.

  8. 14 CFR 91.23 - Truth-in-leasing clause requirement in leases and conditional sales contracts.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Truth-in-leasing clause requirement in... OPERATING AND FLIGHT RULES General § 91.23 Truth-in-leasing clause requirement in leases and conditional... January 2, 1973, shall execute a written lease or contract and include therein a written...

  9. 48 CFR 28.311 - Solicitation provision and contract clause on liability insurance under cost-reimbursement...

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Solicitation provision and contract clause on liability insurance under cost-reimbursement contracts. 28.311 Section 28.311 Federal... INSURANCE Insurance 28.311 Solicitation provision and contract clause on liability insurance under...

  10. 48 CFR 528.311 - Solicitation provision and contract clause on liability insurance under cost-reimbursement...

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Solicitation provision and contract clause on liability insurance under cost-reimbursement contracts. 528.311 Section 528.311 Federal... INSURANCE Insurance 528.311 Solicitation provision and contract clause on liability insurance under...

  11. 48 CFR 3028.311 - Solicitation provision and contract clause on liability insurance under cost-reimbursement...

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Solicitation provision and contract clause on liability insurance under cost-reimbursement contracts. 3028.311 Section 3028.311... contract clause on liability insurance under cost-reimbursement contracts....

  12. 48 CFR 328.311 - Solicitation provision and contract clause on liability insurance under cost-reimbursement...

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Solicitation provision and contract clause on liability insurance under cost-reimbursement contracts. 328.311 Section 328.311 Federal... Insurance 328.311 Solicitation provision and contract clause on liability insurance under...

  13. 8 CFR 204.7 - Preservation of benefits contained in savings clause of Immigration and Nationality Act...

    Science.gov (United States)

    2010-01-01

    ... savings clause of Immigration and Nationality Act Amendments of 1976. 204.7 Section 204.7 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRANT PETITIONS Immigrant Visa Petitions § 204.7 Preservation of benefits contained in savings clause of Immigration and Nationality...

  14. Tree automata-based refinement with application to Horn clause verification

    DEFF Research Database (Denmark)

    Kafle, Bishoksan; Gallagher, John Patrick

    rather than just transition systems; secondly, we show how algorithms manipulating tree automata interact with abstract interpretations, establishing progress in refinement and generating refined clauses that eliminate causes of imprecision. We show how to derive a refined set of Horn clauses in which...... given infeasible traces have been eliminated, using a recent optimised algorithm for tree automata determinisation. We also show how we can introduce disjunctive abstractions selectively by splitting states in the tree automaton. The approach is independent of the abstract domain and constraint theory...

  15. Den sene Derrida, eller: Er Claus Beck-Nielsen et spøgelse?

    DEFF Research Database (Denmark)

    Rösing, Lilian Munk

    2009-01-01

    This article is about hosting the ghost. In Spectres de Marx (1993) Derrida introduces the ghost which seems to condense in one figure the important themes of his late writings: the address, the other, the ethical turn, the event, the mourning, the reality of immateriality, the guest. The article...... turns to the paternal ghost from Shakespeare's Hamlet, as well as to the most ghost-like artist on the Danish contemporary art scene: Claus Beck-Nielsen, who some years ago declared himself dead. Is Claus Beck-Nielsen really a ghost? That is the question....

  16. Generation Y and their awareness of the Santa Claus Village in Rovaniemi

    OpenAIRE

    Saarinen, Hanna; Nordström, Tiia

    2015-01-01

    The Santa Claus Village is one of the biggest tourism attractions in Northern Finland, and the city of Rovaniemi has been titled as the “Official Hometown of Santa Claus”. This thesis studies the level of knowledge of the Santa Claus Village and the affect the village has on the incoming tourism in the Rovaniemi. More specifically the focus is on the perceptions of different nationalities and generation Y, as in young adults with no children. The thesis was commissioned by Rovaniemi Touri...

  17. The utility of the rescission clause in the settlement of disputes arising from international trade contracts

    Directory of Open Access Journals (Sweden)

    Oana BĂRBULESCU

    2015-12-01

    Full Text Available Starting from the opportunities that the creditor of an obligation has in order to settle his claims by means of the commercial arbitration, as an alternative to court under common law, with a view to punishing in the most effective way the failure of the obligation by the borrower reveals the necessity to introduce the rescission clause in international commercial contracts governed by a foreign law. This paper aims to emphasize the practical utility of the institution of rescission clause in the light of the new Civil Code regulations, in whose presence the role of the court is entirely removed in as far as the decision statement is concerned.

  18. The Interaction of Most-Favored-Nation (MFN) Clauses With Dispute Settlement Provisions in Investment Treaties : A New Continent to Discover?

    OpenAIRE

    Koch, Alexander

    2007-01-01

    The master thesis provides a comprehensive and comparative analysis of the scope of most-favoured-nation clauses, focusing on the application of such clauses to dispute resolution mechanisms in bilateral investment treaty’s (BIT). The ICSID decision in Maffezini was the first in a series to extend the scope of an MFN clause to dispute resolution in such context. Traditionally, such a clause had been relied on regarding substantive rights. The debate evoked by this and subsequent decisions of ...

  19. Evaluation of hydroacid complex in the forward osmosis–membrane distillation (FO–MD) system for desalination

    KAUST Repository

    Wang, Peng

    2015-11-01

    The incorporation of membrane distillation (MD) into forward osmosis (FO) provides process sustainability to regenerate the draw solution and to produce clean water simultaneously. However, the reverse salt flux is the major hurdle in the FO-MD system because it not only reduces the effective osmotic driving force across the membrane but also increases the replenishment cost and scaling issue. For the first time, a hydroacid complex with abundant hydrophilic groups and ionic species is evaluated as the draw solutes in the hybrid FO-MD system consisting of multi-bore PVDF MD membranes for seawater/brackish desalination. In order to evaluate the practicality of the hydroacid complex in the FO-MD system, FO and MD experiments were conducted at elevated temperatures and concentrations. The hydroacid complex has displayed desired properties such as high solubility, low viscosity, excellent thermal stability and minimal reverse salt flux suitable for FO and MD operations. FO-MD desalination process was demonstrated with a highest seawater desalination flux of 6/32 LMH (FO/MD). This study may open up the prospective of employing the hydroacid complex as the draw solute in FO-MD hybrid systems for seawater /brackish desalination. © 2015 Elsevier B.V.

