WorldWideScience

Sample records for claudio ronco rinaldo

  1. Claudio Katz Claudio Katz

    Directory of Open Access Journals (Sweden)

    2010-10-01

    Full Text Available Claudio Katz nació en Argentina, en 1954. Es economista, integrante del Consejo Nacional de Ciencia y Tecnología de la República Argentina, profesor en la Universidad de Buenos Aires y director de varios proyectos de investigación. Es autor de numerosos textos de interpretación del capitalismo contemporáneo y de la crisis económica global. Participa activamente en los foros continentales de impugnación del libre-comercio, el endeudamiento externo y la militarización. Como integrante del EDI (Economistas de Izquierda ha publicado varios estudios sobre la coyuntura política y social de la Argentina y de América Latina. Entre sus publicaciones, se destacan sus libros El porvenir del socialismo (2004 y Las disyuntivas de la izquierda en América Latina (primera edición, 2008, que recibieron menciones honoríficas del Premio Libertador al Pensamiento Crítico, además de 'El rediseño de América Latina. Alca, Mercosur y Alba' (2006 y 'La economía marxista, hoy. Seis debates teóricos' (2009. En esta entrevista, concedida a la revista Trabalho, Educação e Saúde en junio de 2010, Katz expone algunas reflexiones sobre la realidad latinoamericana contemporánea, destacando la crítica al llamado 'nuevo desarrollismo', la perspectiva socialista del concepto de democracia y la vigencia del marxismo latinoamericano.Claudio Katz was born in Argentina in 1954. He is an economist, a member of the National Council for Science and Technology of Argentina, a professor at the University of Buenos Aires, and the director of several research projects. Katz is the author of numerous interpretation texts of contemporary capitalism and about the global economic crisis. He participates actively in continental forums on free trade disputes, external debt, and militarization. As a member of the of EDI (Leftist Economists, he has published several studies on the political and social situation of both Argentina and of Latin America. Among his publications

  2. Claudio Baglietto, Kant e l’antifascismo

    Directory of Open Access Journals (Sweden)

    Maria Chiara Pievatolo

    2011-07-01

    Full Text Available Depositato nell’Archivio Marini, il documento contiene un saggio incompiuto di Claudio Baglietto, filosofo normalista morto prematuramente nel 1940, che scelse l’esilio a Basilea a causa della sua obiezione di coscienza contro il servizio militare e contro il fascismo. Il saggio è preceduto da una presentazione di Aldo Capitini, suo compagno di studi e d’idee, e [...

  3. Rinaldo Küfferle e il mito di d'Annunzio

    Directory of Open Access Journals (Sweden)

    Maria Pia Pagani

    2014-07-01

    Full Text Available Questo contributo fa luce sul periodo di apprendistato della lingua italiana di Rinaldo Küfferle – svoltosi a Pontedera negli anni 1917-18 – durante il quale si consolida il suo mito per Gabriele d’Annunzio, di cui già aveva letto in patria molte opere in traduzione russa. Nel febbraio 1922 il giovane russo invia una toccante lettera al “divino maestro” al Vittoriale, unita a due suoi recenti componimenti poetici: raccontandogli la sua dolorosa vicenda di emigrazione e il suo fervido amore per la poesia, lo pone come guida letteraria in quella che sarà la sua feconda carriera di poeta, prosatore, librettista e traduttore.

  4. Consequências do ronco não-tratado Consequences of untreated snoring

    Directory of Open Access Journals (Sweden)

    Flávio José Magalhães da Silveira

    2010-06-01

    Full Text Available Em alguns estudos, o ronco tem sido associado com um risco aumentado de hipertensão, doença cardíaca isquêmica e acidente vascular encefálico. Os mecanismos são desconhecidos, mas provavelmente mediados pela apneia obstrutiva do sono. Contudo, a maioria dos roncadores não tem apneia do sono. Se o ronco, por si só, aumenta o risco de doença cardiovascular, isso ainda permanece controverso.In some studies, snoring has been associated with an increased risk of hypertension, ischemic heart disease and stroke. Although the mechanisms involved in these associations are unknown, they are probably mediated by obstructive sleep apnea. Nevertheless, most snorers do not have sleep apnea. Whether snoring itself increases the risk of cardiovascular disease remains controversial.

  5. Resultados preliminares do tratamento dos pacientes submetidos a radiofreqüência (baixa freqüência, somnoplastia no ronco e apnéia leve do sono

    Directory of Open Access Journals (Sweden)

    Dibbern Ralph S.

    2002-01-01

    Full Text Available Introdução: O ronco afeta 5 a 50% da população tornando-se um problema médico e social importante. O tratamento pode ser com medidas comportamentais, CPAP e cirúrgico. Objetivo: Avaliar os resultados pós-operatórios dos pacientes submetidos à radiofreqüência em palato. Forma de estudo: retrospectivo clínico. Material e método: 28 pacientes submetidos à radio-freqüência em palato, com diagnóstico de Ronco e Apnéia Leve do Sono. Observamos os resultados pós-operatórios através das Escalas de Epworth, Ronco e Sonolência diurna, complicações e percentual de melhora dos sintomas. A análise estatística foi pelo Mann Whytney Test. Resultados: 16 pacientes com melhora subjetiva do Ronco acima de 70% após a cirurgia; 26 pacientes mostraram redução significativa pelas Escalas, com complicações mínimas. Conclusão: Radio-freqüência é um método seguro e eficaz no tratamento do Ronco e Apnéia Leve do Sono. Resultados melhores serão obtidos com avaliação criteriosa pré e pós-operatórias.

  6. Nii kauge, kuid nii omane Brasiilia / Antonio Claudio Carvalho ; interv. Reet Varblane

    Index Scriptorium Estoniae

    Carvalho, Antonio Claudio

    2005-01-01

    Vestlus brasiilia kunstniku Antonio Claudio Carvalhoga 15. X, päeval pärast tema näituse avamist Kunstihoone galeriis. Kunstist, kunstnikest, endast, oma loomingust, kunsti tähendusest praeguses Brasiilias jm.

  7. Nii kauge, kuid nii omane Brasiilia / Antonio Claudio Carvalho ; interv. Reet Varblane

    Index Scriptorium Estoniae

    Carvalho, Antonio Claudio

    2005-01-01

    Vestlus brasiilia kunstniku Antonio Claudio Carvalhoga 15. X, päeval pärast tema näituse avamist Kunstihoone galeriis. Kunstist, kunstnikest, endast, oma loomingust, kunsti tähendusest praeguses Brasiilias jm.

  8. Fonoaudiologia X ronco/apneia do sono Speech therapy and snore and sleep apnea

    Directory of Open Access Journals (Sweden)

    Elisângela Barros Soares

    2010-04-01

    Full Text Available TEMA: sendo o sono necessário para termos energia, o ronco e a apneia do sono tornam-se obstáculos que acarretam problemas de saúde, como também problemas sociais, conjugais, escolares, entre outros. OBJETIVO: contribuir para um maior conhecimento do profissional fonoaudiólogo sobre as causas, consequências, diagnóstico e formas de tratamento da apneia obstrutiva do sono (AOS, a fim de favorecer a definição da conduta por este profissional, seja ela, encaminhar para um diagnóstico, tratar (por meio de fonoterapia essa patologia ou indicar o tratamento médico, seja ele, cirúrgico ou conservador. CONCLUSÃO: as possíveis alterações fonoaudiológicas encontradas nestes pacientes são: língua alargada apresentando hipotonia, palato mole com volume aumentado, dificuldade na alimentação devido ao aporte insuficiente de ar e ao bruxismo, possivelmente causado pela tensão e ansiedade decorrentes das noites mal dormidas. Outras alterações podem ser encontradas decorrentes do tratamento cirúrgico empregado em alguns casos, como a disfagia ou até mesmo alterações na fala e na ressonância da fala decorrente de uma uvulopalatoplastia. O enfoque do tratamento fonoaudiológico é a mioterapia dos músculos envolvidos, priorizando a musculatura palatal. Percebe-se que o fonoaudiólogo pode contribuir para amenizar os sintomas encontrados nestas patologias, proporcionando uma qualidade de vida melhor aos seus portadores.BACKGROUND: sleeping is necessary to provide us with energy. However, snoring and sleep apnea become obstacles that cause not only health problems, but also social, marital and educational issues. PURPOSE: contribute with a better understanding of the causes to the speech therapist, as well as the diagnosis and forms of treatment for Obstructive Sleep Apnea (OSA. Facilitate the definition of conduct by the therapist, be it a guide for a diagnosis, a treatment for that disease (through speech therapy or the indication of

  9. Ursamaior, by Mario Claudio: seven stars, a falling body

    Directory of Open Access Journals (Sweden)

    Mariana Caser da Costa

    2017-06-01

    Full Text Available In the year 2000, Portuguese writer Mario Claudio publishes Ursamaior, a novel that do not escape from his tendency of turning real data into fictional pieces. Together with Orion (2003, and Gemeos (2004, that book composes the “Trilogy of the Constellations”, according to Maria Theresa Abelha Alves. The first element of that triptych exposes several types of violence, among which an exhausting rape scene suffered by Jorge, the last star of Ursamaior constellation. Therefore, we will depart from that scene in order to reflect on the preponderant role of the playful element over the mourning body, basing our text on, for example, Walter Benjamin’s Origin of the German Baroque Drama. We will also focus on the intersemiotic game that establishes a dialogue between literature and other artistic languages, in this novel, notably cinema. Finally, the act of writing will be understood as a means of suturing torn souls and bodies, and also as a way of reorganizing chaos, highlighting the neobaroque characteristic of the pair mourning-game, and the self-reflection and the metalanguage as textual strategies not rarely evidenciated by mauroclaudian works.--- DOI: http://dx.doi.org/10.22409/abriluff.2017n18a411

  10. Developing Student Critical Thinking Skills through Teaching Psychology: An Interview with Claudio S. Hutz.

    Science.gov (United States)

    McCarthy-Tucker, Sherri

    2001-01-01

    Presents an interview with Claudio S. Hutz, who is dean of Instituto de Psicologia at Universidade Federal do Rio Grande do Sul in Porto Alegre, Brazil, where he has been teaching psychology since 1977. Discusses topics such as teaching psychology in Brazil and developing critical thinking skills. (CMK)

  11. Developing Student Critical Thinking Skills through Teaching Psychology: An Interview with Claudio S. Hutz.

    Science.gov (United States)

    McCarthy-Tucker, Sherri

    2001-01-01

    Presents an interview with Claudio S. Hutz, who is dean of Instituto de Psicologia at Universidade Federal do Rio Grande do Sul in Porto Alegre, Brazil, where he has been teaching psychology since 1977. Discusses topics such as teaching psychology in Brazil and developing critical thinking skills. (CMK)

  12. Claudio Moraga a passion for multi-valued logic and soft computing

    CERN Document Server

    Allende-Cid, Héctor

    2017-01-01

    The book is an authoritative collection of contributions by leading experts on the topics of fuzzy logic, multi-valued logic and neural network. Originally written as an homage to Claudio Moraga, seen by his colleagues as an example of concentration, discipline and passion for science, the book also represents a timely reference guide for advance students and researchers in the field of soft computing, and multiple-valued logic. .

  13. Gestalt Therapy and the Therapeutic Presence of Fritz Perls: An Interview with Claudio Naranjo

    OpenAIRE

    Ramírez Calderón, Iván; Escuela de Gestalt Claudio Naranjo Transformación Humana Colombia

    2010-01-01

    Como testigo y participe de excepción en el origen y desarrollo de la Terapia Gestalt, en esta entrevista Claudio Naranjo considera las características de esta forma de terapia, y lo hace a partir de su trabajo y de su encuentro personal con el hombre y la figura terapéutica de Fritz Perls. A lo largo de la entrevista se establece la base experiencial y los elementos del cambio terapéutico, junto con la actitud terapéutica, y la concepción holística de la persona; además se destacan los con...

  14. Gestalt Therapy and the Therapeutic Presence of Fritz Perls: An Interview with Claudio Naranjo

    Directory of Open Access Journals (Sweden)

    Iván Ramírez Calderón

    2011-01-01

    Full Text Available As exceptional witness and participant in the origin and development of the Gestalt therapy, Claudio Naranjo considers in this interview the cha- racteristics of this form of therapy, doing so from his work and his personal encounter with the man and the therapeutic figure of Fritz Perls. In the interview the experiential base and the therapeutic change elements are established, along with the therapeutic attitude, and the holistic conception of the person; also, the contrasts among academic psychology, the spiritual dimension of human beings, and the therapist’s intuition in the help rela- tionship are highlighted.

  15. Nuevos dibujos y dos lienzos inéditos de Claudio Coello

    Directory of Open Access Journals (Sweden)

    Zapata Fernández de la Hoz, Teresa

    2014-09-01

    Full Text Available Artist of great resources, always appreciated and cited with praise, Claudio Coello (1642-1693 is undoubtedly the great figure of Spanish painting in the second half of the seventeenth century. In this article a group of drawings preserved in the Madrid Casa de la Moneda (Mint and the Uffizi in Florence are attributed to the painter. Some of them are preparatory studies for secure works. Likewise presented are two unpublished paintings, one of them a splendid portrait of a member of a religious order.Artista de amplísimos recursos, siempre apreciado y citado con elogios, Claudio Coello (1642-1693 es sin duda la gran figura de la pintura española de la segunda mitad del siglo XVII. En este artículo se atribuyen al pintor un grupo de dibujos conservados en la Casa de la Moneda de Madrid y en los Uffizi, algunos preparatorios para obras seguras, a los que se añaden dos pinturas inéditas, entre ellas un espléndido retrato de un religioso.

  16. MADRIGALI GUERRIERI ET AMOROSI: O LIVRO OXÍMORO DE CLAUDIO MONTEVERDI

    Directory of Open Access Journals (Sweden)

    Maya Suemi Lemos

    2014-09-01

    Full Text Available A coletânea musical Madrigali Guerrieri et Amorosi, obra de maturidade do mais influente e revolucionário compositor do seicento, Claudio Monteverdi, se configura como materialização musical de uma poética dos contrários emblemática da estética literária maneirista e barroca. Indícios presentes na coletânea nos permitem identificar alguns dos principais marcos da genealogia desta poética dos contrários, assim como avançar hipóteses quanto ao sentido desta coletânea dentro da extensa obra musical de Monteverdi.                                 The musical collection known as Madrigali Guerrieri et Amorosi, a mature work of Claudio Monteverdi, the most influential and revolutionary composer of the seicento, represents a musical realization of a poetics of opposites which is emblematic of the Baroque and mannerist literary aesthetics. Indications present in the collection allow us to identify some of the principal landmarks of the genealogy of this poetics of opposites, as well as to present hypotheses about the meaning of this collection within the context of the extensive musical oeuvre of Monteverdi.  

  17. Rio de Janeirost Tallinna, 75 kraadi Celsiuse järgi / Antonio Claudio Carvalho ; tõlk. Reet Varblane

    Index Scriptorium Estoniae

    Carvalho, Antonio Claudio

    2006-01-01

    Juhendaja Antonio Claudio Carvalho Eesti Kunstiakadeemia üliõpilastele toimunud maalimeistriklassist "Ava oma silmad" ja lõpunäitusest Eesti Kunstiakadeemia galeriis. Enne näitust näitasid üliõpilased tööd, mida nad ise pidasid parimaks, kunstikriitik Heie Treierile

  18. Rio de Janeirost Tallinna, 75 kraadi Celsiuse järgi / Antonio Claudio Carvalho ; tõlk. Reet Varblane

    Index Scriptorium Estoniae

    Carvalho, Antonio Claudio

    2006-01-01

    Juhendaja Antonio Claudio Carvalho Eesti Kunstiakadeemia üliõpilastele toimunud maalimeistriklassist "Ava oma silmad" ja lõpunäitusest Eesti Kunstiakadeemia galeriis. Enne näitust näitasid üliõpilased tööd, mida nad ise pidasid parimaks, kunstikriitik Heie Treierile

  19. The Argonaut Myth in the Novel Alla cieca by Claudio Magris

    Directory of Open Access Journals (Sweden)

    Irena Prosenc

    2012-12-01

    Full Text Available The paper analyses the disintegration of identity and fragmentation of the narrative voice in the novel Alla cieca (Blindly, 2005 by Claudio Magris. Through the metaphor of sailing, the Trieste writer explores various aspects of narration, focusing on the autobiographical narrative; furthermore, he reflects on the multiple identity of the modern ego and on the destructive force of History, whose oppression has been perpetuated in the recent periods as well. The many issues addressed by the novel are connected by the continuous presence of the Argonaut myth, evoked by numerous intertextual references to the Argonautica by Apollonius Rhodius and to the Argonautica Orphica – a title which is, in contrast to that of the Hellenistic poem, not explicitly cited in the text.

  20. La voz de Claudio Rodríguez: propuesta para una escucha crítica

    Directory of Open Access Journals (Sweden)

    Alessandro Mistrorigo

    2012-05-01

    Full Text Available By starting from Claudio Rodríguez’s recordings, this paper suggests a way of listening voice in poetry pointing out some interesting aspects and problems that arise when establishing a new encounter not just between the poet’s voice and the listener, but also between the poet’s voice and the critic. The physical voice of a poet reading aloud his own poems re-projects and restructures constituting elements of poetic language (i.e. enjambment and caesura making evident variations between published version and vocalized one. Moreover, it always has a specific tone or a particular inflection, an accent or a personal prosody that contrubute to the listener’s comprehention of the text. Through the vocal execution the text is re-evoked always in a different way within a specific time and space as well as re-given a new relationship with the subject who is listening and understanding it.

  1. Consenso brasileiro de ronco e apneia do sono: aspectos de interesse aos ortodontistas Brazilian consensus of snoring and sleep apnea: aspects of interest for orthodontists

    Directory of Open Access Journals (Sweden)

    Cauby Maia Chaves Junior

    2011-02-01

    Full Text Available O objetivo deste artigo é explicitar o posicionamento das sociedades médicas que, reunidas, estabeleceram consenso sobre os parâmetros clínico-laboratoriais que envolvem os distúrbios respiratórios do sono, em especial o ronco e a síndrome da apneia obstrutiva do sono (SAOS. Os ortodontistas, que vêm ocupando gradativamente seu espaço em equipes multidisciplinares que atuam na área do sono humano, pouco conhecem sobre essa uniformização coordenada pela Associação Brasileira de Sono. Os trabalhos clínicos e as pesquisas científicas oriundos da Odontologia, e em particular da Ortodontia, também devem observar e seguir esses critérios de diagnóstico e tratamento estabelecidos pela comunidade médica brasileira.The objective of this article is to clarify the positions of the medical societies that have worked together to establish a consensus regarding the clinical and laboratory parameters involved in sleep-disordered breathing, particularly snoring and obstructive sleep apnea syndrome (OSAS. Orthodontists have gradually come to take part in multidisciplinary teams that act in the area of human sleep, but few know about the uniformity coordinated by the Brazilian Association of Sleep. Clinical and scientific studies from the field of dentistry (particularly orthodontics also must observe and follow these diagnosis and treatment criteria established by the Brazilian medical community.

  2. Violencia y maltrato en la familia romana y sus consecuencias : la adolescencia perdida de Tiberio Claudio

    Directory of Open Access Journals (Sweden)

    Milagros Moro Ipola

    2008-01-01

    Full Text Available El maltrato psicológico es todo aquel que se ejerce contra el normal desarrollo de la personalidad de un niño. Aunque actual, es una situación que niños y adolescentes han venido sufriendo a lo largo de los siglos y cuyas consecuencias se han dejado ver, ya no sólo durante su adolescencia, sino también en la edad adulta. Uno de los casos más significativos de maltrato hacia un menor es el que sufrió el emperador Tiberio ClaudioThe psychological maltreatment is whatever is exercised against the normal development of the personality of a child. Even though it is a current situation, children and teenagers have been suffering it over the centuries and its consequences can be seen not only during the adolescence but in their manhood. One of the most significant cases of maltreatment against a kid is that one Emperor Tiberius Claudius suffered.

  3. Looking through the Myth: the Figure of the Poet in Two Works by Claudio Magris

    Directory of Open Access Journals (Sweden)

    Irena Prosenc

    2015-04-01

    Full Text Available The paper analyses the figure of the poet in two works by the contemporary Italian writer Claudio Magris: in the short prose text Lei dunque capirà (You Will Therefore Understand and the novel Alla cieca (Blindly. In both works the figure of the poet is constructed through the eyes of the other as well as through the prism of mythological narration. In Lei dunque capirà, the image of the poet is shaped by Eurydice's voice, which filters the Orpheus myth, actualising and perhaps banalizing it. The novel, on the other hand, uses the Argonauts myth, intertwined with the Odysseus and Orpheus myths, to reflect on the nature of the narrating voice. The novel questions whether autobiographical narration can at all be reliable or whether it is to be considered – along with mythological narration – as nothing more than “réclame”, representing a deformed view of personal, historical and mythological memory. Magris questions the existence of a stable narrative voice in contemporary fiction, since it appears fragmented and unsure about its own identity. Both works include myth as the central element facilitating reflection on fundamental metaliterary issues. “Looking at the Myth” thus becomes “looking through the myth”, as well as, in Eurydice's narration, looking at a reflection: “I haven't seen myself, I do not know myself. But if you tell me about this, I shall know it and will be able to narrate it”.

  4. [Claudio Costa Casaretto M.D. (1914-1999) in Revista Medica de Chile].

    Science.gov (United States)

    Goic, A

    1999-10-01

    The work of Dr. Claudio Costa Casaretto covers a broad field in the history of Medicine in Chile. He contributed with the historical aspects in the Centennial issue of Revista Médica de Chile in July, 1972. He published 85 papers in this journal in a lapse of 20 years. In his works, he investigated about medical personalities with the highest relevance for Chilean medicine such as Dr. William Blest, graduated in Edinburgh and director of the first Medicine Course in Chile in 1833, the French obstetrician Dr. Lorenzo Sazie, first Dean of the Faculty of Medicine of the University of Chile in 1843 and Dr. Eloisa Díaz, first physician graduated in Chile and South America in 1887. He published the translation from Latin of Juan Ignacio Molina's verses "Elegies to smallpox", Chilean writer and erudite of the XVIII century. He also undertook the origins of Universidad de San Felipe (1737), Universidad de Chile (1842) and Pontificia Universidad Católica de Chile (1889) and the main educational events occurred in the Faculty of Medicine of the University of Chile, during the past century. He also published about the public health situation and sanitary care during the XIX century, about the conflict between private and public teaching and other political events of the past century. The work of Dr. Costa as a whole, is a real history textbook of Chilean Medicine. Dr. Costa and Dr. Enrique Laval are the most important Chilean medical historians of the XX century.

  5. La Terapia Gestalt y la presencia terapéutica de Fritz Perls: una entrevista a Claudio Naranjo.

    OpenAIRE

    Ramírez Calderón, Iván; Escuela de Gestalt Claudio Naranjo Transformación Humana Colombia

    2010-01-01

    Como testigo y participe de excepción en el origen y desarrollo de la Terapia Gestalt, en esta entrevista Claudio Naranjo considera las características de esta forma de terapia, y lo hace a partir de su trabajo y de su encuentro personal con el hombre y la figura terapéutica de Fritz Perls. A lo largo de la entrevista se establece la base experiencial y los elementos del cambio terapéutico, junto con la actitud terapéutica, y la concepción holística de la persona; además se destacan los con...

  6. La Terapia Gestalt y la presencia terapéutica de Fritz Perls: una entrevista a Claudio Naranjo.

    OpenAIRE

    Ramírez Calderón, Iván; Escuela de Gestalt Claudio Naranjo Transformación Humana Colombia

    2010-01-01

    Como testigo y participe de excepción en el origen y desarrollo de la Terapia Gestalt, en esta entrevista Claudio Naranjo considera las características de esta forma de terapia, y lo hace a partir de su trabajo y de su encuentro personal con el hombre y la figura terapéutica de Fritz Perls. A lo largo de la entrevista se establece la base experiencial y los elementos del cambio terapéutico, junto con la actitud terapéutica, y la concepción holística de la persona; además se destacan los con...

  7. Comentario en el aula del poema «Al ruido del Duero» de Claudio Rodríguez

    Directory of Open Access Journals (Sweden)

    María Antonia MEZQUITA FERNÁNDEZ

    2009-11-01

    Full Text Available RESUMEN: En el siguiente artículo se tratará de reflejar la experiencia en un aula de Educación Primaria para acercar a los niños la figura de Claudio Rodríguez y centrarnos en un comentario de su poema «Al ruido del Duero». El colegio elegido es el «Arias Gonzalo», de Zamora. Los niños participaron activamente a la hora de aportar ideas y de comentar el texto. Claudio Rodríguez se sentía fascinado y profesaba un gran amor a su tierra, a sus costumbres y al río Duero. Consideraba que los valores más relevantes del ser humano eran la sencillez, la solidaridad y la fraternidad y deseaba unirse y fundirse, primero, con el entorno natural y, después, con los hombres. En mi opinión, la respuesta de los alumnos fue positiva, ya que captaron la esencia de los versos y demostraron, con su colaboración, que los elementos usados para motivarles habían servido. Lo dejaron patente en las cartas, dibujos y poemas que realizaron posteriormente.ABSTRACT: The following article will try to show a commentary on the poem «Al ruido del Duero» by Claudio Rodríguez, from Zamora. The school which was chosen is called «Arias Gonzalo»; it is in Zamora too. The pupils took part actively and their ideas contributed to comment the text. Claudio Rodríguez was fascinated and professed huge love for the place where he was born, the customs of his province and The Duero River. He believed that the most important human values were simplicity, solidarity and brotherhood. First of all, he wished to be bound to nature. As far as mankind is concerned, he always desired to be joined together. In my opinion, the pupils answered positively and they understood the essence of the verses. They all proved that the elements for motivating them were useful. Then, they showed it clearly by drawing pictures, writing letters and poems.

  8. Don Claudio Sánchez Albornoz. El historiador y su obra

    Directory of Open Access Journals (Sweden)

    Serafín DE TAPIA

    2009-08-01

    Full Text Available Avila fue uno de los primeros lugares de España donde se realizó una manifestación a favor de la República. Corrían los últimos días de junio de 1869 y los sectores más progresistas del país, los republicanos, habían intensificado su movilización a raíz de la Promulgación de la Constitución de 1869, que reconocía que la monarquía era la forma de gobierno de la Nación española (art. 33. En Avila dimiten nueve concejales y los que siguen en sus puestos solicitan infructuosamente armas para los Voluntarios de la Libertad1, con cuyo apoyo pensaban los regidores mantener el espíritu de La Gloriosa. Eran tiempos agitados: los ultraconservadores carlistas se vuelven a alzar en partidas, lo que mueve al Comité Republicano de Avila a solicitar, en agosto de 1869, licencia del Ayuntamiento para «crear una fuerza aparte de su mismo partido, compuesta de cien o más hombres». Se deniega la autorización y además, meses después, el Gobierno central, cada vez más moderado procede a desarmar a los Voluntarios de la Libertad, como se estaba haciendo en todo el país; enterados los regidores del hecho consumado de la disolución de las Milicias urbanas se convoca el 6 de octubre sesión extraordinaria del Ayuntamiento para examinar el asunto. Un regidor lleva la voz cantante proponiendo a sus colegas dimitir en bloque como protesta: es D. Lucio Sánchez Albornoz, ascendiente directo de D. Claudio (era su tío-abuelo. La propuesta no fue secundada y ocho días después se recibe en el Ayuntamiento un oficio del Sr. Gobernador suspendiendo de su cargo de regidor a Sánchez Albornoz e imponiéndole una multa de 20 escudos (el salario mensual de un peón «con motivo de no haberse prestado a jurar la Constitución de 1869

  9. Geografía y nación. Claudio Gay y la primera representación cartográfica de Chile

    Directory of Open Access Journals (Sweden)

    Sagredo Baeza, Rafael

    2009-06-01

    Full Text Available This work considers the cartographic work that French naturalist Claudio Gay completed after he was hired by the Chilean government in 1830 to explore, recognize and study Chile’s territory and its resources. All of these made the first national cartography of the country possible. Claudio Gay’s cartographic contribution is valued in the context of the relationships between science and power and his maps are interpreted both as essential instruments for state administration and as tools for territorial integration and sovereignty purposes.

    El trabajo aborda la obra cartográfica del naturalista de origen francés Claudio Gay quién, contrado por el gobierno chileno en 1830 para explorar, reconocer y estudiar el territorio chileno y sus recursos, terminó preparando la primera cartografía de carácter nacional del país. El quehacer geográfico de Gay es apreciado en el contexto de las relaciones entre ciencia y poder, y sus mapas interpretados como un instrumento esencial de la administración estatal en cuanto herramienta para la integración territorial y el ejercicio de la soberanía.

  10. Ronco habitual e apnéia obstrutiva observada em adultos: estudo de base populacional, Pelotas, RS Habitual snoring and obstructive sleep apnea in adults: population-based study in Southern Brazil

    Directory of Open Access Journals (Sweden)

    Ricardo B Noal

    2008-04-01

    Full Text Available OBJETIVO: Estimar a prevalência de ronco habitual e apnéia obstrutiva observada e fatores associados. MÉTODOS: Estudo transversal com amostra representativa de 3.136 adultos, com 20 anos ou mais, residentes em Pelotas, Rio Grande do Sul, em 2005. Informações sobre os desfechos e variáveis demográficas, socioeconômicas, comportamentais e antropométricas foram coletadas por meio de questionário. A análise estatística bruta e ajustada foi realizada utilizando-se teste exato de Fisher ou qui-quadrado de tendência linear e regressão de Poisson, respectivamente. RESULTADOS: A prevalência encontrada de ronco habitual foi de 50,5% (IC 95%: 48,1;52,8 e de apnéia obstrutiva de 9,9% (IC 95%: 8,7;11,2. Na análise ajustada, o relato de ronco foi maior nos homens (Razão de Prevalências - RP=1,25; IC 95%: 1,16;1,34, nos idosos (RP=1,62; IC 95%: 1,46;1,80, nos tabagistas (RP=1,15; IC 95%: 1,07;1,25, nos alcoolistas (RP=1,17; IC 95%: 1,03;1,31 e nos obesos (RP 1,71, IC95% 1,55;1,88. O relato de apnéia obstrutiva foi maior nos homens (RP=2,05; IC 95%: 1,67;2,52, nos idosos (RP=2,23; IC 95%: 1,64;3,03, nos tabagistas (RP=1,60; IC 95%: 1,25;2,05 e nos obesos (RP=2,61; IC 95%: 1,97;3,47. CONCLUSÕES: Ronco habitual e apnéia obstrutiva foram sintomas comuns na população estudada. Fatores de risco conhecidos como sexo masculino e idade entre quarta e quinta décadas de vida não são modificáveis. Entretanto, tabagismo, alcoolismo e obesidade também associados aos desfechos, devem ser identificados e tratados na população geral.OBJECTIVE: To estimate the prevalence of habitual snoring and obstructive sleep apnea and their factors associated. METHODS: Cross-sectional study with a representative sample comprising 3,136 adults (>20 years living in the city of Pelotas, Southern Brazil, in 2005. A questionnaire was used to collect information on demographic, socioeconomic, behavioral and anthropometric variables and outcomes. Crude and adjusted

  11. Caracterização dos distúrbios de sono, ronco e alterações do sistema estomatognático de obesos candidatos à Cirurgia Bariátrica

    Directory of Open Access Journals (Sweden)

    Roberta Mores

    2017-03-01

    Full Text Available Introdução: Indivíduos obesos apresentam algumas características peculiares das estruturas que podem comprometer as funções do sistema estomatognático. Objetivo: Caracterizar estruturas e funções do sistema estomatognático, distúrbios de sono e ronco em obesos mórbidos candidatos à gastroplastia. Materiais e métodos: amostra constituída por 28 indivíduos, idade entre 22 e 65 anos, candidatos à cirurgia bariátrica. Avaliou-se o sistema estomatognático, aplicou-se Escala de Sonolência de EPWORTH e questionário de Qualidade de Vida de Pittsburgh. Resultados: Apresentara-se alteradas a morfologia (53,7% e postura da língua (32,1%, circunferência de pescoço aumentada (96,4% e Mallampati entre classe III e IV (85,8%. Referente à Escala de Sonolência de EPWORTH, 17,9% apresentaram alterações. Em relação aos aspectos do sono e ronco, 71,5% dos pacientes declararam roncar, 50% referiram falta de ar durante o sono e 75% sentem sonolência diurna. Em relação ao escore global do questionário de Qualidade de Vida de Pittsburgh, 60,7% dos pacientes classificaram o sono como ruim. Os escores do teste de Mallampati associaram-se ao índice de massa corporal e a dificuldade de sono na Escala de EPWORTH. Discussão: A intervenção em pacientes pré ou pós gastroplastia busca intervir nas estruturas e funções do sistema estomatognático, visando melhor correlação entre forma e função que podem contribuir para demais aspectos abordados pela equipe multidisciplinar e que promovam qualidade de vida. Conclusão: Indivíduos obesos mórbidos apresentam morfologia e postura da língua alteradas e circunferência do pescoço aumentada. Referem queixas relativas a dificuldades de sono, principalmente, presença de ronco, descontinuidade do sono noturno e sonolência diurna. ABSTRACT Characteristics of sleep disorders, snoring and disorders of stomatognatic system on obeses candidates for bariatric surgery Introduction: Obese

  12. Associações técnicas conjugadas para correção cirúrgica do ronco e SAOS (periférica Technical associations joined to snoring and SAOS (peripheral surgical corrections

    Directory of Open Access Journals (Sweden)

    Jeferson Sampaio D'Avila

    2003-01-01

    Full Text Available OBJETIVO: Com esta proposta de associação conjunta de técnicas cirúrgicas clássicas objetivamos oferecer de forma mais segura aquilo que cada uma especificamente apresenta de melhor, com a introdução da Microscopia Óptica em todos os procedimentos. MATERIAL E MÉTODO: Realizamos com critérios bem definidos o topodiagnóstico prático periférico, isolando apenas os classificados como Nível I de Fujita. Associamos três grupos específicos de técnica. Grupo A: LAUP (Kamami + U.P.F.P. Parcial (Fujita Modificado-FM. Grupo B: LAUP + Criptólise (Krespi + U.P.F.P. Parcial (Fujita Modificado. Grupo C: LAUP + Microcirurgia Tonsilas (Andréa/Dias + U.P.F.P. (FM. As indicações cirúrgicas de cada grupo são para: Grupo A: hipertrofia de úvula + rebaixamento de palato + ausência ou atrofia de tonsilas palatinas (TP. Grupo B: quadro anatômico semelhante ao Grupo A + hipertrofia de TP (grau I e II. Grupo C: hipertrofia de úvula e de TP (grau III+ redundância faríngea. No período de 38 meses, estamos com 60 casos operados, na proporção de: Grupo A: 20, Grupo B: 12 e Grupo C: 28. RESULTADOS: Houve melhora clínica em 46 pacientes (76,67%. Os melhores resultados foram detectados nos Grupos A e C. CONCLUSÃO: A seleção em grupos dos pacientes portadores de ronco e SAOS (periférica do nível I de Fujita, considerando-se parâmetros anátomo-clínicos, oferece-nos mais segurança na escolha adequada dos métodos de abordagem cirúrgica. Portanto, com esta proposta de associação de técnicas, estamos conseguindo melhorar nossos resultados e sugerimos que este esquema seja efetivado em outros serviços.AIM: Associating those classical surgical techniques, we intend to safely provide what each technique has to offer, introducing the Optical Microscopy in all procedures. MATERIAL AND METHOD: The practical peripheral topodiagnosis was made with well-defined criteria, isolating only the ones labeled as Level 1 by Fujita. Three specific types

  13. “Boletum medicatum”. La seta que mató al emperador Claudio / Boletum medicatum. The mushroom that killed the emperor Claudius

    Directory of Open Access Journals (Sweden)

    Joaquín Villalba Álvarez

    2009-06-01

    Full Text Available Resumen: Mucho se ha escrito a lo largo de los siglos sobre las circunstancias que rodearon la muerte del emperador romano Claudio (10 a. C. – 54 d. C.. El consenso general entre los historiadores antiguos que narran el episodio –Tácito, Suetonio y Dion Casio-, así como muchas otras referencias dispersas en la literatura latina nos llevan a pensar que su muerte se debió a una conspiración de su cuarta esposa, su sobrina Agripina, que le sirvió un plato de setas previamente envenenadas. Sin embargo, entre los estudiosos modernos hay quienes, como Grimm-Samuel, han barajado la posibilidad de que su muerte se debió a la ingesta (ya fuese premeditadamente, ya de manera accidental de setas venenosas, en concreto de la especie Amanita phalloides. Partiendo de diversos argumentos, ofrecemos nuestra opinión sobre el tema, que no difiere mucho de la que ofrecen los escritores de la Antigüedad.Summary: In the course of the centuries, many pages have been written on the circumstances surrounding the death of the Roman Emperor Claudius (10 BC – 54 AD. General agreement among ancient historians who relate us the story –Tacitus, Suetonius, Cassius Dio-, as well as the rest of scattered references in Latin literature induce us to think his death was due to his fourth wife’s conspiracy, his niece Agrippina, who served him a dish with previously poisoned mushrooms. Nevertheless, some of the scholars of our time, Grimm-Samuel for example, have considered the hypothesis that Claudius died because he ingested poisonous mushrooms (“either through criminal intent, or by sheer accident”, more specifically Amanita phalloides. Starting from different arguments, we offer our own point of view, which does not differ much from the ancient writers’ opinion.

  14. Mejoramiento de la integración sensorial en niñas y niños con discapacidad auditiva y visual de la Unidad Educativa Especial “Claudio Neira Garzón” Cuenca 2013

    OpenAIRE

    Pacheco Gutiérrez, Lourdes Verónica

    2014-01-01

    Un aula de Integración Sensorial es un espacio adaptado que se utiliza para proporcionar apoyo terapéutico positivo a los niños y niñas con discapacidad, favoreciendo la integración de sus sentidos y mejorando su calidad de vida. El presente proyecto se realizó en la Unidad Educativa Especial “Claudio Neira Garzón”, la población beneficiaria son los niños y niñas con discapacidad auditiva y visual. La propuesta básicamente se compone de tres grandes resultados los mismos que se alcanz...

  15. 迪普马与罗升的机电液整合之路——访迪普马全球销售总监Claudio Gazzaniga先生

    Institute of Scientific and Technical Information of China (English)

    张玲玲

    2009-01-01

    1952年以来意大利迪普马公司一直致力于液压领域的元件生产和系统集成的设计与制造。进入中国液压市场是2005年,与其它国外品牌比较起来进入中国市场较晚。但是,迪普马品牌不仅在短期之内扩大了品牌知名度还赢得了市场的认可。为此我们采访了迪普马全球销售总监Claudio Gazzaniga先生。

  16. Study of the musical dramaturgy in L'Orfeo, by Claudio Monteverdi, conducted from the tonal language of the composer : a proposal for a modern orchestration as dramaturgic appeal

    OpenAIRE

    Abel Luis Bernardo da Rocha

    2008-01-01

    Resumo: Este trabalho tem por objetivo apresentar a realização de uma PARTITURA CONTEMPORÂNEA DE EXECUÇÃO da ópera L'Orfeo - Favola in Musica, de Claudio Monteverdi, composta em 1607, apresentada aqui como uma transcrição historicamente informada, sugerindo a utilização de uma mescla de recursos e instrumentos contemporâneos combinados àqueles específicos da prática musical do repertório setecentista. Tal realização embasou-se na teoria e prática musical do século XVII. Num primeiro moment...

  17. PEREIRA, Claudio Corrêa. Minuanos/Guenoas. Os Cerritos da bacia da lagoa Mirim e as origens de uma nação pampiana. Porto Alegre: Fundação Cultural Gaúcha, 2008.

    Directory of Open Access Journals (Sweden)

    Rafael Milheira

    2012-09-01

    Full Text Available O livro publicado pelo Movimento Tradicionalista Gaúcho  –RS, intitulado:  Minuanos/Guenoas. Os Cerritos da bacia da lagoa Mirim e as origens de uma nação pampiana, de autoria de Claudio Corrêa Pereira é o resultado de sua monografia apresentada ao curso de  especialização em História da Formação Social, Política e Cultural do Rio Grande do Sul, da Universidade Católica de Pelotas. Este livro, dividido em duas partes e considerações finais, traz à tona uma temática há bastante tempo “adormecida” na arqueologia do sul do Brasil e que diz respeito às sociedades ameríndias que habitaram a região pampiana que envolve o sul do Estado do Rio Grande do Sul, o território uruguaio e o nordeste argentino. O tema diz respeito à história dos grupos Minuano/Guenoa, como ficaram conhecidos pela documentação etnohistórica e, ainda poderíamos, com a licença das terminologias utilizadas pelo autor, complementar também lembrando os grupos Charrua, que igualmente habitaram esta região, confundindo-se e mesclando-se aos primeiros ao longo da história colonial.

  18. [Claudio Galeno and the lateral ventricles].

    Science.gov (United States)

    Martínez, F; Decuadro-Sáenz, G

    2008-02-01

    Galen of Pergamon is considered one of the fathers of occidental medicine. Because of cultural and religious precepts at his time, many authors hypothesize that the anatomical concepts of Galen were derived from dissection of monkeys. In this paper, the authors analyzed the ventricular system, according to the anatomic and functional concepts described by Galen's early work. Knowing that his work was derived and or influenced from other preceding anatomists and physicians (specially Hipocrates of Cos), we present our investigation in two parts. In the first part, we present the influences of previous religious, philosophic, medical and anatomical theories over the galenic work. The "pregalenic era" can be divided in three periods: 1) the pretecnic era (ending in VI BC) in which the man have only a rudimentary knowledge of human anatomy, 2) the hellenistic science (from VI to III BC) and 3) the period comprised between III BC to Galenic period. In each of the three periods, we analyzed the neuroanatomic knowledge of the most important cultures.

  19. Täppispalkamine / Claudio Fernandez-Araoz

    Index Scriptorium Estoniae

    Fernandez-Araoz, Claudio

    2005-01-01

    10 peamist viga, mis tehakse uute töötajate tööle värbamisel ning vigade võimalikest lahendustest. Kommenteerivad Agu Vaher, Terje Tiiman ja Ille Einmann. Vt. samas: Kas teie firma vajaks uue inimese töölevärbamisel välist abi?; Midagi enamat kui vestlus - struktureeritud intervjuu; Kumba valida - armastusväärne tossike või kurjamist proff?

  20. Täppispalkamine / Claudio Fernandez-Araoz

    Index Scriptorium Estoniae

    Fernandez-Araoz, Claudio

    2005-01-01

    10 peamist viga, mis tehakse uute töötajate tööle värbamisel ning vigade võimalikest lahendustest. Kommenteerivad Agu Vaher, Terje Tiiman ja Ille Einmann. Vt. samas: Kas teie firma vajaks uue inimese töölevärbamisel välist abi?; Midagi enamat kui vestlus - struktureeritud intervjuu; Kumba valida - armastusväärne tossike või kurjamist proff?

  1. Reseña: Birocco, Carlos María & Cacciatore, Luis Claudio. El despegue del desarrollo tecnológico en la Provincia de Buenos Aires: industria saladeril, aprovechamiento del agua subterránea y mensuración de la tierra en el siglo XIX.

    Directory of Open Access Journals (Sweden)

    Facundo Roca

    2016-09-01

    Full Text Available El presente trabajo constituye una reseña de la obra El despegue del desarrollo tecnológico en la Provincia de Buenos Aires: industria saladeril, aprovechamiento del agua subterránea y mensuración de la tierra en el siglo XIX, de Carlos María Birocco y Luis Claudio Cacciatore. En esta reseña se realiza una revisión crítica del libro, identificando las fuentes y métodos empleados por los autores, las hipótesis centrales de la obra y los principales aportes y contribuciones al estudio del tema abordado. La obra comentada consiste en una investigación centrada en tres aspectos específicos del desarrollo científico-tecnológico de la segunda mitad del siglo XIX: la regulación de la actividad saladeril, el desarrollo de la hidrología y la mensuración y castración de tierras.

  2. Integrated design for sustainability : intelligence for eco-consistent products and services / Rinaldo C. Michelini, George L. Kovacs

    Index Scriptorium Estoniae

    Michelini, Rinaldo C.

    2003-01-01

    Kaanel ajak. ilmumisaeg 2002/2003. Autor tutvustab jätkusuutlikuks kasvuks ja arenguks vajalikke raamistikke (sotsiaal-majanduslik, poliitilis-juriidiline, tehnilis-teaduslik) ning esitab ideid kompleksse raamistiku loomiseks, mis toetab toodete, teenuste ja tehnoloogiliste protsesside elutsükli hindamist, s.h. vastavust ökoloogilistele nõudmistele. Tabelid

  3. Integrated design for sustainability : intelligence for eco-consistent products and services / Rinaldo C. Michelini, George L. Kovacs

    Index Scriptorium Estoniae

    Michelini, Rinaldo C.

