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Sample records for claus manniche md

  1. Polycyclic alkaloids via transannular Mannich reactions

    DEFF Research Database (Denmark)

    Vital, Paulo; Hosseini, Masood; Shanmugham, M. S.;

    2009-01-01

    The tricyclic compound 13, representing the framework of the cylindricine 4 and lepadiformine 5 alkaloids, was prepared in a single operation via the first example of a transannular Mannich reaction involving a macrocyclic diketoamine 12.......The tricyclic compound 13, representing the framework of the cylindricine 4 and lepadiformine 5 alkaloids, was prepared in a single operation via the first example of a transannular Mannich reaction involving a macrocyclic diketoamine 12....

  2. Mannich reaction: A versatile and convenient approach to bioactive skeletons

    Indian Academy of Sciences (India)

    Selva Ganesan Subramaniapillai

    2013-05-01

    This review gives an insight into the recent applications of Mannich reaction and its variants in the construction of bioactive molecules. Emphasis is given to the Mannich reaction that provides bioactive molecules and/or modifies the property of an existing bioactive molecule. The role of Mannich reaction in the construction of antimalarial, antitumour, antimicrobial, antitubercular, antiinflammatory and anticonvulsant molecules and also the significance of aminoalkyl Mannich side chain on the biological property of molecules is discussed here.

  3. Biosynthesis of some Mannich bases

    Directory of Open Access Journals (Sweden)

    Bruna S. D. R. Aranha

    2012-06-01

    Full Text Available The Mannich reaction is extremely useful to form molecules that contain nitrogen groups. Currently, there is a great interest turned to this class of compounds due to its biological properties. The recent literature reports that the utilization of enzymes can be an adequate methodology on this type of reaction. According to the exposed above and with the intention of synthesizing the -aminoketones, some catalysts like Chymosin and also some microorganisms such as Saccharomyces cerevisiae, (sourdough bread and Lactobacilos (ATCC 90827LA10N19.10-E.U.A were applied. These reactions were carried out by using water as solvent at room temperature excelling for the Green Chemistry principles. Figure 1 shows the reaction scheme involving 1 eq.mol of aniline, 1,3 eq.mol of formaldehyde, 10 ml of water and 0,25g of the catalyst during four days. The reaction furnished satisfactory yields which are in accordance with the literature data.

  4. Mannich Bases: An Important Pharmacophore in Present Scenario

    Directory of Open Access Journals (Sweden)

    Suman Bala

    2014-01-01

    Full Text Available Mannich bases are the end products of Mannich reaction and are known as beta-amino ketone carrying compounds. Mannich reaction is a carbon-carbon bond forming nucleophilic addition reaction and is a key step in synthesis of a wide variety of natural products, pharmaceuticals, and so forth. Mannich reaction is important for the construction of nitrogen containing compounds. There is a number of aminoalkyl chain bearing Mannich bases like fluoxetine, atropine, ethacrynic acid, trihexyphenidyl, and so forth with high curative value. The literature studies enlighten the fact that Mannich bases are very reactive and recognized to possess potent diverse activities like anti-inflammatory, anticancer, antifilarial, antibacterial, antifungal, anticonvulsant, anthelmintic, antitubercular, analgesic, anti-HIV, antimalarial, antipsychotic, antiviral activities and so forth. The biological activity of Mannich bases is mainly attributed to α, β-unsaturated ketone which can be generated by deamination of hydrogen atom of the amine group.

  5. Stereoselective bioreduction of someMannich bases

    Directory of Open Access Journals (Sweden)

    Bruna S. D. R. Aranha

    2012-06-01

    Full Text Available The chemic reaction that happen on the live organism (plants, superior animals and microorganisms produce various chiral substances such as pheromones, antibiotics and others. After the eighties, with the break of the dogma referent to the enzymatic utilization only in aqueous medias, diverse enzyme application were revealed in other reaction medias, what allowed new studies turned to enzymatic application in organic chemistry. Such studies revealed that these biocatalysts presented high selectivity in these medias, no only about to the chemoselectivity but especially to the enantioselectivity. According to what was exposed, this work aimed to execute the bioreduction of some Mannich bases using the microorganism Saccharomyces cerevisiae (sourdough bread. Scheme 1 shows the reaction scheme involving 1 eq.mol of the b-aminocarbonilated product, 10 mL of   the suitable solvent and 0,5g of the biocatalys during four days at room temperature. These reactions presented satisfactory yields, which are in accordance with the literature.

  6. Claus Bonderup

    DEFF Research Database (Denmark)

    Fisker, Anna Marie; Hvejsel, Marie Frier; Tvedebrink, Tenna Doktor Olsen

    -oriented architectural projects within Urban Farming in which the students will initially work with the subject as master’s students, but later, hopefully, as PhD students. Also, I have wished for a long time to give Claus Bonderup the recognition he deserves! His view of architecture, his knowledge and his way...... house that serves as a basis for this project with its unique architectural models for the International Architecture Exhibition. Claus’ Duck House has, thus, in theory and practice alike, become the foundation for the new architectural models, and his thoughts on design have contributed to a fruitful...

  7. Are Subject Small Clauses Really Small Clauses?

    Science.gov (United States)

    Kubo, Miori

    1993-01-01

    This paper discusses the ongoing debate over small clauses concerning the structure of the verb phrase in "I consider Bill smart." It is demonstrated that the subject constituent in question is not a small clause, but a Noun Phrase (NP), following Noun (N). It is shown that some peculiar phenomena under the small clause analysis are natural…

  8. Covered Clause Elimination

    CERN Document Server

    Heule, Marijn; Biere, Armin

    2010-01-01

    Generalizing the novel clause elimination procedures developed in [M. Heule, M. J\\"arvisalo, and A. Biere. Clause elimination procedures for CNF formulas. In Proc. LPAR-17, volume 6397 of LNCS, pages 357-371. Springer, 2010.], we introduce explicit (CCE), hidden (HCCE), and asymmetric (ACCE) variants of a procedure that eliminates covered clauses from CNF formulas. We show that these procedures are more effective in reducing CNF formulas than the respective variants of blocked clause elimination, and may hence be interesting as new preprocessing/simplification techniques for SAT solving.

  9. Green chemistry approach to the synthesis of potentially bioactive aminobenzylated Mannich bases through active hydrogen compounds

    Directory of Open Access Journals (Sweden)

    S. L. VASOYA

    2005-10-01

    Full Text Available An efficient and high yield method for the synthesis of aminobenzylated Mannich bases is described. The synthesis occurs in aqueous medium at 0 ºC. The compounds show moderate antitubercular and antimicrobial activities.

  10. Lithium amide assisted asymmetric Mannich-type reactions of menthyl acetate with PMP-aldimines.

    Science.gov (United States)

    Hata, Seiji; Iguchi, Mayu; Iwasawa, Tetsuo; Yamada, Ken-ichi; Tomioka, Kiyoshi

    2004-05-27

    A lithium enolate of menthyl acetate added to PMP-imines, in the presence of an equimolar amount of lithium diisopropylamide, affords the Mannich-type addition products in high stereoselectivity. [reaction--see text

  11. Promotion of a Ti-Mediated Mannich Reaction by a Proton Source.

    Science.gov (United States)

    Limanto, John; Yoshikawa, Naoki; Reamer, Robert A; Tan, Lushi; Brunskill, Andrew; Reibarkh, Mikhail

    2016-01-15

    Low temperature NMR studies revealed that a diastereoselective Mannich reaction between a phenyl oxazolidone-derived titanium enolate and an aromatic aldimine was found to occur only after introduction of a proton source. While various protic additives could be used to promote the transformation, the best results were obtained using AcOH to afford the corresponding Mannich products in high diastereoselectivities and yields. PMID:26656787

  12. Clause Types in Southeastern Tepehuan.

    Science.gov (United States)

    Willett, Thomas L.

    The clause in Southeastern Tepehuan consists of a predicate, its associated arguments, and other modifying elements. This paper seeks to show the various types of semantic and surface clauses and the relation between them. The semantic clause consists of various semantic components, both nuclear and peripheral, semantic prosodies, and certain…

  13. An Overview of Relative Clauses

    Institute of Scientific and Technical Information of China (English)

    肖飒

    2015-01-01

    Relative clause is one kind of important modifiers among English grammar. It is a widely used clauses in English con-text. In order to get an overview of relative clause, this essay will analyze it in terms of form, meaning and use.

  14. Iterative Specialisation of Horn Clauses

    DEFF Research Database (Denmark)

    Nielsen, Christoffer Rosenkilde; Nielson, Flemming; Nielson, Hanne Riis

    2008-01-01

    We present a generic algorithm for solving Horn clauses through iterative specialisation. The algorithm is generic in the sense that it can be instantiated with any decidable fragment of Horn clauses, resulting in a solution scheme for general Horn clauses that guarantees soundness and termination...

  15. Claus Achton Friis

    DEFF Research Database (Denmark)

    Ejlers, Steen

    1996-01-01

    Grafiker, professor Claus Achton Friis 1917-1999 er en central skikkelse i det 20.århundredes danske brugsgrafik. Han er ophavsmand til en mængde emballager, frimærker og heraldik og desuden formgiver af en række fremragende skrifter. Han var elev af grafikeren professor Gunnar Biilmann Petersen og...

  16. Synthesis and NO production inhibition of novel Mannich base derivatives of irisolidone

    Institute of Scientific and Technical Information of China (English)

    Jiao Wang; Ying Zhong; Lu Liu; Xin Quan Ji; Zhi Guo Zhang

    2008-01-01

    Five new C-8 Mannich base derivatives of irisolidone 2a-2e were synthesized and their nitric oxide (NO) production inhibitory activity was evaluated.Compounds 2a,2b,2c and 2e displayed stronger activities in vitro than the parent compound irisolidone.

  17. RUTHENIUM-CATALYZED TANDEM OLEFIN MIGRATION-ALDOL AND MANNICH-TYPE REACTIONS IN IONIC LIQUID.

    Science.gov (United States)

    In the presence of a catalytic amount of RuCl2(PPh3)3, a cross-coupling of 3-buten-2-ol with aldehydes and imines was developed via a tandem olefin migration--aldol--Mannich reaction in bmim[PF6]. With In(OAc)3 as a co-catalyst, a-vinylbenzyl alcohol and aldehydes underwent sim...

  18. ALDOL- AND MANNICH-TYPE REACTIONS VIA IN SITU OLEFIN MIGRATION IN IONIC LIQUID

    Science.gov (United States)

    An aldol-type and a Mannich-type reaction via the cross-coupling of aldehydes and imines with allylic alcohols catalyzed by RuCl2(PPh3)3 was developed with ionic liquid as the solvent. The solvent/catalyst system could be reused for at least five times with no loss of reactiv...

  19. Tandem Mannich/Diels–Alder reactions for the synthesis of indole compound libraries

    DEFF Research Database (Denmark)

    Wu, Peng; Petersen, Michael Åxman; Petersen, Rico;

    2016-01-01

    A tandem Mannich/Diels–Alder sequence for the synthesis of small-molecule libraries with an indolyl-octahydro-3a,6-epoxy-isoindole core structure is demonstrated in this study. Representative diversification examples based on this scaffold were performed, and a library is being produced within th...

  20. A Sustainable Protocol for the Aqueous Multicomponent Petasis Borono-Mannich Reaction

    Science.gov (United States)

    Candeias, Nuno R.; Paterna, Roberta; Cal, Pedro M. S. D.; Gois, Pedro M. P.

    2012-01-01

    A protocol for the preparation of Petasis borono-Mannich products suitable for advanced organic chemistry experiments, using water as a reaction medium, was developed. The experiment is carried out in less than 4 h (with a 30 min pre-session on the day before) using commercially available starting materials in the preparation of phenylglycine and…

  1. NMR study of the preparation of 6 {alpha}, 7 {beta}-dihydroxyvouacapan-17 beta-oic acid mannich base derivatives

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Flavio Jose Leite dos; Pilo-Veloso, Dorila [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte (Brazil). Inst. de Ciencias Exatas. Dept. Quimica]. E-mail: dorila@zeus.qui.ufmg.br; Ferreira-Alves, Dalton L. [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte (Brazil). Inst. de Ciencias Biologicas. Dept. de Farmacologia

    2007-07-01

    This work presents four new Mannich base compounds obtained by the Mannich reaction of a {delta}-keto-lactone derivative of 6{alpha}, 7{beta}-dihydroxyvouacapan- 17{beta}-oic acid, a furano diterpene isolated from the hexane extract of Pterodon polygalaeflorus Benth fruits, which shows anti-inflammatory and analgesic activities. The use of 1D and 2D NMR (COSY, DEPT-135, HMBC, HMQC) spectroscopy made it possible to characterize the new compounds. (author)

  2. Muscular Dystrophy (MD)

    Science.gov (United States)

    ... Awards Enhancing Diversity Find People About NINDS NINDS Muscular Dystrophy Information Page Clinical Trials Finding the Optimum Regimen ... en Español Additional resources from MedlinePlus What is Muscular Dystrophy? The muscular dystrophies (MD) are a group of ...

  3. Reação de Mannich: Metodologia Clássica na Formação de Ligação Carbono-Carbono

    Directory of Open Access Journals (Sweden)

    João Francisco Allochio Filho

    2013-08-01

    Full Text Available The Mannich reaction is a classical method for the preparation of b-aminoketones and aldeydes (Mannich bases and, as such, is one the most important reaction in organic chemistry. The resulting Mannich bases are of particular interest due to their biological activity, use as synthetic building blocks, and precursors of valuable pharmaceuticals products. In this context, various elegant stereoselective α-aminoalkylations have been developed.

  4. Collide and Squeeze MD

    CERN Document Server

    Gorzawski, Arkadiusz; Papotti, Giulia; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; Pieloni, Tatiana; CERN. Geneva. ATS Department

    2015-01-01

    Colliding the beams during the squeeze to profit from Landau damping due to head--on beam-beam and b* leveling are two operational modes that may have to be used in a not so distant future at the LHC. This MD aimed at improving the process control during the squeeze with much improved handling of reference for the orbit feedback system and at evaluating instruments and techniques to maintain the beam in collisions with active feedback on a good observable.

  5. Study on the Synthesis and Corrosion Inhibition Performance of Mannich-Modified Imidazoline

    Directory of Open Access Journals (Sweden)

    Xiangjun Kong

    2016-07-01

    Full Text Available A novel Mannich-modified imidazoline (MMI as cationic emulsifier was synthesised for corrosion harm reduction, through three steps — acylation, cyclization, and Mannich reaction. The surface activity was characterized by determination of surface tensions and critical micelle concentration (CMC. The corrosion inhibition performance of five types of steels in the simulated corrosion solution in the presence of the MMI was investigated by static weight loss tests. The results showed that the MMI had good surface activities, with CMC of 19.8 μg g−1 and surface tension of 36.4 mN m−1. The corrosion test results indicated that the corrosion rates of different materials were decreased significantly, and degrees of corrosion inhibition were always higher than 80.0 %. The main inhibition mechanism was most likely due to the adsorption of the corrosion inhibitor on the steel surface, leading to the prevention of corrosion medium from the metal surface.

  6. Trimerization catalysis of phenylisocyanate in the presence of phenolic mannich bases

    Energy Technology Data Exchange (ETDEWEB)

    Selivanov, A.V.; Zenitova, L.A.; Bakirova, I.N.; Kirpichnikov, P.A.

    1988-11-01

    The kinetics of the cyclic trimerization of phenylisocyanate in the presence of phenolic Mannich bases have been studied by IR spectroscopy; a catalysis mechanism for the reaction is proposed. It was found that in order for trimerization to occur the catalyst molecule must contain both a hydroxyl group and a tertiary nitrogen atom, which leads to reaction at the OH group of the catalyst and its conversion via a urethane derivative to an allophanate; the latter species undergoes tautomeric rearrangement to a bipolar ion, which is the actual catalysis site. The effects of the number of aminomethyl, hydroxyl, and other electron-donating and electron-withdrawing substituents on the structure of Mannich bases have also been investigated.

  7. Synthesis, Characterization and Biological Evaluation of 1, 2-Disubstituted Benzimidazole Derivatives using Mannich Bases

    OpenAIRE

    Reddy, B. Anil

    2010-01-01

    The ring system in which a benzene ring is fused to the 4,5-positions of imidazole is designated as benzimidazole. Condensations of 2-substituted benzimidazole derivatives were synthesized by different carboxylic acids using Mannich base and anti-inflammatory activity. The various positions on the benzimidazole ring are numbered in the manner indicated with the imino function as number one. The formations of the product were conformed by the analytical and spectral data.

  8. Structural studies on Mannich bases of 2-Hydroxy-3,4,5,6-tetrachlorobenzene. An UV, IR, NMR and DFT study. A mini-review

    DEFF Research Database (Denmark)

    Hansen, Poul Erik; Spanget-Larsen, Jens

    2016-01-01

    Mannich bases of 2-Hydroxy-3,4,5,6-tetrachlorobenzene are chosen as an exemplary case for tautomeric Mannich bases. Molecular structures are calculated. OH stretching frequencies are rationalized based on DFT calculations. Intrinsic deuterium isotope effects on 13C chemical shifts in the M...

  9. Defective Arbitration Clauses in International Commercial Contracts

    OpenAIRE

    Tolkušinas, Kasparas

    2011-01-01

    Usually in a drafting process of a contract arbitration clause is left at the end of a contract. Sometimes it happens that parties really do not wish start discussions on how should arbitration clause look like or what details should it contain, because either parties think they would never come to a conflict or they are short in time and leave arbitration clause unconsidered. Absence of proper attention when drafting arbitration clauses is likely to give rise to defective arbitration clauses...

  10. Modified Claus process probabilistic model

    Energy Technology Data Exchange (ETDEWEB)

    Larraz Mora, R. [Chemical Engineering Dept., Univ. of La Laguna (Spain)

    2006-03-15

    A model is proposed for the simulation of an industrial Claus unit with a straight-through configuration and two catalytic reactors. Process plant design evaluations based on deterministic calculations does not take into account the uncertainties that are associated with the different input variables. A probabilistic simulation method was applied in the Claus model to obtain an impression of how some of these inaccuracies influences plant performance. (orig.)

  11. Arnold Aberman, MD.

    Science.gov (United States)

    Aberman, A

    1995-10-01

    When the United States embarked on its effort to provide universal health insurance, the Canadian Medicare System was cited as a possible model for American health care. Often touted as an example of low-cost, high quality medicine, the Canadian system has mirrored the problems of health care across its southern border. With rocketing health care expenditures and financing having largely been decentralized to the individual provinces, local officials have struggled to cut costs and services. A central focus of these efforts has been a move to decrease the numbers of physicians, most notably a 10% decrease in medical school class size in 1993. While some Western provinces have experimented with the privatization of health care, the Canadian system still remains the epitome of government operated fee-for-service medicine. Given the likelihood of dramatic change in the American Medicare system, Canadian academic centers offer a unique perspective on the impact of capitation, evolving relationships with government payors, and the flip side of market oriented reforms. At the helm of one of Canada's largest schools is Arnold Aberman, MD, dean of the University of Toronto Faculty of Medicine. Born in Montreal, Quebec, Aberman received his MD from McGill University, but then did his residency both in Canada and the US, followed by a pulmonary fellowship at Albert Einstein College of Medicine and the Cardiovascular Research Institute of the University of California, San Francisco. Interviewed at his office in Toronto, Aberman reflected on the trials and tribulations confronting medicine on both sides of the 48th parallel.

  12. ADT fast losses MD

    CERN Document Server

    Priebe, A; Dehning, B; Redaelli, S; Salvachua Ferrando, BM; Sapinski, M; Solfaroli Camillocci, M; Valuch, D

    2013-01-01

    The fast beam losses in the order of 1 ms are expected to be a potential major luminosity limitation for higher beam energies after the LHC long shutdown (LS1). Therefore a Quench Test is planned in the winter 2013 to estimate the quench limit in this timescale and revise the current models. This experiment was devoted to determination the LHC Transverse Damper (ADT) as a system for fast losses induction. A non-standard operation of the ADT was used to develop the beam oscillation instead of suppressing them. The sign flip method had allowed us to create the fast losses within several LHC turns at 450 GeV during the previous test (26th March 2012). Thus, the ADT could be potentially used for the studies of the UFO ("Unidentied Falling Object") impact on the cold magnets. Verification of the system capability and investigations of the disturbed beam properties were the main objectives of this MD. During the experiment, the pilot bunches of proton beam were excited independently in the horizontal and vertical ...

  13. MD5算法研究%MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    张裔智; 赵毅; 汤小斌

    2008-01-01

    随着网络技术的迅速发展,信息加密技术已成为保障网络安全的一种重要手段,加密算法已经成为人们的一个研究热点.本文对MD5算法进行了深入研究,介绍MD5算法的产生背景、应用及其算法流程,并提出了MD5算法的一个改进方案.

  14. 48 CFR 3019.708 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Contract clauses. 3019.708... ACQUISITION REGULATION (HSAR) SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 3019.708 Contract clauses....

  15. 48 CFR 16.307 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... commercial item) is contemplated. If the contract is with an educational institution, modify the clause by... AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 16.307 Contract clauses. (a)(1)...

  16. 48 CFR 3.1004 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Contractor Code of Business Ethics and Conduct 3.1004 Contract clauses. (a) Insert the clause at FAR 52.203-13, Contractor Code of Business Ethics and...

  17. 48 CFR 1632.617 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... HEALTH BENEFITS ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Debts 1632.617 Contract clause. The clause at (FAR) 48 CFR 52.232-17 will be modified in all FEHBP...

  18. Solving non-linear Horn clauses using a linear Horn clause solver

    DEFF Research Database (Denmark)

    Kafle, Bishoksan; Gallagher, John Patrick; Ganty, Pierre

    2016-01-01

    In this paper we show that checking satisfiability of a set of non-linear Horn clauses (also called a non-linear Horn clause program) can be achieved using a solver for linear Horn clauses. We achieve this by interleaving a program transformation with a satisfiability checker for linear Horn...... clauses (also called a solver for linear Horn clauses). The program transformation is based on the notion of tree dimension, which we apply to a set of non-linear clauses, yielding a set whose derivation trees have bounded dimension. Such a set of clauses can be linearised. The main algorithm...

  19. Synthesis and Anticonvulsant Activity of Various Mannich and Schiff Bases of 1,5-Benzodiazepines

    Directory of Open Access Journals (Sweden)

    Surendra N. Pandeya

    2012-01-01

    Full Text Available Benzodiazepines have a various behavioral effects in addition to their anxiolytic action. There is every reason to believe that the BZ/GABA receptor complex is involved in these effects, since GABAmimetic manipulations modify the effect of BZ in tests of convulsive activity, motor function, and appetitive behavior. 1,5-Benzodiazepines are biologically important molecules and are extensively used clinically as analgesic, hypnotic, sedative, and antidepressive agents. Hence, 1,5-Benzodiazepines were synthesized by condensation of o-phenylenediamine and ketones, for example, cyclohexanone and acetone in presence of sulfated zirconia (catalyst. Mannich bases were synthesized with acetophenone, p-nitroacetophenone, p-chloroacetophenone, and formaldehyde. Schiff bases were synthesized using Mannich base of 1,5-benzodiazepines with p-chloroaniline and p-chlorophenylsemicarbazide in the presence of glacial acetic acid. All the synthesized compounds were characterized by 1H NMR and IR spectral analyses. All the synthesized derivatives were evaluated at the dose of 30 mg/kg b.w for anticonvulsant activity by isoniazid induced convulsion model, and the compounds NBZD-3 and NBZD-8 were found to be the most active among all compounds. Among all the synthesized derivatives, compounds NBZD-13 and NBZD-17 were found to be the most active among all compounds using thiosemicarbazide induced model. Although NBZD-8, NBZD-10, and NBZD-18 are the compounds which had shown good anticonvulsant activity and have an advantage over that, they were not sedative.

  20. 48 CFR 923.903 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 923.903... Environmental Management Systems § 923.903 Contract clause. The FAR Environmental Management Systems clause at 52.223-XX should be used in contracts where the contractor operates a DOE site or portion...

  1. 48 CFR 53.111 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Contract clause. 53.111... AND FORMS FORMS General 53.111 Contract clause. Contracting officers shall insert the clause at 52.253-1, Computer Generated Forms, in solicitations and contracts that require the contractor to...

  2. 48 CFR 811.503 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 811.503... ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Liquidated Damages 811.503 Contract clause. When the contracting... contracting officer must include the clause in 852.211-74, Liquidated damages, in the contract....

  3. 48 CFR 903.971 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 903.971... Contract clause. The contracting officer shall insert the clause at 952.203-70, Whistleblower Protection for Contractor Employees, in contracts that involve work to be done on behalf of DOE directly...

  4. 48 CFR 837.403 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 837.403... OF CONTRACTING SERVICE CONTRACTING Nonpersonal Health Care Services 837.403 Contract clause. The contracting officer shall insert the clause at 852.237-7, Indemnification and medical liability insurance,...

  5. 48 CFR 822.305 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 822.305... PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Contract Work Hours and Safety Standards Act 822.305 Contract clause. The contracting officer shall insert the clause at 852.222-70, Contract...

  6. 48 CFR 19.1407 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clauses. 19.1407... PROGRAMS SMALL BUSINESS PROGRAMS Service-Disabled Veteran-Owned Small Business Procurement Program 19.1407 Contract clauses. The contracting officer shall insert the clause 52.219-27, Notice of Total...

  7. 48 CFR 19.1104 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clause. 19.1104... PROGRAMS SMALL BUSINESS PROGRAMS Price Evaluation Adjustment for Small Disadvantaged Business Concerns 19.1104 Contract clause. Insert the clause at 52.219-23, Notice of Price Evaluation Adjustment for...

  8. 48 CFR 819.7009 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 819.7009... PROGRAMS SMALL BUSINESS PROGRAMS Service-Disabled Veteran-Owned and Veteran-Owned Small Business Acquisition Program 819.7009 Contract clauses. The contracting officer shall insert VAAR clause...

  9. 48 CFR 219.708 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... OF DEFENSE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 219.708 Contract clauses. (b)(1)(A) Use the clause at 252.219-7003, Small Business Subcontracting Plan... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clauses....

  10. 48 CFR 2103.571 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... GROUP LIFE INSURANCE FEDERAL ACQUISITION REGULATION GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Other Improper Business Practices 2103.571 Contract clause. The clause at 2152.203-70... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clause....

  11. 48 CFR 819.709 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 819.709 Contract clause. The contracting officer shall insert VAAR clause 852.219-9, Small Business Subcontracting Plan Minimum... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause....

  12. 48 CFR 803.7001 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 803.7001... BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Contractor Responsibility to Avoid Improper Business Practices 803.7001 Contract clause. The contracting officer shall insert the clause at 852.203-71,...

  13. 48 CFR 19.1308 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clauses. 19.1308... PROGRAMS SMALL BUSINESS PROGRAMS Historically Underutilized Business Zone (HUBZone) Program 19.1308 Contract clauses. (a) The contracting officer shall insert the clause 52.219-3, Notice of Total HUBZone...

  14. 48 CFR 203.1004 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... OF DEFENSE GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Contractor Code of Business Ethics and Conduct 203.1004 Contract clauses. (a) Use the clause at 252.203-7003 in solicitations and contracts that include the FAR clause 52.203-13, Contractor Code of Business Ethics and...

  15. 48 CFR 32.908 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clauses. 32.908... REQUIREMENTS CONTRACT FINANCING Prompt Payment 32.908 Contract clauses. (a) Insert the clause at 52.232-26... specify a period longer than 7 days for constructive acceptance or constructive approval, if required...

  16. 48 CFR 233.215 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clause. 233.215....215 Contract clause. Use Alternate I of the clause at FAR 52.233-1, Disputes, when— (1) The... (v) Tracked combat vehicles (vi) Related electronic systems; (2) The contracting officer...

  17. Relative Clauses in Classical Nahuatl

    Science.gov (United States)

    Langacker, Ronald W.

    1975-01-01

    Jane Rosenthal's paper on relative clauses in Classical Nahuatl is discussed, and it is argued that she misses an important generalization. An alternative analysis to a class of relative pronouns and new rules for the distribution of relative pronouns are proposed. (SC)

  18. Constraint Specialisation in Horn Clause Verification

    DEFF Research Database (Denmark)

    Kafle, Bishoksan; Gallagher, John Patrick

    2015-01-01

    We present a method for specialising the constraints in constrained Horn clauses with respect to a goal. We use abstract interpretation to compute a model of a query-answer transformation of a given set of clauses and a goal. The effect is to propagate the constraints from the goal top......-down and propagate answer constraints bottom-up. Our approach does not unfold the clauses at all; we use the constraints from the model to compute a specialised version of each clause in the program. The approach is independent of the abstract domain and the constraints theory underlying the clauses. Experimental...

  19. Synthesis of some derivatives of compounds β-aminoketonic through Mannich reaction by usingbiocatalysts

    Directory of Open Access Journals (Sweden)

    Ana Claudia S. Lima

    2012-06-01

    Full Text Available The Mannich reaction is one of the most widely used reactions in organic chemistry, and also one of the first examples of a multicomponent reaction already described on the literature. This reaction results in β-aminocarbonylated compounds which allow the generation of several structures that can be used in the synthesis of both biologically active molecules, and natural products, however, just a few synthetic routes resulting in the formation of β-aminocarbonylated compound are known. In this sense, new methodologies have been developed by involving new catalysts or chiral auxiliaries in the synthesis of β-aminocarbonylated compounds with biological activity. One of these methodologies is the biocatalysis, which is a technique that uses biological catalysts, like enzymes or micro-organisms to convert a substrate in a limited number of enzymatic steps. The use of micro-organisms, plants or isolated enzymes as chiral catalysts has proportioned a significant advance in the synthetic chemistry, because it is known that the biocatalysts have selective catalytic sites that afford the formation of enantiomerically pure products and which is extremely important, because it is known that differences of the chirality may have tragic or spectacular effects in humans. Concerning to the environmental issue, the biocatalysis is placed within the context of a new philosophy called Green Chemistry. However, in the State of Mato Grosso do Sul the researches involving this issue of biocatalysis are still incipient once that by the year of 2010 there was only one research group focused on this themeregistered in the Lattes Platform in the State. Because of the need of support to the researches focused on this issue in the State of Mato Grosso do Sul and to evaluate thebiocatalytic potential of different lineage of microorganisms and enzymes in the synthesis of compounds β-aminoketonic through Mannich reaction it was proposed the use of someenzymes such as

  20. Synthesis and Biological Activity of 1,3,4-Oxadiazole Mannich Bases Containing Pyrimidine Rings%含嘧啶环的1,3,4-噁二唑 Mannich 碱的合成及生物活性

    Institute of Scientific and Technical Information of China (English)

    沈生强; 孙晓红; 刘源发; 陈邦; 靳如意; 马海霞

    2014-01-01

    1,3,4-Oxadiazole derivatives were reported to possess a broad spectrum of biological activities, such as antifungal, antibacterial, antiviral and antitubercular. Mannich bases had also been reported as poten-tial biological agents, they were applicated in the fields of synthetic study and medicinal chemistry. In recent years, Mannich bases containing 1,3,4-oxadiazole ring had attracted a lot of attention and many Mannich ba-ses of 1,3,4-oxadiazole bearing heterocycle scaffold were reported to have special bioactivity. Nevertheless, literature revealed that there were no reports of a molecular scaffold that Mannich base of 1,3,4-oxadiazole bearing pyrimidine. Prompted by these observations, a series of 1,3,4-oxadiazole derivatives containing py-rimidine( E1-E15) was synthesized from 5-aryl-1,3,4-oxadiazole-2-thione ( C1-C3), formaldehyde and substituted aminopyrimidine ( D1-D5) by Mannich reaction. 5-Aryl-1,3,4-oxadiazole-2-thione derivatives (C1-C3) were prepared from aromatic acids as the starting material via esterification, hydrazinolysis and cy-clization. The structures of all title compounds were confirmed by elemental analysis, IR, 1 H NMR tech-niques. Furthermore, their biological activities to four vegetable pathogens containing Gibberll nicotiancola, Gibberlla saubinetii, Fusarium oxysporium f. sp. niveum, Pythium solani had been tested. The preliminary re-sults indicated that most of the compounds exhibit relatively good fungicidal activities, especially compounds E3 and E8 showed better biological activity than triazolone.%以芳香酸为原料,通过酯化、肼解及环化反应制得中间体5-芳基取代-1,3,4-噁二唑-2-硫酮(C1~C3),然后中间体与甲醛和取代氨基嘧啶(D1~ D5)发生 Mannich 反应得到一系列新型含有嘧啶环的1,3,4-噁二唑类衍生物(E1~ E15)。所得目标化合物的结构经元素分析、 IR 及1 H NMR 确认。初步的生物活性测定结果表明,大部分目标化合物对植物病原菌有很好

  1. A new Mannich base and its transition metal (II) complexes - Synthesis, structural characterization and electrochemical study

    Indian Academy of Sciences (India)

    N Raman; S Esthar; C Thangaraja

    2004-06-01

    new Mannich base, N-(1-morpholinobenzyl) semicarbazide (MBS), formed by the condensation of morpholine, semicarbazide and benzaldehyde, and its Cu(II), Ni(II), Co(II) and Zn(II) complexes have been synthesized. Their structures have been elucidated on the basis of analytical, magnetic, electrical conductivity and spectral study as well as elemental analyses. The complexes exhibit square-planar geometry. The monomeric and non-electrolytic nature of the complexes is evidenced by their magnetic susceptibility and low conductance data. The electrochemical property of the ligand and its complexes in acetonitrile solution was studied by cyclic voltammetry. The X-band ESR spectra of the Cu(II) complex in DMSO at 300 and 77 K were recorded and their salient features are reported.

  2. Stereoselectivities in α- and β-Amino Acids Catalyzed Mannich Reactions Involving Cyclohexanone

    Institute of Scientific and Technical Information of China (English)

    WANG Ying; FU Ai-ping; LI Hong-liang; TIAN Feng-hui; YUAN Shu-ping; SI Hong-zong; DUAN Yun-bo; WANG Zong-hua

    2011-01-01

    The effects of two different amino acid catalysts on the stereoselectivities in the direct Mannich reactions of cyclohexanone,p-anisidine and p-nitrobenzaldehyde were studied with the aid of density functional theory.Transition states of the stereo-determining C-C bond-forming step with the addition of enamine intermediate to the imine for the L-proline(α-amino acid) and (R)-3-pyrrolidinecarboxylic acid(β-amino acid)-catalyzed processes were reported.B3LYP/6-31G** calculations provide a good explanation for the opposite syn vs.anti diastereoselectivities of these two different kinds of catalysts(syn-selectivity for the α-amino acid catalysts,anti-selectivity for the β-amino acid catalysts).Calculated and observed diastereomeric ratio and enantiomeric excess values are in reasonable agreement.

  3. Investigation of biological effects of some Mannich Bases containing Bis-1,2,4- Triazole.

    Science.gov (United States)

    Parlak, A E; Celik, S; Karatepe, M; Turkoglu, S; Alayunt, N O; Dastan, S D; Ulas, M; Sandal, S; Tekin, S; Koparir, M

    2016-01-01

    In this study, the effects of Mannich bases containing bis-1,2,4-triazole on the levels of in vivo malondialdehyde (MDA) and antioxidant vitamins (A, E, C) were examined in serum, livers and kidneys of rats. DA and vitamin (A, E, C) levels were determined by high performance liquid chromatography (HPLC). Antioxidant effect was investigated by determining the MDA levels in Saccharomyces cerevisiae cells as in vitro. Furthermore, the antitumor effects of compounds were investigated against MCF-7 human breast cancer cells. Interrelations of results among control and compound groups were evaluated using SPSS statistical software package. As a result, some of the compounds showed effective biological activity when compared to control conditions. The test compounds used in this study may be effective for utilization in the selection and design of model compounds for further studies. PMID:27453272

  4. 78 FR 14547 - Praxedes E. Alverez Santiago, M.D., Daniel Perez Brisebois, M.D., Jorge Grillasca Palou, M.D...

    Science.gov (United States)

    2013-03-06

    ... Praxedes E. Alverez Santiago, M.D., Daniel Perez Brisebois, M.D., Jorge Grillasca Palou, M.D., Rafael..., M.D., Daniel P rez Brisebois, M.D., Jorge Grillasca Palou, M.D., Rafael Garc a Nieves, M.D., Francis... and Dr. Daniel Perez, met with Humana representatives to discuss the 20 percent COB. During...

  5. Inhibition of Mild Steel Corrosion in 1M H2SO4 Medium by Benzimidazole Mannich bases

    Directory of Open Access Journals (Sweden)

    P. M. Dasami

    2015-03-01

    Full Text Available The corrosion inhibition behaviour of two synthesized Mannich bases has been investigated for mild steel in 1M H2SO4 by weight loss and electrochemical techniques.The inhibition efficiency depends on concentration of the inhibitor and temperature. The inhibitors function by adsorption on mild steel surface and obey Langmuir isotherm indicating monolayer adsorption on the surface. Thermodynamic parameters show that the adsorption of the inhibitors occurs through electrostatic interaction. Polarization studies reveal that the inhibitors behave as mixed type in 1M H2SO4 affecting both anodic metal dissolution and cathodic hydrogen evolution. SEM studies show the formation of surface adsorptive film of the Mannich bases on the mild steel surface.

  6. RELATIVE CLAUSES FROM ENGLISH TO ALBANIAN

    Directory of Open Access Journals (Sweden)

    Suela Koça

    2016-09-01

    Full Text Available This paper aims to describe the use of relative clauses in English and Albanian by comparing different clause types. Some theoretical issues addressed in this article include the definition of relative clauses, the relativized elements, and the use of relative pronouns and adverbs in both languages. Distinctions and similarities are identified by analyzing the way in which these clauses are translated from English into Albanian. The theoretical part is illustrated by examples extracted from “Animal Farm” by George Orwell and “Pride and Prejudice” by Jane Austin, and their translated versions in Albanian, “Ferma e Kafshëve” and “Krenari dhe Paragjykime”.

  7. 21 CFR 26.21 - Safeguard clause.

    Science.gov (United States)

    2010-04-01

    ... OF PHARMACEUTICAL GOOD MANUFACTURING PRACTICE REPORTS, MEDICAL DEVICE QUALITY SYSTEM AUDIT REPORTS... Specific Sector Provisions for Pharmaceutical Good Manufacturing Practices § 26.21 Safeguard clause....

  8. Synthesis of the reported structure of piperazirum using a nitro-Mannich reaction as the key stereochemical determining step

    Directory of Open Access Journals (Sweden)

    James C. Anderson

    2013-08-01

    Full Text Available Piperazirum, isolated from Arum palaestinum Boiss, was originally assigned as r-3,c-5-diisobutyl-c-6-isopropylpiperazin-2-one. The reported structure was synthesised diastereoselectively using a key nitro-Mannich reaction to set up the C5/C6 relative stereochemistry. The structure was unambiguously assigned by single crystal X-ray diffraction but the spectroscopic data did not match those reported for the natural product. The structure of the natural product must therefore be revised.

  9. SYNTHESIS OF BIS-PYRIMIDO IMIDAZOLE FUSED RING HETEROCYCLIC ADDUCT WITH UREAS OF MANNICH BASE FOR CNS DEPRESSION

    Directory of Open Access Journals (Sweden)

    AVANI H. SHETH*, PARIMAL M. PRAJAPATI, YATRI R. SHAH AND DHRUBO JYOTI SEN

    2009-12-01

    Full Text Available Mannich bases as well as urea derivatives have potent CNS depression activity. In our project work we have chosen aCNS drug which blocks the GABA receptor as well as chloride channel. Benzodiazepines have closed chain amidelinkage which acts on GABA (gamma amino butyric acid receptor and produces CNS depression with the blockageof chloride channel. This receptor has free amino and carboxylic acid functional group which produces amide linkagein-vivo.