  20. PuReMD-GPU: A reactive molecular dynamics simulation package for GPUs

    Energy Technology Data Exchange (ETDEWEB)

    Kylasa, S.B., E-mail: skylasa@purdue.edu [Department of Elec. and Comp. Eng., Purdue University, West Lafayette, IN 47907 (United States); Aktulga, H.M., E-mail: hmaktulga@lbl.gov [Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, MS 50F-1650, Berkeley, CA 94720 (United States); Grama, A.Y., E-mail: ayg@cs.purdue.edu [Department of Computer Science, Purdue University, West Lafayette, IN 47907 (United States)

    2014-09-01

    We present an efficient and highly accurate GP-GPU implementation of our community code, PuReMD, for reactive molecular dynamics simulations using the ReaxFF force field. PuReMD and its incorporation into LAMMPS (Reax/C) is used by a large number of research groups worldwide for simulating diverse systems ranging from biomembranes to explosives (RDX) at atomistic level of detail. The sub-femtosecond time-steps associated with ReaxFF strongly motivate significant improvements to per-timestep simulation time through effective use of GPUs. This paper presents, in detail, the design and implementation of PuReMD-GPU, which enables ReaxFF simulations on GPUs, as well as various performance optimization techniques we developed to obtain high performance on state-of-the-art hardware. Comprehensive experiments on model systems (bulk water and amorphous silica) are presented to quantify the performance improvements achieved by PuReMD-GPU and to verify its accuracy. In particular, our experiments show up to 16× improvement in runtime compared to our highly optimized CPU-only single-core ReaxFF implementation. PuReMD-GPU is a unique production code, and is currently available on request from the authors.

  1. Implementation of MD5 Fast Crack Based on GPU Cluster%基于GPU集群实现MD5的快速破解

    Institute of Scientific and Technical Information of China (English)

    杨胜斌

    2013-01-01

    从单个GPU异构并行系统来看,其性能还是比较有限,文章阐述了基于GPU集群的CUDA架构实现过程,详细分析基于GPU集群进行MD5快速破解的编译过程,并对破解程序进行测试研究,对其运行结果进行测试和分析,探讨搭建GPU高性能计算集群及其进行MD5算法的快速破解的过程.

  2. Children's Processing of Ambiguous Sentences: A Study of Relative Clause Attachment

    Science.gov (United States)

    Felser, Claudia; Marinis, Theodore; Clahsen, Harald

    2003-01-01

    In this study, we investigate children's and adults' relative clause attachment preferences in sentences such as "The student photographed the fan of the actress who was looking happy." Twenty-nine 6- to 7-year-old monolingual English children and 37 adult native speakers of English participated both in an auditory questionnaire study and in an…

  3. A Corpus-based Approach to English Subordinate Clause I dentification

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The complex sentence structure of English is a bottleneck to our practical machi ne translation system. The simplification of English subordinate clauses will gr eatly relieves the burden of parsing and other grammatical or semantic analysis of a complex sentence, thus improves the output quality of the MT system. But th ere have not any satisfactory research achievements reported in this field up t o now as we know. In this paper, author's work on a corpus-based approach to English subordinate clause identification is reported. The approach integrate s rule-base d and statistical methods to get the left and right boundaries of the subordinat e clauses. The Penn Treebank corpus is used as the training standard. The precis ion and recall ratios of subordinate clause identification are tested on both cl osed and open corpora. A result of 92.9% precision and 91.26% recall is obtained for the closed test and the open test result is 80.34% precision and 83.93% rec all. This algorithm has been integrated into our machine translation system. The method can also be applied to processing of any other language.

  4. A Shock to the Conscience: The Due Process Clause and Corporal Punishment.

    Science.gov (United States)

    Dowling-Sendor, Benjamin

    2001-01-01

    In a case involving an injured football player, an 11th Circuit judge viewed a coach's refusal to stop a fight as corporal punishment. Federal courts in five circuits have ruled that excessive corporal punishment violates the Due Process Clause if it is so brutal and harmful that it shocks the court's conscience. (MLH)

  5. The Role of Working Memory and Contextual Constraints in Children's Processing of Relative Clauses

    Science.gov (United States)

    Wieghall, Anna R.; Altmann, Gerry T. M.

    2011-01-01

    An auditory sentence comprehension task investigated the extent to which the integration of contextual and structural cues was mediated by verbal memory span with 32 English-speaking six- to eight-year-old children. Spoken relative clause sentences were accompanied by visual context pictures which fully (depicting the actions described within the…

  6. 78 FR 73475 - Defense Federal Acquisition Regulation Supplement: Clauses With Alternates-Research and...

    Science.gov (United States)

    2013-12-06

    ... include your name, company name (if any), and ``DFARS Case 2013-D026'' on your attached document. Email... INFORMATION: I. Background In order to facilitate use of automated contract writing systems, DoD is processing... proposes to make the following changes: Amend section 235.072, Additional Contract Clauses, to reflect...

  7. Force majeure clauses and the threat of nuclear disaster. A Japanese case study

    International Nuclear Information System (INIS)

    Force majeure clauses can be found in any commercial contract. Though more or less clear guidelines for the applicability of force majeure (clauses) exist in the form of international and national law, the applicability and enforceability of force majeure clauses with respect to nuclear incidents or disasters, however, remain ambiguous. Until the Japanese nuclear disaster, no major trade region was affected by any of the historical nuclear incidents. This case-study is based on the events surrounding the Tohoku earthquake, respective tsunami and nuclear incidents, especially at the Daiichi NPP and radiological contamination released there. The applicability and enforceability of force majeure clauses with their wide legal and economical implications are analyzed and evaluated according to the CISG and national domestic Japanese law. It is found that the assertion of force majeure is generally highly fact-specific and circumstance-sensitive. In general, the potential of nuclear disaster as an event triggering the force majeure defence is clearly evident, according to both international and Japanese law. Any claim must, however, be substantiated according to the principles of the different legal regimes under which the contract falls. In consequence, a company located within the evacuated areas will probably be able to successfully assert for majeure, whilst the success of any other claim will depend on the presentation of evidence, such as radiation levels and its effects in hindering performance of contractual obligations.