    2003-01-01

    Kaanel ajak. ilmumisaeg 2002/2003. Autor tutvustab jätkusuutlikuks kasvuks ja arenguks vajalikke raamistikke (sotsiaal-majanduslik, poliitilis-juriidiline, tehnilis-teaduslik) ning esitab ideid kompleksse raamistiku loomiseks, mis toetab toodete, teenuste ja tehnoloogiliste protsesside elutsükli hindamist, s.h. vastavust ökoloogilistele nõudmistele. Tabelid

  4. Claudio Gigante - Dirk Vanden Berghe (eds., Il romanzo del Risorgimento

    Directory of Open Access Journals (Sweden)

    Marina Polacco

    2014-05-01

    Full Text Available A  lungo il dibattito storiografico sul Risorgimento è stato dominato dalla contrapposizione tra la retorica patriottica (la celebrazione della nascita della patria, il culto dei martiri e degli eroi risorgimentali e la denuncia dei limiti e delle inadempienze del processo di unificazione (la critica del Risorgimento come rivoluzione mancata, il riconoscimento della sostanziale immobilità delle strutture di potere, la questione meridionale. Parallelamente, in campo specificamente letterario il filone d’indagine più praticato è stato quello relativo alla narrativa ‘antirisorgimentale’ – sulla scia della celebre definizione di ‘romanzo antistorico’ coniata da Spinazzola a proposito di tre testi fondamentali nella rappresentazione del periodo storico in questione (e cioè I Vicerè, I vecchi e i giovani e Il gattopardo.

  5. Laenude lõksus / Dag Kirsebom, Claudio Zucchelli

    Index Scriptorium Estoniae

    Kirsebom, Dag

    2008-01-01

    Majandussurutise tingimustes ning olukorras, kus üle saja protsendi Eesti aastasest sisemajanduse kogutoodangust moodustavad laenud, peavad eestlased hakkama säästlikumalt elama, isiklikku finantsolukorda aitab kontrolli all hoida kuueelarve koostamine

  6. Laenude lõksus / Dag Kirsebom, Claudio Zucchelli

    Index Scriptorium Estoniae

    Kirsebom, Dag

    2008-01-01

    Majandussurutise tingimustes ning olukorras, kus üle saja protsendi Eesti aastasest sisemajanduse kogutoodangust moodustavad laenud, peavad eestlased hakkama säästlikumalt elama, isiklikku finantsolukorda aitab kontrolli all hoida kuueelarve koostamine

  7. LHC highlights from ATLAS - FRAPWS2016 conference - Claudio Luci

    CERN Document Server

    Luci, Claudio; The ATLAS collaboration

    2016-01-01

    I am going to give a talk about highlight from ATLAS. The conference is FRAP2016, it is a conference of astrophysics. My talk is the third one oon the first day, after a general talk and one about dark matter search at colliders (given by someone does not working in atlas or cms). There is not a talk given by a colleague from cms, so mine is the only one about lhc. I have prepared my slides thinking about a "general" public and not for a specialized audience like the one we use to give talks. I have 30 minutes, maybe I have too many slides but I can easily keep the ones about dark matter if I am going to run late.

  8. ABOUT OGLING: THE SET TABLE IN “MY PORTO”, BY MÁRIO CLAUDIO

    Directory of Open Access Journals (Sweden)

    Mariana Caser da Costa

    2014-04-01

    Full Text Available Mario Claudio’s bibliographic production, which spans varied genders, re­markably plays with literature’s ability of representing. In Meu Porto (My Porto, work published in 2001, the Portuguese writer fosters a walk around the burgh through an intersemiotic trip which invites different artistic lan­guages and ways of expression to the text, in a richly illustrated edition, with images based on the city he was born, that intends to reveal, through the biases of Porto’s landscape, art, mysticism, cultural and culinary tripeira tradition, a kind of a city report. What is interesting about the defended ideas in this article is how the author recreates his Porto by the pathway of the food, of the Portuguese rich table, by matching it with important peo­ple who had been in town. Therefore, literature can be read by a subjective speech which, highlighting traditional aspects of Portuguese culture, espe­cially food, reveals, in this dialog between the letters and the culinary art, images, flavors, and palatable stories to the taste of the text.

  9. Silicon alleviates Cd stress of wheat seedlings (Triticum turgidum L. cv. Claudio) grown in hydroponics.

    Science.gov (United States)

    Rizwan, M; Meunier, J-D; Davidian, J-C; Pokrovsky, O S; Bovet, N; Keller, C

    2016-01-01

    We investigated the potential role of silicon in improving tolerance and decreasing cadmium (Cd) toxicity in durum wheat (Triticum turgidum L. durum) either through a reduced Cd uptake or exclusion/sequestration in non-metabolic tissues. For this, plants were grown in hydroponic conditions for 10 days either in presence or absence of 1 mM Si and for 11 additional days in various Cd concentrations (0, 0.5, 5.0 and 50 μM). After harvesting, morphological and physiological parameters as well as elemental concentrations were recorded. Cadmium caused reduction in growth parameters, photosynthetic pigments and mineral nutrient concentrations both in shoots and roots. Shoot and root contents of malate, citrate and aconitate increased, while contents of phosphate, nitrate and sulphate decreased with increasing Cd concentrations in plants. Addition of Si to the nutrient solution mitigated these adverse effects: Cd concentration in shoots decreased while concentration of Cd adsorbed at the root cell apoplasmic level increased together with Zn uptake by roots. Overall, total Cd uptake decreased in presence of Si. There was no co-localisation of Cd and Si either at the shoot or at the root levels. No Cd was detected in leaf phytoliths. In roots, Cd was mainly detected in the cortical parenchyma and Si at the endodermis level, while analysis of the outer thin root surface of the plants grown in the 50 μM Cd + 1 mM Si treatment highlighted non-homogeneous Cd and Si enrichments. These data strongly suggest the existence of a root localised protection mechanism consisting in armoring the root surface by Si- and Cd-bearing compounds and in limiting root-shoot translocation.

  10. Ergonomic analysis of workplaces in the iron casting industrial pole in Claudio, Minas Gerais--Brazil.

    Science.gov (United States)

    Mottin, Artur Caron; de Miranda, Carlos A Silva; Pagnan, Caroline Salvan; Monken, Olavo Pena

    2012-01-01

    Brazil is currently recognized as the 10th largest producer of castings, and the city of Cláudio, MG is known worldwide as the "Greatest foundry and metallurgical pole in Latin America", with more than 80 companies. However, this large number of enterprises and increasing investments in product development has demanded an increase in manpower and working hours of workers in the sector, proportionally increasing the incidence of occupational related health problems like RSI (repetitive strain injury), WMSDs (work-related musculoskeletal disorders) and industrial accidents. This article aims to characterize the industry from previously conducted case studies to relate the main causes of occupational diseases and outline possible interventions through design, showing how this tool can contribute to improve the working environment, workplace, tools and equipment through ergonomics adjustments.

  11. Anna Maria Lorusso – Claudio Paolucci – Patrizia Violi (eds., Narratività. Problemi, analisi, prospettive

    Directory of Open Access Journals (Sweden)

    Marco Mondino

    2014-05-01

    Full Text Available La semiotica ha condotto la sua ricerca su forme testuali diverse considerando la narratività come il principio organizzatore di qualsiasi tipo di discorso e come vera e propria ipotesi interpretativa della cultura in generale. Un romanzo, una pubblicità, un’immagine, una città, una fotografia, una campagna di marketing, costituiscono vere e proprie configurazioni di senso che si manifestano attraverso diverse sostanze espressive e possono essere studiate come veri e propri testi analizzandone i modi di funzionamento, le stratificazione, le trasformazioni interne e le traduzioni in testi ulteriori. Non si tratta di una mera applicazione di una griglia teorica ad oggetti diversi, con il rischio di leggere indifferentemente le stesse cose ovunque, critica che è stata spesso mossa alla semiotica, piuttosto siamo in presenza di uno sguardo analitico in grado di costruire ipotesi interpretative proprio a partire dalla nozione di narratività che rappresenta il modo attraverso cui la semiotica arriva a concettualizzare il senso. La semiotica è per sua natura comparativa e trasversale e la sua specificità consiste nel guardare ad oggetti diversi facendone emergere di volta in volta le regole di funzionamento. 

  12. Distúrbios respiratórios durante o sono em crianças e adolescentes com sobrepeso, obesidade e roncos

    OpenAIRE

    Eliazor Campos Caixeta

    2004-01-01

    Aproximadamente um século após William Hill, em 1889, descrever de forma clara o quadro clínico clássico de crianças com apnéia do sono, Gastaut em 1966 descreve pela primeira vez a obstrução das vias aéreas superiores em adultos durante o sono, estudando as manifestações da Síndrome de Pickwick. Guillerminault et al. publica um artigo em 1976 com oito crianças as quais, apresentavam Síndrome das Apnéias Obstrutivas do Sono (SAOS). Os primeiros estudos envolvendo crianças obesas foram realiza...

  13. Silicon alleviates Cd stress of wheat seedlings (Triticum turgidum L. cv. Claudio) grown in hydroponics

    DEFF Research Database (Denmark)

    Rizwan, M.; Meunier, J. D.; Davidian, J. C.

    2016-01-01

    days either in presence or absence of 1 mM Si and for 11 additional days in various Cd concentrations (0, 0.5, 5.0 and 50 μM). After harvesting, morphological and physiological parameters as well as elemental concentrations were recorded. Cadmium caused reduction in growth parameters, photosynthetic...... pigments and mineral nutrient concentrations both in shoots and roots. Shoot and root contents of malate, citrate and aconitate increased, while contents of phosphate, nitrate and sulphate decreased with increasing Cd concentrations in plants. Addition of Si to the nutrient solution mitigated these adverse...

  14. LOMNITZ, Claudio. Los orígenes de nuestra supuesta homogeneidad: breve arqueología de la unidad nacional en México, p.17-36.

    OpenAIRE

    Lomnitz, Claudio

    2012-01-01

    Como a ideia de que o mexicano é membro de uma raça tornou-se legítima e popular? Este ensaio encara esta pergunta num marco comparado, observando desde o início, que a racionalização da identidade nacional - isto é, que a naturalização das diferenças nacionais - é uma estratégia comum, especialmente em estados demasiado frágeis para pretender formar uma identidade nacional coletiva a partir da igualização da lei. Contudo, o caso mexicano tem características pouco comuns, já que no México a i...

  15. El proyecto historiografico de Claudio Aquaviva y la construccion de la historia de la compania de Jesus en la nueva Espana a principios del siglo XVII

    National Research Council Canada - National Science Library

    Alcantara Bojorge, Dante A

    2009-01-01

    .... La orden deseaba contar con una historia pormenorizada de los diferentes lugares donde se habia establecido, asi como de sus provincias, con el objeto de elaborar la historia "general" del instituto...

  16. A correspondência de Cláudio Manuel da Costa dirigida aos acadêmicos Renascidos: informes de uma sociedade letrada = The correspondence of Claudio Manuel da Costa to Renascidos academic: information of a scholarly society

    Directory of Open Access Journals (Sweden)

    Moraes, Carlos Eduardo Mendes de

    2014-01-01

    Full Text Available Pretende-se discutir o tipo de correspondência produzida por Cláudio Manuel da Costa, na condição de membro da Academia Brasílica dos Renascidos, e comentá-la à luz da retórica antiga, apropriada pelos letrados entre os séculos XVI e XVIII como expressão modelar. Por intermédio desses documentos, comprovam-se a filiação do poeta à prática do academicismo, apresentam-se indícios de sua biografia e do domínio de dois estilos de escrita: a poética, estilo pelo qual é conhecido; e a acadêmica, empregada no exercício de suas atribuições nas associações letradas, confirmando-se suas ações tanto no quadro político quanto intelectual da época

  17. Estudio crítico-textual del libro III de NA de Claudio Eliano: normativismo y cuestiones de método para la edición de la obra

    Directory of Open Access Journals (Sweden)

    Manuela García Valdés

    2007-12-01

    Full Text Available The authoress of this paper develops a critical study on the main debatable passages of the text of the third book of De natura animalium (NA by Aelian. (III 2. 60.20-24; 3. 60.27; 18. 67.12-13; 21. 68.1; 22. 69.7-10; 23. 69.17-20; 26. 71.23; 26. 71.28-9; 38. 75.29; 42. 77.15; 44. 77.27. In the analysis she attempts to demonstrate, on the one hand, that the language of Aelian is still very poorly known, and how it is necessary to eliminate the conjectures and the alterations which had been arbitrarily made by earlier critics, and to prepare an edition of this work in order to understand well many key passages of his work. On the other hand, she exposes and applies the Textkritisch method, as the koiné literary texts need a rigourous and differenciated treatment that takes into account the period’s literary vogue, the evolution and language uses, namely in the phonetic, morphological and syntactic peculiarities of late Greek prose together with the author’s usage. Despite all those considerations, Aelian’s works has usually been judged and analysed through classical Greek standards. This research is a new contribution to the knowledge of the language of Aelian, of postclassical Greek and of ecdotics for Greek texts of the imperial period.

  18. Compact Solar Combisystem for an Apartment Building

    National Research Council Canada - National Science Library

    Bolonina, Alona; Rochas, Claudio; Kibure, Inese; Rosa, Marika; Blumberga, Dagnija

    2010-01-01

    ... _________________________________________________________________________________ Volume 4 29 Compact Solar Combisystem for an Apartment Building Alona Bolonina, Institute of Energy Systems and Environment, Riga Technical University, Claudio...

  19. Eesti Filharmoonia Kammerkoor esitab Monteverdi muusikat

    Index Scriptorium Estoniae

    2008-01-01

    Eesti Filharmoonia Kammerkoori ja Helsingi Barokkorkestri kontserdist Claudio Monteverdi loominguga 25. jaan. Rakvere Gümnaasiumis, 26. jaan. Tartu Jaani kirikus ja 27. jaan. Tallinnas Mustpeade majas

  20. Laulud armastusest ja sõjast / Kersti Inno

    Index Scriptorium Estoniae

    Inno, Kersti, 1954-

    2008-01-01

    Eesti Filharmoonia Kammerkoori ja Helsingi Barokkorkestri kontserdist Claudio Monteverdi loominguga 25. jaan. Rakvere Gümnaasiumis, 26. jaan. Tartu Jaani kirikus ja 27. jaan. Tallinnas Mustpeade majas

  1. Eesti Filharmoonia Kammerkoor esitab Monteverdi muusikat

    Index Scriptorium Estoniae

    2008-01-01

    Eesti Filharmoonia Kammerkoori ja Helsingi Barokkorkestri kontserdist Claudio Monteverdi loominguga 25. jaan. Rakvere Gümnaasiumis, 26. jaan. Tartu Jaani kirikus ja 27. jaan. Tallinnas Mustpeade majas

  2. Laulud armastusest ja sõjast / Kersti Inno

    Index Scriptorium Estoniae

    Inno, Kersti, 1954-

    2008-01-01

    Eesti Filharmoonia Kammerkoori ja Helsingi Barokkorkestri kontserdist Claudio Monteverdi loominguga 25. jaan. Rakvere Gümnaasiumis, 26. jaan. Tartu Jaani kirikus ja 27. jaan. Tallinnas Mustpeade majas

  3. Health Maintenance Organizations and the Elderly: Promises, Problems, and Prospects. Hearing before the Select Committee on Aging. House of Representatives, Ninety-Eighth Congress, Second Session (Boca Raton, Florida).

    Science.gov (United States)

    Congress of the U.S., Washington, DC. House Select Committee on Aging.

    This document contains the transcripts of witness testimony and prepared statements from the Congressional hearing called to explore the impact of the Health Maintenance Organization (HMO) on the health care system and on the elderly in particular. Opening statements are given from Representatives Dan Mica, Matthew Rinaldo, and Lawrence Smith.…

  4. Determination of Clinical and Demographic Predictors of Laboratory-confirmed Influenza with Subtype Analysis

    Science.gov (United States)

    2012-06-07

    Institutional Review Board and followed the human subject research guide- lines of that institution. Results Between November 14, 2007 and April 8...viruses A and B using real-time quantitative PCR. J Clin Microbiol 2001, 39(1):196–200. 12. Uyeki T, Prasad R, Vukotich C, Stebbins S, Rinaldo C, Ferng Y

  5. Violent Crime Against the Elderly: A New Jersey Perspective. Hearing before the Select Committee on Aging. House of Representatives, Ninety-Ninth Congress, First Session (Plainfield, NJ).

    Science.gov (United States)

    Congress of the U.S., Washington, DC. House Select Committee on Aging.

    This document contains testimony from a Congressional hearing held in New Jersey to examine violent crime against the elderly. Opening statements are presented from committee members Matthew J. Rinaldo, William J. Hughes, Christopher H. Smith, and Dan Mica. Four panels of witnesses testify: (1) two elderly victims of violent crime; (2) federal,…

  6. Tuning the cytotoxic properties of new ruthenium(III) and ruthenium(II) complexes with a modified bis(arylimino)pyridine Schiff base ligand using bidentate pyridine-based ligands : Topical issue in honor of Ivano Bertini. Guest editors Lucia Banci, Claudio Luchinat

    NARCIS (Netherlands)

    Garza-Ortiz, Ariadna; Maheswari, Palanisamy Uma; Lutz, Martin; Siegler, Maxime A.; Reedijk, Jan

    2014-01-01

    Synthesis, spectroscopy, characterization, structures, and cytotoxicity studies of 2,6-bis(2,6-diisopropylphenyliminomethyl)pyridine (LLL) ruthenium compounds are described. The starting compound [RuCl3(LLL)] has been fully characterized using IR spectroscopy, UV-vis spectroscopy, electrospray

  7. Tuning the cytotoxic properties of new ruthenium(III) and ruthenium(II) complexes with a modified bis(arylimino)pyridine Schiff base ligand using bidentate pyridine-based ligands : Topical issue in honor of Ivano Bertini. Guest editors Lucia Banci, Claudio Luchinat

    NARCIS (Netherlands)

    Garza-Ortiz, Ariadna; Maheswari, Palanisamy Uma; Lutz, Martin; Siegler, Maxime A.; Reedijk, Jan

    2014-01-01

    Synthesis, spectroscopy, characterization, structures, and cytotoxicity studies of 2,6-bis(2,6-diisopropylphenyliminomethyl)pyridine (LLL) ruthenium compounds are described. The starting compound [RuCl3(LLL)] has been fully characterized using IR spectroscopy, UV-vis spectroscopy, electrospray ioniz

  8. Genetics Home Reference: hereditary angiopathy with nephropathy, aneurysms, and muscle cramps syndrome

    Science.gov (United States)

    ... on PubMed Central Plaisier E, Chen Z, Gekeler F, Benhassine S, Dahan K, Marro B, Alamowitch S, Paques M, Ronco P. Novel COL4A1 mutations associated with HANAC syndrome: a role for the triple helical CB3[IV] domain. Am J Med Genet ...

  9. Muusikauudiseid maailmast / Nele-Eva Steinfeld

    Index Scriptorium Estoniae

    Steinfeld, Nele-Eva

    2014-01-01

    Lühisõnumeid maailmast: Claudio Abbado (1933-2014). Kuldne Grammy eesti muusikutele. Moskva Suure Teatri muusikajuhiks sai Tugan Sokhiev. Milwaukees röövitud stradivaarius leitud. "Jaapani Beethoveniks" nimetatud Mamoru Samuragochil oli variautor

  10. Anneli Remme soovitab : Armastuse ja sõja laulud / Anneli Remme

    Index Scriptorium Estoniae

    Remme, Anneli, 1968-

    2008-01-01

    Eesti Filharmoonia Kammerkoori ja Helsingi Barokkorkestri kontserdist Claudio Monteverdi loominguga 25. jaan. Rakvere Gümnaasiumis, 26. jaan. Tartu Jaani kirikus ja 27. jaan. Tallinnas Mustpeade majas, Euroraadio kontsert 29. jaan. Tallinna Metodisti kirikus

  11. Anneli Remme soovitab : Armastuse ja sõja laulud / Anneli Remme

    Index Scriptorium Estoniae

    Remme, Anneli, 1968-

    2008-01-01

    Eesti Filharmoonia Kammerkoori ja Helsingi Barokkorkestri kontserdist Claudio Monteverdi loominguga 25. jaan. Rakvere Gümnaasiumis, 26. jaan. Tartu Jaani kirikus ja 27. jaan. Tallinnas Mustpeade majas, Euroraadio kontsert 29. jaan. Tallinna Metodisti kirikus

  12. Muusikauudiseid maailmast / Nele-Eva Steinfeld

    Index Scriptorium Estoniae

    Steinfeld, Nele-Eva

    2014-01-01

    Lühisõnumeid maailmast: Claudio Abbado (1933-2014). Kuldne Grammy eesti muusikutele. Moskva Suure Teatri muusikajuhiks sai Tugan Sokhiev. Milwaukees röövitud stradivaarius leitud. "Jaapani Beethoveniks" nimetatud Mamoru Samuragochil oli variautor

  13. Nanobiotechnology in energy, environment and electronics methods and applications

    CERN Document Server

    Nicolini, Claudio

    2015-01-01

    Introduction: Present Challenges and Future Solutions via Nanotechnology for Electronics, Environment and Energy; Claudio NicoliniPart A: MethodsInfluence of Chromosome Translocation on Yeast Life Span: Implications for Long-Term Industrial Biofermentation; Jason Sims, Dmitri Nikitin, and Carlo V. BruschiPulsed Power Nanotechnologies for Disintegration and Breaking Up of Refractory Precious Metals Ores; Valentin A. Chanturiya and Igor Zh. BuninModeling of Software Sensors in Bioprocess; Luca Belmonte and Claudio NicoliniN

  14. National Computer Security Conference (15th) held in Baltimore, Maryland on October 13-16, 1992. Volume 2: Proceedings

    Science.gov (United States)

    1992-10-16

    126 Electronic Measurement of Software Sharing for Computer Virus Epidemiology Larry de La Beaujardiere, Department of Computer Science...E (f) (= 0 (times 2 f))) (IFF (= out in) (OR ( AMD (E (f) (= 0 (times 2 f))) (= out in)) (AND (NOT (E (f) (= 0 (times 2 f)))) (= out (not in...Democracy), Juan Maria Bandres Molet ( Spain , People’s Left), Rinaldo Bontempi (Italy, Party of the Democratic Left), Carlos Maria Bru Puron ( Spain

  15. Frode alla legge o frode della legge?

    OpenAIRE

    Salvatore Berlingò

    2011-01-01

    Il saggio riproduce con qualche variante il contenuto della voce “Fraude de ley” - che apparirà, in traduzione spagnola, nel Diccionario General de Derecho Canónico, dell’Instituto Martìn Azpilcueta - ed è destinato agli Studi in onore di Rinaldo Bertolino.SOMMARIO: 1 - “Fraus legis” e “fictio iuris” – 2. La frode della legge e la simulazione – 3. Il mendacio e la compromissione delle regole fondamentali dell&rs...

  16. JPRS Report, Science & Technology, Europe & Latin America.

    Science.gov (United States)

    1988-01-22

    Rex Malik; ZERO UN INFORMATIQUE, 31 Aug 87) 25 FACTORY AUTOMATION, ROBOTICS West Europe Seeks To Halt Japanese Inroads in Machine Tool Sector...ET TECHNIQUES, 10 Oct 87) 33 Briefs French Robot Base 38 MICROELECTRONICS Belgian-American Chip Cooperation (DE STANDAARD, 22 Sep 87) 39...INDUSTRIA OGGI in Italian Sep 87 p 85 [Interview with Rinaldo Piva, managing direstor of Ceramica Industriale Fer, by Luisella Acquati: "Italy Is

  17. Disease: H01249 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H01249 Ethylmalonic encephalopathy (EE) Ethylmalonic encephalopathy (EE) is an auto... Hahn SH, Leonard J, Rahman S, Dionisi-Vici C, Garavaglia B, Gasparini P, Zeviani M Ethylmalonic encephalopathy...D, Tiranti V A case of ethylmalonic encephalopathy with atypical clinical and biochemical presentation. Mol ..., Rinaldo P, Yamaguchi S Therapeutic trial in the first three Asian cases of ethylmalonic encephalopathy: response to riboflavin. J Inherit Metab Dis 24:870-3 (2001) ...

  18. Divine Performance

    DEFF Research Database (Denmark)

    Schneider, Magnus Tessing

    2006-01-01

    Essay on the Orpheus figure as a personification of the transcendent dimension of art, and how this motive has been treated in the philosophy of Marsilio Ficino as well as in four operas: Jacopo Peri's L'Euridice (1600), Claudio Monteverdi's L'Orfeo (1607), C. W. Gluck's Orfeo ed Euridice (1762) ...

  19. Diagnosis of AIDS-Related Intestinal Parasites

    Science.gov (United States)

    1988-01-07

    Peru), Claudio F. Lanata (Instituto de Investigacion Nutricional , Lima, Peru) and Irene Perez-Schael (Instituto de Biomedicina, Caracas, Venezuela) (15...above) and Homero Martinez, M.D., Instituto National de la Nutricion , Mexico City. In this study, 53 children with at least one microscopic stool

  20. Historien er ikke slut

    DEFF Research Database (Denmark)

    Thurah, Thomas

    , Seamus Heaney, Stefan Heym, Peer Hultberg, Per Højholt, Imre Kertész, Jan Kjærstad, Ivan Klíma, Jaan Kross, Siegfried Lenz, Claudio Magris, Antonio Muñoz Molina, Cees Nooteboom, Ljudmila Petrusjevskaja, Christoph Ransmayr, Klaus Rifbjerg, Salman Rushdie, José Saramago, Peter Seeberg, Tage Skou...

  1. Cent’anni dopo: la Grande Guerra e la cultura politica britannica

    Directory of Open Access Journals (Sweden)

    Maria Chiara Pievatolo

    2014-12-01

    Full Text Available Claudio Palazzolo ha scelto di pubblicare ad accesso aperto il suo intervento al convegno L’Italia e l’Europa di fronte alla Grande Guerra, dedicato a La Grande Guerra e la cultura politica britannica. Il suo testo, depositato nell’archivio Marini, è a...

  2. R-matrix Methods with an application to 12C(alpha,gamma)16O

    OpenAIRE

    Brune, Carl R.

    2010-01-01

    Comment: 7 pages. Published in the Proceedings of the Fifth European Summer School on Experimental Nuclear Astrophysics, Santa Tecla, Sicily, Italy, 20-27 September 2009, Editors Claudio Spitaleri, Claus Rolfs, and Rosario Gianluca Pizzone, AIP Conference Proceedings number 1213 (AIP, New York, 2010), pp. 35-41

  3. Il capitale monopolistico di Baran e Sweezy e la teoria marxiana del valore

    Directory of Open Access Journals (Sweden)

    Claudio Napoleoni

    2015-03-01

    Full Text Available The text is the transcript of a lecture given on 12 May 1973 by Claudio Napoleoni, as part of a course on Economic and financial policy at the University of Turin. The lecture, edited by Riccardo Bellofiore, concerns Baran and Sweezy’s Monopoly Capital and its relation to Marx’s theory of value.

  4. Crisi e centralizzazione del capitale finanziario

    Directory of Open Access Journals (Sweden)

    Emiliano Brancaccio

    2015-03-01

    Full Text Available The text is the transcript of a lecture given on 12 May 1973 by Claudio Napoleoni, as part of a course on Economic and financial policy at the University of Turin. The lecture, edited by Riccardo Bellofiore, concerns Baran and Sweezy’s Monopoly Capital and its relation to Marx’s theory of value.

  5. Petras tunge

    DEFF Research Database (Denmark)

    Thurah, Thomas

    hovedstæder, små og store metropoler, hvor historien har sat sig tydelige spor og endnu gør det for magtfuldt og tilsyneladende tvivlløst at bevidne en ny tingenes orden. Litteraturen skrives af bl.a. Martin Amis, Hanif Kureishi, Marcel Beyer, Günter Grass, Milan Kundera, Cees Nooteboom, Aldo Busi, Claudio...

  6. Kaitstud magistritööd, 1. juuni 2012

    Index Scriptorium Estoniae

    2013-01-01

    Oma töid kaitsesid Claudio Julio Rodriguez Higuera, Davi William Ferreira Gomes, Karlina Vaivade, Mohamed Gamal Abdelmeged Elmaayergy, Sigita Tamošauskaite, Eduardo Chávez Herrera, Tyler James Bennett, Felipe Cuervo Restrepo, Julia Popova, Anastasiia Sidielnik, Thomas Mark Boyle, Mirjam Männik, Sandra Preiman, Tamara Stojanovic

  7. Acknowledgements

    NARCIS (Netherlands)

    Hendrix, H.

    In February 2009, the University of Utrecht welcomed Claudio Magris as its first writer-in-residence, in a new and ambitious programme launched in order to bring the Utrecht academic community in close contact with some of the world’s finest and most accomplished poets and writers. While at Utrecht

  8. Davanti alla legge. Letteratura e diritto

    NARCIS (Netherlands)

    Magris, Claudio

    Durante la sua permanenza in quanto scrittore ospite all’Università di Utrecht nel febbraio 2009, Claudio Magris pronunciò – in inglese – la prima ‘Romano Guarnieri Lecture in Italian Studies’, scegliendo come tema il rapporto fra letteratura e diritto. Nella sua prolusione Magris afferma che la

  9. Acknowledgements

    NARCIS (Netherlands)

    Hendrix, H.

    2009-01-01

    In February 2009, the University of Utrecht welcomed Claudio Magris as its first writer-in-residence, in a new and ambitious programme launched in order to bring the Utrecht academic community in close contact with some of the world’s finest and most accomplished poets and writers. While at Utrecht

  10. Davanti alla legge. Letteratura e diritto

    NARCIS (Netherlands)

    Magris, Claudio

    2009-01-01

    Durante la sua permanenza in quanto scrittore ospite all’Università di Utrecht nel febbraio 2009, Claudio Magris pronunciò – in inglese – la prima ‘Romano Guarnieri Lecture in Italian Studies’, scegliendo come tema il rapporto fra letteratura e diritto. Nella sua prolusione Magris afferma che la let

  11. Sisustusgiidi uudised / Mari Masso

    Index Scriptorium Estoniae

    Masso, Mari

    2007-01-01

    Uut elutoa mööblit Eesti poodides - diivan Janno Roosilt ja Andres Labilt, tugitool Patricia Urquiolalt, Zaha Hadidi disainitud laud "Aqua", Mareo Marani pöördjalaga tool "Free" ja erinevate mustritega lauad disainistuudiolt Archivolto (disainerid Claudio Dondoli ja Marco Pocci). Lk. 58 Ell-Maaja Randküla kommentaar

  12. Bagatellid : maailm / Mirjam Tally

    Index Scriptorium Estoniae

    Tally, Mirjam, 1976-

    2007-01-01

    Lahkus Luciano Pavarotti. CD-plaat tähistas 25 aasta juubelit. Claudio Abbado on muusikamaailma suuremast saginast pisut tagasi tõmbunud. Robot mängib löökpille. Ooperikardinate taga: läbipõlenud lauljad

  13. Muusikauudiseid maailmast / Nele-Eva Steinfeld

    Index Scriptorium Estoniae

    Steinfeld, Nele-Eva

    2016-01-01

    Lühisõnumeid maailmast: Suri Nikolaus Harnoncourt. Grammy selleks aastaks jagatud. Claudio Abbado pärand liigub Berliini. Piotr Anderszewski võtab aja maha. Polar Music Prize Cecilia Bartolile. Lahkus USA helilooja Steven Stucky. Händeli kantaadi seni tundmatu versioon

  14. UEFA ametnik laitis staadionide seisukorda / Nils Niitra

    Index Scriptorium Estoniae

    Niitra, Nils, 1975-

    2004-01-01

    UEFA noorte- ja amatöörjalgpalli projektijuht Claudio Negroni andis Tartu ja selle lähiümbruse staadionidele ebarahuldava hinde. Tamme staadionil tehakse 16 miljonit krooni maksev remont, et seal saaks 2007.a. toimuda 19-aastaste noormeeste Euroopa jalgpalli meistrivõistluste finaalturniir

  15. Kunstnikuks pürgija vajab paari õigeaegset impulssi / Kaido Ole, Eva Unt

    Index Scriptorium Estoniae

    Ole, Kaido

    2006-01-01

    Antonia Claudio Carvalho meistriklass "Ava oma silmad/Open Your Eyes" 23.-27. I ja näitus 27. I-9. II Eesti Kunstiakadeemia galeriis. Meistriklassist vestlesid EKA maaliosakonna juhataja Kaido Ole ja maalieriala III kursuse üliõpilane Eva Unt

  16. Uudiseid maailmast / Nele-Eva Steinfeld

    Index Scriptorium Estoniae

    Steinfeld, Nele-Eva

    2013-01-01

    Claudio Abbado kuulutati eluaegseks senaatoriks. Erkki-Sven Tüüri uudisteos "Peregrinus ecstaticus" Helsingis, Stockholmis renoveeritakse ooperimaja. Minnesota orkestri probleemid jätkuvad. "BBC Promsi" festivali edukas suvi. Titanicu pardal kõlanud viiul läheb näitusele ja oksjonile. Suri Ray Dolby

  17. Estudo do comportamento rotatório induzido por diferentes substancias em ratos com lesão induzida por 6-OHDA no feixe prosencefalico medial (FPM) /

    OpenAIRE

    Gregorio,Michele Lima

    2007-01-01

    Orientador : Claudio da Cunha Co-orientadora : Maria Aparecida B.F. Vidal Dissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia. Defesa: Curitiba, 2007 Inclui bibliografia

  18. Uudiseid maailmast / Nele-Eva Steinfeld

    Index Scriptorium Estoniae

    Steinfeld, Nele-Eva

    2013-01-01

    Claudio Abbado kuulutati eluaegseks senaatoriks. Erkki-Sven Tüüri uudisteos "Peregrinus ecstaticus" Helsingis, Stockholmis renoveeritakse ooperimaja. Minnesota orkestri probleemid jätkuvad. "BBC Promsi" festivali edukas suvi. Titanicu pardal kõlanud viiul läheb näitusele ja oksjonile. Suri Ray Dolby

  19. Kunstnikuks pürgija vajab paari õigeaegset impulssi / Kaido Ole, Eva Unt

    Index Scriptorium Estoniae

    Ole, Kaido

    2006-01-01

    Antonia Claudio Carvalho meistriklass "Ava oma silmad/Open Your Eyes" 23.-27. I ja näitus 27. I-9. II Eesti Kunstiakadeemia galeriis. Meistriklassist vestlesid EKA maaliosakonna juhataja Kaido Ole ja maalieriala III kursuse üliõpilane Eva Unt

  20. Sisustusgiidi uudised / Mari Masso

    Index Scriptorium Estoniae

    Masso, Mari

    2007-01-01

    Uut elutoa mööblit Eesti poodides - diivan Janno Roosilt ja Andres Labilt, tugitool Patricia Urquiolalt, Zaha Hadidi disainitud laud "Aqua", Mareo Marani pöördjalaga tool "Free" ja erinevate mustritega lauad disainistuudiolt Archivolto (disainerid Claudio Dondoli ja Marco Pocci). Lk. 58 Ell-Maaja Randküla kommentaar

  1. UEFA ametnik laitis staadionide seisukorda / Nils Niitra

    Index Scriptorium Estoniae

    Niitra, Nils, 1975-

    2004-01-01

    UEFA noorte- ja amatöörjalgpalli projektijuht Claudio Negroni andis Tartu ja selle lähiümbruse staadionidele ebarahuldava hinde. Tamme staadionil tehakse 16 miljonit krooni maksev remont, et seal saaks 2007.a. toimuda 19-aastaste noormeeste Euroopa jalgpalli meistrivõistluste finaalturniir

  2. Bagatellid : maailm / Mirjam Tally

    Index Scriptorium Estoniae

    Tally, Mirjam, 1976-

    2007-01-01

    Lahkus Luciano Pavarotti. CD-plaat tähistas 25 aasta juubelit. Claudio Abbado on muusikamaailma suuremast saginast pisut tagasi tõmbunud. Robot mängib löökpille. Ooperikardinate taga: läbipõlenud lauljad

  3. Muusikauudiseid maailmast / Nele-Eva Steinfeld

    Index Scriptorium Estoniae

    Steinfeld, Nele-Eva

    2016-01-01

    Lühisõnumeid maailmast: Suri Nikolaus Harnoncourt. Grammy selleks aastaks jagatud. Claudio Abbado pärand liigub Berliini. Piotr Anderszewski võtab aja maha. Polar Music Prize Cecilia Bartolile. Lahkus USA helilooja Steven Stucky. Händeli kantaadi seni tundmatu versioon

  4. Kaitstud magistritööd, 1. juuni 2012

    Index Scriptorium Estoniae

    2013-01-01

    Oma töid kaitsesid Claudio Julio Rodriguez Higuera, Davi William Ferreira Gomes, Karlina Vaivade, Mohamed Gamal Abdelmeged Elmaayergy, Sigita Tamošauskaite, Eduardo Chávez Herrera, Tyler James Bennett, Felipe Cuervo Restrepo, Julia Popova, Anastasiia Sidielnik, Thomas Mark Boyle, Mirjam Männik, Sandra Preiman, Tamara Stojanovic

  5. Polisomnographic findings on children with laryngopathies

    OpenAIRE

    2006-01-01

    O exame diagnóstico padrão-ouro para SAOS na infância é a polissonografia. Quando pode ser efetuado, a polissonografia separa com clareza portadores de ronco primário de pacientes com apnéia (obstrutiva, central e mista) do sono. A causa mais freqüente da SAOS na infância é a hipertrofia adenoamigdaliana. Laringomalácia é a causa mais comum de estridor na infância, porém sua fisiopatologia permanece desconhecida. Entre as teorias mais aceitas estão a imaturidade do arcabouço cartilaginoso da ...

  6. Terrestrial planet formation in low-mass disks: dependence with initial conditions

    CERN Document Server

    Ronco, María Paula; Guilera, Octavio Miguel

    2014-01-01

    In general, most of the studies of terrestrial-type planet formation typically use ad hoc initial conditions. In this work we improved the initial conditions described in Ronco & de El\\'ia (2014) starting with a semi-analytical model wich simulates the evolution of the protoplanetary disk during the gas phase. The results of the semi-analytical model are then used as initial conditions for the N-body simulations. We show that the planetary systems considered are not sensitive to the particular initial distribution of embryos and planetesimals and thus, the results are globally similar to those found in the previous work.

  7. The External Mind

    DEFF Research Database (Denmark)

    The External Mind: an Introduction by Riccardo Fusaroli, Claudio Paolucci pp. 3-31 The sign of the Hand: Symbolic Practices and the Extended Mind by Massimiliano Cappuccio, Michael Wheeler pp. 33-55 The Overextended Mind by Shaun Gallagher pp. 57-68 The "External Mind": Semiotics, Pragmatism......, Extended Mind and Distributed Cognition by Claudio Paolucci pp. 69-96 The Social Horizon of Embodied Language and Material Symbols by Riccardo Fusaroli pp. 97-123 Semiotics and Theories of Situated/Distributed Action and Cognition: a Dialogue and Many Intersections by Tommaso Granelli pp. 125-167 Building...... Action in Public Environments with Diverse Semiotic Resources by Charles Goodwin pp. 169-182 How Marking in Dance Constitutes Thinking with the Body by David Kirsh pp. 183-214 Ambiguous Coordination: Collaboration in Informal Science Education Research by Ivan Rosero, Robert Lecusay, Michael Cole pp. 215-240...

  8. Botánica médica de los indígenas Cuna de Arquía, Chocó

    Directory of Open Access Journals (Sweden)

    Giraldo Tafur Clara

    1995-11-01

    Full Text Available A medical-botanical study in the indigenous Cuna community of Arquia (Choco with the collaboration of the Inatuledi (botanical doctor Claudio Izquierdo is presented. Different aspects about health, illness and the healing process are discussed. 146 plants are relerenced including indian language and translation, a brief description of uses and applications and the taxonomical name of 53 plants.Se presenta un estudio de botánica médica realizado en la comunidad indígena Cuna de Arquía, Chocó, con la colaboración del lnatuledi (médico-botánico Claudio Izquierdo. Se discuten diferentes aspectos sobre salud y enfermedad y la terapéutica curativa. Se referencian 146 plantas con el uso, nombre en lengua y español, parte a usar y la preparación, de las cuales 53 se identificaron taxonómicamente.

  9. 资讯快递

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    <正>Bellefontaine维美源素入驻北京新光天地7月18日,源自瑞士的护肤品Bellefontaine维美源素在北京新光天地盛大开幕,瑞士驻华大使参赞Claudio Mazzucchelli,驻中国瑞士旅游局局长Simon Bosshart,Bellefontaine瑞士总经理Mr.Peter Yip,新光天地总经理

  10. Romance e realidade na ficção brasileira contemporânea

    Directory of Open Access Journals (Sweden)

    Juliana Santini

    2012-01-01

    Full Text Available This work is a reflection on the representation of real in the novel Inferno provisório, by Luiz Ruffato, considering proposals by Claudio Magris on modern form of novel and its possible transformations in last decades. The aim is questioning the way by which aesthetic project of this novel embodies a deep point of view of real, creating an ethic and critical principle of analysis on contemporary society.

  11. Stemmer i italiensk litteratur

    DEFF Research Database (Denmark)

    omdrejningspunkt kommer danske og udenlandske forskere vidt omkring i den italienske litteratur: stemmen i ordbøgerne, stemmen hos Petrarca og i humanisternes breve, stemmens apostrofer igennem tiden, italienske stemmer hos Montaigne og humor hos Pirandello, Pirandellos stemme hos Svend Åge Madsen og Conrads...... stemme hos Calvino, litterære telefonstemmer, ny italiensk krimi, kvindestemmer før og nu, intertekstualitet hos Claudio Magris, og Magris' eget bidrag om europæiske identiteter....

  12. Highlights and Conclusions of the Chalonge 13th Paris Cosmology Colloquium

    OpenAIRE

    2010-01-01

    The 13th Chalonge Paris Cosmology Colloquium was held at the historic Perrault building of Observatoire de Paris on 23-25 July 2009. The Colloquium was held in the spirit of the Chalonge School, putting together real cosmological and astrophysical data and hard theory predictive approach in the framework of the Standard Model of the Universe. Peter Biermann, James Bullock, Claudio Destri, Hector de Vega, Massimo Giovannini, Sasha Kashlinsky, Eiichiro Komatsu, Anthony Lasenby and Norma G. Sanc...

  13. IEEE Particle Accelerator Conference on Accelerator Science and Technology Held in San Francisco, California on 6-9 May 1991. Volume 5

    Science.gov (United States)

    1991-05-01

    W. Jones, and M. J. Jakobson ...... 893 User control of the proton beam injection trajectories into the AGS booster - T. D’Ottavio, A. Kponou, A...Baird, Heinz-Dieter Nuhn , Roman Tai’chyn, Herman lWinick, Alan S. Fisher, Juan C. Gallardo, and Claudio Pellegrini...LIVERMORE CA 945W50 9700 S CASS AVENUE USA ARGONNE IL 60439 USA ROMAN J. NAWROCKY BROOKHAVEN NATL LAB WILLIAM E. JR. NEXSEN BLDG. 725B LLNL VALERIJ

  14. IEEE Particle Accelerator Conference on Accelerator Science and Technology Held in San Francisco, California on 6-9 May 1991. Volume 2

    Science.gov (United States)

    1991-05-01

    A. Browman, K. W. Jones, and M. J. Jakobson ....... 893 User control of the proton beam injection trajectories into the AGS booster - T. D’Ottavio, A... Roman Tatchyn, Herman IWinick, Alan S. Fisher, Juan C. Gallardo, and Claudio Pellegrini ....................................................... 2748...National Laboratory Los Alamos, NM 87545 M. J. Jakobson University of Montana Missoula, MT 59812 Abstract The results of the upgrade to the 750-keV H

  15. A simplified stock-flow consistent post-Keynesian growth model

    OpenAIRE

    dos Santos, Claudio H.; Zezza, Gennaro

    2005-01-01

    A Simplified Stock-Flow Consistent Post-Keynesian Growth Model Claudio H. Dos Santos* and Gennaro Zezza** Abstract: Despite being arguably the most rigorous form of structuralist/post-Keynesian macroeconomics, stock-flow consistent models are quite often complex and difficult to deal with. This paper presents a model that, despite retaining the methodological advantages of the stock-flow consistent method, is intuitive enough to be taught at an undergraduate level. Moreover, the model can eas...

  16. Research Laboratory of Electronics Progress Report Number 134

    Science.gov (United States)

    1991-12-31

    collaboration with the Dutch group headed by between two subband levels, and the other is the Profesor Horst Rogalla, which is the leading confinement of...m - ... ... ....... .. ...... . Profesor SYIVAI T. Cayer 132 ftLE Progrees Report Number 134 Chapter 3. Chemical Reaction Dynamics at Surfaces Chapter...Herbelot Janet L. Pan Claudio L. Cesar Lori K. Herold Gregory E. Penn Hwa-Ping Chang Bruce N. Ingle Brian M. Perreault Michael S. Chapman Steven H. Isabella

  17. Gravitational Lens: Deep Space Probe Design

    Science.gov (United States)

    2012-03-01

    List of Abbreviations Abbreviation Page FSM Focal Space Mission . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 CMB Cosmic Microwave...concert with the sun’s gravitational lens to image nearby solar systems and/or other pertinent astronomical objects, e.g. the Cosmic Microwave Background...CMB) radiation. 1.2 Thesis Objective In Deep Space Flight and Communications Claudio Maccone uses the mass, radius , mean density, and Schwarzschild

  18. The role of health technology assessment bodies in shaping drug development

    OpenAIRE

    Ciani O; Jommi C

    2014-01-01

    Oriana Ciani,1,3 Claudio Jommi1,2 1Centre for Research on Health and Social Care Management (CERGAS), Bocconi University, Milan, Italy; 2Department of Pharmaceutical Sciences, Università del Piemonte Orientale, Novara, Italy; 3University of Exeter Medical School, Exeter, UK Abstract: The use of health technology assessment (HTA) to inform policy-making is established in most developed countries. Compared to licensing agencies, HTA agencies have different interests and, t...