  10. Synthesis of Arctigenin Mannich Derivative%牛蒡苷元曼尼希反应产物的合成

    Institute of Scientific and Technical Information of China (English)

    徐煜彬; 窦德强

    2013-01-01

    目的:合成牛蒡苷元曼尼希反应产物4-(3″,4″-二甲氧苄基)-3-(4′-羟基-3'-甲氧基-5′-(哌啶-1-基甲基)苯甲基)二氢呋喃-2 (3H)-酮.方法:本实验采用曼尼希的方法对牛蒡苷元酚羟基邻位进行结构修饰,牛蒡苷元与哌啶溶液反应合成曼尼希反应产物.结论:通过对合成工艺条件进行较为详细的考察,确定最佳工艺条件.%Objective:4-(3",4"-dimethoxybenzyl)-3-(4'-hydroxy-3'-methoxy-5'-(piperidin-1-ylmethyl) benzyl) dihydrofuran-2 (3H)-one,Mannich derivative of arctigenin was yielded.Method:Structure modification in phenolic hydroxyl group Ortho of arctigenin with Mannich method was carried out.The Mannich derivative was synthesized by treating arctigenin and piperidine solution.Conclusion:The art of the synthesis process was investigated in detail to determine the optimal process conditions.

  11. Identification of Mannich Base as a Novel Inhibitor of Mycobacterium Tuberculosis Isocitrate by High-Throughput Screening

    Directory of Open Access Journals (Sweden)

    Lei Ji, Quanxin Long, Dacheng Yang, Jianping Xie

    2011-01-01

    Full Text Available Mycobacterium tuberculosis (MTB remains one of the most significant human pathogens since its discovery in 1882. An estimated 1.5 million people died from tubercle bacillus (TB in 2006, and globally, there were an estimated 9.27 million incident cases of TB in 2007. Glyoxylate bypass pathway occurs in a wide range of pathogens and plays a key role in the pathogenesis of Mycobacterium tuberculosis. Isocitrate lyase (ICL can catalyses the first step of this pathway, and reversibly cleaves isocitrate into succinate and glyoxylate. So, ICL may represent a good drug target for the treatment of tuberculosis. ICL was cloned, expressed, and purified, and a high-throughput screen (HTS developed to screen active molecule from a mannich base compounds library for inhibition of ICL. This assay had signal to noise (S/N of 650.6990 and Z' factor of 0.8141, indicating that the assay was suitable for HTS. Screening of a collection of 124 mannich base compounds resulted in the identification of one mannich base compound, which has a significant inhibitory activity. So, a new family of compound was first reported to inhibit the activity of Mycobacterium tuberculosis ICL. This family of compound might offer new avenue to explore better anti-tuberculosis and fungi drugs.

  12. Santa Claus ’Names

    Institute of Scientific and Technical Information of China (English)

    寒冰

    2005-01-01

    A ustria—Christkind Belgium and the N etherlands—N oel Saint Nicholas C hristkind and Black Pete Brazil—Papa;N oel D enm ark—Julinisse England—Father Christm as Finland—O ld M an C hristm asFrance—Pere N oel or le Petit Germ any—K riss Kringle Christkind or Saint N icholas Italy—B efana Japan—Santa K urohsu M exico—Three Kings Poland—Star M an or W ise M en Spain—Three Kings R ussia—B asbouschka ?Santa Claus ’Names@寒冰

  13. 48 CFR 13.303-4 - Clauses.

    Science.gov (United States)

    2010-10-01

    .... (a) The contracting officer shall insert in each BPA the clauses prescribed elsewhere in this part that are required for or applicable to the particular BPA. (b) Unless a clause prescription specifies..., the amount to be compared to that threshold is that of any particular order under the BPA....

  14. 48 CFR 811.404 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 811.404... ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Delivery or Performance Schedules 811.404 Contract clause. When delivery is required by or on a particular date for f.o.b. destination contracts, the contracting...

  15. 48 CFR 704.404 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 704.404... ADMINISTRATIVE MATTERS Safeguarding Classified Information Within Industry 704.404 Contract clause. If the contract involves access to classified (“Confidential”, “Secret”, or “Top Secret”), or...

  16. 48 CFR 833.215 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 833.215 Section 833.215 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL CONTRACTING REQUIREMENTS PROTESTS, DISPUTES, AND APPEALS Disputes and Appeals 833.215 Contract clause. The...

  17. 48 CFR 519.708 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract clauses. 519.708 Section 519.708 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 519.708 Contract clauses....

  18. 48 CFR 1019.708 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1019.708 Section 1019.708 Federal Acquisition Regulations System DEPARTMENT OF THE TREASURY SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 1019.708 Contract clauses....

  19. 48 CFR 19.708 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 19.708 Contract clauses. (a... affecting section 19.708, see the List of CFR Sections Affected, which appears in the Finding Aids section... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clauses....

  20. 48 CFR 511.404 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract clauses. 511.404... ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Delivery or Performance Schedules 511.404 Contract clauses. In... shelf-life period is 12 months or less, and lengthy acceptance testing may be involved. For items...

  1. 48 CFR 716.406 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 716.406 Section 716.406 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost Reimbursement Contracts 716.406 Contract clauses....

  2. 48 CFR 1316.406 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1316.406 Section 1316.406 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 1316.406 Contract clauses. Insert a...

  3. 48 CFR 32.412 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clause. 32.412 Section 32.412 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING... rapid liquidation appropriate, the contracting officer shall use the clause with its Alternate III....

  4. 48 CFR 532.908 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract clauses. 532.908... REQUIREMENTS CONTRACT FINANCING Prompt Payment 532.908 Contract clauses. (a) GSA has a FAR deviation that... Information for Electronic Funds Transfer Payment; and (iii) For which the order is placed, and the...

  5. 48 CFR 23.602 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clause. 23.602... DRUG-FREE WORKPLACE Notice of Radioactive Material 23.602 Contract clause. The contracting officer..., aircraft, ammunition, missiles, vehicles, electronic tubes, instrument panel gauges, compasses...

  6. 48 CFR 232.7004 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Electronic Submission and Processing of Payment Requests and Receiving Reports 232.7004 Contract clause. Except as provided in 232.7002(a... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clause....

  7. 48 CFR 538.273 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract clauses. 538.273... Schedules 538.273 Contract clauses. (a) Multiple award schedules. Insert in solicitations and contracts: (1) 552.238-70, Identification of Electronic Office Equipment Providing Accessibility for the...

  8. 48 CFR 2446.710 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... Performance Specifications or Design Criteria, whenever it is in the Government's interest. ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clauses. 2446.710... CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 2446.710 Contract clauses. (c)(1) The contracting...

  9. 48 CFR 23.1005 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Federal Compliance With Right-To-Know Laws and Pollution Prevention Requirements 23.1005 Contract clause. (a) Insert the clause at 52.223-5, Pollution Prevention and...

  10. Sulphur condensation influence in Claus catalyst performance.

    Science.gov (United States)

    Mora, R L

    2000-12-01

    The Claus process is an efficient way of removing H(2)S from acid gas streams and this is widely practised in industries such as natural gas processing, oil refining and metal smelting. Increasingly strict pollution control regulations require maximum sulphur recovery from the Claus unit in order to minimise sulphur-containing effluent. The most widely used Claus catalyst in sulphur recovery units is non-promoted spherical activated alumina. Properties associated with optimum non-promoted Claus catalyst performance include high surface area, appropriate pore size distribution and enhanced physical properties. The objective of this paper is to outline a procedure in order to estimate Claus catalyst effectiveness after pore plugging due to sulphur condensation. Catalyst deactivation due to pore plugging by sulphur is modelled employing a Bethe lattice and its corresponding performance is described by means of a modified effectiveness factor. Model results show an improvement in the modified effectiveness factor due to modifications in catalyst porous structure.

  11. MD 751: Train Instability Threshold

    CERN Document Server

    Carver, Lee Robert; Metral, Elias; Salvant, Benoit; Levens, Tom; Nisbet, David; Zobov, M; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the octupole current thresholds for stability for a single bunch, and then make an immediate comparison (with the same operational settings) for a train of 72 bunches separated by 25ns. From theory, the expected thresholds should be similar. Any discrepancy between the two cases will be of great interest as it could indicate the presence of additional mechanisms that contribute to the instability threshold, for example electron cloud.

  12. Synthesis and Biological Evaluation of New Eugenol Mannich Bases as Promising Antifungal Agents.

    Science.gov (United States)

    Abrão, Pedro Henrique O; Pizi, Rafael B; de Souza, Thiago B; Silva, Naiara C; Fregnan, Antonio M; Silva, Fernanda N; Coelho, Luiz Felipe L; Malaquias, Luiz Cosme C; Dias, Amanda Latercia T; Dias, Danielle F; Veloso, Marcia P; Carvalho, Diogo T

    2015-10-01

    New Mannich base-type eugenol derivatives were synthesized and evaluated for their anticandidal activity using a broth microdilution assay. Among the synthesized compounds, 4-allyl-2-methoxy-6-(morpholin-4-ylmethyl) phenyl benzoate (7) and 4-{5-allyl-2-[(4-chlorobenzoyl)oxy]-3-methoxybenzyl}morpholin-4-ium chloride (8) were found to be the most effective antifungal compounds with low IC50 values, some of them well below those of reference drug fluconazole. The most significant IC50 values were those of 7 against C. glabrata (1.23 μm), C. albicans and C. krusei (both 0.63 μm). Additionally, the synthesized compounds were evaluated for their in vitro cytotoxic effects on human mononuclear cells. As result, the cytotoxic activity of eugenol in eukaryotic cells decreased with the introduction of the morpholinyl group. Given these findings, we point out compounds 7 and 8 as the most promising derivatives because they showed potency values greater than those of eugenol and fluconazole and they also presented high selectivity indexes.

  13. Synthesis and Biological Evaluation of Scutellaria Flavone Cyclaneaminol Mannich Base Derivatives as Novel CDK1 Inhibitors.

    Science.gov (United States)

    Ha, Lisha; Qian, Yuan; Zhang, Shixuan; Ju, Xiulan; Sun, Shiyou; Guo, Hongmin; Wang, Qianru; Li, Kangjian; Fan, Qingyu; Zheng, Yang; Li, Hailiang

    2016-01-01

    Cyclin-dependent kinase 1 (CDK1) is the only necessary CDK in the cell proliferation process and a new target in the research and development of anti-cancer drugs. Natural flavones are selective CDK1 inhibitors which can suppress the proliferation of cancer cells. However, their bioavailability is poor. To solve these problems, 6 Scutellaria flavones were isolated from hydrolyzed products of Scutellaria baicalensis and used as lead compounds, 18 Scutellaria flavones cyclane-aminol Mannich base derivatives were semi-synthesized and their biological activity as novel CDK1 inhibitors was evaluated. Results indicated that the biological activity of 8-Hydroxypiperidinemethyl-baicalein (BA-j) is the highest among these compounds. BA-j is a selective CDK1 inhibitor, and has broad-spectrum anti-proliferative activity in human cancer cells (IC50 12.3μM). BA-j can capture oxygen free radicals (.O2(-)) and selectively increase intracellular H2O2 level in cancer cells and activated lymphocytes, thus inducing their apoptosis rather than in normal cells. These findings suggest that BA-j selectively induces apoptosis in cancer and activated lymphocyte by controlling intracellular H2O2 level, and can be developed into a novel anti-proliferative agent for the treatment of cancer, AIDS, and some immune diseases. PMID:26411959

  14. Design, synthesis, and antimicrobial screening of novel pyridyl-2-amidrazone incorporated isatin mannich bases.

    Science.gov (United States)

    Kumar, N Saravana; Pradeep, T; Jani, G; Silpa, Divya; Kumar, B Vijaya

    2012-01-01

    Isatin is an endogenous compound and reported to possess a wide range of biological activities. Numerous papers have shown that the pyridyl-2-amidrazone nucleus possesses a potent antimicrobial activity. Based on these prior observations, we postulated that a compound containing both isatin and pyridyl-2-amidrazone pharmacophores could be very effective for antimicrobial activity. Unfavorable adsorption, distribution, metabolism, and excretion (ADME) properties can in many cases lead to the clinical trials failure of potentially successful drug candidates. Their evaluation, therefore, at an earlier stage is desired. Here, we also present the predicted ADME properties of our ligands through computation. All the compounds (2a(1-5)) exhibited a better solubility, diffusion, Log P, molecular weight, etc., with no violations making the ligands pharmacodynamically active and better oral absorptive series. Based on the results of computational design, a series of novel pyridyl-2-amidrazone-incorporated isatin Mannich bases were synthesized and screened for their antimicrobial activities. IR, (1)H-NMR, and Mass Spectroscopy data were consistent with the assigned structures. The results exhibited that all of the lead compounds showed good antimicrobial activities; noticeably, the compound 2a(2) showed the best activity against Candida albicans (16 μg/ml) and compound 2a(3) was found to be the most active derivative against Staphylococcus aureus and Escherichia coli at minimal inhibitory concentration values of 4 and 32 μg/ml, respectively. PMID:22470895

  15. Direct Catalytic Asymmetric Mannich-Type Reaction of α- and β-Fluorinated Amides.

    Science.gov (United States)

    Brewitz, Lennart; Arteaga, Fernando Arteaga; Yin, Liang; Alagiri, Kaliyamoorthy; Kumagai, Naoya; Shibasaki, Masakatsu

    2015-12-23

    The last two decades have witnessed the emergence of direct enolization protocols providing atom-economical and operationally simple methods to use enolates for stereoselective C-C bond-forming reactions, eliminating the inherent drawback of the preformation of enolates using stoichiometric amounts of reagents. In its infancy, direct enolization relied heavily on the intrinsic acidity of the latent enolates, and the reaction scope was limited to readily enolizable ketones and aldehydes. Recent advances in this field enabled the exploitation of carboxylic acid derivatives for direct enolization, offering expeditious access to synthetically versatile chiral building blocks. Despite the growing demand for enantioenriched fluorine-containing small molecules, α- and β-fluorinated carbonyl compounds have been neglected in direct enolization chemistry because of the competing and dominating defluorination pathway. Herein we present a comprehensive study on direct and highly stereoselective Mannich-type reactions of α- and β-fluorine-functionalized 7-azaindoline amides that rely on a soft Lewis acid/hard Brønsted base cooperative catalytic system to guarantee an efficient enolization while suppressing undesired defluorination. This protocol contributes to provide a series of fluorinated analogs of enantioenriched β-amino acids for medicinal chemistry. PMID:26652911

  16. 48 CFR 970.3270 - Standard financial management clauses.

    Science.gov (United States)

    2010-10-01

    ... Standard financial management clauses. (a) The following DEAR and FAR clauses are standard financial... Accounting Standards. (b) The following DEAR clauses are standard financial management clauses. The... systems: (1) 970.5232-7, Financial management system. (2) 970.5232-8, Integrated accounting. (c)...

  17. 48 CFR 52.252-2 - Clauses Incorporated by Reference.

    Science.gov (United States)

    2010-10-01

    ..., with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. Also, the full text of a clause may be accessed... (CONTINUED) CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses...

  18. The Information Structure of Adverbial Clauses in Chinese Discourse

    OpenAIRE

    Yu-Fang Wang

    2006-01-01

    This study investigated adverbial clauses in spoken as well as written Chinese discourse. The adverbial clauses in the spoken data were categorized into (i) initial clauses that occur in the initial position with respect to their linked material across continuing intonation, (ii) final clauses that occur in the final position with respect to their linked material across continuing intonation, and (iii) final clauses that occur in the final position with respect to their linked material across...

  19. Rh-Catalyzed reductive Mannich-type reaction and its application towards the synthesis of (±)-ezetimibe

    Science.gov (United States)

    Isoda, Motoyuki; Sato, Kazuyuki; Kunugi, Yurika; Tokonishi, Satsuki; Tarui, Atsushi; Minami, Hideki

    2016-01-01

    Summary An effective synthesis for syn-β-lactams was achieved using a Rh-catalyzed reductive Mannich-type reaction. A rhodium–hydride complex (Rh–H) derived from diethylzinc (Et2Zn) and a Rh catalyst was used for the 1,4-reduction of an α,β-unsaturated ester to give a Reformatsky-type reagent, which in turn, reacted with an imine to give the syn-β-lactam. Additionally, the reaction was applied to the synthesis of (±)-ezetimibe, a potent β-lactamic cholesterol absorption inhibitor. PMID:27559413

  20. A tandem Mannich addition–palladium catalyzed ring-closing route toward 4-substituted-3(2H-furanones

    Directory of Open Access Journals (Sweden)

    Jubi John

    2014-06-01

    Full Text Available A facile route towards highly functionalized 3(2H-furanones via a sequential Mannich addition–palladium catalyzed ring closing has been elaborated. The reaction of 4-chloroacetoacetate esters with imines derived from aliphatic and aromatic aldehydes under palladium catalysis afforded 4-substituted furanones in good to excellent yields. 4-Hydrazino-3(2H-furanones could also be synthesized from diazo esters in excellent yields by utilising the developed strategy. We could also efficiently transform the substituted furanones to aza-prostaglandin analogues.

  1. Synthesis of New Salen Ligands by Mannich Reaction%由Mannich反应合成新型Salen配体

    Institute of Scientific and Technical Information of China (English)

    王暖升; 李俊英; 李天铎

    2012-01-01

    以乙二胺或乙二胺衍生物为碱,与甲醛、对甲酚通过Mannich反应生成了四种N,N′-双(水杨醛)乙二胺(salen)配体,其中3个为新化合物.其结构经1H NMR,IR,MS和元素分析表征.%Four Salen ligangds(three of them are novel) were synthesized by Mannich condensation of ethanediamine or ethylenediamine derivatives with formaldehyde and p-cresol. The structures were characterized by 'H NMR, IR, MS and elemental analysis.

  2. 48 CFR 2432.908 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... commercial services awarded pursuant to FAR part 12. (2) The Contracting Officer shall insert a clause...-reimbursement type solicitations and contracts when vouchers are to be sent directly to the paying office....

  3. PENALTY CLAUSES WITHIN DIFFERENT LEGAL SYSTEMS

    Directory of Open Access Journals (Sweden)

    Simas Vitkus

    2013-06-01

    Full Text Available In this article the regulation in regard of penalty clauses within two different legal traditions, i.e. common law tradition and continental law tradition, is analyzed. In general a penalty clause implies a fixed sum, which has to be paid by a party for the failure to perform its contractual duties timely and duly. In common law world penalty clauses are rendered unenforceable, whereas civil law countries, including the Republic of Lithuania, consider such clauses enforceable to the extent that the stipulated amount is not excessive. Moreover, in the article attempts to reach a uniform regulation throughout various legal instruments are revealed. Purpose: to analyze the regulation of penalty clauses within different legal systems. Methodology: a systematic method was used in order to ascertain the content and true meaning of the legislation concerning penalty clauses, whereas comparative method allowed comparing such legislation among different jurisdictions. On the basis of analytical method conclusions were withdrawn. Findings: common law courts on the basis of just compensation principle may declare a clause, which stands for a penalty, unenforceable, whereas civil law courts may only reduce grossly excessive amount. However, under major soft law instruments, such as the UNIDROIT Principles , PECL and DCRF , the divergence from common law rules of non-enforcement of penalty clauses is evident. Although there is a lack of binding transnational rules that control the enforceability of penalty clauses across the countries, it seems that today the most feasible solution consists of the approval of national rules, which would shield the enforcement of penalties in international commercial contracts in common law jurisdictions. Research limitations: in the light of the civil law system terms of liquidated damages and penalty clause are used interchangeably, since both are enforceable. However, a distinction between the two can be made on the basis

  4. 48 CFR 416.670 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... CONTRACT TYPES TYPES OF CONTRACTS Time-and-Materials, Labor-Hour, and Letter Contracts 416.670 Contract clauses. The contracting officer shall limit the Government's obligation under a time-and-materials...

  5. Clause Elimination Procedures for CNF Formulas

    Science.gov (United States)

    Heule, Marijn; Järvisalo, Matti; Biere, Armin

    We develop and analyze clause elimination procedures, a specific family of simplification techniques for conjunctive normal form (CNF) formulas. Extending known procedures such as tautology, subsumption, and blocked clause elimination, we introduce novel elimination procedures based on hidden and asymmetric variants of these techniques. We analyze the resulting nine (including five new) clause elimination procedures from various perspectives: size reduction, BCP-preservance, confluence, and logical equivalence. For the variants not preserving logical equivalence, we show how to reconstruct solutions to original CNFs from satisfying assignments to simplified CNFs. We also identify a clause elimination procedure that does a transitive reduction of the binary implication graph underlying any CNF formula purely on the CNF level.

  6. Cavity Voltage Phase Modulation MD

    CERN Document Server

    Mastoridis, Themistoklis; Molendijk, John; Timko, Helga; CERN. Geneva. ATS Department

    2016-01-01

    The LHC RF/LLRF system is currently configured for extremely stable RF voltage to minimize transient beam loading effects. The present scheme cannot be extended beyond nominal beam current since the demanded power would exceed the peak klystron power and lead to saturation. A new scheme has therefore been proposed: for beam currents above nominal (and possibly earlier), the cavity phase modulation by the beam will not be corrected (transient beam loading), but the strong RF feedback and One-Turn Delay feedback will still be active for loop and beam stability in physics. To achieve this, the voltage set point will be adapted for each bunch. The goal of this MD was to test a new algorithm that would adjust the voltage set point to achieve the cavity phase modulation that would minimize klystron forward power.

  7. Cavity Voltage Phase Modulation MD

    CERN Document Server

    Mastoridis, T; Butterworth, A; Molendijk, J; Tuckmantel, J

    2012-01-01

    The LHC RF/LLRF system is currently setup for extremely stable RF voltage to minimize transient beam loading eects. The present scheme cannot be extended beyond nominal beam current since the demanded power would push the klystrons to saturation. For beam currents above nominal (and possibly earlier), the cavity phase modulation by the beam will be not be corrected (transient beam loading), but the strong RF feedback and One-Turn Delay feedback will still be active for loop and beam stability in physics. To achieve this, the voltage set point will be adapted for each bunch. The goal of this MD was to test an iterative algorithm that would adjust the voltage set point to achieve the optimal phase modulation for klystron forward power considerations.

  8. The Information Structure of Adverbial Clauses in Chinese Discourse

    Directory of Open Access Journals (Sweden)

    Yu-Fang Wang

    2006-06-01

    Full Text Available This study investigated adverbial clauses in spoken as well as written Chinese discourse. The adverbial clauses in the spoken data were categorized into (i initial clauses that occur in the initial position with respect to their linked material across continuing intonation, (ii final clauses that occur in the final position with respect to their linked material across continuing intonation, and (iii final clauses that occur in the final position with respect to their linked material across final intonation. Those in the written data were classified into (i initial and (ii final clauses that occur in the initial or final clauses that occur in the initial or final position, respectively, with respect to their main clauses. An analysis of the spoken and written data shows that the temporal, conditional, and concessiveclauses are quite different from the other adverbial clauses. Specifically, the causal clauses commonly appear in the final position with respect to their associated material in the spoken data, while the initial and final causal clauses are nearly evenly distributed in the written data. The data suggest that temporal, conditional, and concessive clauses, like topics, are presupposed parts of their sentences; i.e., all of them may be thought of as establishing frameworks for the interpretation of propositions that follow, which seem to be prototypically textual in their functioning. By contrast, causal clauses in Chinese are noticeably distinct from other adverbial clauses not only in spoken data, but also in written data; they play interactional as well as textual roles in discourse linking.

  9. Highly efficient synthesis of β-amino esters via Mannich-type reaction under solvent-free conditions using ZnCl2 catalyst

    Institute of Scientific and Technical Information of China (English)

    Xue Ming Chen; Xing Shu Li; Albert S.C. Chan

    2009-01-01

    β-Amino esters were synthesized via ZnCl2-catalyzed Mannich-type reaction of imines and malonate esters under solvent-free conditions in 6 min.The β-amino ester was converted into the corresponding aspartic acid derivatives.

  10. 2-methyl-3-butyn-2-ol as an acetylene precursor in the Mannich reaction. A new synthesis of suicide inactivators of monoamine oxidase

    International Nuclear Information System (INIS)

    A two-step reaction process is reported for the synthesis of 11C, 13C, or 14C-labelled propargylamines in moderate yields. The propargylamines were prepared by a modified Mannich scheme without the use of acetylene. The reaction scheme involved the use of 2-methyl-3-butyn-2-ol followed by KOH-catalyzed elimination of acetone from the acetylenic carbinols

  11. Highly efficient catalytic enantioselective Mannich reaction of malonates with N-tert-butoxycarbonyl imines by using Yb(OTf)3/pybox catalysts at room temperature.

    Science.gov (United States)

    Karimi, Babak; Jafari, Ehsan; Enders, Dieter

    2013-07-29

    Go Mannich! A highly efficient and enantioselective method for the direct asymmetric reaction of dibenzyl malonate with N-tert-butoxycarbonyl aldimines in the presence of Yb(OTf)3 and iPr-pybox complexes is described (see scheme; pybox = pyridine bisoxazoline).

  12. Synthesis of mono Mannich bases of 2-(4-hydroxybenzylidene)-2,3-dihydroinden-1-one and evaluation of their cytotoxicities.

    Science.gov (United States)

    Tugrak, Mehtap; Yamali, Cem; Sakagami, Hiroshi; Gul, Halise Inci

    2016-10-01

    Chalcones and Mannich bases are a group of compounds known for their cytotoxicities. In this study restricted chalcone analogue, compound 2-(4-hydroxybenzylidene)-2,3-dihydroinden-1-one MT1, was used as a starting compound to synthesize new mono Mannich bases since Mannich bases may induce more cytotoxicity than chalcone analogue that they are derived from by producing additional alkylating center for cellular thiols. In this study, cyclic and acyclic amines were used to synthesize Mannich bases. All compounds were tested against Ca9-22 (gingival carcinoma), HSC-2, HSC-3 and HSC-4 (oral squamous cell carcinoma) as tumour cell lines and HGF (gingival fibroblasts), HPC (pulp cells) and HPLF (periodontal ligament fibroblasts) human normal oral cells as non tumour cell lines. Cytotoxicity, selectivity index (SI) values and potency selectivity expression (PSE) values expressed as a percentage were determined for the compounds. According to data obtained, the compound MT8 with the highest PSE value bearing N-methylpiperazine moiety seems to be a good candidate to develop new cytotoxic compounds and is suited for further investigation. PMID:26247355

  13. Discriminative ability of two different external anchors: improvement appears better than importance

    DEFF Research Database (Denmark)

    Lauridsen, Henrik Hein

    Title:    Discriminative ability of two different external anchors: improvement appears better than importance. Authors and affiliation: Henrik H. Lauridsen, DC, MSc, PhD*, Claus Manniche, MD, DMSc‡, Werner Vach, PhD §, Niels Grunnet-Nilsson DC, MD, PhD*, Jan Hartvigsen, DC, PhD*†   * Clinical...... better discriminative abilities compared to the importance criterion. Consequently, we recommend using improvement and not importance as an anchor to determine the MIC....

  14. Discriminative ability of two different external anchors: improvement appears better than importance

    DEFF Research Database (Denmark)

    Lauridsen, Henrik Hein

    2009-01-01

    Title:    Discriminative ability of two different external anchors: improvement appears better than importance. Authors and affiliation: Henrik H. Lauridsen, DC, MSc, PhD*, Claus Manniche, MD, DMSc‡, Werner Vach, PhD §, Niels Grunnet-Nilsson DC, MD, PhD*, Jan Hartvigsen, DC, PhD*† * Clinical...... better discriminative abilities compared to the importance criterion. Consequently, we recommend using improvement and not importance as an anchor to determine the MIC....

  15. Fast Collision Attack on MD5

    NARCIS (Netherlands)

    Stevens, M.M.J.

    2006-01-01

    In this paper, we present an improved attack algorithm to find two-block collisions of the hash function MD5. The attack uses the same differential path of MD5 and the set of sufficient conditions that was presented by Wang et al. We present a new technique which allows us to deterministically fulfi

  16. Harvesting graphics power for MD simulations

    NARCIS (Netherlands)

    J.A. van Meel; A. Arnold; D. Frenkel; S.F. Portegies Zwart; R.G. Belleman

    2008-01-01

    We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a congruentia

  17. Advances in Delta-md measurements

    OpenAIRE

    Ronga, Frederic Jean

    2003-01-01

    We report the current status of Delta-md measurements at B-factories. The most recent world average is Delta-md = 0.502+-0.007 1/ps (1.4% accuracy). An estimate of the errors for 500 1/fb data is also given.

  18. The Hilbert space of conditional clauses

    CERN Document Server

    Francis, Charles

    2012-01-01

    Context. The well known problems of interpretation of quantum mechanics mean that physical law lacks physical basis. Aims. To abstract the formalism of quantum mechanics from assertions about the world with clear physical meaning. Methods. Kets are defined as conditional clauses referring to measurements in a formal language. It is seen that these clauses are elements of a Hilbert space, such that addition is logical disjunction, the dual space consists of consequent clauses, and the inner product is a set of statements in the subjunctive mood. The probability interpretation gives truth values for corresponding future tense statements when the initial state is prepared and the final state is to be measured. Results. The mathematical structure of quantum mechanics is formulated in terms of discrete measurement results at finite level of accuracy and does not depend on an assumption of a substantive, or background, spacetime continuum. A continuum of kets, |x> for x in R^3, is constructed from linear combinatio...

  19. 48 CFR 1316.601-70 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Time-and-Materials, Labor-Hour, and Letter Contracts 1316.601-70 Contract clauses. Insert clause 1352.216-77, Ceiling Price, in all time-and-materials contracts....

  20. CLAUSE AS THE TRANSLATION UNIT IN CHINESE TO ENGLISH TRANSLATION

    Institute of Scientific and Technical Information of China (English)

    向阳

    2001-01-01

    On the basis of Halliday' s theory, this paper makes it clear that clause as the translation unit is operational in Chinese to English translation and expounds the application of clause as the translation unit with some examples.

  1. Institute Cargo Clauses : Nova verzija 2009.

    OpenAIRE

    Lovrić, Ivana

    2012-01-01

    Institute Cargo Clauses, 2009. znače izmijenjene i dopunjene Institute Cargo Clauses iz 1982. Osnovni razlozi za reviziju prijašnjih uvjeta leže u pojavi novih rizika, potrebi da se uvjeti kargo osiguranja prilagode promjenama u suvremenom transportnom sustavu te jezično i terminološki osuvremene. Novi uvjeti donose niz rješenja koja znače modernizaciju u odnosu na rješenja Marine Insurance Acta iz 1906. Redaktori novih uvjeta vodili su računa i o tome da pojedine odredbe budu jasnije form...

  2. Trajanje osiguranja prema Institute Cargo Clauses (2009.)

    OpenAIRE

    Petrinović, Ranka; Lovrić, Ivana

    2012-01-01

    Institute Cargo Clauses iz 2009. zapravo su izmjene i dopune Institute Cargo Clauses iz 1982. Osnovni su razlozi za reviziju prijašnjih uvjeta u pojavi novih rizika, potrebi da se uvjeti kargo-osiguranja prilagode promjenama u suvremenome transportnom sustavu te jezično i terminološki osuvremene. Novi uvjeti donose više rješenja koja znače modernizaciju u usporedbi s onima u Marine Insurance Acta iz 1906., pa se prezentiraju kao klauzule za novo tisućljeće. Među bitnim promjenama koje donose ...

  3. 48 CFR 3447.7000 - Foreign travel clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Foreign travel clause... REGULATION CONTRACT MANAGEMENT TRANSPORTATION Foreign Travel 3447.7000 Foreign travel clause. The contracting officer shall insert the clause in 3452.247-70, Foreign Travel, in all solicitations and resultant...

  4. 48 CFR 41.501 - Solicitation provision and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... contract clauses. 41.501 Section 41.501 Federal Acquisition Regulations System FEDERAL ACQUISITION... Contract Clauses 41.501 Solicitation provision and contract clauses. (a) Because the terms and conditions... substantially the same as the provision at 52.241-1, Electric Service Territory Compliance Representation,...

  5. 48 CFR 1615.470-1 - Investment income clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Investment income clause. 1615.470-1 Section 1615.470-1 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT... CONTRACTING BY NEGOTIATION Contract Pricing 1615.470-1 Investment income clause. The clause set forth in...

  6. 78 FR 21343 - New Ski Area Water Rights Clause

    Science.gov (United States)

    2013-04-10

    ... Forest Service New Ski Area Water Rights Clause AGENCY: Forest Service, USDA. ACTION: Notice of meeting... rights clause for ski area permits issued by the Forest Service. There will be several stations at the... Service will consider in developing a new ski area water rights clause. There will be another...

  7. The influence of animacy on relative clause processing

    NARCIS (Netherlands)

    Mak, W.M.; Vonk, W.; Schriefers, H.J.

    2002-01-01

    In previous research it has been shown that subject relative clauses are easier to process than object relative clauses. Several theories have been proposed that explain the difference on the basis of different theoretical perspectives. However, previous research tested relative clauses only with an

  8. 48 CFR 52.241 - Utility Services Provisions and Clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Utility Services Provisions and Clauses. 52.241 Section 52.241 Federal Acquisition Regulations System FEDERAL ACQUISITION... Clauses 52.241 Utility Services Provisions and Clauses....

  9. 48 CFR 970.0370-2 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 970.0370... SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Improper Business Practices and Personal Conflicts of Interest 970.0370-2 Contract clause. (a) The contracting officer shall insert the clause at...

  10. 48 CFR 619.811-3 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract clauses. 619.811... PROGRAMS SMALL BUSINESS PROGRAMS Contracting with the Small Business Administration (The 8(a) Program) 619.811-3 Contract clauses. (d) The contracting officer shall insert the clause at FAR...

  11. 48 CFR 519.870-8 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract clauses. 519.870... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (The 8(a) Program) 519.870-8 Contract clauses. (a) Insert the following clauses in solicitations, contracts,...

  12. 48 CFR 1403.570-3 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 1403.570... IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Other Improper Business Practices 1403.570-3 Contract clause. CO's shall include the clause at 1452.203-70, Restriction on Endorsements, in...

  13. 48 CFR 203.570-3 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF DEFENSE GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Other Improper Business Practices 203.570-3 Contract clause. Use the clause at 252.203-7001, Prohibition on Persons... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clause....

  14. 48 CFR 1319.811-3 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1319.811... PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (the 8(a) Program) 1319.811-3 Contract clauses. (a) The contracting officer shall insert the clause 1352.219-70, Section...

  15. 48 CFR 970.0371-9 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 970.0371... SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Improper Business Practices and Personal Conflicts of Interest 970.0371-9 Contract clause. The contracting officer shall insert the clause at...

  16. 48 CFR 19.811-3 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clauses. 19.811-3... PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (the 8(a) Program) 19.811-3 Contract clauses. (a) The contracting officer shall insert the clause at 52.219-11, Special...

  17. 48 CFR 219.811-3 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clauses. 219.811..., DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (The 8(a) Program) 219.811-3 Contract clauses. (1) Use the clause at 252.219-7009, Section...

  18. 48 CFR 52.102 - Incorporating provisions and clauses.

    Science.gov (United States)

    2010-10-01

    ... REGULATION (CONTINUED) CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Instructions for Using... clause that can be accessed electronically by the offeror or prospective contractor may be incorporated... contracting officer includes in the solicitation and contract a statement that— (1) Identifies all...

  19. 48 CFR 2446.502-70 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clause. 2446.502-70 Section 2446.502-70 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT CONTRACT MANAGEMENT QUALITY ASSURANCE Acceptance 2446.502-70 Contract clause. The Contracting Officer shall insert the clause at...

  20. 48 CFR 229.402-70 - Additional clauses.

    Science.gov (United States)

    2010-10-01

    ... performance will be in Spain. (f) Use the clause at 252.229-7006, Value Added Tax Exclusion (United Kingdom.... (i) Use the clause at 252.229-7009, Relief from Customs Duty and Value Added Tax on Fuel (Passenger... SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS TAXES Contract Clauses...

  1. 48 CFR 970.5001-4 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... Safety Act 970.5001-4 Contract clause. When use of the clause at 48 CFR 52.250-1, Indemnification Under Public Law 85-804, Alternate 1 is appropriate, the contracting officer may substitute the words... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause....

  2. 48 CFR 333.215-70 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract clauses. 333.215... CONTRACTING REQUIREMENTS PROTESTS, DISPUTES, AND APPEALS Disputes and Appeals 333.215-70 Contract clauses. (a) The Contracting Officer shall insert the clause in 352.233-70, Choice of Law (Overseas),...

  3. 48 CFR 2832.1110 - Solicitation provision and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... contract clauses. 2832.1110 Section 2832.1110 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE General Contracting Requirements CONTRACT FINANCING Electronic Funds Transfer 2832.1110 Solicitation provision and contract clauses. When the clause at FAR 52.232-34, Payment by Electronic Funds...

  4. 48 CFR 232.1110 - Solicitation provision and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... contract clauses. 232.1110 Section 232.1110 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Electronic Funds Transfer 232.1110 Solicitation provision and contract clauses. Use the clause at 252.232-7009,...

  5. 48 CFR 32.1110 - Solicitation provision and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... contract clauses. 32.1110 Section 32.1110 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Electronic Funds Transfer 32.1110 Solicitation provision and contract clauses. (a) The contracting officer shall insert the clause at— (1)...

  6. Semantic Bias in the Acquisition of Relative Clauses in Japanese

    Science.gov (United States)

    Ozeki, Hiromi; Shirai, Yasuhiro

    2010-01-01

    This study analyzes the acquisition of relative clauses in Japanese to determine the semantic and functional characteristics of children's relative clauses in spontaneous speech. Longitudinal data from five Japanese children are analyzed and compared with English data (Diessel & Tomasello, 2000). The results show that the relative clauses produced…

  7. 48 CFR 1852.227-84 - Patent rights clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Patent rights clauses. 1852... 1852.227-84 Patent rights clauses. The contracting officer shall insert the following provision as prescribed in 1827.303-70(e): Patent Rights Clauses (DEC 1989) This solicitation contains the patent...

  8. Relative clauses in French children's narrative texts.

    Science.gov (United States)

    Jisa, H; Kern, S

    1998-10-01

    This study investigates the use of relative clauses in French children's narrative monologues. Narrative texts were collected from French-speaking monolinguals in four age groups (five, seven, ten years and adults). Twenty subjects from each group were asked to tell a story based on a picture book consisting of twenty-four images without text (Frog, Where are you?). Relative constructions were coded following the categories defined by Dasinger & Toupin (1994) into two main functional classes: general discourse and narrative functions. The results show that the use of relative clauses in general discourse functions precedes their use in more specific narrative functions. An analysis of textual connectivity (Berman & Slobin, 1994) in one episode reveals that children and adults differ in their choice of preferred structures. The results also show that children use fewer transitive predicates in relative clauses than do adults. Transitive verbs are essential for advancing the narrative plot (Hopper & Thompson, 1980). While subject relative clauses are acquired early and used frequently, the development of their multifunctional use in diverse narrative functions extends well beyond childhood.

  9. Head Position and Internally Headed Relative Clauses.

    Science.gov (United States)

    Basilico, David

    1996-01-01

    Examines "Head Movement" in internally headed relative clauses (IHRCs). The article shows that in some cases, head movement to an external position need not take place and demonstrates that this movement of the head to a sentence-internal position results from the quantificational nature of IHRCs and Diesing's mapping hypothesis (1990, 1992). (56…

  10. 48 CFR 811.204 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 811.204 Section 811.204 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS COMPETITION AND ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Using and Maintaining Requirements Documents 811.204...