  8. 48 CFR 225.7006-4 - Solicitation provision and contract clause.

    Science.gov (United States)

    2010-10-01

    ... and contract clause. (a) Use the provision at 252.225-7037, Evaluation of Offers for Air Circuit Breakers, in solicitations requiring air circuit breakers for naval vessels unless— (1) An exception... Breakers, in solicitations and contracts requiring air circuit breakers for naval vessels unless— (1)...

  9. 48 CFR 970.2703-2 - Patent rights clause provisions for management and operating contractors.

    Science.gov (United States)

    2010-10-01

    ... dedicated to naval nuclear propulsion or weapons related programs. That clause provides for DOE's statutory...-exempted areas of technology or in operation of DOE facilities primarily dedicated to naval nuclear propulsion or weapons related programs. (b) Allocation of Principal Rights: Government title. (1) The...

  10. The Meaning of Mood – Embedded Clauses in Spanish as a Case in Point

    DEFF Research Database (Denmark)

    Jensen, Helle Dam

    2011-01-01

    result of an interpretive process. This article explains how mental space theory can be used in an analysis of mood in embedded clauses in Spanish. It starts from the assumption that the meaning of mood is constructed by interlocutors in an interpretive process on the basis of information from the modal...

  11. The acoustic characteristics of clause, sentence and paragraph boundaries in Chinese Putonghua

    Institute of Scientific and Technical Information of China (English)

    WANG Bei; YANG Yufang; L(U) Shinan

    2006-01-01

    The acoustic and perceptive characteristics of discourse units, including clauses,simple sentences, compound sentences and paragraphs, were studied. The acoustic characteristics were based on the analysis of a speech corpus consisted of ten monologues. The Perceived Boundary Strength (PBS) of the monologues was labeled on a five-point scale by 25 participants. The main results are as follows: (1) There is a significant difference in the PBS of clauses (corresponding to intonational phrase), sentences (including simple sentences and compound sentences) and paragraphs. But the PBS of simple sentences and compound sentences is the same, and the pitch reset and pause are also not significantly different between these two kinds of boundaries. (2) The pitch-based cue used to distinguish clauses, sentences and paragraphs appears to be the difference between pre- and post-boundary syllables, but not simply the pitch value of either syllable alone. (3) Declination mainly occurs within intonational phrases,whereas there is no consistent global declination in sentences or in paragraphs. (4) Pauses are longer and more varied at the boundary of larger discourse units. Moreover, there is a significant positive correlation between pause duration and degree of pitch reset at clause boundaries,but not at sentence or paragraph boundaries.

  12. Lichomolgus longicauda (Claus, 1860), Copepod parasite of Sepia, in the North Sea

    NARCIS (Netherlands)

    Stock, J.H.

    1956-01-01

    Lichomolgus longicauda (CLAUS, 1860), is recorded from the gills of Sepia officinalis, captured on 5 different occasions in the North Sea and the Dutch Waddensea. This means a northward extension of the range of this species of more than 8 degrees of latitude. Figures of the parasite have been provi

  13. 48 CFR 742.1170-4 - Progress reporting requirements and contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Progress reporting requirements and contract clause. 742.1170-4 Section 742.1170-4 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Production, Surveillance, and Reporting 742.1170-4 Progress...

  14. 48 CFR 227.7009-3 - Additional clauses-contracts except running royalty contracts.

    Science.gov (United States)

    2010-10-01

    ...-contracts except running royalty contracts. 227.7009-3 Section 227.7009-3 Federal Acquisition Regulations...—contracts except running royalty contracts. The following clauses are examples for use in patent release and settlement agreements, and license agreements not providing for payment by the Government of a...

  15. Introduction to the CoNLL-2001 Shared Task: Clause Identification

    OpenAIRE

    Sang, Erik F. Tjong Kim; Dejean, Herve

    2001-01-01

    We describe the CoNLL-2001 shared task: dividing text into clauses. We give background information on the data sets, present a general overview of the systems that have taken part in the shared task and briefly discuss their performance.

  16. Force majeure clauses and the threat of nuclear disaster. A Japanese case study

    Energy Technology Data Exchange (ETDEWEB)

    Guderian, Stephan Michael

    2011-07-22

    Force majeure clauses can be found in any commercial contract. Though more or less clear guidelines for the applicability of force majeure (clauses) exist in the form of international and national law, the applicability and enforceability of force majeure clauses with respect to nuclear incidents or disasters, however, remain ambiguous. Until the Japanese nuclear disaster, no major trade region was affected by any of the historical nuclear incidents. This case-study is based on the events surrounding the Tohoku earthquake, respective tsunami and nuclear incidents, especially at the Daiichi NPP and radiological contamination released there. The applicability and enforceability of force majeure clauses with their wide legal and economical implications are analyzed and evaluated according to the CISG and national domestic Japanese law. It is found that the assertion of force majeure is generally highly fact-specific and circumstance-sensitive. In general, the potential of nuclear disaster as an event triggering the force majeure defence is clearly evident, according to both international and Japanese law. Any claim must, however, be substantiated according to the principles of the different legal regimes under which the contract falls. In consequence, a company located within the evacuated areas will probably be able to successfully assert for majeure, whilst the success of any other claim will depend on the presentation of evidence, such as radiation levels and its effects in hindering performance of contractual obligations.

  17. Material Adverse Effect Clause – Proper Legal Work or Contribution to False Sense of Security?

    DEFF Research Database (Denmark)

    Fomcenco, Alex

    2014-01-01

    Regardless of whether you are a buyer or a seller, and regardless what the object of the contract is, it is essentially important that you seek to protect your rights through various clauses that must aim to provide clearness to contractual obligations, defini- tions of breach, and consequences t...