  19. Visualization of High-Order Finite Element Methods

    Science.gov (United States)

    2013-03-27

    Peters , Valerio Pascucci, Robert M. Kirby and Claudio T. Silva, "Topology Verification for Isosurface Extraction", IEEE Transactions on Visualization...Visualization of High-Order Methods Professor Robert M. Kirby , Mr. Robert Haimes University of Utah Office of Sponsored Programs University of Utah Salt Lake...ORGANIZATION REPORT NUMBER 19a. NAME OF RESPONSIBLE PERSON 19b. TELEPHONE NUMBER Robert Kirby 801-585-3421 3. DATES COVERED (From - To) 26-Sep-2008

  20. Bisphosphonate therapy and osteonecrosis of the jaw complicated with a temporal abscess in an elderly woman with rheumatoid arthritis: a case report

    OpenAIRE

    Manzon L; Ettorre E; Viscogliosi G; Ippoliti S; Filiaci F; Ungari C; Fratto G; Agrillo A.

    2014-01-01

    Licia Manzon,1 Evaristo Ettorre,1 Giovanni Viscogliosi,1 Stefano Ippoliti,1 Fabio Filiaci,2 Claudio Ungari,2 Giovanni Fratto,1 Alessandro Agrillo2 1Department of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences, 2Department of Odontology and Maxillofacial Surgery, “Sapienza” University, Rome, Italy Abstract: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is an adverse drug reaction described as the progressive destruction and deat...

  1. Cláudio Santoro , Doutor Honoris Causa da Universidade de Brasília

    OpenAIRE

    Tacuchian,Ricardo

    2007-01-01

    No contexto do XVI Congresso da ANPPOM realizado em 2006 sob os auspícios do Programa de Pós-graduação Música em Contexto, Ricardo Tacuchian, enquanto membro da Academia Brasileira de Música e relator da atribuição de Doutor Honoris Causa post-mortem, relata as contribuições de Claudio Santoro no cenário da criação musical no Brasil.

  2. Conformity cannot be identified based on population-level signatures

    OpenAIRE

    Alberto Acerbi; van Leeuwen, Edwin J. C.; Haun, Daniel B. M.; Claudio Tennie

    2016-01-01

    The Netherlands Organisation for Scientific Research (NWO VIDI-grant 016.144312) supports the research of Alberto Acerbi. Claudio Tennie would like to thank the Economic and Social Research Council for financial support (ES/K008625/1). Conformist transmission, defined as a disproportionate likelihood to copy the majority, is considered a potent mechanism underlying the emergence and stabilization of cultural diversity. However, ambiguity within and across disciplines remains as to how to i...

  3. Profile of evolocumab and its potential in the treatment of hyperlipidemia

    OpenAIRE

    Cicero AF; Colletti A; Borghi C

    2015-01-01

    Arrigo FG Cicero, Alessandro Colletti, Claudio Borghi Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy Abstract: Despite the proven efficacy of statins, they often fail to achieve low-density lipoprotein (LDL) cholesterol goals, especially in high-risk patients. Moreover, a large number of subjects cannot tolerate statins or full doses of these drugs, in particular patients with familial hypercholesterolemia. Thus, there is a need for additional effective LDL ...

  4. Graafikatriennaali peapreemia läks Lätti / Kadri Karro

    Index Scriptorium Estoniae

    Karro, Kadri

    2011-01-01

    Kumu Kunstimuuseumis avatud 15. Tallinna Graafikatriennaali "Armastuse, mitte raha pärast" Grand Prix saanud Edmunds Jansonsi (Läti) animeeritud dokumentaalfilmist "Väikese linnukese päevik" (2007). Kolm võrdset preemiat pälvinud Antonio Claudio Carvalho (Brasiilia), õde Mary Corita (Corita Kent, 1918-1986, USA) ja Alina Rudnitskaja (Venemaa) töödest. Eripreemiate saajad. Oliver Laas sai ERKF Olev Soansi mälestusfondi stipendiumi

  5. punktum. März 2010

    OpenAIRE

    2010-01-01

    Bänziger, Hans Ulrich: 2010; Dr. Turmes, Luc: Bindung und Empathie. Von wechselseitigem Aufnehmen und spiegelndem Zurückgeben; Dr. Brisch, Karl Heinz: Bindungstheorie. Die Eltern-Kind-Symbiose; Prof. Dr. Gruen, Arno: Evolution. Liebe als entscheidender Entwicklungsfaktor; Dr. Waiblinger, Eva: Altruismus bei Tieren. Das Mitgefühl der Bonobos; Garstick, Egon: Elternschaftstherapie. Psychoanalytisch orientierte Psychotherapie im öffentlichen Bereich; Moro, Claudio: Selektiver M...

  6. Maude Object-Oriented Action Tool

    OpenAIRE

    Maidl, André Murbach; Carvilhe, Cláudio,; Musicante, Martin A.

    2013-01-01

    MAIDL, André Murbach; CARVILHE, Claudio; MUSICANTE, Martin A. Maude Object-Oriented Action Tool. Electronic Notes in Theoretical Computer Science. [S.l:s.n], 2008. Object-Oriented Action Semantics (OOAS) incorporates object-oriented concepts to the Action Semantics formalism. Its main goal is to obtain more readable and reusable semantics specifications. Moreover, it supports syntax-independent specifications, due to the way classes are written. Maude Object-Oriented Action Tool (MOOAT)...

  7. Graafikatriennaali peapreemia läks Lätti / Kadri Karro

    Index Scriptorium Estoniae

    Karro, Kadri

    2011-01-01

    Kumu Kunstimuuseumis avatud 15. Tallinna Graafikatriennaali "Armastuse, mitte raha pärast" Grand Prix saanud Edmunds Jansonsi (Läti) animeeritud dokumentaalfilmist "Väikese linnukese päevik" (2007). Kolm võrdset preemiat pälvinud Antonio Claudio Carvalho (Brasiilia), õde Mary Corita (Corita Kent, 1918-1986, USA) ja Alina Rudnitskaja (Venemaa) töödest. Eripreemiate saajad. Oliver Laas sai ERKF Olev Soansi mälestusfondi stipendiumi

  8. Minutes of the Explosives Safety Seminar (25). Volume 4. Held in Anaheim, California on 18-20 Aug 1992

    Science.gov (United States)

    1992-08-01

    MARTIN MARIETTA ASTRONAUTICS CAPTAIN BARATTA GARY HAWTHORNE ARMY AMMUNITION PLANT MR. BARBERO LUIS CLAUDIO COELLO, 124 MR. BARNETTE JERRY MARINE CORPS...NEW MEXICO INSTITUTE OF MINING MR. TEO KIAN CDC CONSTRUCTION & DEVELOPMENT PTE LTD 640 MR. THOMAS JOSEPH HAWTHORNE ARMY AMMUNITION PLANT MR. THOMPSON...WILLIS RICHARD NORTHORP CORPORATION MR. WILSON NATHANIEL ARMAMENT RESEARCH, DEVELOPMENT AND MR. WINDSOR MARVIN NAVAL AIR WARFARE CENTER MR. WINGATE MARK

  9. Journal of the School of Naval Warfare (Revista da Escola de Guerra Naval)

    Science.gov (United States)

    2008-06-01

    APPROACHES - Captain (Ret) Claudio Rogeriod de Andrade Flor BOOK REVIEW HISTORIA DAS GUERRAS - Captain (Ret) Joaquim Arine Bacelar Rego 14. SUBJECT...reflected in the democratic voting system, i.e., each state is entitle to one vote. Obviously, these two cultural legacies arc inherently controversial...Japan joining the Council. A group of states - called "United for Consensus"- consisting of Pakistan, Argentina, Canada, Italy and Mexico support

  10. Counterinsurgency in Brazil: Lessons of the Fighting from 1968 to 1974

    Science.gov (United States)

    2010-01-01

    1964-1967): The organisms of spying and repression),” Quoted in Vestígios do Passado. Ampuh, RS: Associacao Nacional de Historia, 2008. http...http://www.estadao.com.br/ nacional /not_nac102644,0.htm (accessed January 09, 2010). 57 Lima, Claudio de...Castro. “O Brasil na Operação Condor (Brazil in Condor Operation). Aventuras na Historia,” Abril online, http://historia.abril.com.br/ politica /brasil

  11. Music in Galileo's Time

    Science.gov (United States)

    Petrobelli, P.

    2011-06-01

    Claudio Monteverdi appears as the key personality of the music in Galileo's time. His revolution in format and function of the musical language-from an essentially edonistic creation of purely sonorous images to a musical language consciously "expressive" of the content of the words on which it is based-is similar in character to the influential innovations in scientific thinking operated by Galileo.

  12. Recepció de la música de Georg Friedrich Händel a la Barcelona del segle XIX

    OpenAIRE

    Bonastre, Francesc

    2013-01-01

    La música de Händel sonà a Barcelona, més enllà de l’època en què va ser creada, a la recerca de l’interès cultural i artístic dels auditoris de mitjan segle XIX. L’aventura de la música händeliana a la Ciutat Comtal s’inicià el 12 de març de 1867, amb uns fragments de Rinaldo, i es va cloure a l’adveniment del segle XX, amb un repertori semblant, dirigit per Matthieu Crickboom. Les 30 obres escoltades, 20 de les quals eren vocals i 10 instrumentals, que es programaren en el transcurs de 40 a...

  13. Frode alla legge o frode della legge?

    Directory of Open Access Journals (Sweden)

    Salvatore Berlingò

    2011-03-01

    Full Text Available Il saggio riproduce con qualche variante il contenuto della voce “Fraude de ley” - che apparirà, in traduzione spagnola, nel Diccionario General de Derecho Canónico, dell’Instituto Martìn Azpilcueta - ed è destinato agli Studi in onore di Rinaldo Bertolino.SOMMARIO: 1 - “Fraus legis” e “fictio iuris” – 2. La frode della legge e la simulazione – 3. Il mendacio e la compromissione delle regole fondamentali dell’ordinamento – 4. La repressione o prevenzione di collusioni o altre frodi processuali – 5. Le  illegittimità amministrative causate da “malae fraudes” e la “bona fraus” coonestata dalla suppletio Ecclesiae.

  14. Prevalência de sintomas de distúrbios respiratórios do sono em escolares brasileiros The prevalence of symptoms of sleep-disordered breathing in Brazilian schoolchildren

    Directory of Open Access Journals (Sweden)

    Carine Petry

    2008-04-01

    Full Text Available OBJETIVO: Verificar a prevalência de sintomas de distúrbios respiratórios do sono em crianças de baixo nível socioeconômico no Sul do Brasil. MÉTODOS: Foi realizado um estudo transversal em Uruguaiana (RS, utilizando questionário específico sobre sintomas de distúrbios respiratórios do sono, respondido pelos pais, em uma amostra de escolares de 9 a 14 anos participantes do International Study of Asthma and Allergies in Childhood (ISAAC. RESULTADOS: Foram respondidos 998 questionários de um total de 1.011 escolares elegíveis. Relato de ronco habitual ocorreu em 27,6% das crianças, apnéia em 0,8%, respiração oral diurna em 15,5% e sonolência diurna excessiva em 7,8%. Crianças com sonolência diurna excessiva apresentaram maior risco de ronco habitual (OR = 2,7; IC95% 1,4-5,4, apnéia (OR = 9,9; IC95% 1,2-51, respiração oral (OR = 13,1; IC95% 6,2-27,4 e problemas de aprendizado (OR = 9,9; IC95% 1,9-51,0. Rinite, fumo materno e testes cutâneos alérgicos estiveram significativamente associados a ronco habitual e respiração oral diurna. CONCLUSÕES: A prevalência de sintomas de distúrbios respiratórios do sono é elevada em crianças de 9 a 14 anos na cidade de Uruguaiana. A prevalência de ronco habitual foi quase duas vezes maior que a descrita nessa faixa etária em outras populações. Crianças com sonolência diurna excessiva parecem ter quase 10 vezes mais risco de problemas de aprendizado.OBJECTIVE: To identify the prevalence of symptoms of sleep-disordered breathing among children of low socioeconomic status in the South of Brazil. METHODS: This was a cross-sectional study, carried out in the city of Uruguaiana, RS, in which specific questionnaire about the symptoms of sleep-disordered breathing was completed by the parents of a sample of schoolchildren aged 9 to 14 years, enrolled on the International Study of Asthma and Allergies in Childhood (ISAAC. RESULTS: From the total of 1,011 eligible schoolchildren, 998

  15. Portuguese-language version of the Epworth sleepiness scale: validation for use in Brazil Validação da escala de sonolência de Epworth em português para uso no Brasil

    Directory of Open Access Journals (Sweden)

    Alessandra Naimaier Bertolazi

    2009-09-01

    Full Text Available OBJECTIVE: The aim of this study was to develop a Portuguese-language version of the Epworth sleepiness scale (ESS for use in Brazil. METHODS: The steps involved in creating the ESS in Brazilian Portuguese (ESS-BR were as follows: translation; back-translation; comparison (by a committee between the translation and the back-translation; and testing in bilingual individuals. The ESS-BR was applied to a group of patients who were submitted to overnight polysomnography in order to identify obstructive sleep apnea-hypopnea syndrome (OSAHS, insomnia and primary snoring. A control group was composed of subjects with a history of normal sleep habits, without reported snoring. RESULTS: A total of 114 patients and 21 controls were included. The 8-item scores of the ESS-BR had an overall reliability coefficient of 0.83. The study group was composed of 59 patients with OSAHS, 34 patients with primary snoring and 21 patients with insomnia. One-way ANOVA demonstrated significant differences in ESS-BR scores among the four diagnostic groups (p 0.05. The ESS-BR scores were significantly higher for OSAHS patients and for primary snorers than for controls (p OBJETIVO: Desenvolver uma versão da escala de sonolência de Epworth (ESE para o português para uso no Brasil. MÉTODOS: A versão no português do Brasil (ESE-BR foi desenvolvida de acordo com as seguintes etapas: tradução; retrotradução; comparação entre a tradução e a retrotradução (por um comitê; e aplicação em indivíduos bilíngues. A ESE-BR foi aplicada a um grupo de pacientes submetidos à polissonografia de noite inteira para identificar síndrome da apneia-hipopneia obstrutiva do sono (SAHOS, insônia e ronco primário. Um grupo controle foi composto de indivíduos com história de hábitos normais de sono, sem ronco aparente. RESULTADOS: Um total de 114 pacientes e 21 controles foram incluídos. Os 8 itens do ESE-BR tiveram um coeficiente de confiabilidade total de 0,83. O grupo em

  16. Alterações faciais anatômicas e funcionais em escolares do município de Vitória, ES

    OpenAIRE

    Fiorott, Bruna Santos

    2012-01-01

    Introdução: O padrão de respiração bucal em crianças pode gerar repercussões negativas de impacto físico, psicológico e social. A relação da respiração bucal com os distúrbios respiratórios obstrutivo do sono (DROS) é proveniente de condições clínicas que variam em gravidade crescente desde o ronco primário, a síndrome da resistência da via aérea superior até a síndrome da apneia obstrutiva do sono. A principal causa da respiração bucal e dos DROS está associada ao estreitamento da via aérea ...

  17. Bellefontaine维美源素 北京新光天地闪亮登场

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    2009年7月18日,源自瑞士皇家殿堂级护肤品-Bellefontaine维美源素在北京新光天地盛大开幕,出席剪裁的矗亮有瑞士驻华大使参赞Claudio Mezzucchelli、驻中国瑞士旅游局局长Simon Bosshert、Bellefontaine瑞士总经理Mr Peter Yip、新光天地总经理甘添信、新光天地营业部部长朱元龙以及彩星赵雅芝等。

  18. La muerte como discurso retórico en algunos textos religiosos novohispanos

    OpenAIRE

    Rubial García, Antonio

    2012-01-01

    El estudio de la muerte como discurso retórico en algunos textos novohispanos diseña un escenario más para la investigación para mostrar cómo los autores religiosos novohispanos percibieron retóricamente la muerte en distintos tipos de narración. El tema se ha estudiado desde la antropología e investigadores como Claudio Lomnitz han encontrado contradicciones entre la visión cristiana y la imposición de una nueva concepción del estado a partir de la conquista.

  19. Network innovation through OpenFlow and SDN principles and design

    CERN Document Server

    Hu, Fei

    2014-01-01

    FUNDAMENTALSSDN /OpenFlow: Concepts and Applications; Ashley Gerrity and Fei HuAn OpenFlow Network Design Cycle; Pedro A. Aranda Gutiřrez and Diego R. LopezDESIGNIP Source Address Validation Solution with OpenFlow Extension and OpenRouter; Jun BiLanguage and Programming in SDN /OpenFlow; Muhammad Farooq and Fei HuControl and Management Software for SDNs; Natalia Castro Fernandes and Luiz Claudio Schara MagalhêsController Architecture and Performance in Software-Defined Networks; Ting Zhang and Fei HuMobile Applications on Global Clouds Using OpenFlow and Software-Defined Networking; Subharth

  20. NX15 science workshop

    CERN Multimedia

    2015-01-01

    Science. For some of us, it's daunting or maybe even terrifying. How to tell a good science story? That's the question we will explore together in this workshop. Conceived and produced by journalist and Scientific News producer Claudio Rosmino of Euronews, and presented by Euronews' Jeremy Wilks, the workshop will look at actual case studies (from Euronews and beyond) where science news proved exciting, inspiring and accessible to audiences around the world. These might include the Rosetta mission and CERN's work on Science for Peace. Together, we'll share ideas and knowledge around how science journalism and science news can increase its visibility in the media and maybe save the planet...!

  1. Reconstrucción Infográfica del Castellum de Tamuda (Tetuán, Marruecos

    Directory of Open Access Journals (Sweden)

    Javier Bermejo Meléndez

    2012-11-01

    Full Text Available The last researches developed in the lot of Tamuda's Roman castellum (Tetuan, Morocco, specially centred on the doors of the military installation, have emphasized different phases or constructive episodes in the life of the same one. This way in this work they present diverse restitutions infographics corresponding to the phases documented in the enclosure, centred of a specific way in the doors of access, offering an image of the evolution of the above mentioned military installation throughout almost four centuries, from the moments of the foundation in epoch of Claudio up to the beginnings of Vst. c. A.D.

  2. The size and shape of Dante's Purgatorio

    Science.gov (United States)

    Magnaghi-Delfino, Paola; Norando, Tullia

    2015-07-01

    Where is Mount Purgatory? How high is it? How large is the island upon which it was situated? In the previous century Rodolfo Benini and Ideale Capasso developed a series of hypothesis and calculations to find answers to these questions. Each used data derived from mathematics, astronomy, history of science and cartography, but they completely disagreed on the location and on the overall size and shape of the island. In this paper we review the main points of these two scholars, then we rework the calculations and estimates, according with a new astronomical hypothesis presented by Giulio Magli and Claudio Facciolo.

  3. Análisis de los flujos de tránsito en una calle peatonal

    OpenAIRE

    Lobos Collantes, Fernando

    2015-01-01

    Resumen: La calle Santiago es la calle más céntrica y una de las más comerciales de Valladolid. En este TFG se analiza el comportamiento del flujo de peatones en la calle Santiago a su paso por el cruce con la calle Claudio Moyano mediante técnicas estadísticas avanzadas basadas en datos funcionales como clustering, Análisis de Componentes Principales (ACP) o Análisis de la Varianza (ANOVA). También se estudiará la efectividad del semáforo inteligente ubicado en el cruce en la reducción del t...

  4. [Gout and its manifestations, description and treatment in ancient times].

    Science.gov (United States)

    Alušík, Tomáš; Alušík, Štefan

    2015-01-01

    Gout is a very old disease, which exists for thousands of years. The first descriptions interpreted as the symptoms of gout can be found already in the Egyptian medical papyri dating to the 3rd mill. BC. In the Ancient world, many physicians dealt with the causes, diagnostics and the treatments of gout, such as Hippocrates of Cos, Diocles of Carystus or Claudios Galenos. A personified gout (as the goddess Podagra) is also to be found in the Ancient mythology and culture. Several human remnants of the people suffering from gout are preserved from the Antiquity as well.

  5. Buenos Aires 1977. Crónica de una fuga.

    Directory of Open Access Journals (Sweden)

    Moira Cristiá

    2007-11-01

    Full Text Available La tragedia de numerosas familias argentinas y la guerra silenciosa que vivió una sociedad palpitante de violencia y plena de sueños que se escurrían entre sus dedos, se hace palpable en una experiencia particular, a la manera de un estudio de microhistoria. El argumento del film, inspirado en un acontecimiento verídico, es la adaptación al cine del libro autobiográfico de Claudio Tamburrini “El pase libre. La fuga de la mansión Seré”. El protagonista es un estudiante y arquero de fútbol que...

  6. Historia de la Cátedra de Terapeútica, Materia Médica y Arte de Recetar de la Facultad de Medicina de la Universidad de Valladolid: Periodo 1857-1905r

    OpenAIRE

    Velasco Sendra, Alfonso

    2012-01-01

    La Facultad de Medicina de la Universidad de Valladolid fue recuperada en 1857 gracias a las gestiones de Don Claudio Moyano Ministro de Fomento. Durante este periodo la cátedra fue desempeñada por Don Cristóbal Dámaso García, Don Eugenio Alau Comas, Don Agustín Morte Gómez, Don Victoriano Díez Martín, Don Silvestre Cantalapiedra Hernández y Don Raimundo García Quintero. Para elaborar este trabajo se han revisado los expedientes y documentos de cada uno de los profesores proced...

  7. TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport

    OpenAIRE

    Schmidts, M.; Hou, Y.; Cortés, CR; Mans, DA; HUBER, C; Boldt, K.; Patel, M.; Van Reeuwijk, J; Plaza, JM; Van Beersum, SEC; Yap, ZM; Letteboer, SJF; Taylor, SP; Herridge, W.; Johnson, CA

    2015-01-01

    ARTICLE Received 1 Oct 2014 | Accepted 31 Mar 2015 | Published 5 June 2015 TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport Miriam Schmidts1,2,3,4,*, Yuqing Hou5,*, Claudio R. Corte´s6, Dorus A. Mans2,3, Celine Huber7, Karsten Boldt8, Mitali Patel1, Jeroen van Reeuwijk2,3, Jean-Marc Plaza9, Sylvia E.C. van Beersum2,3, Zhi Min Yap1, Stef J.F. Letteboer2,3, S Paige Taylor10, Warren Herridge11, Colin A. Johns...

  8. Empoderar: nuevo concepto de liderazgo para el administrador educativo

    OpenAIRE

    Luis Enrique González Salazar

    2001-01-01

    En este artículo se realiza un análisis de las dosdirectrices enviadas por el Dr. Claudio Gutierrez cuandofue Ministro de Educación, en las que se empoderaba alas direcciones regionales de educación y se ponía en prác-tica el principio de subsidiaridad, para establecer unanueva manera de relacionar las direcciones regionalescon las oficinas centrales del Ministerio y éstas con las Ins-tituciones Educativas. Se enfatiza en el potencial de esteconcepto de liderazgo con el objeto de analizar el ...

  9. Fronteira, fusão, filme: um toque

    Directory of Open Access Journals (Sweden)

    Tunico Amancio

    2010-12-01

    Full Text Available Considered the first co-production between MERCOSUR countries, "The touch of the Oboe", a film by Claudio MacDowell, suffers from some sort of vagueness that shows off the difficulties of a complete commercial and cultural movie exchange between Brazil's neighbor countries. Even bolstered with powerful traditions, the productive associative project of this cinematic realization emblematizes an economical, symbolical and historical imbalance which still prevails among the countries of the Southern Common Market. The text notes some of these tensions, marked by the relationship between cinema and literature.

  10. ‘‘I think that the small peptides are the best for healthy ageing…’’, an interview with Vladimir Khavinson

    DEFF Research Database (Denmark)

    Rattan, Suresh

    2013-01-01

    Since its inception in 2000, Biogerontology has published interviews with some of the most renowned and intellectually influential biogerontologists, including Len Hayflick, Robin Holliday, Denham Harman,VincentCristofalo, Claudio Franceschi, Leslie Robert, Ken Kitani, Geroge Martin, Zhores...... Medvedev and John Maynard Smith. These interviews have explored the minds of these scientists in all aspects of their lives combining the private and the professional. Together, this series is a remarkable document providing an insight into the history of ideas in modern biogerontology. Here we present...

  11. Edificio de oficinas en Roma

    Directory of Open Access Journals (Sweden)

    Decker, Emilio

    1962-06-01

    Full Text Available El edificio, construido en colaboración por los arquitectos e ingenieros Emilio y Claudio Decker, Giancarlo Nale y Domenico Virgili, está edificado sobre un solar de unos 3.300 m2, con la fachada principal a la calle Lungotevere Arnaldo da Brescia, entre las Vías Mancini y Scialoja, y paralelo a la arteria de mayor tráfico. En su planteamiento se han previsto las más óptimas posibilidades de estacionamiento de automóviles, factor de suma importancia para el mejor servicio de las oficinas.

  12. Acercamientos a la ciencia ficción

    Directory of Open Access Journals (Sweden)

    Diego Vicente Rodríguez Hillón

    2015-01-01

    Full Text Available El presente artículo es un capítulo de la tesis en proceso de la Maestría en Literatura de la Universidad Pedagógica y Tecnológica de Colombia (UPTC, titulada Ciencia ficción colombiana y Modernidad: una lectura de tres obras de la primera mitad del siglo XX . El texto busca en un inicio ofrecer una definición del género como una fantasía plausible para posteriormente estudiar sus características y desarrollo a través de algunas propuestas de Claudio Guillén.

  13. De regreso a Oktubre

    OpenAIRE

    Solari, Carlos Alberto; Beilinson, Eduardo Alberto; Ideal,, E.; Villelisa; Tranquilo Enano; Don Lunfardo y el Señor Otario; López Camelo, Fernanda; Negusa Negast; Crema del Cielo; Mostruo!; Sr. Tomate; Encías Sangrantes; Heguiabere, Hernán

    2007-01-01

    Una producción de FM 107.5 Radio Universidad de La Plata. Grabado, mezclado y masterizado por Alfredo Calvelo en Estudios Hollywoodvvv. Concepto e ilustración de tapa: Juan Soto. Diseño gráfico: Kubilai Medina. Agradecimientos a Rocambole, al Chivo, a Efraín, Gustavo y Patricio de Ultrapop, a Flavio Mamini de Grafikar, Martín Boneto, Gloria Guerrero, Pablo Strozza, Eddie Babenco, Francisco Lagomarsino, Mariel Zabiuk, Alejandro Lingentti, Tom Lupo, Nicolás Miguelez, Claudio Kleima...

  14. "The Anatomy of the Bond Market Turbulence of 1994"

    OpenAIRE

    Claudio E.V. Borio; McCauley, Robert N.

    1996-01-01

    According to Claudio E. V. Borio and Robert N. McCauley, "the bond market sell-off of 1994 has begun to show up on lists of market events against which risk management systems are judged." Examples of other such events are the 1987 stock market crash and the 1995 Kobe earthquake. However, there has been little analysis of the cause of the 1994 decline. Borio and McCauley fill the void by examining a number of factors that might explain the rise in volatility during that year. The authors inve...

  15. Unraveling mulitple translatorship through an e-mail correspondence

    DEFF Research Database (Denmark)

    2017-01-01

    The aim of this study is to shed light on questions of “multiple translatorship” and particularly on translation collaboration processes. The empirical material consists of more than three hundred e-mails exchanged between two co-translators who translated Claudio Magris’s novel Alla cieca (2005......) into Danish. The theoretical framework presents a double perspective through which the e-mail correspondence is studied: on the one hand, as an ethnographic “thick description” (focusing on translation as an event), with the aim of uncovering who the agents involved are, how they interact, and what...

  16. Ocorrência da síndrome da apneia obstrutiva do sono (SAOS em crianças respiradoras orais Obstructive sleep apnea syndrome (OSAS in mouth breathing children

    Directory of Open Access Journals (Sweden)

    Suemy Cioffi Izu

    2010-10-01

    Full Text Available É bem estabelecido que a respiração oral em crianças está relacionada à hipertrofia adenoamigdaliana, que é a principal causa de apneia do sono nesta população. Apesar da importância deste tema, há poucos estudos que comprovam a relação entre SAOS e respiração oral. OBJETIVO: Determinar a prevalência de distúrbios respiratórios do sono em crianças respiradoras orais e sua correlação com achados otorrinolaringológicos. MATERIAL E MÉTODO: Foram avaliados retrospectivamente 248 prontuários de crianças respiradoras orais do serviço de Otorrinolaringologia Pediátrica de uma grande instituição entre 2000 e 2006, analisando os achados otorrinolaringológicos, polissonografia, nasofibroscopia e/ou radiografia em perfil do Cavum. O principal dado polissonográfico utilizado foi o índice de apneia (IA. Classificou-se como ronco primário aqueles com IA1. Desenho Científico: Coorte retrospectivo. RESULTADOS: Dos 248 pacientes incluídos, 144 (58% apresentavam ronco primário e 104 (42% apresentavam SAOS. Os achados otorrinolaringológicos mais frequentes foram Hipertrofia adenoamigdaliana (n=152; 61,2%, Hipertrofia de tonsila palatina (n=17; 6,8% Hipertrofia da tonsila faríngea (n=37; 14,9%, Rinite Alérgica (n=155; 62,5% e Otite Secretora (36; 14,5%. CONCLUSÕES: Ronco Primário e SAOS são frequentes em crianças respiradoras orais. A afecção otorrinolaringológica mais encontrada em crianças com SAOS é a hipertrofia adenoamigdaliana acompanhada ou não de rinite alérgica.It is well known that mouth breathing is associated with adenotonsillar hypertrophy - which is the main cause of obstructive sleep apnea among children. Despite the importance of this matter, there are only a handful of studies showing the relationship between OSAS and mouth breathing. AIM: to determine the prevalence of obstructive sleep disorders in mouth breathing children and study its correlation with otorhinolaryngological findings. STUDY

  17. Sintomas da síndrome de apnéia-hipopnéia obstrutiva do sono em crianças Symptoms of obstructive sleep apnea-hypopnea syndrome in children

    Directory of Open Access Journals (Sweden)

    Paloma Baiardi Gregório

    2008-06-01

    Full Text Available OBJETIVOS: Investigar os sintomas mais freqüentes encontrados em crianças com diagnóstico polissonográfico de síndrome da apnéia-hipopnéia obstrutiva do sono (SAHOS. MÉTODOS: Foram avaliadas 38 crianças consecutivamente encaminhadas ao laboratório do sono com suspeita de SAHOS no período de junho de 2003 a dezembro de 2004. Os pacientes foram submetidos a um questionário pré-sono e a polissonografia. RESULTADOS: A idade média foi de 7,8 ± 4 anos (variação, 2-15 anos, sendo 50% das crianças do sexo masculino. Não apnéicos corresponderam a 7,9% dos pesquisados, distúrbio leve obstrutivo do sono ocorreu em 42,1%, moderado em 28,9% e severo em 22,1%. Observou-se maior freqüência de casos severos de apnéia entre crianças menores de seis anos (idade pré-escolar. Dentre as crianças com SAHOS, os sintomas mais citados foram ronco e obstrução nasal, presentes em 74,3 e 72,7% das crianças, respectivamente. Sonolência excessiva e bruxismo ocorreram em, respectivamente, 29,4 e 34,3% dos casos e doença do refluxo em apenas 3,1%. Agitação das pernas e dificuldade para iniciar o sono foram encontradas em, respectivamente, 65 e 33% dos avaliados. Todas as crianças que apresentaram SAHOS de grau severo tinham queixa de ronco e bruxismo. CONCLUSÕES: Nossos resultados mostraram que os sintomas mais freqüentes em crianças e adolescentes com SAHOS são ronco e obstrução nasal. Além disso, quadros mais graves da SAHOS estão associados à menor faixa etária.OBJECTIVE: To investigate the symptoms most frequently found in children with a polysomnographic diagnosis of obstructive sleep apnea-hypopnea syndrome (OSAHS. METHODS: We evaluated 38 children consecutively referred to the sleep laboratory with suspicion of OSAHS between June of 2003 and December of 2004. The patients were submitted to a pre-sleep questionnaire and to polysomnography. RESULTS: The mean age was 7.8 ± 4 years (range, 2-15 years, and 50% of the children

  18. PRÁTICAS MUSICAIS, REDES DE SOCIABILIDADE E CULTURA INTELECTUAL NA CORRESPONDÊNCIA ENTRE FRANCISCO CURT LANGE E CLÁUDIO SANTORO -1940/1946. (Dossiê: Música, Linguagem e Sociedade.

    Directory of Open Access Journals (Sweden)

    Loque Arcanjo Junior

    2016-09-01

    Full Text Available Resumo: São diversos os personagens do nacionalismo musical brasileiro que trocaram cartas com o musicólogo alemão radicado no Uruguai, Francisco Curt Lange, (1903-1997. A proposta da primeira etapa da pesquisa da qual este artigo é resultado se concentrou no estudo das cartas inéditas trocadas entre Curt Lange e o mais renomado modernista brasileiro, Mário de Andrade. O ineditismo destas cartas, ainda não utilizadas como objeto de pesquisa até aquele momento, demonstrou a relevância desta investigação que ainda está em andamento. Apesar do foco da primeira etapa se concentrar nas cartas trocadas entre Lange e Mário de Andrade, durante a pesquisa, diversos outros atores tais como, Villa-Lobos, Camargo Guarnieri, Guerra-Peixe, Koellreuter e Claudio Santoro apareceram dentro de uma rede de sociabilidades tecida pelo projeto musicológico de Curt Lange: o Americanismo Musical. A ampliação do estudo desta rede se concentra agora nas cartas trocadas entre Curt Lange e Cláudio Santoro (1919-1989. O presente artigo trata daquelas cartas trocadas entre os anos nos de 1942 e 1946 e os diálogos estas com esta rede mais ampla. Este é um momento decisivo para a vida musical de Claudio Santoro, pois este procurava se estabelecer como compositor em meio aos nacionalismos que emergiam num contexto político e cultural bastante significativo para a história da música no Brasil. Palavras-chaves: Prática missivista, nacionalismos, governo VargasAbstract: There are several characters from the Brazilian musical nationalism exchanged letters with the German musicologist living in Uruguay, Francisco Curt Lange (1903-1997. The proposal of the first stage of the research on which this article is a result focused on the study of unpublished letters exchanged between Curt Lange and the most renowned Brazilian modernist Mário de Andrade. The novelty of these letters, not yet used as a research object, until that time, demonstrated the relevance of

  19. Relação entre hipertensão arterial sistêmica e síndrome da apnéia obstrutiva do sono

    Directory of Open Access Journals (Sweden)

    Cavallari Fransérgio E.M.

    2002-01-01

    Full Text Available Introdução: hipertensão arterial sistêmica (HAS e a Síndrome da Apnéia Obstrutiva do Sono (SAOS são doenças prevalentes na população mundial e, embora despertem interesse na comunidade médica, não têm fisiopatologia e mecanismos pelo qual produzem suas complicações completamente elucidados. A SAOS está cada vez mais relacionada a patologias cardiovasculares, principalmente à hipertensão, que é prevalente em pacientes com SAOS. Objetivo: Em nosso estudo, objetivamos avaliar as alterações encontradas na presença de HAS em pacientes portadores de SAOS. Forma de estudo: Clínico prospectivo randomizado. Material e método: Estudamos uma população de pacientes do Ambulatório de Ronco e Apnéia do HC FMRP - USP, de fevereiro de 1999 a fevereiro de 2002, em um total de 42, sendo 30 (71,42% pacientes homens e 12 (28,58% mulheres, com idades de 21 a 77 anos (média de 45,3, dp = 9,372706, todos com diagnóstico de SAOS confirmado pela polissonografia, divididos em dois grupos de 21 pacientes com SAOS (controle e 21 com SAOS e HAS. Avaliamos as escalas de Epworth, Ronco e Sonolência nos dois grupos, além do uso da polissonografia para estudo objetivo. Resultado: Não encontramos diferença estatística entre os grupos na comparação dos resultados das escalas, mesmo tendo o grupo de hipertensos médias maiores. Ao avaliarmos objetivamente os pacientes com a polissonografia, levando em conta o IDR, há estatística significante (p=0,0326, com os hipertensos apresentando médias maiores. Vendo a proporção nos grupos, há predomínio de pacientes com apnéia moderada e grave entre os hipertensos, e leve entre os do controle. Conclusão: Concluindo, a concomitância entre HAS e SAOS representa fator agravante no grau da apnéia.

  20. Editorial Note

    Science.gov (United States)

    2016-02-01

    As from January 2016, Dr. Andrew Barry and Dr. Andrea Rinaldo have retired as Editors of Advances in Water Resources. Dr Barry has been a long serving Editor for 14 years, beginning this role on January 1, 2002. During this time he has served the science community with dedication, commitment, and diligence while bringing to the journal a strong vision and a wealth of knowledge that has tremendously improved the visibility and impact of Advances in Water Resources. Throughout this period he has also broadened the scope of the journal by adapting to the new emerging needs of the field through proactively seeking and promoting numerous special issues, which have now become a hallmark of the journal. The importance of obtaining high quality reviews and timeliness in decision-making, have always been a priority under Dr Barry's Editorship. It is clear that Advances in Water Resources and the community which it serves, has benefited enormously under Andrew's tenure and we will miss his energy, enthusiasm and passion for hydrologic science.

  1. PERFIL DAS CRIANÇAS SUBMETIDAS À AMIGDALECTOMIA E/OU ADENOIDECTOMIA EM UM HOSPITAL GERAL DE TAUBATÉ-SP

    Directory of Open Access Journals (Sweden)

    Tais Maria Candido Marcondes

    2017-01-01

    Full Text Available As amígdalas são conhecidas como tonsilas palatinas estão localizadas na orofaringe e as adenóides como tonsilas faríngeas, localizadas atrás das fossas nasais. Objetivo: Identificar o perfil clínico e cirúrgico das crianças submetidas a amigdalectomia e/ou adenoidectomia em um hospital de Taubaté - SP. Método: Pesquisa retrospectiva e quantitativa. Resultados: Foram pesquisados 361 prontuários. A faixa etária, foi de 4 a 7 anos em 32,32%, sexo masculino em 50,42%; a indicação cirúrgica foi hipertrofia adenoamigdaliana em 85,04%; o ronco prevaleceu em 32,03% e a inflamação da garganta, em 45,54%,  cirurgia de adenoamigdalectomia em 85,04%, tempo de cirurgia foi de 0-20 minutos em 60,94%, tempo de internação de 16h-20h em 37,67%. Conclusão: o perfil das crianças foi de 4 a 7 anos de idade; masculino; com hipertrofia adenoamigdaliana; cirurgia adenoamigdalectomia; período de internação de 16h a 20h e com ausência de complicações.

  2. História clínica e exame físico em SAOS: clinical history and physical examination Obstructive sleep apnea syndrome

    Directory of Open Access Journals (Sweden)

    Gleison Marinho Guimarães

    2010-06-01

    Full Text Available Embora SAOS seja uma patologia comum, é frequentemente subdiagnosticada. Seus sinais e sintomas são, na sua maioria, subjetivos e, portanto, deve haver suspeição diagnóstica quando existir roncos, sonolência diurna, cansaço, desânimo e alteração de humor. Escalas e tabelas com boa sensibilidade, que incluem os sintomas clínicos mais relevantes e dados do exame físico, podem indicar o diagnóstico de SAOS. A confirmação diagnóstica é realizada através de polissonografia, considerada o método padrão ouro.Although obstructive sleep apnea syndrome is a common disease, it often goes undiagnosed. The signs and symptoms of the syndrome are mostly subjective. Therefore, snoring, daytime sleepiness, fatigue, dejection and mood changes should raise the suspicion of obstructive sleep apnea syndrome. Scales and tables that have good sensitivity and include the most relevant clinical symptoms and physical examination results can suggest a diagnosis of obstructive sleep apnea syndrome. The diagnosis is confirmed by polysomnography, which is considered the gold standard method.

  3. New Hopf Structures on Binary Trees (Extended Abstract)

    CERN Document Server

    Forcey, Stefan; Sottile, Frank

    2009-01-01

    The multiplihedra {M_n} form a family of polytopes originating in the study of higher categories and homotopy theory. While the multiplihedra may be unfamiliar to the algebraic combinatorics community, it is nestled between two families of polytopes that certainly are not: the permutahedra {S_n} and associahedra {Y_n}. The maps between these families reveal several new Hopf structures on tree-like objects nestled between the Malvenuto-Reutenauer (MR) Hopf algebra of permutations and the Loday-Ronco (LR) Hopf algebra of planar binary trees. We begin their study here, constructing a module over MR and a Hopf module over LR from the multiplihedra. Rich structural information about this module is uncovered via a change of basis--using M\\"obius inversion in posets built on the 1-skeleta of the {M_n}. Our analysis uses the notion of an interval retract, which should have independent interest in poset combinatorics. It also reveals new families of polytopes, and even a new factorization of a known projection from th...

  4. Epidemiologia dos distúrbios respiratórios do sono Epidemiology of sleep-disordered breathing

    Directory of Open Access Journals (Sweden)

    Carlos Alberto de Assis Viegas

    2010-06-01

    Full Text Available Os principais distúrbios respiratórios do sono, ronco e SAOS, são muito prevalentes na população geral, embora se acredite que a maioria dos casos continue não diagnosticada. Devemos estar atentos para os principais fatores de risco que favorecem o aparecimento desses distúrbios, como gênero masculino, obesidade, envelhecimento e características crânio-faciais. Da mesma forma, a presença de hipertensão arterial sistêmica, enfermidades cardiovasculares e metabólicas deve nos alertar para a possibilidade da concomitância de SAOS.The principal types of sleep-disordered breathing-snoring and obstructive sleep apnea syndrome-are highly prevalent in the general population, although it is believed that the majority of cases continue to go undiagnosed. We should be aware of the principal risk factors that favor the onset of these disorders, such as male gender, obesity, aging and craniofacial features. Similarly, systemic arterial hypertension, cardiovascular diseases and metabolic disorders should alert us to the possibility of obstructive sleep apnea syndrome.

  5. Le Mouvement Socialavril –juin 1999, n° 187Périphéries et centres/ Enseignants et syndicalisme

    OpenAIRE

    Soufi, Fouad

    2013-01-01

    Le local et le national, le centre et la périphérie analysés à partir de la question sicilienne (1861-1876) par Jean-Louis Briquet et de l’organisation de l’espace social dans le village de Tepoztàn au Mexique par Claudio Lomnitz, avec une présentation essentielle de Gilles Pécout. La seconde partie de la revue est consacrée au syndicalisme enseignant : la Fédération Unitaire de l’Enseignement entre 1919 et 1929 (Loïc Le Bras) d’une part et d’autre part, la syndicalisation des enseignants du...

  6. Financiamiento para las Micro y Pequeñas Empresas. Algunas Líneas de Acción

    Directory of Open Access Journals (Sweden)

    Janina León Castillo

    1998-06-01

    Full Text Available El presente artículo se basa en un documento más extenso: “The Promotion of Small and MicroEnterprises: A Source Book” preparado para el Banco Interamericano de Desarrollo (BID y la Fundación para el Desarrollo Sostenible (FUNDES, como Relatorio de la Conferencia Internacional “Crédito para la pequeña y la microempresa”, realizada en Washington D.C. en Junio, 1994. Los autores agradecen los comentarios de Douglas Graham y Claudio González Vega (The Ohio State University, Carlos Cuevas (Banco Mundial, Mark Flaming (BID, y Markus Reichmuth (FUNDES. Por supuesto, todo error u omisión es de nuestra entera responsabilidad. Muchas de las ideas planteadas en este artículo emergieron a inicios de la presente década, y su difusión está aún en proceso.

  7. CERN’s policy in the field of knowledge and technology transfer goes global

    CERN Multimedia

    CERN Bulletin

    On 2 November, the Knowledge & Technology Transfer (KTT) Group presented to the Directorate three proposals that aim to enhance KTT activities. One important aspect of the proposals is the direct involvement of all members of CERN, who are strongly encouraged to communicate any ideas for additional applications of their work. KTT is a high-priority activity area because of its potential to demonstrate the role of CERN as a source of innovation, delivering tangible benefits to society. In particular, through its know-how and its leadership, CERN is today generating innovations applicable in domains such as medical sciences, energy and the environment, as well as many others. “The measures endorsed by the Directorate on 2 November include a comprehensive policy for managing the intellectual property related to CERN technologies”, explains Claudio Parrinello, head of the KTT Group in the DG Department. “This includes a proposal to redistribute part of the income generated by ...

  8. Empoderar: nuevo concepto de liderazgo para el administrador educativo

    Directory of Open Access Journals (Sweden)

    Luis Enrique González Salazar

    2001-01-01

    Full Text Available En este artículo se realiza un análisis de las dosdirectrices enviadas por el Dr. Claudio Gutierrez cuandofue Ministro de Educación, en las que se “empoderaba” alas direcciones regionales de educación y se ponía en prác-tica el principio de subsidiaridad, para establecer unanueva manera de relacionar las direcciones regionalescon las oficinas centrales del Ministerio y éstas con las Ins-tituciones Educativas. Se enfatiza en el potencial de esteconcepto de liderazgo con el objeto de analizar el estadoactual del proceso de “empoderamiento” en la DirecciónRegional de Alajuela, visto este como un continuo entre laautonomía y el control en los estilos de liderazgo practica-do por los directores cinco del circuito 01

  9. Science.gov (United States)

    In life and work, Claudio Bunster prefers extreme challenges. Bunster, a physicist who contemplates brain-warping theories of space and time, returned to his native Chile from the United States precisely when most intellectuals would have stayed clear - during the middle of the Pinochet dictatorship. Shut out of the universities by the military government, he broke the conventional mold by founding a research institute that he then moved from Santiago, the capital, to Valdivia in southern Chile, against the flow of minds and money. He led the presidential science advisory committee during the administration of Eduardo Frei, and served on the Dialogue Board of Human Rights to reconcile Chilean military and civil society. For his achievements, Bunster was elected to the National Academy of Sciences in 2005. In his Inaugural Article, which appeared in the July 24, 2007 issue of PNAS [1], he showed that after a black hole swallows a magnetic monopole, the space-time singularity starts rotating.