  11. Retrenchment Clauses in Faculty Union Contracts.

    Science.gov (United States)

    Rhoades, Gary

    1993-01-01

    Examination of retrenchment clauses in the faculty union contracts at 42 colleges and universities focused on implications for tenure rights and the roles prescribed for faculty and administrators. Concepts of financial exigency and shared governance are highlighted. Contracts were found to provide faculty with a limited and reactive role during…

  12. 48 CFR 927.303 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... is a domestic small business or nonprofit organization as defined at (FAR) 48 CFR 27.301, except... (but see (FAR) 48 CFR 27.304-3 regarding contracts for construction work or architect-engineer services... use the clause at (FAR) 48 CFR 52.227-12 except in situations where patent counsel grants a...

  13. 48 CFR 503.1004 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract clauses. 503.1004 Section 503.1004 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Contractor Code of Business Ethics and Conduct...

  14. 48 CFR 1403.1004 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 1403.1004 Section 1403.1004 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Contractor Code of Business Ethics and Conduct...

  15. 48 CFR 923.7003 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 923.7003 Section 923.7003 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS..., the contract or subcontract must include language to specify the extent of applicability of...

  16. The occupational health of Santa Claus

    OpenAIRE

    Straube, Sebastian; Fan, Xiangning

    2015-01-01

    Previous publications in the field of Santa studies have not focused on health and safety issues arising from Santa’s workplace activities. However, it should be acknowledged that unique occupational hazards exist for Santa Claus. Major occupational health issues affecting Santa are discussed, along with suggestions for future research directions.

  17. 48 CFR 44.204 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... contract, awarded on the basis of adequate price competition or whose prices are set by law or regulation... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clauses. 44.204 Section 44.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT...

  18. 48 CFR 1808.870 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clause. 1808.870 Section 1808.870 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION COMPETITION AND ACQUISITION PLANNING REQUIRED SOURCES OF SUPPLIES AND SERVICES Acquisition of Printing and Related Supplies 1808.870 Contract...

  19. 48 CFR 22.202 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clause. 22.202 Section 22.202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC... employment of convict labor; (b) The supplies or services are to be purchased from Federal Prison...

  20. Santa Claus:The True Story

    Institute of Scientific and Technical Information of China (English)

    袁波

    2004-01-01

    @@ (1) I remember my first Christmas party with Grandma.I was just a kid.Iremeber Iwas running across town on my bike to Grandma's on the day my big sister said:"There's no Santa Claus. Even a fool knows that!"

  1. 48 CFR 13.302-5 - Clauses.

    Science.gov (United States)

    2010-10-01

    ... requirement unless the existing requirement is deleted. Also, do not delete a paragraph without providing for... cannot be set aside for small business concerns and trade agreements apply (see Subpart 25.4), substitute the clause at FAR 52.225-3, Buy American Act—Free Trade Agreements—Israeli Trade Act, used...

  2. 48 CFR 46.710 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... and Equipment under Performance Specifications or Design Criteria, in solicitations and contracts when performance specifications or design are of major importance; a fixed-price supply, service, or research and... clause at 52.246-19, Warranty of Systems and Equipment under Performance Specifications or...

  3. 48 CFR 1809.670 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clause. 1809.670 Section 1809.670 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION... than one legal entity, such as a joint venture....

  4. Obituary of Philip H. Cooper, MD.

    Science.gov (United States)

    Patterson, James W; Wick, Mark R; Mills, Stacey E

    2015-08-01

    Dermatopathology lost a giant in the field with the death of Philip H. Cooper, MD, on Friday, January 30, 2015. The following obituary represents a celebration of his life and his contributions to our field.

  5. PODI AND ODI IN CLAUSE CONSTRUCTION OF KEMAK

    Directory of Open Access Journals (Sweden)

    I Wayan Budiarta

    2013-03-01

    Full Text Available This article reveals podi and odi in clause construction of Kemak. Specifically, this article is aimed at finding out in what construction  podi and odi appear. Moreover, this article is also aimed at finding out the function of podi and odi in the clause construction of Kemak. Before exploring podi and odi in clause construction, the first discussion will examine the morphology of the verb of Kemak to find out how the verbs are formed in Kemak as they have the main role to fill the predicate. The discussion continues to examine the clause with nonverbal (verbless and verbal predicate. Clause with nonvebral (verbless predicate will begin the discussion on clause construction in Kemak. Then, the discussion goes to clause with verbal predicate. The clause with verbal predicate includes intransitive and transtive. The disscussion of transitive clause covers monotransitive and  ditransitive clause. The  study on transitive clause is related to the presence of podi and odi in the construction.The result shows that all verbs are basic verbs. Verbs in Kemak are morphologically unmarked (no affixes and there is no agreement between the verb and its arguments. The clause with nonverbal predicate in Kemak is filled by  noun, adjective, numeral, and prepositional phrase. Clause with nonverbal predicate requires one argument  functioning as grammatical subject. As cluase with nonverbal predicate, intransitive clause in Kemak also requires one argument  functioning as grammatical subject. Meanwhile, monotransitive clause requires two arguments, preverbal and postverbal argument. Ditranstive clause requires three arguments, one preverbal and two postverbal argument. Moreover, it was found that  podi appears in ditransitive clause (applicative/benefactive construction. Podi has the function to increase the verb valence from monotransitive into ditransitive. Meanwhile, odi appears in monotransitive clause  The presence of odi in monotrasitive is as the

  6. Multi-Dimensional Games (MD-Games)

    OpenAIRE

    Ruiz Estrada, M.A.

    2009-01-01

    This paper introduces the concept of Multi-Dimensional games (MD-games) based on the application of an alternative mathematical and graphical modeling approach to study the game theory from a multi-dimensional perspective. In fact, the MD-Games request the application of the mega-space coordinate system to visualize a large number of games, players, strategies and pay-offs functions into the same graphical space.

  7. An Efficient One-pot Synthesis of β-Amino/β-Acetamido Car-bonyl Compounds via ZrCl4-catalyzed Mannich-type Reaction

    Institute of Scientific and Technical Information of China (English)

    SANJEEVA REDDY,Cherkupally; PURNACHANDRA REDDY,Gurrala

    2008-01-01

    Zirconium(IV) chloride catalyzed efficient one-pot synthesis of β-amino/β-acetamido carbonyl compounds at room temperature is described. In the presence of ZrCl4, the three-component Mannich-type reaction via a variety of in situ generated aldimines, with various ketones, aromatic aldehydes and aromatic amines in ethanol, led to the formation of β-amino carbonyl compounds and the four-component Mannich-type reaction of aromatic aldehydes with various ketones, acetonitrile and acetyl chloride resulted in the corresponding β-acetamido carbonyl com-pounds in high to excellent yields. This methodology has also been applied towards the synthesis of dimeric β-amino/β-acetamido carbonyl compounds.

  8. Direct carbon-carbon bond formation via reductive soft enolization: a syn-selective Mannich addition of α-iodo thioesters.

    Science.gov (United States)

    Truong, Ngoc; Sauer, Scott J; Seraphin-Hatcher, Cyndie; Coltart, Don M

    2016-08-16

    The β-amino carboxylic acid moiety is a key feature of numerous important biologically active compounds. We describe a syn-selective direct Mannich addition reaction that uses α-iodo thioesters and sulfonyl imines and produces β-amino thioesters. Enolate formation is achieved by reductive soft enolization. The products of the reaction provide straightforward access to biologically important β-lactams through a variety of known reactions. PMID:27492274

  9. MD5算法的分析和改进%Analysis and Improvement of .MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    么丽颖

    2011-01-01

    首先研究了MD5算法,并总结了MD5算法的特点及性能,在研究MD5算法的基础之上,提出了MD5改进加密算法.最后,对MD5算法与MD5改进算法对应于相关数据、性能进行了比较.%At first , MD5 algorithm is researched, and the characteristic and capability of the MD5 are summaried in the paper. The improved MD5 algorithm is put forward based on the research of the MDS. At last, the contrast between MD5 algorithm and the improved MD5 algorithm in related datum and capability are put forward.

  10. New Message Differences for Collision Attacks on MD4 and MD5

    Science.gov (United States)

    Sasaki, Yu; Wang, Lei; Kunihiro, Noboru; Ohta, Kazuo

    In 2005, collision resistance of several hash functions was broken by Wang et al. The strategy of determining message differences is the most important part of collision attacks against hash functions. So far, many researchers have tried to analyze Wang et al.'s method and proposed improved collision attacks. Although several researches proposed improved attacks, all improved results so far were based on the same message differences proposed by Wang et al. In this paper, we propose new message differences for collision attacks on MD4 and MD5. Our message differences of MD4 can generate a collision with complexity of less than two MD4 computations, which is faster than the original Wang et al.'s attack, and moreover, than the all previous attacks. This is the first result that improves the complexity of collision attack by using different message differences from Wang et al.'s. Regarding MD5, so far, no other message difference from Wang et al.'s is known. Therefore, study for constructing method of other message differences on MD5 should be interesting. Our message differences of MD5 generates a collision with complexity of 242 MD5 computations, which is slower than the latest best attack. However, since our attack needs only 1 bit difference, it has some advantages in terms of message freedom of collision messages.

  11. Improving SAT Solvers via Blocked Clause Decomposition

    OpenAIRE

    Chen, Jingchao

    2016-01-01

    The decision variable selection policy used by the most competitive CDCL (Conflict-Driven Clause Learning) SAT solvers is either VSIDS (Variable State Independent Decaying Sum) or its variants such as exponential version EVSIDS. The common characteristic of VSIDS and its variants is to make use of statistical information in the solving process, but ignore structure information of the problem. For this reason, this paper modifies the decision variable selection policy, and presents a SAT solvi...

  12. Fast Collision Attack on MD5

    OpenAIRE

    Stevens, Marc

    2006-01-01

    In this paper, we present an improved attack algorithm to find two-block collisions of the hash function MD5. The attack uses the same differential path of MD5 and the set of sufficient conditions that was presented by Wang et al. We present a new technique which allows us to deterministically fulfill restrictions to properly rotate the differentials in the first round. We will present a new algorithm to find the first block and we will use an algorithm of Klima to find the second block. To o...

  13. Novel aminonaphthoquinone mannich bases derived from lawsone and their copper(II) complexes: synthesis, characterization and antibacterial activity

    Energy Technology Data Exchange (ETDEWEB)

    Neves, Amanda P.; Barbosa, Claudia C.; Greco, Sandro J.; Vargas, Maria D. [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Inst. de Quimica; Visentin, Lorenzo C. [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Inst. de Quimica; Pinheiro, Carlos B. [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Dept. de Fisica; Mangrich, Antonio S. [Universidade Federal do Parana (UFPR), Curitiba, PR (Brazil). Centro Politecnico. Dept. de Quimica; Barbosa, Jussara P.; Costa, Gisela L. da [Instituto Oswaldo Cruz, Rio de Janeiro, RJ (Brazil)

    2009-07-01

    A series of novel Mannich bases (HL1-HL13) derived from 2-hydroxy-1,4-naphthoquinone (lawsone), substituted benzaldehydes [C{sub 6}H{sub 2}R{sup 1}R{sup 2}R{sup 3}C(O)H] and various primary amines (NH{sub 2}R{sup 4}, R{sup 4} = n-butyl, benzyl, allyl, 2-furfuryl), and their Cu{sup 2+} complexes, [Cu(L1){sub 2}]-[Cu(L13){sub 2}], have been synthesized and fully characterized by analytical and spectroscopic methods. The structures of complexes 1 (R{sup 1} R{sup 2} = R{sup 3} = H; R{sup 4} = Bu), 2 (R{sup 1} = R{sup 3} = H; R{sup 2} = NO{sub 2}; R{sup 4}= Bu) and 7 (R{sup 1} OH; R{sup 2} = R{sup 3} = H; R{sup 4}= Bu) were determined by single crystal X-ray diffraction studies. All complexes crystallize in centrosymmetric space groups, with a copper atom in the inversion centre. Two L. coordinate through the naphthalen-2-olate oxygen and secondary amine-N atoms, forming six membered chelate rings around the copper atom in a trans-N{sub 2}O{sub 2} environment; spectroscopic data confirm that the other complexes exhibit similar molecular arrangement. The antimicrobial activity of all compounds has been tested on seven different strains of bacteria: Bacillus cereus, Bacillus subtilis, Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae, Pseudomonas aeruginosa and Staphylococcus aureus. In general, Mannich bases were more active than complexes, HL11 (R{sup 1} = OH; R{sup 2} =H; R{sup 3} = Me; R{sup 4}= Bn) and HL13 (R{sup 1} = OH; R{sup 2} = H; R{sup 3} = Br; R{sup 4}= Bn) being the most potent inhibitors. The MIC for the most active compound HL11 against S. Coli was 20 {mu}mol L{sup -1} (8 {mu}g mL{sup -1}), better than Chloramphenicol (90 {mu}mol L{sup -1}) and well below most values reported for other naphthoquinones. (author)

  14. What undertakings are protected under Umbrella Clauses of BITs.

    OpenAIRE

    Khasanov, Jamshid

    2015-01-01

    The thesis is discusses what is the scope of Umbrella Clauses. State undertakings must satisfy the condition of being investment. That is the first requirement of applicability of investment regime to state undertakings. Despite state undertakings was seen as wide concept (by some tribunals) the language of the clause and prevailing view support undertakings must be limited to contractual undertakings (in practice some viewed that Umbrella Clause can be extended to municipal law obligations) ...

  15. 12 CFR 34.5 - Due-on-sale clauses.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Due-on-sale clauses. 34.5 Section 34.5 Banks... General § 34.5 Due-on-sale clauses. A national bank may make or acquire a loan or interest therein, secured by a lien on real property, that includes a due-on-sale clause. Except as set forth in 12...

  16. Two types of Temporal when clauses in Hausa

    OpenAIRE

    Abdoulaye, Mahamane L.

    2009-01-01

    23; International audience; Hausa has simple temporal clauses, introduced by the conjunction dà ‘when', that many researchers derive from temporal relative clauses introduced by lookàcin dà ‘time that', through the deletion of the pseudo head word lookàcii ‘time'. This paper shows that this analysis, however natural it may appear, is inadequate. Indeed, the two temporal clauses have different uses, which would not be surprising if simple temporal clauses are derivationally independent from te...

  17. 78 FR 2707 - Maryland Disaster # MD-00026

    Science.gov (United States)

    2013-01-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Maryland Disaster MD-00026 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... Deadline Date: 10/02/2013. ADDRESSES: Submit completed loan applications to: U.S. Small...

  18. 37 CFR 401.13 - Administration of patent rights clauses.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Administration of patent rights clauses. 401.13 Section 401.13 Patents, Trademarks, and Copyrights ASSISTANT SECRETARY FOR... patent rights clauses. (a) In the event a subject invention is made under funding agreements of more...

  19. 48 CFR 2437.110 - Solicitation provisions and contract clauses.

    Science.gov (United States)

    2010-10-01

    ...) The Contracting Officer shall insert the clause at 48 CFR 2452.237-73, Conduct of Work and Technical... part 12. (e) The Contracting Officer shall insert the clause at 48 CFR 2452.237-75, Clearance of..., Observance of Legal Holidays and Administrative Leave, in all solicitations and contracts where...

  20. 48 CFR 709.507-2 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... solicitation or resulting contract or both include a provision in accordance with (48 CFR) FAR 9.507-1, or a clause in accordance with (48 CFR) FAR 9.507-2, establishing a restraint on the contractor's eligibility... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause....

  1. 48 CFR 538.7004 - Solicitation provisions and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... and contract clauses. 538.7004 Section 538.7004 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION SPECIAL CATEGORIES OF CONTRACTING FEDERAL SUPPLY SCHEDULE CONTRACTING Cooperative... insert the clause at 552.238-79, Use of Federal Supply Schedule Contracts by Certain...

  2. 48 CFR 3427.472 - Advertising of awards clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Advertising of awards... Copyrights 3427.472 Advertising of awards clause. The contracting officer shall insert the clause in 3452.227-72, Advertising of Awards, in all solicitations and contracts other than purchase orders....

  3. 48 CFR 1019.811-3 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1019.811... PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (The 8(a) Program) 1019.811-3 Contract clauses. (d)(3) Insert theclause at DTAR 1052.219-18, Notification of...

  4. 48 CFR 1503.500-72 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Contractor Responsibility To Avoid Improper Business Practices 1503.500-72 Contract clause. As required by EPAAR 1503.500-71(b), the contracting... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clause....

  5. 48 CFR 970.5201 - Text of provisions and clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Text of provisions and clauses. 970.5201 Section 970.5201 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY... for Management and Operating Contracts 970.5201 Text of provisions and clauses....

  6. On the phrasing properties of Hindi relative clauses

    NARCIS (Netherlands)

    Gryllia, S.; Féry, C.; Kügler, F.; Pandey, P.; The, Scottish Consortium for ICPhS 2015

    2015-01-01

    This paper presents results from a production experiment in Hindi, showing that differences in attachment site of object relative clauses result in prosodic differences when the antecedent of the relative clause (RC) is part of a complex NP with the structure N1 of N2. In particular, based on durati

  7. 48 CFR 3032.1110 - Solicitation provision and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... FINANCING Electronic Funds Transfer 3032.1110 Solicitation provision and contract clauses. (a)(1) Contracting officer shall insert FAR 48 CFR 52.232-33, Payment by Electronic Funds Transfer—Central Contractor... contract clauses. 3032.1110 Section 3032.1110 Federal Acquisition Regulations System DEPARTMENT OF...

  8. The Production of Complement Clauses in Children with Language Impairment

    Science.gov (United States)

    Steel, Gillian; Rose, Miranda; Eadie, Patricia

    2016-01-01

    Purpose: The purpose of this research was to provide a comprehensive description of complement-clause production in children with language impairment. Complement clauses were examined with respect to types of complement structure produced, verb use, and both semantic and syntactic accuracy. Method: A group of 17 children with language impairment…

  9. 41 CFR 60-250.5 - Equal opportunity clause.

    Science.gov (United States)

    2010-07-01

    ... contractor's organization, and positions lasting three days or less. This term includes full-time employment, temporary employment of more than three days' duration, and part-time employment. ii. Executive and top... opportunity clause in the contract. It is not necessary that the equal opportunity clause be quoted...

  10. 41 CFR 60-300.5 - Equal opportunity clause.

    Science.gov (United States)

    2010-07-01

    ... be filled from within the contractor's organization, and positions lasting three days or less. This term includes full-time employment, temporary employment of more than three days' duration, and part... opportunity clause in the contract. It is not necessary that the equal opportunity clause be quoted...

  11. 32 CFR 643.55 - Mandatory revocation clause in lease.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Mandatory revocation clause in lease. 643.55... PROPERTY REAL ESTATE Leases § 643.55 Mandatory revocation clause in lease. Each lease will contain a provision permitting the SA to revoke the lease at any time, unless it is determined that the omission...

  12. The Elicited Production of Korean Relative Clauses by Heritage Speakers

    Science.gov (United States)

    Lee-Ellis, Sunyoung

    2011-01-01

    In response to new theoretical claims and inconclusive empirical findings regarding relative clauses in East Asian languages, this study examined the factors relevant to relative clause production by Korean heritage speakers. Gap position (subject vs. object), animacy (plus or minus animate), and the topicality of head nouns (plus or minus…

  13. Direct NOE simulation from long MD trajectories

    Science.gov (United States)

    Chalmers, G.; Glushka, J. N.; Foley, B. L.; Woods, R. J.; Prestegard, J. H.

    2016-04-01

    A software package, MD2NOE, is presented which calculates Nuclear Overhauser Effect (NOE) build-up curves directly from molecular dynamics (MD) trajectories. It differs from traditional approaches in that it calculates correlation functions directly from the trajectory instead of extracting inverse sixth power distance terms as an intermediate step in calculating NOEs. This is particularly important for molecules that sample conformational states on a timescale similar to molecular reorientation. The package is tested on sucrose and results are shown to differ in small but significant ways from those calculated using an inverse sixth power assumption. Results are also compared to experiment and found to be in reasonable agreement despite an expected underestimation of water viscosity by the water model selected.

  14. MD on UFOs at MKIs and MKQs

    CERN Document Server

    Baer, T; Bartmann, W; Bracco, C; Carlier, E; Dehning, B; Garrel, N; Goddard, B; Jackson, S; Jimenez, M; Kain, V; Mertens, V; Misiowiec, M; Nordt, A; Papotti, G; Uythoven, J; Wenninger, J; Zerlauth, M; Zamantzas, C; Zimmermann, F

    2012-01-01

    UFOs ("Unidentified Falling Objects") are expected to be one of the major known performance limitation of the LHC. In this MD, the production mechanism and the dynamics of UFOs at the injection kicker magnets (MKIs) and the tune kicker magnets (MKQs) were studied. This was done by pulsing the MKIs and MKQs on a gap in the partly filled machine. During the MD, in total 58 UFO-type beam loss patterns were observed directly after pulsing the MKIs. None were observed after pulsing the MKQs, which provides important input for possible mitigation strategies. The temporal and spatial distribution of the UFO events could be determined by using a dedicated BLM Study Buffer, the implications for the UFO dynamics are discussed.

  15. MD5的Keygenme分析

    Institute of Scientific and Technical Information of China (English)

    Firebig

    2006-01-01

    闲来无事,抓出个不知何时下的Keygenme练练手,分析后可知.这个Keygenme有2张数据表,由注册名经MD5运算后进行查表,得出2个DWORD数据.然后再由注册码经过一个可逆循环得出2个DWORD数据.最后对比是否正确。(MD5的具体介绍黑防6期有说明)

  16. Integrative Medicine Program- MD Anderson Cancer Center

    OpenAIRE

    Lee, Richard T.

    2012-01-01

    The Integrative Medicine Program at MD Anderson Cancer Center was first established in 1998.  Our mission is to empower patients with cancer and their families to become active partners in their own physical, psycho-spiritual, and social health through personalized education and evidenced-based clinical care to optimize health, quality of life, and clinical outcomes across the cancer continuum.  The program consists of three main components: clinical care, research, and education.  The Integr...

  17. Classical MD calculations with parallel computers

    Energy Technology Data Exchange (ETDEWEB)

    Matsumoto, Mitsuhiro [Nagoya Univ. (Japan)

    1998-03-01

    We have developed parallel computation codes for a classical molecular dynamics (MD) method. In order to use them on work station clusters as well as parallel super computers, we use MPI (message passing interface) library for distributed-memory type computers. Two algorithms are compared: (1) particle parallelism technique: easy to install, effective for rather small number of processors. (2) region parallelism technique: take some time to install, effective even for many nodes. (J.P.N.)

  18. An efficient synthesis of β-amino ketone compounds through one-pot three-component Mannich-type reactions using bismuth nitrate as catalyst

    Directory of Open Access Journals (Sweden)

    S. Sheik Mansoor

    2015-07-01

    Full Text Available Three components one-pot Mannich reaction of aromatic ketone, aromatic aldehyde and aromatic amines has been efficiently catalyzed by recyclable bismuth nitrate (Bi(NO33, BN at ambient temperature to give various β-amino carbonyl compounds in high yields. This method has advantages of mild condition, no environmental pollution, and simple work-up procedures. Most importantly, β-amino carbonyl compounds with ortho-substituted aromatic amines are obtained in acceptable to moderate yields by this methodology.

  19. Synthesis and Antimicrobial Activity of Schiff’s and N-Mannich Bases of Isatin and Its Derivatives with 4-Amino-N-Carbamimidoyl Benzene Sulfonamide

    Directory of Open Access Journals (Sweden)

    U. K. Singh

    2010-04-01

    Full Text Available Isatin and substituted Isatin were reacted with 4-amino-N-carbamimidoyl benzene sulfonamide to form a series of Schiff’s bases. The Mannich bases of these compounds were synthesized by reacting them with formaldehyde and secondary amine (piperidine. All the compounds were characterized by means of their IR, 1H NMR spectroscopic data and elemental analysis. The antimicrobial activity of the synthesized compounds was evaluated by tube dilution method. The synthesized compounds showed better antibacterial activity than the reference drugs.

  20. Claus recycle with double combustion process

    Energy Technology Data Exchange (ETDEWEB)

    El-Bishtawi, Ribhi; Haimour, No' man [University of Jordan, Amman 11942 (Jordan)

    2004-12-15

    A new modification is developed on conventional Claus process to increase the overall sulfur recovery as well as to decrease the costs. The modification combines both oxygen enrichment and recycling. The process is simulated and studied for various N{sub 2}/O{sub 2} ratios with and without using SURE double combustion technique. The predictions show that using pure oxygen in combustion, condensing water vapor in a condenser following the first sulfur condenser and recycling the effluent gas to combine it with fresh acid gas feed leads to large savings in the production cost and to a clean environment. However, it leads to a high adiabatic flame temperature which exceeds the maximum allowable temperature of the furnace material of construction as well as its refractory. To avoid these effects, it is necessary to use SURE double combustion technique. The oxygen flow rate to the first combustion stage should not exceed 78% O{sub 2}.

  1. Natural syntax : English interrogative main clauses

    Directory of Open Access Journals (Sweden)

    Janez Oresnik

    2007-12-01

    Full Text Available Natural Syntax is a developing deductive theory, a branch of Naturalness Theory. The naturalnessjudgements are couched in naturalness scales, whichfollow from the basic parameters (or «axioms» listed at the beginning of the paper. The predictions of the theory are calculated in deductions, whose chief components are apair of naturalness scales and the rules governing the alignment of corresponding naturalness values. Parallel and chiastic alignments are distinguished, in complementary distribution. Chiastic alignment is mandatory in deductions limited to unnatural environments. The paper deals with English interrogative main clauses. Within these, only the interrogatives containing wh-words exclusively insitu constitute an extremely unnatural environment and require chiastic alignment. Otherwiseparallel alignment is used. Earlier publications on Natural Syntax: Kavcic 2005a,b, Oresnik 1999, 2000a,b, 200la-f   2002, 2003a-c, 2002/03, 2004. This list cites only works written in English.

  2. Computer Security: a plea to Santa Claus

    CERN Document Server

    Stefan Lueders, Computer Security Team

    2015-01-01

    Running pirated software or illegal licences, using cracking tools to bypass software activation measures, sharing music and films – these are problems that academic environments unfortunately have to deal with. All violate the copyright of the software/music/film owners, and copyright owners are not Santa Claus...    CERN, like other research organisations and universities, regularly receives allegations from external companies complaining about laptops or PCs running illegal software or sharing their films, videos or music with peers – and thus violating copyright.  Usually, we then contact the owners of the corresponding devices in order to understand whether these allegations are true. Very often such allegations boil down to a laptop whose owner replies “I confirm that a torrent client was left up and running on my device by mistake” or “This is a file that is stored on my personal hard disk.” As if those allegatio...

  3. 48 CFR 1436.270-3 - Part II-Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Part II-Contract clauses... Construction 1436.270-3 Part II—Contract clauses. For Section I, Contract clause, include any clauses required by law or by the FAR (including subpart 36.5), the DIAR (including subpart 1436.5), and...

  4. Punctuation and Intonation Effects on Clause and Sentence Wrap-Up: Evidence from Eye Movements

    Science.gov (United States)

    Hirotani, Masako; Frazier, Lyn; Rayner, Keith

    2006-01-01

    Three eye movement studies examined the role of punctuation in reading. In Experiment 1, although a comma at the end of a clause facilitated overall reading times for the sentence, first pass times were longer at the end of comma-marked clauses than clauses without a comma (or the same material in clause medial position). The data supported the…

  5. ProtoMD: A prototyping toolkit for multiscale molecular dynamics

    Science.gov (United States)

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2016-05-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates 'GROMACS wrapper' to initiate MD simulations, and 'MDAnalysis' to analyze and manipulate trajectory files. It facilitates experimentation with a spectrum of coarse-grained variables, prototyping rare events (such as chemical reactions), or simulating nanocharacterization experiments such as terahertz spectroscopy, AFM, nanopore, and time-of-flight mass spectroscopy. ProtoMD is written in python and is freely available under the GNU General Public License from github.com/CTCNano/proto_md.

  6. Integrative Medicine Program- MD Anderson Cancer Center

    Directory of Open Access Journals (Sweden)

    Richard T Lee

    2012-06-01

    Full Text Available The Integrative Medicine Program at MD Anderson Cancer Center was first established in 1998.  Our mission is to empower patients with cancer and their families to become active partners in their own physical, psycho-spiritual, and social health through personalized education and evidenced-based clinical care to optimize health, quality of life, and clinical outcomes across the cancer continuum.  The program consists of three main components: clinical care, research, and education.  The Integrative Medicine Center provides clinical services to patients through individual and group programs.  The clinical philosophy of the center is to work collaboratively with the oncology teams to build comprehensive and integrative care plans that are personalized, evidence-based, and safe with the goal of improving clinical outcomes.  The individual services comprise of integrative oncology consultation, acupuncture, meditation, music therapy, nutrition, and oncology massage.  The center also provides a variety of group programs including meditation, yoga, tai chi, cooking classes and others.  Over the past 13 years, over 70,000 patients and families have participated in services and programs offered by the center.  The research portfolio focuses on three main areas: mind-body interventions, acupuncture, and meditation.  This lecture will focus on providing an overview of the Integrative Medicine Program at MD Anderson with a focus on the clinical services provided.  Participants will learn about the integrative clinical model and how this is applied to the care of cancer patients at MD Anderson Cancer Center.  Current and future research topics will be discussed as well as patient cases.

  7. V2 word order in subordinate clauses in spoken Danish

    DEFF Research Database (Denmark)

    Jensen, Torben Juel; Christensen, Tanya Karoli

    Danish grammatical tradition has it that V2 and V3 word order are signals of the syntactic difference between main and subordinate clauses. However, several studies have shown that both word orders appear in both clause types (Heltoft 2005, Christensen 2007, Jensen forthc.). Though V2 and V3...... studies of two age cohorts of speakers in Copenhagen, recorded in the 1980s and again in 2005-07, and on recent recordings with two age cohorts of speakers from the western part of Jutland. This makes it possible to study variation and change with respect to word order in subordinate clauses in both real...

  8. Formal verification of communication protocols using quantized Horn clauses

    Science.gov (United States)

    Balu, Radhakrishnan

    2016-05-01

    The stochastic nature of quantum communication protocols naturally lends itself for expression via probabilistic logic languages. In this work we describe quantized computation using Horn clauses and base the semantics on quantum probability. Turing computable Horn clauses are very convenient to work with and the formalism can be extended to general form of first order languages. Towards this end we build a Hilbert space of H-interpretations and a corresponding non commutative von Neumann algebra of bounded linear operators. We demonstrate the expressive power of the language by casting quantum communication protocols as Horn clauses.

  9. First principles and DFT supported investigations on vibrational spectra and electronic structure of 2-((phenylamino)methyl)isoindoline-1,3-dione - An antioxidant active Mannich base

    Science.gov (United States)

    Boobalan, Maria susai; Amaladasan, M.; Ramalingam, S.; Tamilvendan, D.; Venkatesa Prabhu, G.; Bououdina, M.

    2015-02-01

    The 2-((phenylamino)methyl)isoindoline-1,3-dione (PID) is a synthesized Mannich base which has significant antioxidant activity and biological importance. Quantum mechanical calculations on energy, geometry and vibrational wavenumber of PID were computed using ab initio HF and density functional theory (DFT/B3LYP) methods with 6-31+G/6-311++G(d,p) basis sets. Optimized geometrical parameters obtained by HF and DFT calculations were indicatively agreement with experimental crystal geometry. The experimental FT-Raman and FT-IR spectra of PID has been recorded and analyzed by comparing with simulated spectra. The 1H and 13C NMR spectra of title molecule records the chemical shift resulted from shielding and deshielding effects. Natural bond orbital (NBO) analysis has been carried out to calculate various intramolecular interactions that are accountable for the stabilization of this Mannich base. The predicted HOMO-LUMO gap offers interesting information on intramolecular charge transfer and reactivity of the molecular system. Molecular electrostatic potential (MEP) imprint visualize the reactive sites in PID, which is also supported by Mulliken, ESP, Hirshfeld and NBO charges. Thermodynamic properties of PID at various temperatures have been calculated at B3LYP/6-311++G(d,p) in gas phase and the correlations between standard entropies (S), internal energy (E or U) and standard heat capacity (C) with different temperatures.

  10. MD Test of a Ballistic Optics

    CERN Document Server

    Garcia-Tabares Valdivieso, Ana; Salvachua Ferrando, Belen Maria; Skowronski, Piotr Krzysztof; Solfaroli Camillocci, Matteo; Tomas Garcia, Rogelio; Wenninger, Jorg; Coello De Portugal - Martinez Vazquez, Jaime Maria; CERN. Geneva. ATS Department

    2016-01-01

    The ballistic optics is designed to improve the understanding of optical errors and BPM systematic effects in the critical triplet region. The particularity of that optics is that the triplet is switched off, effectively transforming the triplets on both sides of IR1 and IR5 into drift spaces. Advantage can be taken from that fact to localize better errors in the Q4-Q5-triplet region. During this MD this new optics was tested for the first time at injection with beam 2.

  11. 76 FR 1993 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Science.gov (United States)

    2011-01-12

    ... (75 FR 34661). That NPRM proposed to require installing fuel level float and pressure switch in-line... 12866, (2) Is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034... Maintenance Manual (AMM) defueling procedure MD80 AMM 12-13-00. The correct reference is Boeing MD80 AMM...

  12. 48 CFR 1327.305 - Administration of patent rights clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administration of patent... GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights Under Government Contracts 1327.305 Administration of patent rights clauses....

  13. 48 CFR 27.305 - Administration of patent rights clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Administration of patent... REGULATION GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights under Government Contracts 27.305 Administration of patent rights clauses....

  14. 48 CFR 2427.305 - Administration of patent rights clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Administration of patent... AND URBAN DEVELOPMENT SOCIOECONOMIC PROGRAMS PATENTS, DATA, AND COPYRIGHTS Patent Rights Under Government Contracts 2427.305 Administration of patent rights clauses....

  15. 48 CFR 1227.305 - Administration of patent rights clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administration of patent... TRANSPORTATION GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights Under Government Contracts 1227.305 Administration of patent rights clauses....

  16. 48 CFR 339.7103 - Solicitation and contract clause.

    Science.gov (United States)

    2010-10-01

    ... clause. 339.7103 Section 339.7103 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES SPECIAL CATEGORIES OF CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Information Security Management...-72, Security Requirements for Federal Information Technology Resources, in solicitations...

  17. A U-Shaped Relative Clause Attachment Preference in Japanese.

    Science.gov (United States)

    Miyamoto, Edson T.; Gibson, Edward; Pearlmutter, Neal J.; Aikawa, Takako; Miyagawa, Shigeru

    1999-01-01

    Presents results from a self-paced reading experiment in Japanese investigating attachment preferences for relative clauses to three ensuing potential nominal heads. Results are discussed in light of two types of parsing models. (Author/VWL)

  18. 48 CFR 570.604 - Deviations to provisions and clauses.

    Science.gov (United States)

    2010-10-01

    ... Contingent Fees, FAR 52.215-2, Audit and Records—Negotiation). The authorizing statue must allow for a waiver. (c) Certain clauses required by non-GSA regulations require approval of the issuing agency before...

  19. From Pauses to Clauses: Prosody Facilitates Learning of Syntactic Constituency

    OpenAIRE

    Hawthorne, Kara; Gerken, LouAnn

    2014-01-01

    Learning to parse the speech stream into syntactic constituents is a crucial prerequisite to adult-like sentence comprehension, and prosody is one source of information that could be used for this task. To test the role of prosody in facilitating constituent learning, 19-month-olds were familiarized with non-word sentences with 1-clause (ABCDEF) or 2-clause (ABC, DEF) prosody and were then tested on sentences that represent a grammatical (DEF, ABC) or ungrammatical (EFA, BCD) 'movement' of th...

  20. Compiling HPSG type constraints into definite clause programs

    CERN Document Server

    Götz, T; Goetz, Thilo; Meurers, Walt Detmar

    1995-01-01

    We present a new approach to HPSG processing: compiling HPSG grammars expressed as type constraints into definite clause programs. This provides a clear and computationally useful correspondence between linguistic theories and their implementation. The compiler performs off-line constraint inheritance and code optimization. As a result, we are able to efficiently process with HPSG grammars without having to hand-translate them into definite clause or phrase structure based systems.

  1. ProtoMD: A prototyping toolkit for multiscale molecular dynamics

    Science.gov (United States)

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2016-05-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates 'GROMACS wrapper' to initiate MD simulations, and 'MDAnalysis' to analyze and manipulate trajectory files. It facilitates experimentation with a spectrum of coarse-grained variables, prototyping rare events (such as chemical reactions), or simulating nanocharacterization experiments such as terahertz spectroscopy, AFM, nanopore, and time-of-flight mass spectroscopy. ProtoMD is written in python and is freely available under the GNU General Public License from

  2. MD5算法在Web开发中的应用%Application of MD5 in Web Exploitation

    Institute of Scientific and Technical Information of China (English)

    刘啸

    2014-01-01

    介绍了MD5加密技术在Web上的一些应用,给出了MD5加密实现密码在internet上安全传输的完整解决办法,给出了客户端(JavaScript)和服务器端(JavaBeans) MD5算法的实现.

  3. Asymmetries in children's production of relative clauses: data from English and Korean.

    Science.gov (United States)

    Kim, Chae-Eun; O'Grady, William

    2016-09-01

    We report here on a series of elicited production experiments that investigate the production of indirect object and oblique relative clauses by monolingual child learners of English and Korean. Taken together, the results from the two languages point toward a pair of robust asymmetries: children manifest a preference for subject relative clauses over indirect object relative clauses, and for direct object relative clauses over oblique relative clauses. We consider various possible explanations for these preferences, of which the most promising seems to involve the requirement that the referent of the head noun be easily construed as what the relative clause is about. PMID:26264784

  4. 曼尼希反应在木质素的改性中的应用%Application of Mannich Reaction in Modification of Lignin

    Institute of Scientific and Technical Information of China (English)

    岳萱; 乔卫红; 申凯华; 李宗石

    2001-01-01

      本文综述了木质素与脂肪胺的曼尼希反应的机理,反应物的种类和反应条件,并且详细介绍了反应产物木素胺及其衍生物在石油开采、沥青乳化、污水处理、染料分散等方面的应用进展。%  This paper reviews the mechanism, reactants and conditions of the Mannich Reaction which has been used extensively in the modification of lignin with amines. The developments of the applications of lignin amines and derivatives in oil recovery, asphalt emulsion, sewage treatment and dye dispersion have been discussed in detail.

  5. Synthesis of Schiff and Mannich Bases of Isatin Derivatives with 4-Amino-4,5-Dihydro-1H-1,2,4-Triazole-5-Ones

    Directory of Open Access Journals (Sweden)

    Hakan Bektas

    2008-09-01

    Full Text Available Ethyl imidate hydrochlorides 1 were prepared by passing HCl gas through solutions of substituted benzyl cyanides and absolute ethanol. Ethoxycarbonylhydrazones 2 were synthesized from the reaction of compounds 1 with ethyl carbazate. Treatment of 2 with hydrazine hydrate leads to the formation of substituted 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones 3. Isatin and 5-chloroisatin were added to 3 to form Schiff bases 4 and N-Mannich bases 5 of these compounds were synthesized by reacting with formaldehyde and piperidine. Their chemical structures were confirmed by means of IR, 1H- and 13C-NMR data and by elemental analysis.

  6. 33 CFR 110.72 - Blackhole Creek, Md.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Blackhole Creek, Md. 110.72... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.72 Blackhole Creek, Md. The waters on the west side of Blackhole Creek, a tributary of Magothy River, southwest of a line bearing 310°30′ from the most...