  18. Interpreting conjoined noun phrases and conjoined clauses: collective versus distributive preferences.

    Science.gov (United States)

    Clifton, Charles; Frazier, Lyn

    2012-01-01

    Two experiments are reported that show that introducing event participants in a conjoined noun phrase (NP) favours a single event (collective) interpretation, while introducing them in separate clauses favours a separate events (distributive) interpretation. In Experiment 1, acceptability judgements were speeded when the bias of a predicate toward separate events versus a single event matched the presumed bias of how the subjects' referents were introduced (as conjoined noun phrases or in conjoined clauses). In Experiment 2, reading of a phrase containing an anaphor following conjoined noun phrases was facilitated when the anaphor was they, relative to when it was neither/each of them; the opposite pattern was found when the anaphor followed conjoined clauses. We argue that comprehension was facilitated when the form of an anaphor was appropriate for how its antecedents were introduced. These results address the very general problem of how we individuate entities and events when presented with a complex situation and show that different linguistic forms can guide how we construe a situation. The results also indicate that there is no general penalty for introducing the entities or events separately-in distinct clauses as "split" antecedents. PMID:22512324

  19. An Inplementation of Pure Horn Clause Logic Programming in a Reduction System

    Institute of Scientific and Technical Information of China (English)

    许满武

    1993-01-01

    Many reduction systems have been presented for implementing functional programming languages.We propose here an extension of a reduction architecture to realize a kind of logic programming-pure Horn clause logic programming.This is an attempt to approach amalgamation of the two important programming paradigms.

  20. 48 CFR 970.2703-1 - Purposes of patent rights clauses.

    Science.gov (United States)

    2010-10-01

    ... not have advance class waiver under 10 CFR part 784, the patent rights clause at 970.5227-11 is... 10 CFR part 784. Under such contracts, the M&O contractor assumes responsibilities for... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Purposes of patent...

  1. MD5和DES算法在市政网络平台中的应用%Municipal network platform based on md5 funtion and DES algrithm

    Institute of Scientific and Technical Information of China (English)

    邓中亮; 曹其可; 葛悦涛

    2011-01-01

    鉴于市政管理数据中包含大量敏感信息,为解决目前移动终端访问市政平台所存在的安全问题,采用MD5和DES算法,设计一移动通信中间件,对现有的网络进行改进以实现平台的安全机制.MD5算法用采实现身份认证过程,DES算法结合非对称加密和数字签名技术来保证信息的安全传输.该中间件可以以动态库的形式集成在客户端设备与市政管委的Web服务器上,因此可以不需要对现有资源进行较大的改动,以较小的代价达到安全性目标,大大降低部署的难度.%As the database of municipal administration contains large amounts of sensitive information, we designed this mobile middleware to optimized the exsiting platform and protected the sensitive data be attacted. This middleware is based on MD5 and DES algorithm. MD5 algorithm is used to implement the authentication process. DES algorithm combined with asymmetric encryption and digital signature to ensure the safety of information transmission. The middleware can be integrated in the client device and the Web server of the municipal in the form of dynamic libraries. You can achieve the security goals without need to carry out major changes to the existing resources, greatly reduced the difficulty of deployment.

  2. 基于CUDA架构的MD5并行分析算法研究%Research of MD5 Parallel Algorithm Based on CUDA

    Institute of Scientific and Technical Information of China (English)

    张伟; 陈田国; 陶志荣

    2009-01-01

    在介绍了CUDA(统一计算设备架构)架构的基础上,给出了一种CUDA架构上进行MD5摘要分析的并行算法.算法有效利用了GPU的并行性和CUDA架构的优势实现了较快的运算速度,测试结果显示优于CPU的算法.

  3. MD5算法与Web口令的安全传输%MD5 Algorithm and Security Transfer of Web Password

    Institute of Scientific and Technical Information of China (English)

    丁振国; 刘斌

    2004-01-01

    在研究了现存的采用单向散列算法对口令加密传输机制的缺点的基础上,提出了一种用MD5算法加密口令的改进方案,不仅实现简单,而且有效地提高了Web认证系统中口令传输的安全性.

  4. 基于MD5与Base64的混合加密算法%MD5-Base64 based hybrid encryption algorithm

    Institute of Scientific and Technical Information of China (English)

    罗江华

    2012-01-01

    介绍了一种基于MD5和Base64的混合加密算法,首先将明文MD5加密得到32位16进制密文,再将32位密文拆分成16个2位16进制数组,并转换成对应的二进制数,最后将16个二进制数组连接成一个128位的2进制数,采用Base64加密原理进行加密.该算法可以避免查询MD5散列值字典获取用户明文密码,更加有效地保证了用户的密码安全,最后给出了算法的PHP实现.%A MD5-Base64 baaed hybrid encryption algorithm was introduced, which encrypted plain text to 32-bit hexadecimal cipher text by MDS encryption, then split this 32-bit hexadecimal into 16 parts, and transformed them into binary Cor each part to join them together as a 128-bit binary, finally, encrypted the 128-bit binary array by using Base64 algorithm. This algorithm can avoid getting user's clear text password by querying MDS hash database, and protect user's password more effectively. This algorithm was described by PHP script language at the fourth section.

  5. 基于FPGA的MD5算法设计与实现%Design and Implementation of MD5 Algorithm Based on FPGA

    Institute of Scientific and Technical Information of China (English)

    王波涛; 韩国栋; 张效军

    2010-01-01

    MD5算法在网络安全的诸多方面都得到广泛的应用,在一些特殊场合要求计算具有高处理速度,低资源占用率的特点.文中首先介绍了MD5算法的发展历程和算法原理,然后描述了该算法在FPGA上实现的整体架构,分析了其各模块的功能,最后给出了基于Altera公司的Stratix Ⅱ GX系列FPGA的实现结果.通过实验结果可以看出基于FPGA的MD5算法实现具有较高的处理速度和较少的资源占用,并可对设计进行适当修改来实现其它的摘要算法,具有一定的实用价值.