  10. Reinforced concrete in Catalonia (1898-1929: four companies and their relationship with architecture

    Directory of Open Access Journals (Sweden)

    R. Graus

    2017-06-01

    Full Text Available Between 1898 and 1929 various business initiatives that introduced reinforced concrete in its architecture developed in Catalonia. This article studies the following four companies: Anónima Claudio Duran - Construcciones Monier, Marial Hermanos - Sociedad Colectiva, Construcciones y Pavimentos, S. A. and Material y Obras, S. A. Only thorough knowledge of the production complexities that studies these companies, their technicians and works in all its complexity will allow us to assess how reinforced concrete transformed the construction sector, with new companies of a different productive scale. However, the depressed economic cycle of 1929-1952 weighed down any initiative and artificially lengthened what was left of traditional “Catalan construction”.

  11. Su 1910. L'emancipazione della dissonanza: Per una retorica della gioventù

    Directory of Open Access Journals (Sweden)

    Niccolò Scaffai

    2014-05-01

    Full Text Available Pubblichiamo qui un saggio inedito di Thomas Harrison, Rhetoric of Youth, or Bridges to Nowhere, nel contesto di un numero che proprio alla retorica e ai suoi poteri è dedicato. Nell’articolo, Harrison riprende alcuni concetti e figure del suo volume 1910: The Emancipation of Dissonance, appena tradotto in Italia, dove è stato recensito fra gli altri da Claudio Magris (sul «Corriere della Sera» e da Valerio Magrelli (su «la Repubblica». Se pure con ritardo – in America il volume è apparso nel 1996 – il pubblico italiano ha oggi a disposizione un saggio intorno al quale si è raccolto il consenso di intellettuali e critici di area e formazione diverse.

  12. Technical Directors of Fineland with Experts of Codelco on the Road%与智利国营铜业围炉论道——山东方圆公司技术负责人与智利Codelco专家对话侧记

    Institute of Scientific and Technical Information of China (English)

    聂刚

    2011-01-01

    今年8月底,智利国营制业公司( Codelco)组织的专家考察闭一行,再次来到东营.行程早就定了,然而因为种种原因, 一拖再拖,终于两个月后成行.Claudio·Queirolo,Aquiles Veas,Patricio·Peralta三位实践型技术专家,从地球的另一端赶来了.他们此行目的很明确,就是为了与方圆的同行们坐下来,好好聊一下彼此在多年生产实践中感悟出来、积累下来的“铜理铜道”,相互学习,取长补短.

  13. "I think that the small peptides are the best for healthy ageing...", an interview with Vladimir Khavinson. Interview by Suresh I. S. Rattan.

    Science.gov (United States)

    Khavinson, Vladimir

    2013-02-01

    Since its inception in 2000, Biogerontology has published interviews with some of the most renowned and intellectually influential biogerontologists, including Len Hayflick, Robin Holliday, Denham Harman, Vincent Cristofalo, Claudio Franceschi, Leslie Robert, Ken Kitani, Geroge Martin, Zhores Medvedev and John Maynard Smith. These interviews have explored the minds of these scientists in all aspects of their lives combining the private and the professional. Together, this series is a remarkable document providing an insight into the history of ideas in modern biogerontology. Here we present Vladimir Khavinson talking about his life and work in Russia during and after the Soviet times, his ideas on stress and health, his discoveries of the healthy ageing promoting small peptides, and other anti-ageing interventions.

  14. Nuclear isoscaling and fair sampling

    Science.gov (United States)

    Lopez, Jorge

    2008-10-01

    The isoscaling phenomenon was first observed in nuclear multifragmentation experiments and has become a hot topic as it could provide a probe of the nuclear equation of state to understand nuclear matter at extreme condition of isospin such as in neutron stars. The present work studies isoscaling using 1) classical molecular dynamics simulations, 2) percolation and 3) probabilistic arguments, and determines that isoscaling is a general phenomenon that can exist independent of the nuclear reaction, and it is expected to occur in disassemblying systems with no more than fair sampling. In collaboration with Alan Davila, University of Texas at Austin; Claudio Dorso, Universidad de Buenos Aires; Carlos Hernandez, Universidad de Colima; Christian Escudero, University of Texas at El Paso; and Jorge Muñoz, CalTech.

  15. Margherita Maria Di Nino, I Fiori campestri di Posidippo. Ricerche sulla lingua e lo stile di Posidippo di Pella

    Directory of Open Access Journals (Sweden)

    Yannick Durbec

    2012-07-01

    Full Text Available L’édition du papyrus P. Mil. Vogl. VIII 309 par Guido Bastianini et Claudio Gallazzi fut pour les spécialistes de l’Antiquité un événement majeur. Les centaines de publications qui s’ensuivirent ont ouvert de multiples pistes de réflexion, préparant la voie pour des travaux de synthèse. Le présent ouvrage de Margherita Maria Di Nino, qui est le fruit de la réélaboration de sa thèse soutenue à l’université de Bologne, est plus que cela. En effet, ce volume o...

  16. 听乐

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    <正>钢琴贵族实至名归Claudio Arrau美国Uhiversal与钢琴名牌Stein- way & Sons出版5件双CD.5位都是Steinway artists(即接受该厂赞助的著名钢琴家)。智利出生.受德国学派教育,老师是李斯特学生Martin Krause的Arrau的一款,很值得推荐。他弹的贝多芬与李斯特,布局雄奇,音响灿烂,扣人心弦。有他在1952年录制的《英雄变奏曲》,是首次在CD上发行(原DG录

  17. La Política Municipal de los Flavios en Hispània. El Municipium Irnitanum

    OpenAIRE

    Muñiz Coello, Joaquín

    1984-01-01

    La Hispània del 68 d. C. sólo haba sufrido superficialmente los efectos del caos en que los últimos años de Nerón habían sumido al gobierno de Roma. Los excesos cometidos en la ciudad por el último de los Julio-Claudios, en materia de gasto y despilfarro público, apenas fueron significativos en Hispània, más por la dejación1 que este emperador hizo de sus funciones de gobernante de un imperio, que por deseo expreso de preservar de la ruina a sus subditos de Occidente. En definitiva, ¡por una ...

  18. “Gaucho primero, después hombre, después negro”. Identidad y relaciones en la pieza teatral El gaucho negro

    Directory of Open Access Journals (Sweden)

    Matías Emiliano Casas

    2014-11-01

    Full Text Available The semantic of the word "gaucho" has been attributed with many meanings in different fields of study and artistic productions. The word's new signification and etymology and the gaucho participation in the economic development of Argentina, among other questions, have been the subject of dispute since the first studies about Independence until today. The play The Gaucho Black of Claudio Martínez Payva, premiered in 1927 at the National Theatre in Buenos Aires, revealed a series of problems, such as: the link with foreign settlers, the construction of identity through the gaucho figure and the relationship with black people. This study provides new tools to analyze the Rioplatense society and culture in the early Twentieth Century.

  19. Slow Travel: in viaggio con l’asino

    Directory of Open Access Journals (Sweden)

    Silvia Mantovani

    2015-11-01

    Full Text Available In viaggio con l’asino (A journey with a donkey is a travel book written by Andrea Bocconi e Claudio Visentin, which describes the adventures of hu- mans and animals along an ancient path in the heart of Abruzzo, as well as recalling the legendary travels with a donkey in the Cévennes don by Robert Louis Stevenson, providing useful informa- tions - practical and philosophical suggestions to manage donkeys – but above all promoting re- marks about travelling, territories, identities and landscapes. This is an interesting lesson, wich in- vites to reflect on different readings: behind a simple travel book, that fascinates, amuses and in- trigues, there are many important ideas that emerge in the watermark. They concern some of the most pressing issues about landscape. 

  20. Ultrasound surveillance in endoluminal laser treatment for varicose veins

    Directory of Open Access Journals (Sweden)

    Varetto G

    2013-10-01

    Full Text Available Gianfranco Varetto, Paolo Garneri, Claudio Castagno, Valentina Molinaro, Simone Quaglino, Matteo Ripepi, Emilio Benintende, Lorenzo Gibello, Stefano Zan, Luigi Contessa, Ugo Bertoldo, Pietro Rispoli Vascular Surgery, Department of Surgical Sciences, University of Turin, Turin, Italy Abstract: Venous ultrasonography is an indispensable tool in minimally invasive surgery for the treatment of varicose veins. However, the criteria for defining preoperative imaging parameters, outcome monitoring, and follow up are not well characterized. In this retrospective study, we reviewed the ultrasound periprocedural parameters and the outcomes in 274 patients (280 limbs after endoluminal laser treatment, at early (<30 days and late (1–60 months follow up. Treatment failure was defined as complete recanalization of the saphenous trunk, thigh perforator vein insufficiency, and recanalization of the proximal saphenous trunk. Judicious patient selection correlated with favorable outcome at the follow-up ultrasound examination. Keywords: follow-up, chronic venous disease, intravenous, obliteration

  1. At the Foot of the Volcano - Organ and Counterpoint in Naples around 1600

    Directory of Open Access Journals (Sweden)

    Ring, Johannes

    2006-12-01

    Full Text Available In 1575, Rocco Rodio published a “Fantasia” on the hymnus “Ave maris stella” in Naples in his Libro di ricercate. In the context of the progressive contributions to music for keyboard instruments of his contemporaries Antonio Valente (1575, Claudio Merulo and Andrea Gabrieli, Rodio’s setting of cantus firmus seems nothing short of anachronistic. But Rodio’s intention lies in the implementation of counterpoint. For him, the art of counterpoint was the decisive basis of the composer’s craft. Rodio’s intention is illuminated by the circumstances of his creative activity –the academies in Naples, always eager to dispute,– and by certain events in Rome and Palermo that culminated in the appearance of the Spaniard named Sebastián Raval. The original context regarding the history of music for Rodio’s “Ave maris stella” is in the liturgical organ music by Antonio de Cabezón, Manuel Rodriguez Coelho und Jean Titelouze und perhaps by António Carreira.

    1575 veröffentlichte Rocco Rodio in Neapel in seinem Libro di ricercate eine Fantasia über den Kirchenhymnus “Ave maris stella”. Im Kontext der progressiven Beiträge zur Tastenmusik seiner italienischen Zeitgenossen Antonio Valente (1575, Claudio Merulo und Andrea Gabrieli erscheint Rodios Cantus firmus-Satz geradezu anachronistisch. Doch Rodios Intention ist die des Kontrapunktikers. Für ihn war die kontrapunktische Kunst die entscheidende Basis des kompositorischen Handwerkes. Rodios Intention wird beleuchtet durch das Umfeld seines Wirkens –den diskussionsfreudigen Akademien in Neapel– und durch Ereignisse in Rom und Palermo, die im Auftritt des Spaniers Sebastián Raval gipfeln. Ihren eigentlichen musikhistorischen Kontext findet Rodios „Ave maris stella“ in der (liturgischen Orgelmusik von Antonio de Cabezón, Manuel Rodriguez Coelho und Jean Titelouze und vielleicht sogar von António Carreira.

  2. IMPARARE L’ITALIANO L2 CON LE CANZONI. UN CONTRIBUTO DIDATTICO

    Directory of Open Access Journals (Sweden)

    Elisabetta Mauroni

    2011-07-01

    Full Text Available Il presente contributo si inserisce nel filone degli studi che hanno messo in evidenza la potenziale ricchezza della canzone come strumento di facilitazione dell’apprendimento della L2, e come mezzo per l’approccio al testo letterario per studenti di italiano L1, additandone il carattere di attività particolarmente efficace e ‘consonante’ con una prospettiva umanistico-affettiva, comunicativa, nonché socio-costruttivista. In queste pagine sono presentate alcune attività didattiche (pensate ora per gli apprendenti di italiano L2, ora per gli studenti di italiano L1 formulate a partire da alcuni testi del cantautore Claudio Baglioni (Io sono qui, Le vie dei Colori, Bolero, Fammi andar via tratti dall’album Io sono qui, 1995, edizioni CBS. I testi qui didattizzati sono utilizzabili in diverse prospettive: grammaticale, lessicale, retorica, socio-culturale, ecc.; e per diversi livelli di competenza linguistica (L2: A1-C1; L1.     Learning italian l2 through song.  A didactic contribution   This article is part of a series of studies which focus on the potential richness of songs as tools for facilitating L2 learning, as well as being a way to approach literary texts for L1 Italian students, being a particularly effective activity from a humanistic-affective, communicative and socio-constructivist point of view.  A few didactic activities are presented (designed for L2 Italian learners, or for L1 Italian learners based on songs by Claudio Baglioni (Io sono qui, Le vie dei Colori, Bolero, Fammi andar via from the album Io sono qui, 1995, edizioni CBS.  The texts were adapted for diverse didactic uses: grammatical, lexical, rhetorical, socio-cultural, etc and for different levels of linguistic competence (L2: A1-C1, L1

  3. Is the Dissociative Experiences Scale able to identify detachment and compartmentalization symptoms? Factor structure of the Dissociative Experiences Scale in a large sample of psychiatric and nonpsychiatric subjects

    Directory of Open Access Journals (Sweden)

    Mazzotti E

    2016-06-01

    Full Text Available Eva Mazzotti,1 Benedetto Farina,2 Claudio Imperatori,2 Federica Mansutti,3,4 Elena Prunetti,3,4 Anna Maria Speranza,5 Claudio Barbaranelli1 1Department of Psychology, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy; 2Department of Human Sciences, European University of Rome, Rome, Italy; 3Associazione di Psicologia Cognitiva e Scuola di Psicoterapia Cognitiva, Rome, Italy; 4Casa di Cura Villa Margherita, Arcugagno (Vi Italy, 5Department of Dynamic and Clinical Psychology, Sapienza University, Rome, Italy Background: In this study, we explored the ability of the Dissociative Experiences Scale (DES to catch detachment and compartmentalization symptoms.Participants and methods: The DES factor structure was evaluated in 768 psychiatric patients (546 women and 222 men and in 2,403 subjects enrolled in nonpsychiatric settings (1,857 women and 546 men. All participants were administered the Italian version of DES. Twenty senior psychiatric experts in the treatment of dissociative symptoms independently assessed the DES items and categorized each of them as follows: “C” for compartmentalization, “D” for detachment, and “NC” for noncongruence with either C or D.Results: Confirmatory factor analysis supported the three-factor structure of DES in both clinical and nonclinical samples and its invariance across the two groups. Moreover, factor analyses results overlapped with those from the expert classification procedure.Conclusion: Our results showed that DES can be used as a valid instrument for clinicians to assess the frequency of different types of dissociative experiences including detachment and compartmentalization. Keywords: Dissociative Experiences Scale, confirmatory factor analysis, detachment, compartmentalization, validity

  4. Intento de una definición genérica del poema renacentista italiano a la luz de las reflexiones teóricas de Ortega y Gasset, Lúkacs y Bajtin

    Directory of Open Access Journals (Sweden)

    Irena Prosenc Šegula

    2004-12-01

    Full Text Available La definición genérica de la novela o de lo novelesco es problemática tal cual, sin reparar ya en la forma histórica de la novela a la cual queremos aplicarla. Este artículo propone una contribución a la definición genérica del poema renacentista italiano de los finales del siglo XV y del siglo XVI, a base de las reflexiones de José Ortega y Gasset, Georg Lukács y Mijail Bajtin sobre la novela. La investigación se refiere a las tres obras más importantes de la épica italiana renacentista: Orlando enamorado (Orlando innamorato de Matteo Maria Boiardo de finales del siglo XV, Orlando furioso de Ludovico Ariosto de la primera mitad del siglo XVI y Jerusalén liberada (Gerusalemme liberata de Torquato Tasso de la segunda mitad del siglo XVI. Además han sido incluidos algunos poemas descritos en general como menores: Guirón el Cortés (Gyrone il Cortese de Luigi Alamanni, Amadís (Ama- digi de Bernardo Tasso, Reinaldo (Rinaldo de Torquato Tasso – todos de la midad del siglo XVI – y Jerusalén conquistada (Gerusalemme conquistata de Torquato Tasso de finales del siglo XVI. La base de todas estas obras es sin duda el poema caballeresco, ya que sus autores constantemente vuelven a introducir sus motivos y fórmulas estilísticas.

  5. Religioni e ateismi: una complexio oppositorum alla base del neo-separatismo europeo

    Directory of Open Access Journals (Sweden)

    Nicola Colaianni

    2011-06-01

    Full Text Available Testo della relazione svolta al Colloquio internazionale La laicità nella costruzione dell’Europa. Dualità del potere e neutralità religiosa, svoltosi in Bari il 4-5 novembre 2010 per iniziativa della Facoltà di Giurisprudenza dell’Università di Bari “Aldo Moro”, del Centre d’études internationales sur la romanité Université de La Rochelle e dell’Unità di ricerca “Giorgio La Pira” CNR – Università di Roma “La Sapienza”. Lo scritto, che sarà pubblicato negli atti del Colloquio, è destinato agli Studi in onore di Rinaldo Bertolino.SOMMARIO: 1. Il dialogo dell’Unione europea con le organizzazioni confessionali e non – 2. Il separatismo statunitense – 3. Il neo-separatismo europeo – 4. La complexio oppositorum nell’elaborazione cattolica … - 5 … e in quella secolare – 6. Il separatismo pluralistico europeo (e americano.ABSTRACTReligions and Atheisms: a Complexio Oppositorum at hearth of the European New-SeparatismThe European Union is not interested in religious phenomenon. It’s a form of separatism between State and Church. Yet the last Treaty about the Union functioning stated an “open, transparent and regular dialogue” between the Union and the Churches and the philosophical or non-confessional organizations alike. So religions and atheisms, the exact opposites, are not only recognized but also linked as complexio oppositorum. That originates a pluralistic separatism. By means of constitutional law research this paper demonstrates that this new-separatism is new for the Europe but usual for the U.S. and therefore it contributes a long way towards a rapprochement between Europe and America from the constitutional point of wiew.

  6. Força muscular respiratória e capacidade funcional em idosas hipertensas com sonolência diurna excessiva Respiratory muscle strength and physical fitness in hypertensive elderly women with excessive daytime sleepiness

    Directory of Open Access Journals (Sweden)

    Rafaela Pedrosa

    2010-06-01

    Full Text Available O objetivo do estudo foi verificar se a sonolência diurna excessiva (SDE afeta a capacidade funcional (CF e força muscular respiratória entre idosas hipertensas. O estudo avaliou 32 idosas hipertensas, divididas em dois grupos (com SDE, n=17, 64,9±5,3 anos; e sem SDE, n=15, 65,9±5,5 anos, quanto a: força muscular respiratória, por manovacuometria; CF, pelo Questionário para avaliação de limitação das atividades e por testes de aptidão funcional; nível de atividade física, pelo questionário internacional de atividade física IPAQ; grau de SDE, pela escala de sonolência de Epworth; qualidade do sono, pelo índice de qualidade do sono de Pittsburgh; e intensidade do ronco, pela escala de ronco de Stanford. Os dois grupos, homogêneos quanto a características antropométricas e da hipertensão, foram comparados estatisticamente quanto a parâmetros de sono, pressões respiratórias máximas, nível de atividade física e CF. Foi encontrada diferença significativa na qualidade do sono (p=0,03, tendo as hipertensas com SDE qualidade de sono muito ruim; porém não foram encontradas diferenças significativas entre os grupos nas pressões inspiratória e expiratória máximas, nem quanto aos testes de CF. Conclui-se que a força dos músculos respiratórios não sofre alteração em decorrência da presença de SDE em idosas hipertensas e que essa sonolência não interfere na capacidade funcional.The purpose of the study was to inquire whether excessive daytime sleepiness (EDS affects functional capacity (FC and respiratory muscle strength in elderly hypertensive patients. Thirty-two elderly hypertensive female patients were divided into two groups (with EDS, n=17, mean age 64.9±5.3; without EDS, n=15, mean age 65.9±5.5 and were assessed as to respiratory muscle strength by spirometry; FC, by the Questionnaire on limitations in physical activities and by functional fitness tests; physical activity level, by the International

  7. Ocorrência de alterações da motricidade oral e fala em indivíduos portadores de fissuras labiopalatinas - doi:10.5020/18061230.2004.p27

    Directory of Open Access Journals (Sweden)

    Raquel Nascimento da Silva

    2012-01-01

    Full Text Available O objetivo desta pesquisa foi investigar quais alterações de fala e motricidade oral freqüentemente ocorrem em pacientes portadores de fissuras labiopalatinas, através do estudo dos prontuários de investigação fonoaudiológica, datados entre os anos de 1997 e 2002, do Núcleo de Atenção Médica Integrada / NAMI da UNIFOR. Quarenta e quatro prontuários de pacientes foram estudados, sendo 18 do sexo feminino e 26 do sexo masculino. Todos demonstraram alguma alteração relacionada à hipernasalidade, golpe de glote e/ou ronco nasal; emissão de fricativa faríngea; distorções, omissões, principalmente dos fonemas /k – g – s – z – t - d - p - b/ e substituição por traço de sonoridade. Ainda foram encontrados: escape de ar nasal; alteração de mobilidade e/ou tonicidade de lábios, língua e/ou bochechas, bem como alterações de postura de língua e compensações. O estudo revelou ainda presença de úvula bífida e fístula na região posterior do palato. Sendo assim, pôde-se observar a ocorrência de alterações fonoaudiológicas freqüentemente manifestadas nos quadros de fissura labiopalatina, e necessitando, portanto, da presença do fonoaudiólogo inserido na equipe interdisciplinar envolvida.

  8. Wolfgang Geiger (17 July 1921 - 3 July 2000

    Directory of Open Access Journals (Sweden)

    Renata Boucher-Rodoni

    2000-08-01

    Full Text Available Wolfgang Geiger died on the 3rd July 2000, at the age of 79. He was born on July 17th 1921 in Biel; his mother died at his birth. His childhood was spent with his father, a well-known artist, partly in Ligerz, on Lake Biel, and partly in Porto Ronco in Ticino, on Lago Maggiore. After high school in Biel, he began his University studies, first at the Swiss Federal Institute of Technology in Zürich, then in Basel, where he studied under Professor A. Portmann. During his PhD a grant from the Janggen-Pöhn foundation enabled him to work for some months at the Institut des Pêches maritimes du Maroc, in Casablanca, with Dr. J .Furnestin. In 1953 he completed his PhD on teleost fish brain. His career as a biologist began in Bern at the Eidgenossische Inspektion für Fortwesen, Jagd und Fischerei. In 1962 he was appointed head assistant (chef des travaux at the University of Geneva, in the comparative anatomy and physiology laboratory (Dr H. J. Huggel, where he discovered the joys and the limitations of teaching. He was highly regarded as a lecturer and taught in a relaxed atmosphere of mutual respect and trust, much appreciated by his students. Professor Geiger was also the main organiser of field trips to Sète, on the French Mediterranean coast, where he was in his element living on the water. He went out on the trawlers with the students and introduced them enthusiastically to the marvels of sea fauna. He was happy during those field trips and had the knack of communicating his happiness to the students.

  9. Medicinal clays improve the endurance of loaded inspiratory muscles in COPD: a randomized clinical trial of nonpharmacological treatment

    Directory of Open Access Journals (Sweden)

    Baldi S

    2015-10-01

    Full Text Available Simonetta Baldi,1 Gian Domenico Pinna,2 Claudio Bruschi,1 Fabrizio Caldara,3 Roberto Maestri,2 Elena Dacosto,1 Antonella Rezzani,1 Ermanno Popovich,1 Ezio Bellinzona,1 Paola Crotti,1 Silvia Montemartini,1 Claudio Fracchia1 1Department of Pneumology, 2Department of Biomedical Engineering, Scientific Institute of Montescano, Salvatore Maugeri Foundation, Istituto Di Ricovero e Cura a Carattere Scientifico, Montescano (Pavia, 3Center of Thermal Studies Pietro d’Abano, AbanoTerme, Padua, Italy Background: Inspiratory resistive breathing (IRB challenges affect respiratory muscle endurance in healthy individuals, which is considered to be an interleukin 6 (IL-6–dependent mechanism. Whether nonpharmacological thermal therapies promote the endurance of loaded inspiratory muscles in chronic obstructive pulmonary disease (COPD is unclear. The objectives of this study were to compare the effects of two thermal interventions on endurance time (ET and plasma IL-6 concentration following an IRB challenge.Methods: This study was a randomized, parallel-group, unblinded clinical trial in a single-center setting. Forty-two patients (aged 42–76 years suffering from mild to severe COPD participated in this study. Both groups completed 12 sessions of the mud bath therapy (MBT (n=22 or leisure thermal activity (LTA (n=19 in a thermal spa center in Italy. Pre- and postintervention spirometry, maximum inspiratory pressure, and plasma mediators were obtained and ET and endurance oxygen expenditure (VO2Endur were measured following IRB challenge at 40% of maximum inspiratory pressure.Results: There was no difference in ΔIL-6 between the intervention groups. But, IRB challenge increased cytokine IL-6 plasma levels systematically. The effect size was small. A statistically significant treatment by IRB challenge effect existed in ET, which significantly increased in the MBT group (P=0.003. In analysis of covariance treatment by IRB challenge analysis with LnVO2

  10. Comercio mediterráneo en el castro de Montealegre (Pontevedra, Galicia. Siglo II a.C. – inicios del s. I d. C.

    Directory of Open Access Journals (Sweden)

    González-Ruibal, Alfredo

    2007-12-01

    Full Text Available The Iron Age hillfort of Montealegre, in the Atlantic coast of Galicia (NW Spain, has yielded an interesting array of Mediterranean imports during the last excavations (2003-2004. These imports span mainly from the mid-2nd c. BC to the early 1st c. AD. The late Punic and early Roman trade in the northwest of Iberia was until now scarcely known, unlike the Julio- Claudian commercial relations. The artefacts that made their way to this end of the world include late Punic (Mañá C2b, Iberian (Pellicer D and Italic (Dressel 1 amphorae, kalathoi from Catalonia, and common ware, among other things. The Julio-Claudian period is also well represented, especially by numerous amphorae (Dressel 2/4, Haltern 70, Dressel 7/11. The variety and quantity of imports from the mid-2nd c. BC onwards proves the strong integration of the Galician coast in the Mediterranean network before the Roman conquest of the area.El castro de Montealegre, en la costa de Galicia, ha proporcionado en recientes excavaciones un interesante conjunto de importaciones mediterráneas, de mediados del siglo II a.C. a inicios del siglo I d.C. principalmente. El comercio tardopúnico y romano preaugusteo en el noroeste ibérico era hasta hace poco escasamente conocido, frente a las relaciones comerciales del período julio-claudio. Los objetos que llegaron a este finis térrea incluyen ánforas tardopúnicas (Mañá C2b, ibéricas (Pellicer D e itálicas (Dressel 1, kalathoi de Cataluña y cerámica común, entre otras cosas. El período julio-claudio está asimismo bien representado por numerosas ánforas, fundamentalmente de la Bética (Dressel 2/4, Haltern 70, Dressel 7/11. La variedad y cantidad de importaciones desde mediados del siglo II a.C. en adelante demuestra la gran integración de la costa galaica en las redes mediterráneas desde antes de la conquista romana.

  11. Cost-effectiveness analysis on the use of rFSH + rLH for the treatment of anovulation in hypogonadotropic hypogonadal women

    Directory of Open Access Journals (Sweden)

    Papaleo E

    2014-06-01

    Full Text Available Enrico Papaleo,1 Carlo Alviggi,2 Giorgio Lorenzo Colombo,3,4 Claudio Pisanelli,5,6 Claudio Ripellino,7 Salvatore Longobardi,8 Pier Luigi Canonico91Centro Scienze della Natalità, Gynecological-Obstetrics Department, San Raffaele Hospital, Vita-Salute San Raffaele, Milan, Italy; 2Department of Neuroscience, Reproductive Sciences and Odontostomatology, University “Federico II” of Naples, Naples, Italy; 3Department of Drug Sciences, University of Pavia, Pavia, Italy; 4SAVE Studi Analisi Valutazioni Economiche, Milan, Italy; 5ACO San Filippo Neri, Rome, Italy; 6Società Italiana Di Farmacia Ospedaliera, Milan, Italy; 7CSD Medical Research Srl, Milan, Italy; 8Medical Department, Merck Serono SpA, Rome, Italy; 9Department of Pharmaceutical Sciences, University of Piemonte Orientale, Novara, Italy Background: Hypogonadotropic hypogonadal women are characterized by ovarian functionality deficiency, caused by low concentrations of follicle-stimulating hormone (FSH and luteinizing hormone (LH. To recover reproduction functionality, recommended therapies for ovarian induction involve injections of FSH and LH medications. Objective: Since important differences exist between recombinant and urinary gonadotropin therapies in terms of efficacy and cost, the objective of this study was to develop a cost-effectiveness model to compare recombinant FSH (rFSH + recombinant LH (rLH and highly purified human menopausal gonadotropin (HP-HMG. Methods: A Markov model was developed, considering three cycles of therapy; probability of pregnancy and miscarriage were considered, and the efficacy was evaluated in terms of pregnancy occurrence. The perspective of the model was that of the Italian Health Service, so only direct cost (drugs, specialist visits, patient examinations, and hospitalizations were included. Results: rFSH + rLH is associated with a higher total cost (€3,453.50 and higher efficacy (0.87 compared with HP-HMG (€2,719.70 and 0.50. rFSH + r

  12. El Jardín Botánico de Madrid y sus relaciones con Francia

    Directory of Open Access Journals (Sweden)

    Peset, José Luis

    1996-06-01

    Full Text Available The Botanical Garden from Madrid was created in 1755 with the purpose of studying and cultivate the medicinal plants. Its ulterior evolution is characterized for its relationship with the Garden of Plants of Paris, circumstance that retarded the application of the Linnean system in favor of the model of Tournefort. With the transfer of the Garden, in 1774, to its actual location of the Paseo del Prado, the French bond increases. The first professor, Casimiro Gómez Ortega, travels to Paris where he contacts with André Thouin, Duhamel de Monceau, and Buffon, whose botanical guidelines try to introduce at his return. But it will be at the posterior management of Claudio Boutelou, during the reign of José I, when the French presence in the Garden obtains its paramount influence. Influence and collaboration between the two institutions that continues today.

    El madrileño Jardín Botánico fue creado en 1755 con el fin de estudiar y cultivar las plantas medicinales. Su ulterior evolución se caracteriza por su relación con el parisino Jardín de Plantas, circunstancia que retrasó la aplicación del sistema linneano en favor del modelo de Tournefort. Con el traslado en 1774 del Jardín a su actual emplazamiento del Paseo del Prado, el vínculo francés aumenta. El primer catedrático Casimiro Gómez Ortega viaja a París donde contacta con André Thouin, Duhamel de Monceau y Buffon, cuyas directrices botánicas trata de implantar a su regreso. Pero será con la posterior dirección de Claudio Boutelou, durante el reinado de José I, cuando la presencia francesa en el Jardín alcanza su máxima cuota. Influencia y colaboración entre las dos instituciones que llegará hasta hoy.

  13. España y los españoles

    Directory of Open Access Journals (Sweden)

    Caba, Rubén

    2011-10-01

    Full Text Available The author here argues in favour of the historical reality that we call Spain. To recognize the Cadiz Constitution of 1812 as the origin of present Spain, he maintains, does not imply that our country had no national identity before the 19th century. And to this effect he expounds the famous controversy between Americo Castro and Claudio Sánchez-Albornoz. Before the Arab invasion there were no “españoles”, since this word of provençal origin dates back to the 11th century, as Castro points out. However, it is also true that during the Roman as well the Gothic domination, the peninsular inhabitants were known as “hispani”, as Sánchez-Albornoz sarcastically alleges. In addition, this article includes a number of quotations from Latin, Gothic and Spanish writers of the Middle Ages and the Renaissance, references which bear witness to a feeling of belonging to an old country called “Hispania” or “España”.

    El autor aporta argumentos en favor de la realidad histórica que llamamos España. Sostiene que reconocer a la Constitución de Cádiz de 1812 como origen de la España política actual no implica que nuestro país careciera de identidad nacional antes del siglo XIX. Y expone la controversia de Américo Castro y de Claudio Sánchez-Albornoz sobre la génesis histórica de España para concluir que, si bien antes de la invasión árabe no había “españoles”, vocablo provenzal del siglo XI como advierte Castro, también es cierto que durante la dominación romana y goda los peninsulares eran “hispani”, como alega con sorna Sánchez-Albornoz. Además, se recogen citas de autores latinos, godos y españoles tanto medievales como renacentistas que testimonian su sentimiento de pertenecer a un viejo país llamado Hispania o España.

  14. Kikuchi-Fujimoto disease mimicking tuberculous lymphadenitis or lymphoma on fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography

    Directory of Open Access Journals (Sweden)

    Abdul Rahim N

    2016-07-01

    Full Text Available Noraini Abdul Rahim,1 Abdul Jalil Nordin,2 Chiara Rusconi,3 Cristina Gabutti,3 Erika Ravelli,4 Claudio Rossetti5 1Diagnostic Imaging Department, Serdang Hospital, Selangor, 2Centre for Diagnostic Nuclear Imaging, University Putra Malaysia, Serdang, Malaysia; 3Department of Haematology, Ospedale Niguarda, Milan, 4Unit of Haematology, Valduce Hospital, Como, 5Department of Advance Technology (Nuclear Medicine, Ospedale Niguarda, Milan, Italy Abstract: Kikuchi-Fujimoto disease, also known as histiocytic lymphadenitis is a rare and benign disease characterized by regional cervical lymphadenopathy with fever of unknown origin, affecting mainly young women. We describe a case of a young Asian female who was initially misdiagnosed as having tuberculous lymphadenitis because of multiple lymphadenopathies with 18-fluorodeoxyglucose uptake on positron emission tomography/computed tomography. Final histologic diagnosis of Kikuchi-Fujimoto disease was made after excisional biopsy of the affected lymph node. The cervical lymphadenopathy has reduced in size and lung lesions disappeared after 2 months without specific treatment. Keywords: cervical lymphadenopathy, Kikuchi disease, PET/CT features

  15. REDISCOVERING MISES-HAYEK MONETARY AND BUSINESS CYCLE THEORY IN LIGHT OF THE CURRENT CRISIS: CREDIT EXPANSION AS A SOURCE OF ECONOMIC BOOM AND BUST

    Directory of Open Access Journals (Sweden)

    Marcin Mrowiec

    2013-10-01

    Full Text Available The article starts with a brief description of Mises’ monetary theory, with emphasis on the Misesian differentiation of two kinds of credit: commodity and circulation credit, and with the description of the impact of circulation credit expansion on the business cycle. Further on it is described how Mises’ insights constituted the kernel of Austrian Business Cycle Theory, and how the same observations on the nature of credit constituted the kernel of the Chicago Plan (though Mises’ views on the nature of credit led him to different conculsions than it led the authors of the Chicago Plan, and how this plan is being “rediscovered” now. The following sections deal with observations of one of the preeminent current macroeconomic researches, Mr. Claudio Borio, on the elasticity of credit as the source of the current crisis, and on the importance of the financial cycle in analysing the current economic crisis. The author of this text demonstrates that Austrian Business Cycle Theory gave the same answer regarding the sources of economic crises that now modern macroeconomic theory seems to be approaching, and that the postulates for successful financial cycle modeling are already included in the ABCT. Finally, some observations on the current crisis, as well as proposals of avenues of further research are proposed.

  16. Procedure for obtaining visas for Switzerland and France

    CERN Multimedia

    2006-01-01

    Signature Rights In accordance with the Status Agreements with CERN, Switzerland and France facilitate the entry of members of the Organization's personnel on to their territories. Where relevant, detailed procedures for obtaining visas apply. Within the framework of those procedures, only the following individuals are authorised to initiate the note verbale procedure as well as to sign the Official Invitation Letters and the Protocoles d'accueil. Oliver BRÜNING Philip BRYANT Lyndon EVANS John FERGUSON David JACOBS Catherine JONES Hélène HALLER-MAUGER Michelle MAZERAND Chris ONIONS Claudio PARRINELLO The French and Swiss Authorities will reject any request signed by a person who is not on this list. We would like to remind you that in accordance with the memorandum of 7 December 2000 issued by the Director of the Administration, (ref. DG/DA/00-119), 'the Organization shall not request any legitimisation document (or residence permit) or visa from the Host States for persons registered as EXTERNAL' (p...

  17. Procedure for obtaining visas for Switzerland and France - Signature Rights

    CERN Document Server

    HR Department

    2007-01-01

    In accordance with their Status Agreements with CERN, Switzerland and France facilitate the entry of members of the Organization's personnel onto their territories. Where relevant, detailed procedures for obtaining visas apply. Within the framework of these procedures, only the following individuals are authorised to initiate the note verbale procedure, as well as to sign the Official Invitation Letters and the Protocoles d'accueil. Oliver BRÜNING Philip BRYANT Lyndon EVANS John FERGUSON Hélène HALLER-MAUGER David JACOBS Catherine NEDERMAN Chris ONIONS Claudio PARRINELLO Jeanne ROSTANT The French and Swiss Authorities will reject any request signed by a person who is not on this list. We would like to remind you that, in accordance with the memorandum of 7 December 2000 issued by the Director of Administration, (ref. DG/DA/00-119), 'the Organization shall not request any legitimisation document (or residence permit) or visa from the Host States for persons registered as EXTERNAL' (people w...

  18. Procedure for obtaining visas for Switzerland and France

    CERN Multimedia

    2007-01-01

    Signature Rights In accordance with the Status Agreements with CERN, Switzerland and France facilitate the entry of members of the Organizations personnel on to their territories. Where relevant, detailed procedures for obtaining visas apply. Within the framework of those procedures, only the following individuals are authorised to initiate the note verbale procedure as well as to sign the Official Invitation Letters and the Protocoles daccueil. Oliver BRÜNING Philip BRYANT Lyndon EVANS John FERGUSON Hélène HALLER-MAUGER David JACOBS Catherine NEDERMAN Chris ONIONS Claudio PARRINELLO Jeanne ROSTANT The French and Swiss Authorities will reject any request signed by a person who is not on this list. We would like to remind you that in accordance with the memorandum of 7 December 2000 issued by the Director of the Administration, (ref. DG/DA/00-119), 'the Organization shall not request any legitimisation document (or residence permit) or visa from the Host States for persons registered as E...

  19. PROCEDURE FOR OBTAINING VISAS FOR SWITZERLAND AND FRANCE

    CERN Multimedia

    2007-01-01

    SIGNATURE RIGHTS In accordance with the Status Agreements with CERN, Switzerland and France facilitate the entry of members of the Organization’s personnel on to their territories. Where relevant, detailed procedures for obtaining visas apply. Within the framework of those procedures, only the following individuals are authorised to initiate the note verbale procedure as well as to sign the Official Invitation Letters and the Protocoles d’accueil. •\tOliver BRÜNING •\tVinod CHOHAN •\tLyndon EVANS •\tJohn FERGUSON •\tHélène HALLER-MAUGER •\tDavid JACOBS •\tPhilippe LEBRUN •\tCatherine NEDERMAN •\tChris ONIONS •\tClaudio PARRINELLO •\tJeanne ROSTANT The French and Swiss Authorities will reject any request signed by a person who is not on this list. We would like to remind you that in accordance with the memorandum of 7 December 2000 issued by the Director of the Administration, (ref. DG/DA/00-119), "the Organization shall not request any legitimisation d...

  20. Procedure for obtaining visas for Switzerland and France

    CERN Document Server

    Relations with the Host States Service

    2006-01-01

    Signature rights In accordance with their Status Agreements with CERN, Switzerland and France facilitate the entry of members of the Organization's personnel onto their territories. Where relevant, detailed procedures for obtaining visas apply. Within the framework of these procedures, only the following individuals are authorised to initiate the note verbale procedure, as well as to sign the Official Invitation Letters and the Protocoles d'accueil. Oliver BRÜNING Philip BRYANT Lyndon EVANS John FERGUSON Catherine JONES Nicolas KOULBERG Hélène HALLER-MAUGER Michelle MAZERAND Chris ONIONS Claudio PARRINELLO The French and Swiss Authorities will reject any request signed by a person who is not on this list. We would like to remind you that, in accordance with the memorandum of 7 December 2000 issued by the Director of the Administration (ref. DG/DA/00-119), 'the Organization shall not request any legitimisation document (or residence permit) or visa from the Host States for persons registered as EXTERNA...

  1. PROCEDURE FOR OBTAINING VISAS FOR SWITZERLAND AND FRANCE

    CERN Multimedia

    2007-01-01

    SIGNATURE RIGHTS In accordance with the Status Agreements with CERN, Switzerland and France facilitate the entry of members of the Organization’s personnel on to their territories. Where relevant, detailed procedures for obtaining visas apply. Within the framework of those procedures, only the following individuals are authorised to initiate the note verbale procedure as well as to sign the Official Invitation Letters and the Protocoles d’accueil. •\tOliver BRÜNING •\tPhilip BRYANT •\tLyndon EVANS •\tJohn FERGUSON •\tHélène HALLER-MAUGER •\tDavid JACOBS •\tPhilippe LEBRUN •\tCatherine NEDERMAN •\tChris ONIONS •\tClaudio PARRINELLO •\tJeanne ROSTANT The French and Swiss Authorities will reject any request signed by a person who is not on this list. We would like to remind you that in accordance with the memorandum of 7 December 2000 issued by the Director of the Administration, (ref. DG/DA/00-119), "the Organization shall not request any legitimisation document (or residence per...

  2. Staging Death, Translating Death, Rehearsing Death: A Photographer’s Apprenticeship in Dying

    Directory of Open Access Journals (Sweden)

    Daniela Fargione

    2010-10-01

    Full Text Available The preponderance of death imagery in the mass media and a recent interest of photography in the practice of death suggest the need to reevaluate our approach to death and dying, especially when violence is involved. This essay is a case study of History of Violence, Claudio Cravero's last photographic project. His collection of "portraits" reproduce apparent dead bodies, mostly attacked in their own domestic spheres, but neither the perpetrator of death (a mysterious murderer?, nor the weapon used (an omnipresent knife, should be considered as main focal points of the artist's inquiry. The undoubtful protagonist of these photographs, instead, is the light, that illuminates fear: not of death itself, rather of the obnoxious indifference to it, as the result of generalized death imagery saturation.     The staged apparent death displayed in Cravero's photographs serve both as a memento mori and as a strategy to come to terms with the idea of death. In short, it is an apprentship in dying through a domesticating translation practice. Eventually, Cravero's History of Violence offers a complex reflection on the interplay between each individual story and macrolevel social History, thus providing some hypotheses of where violence and death fit in that odd geometry of time and space that we call life.

  3. Alfabetización informacional a través de Moodle

    Directory of Open Access Journals (Sweden)

    Gabriela Fernanda Cabrera Rossi

    2015-01-01

    Full Text Available Se describe la experiencia de la Biblioteca “Dr. Claudio Williman” de la Facultad de Educación Física del Instituto Universitario de la Asociación Cristiana de Jóvenes (IUACJ, en el desarrollo de cursos que contribuyen a la mejora de la calidad formal de los trabajos académicos. Se presentan distintos tipos de cursos impartidos por Biblioteca de carácter semipresencial, los cuales generan créditos académicos y son desarrollados bajo la plataforma Moodle. Se describe el proceso de integración del IUACJ a Moodle como herramienta educativa facilitadora para el desarrollo y organización de los cursos. Se analiza la contribución del bibliotecólogo, como gestor de información, evaluando recursos para luego ponerlos a disposición de la comunidad académica de estudiantes, proporcionando acciones que contribuyan a consolidar a la Biblioteca en su rol de alfabetizador, favoreciendo la adquisición de conocimientos y habilidades de los usuarios. También se enumeraran los cursos dictados por la Biblioteca describiendo estructura, metodología aplicada y recursos didácticos.

  4. Staff Members with more than 25 years service at CERN in 2000

    CERN Multimedia

    2000-01-01

    Allegrini Roberto SL Arimatea Claudio SL Baudic Yves SPL Becquet Christian SL Bergamaschi Angelo ST Bourquin Pierre EST Brand Jean-Paul ST Bresciani Pietro EST Brocard Robert EP Cameron Willie EST Carminati Daniel PS Chasseloup De Laubat Jacques ST Chouvelon Alain TIS Cittolin Sergio EP Cochet Evelyne ST Coly Patrick LHC David Eric EP De Jonge Luit Koert SL Delattre André LHC Detraz Claude Charles EP Dreesen Peter PS Dydak Friedrich EP Favini Pierre EST Ferioli Gianfranco SL Fiebiger Heinz PS Fontbonne Andrée HR Fournel Jacques EST Fournier Gérard AS Fromm Daniel EP Gagliardi Fabrizio IT Gaidon Michèle ST Galbraith Peter LHC Gavaggio Richard LHC Genand Roger SL Gendre Francis PS Geoffroy Michel ST Geretschlager Ingrid ETT Grabit Robert EP Grill Manfred ST Heinze Wolfgang PS Hoh Roger PS Hudry Jean SL Jenny Bernard EST Koutchouk Jean-Pierre SL Laffin Michel SL Laurent Jean-Michel LHC Le Gras Marc PS Legrand Patrick LHC Lerho Jean-Marie ST Lewis Ray ETT Liptow Ulr...