  7. 76 FR 51887 - Safety Zone; Patuxent River, Patuxent River, MD

    Science.gov (United States)

    2011-08-19

    ...) entitled ``Safety Zone; Patuxent River, Patuxent River, MD'' in the Federal Register (76 FR 36447). We... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Patuxent River, Patuxent River, MD AGENCY... safety zone during the ``NAS Patuxent River Air Expo '11,'' which consists of aerial...

  8. BI MD studies on August 25th 2011

    CERN Document Server

    Belohrad, D; Boccardi, A; Calvo, E; Dehning, B; Favier, M; Emery, J; Guerrero, A; Lefevre, T; Gras, JJ; Jeff, A; Soby, L; Rabiller, A; Roncarolo, F; Sapinski, M; Steinhagen, R; Mateo, CM

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 25-Aug-2011 (from 5 a.m. to 1 p.m.), dedicated to study Beam Loss Monitors (BLM), Wire Scanners (WS), Synchrotron Radiation (BSRT), Beam Position Monitors (BPM), and Beam Gas Ionization (BGI) monitors. The MD aimed at performing different studies on the individual monitors.

  9. MD5密码极速爆破

    Institute of Scientific and Technical Information of China (English)

    飘零雪

    2009-01-01

    MD5加密技术对我们来说并不陌生,通过MD5值可以校验下载软件的安全性,而且在很多系统中,用户的密码是以MD5值的方式保存的,用户登录时系统是把用户输入的密码计算成MD5值,然后再去和系统中保存的MD5值进行比较,以验证该用户的合法性。MD5值虽看似很安全,但也并非无懈可击,使用“超速md5破解工具”即可简单快捷地尝试解密MD5。

  10. Single-block collision attack on MD5

    NARCIS (Netherlands)

    Stevens, M.M.J.

    2012-01-01

    In 2010, Tao Xie and Dengguo Feng \\cite{cryptoeprint:2010:643} constructed the first single-block collision for MD5 consisting of two 64-byte messages that have the same MD5 hash. Details of their attack, developed using what they call an evolutionary approach, has not been disclosed ``for security

  11. Chosen-Prefix Collisions for MD5 and Applications

    NARCIS (Netherlands)

    Stevens, M.M.J.; Lenstra, A.K.; Weger, B. de

    2012-01-01

    We present a novel, automated way to find differential paths for MD5. Its main application is in the construction of \\emph{chosen-prefix collisions}. We have shown how, at an approximate expected cost of $2^{39}$ calls to the MD5 compression function, for any two chosen message prefixes $P$ and $P'$

  12. Leroy D Vandam, MD: an anesthesia journey.

    Science.gov (United States)

    Ortega, Rafael A

    2005-08-01

    Leroy D Vandam, MD was a remarkable man--an intricate amalgamation of an artist, scientist, and physician. He was a bastion of medical historical knowledge. Dr Vandam became a most influential anesthesiologist, some say, a giant. He was an example of someone who, with resolve, overcame adversity. His artwork is displayed in countless places, and several of his paintings form part of the Wood Library Museum Heritage Series. Dr Vandam was first a surgeon, but he abandoned surgery and pursued a career in anesthesiology under the leadership of Robert Dripps. He completed his residency training at the University of Pennsylvania and joined its staff in 1949. When he arrived at Brigham and Women's Hospital in the 1950s as director of anesthesia, he embarked on one of the most illustrious careers in American anesthesiology. Dr Vandam published more than 250 original articles, chapters, abstracts, and other reports on a wide variety of subjects including history, art, and pharmacology. His classic article on the complications of neuroaxial blocks is a seminal work in anesthesiology. This article describes how an anesthesiologist who shared an interest with Dr Vandam in the history of anesthesiology came to produce a movie based on his career, the evolution of anesthesia equipment, and the transformation of our specialty.

  13. DFT-MD simulations of shocked Xenon

    Science.gov (United States)

    Magyar, Rudolph J.; Mattsson, Thomas R.

    2009-03-01

    Xenon is not only a technologically important element used in laser technologies, jet propulsion and dental anesthesia, but it is also arguably the simplest material in which to study the metal-insulator transition at high pressure. Because of its closed shell electronic configuration, Xenon is often assumed to be chemically inert, interacting almost entirely through the van der Waals interaction, and at liquid density, is typically modeled well using Leonard-Jones potentials. However, such modeling has a limited range of validity as Xenon is known to form compounds at normal conditions and likely exhibits considerably more chemistry at higher densities when hybridization of occupied orbitals becomes significant. In this talk, we present DFT-MD simulations of shocked liquid Xenon with the goal of developing an improved equation of state. The relative importance of the van der Waals interaction compared to other Coulomb interactions is considered, and estimates of the relative accuracy of various density functionals are quantified. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

  14. Influence of sulfur physical properties in Claus unit operation

    Energy Technology Data Exchange (ETDEWEB)

    Larraz Mora, R.; Arvelo Alvarez, R. [Chemical Engineering Dept., Univ. of la Laguna, Tenerife (Spain)

    2002-09-01

    The Claus process is an efficient way of removing H{sub 2}S from acid gas streams and it has been widely practiced in industries such as natural gas processing, oil refining and metal smelting. Increasingly strict pollution control regulations require maximum sulfur recovery and high stream factor from the Claus units in order to minimize sulfur-containing effluents. As has been widely reported Claus unit's damages mainly occur during start up and shutdown. These operations involve scheduled warm-up and cool-down of the unit, usually burning refinery fuel-gas, which if not properly made can produce severe pipe and equipment plugging as well as catalyst deactivation. Sulfur products remaining in the unit during a shutdown period can produce dramatic unit corrosion episodes diminishing sulfur recovery unit stream factor. In the present paper some guidelines are given based on sulfur physical properties singularities which help to improve start-up/shut-down procedures. (orig.)

  15. 48 CFR 1827.305 - Administration of the patent rights clauses.

    Science.gov (United States)

    2010-10-01

    ... patent rights clauses. 1827.305 Section 1827.305 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights Under Government Contracts 1827.305 Administration of the patent rights clauses....

  16. Asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes of glycine Schiff bases. Part 2: aldol, Mannich addition reactions, deracemization and (S) to (R) interconversion of α-amino acids.

    Science.gov (United States)

    Sorochinsky, Alexander E; Aceña, José Luis; Moriwaki, Hiroki; Sato, Tatsunori; Soloshonok, Vadim

    2013-11-01

    This review provides a comprehensive treatment of literature data dealing with asymmetric synthesis of α-amino-β-hydroxy and α,β-diamino acids via homologation of chiral Ni(II) complexes of glycine Schiff bases using aldol and Mannich-type reactions. These reactions proceed with synthetically useful chemical yields and thermodynamically controlled stereoselectivity and allow direct introduction of two stereogenic centers in a single operation with predictable stereochemical outcome. Furthermore, new application of Ni(II) complexes of α-amino acids Schiff bases for deracemization of racemic α-amino acids and (S) to (R) interconversion providing additional synthetic opportunities for preparation of enantiomerically pure α-amino acids, is also reviewed. Origin of observed diastereo-/enantioselectivity in the aldol, Mannich-type and deracemization reactions, generality and limitations of these methodologies are critically discussed.

  17. PEG-OSO3H as an efficient and recyclable catalyst for the synthesis of β-amino carbonyl compounds via the Mannich reaction in PEG-H2O

    Institute of Scientific and Technical Information of China (English)

    Xi Cun Wang; Li Jia Zhang; Zhang Zhang; Zheng Jun Quan

    2012-01-01

    Sulfuric acid-modified polyethylene glycol 6000 (PEG-OSO3H) was applied as an efficient and recyclable catalyst for the synthesis of β-amino carbonyl compounds via the Mannich reaction between aldehydes,aromatic ketones and aromatic amines at room temperature using PEG400-H2O (1∶1) as environment-friendly solvents.The reactions were completed in short times and mild reaction conditions with good to excellent yields.

  18. MD-PhD training: looking back and looking forward.

    Science.gov (United States)

    Bonham, Ann C

    2014-01-01

    MD-PhD programs provide rigorous, integrated training for physician-scientists, enabling them to frame scientific questions in unique ways and to apply clinical insight to fundamental science. Few would question the influential contributions of MD-PhD physician-scientists in advancing medical science. In this issue of Academic Medicine, Jeffe et al affirm high levels of excellence in educational outcomes from MD-PhD training programs at U.S. MD-granting medical schools, especially programs that receive funding from the NIH Medical Scientist Training Program (MSTP). The author of this commentary observes that, in the face of current economic pressures, comprehensive, longitudinal national outcomes data from MSTP- and non-MSTP-funded MD-PhD programs will help verify the value provided by MD-PhD physician-scientists. She proposes that MD-PhD programs should better prepare the next generation of physician-scientists for future research environments, which will provide new technologies, venues, and modalities. These research environments will be more closely integrated within health care delivery systems, extend into diverse communities and regions, and employ complex technologies. MD-PhD physician-scientists also will train and gain expertise in broadening areas of research, such as health policy, health economics, clinical epidemiology, and medical informatics. Program leaders are ideally situated to foster innovative learning environments and methodologies. By sharing their innovations, they can help ensure production of a diverse MD-PhD physician-scientist workforce, prepared to engage in myriad research opportunities to meet patient and population needs in a new environment.

  19. Syntactic and Semantic Coordination in Finite Complement-Clause Constructions: A Diary-Based Case Study

    Science.gov (United States)

    Köymen, Bahar; Lieven, Elena; Brandt, Silke

    2016-01-01

    This study investigates the coordination of matrix and subordinate clauses within finite complement-clause constructions. The data come from diary and audio recordings which include the utterances produced by an American English-speaking child, L, between the ages 1;08 and 3;05. We extracted all the finite complement-clause constructions that L…

  20. 22 CFR 124.9 - Additional clauses required only in manufacturing license agreements.

    Science.gov (United States)

    2010-04-01

    ... manufacturing license agreements. 124.9 Section 124.9 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL... Additional clauses required only in manufacturing license agreements. (a) Clauses for all manufacturing license agreements. The following clauses must be included only in manufacturing license agreements:...

  1. MD 239 on Collide and Squeeze (part 2)

    CERN Document Server

    Gorzawski, Arkadiusz; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; CERN. Geneva. ATS Department

    2016-01-01

    Colliding the beams during the squeeze to profit from Landau damping due to head--on beam-beam and beta--star leveling are two operational modes that may have to be used in a not so distant future at the LHC. This MD aimed at improving the orbit control during the squeeze with much improved handling of orbit feedback references and at evaluating instruments and techniques to maintain the beam in collisions with active feedback on luminosity or beam position. This MD also integrated for the first time synchronized collimator measurements. Comparison of the settings with the previous MD allowed a validation of the long term stability of collide and squeeze.

  2. Single-block collision attack on MD5

    OpenAIRE

    Stevens, Marc

    2012-01-01

    In 2010, Tao Xie and Dengguo Feng \\cite{cryptoeprint:2010:643} constructed the first single-block collision for MD5 consisting of two 64-byte messages that have the same MD5 hash. Details of their attack, developed using what they call an evolutionary approach, has not been disclosed ``for security reasons''. Instead they have posted a challenge to the cryptology community to find a new different single-block collision attack for MD5. This paper answers that challenge by presenting a single-b...

  3. MD5加密算法的研究

    Institute of Scientific and Technical Information of China (English)

    许琪

    2014-01-01

    MD5加密算法做为散列函数的一个重要算法,在文件校验、数字签名等诸多领域有着广泛的应用.虽然MD5加密算法是单向算法,但其仍无法抵御差分攻击和查字典攻击.文章在分析了差分攻击原理的基础上,阐述了MD5加密算法采用差分攻击产生碰撞的方法.

  4. Charge separation reaction in clusters of polar molecules. MD simulations

    International Nuclear Information System (INIS)

    Rate constant of intermolecular electron transfer (ET) in a photoexcited donor-acceptor model system solvated by a cluster of polar molecules has been expressed in terms of the statistical distribution of the electrostatic potential energy difference between the reacting sites. This distribution has been calculated for a particular case of acetonitrile clusters at ∼ 120 K by MD computer simulation. The MD values of the cluster reorganization energy and the ET rate constant have been compared with the corresponding MD results for the donor-acceptor pair solvated in bulk acetonitrile and with theoretical predictions based on the continuum model. (author)

  5. MD5Hash加密算法在SQL Server2005中的应用%Application of MD5 Hash Encryption Algorithm in SQL Server 2005

    Institute of Scientific and Technical Information of China (English)

    李红日

    2011-01-01

    在对MD5算法进行简要描述的同时,对MD5算法的原理作深入分析.介绍在C创建MD5 Hash算法的函数,在SQL Server中应用MD5哈希算法,并且经过测试可以准确实现MD5 Hash加密算法.

  6. Cryptanalysis of the Hash Function MD5%关于Hash函数MD5的解析

    Institute of Scientific and Technical Information of China (English)

    毛明; 陈少晖; 袁征; 贾永兴

    2009-01-01

    This paper is about the cryptanalysis of the Hash function MDS, on the basis of the paper concerning the breaking the MD5 which was written by Wang et al.In this paper,the eighth step of MD5 algorithm was taken for exam-ple and the properties of the F function and the effective control of the differential path were introduced.The MD5 algo-rithm was cryptanalyzed from both the manual calculation and the testing program and some part of the paper written by Wang was amended.Finally, the conditions and key points of meeting the differential characteristics were discussed.In general, this paper plays an important role in eryptanalyzing and breaking the MD5 algorithm.%在王小云写的关于分析MD5算法文章的基础上,对MD5算法的破译进行进一步的解析.以MD5算法第八步为例,介绍了F函数的性质和差分路径的有效控制.从手工推算和程序实现两方面时MD5算法进行了解析和测试,对王的文章进行了部分修正,进一步说明了满足差分特征的条件和关键点.这对MD5和其他Hash函数的分析破译有着重要的作用.

  7. 37 CFR 401.14 - Standard patent rights clauses.

    Science.gov (United States)

    2010-07-01

    ... for the support of scientific research or education; and (4) It will make efforts that are reasonable... research work to be performed by a small business firm or domestic nonprofit organization. The... developmental or research work the patent rights clause required by (cite section of agency...

  8. 48 CFR 3027.305 - Administration of Patent Rights Clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Administration of Patent... SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) SOCIOECONOMIC PROGRAMS PATENTS, DATA, AND COPYRIGHTS Patent Rights under Government Contracts 3027.305 Administration of Patent Rights Clauses....

  9. 48 CFR 970.2702 - Patent related clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Patent related clauses. 970.2702 Section 970.2702 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Patents, Data, and Copyrights 970.2702...

  10. U.S. Foreign Medical Students: After the "Guadalajara Clause"

    Science.gov (United States)

    Walsh, John

    1977-01-01

    The controversial issues surrounding the "Guadalajara Clause" of the Health Professions Educational Assistance Act of 1976 are detailed. At issue is whether Americans studying in foreign medical schools should be admitted to third and fourth year classes if they can pass part one of the National board examinations. (BT)

  11. 48 CFR 511.204 - Solicitation provisions and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... Schedule containing information technology Special Item Numbers; or (ii) Federal Supply Schedules for... contracting officer shall include the clause 552.211-92, Radio Frequency Identification (RFID) using Passive... Consolidated Products and Services Schedule containing information technology Special Item Numbers; or...

  12. 48 CFR 803.570-2 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 803.570-2 Section 803.570-2 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Other Improper Business Practices 803.570-2...

  13. 48 CFR 3.502-3 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clause. 3.502-3 Section 3.502-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Other Improper Business Practices 3.502-3...

  14. 48 CFR 503.570-2 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Other Improper Business Practices 503.570-2 Contract... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract clause. 503.570-2..., including acquisitions of leasehold interests in real property, if the contract amount is expected to...

  15. 48 CFR 3.503-2 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clause. 3.503-2 Section 3.503-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Other Improper Business Practices 3.503-2...

  16. 48 CFR 815.304-71 - Solicitation provision and clause.

    Science.gov (United States)

    2010-10-01

    ..., Service-Disabled Veteran-Owned and Veteran-Owned Small Business Evaluation Factors, in competitively... include VAAR clause 852.215-70, Service-Disabled Veteran-Owned and Veteran-Owned Small Business Evaluation... AFFAIRS CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection...

  17. 48 CFR 16.506 - Solicitation provisions and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... business set-aside, use the clause with its Alternate III (but see subparagraph (5) below). (5) If the... may be acquired on a brand-name basis; and (ii) Involves a partial small business set-aside, use the... REGULATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Indefinite-Delivery Contracts...

  18. The Acquisition of Chinese Relative Clauses: Contrasting Two Theoretical Approaches

    Science.gov (United States)

    Hu, Shenai; Gavarró, Anna; Vernice, Mirta; Guasti, Maria Teresa

    2016-01-01

    This study examines the comprehension of relative clauses by Chinese-speaking children, and evaluates the validity of the predictions of the Dependency Locality Theory (Gibson, 1998, 2000) and the Relativized Minimality approach (Friedmann, Belletti & Rizzi, 2009). One hundred and twenty children from three to eight years of age were tested by…

  19. 41 CFR 60-4.3 - Equal opportunity clauses.

    Science.gov (United States)

    2010-07-01

    ... that the concrete benefits of the program are reflected in the Contractor's minority and female... regulations, or these specifications, the Director shall proceed in accordance with 41 CFR 60-4.8. 14. The...) The equal opportunity clause published at 41 CFR 60-1.4(a) of this chapter is required to be...

  20. 48 CFR 904.404 - Solicitation provision and contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Solicitation provision and contract clause. 904.404 Section 904.404 Federal Acquisition Regulations System DEPARTMENT OF ENERGY... DOE's security authority is derived from the Atomic Energy Act which contains specific language...

  1. THE EFFICACY OF THE ARBITRATION CLAUSE IN A SIMULATED ACT

    Directory of Open Access Journals (Sweden)

    Tudor Vlad RĂDULESCU

    2016-05-01

    Full Text Available The article focuses on the effects that an arbitration clause can still produce when it is contained in a simulated operation, whether it is in the apparent act or in the secret one, depending on the forms of simulation.

  2. 48 CFR 50.206 - Solicitation provisions and contract clause.

    Science.gov (United States)

    2010-10-01

    ... REGULATION CONTRACT MANAGEMENT EXTRAORDINARY CONTRACTUAL ACTIONS AND THE SAFETY ACT Support Anti-terrorism by Fostering Effective Technologies Act of 2002 50.206 Solicitation provisions and contract clause. (a) Insert the provision at 52.250-2, SAFETY Act Coverage Not Applicable, in solicitations if— (1) The...

  3. 48 CFR 5416.203-4 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Contract clauses. 5416.203-4 Section 5416.203-4 Federal Acquisition Regulations System DEFENSE LOGISTICS AGENCY, DEPARTMENT OF... established price or cost index may be derived from sales prices in the marketplace, quotes, or assessments...

  4. Word order variation and foregrounding of complement clauses

    DEFF Research Database (Denmark)

    Christensen, Tanya Karoli; Jensen, Torben Juel

    2015-01-01

    Through mixed models analyses of complement clauses in a corpus of spoken Danish we examine the role of sentence adverbials in relation to a word order distinction in Scandinavian signalled by the relative position of sentence adverbials and finite verb (V>Adv vs. Adv>V). The type of sentence...

  5. 48 CFR 32.206 - Solicitation provisions and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Solicitation provisions and contract clauses. 32.206 Section 32.206 Federal Acquisition Regulations System FEDERAL ACQUISITION...) of this section); (iii) Liquidation of those financing payments by delivery payments (see...

  6. 48 CFR 32.502-4 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clauses. 32.502-4 Section 32.502-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING... concerns for the progress payment and liquidation rate indicated. (3) If an unusual progress payment...

  7. Coreference relations in complex sentence with a complement clause

    Directory of Open Access Journals (Sweden)

    Moskovljević-Popović Jasmina D.

    2015-01-01

    Full Text Available The main purpose of this paper is to analyze different co reference relations which can be established in a complex sentence between one of the arguments of the matrix clause and the understood/implicit subject of the complement clause introduced by the complementizer “da”. Various patterns of control relations which are present in contemporary Serbian - obligatory, non-obligatory, and shared control - have been enumerated and exemplified. Different types of constructions and different classes of verbs which introduce (or may introduce control relations have been identified and patterns of control instantiated by them have been described. It has been argued that the analysis of the Serbian data indicates that a type of the matrix predicate is not the only factor which determines the control relations established in a complex sentence, but that a type of situation/event described in the complement clause, as well as the relationship between the events denoted by the matrix and the complement clauses have their influence too. [Projekat Ministarstva nauke Republike Srbije, br. 178004: Standardni srpski jezik: sintaksička, semantička i pragmatička istraživanja

  8. From Sound to Syntax: The Prosodic Bootstrapping of Clauses

    Science.gov (United States)

    Hawthorne, Kara

    2013-01-01

    It has long been argued that prosodic cues may facilitate syntax acquisition (e.g., Morgan, 1986). Previous studies have shown that infants are sensitive to violations of typical correlations between clause-final prosodic cues (Hirsh-Pasek et al., 1987) and that prosody facilitates memory for strings of words (Soderstrom et al., 2005). This…

  9. Arbitration clauses in contracts between providers and patients.

    Science.gov (United States)

    Buckner, F

    1998-01-01

    Arbitration clauses in contracts between health care providers and their patients can offer benefits to both parties. However, practitioners need to ensure that their contracts will not be judged unenforceable by a court. This article outlines the contractual and constitutional issues involved in arbitration agreements and provides advice to practitioners on drafting such an agreement. PMID:10662267

  10. 48 CFR 27.409 - Solicitation provisions and contract clauses

    Science.gov (United States)

    2010-10-01

    ... business innovation research contract (see paragraph (h) of this section); (iv) To be performed outside the... determines, in accordance with 27.404-2(b), to adopt the alternate definition of “Limited Rights Data” in... the contract is a Small Business Innovation Research (SBIR) contract, insert the clause at...

  11. Relative clauses in Suriname creoles and Gbe languages

    NARCIS (Netherlands)

    G.L. Huttar; E.O. Aboh; F.K. Ameka

    2013-01-01

    Two creoles of Suriname, Ndyuka and Saramaccan, are compared with each other and with Western Gbe, Eastern Gbe, and other languages of West Africa with respect to relative clause formation. Relativization strategies are described for the syntactic positions subject, direct object, and indirect objec

  12. 48 CFR 5119.1071 - Solicitation provisions and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... THE ARMY ACQUISITION REGULATIONS SMALL BUSINESS AND SMALL DISADVANTAGED BUSINESS CONCERNS Small Business Competitiveness Demonstration Program 5119.1071 Solicitation provisions and contract clauses. (a) DFARS provision 252.219-7012 shall be inserted in all solicitations issued under the Small...

  13. 48 CFR 1535.007-70 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... the Clean Air Act (42 U.S.C. 7401 et seq.), the Federal Water Pollution Control Act (33 U.S.C. 1251 et seq.), the Safe Drinking Water Act (42 U.S.C. 300f et seq.), the Federal Food, Drug, and Cosmetic Act... shall insert the clause at 48 CFR 1552.235-71, Treatment of Confidential Business Information,...

  14. 48 CFR 1427.201-2 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1427.201-2 Section 1427.201-2 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR GENERAL... the CCO with legal review and concurrence....

  15. 48 CFR 25.1103 - Other provisions and clauses.

    Science.gov (United States)

    2010-10-01

    ... SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Solicitation Provisions and Contract Clauses 25.1103 Other provisions..., in solicitations and contracts if anticipating translation into another language. (c) Foreign... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Other provisions...

  16. 48 CFR 2825.901 - Omission of audit clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Omission of audit clause. 2825.901 Section 2825.901 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE Socioeconomic... in by the contracting activity's legal counsel prior to being approved by the authorized...

  17. Find an Orthopaedic Foot and Ankle MD/DO

    Science.gov (United States)

    ... page. Home Contact Us FootCareMD Currently selected About Us Overview of Foot & Ankle Glossary of Foot & Ankle Terms Adult Foot Health ... Map American Orthopaedic Foot & Ankle Society ® Orthopaedic Foot ... US) Copyright © 2016 All Rights Reserved

  18. Autentikasi Pesan Menggunakan Algoritma Message Digest 5 (MD5)

    OpenAIRE

    Simamora, Ali Makmur

    2015-01-01

    When receive or send a message on the network internet, there are some issue which very important namely problem wholeness and authentication. This script discusses about authentication of message with Message Digest algorithm 5. The writter designed an application to ensure the integrity of the message by algorithm MD5. MD5 is a tool to declare the validity of (authentic) sent messages as well as message. To express validity of message in the text or file will used encryption method, so the ...

  19. Waiting time distribution in M/D/1 queueing systems

    DEFF Research Database (Denmark)

    Iversen, Villy Bæk; Staalhagen, Lars

    1999-01-01

    The well-known formula for the waiting time distribution of M/D/1 queueing systems is numerically unsuitable when the load is close to 1.0 and/or the results for a large waiting time are required. An algorithm for any load and waiting time is presented, based on the state probabilities of M/D/1....... The principles are also applicable for other queueing systems...

  20. Research of the Hash Algorithm Based on MD5%MD5散列算法的研究

    Institute of Scientific and Technical Information of China (English)

    姜学军; 曹烨

    2014-01-01

    借鉴了M.M.J.Stevens的碰撞思路,重新编写了MD5碰撞算法中的核心循环,主要提供一对MD5碰撞产生的过程以及碰撞的完成.通过实验统计分析,利用改进的MD5碰撞算法找到一对碰撞信息所用平均时间不多于60s,且该算法较之传统的MD5碰撞算法具有更好的可读性和可移植性.

  1. Claus plant tail gas treatment; Traitement des gaz de queue du procede claus

    Energy Technology Data Exchange (ETDEWEB)

    Lavalley, J.C.; Laperdrix, E. [Institut des Sciences de la Matiere et du Rayonnement, UMR 6506, Lab. Catalyse et Spectrochimie, 14 - Caen (France); Universite Chouaib Doukali, Faculte des Sciences, Lab. de Chimie Physique, El Jadida (Morocco)

    2002-07-01

    Tail gas of Claus plants generally contains COS, CS{sub 2} and H{sub 2}S. In order to satisfy the new environmental requirements, COS and CS{sub 2} hydrolysis have to be improved, whereas the oxidation of H{sub 2}S in sulfur, S{sub n}, appears to be one of the most satisfactory processes for the removal of slight amounts of H{sub 2}S. IR studies evidence that sulfate species are reduced by H{sub 2}S at 320 deg C on TiO{sub 2}, contrary to results obtained on Al{sub 2}O{sub 3}, explaining why TiO{sub 2} is much more effective than alumina when the CS{sub 2} + H{sub 2}O feed also contains H{sub 2}S and O{sub 2} traces. A CuO/Al{sub 2}O{sub 3} catalyst was used for selective oxidation of H{sub 2}S into sulfur at 110 deg C. It is shown that polysulfide species are formed during the reaction, constituting an uniqueness of this catalyst. Elemental sulfur appears from the cleavage of too-long polysulfide chains. Storage of sulfur in the catalyst porosity provokes its deactivation whereas the catalyst ability to form sulfate species is poor. (author)

  2. 基于MD5和Session的PHP安全防范%PHP security based on Session and MD5

    Institute of Scientific and Technical Information of China (English)

    何秉荣

    2014-01-01

    根据Session工作原理和MD5算法的特性,分析了PHP中Session欺骗与攻击手段,并较有针对性地在防范Session攻击的技术中结合MD5函数,从而提出了一个较为有效、实用的防范措施.

  3. STUDY ON THE MANNICH REACTION OF PAM INVERSE MICROLATICES%丙烯酰胺反相微胶乳的Mannich反应研究

    Institute of Scientific and Technical Information of China (English)

    赵勇; 何炳林

    2001-01-01

    The Mannich reaction of PAM inverse microl atices were carried out in the way of microreactor for the first time, which gua ranted the balance and steadiness of reaction because of avoiding the coacervati on of microlatex particles. The experiment shows that temperature and pH value are the important influencing factors on product properties. In the experimental condition of temperature at 50 ℃ and pH at 2, aminated PAM inverse microlatices were prepared, of which amination degree was 58% and storage stability was one year.%首次选用微乳液反应器形式进行了PAM反相微胶乳的Mannich反应,由于避免了因胶乳粒子凝聚而出现的破乳现象,使得反应均衡和平稳。研究发现,温度和pH是影响产物性能的重要因素 。在T=50 ℃,pH=2的条件下,制得了胺化度为58%,稳定性长达1 a的胶乳产品。

  4. Synthesis, growth, optical and DFT calculation of 2-naphthol derived Mannich base organic non linear optical single crystal for frequency conversion applications

    Science.gov (United States)

    Raj, A. Dennis; Jeeva, M.; Shankar, M.; Purusothaman, R.; Prabhu, G. Venkatesa; Potheher, I. Vetha

    2016-11-01

    2-naphthol derived Mannich base 1-((4-methylpiperazin-1-yl) (phenyl) methyl) naphthalen-2-ol (MPN) - a nonlinear optical single crystal was synthesized and successfully grown by slow evaporation technique at room temperature. The molecular structure was confirmed by single crystal XRD, FT-IR, 1H NMR and 13C NMR spectral studies. The single crystal X-ray diffraction analysis reveals that the crystal belongs to orthorhombic crystal system with non-centrosymmetric space group Pna21. The chemical shift of 5.34 ppm (singlet methine CH proton) in 1H NMR and signal for the CH carbon around δ70.169 ppm in 13C NMR confirms the formation of the title compound. The crystal growth pattern and dislocations of crystal are analyzed using chemical etching technique. UV cut off wavelength of the material was found to be 212 nm. The second harmonic generation (SHG) of MPN was determined from Kurtz Perry powder technique and the efficiency is almost equal to that of standard KDP crystal. The laser damage threshold was measured by passing Nd: YAG laser beam through the sample and it was found to be 1.1974 GW/cm2. The material was thermally stable up to 142 °C. The relationship between the molecular structure and the optical properties was also studied from quantum chemical calculations using Density Functional Theory (DFT) and reported for the first time.

  5. Synthesis of formazans from Mannich base of 5-(4-chlorophenyl amino-2-mercapto-1,3,4-thiadiazole as antimicrobial agents

    Directory of Open Access Journals (Sweden)

    Pramilla Sah

    2014-04-01

    Full Text Available 5-(4-Chlorophenyl amino-2-mercapto-1,3,4-thiadiazole (I was refluxed with formaldehyde and ammonium chloride in ethanol yielding the Mannich base 5-(4-chloro phenyl amino-3-aminomethyl-2-mercapto-1,3,4-thiadiazole (II. Esterification with 4-chloro-(2,6-dinitro phenoxy-ethyl acetate (III under anhydrous conditions gave the intermediate (IV. Subsequent hydrazinolysis with hydrazine hydrate gave the corresponding hydrazide 3-amino methyl-5-(4-chloro phenyl amino-2-mercapto-4′-(2′,6′-dinitro phenoxy-acetyl hydrazide (V. The hydrazide was converted into the Schiff bases (VIa–b by reacting with 2-chlorobenzaldehyde and 3-methoxy-4-hydroxy benzaldehyde in presence of methanol containing 2–3 drops of acetic acid. Diazotisation with aromatic amines, sulphanilic acid and sulphur drugs gave the formazans (VIIa–g respectively. Chemical structures have been established by elemental analysis and the spectral techniques of FTIR, 1H NMR and mass. Antimicrobial activity (in vitro was evaluated against the two pathogenic bacterial strains. Escherichia coli and Salmonella typhi, three fungal strains Aspergillus niger, Penicillium species and Candida albicans. The compounds have shown moderate activity.

  6. Cummins MD & HD Accessory Hybridization CRADA -Annual Report FY15

    Energy Technology Data Exchange (ETDEWEB)

    Deter, Dean D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-10-01

    There are many areas of MD and HD vehicles that can be improved by new technologies and optimized control strategies. Component optimization and idle reduction need to be addressed, this is best done by a two part approach that includes selecting the best component technology, and/or architecture, and optimized controls that are vehicle focused. While this is a common focus in the light duty industry it has been gaining momentum in the MD and HD market as the market gets more competitive and the regulations become more stringent. When looking into systems optimization and idle reduction technologies, affected vehicle systems must first be considered, and if possible included in the new architecture to get the most benefit out of these new capabilities. Typically, when looking into idle reduction or component optimization for MD/HD, the vehicle s accessories become a prime candidate for electrification or hybridization. While this has already been studied on light duty vehicles (especially on hybrids and electric vehicles) it has not made any head way or market penetration in most MD and HD applications. If hybrids and electric MD and HD vehicles begin to break into the market this would be a necessary step into the ability to make those vehicles successful by allowing for independent, optimized operation separate from the engine.

  7. The acquisition of mood selection in Spanish relative clauses.

    Science.gov (United States)

    Pérez-Leroux, A T

    1998-10-01

    Although children acquire Spanish subjunctive morphology early in the process of language acquisition, they only master mood selection in a staged process that lasts for several years. This paper examines the possibility that the acquisition of subjunctive mood selection in particular syntactic contexts is constrained by cognitive development in the area of representational theory of mind. Acquisition of the epistemic aspects of the semantics of subjunctive are shown to be associated with the understanding of false beliefs, a landmark development in children's cognition. Twenty-two Spanish speaking children between the ages of 3;5 and 6;11 participated in an elicited production study designed to test whether children's ability to produce subjunctive relative clauses was related to their ability to pass a false belief task. Results indicate a strong correlation between children's ability to use the subjunctive mood in relative clauses and their capacity for understanding false beliefs.

  8. 基于C#的MD5加密算法的应用%Application of the MD5 algorithm based on C#

    Institute of Scientific and Technical Information of China (English)

    林宗朝

    2011-01-01

    介绍了WEB SYSTEM中的密钥安全性能。主要讨论了WEB SYSTEM中MD5加密算法,包含客户password安全性分析、MD5加密算法概述、基于C#的MD5加密应用介绍,以及IT SYSTEM中MD5算法的应用与IMPROVEMENT等问题。%The key safety properties of the WEB system is described,and the.MD5 encryption algorithm is discussed mainly including the user password security analysis,MD5 encryption algorithm summary,MD5 encryption applications based on the C# and the improvement of MD5 algorithm.

  9. Using Boolean Constraint Propagation for Sub-clause Deduction

    OpenAIRE

    Darras, Sylvain; Dequen, Gilles; Devendeville, Laure; Mazure, Bertrand; Ostrowski, Richard; Sais, Lahkdar

    2005-01-01

    Boolean Constraint Propagation (BCP) is recognized as one of the most use- ful technique for efficient satisfiability checking. In this paper a new extension of the scope of boolean constraint propagation is proposed. It makes an original use of BCP to achieve further reduction of boolean formulas. Considering the impli- cation graph generated by the constraint propagation process as a resolution tree, sub-clauses from the original formula can be deduced. Then, we show how such extension can ...

  10. The Appositive NP-Complement Clause and Restructuring

    OpenAIRE

    Inada, Shun'ichiro

    2005-01-01

    This paper examines properties of Japanese Af-ga-aru construction involving an appositive NP-complement clause and presents a new approach to restructuring. The new analysis can explain the monoclausality of. sentences with an appositive NP-complement as well as that of restructuring constructions with a VP-complement. I will show that the former construction has the same properties as the latter while the former cannot be restructured at base structure or by overt operations based on two poi...

  11. Development of Relative Clause Constructions in English L2

    Directory of Open Access Journals (Sweden)

    Yumiko Yamaguchi

    2016-01-01

    Full Text Available This study explores how relative clause (RC constructions develop in the acquisition of English as a second language (L2. The acquisition of RC constructions has been the focus of much research in the field of language acquisition, but a majority of L2 studies in this area is experimental based on the Noun Phrase Accessibility Hierarchy (NPAH (Keenan & Comrie, 1977. In this study, the spontaneous speech production by a Japanese primary school child, learning English in a naturalistic environment, was audio-recorded regularly over two years, and the development of RC constructions was compared with the acquisition of other English morphological and syntactic structures as represented within Processability Theory (PT (Pienemann, 1998; Pienemann, Di Biase, & Kawaguchi, 2005; Pienemann & Keßler, 2011. Although PT predicts that subordinate clauses are acquired at the highest stage in processability hierarchy, the results in this longitudinal study show that some types of RC constructions emerge at earlier stages in L2 English acquisition. The results also show that RC constructions in the Japanese child’s English L2 develop in the similar way to those reported in L1 studies (e.g., Diessel, 2004.Keywords: relative clause constructions, English L2, Processability Theory, the Noun Phrase Accessibility Hierarchy, Japanese child

  12. CoMD Implementation Suite in Emerging Programming Models

    Energy Technology Data Exchange (ETDEWEB)

    2014-09-23

    CoMD-Em is a software implementation suite of the CoMD [4] proxy app using different emerging programming models. It is intended to analyze the features and capabilities of novel programming models that could help ensure code and performance portability and scalability across heterogeneous platforms while improving programmer productivity. Another goal is to provide the authors and venders with some meaningful feedback regarding the capabilities and limitations of their models. The actual application is a classical molecular dynamics (MD) simulation using either the Lennard-Jones method (LJ) or the embedded atom method (EAM) for primary particle interaction. The code can be extended to support alternate interaction models. The code is expected ro run on a wide class of heterogeneous hardware configurations like shard/distributed/hybrid memory, GPU's and any other platform supported by the underlying programming model.

  13. BI MD Studies on June 29th 2011

    CERN Document Server

    Belohrad, D; Bravin, E; Calvo, E; Dehning, B; Emery, J; Favier, M; Gras, JJ; Guerrero, A; Jeff, A; Lefevre, T; Rabiller, A; Roncarolo, F; Sapinski, M; Soby, L; Steinhagen, R

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 29-June-2011 (from 10 p.m. to 07 a.m.), dedicated to study Beam Current Monitors (BCT), Wire Scaners (WS), Synchrotron Radiation (BSRT), Beam Position (BPM), Wall Current (WCM) and Beam Gas Ionization (BGI) monitors. The MD aimed at performing different studies on the individual monitors. At the same time, it was possible to perform calibration studies with the Abort Gap (AGM) and Longitudinal Density (LDM) monitors that share the extracted light with the BSRT. Additionally some observations about the beam stability and emittance dependence on the chromaticity were performed.

  14. Analysis of the message digest algorithm MD5%报文摘要算法MD5分析

    Institute of Scientific and Technical Information of China (English)

    燕辉; 叶震; 董泽浩; 高柯俊

    2002-01-01

    随着计算机网络的发展,社会对网络安全的要求也越来越紧迫。文章回顾了网络安全的目标、几种网络攻击方法和网络安全技术,重点分析了普遍用在数据签名中的MD5报文摘要算法。首先描述了MD5报文摘要算法,并对其进行了详细分析,找出了它的缺陷,最后推荐了一种为克服此缺陷而对MD5算法进行的改进方法。

  15. Hardware Implementation of HMAC-MD5 Algorithm%HMAC-MD5算法的硬件实现

    Institute of Scientific and Technical Information of China (English)

    吴旭凡; 胡晨; 田渊; 丁黄胜

    2003-01-01

    信息安全体系中的消息验证是一个非常重要的方面.采用以散列函数为基础的消息验证编码是其中的一种重要方法.现提出了硬件实现一种以MD5算法为基础的消息验证编码(HMAC-MD5)的电路结构.该电路结构通过对MD5核心运算模块的复用,缩小了电路规模,达到了较高的处理速度.用VerilogHDL描述电路结构,并且在FPGA上验证了该结构的正确性.

  16. Licensing clausal complements : The case of Russian čto-clauses

    OpenAIRE

    Knyazev, M

    2016-01-01

    This dissertation describes and explains the distribution of Russian complement clauses with the complementizer čto. It is shown that complement clauses with čto display distributional restrictions that are not manifested by their English and Dutch counterparts and that do not follow from the standard account of complement clauses in the literature. Two classes of environments are discussed where such restrictions are observed, namely, complements of speech act verbs in their non-agentive use...