  6. Effectiveness of price adjustment clauses in district heat supply contracts. Consequences of the 2011 BGH rulings; Wirksamkeit von Preisanpassungsklauseln in Fernwaermelieferungsvertraegen. Konsequenzen der BGH-Urteile 2011

    Energy Technology Data Exchange (ETDEWEB)

    Buedenbender, Ulrich; Gromm, Marcel [TU Dresden (Germany). Lehrstuhl fuer Buergerliches Recht, Energiewirtschaftsrecht und Arbeitsrecht

    2011-07-01

    In 2011, the BGH had to decide for the first time on price adjustment clauses. There were four court rulings on price adjustment clauses in district heat supply contracts, and price adjustment clauses were considered to be ineffective in all cases. This is a trend similar to the rulings on gas supply contracts since 2005. This contribution discusses the consequences of the 2011 BGH rulings for future price adjustment clauses in district heat supply contracts. The contract partners, especially the customers of district heating utilities, must be sure whether a raised supply price will be based on an effective price adjustment clause, or whether it will enable the customer to refuse payment. (orig.)

  7. Web开发中MD5摘要计算的应用——Struts技术实现

    Institute of Scientific and Technical Information of China (English)

    鲁屹华

    2008-01-01

    M05的全称是Message-Digest Algorithm 5(信息-摘要算法),在90年代初由MIT Laboratory for Computer Science和RSA Data Security Inc的Ronald L.Rivest开发出来,经MD2、MD3和MD4发展而来.本文首先介绍了MD5算法的概念.然后阐述了Java语言的java.security包对MD5算法的支持,并基于Sun公司Java 2平台企业版(J2EE)MVC框架Struts技术,针对B/S模式毕业设计选题系统中的学生基本信息注册模块所采用的MD5摘要计算作了详细介绍.

  8. Comparison of time adjustment clauses between DZ3910, AS4000 and STCC

    Directory of Open Access Journals (Sweden)

    David Finnie

    2013-03-01

    Full Text Available This article examines time adjustment clauses, as they relate to time adjustment between standard terms of construction contracts. DZ3910, AS4000 and STCC were compared on the basis of how risks are allocated, how this may impact on the contractor’s pricing, and ease of understanding for each clause. ASTCC was found to be the most easily interpreted contract, followed by AS4000 and then NZS3910. These assessments were based on the following: a whether each contract contains words with multiple meanings, b the number of words used per sentence, c the amount of internal cross-referencing, and d the clarity of the contract structure. The allowable pre-conditions for the contractor to claim a time adjustment are similar for all three contracts, and none of them expressly state which party is to bare the risk of buildability, or address the risk of a designer’s disclaimer clause. All of the contracts adopt the principle of contra preferentum which means that the employer bares the risk of variance if there are any ambiguities in the design documentation. Due to their similarities of risk allocation, all of the contracts provide the employer with a similar amount of price surety. AS4000 is the only contract to contain a stringent time-bar clause, limiting a contractor’s time adjustment claim. ASTCC requires the contractor to apply ‘immediately’ and DZ3910 provides a time-bar of 20 working days or as soon as practicable. None of the contracts clarify whether their timing requirements take precedence over the prevention principle, or over any other ground for claiming a time adjustment. The effect of DZ3910’s pre-notification clause 5.19.3 is discussed, and an alternative contents structure is recommended for DZ3910, using a project management method. 

  9. Comparison of time adjustment clauses between DZ3910, AS4000 and STCC

    Directory of Open Access Journals (Sweden)

    David Finnie

    2013-03-01

    Full Text Available This article examines time adjustment clauses, as they relate to time adjustment between standard terms of construction contracts. DZ3910, AS4000 and STCC were compared on the basis of how risks are allocated, how this may impact on the contractor’s pricing, and ease of understanding for each clause. ASTCC was found to be the most easily interpreted contract, followed by AS4000 and then NZS3910. These assessments were based on the following: a whether each contract contains words with multiple meanings, b the number of words used per sentence, c the amount of internal cross-referencing, and d the clarity of the contract structure. The allowable pre-conditions for the contractor to claim a time adjustment are similar for all three contracts, and none of them expressly state which party is to bare the risk of buildability, or address the risk of a designer’s disclaimer clause. All of the contracts adopt the principle of contra preferentum which means that the employer bares the risk of variance if there are any ambiguities in the design documentation. Due to their similarities of risk allocation, all of the contracts provide the employer with a similar amount of price surety. AS4000 is the only contract to contain a stringent time-bar clause, limiting a contractor’s time adjustment claim. ASTCC requires the contractor to apply ‘immediately’ and DZ3910 provides a time-bar of 20 working days or as soon as practicable. None of the contracts clarify whether their timing requirements take precedence over the prevention principle, or over any other ground for claiming a time adjustment. The effect of DZ3910’s pre-notification clause 5.19.3 is discussed, and an alternative contents structure is recommended for DZ3910, using a project management method.

  10. The topology of foliations formed by the generic K-orbits of a subclass of the indecomposable MD5-groups

    Institute of Scientific and Technical Information of China (English)

    VU Le Anh; HOA Duong Quang

    2009-01-01

    The paper is a continuation of the authors' works in 2007. We consider the MD5-foliations associated to connected and simply connected MD5-groups such that their Lie algebras have 4-dimensional commutative derived ideals. In this study, we give a topological classification of all considered MD5-foliations. A description of these foliations by certain fibrations or suitable actions of R2 and the Connes' C*-algebras of the foliations which come from fibrations are also given.