  5. “History is not linear … it zigzags”: The Perception of Time in Magris' novel Blindly

    Directory of Open Access Journals (Sweden)

    Irena Prosenc Šegula

    2012-12-01

    Full Text Available In his novel Blindly Claudio Magris develops a complex perception of time. This perception is intertwined with reflections on history, identity and the status of the narrative voice. History, which “is not linear” but “zigzags” is presented as a continuously repetitive phenomenon, while temporal time is impossible to measure. The status of the autodiegetic narrator becomes highly problematic as the narrative voice assumes identities belonging to various historical periods ranging from the late 18th to the 20th centuries. The novel focuses on repressive historical periods which deform the protagonists' identities, thereby conveying an image of history as a blind and violent force. Fragmentation, one of the basic narrative techniques in the novel, concerns time sequences as well as the protagonists' identities and the narrative voice itself. As the protagonists' lives can only be narrated as fragments, there are frequent passages between different time periods. These merge into extratemporality, which is associated with eternal suffering stemming from the repetitive, oppressive nature of history. The historical events depicted in the novel are interpreted through the extratemporal dimension of the Argonaut myth.

  6. Aproximación a la enseñanza secundaria durante el Franquismo (1938-1967

    Directory of Open Access Journals (Sweden)

    Leoncio VEGA GIL

    2010-03-01

    Full Text Available RESUMEN: El trabajo que abordamos en esta monografía se centra cronológicamente en el ciclo histórico conocido como franquismo y a nivel de contenido delimitamos el estudio a la enseñanza secundaria tanto desde su dimensión formal y política, a partir de los pilares legislativos que sobre este nivel se fueron erigiendo (1938, 1953 y 1967, como desde la realidad escolar en términos cuantitativos de la geografía nacional y un estudio interno más profundo de algunas variables para el caso de su articulación en Zamora. Y, si las fuentes nos lo permiten, entraremos en las cuestiones del «tercer nivel», la mentalidad del alumno de segunda enseñanza y su relación con el modelo social y académico real de los alumnos que asisten a cursar estudios en el Instituto «Claudio Moyano» de Zamora o de los que cursan la enseñanza colegiada, tan potenciada esta última ahora por el régimen.

  7. Importance of perforating vessels in nipple-sparing mastectomy: an anatomical description

    Directory of Open Access Journals (Sweden)

    Amanti C

    2015-07-01

    Full Text Available Claudio Amanti,1 Valeria Vitale,1 Augusto Lombardi,1 Stefano Maggi,1 Laura Bersigotti,1 Gianni Lazzarin,1 Emiliano Nuccetelli,1 Camilla Romano,1 Laura Campanella,1 Lara Cristiano,2 Alessandra Bartoloni,2 Giuseppe Argento2 1Breast Surgery Unit, 2Radiology Unit, University of Roma, La Sapienza Sant'Andrea Hospital, Rome, Italy Background: Nipple-sparing mastectomy (NSM, understood as an oncologically valid procedure, is relatively new, and is an evolution of traditional mastectomy, particularly in relation to breast-conserving surgery. The anterior perforating branches are responsible for the cutaneous vascularization of the breast skin, and their preservation is a fundamental step to avoid possible postoperative necrosis. Therefore, evaluating the potential complications of cancer-related reconstructive surgical procedures such as NSM, both the distance of the tumoral lesion from the skin and the surgical incision site should be carefully considered. The preferred site of incision corresponds to the inframammary fold or possibly the periareolar area.Methods: We retrospectively reviewed 113 patients who underwent NSM from January 2005 to October 2012 to evaluate skin complications. The anatomical study was performed by magnetic resonance imaging of the breast.Results: Only one of the 113 women who had undergone a NSM procedure had total necrosis (0.9% and six patients had partial necrosis (5.8% of the nipple-areola complex. Keywords: nipple-sparing mastectomy, breast, magnetic resonance imaging, breast perforating vessels, breast anatomy

  8. The beginnings of dermatopathology and dermatologic microbiology in Spain.

    Science.gov (United States)

    del Río, E

    2014-03-01

    Crisóstomo Martínez from Valencia was a pioneering microscopist in 17th-century Europe. The first microscopic representations of skin in Spain appeared in an 18th-century work by Martín Martínez. Microbiology and histopathology progressed considerably in the late 19th century thanks to anatomists like Maestre de San Juan and surgeons like Federico Rubio Galí. The first Spanish pathologist to specialize in dermatology was Antonio Mendoza, a colleague of José Eugenio de Olavide at the Hospital San Juan de Dios in Madrid. Claudio Sala and Juan de Azúa also made significant contributions, including the description of pseudoepithelioma. Several disciples of Santiago Ramón y Cajal and Jorge FranciscoTello, such as Lorenzo Ruiz de Arcaute and Guillermo de la Rosa King, consolidated the dermatology laboratory, but the Civil War sent many into exile or deprived them of their professional status. Juan Rubió in Barcelona and Julio Rodríguez Puchol in Madrid were the immediate predecessors of today's dermatopathologists. Copyright © 2012 Elsevier España, S.L. y AEDV. All rights reserved.

  9. Bisphosphonate therapy and osteonecrosis of the jaw complicated with a temporal abscess in an elderly woman with rheumatoid arthritis: a case report

    Directory of Open Access Journals (Sweden)

    Manzon L

    2014-08-01

    Full Text Available Licia Manzon,1 Evaristo Ettorre,1 Giovanni Viscogliosi,1 Stefano Ippoliti,1 Fabio Filiaci,2 Claudio Ungari,2 Giovanni Fratto,1 Alessandro Agrillo2 1Department of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences, 2Department of Odontology and Maxillofacial Surgery, “Sapienza” University, Rome, Italy Abstract: Bisphosphonate-related osteonecrosis of the jaw (BRONJ is an adverse drug reaction described as the progressive destruction and death of bone tissue of the mandible or maxilla, in the course of bisphosphonate therapy. Orally administered bisphosphonates, widely used for the treatment of osteoporosis, are rarely associated with BRONJ. Instead, the risk greatly increases whether the patient is concomitantly taking steroid and/or immunosuppressant agents. The aims of this paper are to briefly discuss the evidence of the associations between bisphosphonate therapy and BRONJ, and the effects of co-occurring factors such as the presence of rheumatoid arthritis, dental surgery, and concomitant corticosteroid therapy. In particular, we present the case of an elderly woman with BRONJ suffering from rheumatoid arthritis, with a recent dental extraction and with a very unusual complication: a temporal abscess, who was successfully treated. Keywords: bisphosphonate-related osteonecrosis of the jaw, BRONJ, adverse reaction, steroidsA Letter to Editor has been received and published for this article

  10. Targets, attitudes, and goals of psychiatrists treating patients with schizophrenia: key outcome drivers, role of quality of life, and place of long-acting antipsychotics

    Directory of Open Access Journals (Sweden)

    de Bartolomeis A

    2016-01-01

    Full Text Available Andrea de Bartolomeis,1 Andrea Fagiolini,2 Marco Vaggi,3 Claudio Vampini4 1Section of Psychiatry and Treatment Resistant Psychosis, Department of Neuroscience, University of Naples Federico II, Naples, Italy; 2Department of Molecular and Developmental Medicine, School of Medicine, University of Siena, Siena, Italy; 3Mental Health and Drug Addiction Department, Genovese, Genoa, Italy; 4Department of Mental Health, Ospedale Civile Maggiore and ULSS 20, Verona, Italy Purpose: This survey of Italian psychiatrists was conducted to better define drivers of schizophrenia treatment choice in real-life practice, particularly for use of long-acting injectable (LAI antipsychotics.Methods: Between October 15 and December 15, 2014, 1,000 surveys were sent to psychiatrists who treat schizophrenic patients; 709 completed questionnaires were analyzed (71% response rate.Results: The two most important factors determining therapy success were efficacy (75% of responses and tolerability (45% followed by global functioning (24% and quality of life (17%. LAI antipsychotics were most often used to facilitate regular treatment monitoring (49%, and 41% of psychiatrists thought that patients with low adherence who had failed oral therapy were well-suited for LAI antipsychotics. Only 4% of respondents saw LAI antipsychotics as appropriate for patients without other therapeutic options.Conclusion: Although efficacy and tolerability were the most common factors used to evaluate treatment success in schizophrenia, psychiatrists also consider QoL and global functioning to be important. Keywords: quality of life, long-acting injectable antipsychotics, schizophrenia, survey

  11. Pedro de Castañeda: su pintura para el refectorio del Colegio Mayor de San Ildefonso (1553

    Directory of Open Access Journals (Sweden)

    González Ramos, Roberto

    2003-09-01

    Full Text Available El pintor Pedro de Castañeda es un artista poco conocido, activo en la zona de Alcalá de Henares en las décadas centrales del siglo XVI. Se sabe que junto a su hijo Juan fue colaborador del entallador y traductor de Vitruvio Miguel de Urrea. Pedro de Castañeda pintó un cirial que había tallado Urrea para la iglesia parroquial de Camarma de Esteruelas, trabajo por el que ambos cobraron cierta cantidad en 1540, y en 1550 colaboró con ese entallador y con Claudio de Arciniega, ayudado por Juan, en la obra de los retablos colaterales de la iglesia de Daganzo de Arriba (perdidos, realizando su pintura. Parece que se trata del mismo artista el Pedro Castañeda que se documenta trabajando en la zona de Segovia, concretamente en dos retablos para la iglesia de Cascajares del Fresno. Falleció en 1557…

  12. Cryopreservation of chayote (Sechium edule JACQ. SW.) zygotic embryos and shoot-tips from in vitro plantlets.

    Science.gov (United States)

    Abdelnour-Esquivel, Ana; Engelmann, Florent

    2002-01-01

    This paper presents the development of cryopreservation protocols for zygotic embryos and apices of chayote (Sechium edule Jacq. Sw.), a tropical plant species with recalcitrant seeds. Zygotic embryos of two cultivars, Ccocro negro (CN) and Claudio (Cl) could withstand cryopreservation, with survival percentages of 10 and 30 %, after desiccation to 23 and 19 % moisture content (fresh weight basis), respectively. Apices sampled on in vitro plantlets of cultivars Cl, 13 and JM were successfully cryopreserved using a vitrification technique. Optimal conditions included the culture of mother-plants for 22 days on medium containing 0.3 M sucrose, culture of excised apices on the same medium for 1 day, loading of apices for 20 min with 2M glycerol + 0.4M glycerol, treatment with a series of diluted PVS2 solution (60 % PVS2 followed by 80 % PVS2 solution for 15 min (cultivar Cocoro Blanco [CB]) or 30 min (cultivars CN and Cl) at each concentration), rapid freezing and thawing, washing of shoot-tips with a 1.2 M sucrose solution, followed by recovery on media with progressively decreasing sucrose concentrations until the standard concentration of 0.1 M was reached. The highest survival percentages achieved ranged between 17 and 38 %, depending on the cultivar.

  13. Destiny Transform in the Ethical Confusion and Reconstruction of Ethical Order of Measure for Measure%《一报还一报》的伦理混乱与秩序重构中的悲喜命运转向

    Institute of Scientific and Technical Information of China (English)

    刘玉杰; 黄晓洁

    2014-01-01

    莎士比亚《一报还一报》一剧以克劳狄奥与朱丽叶的婚前私通为主要伦理线,展示了维也纳法治下个人私通和公共淫乱两类人的跌宕命运,着重探讨了维也纳城的伦理混乱,以及在主政者的伦理秩序重构中个人私通者由悲而喜和公共淫乱者由喜而悲的命运转向,旨在指出在西方前现代社会中,对基督教伦理规范的认同与否决定着个人的命运转向。%Claudio and Juliet’ s adultery is the main ethical line of William Shakespeare’ s drama Measure for Measure. The drama demonstrates adulterer and whoremonger’ s destiny transform under Vienna’ s nomocracy. This paper focuses on Vienna’ s ethical con-fusion, adulterer’ s tragic fate transform to comedy fate,while whoremonger’ s comedy fate transform to tragic fate. Aims to point out that , in the pre-modern western society, whether identity for Christian ethics determines the fate of the individual.

  14. A note of thanks

    Directory of Open Access Journals (Sweden)

    Stefania Boccia

    2013-12-01

    Full Text Available The editors-in-chief, editors, members of the editorial board and publisher of Epidemiology, Biostatistics and Public Health wish to express their sincere gratitude to the referees of the articles considered for the 2013 volume of the Journal. Giuseppe Arbia Fabio Barbone Joana Bastos Stefania Boccia Anna BossiSilvio BrusaferroChiara CadedduCaterina CaminitiGiovanni CapelliGuido CitoniGianfranco DamianiAntonio De BelvisEmma De FeoElisabetta De VitoChiara de WaureDomitilla Di ThieneAna DuarteBruno Federico Monica Ferraroni Alessandra Frustaci Carlotta Galeone Silvano Gallus Maurizio Genuardi Guglielmo Giraldi Maria Rosaria Gualano Carolina Ianuale Farhad Islami Giuseppe La Torre Patrizia Laurenti Laura Lauria Carlo La Vecchia Emanuele Leoncini Alice Mannocci Walter Mazzucco Silvia Miccoli Cristina Montomoli Eva Negri Nicola Nicolotti Caterina Palazzo GianCarlo Paradisi Patrizio Pasqualetti Claudio Pelucchi Brunella Posteraro Delphine Praud Gianluigi Quaranta Luca Sbrogiò Benedetto Simone Giuliana Solinas Maria Lucia Specchia Annamaria Tortorano Fabio TuroneBrigid UnimMaria Assunta Veneziano Francesco Vitale Antonella Zambon Alessandro Zanetti.

  15. Life-threatening asthma attack during prolonged fingolimod treatment: case report

    Directory of Open Access Journals (Sweden)

    Zecca C

    2014-07-01

    Full Text Available Chiara Zecca,1,* Matteo Caporro,1,* Sandor Györik,2 Claudio Gobbi11Neurocenter of Southern Switzerland, Department of Neurology, Ospedale Regionale di Lugano, Lugano, Switzerland; 2Department of Internal Medicine, Ospedale Regionale di Bellinzona, Bellinzona, Switzerland*These authors contributed equally to this workBackground: Fingolimod (FTY mediates bronchoconstriction by interacting with sphingosine-1-phosphate receptors. The majority of the reported adverse respiratory events occur during the first weeks of treatment.Case presentation: A 49-year-old woman developed a life-threatening asthma attack after 6 months of continuous FTY treatment. The adverse event required prolonged hospitalization, and the patient recovered without sequelae after FTY interruption. A history of previous airway hyperreactivity and a concurrent viral respiratory infection possibly acted as predisposing factors.Conclusion: This first description of a severe, life-threatening asthma attack during prolonged FTY treatment suggests the need for long-term clinical surveillance, especially in patients with known predisposing factors.Keywords: multiple sclerosis, bronchial hyper-reactivity

  16. Role of Ocrl1 and Inpp5E in primary cilia assembly and maintenance: a phosphatidylinositol phosphatase relay system?

    Directory of Open Access Journals (Sweden)

    Madhivanan K

    2016-02-01

    Full Text Available Kayalvizhi Madhivanan,* Swetha Ramadesikan,* R Claudio Aguilar Department of Biological Sciences, Purdue University, West Lafayette, IN, USA *These authors contributed equally to this work Abstract: The primary cilium (PC is a plasma membrane-derived structure of great importance for cell and organismal physiology. Indeed, abnormalities in assembly or function of the PC trigger the onset of a group of genetic diseases collectively known as ciliopathies. In recent years, it has become evident that the integrity and function of the PC depends substantially on signaling elements such as phosphoinositides (PI and their regulators. Because phospholipids such as PI(4,5P2 constitute recruitment platforms for cytoskeleton, signaling, and trafficking machinery, control over their levels is critical for PC function. Although information about phosphoinositol phosphate (PIP kinases in the PC is scarce, a growing body of evidence supports a role for PIP phosphatases in cilia assembly/maintenance. Indeed, deficiencies in two 5′ PIP phosphatases, Inpp5E and Ocrl1, are clearly linked to ciliopathies like Joubert/MORM syndromes, or ciliopathy-associated diseases like Lowe syndrome. Here, we review the unique roles of these proteins and their specific site of action for ensuring ciliary integrity. Further, we discuss the possibility that a phosphatase relay system able to pass PI control from a preciliary to an intraciliary compartment is in place to ensure PC integrity/function. Keywords: primary cilia, Ocrl1, Inpp5E, Pip2, Pip3

  17. Procedure for obtaining visas for Switzerland and France

    CERN Multimedia

    2006-01-01

    Signature Rights In accordance with the Status Agreements with CERN, Switzerland and France facilitate the entry of members of the Organization's personnel on to their territories. Where relevant, detailed procedures for obtaining visas apply. Within the framework of those procedures, only the following individuals are authorised to initiate the note verbale procedure as well as to sign the Official Invitation Letters and the Protocoles d'accueil. Oliver BRÜNING Philip BRYANT Lyndon EVANS John FERGUSON David JACOBS Catherine JONES Hélène HALLER-MAUGER Michelle MAZERAND Chris ONIONS Claudio PARRINELLO The French and Swiss Authorities will reject any request signed by a person who is not on this list. We would like to remind you that in accordance with the memorandum of 7 December 2000 issued by the Director of the Administration, (ref. DG/DA/00-119), 'the Organization shall not request any legitimisation document (or residence permit) or visa from the Host States for persons registered as EXTERNAL' (p...

  18. Cine Club

    CERN Document Server

    Cine Club

    2012-01-01

    Thursday 10 January 2013 at 20:00 CERN Council Chamber Viridiana Directed by Luis Buñuel (Spain/Mexico, 1961) With: Silvia Pinal, Fernando Rey, Francisco Rabal Original version spanish; english subtitles; 90 minutes Viridiana, a young novice about to take her final vows as a nun, accedes to a request from her widowed uncle to visit him. Moved purely by a sense of obligation, she does so. Her uncle is moved by her resemblance to his late wife to attempt to seduce Viridiana, and tragedy ensues. In the aftermath, Viridiana tries to assuage her guilt by creating a haven for the destitute folk who live around her uncle’s estate. But from these good intentions, too, comes little good. Simon of the Desert Directed by Luis Buñuel (Spain/Mexico, 1965) With: Silvia Pinal, Claudio Brook, Enrique Alvarez Félix Original version spanish; english subtitles; 45 minutes Simon, a deeply religious man living in the 4th century, wants to be nearer to God so he climbs a c...

  19. Technological process for production of persimmon and strawberry vinegars

    Directory of Open Access Journals (Sweden)

    Claudio Hidalgo

    2010-08-01

    Full Text Available Claudio Hidalgo1, Estibaliz Mateo1, Ana Belen Cerezo2, Maria-Jesús Torija1, Albert Mas11Biotecnologia Enològica, Departament de Bioquimica i Biotecnologia, Facultat d’Enologia, Universitat Rovira i Virgili, Marcel-li Domingo, Tarragona; 2Área de Nutrición y Bromatología, Facultad de Farmacia, Universidad de Sevilla, Sevilla, SpainAbstract: Fruit surplus is common in intensive agriculture in many countries. This ecologic and economic problem requires alternative uses to be found for fruit. The aim of this study was to use surplus fruit to produce vinegar by traditional methods (alcoholic fermentation and acetification from persimmon and strawberry. The process was performed with naturally occurring microorganisms and compared with inoculated commercial wine yeast for alcoholic fermentation. Alcoholic fermentation proceeded faster when inoculated due to the length of the lag phases observed in spontaneous fermentations. The alcoholic fermentations of strawberry mash were faster than those of persimmon mash. In contrast, acetifications were much faster in persimmon (30 days than in strawberry (70 days, in the latter some acetifications were not finished. From the technologic point of view, to produce persimmon and strawberry wine and vinegar, it is better to avoid fruit pressing and perform the process with fruit mash. Inoculation is recommended for persimmon and is necessary for strawberry.Keywords: wine, vinegar, fruit seasonings, acetic acid bacteria

  20. Development of oral agent in the treatment of multiple sclerosis: how the first available oral therapy, Fingolimod will change therapeutic paradigm approach

    Directory of Open Access Journals (Sweden)

    Gasperini C

    2012-07-01

    Full Text Available Claudio Gasperini,1 Serena Ruggieri21Department of Neurosciences, S Camillo Forlanini Hospital, 2Department of Neurology and Psychiatry, University of Rome “Sapienza,” Rome, ItalyAbstract: Multiple sclerosis (MS is a chronic inflammatory disorder of the central nervous system, traditionally considered to be an autoimmune, demyelinating disease. Based on this understanding, the initial therapeutic strategies were directed at immune modulation and inflammation control. At present, there are five licensed first-line disease-modifying drugs and two second-line treatments in MS. Currently available MS therapies have shown significant efficacy throughout many trials, but they produce different side-effect profiles in patients. Since they are well known and safe, they require regular and frequent parenteral administration and are associated with limited long-term treatment adherence. Thus, there is an important need for the development of new therapeutic strategies. Several oral compounds are in late-stage development for treating MS. Fingolimod (FTY720; Novartis, Basel, Switzerland is an oral sphingosine-1-phosphase receptor modulator which has demonstrated superior efficacy compared with placebo and interferon β-1a in Phase III studies and has been approved in the treatment of MS. We summarily review the oral compounds in study, focusing on the recent development, approval and the clinical experience with FTY720.Keywords: multiple sclerosis, oral compounds, fingolimod, fty720, sphingosine 1, phosphate, patient satisfaction

  1. Advances in the treatment of relapsing–remitting multiple sclerosis – critical appraisal of fingolimod

    Directory of Open Access Journals (Sweden)

    Gasperini C

    2013-03-01

    Full Text Available Claudio Gasperini,1 Serena Ruggieri,2 Chiara Rosa Mancinelli,2 Carlo Pozzilli2 1Department of Neurosciences, S Camillo Forlanini Hospital, Rome, Italy; 2Department of Neurology and Psychiatry, Sapienza – University of Rome, Rome, Italy Abstract: Multiple sclerosis (MS is a chronic inflammatory disorder of the central nervous system, traditionally considered to be an autoimmune, demyelinating disease. Based on this understanding, initial therapeutic strategies were directed at immune modulation and inflammation control. At present, there are five licensed first-line disease-modifying drugs for MS in Europe, and two second-line treatments. Currently available MS therapies have shown significant efficacy throughout many trials, but they produce different side effects. Despite disease-modifying drugs being well known and safe, they require regular and frequent parenteral administration and are associated with limited long-term treatment adherence. Therefore, the development of new therapeutic strategies is warranted. Several oral compounds are in late stages of development for treating MS. Fingolimod is an oral sphingosine-1-phosphate receptor modulator that has demonstrated superior efficacy compared with placebo and interferon β-1a in phase III studies. It has already been approved in the treatment of MS. This review focuses on advances in current and novel oral treatment approaches in MS. We summarily review the oral compounds in this study, focusing on the recent development, approval, and the clinical experience with fingolimod. Keywords: multiple sclerosis, oral compounds, fingolimod, sphingosine-1-phosphate, patient satisfaction, adherence

  2. From Easter Island to coated coronary stents: a remarkable saga.

    Science.gov (United States)

    Cantwell, John D

    2008-01-01

    Easter Island, even though it's in the middle of nowhere, is indeed a piece of the continent, as John Donne alluded to. In addition to contributing rapamycin to the medical field, the island is an example to the whole world of the consequences of affluent lifestyles, tribal wars, and ignorance of ecology. Jared Diamond expressed these thoughts best in his book, "Collapse:" The parallels between Easter Island and the whole modern world are chillingly obvious... All countries on earth today share resources and affect each other just as did Easter's dozen clans. Polynesian Easter Island was as isolated in the Pacific Ocean as the Earth is today in space. People see the collapse of Easter Island 's society as a metaphor; a worst-case scenario, for what may lie ahead for us in our own future. Some veteran Easter Island archaeologists like Claudio Cristina feel that Diamond's views are overly simplistic, commenting that he only spent a week on the island (versus 30 years for Cristina). Predatory Polynesian rats, earthquakes, tsunamis, variations in rainfall, diseases introduced by European sailing ships, could all have contributed to the near-demise of Easter Island. Tribal wars certainly didn't help, nor did slave-raiding parties from Peru. Only the eyes of the moai (Fig. 5) have seen it all, but the statues remain silent, as they have for over 1,000 years.

  3. España Republicana, una lectura de la Guerra Civil desde Argentina

    Directory of Open Access Journals (Sweden)

    María Teresa Pochat

    2006-11-01

    Full Text Available España Republicana was the organ of press of the Centro Republicano Español de Buenos Aires that, between 1918 and 1964, was essential means for the communication from the news of Spain in political, cultural, economic and social matters. In addition to constitute a scope of information, it gave rise to the dialogue between Spanish organizations of Argentina and it served like vehicle at the time of reuniting material of aid at the hardest moments of the Civil War and the postwar period. In its pages, the most outstanding personalities of the Republic appear like protagonists, mentioned in direct speech, in the heat of decision making and, often, like signers of collaborations dedicated in exclusive right to be published in the newspaper. Given the important as that España Republicana acted during the Civil War, we have believed useful to present in this monographic number the details of a work that comprised of an ample project of investigation of archives that it develops the Spanish Ministry of Culture, in collaboration with the Foundation "Claudio Sánchez-Albornoz". In synthesis, the task consisted of the microshooting and elaboration of an index commented of each one of more than thousand numbers available of the publication, with a detailed registry of contents, names and institutions, among other considered aspects, in order to facilitate to the investigators worldwide the location of the data of its interest.

  4. Behaviour of the Sm-Nd and Rb-Sr systems of the mafic-ultramafic layered sequence from Ribeirao dos Motas (Archaean), meridional craton Sao Francisco: evidences of mantle source enrichment and isotopic fractionation; Comportamento dos sistemas Sm-Nd e Rb-Sr da sequencia acamadada mafico-ultramafico Ribeirao dos Motas (Arqueano), craton Sao Francisco Meridional: evidencias de enriquecimento mantelico e fracionamento isotopico

    Energy Technology Data Exchange (ETDEWEB)

    Carneiro, Mauricio Antonio; Carvalho Junior, Irneu Mendes de; Oliveira, Arildo Henrique de [Ouro Preto Univ., (UFOP), MG (Brazil). Dept. de Geologia]. E-mail: mauricio@degeo.ufop.br; Teixeira, Wilson [Sao Paulo Univ., SP (Brazil). Inst. de Geociencias. Dept. de Mineralogia e Geotectonica; Pimentel, Marcio Martins [Brasilia Univ., DF (Brazil). Inst. de Geociencias. Lab. de Geocronologia

    2004-10-15

    The Ribeirao dos Motas layered sequence (SARM) crops out in the southern part of the Sao Francisco Craton, Brazil. This sequence comprises phaneritic meta ultramafic and metamafic rocks, which, although slightly deformed and metamorphosed, retain primary igneous layers. Porphyritic rocks with idiomorphic pyroxene crystals and heteradcumulate and adcumulate textures are also present. Eighteen isotopic analyses were performed in the SARM, comprising rocks with primary (relict) textures, as well as rocks in amphibolite facies and retro-metamorphosed to green-schist facies. Seven samples yield a Sm/Nd isochron age of 2.79 +- 0.30 Ga (MSWD=1.2 e epsilon {sub Ndt}=+0.48), constraining the accretion time of the SARM rocks. The positive epsilon {sub Ndt} value coupled with the Rb/Sr evidence is consistent with mantle source relatively enriched in Nd and Sr isotopes. Nevertheless, some SARM samples display isotopic fractionation and disturbance, which can be ascribed to the following processes or their combinations: a) mobilization of the incompatible elements due to regional high grade metamorphism; b) isotopic changes during upper amphibolite facies overprint; c) isotopic resetting by low-grade fluids associated to the Claudio Shear zone, which is located nearby the SARM. (author)

  5. 亚洲艺术:走向全球的契机与可能——专访策展人陆蓉之

    Institute of Scientific and Technical Information of China (English)

    杨涓

    2011-01-01

    由北京今日美术馆,台北晟铭(UNEEC)文化教育基金会,鹿特丹世界艺术馆和台湾美术馆与威尼斯Claudio Buziol(克劳迪欧·布几奥)基金会联手合作,共同推出《未来通行证——从亚洲到全球》国际大展。此次展览呼应了第54届威尼斯国际艺术展的主题"ILLUMInations"(启发、光照与国家),展现了亚洲在艺术发展中,不止超越了国界,同时成为一个新的艺术宇宙中心。该展览分为两个部分,分别于Abbazia di San Gregorio(圣格雷戈斯修道院)以及Palazzo Mangilli-Valma

  6. The Origins of Kaldor Public Art Projects

    Directory of Open Access Journals (Sweden)

    Rebecca Coates

    2015-05-01

    Full Text Available Christo and Jeanne-Claude’s Wrapped Coast – One Million Square Feet, Little Bay, Sydney, Australia (1968-69 remains one of Kaldor Public Art Projects’ (KPAP most significant projects, both artistically and in its impact on the local and international art scene. A private not-for-profit foundation, Kaldor Public Art Projects has presented site-specific temporary art projects by leading international contemporary artists in Australia for over forty years. Some of these projects, such as Christo and Jeanne-Claude’s, were important milestones in the development of contemporary art in Australia. Not-for-profit foundations now play an increasingly important and visible role in the contemporary art world. This essay considers the circumstances that surrounded the inception of one of the earliest of these foundations, Kaldor Public Art Projects. It considers the factors that led to its creation. These include John Kaldor’s upbringing and experience as an émigré in Australia; his mentors, Sir Nicholas Sekers and Claudio Alcorso; and the influences on and of his collecting interests. The essay argues that gallerists such as Ileana Sonnabend played a pivotal role in the development of Kaldor’s collection and artistic interests. Kaldor’s collecting interests also played a key role in the development of the Art Projects. The role of the collector and patron are inextricably linked.

  7. Carlo Rubbia, former CERN Director-General, appointed Senator for life by the President of Italy.

    CERN Multimedia

    Antonella Del Rosso

    2013-01-01

    Today, the President of the Italian Republic Giorgio Napolitano appointed four new senators for life: the music director and conductor “maestro” Claudio Abbado, the neuroscientist Professor Elena Cattaneo, the renowned architect Renzo Piano and Professor Carlo Rubbia, who was CERN Director-General from 1989 to 1993.   Carlo Rubbia during his talk for the discovery of the W particle in 1983. In 1984, Carlo Rubbia, then head of the UA1 collaboration, was awarded the Nobel Prize in Physics, together with Simon van der Meer, for the discovery of the W and Z particles – at that time two important missing components of the Standard Model. During his term of office as Director-General, the Large Electron Positron collider was inaugurated and the four LEP experiments produced their first results. He also mounted the case for the new Large Hadron Collider, which in 2012 led to the discovery of a Higgs boson. In 1993, the last year of his mandate, the World Wide Web proto...

  8. Resistance to Soil-borne cereal mosaic virus in durum wheat is controlled by a major QTL on chromosome arm 2BS and minor loci.

    Science.gov (United States)

    Maccaferri, Marco; Ratti, Claudio; Rubies-Autonell, Concepcion; Vallega, Victor; Demontis, Andrea; Stefanelli, Sandra; Tuberosa, Roberto; Sanguineti, Maria Corinna

    2011-08-01

    Soil-borne cereal mosaic (SBCM) is a viral disease, which seriously affects hexaploid as well as tetraploid wheat crops in Europe. In durum wheat (Triticum durum Desf.), the elite germplasm is characterized by a wide range of responses to SBCMV, from susceptibility to almost complete resistance. In this study, the genetic analysis of SBCMV resistance was carried out using a population of 181 durum wheat recombinant inbred lines (RILs) obtained from Meridiano (resistant) × Claudio (moderately susceptible), which were profiled with SSR and DArT markers. The RILs were characterized for SBCMV response in the field under severe and uniform SBCMV infection during 2007 and 2008. A wide range of disease reactions (as estimated by symptom severity and DAS-ELISA) was observed. A large portion of the variability for SBCMV response was explained by a major QTL (QSbm.ubo-2BS) located in the distal telomeric region of chromosome 2BS near the marker triplet Xbarc35-Xwmc661-Xgwm210, with R(2) values ranging from 51.6 to 91.6%. The favorable allele was contributed by Meridiano. Several QTLs with minor effects on SBCMV response were also detected. Consistently with the observed transgressive segregation, the resistance alleles at minor QTLs were contributed by both parents. The presence and effects of QSbm.ubo-2BS were validated through association mapping in a panel of 111 elite durum wheat accessions.

  9. Thermal and lighting perception in four fully glazed office buildings in Santiago, Chile

    Directory of Open Access Journals (Sweden)

    Claudio Vásquez

    2013-12-01

    Full Text Available Corresponding author: Claudio Vásquez, School of Architecture, Catholic University of Chile. 1916 El Comendador str. Providencia, Santiago, ZIP: 7530091, Chile. Tel.: +56 9 92826305; E-mail: clvasque@uc.cl This paper is part of a general research project whose main objective is to establish a baseline for post-occupancy energy consumption and indoor environmental quality for office buildings in Santiago, Chile. This study aims at understanding how architectonical variables relate to, and can even determine, user comfort perception. Thus, one-year continuous monitoring in several floors at four office buildings was performed and seasonal surveys were completed. Survey participants were asked a series of questions regarding spatial orientation and comfort perception in their workspace. The data from the comfort survey and onsite measurements such as season of the year, case study, type of workspace and possibility of an outdoor view from the workstation were contrasted with the components obtained by a Principal Component Analysis (PCA. Three components were selected from the PCA, and three Maps of Perception (MP were produced. These maps were then analyzed and interpreted so as to obtain information on the general perception of thermal and lighting comfort at workspaces within several office buildings in Santiago.

  10. Highlights and Conclusions of the Chalonge 13th Paris Cosmology Colloquium

    CERN Document Server

    de Vega, H J

    2010-01-01

    The 13th Chalonge Paris Cosmology Colloquium was held at the historic Perrault building of Observatoire de Paris on 23-25 July 2009. The Colloquium was held in the spirit of the Chalonge School, putting together real cosmological and astrophysical data and hard theory predictive approach in the framework of the Standard Model of the Universe. Peter Biermann, James Bullock, Claudio Destri, Hector de Vega, Massimo Giovannini, Sasha Kashlinsky, Eiichiro Komatsu, Anthony Lasenby and Norma G. Sanchez present here their highlights of the Colloquium. The summary and conclusions by H. J. de Vega, M. C. Falvella and N. G. Sanchez stress among other points: (i) the primordial CMB fluctuations are almost gaussian, large primordial non-gaussianity and large running index are strongly disfavored. The primordial graviton ratio r is predicted in the effective theory of inflation to be between 0.021 and 0.053, at reach of the next CMB observations. (ii) Dark energy observations are consistent with the cosmological constant. ...

  11. Perfil cardiovascular em pacientes com apneia obstrutiva do sono

    Directory of Open Access Journals (Sweden)

    Fátima Dumas Cintra

    2011-04-01

    Full Text Available FUNDAMENTO: Apneia Obstrutiva do Sono (AOS é um fator de risco para várias condições cardiovasculares incluindo aumento na mortalidade cardiovascular. Sendo assim, é essencial o conhecimento das principais repercussões cardiovasculares dos distúrbios respiratórios do sono durante uma avaliação clínica. OBJETIVO: Analisar as características cardiovasculares de pacientes com AOS. MÉTODOS: Pacientes submetidos a polissonografia basal foram consecutivamente selecionados do banco de dados do Instituto do Sono entre março de 2007 e março de 2009. Todos os pacientes foram orientados a comparecer ao ambulatório para coleta de sangue, exame físico, eletrocardiograma de 12 derivações, espirometria, teste cardiopulmonar em esteira ergométrica e ecocardiograma transtorácico. O estudo foi aprovado pelo comitê de ética e pesquisa e registrado no site http://clinicaltrials.gov/ sob o número: NCT00768625. RESULTADOS: Foram analisados 261 pacientes e 108 controles. As principais características dos pacientes com AOS foram: obesidade, hipertensão, baixos níveis plasmáticos de lipoproteínas de alta densidade (HDL e aumento no diâmetro do átrio esquerdo quando comparados com controles (3,75 ± 0,42; 3,61 ± 0,41, p = 0,001, respectivamente. Essas características associadas correspondem a um acréscimo de 16,6 vezes na probabilidade de ocorrência de AOS independentemente do relato de algum sintoma dessa desordem, como sonolência ou ronco. CONCLUSÃO: Na amostra avaliada, o perfil cardiovascular dos pacientes com AOS mais encontrado foi: obesidade, hipertensão arterial, baixos níveis plasmáticos de HDL e átrio esquerdo com diâmetro aumentado.

  12. Is the population properly informed about sleep disorders? A população está devidamente informada sobre os distúrbios do sono?

    Directory of Open Access Journals (Sweden)

    Eleida Pereira Camargo

    2013-01-01

    Full Text Available OBJECTIVE: To measure the prior knowledge about sleep disorders and patient's ability to report their problems adequately to health professionals. METHODS: We analyzed 208 patient's records and extracted the following information: date of birth, gender, medical diagnostic hypotheses, patient's primary complaint in their words, considering the most appropriated semantic approximation to the perceptual phenomena, either by their own or by reasoning information from the partner. We compared the agreement (Kappa's test between patient's complaint and medical diagnosis. The 95% confidence interval was used to analyze proportions. RESULTS: We found strong correlations for bruxism; moderate for snoring, insomnia, nightmares, somniloquy, and restless legs syndrome; fair for excessive movement during sleep (EMDS and obstructive sleep apnea syndrome (OSA. CONCLUSIONS: The observed correlations were heterogeneous, but important diseases such as OSA and EMDS in children showed fair and weak correlations. This suggests an unsatisfactory knowledge level among the population about these disorders, despite their high prevalence and impact on patient's overall health.OBJETIVO: Avaliar o conhecimento da população investigada sobre os distúrbios do sono e sua capacidade de reportá-los adequadamente aos profissionais de saúde. MÉTODOS: Foram analisados ​​208 prontuários de pacientes, dos quais foram extraídos os seguintes dados: data de nascimento, sexo, hipótese diagnóstica médica e queixa principal do paciente. Foram comparadas as queixas e as hipóteses diagnósticas, considerando-se o intervalo de confiança de 95% para as proporções entre estas variáveis, determinando-se sua concordância por meio do teste Kappa. RESULTADOS: Foram encontradas concordâncias acentuadas em relação ao bruxismo; moderadas para ronco, insônia, pesadelos, sonilóquio e síndrome das pernas inquietas; concordância regular para movimentação excessiva durante o

  13. Is the population properly informed about sleep disorders? A população está devidamente informada sobre os distúrbios do sono?

    Directory of Open Access Journals (Sweden)

    Eleida Pereira Camargo

    2013-02-01

    Full Text Available OBJECTIVE: To measure the prior knowledge about sleep disorders and patient's ability to report their problems adequately to health professionals. METHODS: We analyzed 208 patient's records and extracted the following information: date of birth, gender, medical diagnostic hypotheses, patient's primary complaint in their words, considering the most appropriated semantic approximation to the perceptual phenomena, either by their own or by reasoning information from the partner. We compared the agreement (Kappa's test between patient's complaint and medical diagnosis. The 95% confidence interval was used to analyze proportions. RESULTS: We found strong correlations for bruxism; moderate for snoring, insomnia, nightmares, somniloquy, and restless legs syndrome; fair for excessive movement during sleep (EMDS and obstructive sleep apnea syndrome (OSA. CONCLUSIONS: The observed correlations were heterogeneous, but important diseases such as OSA and EMDS in children showed fair and weak correlations. This suggests an unsatisfactory knowledge level among the population about these disorders, despite their high prevalence and impact on patient's overall health.OBJETIVO: Avaliar o conhecimento da população investigada sobre os distúrbios do sono e sua capacidade de reportá-los adequadamente aos profissionais de saúde. MÉTODOS: Foram analisados ​​208 prontuários de pacientes, dos quais foram extraídos os seguintes dados: data de nascimento, sexo, hipótese diagnóstica médica e queixa principal do paciente. Foram comparadas as queixas e as hipóteses diagnósticas, considerando-se o intervalo de confiança de 95% para as proporções entre estas variáveis, determinando-se sua concordância por meio do teste Kappa. RESULTADOS: Foram encontradas concordâncias acentuadas em relação ao bruxismo; moderadas para ronco, insônia, pesadelos, sonilóquio e síndrome das pernas inquietas; concordância regular para movimentação excessiva durante o

  14. KULTURisk regional risk assessment methodology for water-related natural hazards - Part 2: Application to the Zurich case study

    Science.gov (United States)

    Ronco, P.; Bullo, M.; Torresan, S.; Critto, A.; Olschewski, R.; Zappa, M.; Marcomini, A.

    2015-03-01

    The aim of this paper is the application of the KULTURisk regional risk assessment (KR-RRA) methodology, presented in the companion paper (Part 1, Ronco et al., 2014), to the Sihl River basin, in northern Switzerland. Flood-related risks have been assessed for different receptors lying on the Sihl River valley including Zurich, which represents a typical case of river flooding in an urban area, by calibrating the methodology to the site-specific context and features. Risk maps and statistics have been developed using a 300-year return period scenario for six relevant targets exposed to flood risk: people; economic activities: buildings, infrastructure and agriculture; natural and semi-natural systems; and cultural heritage. Finally, the total risk index map has been produced to visualize the spatial pattern of flood risk within the target area and, therefore, to identify and rank areas and hotspots at risk by means of multi-criteria decision analysis (MCDA) tools. Through a tailored participatory approach, risk maps supplement the consideration of technical experts with the (essential) point of view of relevant stakeholders for the appraisal of the specific scores weighting for the different receptor-relative risks. The total risk maps obtained for the Sihl River case study are associated with the lower classes of risk. In general, higher (relative) risk scores are spatially concentrated in the deeply urbanized city centre and areas that lie just above to river course. Here, predicted injuries and potential fatalities are mainly due to high population density and to the presence of vulnerable people; flooded buildings are mainly classified as continuous and discontinuous urban fabric; flooded roads, pathways and railways, most of them in regards to the Zurich central station (Hauptbahnhof) are at high risk of inundation, causing severe indirect damage. Moreover, the risk pattern for agriculture, natural and semi-natural systems and cultural heritage is relatively

  15. The KULTURisk Regional Risk Assessment methodology for water-related natural hazards - Part 2: Application to the Zurich case study

    Science.gov (United States)

    Ronco, P.; Bullo, M.; Torresan, S.; Critto, A.; Olschewski, R.; Zappa, M.; Marcomini, A.

    2014-07-01

    The main objective of the paper is the application of the KULTURisk Regional Risk Assessment (KR-RRA) methodology, presented in the companion paper (Part 1, Ronco et al., 2014), to the Sihl River valley, in Switzerland. Through a tuning process of the methodology to the site-specific context and features, flood related risks have been assessed for different receptors lying on the Sihl River valley including the city of Zurich, which represents a typical case of river flooding in urban area. After characterizing the peculiarities of the specific case study, risk maps have been developed under a 300 years return period scenario (selected as baseline) for six identified relevant targets, exposed to flood risk in the Sihl valley, namely: people, economic activities (including buildings, infrastructures and agriculture), natural and semi-natural systems and cultural heritage. Finally, the total risk index map, which allows to identify and rank areas and hotspots at risk by means of Multi Criteria Decision Analysis tools, has been produced to visualize the spatial pattern of flood risk within the area of study. By means of a tailored participative approach, the total risk maps supplement the consideration of technical experts with the (essential) point of view of the relevant stakeholders for the appraisal of the specific scores and weights related to the receptor-relative risks. The total risk maps obtained for the Sihl River case study are associated with the lower classes of risk. In general, higher relative risks are concentrated in the deeply urbanized area within and around the Zurich city centre and areas that rely just behind to the Sihl River course. Here, forecasted injuries and potential fatalities are mainly due to high population density and high presence of old (vulnerable) people; inundated buildings are mainly classified as continuous and discontinuous urban fabric; flooded roads, pathways and railways, the majority of them referring to the Zurich main

  16. [THE EFFECTS OF THE PILATES METHOD ON HAMSTRING EXTENSIBILITY, PELVIC TILT AND TRUNK FLEXION].

    Science.gov (United States)

    Vaquero-Cristóbal, Raquel; López-Miñarro, Pedro A; Alacid Cárceles, Fernando; Esparza-Ros, Francisco

    2015-11-01

    Introducción: el Pilates engloba un gran volumen de ejercicios de estiramiento de la musculatura isquiosural y de flexión máxima del tronco con rodillas extendidas. Objetivo: realizar una revisión sistemática sobre los efectos de la práctica de Pilates y de un período de desentrenamiento sobre la flexibilidad isquiosural, la inclinación pélvica y la flexión del tronco en flexión máxima del tronco con rodillas extendidas. Metodología: se analizaron todos los diseños experimentales o cuasi-experimentales redactados en inglés, español o portugués incluidos en las siguientes bases de datos: Pubmed, Sports Discus, ISI Web of Knowledge, Dialnet y Research Gate. Resultados y discusión: fueron analizados veintiún artículos. La mayoría utilizaron un diseño de pre-testpost- test con grupo control, siendo heterogéneos los programas de intervención aplicados. La muestra estaba compuesta principalmente por mujeres, jóvenes y mayores. Se encontró que la práctica de Pilates, con diferente volumen, incrementaba significativamente la extensibilidad isquiosural y la inclinación pélvica en flexión máxima del tronco. Para obtener una mayor inclinación del tronco fueron necesarios, al menos, tres días de entrenamiento semanal durante seis semanas. En los estudios que incluyen poblaciones de deportistas los resultados son contradictorios. Con el desentrenamiento se produce una disminución de la extensibilidad isquiosural y la flexión del tronco a partir de la segunda semana. Conclusiones: existen moderadas evidencias de que el Pilates es efectivo para aumentar la extensibilidad isquiosural, la inclinación pélvica y el grado de flexión del ronco en posiciones de flexión máxima en poblaciones sedentarias y activas recreacionales, así como para incrementar la flexibilidad isquiosural en deportistas.