  17. Research and Improvement of MD5 Algorithm%MD5算法的研究与改进

    Institute of Scientific and Technical Information of China (English)

    毛熠; 陈娜

    2012-01-01

    MD5 algorithm has important applications in the field of data encryption such as digital signature, identity authentication and so on, but it can not resist differential attack and dictionary attack. This paper does certain special transform on some related variables during message preprocessing course of MD5 to improve probability of data high overflow, and increase the avalanche effect and difficulty of differential cryptanalysis, so that collision problem of MD5 algorithm is solved. Through doing collision detection, coincidence detection of encrypted values before and after improvement for improved algorithm, the improved MD5 is proved safe and practical.%MD5算法在数字签名、身份认证等数据加密领域有重要的应用,但其无法抵御差分攻击和查字典攻击.为此,通过对算法消息处理过程中涉及的一些变量进行特殊变换,提高运算中数据高位溢出的几率,增强其雪崩效应,增加差分分析的难度,由此解决MD5算法的碰撞问题.对改进的算法进行碰撞检测、加密值重合检测以及改进前后加密值的重合检测,结果证明其具有较高的安全性和实用价值.

  18. Nuevos aspectos de la reacción tipo mannich en medio básico de 1,3,6,8-tetrazatriciclo[4.4.1.13,8] dodecano (tatd) con fenoles

    OpenAIRE

    Augusto Rivera; Jaime Rios Motta; Ariel Rodolfo Quevedo; Pedro Joseph Nathan

    2008-01-01

    Se ensayaron algunos fenoles como nucleófilos en la reacción tipo Mannich en medio básico frente al aminal macrocíclico1,3,6,8-tetrazatriciclo[4.4.1.1 3,8] dodecano (TATD). Dependiendo del grado de sustitución del fenol empleado, se obtuvieron:1,3- bis- [2’- hidroxibencil] imidazolidinas regioselectivamente, 2,6-di[3’-(2’’-hidroxibencil)-1’-metilenimidazolidin] fenoles y 3,3’-etilen-bis-(3,4-dihidro-2H- 1,3-benzoxazinas).

  19. 基于乙酸为溶剂和催化剂的芳乙酮Mannich反应%Mannich Reaction of Aromatic Ketones Based on Acetic Acid as Solvent and Catalyst

    Institute of Scientific and Technical Information of China (English)

    卜辉娟; 张静; 穆博帅; 李媛

    2014-01-01

    Mannich reaction is one of the most important methods for preparation ofβ-amino ketones and alde-hydes and α,β-unsaturated carbonyl compounds, as well as one of the most important basic reaction types in organic chemistry and it is widely applied as a key step in the synthesis of numerous pharmaceuticals and natu-ral products. However, during the synthesis of 1-aryl acrylic ketone 2 by the Mannich reaction of aromatic ke-tones, formaldehyde and secondary amine using acetic acid as solvent and catalyst, the Mannich base and ex-pectedα,β-unsaturated ketones 2 were not obtained and another kind of compounds 3 , 2-aryl formyl allyl ace-tate were obtained in moderate to good yields(65%-73%) . The structure of compounds 3 was confirmed by 1 H NMR, 13 C NMR, HRMS and IR spectra. The reasons of producing compounds 3 were studied and the re-sults suggested that the special structure of aromatic ketones and excess acetic acid in reaction are responsible for the exceptional Mannich reaction. In addition, the reaction mechanism was postulated.%采用乙酸作溶剂和催化剂,将芳乙酮与甲醛和二级胺进行Mannich反应及热解反应,并未得到预期的Mannich碱或α,β-不饱和酮(2),而是以较高产率(65%~73%)生成了乙酸(2-芳甲酰基)烯丙酯(3a~3o)。通过核磁共振波谱、高分辨质谱和红外光谱表征了化合物3a~3o的结构,研究了此“异常”反应的发生条件,并提出了可能的反应机理。结果表明,芳乙酮的特殊结构及反应中过量的乙酸是产生化合物3a~3o的决定因素。

  20. Research of MD5 shadow table method based on MD5 algorithm%一种融入MD5的影子表算法研究

    Institute of Scientific and Technical Information of China (English)

    袁满; 康峰峰; 黄刚

    2013-01-01

    As for the rapid extraction of source data, the rapid identification of changing data and the rapid incremental extraction of data, underlying the analysis of the working principle of the traditional shadow table, this paper proposed a kind of improved linear algorithm which merged MD5 algorithm into the ST. It scanned compared tables for the linear and eliminates unnecessary inverse operation. During scanning these tables, it employed MD5 algorithm to calculate the whole record ' fingerprint ' , it reduced the frequency and duration of string matching, and it could quickly recognize the changed records. The algorithm was verified practically, and the result shows that the proposed algorithm can improve the efficiency of data extraction in database. Incremental extraction method based on shadow table is a general incremental capturing method, and it can be implemented in any database. These applications can easily be transplanted in all kinds of platforms, so it is suitable to solve the heterogeneous database replication issues.%为了快速提取源头数据、快速识别变化记录以及实现数据的快速增量提取,在剖析传统影子表法的工作原理上,提出基于MD5算法的影子表法的改进型线性算法,对对比表进行线性扫描,排除了不必要的回扫操作;同时通过MD5算法计算整条记录的“指纹”,降低了字符串比对次数和时间,能够迅速识别出发生变化的记录.对所提出算法进行了应用测试,结果表明通过融入MD5算法后的影子表法提高了数据提取效率.基于影子表的增量提取方法是一种通用的增量捕获方法,能在任何数据库上实现;应用程序可以方便地在多种平台间移植,因此很适合解决异构数据库复制问题.

  1. 76 FR 36447 - Safety Zone; Patuxent River, Patuxent River, MD

    Science.gov (United States)

    2011-06-22

    ..., 2008, issue of the Federal Register (73 FR 3316). Public meeting We do not now plan to hold a public... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Patuxent River, Patuxent River, MD AGENCY... a temporary safety zone during the ``NAS Patuxent River Air Expo '11'', which consists of...

  2. 77 FR 12476 - Drawbridge Operation Regulation; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2012-03-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Curtis Creek, Baltimore..., across Curtis Creek, mile 1.0, at Baltimore, MD. This deviation allows the bridge to operate on...

  3. 75 FR 54069 - Drawbridge Operation Regulations; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2010-09-03

    ... (75 FR 30747-30750). The rulemaking concerned eliminating the need for a bridge tender by allowing the... SECURITY Coast Guard 33 CFR Part 117 RIN 1625--AA09 Drawbridge Operation Regulations; Curtis Creek... Avenue Bridge, at mile 0.9, across Curtis Creek at Baltimore, MD. The requested change would have...

  4. 76 FR 9225 - Drawbridge Operation Regulation; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2011-02-17

    ... Regulations; Curtis Creek, Baltimore, MD'' in the Federal Register (74 FR 50707). The temporary deviation... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Curtis Creek, Baltimore... changing the drawbridge operation regulations of the Pennington Avenue Bridge, across Curtis Creek, mile...

  5. 75 FR 1705 - Drawbridge Operation Regulations; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2010-01-13

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulations; Curtis Creek... operation of the I695 Bridge across Curtis Creek, mile 0.9, at Baltimore, MD. The deviation is necessary to... section of Curtis Creek and the bridge will not be able to open in the event of an emergency. Coast...

  6. 75 FR 50707 - Drawbridge Operation Regulation; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2010-08-17

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Curtis Creek, Baltimore... operation of the Pennington Avenue Bridge, across Curtis Creek, mile 0.9, at Baltimore, MD. This deviation... vessels bound for the Coast Guard Yard at Curtis Bay, as well as a significant amount of commercial...

  7. 78 FR 3496 - Maryland Disaster Number MD-00025

    Science.gov (United States)

    2013-01-16

    ... ADMINISTRATION Maryland Disaster Number MD-00025 AGENCY: U.S. Small Business Administration. ACTION: Amendment 3... completed loan applications to: U.S. Small Business Administration, Processing and Disbursement Center... Disaster Assistance, U.S. Small Business Administration, 409 3rd Street SW., Suite 6050, Washington,...

  8. 77 FR 74908 - Maryland Disaster Number MD-00025

    Science.gov (United States)

    2012-12-18

    ... ADMINISTRATION Maryland Disaster Number MD-00025 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1... completed loan applications to: U.S. Small Business Administration, Processing and Disbursement Center... Disaster Assistance, U.S. Small Business Administration, 409 3rd Street SW., Suite 6050, Washington,...

  9. 77 FR 73967 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Science.gov (United States)

    2012-12-12

    ... Regulation; Bear Creek, Dundalk, MD'' in the Federal Register (77 FR 5201). The rulemaking concerned would... proposed rulemaking the bridge owner displayed on the Wise Avenue Bridge signage that stated a 48-hour advance notice was required to open the draw bridge. This signage portrayed improper...

  10. Improved Collision Attack on Hash Function MD5

    Institute of Scientific and Technical Information of China (English)

    Jie Liang; Xue-Jia Lai

    2007-01-01

    In this paper, we present a fast attack algorithm to find two-block collision of hash function MD5.The algorithm is based on the two-block collision differential path of MD5 that was presented by Wang et al.In the Conference EUROCRYPT 2005.We found that the derived conditions for the desired collision differential path were not sufficient to guarantee the path to hold and that some conditions could be modified to enlarge the collision set.By using technique of small range searching and omitting the computing steps to check the characteristics in the attack algorithm, we can speed up the attack of MD5 efficiently.Compared with the Advanced Message Modification technique presented by Wang et al.,the small range searching technique can correct 4 more conditions for the first iteration differential and 3 more conditions for the second iteration differential, thus improving the probability and the complexity to find collisions.The whole attack on the MD5 can be accomplished within 5 hours using a PC with Pentium4 1.70GHz CPU.

  11. 天然黄酮Mannich碱衍生物的合成及生物活性研究%Synthesis and Bioactivity of Natural Flavones Mannich Base Derivatives

    Institute of Scientific and Technical Information of China (English)

    刘重阳; 阮文山; 王盛淳; 汪秋安

    2016-01-01

    Two naturally occurring flavones,apigenin-5,4′-dimethy ether(1) and lutedin-5,3′,4′-trimethyl ether(2),were synthesized through I2/Py dehydrogenation,O-methylation and glycoside hydrolysis reaction,using naringin and hesperidin as raw materials. Based on Mannich reaction of flavones 1 or 2 with various secondary amines and formaldehyde in acidic alcohol solvent with microwave assisted,fifteen novel flavones Mannich base derivatives 1-17 were synthesized. The structures of all synthesized compounds were confirmed by 1H NMR,13C NMR and MS techniques. Furthermore,all compounds were tested for anti-proliferative activities on human cervical carcinoma Hela cells using cell counting Kit-8(CCK-8). The results showed that compounds 1,2,7, 9,10,12 and 17 exhibited distinct anti-proliferative activities against Hela cells. Among them,compounds 10,12 and 17 displayed higher activities with inhibitory concentration 50%(IC50) of 16.13, 29.04 and 9.14 μmol/L than the positive control cis-platin (IC50 =41. 25 μmol/L).%以柚皮苷和橙皮苷为原料,经碘/吡啶脱氢,O-甲基化和糖苷水解等反应,分别合成了2种天然黄酮芹菜素-5,4′-二甲醚(1)和木犀草素-5,3′,4′-三甲醚(2)。然后以1和2为底物,分别与甲醛、二级胺在酸性醇溶剂中发生微波协助的Mannich反应,对黄酮8-位进行胺甲基化修饰,合成了15个新型黄酮Mannich碱衍生物3~17。所合成的化合物经1H NMR、13C NMR和MS等进行了结构确证,并采用细胞计数Kit-8(CCK-8)法测试了化合物1~17对子宫颈癌Hela细胞的体外抑制活性。结果表明,化合物1、2、7、9、10、12和17对Hela细胞增殖具有明显的抑制活性,其中化合物10、12和17的半数抑制浓度( IC50)分别为16.13、29.04和9.14μmol/L,活性高于阳性对照药物顺铂(IC50为41.25μmol/L)。

  12. 基于MD5的迭代散列算法%Iterative Hashing Algorithm Based on MD5

    Institute of Scientific and Technical Information of China (English)

    张青

    2011-01-01

    The paper analyzes the user name and password storage methods and their risks on the internet. On this basis, it analyzes MD5 message digest encryption weaknesses and deciphering means. In response to these decoding methods, it proposes an iterative algorithm based on MD5. This algorithm is immune to the second birthday attack, meanwhile improve the complicates of the the first birthday attack. It is also useful for rainbow table attack. The algorithm can enhance password security features, thereby enhancing the network information transmission and storage security.%分析网络中用户名、密码的存储方式及其存在的风险.在此基础上分析MD5散列算法的弱点及其破译手段.针对这些破泽方法提出基于MD5的迭代散列算法.该算法可以避免第二类生日攻击,并有效提高第一类生日攻击的复杂度,对于破解效率最高的彩虹表也具有免疫性,能够加强密码的安全性能,从而提高网络中信息传递和存储的安全性.

  13. Integrating Conflict Driven Clause Learning to Local Search

    Directory of Open Access Journals (Sweden)

    Gilles Audenard

    2009-10-01

    Full Text Available This article introduces SatHyS (SAT HYbrid Solver, a novel hybrid approach for propositional satisfiability. It combines local search and conflict driven clause learning (CDCL scheme. Each time the local search part reaches a local minimum, the CDCL is launched. For SAT problems it behaves like a tabu list, whereas for UNSAT ones, the CDCL part tries to focus on minimum unsatisfiable sub-formula (MUS. Experimental results show good performances on many classes of SAT instances from the last SAT competitions.

  14. The Verb Always Leaves IP in V2 Clauses

    DEFF Research Database (Denmark)

    Schwartz, Bonnie D.; Vikner, Sten

    2007-01-01

    analysis in which the verb moves into an Xº which is the sister of IP may be compatible with what we say here. Various alternatives to this analysis have been explored in the literature, and here we will address two in particular: One alternative is that there is an asymmetry between subject......-initial and non-subject-initial V2 clauses, the former being only IPs and the latter CPs, as suggested by Travis (1984, 1986, 1991) and Zwart (1990, 1991). Below we will refer to this analysis as the 'V2 asymmetry' analysis. The other alternative analysis is that V2 takes place inside IP, as suggested by Diesing...

  15. Signaling Elaboration: Combining French Gerund Clauses with Lexical Cohesion Cues

    Directory of Open Access Journals (Sweden)

    Marianne Vergez-Couret

    2012-07-01

    Full Text Available In this paper, we focus on the Elaboration relation and on its automatic identification in French, using the theoretical framework of Segmented Discourse Representation Theory (SDRT. One of the information sources identified by the SDRT framework to infer the Elaboration relation is based on the existence of a potential subsumption link between the eventualities at stake, depending on lexical semantics and world knowledge. We investigate this claim by combining a weak syntactic marker of the Elaboration relation, namely the gerund clause, with lexical cohesion cues. We aim at automatically identifying gerund clauses which are Elaborations by finding cohesive links between the host main clause and the gerund clause. This approach makes it possible to accurately detect few cases of intra-sentential Elaborations in our corpus, confirming the fact that lexical cohesion cues are relevant for this task.Dans cet article, nous nous focalisons sur la relation d’Élaboration en français, telle qu’elle est décrite dans le modèle théorique de la SDRT (Segmented Discourse Representation Theory, et sur son identification automatique. Selon la SDRT, une des sources d’information permettant d’inférer la relation d’Élaboration est basée sur l’existence d’un lien de subsomption entre les types des éventualités des segments à relier, indiquant que le type de la seconde éventualité est un sous-type de celui de la première dans la sémantique lexicale des éventualités ou grâce à des connaissances du monde. Nous proposons de contribuer à cette question en combinant un indice de la relation d’Élaboration, i. e. la construction syntaxique du gérondif, et des indices de cohésion lexicale. Notre objectif est d’identifier automatiquement des propositions gérondives qui sont des Élaborations en repérant des indices de cohésion lexicale entre la proposition principale et la proposition gérondive. Cette approche permet de d

  16. Moulding Interpersonal Relations through Conditional Clauses: Consensus-Building Strategies in Written Academic Discourse

    Science.gov (United States)

    Warchal, Krystyna

    2010-01-01

    This paper focuses on the interpersonal potential of the conditional clause as a rhetorical device for establishing a dialogue between the author and the reader of an academic text in search for shared understanding and consensus. It presents a corpus-based analysis of functions conditional clauses play in linguistics research articles in an…

  17. Rahft: A Tool for Verifying Horn Clauses Using Abstract Interpretation and Finite Tree Automata

    DEFF Research Database (Denmark)

    Kafle, Bishoksan; Gallagher, John Patrick; Morales, José F.

    2016-01-01

    We present Rahft (Refinement of Abstraction in Horn clauses using Finite Tree automata), an abstraction refinement tool for verifying safety properties of programs expressed as Horn clauses. The paper describes the architecture, strength and weakness, implementation and usage aspects of the tool...

  18. 48 CFR 339.201-70 - Required provision and contract clause.

    Science.gov (United States)

    2010-10-01

    ... contract clause. 339.201-70 Section 339.201-70 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES SPECIAL CATEGORIES OF CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Electronic and Information Technology 339.201-70 Required provision and contract clause. (a) The Contracting Officer shall insert...

  19. 48 CFR 639.107-70 - DOSAR solicitation provision and contract clause.

    Science.gov (United States)

    2010-10-01

    ... provision and contract clause. 639.107-70 Section 639.107-70 Federal Acquisition Regulations System...-70 DOSAR solicitation provision and contract clause. (a) The contracting officer shall insert the... electronic access to Department information that directly supports the mission of the Department. (b)...

  20. Processing of Relative Clauses is Made Easier by Frequency of Occurrence

    Science.gov (United States)

    Reali, Florencia; Christiansen, Morten H.

    2007-01-01

    We conducted a large-scale corpus analysis indicating that pronominal object relative clauses are significantly more frequent than pronominal subject relative clauses when the embedded pronoun is personal. This difference was reversed when impersonal pronouns constituted the embedded noun phrase. This pattern of distribution provides a suitable…

  1. An Improved Separation of Regular Resolution from Pool Resolution and Clause Learning

    CERN Document Server

    Bonet, Maria Luisa

    2012-01-01

    We prove that the graph tautology principles of Alekhnovich, Johannsen, Pitassi and Urquhart have polynomial size pool resolution refutations that use only input lemmas as learned clauses and without degenerate resolution inferences. We also prove that these graph tautology principles can be refuted by polynomial size DPLL proofs with clause learning, even when restricted to greedy DPLL search.

  2. SHORT CONSIDERATIONS ABOUT THE PRECIPUT CLAUSE IN RELATION TO MATRIMONIAL CONVENTIONS

    Directory of Open Access Journals (Sweden)

    Gabriela FIERBINŢEANU

    2015-07-01

    Full Text Available The preciput clause is a subject of dispute since the new Civil Code entered into force.Several question arise in this field: is this clause a liberality or a donation, which matrimonial regime is compatible with the preciput clause, for what reason the legislature choose to regulate preciput as a clause and not as an agreement and the expressed doubts can be continued as regard to the new civil law.The authors of this article are not having in mind to put an end to all those debates they are just proposing an investigation of the preciput clause under two aspects:legal nature and aplicability as related to the matrimonial regimes – legal community, separation of assets and conventional community with accents on the normative evolution as a result of social and economic changes.

  3. A Fast Attack Algorithm on the MD5 Hash Function

    Institute of Scientific and Technical Information of China (English)

    WANG Zhang-yi; ZHANG Huan-guo; QIN Zhong-ping; MENG Qing-shu

    2006-01-01

    The sufficient conditions for keeping desired differential path of MD5 was discussed. By analyzing the expanding of subtraction difference, differential characters of Boolean functions, and the differential characters of shift rotation, the sufficient conditions for keeping desired differential path could be obtained. From the differential characters of shift rotation, the lacked sufficient conditions were found. Then an algorithm that reduces the number of trials for finding collisions were presented. By restricting search space, search operation can be reduced tc 234 for the first block and 230 for the second block. The whole attack on the MD5 can be accomplished within 2C hours using a PC with 1.6 G CPU.

  4. MD210 Note: Creation of Hollow Bunches in the PSB

    CERN Document Server

    Oeftiger, Adrian; Findlay, Alan James; Hancock, Steven; Rumolo, Giovanni; CERN. Geneva. ATS Department

    2016-01-01

    MD210 aims for the creation of longitudinally hollow bunches in the CERN PS Booster. The first three sessions have been carried out using the radial loop feedback system in order to drive the beam on a dipolar parametric resonance (instead of the phase loop). It has been found that the damping by the phase loop inhibits the excitation of the resonance to a major extent. The hollow distributions generated under these circumstances fail to reach a satisfying bunching factor. Nonetheless, proving the principally successful application of this technique to the PS Booster promises good results once the phase loop system supports trim functions. The approach, actions and detailed results of the first three MD sessions are presented in this paper.

  5. MD 382: Beam Transfer Function and diffusion mechanisms

    CERN Document Server

    Tambasco, Claudia; Buffat, Xavier; Crouch, Matthew; Pieloni, Tatiana; Boccardi, Andrea; Fuchsberger, Kajetan; Gasior, Marek; Kotzian, Gerd; Lefevre, Thibaut; Pojer, Mirko; Salvachua Ferrando, Belen Maria; Solfaroli Camillocci, Matteo; Giachino, Rossano; CERN. Geneva. ATS Department

    2016-01-01

    The Beam Transfer Function (BTF) measurements have been previously tested in the LHC during MD block 1 and 2. Different machine configurations (i.e. energy, beam intensity, emittance etc...) have been tested to determine a safe set-up (excitation amplitude) of the system to be completely transparent to the beam (no emittance blow-up neither losses). The aim of this experiment in MD block 3 was to characterize the Stability Diagram (SD) in the presence of diffusion mechanisms induced by excited resonances due to beam-beam long range and Landau octupole interplay. During the experiment, BTF measurements have been acquired at flat top for different settings of Landau octupole current, different chromaticity values and transverse feedback gains. In this note the description of the experiment is presented together with some preliminary results.

  6. Understanding of subordinate clauses in the language of dysphasic children

    Directory of Open Access Journals (Sweden)

    Lazarević Emilija

    2007-01-01

    Full Text Available This paper presents the results of the research of peculiarities of syntactic development, as an element of language structure on the grammatical level of children suffering from developmental dysphasia, after the completed speech pathology treatment of many years. Syntactic level at younger school age was studied by assessing language competence in the accomplishment of communicative sentence with subordinate clause. The research was performed on the samples of children at school age in regular primary schools in Belgrade. The sample comprised 160 respondents who were divided in two groups: target and comparative. The target group consisted of 60 respondents (children suffering from developmental dysphasia after the completed speech pathology treatment of many years, and the comparative group consisted of 100 respondents from regular primary school "Gavrilo Princip" in Zemun. Research results show that grammatical development of children suffering from developmental dysphasia takes place at a considerably slower rate and entails substantially more difficulties in accomplishing predication in subordinate clauses. This paper discusses the consequences which the difficulties in grammatical development can have on school achievement.

  7. Visual salience modulates structure choice in relative clause production.

    Science.gov (United States)

    Montag, Jessica L; MacDonald, Maryellen C

    2014-06-01

    The role of visual salience on utterance form was investigated in a picture description study. Participants heard spoken questions about animate or inanimate entities in a picture and produced a relative clause in response. Visual properties of the scenes affected production choices such that less salient inanimate entities tended to yield longer initiation latencies and to be described with passive relative clauses more than visually salient inanimates. We suggest that the participants' question-answering task can change as a function of visual salience of entities in the picture. Less salient entities require a longer visual search of the scene, which causes the speaker to notice or attend more to the non-target competitors in the picture. As a result, it becomes more important in answering the question for the speaker to contrast the target item with a salient competitor. This effect is different from other effects of visual salience, which tend to find that more salient entities take more prominent grammatical roles in the sentence. We interpret this discrepancy as evidence that visual salience does not have a single effect on sentence production, but rather its effect is modulated by task and linguistic context.

  8. WH-extractions and relative clauses in Brazilian Portuguese

    Directory of Open Access Journals (Sweden)

    NEGRÃO Esmeralda Vailati

    2000-01-01

    Full Text Available This paper aims to describe and explain WH-extraction patterns out of island contexts in Brazilian Portuguese (BP, by means of the principles established by Generative Theory. I claim that BP uses a strategy for the extraction of subjects which involves a special case of Agreement. Extractions out of relative islands are possible when the extracted WH-phrase ends up in the specifier position of the higher CP and from there it behaves as the subject of the predication. The subject-predicate relationship established under agreement makes Comp a proper governor for traces in subject position under its scope. The analysis proposed makes a distinction between two processes of relative clause formation. One in which que is an operator that transforms sentences into predicates and sits in the Comp position of a CP whose specifier can be occupied by a QP functioning as the subject of the predication. The other, in which que is a WH-word, traditionally treated as a pronoun, occupying the specifier position of a QP and introducing relative clauses as we know them.

  9. Cause Clue Clauses: Error Localization using Maximum Satisfiability

    CERN Document Server

    Jose, Manu

    2010-01-01

    Much effort is spent everyday by programmers trying to reduce long, failing execution traces to the cause of the error. We present a new algorithm for error cause localization based on a reduction to the maximal satisfiability problem (MAX SAT), which asks what is the maximum number of clauses of a Boolean formula that can be satisfied by an assignment. At an intuitive level, our algorithm takes as input a program and a failing test, and comprises the following three steps. First, as in symbolic execution, we encode a trace of a program as a Boolean trace formula which is satisfiable iff the trace is feasible. Second, for a failing program execution (e.g., one that violates an assertion or a post condition), we construct an unsatisfiable formula by taking the trace formula and additionally asserting that the input is the failing test and that the post-condition holds. Third, using MAX-SAT, we find a maximal set of clauses in this formula that can be satisfied together, and output the complement set as a poten...

  10. Analytical applications of MD-FIA-optical detection systems

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A brief introduction of recent research works in our laboratory concerning microdialysis(MD) based on optical detection combined with FIA is made in this mini-review. A biosensor system has been designed and realized the real time in vivo monitoring of some important clinic substances such as calcium, uric acid. The system has also been used to study the in vitro binding of drug-protein.

  11. A Secure Hash Function MD-192 With Modified Message Expansion

    OpenAIRE

    Harshvardhan Tiwari; Dr. Krishna Asawa

    2010-01-01

    Cryptographic hash functions play a central role in cryptography. Hash functions were introduced in cryptology to provide message integrity and authentication. MD5, SHA1 and RIPEMD are among the most commonly used message digest algorithm. Recently proposed attacks on well known and widely used hash functions motivate a design of new stronger hash function. In this paper a new approach is presented that produces 192 bit message digest and uses a modified message expansion mechanism which gene...

  12. MD 346: Summary of single bunch instability threshold measurements

    CERN Document Server

    Carver, Lee Robert; Metral, Elias; Salvant, Benoit; Levens, Tom; Buffat, Xavier; Pieloni, Tatiana; Tambasco, Claudia; Trad, Georges; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the octupole current threshold to reach single-bunch stability in the LHC at flat top. Two bunches with dierent emittances are injected in the LHC in both B1 and B2 and the current in the Landau octupoles was progressively decreased until an instability developed. The measurements provide insight into the LHC impedance model by comparing them with the stabilizing octupole current predicted from DELPHI.

  13. Application of MD Simulations to Predict Membrane Properties of MOFs

    OpenAIRE

    Elda Adatoz; Seda Keskin

    2015-01-01

    Research Article Application of MD Simulations to Predict Membrane Properties of MOFs Elda Adatoz and Seda Keskin Chemical and Biological Engineering, Koc University, Rumelifeneri Yolu, Sariyer, 34450 Istanbul, Turkey Correspondence should be addressed to Seda Keskin; Received 22 May 2015; Accepted 13 July 2015 Academic Editor: Yanlin Song Copyright © 2015 E. Adatoz and S. Keskin. This is an open access article distributed under the Creative Commons A...

  14. MD 349: Impedance Localization with AC-dipole

    CERN Document Server

    Biancacci, Nicolo; Metral, Elias; Salvant, Benoit; Papotti, Giulia; Persson, Tobias Hakan Bjorn; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the distribution of the transverse impedance of the LHC by observing the phase advance variation with intensity between the machine BPMs. Four injected bunches with different intensities are excited with an AC dipole and the turn by turn data is acquired from the BPM system. Through post-processing analysis the phase variation along the machine is depicted and, from this information, first conclusions of the impedance distribution can be drawn.

  15. MD 754: Instability Threshold for Train with 25ns Spacing

    CERN Document Server

    Carver, Lee Robert; Biancacci, Nicolo; Iadarola, Giovanni; Levens, Tom; Metral, Elias; Salvant, Benoit; Wang, Na; CERN. Geneva. ATS Department

    2016-01-01

    Measurements made since the beginning of run II at 6.5 TeV have shown that there is a large discrepancy in the instability thresholds between single bunches and trains of 72 bunches with 25ns spacing, whereas the same result is expect for pure impedance-induced instabilities. One possible explanation is that the presence of electron cloud is affecting the beam stability. This MD will attempt to determine if electron cloud is the dominant mechanism affecting beam stability.

  16. 48 CFR 1832.1110 - Solicitation provision and contract clauses. (NASA supplements paragraphs (a), (b), and (c)).

    Science.gov (United States)

    2010-10-01

    ... CONTRACT FINANCING Electronic Funds Transfer 1832.1110 Solicitation provision and contract clauses. (NASA... contract clauses. (NASA supplements paragraphs (a), (b), and (c)). 1832.1110 Section 1832.1110 Federal... the clause at FAR 52.232-34, Payment by Electronic Funds Transfer—Other than Central...

  17. Implementation of MD5 Fast Decryption Algorithm Based on Graphic Processing Unit%基于GPU的MD5高速解密算法的实现

    Institute of Scientific and Technical Information of China (English)

    乐德广; 常晋义; 刘祥南; 郭东辉

    2010-01-01

    MD5快速碰撞算法由于不支持逆向过程而无法在MD5密码攻击中得到实际应用.针对上述问题,通过分析基于图形处理单元(GPU)的MD5密码并行攻击算法原理,设计基于GPU的MD5高速解密算法,在此基础上实现一个MD5高速密码攻击系统.测试结果证明,该算法能有效加快MD5密码破解速度.

  18. 77 FR 7182 - Scott W. Houghton, M.D.; Decision and Order

    Science.gov (United States)

    2012-02-10

    ... practitioner who lacks .'' Roy Chi Lung, 74 FR 20346, 20347 (2009); Scott Sandarg, D.M.D., 74 FR 17528, 174529 (2009); John B. Freitas, D.O., 74 FR 17524, 17525 (2009); Roger A. Rodriguez, M.D., 70 FR 33206, 33207 (2005); Stephen J. Graham, M.D., 69 FR 11661 (2004); Dominick A. Ricci, M.D., 58 FR 51104...

  19. The Application Research of MD5 Encryption Algorithm in DCT Digital Watermarking

    Science.gov (United States)

    Xijin, Wang; Linxiu, Fan

    This article did the preliminary study of the application of algorithm for MD5 in the digital watermark. It proposed that copyright information will be encrypted using an algorithm MD5, and made rules for the second value image watermarks, through DCT algorithm that embeds an image by the carrier. The extraction algorithms can pick up the watermark and restore MD5 code.

  20. 76 FR 71369 - Robert G. Crummie, M.D.; Decision and Order

    Science.gov (United States)

    2011-11-17

    ... intend administrative agencies to perform meaningless tasks. See Layfe Robert Anthony, M.D., 67 FR 35582... authority under the laws of the state in which he does business. See Scott Sandarg, D.M.D., 74 FR 17528 (DEA 2009); David W. Wang, M.D., 72 FR 54297 (DEA 2007); Sheran Arden Yeates, M.D., 71 FR 39130 (DEA...

  1. 76 FR 45867 - Michael S. Moore, M.D.; Suspension of Registration

    Science.gov (United States)

    2011-08-01

    ....S.A. 823 and 824. \\8\\ Indeed, in Alan H. Olefsky, 57 FR 928 (1992), DEA revoked a practitioner's... purposes of the CSA. Edson W. Redard, M.D., 65 FR 30616, 30618 (2000); Stanley Alan Azen, M.D., 61 FR 57893... (1997)); Redard, 65 FR at 30618; Stanley Alan Azen, M.D., 61 FR 57893, 57895 (1996). Agency...

  2. Application of MD5 Algorithm in Database System%MD5算法在数据库系统中的应用

    Institute of Scientific and Technical Information of China (English)

    罗金涛

    2013-01-01

    数据加密是保护数据安全的重要手段,MD5是目前信息安全领域中使用比较广泛的加密算法,对MD5算法的原理进行了分析,并将MD5算法应用在数据库的登录验证过程中.

  3. The Class of 1989 and post-MD training

    Science.gov (United States)

    Ryten, E; Thurber, A D; Buske, L

    1998-01-01

    BACKGROUND: "The Class of 1989" is a longitudinal study of 1722 people who were awarded an MD degree by a Canadian university in 1989. This paper reports on the details of their post-MD training up to spring 1996. METHODS: Several medical professional and educational associations in Canada and the United States provided year-by-year information on field and location of post-MD training, certification achieved, whether in practice and location of practice through to spring 1996. Information from all sources was linked to a list of 1989 medical school graduates. RESULTS: Of the 1722 graduates 57 (3.3%) never entered post-MD training in Canada; 147 (8.5%) did 1 or more years of training in the United States. A total of 222 graduates (12.9%) took a break of at least 1 year from training, and 301 (17.5%) changed their choice of field or specialty after starting training. Substantial numbers took 1 or more years longer to complete training than would be expected based on the prescribed length of the training program chosen. The field or specialty choices of the cohort produced a generalist:specialist ratio of 58:42. The final numbers in several fields depended heavily on trainees changing their initial career choice. INTERPRETATION: The data point out widely differing and often very long lead times from start to completion of training. Since 1993, changes to licensure requirements have reduced opportunities for recent graduating cohorts to delay final career choices, take a break in training, prolong training or change initial career choices. Rigidities in the post-1993 training environment point to the emergence of a number of serious problems, such as dissatisfaction and high anxiety levels among residents, licensing authorities being faced with people who have not completed a training program to certification, and insufficient provision of positions for post-MD training because of underestimates of the time needed to complete training programs. The insights gained

  4. MD5算法在用户口令认证中的应用%The Application of MD5 Algorithm in The User Password Authentication

    Institute of Scientific and Technical Information of China (English)

    刘洪民; 印帮辉

    2014-01-01

    MD5算法是目前比较安全且易用的加密算法,其在密码领域有着举足轻重的地位.本文通过介绍MD5算法的特点及加密原理,分析了MD5算法在用户口令认证中的安全隐患,给出了用户口令认证应用中如何提高MD5算法安全性的措施和方法.

  5. Application of MD5 Encryption Algorithm Based on C# Technology%基于C#技术的MD5加密算法的应用

    Institute of Scientific and Technical Information of China (English)

    王倩丽

    2010-01-01

    在对Message-Digest Algorithm 5进行简要描述的同时,对MD5算法的原理作深入分析.运用MD5算法,采用目前流行的C#语言进行了具体研究,设计了MD5加密演示系统,经过测试该系统可以准确实现数据的MD5加密.

  6. SECURITY ANALYSIS ON MD5 AND ITS APPLICATION%MD5安全性分析及其应用

    Institute of Scientific and Technical Information of China (English)

    谭剑鸣; 徐建华; 汪崇华

    2002-01-01

    本文详细论述了MD5报文分解函数对文件签名的工作原理,剖析了MD5的安全性,针对具体的应用提出了使用MD5与RSA结合来解决数字签名的完整方案.文章的最后对MD5在PGP数字签名中的具体应用进行了分析讨论.

  7. Design and Implementation of MD5 with Salt%一种带随机数MD5算法的设计与实现

    Institute of Scientific and Technical Information of China (English)

    张丽香

    2013-01-01

    随着网络的迅速普及,信息加密技术的发展对保障网络安全有着重大的作用与意义.MD5是HASH算法,常用来对重要数据的进行存储,本文对MD5算法进行了简要描述,介绍了MD5的破解方式,并对带随机数MD5算法进行了描述,采用PHP对算法的使用进行实现.

  8. Nano-scratch study of molecular deposition (MD) films on silicon wafer using nanoindentation~1

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Experiment of the molecular deposition (MD) films with and without alkyl terminal de-posited on the silicon wafer were conducted by using nanoindentation. It was found that MD filmsand alkyl terminated MD films exhibit higher critical load (scratch resistance or adhesive strength)and lower coefficient of friction compared with the silicon substrate. Critical load (scratch resis-tance) increases with the number of layers, and coefficients of friction of those MD film with alkylterminal are still best for the same layer of MD film.

  9. 改进MD5码增强网站密码安全性

    Institute of Scientific and Technical Information of China (English)

    张越; 陈跃; 刘林飞

    2009-01-01

    目的探讨改进MD5码,增强网络安全性.方法采用对用户密码进行加长、加强的二次加密,并对MD5码的算法进行修改,再使用MD5二次加密或多次加密.结果通过改进MD5码,用户密码安全性明显增强.结论改进MD5码,可以提高网站安全性.

  10. THE ROLE OF THE GRAMMAR ON PORTUGUESE TEXTBOOKS: A LOOK ON TEACHING OF RELATIVE CLAUSE

    Directory of Open Access Journals (Sweden)

    Aliana Lopes CÂMARA

    2014-12-01

    Full Text Available This paper studies how the textbooks of Portuguese Language of Secondary School, approved by the Programa Nacional do Livro Didático-2014, approach the teaching of grammar, in particular as regards the treatment of the relative subordinate clause. For this, first we start with the comparison between the proposals manuals for teaching grammar and what was accomplished in the student book. Furthermore, we propose here an interface between the results of the analysis of textbooks and functional description of the relative clause. In other words, we try to verify as some descriptive aspects can be used in the teaching of relative clause, with the aim of developing reading and writing skills. In order to do that, we take as theoretical framework the different conceptions of grammar proposed in Travaglia (2009, 2011 and Functional Discourse Grammar (HENGEVELD; MACKENZIE, 2008. This research points to the need to emphasize the cohesive role established by the relative pronoun that introduces the relative clause, to understand the non-restrictive relative clause from its argumentative function and to review the distinction between subtypes of adjective clause from the criteria of omission of the subordinate clause.

  11. Analysis and Transformation Tools for Constrained Horn Clause Verification

    DEFF Research Database (Denmark)

    Kafle, Bishoksan; Gallagher, John Patrick

    2014-01-01

    is to investigate the use of a combination of off-the-shelf techniques from the literature in analysis and transformation of Constraint Logic Programs (CLPs) to solve challenging CHC verification problems. We find that many problems can be solved using a combination of tools based on well-known techniques from......Several techniques and tools have been developed for verification of properties expressed as Horn clauses with constraints over a background theory (CHC). Current CHC verification tools implement intricate algorithms and are often limited to certain subclasses of CHC problems. Our aim in this work...... abstract interpretation, semantics-preserving transformations, program specialisation and query-answer transformations. This gives insights into the design of automatic, more general CHC verification tools based on a library of components....

  12. Pharmacist conscience clauses and access to oral contraceptives.

    Science.gov (United States)

    Flynn, D P

    2008-07-01

    The introduction of conscience clauses after the 1973 US Supreme Court decision in Roe v. Wade allowed physicians and nurses to opt out of medical procedures, particularly abortions, to which they were morally opposed. In recent years pharmacists have requested the same consideration with regard to dispensing some medicines. This paper examines the pharmacists' role and their professional and moral obligations to patients in the light of recent refusals by pharmacists to dispense oral contraceptives. A review of John Rawls's concepts of the "original position" and the "veil of ignorance", along with consideration of the concept of compartmentalisation, are used to assess pharmacists' requests and the moral and legal rights of patients to have their prescriptive needs met.