  11. LHC Transvers Profile Monitors studies (MD on May 6th, 2011)

    CERN Document Server

    Bravin, E; Dehning, B; Emery, J; Lefevre, T; Gras, JJ; Jeff, A; Rabiller, A; Roncarolo, F; Sapinski, M; Kain, V; Pojer, M; Bartosik, H; Salvant, B

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 6-May-2011 (from 2 to 10 a.m.), dedicated to study Wire Scanners (WS), Synchrotron Radiation Monitors (BSRT) and Beam Gas Ionization Monitors (BGI). The MD aimed at performing different studies on the individual monitors as well as at cross calibrating them with beams composed of bunches with different transverse emittances in stable conditions. At the same time, it was possible to perform calibration studies with the Abort Gap Monitor (AGM) and Longitudinal Density Monitor (LDM) that share the extracted light with the BSRT.

  12. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools

    OpenAIRE

    Amy Franciscovich; Dhananjay Vaidya; Joe Doyle; Josh Bolinger; Montserrat Capdevila; Marcus Rice; Leslie Hancock; Tanya Mahr; Mogul, Douglas B.

    2015-01-01

    Biliary atresia (BA) is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 an...

  13. Usefulness of multidetector-row CT (MD-CT) for assessment of coronary artery stenosis

    International Nuclear Information System (INIS)

    Coronary arteries stenosis were evaluated in 49 cases by volume rendering (VR) and partial maximum intensity projection (partial MIP) using multidetector-row CT (MD-CT). Left main trunk (LMT) and left anterior descending artery (LAD) were less affected by cardiac pulsation artifact and presented good images. Right coronary artery (RCA) was affected by cardiac pulsation artifact and image quality was inferior as compared to left coronary artery (LCA). It is suggested that MD-CT is useful for assessment of coronary artery stenosis, especially LCA. (author)

  14. Computation of shear viscosity of colloidal suspensions by SRD-MD

    Energy Technology Data Exchange (ETDEWEB)

    Laganapan, A. M. K.; Videcoq, A., E-mail: arnaud.videcoq@unilim.fr; Bienia, M. [SPCTS, UMR 7315, ENSCI, CNRS, Centre Européen de la Céramique, 12 rue Atlantis, 87068 Limoges Cedex (France); Ala-Nissila, T. [COMP CoE at the Department of Applied Physics, Aalto University School of Science, P.O. Box 11000, FIN-00076 Aalto, Espoo (Finland); Department of Physics, Brown University, Providence, Rhode Island 02912-1843 (United States); Bochicchio, D.; Ferrando, R. [Dipartimento di Fisica and CNR-IMEM, via Dodecaneso 33, Genova I-16146 (Italy)

    2015-04-14

    The behaviour of sheared colloidal suspensions with full hydrodynamic interactions (HIs) is numerically studied. To this end, we use the hybrid stochastic rotation dynamics-molecular dynamics (SRD-MD) method. The shear viscosity of colloidal suspensions is computed for different volume fractions, both for dilute and concentrated cases. We verify that HIs help in the collisions and the streaming of colloidal particles, thereby increasing the overall shear viscosity of the suspension. Our results show a good agreement with known experimental, theoretical, and numerical studies. This work demonstrates the ability of SRD-MD to successfully simulate transport coefficients that require correct modelling of HIs.

  15. 78 FR 32556 - Safety Zone; 2013 Ocean City Air Show, Atlantic Ocean; Ocean City, MD

    Science.gov (United States)

    2013-05-31

    ... FR Federal Register NPRM Notice of Proposed Rulemaking A. Regulatory History and Information The... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; 2013 Ocean City Air Show, Atlantic Ocean; Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard...

  16. 76 FR 60873 - Jeffery M. Freesemann, M.D.; Decision and Order

    Science.gov (United States)

    2011-09-30

    ... changes in her ] that he found more ``attractive,'' such as how she was more prone to stay up late and... will not engage in future misconduct. Cf. Ronald Lynch, M.D., 75 FR 78745, 78749 (2010). Order Pursuant.... 52. Galvan told her that around noon he would pick up ``paperwork'' (a term that Det. Boyd...

  17. 75 FR 26993 - Alvin Darby, M.D.; Denial of Application

    Science.gov (United States)

    2010-05-13

    ... dependency on crack cocaine and `primo,' a mixture of cocaine and marijuana smoked together.'' GX 3, at 2... factors are * * * considered in the disjunctive.'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003). I... application under section 303. See The Lawsons, Inc., 72 FR 74334, 74337 (2007); Anthony D. Funches, 64...

  18. 76 FR 31235 - Safety Zone; Ocean City Air Show, Atlantic Ocean, Ocean City, MD

    Science.gov (United States)

    2011-05-31

    ... Ocean City, Maryland. (b) Definition: For purposes of enforcement of this section, Captain of the Port... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Ocean City Air Show, Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Temporary Final rule. SUMMARY: The Coast Guard...

  19. Functional identification of MdSIZ1 as a SUMO E3 ligase in apple.

    Science.gov (United States)

    Zhang, Rui-Fen; Guo, Ying; Li, Yuan-Yuan; Zhou, Li-Jie; Hao, Yu-Jin; You, Chun-Xiang

    2016-07-01

    SUMOylation, the conjugation of target proteins with SUMO (small ubiquitin-related modifier), is a type of post-translational modification in eukaryotes and involves the sequential action of activation (E1), conjugation (E2) and ligation (E3) enzymes. In Arabidopsis, the AtSIZ1 protein is a SUMO E3 ligase that promotes the conjugation of SUMO proteins to target substrates. Here, we isolated and identified a SUMO E3 ligase, MdSIZ1, in apple, which was similar to AtSIZ1. SUMOylation analysis showed that MdSIZ1 had SUMO E3 ligase activity in vitro and in vivo. SUMO conjugation was increased by high temperatures, low temperatures, and abscisic acid (ABA). The ectopic expression of MdSIZ1 in Arabidopsis siz1-2 mutant plants partially complemented the morphological mutant phenotype and enhanced the levels of SUMO conjugation. Taken together, these results suggest that MdSIZ1-mediated SUMO conjugation of target proteins is an important process that regulates the adaptation of apple plants to various environmental stresses. PMID:27152458

  20. 77 FR 3185 - Proposed Establishment of Class E Airspace; Grasonville, MD

    Science.gov (United States)

    2012-01-23

    ... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of..., 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The incorporation by... Grasonville, MD, providing the controlled airspace required to support the Copter RNAV GPS special...