  17. Achados da avaliação multiprofissional de crianças respiradoras orais

    Directory of Open Access Journals (Sweden)

    Mariana da Costa

    2015-06-01

    Full Text Available OBJETIVO: descrever os achados miofuncionais orofaciais, bem como os principais problemas otorrinolaringológicos, alergológicos e ortodônticos encontrados em crianças com respiração oral. MÉTODOS: análise de prontuários de 502 crianças do Ambulatório do Respirador Oral do Hospital das Clínicas da Universidade Federal de Minas Gerais. Os participantes tinham idades entre 2 e 12 anos (mediana de 6,0 anos, sendo 289 (57,6% do sexo masculino e 213 (42,4% do sexo feminino. Foram coletados dados dos prontuários referentes à anamnese geral, avaliação fonoaudiológica, bem como as partes relevantes das avaliações otorrinolaringológica, alergológica e ortodôntica. Os dados foram submetidos à análise estatística. RESULTADOS: na anamnese, observou-se prevalência significante de permanência de boca aberta (98,0%, ronco (89,9% e sialorreia noturna (68,6%. Na avaliação alergológica, verificou-se teste cutâneo positivo (59% e rinite (57,8% e na otorrinolaringológica, hipertrofia de adenoide (91,7% e amígdalas (72,6%, além de mucosa nasal alterada (60,3%. A avaliação ortodôntica indicou presença de má oclusão (86,8%, perfil facial convexo (62,9% e trespasse vertical aumentado (55,5%. Os dados da avaliação fonoaudiológica indicaram inadequação da posição habitual de lábios (70,5%, tensão de lábios (65,4% e de língua (64,4% alteradas, palato duro alto (57,1%, ângulo nasolabial alterado (57,0% e assimetria facial (55,0%. CONCLUSÃO: verificaram-se alterações nas avaliações realizadas por todos os profissionais, confirmando o grande impacto da respiração oral na qualidade de vida e, portanto, a necessidade de tratamento multidisciplinar para esses pacientes.

  18. Estudo comparativo da história clínica e da polissonografia na síndrome da apnéia/ hipopnéia obstrutiva do sono Comparative study between clinical history and polysomnogram in the obstructive sleep apnea/ hypopnea syndrome

    Directory of Open Access Journals (Sweden)

    Lys Maria Allenstein Gondim

    2007-12-01

    Full Text Available O reconhecimento dos distúrbios respiratórios do sono tem aumentado a cada ano. Manifestações, como o ronco, consideradas meros incômodos vêm adquirindo importância no que diz respeito à qualidade de vida e seu impacto social. OBJETIVO: Comparar a história clínica com os resultados da polissonografia (PSG, na Síndrome da Apnéia/Hipopnéia Obstrutiva do Sono (SAHOS, é o principal objetivo deste trabalho. MATERIAL E MÉTODOS: Foi realizado um estudo retrospectivo, com 125 pacientes, através da análise de questionários específicos, IMC e Escala de Epworth. RESULTADOS: Dentre os pacientes, 75 eram do sexo masculino e 50 do feminino. O principal sintoma foi a roncopatia. 46% apresentaram PSG normais, 30% SAHOS leve, 15% moderada e 9% severa, não se evidenciando correlação estatística entre a clínica e a PSG. Dentre as queixas, somente a insônia foi relevante, em análise univariada e em pacientes normais e com SAHOS leve (pRecognizing sleep-disordered breathing is on the rise every year. Manifestations, such as snoring, that were earlier considered mere inconvenients are now acquiring greater importance concerning life quality and social impact. AIM OF THE STUDY: To compare the clinical history to polysomnogram (PSG results in the Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS. MATERIALS AND METHODS: 125 patients were analyzed, in a retrospective study. Specific questionnaires, avaliations of Body Mass Index and Epworth Scale were carried out. RESULTS: Among the patients, 75 were males and 50 were females. The main symptom was snoring. 46% had normal PSG, 30% had light OSAHS, 15% moderate and 9% severe OSAHS and it was not observed a correlation between clinical data and PSG results. Concerning clinical symptoms, only insomnia has shown relevance when univariably analyzed in normal and light OSAHS patients (p<0,05 compared to patients with moderate and severe OSAHS, losing its importance when analyzed together with other

  19. Avaliação da qualidade de vida e do sono de atletas paralímpicos brasileiros

    Directory of Open Access Journals (Sweden)

    Andrea Maculano Esteves

    2015-02-01

    Full Text Available INTRODUÇÃO: o esporte paralímpico brasileiro vem ganhando destaque no cenário mundial e, com isso, a avaliação de variáveis que possam influenciar positivamente no desempenho desses atletas é de suma importância para o acompanhamento durante o seu período de treinamento. OBJETIVO: avaliar a qualidade de vida e do sono de atletas paralímpicos brasileiros. MÉTODOS: foram estudados 49 atletas paralímpicos das modalidades natação (n=20 e atletismo (n=29. Os atletas responderam a questionários que avaliaram seu padrão e queixas de sono e qualidade de vida. RESULTADOS: a maioria dos atletas (65,30% relatou má qualidade do sono, visto que a latência do sono neste grupo foi significativamente maior do que em atletas com boa qualidade de sono. Cinquenta por cento dos atletas relataram o desejo de fazer mudanças em seu horário de sono e 52% gostariam de aumentar o seu tempo de sono. A sonolência diurna excessiva foi observada em 53,06% dos atletas. Quanto às queixas de distúrbios do sono, foram relatados chute ou espasmos das pernas e ronco. Menores índices de qualidade de vida foram encontrados no meio ambiente em comparação com os domínios físicos, psicológicos ou sociais. CONCLUSÕES: os resultados sugerem que a maioria dos atletas apresentou uma má qualidade do sono e, consequentemente, um alto índice de insatisfação com o sono. Além disso, menores escores de qualidade de vida foram encontrados no domínio ambiental, que está relacionado com a segurança física, proteção e condições em casa.

  20. Tratamento da síndrome da apnéia e hipopnéia obstrutiva do sono com aparelhos intrabucais Treatment of obstructive sleep apnea and hipoapnea syndrome with oral appliances

    Directory of Open Access Journals (Sweden)

    Marco Antonio de Oliveira Almeida

    2006-10-01

    Full Text Available A síndrome da apnéia e hipopnéia obstrutiva do sono (SAHOS é um distúrbio que atinge cerca de 4% da população adulta e que, além dos problemas sociais associados ao ronco e à sonolência diurna excessiva, é preocupante pelos quadros de hipertensão pulmonar e insuficiência cardíaca que pode desencadear. REVISÃO E DISCUSÃO: Através de uma revisão de literatura discutiu-se o uso de aparelhos intrabucais para o tratamento dessa patologia, destacando-se a eficácia e as limitações dessa terapia, os principais sintomas clínicos, os principais efeitos colaterais oclusais, o grau de colaboração e o índice de satisfação dos pacientes. CONCLUSÕES: Concluiu-se que a terapia com aparelhos intrabucais deve ser a de primeira escolha para o tratamento de SAHOS de média a moderada, sendo o desconforto dentário, articular e muscular, a hipersalivação e a xerostomia os sintomas clínicos mais freqüentes, com efeitos colaterais oclusais leves que normalmente não geram incômodos aos pacientes, com bom grau de colaboração e alto índice de satisfação.Obstructive sleep apnea and hipoapnea syndrome (OSAHS is a disorder that affects about 4% of the adult population, and besides the social problems associated to snoring and extreme day time sleepiness, it is preoccupying since it may cause pulmonary hypertension and cardiac failure. REVIEW AND DISCUSSION: Through a literature review, we discuss the use of oral appliances to treat this condition, in regards of therapy effectiveness and limitations, main clinical symptoms, major occlusal side effects, rate of improvement and patient satisfaction. CONCLUSIONS: We concluded that the use of oral appliances should be a first choice treatment for mild to moderate OSAHS, being dental, joint and muscular discomforts, hypersalivation and xerostomia, the most frequent clinical symptoms, with light occlusal side effects that normally do not bother the patients, with a good degree of improvement

  1. Fonoaudiologia e apneia do sono: uma revisão Speech therapy and sleepy apnae: a review

    Directory of Open Access Journals (Sweden)

    Erilucia Pereira Santa Rosa

    2010-10-01

    Full Text Available TEMA: a Síndrome da Apneia/Hipopneia Obstrutiva do Sono (SAHOS é definida pela Academia Americana do Sono como a presença de episódios recorrentes de obstrução parcial ou total das vias aéreas superiores durante o sono e manifesta-se como uma redução (hipopneia ou cessação completa (apneia do fluxo aéreo, apesar da manutenção dos esforços inspiratórios. A SAHOS motiva o chamado ronco crônico, sonolência e caracteriza-se pela parada do fluxo aéreo respiratório por pelo menos, 10 segundos. O diagnóstico é realizado através do exame polissonográfico, que consiste no registro simultâneo de atividades do organismo durante a noite, indicando a quantidade de apneias e hipopneias ocorridos e a gravidade da SAHOS. Para sucesso no tratamento desta desordem é fundamental o diagnóstico preciso e correto e a atuação de uma equipe multidisciplinar, estando inserido nela o fonoaudiólogo. OBJETIVO: analisar, através da literatura a interrrelação da Fonoaudiologia e a SAHOS. CONCLUSÃO: aom o referente estudo, podemos identificar a complexidade da SAHOS e mostrar a importância da atuação fonoaudiológica na terapêutica desses pacientes, para uma melhor qualidade de vida.BACKGROUND: the Apnea syndrome / Obstructive Sleepy Hypopnea (SOHAS is define by the American Academy of Sleep with recurrent presence of episodes of partial or total obstruction in the superior airways during sleep, in addition to showing a reduction (hypopnea or complete stoppage (apnea of airflow, although there is an ongoing maintenance of inspiratory efforts. SOHAS motivates the so-called sleepy chronic snoring and sleepiness to dress up by the stop of airflow by at least 10 seconds. The diagnosis is carried out through polysomnographic examination, which consists of the simultaneous recording of body activities during the night, indicating the number of occurring apneas and hypopneas and SOHAS severity. For the successful of disorder treatment it is

  2. Tidal Forms

    Science.gov (United States)

    Bolla Pittaluga, M.; Seminara, G.; Tambroni, N.

    2003-04-01

    Idrauliche, Bologna, 21-23 Settembre. Bolla Pittaluga, M. 2003. Long term morphodynamic equilibrium of tidal channels: the role of overtides, settling lag and sediment supply. Submitted for publication on Water Resour. Res. Lanzoni, S. and Seminara, G. 2002. Long term evolution and morphodynamic equilibrium of tidal channels, J. Geoph. Res. , 107 (C1),1-13. Marani, M., Lanzoni, S., Zandolin, D., Seminara, G. and Rinaldo, A. 2002. Tidal meanders. Water Resour. Res., 38, 1225- 1239. Schuttelaars, H. M. and de Swart, H. E. 1996. An idealized long-term morphodynamic model of a tidal embayment, Eur. J. Mech., B/Fluids, 15, 55-80. Seminara, G. and Tubino, M. 2001. Sand bars in tidal channels. Part one: free bars. J. Fluid Mech., 440, 49-74. Solari, L., Seminara, G., Lanzoni, S., Marani, M. and Rinaldo, A. 2002. Sand bars in tidal channels. Part 2 Tidal meanders, J. Fluid Mech., 451, 203-238. Solari, L. and Toffolon, M. 2001. Equilibrium bottom topography in tidal meandering channel: preliminary results. In: IAHR-RCEM Symposium 2001, Japan. Tambroni, N., Bolla Pittaluga, M. and Seminara, G. 2003 a. Long term morphodynamic equilibrium of tidal channels: experimental observations. Submitted for publication on Water Resour. Res. Tambroni, N., Lanzoni, S and Seminara, G. 2003 b. Effect of tidal flats on tide propagation in convergent channels. EGS meeting , Nice.

  3. Eight years of groundwater monitoring at the building site of the MOSE system for the safeguard of Venice

    Science.gov (United States)

    Casasso, Alessandro; Sethi, Rajandrea; Di Molfetta, Antonio

    2015-04-01

    contrast, no impact was observed in the phreatic aquifer, proving that the combined insulation effect of the slurry wall and the aquiclude was successful in avoiding the depletion of this water body. At the end of the dewatering pumping, the confined aquifer fully recovered, returning to its pristine conditions in a few months. The EC measurements revealed that a de-salinization trend occurred in a portion of the phreatic aquifer, due to the presence of the slurry wall. The results of the monitoring programme brought some useful insights, that could also be applied to other groundwater monitoring programs in large construction works. The ante operam monitoring phase lasted for some 15 months, thus allowing a thorough understanding of the groundwater dynamics over more than an hydrological yearly cycle. A large area was covered to identify the impacted areas with a high level of precision. The short-term groundwater level dynamics have been revealed thanks to continuous measurements in all the monitored wells. EC measurements proved to be a low-cost and valuable tool to study the cycles and the long-term trends of seawater intrusion. References: Attanayake PM, Waterman MK (2006), Identifying environmental impacts of underground construction. Hydrogeology Journal, 14: 1160-1170. DOI: 10.1007/s10040-006-0037-0 Bras RL, Harleman DRF, Rinaldo A, Rizzoli P (2001) Rescuing Venice from a watery grave. Science 291:2315-2316 Casasso A, Di Molfetta A, Sethi R (2014) Groundwater monitoring at a building site of the tidal protection system "MOSE" in the Lagoon of Venice, Italy. Environmental Earth Sciences, in press. DOI: 10.1007/s12665-014-3588-8 Rinaldo A, Nicotina L, Celegon EA, Beraldin F, Botter G, Carniello L, Cecconi G, Defina A, Settin T, Uccelli A, D'Alpaos L, Marani M (2008) Sea level rise, hydrologic runoff, and the flooding of Venice. Water Resources Research 44, W12434. DOI:10.1029/2008wr007195 Strozzi T, Teatini P, Tosi L (2009) TerraSAR-X reveals the impact of the mobile

  4. SAHOS em crianças: perfil clínico e respiratório polissonográfico OSAS in children: clinical and polysomnographic respiratory profile

    Directory of Open Access Journals (Sweden)

    Regina Terse Trindade Ramos

    2006-06-01

    Full Text Available A Síndrome da Apnéia e Hipopnéia Obstrutiva do Sono (SAHOS em crianças conta com uma prevalência estimada de 1-3% e poderá estar associada a alterações neurocognitivas, comportamentais e cardiovasculares. Entretanto, alguns pediatras desconhecem o problema e este estudo poderá facilitar o reconhecimento de SAHOS pelos mesmos. OBJETIVO: Descrever as características clínicas e os índices respiratórios polissonográficos de crianças com SAHOS, em um laboratório de sono, entre janeiro de 2002 a julho de 2003. FORMA DE ESTUDO: Série de casos. MATERIAL E MÉTODO: Avaliaram-se 93 crianças, de 2 a 10 anos de idade, com diagnóstico polissonográfico de SAHOS. Analisaram-se idade, gênero, grupo racial e dados referentes à saúde e sono das crianças. Os dados polissonográficos estudados foram índice de apnéia-hipopnéia, dessaturação da oxihemoglobina e índice de microdespertar. RESULTADOS: O gênero masculino correspondeu a 61,3% dos casos. A média da idade foi de 5,2 ± 2,1 anos. As queixas que mais motivaram a realização do exame foram roncos, em 24,7% e sono inquieto em 24,7%. Condições médicas mais associadas foram rinite alérgica (98,9% e hipertrofia de adenóides (50,6%. Apnéia leve ocorreu em 66% das crianças. A média e o desvio-padrão da saturação mínima de O2 foi de 89,1 ± 3,5 e a do número de microdespertares de 8,4 ± 3,5/hora de sono. CONCLUSÃO: Os resultados chamam atenção para a possibilidade de SAHOS em crianças com rinite alérgica e hipertrofia adenotonsilar, com queixas de ronco e sono inquieto.Obstructive sleep apnea and hypopnea syndrome in children (osas has an estimated prevalence of up to 3% and can be associated with neurocognitive and behavioural abnormalities, and also cardiovascular complications. This study may help pediatricians, who are unaware of the problem, to recognize osas. STUDY DESIGN: series of cases. AIM: to describe the clinical characteristics and polysomnographic

  5. Cost-effectiveness evaluation of escitalopram in major depressive disorder in Italy

    Directory of Open Access Journals (Sweden)

    Mencacci C

    2013-02-01

    Full Text Available Claudio Mencacci,1 Guido Di Sciascio,2 Pablo Katz,3 Claudio Ripellino31Ospedale Fatebenefratelli, Milan, Italy; 2Azienda Ospedaliera Universitaria Consorziale Policlinico di Bari, Bari, Italy; 3CSD Medical Research Srl, Milan, ItalyBackground: Depression has a lifetime prevalence of 10%–25% among women and 5%–12% among men. Selective serotonin reuptake inhibitors (SSRIs are the most used and the most cost-effective treatment for long-term major depressive disorder. Since the introduction of generic SSRIs, the costs of branded drugs have been questioned. The objective of this study was to assess the cost-effectiveness (€ per quality-adjusted life year [QALY] of escitalopram (which is still covered by a patent compared with paroxetine, sertraline, and citalopram, the patents for which have expired.Methods: A decision analytic model was adapted from the Swedish Dental and Pharmaceutical Benefits agency model to reflect current clinical practice in the treatment of depression in Italy in collaboration with an expert panel of Italian psychiatrists and health economists. The population comprised patients with a first diagnosis of major depressive disorder and receiving for the first time one of the following SSRIs: escitalopram, sertraline, paroxetine, and citalopram. The time frame used was 12 months. Efficacy and utility data for the original model were validated by our expert panel. Local data were considered for resource utilization and for treatment costs based on the Lombardy region health service perspective. Several scenario simulations, one-way sensitivity analyses, and Monte Carlo simulations were performed to test the robustness of the model.Results: The base case scenario showed that escitalopram had an incremental cost-effectiveness ratio (ICER of €4395 and €1080 per QALY compared with sertraline and paroxetine, respectively. Escitalopram was dominant over citalopram, which was confirmed by most one-way sensitivity analyses. The

  6. The mediating role of cytokine IL-6 on the relationship of FEV1 upon 6-minute walk distance in chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Baldi S

    2014-10-01

    Full Text Available Simonetta Baldi,1 Paul E Jose,2 Claudio Bruschi,1 Gian Domenico Pinna,3 Roberto Maestri,3 Antonella Rezzani,1 Ezio Bellinzona,1 Claudio Fracchia,1 Elena Dacosto,1 Paola Crotti,1 Silvia Montemartini1 1Department of Pneumology, Scientific Institute of Montescano, Salvatore Maugeri Foundation IRCCS, Montescano, Pavia, Italy; 2School of Psychology, Victoria University, Wellington, New Zealand; 3Department of Biomedical Engineering, Scientific Institute of Montescano, Salvatore Maugeri Foundation IRCCS, Montescano, Pavia, ItalyObjectives: To explore the mediating role of protein interleukin-6 (IL-6 on the relationship between forced expiratory volume in 1 second (FEV1 and 6-minute walk distance (6MWD and, further, to determine whether status variables (such as age, sex, and body mass index [BMI] operate as moderators of this mediation relationship.Design: Moderated mediation model.Setting: An inpatient pulmonary rehabilitation center in Italy.Participants: All 153 patients involved in the screening of a randomized controlled clinical trial (ClinicalTrials.gov identifier: NCT01253941 were included in this study. All patients were Global initiative for chronic Obstructive Lung Disease (GOLD stages I–IV and were aged 70.1±9.1 years.Measurements: At run-in phase of the protocol, clinical and functional screening included BMI, fasting plasma levels of protein (IL-6, spirometry, and standardized 6-minute walking test, measured at the start of the respiratory rehabilitation program.Methods: The size of the indirect effect of the initial variable (FEV1 upon the outcome variable (6MWD through the intervening variable (IL-6 was computed and tested for statistical significance. Moderated mediation analyses were subsequently conducted with age, sex, and BMI.Results: FEV1 averaged 53.4%±21.2%, and 6MWD 66.4%±41.3% of predicted. Median protein IL-6 was 6.68 pg/mL (interquartile range: 5.96. A bootstrapped mediation test supported the predicted indirect

  7. La classe T "Economia" nella classificazione bibliografica Bliss Class T "Economics" in Bliss Bibliografic Classification

    Directory of Open Access Journals (Sweden)

    Elisabetta Viti

    2010-12-01

    Full Text Available Partendo da alcune considerazioni generali sul rapporto disciplina-fenomeno all'interno della Classificazione Bibliografica Bliss (2. ed., si offre una panoramica relativa all'architettura di uno specifico dominio disciplinare: l'economia. La difficoltà a sistematizzare questa disciplina come soggetto specifico e la rapida diffusione di acronimi e nuovi termini creati per abbreviazione o per combinazione di parole già esistenti, ha portato a una drastica revisione della struttura della tavola T, Economics & Management of economic enterprise, che è attualmente organizzata in categorie, faccette e sottofaccette, le quali, per formazione di classi composte, seguono un rigoroso ordine di citazione. Il sistema prevede un ordine lineare, una notazione per mantenere l'ordine di elencazione e un indice alfabetico di tutti i termini delle tavole. La BC2 è il solo esempio di architettura classificatoria analitico-sintetica completamente faccettata, aggiornata e coerentemente sviluppata, ma è poco usata al di fuori dell’Inghilterra ed è ancora priva di un'interfaccia web che possa rappresentare tutte le complesse relazioni semantiche del sistema. La sua struttura ha esercitato influenze sull'informatica, testimoniate dal progetto FATKS dell’University College London, che ha studiato l’impiego delle classificazioni analitico-sintetiche come base per l’indicizzazione delle risorse digitali. Sono inoltre in atto alcune sperimentazioni che mostrano le potenzialità di conversione di questa classificazione in formato thesaurus (in particolare della classe dedicata alla musica; ed è oggetto di studio lo sviluppo di un software di generare un thesaurus dagli stessi file di input, usati per la visualizzazione della classificazione e dell’indice alfabetico.L'autrice vuole porgere un sentito ringraziamento ad Alberto Cheti, Claudio Gnoli e Anna Lucarelli per la paziente lettura e i preziosi consigli.Starting from some general thoughts on the

  8. Genital impacts Genital impacts

    Directory of Open Access Journals (Sweden)

    Luiz Felipe G Soares

    2008-04-01

    Full Text Available I propose to analyze three images of genitalia from three different films that do not have sex as their central subject: (1 Lígia’s (Leona Cavalli’s vulva in Claudio Assis’s Amarelo Manga (Brazil, 2002, (2 Stoffer’s (Jens Albinus’s erect penis in Lars von Trier’s The Idiots (Denmark, 1998, and (3 transsexual Dil’s (Jaye Davidson’s penis in Neil Jordan’s The Crying Game (USA, 1992. All three images are explicit and surprising enough to provoke impact, both in diegetic and extra-diagetic spaces. intend to compare the three images and investigate the nature of their impacts, not directly in terms of morality, but in their relation with two theoretical assumptions: (1 the intense way in which, according to Linda Nicholson (1999, so many cultures insist in interpreting bodies and genitalia as still capable of defining gender characters, and (2 the notion of image, not as representation, but as image itself, as “what it is”, or as “the place of every transformation in the universe”, as suggested first by Bergson (2005, and then by Deleuze (1983-5, Rancière (2001 and Agamben (1995. The Deleuzean retard may indicate the way in which genitalia, as image, turn into enigma, in the very passage from nature to culture. The three shots give back to those clear images of genitalia the property they have always had: their character of central pieces in the game of such passage. The contrast between such simple and clear images and all those complex games corresponds to the nature of the impact I want to investigate. film; genitalia; narrative. I propose to analyze three images of genitalia from three different films that do not have sex as their central subject: (1 Lígia’s (Leona Cavalli’s vulva in Claudio Assis’s Amarelo Manga (Brazil, 2002, (2 Stoffer’s (Jens Albinus’s erect penis in Lars von Trier’s The Idiots (Denmark, 1998, and (3 transsexual Dil’s (Jaye Davidson’s penis in Neil Jordan’s The Crying Game (USA

  9. Motivado por cirujanos Motivated by Surgeons

    Directory of Open Access Journals (Sweden)

    Carlos Salazar-Vargas

    2010-12-01

    Full Text Available Comenzaba la década de los 60 y nuestro grupo nerviosamente iniciaba lecciones en los hospitales de San José. En aquellos años, el estudiante de medicina empezaba su contacto con pacientes, por lo menos 1 ó 2 años después de iniciada la carrera. El estudio del ser humano normal que ya habíamos concluido, continuaba con el del enfermo, y más adelante aprenderíamos el tratamiento. La enfermedad descrita en el libro, de pronto se convertía en un enfermo, y es a este quien hoy veíamos, cohibido pero inquisidor, en la cama de un hospital. Los profesores nos enseñaban a interrogar y a examinar a los pacientes, y cada gesto suyo, cada pregunta, cada maniobra, eran celosamente guardados en la memoria de los educandos. Con claridad percibíamos, aun a temprana edad, las diferencias entre los especialistas, y casi de manera involuntaria, cada quien iba tomando partido y escogía su futuro camino. Fue durante esos tempranos años, cuando mi vida se cruzó con la de 7 maravillosas personas y excelentes cirujanos, que marcaron para siempre mi destino y, sin quererlo ellos, me hicieron inclinarme por la cirugía. Dos eran serios y profundamente académicos: el Dr. Manuel Aguilar Bonilla y el Dr. Vesalio Guzmán Calleja; 3, decididos, incansables y muy hábiles: el Dr. Longino Soto Pacheco, el Dr. Claudio Orlich Carranza y el Dr. Carlos Prada Díaz, y 2, abordables, prácticos, joviales y amistosos: el Dr. Fernando Valverde Soley y el Dr. Randall Ferris Iglesias….During the early 60´s our class just started clinical lessons in different hospitals of San Jose. In those years the medical student became in contact with patients 1 or 2 years after initiating his or her career. The study of the normal human being continued with that of the diseased and later on we would learn how to treat our patients. The disease described in our textbooks, suddenly was a reality, a person lying in a hospital bed, shy but inquisitive. Our teachers taught us how to

  10. Vida de Carmen Caamaño Díaz : una voz del exilio interior

    Directory of Open Access Journals (Sweden)

    Mercedes Montero Caldera

    1999-01-01

    Full Text Available Este artículo recoge el testimonio oral de Carmen Caamaño Díaz (Madrid, 1911, quien a través de su memoria hace un recorrido autobiográfico en el que manifiesta la evolución de un compromiso ideológico que la convertiría en sujeto activo del exilio interior durante el régimen franquista. En su etapa universitaria, Carmen fue miembro de la junta Directiva de la FUE (Federación Española de Enseñantes y Secretaria General de la UFEH (Unión Federal de estudiantes Hispanoamericanos desde 1930 a 1931. Licenciada en Filosofía y Letras, trabajó en él Centro de estudios tiistohcos formando parte del equipo de investigación que dirigía Claudio Sáncfiez Albornoz. En 1937 ingresó en el P.C.E, desempeñando, entre otros cargos, el de Gobernadora Civil de Cuenca desde enero a marzo de 1939. Al finalizar la guerra, fue detenida y condenada a prisión. En 1941 trató de reorganizar en la clandestinidad el partido comunista en la provincia de Alicante, siendo nuevamente detenida y condenada a muerte, pena que le sería conmutada por la de cárcel. Depurada profesionalmente y bajo control policial durante varios años, su actividad de oposición al régimen de Franco la llevaría a cabo desde la Asociación de Mujeres Universitarias.This article includes the oral statement of Carmen Caamaño Díaz (Madrid, 1911, who covers her autobiography through her memory, expressing an ideogical compromise evolution through which she would become an active subjet of the inner exile throughout Franco's regime. While being a student at university, she was a member of the Board of Directors of the UFEH (Spanish Teachers Union and General Secretary of the UFEH (Latin American Student Union from 1930 to 1931. With a degree in Arts, she worked at the Centre of Historie Studies taking part within the investigation team conducted by Claudio Sánchez Albornoz. In 1937 she joined the Spanish Communist Party, performing the charge, amongst others, of Civil Governor

  11. Genetic aspects of athletic performance: the African runners phenomenon

    Directory of Open Access Journals (Sweden)

    Vancini RL

    2014-05-01

    Full Text Available Rodrigo Luiz Vancini,1 João Bosco Pesquero,2 Rafael Júlio Fachina,3,4 Marília dos Santos Andrade,1 João Paulo Borin,3 Paulo César Montagner,3 Claudio Andre Barbosa de Lira51Centro de Educação Física e Desportos, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil; 2Departamento de Biofísica, Universidade Federal de São Paulo, São Paulo, Brazil; 3Departamento de Ciência do Esporte, Faculdade de Educação Física, Universidade Estadual de Campinas, Campinas, Brazil; 4Confederação Brasileira de Basquetebol, Rio de Janeiro, Brazil; 5Setor de Fisiologia Humana e do Exercício, Faculdade de Educação Física, Universidade Federal de Goiás, Goiânia, BrazilAbstract: The current dominance of African runners in long-distance running is an intriguing phenomenon that highlights the close relationship between genetics and physical performance. Many factors in the interesting interaction between genotype and phenotype (eg, high cardiorespiratory fitness, higher hemoglobin concentration, good metabolic efficiency, muscle fiber composition, enzyme profile, diet, altitude training, and psychological aspects have been proposed in the attempt to explain the extraordinary success of these runners. Increasing evidence shows that genetics may be a determining factor in physical and athletic performance. But, could this also be true for African long-distance runners? Based on this question, this brief review proposed the role of genetic factors (mitochondrial deoxyribonucleic acid, the Y chromosome, and the angiotensin-converting enzyme and the alpha-actinin-3 genes in the amazing athletic performance observed in African runners, especially the Kenyans and Ethiopians, despite their environmental constraints.Keywords: genes, genotype, physical exercise, endurance runners

  12. Descriptive epidemiology of injuries in a Brazilian premier league soccer team

    Directory of Open Access Journals (Sweden)

    Fachina RJ

    2013-06-01

    Full Text Available Rafael Júlio de Freitas Guina Fachina,1,2 Marília dos Santos Andrade,3 Fernando Roberto Silva,4 Silas Waszczuk-Junior,4 Paulo César Montagner,1 João Paulo Borin,1 Claudio Andre Barbosa de Lira5 1Departamento de Ciência do Esporte, Faculdade de Educação Física, Universidade Estadual de Campinas (UNICAMP, Campinas, Brazil; 2Confederação Brasileira de Basketball (CBB, Rio de Janeiro, Brazil; 3Departamento de Fisiologia, Universidade Federal de São Paulo, São Paulo, Brazil; 4Grêmio Barueri Futebol LTDA, Barueri, Brazil; 5Setor de Fisiologia Humana e do Exercício, Universidade Federal de Goiás, Câmpus Jataí, Jataí, Brazil Abstract: Soccer, which has a large number of participants, has a high injury incidence that causes both financial and time burdens. Therefore, knowledge about the epidemiology of soccer injuries could allow sports-medicine professionals, such as physicians and physiotherapists, to direct their work in specific preventive programs. Thus, our aim was to conduct an epidemiological survey of injuries sustained by professional soccer players from the same team who participated in the Brazilian championship premier league in 2009. To this end, we evaluated retrospectively player medical records from the team, which included name, date of birth, position, date of injury, mechanism of injury, and type of injury. In the period of study, 95 injuries were recorded: 42 (44.2% were recorded during matches, and 53 (55.8% during the training period. Injuries occurred more frequently in midfielders and strikers. All injuries happened in the lower limb, most of the injuries were muscular, and most occurred as the result of collisions with other athletes. In summary, this study demonstrates that there is a need for greater safety awareness in the training environment. Keywords: injuries, epidemiology, soccer players

  13. Cultura y estética popular: lo híbrido, el gusto y la experiencia

    Directory of Open Access Journals (Sweden)

    Élver Chaparro

    2013-09-01

    Full Text Available Este artículo, enmarcado en el proyecto “Cultura y estética popular en Boyacá” (del grupo de investigación XISQUA de la carrera de diseño gráfico de la Universidad de Boyacá, aborda, en primera instancia, algunas nociones de cultura a partir de la relación pensamiento-lenguaje- comunicación, esbozada en Eco y Díaz de Rada, quienes ofrecen elementos conceptuales para abordar la cultura en el ámbito de la comunicación y las prácticas sociales. Posteriormente se hace un rastreo histórico de la categoría cultura popular, tomando como marco de referencia los trabajos de M. Bajtin y Peter Burke, quienes establecen una correspondencia entre la cultura popular y la relación tensionante entre alta y baja cultura. En el marco de los procesos de modernización e hibridación de la cultura popular se revisa el trabajo del profesor Néstor García Canclini junto con algunas características de la experiencia estética y de las nociones de gusto que particularizan lo popular en los trabajos de Pierre Bourdieu, Claudio Malo y Sergio Martínez Luna. Por último, se reflexiona, a partir de los postulados de Martín-Barbero, sobre cómo los procesos mencionados anteriormente están mediados en la actualidad por la globalización, con las consecuentes influencias sobre los procesos de identidad local.

  14. Class T "Economics" in Bliss Bibliografic Classification

    Directory of Open Access Journals (Sweden)

    Elisabetta Viti

    2010-12-01

    Full Text Available Starting from some general thoughts on the relationship discipline-phenomenon within the Bliss bibliographic classification (2. ed., the article offers an overview of the architecture of a specific field: economics. The difficulties in systematizing the discipline, and the quick diffusion of acronyms and new definitions - created by abbreviation or combination of existing words - lead to a full structural revision of the T entry, Economics & Management of economic enterprise, that at the moment is organized into categories, facets, and subfacets, offering a strict citation order. The system has a linear order, a notation to maintain the listing order, and an alphabetic list of the terms. BC2 is the only example of a classifying analytic-concise architecture fully faceted, updated and coherently developed, even though it is few used outside the United Kingdom, and it still lacks a web interface representing the semantic relations of the system. The influence of BC2 structure on computer science is shown by the FATKS project of the University College London, a project that studies the use of analytic-concise classification systems as the basis for digital resources indexing. Moreover, some ongoing experimentations are demonstrating the potential of this classification to be converted into a thesaurus; in addition, a software for supporting the semi-automatic generation of a thesaurus starting from the input files used for producing the classification and the alphabetic list, is under consideration.The author would thank Alberto Cheti, Claudio Gnoli and Anna Lucarelli for the precise reading and valued suggestions.

  15. An evidence-based review on urate-lowering treatments: implications for optimal treatment of chronic hyperuricemia

    Directory of Open Access Journals (Sweden)

    Bove M

    2017-02-01

    Full Text Available Marilisa Bove, Arrigo Francesco Giuseppe Cicero, Maddalena Veronesi, Claudio Borghi Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy Abstract: Several studies suggest that chronic hyperuricemia, the main precursor of gout, is involved in the pathogenesis of different systemic disorders that affect cardiovascular and renal systems, such as hypertension, obesity, hypercholesterolemia, atherosclerosis, metabolic syndrome, chronic heart failure, and chronic kidney disease. Recent epidemiological evidence has shown an increasing trend in the prevalence of hyperuricemia and gout in the Western world: a number of population-based studies estimate a prevalence of up to 21% for hyperuricemia and 1%–4% for gout. As such, early detection and careful management of this pathological condition is required, starting from lifestyle changes (mainly based on a diet low in red meat, sugars, and alcoholic beverages, with increased intake of vegetables, water, and vitamin C sources, adding specific drugs to lead serum uric acid (SUA levels under the target value of 7 mg/dL. In particular, nonselective and selective XO inhibitors (allopurinol, oxypurinol, febuxostat reduce SUA levels and the overproduction of reactive oxygen species, mainly related to XO overactivity that often causes inflammatory damage to the vascular endothelium. The effect of lowering SUA levels via XO inhibition includes an attenuation of oxidative stress and related endothelial dysfunction that largely contribute to the pathophysiology of metabolic syndrome and cardiovascular diseases. Therefore, the inhibition of XO overactivation seems to be an excellent therapeutic option to limit the harmful effects of excess UA and reactive oxygen species. In conclusion, rapid diagnosis and correct therapy for hyperuricemia may also improve the prevention and/or treatment of serious and multifactorial diseases. The available evidence supports the importance of

  16. Comercio e intercambio de cerámicas finas en la Bética (ss. I-II d. C.: reflexiones generales en torno a la economía altoimperial al hilo del análisis del ejemplo isturgitano

    Directory of Open Access Journals (Sweden)

    Pablo RUIZ MONTES

    2013-06-01

    Full Text Available El análisis de un caso concreto, el de la comercialización de la producción de cerámicas finas de los talleres alfareros de Los Villares de Andújar (Jaén, antigua Isturgi, ofrece la oportunidad para reflexionar sobre diversos aspectos relativos al intercambio y circulación de este tipo de bienes coincidiendo con los años de mayor bonanza económica y social en la Bética; el análisis de la naturaleza de la economía romana, de las formas y alcance que adquiere el comercio en cuestión (distribución local-regional y a larga distancia y su caracterización esencial, así como otros elementos colaterales al fenómeno (valor, gusto, consumidores..., han centrado nuestra atención. Todo ello permite dibujar una situación de excepcional dinamismo económico del que la producción y comercio de vajillas cerámicas locales, en especial la sigillata, es parte, pero también consecuencia. El proceso, intensificado desde Claudio I gracias al desarrollo de la red de comunicaciones y los transportes, la mayor demanda de bienes y un moderado crecimiento demográfico, propicia la aparición de nuevos estándares en la producción de cerámicas finas locales béticas, hasta entonces dominada aún por las tradiciones autóctonas y la desestructurada producción de cerámicas tipo Peñaflor.

  17. Moradas de la razón sensible

    Directory of Open Access Journals (Sweden)

    María Eugenia Boito

    2012-03-01

    Full Text Available “Jirones de piel, ágape insumiso” establece relaciones entre la reflexión epistemológica, la estética y la normatividad en catorce apartados que –como jirones– pueden interpretarse como “pequeñas porciones de un todo”; fragmentos de telas (tramas discursivas que recorren y se detienen en la interrogación de la compleja madeja que reúne los tópicos antes referidos. Pero “jirón” tiene otro significado en el campo de la heráldica que en mi lectura, está asociada a las figuras que produce el texto: “jirón” es una forma triangular que desde el borde del escudo, llega hasta el centro o corazón de este. Claudio Martyniuk afirma “no ensancha escribir, no ensancha leer, apenas salva del extravío y de la tristeza vacías”. Sin embargo los jirones de su escritura ensayística (el ensayo como género que pretende “un despliegue que tense los entumecidos polos de la sensibilidad y el pensamiento” se orientan a proteger como escudo –pero a la vez interrogar– lo que se encuentra el corazón de los recorridos de la obra: los ejercicios de violencia cotidiana sobre nuestra piel. Por esto además de salvar del extravío y de la tristeza, la escritura de Martyniuk señala –y asila, da regazo– a la piel como instancia de expresión de nuestra sensibilidad.