  13. Preparation and Properties of A Novel Modified Mannich Amine as Waterborne Epoxy Curing Agent%改性曼尼希胺水性环氧固化剂的制备及性能

    Institute of Scientific and Technical Information of China (English)

    李楚新; 段颖; 丁嘉欣; 夏新年

    2012-01-01

    A novel Modified Mannich Amine ( MAI ) was synthesized by amine exchange reaction using polyether amine (D -230) and DMP -30 as raw materials. A liquid epoxy resin (EP) and a homemade mono -functional epoxy polymer (PEG - EP) were used as chain extender for MAl's chain extension modifica tion, which was then terminated with phenyl glycidyl ether(PGE) to get Modified Mannich Amine(MA3). Finally, the Mannich amine waterborne epoxy curing agents ( CAs) were produced by phase - inversion e- mulsification method and used for waterborne epoxy resin. The influences of the PEG - EP amount, the feed ing ratio of MA1/EP and MAI/PEG on the stability of the dispersion were studied. The chemical structures and properties of the cured films were studied by physical chemistry method. The cured films of an optimiza tion system showed a hardness 229 s, flexibility 1 mm, adhesion 0 grade, pot ?life 5 h, and excellent water resistance.%以聚醚胺(D - 230)和DMP - 30为原料,利用胺交换反应制得一种新型的改性曼尼希胺(MAI).然后以自制的端官能环氧聚合物( PEG - EP)与低相对分子质量液体环氧树脂(EP)为扩链剂对MAI进行扩链改性,并用苯基缩水甘油醚(PGE)封端,最后采用相反转法制得了一种新型的改性曼尼希水性环氧固化剂.讨论了PEG - EP的添加量、MAI与EP的加料比及封端剂的添加量对水性固化剂体系稳定性的影响.并采用物理化学方法对反应程度及涂膜的性能进能了表征分析.优化体系固化涂膜硬度229s,柔韧性1mm,附着力0级,适用期5h,耐水性优异.

  14. Role of toluene in hydrogen sulfide combustion under Claus condition

    International Nuclear Information System (INIS)

    Highlights: • Examined the role of toluene addition in hydrogen sulfide combustion. • Effect of 0%, 0.5%, 1% and 5% of toluene in H2S gas stream was examined. • Toluene addition triggers production of H2 which provides oxidation competition to H2S. • Increased amount of toluene in H2S gas reduced SO2 and increased asymptotic value of H2S. • Toluene addition enhanced the formation of CO and COS. - Abstract: Experimental investigations on the effect of different amounts of toluene addition to H2S combustion in oxygen under Claus condition (Φ = 3) are presented. Three toluene concentrations of 0.5%, 1% and 5% in H2S are presented and compared with the baseline case of 100% H2S oxygen combustion. Temperature data showed that addition of toluene to H2S gas stream increases the flame temperature because of large heating value associated with toluene. Addition of toluene resulted in the production of H2, which increased with increase in the amounts of toluene addition. Furthermore, increased addition of toluene concentration increased the asymptotic minimum value of hydrogen sulfide due to oxidation competition between the formed H2 and H2S. The results also showed that the presence of CO triggers the formation of COS with toluene addition due to reaction of CO with SO2. The results showed that SO2 mole fraction increased to a maximum value then decayed with distance along the reactor. Addition of toluene increased the rate of SO2 decay. These results have direct impact on sulfur capture in the Claus reactor and its performance

  15. Subject of Subordinate Clause as Object with Verbs of Perception, Thought, and Communication in Old Russian

    Directory of Open Access Journals (Sweden)

    Anna A. Pichkhadze

    2012-08-01

    Full Text Available This paper describes the Old Russian construction involving verbs of perception, thought, and communication. In this construction, a single semantic argument corresponds to two syntactic constituents: a direct object and a finite subordinate clause, the subject of which is coreferential with the direct object of the main clause. The Old Russian construction is seen as an instantiation of a cross-linguistic option in the argument structure of these verbs (above all, of the perception verbs, that is, to take the subject of the subordinate clause as the direct object.

  16. A Secure Hash Function MD-192 With Modified Message Expansion

    CERN Document Server

    Tiwari, Harshvardhan

    2010-01-01

    Cryptographic hash functions play a central role in cryptography. Hash functions were introduced in cryptology to provide message integrity and authentication. MD5, SHA1 and RIPEMD are among the most commonly used message digest algorithm. Recently proposed attacks on well known and widely used hash functions motivate a design of new stronger hash function. In this paper a new approach is presented that produces 192 bit message digest and uses a modified message expansion mechanism which generates more bit difference in each working variable to make the algorithm more secure. This hash function is collision resistant and assures a good compression and preimage resistance.

  17. A Secure Hash Function MD-192 With Modified Message Expansion

    Directory of Open Access Journals (Sweden)

    Harshvardhan Tiwari

    2010-02-01

    Full Text Available Cryptographic hash functions play a central role in cryptography. Hash functions were introduced in cryptology to provide message integrity and authentication. MD5, SHA1 and RIPEMD are among the most commonly used message digest algorithm. Recently proposed attacks on well known and widely used hash functions motivate a design of new stronger hash function. In this paper a new approach is presented that produces 192 bit message digest and uses a modified message expansion mechanism which generates more bit difference in each working variable to make the algorithm more secure. This hash function is collision resistant and assures a good compression and preimage resistance.

  18. StandsSIM-MD: a Management Driven forest SIMulator

    Directory of Open Access Journals (Sweden)

    Susana Barreiro

    2016-07-01

    Full Text Available Aim of the study: The existing stand level forest simulators available in Portugal were not developed with the aim of including up-to-date model versions and were limited in terms of accounting for forest management. The simulators’ platform, sIMfLOR was recently created to implement different growth models with a common philosophy. The objective was developing one easily-updatable, user-friendly, forest management and climate change sensitive simulator capable of projecting growth for the main tree species in Portugal. Area of the study: Portugal. Material and methods: The new simulator was programmed in a modular form consisting of several modules. The growth module integrates different forest growth and yield models (empirical and process-based for the main wood production tree species in Portugal (eucalypt, umbrella and maritime pines; whereas the management module drives the growth projections along the planning horizon according to a range of forest management approaches and climate (at present only available for eucalypt. Main results: The main result is the StandsSIM-MD Management Driven simulator that overcomes the limitations of the existing stand level simulators. It is a step forward when compared to the models currently available in the sIMfLOR platform covering more tree species, stand structures and stand compositions. It is focused on end-users and it is based on similar concepts regarding the generation of required inputs and generated outputs. Research highlights: -          Forest Management Driven simulations approach -          Multiple Prescriptions-Per-Stand functionality -          StandsSIM-MD can be used to support landowners decisions on stand forest management -          StandsSIM-MD simulations at regional level can be combined with optimization routines Keywords: Forest simulator, Forest Management Approaches; StandsSIM-MD; forest management.

  19. 散列算法MD5和SHA-1的比较%Comparison between MD5 and SHA-1

    Institute of Scientific and Technical Information of China (English)

    王泽; 曹莉莎

    2016-01-01

    MD5 and SHA-1 are the two known Hash Algorithm which are widely applied in information security, they are both developed from MD4.This paper introduces their algorithm logic in detail, compares them though simulation experiment ,soft-ware testing, etc. Finally, it draw a conclusion:The SHA-1 algorithm is more secure than the MD5 algorithm, but in the same hardware, SHA-1 is slower than MD5.%MD5和SHA-1是两个已知的广泛应用于信息安全的散列算法,均由MD4发展而来。详细介绍了它们的算法逻辑,并通过模拟实验、软件测试等方式对其在各个方面进行比较,最终得出结论:SHA-1算法比MD5算法的安全性更高,但在同一硬件上,SHA-1比MD5运行的要慢。

  20. Reverse Crack of MD5 Encryption and Its Safety Improvement%MD5加密逆向破解及安全性改进

    Institute of Scientific and Technical Information of China (English)

    王雄; 朱志祥; 许辉辉

    2014-01-01

    针对消息摘要算法第五版(Message-Digest Algorithm 5,MD5)不可逆的特性,通过组建Oracle明文数据库、调用MD5函数,建立明文与MD5码之间的一一对应关系,实现了对MD5加密的逆向破解.从应对碰撞攻击和反向查询两方面,总结多种改进措施,提高了MD5加密算法在实际应用中的安全性.

  1. MD5加密算法的研究及应用%Research and application of MD5 encryption algorithm

    Institute of Scientific and Technical Information of China (English)

    魏晓玲

    2010-01-01

    针对当前网站建设和系统开发中用户信息等重要数据的安全问题,提出了一种MD5加密算法,可以对用户密码进行加密.MD5加密算法是一种比较常用的单向加密算法,通过对该算法的深入研究,介绍了MD5算法的特性、算法原理及其算法流程,并给出MD5算法在一个具体系统中的实际应用,得出MD5算法是一种非常安全和易用的加密算法.

  2. Novel zinc(II) and copper(II) complexes of a Mannich base derived from lawsone: Synthesis, single crystal X-ray analysis, ab initio density functional theory calculations and vibrational analysis.

    Science.gov (United States)

    Neves, Amanda P; Vargas, Maria D; Téllez Soto, Claudio A; Ramos, Joanna M; Visentin, Lorenzo do C; Pinheiro, Carlos B; Mangrich, Antônio S; de Rezende, Edivaltrys I P

    2012-08-01

    Zinc(II) and copper(II) complexes of a tridentate Mannich base L1 derived from 2-hydroxy-1,4-naphthoquinone, pyridinecarboxyaldehyde and 2-aminomethylpyridine, [ZnL1Cl(2)]·H(2)O 1 and [CuL1Cl(2)]·2H(2)O 2, have been synthesized and fully characterized. The structure of complex 1 has been elucidated by a single crystal X-ray diffraction study: the zinc atom is pentacoordinate and the coordination geometry is a distorted square base pyramid, with a geometric structural parameter τ equal to 0.149. Vibrational spectroscopy and ab initio DFT calculations of both compounds have confirmed that the two complexes exhibit similar structures. Full assignment of the vibrational spectra was also supported by careful analysis of the distorted geometries generated by the normal modes. PMID:22513170

  3. Design, synthesis and preliminary structure-activity relationship investigation of nitrogen-containing chalcone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors: a further study based on Flavokawain B Mannich base derivatives.

    Science.gov (United States)

    Liu, Haoran; Fan, Haoqun; Gao, Xiaohui; Huang, Xueqing; Liu, Xianjun; Liu, Linbo; Zhou, Chao; Tang, Jingjing; Wang, Qiuan; Liu, Wukun

    2016-08-01

    In order to study the structure-activity relationship of Flavokawain B Mannich-based derivatives as acetylcholinesterase (AChE) inhibitors in our recent investigation, 20 new nitrogen-containing chalcone derivatives (4 a-8d) were designed, synthesized, and evaluated for AChE inhibitory activity in vitro. The results suggested that amino alkyl side chain of chalcone dramatically influenced the inhibitory activity against AChE. Among them, compound 6c revealed the strongest AChE inhibitory activity (IC50 value: 0.85 μmol/L) and the highest selectivity against AChE over BuChE (ratio: 35.79). Enzyme kinetic study showed that the inhibition mechanism of compound 6c against AChE was a mixed-type inhibition. The molecular docking assay showed that this compound can both bind with the catalytic site and the peripheral site of AChE. PMID:26186269

  4. 75 FR 32642 - Defense Federal Acquisition Regulation Supplement; Ground and Flight Risk Clause (DFARS Case 2007...

    Science.gov (United States)

    2010-06-08

    ... 72 FR 69177 on December 7, 2007. This final rule revises and combines the two clauses into a single... include ``hush houses,'' test hangars and comparable structures, and other designated areas....

  5. 77 FR 66466 - General Services Administration Regulation; Information Collection; Packing List Clause

    Science.gov (United States)

    2012-11-05

    ... From the Federal Register Online via the Government Publishing Office GENERAL SERVICES ADMINISTRATION General Services Administration Regulation; Information Collection; Packing List Clause AGENCY... information collection documents from the General Services Administration, Regulatory Secretariat (MVCB),...

  6. Labor clauses in regional trade agreements and effects on labor conditions : an empirical analysis

    OpenAIRE

    KAMATA Isao; 鎌田, 伊佐生

    2016-01-01

    An increasing number of bilateral or plurilateral trade agreements (or regional trade agreements: RTAs) include "labor clauses" that require or urge the signatory countries to commit to maintaining a certain level of labor standards. This paper performs an empirical analysis of the impacts of such labor clauses provided in RTAs on working conditions that laborers in the RTA signatory countries actually face, using macro-level data for a wide variety of countries. The paper first examines the ...

  7. 12 CFR 591.5 - Limitation on exercise of due-on-sale clauses.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Limitation on exercise of due-on-sale clauses. 591.5 Section 591.5 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY PREEMPTION OF STATE DUE-ON-SALE LAWS § 591.5 Limitation on exercise of due-on-sale clauses. (a) General. Except as provided in § 591.4 (c) and (d)(4)...

  8. Considerations concerning the criminal clause, expression of contractual principle and law abuse

    OpenAIRE

    Nora Andreea Daghie

    2009-01-01

    The criminal clause is an accessory convention through which the parts evaluate in advance the prejudiceinterestswhich come from the inexecution lato sensu of the contractual obligations. This convention named criminalclause is the expression of the contractual liberty principle and presents a singular practical utility but also someinconveniences. Thus the criminal clause allows avoiding the difficulties of judicial evaluation of prejudices-interests.In this way, the creditor is not obliged ...

  9. [Professor Frantisek Por MD and Professor Robert Klopstock MD, students at Budapest and Prague Faculties of Medicine].

    Science.gov (United States)

    Mydlík, M; Derzsiová, K

    2010-11-01

    Professor Frantisek Por MD and Professor Robert Klopstock MD were contemporaries, both born in 1899, one in Zvolen, the other in Dombovar, at the time of Austro-Hungarian Monarchy. Prof. Por attended the Faculty of Medicine in Budapest from 1918 to 1920, and Prof. Klopstock studied at the same place between 1917 and 1919. From 1920 until graduation on 6th February 1926, Prof. Por continued his studies at the German Faculty of Medicine, Charles University in Prague. Prof. Klopstock had to interrupt his studies in Budapest due to pulmonary tuberculosis; he received treatment at Tatranske Matliare where he befriended Franz Kafka. Later, upon Kafka's encouragement, he changed institutions and continued his studies at the German Faculty of Medicine, Charles University in Prague, where he graduated the first great go. It is very likely that, during their studies in Budapest and Prague, both professors met repeatedly, even though their life paths later separated. Following his graduation, Prof. Por practiced as an internist in Prague, later in Slovakia, and from 1945 in Kosice. In 1961, he was awarded the title of university professor of internal medicine at the Faculty of Medicine, Pavol Jozef Safarik University in Kosice, where he practiced until his death in 1980. Prof. Klopstock continued his studies in Kiel and Berlin. After his graduation in 1933, he practiced in Berlin as a surgeon and in 1938 left for USA. In 1962, he was awarded the title of university professor of pulmonary surgery in NewYork, where he died in 1972.

  10. 基于简化MD5的TFIDF算法%TFIDF Algorithm Based on a Simplified MD5

    Institute of Scientific and Technical Information of China (English)

    刘雅正; 陈受凯; 唐向阳

    2012-01-01

    随着信息技术不断的发展,海量数据的处理效率成为不可逃避的问题.传统的网页分类算法在分类效果上已经相对成熟,所以在这样的背景下从传统网页分类算法中特征值权重算法的效率和代价出发,分析并提出了基于简化MD5的特征值权重算法.有效减少了特征值提取时的比对和最后一次排序的效率,从而提高了整个网页分类的效率.%With the rapid development of information technology, the process efficiency of massive data has become inescapable problem and Web page classification algorithm has matured yet, so from the efficiency and cost of eigenvalue weights algorithm in traditional web page classification algorithm is started. Eigenvalue weights algorithm based on a simplified MD5, and effective in reducing the efficiency of eigenvalue extraction time and the last sort of eigenvalue are analyzed and proposed. Improving the efficiency of the whole Web page classification is presented.

  11. The improvement of cryptography MD5 algorithm%密码学中信息摘要算法MD5的改进

    Institute of Scientific and Technical Information of China (English)

    林平

    2011-01-01

    MD5算法的基础上,针对MD5算法密文是一个32位16进制字符来表示值的特征,提出MD5改进算法,首先采用替换加密算法Md5Replace加密MD5算法密文,隐藏MD5算法密文的特征;再选定替换加密密文中某一位置插入由随机函数算法Md5Random产生定长的字符串得到最后的密文,改变了替换加密密文位数,隐藏了替换加密算法替换规律.在不改变算法效率的前提下,提高算法安全强度.

  12. MD5碰撞攻击的差分路径构建%Constructing Differential Path in MD5 Collision Attack

    Institute of Scientific and Technical Information of China (English)

    刘凡保; 谢涛

    2009-01-01

    著名的杂凑算法MD5是MD4的增强版本,由Ronald L.Rivest在1991年设计.MD5广泛应用于口令变换、数据完整性、数字证书等领域.近年最具影响的MD5安全性的分析结果是王小云首次发现的MD5碰撞.之后,MD5碰撞攻击的改进主要集中在提高碰撞对搜索的性能.基于新的不同于王小云的明文差分构成的MD5碰撞,介绍差分路径的构建方法,并给出一条差分路径以及碰撞对数据.

  13. 报文摘要算法MD5的分析与改进

    Institute of Scientific and Technical Information of China (English)

    汪勋亮; 赵春霞; 郭剑辉

    2014-01-01

    MD5算法在数据加密方面有着广泛的应用,但是它无法抵御查字典攻击和差分等攻击。为此本文介绍了报文算法MD5和Base64算法,以及在两种算法的基础上提出了MD5的改进算法,以应对以上被攻击的缺陷。%MD5 encryption algorithm in the data has a wide range of applications,but it can not resist dictionary attacks and differential attacks.This paper introduces the MD5 message digest algorithm and Base64 algorithm,and two algorithms based on the proposed the improved MD5 algorithm,the effect is to deal with the above attack.

  14. WEB登录系统中MD5加密算法的PHP实现%PHP Implementation of MD5 Encryption Algorithm in WEB Login System

    Institute of Scientific and Technical Information of China (English)

    王雄; 李旭辉; 许琳华

    2011-01-01

    MD5是web应用程序中常用的加密算法,很多网站的登录模块都采用了MD5加密,用户登录密码通过使用它加密存储到数据库当中,在一定程度上使入侵者不易获得用户登录权限.本文分析比较了中MD5不同的改进算法,并给出了最后的结论.

  15. The MD5 Technical Analysis and Improvement Measures%MD5技术解析及改进措施

    Institute of Scientific and Technical Information of China (English)

    窦立莉

    2010-01-01

    随着网络的迅速普及,信息加密技术的发展对保障网络安全有着重大的作用与意义.本文对MD5 这种单向加密算法进行了简要描述,对MD5 算法的原理进行了深入分析,并提出了MD5 码的多种改进措施.

  16. Fred Loe, MD, and the history of trachoma.

    Science.gov (United States)

    Feibel, Robert M

    2011-04-01

    Trachoma has been one of the most blinding diseases in the history of ophthalmology. From its initial description in antiquity until the late 1930s, no specific treatment or effective cure had been known, and the only expedient had been to destroy the diseased tissue containing the infectious agent, rendering the disease inactive. Virtually all medical, mechanical, and surgical treatments were unsatisfactory, with cure rates of approximately 20%. Therapy for trachoma had barely advanced from the measures used by the ancient Egyptian, Greek, and Roman physicians. All prior therapies became obsolete in 1938 when Fred Loe, MD, working on an American Indian reservation, introduced sulfanilamide as a treatment of trachoma, achieving a 90% cure rate. One of the most unusual aspects of Loe's career was that he had no formal training in ophthalmology and was completely self-taught as an ophthalmologist. PMID:21482877

  17. A workshop on leadership for MD/PhD students

    Directory of Open Access Journals (Sweden)

    Mark D. Cannon

    2011-08-01

    Full Text Available Success in academic medicine requires scientific and clinical aptitude and the ability to lead a team effectively. Although combined MD/PhD training programs invest considerably in the former, they often do not provide structured educational opportunities in leadership, especially as applied to investigative medicine. To fill a critical knowledge gap in physician-scientist training, the Vanderbilt Medical Scientist Training Program (MSTP developed a biennial two-day workshop in investigative leadership. MSTP students worked in partnership with content experts to develop a case-based curriculum and deliver the material. In its initial three offerings in 2006, 2008, and 2010, the workshop was judged by MSTP student attendees to be highly effective. The Vanderbilt MSTP Leadership Workshop offers a blueprint for collaborative student-faculty interactions in curriculum design and a new educational modality for physician-scientist training.

  18. Luminosity Anti-leveling with Crossing Angle (MD 1669)

    CERN Document Server

    Gorzawski, Arkadiusz; Ponce, Laurette; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; CERN. Geneva. ATS Department

    2016-01-01

    A significant fraction of the LHC luminosity ($\\sim$30\\% in 2016) is lost due to the presence (and necessity) of the crossing angles at the IPs. At the LHC the crossing angle is typically set to a value that provides sufficient separation of the beams at the start of fills for the peak bunch intensities. As the bunch intensity decays during a fill, it is possible to reduce the crossing angle and recover some luminosity. A smooth crossing angle reduction procedure must be developed to take advantage of this option during stable beam operation. During this MD a smooth procedure for luminosity leveling with crossing angle was tested. It was demonstrated that the orbit was well controlled, beam losses were low and the offset leveled experiments ALICE and LHCb were not affected by crossing angle leveling in ATLAS and CMS.

  19. QM/MM-MD simulations of conjugated polyelectrolytes

    DEFF Research Database (Denmark)

    Sjöqvist, Jonas; Linares, Mathieu; Mikkelsen, Kurt Valentin;

    2014-01-01

    A methodological development is reported for the study of luminescence properties of conjugated polyelectrolytes, encompassing systems in which dihedral rotational barriers are easily overcome at room temperature. The components of the model include (i) a molecular mechanics (MM) force field...... description of the solvent in its electronic ground state as well as the chromophore in its electronic ground and excited states, (ii) a conformational sampling by means of classical molecular dynamics (MD) in the respective electronic states, and (iii) spectral response calculations by means of the quantum....... In fluorescence spectroscopy, the experimental spectrum shows a vibrational progression that is not addressed by theory, but the theoretical band position is in excellent agreement with experiment, with a highly accurate description of the Stokes shift as a result....

  20. RADIATION PRESSURE DETECTION AND DENSITY ESTIMATE FOR 2011 MD

    Energy Technology Data Exchange (ETDEWEB)

    Micheli, Marco; Tholen, David J.; Elliott, Garrett T., E-mail: micheli@ifa.hawaii.edu, E-mail: tholen@ifa.hawaii.edu, E-mail: gte@ifa.hawaii.edu [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States)

    2014-06-10

    We present our astrometric observations of the small near-Earth object 2011 MD (H ∼ 28.0), obtained after its very close fly-by to Earth in 2011 June. Our set of observations extends the observational arc to 73 days, and, together with the published astrometry obtained around the Earth fly-by, allows a direct detection of the effect of radiation pressure on the object, with a confidence of 5σ. The detection can be used to put constraints on the density of the object, pointing to either an unexpectedly low value of ρ=(640±330)kg m{sup −3} (68% confidence interval) if we assume a typical probability distribution for the unknown albedo, or to an unusually high reflectivity of its surface. This result may have important implications both in terms of impact hazard from small objects and in light of a possible retrieval of this target.

  1. Supreme Court to hear ADA suit involving arbitration clause.

    Science.gov (United States)

    1998-03-20

    The U.S. Supreme Court agreed to review a third case under the Americans with Disabilities Act (ADA) this year. The Supreme Court previously agreed to hear [name removed] v. [Name removed], involving a dentist who refused to treat an HIV-positive patient in his office. The second case is Pennsylvania Department of Corrections v. [Name removed], in which the State asserts that the ADA does not apply to prisons. The third involves whether an arbitration clause in a labor union's collective bargaining agreement prevents a court from hearing a union member's discrimination claim. [Name removed] longshoreman [name removed] alleges that the [name removed] and several employers violated the ADA when they refused to help him for employment referral. [Name removed] previously settled a workers' compensation disability claim with [name removed] and Terminal Co., his employer. Three years later he applied for work at the International Longshoreman's Association hiring hall and was referred to four different employers. The employers discovered he had received a worker's compensation settlement and would no longer accept [name removed] for employment referral. The case is important because union members can continue to file ADA charges with the EEOC and the outcomes will vary depending on the circuit where the union member happens to file the claim. PMID:11365192

  2. Plasticity and Failure in Nanocrystalline BCC Metals via MD Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Rudd, R E

    2010-02-12

    Advances in the ability to generate extremely high pressures in dynamic experiments such as at the National Ignition Facility has motivated the need for special materials optimized for those conditions as well as ways to probe the response of these materials as they are deformed. We need to develop a much deeper understanding of the behavior of materials subjected to high pressure, especially the effect of rate at the extremely high rates encountered in those experiments. Here we use large-scale molecular dynamics (MD) simulations of the high-rate deformation of nanocrystalline tantalum at pressures less than 100 GPa to investigate the processes associated with plastic deformation for strains up to 100%. We focus on 3D polycrystalline systems with typical grain sizes of 10-20 nm. We also study a rapidly quenched liquid (amorphous solid) tantalum. We apply a constant volume (isochoric), constant temperature (isothermal) shear deformation over a range of strain rates, and compute the resulting stress-strain curves to large strains for both uniaxial and biaxial compression. We study the rate dependence and identify plastic deformation mechanisms. The identification of the mechanisms is facilitated through a novel technique that computes the local grain orientation, returning it as a quaternion for each atom. This analysis technique is robust and fast, and has been used to compute the orientations on the fly during our parallel MD simulations on supercomputers. We find both dislocation and twinning processes are important, and they interact in the weak strain hardening in these extremely fine-grained microstructures. We also present some results on void growth in nanocrystalline BCC metals under tension.

  3. MD-2 determinants of nickel and cobalt-mediated activation of human TLR4.

    Directory of Open Access Journals (Sweden)

    Alja Oblak

    Full Text Available Recent findings unexpectedly revealed that human TLR4 can be directly activated by nickel ions. This activation is due to the coordination of nickel by a cluster of histidine residues on the ectodomain of human TLR4, which is absent in most other species. We aimed to elucidate the role of MD-2 in the molecular mechanism of TLR4/MD-2 activation by nickel, as nickel binding site on TLR4 is remote from MD-2, which directly binds the endotoxin as the main pathological activator of TLR4. We identified MD-2 and TLR4 mutants which abolished TLR4/MD-2 receptor activation by endotoxin but could nevertheless be significantly activated by nickel, which acts in synergy with LPS. Human TLR4/MD-2 was also activated by cobalt ions, while copper and cadmium were toxic in the tested concentration range. Activation of TLR4 by cobalt required MD-2 and was abolished by human TLR4 mutations of histidine residues at positions 456 and 458. We demonstrated that activation of TLR4 by nickel and cobalt ions can trigger both the MyD88-dependent and the -independent pathway. Based on our results we propose that predominantly hydrophobic interactions between MD-2 and TLR4 contribute to the stabilization of the TLR4/MD-2/metal ion complex in a conformation that enables activation.

  4. Iterative redundant encryption based on MD5 algorithm%基于MD5的迭代冗余加密算法

    Institute of Scientific and Technical Information of China (English)

    王津涛; 覃尚毅; 王冬梅

    2007-01-01

    MD5报文摘要算法是一种非常流行的加密方案,是对任意长度的消息提取数字指纹或消息摘要的算法,但是,在计算上难以提供两个具有相同数字指纹的不同消息,并难以由给定的数字指纹推算出相应的消息.基于MD5的迭代冗余加密算法对MD5算法进行了扩展,利用了MD5算法的强大安全性,实现了文件加密、解密和数据完整性保护的功能.

  5. MD5算法的过程分析及其C#实现%Process Analysis of MD5 Algorithm and Its C# realization

    Institute of Scientific and Technical Information of China (English)

    杜昌钰

    2008-01-01

    文章对MD5即"Message-Digest Algorithm 5(报文流行的C#对8D5算法进行了具体的实现,给出了一个具体的C#加密实例.虽然MD5因王小云教授在2004国际密码学会议(Crypto'2004)上发表的论文受到了前所未有的冲击,但MD5在一些非关键领域应用还是相当广泛.最后还提出了一些针对MD5现状的解决对策和建议.

  6. ASP网站用户帐号的MD5加密技术%The Encryption Techniques of MD5 about User Accounts in ASP Web

    Institute of Scientific and Technical Information of China (English)

    田文艳

    2007-01-01

    本文介绍了Asp中的MD5(Message-Digest Algorithm 5)加密技术,分析了它的工作原理及使用过程,并通过具体的使用实例,说明了MD5加密技术在网站开发中的具体实现方法.

  7. Design of MD5 High-Speed Models on FPGA%基于FPGA的MD5高速处理模型设计

    Institute of Scientific and Technical Information of China (English)

    韩津生; 林家骏; 叶建武; 周文锦

    2012-01-01

    In order to improve the performance of MD5 on FPGA, the design concept based on dataflow was proposed. At the design phase, it can assess effectively the specific FPGA, the expected system performance and the specific complex algorithms. Three models of MD5 round were put forward and one of the models was chosen to do experiment. The experimental results indicate that the designed MD5 algorithm could increase efficiently the throughput up to 66. 56 Gbit/s.%为提高MD5的处理速度,提出了基于数据流的设计思想.该思想在设计阶段可以对特定的FPGA、预期的系统性能、复杂的专用算法等进行有效评估.基于该思想,提出了3种不同的MD5节点模型.通过分析,对其中1种模型进行实验,实验验证了基于数据流的设计思想能有效提高MD5的吞吐量,达到66.56 Gbit/s.

  8. 一种使MD5算法产生更强雪崩效应的方法%Generating stronger avalanche effect in MD5 algorithm

    Institute of Scientific and Technical Information of China (English)

    张鑫彦; 闫德勤

    2010-01-01

    通过研究不同的差分分析对MD5算法的攻击后发现,差分分析攻击之所以可以成功,是因为在MD5算法中改变了明文中一些特定位,而这些特定位的改变在许多轮中最多只影响链接变量的几个位,并且这些小的差分能在随后的多轮操作中得到纠正,从而产生了碰撞.这就说明原MD5算法的雪崩效应不能阻止差分分析的攻击,而为了提高MD5算法的安全性,必须提高其雪崩效应的敏感性.分析结果表明,用动态明文变化函数对MD5算法进行修改,能使其产生更敏感的雪崩效应,以此来有效防止差分分析攻击,提高MD5算法的安全性.

  9. A super-high throughput implementation of MD5 algorithm on FPGA%超高吞吐量MD5算法的FPGA实现

    Institute of Scientific and Technical Information of China (English)

    王臣; 袁焱

    2011-01-01

    In this paper, a novel architecture is proposed to increase the performance of MD5 computing in FPGA , which can achieve a super-high throughput. The scheme is based on full-pipeline for MD5 implementation. Moreover, FIFO cache structure is used for data storage and cooperative computing. The results of simulation and implementation show that the scheme can achieve the theoretical upper bound on throughput. And based on the same platform of FPGA, it outperforms the published scheme with best performance in terms of 77% higher throughput.%为了提高MD5算法在FPGA中实现的运算效率,使之达到超高的数据吞吐量,提出了一种新的全流水线架构,用于实现MD5算法.架构中使用了FIFO缓存存储数据,以配合流水线的运算.实验验证其达到了单个MD5运算单元运算吞吐量的理论上限,在相同芯片平台上,超过已发表的MD5运算模块最高吞吐量的77%.

  10. 33 CFR 110.71 - Jacobs Nose Cove, Elk River, Md.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Jacobs Nose Cove, Elk River, Md... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.71 Jacobs Nose Cove, Elk River, Md. The water area of Jacobs Nose Cove, on the west side of the mouth of Elk River, Maryland, comprising the...

  11. 75 FR 21528 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Science.gov (United States)

    2010-04-26

    ... Policies and Procedures (44 FR 11034, February 26, 1979), and 3. Will not have a significant economic... have the same design as those installed on Model MD-90-30 airplanes. Therefore, Model MD-90-30..., hangar lighting, flashlight, or ] droplight and may require removal or opening of access panels or...

  12. 75 FR 49979 - Tony T. Bui, M.D.; Revocation of Registration

    Science.gov (United States)

    2010-08-16

    ....'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003). I ``may rely on any one or a combination of factors... produced a letter from Vella V. Chancellor, M.D., the Chair of the Physician's Recovery Committee of the Dallas County Medical Society. RX 11. Dr. Chancellor wrote that Respondent ``has been actively seeing...

  13. 77 FR 67673 - Fernando Valle, M.D.; Decision and Order

    Science.gov (United States)

    2012-11-13

    ... DEA registration. Serenity Caf , 77 FR 35027, 35028 (2012); David W. Wang, 72 FR 54297, 54298 (2007); Sheran Arden Yeates, 71 FR 39130, 39131 (2006); Dominick A. Ricci, M.D., 58 FR 51104 (1993); Bobby Watts, M.D., 53 FR 11919 (1988). Notwithstanding the foregoing, the Respondent contends that the...

  14. 76 FR 50950 - Drawbridge Operation Regulation; Isle of Wight (Sinepuxent) Bay, Ocean City, MD

    Science.gov (United States)

    2011-08-17

    ... (Sinepuxent) Bay, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The... of Wight (Sinepuxent) Bay, mile 0.5, at Ocean City, MD. The proposed change will alter the dates the... will then become highlighted in blue. In the ``Document Type'' drop down menu select ``Proposed...

  15. An audit questionnaire that examines specifically the management of technical activities clauses in ISO 15189.

    Science.gov (United States)

    Hartley, T F

    2010-01-01

    The aim of this study was to design an audit questionnaire that focuses on the management of the technical activities in a Diagnostic Pathology Laboratory. The ISO 15189 Standard is written in such a way that it continually moves back and forth from topics where the auditor needs to question bench level staff, to topics where the auditor needs to question Technical Management Staff. This makes for a disjointed audit process - both Bench Staff and Technical Managers are repeatedly interrupted. The solution was to do a clause by clause analysis of the Standard and assign the major responsibility for the compliance to each clause to either Technical Managers or Bench Staff. The Clauses were then grouped under four topic headings regardless of whether they were a Section 4 or Section 5 Clause. Two questionnaires have emerged - the one described in this work and one directed primarily towards the activities of bench staff. There are 95 questions and it takes approximately two hours to complete. PMID:23105892

  16. Clause/Term Resolution and Learning in the Evaluation of Quantified Boolean Formulas

    CERN Document Server

    Giunchiglia, E; Tacchella, A; 10.1613/jair.1959

    2011-01-01

    Resolution is the rule of inference at the basis of most procedures for automated reasoning. In these procedures, the input formula is first translated into an equisatisfiable formula in conjunctive normal form (CNF) and then represented as a set of clauses. Deduction starts by inferring new clauses by resolution, and goes on until the empty clause is generated or satisfiability of the set of clauses is proven, e.g., because no new clauses can be generated. In this paper, we restrict our attention to the problem of evaluating Quantified Boolean Formulas (QBFs). In this setting, the above outlined deduction process is known to be sound and complete if given a formula in CNF and if a form of resolution, called Q-resolution, is used. We introduce Q-resolution on terms, to be used for formulas in disjunctive normal form. We show that the computation performed by most of the available procedures for QBFs --based on the Davis-Logemann-Loveland procedure (DLL) for propositional satisfiability-- corresponds to a tree...

  17. Considerations concerning the criminal clause, expression of contractual principle and law abuse

    Directory of Open Access Journals (Sweden)

    Nora Andreea Daghie

    2009-06-01

    Full Text Available The criminal clause is an accessory convention through which the parts evaluate in advance the prejudiceinterestswhich come from the inexecution lato sensu of the contractual obligations. This convention named criminalclause is the expression of the contractual liberty principle and presents a singular practical utility but also someinconveniences. Thus the criminal clause allows avoiding the difficulties of judicial evaluation of prejudices-interests.In this way, the creditor is not obliged to evidence the existence and the size of the prejudice, in order to obtain thepayment of the amount of money or carrying out other patrimonial value established in the criminal clause beingsufficient the proof of non inexecution lato sensu of the contractual obligation. The criminal clause has also a strongcomminatory purpose, exercising a pressure on the debtor to make all possible to execute precisely the contractualobligation. Due to these reasons it is seen in doctrine by some of the authors as one of the main guarantees in our law.Also in the doctrine however, it is shown that the debtor can be constrained in some situations to accept establishing avery high amount in the criminal clause, sometimes with inequitable consequences, with damaging effect for thedebtor.

  18. H5MD: a structured, efficient, and portable file format for molecular data

    CERN Document Server

    de Buyl, Pierre; Höfling, Felix

    2013-01-01

    We propose a new open file format named "H5MD" for storing molecular simulation data such as trajectories of particle positions and velocities as well as thermodynamic observables that are tracked during the course of the simulation. H5MD files are HDF5 (Hierarchical Data Format) files with a specific hierarchy and naming scheme. Thus, H5MD inherits many benefits of HDF5, e.g., structured layout of multi-dimensional data sets, data compression, fast and parallel I/O, and portability across many programming languages and hardware platforms. H5MD files are self-contained, and foster the reproducibility of scientific data and the interchange of data between researchers using different simulation programs and analysis software. In addition, the H5MD specification can serve for other kinds of data (e.g. experimental data) and is extensible to supplemental data without breaking the compliance of the file to the specification.

  19. H5MD: A structured, efficient, and portable file format for molecular data

    Science.gov (United States)

    de Buyl, Pierre; Colberg, Peter H.; Höfling, Felix

    2014-06-01

    We propose a new file format named "H5MD" for storing molecular simulation data, such as trajectories of particle positions and velocities, along with thermodynamic observables that are monitored during the course of the simulation. H5MD files are HDF5 (Hierarchical Data Format) files with a specific hierarchy and naming scheme. Thus, H5MD inherits many benefits of HDF5, e.g., structured layout of multi-dimensional datasets, data compression, fast and parallel I/O, and portability across many programming languages and hardware platforms. H5MD files are self-contained, and foster the reproducibility of scientific data and the interchange of data between researchers using different simulation programs and analysis software. In addition, the H5MD specification can serve for other kinds of data (e.g. experimental data) and is extensible to supplemental data, or may be part of an enclosing file structure.