  1. 77 FR 22523 - Safety Zone; 2012 Ocean City Air Show; Atlantic Ocean, Ocean City, MD

    Science.gov (United States)

    2012-04-16

    ... Federal Register (73 FR 3316). ] Public Meeting We do not now plan to hold a public meeting. But you may... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; 2012 Ocean City Air Show; Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast...

  2. 78 FR 76322 - Thomas Neuschatz, M.D.; Decision and Order

    Science.gov (United States)

    2013-12-17

    ... of J.G.'s known addiction, ``but inaccurately represented this as a treatment for a chronic pain... her chronic pain rather than as treatment for her opioid addiction was patently false.'' Id. at 18...(f). ``These factors are . . . considered in the disjunctive.'' Robert A. Leslie, M.D., 68 FR...

  3. 77 FR 45675 - Margy Temponeras, M.D.; Decision and Order

    Science.gov (United States)

    2012-08-01

    ... that Mrs. Leadingham similarly stated that ``she was there to dispense the medication and put the... medication to patients.'' (Id.) The location was described as having the doctor's office on the left of the... encompasses the factors listed in Section 824(a).'' ALJ at 19 n.24 (citing Kuen H. Chen, M.D., 58 FR...

  4. Novel plasmid conferring kanamycin and tetracycline resistance in turkey-derived Campylobacter jejuni strain 11601MD

    Science.gov (United States)

    In Campylobacter spp., resistance to the antibiotics kanamycin and tetracycline is frequently associated with plasmid-borne genes. However, relatively few plasmids of Campylobacter jejuni have been fully characterized to date. A novel plasmid (p11601MD; 44,095 bp.) harboring tet(O) was identified in...

  5. 76 FR 65118 - Drawbridge Operation Regulation; Bear Creek, Sparrows Point, MD

    Science.gov (United States)

    2011-10-20

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Bear Creek, Sparrows... Avenue) highway toll drawbridge across Bear Creek, mile 1.5, Sparrows Point, MD was replaced with a fixed... Bear Creek, mile 1.5 was removed and replaced with a fixed bridge in 1998. Prior to 1998, a...

  6. 77 FR 23599 - Special Local Regulations for Marine Events; Potomac River, Charles County, MD

    Science.gov (United States)

    2012-04-20

    ... regulations to the Small Business and Agriculture Regulatory Enforcement Ombudsman and the Regional Small...; Potomac River, Charles County, MD'' in the Federal Register (77 FR 27). We received one comment on the... substantial number of small entities. The term ``small entities'' comprises small businesses,...

  7. Draft Genome Sequence of Lactobacillus jensenii Strain MD IIE-70(2)

    OpenAIRE

    Karlyshev, Andrey V.; Nadarajah, Sindhujan; Abramov, Vyacheslav M.

    2013-01-01

    A draft genome sequence of Lactobacillus jensenii strain MD IIE-70(2) was determined using Ion PGM technology. The reads were mapped to a reference strain and assembled using a combination of tools. The genetic features revealed in this study will assist in understanding the probiotic properties of Lactobacillus bacteria.

  8. Draft Genome Sequence of Lactobacillus jensenii Strain MD IIE-70(2).

    OpenAIRE

    Karlyshev, Andrey V.; Nadarajah, Sindhujan; Abramov, Vyacheslav M.

    2013-01-01

    A draft genome sequence of Lactobacillus jensenii strain MD IIE-70(2) was determined using Ion PGM technology. The reads were mapped to a reference strain and assembled using a combination of tools. The genetic features revealed in this study will assist in understanding the probiotic properties of Lactobacillus bacteria.

  9. 78 FR 76169 - Patuxent Research Refuge, Prince George's and Anne Arundel Counties, MD; Final Comprehensive...

    Science.gov (United States)

    2013-12-16

    .... Geological Survey (USGS) Patuxent Wildlife Research Center, a leading international research institute for... Fish and Wildlife Service Patuxent Research Refuge, Prince George's and Anne Arundel Counties, MD... significant impact (FONSI) for Patuxent Research Refuge (Patuxent RR, refuge), located in Prince George's...

  10. 75 FR 18778 - Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD

    Science.gov (United States)

    2010-04-13

    ... public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316). Public Meeting We do... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast...

  11. Heat Flow Data Cruise MD72 RV Marion Dufresne over the Mascarene Ridge

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Data were gathered by the R/V Marion Dufresne in May and June of 1992 over the Mascarene Ridge in the Indian Ocean on cruise MD72/MASCAFLUX. Heat flow measurements...

  12. Electrochemical endotoxin sensors based on TLR4/MD-2 complexes immobilized on gold electrodes.

    Science.gov (United States)

    Yeo, Tae Yun; Choi, Ji Suk; Lee, Byung Kook; Kim, Beob Soo; Yoon, Hwa In; Lee, Hyeong Yun; Cho, Yong Woo

    2011-10-15

    Even low concentrations of endotoxins can be life-threatening. As such, continuous effort has been directed toward the development of sensitive and specific endotoxin detection systems. In this paper, we report the design and fabrication of a new electrochemical endotoxin sensor based on a human recombinant toll-like receptor 4 (rhTLR4) and myeloid differentiation-2 (MD-2) complex. The rhTLR4/MD-2 complex, which specifically binds to endotoxin, was immobilized on gold electrodes through a self-assembled monolayer (SAM) technique involving the use of dithiobis(succinimidyl undecanoate) (DSU). The surface topography of the electrodes at each fabrication stage was characterized with a nanosurface profiler and atomic force microscope (AFM). The electrochemical signals generated from interactions between the rhTLR4/MD-2 complex and the endotoxin were characterized by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). A linear relationship between the peak current and endotoxin concentration was obtained in the range of 0.0005 to 5 EU/mL with a correlation coefficient (R(2)) of 0.978. The estimated limit of detection (LOD) was fairly low, 0.0002 EU/mL. The rhTLR4/MD-2 based sensors exhibited no current responses to dipalmitoylphosphatidylcholine (DPPC) bearing two lipid chains, which is structurally similar to endotoxin, indicating the high specificity of the sensors to endotoxin. PMID:21816600

  13. 75 FR 41789 - Special Local Regulations for Marine Events; Patuxent River, Solomons, MD

    Science.gov (United States)

    2010-07-19

    ... public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316). Public Meeting We do... for Marine Events; Patuxent River, Solomons, MD'' in the Federal Register (75 FR 111). The NPRM stated... Solomon's Pier. A large spectator fleet is expected during the event. Due to the need for vessel...