  18. Bismuth oxide aqueous colloidal nanoparticles inhibit Candida albicans growth and biofilm formation

    Directory of Open Access Journals (Sweden)

    Hernandez-Delgadillo R

    2013-04-01

    Full Text Available Rene Hernandez-Delgadillo,1 Donaji Velasco-Arias,3 Juan Jose Martinez-Sanmiguel,2 David Diaz,3 Inti Zumeta-Dube,3 Katiushka Arevalo-Niño,1 Claudio Cabral-Romero2 1Facultad de Ciencias Biológicas, Instituto de Biotecnologia, Universidad Autonoma de Nuevo Leon, UANL, Monterrey, Mexico; 2Facultad de Odontología, Universidad Autonoma de Nuevo Leon, UANL, Monterrey, México; 3Facultad de Quimica, Universidad Nacional Autonoma de Mexico, UNAM, Distrito Federal, México Abstract: Multiresistance among microorganisms to common antimicrobials has become one of the most significant concerns in modern medicine. Nanomaterials are a new alternative to successfully treat the multiresistant microorganisms. Nanostructured materials are used in many fields, including biological sciences and medicine. Recently, it was demonstrated that the bactericidal activity of zero-valent bismuth colloidal nanoparticles inhibited the growth of Streptococcus mutans; however the antimycotic potential of bismuth nanostructured derivatives has not yet been studied. The main objective of this investigation was to analyze the fungicidal activity of bismuth oxide nanoparticles against Candida albicans, and their antibiofilm capabilities. Our results showed that aqueous colloidal bismuth oxide nanoparticles displayed antimicrobial activity against C. albicans growth (reducing colony size by 85% and a complete inhibition of biofilm formation. These results are better than those obtained with chlorhexidine, nystatin, and terbinafine, the most effective oral antiseptic and commercial antifungal agents. In this work, we also compared the antimycotic activities of bulk bismuth oxide and bismuth nitrate, the precursor metallic salt. These results suggest that bismuth oxide colloidal nanoparticles could be a very interesting candidate as a fungicidal agent to be incorporated into an oral antiseptic. Additionally, we determined the minimum inhibitory concentration for the synthesized

  19. Chronic fluoxetine treatment increases daytime melatonin synthesis in the rodent

    Directory of Open Access Journals (Sweden)

    Gillian W Reierson

    2009-09-01

    Full Text Available Gillian W Reierson, Claudio A Mastronardi, Julio Licinio, Ma-Li WongCenter on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USAAbstract: Circadian rhythm disturbances can occur as part of the clinical symptoms of major depressive disorder and have been found to resolve with antidepressant therapy. The pineal gland is relevant to circadian rhythms as it secretes the hormone melatonin following activation of the cyclic adenosine monophosphate (cAMP signaling cascade and of arylalkylamine N-acetyltransferase (AA-NAT, the rate-limiting enzyme for its synthesis. Cyclic AMP is synthesized by adenylate cyclases (AC and degraded by phosphodiesterases (PDEs. Little is known about the contribution of the PDE system to antidepressant-induced alterations in pineal cAMP signaling and melatonin synthesis. In the present study we used enzyme immunoassay to measure plasma melatonin levels and pineal cAMP levels and as well as quantitative real-time polymerase chain reaction to measure pineal expression of PDE, AC, and AA-NAT genes in rats chronically treated with the prototypic antidepressant fluoxetine. We found elevated melatonin synthesis with increased pineal AA-NAT gene expression and daytime plasma melatonin levels and downregulated cAMP signaling with increased PDE and unchanged AC pineal gene expression, and decreased content of pineal cAMP. We conclude that chronic fluoxetine treatment increases daytime plasma melatonin and pineal AA-NAT gene expression despite downregulated pineal cAMP signaling in the rodent.Keywords: antidepressant, melatonin, pineal, nucleotides, cyclic, phosphodiesterase, rat

  20. Profile of evolocumab and its potential in the treatment of hyperlipidemia

    Directory of Open Access Journals (Sweden)

    Cicero AF

    2015-06-01

    Full Text Available Arrigo FG Cicero, Alessandro Colletti, Claudio Borghi Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy Abstract: Despite the proven efficacy of statins, they often fail to achieve low-density lipoprotein (LDL cholesterol goals, especially in high-risk patients. Moreover, a large number of subjects cannot tolerate statins or full doses of these drugs, in particular patients with familial hypercholesterolemia. Thus, there is a need for additional effective LDL cholesterol-reducing agents. Evolocumab (AMG145 is a monoclonal antibody inhibiting proprotein convertase subtilisin/kexin type 9 that binds to the liver LDL receptor and prevents it from normal recycling by targeting it for degradation. Phase I, II, and III trials revealed that, on subcutaneous injection, either alone or in combination with statins, evolocumab is able to reduce high LDL cholesterol levels from 54% to 80%, apolipoprotein B100 from 31% to 61%, and lipoprotein(a from 12% to 36%, in a dose-dependent manner. The incidence of side effects seems to be low and mainly limited to nasopharyngitis, injection site pain, arthralgia, and back pain. Evolocumab is an innovative powerful lipid-lowering drug, additive to statins and/or ezetimibe, with a large therapeutic range associated with a low rate of mild adverse events. If the available data are confirmed in long-term trials with strong outcome measures, evolocumab will become an essential tool in the treatment of a large number of high-risk patients, such as those affected by familial hypercholesterolemia, those who are unable to tolerate an efficacious statin dosage, and those at very high cardiovascular risk and unable to achieve their target LDL cholesterol levels with currently available lipid-lowering therapies. Keywords: hypercholesterolemia, lipid-lowering drugs, proprotein convertase subtilisin/kexin type 9, AMG145

  1. Ultrasound-mediated oncolytic virus delivery and uptake for increased therapeutic efficacy: state of art

    Directory of Open Access Journals (Sweden)

    Nande R

    2015-11-01

    Full Text Available Rounak Nande,1 Candace M Howard,2 Pier Paolo Claudio,3,4 1Department of Biochemistry and Microbiology, Marshall University School of Medicine, Huntington, WV, 2Department of Radiology, University of Mississippi Medical Center, Jackson, MS, 3Department of BioMolecular Sciences and National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS, 4Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS, USA Abstract: The field of ultrasound (US has changed significantly from medical imaging and diagnosis to treatment strategies. US contrast agents or microbubbles (MB are currently being used as potential carriers for chemodrugs, small molecules, nucleic acids, small interfering ribonucleic acid, proteins, adenoviruses, and oncolytic viruses. Oncolytic viruses can selectively replicate within and destroy a cancer cell, thus making them a powerful therapeutic in treating late-stage or metastatic cancer. These viruses have been shown to have robust activity in clinical trials when injected directly into tumor nodules. However limitations in oncolytic virus’ effectiveness and its delivery approach have warranted exploration of ultrasound-mediated delivery. Gene therapy bearing adenoviruses or oncolytic viruses can be coupled with MBs and injected intravenously. Following application of US energy to the target region, the MBs cavitate, and the resulting shock wave enhances drug, gene, or adenovirus uptake. Though the underlying mechanism is yet to be fully understood, there is evidence to suggest that mechanical pore formation of cellular membranes allows for the temporary uptake of drugs. This delivery method circumvents the limitations due to stimulation of the immune system that prevented intravenous administration of viruses. This review provides insight into this intriguing new frontier on the delivery of oncolytic viruses to tumor sites.Keywords: microbubbles, ultrasound

  2. Mithramycin encapsulated in polymeric micelles by microfluidic technology as novel therapeutic protocol for beta-thalassemia

    Directory of Open Access Journals (Sweden)

    Capretto L

    2012-01-01

    Full Text Available Lorenzo Capretto1, Stefania Mazzitelli2, Eleonora Brognara2, Ilaria Lampronti2, Dario Carugo1, Martyn Hill1, Xunli Zhang1, Roberto Gambari2, Claudio Nastruzzi31Engineering Sciences, University of Southampton, Southampton, UK; 2Department of Biochemistry and Molecular Biology, 3Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, ItalyAbstract: This report shows that the DNA-binding drug, mithramycin, can be efficiently encapsulated in polymeric micelles (PM-MTH, based on Pluronic® block copolymers, by a new microfluidic approach. The effect of different production parameters has been investigated for their effect on PM-MTH characteristics. The compared analysis of PM-MTH produced by microfluidic and conventional bulk mixing procedures revealed that microfluidics provides a useful platform for the production of PM-MTH with improved controllability, reproducibility, smaller size, and polydispersity. Finally, an investigation of the effects of PM-MTH, produced by microfluidic and conventional bulk mixing procedures, on the erythroid differentiation of both human erythroleukemia and human erythroid precursor cells is reported. It is demonstrated that PM-MTH exhibited a slightly lower toxicity and more pronounced differentiative activity when compared to the free drug. In addition, PM-MTH were able to upregulate preferentially γ-globin messenger ribonucleic acid production and to increase fetal hemoglobin (HbF accumulation, the percentage of HbF-containing cells, and their HbF content without stimulating α-globin gene expression, which is responsible for the clinical symptoms of ß-thalassemia. These results represent an important first step toward a potential clinical application, since an increase in HbF could alleviate the symptoms underlying ß-thalassemia and sickle cell anemia. In conclusion, this report suggests that PM-MTH produced by microfluidic approach warrants further evaluation as a potential therapeutic protocol

  3. Zerovalent bismuth nanoparticles inhibit Streptococcus mutans growth and formation of biofilm

    Directory of Open Access Journals (Sweden)

    Hernandez-Delgadillo R

    2012-04-01

    Full Text Available Rene Hernandez-Delgadillo1, Donaji Velasco-Arias2, David Diaz2, Katiushka Arevalo-Niño1, Marianela Garza-Enriquez1, Myriam A De la Garza-Ramos1, Claudio Cabral-Romero11Instituto de Biotecnologia, Centro de Investigacion y Desarrollo en Ciencias de la Salud, CIDICS, Facultad de Odontologia, Universidad Autonoma de Nuevo Leon, UANL, Monterrey, Nuevo Leon, 2Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Distrito Federal, MexicoBackground and methods: Despite continuous efforts, the increasing prevalence of resistance among pathogenic bacteria to common antibiotics has become one of the most significant concerns in modern medicine. Nanostructured materials are used in many fields, including biological sciences and medicine. While some bismuth derivatives has been used in medicine to treat vomiting, nausea, diarrhea, and stomach pain, the biocidal activity of zerovalent bismuth nanoparticles has not yet been studied. The objective of this investigation was to analyze the antimicrobial activity of bismuth nanoparticles against oral bacteria and their antibiofilm capabilities.Results: Our results showed that stable colloidal bismuth nanoparticles had 69% antimicrobial activity against Streptococcus mutans growth and achieved complete inhibition of biofilm formation. These results are similar to those obtained with chlorhexidine, the most commonly used oral antiseptic agent. The minimal inhibitory concentration of bismuth nanoparticles that interfered with S. mutans growth was 0.5 mM.Conclusion: These results suggest that zerovalent bismuth nanoparticles could be an interesting antimicrobial agent to be incorporated into an oral antiseptic preparation.Keywords: zerovalent bismuth nanoparticles, antimicrobial agent, biofilm, Streptococcus mutans

  4. Problem-solving strategies in psychiatry: differences between experts and novices in diagnostic accuracy and reasoning

    Directory of Open Access Journals (Sweden)

    Gabriel A

    2013-01-01

    Full Text Available Adel Gabriel,1,2 Claudio Violato21Departments of Psychiatry, University of Calgary, Calgary; 2Medical Education, Community Health Sciences, University of Calgary Calgary, CanadaBackground: The purpose of this study was to examine and compare diagnostic success and its relationship with the diagnostic reasoning process between novices and experts in psychiatry.Methods: Nine volunteers, comprising five expert psychiatrists and four clinical clerks, completed a think-aloud protocol while attempting to make a DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnosis of a selected case with both Axis I and Axis III diagnoses.Results: Expert psychiatrists made significantly more successful diagnoses for both the primary psychiatric and medical diagnoses than clinical clerks. Expert psychiatrists also gave fewer differential options. Analyzing the think-aloud protocols, expert psychiatrists were much more organized, made fewer mistakes, and utilized significantly less time to access their knowledge than clinical clerks. Both novices and experts seemed to use the hypothetic-deductive and scheme-inductive approaches to diagnosis. However, experts utilized hypothetic-deductive approaches significantly more often than novices.Conclusion: The hypothetic-deductive diagnostic strategy was utilized more than the scheme-inductive approach by both expert psychiatrists and clinical clerks. However, a specific relationship between diagnostic reasoning and diagnostic success could not be identified in this small pilot study. The author recommends a larger study that would include a detailed analysis of the think-aloud protocols.Keywords: diagnostic reasoning, knowledge structure, psychiatric diagnosis, hypothetic-deductive, scheme-inductive

  5. Cystoid macular edema after cataract surgery in a patient with previous severe iritis following argon laser peripheral iridoplasty

    Directory of Open Access Journals (Sweden)

    Bagnis A

    2011-04-01

    Full Text Available Alessandro Bagnis1, Sergio Claudio Saccà2, Michele Iester1, Carlo Enrico Traverso11Centro di Ricerca Clinica e Laboratorio per il Glaucoma e la Cornea, Clinica Oculistica Di NOG, University of Genova, 2Division of Ophthalmology, St. Martino Hospital, Genova, ItalyAbstract: This report describes a patient who had exaggerated responses to different inflammatory stimuli represented by laser and incisional surgery, respectively. These separate episodes should have a common link represented by a genetic predisposition to abnormal release of proinflammatory mediators within the eye. This 51-year old Hispanic woman showed a narrow iridocorneal angle with plateau iris configuration. Nd-YAG laser peripheral iridotomy was successfully performed to both eyes. No substantial changes in the iridotrabecular angle occurred despite patent iridotomies, thus confirming the diagnosis of plateau iris configuration. Argon laser iridoplasty was then performed to the right eye, while the left eye was scheduled for a later session. A severe inflammatory reaction within the anterior chamber developed after tapering of a one-week course of steroid therapy. Phacoemulsification of the lens was performed some months later when no signs of inflammation were detectable; no intraoperative complications occurred during surgery and an intraocular lens was placed. Cystoid macular edema developed four weeks after surgery despite no apparent risk factors, and resolved completely after anti-inflammatory medical therapy. Based on this case report, the unusual occurrence of severe iritis after laser treatment should be regarded as a risk factor for any other incisional or nonincisional procedures because it might indicate that the patient's ocular tissues are prone to release of abnormally elevated proinflammatory mediators. Although further studies are needed to confirm this predisposition, prophylactic adjunctive topical nonsteroidal anti-inflammatory drug administration after

  6. New advances in the treatment of generalized lipodystrophy: role of metreleptin

    Directory of Open Access Journals (Sweden)

    Rodriguez AJ

    2015-09-01

    Full Text Available Alexander J Rodriguez,1 Claudio A Mastronardi,2 Gilberto J Paz-Filho2 1Department of Medicine, Monash Medical Centre, Clayton, VIC, 2Department of Genome Sciences, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, AustraliaAbstract: Recombinant methionyl human leptin or metreleptin is a synthetic leptin analog that has been trialed in patients with leptin-deficient conditions, such as leptin deficiency due to mutations in the leptin gene, hypothalamic amenorrhea, and lipodystrophy syndromes. These syndromes are characterized by partial or complete absence of adipose tissue and hormones derived from adipose tissue, most importantly leptin. Patients deficient in leptin exhibit a number of severe metabolic abnormalities such as hyperglycemia, hypertriglyceridemia, and hepatic steatosis, which can progress to diabetes mellitus, acute pancreatitis, and hepatic cirrhosis, respectively. For the management of these abnormalities, multiple therapies are usually required, and advanced stages may be progressively difficult to treat. Following many successful trials, the US Food and Drug Administration approved metreleptin for the treatment of non-HIV-related forms of generalized lipodystrophy. Leptin replacement therapy with metreleptin has, in many cases, reversed these metabolic complications, with improvements in glucose-insulin-lipid homeostasis, and regression of fatty liver disease. Besides being effective, a daily subcutaneous administration of metreleptin is generally safe, but the causal association between metreleptin and immune complications (such as lymphoma is still unclear. Moreover, further investigation is needed to elucidate mechanisms by which metreleptin leads to the development of anti-leptin antibodies. Herein, we review clinical aspects of generalized lipodystrophy and the pharmacological profile of metreleptin. Further, we examine studies that assessed the safety and efficacy of

  7. Clinical experience and critical evaluation of the role of everolimus in advanced renal cell carcinoma

    Directory of Open Access Journals (Sweden)

    Sun M

    2011-04-01

    Full Text Available Maxine Sun1, Firas Abdollah2, Jan Schmitges1, Claudio Jeldres1, Shahrokh F Shariat3, Paul Perrotte4, Pierre I Karakiewicz1,4 1Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Canada; 2Department of Urology, Vita Salute San Raffaele University, Milan, Italy; 3Department of Urology, Weill Medical College of Cornell University, New York, NY, USA; 4Department of Urology, University of Montreal Health Center, Montreal, CanadaAbstract: The efficacy of sequential everolimus, an orally administered inhibitor of mammalian target of rapamycin (mTOR, was proven in a placebo-controlled phase III study, where median progression-free survival was 4.9 vs 1.9 months for placebo (hazard ratio: 0.33, P < 0.001. Placebo crossovers (80% contaminated overall survival data. Adverse event discontinuation rate was of only 10% and health-adjusted quality-of-life was sustained. These data represent the first placebo-controlled evidence of efficacy for a seque ntially used targeted agent. Everolimus resulted in the strongest hazard ratio ever recorded for progression-free survival, despite it being tested in a population with the most aggressive natural history ever recorded in all available phase III metastatic renal cell carcinoma trials. Everolimus use after exclusively one prior antivascular endothelial growth factor f ailure resulted in an even longer progression-free survival time (5.4 months than in the entire population (4.9 months. These benefits should also be considered in the light of sustained and unimpaired health-related quality of life. Use in first line other than second or subsequent lines remains to be validated.Keywords: everolimus, metastatic renal cell carcinoma, targeted therapy, sequential therapy, mTOR

  8. ETNOGRAFIA - As paneleiras de Goiabeiras e a arte de fazer panela de barro: Ensaio etnográfico sobre a cultura do barro

    Directory of Open Access Journals (Sweden)

    Braz Campos Nicole

    2012-07-01

    Full Text Available Reconhecida pelo Instituto do Patrimônio Histórico e Artístico Nacional (IPHAN, 2006 como um Patrimônio Cultural Imaterial do Brasil, a “arte de fazer panela de barro” representa uma das principais referências culturais do Espírito Santo. Objeto de pesquisas e artigos científicos (Perota, 1997; Dias, 2006; Rodrigues, 2012; entre outros, as Paneleiras de Goiabeiras Velha destacam-se pelo modo sui generis de produção das peças cerâmicas, assegurando para si a autenticidade da panela de barro capixaba. Tento em vista sua relevância, este ensaio descreverá o processo de confecção das panelas de barro e os significados que perpassam esse processo. Ademais, analisará a interconexão cultural entre a cultura do barro e a lógica capitalista, buscando entender sua dinâmica cultural. O presente trabalho resulta de pesquisas realizadas entre 2009 e 2011, com as 32 Paneleiras associadas e que trabalham no galpão3 da Associação das Paneleiras de Goiabeiras Velha (APG, Vitória, Espírito Santo. A partir de 2011, as pesquisas foram revisadas e organizadas no Núcleo de Estudos e Pesquisas Indiciárias da Universidade Federal do Espírito Santo (NEI/UFES, sob a orientação do professor Claudio Marcio Coelho. Trata-se de um estudo qualitativo, tendo como instrumentos de coleta de dados: entrevistas, histórias de vida, questionários semiestruturados, pesquisa documental, pesquisa bibliográfica e observação direta.Palavras-Chave: paneleiras; Goiabeiras Velha; panela de barro; interpretativismo cultural.

  9. Agronomic traits and deoxynivalenol contamination of two tetraploid wheat species (Triticum turgidum spp. durum, Triticum turgidum spp. turanicum grown strictly under low input conditions

    Directory of Open Access Journals (Sweden)

    Giovanni Dinelli

    2014-09-01

    Full Text Available An evaluation of the agronomic performance of two tetraploid wheat varieties (Triticum turgidum spp. durum, Claudio; Triticum turgidum spp. turanicum, Kamut® grown strictly under low input conditions was carried out over three consecutive cropping years. The study reported grain yield values ranging from 1.8 to 2.6 t ha-1. Productivity showed to be primarily affected by environmental conditions, while no differences were observed between the two genotypes. The study of the yield components highlighted that the durum wheat variety had a higher plant density than Kamut®, but this discrepancy was offset by a greater number of kernels per spike and the kernel weight of khorasan wheat. The investigated wheat genotypes were also analysed to assess the mycotoxin (DON levels of wholegrain semolina and the efficiency of cleaning treatments to reduce contamination. Results showed that both wheat varieties had a good hygienic and sanitary quality with a DON content ranging from 0.35 to 1.31 mg kg-1, which was lower than the maximum acceptable level set by the European regulation at 1.75 mg kg-1. In addition, our research work investigated the effects of premilling cleaning procedures, such as water washing and brushing, on mycotoxin levels, which yielded interesting results in terms of decontamination efficiency. These methods were particularly efficient with Kamut® semolina (46-93% DON reduction, suggesting that mycotoxins accumulate in this variety at more superficial levels than in the durum wheat variety. On the whole, our study provided additional knowledge on the traits to be further improved to respond to low input requirements and to enhance the potential adaptability of wheat genotypes to organic agriculture. Our results emphasized the need to develop wheat varieties that can provide adequate performance without high levels of nitrogen inputs by selecting specific traits, such as kernel weight, spike length and kernel/spike. This may help

  10. Motivado por cirujanos

    Directory of Open Access Journals (Sweden)

    Carlos Salazar-Vargas

    2010-12-01

    Full Text Available Comenzaba la década de los 60 y nuestro grupo nerviosamente iniciaba lecciones en los hospitales de San José. En aquellos años, el estudiante de medicina empezaba su contacto con pacientes, por lo menos 1 ó 2 años después de iniciada la carrera. El estudio del ser humano normal que ya habíamos concluido, continuaba con el del enfermo, y más adelante aprenderíamos el tratamiento. La enfermedad descrita en el libro, de pronto se convertía en un enfermo, y es a este quien hoy veíamos, cohibido pero inquisidor, en la cama de un hospital. Los profesores nos enseñaban a interrogar y a examinar a los pacientes, y cada gesto suyo, cada pregunta, cada maniobra, eran celosamente guardados en la memoria de los educandos. Con claridad percibíamos, aun a temprana edad, las diferencias entre los especialistas, y casi de manera involuntaria, cada quien iba tomando partido y escogía su futuro camino. Fue durante esos tempranos años, cuando mi vida se cruzó con la de 7 maravillosas personas y excelentes cirujanos, que marcaron para siempre mi destino y, sin quererlo ellos, me hicieron inclinarme por la cirugía. Dos eran serios y profundamente académicos: el Dr. Manuel Aguilar Bonilla y el Dr. Vesalio Guzmán Calleja; 3, decididos, incansables y muy hábiles: el Dr. Longino Soto Pacheco, el Dr. Claudio Orlich Carranza y el Dr. Carlos Prada Díaz, y 2, abordables, prácticos, joviales y amistosos: el Dr. Fernando Valverde Soley y el Dr. Randall Ferris Iglesias….

  11. A study of periodic and aperiodic ferromagnetic antidot lattices

    Science.gov (United States)

    Bhat, Vinayak S.

    This thesis reports our study of the effect of domain wall pinning by ferromagnetic (FM) metamaterials [1] in the form of periodic antidot lattices (ADL) on spin wave spectra in the reversible regime. This study was then extended to artificial quasicrystals in the form of Penrose P2 tilings (P2T). Our DC magnetization study of these metamaterials showed reproducible and temperature dependent knee anomalies in the hysteretic regime that are due to the isolated switching of the FM segments. Our dumbbell model analysis [2] of simulated magnetization maps indicates that FM switching in P2T is nonstochastic . We have also acquired the first direct, two-dimensional images of the magnetization of Permalloy films patterned into P2T using scanning electron microscopy with polarization analysis (SEMPA). Our SEMPA images demonstrate P2T behave as geometrically frustrated networks of narrow ferromagnetic film segments having near-uniform, bipolar (Ising-like) magnetization, similar to artificial spin ices (ASI). We find the unique aperiodic translational symmetry and diverse vertex coordination of multiply-connected P2T induce a more complex spin-ice behavior driven by exchange interactions in vertex domain walls, which differs markedly from the behavior of disconnected ASI governed only by dipolar interactions. Keywords: Ferromagnetic Antidot Lattices, Metamaterials, Ferromagnetic Resonance, Artificial Quasicrystal, Artificial Spin Ice. [1] VV Kruglyak et al. "Magnonic metamaterials". In: Metamaterial, edited by X.-Y. Jiang (InTech, 2012) (2012). [2] Claudio Castelnovo, Roderich Moessner, and Shivaji L Sondhi. "Magnetic monopoles in spin ice". In: Nature 451.7174 (2008), pp. 42--45.

  12. High-throughput SNP discovery and genotyping in durum wheat (Triticum durum Desf.).

    Science.gov (United States)

    Trebbi, Daniele; Maccaferri, Marco; de Heer, Peter; Sørensen, Anker; Giuliani, Silvia; Salvi, Silvio; Sanguineti, Maria Corinna; Massi, Andrea; van der Vossen, Edwin Andries Gerard; Tuberosa, Roberto

    2011-08-01

    We describe the application of complexity reduction of polymorphic sequences (CRoPS(®)) technology for the discovery of SNP markers in tetraploid durum wheat (Triticum durum Desf.). A next-generation sequencing experiment was carried out on reduced representation libraries obtained from four durum cultivars. SNP validation and minor allele frequency (MAF) estimate were carried out on a panel of 12 cultivars, and the feasibility of genotyping these SNPs in segregating populations was tested using the Illumina Golden Gate (GG) technology. A total of 2,659 SNPs were identified on 1,206 consensus sequences. Among the 768 SNPs that were chosen irrespective of their genomic repetitiveness level and assayed on the Illumina BeadExpress genotyping system, 275 (35.8%) SNPs matched the expected genotypes observed in the SNP discovery phase. MAF data indicated that the overall SNP informativeness was high: a total of 196 (71.3%) SNPs had MAF >0.2, of which 76 (27.6%) showed MAF >0.4. Of these SNPs, 157 were mapped in one of two mapping populations (Meridiano × Claudio and Colosseo × Lloyd) and integrated into a common genetic map. Despite the relatively low genotyping efficiency of the GG assay, the validated CRoPS-derived SNPs showed valuable features for genomics and breeding applications such as a uniform distribution across the wheat genome, a prevailing single-locus codominant nature and a high polymorphism. Here, we report a new set of 275 highly robust genome-wide Triticum SNPs that are readily available for breeding purposes.

  13. El Templum Divi Claudii. Decoración y elementos arquitectónicos para su reconstrucción

    Directory of Open Access Journals (Sweden)

    Domingo, Javier Á.

    2011-12-01

    Full Text Available To date, little data of the Templum Divi Claudii has been available. It was dedicated by Agrippina to her deified dead husband. Nothing but a schematic drawing of the FUR of the temple, done in the 16th century, as well as a few fragments of the same marble floor, belonging to the temenos. However, thanks to the discovery of some decorative architectural elements of the temple, we can finally make a volumetric reconstruction of the monument and find out how its construction fully followed the gigantic architectural tradition started by Augustus with the temple of Mars Ultor. Its measurements, virtually identical to those of this temple, also offer the possibility of linking the emperors Claudius and Vespasian, the restorer of the Claudianum, to Augustus.Hasta el momento disponíamos de pocos datos del Templum Divi Claudii, dedicado por Agripina a su difunto esposo divinizado; apenas un esquemático dibujo realizado en el s. XVI de la pieza de la FUR correspondiente al templo, así como algunos escasos fragmentos de esta misma planta marmórea correspondientes al temenos. Sin embargo, gracias a la localización de algunos elementos de la decoración arquitectónica del templo, ahora, finalmente, podemos realizar una reconstrucción volumétrica del edificio y descubrir cómo su construcción participó plenamente de la tradición de la arquitectura gigantesca iniciada por Augusto con el templo de Mars Ultor. Sus medidas, prácticamente idénticas a las de este templo, ofrecen además la posibilidad de vincular a los emperadores Claudio y Vespasiano, restaurador del Claudianum, con Augusto.

  14. In vivo anticancer evaluation of the hyperthermic efficacy of anti-human epidermal growth factor receptor-targeted PEG-based nanocarrier containing magnetic nanoparticles

    Directory of Open Access Journals (Sweden)

    Baldi G

    2014-06-01

    Full Text Available Giovanni Baldi,1 Costanza Ravagli,1 Filippo Mazzantini,1 George Loudos,2 Jaume Adan,3 Marc Masa,3 Dimitrios Psimadas,2 Eirini A Fragogeorgi,2 Erica Locatelli,4 Claudia Innocenti,5,6 Claudio Sangregorio,5,7 Mauro Comes Franchini4 1CERICOL, Sovigliana-Vinci, Italy; 2Technological Educational Institute of Athens, Athens, Greece; 3Leitat Technological Center, Barcelona, Spain; 4Department of Industrial Chemistry Toso Montanari, University of Bologna, Bologna, 5Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM, 6Dipartimento di Chimica U Schiff, Università di Firenze, Firenze, 7Centro Nazionale delle Ricerche (ICCOM – CNR, Firenze, Italy Abstract: Polymeric nanoparticles with targeting moieties containing magnetic nanoparticles as theranostic agents have considerable potential for the treatment of cancer. Here we report the chemical synthesis and characterization of a poly(D,L-lactide-co-glycolide-b-poly(ethylene glycol-based nanocarrier containing iron oxide nanoparticles and human epithelial growth factor receptor on the outer shell. The nanocarrier was also radiolabeled with 99mTc and tested as a theranostic nanomedicine, ie, it was investigated for both its diagnostic ability in vivo and its therapeutic hyperthermic effects in a standard A431 human tumor cell line. Following radiolabeling with 99mTc, the biodistribution and therapeutic hyperthermic effects of the nanosystem were studied noninvasively in vivo in tumor-bearing mice. A substantial decrease in tumor size correlated with an increase in both nanoparticle concentration and local temperature was achieved, confirming the possibility of using this multifunctional nanosystem as a therapeutic tool for epidermoid carcinoma. Keywords: magnetic nanoparticles, polymeric nanocarriers, skin cancer, hyperthermia, single-photon emission computed tomography, imaging

  15. Accelerated ischemic vascular retinopathy after intravitreally injected bevacizumab for central retinal vein occlusion in elderly patients

    Directory of Open Access Journals (Sweden)

    Isola V

    2013-03-01

    Full Text Available Vincenzo Isola,1 Alfredo Pece,1,2 Claudio Massironi,1 Simone Reposi,1 Fabio Dimastrogiovanni11Department of Ophthalmology, Melegnano Hospital, 2Fondazione Retina 3000, Milano, ItalyBackground: Ischemic changes in the retinal circulation are an uncommon but severe adverse vascular reaction to intravitreal bevacizumab (Avastin®, Genentech, San Francisco, CA, USA/Roche, Basel, Switzerland for central retinal vein occlusion (CRVO. In the two cases reported here, ischemic changes in the retina vasculature following intravitreal bevacizumab for CRVO were observed with the aim of describing the clinical and angiographic features of these changes.Methods: Two elderly patients with recent-onset CRVO received one off-label intravitreal injection of bevacizumab 0.05 mL/1.25 mg.Results: In Case 1, the patient's pre-treatment visual acuity was 20/400. At 3 weeks post injection, the patient could count fingers at a distance of 1 ft (30 cm and fluorescein angiography showed reduction in intraretinal hemorrhages and areas of retinal non-perfusion. However, at 6 weeks these were markedly increased compared with those seen in the photograph taken 3 weeks after treatment. In Case 2, the patient's pre-treatment visual acuity was 20/200. At 1 month post injection, vision had decreased to 20/400 and fluorescein angiography showed severe macular ischemia with a remarkable capillary dropout throughout the macula.Conclusion: Ischemic retinal injury may be an uncommon but severe adverse vascular reaction to intravitreal bevacizumab for CRVO. Although progression of retinal ischemia in CRVO could be observed shortly after intravitreal bevacizumab, whether this is a drug- or procedure-related effect or part of the natural history of the condition remains uncertain.Keywords: Avastin, ischemia, macular infarction, intraretinal hemorrhage, retinal non-perfusion

  16. Oraciones en plata: estudio de la obra inédita de Jacobo Pecul Montenegro

    Directory of Open Access Journals (Sweden)

    Canedo Barreiro, María

    2015-12-01

    Full Text Available The purpose of this research is the study and attribution of new pieces to Jacobo Pecul Monte negro (1753-1817 a silversmith from Santiago de Compostela. His production reflects an aesthetic clearly influenced by French forms which he learnt from his father Claudio Pecul. But also Galician artists´ work, such as Ferreiro or Simón Rodríguez, had an impact on Montenegro's own creations. Twenty four new pieces have been selected from parish crosses, holy chalices, ciboriums, censers, “navetas” and monstrances, which are referenced in Pecul's manuscript “Libro de Caja”. They were extracted by Couselo Bouzas in his Galicia Artística, and catalogued in the Diocesan Archive of the Catholic Church. These pieces have been studied and attributed to Jacobo Pecul Montenegro by the guidelines set by José Manuel López Vázquez, who has studied the work of this silversmith in depth. This article attempts to make a brief study of both the author and the silversmithing typologies in the shift from the baroque style to the neoclassical style. And at the same time this study also aims to draw attention to Galician silversmithing, which is a patrimony of our popular imagery, and more often than not highly neglected.La presente investigación tiene como objetivo el estudio y atribución de nuevas piezas al orfebre compostelano Jacobo Pecul Montenegro (1753-1817, cuya producción refleja una estética influida por una parte de las formas francesas aprendidas de su padre, Claudio Pecul, y por otra de los artistas gallegos, cómo Ferreiro o Simón Rodríguez. Se han seleccionado veinticuatro nuevas piezas entre cruces parroquiales, cálices, copones, incensarios, navetas y ostensorios, las cuales aparecen referenciadas en el Libro de Caja de Pecul, extractado por Couselo Bouzas en su Galicia Artística, y catalogadas en el Archivo Diocesano de la Iglesia Católica. Dichas obras han sido estudiadas y atribuidas a Jacobo Pecul siguiendo las directrices

  17. Biogeochemical Filtering of Solute Signals Explored as a Function of Transport and Reaction Time Scales

    Science.gov (United States)

    Zanardo, S.; Basu, N. B.; Rao, P. C.

    2009-12-01

    Catchment biogeochemical responses are the result of superposition of diverse dynamic components, which can be related to climate forcing, water flow, and biogeochemical reactions. The interactions among these components are highly non-linear and contribute to the generation of emergent patterns at multiple spatial and temporal scales. The aim of this work is to explore the following biogeochemical signatures arising from such interactions: (1) the relationship between contaminant loads (L) and discharge (Q) at the annual timescale, leading to an apparent chemostatic relationship (i.e., linear L-Q plots) for different contaminants and at different spatial scales; (2) spatial patterns in the slope and the scatter of the L-Q relationships; and (3) correlation between the intra-annual flow duration curves (FDC) and the load duration curves (LDC). Exploring this relationship necessitates the use of a parsimonious model, with few spatially uniform time constants, that can generate synthetic time series of load and flow at the outlet of river basins. The Mass Response Functions (MRF) approach (Rinaldo et al., 2006), lends itself suitable for the purpose since it relies on the assumption that the evolution of solute concentration in the water pulses depends only on the residence time, and not on its trajectory - thus space is replaced by time. The model simulates the episodic delivery of water and contaminant pulses from the hillslopes to the stream network in response to temporally random but spatially uniform effective rainfall patterns. The domain is described by an immobile source zone in which first order biogeochemical reactions (degradation rate constant ke) alter the solute mass, while multiple mobile rainfall pulses exchange mass with the source zone following linear kinetics (mass transfer rate constant α). The biogeochemical module of MRF, that was originally written to simulate non-reactive tracer and nitrate transport, was modified to include the more

  18. The big bang of hemofiltration: the beginning of a new era in the third millennium for extra-corporeal blood purification!

    Science.gov (United States)

    Honore', P M; Joannes-Boyau, O; Merson, L; Boer, W; Piette, V; Galloy, A-C; Janvier, G

    2006-07-01

    Since the last decade, hemofiltration and especially high volume hemofiltration has rapidly evolved from a somewhat experimental treatment towards a potentially effective 'adjunctive' therapy in severe septic shock and especially refractory or catecholamine resistant hypodynamic septic shock. Nevertheless, this approach lacks prospective randomized studies (PRT'S) evaluating the critical role of early hemofiltration in sepsis. An important step forward which could be called the 'big bang' in term of hemofiltration was the publication of a PRT in patients with acute renal failure (ARF) (1). Before this study (2), nobody believed that hemofiltration could change the survival rate in intensive care. Since that big bang, many physicians consider that hemofiltration at a certain dose can change the survival rate in intensive care. So the world of hemofiltration in ICU is not a definitive world, it is still in expansion. Indeed, we now have to try to define what will be the exact dose we need in septic acute renal failure. This dose might well be 'higher' than 35 ml/kg/hour in the septic acute renal failure 'group' as suggested by many studies (2-5). At present, it is the issue of continuous dose of high volume hemofiltration that has to be tested in future randomized studies. Since the Vicenza study (2) has shown that 35 ml/kg/h is the best dose in terms of survival, dealing with non septic acute renal failure in ICU, several studies from different groups have shown that, in septic acute renal failure, a higher dose might correlate with better survival. This has also been shown in some way by the study of the 'Vicenza group' but not with a statistically significant value (2). New PRT'S have just started in Europe like the IVOIRE study (hIgh VOlume in Intensive caRE) (6) and the RENAL study. Another large study is looking more basically at dose in non septic acute renal failure in Australasia and is led by the group of Rinaldo Bellomo in Melbourne (7) as well as the ATN

  19. Watershed Hydrologic Response and Drainage Network Topology Across a Spectrum of Urban Development Patterns

    Science.gov (United States)

    Miller, A. J.; Lindner, G. A.; Shamer, S. Z.; Schmidt, K. M.; Kather, M. J.; Jones, D.; Baker, M. E.; Welty, C.

    2012-12-01

    to assess the role of watershed size, shape and urban drainage network properties, we have developed binary hydrography layers that incorporate storm drains and paved surfaces as part of the channel network. We use the augmented drainage network in order to derive width functions, or probability density functions for flowpath distance upstream of the watershed outlet. The width functions provide idealized representations of hydrologic response for watersheds of similar size and different development pattern by using ratios of channel to hillslope velocity similar to those used by Rinaldo et al. (1995), D'Odorico and Rigon (2002) and Smith et al. (2005). These are compared with the empirically derived hydrologic response signatures. Initial results suggest that the width function is able to mimic differences in hydrograph shape across a set of watersheds with distinctive patterns of hydrologic response. Additional work will include simplified approaches to account for the effect of stormwater management.

  20. PREFACE: Young Researcher Meeting in Rome 2012

    Science.gov (United States)

    Agostini, Fabio; Cattani, Giordano; Mazzaferro, Luca; Migliaccio, Marina; Pietrobon, Davide; Ricci Pacifici, Daniel; Stellato, Francesco; Veneziani, Marcella

    2012-10-01

    (Daniel.Ricci.Pacifici@roma2.infn.it) Dipartimento di Fisica, Università di Roma 'Tor Vergata' INFN sezione di Roma 'Tor Vergata' Via della Ricerca Scientifica 1, 00133 Roma Italy Francesco Stellato (francesco.stellato@cfel.de) Center for Free Electron Laser science c/o DESY 22607 Hamburg Germany Marcella Veneziani (marcella.veneziani@caltech.edu) California Institute of Technology 1200 California Blvd, Pasadena, 91125, CA USA Institution logos Acknowledgments The organizers of the 3rd Young Researcher Meeting in Rome would like to thank all the scientists who participated in the meeting. We thank the Science Faculty of the University of Rome 'Tor Vergata' for hosting the conference. The 'Tor Vergata' Division of the National Institute for Nuclear Physics (INFN) and the Department of Physics of the University of Rome 'Tor Vergata' who have sponsored the event, covering the organization costs and allowing for travel grants to the speakers. We are grateful to Professor Francesco Fucito, Professor Piergiorgio Picozza, Professor Rinaldo Santonico, Dr Jose Francisco Morales and Ms Francesca Luna for their valuable support.

  1. The KULTURisk Regional Risk Assessment methodology for water-related natural hazards - Part 1: Physical-environmental assessment

    Science.gov (United States)

    Ronco, P.; Gallina, V.; Torresan, S.; Zabeo, A.; Semenzin, E.; Critto, A.; Marcomini, A.

    2014-12-01

    , exposure and vulnerability. It integrates the outputs of various hydrodynamic models with site-specific bio-geophysical and socio-economic indicators (e.g. slope, land cover, population density, economic activities etc.) to develop tailored risk indexes and GIS-based maps for each of the selected receptors (i.e. people, buildings, infrastructure, agriculture, natural and semi-natural systems, cultural heritage) in the considered region. It further compares the baseline scenario with alternative scenarios, where different structural and/or non-structural mitigation measures are planned and eventually implemented. As demonstrated in the companion paper (Part 2, Ronco et al., 2014), risk maps, along with related statistics, allow one to identify and classify, on a relative scale, areas at risk which are more likely to be affected by floods and support the development of strategic adaptation and prevention measures to minimizing flood impacts. In addition, the outcomes of the RRA can be eventually used for a further socio-economic assessment, considering the tangible and intangible costs as well as the human dimension of vulnerability.

  2. Avaliação da pressão inspiratória em crianças com aumento do volume de tonsilas Evaluation of inspiratory pressure in children with enlarged tonsils and adenoids

    Directory of Open Access Journals (Sweden)

    Melissa Guerato Pires

    2005-10-01

    Full Text Available Crianças com aumento do volume de tonsilas palatina e faríngea freqüentemente apresentam anormalidades respiratórias tais como ronco, respiração oral e apnéia do sono. Sabe-se que a obstrução de vias aéreas superiores e conseqüentemente a respiração oral podem resultar em problemas pulmonares. OBJETIVO: Avaliar a pressão inspiratória em crianças com obstrução de vias aéreas superiores devido ao aumento do volume de tonsilas. FORMA DE ESTUDO: clínico com coorte transversal. MATERIAL E MÉTODO: Nós avaliamos 37 crianças (4-13 anos, ambos os sexos com aumento do volume de tonsilas que seriam submetidas à cirurgia de Adenoamigdalectomia na Divisão de Otorrinolaringologia da Universidade de São Paulo no mesmo período. O grupo controle foi composto de 28 crianças sem aumento de volume tonsilar que foram submetidas aos mesmos testes. A pressão Inspiratória foi obtida pelo uso do manovacuômetro. RESULTADOS: Observamos uma menor pressão inspiratória no grupo com aumento do volume de tonsilas. A média do grupo com aumento do volume das tonsilas foi 14,607 cm/H2O e do grupo normal foi de 27,580 cm/H2O (PChildren with enlarged tonsils and adenoids usually present breathing abnormalities such as snoring, mouth breathing and sleep apnea. It is known that upper airway obstruction and consequent mouth breathing may result in pulmonary diseases. AIM: The goal of this preliminary study was to evaluate the inspiratory pressure in children with upper airway obstruction due to enlarged tonsils. STUDY DESIGN: clinical with transversal cohort. MATERIAL AND METHOD: We evaluated 37 children (4 -13 years old, female/male with enlarged tonsils who would be submitted to a T&A surgery in the Department of Otolaryngology, Medical School, University of Sao Paulo, from October 2002 to March 2003. The control group comprised 28 children without tonsillar disease submitted to the same tests. Inspiratory pressure was obtained using a manometer and

  3. Obstrução nasal e alto escore de Mallampati como fatores de risco associados para Apneia Obstrutiva do Sono Nasal obstruction and high Mallampati score as risk factors for Obstructive Sleep Apnea

    Directory of Open Access Journals (Sweden)

    Marcos Marques Rodrigues

    2010-10-01

    Full Text Available Os distúrbios respiratórios do sono estão associados à perviedade das vias aéreas superiores. Obstrução nasal é associada com o aumento de eventos de apneia do sono, principalmente pelo aumento da pressão negativa imposta às vias aéreas durante a inspiração. OBJETIVO: Avaliar a influência da obstrução nasal associada à classificação modificada de Mallampati na gravidade da SAOS. MATERIAIS E MÉTODOS: Foram avaliados e classificados 206 pacientes com queixa de roncos e história sugestiva de SAOS através do Escore Modificado de Mallampati, Friedman, obstrução nasal e quanto à gravidade da SAOS pelo IAH. RESULTADOS: Foram incluídos 168 pacientes que se submeteram ao estudo de polissonografia no laboratório de sono. Uma crostabulação foi feita entre o escore modificado de Mallampati, obstrução nasal e o IAH. O Oddis Ratio entre alto escore de Mallampati e IAH foi OR=5,053, IC 95%=1,458 - 7,517(p = 0,0071. Alto Mallampati associado com obstrução nasal se correlacionam com SAOS (p=0,0227. Entretanto, a influência da obstrução nasal sobre a relação do alto escore de Mallampati e SAOS não foi significativa OR = 2,850, IC 95%=0,992 - 8,189. CONCLUSÃO: A associação de alto escore de Mallampati e obstrução nasal é fator de risco para agravamento da SAOS.Respiratory sleep disorders are strongly associated with upper airway patency. Nasal obstruction is associated with higher incidences of sleep apnea, primarily by increasing the negative pressure on the airway during inspiration. AIMS: To evaluate the influence of nasal obstruction in the worsening of sleep apnea in patients with OSA and a high score on the modified classification of Mallampati. MATERIALS AND METHODS: We evaluated and classified 206 patients complaining of snoring, and with a past suggestive of OSA through the Modified Mallampati score, Friedman, nasal obstruction and the severity of OSA by AHI. RESULTS: 168 patients who underwent polysomnography

  4. Uso de preditores clínicos simples no diagnóstico pré-operatório de dificuldade de intubação endotraqueal em pacientes portadores de obesidade

    Directory of Open Access Journals (Sweden)

    Edno Magalhães

    2013-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Apesar da semelhante incidência de dificuldade à laringoscopia em obesos e não obesos há mais relatos de dificuldade de intubação endotraqueal em portadores de obesidade. Alternativas de diagnóstico e previsão de dificuldade de intubação no pré-operatório podem ajudar diminuir complicações anestésicas em indivíduos obesos. O objetivo do estudo foi identificar preditores para diagnóstico de via aérea difícil em pacientes obesos, pela correlação com métodos clínicos de avaliação pré-anestésica e polissonografia. Comparou-se também a incidência de dificuldade à ventilação sob máscara facial e à laringoscopia entre obesos e não obesos, verificando os preditores mais prevalentes. MÉTODOS: Estudo observacional, prospectivo, comparativo, com 88 pacientes adultos, submetidos à anestesia geral. No período pré-operatório, avaliou-se questionário sobre preditores clínicos de síndrome da apneia obstrutiva do sono (SAOS e parâmetros anatômicos. Durante a anestesia, pesquisou-se dificuldade à ventilação sob máscara facial e laringoscopia. Para análise, estatística descritiva e teste de correlação. RESULTADOS: Os pacientes foram alocados em dois grupos, 43 obesos e 45 não obesos. Estado físico, prevalência de roncos, hipertensão e diabetes mellitus, circunferência cervical e índice de Mallampati foram maiores nos obesos. Pacientes obesos apresentaram maior incidência de dificuldade de ventilação sob máscara e laringoscopia. Nenhuma variável clínica ou anatômica apresentou correlação com dificuldade de ventilação sob máscara nos grupos. Nos obesos, o diagnóstico de SAOS mostrou forte correlação com dificuldade à laringoscopia. CONCLUSÕES: Os diagnósticos clínico e polissonográfico de SAOS se mostraram úteis no diagnóstico pré-operatório de dificuldade à laringoscopia. Pacientes obesos estão mais propensos à dificuldade de ventilação sob máscara e

  5. The KULTURisk Regional Risk Assessment methodology for water-related natural hazards - Part 1: Physical-environmental assessment

    Science.gov (United States)

    Ronco, P.; Gallina, V.; Torresan, S.; Zabeo, A.; Semenzin, E.; Critto, A.; Marcomini, A.

    2014-07-01

    KR-RRA methodology is based on the concept of risk being function of hazard, exposure and vulnerability. It integrates the outputs of various hydrodynamics models (hazard) with sito-specific bio-geophysical and socio-economic indicators (e.g. slope, land cover, population density, economic activities) to develop tailored risk indexes and GIS-based maps for each of the selected targets (i.e. people, buildings, infrastructures, agriculture, natural and semi-natural systems, cultural heritages) in the considered region, by comparing the baseline scenario with alternative scenarios, where different structural and/or non-structural mitigation measures are planned. As demonstrated in the companion paper (Part 2, Ronco et al., 2014), risk maps, along with related statistics, allow to identify and prioritize relative hotspots and targets which are more likely to be affected by flood and support the development of relevant and strategic adaptation and prevention measures to minimizing flood impacts. Moreover, the outputs of the RRA methodology can be used for the economic evaluation of different damages (e.g. tangible costs, intangible costs) and for the social assessment considering the benefits of the human dimension of vulnerability (i.e. adaptive and coping capacity).