  20. PHP中的MD5加密机制探究

    Institute of Scientific and Technical Information of China (English)

    党长青

    2014-01-01

    MD5广泛用于加密和解密技术上。现阶段,存在两种加密方式,双向加密和单向加密。MD5是在Web应用程序中最常用的密码加密算法。由于MD5是不可逆的,因而经过MD5计算得到后的密文,不能通过逆向算法得到原文。在PHP应用程序中使用MD5加密文本密码的初衷,就是为了防止数据库中保存的密码不幸泄露后被直接获得。

  1. John Call Dalton, Jr., MD: America's first neurophysiologist.

    Science.gov (United States)

    Fine, E J; Manteghi, T; Sobel, S H; Lohr, L A

    2000-09-26

    Before the discoveries of John Call Dalton, Jr., MD (1824-1889), innervation of laryngeal muscles, long-term effects of cerebellar lesions, and consequences of raised intracranial pressure were poorly understood. Dalton discovered that the posterior cricoarytenoid muscles adducted the vocal cords during inspiration. He confirmed Flourens' observations that acute ablation of the cerebellum of pigeons caused loss of coordination. Dalton observed that properly cared for pigeons gradually recovered "coordinating power." Dalton observed that prolonged raised intracranial pressure caused tachycardia and then fatal bradycardia in dogs. Before Dalton published his photographic atlas of the human brain, neuroanatomy atlases were sketched by Europeans and imported into the United States. Dalton's atlas of the human brain contained precise photographs of vertical and horizontal sections that equal modern works. Before Dalton introduced live demonstrations of animals, physiology was taught by recitation of texts only. Dalton was the first American-born professor to teach physiology employing demonstrations of live animals operated on under ether anesthesia. He wrote an essay advocating experimentation on animals as the proper method of acquiring knowledge of function and that humane animal experimentation would ultimately improve the health of man and animals. His eloquent advocacy for humane experimental physiology quelled attacks by contemporaneous antivivisectionists. Dalton was America's first experimental neurophysiologist. PMID:10994009

  2. Studies of the TLR4-associated protein MD-2 using yeast-display and mutational analyses.

    Science.gov (United States)

    Mattis, Daiva M; Chervin, Adam S; Ranoa, Diana R; Kelley, Stacy L; Tapping, Richard I; Kranz, David M

    2015-12-01

    Bacterial lipopolysaccharide (LPS) activates the innate immune system by forming a complex with myeloid differentiation factor 2 (MD-2) and Toll-like receptor 4 (TLR4), which is present on antigen presenting cells. MD-2 plays an essential role in this activation of the innate immune system as a member of the ternary complex, TLR4:MD-2:LPS. With the goal of further understanding the molecular details of the interaction of MD-2 with LPS and TLR4, and possibly toward engineering dominant negative regulators of the MD-2 protein, here we subjected MD-2 to a mutational analysis using yeast display. The approach included generation of site-directed alanine mutants, and ligand-driven selections of MD-2 mutant libraries. Our findings showed that: (1) proline mutations in the F119-K132 loop that binds LPS were strongly selected for enhanced yeast surface stability, (2) there was a preference for positive-charged side chains (R/K) at residue 120 for LPS binding, and negative-charged side chains (D/E) for TLR4 binding, (3) aromatic residues were strongly preferred at F119 and F121 for LPS binding, and (4) an MD-2 mutant (T84N/D101A/S118A/S120D/K122P) exhibited increased binding to TLR4 but decreased binding to LPS. These studies revealed the impact of specific residues and regions of MD-2 on the binding of LPS and TLR4, and they provide a framework for further directed evolution of the MD-2 protein. PMID:26320630

  3. Md1 and Rp105 regulate innate immunity and viral resistance in zebrafish.

    Science.gov (United States)

    Candel, Sergio; Sepulcre, María P; Espín-Palazón, Raquel; Tyrkalska, Sylwia D; de Oliveira, Sofía; Meseguer, José; Mulero, Victoriano

    2015-06-01

    TLR4 was the first TLR family member identified in mammals and is responsible for the activation of the immune response by bacterial LPS. Later, MD1 and RP105 were shown to form complexes that directly interact with the MD2-TLR4 complex, acting as physiological negative regulators of LPS signaling. Despite the general conservation of various TLR families from fish to mammals, several differences can be appreciated, such as the high tolerance of fish to LPS, the absence of the crucial accessory molecules Md2 and Cd14 for Tlr4 signaling in fish, the absence of Tlr4 in some fish species, and the confirmation that LPS does not signal through Tlr4 in zebrafish. The present study has identified the Rp105 and Md1 homologs in zebrafish, confirming (i) Rp105 and Tlr4 evolved from a common ancestor before the divergence between fish and tetrapods and (ii) the presence of Md1 in teleost fish and the lack of Md2, suggesting that the divergence of these accessory molecules occurred in the tetrapod lineage. Biochemical and functional studies indicate that Md1 binds both Rp105 and Tlr4 in zebrafish. Genetic inhibition of zebrafish Md1 and Rp105 reveals that Md1 or Rp105 deficiency impairs the expression of genes encoding pro-inflammatory and antiviral molecules, leading to increased susceptibility to viral infection. These results shed light on the evolutionary history of Md1 and Rp105 and uncover a previously unappreciated function of these molecules in the regulation of innate immunity.

  4. A Study of L1 Transfer on the Use of Attributive Clauses In English Writing%A Study of L1 Transfer on the Use of Attributive Clauses In English Writing

    Institute of Scientific and Technical Information of China (English)

    边宛

    2011-01-01

    This study is carried out to find out the role of LI transfer on the problems of attributive clauses. By the application of Contrastive Analysis and Error Analysis, the study shows, Chinese belongs to the left-branching language, while English is the right- branching one in terms of the structure of attributive clauses.

  5. 木质素模型化合物香草醛Mannich反应及其产物化学结构表征%Mannich Reaction of Lignin Model Compound Vanillin and Chemical Structure Characterization of Its Product

    Institute of Scientific and Technical Information of China (English)

    聂明才; 孔振武; 霍淑平; 吴国民; 陈健

    2012-01-01

    Vanillin aminated polyol(VAP) was prepared by vanillin, diethanolamine and paraformaldehyde in 1,4-dioxane by Mannich reaction. The effects of material ratio, reaction temperature, reaction time and solvent dosage on the Mannich reaction were investigated. It was observed the highest conversion rate of diethanolamine was up to 84.92 % by dropping 1,3-oxazolidine which was the reaction product of formaldehyde and diethanolamine at 60℃ for 2 h, into vanillin and reacting at 80 ℃ for 3 h in the molar ratio of n( vanillin) : n( formaldehyde) : n(diethanolamine) as 1 : 1 : 1 in 1,4-dioxane of 100 mL/mol vanillin. The chemical structure of vanillin aminated polyol was characterized by HPLC, LC-MS, FT-IR and 'H NMR, respectively.%以木质素模型化合物香草醛、二乙醇胺及多聚甲醛为原料,1,4-二氧杂环己烷为溶剂,通过Mannich反应合成了香草醛胺基多元醇,研究了物料配比、反应温度、时间及溶剂用量等因素对Mannich反应的影响.实验结果表明:反应物料按物质的量比n(香草醛):n(甲醛):n(二乙醇胺)1:1:1,甲醛与二乙醇胺60℃反应2h生成1,3-氧氮杂环戊烷,再将其滴入香草醛中,80℃反应3h,二氧六环溶剂用量为100 mL/mol(以香草醛的物质的量计),二乙醇胺的转化率最高可达到84.92%.采用HPLC、LC- MS、FT-IR及H NMR表征了香草醛胺基多元醇的化学结构,相对分子质量269.

  6. THE UNPREDICTABILITY CLAUSE IN TRANSPORT CONTRACTS, ACCORDING TO THE NEW CIVIL CODE

    Directory of Open Access Journals (Sweden)

    Adriana Elena BELU

    2014-05-01

    Full Text Available Until the enforcement of the highly controversial transport law, transport companies must already observe the provisions of the new Civil Code1 in their transport business. One of the novelties in the new Civil Code, that came into force on October 1, 2011, refers to the unpredictability clause: recurring to this clause, in certain situations to be precisely analysed by courts, parties may even be exempted from certain contractual obligations, when the court decides to rescind the contract based on objective criteria, not imputable to the party that no longer can properly fulfil the obligations that had been undertaken when the contract had been made. However, this solution only is provided after all means of negotiation and mediation between parties are exhausted. The clause meets current market requirements, under which many companies have to deal with bad paying partners.

  7. Infinitival before and after-clauses in European Portuguese: temporal and aspectual properties

    Directory of Open Access Journals (Sweden)

    Purificação Silvano

    2015-06-01

    Full Text Available The main goal of this paper is to discuss temporal and aspectual features of sentences with clauses introduced by the connectives antes de + Infinitivo (‘before’ + Infinitive and depois de + Infinitivo (‘after’ + Infinitive combined with situations in the Pretérito Perfeito in European Portuguese. Our discussion is based on the widespread view that these clauses are locating adverbials (cf. Kamp and Reyle (1993 with temporal information of anteriority, in the case of antes de, and posteriority, in the case of depois de. However, this analysis is not as straightforward as one would expect, because, while before-clauses consistently render the same temporal relation (of anteriority, after-clauses may convey a temporal relation of inclusion, in addition to the standard posteriority relation. We put forward the hypothesis that aspectual characteristics play an important role in these differences, insofar as allowing a temporal reading that at first sight is not predicted from the semantic nature of the connective. In order to maintain a uniform treatment of before and after-clauses with respect to their temporal features, accounting simultaneously for the differences that emerge in their linguistic behaviour, we claim, along with Beaver & Condoravdi (2003 and Condoravdi (2010, that the locating time interval provided by these clauses is bounded to the left, but not to the right, that is, what is focused is the initial frontier of the situation that provides the time interval, leaving the final one undetermined. Furthermore, we show that, although the temporal mechanisms are parallel, the interference of aspectual properties leads to interesting differences in the final interpretation of before and after-sentences.

  8. 46 CFR 308.536 - Declaration where failure to comply with Clause 21 was inadvertent, Form MA-314.

    Science.gov (United States)

    2010-10-01

    ... inadvertent, Form MA-314. 308.536 Section 308.536 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF... Insurance § 308.536 Declaration where failure to comply with Clause 21 was inadvertent, Form MA-314. An... sufficient to meet the requirements of Clause 21 of the Policy shall file this Declaration, Form...

  9. 8 CFR 204.7 - Preservation of benefits contained in savings clause of Immigration and Nationality Act...

    Science.gov (United States)

    2010-01-01

    ... savings clause of Immigration and Nationality Act Amendments of 1976. 204.7 Section 204.7 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRANT PETITIONS Immigrant Visa Petitions § 204.7 Preservation of benefits contained in savings clause of Immigration and Nationality...

  10. 14 CFR 91.23 - Truth-in-leasing clause requirement in leases and conditional sales contracts.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Truth-in-leasing clause requirement in... OPERATING AND FLIGHT RULES General § 91.23 Truth-in-leasing clause requirement in leases and conditional... January 2, 1973, shall execute a written lease or contract and include therein a written...

  11. Development of Word Order in German Complement-Clause Constructions: Effects of Input Frequencies, Lexical Items, and Discourse Function

    Science.gov (United States)

    Brandt, Silke; Lieven, Elena; Tomasello, Michael

    2010-01-01

    We investigate the development of word order in German children's spontaneous production of complement clauses. From soon after their second birthday, young German children use both verb final complements with complementizers and verb-second complements without complementizers. By their third birthday they use both kinds of complement clauses with…

  12. The Design of MD5 Algorithm against Exhaustion Code-breaking and Its Realization%MD5算法防穷举(冲撞)破译的设计及其实现

    Institute of Scientific and Technical Information of China (English)

    廖思周

    2006-01-01

    在对MD5算法做简单介绍的基础上,针对攻击者拥有巨大密码字典、原文/密文对照数据库,设计了MD5变换算法,是对现有的MD5算法的延伸,大大提高了现成MD5密文的安全性.

  13. MD5算法及在用户口令加密应用中的改进%The Improved MD5 Algorithm in the Encryption of User Passwords

    Institute of Scientific and Technical Information of China (English)

    高洪波; 马素萍

    2010-01-01

    MD5是一种非常优秀的加密算法,曾被大量公司和个人广泛使用.但随着科学技术的发展,MD5牢不可破的神话逐渐破灭.基于此,在分析MD5加密算法及其弱点的前提下,探讨了MD5的改进算法.

  14. Den sene Derrida, eller: Er Claus Beck-Nielsen et spøgelse?

    DEFF Research Database (Denmark)

    Rösing, Lilian Munk

    2009-01-01

    This article is about hosting the ghost. In Spectres de Marx (1993) Derrida introduces the ghost which seems to condense in one figure the important themes of his late writings: the address, the other, the ethical turn, the event, the mourning, the reality of immateriality, the guest. The article...... turns to the paternal ghost from Shakespeare's Hamlet, as well as to the most ghost-like artist on the Danish contemporary art scene: Claus Beck-Nielsen, who some years ago declared himself dead. Is Claus Beck-Nielsen really a ghost? That is the question....

  15. Generation Y and their awareness of the Santa Claus Village in Rovaniemi

    OpenAIRE

    Saarinen, Hanna; Nordström, Tiia

    2015-01-01

    The Santa Claus Village is one of the biggest tourism attractions in Northern Finland, and the city of Rovaniemi has been titled as the “Official Hometown of Santa Claus”. This thesis studies the level of knowledge of the Santa Claus Village and the affect the village has on the incoming tourism in the Rovaniemi. More specifically the focus is on the perceptions of different nationalities and generation Y, as in young adults with no children. The thesis was commissioned by Rovaniemi Touri...

  16. 基于MD5的可逆无冗余加密算法%The Reversible Non-Redundant Encryption Algorithm Based on MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    陈钧; 刘爱华

    2012-01-01

    If MD5 algorithm is directly used to encrypt sensitive data in database, the data is unable to be deerypted by this algorithm itself, even legitimate users query or update some data for the purpose of restoring data. The database becomes more redundant because secret keys need to be saved for reversible encryption algorithms. This paper proposes a reversible non-redundant encryption algorithm based on MD5 algorithm, which can be ~ to used encrypt and decrypt sensitive data in the database regardless of saving secret keys.%直接采用MD5算法对数据库中的敏感数据加密时,合法用户进行查询、更新等操作需要还原数据,MD5算法无法解密数据.可逆的加密算法都需要保存密钥,数据库增加了数据的冗余.本文提出一种基于MD5算法的可逆无冗余算法,实现对数据库中敏感数据进行加密、解密,而且不需要保存密钥.

  17. Electroporation of archaeal lipid membranes using MD simulations.

    Science.gov (United States)

    Polak, Andraž; Tarek, Mounir; Tomšič, Matija; Valant, Janez; Ulrih, Nataša Poklar; Jamnik, Andrej; Kramar, Peter; Miklavčič, Damijan

    2014-12-01

    Molecular dynamics (MD) simulations were used to investigate the electroporation of archaeal lipid bilayers when subjected to high transmembrane voltages induced by a charge imbalance, mimicking therefore millisecond electric pulse experiments. The structural characteristics of the bilayer, a 9:91 mol% 2,3-di-O-sesterterpanyl-sn-glicerol-1-phospho-myo-inositol (AI) and 2,3-di-O-sesterterpanyl-sn-glicerol-1-phospho-1'(2'-O-α-D-glucosyl)-myo-inositol (AGI) were compared to small angle X-ray scattering data. A rather good agreement of the electron density profiles at temperatures of 298 and 343 K was found assessing therefore the validity of the protocols and force fields used in simulations. Compared to dipalmitoyl-phosphatidylcholine (DPPC), the electroporation threshold for the bilayer was found to increase from ~2 V to 4.3 V at 323 K, and to 5.2 V at 298 K. Comparing the electroporation thresholds of the archaeal lipids to those of simple diphytanoyl-phosphatidylcholine (DPhPC) bilayers (2.5 V at 323 K) allowed one to trace back the stability of the membranes to the structure of their lipid head groups. Addition of DPPC in amounts of 50 mol% to the archaeal lipid bilayers decreases their stability and lowers the electroporation thresholds to 3.8 V and 4.1 V at respectively 323 and 298 K. The present study therefore shows how membrane compositions can be selected to cover a wide range of responses to electric stimuli. This provides new routes for the design of liposomes that can be efficiently used as drug delivery carriers, as the selection of their composition allows one to tune in their electroporation threshold for subsequent release of their load.

  18. Characterization of an Autophagy-related Gene MdATG8i from apple

    Directory of Open Access Journals (Sweden)

    Ping eWang

    2016-05-01

    Full Text Available Nutrient deficiencies restrict apple (Malus sp. tree growth and productivity in Northwest China. The process of autophagy, a conserved degradation pathway in eukaryotic cells, has important roles in nutrient-recycling and helps improve plant performance during periods of nutrient-starvation. Little is known about the functioning of autophagy-related genes (ATGs in apple. In this study, one of the ATG8 gene family members MdATG8i was isolated from M. domestica. MdATG8i has conserved putative tubulin binding sites and ATG7 interaction domains. A 1865-bp promoter region cloned from apple genome DNA was predicated to have cis-regulatory elements responsive to light, environmental stresses and hormones. MdATG8i transcriptions were induced in response to leaf senescence, nitrogen depletion, and oxidative stress. At cellular level, MdATG8i protein was expressed in the nucleus and cytoplasm of onion epidermal cells. Yeast two-hybrid tests showed that MdATG8i could interact with MdATG7a and MdATG7b. In Arabidopsis, its heterologous expression was associated with enhanced vegetative growth, leaf senescence, and tolerance to nitrogen- and carbon-starvation. MdATG8i-overexpressing ‘Orin’ apple callus lines also displayed improved tolerance to nutrient-limited conditions. Our results demonstrate that MdATG8i protein could function in autophagy in a conserved way, as a positive regulator in the response to nutrient-starvation.

  19. Classification of 5-Dimensional MD-Algebras Having Non-Commutative Derived Ideals

    CERN Document Server

    Vu, Le Anh; Nghia, Tran Thi Hieu

    2011-01-01

    The paper presents a subclass of the class of MD5-algebras and MD5-groups, i.e. five dimensional solvable Lie algebras and Lie groups such that their orbits in the co-adjoint representation (K-orbits) are orbits of zero or maximal dimension. The main result of the paper is the classification up to an isomorphism of all MD5-algebras with the non-commutative derived ideal. With this result, we have the complete classification of 5-dimensional solvable Lie algebras.

  20. MD5算法应用失败的思考

    Institute of Scientific and Technical Information of China (English)

    TC-XB

    2007-01-01

    MD5算法作为一种高强度的加密算法,被广泛的应用于软件的注册算法中。但是需要指明的是.尽管MD5本身非常强大.但是如果应用不当,那么对软件的保护效果是很难令人满意的。下面我就先说一种最常见的MD5应用失败的形式。

  1. MD5优化算法及安全性分析%Analysis of MD5 Optimization Algorithm and Safety

    Institute of Scientific and Technical Information of China (English)

    张双斌

    2009-01-01

    针对目前MD5基本算法加密结果容易被破解的问题,在研究分析MD5、SHA-1及其系列算法加密原理的基础上,提出一种增加消息摘要长度的优化算法,使得破解时碰撞的概率减少很多倍,增强了系统加密的安全性.安全分析结果表明,MD5优化算法在保留了原算法加密速度的前提下,具有较原算法更好的抗攻击能力.

  2. A High Throughput FPGA Implementation of MD5 Algorithm%一种高吞吐量MD5算法的FPGA实现

    Institute of Scientific and Technical Information of China (English)

    刘凯; 车明; 秦存秀

    2008-01-01

    MD5数字摘要算法在网络安全的诸多方面都得到广泛的应用.由于其串行计算的特点,对MD5算法的加速并不像其它具有并行操作算法那样容易实现.提出了采用4级流水线的结构来提高MD5运算的吞吐量,可以提升至吉比特级.在设计中,参考了分布式存储模型的结构来实现低延迟、低资源消耗及更好的可扩展性.

  3. 芳香酮曼尼希碱酸化缓蚀剂的合成及复配研究%Synthesis and complex of the corrosion inhibitor of mannich bases of aromatic ketones

    Institute of Scientific and Technical Information of China (English)

    王霞; 白媛丽; 罗全民; 刘志辉

    2012-01-01

    37% Formaldehyde solution,acetophenone and diethylamine were chosed ultimately and these materials compounded a new type of mannich base hydrochloride acid inhibitor, and its complex research. The results showed that the best synthetic process conditions is diethylamine, formaldehyde, acetophenone molar ratio is:2:2:1 .reaction time is 8 h,reaction temperature is 80℃,,reaction system pH value is 4. Sodi-um tungstate and corrosion inhibitor have a positive synergies, potassium iodide negative synergistic effect.%以37%的甲醛溶液、苯乙酮和二乙胺为原料,合成一种新型曼尼希碱盐酸酸化缓蚀剂,并对其进行复配研究.结果表明,最佳合成条件为:二乙胺、37%甲醛溶液和苯乙酮的摩尔比为2:2:1,反应时间8h,反应温度80 ℃,pH值为4;钨酸钠和缓蚀剂有着很好的正协同效应,碘化钾与其有负协同效应.

  4. Synthesis of Mannich Base by One-pot Method with Aromatic Aldehyde, Acetophenone and p-Nitroaniline%芳香醛、苯乙酮和对硝基苯胺一锅法合成Mannich碱

    Institute of Scientific and Technical Information of China (English)

    温俏; 李小花; 林春秀; 徐达; 刘春玲

    2015-01-01

    在浓盐酸做催化剂的条件下,芳香醛、苯乙酮和对硝基苯胺能够发生Mannich反应,经过提纯得到相应的Mannich碱。用红外光谱对产物的结构进行表征,并研究浓盐酸的使用量、反应温度、反应时间等条件对产率的影响。实验发现在3滴浓盐酸催化下,控温在15~20℃,反应20 h,产率可达60%左右。%The Mannich base were synthesized by one-pot method with aromatic aldehyde, acetophenone and p-nitroaniline in concentrated hydrochloric acid. The structural properties of the products were characterized by IR spectrum. The influence of the factors of the quantity of catalyst, the reaction time and temperature on the product yield was systematically studied. It was found that under the conditions of 3 drops of concentrated hydrochloric acid as catalysis, in 15~20 ℃ and for 20 h, the production rate can reach 60%.

  5. HMAC-MD5的 FPGA 优化与实现%FPGA Optimization and Implementation of HMAC-MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    蔡啸; 李树国

    2015-01-01

    Data integrity and authenticity are very important in field of information security.HMAC-MD5 algorithm is one of the algorithms that achieve this target.The performance of its software implementation is very low and its FPGA hardware implementation is much higher.For the sake of higher throughput,this paper propose a two-to-one structure.As the result,it costs only 33 cycles to process 5 12 bits data.At the same time,the design support three kinds of mode:HMAC-MD5 computation with Key,HMAC-MD5 computation without key,MD5 computation. The design contains many optimization strategies such as pre-computation, microinstruction controller, the resources reuse etc.After synthesizing by Quartus II 13.0 on Stratix III devices,the clock frequency reaches 100 MHz,the throughput reaches 1.55 Gb/s and 1 120 ALUTs logic resources have been used.%在信息安全领域,数据完整性和真实性是十分重要的.HMAC-MD5算法是实现数据完整性和真实性验证的一种算法.HMAC-MD5的软件实现性能较低,而它的 FPGA 硬件实现性能较高.为了提高 FPGA 实现的性能,提出了一种二合一的结构,处理512 bit 数据周期数降低至33拍,提高了吞吐率,同时能够支持 HMAC-MD5带密钥输入和不带密钥输入、单 MD5运算的模式选择.本设计在 Stratix III 器件上使用 QuartusII 13.0进行综合,在使用了预计算、微指令控制器、资源复用等优化策略之后,最终综合出时钟频率为100 MHz,吞吐率达到1.55 Gb/s,逻辑资源使用为1120 ALUTs.

  6. Authentication in Networking Environment Based on LECC and MD5 Algorithm%基于LECC和MD5算法的网络身份认证

    Institute of Scientific and Technical Information of China (English)

    王小冬; 周海燕

    2015-01-01

    MD5算法常用于对远程用户进行身份认证,但其抵挡不了查字典或差分攻击.本文对用户身份进行MD5加密后,再采用LECC对密文进行纠错编码,提高算法抵御防攻击的能力.理论和实践证明,本算法具有较高的安全性和实用价值.

  7. Application of MD5 Algorithm in Office Automation System%MD5算法在办公自动化系统中的应用

    Institute of Scientific and Technical Information of China (English)

    张智发

    2008-01-01

    该文对办公自动化系统面临的风险进行了分析,介绍了MD5算法的特点和原理,把MD5算法应用于办公自动化系统中,解决了密码保护、信息完整性验证和数字签名等安全问题, 并给出了具体实现方法.

  8. 一种基于MD5算法的B/S通信加密系统%A MD5-based B/S communication encryption system

    Institute of Scientific and Technical Information of China (English)

    申甲

    2010-01-01

    随着网络的全面应用,以Web方式对数据进行操作的安全问题日益突出.本文针对目前广泛应用的MD5(Message Digest 5)加密算法,深入分析了MD5算法加密原理及实现过程,并利用该算法设计实现一种基于B/S(Browser/Server)方式的通信加密系统,达到了信息保密的要求.

  9. The acoustic characteristics of clause, sentence and paragraph boundaries in Chinese Putonghua

    Institute of Scientific and Technical Information of China (English)

    WANG Bei; YANG Yufang; L(U) Shinan

    2006-01-01

    The acoustic and perceptive characteristics of discourse units, including clauses,simple sentences, compound sentences and paragraphs, were studied. The acoustic characteristics were based on the analysis of a speech corpus consisted of ten monologues. The Perceived Boundary Strength (PBS) of the monologues was labeled on a five-point scale by 25 participants. The main results are as follows: (1) There is a significant difference in the PBS of clauses (corresponding to intonational phrase), sentences (including simple sentences and compound sentences) and paragraphs. But the PBS of simple sentences and compound sentences is the same, and the pitch reset and pause are also not significantly different between these two kinds of boundaries. (2) The pitch-based cue used to distinguish clauses, sentences and paragraphs appears to be the difference between pre- and post-boundary syllables, but not simply the pitch value of either syllable alone. (3) Declination mainly occurs within intonational phrases,whereas there is no consistent global declination in sentences or in paragraphs. (4) Pauses are longer and more varied at the boundary of larger discourse units. Moreover, there is a significant positive correlation between pause duration and degree of pitch reset at clause boundaries,but not at sentence or paragraph boundaries.

  10. 48 CFR 970.2703-1 - Purposes of patent rights clauses.

    Science.gov (United States)

    2010-10-01

    ... not have advance class waiver under 10 CFR part 784, the patent rights clause at 970.5227-11 is... 10 CFR part 784. Under such contracts, the M&O contractor assumes responsibilities for... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Purposes of patent...

  11. Children's Processing of Ambiguous Sentences: A Study of Relative Clause Attachment

    Science.gov (United States)

    Felser, Claudia; Marinis, Theodore; Clahsen, Harald

    2003-01-01

    In this study, we investigate children's and adults' relative clause attachment preferences in sentences such as "The student photographed the fan of the actress who was looking happy." Twenty-nine 6- to 7-year-old monolingual English children and 37 adult native speakers of English participated both in an auditory questionnaire study and in an…

  12. A constraint-based bottom-up counterpart to definite clause grammars

    DEFF Research Database (Denmark)

    Christiansen, Henning

    2004-01-01

    A new grammar formalism, CHR Grammars (CHRG), is proposed that provides a constraint-solving approach to language analysis, built on top of the programming language of Constraint Handling Rules in the same way as Definite Clause Grammars (DCG) on Prolog. CHRG works bottom-up and adds the following...

  13. 48 CFR 952.223 - Clauses related to environment, energy and water efficiency, renewable energy technologies...

    Science.gov (United States)

    2010-10-01

    ... environment, energy and water efficiency, renewable energy technologies, occupational safety, and drug-free workplace. 952.223 Section 952.223 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CLAUSES AND... related to environment, energy and water efficiency, renewable energy technologies, occupational...

  14. 37 CFR 401.3 - Use of the standard clauses at § 401.14.

    Science.gov (United States)

    2010-07-01

    ... clauses at § 401.14. (a) Each funding agreement awarded to a small business firm or nonprofit organization... have a place of business located in the United States or is subject to the control of a foreign... agreements with nonprofit organizations or small business firms shall accumulate and, at the request of...

  15. Sentence integration processes: An ERP study of Chinese sentence comprehension with relative clauses

    NARCIS (Netherlands)

    Yang, C.L.; Perfetti, C.A.; Liu, Y.

    2010-01-01

    In an event-related potentials (ERPs) study, we examined the comprehension of different types of Chinese (Mandarin) relative clauses (object vs. subject-extracted) to test the universality and language specificity of sentence comprehension processes. Because Chinese lacks morphosyntactic cues to sen

  16. The Acquisition of English Restrictive Relative Clauses by Arab Adult EFL Learners

    Directory of Open Access Journals (Sweden)

    Hayat Eid Alroudhan

    2016-02-01

    Full Text Available This study investigates the challenges faced by Arab adult learners of English as a foreign language (EFL in acquiring English restrictive relative clauses (RRCs, as well as the factors that affect the process of acquisition. This issue has received considerable attention in second language (L2 research. The present study discusses the syntactic structure of RRCs in English and Arabic with regard to the use of resumptive pronouns and the use of overt versus covert relative markers as related to the definiteness of the head noun. This study is carried out using an acceptability judgment test as the tool for data collection. A sample of 100 male and female adult Arabic speakers is used with the aim of identifying potential acquisition problems. The results obtained provide further support for first language (L1 transfer. This study concludes that participants accepted the use of resumptive pronouns and preferred the overt relative markers determined by definiteness. It is further discovered that certain factors influenced the acquisition process such as participants’ age, age of learning, and age of immersion. The current study has some pedagogical implications for the teaching of relative clauses in the EFL context.Keywords: English Relative Clauses, Restrictive Relative Clauses, Relative pronoun, Arab Learners of English

  17. 48 CFR 728.313 - Contract clauses for insurance of transportation or transportation-related services.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses for insurance of transportation or transportation-related services. 728.313 Section 728.313 Federal Acquisition...) USAID is required by law to include language in all its direct contracts and subcontracts ensuring...

  18. Force majeure clauses and the threat of nuclear disaster. A Japanese case study

    International Nuclear Information System (INIS)

    Force majeure clauses can be found in any commercial contract. Though more or less clear guidelines for the applicability of force majeure (clauses) exist in the form of international and national law, the applicability and enforceability of force majeure clauses with respect to nuclear incidents or disasters, however, remain ambiguous. Until the Japanese nuclear disaster, no major trade region was affected by any of the historical nuclear incidents. This case-study is based on the events surrounding the Tohoku earthquake, respective tsunami and nuclear incidents, especially at the Daiichi NPP and radiological contamination released there. The applicability and enforceability of force majeure clauses with their wide legal and economical implications are analyzed and evaluated according to the CISG and national domestic Japanese law. It is found that the assertion of force majeure is generally highly fact-specific and circumstance-sensitive. In general, the potential of nuclear disaster as an event triggering the force majeure defence is clearly evident, according to both international and Japanese law. Any claim must, however, be substantiated according to the principles of the different legal regimes under which the contract falls. In consequence, a company located within the evacuated areas will probably be able to successfully assert for majeure, whilst the success of any other claim will depend on the presentation of evidence, such as radiation levels and its effects in hindering performance of contractual obligations.

  19. An Inplementation of Pure Horn Clause Logic Programming in a Reduction System

    Institute of Scientific and Technical Information of China (English)

    许满武

    1993-01-01

    Many reduction systems have been presented for implementing functional programming languages.We propose here an extension of a reduction architecture to realize a kind of logic programming-pure Horn clause logic programming.This is an attempt to approach amalgamation of the two important programming paradigms.

  20. Force majeure clauses and the threat of nuclear disaster. A Japanese case study

    Energy Technology Data Exchange (ETDEWEB)

    Guderian, Stephan Michael

    2011-07-22

    Force majeure clauses can be found in any commercial contract. Though more or less clear guidelines for the applicability of force majeure (clauses) exist in the form of international and national law, the applicability and enforceability of force majeure clauses with respect to nuclear incidents or disasters, however, remain ambiguous. Until the Japanese nuclear disaster, no major trade region was affected by any of the historical nuclear incidents. This case-study is based on the events surrounding the Tohoku earthquake, respective tsunami and nuclear incidents, especially at the Daiichi NPP and radiological contamination released there. The applicability and enforceability of force majeure clauses with their wide legal and economical implications are analyzed and evaluated according to the CISG and national domestic Japanese law. It is found that the assertion of force majeure is generally highly fact-specific and circumstance-sensitive. In general, the potential of nuclear disaster as an event triggering the force majeure defence is clearly evident, according to both international and Japanese law. Any claim must, however, be substantiated according to the principles of the different legal regimes under which the contract falls. In consequence, a company located within the evacuated areas will probably be able to successfully assert for majeure, whilst the success of any other claim will depend on the presentation of evidence, such as radiation levels and its effects in hindering performance of contractual obligations.

  1. Reaction Mechanism for m-Xylene Oxidation in the Claus Process by Sulfur Dioxide.

    Science.gov (United States)

    Sinha, Sourab; Raj, Abhijeet; Al Shoaibi, Ahmed S; Chung, Suk Ho

    2015-09-24

    In the Claus process, the presence of aromatic contaminants such benzene, toluene, and xylenes (BTX), in the H2S feed stream has a detrimental effect on catalytic reactors, where BTX form soot particles and clog and deactivate the catalysts. Among BTX, xylenes are proven to be most damaging contaminant for catalysts. BTX oxidation in the Claus furnace, before they enter catalyst beds, provides a solution to this problem. A reaction kinetics study on m-xylene oxidation by SO2, an oxidant present in Claus furnace, is presented. The density functional theory is used to study the formation of m-xylene radicals (3-methylbenzyl, 2,6-dimethylphenyl, 2,4-dimethylphenyl, and 3,5-dimethylphenyl) through H-abstraction and their oxidation by SO2. The mechanism begins with SO2 addition on the radicals through an O-atom rather than the S-atom with the release of 180.0-183.1 kJ/mol of reaction energies. This exothermic reaction involves energy barriers in the range 3.9-5.2 kJ/mol for several m-xylene radicals. Thereafter, O-S bond scission takes place to release SO, and the O-atom remaining on aromatics leads to CO formation. Among four m-xylene radicals, the resonantly stabilized 3-methylbenzyl exhibited the lowest SO2 addition and SO elimination rates. The reaction rate constants are provided to facilitate Claus process simulations to find conditions suitable for BTX oxidation.

  2. Clause, Sentence, and Discourse Patterns in Selected Languages of Nepal: Part I, General Approach.

    Science.gov (United States)

    Hale, Austin

    This volume, the first in a series of four on the languages of Nepal, contains the following papers: "Toward the Systematization of Display Grammar,""Clause Patterns in Kham,""Tentative Systemic Organization of Nepali Sentences,""Maithili Sentences,""Notation for Simultaneous Representation of Grammatical and Sememic Components in Connected…

  3. Interpreting conjoined noun phrases and conjoined clauses: collective versus distributive preferences.

    Science.gov (United States)

    Clifton, Charles; Frazier, Lyn

    2012-01-01

    Two experiments are reported that show that introducing event participants in a conjoined noun phrase (NP) favours a single event (collective) interpretation, while introducing them in separate clauses favours a separate events (distributive) interpretation. In Experiment 1, acceptability judgements were speeded when the bias of a predicate toward separate events versus a single event matched the presumed bias of how the subjects' referents were introduced (as conjoined noun phrases or in conjoined clauses). In Experiment 2, reading of a phrase containing an anaphor following conjoined noun phrases was facilitated when the anaphor was they, relative to when it was neither/each of them; the opposite pattern was found when the anaphor followed conjoined clauses. We argue that comprehension was facilitated when the form of an anaphor was appropriate for how its antecedents were introduced. These results address the very general problem of how we individuate entities and events when presented with a complex situation and show that different linguistic forms can guide how we construe a situation. The results also indicate that there is no general penalty for introducing the entities or events separately-in distinct clauses as "split" antecedents. PMID:22512324

  4. 48 CFR 970.2703-2 - Patent rights clause provisions for management and operating contractors.

    Science.gov (United States)

    2010-10-01

    ... dedicated to naval nuclear propulsion or weapons related programs. That clause provides for DOE's statutory...-exempted areas of technology or in operation of DOE facilities primarily dedicated to naval nuclear propulsion or weapons related programs. (b) Allocation of Principal Rights: Government title. (1) The...

  5. Cognitive State Verbs and Complement Clauses in Children with SLI and Their Typically Developing Peers

    Science.gov (United States)

    Van Horne, Amanda J. Owen; Lin, Shanju

    2011-01-01

    This study investigated the use of cognitive state verbs (CSVs) and complement clauses in children with specific language impairment (SLI) and their typically developing (TD) peers. In Study 1, conversational samples from 23 children with SLI (M = 6;2), 24 age-matched TD children (M = 6;2) and 21 vocabulary-matched TD children (M = 4;9) were…

  6. 78 FR 73475 - Defense Federal Acquisition Regulation Supplement: Clauses With Alternates-Research and...

    Science.gov (United States)

    2013-12-06

    ... include your name, company name (if any), and ``DFARS Case 2013-D026'' on your attached document. Email... INFORMATION: I. Background In order to facilitate use of automated contract writing systems, DoD is processing... proposes to make the following changes: Amend section 235.072, Additional Contract Clauses, to reflect...

  7. Frequency Affects Object Relative Clause Processing: Some Evidence in Favor of Usage-Based Accounts

    Science.gov (United States)

    Reali, Florencia

    2014-01-01

    The processing difficulty of nested grammatical structure has been explained by different psycholinguistic theories. Here I provide corpus and behavioral evidence in favor of usage-based models, focusing on the case of object relative clauses in Spanish as a first language. A corpus analysis of spoken Spanish reveals that, as in English, the…

  8. Lichomolgus longicauda (Claus, 1860), Copepod parasite of Sepia, in the North Sea

    NARCIS (Netherlands)

    Stock, J.H.

    1956-01-01

    Lichomolgus longicauda (CLAUS, 1860), is recorded from the gills of Sepia officinalis, captured on 5 different occasions in the North Sea and the Dutch Waddensea. This means a northward extension of the range of this species of more than 8 degrees of latitude. Figures of the parasite have been provi

  9. Material Adverse Effect Clause – Proper Legal Work or Contribution to False Sense of Security?

    DEFF Research Database (Denmark)

    Fomcenco, Alex

    2014-01-01

    Regardless of whether you are a buyer or a seller, and regardless what the object of the contract is, it is essentially important that you seek to protect your rights through various clauses that must aim to provide clearness to contractual obligations, defini- tions of breach, and consequences...

  10. The Role of Working Memory and Contextual Constraints in Children's Processing of Relative Clauses

    Science.gov (United States)

    Wieghall, Anna R.; Altmann, Gerry T. M.

    2011-01-01

    An auditory sentence comprehension task investigated the extent to which the integration of contextual and structural cues was mediated by verbal memory span with 32 English-speaking six- to eight-year-old children. Spoken relative clause sentences were accompanied by visual context pictures which fully (depicting the actions described within the…

  11. A Corpus-based Approach to English Subordinate Clause I dentification

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The complex sentence structure of English is a bottleneck to our practical machi ne translation system. The simplification of English subordinate clauses will gr eatly relieves the burden of parsing and other grammatical or semantic analysis of a complex sentence, thus improves the output quality of the MT system. But th ere have not any satisfactory research achievements reported in this field up t o now as we know. In this paper, author's work on a corpus-based approach to English subordinate clause identification is reported. The approach integrate s rule-base d and statistical methods to get the left and right boundaries of the subordinat e clauses. The Penn Treebank corpus is used as the training standard. The precis ion and recall ratios of subordinate clause identification are tested on both cl osed and open corpora. A result of 92.9% precision and 91.26% recall is obtained for the closed test and the open test result is 80.34% precision and 83.93% rec all. This algorithm has been integrated into our machine translation system. The method can also be applied to processing of any other language.

  12. A Discourse Explanation of the Grammar of Relative Clauses in English Conversation.

    Science.gov (United States)

    Fox, Barbara A.; Thompson, Sandra A.

    1990-01-01

    In communicating, conversationalists constantly make decisions about their interlocutors' state of knowledge and on the basis of these decisions make lexical, grammatical, and intonational choices about how to manage the "flow" of information. This paper focuses on how such decision making affects choices in relative clause constructions in…

  13. 29 CFR 2580.412-19 - Term of the bond, discovery period, other bond clauses.