  14. INHERENT VICE & INSUFFICIENT PACKING CLAUSES FOR ALL RISKS INSURANCE POLICIES UNDER BRITISH INSTITUTE CARGO CLAUSES : legal issues arising from claims of loss during sea transportation of large technical equipments

    OpenAIRE

    2010-01-01

    Analysis and presentation of this thesis is supported by studies of many relevant cases where the major arguments are set around the exclusion clauses concerning the ‘all risks cover’ policy as found in Institute Cargo Clauses. Two cases are especially emphasized, namely Mayban General Assurance BHD v. Alstom Power Plants Ltd. and Global Process Systems Inc v. Syarikat Takaful Malaysia Berhad , mainly because of the special nature of the subject matter insured in these cases. The legal i...

  15. Identification of key residues that confer Rhodobacter sphaeroides LPS activity at horse TLR4/MD-2.

    Directory of Open Access Journals (Sweden)

    Katherine L Irvine

    Full Text Available The molecular determinants underpinning how hexaacylated lipid A and tetraacylated precursor lipid IVa activate Toll-like receptor 4 (TLR4 are well understood, but how activation is induced by other lipid A species is less clear. Species specificity studies have clarified how TLR4/MD-2 recognises different lipid A structures, for example tetraacylated lipid IVa requires direct electrostatic interactions for agonism. In this study, we examine how pentaacylated lipopolysaccharide from Rhodobacter sphaeroides (RSLPS antagonises human TLR4/MD-2 and activates the horse receptor complex using a computational approach and cross-species mutagenesis. At a functional level, we show that RSLPS is a partial agonist at horse TLR4/MD-2 with greater efficacy than lipid IVa. These data suggest the importance of the additional acyl chain in RSLPS signalling. Based on docking analysis, we propose a model for positioning of the RSLPS lipid A moiety (RSLA within the MD-2 cavity at the TLR4 dimer interface, which allows activity at the horse receptor complex. As for lipid IVa, RSLPS agonism requires species-specific contacts with MD-2 and TLR4, but the R2 chain of RSLA protrudes from the MD-2 pocket to contact the TLR4 dimer in the vicinity of proline 442. Our model explains why RSLPS is only partially dependent on horse TLR4 residue R385, unlike lipid IVa. Mutagenesis of proline 442 into a serine residue, as found in human TLR4, uncovers the importance of this site in RSLPS signalling; horse TLR4 R385G/P442S double mutation completely abolishes RSLPS activity without its counterpart, human TLR4 G384R/S441P, being able to restore it. Our data highlight the importance of subtle changes in ligand positioning, and suggest that TLR4 and MD-2 residues that may not participate directly in ligand binding can determine the signalling outcome of a given ligand. This indicates a cooperative binding mechanism within the receptor complex, which is becoming increasingly

  16. 48 CFR 1428.311 - Solicitation provision and contract clause on liability insurance under cost-reimbursement...

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Solicitation provision and contract clause on liability insurance under cost-reimbursement contracts. 1428.311 Section 1428.311... under cost-reimbursement contracts....

  17. 基于C#技术的MD5加密算法设计与实现%Design and Implementation of MD5 Algorithm Based on C# Technology

    Institute of Scientific and Technical Information of China (English)

    王倩丽

    2010-01-01

    本文对Message-Digest Algorithm 5(信息-摘要算法)进行了简要描述,并对MD5算法的原理进行了深入分析.同时采用目前流行的C#语言对MD5算法进行了具体的应用,实现了MD5加密演示系统.虽然MD5算法因王小云教授在2004国际密码学会议上发表的论文引起了很大的反响,但MD5算法仍然在数字签名、电子商务、信息加密等领域中有着非常广泛的应用.

  18. MD5 Encryption Algorithm and its Application in NETPRO Protocol%MD5加密算法及其在NETPRO协议中的应用

    Institute of Scientific and Technical Information of China (English)

    王大志; 马良

    2005-01-01

    短信网关系统中,内容提供商与网关之间通信采用客户机/服务器(C/S)模式,网关通过NETPRO协议与内容提供商通信.网络安全问题变得非常突出,对于用户密码等敏感信息,应该有一种能有效防止被轻易截获的方法来保护.MD5加密算法就是这种设想的强有力的工具.

  19. International Validation of the CLAU-S Quality-of-Life Questionnaire for Use in Patients with Intermittent Claudication

    OpenAIRE

    Patrick Marquis; Sylvie Comte; Philippe Lehert

    2001-01-01

    Background: Intermittent claudication (IC) occurs in patients with peripheral occlusive arterial disease and results in leg pain after walking a certain distance - the claudication distance. Until recently, no specific questionnaire has been available to measure quality of life in patients with IC. Objectives: To validate the Claudication Scale (CLAU-S) questionnaire in patients in France, the UK, Germany and Belgium. Methods: Patients completed the CLAU-S questionnaire and provided demograph...

  20. Exclusionary practices in two-sided markets: The effect of radius clauses on competition between shopping centers

    OpenAIRE

    Brühn, Tim; Götz, Georg

    2015-01-01

    This paper analyzes exclusionary conduct of platforms in two-sided markets. Motivated by recent antitrust cases against shopping centers introducing radius restrictions on their tenants, we provide a discussion of the likely positive and normative effects of exclusivity clauses, which prevent tenants from opening outlets in other shopping centers covered by the clause. In a standard two-sided market model with two competing shopping centers, we analyze incentives to introduce exclusivity clau...