    Science.gov (United States)

    2010-07-01

    ... SECURITY ACT OF 1974 TEMPORARY BONDING RULES General Bond Rules § 2580.412-19 Term of the bond, discovery... 29 Labor 9 2010-07-01 2010-07-01 false Term of the bond, discovery period, other bond clauses... new bond must be obtained each year. There is nothing in the Act that prohibits a bond for a...

  14. 12 CFR Appendix G to Part 226 - Open-End Model Forms and Clauses

    Science.gov (United States)

    2010-01-01

    ... problem with the quality of property or services that you purchased with a credit card, and you have tried... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Open-End Model Forms and Clauses G Appendix G to Part 226 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE...

  15. The Meaning of Mood – Embedded Clauses in Spanish as a Case in Point

    DEFF Research Database (Denmark)

    Jensen, Helle Dam

    2011-01-01

    to be the result of an interpretive process. This article explains how mental space theory can be used in an analysis of mood in embedded clauses in Spanish. It starts from the assumption that the meaning of mood is constructed by interlocutors in an interpretive process on the basis of information from the modal...

  16. 48 CFR 719.273-11 - Solicitation provision and contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Solicitation provision and contract clause. 719.273-11 Section 719.273-11 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS The U.S. Agency for...

  17. Milestone report on MD potential development for uranium silicide

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Jianguo [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.; Zhang, Yongfeng [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.; Hales, Jason Dean [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.

    2016-03-01

    This report summarizes the progress on the interatomic potential development of triuranium-disilicide (U3Si2) for molecular dynamics (MD) simulations. The development is based on the Tersoff type potentials for single element U and Si. The Si potential is taken from the literature and a Tersoff type U potential is developed in this project. With the primary focus on the U3Si2 phase, some other U-Si systems such as U3Si are also included as a test of the transferability of the potentials for binary U-Si phases. Based on the potentials for unary U and Si, two sets of parameters for the binary U-Si system are developed using the Tersoff mixing rules and the cross-term fitting, respectively. The cross-term potential is found to give better results on the enthalpy of formation, lattice constants and elastic constants than those produced by the Tersoff mixing potential, with the reference data taken from either experiments or density functional theory (DFT) calculations. In particular, the results on the formation enthalpy and lattice constants for the U3Si2 phase and lattice constants for the high temperature U3Si (h-U3Si) phase generated by the cross-term potential agree well with experimental data. Reasonable agreements are also reached on the elastic constants of U3Si2, on the formation enthalpy for the low temperature U3Si (m-U3Si) and h-U3Si phases, and on the lattice constants of m-U3Si phase. All these phases are predicted to be mechanically stable. The unary U potential is tested for three metallic U phases (α, β, γ). The potential is found capable to predict the cohesive energies well against experimental data for all three phases. It matches reasonably with previous experiments on the lattice constants and elastic constants of αU.

  18. Collision Attack on the Full Extended MD4 and Pseudo-Preimage Attack on RIPEMD

    Institute of Scientific and Technical Information of China (English)

    Gao-Li Wang

    2013-01-01

    The cryptographic hash functions Extended MD4 and RIPEMD are double-branch hash functions,which consist of two parallel branches.Extended MD4 was proposed by Rivest in 1990,and RIPEMD was devised in the framework of the RIPE project (RACE Integrity Primitives Evaluation,1988~1992).On the basis of differential analysis and meet-in-the-middle attack principle,this paper proposes a collision attack on the full Extended MD4 and a pseudo-preimage attack on the full RIPEMD respectively.The collision attack on Extended MD4 holds with a complexity of 237,and a collision instance is presented.The pseudo-preimage attack on RIPEMD holds with a complexity of 2125,4,which optimizes the complexity order for brute-force attack.The results in this study will also be beneficial to the analysis of other double-branch hash functions such as RIPEMD-160.

  19. 好压的MD5校验功能

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    为了防止人为篡改文件.一般网上供网民下载的文件都公布了其MD5校验值,下载到本机后通过比较MD5校验值是否发生变化来判断文件是否被篡改。先选中文件,再点击好压软件“工具”菜单里的“MD5校验工具”就可查看到该文件的相关校验,可以对任意文件进行版本、文件时间、MD5值、SHAl值和CRC32值进行校验。

  20. MD5加密验证拿下

    Institute of Scientific and Technical Information of China (English)

    Crack

    2005-01-01

    在软件的加密保护中,MD5是一个经常会被用到的加密算法,但是由于MD5算法为不可逆算法所以所有的软件都只能使用MD5算法作为一个加密的中间步骤,比如对用户名做一个MD5变换,结果再进行一个可逆的加密变换,变换结果为注册码;

  1. 感受MD5暴力破解的魅力

    Institute of Scientific and Technical Information of China (English)

    冰河洗剑

    2005-01-01

    MD5密码一直是最头疼的,许多论坛和网站的密码都是MD5加密过的。当然得到了MD5加密过的密码后.有的高手可以通过Cookie欺骗或Session欺骗等方式.进入后台管理页面,但是对许多朋友来说,暴力破解MD5密码.将其还原为明文密码.再登录后台虽然有些笨.但却是比较简单有效的一种方法。

  2. 简单编写MD5破解器

    Institute of Scientific and Technical Information of China (English)

    人鱼姬

    2007-01-01

    目前国内的网络安全现状不容乐观.脚本注入还大有市场。许多脚本小子喜欢用注入工具到处乱注.拿到了管理员密码的MD5密文就开始破解,但并不是所有人都知道MD5破解是如何实现的。下面我们就用Delphi来编写一款简单的MD5破解器.同时让大家更清晰地了解MD5破解是基于什么原理实现的。

  3. 在线破解MD5网站一览

    Institute of Scientific and Technical Information of China (English)

    Tashanenjoy

    2006-01-01

    MD5加密因其不可逆性而导致了一些爆破猜测MD5工具的出现.如著名的MD5Crack.其原理是先进行MD5加密再对比提供的字符串。虽然速度也较快.但毕竟还是要“跑”一下具。有时一个密码跑30分钟也不一定能跑出来.很不划算。有没有其他的办法呢?

  4. 75 FR 12563 - Patuxent Research Refuge, Anne Arundel and Prince George's Counties, MD

    Science.gov (United States)

    2010-03-16

    ... Scarlet Tanager Loop, Laurel, MD 20708. FOR FURTHER INFORMATION CONTACT: Brad Knudsen, Refuge Manager... team leader or project leader (see ADDRESSES). You may also send comments anytime during the...

  5. EMC/FDTD/MD simulation of carrier transport and electrodynamics in two-dimensional electron systems

    OpenAIRE

    Sule, N; Willis, K. J.; Hagness, S. C.; Knezevic, I.

    2014-01-01

    We present the implementation and application of a multiphysics simulation technique to carrier dynamics under electromagnetic excitation in supported two-dimensional electronic systems. The technique combines ensemble Monte Carlo (EMC) for carrier transport with finite-difference time-domain (FDTD) for electrodynamics and molecular dynamics (MD) for short-range Coulomb interactions among particles. We demonstrate the use of this EMC/FDTD/MD technique by calculating the room-temperature dc an...

  6. 下载软件的MD5你检验了吗?

    Institute of Scientific and Technical Information of China (English)

    胥忠亮

    2009-01-01

    大家经常在网上下东西.可是下载下来的软件很有可能带有木马。通常软件发布者在发布软件的时候会附上软件的MD5.来防止软件被他人篡改。那程序的MD5值是什么呢?

  7. 软件保护中MD5算法的另类应用

    Institute of Scientific and Technical Information of China (English)

    TC—XB

    2006-01-01

    作为一种主流的加密算法,MD5算法广泛的应用于软件保护领域。在软件的注册保护中,MD5经常被用来对输入的注册信息进行加密。一般来说较为简单常见的用法是“MD5(注册名)=注册码”或是“MD5(注册名:机器码)=注册码”。这样的加密方法有一定的保护效果,但是随着破解技术的进步,对于这种保护方式,破解者只要能判断出使用了MD5算法,就可以很方便的做出注册机。不过不能因此否认MD5算法的优越性,所以对于MD5在软件的保护中应用,就要另辟蹊径了。下文中我们以一个Crackme为例,来看看如何更有效的使用MD5算法,并产生更好的保护效果。

  8. Summary of LHC MD 369: DOROS vs WBTN in IR Stripline BPMs

    CERN Document Server

    Draskovic, Drasko; Calvo Giraldo, Eva; Olexa, Jakub; Gasior, Marek; CERN. Geneva. ATS Department

    2015-01-01

    The aim of this MD is to quantify the impact of the stripline beam position monitor (BPM) directivity with two acquisition chain electronics systems, WBTN (Wide Band Time Normalizer) and DOROS (Diode ORbit and Oscillation System). This impact depends on the relative position and intensity of the two beams at the location of the monitor. This note explains all the procedures of the LHC MD 369, which took place on 20/07/2015 and presents the obtained results.

  9. Comparison of time adjustment clauses between DZ3910, AS4000 and STCC

    Directory of Open Access Journals (Sweden)

    David Finnie

    2013-03-01

    Full Text Available This article examines time adjustment clauses, as they relate to time adjustment between standard terms of construction contracts. DZ3910, AS4000 and STCC were compared on the basis of how risks are allocated, how this may impact on the contractor’s pricing, and ease of understanding for each clause. ASTCC was found to be the most easily interpreted contract, followed by AS4000 and then NZS3910. These assessments were based on the following: a whether each contract contains words with multiple meanings, b the number of words used per sentence, c the amount of internal cross-referencing, and d the clarity of the contract structure. The allowable pre-conditions for the contractor to claim a time adjustment are similar for all three contracts, and none of them expressly state which party is to bare the risk of buildability, or address the risk of a designer’s disclaimer clause. All of the contracts adopt the principle of contra preferentum which means that the employer bares the risk of variance if there are any ambiguities in the design documentation. Due to their similarities of risk allocation, all of the contracts provide the employer with a similar amount of price surety. AS4000 is the only contract to contain a stringent time-bar clause, limiting a contractor’s time adjustment claim. ASTCC requires the contractor to apply ‘immediately’ and DZ3910 provides a time-bar of 20 working days or as soon as practicable. None of the contracts clarify whether their timing requirements take precedence over the prevention principle, or over any other ground for claiming a time adjustment. The effect of DZ3910’s pre-notification clause 5.19.3 is discussed, and an alternative contents structure is recommended for DZ3910, using a project management method. 

  10. The Origination Clause, the Affordable Care Act, and Indirect Constitutional Violations.

    Science.gov (United States)

    Dysart, Tessa L

    2015-01-01

    "All bills for raising revenue shall originate in the House of Representatives; but the Senate may propose or concur with amendments as on other Bills." U.S. Const. art. I, § 7, cl. 1 (Origination Clause). "As we have often noted, '[c]onstitutional rights would be of little value if they could be . . . indirectly denied.'" United States Term Limits, Inc. v. Thornton, 514 U.S. 779, 829 (1995) The Supreme Court's opinion in National Federation of Independent Business v. Sebelius, upholding the constitutionality of the Patient Protection and Affordable Care Act (ACA) as a permissible exercise of Congress's taxing power rekindled an old question about the constitutionality of the Act: Was the Act unconstitutional under the Origination Clause? The bill that became the ACA, H.R. 3590, originated in the House as the Service Members Home Ownership Tax Act of 2009. It was gutted by the Senate and replaced with the ACA before being passed and sent back to the House for final passage. The Supreme Court has heard very few cases on the Origination Clause, and Origination Clause challenges have met with little success. Most of these cases have developed over the questions of whether the bill is actually a revenue-raising bill that is constitutionally required to be originate in the House, and, if so, whether the Senate amendments were appropriate. But United States Term Limits v. Thornton provides another angle under which to examine the constitutionality of the ACA: an indirect violation of a constitutional prohibition. In this Article, I will provide an overview of the ACA's passage and analyze it through the lenses of traditional Origination Clause arguments and the Term Limits approach.

  11. Comparison of time adjustment clauses between DZ3910, AS4000 and STCC

    Directory of Open Access Journals (Sweden)

    David Finnie

    2013-03-01

    Full Text Available This article examines time adjustment clauses, as they relate to time adjustment between standard terms of construction contracts. DZ3910, AS4000 and STCC were compared on the basis of how risks are allocated, how this may impact on the contractor’s pricing, and ease of understanding for each clause. ASTCC was found to be the most easily interpreted contract, followed by AS4000 and then NZS3910. These assessments were based on the following: a whether each contract contains words with multiple meanings, b the number of words used per sentence, c the amount of internal cross-referencing, and d the clarity of the contract structure. The allowable pre-conditions for the contractor to claim a time adjustment are similar for all three contracts, and none of them expressly state which party is to bare the risk of buildability, or address the risk of a designer’s disclaimer clause. All of the contracts adopt the principle of contra preferentum which means that the employer bares the risk of variance if there are any ambiguities in the design documentation. Due to their similarities of risk allocation, all of the contracts provide the employer with a similar amount of price surety. AS4000 is the only contract to contain a stringent time-bar clause, limiting a contractor’s time adjustment claim. ASTCC requires the contractor to apply ‘immediately’ and DZ3910 provides a time-bar of 20 working days or as soon as practicable. None of the contracts clarify whether their timing requirements take precedence over the prevention principle, or over any other ground for claiming a time adjustment. The effect of DZ3910’s pre-notification clause 5.19.3 is discussed, and an alternative contents structure is recommended for DZ3910, using a project management method.

  12. Parallel Cascade Selection Molecular Dynamics (PaCS-MD) to generate conformational transition pathway.

    Science.gov (United States)

    Harada, Ryuhei; Kitao, Akio

    2013-07-21

    Parallel Cascade Selection Molecular Dynamics (PaCS-MD) is proposed as a molecular simulation method to generate conformational transition pathway under the condition that a set of "reactant" and "product" structures is known a priori. In PaCS-MD, the cycle of short multiple independent molecular dynamics simulations and selection of the structures close to the product structure for the next cycle are repeated until the simulated structures move sufficiently close to the product. Folding of 10-residue mini-protein chignolin from the extended to native structures and open-close conformational transition of T4 lysozyme were investigated by PaCS-MD. In both cases, tens of cycles of 100-ps MD were sufficient to reach the product structures, indicating the efficient generation of conformational transition pathway in PaCS-MD with a series of conventional MD without additional external biases. Using the snapshots along the pathway as the initial coordinates, free energy landscapes were calculated by the combination with multiple independent umbrella samplings to statistically elucidate the conformational transition pathways.

  13. 不要宰牛刀,MD5值校对更方便

    Institute of Scientific and Technical Information of China (English)

    新玲的窗户

    2009-01-01

    在一些比较正规的网站或论坛下载软件时,在软件下载链接旁边一般都会提供该软件原始的MD5值。用MD5值工具计算出下载软件的MD5值,和原始MD5值进行校对,就可判断出下载的软件是否被修改过。但是,使用专门的工具对下载的软件进行MD5值校对比较麻烦,二来也有“杀鸡用牛刀”之嫌。其实,仅仅利用一个动态链接库文件,就可以完成MD5值的校对工作。

  14. 防止密码MD5值被破解妙招

    Institute of Scientific and Technical Information of China (English)

    晏伟

    2006-01-01

    现在的站点当中有很多密码都是经过MD5加密的,有很多人认为经过MD5加密后的密码就是安全的,即使密码MD5值被暴露也无所谓,殊不知有很多站点都能够对MD5值进行穷举解密,这些站点能够在瞬间还原1O位以下字母+数字+字符组合的密码。有些站点甚至声称数据库中有235亿条记录,这是件很可怕的事情,如果你的密码不够强大,只是由简单数字或几个字母组成,MD5值也相当于是明文!下面我就教大家一招防止MD5值被破解的妙招。

  15. Novel matrine derivative MD-1 attenuates hepatic fibrosis by inhibiting EGFR activation of hepatic stellate cells.

    Science.gov (United States)

    Feng, Yi; Ying, Hai-Yan; Qu, Ying; Cai, Xiao-Bo; Xu, Ming-Yi; Lu, Lun-Gen

    2016-09-01

    Matrine (MT), the effective component of Sophora flavescens Ait, has been shown to have anti-inflammation, immune-suppressive, anti-tumor, and anti-hepatic fibrosis activities. However, the pharmacological effects of MT still need to be strengthened due to its relatively low efficacy and short half-life. In the present study, we report a more effective thio derivative of MT, MD-1, and its inhibitory effects on the activation of hepatic stellate cells (HSCs) in both cell culture and animal models. Cytological experiments showed that MD-1 can inhibit the proliferation of HSC-T6 cells with a half-maximal inhibitory concentration (IC50) of 62 μmol/L. In addition, MD-1 more strongly inhibits the migration of HSC-T6 cells compared to MT and can more effectively induce G0/G1 arrest and apoptosis. Investigating the biological mechanisms underlying anti-hepatic fibrosis in the presence of MD-1, we found that MD-1 can bind the epidermal growth factor receptor (EGFR) on the surface of HSC-T6 cells, which can further inhibit the phosphorylation of EGFR and its downstream protein kinase B (Akt), resulting in decreased expression of cyclin D1 and eventual inhibition of the activation of HSC-T6 cells. Furthermore, in rats with dimethylnitrosamine (DMN)-induced hepatic fibrosis, MD-1 slowed the development and progression of hepatic fibrosis, protecting hepatic parenchymal cells and improving hepatic functions. Therefore, MD-1 is a potential drug for anti-hepatic fibrosis.

  16. INHERENT VICE & INSUFFICIENT PACKING CLAUSES FOR ALL RISKS INSURANCE POLICIES UNDER BRITISH INSTITUTE CARGO CLAUSES : legal issues arising from claims of loss during sea transportation of large technical equipments

    OpenAIRE

    2010-01-01

    Analysis and presentation of this thesis is supported by studies of many relevant cases where the major arguments are set around the exclusion clauses concerning the ‘all risks cover’ policy as found in Institute Cargo Clauses. Two cases are especially emphasized, namely Mayban General Assurance BHD v. Alstom Power Plants Ltd. and Global Process Systems Inc v. Syarikat Takaful Malaysia Berhad , mainly because of the special nature of the subject matter insured in these cases. The legal i...

  17. Evaluation of hydroacid complex in the forward osmosis–membrane distillation (FO–MD) system for desalination

    KAUST Repository

    Wang, Peng

    2015-11-01

    The incorporation of membrane distillation (MD) into forward osmosis (FO) provides process sustainability to regenerate the draw solution and to produce clean water simultaneously. However, the reverse salt flux is the major hurdle in the FO-MD system because it not only reduces the effective osmotic driving force across the membrane but also increases the replenishment cost and scaling issue. For the first time, a hydroacid complex with abundant hydrophilic groups and ionic species is evaluated as the draw solutes in the hybrid FO-MD system consisting of multi-bore PVDF MD membranes for seawater/brackish desalination. In order to evaluate the practicality of the hydroacid complex in the FO-MD system, FO and MD experiments were conducted at elevated temperatures and concentrations. The hydroacid complex has displayed desired properties such as high solubility, low viscosity, excellent thermal stability and minimal reverse salt flux suitable for FO and MD operations. FO-MD desalination process was demonstrated with a highest seawater desalination flux of 6/32 LMH (FO/MD). This study may open up the prospective of employing the hydroacid complex as the draw solute in FO-MD hybrid systems for seawater /brackish desalination. © 2015 Elsevier B.V.

  18. Synthesis and Performance of Mannich Base Quaternary Ammonium Salt Acidizing Corrosion Inhibitor%曼尼希碱季铵盐酸化缓蚀剂的合成及性能

    Institute of Scientific and Technical Information of China (English)

    赵顺强; 孙永涛; 马增华; 付朝阳

    2014-01-01

    合成了一种新型的曼尼希碱季铵盐(BMQA)酸化缓蚀剂,通过静态失重法测试了缓蚀剂在不同浓度盐酸中的缓蚀性能。结果表明,90℃下,缓蚀剂 BMQA 在15%盐酸中加入0.1%,18%盐酸中加入0.2%,28%盐酸中加入0.5%,N80钢的腐蚀速率都能小于4 g·m-2·h-1。极化曲线测试表明该缓蚀剂是抑制阳极为主的混合型缓蚀剂,遵循 Langmuir 吸附等温式,能自发在金属表面进行化学吸附。%A new type of Mannich base quaternary ammonium salt was synthesized as an acidification corrosion inhibitor.The inhibition performance of this corrosion inhibitor was evaluated in hydrochloric acid with different concentrations by static weight loss method.The results showed that with 0.1% inhibitor in 15% hydrochloric acid, 0.2% inhibitor in 18% hydrochloric acid and 0.5% inhibitor in 28% hydrochloric acid,the corrosion rates of steel N80 were all lower than 4 g·m-2 ·h-1 at 90℃.Polarization curves indicate that the corrosion inhibitor is a mixed inhibitor but mainly prohibits the anodic corrosion process,obeys the Langmuir adsorption isothermal equation and can spontaneously absorb on the steel surface by chemisorption.

  19. Trap of a Ceteris Paribus Clause in Inductive Argument : An Essay on Theory of Confirmation (No.1)

    OpenAIRE

    ハラダ, アキノブ; Akinobu, Harada

    1999-01-01

    Modern inductive sciences, e.g., mathematical theory of probability, statistics and economics, are now in the face of a lack of reality. This paper argues the logical problem on a variety of petitio principii arisen from a ceteris paribus clause available to usual inference. The problem concretely is that on the validity of a ceteris paribus clause to confirmation of hypothesis from the point of view of epistemology, not from that of mathematics. First, we tentatively define conditional proba...

  20. PuReMD-GPU: A reactive molecular dynamics simulation package for GPUs

    Energy Technology Data Exchange (ETDEWEB)

    Kylasa, S.B., E-mail: skylasa@purdue.edu [Department of Elec. and Comp. Eng., Purdue University, West Lafayette, IN 47907 (United States); Aktulga, H.M., E-mail: hmaktulga@lbl.gov [Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, MS 50F-1650, Berkeley, CA 94720 (United States); Grama, A.Y., E-mail: ayg@cs.purdue.edu [Department of Computer Science, Purdue University, West Lafayette, IN 47907 (United States)

    2014-09-01

    We present an efficient and highly accurate GP-GPU implementation of our community code, PuReMD, for reactive molecular dynamics simulations using the ReaxFF force field. PuReMD and its incorporation into LAMMPS (Reax/C) is used by a large number of research groups worldwide for simulating diverse systems ranging from biomembranes to explosives (RDX) at atomistic level of detail. The sub-femtosecond time-steps associated with ReaxFF strongly motivate significant improvements to per-timestep simulation time through effective use of GPUs. This paper presents, in detail, the design and implementation of PuReMD-GPU, which enables ReaxFF simulations on GPUs, as well as various performance optimization techniques we developed to obtain high performance on state-of-the-art hardware. Comprehensive experiments on model systems (bulk water and amorphous silica) are presented to quantify the performance improvements achieved by PuReMD-GPU and to verify its accuracy. In particular, our experiments show up to 16× improvement in runtime compared to our highly optimized CPU-only single-core ReaxFF implementation. PuReMD-GPU is a unique production code, and is currently available on request from the authors.

  1. A Study of the Adsorption of Molecular Deposition Filming Flooding Agent MD-1 on Quartz Sand

    Institute of Scientific and Technical Information of China (English)

    GaoManglai; LiuYong; MengXiuxia; WangJianshe

    2004-01-01

    Molecular deposition filming flooding (MDFF) is a novel oil recovery technique based on the thermopositive monolayer electrostatic adsorption of the MDFF agent on different interfaces within reservoir systems. In this paper, the adsorption property of the MDFF agent, MD-I, on quartz sand has been studied through adsorption experiments at different pH and temperatures. Experimental data are also analyzed kinetically and thermodynamically. The results show that the adsorption of MD-I on quartz sand takes place mainly because of electrostatic interactions, which corresponds to adsorption that increases with pH. Kinetic analyses show that at a higher pH the activation energy for adsorption gets lower and, therefore, the adsorption becomes quicker for MD-1 on quartz sand. Thermodynamic analyses show that pH plays an important role in the adsorption of MD-1 on quartz sand. At a higher pH, more negative surface charges result in the increase of electrostatic interactions between MD-1 and quartz sand. Therefore, the saturated adsorption amount increases and more adsorption heat will be released.

  2. Chosen-Prefix Collisions for MD5 and Colliding X.509 Certificates for Different Identities

    Science.gov (United States)

    Stevens, Marc; Lenstra, Arjen; de Weger, Benne

    We present a novel, automated way to find differential paths for MD5. As an application we have shown how, at an approximate expected cost of 250 calls to the MD5 compression function, for any two chosen message prefixes P and P', suffixes S and S' can be constructed such that the concatenated values P||S and P'||S' collide under MD5. Although the practical attack potential of this construction of chosen-prefix collisions is limited, it is of greater concern than random collisions for MD5. To illustrate the practicality of our method, we constructed two MD5 based X.509 certificates with identical signatures but different public keys and different Distinguished Name fields, whereas our previous construction of colliding X.509 certificates required identical name fields. We speculate on other possibilities for abusing chosen-prefix collisions. More details than can be included here can be found on www.win.tue.nl/hashclash/ChosenPrefixCollisions/.

  3. Whatever happened to the Norwegian Medical Need Clause? Lessons for current debates in EU pharmaceutical regulation.

    Science.gov (United States)

    Brooks, Eleanor; Geyer, Robert

    2016-05-01

    Until 1994, pharmaceutical products seeking market authorisation in Norway were required to demonstrate a fulfilment of unmet medical need. This clause enabled the national regulator to dramatically limit the number of products on the market whilst encouraging price competition to keep drug expenditure low and was credited with encouraging the development of drugs with genuine added therapeutic value and reducing the incidence of antimicrobial resistance. Norway was forced to abandon its Medical Need Clause (MNC) when it joined the European Economic Area as it was incompatible with the acquis communautaire of the European Union. This article reviews Norway's experience with its MNC in light of contemporary debates in European health policy. It discusses the potential contribution of an MNC-style regulation to improving health, reducing illness, ensuring sustainable health systems and fostering pharmaceutical innovation. It concludes by asking how these findings can inform current European Union debates over the growing cost of prescription drugs and direction of pharmaceutical development. PMID:26564268

  4. 英语定语从句的翻译%Translation of English Attributive Clause

    Institute of Scientific and Technical Information of China (English)

    谢亚卓

    2015-01-01

    Attributive clause doesn’t exist in Chinese, but is widely used in English. It is also one of the major obstacles to translators in translation. The structures of the English attributive clauses are simple or complex, translators need to take the appropriate translation skills to translate them flexibly.%定语从句是汉语中没有而英语中却广泛使用的语言现象,也是译者翻译中的重大障碍之一。英语定语从句的结构有简有繁,翻译时需要采取恰当的翻译技巧来灵活处理。

  5. Enhancing Extraction of Drug-Drug Interaction from Literature Using Neutral Candidates, Negation, and Clause Dependency

    Science.gov (United States)

    Bokharaeian, Behrouz; Diaz, Alberto; Chitsaz, Hamidreza

    2016-01-01

    Motivation Supervised biomedical relation extraction plays an important role in biomedical natural language processing, endeavoring to obtain the relations between biomedical entities. Drug-drug interactions, which are investigated in the present paper, are notably among the critical biomedical relations. Thus far many methods have been developed with the aim of extracting DDI relations. However, unfortunately there has been a scarcity of comprehensive studies on the effects of negation, complex sentences, clause dependency, and neutral candidates in the course of DDI extraction from biomedical articles. Results Our study proposes clause dependency features and a number of features for identifying neutral candidates as well as negation cues and scopes. Furthermore, our experiments indicate that the proposed features significantly improve the performance of the relation extraction task combined with other kernel methods. We characterize the contribution of each category of features and finally conclude that neutral candidate features have the most prominent role among all of the three categories. PMID:27695078

  6. Reaction Mechanism for m- Xylene Oxidation in the Claus Process by Sulfur Dioxide

    KAUST Repository

    Sinha, Sourab

    2015-09-24

    In the Claus process, the presence of aromatic contaminants such benzene, toluene, and xylenes (BTX), in the H2S feed stream has a detrimental effect on catalytic reactors, where BTX form soot particles and clog and deactivate the catalysts. Among BTX, xylenes are proven to be most damaging contaminant for catalysts. BTX oxidation in the Claus furnace, before they enter catalyst beds, provides a solution to this problem. A reaction kinetics study on m-xylene oxidation by SO2, an oxidant present in Claus furnace, is presented. The density functional theory is used to study the formation of m-xylene radicals (3-methylbenzyl, 2,6-dimethylphenyl, 2,4-dimethylphenyl, and 3,5-dimethylphenyl) through H-abstraction and their oxidation by SO2. The mechanism begins with SO2 addition on the radicals through an O-atom rather than the S-atom with the release of 180.0-183.1 kJ/mol of reaction energies. This exothermic reaction involves energy barriers in the range 3.9-5.2 kJ/mol for several m-xylene radicals. Thereafter, O-S bond scission takes place to release SO, and the O-atom remaining on aromatics leads to CO formation. Among four m-xylene radicals, the resonantly stabilized 3-methylbenzyl exhibited the lowest SO2 addition and SO elimination rates. The reaction rate constants are provided to facilitate Claus process simulations to find conditions suitable for BTX oxidation. © 2015 American Chemical Society.

  7. Justifying a revised voting rights act: The Guarantee Clause and the problem of minority rule

    OpenAIRE

    Chin, GJ

    2014-01-01

    In Shelby County v. Holder, the Supreme Court invalidated Section 4 of the Voting Rights Act of 1965, which required certain jurisdictions with histories of discrimination to "preclear" changes to their voting practices under Section 5 before those changes could become effective. This Article proposes that Congress ground its responsive voting rights legislation in the Constitution's Guarantee Clause, in addition to the Fourteenth and Fifteenth Amendments. The Court has made clear that the Gu...

  8. Conversion of Claus plants of Kurkuk-Iraq to produce hydrogen and sulfur

    Energy Technology Data Exchange (ETDEWEB)

    Naman, S.A.; Veziroglu, A. [Duhok Univ., Duhok City (Iraq). Dept. of Chemistry; International Association for Hydrogen Energy, Miami, FL (United States)

    2009-07-01

    Two Claus plants in Kirkuk, Iraq, convert hydrogen sulfide to elemental sulfur at a capacity of 2,200 tons/day. One of the plants is working at a capacity of only 400 tons/day with an old Claus process. The other uses a modified Claus sulfur recovery process with a capacity of 1800 tons/day. Both of the plants operate with low efficiency due to lack of maintenance. As such, the agricultural area surrounding Kirkuk is highly polluted. This paper described 2 pilot desulphurization plants that have been constructed inside the modified Claus plant. The first pilot plant is based on the flow system tube furnace reactor containing mixed titanium oxide/sulfide with a cold trap for sulfur separation and a bath of 30 per cent dithanolamine to separate and recycle hydrogen sulphide (H{sub 2}S) from hydrogen. The second pilot plant consists of a thermal diffusion ceramic rod inside a silica column containing zeolite 5A as a catalyst. This pilot plant also consists of a trap for continuous separation of sulfur and a system for separation of hydrogen from unreacted H{sub 2}S to recycle. The efficiency of conversion of H{sub 2}S to hydrogen and sulfur has been optimized as a function of catalyst type and mixture, temperature of furnace, flow rate of gas and reactor materials. The pilot plants were suitable with cadmium chalcogens catalysts to produce hydrogen, methane, ethane and sulphur, but with lower efficiency than H{sub 2}S decomposition only. The goal for the second pilot plant was to supply the heat using a solar energy concentrator instead of electricity. It was concluded that a hydrogen production plant in this part of Iraq will save a large area from polluted sulfur gas. The pilot plants can produce about 140 tons of hydrogen gas per day from these waste gases.

  9. [The physician's conscience, conscience clauses, and religious belief: A Catholic perspective].

    Science.gov (United States)

    Pellegrino, Edmund D

    2014-01-01

    This Essay explores how physicians may handle conflicts or conscience facing Roman Catholic Health practitioners regarding "human life" issues, especially through conscience clauses. In five parts, the author examines "first, why conscientious objection is so important in our day; second, the moral grounding for freedom in the exercise of conscience; third, the components of the physician's conscience; fourth, specific conflicts of conscience for Catholic physicians and institutions; and fifth, competing models of conflict resolution".

  10. On food security stocks, peace clauses, and permanent solutions after Bali:

    OpenAIRE

    Díaz-Bonilla, Eugenio

    2014-01-01

    This paper discusses potential solutions to the current impasse related to food security stocks, including a concrete proposal by the author on language to be included in the Agreement on Agriculture that may help comply with the mandate of the Bali Ministerial to find a solution in the next four years. The paper begins with an explanation of the background to the debate of the links between food security and WTO agricultural and trade negotiations and the interim solution (the peace clause) ...

  11. Implementation of MD5 Fast Crack Based on GPU Cluster%基于GPU集群实现MD5的快速破解

    Institute of Scientific and Technical Information of China (English)

    杨胜斌

    2013-01-01

    从单个GPU异构并行系统来看,其性能还是比较有限,文章阐述了基于GPU集群的CUDA架构实现过程,详细分析基于GPU集群进行MD5快速破解的编译过程,并对破解程序进行测试研究,对其运行结果进行测试和分析,探讨搭建GPU高性能计算集群及其进行MD5算法的快速破解的过程.

  12. Complex Clause Syntax in the Italian Classroom – the Learners Between Transfer and Interference

    Directory of Open Access Journals (Sweden)

    Darja Mertelj

    2013-12-01

    Full Text Available When teaching Italian as a foreign language, learners’ insecurities about using conjunctions and tenses in subordinate clauses can be noticed very early. Temporality, relative temporality and modality are signalled by Italian verb forms which function in a largely different (or apparently similar way in comparison to Slovene. If ‘true’ similarities can be exploited in the process of teaching/learning by means of a positive transfer, apparent ‘similarities’ and ‘differences’ between the two language systems should, on the other hand, be clarified to avoid negative transfer (interference. During the whole learning process language awareness should be developed, also through contrastive insights into the linguistic systems concerned. Taking as a starting point a text suitable for level B1, some problematic points are presented, for which a series of tasks can be suggested with the aim of helping the learner master complex clause syntax and develop language awareness. Key words: Italian, foreign/second language, complex clause, syntax, transfer, language awareness

  13. MD5和DES算法在市政网络平台中的应用%Municipal network platform based on md5 funtion and DES algrithm

    Institute of Scientific and Technical Information of China (English)

    邓中亮; 曹其可; 葛悦涛

    2011-01-01

    鉴于市政管理数据中包含大量敏感信息,为解决目前移动终端访问市政平台所存在的安全问题,采用MD5和DES算法,设计一移动通信中间件,对现有的网络进行改进以实现平台的安全机制.MD5算法用采实现身份认证过程,DES算法结合非对称加密和数字签名技术来保证信息的安全传输.该中间件可以以动态库的形式集成在客户端设备与市政管委的Web服务器上,因此可以不需要对现有资源进行较大的改动,以较小的代价达到安全性目标,大大降低部署的难度.%As the database of municipal administration contains large amounts of sensitive information, we designed this mobile middleware to optimized the exsiting platform and protected the sensitive data be attacted. This middleware is based on MD5 and DES algorithm. MD5 algorithm is used to implement the authentication process. DES algorithm combined with asymmetric encryption and digital signature to ensure the safety of information transmission. The middleware can be integrated in the client device and the Web server of the municipal in the form of dynamic libraries. You can achieve the security goals without need to carry out major changes to the existing resources, greatly reduced the difficulty of deployment.

  14. 基于CUDA架构的MD5并行分析算法研究%Research of MD5 Parallel Algorithm Based on CUDA

    Institute of Scientific and Technical Information of China (English)

    张伟; 陈田国; 陶志荣

    2009-01-01

    在介绍了CUDA(统一计算设备架构)架构的基础上,给出了一种CUDA架构上进行MD5摘要分析的并行算法.算法有效利用了GPU的并行性和CUDA架构的优势实现了较快的运算速度,测试结果显示优于CPU的算法.

  15. MD5算法与Web口令的安全传输%MD5 Algorithm and Security Transfer of Web Password

    Institute of Scientific and Technical Information of China (English)

    丁振国; 刘斌

    2004-01-01

    在研究了现存的采用单向散列算法对口令加密传输机制的缺点的基础上,提出了一种用MD5算法加密口令的改进方案,不仅实现简单,而且有效地提高了Web认证系统中口令传输的安全性.

  16. 基于MD5与Base64的混合加密算法%MD5-Base64 based hybrid encryption algorithm

    Institute of Scientific and Technical Information of China (English)

    罗江华

    2012-01-01

    介绍了一种基于MD5和Base64的混合加密算法,首先将明文MD5加密得到32位16进制密文,再将32位密文拆分成16个2位16进制数组,并转换成对应的二进制数,最后将16个二进制数组连接成一个128位的2进制数,采用Base64加密原理进行加密.该算法可以避免查询MD5散列值字典获取用户明文密码,更加有效地保证了用户的密码安全,最后给出了算法的PHP实现.%A MD5-Base64 baaed hybrid encryption algorithm was introduced, which encrypted plain text to 32-bit hexadecimal cipher text by MDS encryption, then split this 32-bit hexadecimal into 16 parts, and transformed them into binary Cor each part to join them together as a 128-bit binary, finally, encrypted the 128-bit binary array by using Base64 algorithm. This algorithm can avoid getting user's clear text password by querying MDS hash database, and protect user's password more effectively. This algorithm was described by PHP script language at the fourth section.

  17. Web开发中MD5摘要计算的应用——Struts技术实现

    Institute of Scientific and Technical Information of China (English)

    鲁屹华

    2008-01-01

    M05的全称是Message-Digest Algorithm 5(信息-摘要算法),在90年代初由MIT Laboratory for Computer Science和RSA Data Security Inc的Ronald L.Rivest开发出来,经MD2、MD3和MD4发展而来.本文首先介绍了MD5算法的概念.然后阐述了Java语言的java.security包对MD5算法的支持,并基于Sun公司Java 2平台企业版(J2EE)MVC框架Struts技术,针对B/S模式毕业设计选题系统中的学生基本信息注册模块所采用的MD5摘要计算作了详细介绍.

  18. 改造MD5让破解程序见鬼去

    Institute of Scientific and Technical Information of China (English)

    安美洪

    2005-01-01

    也许提到MD5时大家都很熟,但你真的了解它吗?虽然一般人是不用这样去寻根问底的,要用的时候直接去下载别人已编好的程序用就得了,但象我这样的好事者总想抓住点什么另类的东西——你有没有想过自己修改MD5,让网上漫天飞的MD5破解工具变得一无是处?要是有兴趣就往下看吧!

  19. 在飞速网用MD5值搜索PE系统

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    如果你要测试某PE系统.可是很多专门下载网站的资源链接都已经失效,幸好对于操作系统这类资源.很多网站都提供下载资源的MD5值。现在只要记下失效链接网站提供的资源MD5值,然后在地址栏输入http://www.raylile.com/zh—cn/files/6FA887054AB3EE91A5F542227FDC7493(“files/”后面的内容即为要搜索文件的MD5值).回车后即可跳转到该资源的下载链接中。

  20. 基于FPGA的MD5算法设计与实现%Design and Implementation of MD5 Algorithm Based on FPGA

    Institute of Scientific and Technical Information of China (English)

    王波涛; 韩国栋; 张效军

    2010-01-01

    MD5算法在网络安全的诸多方面都得到广泛的应用,在一些特殊场合要求计算具有高处理速度,低资源占用率的特点.文中首先介绍了MD5算法的发展历程和算法原理,然后描述了该算法在FPGA上实现的整体架构,分析了其各模块的功能,最后给出了基于Altera公司的Stratix Ⅱ GX系列FPGA的实现结果.通过实验结果可以看出基于FPGA的MD5算法实现具有较高的处理速度和较少的资源占用,并可对设计进行适当修改来实现其它的摘要算法,具有一定的实用价值.