  6. Influência do biofeedback respiratório associado ao padão quiet breathing sobre a função pulmonar e hábitos de respiradores bucais funcionais Influence of respiratory biofeedback associated with a quiet breathing pattern on the pulmonary function and habits of functional mouth breathers

    Directory of Open Access Journals (Sweden)

    EF Barbiero

    2007-10-01

    Full Text Available OBJETIVOS: Avaliar os efeitos da utilização do biofeedback respiratório (BR associado ao padrão quiet breathing sobre a perimetria torácica, função pulmonar, força dos músculos respiratórios e os seguintes hábitos de respiradores bucais funcionais (RBF: vigília de boca aberta, boca aberta durante o sono, baba no travesseiro, despertar difícil, ronco e sono inquieto. MÉTODOS: Foram avaliadas 20 crianças RBF, as quais foram submetidas a 15 sessões de BR por meio do biofeedback pletsmovent (MICROHARD® V1.0, o qual proporciona o biofeedback dos movimentos tóraco-abdominais. Perimetria torácica, espirometria e medidas das pressões respiratórias máximas estáticas foram realizadas antes e após a terapia. Questões respondidas pelos responsáveis foram utilizadas para avaliar os hábitos dos RBF. Os dados foram analisados por meio de teste t de Student para dados pareados e testes não paramétricos. RESULTADOS: O uso do BR associado ao padrão quiet breathing não produziu alterações significativas na perimetria torácica e nos valores de volume expiratório forçado no primeiro segundo (VEF1, capacidade vital forçada (CVF, pico de fluxo expiratório (PFE, índice de Tiffeneau (IT e na pressão expiratória máxima (PEmáx. Entretanto, a pressão inspiratória máxima (PImáx apresentou diferença estatisticamente significativa (-53,6 ± 2,9 cmH2O vs. -65,0 ± 6,0 cmH2O; pOBJECTIVE: To evaluate the effects of using respiratory biofeedback associated with a quiet breathing pattern, on chest circumference, pulmonary function, respiratory muscle strength and the following functional mouth-breathing habits: watching things with mouth open, sleeping with mouth open, dribbling on the pillow, difficulty in waking up, snoring and restlessness during sleep. METHOD: Twenty functional mouth-breathing children were evaluated. They underwent 15 sessions of respiratory biofeedback by means of the biofeedback pletsmovent (MICROHARD® V1

  7. Atualização em síndrome da apnéia obstrutiva do sono na infância Update in obstructive sleep apnea syndrome in children

    Directory of Open Access Journals (Sweden)

    Aracy P. S. Balbani

    2005-02-01

    Full Text Available A prevalência de SAOS em crianças é de 0,7-3%, com pico de incidência nos pré-escolares. Fatores anatômicos (obstrução nasal severa, más-formações craniofaciais, hipertrofia do tecido linfático da faringe, anomalias laríngeas, etc. e funcionais (doenças neuromusculares predispõem à SAOS na infância. A principal causa da SAOS em crianças é a hipertrofia adenotonsilar. As manifestações clínicas mais comuns são: ronco noturno, pausas respiratórias, sono agitado e respiração bucal. A oximetria de pulso noturna, a gravação em áudio ou vídeo dos ruídos respiratórios noturnos e a polissonografia breve diurna são métodos úteis para triagem dos casos suspeitos de SAOS em crianças, e o padrão-ouro para diagnóstico é a polissonografia em laboratório de sono durante uma noite inteira. Ao contrário dos adultos com SAOS, as crianças costumam apresentar: menos despertares associados aos eventos de apnéia, maior número de apnéias/hipopnéias durante o sono REM e dessaturação mais acentuada da oxihemoglobina mesmo nas apnéias de curta duração. O tratamento da SAOS pode ser cirúrgico (adenotonsilectomia, correção de anomalias craniofaciais, traqueostomia ou clínico (higiene do sono, pressão positiva contínua nas vias aéreas - CPAP.The prevalence of OSAS in children is 0.7-3%, with peak incidence in pre-schoolers. It is characterised by partial or complete upper airway obstruction during sleep, causing intermittent hypoxia. Both anatomical (severe nasal obstruction, craniofacial anomalies, hypertrophy of the pharyngeal lymphoid tissue, laryngeal anomalies, etc. and functional factors (neuromuscular diseases predispose to OSAS during childhood. The main cause of OSAS in children in adenotonsillar hypertrophy. The most common clinical manifestations of OSAS are: nocturnal snoring, respiratory pauses, restless sleep and mouth breathing. Nocturnal pulse oximetry, nocturnal noise audio/videotape recording and nap

  8. Pediatras e os distúrbios respiratórios do sono na criança Pediatricians and sleep-disordered breathing in the child

    Directory of Open Access Journals (Sweden)

    Aracy Pereira Silveira Balbani

    2005-04-01

    Full Text Available OBJETIVOS: pesquisar as opiniões e condutas de pediatras frente aos distúrbios respiratórios do sono (DRS em crianças. MÉTODOS: Foram selecionados aleatoriamente 516 pediatras do Estado de São Paulo. Foi enviado aos pediatras, por correio, um formulário de questões sobre: perfil profissional, seu conhecimento do DRS na criança, opiniões e condutas para diagnóstico e tratamento dessa doença. RESULTADOS: Retornaram preenchidos 112 questionários anônimos (21,7%. O ensino de DRS na infância durante a graduação e a residência médica em Pediatria foi considerado insatisfatório, respectivamente, por 65,2% e 34,8% dos pediatras. Quarenta e nove pediatras (43,8% avaliaram seu conhecimento de DRS na criança como regular, 39 (34,8% como bom e 17 (15,2% como insatisfatório. As questões de anamnese do sono consideradas mais importantes foram: respiração bucal, pausas respiratórias, número de horas de sono, sonolência diurna excessiva e chiado noturno. Os dados clínicos considerados mais importantes para a suspeita de síndrome da apnéia obstrutiva do sono (SAOS foram: pausas respiratórias, hipertrofia da adenóide, respiração bucal, presença de anomalia craniofacial e ronco. As principais condutas citadas para diagnóstico de SAOS na criança foram: radiografia do cavum e avaliação com otorrinolaringologista (25% e oximetria de pulso noturna (14,2%. Somente 11,6% dos pediatras indicaram a polissonografia de noite inteira e 4,5%, a polissonografia breve diurna. As condutas consideradas mais eficazes para tratamento de DRS foram: cirurgias de adenoidectomia e adenotonsilectomia, orientação aos pais, perda de peso e higiene do sono. CONCLUSÕES: Há um descompasso entre as pesquisas sobre DRS na infância e sua abordagem na prática pediátrica.OBJECTIVES: assessment of opinions and practices of pediatricians concerning sleep-disordered breathing (SDB in children. METHODS: randomly 516 pediatricians were selected in the

  9. Knowledge among physical education professionals about poliomyelitis and post-poliomyelitis syndrome: a cross-sectional study in Brazil

    Directory of Open Access Journals (Sweden)

    Sousa BS

    2013-08-01

    Full Text Available Claudio Andre Barbosa de Lira,1 Taíza Márcia de Almeida Alves,1 Luiz Fernando Peixinho-Pena,2 Bolivar Saldanha Sousa,3,4 Marcos Gonçalves de Santana,1 Sandra Aparecida Benite-Ribeiro,1 Marilia dos Santos Andrade,2 Rodrigo Luiz Vancini21Setor de Fisiologia Humana e do Exercício, Universidade Federal de Goiás, Câmpus Jataí, Jataí, 2Departamento de Fisiologia, Universidade Federal de São Paulo, São Paulo, Brazil; 3Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brazil; 4Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, BrazilBackground: Post-poliomyelitis syndrome is a clinical condition that can affect poliomyelitis survivors with the onset of new symptoms several years after the acute disease. These symptoms include new muscular weakness, fatigue, pain, onset or aggravation of muscle atrophy, muscle cramps, onset or aggravation of pre-existing difficulties in accomplishing daily life activities, cold intolerance, sleep disorders, dysphonia or dysphagia, and respiratory deficiency. The treatment of post-poliomyelitis syndrome requires a multiprofessional health team because the rehabilitation procedures include lifestyle changes, physiotherapy, avoidance of secondary complications, and physical exercise. As physical exercise is prescribed by physical education professionals, the assessment of knowledge about post-poliomyelitis syndrome among these professionals is very relevant. The aim of this study was to evaluate poliomyelitis and post-poliomyelitis syndrome knowledge among physical education professionals in Brazil.Methods: We invited participants with an academic degree in physical education (n = 217 to participate in this study. A self-administered survey (30 questions was designed to probe knowledge about poliomyelitis and post-poliomyelitis syndrome. From the survey, we created a questionnaire to evaluate the performance of the professionals. The questionnaire was composed of 20

  10. Development of a core outcome set for medication review in older patients with multimorbidity and polypharmacy: a study protocol

    Directory of Open Access Journals (Sweden)

    Beuscart JB

    2017-08-01

    Full Text Available Jean-Baptiste Beuscart,1 Olivia Dalleur,1 Benoit Boland,2 Stefanie Thevelin,1 Wilma Knol,3 Shane Cullinan,4 Claudio Schneider,5 Denis O’Mahony,6 Nicolas Rodondi,4,7 Anne Spinewine1,8 1Université catholique de Louvain, Louvain Drug Research Institute, Clinical Pharmacy Research Group, Brussels, Belgium; 2Geriatric Medicine, Cliniques universitaires Saint-Luc, Brussels, Université catholique de Louvain, Belgium; 3Department of Geriatric Medicine and Expertise Centre Pharmacotherapy in Old Persons (EPHOR, University Medical Centre Utrecht, Netherlands; 4School of Pharmacy, Royal College of Surgeons in Ireland, Dublin, Ireland; 5Department of General Internal Medicine, Bern University Hospital, Bern, Switzerland; 6Department of Medicine (Geriatrics, University College Cork, Cork, Ireland; 7Institute of Primary Health Care (BIHAM, University of Bern, Bern, Switzerland; 8Université catholique de Louvain, CHU UCL Namur, Pharmacy Department, Yvoir, Belgium Background: Medication review has been advocated to address the challenge of polypharmacy in older patients, yet there is no consensus on how best to evaluate its efficacy. Heterogeneity of outcomes reported in clinical trials can hinder the comparison of clinical trial findings in systematic reviews. Moreover, the outcomes that matter most to older patients might be under-reported or disregarded altogether. A core outcome set can address this issue as it defines a minimum set of outcomes that should be reported in all clinical trials in any particular field of research. As part of the European Commission-funded project, called OPtimising thERapy to prevent Avoidable hospital admissions in the Multimorbid elderly, this paper describes the methods used to develop a core outcome set for clinical trials of medication review in older patients with multimorbidity. Methods/design: The study was designed in several steps. First, a systematic review established which outcomes were measured in published

  11. Reduction of group A beta-hemolytic streptococcus pharyngo-tonsillar infections associated with use of the oral probiotic Streptococcus salivarius K12: a retrospective observational study

    Directory of Open Access Journals (Sweden)

    Gregori G

    2016-01-01

    Full Text Available Giuseppe Gregori,1 Ornella Righi,1 Paolo Risso,2 Goffreda Boiardi,1 Giovanni Demuru,1 Anna Ferzetti,1 Antonio Galli,1 Marco Ghisoni,1 Sonia Lenzini,1 Claudio Marenghi,1 Caterina Mura,1 Roberto Sacchetti,1 Lucia Suzzani1 1Primary Care Department, Local Health Unit (ASL, Piacenza, 2Department of Health Science (DISSAL, University of Genoa, Genoa, Italy Abstract: Recurrent pharyngo-tonsillar infections caused by group A beta-hemolytic streptococci (GABHS occur frequently in young children, and the treatment of these infections contributes substantially to the total current requirement for antibiotic prescribing. Our study goal was to assess through a retrospective observational analysis whether the administration of the oral probiotic, Streptococcus salivarius K12 (SsK12, could reduce the occurrence of GABHS pharyngo-tonsillar infections in children who had a recent history of recurrent episodes of these infections. Twelve primary care pediatricians identified, through their databases, a total of 130 children who had experienced recurrent GABHS pharyngo-tonsillar infections over a period of at least 6–12 months prior to their inclusion in the study. Of these children, 76 then undertook a 90-day program requiring once-a-day dosing with a commercially available (Bactoblis lozenge containing SsK12. No probiotic supplement was given to the remaining 54 (control children. Each subject was monitored for the occurrence of GABHS pharyngo-tonsillitis and also for acute otitis media, bronchitis, sinusitis, and bronchopneumonia for at least 12 months following their entry to the study. Even 9 months after the use of SsK12 had been stopped, the probability of new GABHS infections was significantly lower (P>0.001 when compared to the period before dosing commenced. When compared to the untreated children, those taking SsK12 appear to have had significantly fewer GABHS infections both during the 90-day period of prophylaxis and during the following 9

  12. Observational evaluation of preoperative, intraoperative, and postoperative characteristics in 117 Brazilian women without uterine prolapse undergoing vaginal hysterectomy

    Directory of Open Access Journals (Sweden)

    Osako MT

    2012-09-01

    Full Text Available Claudio Sergio Batista,1 Takasi Osako,2 Eliana Mara Clemente,2 Fernanda Carvalhido Antonio Batista,3 Maurício Takeshi Janiques Osako41Department of Gynecology and Obstetrics of Faculty of Medicine of Petropolis, Petropolis, Rio de Janeiro, Brazil; 2Gynecology and Obstetrics, Casa Providencia Hospital, Petropolis, Rio de Janeiro, Brazil; 3School of Medicine of Technical Educational Foundation Souza Marques, Rio de Janeiro, Brazil; 4School of Medicine of University Gama Filho, Rio de Janeiro, BrazilBackground: Despite the introduction of minimally invasive approaches for various benign uterine problems, hysterectomy is often still performed abdominally, but the vaginal route should be used whenever possible. The aim of this study was to identify the preoperative, intraoperative, and postoperative characteristics of women undergoing vaginal hysterectomy in the absence of uterine prolapse.Methods: A prospective, descriptive, quantitative, noncomparative study was conducted in 117 women between August 2009 and February 2011 in Petropolis, Rio de Janeiro, Brazil. The women included had a uterine indication for hysterectomy, their surgeries were performed by the same team, and they were followed up for 12 months. An adapted Pelvic Organ Prolapse Quantification system was used to check for uterine prolapse.Results: The age range of the women was 33–59 years, uterine volume was 300–900 mL, and 73.50% has undergone prior cesarean section. The main indication for hysterectomy was uterine myoma (64.95%, with a surgery time of 30–60 minutes in 55 (59.82% and 19 (15.98% cases, respectively. Uterine volume reduction was performed in 41 (35.05% cases, salpingectomy was the most common associated surgery (81.19%, and anesthesia was subdural (68.37%. Common intraoperative complications included bladder lesions (8.54%, with conversion to the abdominal route being necessary in one case (1.28%, and the most common postoperative complication being vaginal

  13. Dose-response curve to salbutamol during acute and chronic treatment with formoterol in COPD

    Directory of Open Access Journals (Sweden)

    La Piana GE

    2011-07-01

    Full Text Available Giuseppe Emanuele La Piana¹, Luciano Corda², Enrica Bertella¹, Luigi Taranto Montemurro¹, Laura Pini¹, Claudio Tantucci¹¹Cattedra di Malattie dell'Apparato Respiratorio, Università di Brescia, ²Prima Divisione di Medicina Interna, Spedali Civili, Brescia, ItalyBackground: Use of short-acting ß2-agonists in chronic obstructive pulmonary disease (COPD during treatment with long-acting ß2-agonists is recommended as needed, but its effectiveness is unclear. The purpose of this study was to assess the additional bronchodilating effect of increasing doses of salbutamol during acute and chronic treatment with formoterol in patients with COPD.Methods: Ten patients with COPD underwent a dose-response curve to salbutamol (until 800 µg of cumulative dose after a 1-week washout (baseline, 8 hours after the first administration of formoterol 12 µg (day 1, and after a 12-week and 24-week period of treatment with formoterol (12 µg twice daily by dry powder inhaler. Peak expiratory flow, forced expiratory volume in one second (FEV1, forced vital capacity, and inspiratory capacity were measured at the different periods of treatment and at different steps of the dose-response curve.Results: Despite acute or chronic administration of formoterol, maximal values of peak expiratory flow, FEV1, and forced vital capacity after 800 µg of salbutamol were unchanged compared with baseline. The baseline FEV1 dose-response curve was steeper than that at day 1, week 12, or week 24 (P < 0.0001. Within each dose-response curve, FEV1 was different only at baseline and at day 1 (P < 0.001, when FEV1 was still greater at 800 µg than at 0 µg (P < 0.02. In contrast, the forced vital capacity dose-response curves were similar at the different periods, while within each dose-response curve, forced vital capacity was different in all instances (P < 0.001, always being higher at 800 µg than at 0 µg (P < 0.05.Conclusion: In patients with stable COPD, the maximal effect

  14. CIL, II²/5, 316 (Igabrum y la cronología de los primeros flamines provinciales de la Bética

    Directory of Open Access Journals (Sweden)

    Goffaux, Bertrand

    2013-12-01

    Full Text Available A new reading is given for the CIL, II²/5, 316 inscription, from Igabrum (Cabra, Córdoba, based on a revision of the manuscript tradition. This manuscript gave the curriculum of a knight from Baetica, who had been praefectus fabrum, then military tribune in the legio VI Victrix, and then magistrate in the colonia Patricia, finally reaching the provincial flaminate. Such a career, including local honores after the sequence praefectura fabrum – military tribunate, is typical of the Augustan and Julio-Claudian period, which leads to a revision of the chronology of the document which could date back to the end of the Julio-Claudians, or the very beginning of the Flavian dynasty. Such a chronology raises questions about the origins of the provincial flaminate of Baetica, and about the commonly-accepted assumption that it was a Flavian creation.A partir de una revisión de la tradición manuscrita, se propone una nueva lectura de la inscripción CIL, II²/5, 316, de Igabrum (Cabra, Córdoba, que se refiere a la carrera de un caballero de la Bética. Su cursus hubiera incluido un nivel local, como magistrado de la colonia Patricia, después del ejercicio de la praefectura fabrum y del tribunado militar de la legio VI Victrix, y antes de su elección al flaminado provincial. La presencia de una función a nivel local, después de la sucesión praefectus fabrum – tribuno militar, es típica de los tiempos de Augusto o de los Julio-Claudios, y lleva a una revisión de la fecha del documento que podría colocarse al final de la época Julio-Claudia, o muy temprano en la época Flavia. Esta nueva cronología requiere interrogarse acerca de los orígenes del flaminado provincial de la Bética, y volver a examinar los criterios que llevaron a situar su creación bajo los emperadores Flavios.

  15. Efficacy of CR4056, a first-in-class imidazoline-2 analgesic drug, in comparison with naproxen in two rat models of osteoarthritis

    Directory of Open Access Journals (Sweden)

    Comi E

    2017-05-01

    Full Text Available Eleonora Comi,1,2 Marco Lanza,1 Flora Ferrari,1 Valeria Mauri,1,3 Gianfranco Caselli,1 Lucio Claudio Rovati1 1Department of Pharmacology and Toxicology, Rottapharm Biotech, 2PhD Program in Neuroscience, University of Milan-Bicocca, 3Department of Surgery and Translational Medicine, University of Milan-Bicocca, Monza, Italy Purpose: CR4056, (2-phenyl-6-(1H-imidazol-1yl quinazoline, an imidazoline-2 (I2 receptor ligand, is a promising analgesic drug that has been reported to be effective in several animal models of pain. The aim of this study was to evaluate the effects of CR4056 in two well-established rat models of osteoarthritis (OA, mimicking the painful and structural components of human OA.Methods: Knee OA was induced either by single intra-articular injection of monoiodoacetate (MIA or by medial meniscal tear (MMT in the right knee of male rats. In the MIA model, allodynia and hyperalgesia were measured as paw withdrawal threshold to mechanical stimulation. In the MMT model, pain behavior was analyzed as weight-bearing asymmetry (i.e. difference in hind paw weight distribution, HPWD between the injured and the contralateral limbs.Results: Acute oral administration of CR4056, 14 days after MIA injection, significantly and dose-dependently reduced allodynia and hyperalgesia 90 minutes after treatment, whereas acute naproxen administration significantly reduced allodynia but not hyperalgesia. After 7 days of repeated treatment, both CR4056 and naproxen showed significant anti-allodynic and anti-hyperalgesic effects in the MIA model. Rats undergoing MMT surgery developed a significant and progressive asymmetry in HPWD compared with sham-operated animals. Repeated treatment with CR4056 significantly reduced the progression of the pain behavior, whereas naproxen had no effects.Conclusion: The data presented here show that the I2 ligand CR4056 could be a new effective treatment for OA pain. The compound is currently under Phase II clinical

  16. Surgery in asymptomatic patients with colorectal cancer and unresectable liver metastases: the authors' experience

    Directory of Open Access Journals (Sweden)

    Boselli C

    2013-03-01

    Full Text Available Carlo Boselli,1 Claudio Renzi,2 Alessandro Gemini,1 Elisa Castellani,1 Stefano Trastulli,2 Jacopo Desiderio,2 Alessia Corsi,2 Francesco Barberini,1 Roberto Cirocchi,2 Alberto Santoro,3 Amilcare Parisi,4 Adriano Redler,3 Giuseppe Noya1 1Department of General and Oncologic Surgery, University of Perugia, Perugia, 2Department of General Surgery, University of Perugia, St Maria Hospital, Terni, 3Department of Surgical Sciences, Sapienza University of Rome, Rome, 4Department of Digestive Surgery, St Maria Hospital, Terni, Italy Purpose: In asymptomatic patients with Stage IV colorectal cancer, the debate continues over the efficacy of primary resection compared to chemotherapy alone. The aim of this study was to define the optimal management for asymptomatic patients with colorectal cancer and unresectable liver metastases. Patients and methods: Patients receiving elective surgery (n = 17 were compared to patients receiving chemotherapy only (n = 31. Data concerning patients' demographics, location of primary tumor, comorbidities, performance status, Child–Pugh score, extension of liver metastases, size of primary, and other secondary locations were collected. Results: Thirty-day mortality after chemotherapy was lower than that after surgical resection (19.3% versus 29.4%; not significant. In patients with >75% hepatic involvement, mortality at 1 month was higher after receiving surgical treatment than after chemotherapy alone (50% versus 25%. In patients with <75% hepatic involvement, 30-day mortality was similar in both groups (not significant. Thirty-day mortality in patients with Stage T3 was lower in those receiving chemotherapy (16.7% versus 30%; not significant. Overall survival was similar in both groups. The risk of all-cause death after elective surgery (2.1 was significantly higher than in patients receiving chemotherapy only (P = 0.035. Conclusion: This study demonstrated that in palliative treatment of asymptomatic unresectable Stage

  17. Resistance training associated with the administration of anabolic-androgenic steroids improves insulin sensitivity in ovariectomized rats

    Directory of Open Access Journals (Sweden)

    Urtado CB

    2011-11-01

    Full Text Available Christiano Bertoldo Urtado1,2, Guilherme Borges Pereira3, Marilia Bertoldo Urtado4, Érica Blascovi de Carvalho2, Gerson dos Santos Leite1, Felipe Fedrizzi Donatto1, Claudio de Oliveira Assumpção1, Richard Diego Leite3, Carlos Alberto da Silva1, Marcelo Magalhães de Sales5, Ramires Alsamir Tibana5, Silvia Cristina Crepaldi Alves1, Jonato Prestes51Health Sciences, Methodist University of Piracicaba, Piracicaba, SP, 2Center for Investigation in Pediatrics, Faculty of Medical Sciences, State University of Campinas, Campinas, SP, 3Department of Physiological Sciences, Federal University of São Carlos, São Carlos, SP, 4Laboratory of Orofacial Pain, Division of Oral Physiology, Piracicaba Dental School, State University of Campinas, Campinas, SP, 5Graduation Program in Physical Education, Catholic University of Brasilia, Brasilia, DF, BrazilAbstract: The aim of the present study was to investigate the effects of anabolic-androgenic steroids and resistance training (RT on insulin sensitivity in ovariectomized rats. Adult female Wistar rats were divided into ten experimental groups (n = 5 animals per group: (1 sedentary (Sed-Intact; (2 sedentary ovariectomized (Sed-Ovx; (3 sedentary nandrolone (Sed-Intact-ND; (4 sedentary ovariectomized plus nandrolone (Sed-Ovx-ND; (5 trained (TR-Intact; (6 trained nandrolone (TR-Intact-ND; (7 trained ovariectomized (TR-Ovx; (8 trained ovariectomized plus nandrolone; (9 trained sham; and (10 trained ovariectomized plus sham. Four sessions of RT were used, during which the animals climbed a 1.1 m vertical ladder with weights attached to their tails. The sessions were performed once every 3 days, with between four and nine climbs and with eight to twelve dynamic movements per climb. To test the sensitivity of insulin in the pancreas, glucose and insulin tolerance tests were performed. For insulin sensitivity, there was a statistically significant interaction for the TR-Ovx group, which presented higher sensitivity

  18. Antineoplastic-related cardiotoxicity, morphofunctional aspects in a murine model: contribution of the new tool 2D-speckle tracking

    Directory of Open Access Journals (Sweden)

    Coppola C

    2016-11-01

    Full Text Available Carmela Coppola,1 Gennaro Riccio,1 Antonio Barbieri,2 Maria Gaia Monti,3 Giovanna Piscopo,1 Domenica Rea,2 Claudio Arra,2 Carlo Maurea,1 Claudia De Lorenzo,4,5 Nicola Maurea1 1Division of Cardiology, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”, IRCCS, Naples, Italy; 2Animal Facility Unit, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”, IRCCS, Naples, Italy; 3Department of Translational Medical Sciences, University Federico II, Naples, Italy; 4Department of Molecular Medicine and Medical Biotechnology, University Federico II, Naples, Italy; 5CEINGE Biotecnologie Avanzate, Naples, Italy Objective: Considering that global left ventricular systolic radial strain is a sensitive technique for the early detection of left ventricular dysfunction due to antineoplastics and the analysis of segmental myocardial contractility, we evaluated this technique for early detection of trastuzumab-related cardiotoxicity by comparing it with cardiac structural damage.Methods: Groups of six mice were injected with trastuzumab or doxorubicin, used either as single agents or in combination. Cardiac function was evaluated by transthoracic echocardiography measurements before and after treatment for 2 or 7 days, by using a Vevo 2100 high-resolution imaging system. After echocardiography, mice were euthanized, and hearts were processed for histological evaluations, such as cardiac fibrosis, apoptosis, capillary density, and inflammatory response.Results: Trastuzumab-related cardiotoxicity was detected early by 2D strain imaging. Radial strain was reduced after 2 days in mice treated with trastuzumab alone (21.2%±8.0% vs 40.5%±4.8% sham; P<0.01. Similarly, trastuzumab was found to induce apoptosis, capillary density reduction, and inflammatory response in cardiac tissue after 2 days of treatment, in a fashion similar to doxorubicin. On the contrary, fractional

  19. [The Origin of Scientific Notions in the Circle of the Roman Accademiadella Virt¾ around 1550].

    Science.gov (United States)

    Kulawik, Bernd

    2015-06-01

    The Origin of Scientific Notions in the Circle of the Roman Accademia della Virtù around 1550. Between c. 1537 and 1555 a group of humanists, clerics, architects and philologists known as the so-called Accademia della Virtù got together in Rome to work on a program which was formulated in a letter by the Sienese humanist Claudio Tolomei in 1542 and published in 1547. Starting out with the intention to understand the only surviving antique book on architecture and architectural theory - Vitruvius' De architectura libri decem - the program describes a series of 24 books, eleven containing the classical text and its translation with commentaries, 13 books systematically illustrating and documenting all known and available material remains from Roman antiquity. This program for a scientific classical archaeology in a modern sense was not only intended to serve the intellectual curiosity of some humanist antiquarians but to help architects and their patrons to develop a new architecture of the same high quality as the idealized Roman examples. To achieve this practical as well as theoretical goal it was obviously necessary to re-create the antique vocabulary of architecture and its rules as well as to unify the contemporary usage of notions and norms in a canon. The first results of this project seem to be the In decem Libros M. Vitruvii Pollionis de Architectura Annotationes by Guillaume Philandrier (Rome, 1544) - up to this day a very valuable explanation of ambiguous parts in the Vitruvian text. Until the 1980s, it was believed that this book was the only outcome of the ambitious project; but then two codices of drawings after antique reliefs were identified as preparations for one of the other 23 volumes - and, because of their systematic approach, regarded as the 'first systematic archaeological book'. Now it seems that there are some other corpora of manuscripts and drawings documenting antique artifacts that should be regarded as results of the Accademia's work

  20. Inhalation errors due to device switch in patients with chronic obstructive pulmonary disease and asthma: critical health and economic issues

    Directory of Open Access Journals (Sweden)

    Roggeri A

    2016-03-01

    Full Text Available Alessandro Roggeri,1 Claudio Micheletto,2 Daniela Paola Roggeri1 1ProCure Solutions, Nembro, Bergamo, Italy, 2Respiratory Unit, Mater Salutis Hospital, Legnago, Verona, Italy Background: Different inhalation devices are characterized by different techniques of use. The untrained switching of device in chronic obstructive pulmonary disease (COPD and asthma patients may be associated with inadequate inhalation technique and, consequently, could lead to a reduction in adherence to treatment and limit control of the disease. The aim of this analysis was to estimate the potential economic impact related to errors in inhalation in patients switching device without adequate training. Methods: An Italian real-practice study conducted in patients affected by COPD and asthma has shown an increase in health care resource consumption associated with misuse of inhalers. Particularly, significantly higher rates of hospitalizations, emergency room visits (ER, and pharmacological treatments (steroids and antimicrobials were observed. In this analysis, those differences in resource consumption were monetized considering the Italian National Health Service (INHS perspective. Results: Comparing a hypothetical cohort of 100 COPD patients with at least a critical error in inhalation vs 100 COPD patients without errors in inhalation, a yearly excess of 11.5 hospitalizations, 13 ER visits, 19.5 antimicrobial courses, and 47 corticosteroid courses for the first population were revealed. In the same way, considering 100 asthma patients with at least a critical error in inhalation vs 100 asthma patients without errors in inhalation, the first population is associated with a yearly excess of 19 hospitalizations, 26.5 ER visits, 4.5 antimicrobial courses, and 21.5 corticosteroid courses. These differences in resource consumption could be associated with an increase in health care expenditure for INHS, due to inhalation errors, of €23,444/yr in COPD and €44,104/yr in

  1. The role of health technology assessment bodies in shaping drug development

    Directory of Open Access Journals (Sweden)

    Ciani O

    2014-11-01

    Full Text Available Oriana Ciani,1,3 Claudio Jommi1,2 1Centre for Research on Health and Social Care Management (CERGAS, Bocconi University, Milan, Italy; 2Department of Pharmaceutical Sciences, Università del Piemonte Orientale, Novara, Italy; 3University of Exeter Medical School, Exeter, UK Abstract: The use of health technology assessment (HTA to inform policy-making is established in most developed countries. Compared to licensing agencies, HTA agencies have different interests and, therefore, different evidence requirements. Criteria for coverage or reimbursement decisions on pharmaceutical compounds vary; however, it is common to include, as part of the HTA, a comparative effectiveness evaluation. This type of clinical data might go beyond that required for market authorization, thus creating an additional evidence gap between the regulatory and the reimbursement submission. The relevance of submissions to HTA agencies is consistently increasing in a pharmaceutical company’s perspective, as market prospects are strongly influenced by third-party payers’ coverage. In this study, we aim to describe current HTA activities with a potential impact throughout the drug development process of pharmaceuticals, with a comparative emphasis on the systems in place in Italy and in the UK. Based on an extensive literature and website review, we identified three major classes of HTA activities, beyond mainstream HTA, with the potential to influence the drug development program: 1 horizon scanning and early HTA; 2 bipartite and tripartite early dialogue between manufacturers, regulators, and HTA assessors; and 3 managed market entry agreements. From early stages of clinical research up to postauthorization studies, there is a trend toward increased collaboration between parties, anticipation of market access evidence collection, and postmarketing risk-sharing. Heterogeneity of HTA practices increases the complexity of the market access environment. Overall, there are

  2. Fat-free mass change after nutritional rehabilitation in weight losing COPD: role of insulin, C-reactive protein and tissue hypoxia

    Directory of Open Access Journals (Sweden)

    Simonetta Baldi

    2010-02-01

    Full Text Available Simonetta Baldi, Roberto Aquilani, Gian Domenico Pinna, Paolo Poggi, Angelo De Martini, Claudio BruschiDepartment of Pneumology and Biomedical Engineering, Scientific Institute of Montescano, Salvatore Maugeri Foundation I.R.C.C.S. Pavia, ItalyBackground: Fat-free mass (FFM depletion marks the imbalance between tissue protein synthesis and breakdown in chronic obstructive pulmonary disease (COPD. To date, the role of essential amino acid supplementation (EAAs in FFM repletion has not been fully acknowledged. A pilot study was undertaken in patients attending pulmonary rehabilitation.Methods: 28 COPD patients with dynamic weight loss > 5% over the last 6 months were randomized to receive EAAs embedded in a 12-week rehabilitation program (EAAs group n = 14, or to the same program without supplementation (C group n = 14. Primary outcome measures were changes in body weight and FFM, using dual X-ray absorptiometry (DEXA.Results: At the 12th week, a body weight increment occurred in 92% and 15% of patients in the EAAs and C group, respectively, with an average increase of 3.8 ± 2.6 kg (P = 0.0002 and −0.1 ± 1.1 kg (P = 0.81, respectively. A FFM increment occurred in 69% and 15% of EAAs and C patients, respectively, with an average increase of 1.5 ± 2.6 kg (P = 0.05 and −0.1 ± 2.3 kg (P = 0.94, respectively. In the EAAs group, FFM change was significantly related to fasting insulin (r2 0.68, P < 0.0005, C-reactive protein (C-RP (r2 = 0.46, P < 0.01, and oxygen extraction tension (PaO2x (r2 = 0.46, P < 0.01 at end of treatment. These three variables were highly correlated in both groups (r > 0.7, P < 0.005 in all tests.Conclusions: Changes in FFM promoted by EAAs are related to cellular energy and tissue oxygen availability in depleted COPD. Insulin, C-RP, and PaO2x must be regarded as clinical markers of an amino acid-stimulated signaling to FFM accretion.Keywords: COPD, pulmonary rehabilitation, branched chain amino acids, insulin, systemic

  3. Symptomatic or prophylactic treatment of weekend migraine: an open-label, nonrandomized, comparison study of frovatriptan versus naproxen sodium versus no therapy

    Directory of Open Access Journals (Sweden)

    Guidotti M

    2013-01-01

    Full Text Available Mario Guidotti,1 Caterina Barrilà,1 Serena Leva,1 Claudio De Piazza,1 Stefano Omboni21Department of Neurology, Valduce Hospital, Como, 2Italian Institute of Telemedicine, Varese, ItalyBackground: Migraine often occurs during weekends. The efficacy of frovatriptan, naproxen sodium, or no therapy for the acute or prophylactic treatment of weekend migraineurs was tested in an open-label, nonrandomized pilot study.Methods: Twenty-eight subjects (mean age 36 ± 12 years, including 18 females suffering from migraine without aura were followed up for six consecutive weekends. No treatment was administered during the first two weekends. On the third and fourth weekends, patients were given frovatriptan 2.5 mg and on the fifth and sixth weekends naproxen sodium 500 mg. Treatment was taken on Saturday and Sunday morning, regardless of the occurrence of migraine. Efficacy was evaluated through a diary, where patients reported the severity of migraine on a scale from 0 (no migraine to 10 (severe migraine and use of rescue medication.Results: The migraine severity score was significantly lower with frovatriptan (4.8 [95% confidence interval (CI 3.8–5.9] than with naproxen sodium (5.7 [CI 5.1–6.4], P < 0.05 versus frovatriptan or no therapy (6.6 [6.2–7.0], P < 0.01 versus frovatriptan. The difference in favor of frovatriptan was more striking in patients not taking rescue medication (frovatriptan, 1.9 [1.5–2.3] versus naproxen sodium 3.6 [3.0–4.2], P < 0.001 and versus no therapy (5.1 [4.4–5.8], P < 0.001 and on the second day of treatment. The rate of use of rescue medication was significantly (P < 0.05 lower on frovatriptan (12.5% than on naproxen sodium (31.3% or no therapy (56.3%.Conclusion: This pilot study provides the first evidence of the efficacy of a second-generation triptan as symptomatic or prophylactic treatment for weekend migraine.Keywords: migraine, frovatriptan, naproxen sodium, weekend

  4. Campo Belo Metamorphic Complex: tectonic evolution of an Archean sialic crust of the southern São Francisco Craton in Minas Gerais (Brazil

    Directory of Open Access Journals (Sweden)

    ARILDO H. OLIVEIRA

    2001-09-01

    Full Text Available Systematic geological studies performed in the study area allowed the characterization of six lithodemic units: three gneissic, one amphibolitic, one supracrustal and one fissure mafic. The mineral assemblage and the structural record of these lithodemic units indicate that the study area was affected by five tectonothermal events. The structural pattern of the first and oldest event occurred under granulite facies conditions and reveals essentially a sinistral kinematic pattern. The second event, showing dominant extensional characteristics, is related to the generation of an ensialic basin filled by the volcano-sedimentary sequence of the supracrustal lithodemic unit. The third event, which is the most expressive in the study region, is characterized by a vigorous regional migmatization process and by the generation of the Claudio Shear Zone, presenting dextral kinematic movement. The fourth event is represented by a fissure mafic magmatism (probably two different mafic dike swarms and finally, the fifth event is a regional metamorphic re-equilibration that reached the greenschist facies, closing the main processes of the tectonic evolution of the Campo Belo Metamorphic Complex.Estudos geológicos sistemáticos permitiram a caracterização de seis unidades litodêmicas na área estudada: três gnáissicas, uma anfibolítica, uma supracrustal e uma máfica fissural. A assembléia mineral e os registros estruturais dessas unidades litodêmicas mostraram que a área estudada foi afetada por cinco eventos tectonotermais. O padrão estrutural do primeiro e último evento ocorreu em condições de fácies granulito e revelaram uma cinemática essencialmente sinistral. O segundo evento mostrou uma tectônica extensional relacionado à abertura da bacia ensiálica onde se alojou a seqüência vulcanosedimentar da unidade supracrustal. O terceiro evento, que é o mais expressivo na região estudada, é o responsável por um intenso processo de

  5. The complex of PAMAM-OH dendrimer with Angiotensin (1–7 prevented the disuse-induced skeletal muscle atrophy in mice

    Directory of Open Access Journals (Sweden)

    Márquez-Miranda V

    2017-03-01

    Full Text Available Valeria Márquez-Miranda,1,2,* Johanna Abrigo,3,4,* Juan Carlos Rivera,3,4 Ingrid Araya-Durán,1 Javier Aravena,3,4 Felipe Simon,3,4 Nicolás Pacheco,1 Fernando Danilo González-Nilo,1,2,5 Claudio Cabello-Verrugio3,4 1Center for Bioinformatics and Integrative Biology (CBIB, Facultad de Ciencias Biologicas, Universidad Andres Bello, Santiago, 2Fundación Fraunhofer Chile Research, Las Condes, 3Departamento de Ciencias Biologicas, Facultad de Ciencias Biologicas & Facultad de Medicina, Universidad Andres Bello, 4Millennium Institute on Immunology and Immunotherapy, Santiago, 5Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile *These authors contributed equally to this work Abstract: Angiotensin (1–7 (Ang-(1–7 is a bioactive heptapeptide with a short half-life and has beneficial effects in several tissues – among them, skeletal muscle – by preventing muscle atrophy. Dendrimers are promising vehicles for the protection and transport of numerous bioactive molecules. This work explored the use of a neutral, non-cytotoxic hydroxyl-terminated poly(amidoamine (PAMAM-OH dendrimer as an Ang-(1–7 carrier. Bioinformatics analysis showed that the Ang-(1–7-binding capacity of the dendrimer presented a 2:1 molar ratio. Molecular dynamics simulation analysis revealed the capacity of neutral PAMAM-OH to protect Ang-(1–7 and form stable complexes. The peptide coverage ability of the dendrimer was between ~50% and 65%. Furthermore, an electrophoretic mobility shift assay demonstrated that neutral PAMAM-OH effectively bonded peptides. Experimental results showed that the Ang-(1–7/PAMAM-OH complex, but not Ang-(1–7 alone, had an anti-atrophic effect when administered intraperitoneally, as evaluated by muscle strength, fiber diameter, myofibrillar protein levels, and atrogin-1 and MuRF-1 expressions. The results of the Ang-(1–7/PAMAM-OH complex being intraperitoneally

  6. Quantum Structure of Space and Time

    Science.gov (United States)

    Duff, M. J.; Isham, C. J.

    2012-07-01

    Foreword Abdus Salam; Preface; List of participants; Part I. Quantum Gravity, Fields and Topology: 1. Some remarks on gravity and quantum mechanics Roger Penrose; 2. An experimental test of quantum gravity Don N. Page and C. D. Geilker; 3. Quantum mechanical origin of the sandwich theorem in classical gravitation theory Claudio Teitelboim; 4. θ-States induced by the diffeomorphism group in canonically quantized gravity C. J. Isham; 5. Strong coupling quantum gravity: an introduction Martin Pilati; 6. Quantizing fourth order gravity theories S. M. Christensen; 7. Green's functions, states and renormalisation M. R. Brown and A. C. Ottewill; 8. Introduction to quantum regge calculus Martin Roček and Ruth Williams; 9. Spontaneous symmetry breaking in curved space-time D. J. Toms; 10. Spontaneous symmetry breaking near a black hole M. S. Fawcett and B. F. Whiting; 11. Yang-Mills vacua in a general three-space G. Kunstatter; 12. Fermion fractionization in physics R. Jackiw; Part II. Supergravity: 13. The new minimal formulation of N=1 supergravity and its tensor calculus M. F. Sohnius and P. C. West; 14. A new deteriorated energy-momentum tensor M. J. Duff and P. K. Townsend; 15. Off-shell N=2 and N=4 supergravity in five dimensions P. Howe; 16. Supergravity in high dimensions P. van Niewenhuizen; 17. Building linearised extended supergravities J. G. Taylor; 18. (Super)gravity in the complex angular momentum plane M. T. Grisaru; 19. The multiplet structure of solitons in the O(2) supergravity theory G. W. Gibbons; 20. Ultra-violet properties of supersymmetric gauge theory S. Ferrara; 21. Extended supercurrents and the ultra-violet finiteness of N=4 supersymmetric Yang-Mills theories K. S. Stelle; 22. Duality rotations B. Zumino; Part III. Cosmology and the Early Universe: 23. Energy, stability and cosmological constant S. Deser; 24. Phase transitions in the early universe T. W. B. Kibble; 25. Complete cosmological theories L. P. Grishchuk and Ya. B. Zeldovich; 26. The

  7. Pregnancy is associated with psychiatric symptoms in a low-income countryside community of Brazil

    Directory of Open Access Journals (Sweden)

    Dias FMV

    2011-11-01

    Full Text Available Fernando MV Dias1–3, Claudio SD Junior4, Glaura C Franco5, Antônio L Teixeira3, Angela M Ribeiro21Department of Medicine and Nursing, Federal University of Viçosa, Viçosa; 2Graduate Program in Neurosciences, Laboratory of Molecular and Behavioral Neuroscience (LaNeC; 3Graduate Program in Neurosciences, Neuropsychiatric Branch Research; 4Department of Sociology and Anthropology; 5Department of Statistics, Federal University of Minas Gerais, Belo Horrizonte, BrazilBackground: Psychiatric symptoms during pregnancy induce an increase in morbidity and also in the mortality levels among women and children. However, the real association between pregnancy and psychiatric disorders and the peculiarities of the phenomenology of symptoms in underprivileged countryside communities remain uncertain.Objective: To verify the association between psychiatric disorder, symptoms, and pregnancy among women from a low-income countryside community and to determine the specific cutoff points for major depression diagnosis according to Beck Depression Inventory for the different trimesters of pregnancy in this population.Methods: Ninety-four pregnant women and 38 healthy women from the Conceição do Mato Dentro health service, a rural low-income community in Brazil, participated in the present study. Psychiatric examination included a structured clinical interview for psychiatric disorders according to Mini International Neuropsychiatric Interview and psychometric scales such as the Yale–Brown Obsessive Scale, the Beck Depression Inventory, and the Hamilton Anxiety Scale. The cutoff points for Beck Depression Inventory were determined through the application of receiver operating characteristic curves considering the diagnosis of major depression according to Mini International Neuropsychiatric Interview.Results: The pregnant women had a higher frequency of psychiatric disorders and depression and anxiety symptoms. All cutoff points of Beck Depression Inventory

  8. Apariencia y realidad en Hamlet y Las Meninas

    Directory of Open Access Journals (Sweden)

    Antonio PRIETO MARTÍNEZ

    2009-11-01

    Full Text Available La obra de Shakespeare comenzó a ser estudiada en profundidad a finales del siglo XVII y, sobre todo, en el siglo XVIII. Desde ese siglo hasta el momento actual la investigación en torno a la obra shakesperiana se ha desarrollado hasta tal punto que resulta inabordable. De entre la obra de Shakespeare, Hamlet es probablemente la que suscita mayor interés a causa de su compleja estructura y su contenido ambiguo. Del mismo modo, la obra de Velázquez comenzó a estudiarse con rigor en el siglo XVIII, aunque hasta el siglo XX no se investigan sus características e influencias. Como en el caso de Shakespeare, la bibliografía existente en la actualidad sobre su obra resulta inaccesible para el investigador. De entre todas sus pinturas, Las Meninas, del mismo modo que Hamlet, es la que despierta mayor interés y tiene una proyección universal. Haciendo un recorrido por las investigaciones más importantes realizadas sobre ambas obras en los tres últimos siglos, intento encontrar semejanzas entre ellas, basándome fundamentalmente en su estructura. Apoyando mi investigación en la teoría deconstructivista, según la propuesta de J. Derrida, y siguiendo el esquema formal de ambas obras, propongo el tema general de apariencia y realidad como núcleo de sus semejanzas. Los puntos de analogía entre Hamlet y Las Meninas son, en síntesis, los siguientes: - Texto (expresado en el ser o no ser y el reverso del lienzo sobre el que pinta Velázquez. - El personaje del espectro en Hamlet y el personaje invisible en el cuadro (María Teresa de Austria o el espectador. - Velázquez significante representado en el cuadro y la obra dentro de la obra que representan los cómicos. - El personaje de Claudio, como símbolo del tirano y los reyes representados en el espejo. - Finalmente considero la vigencia y proyección que tienen ambas obras en el mundo actual.

  9. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2008-12-01

    Full Text Available Christoph Antons (ed.; Law and development in East and South-East Asia (Adriaan Bedner David B. Dewitt, Carolina G. Hernandez (eds; Development and security in Southeast Asia (vol. 1 & 2 (Freek Colombijn Lily Kong, Brenda S.A. Yeoh; The politics of landscape in Singapore; Constructions of ‘nation’ (Ben Derudder Andrew Hardy; Red hills; Migrants and the state in the highlands of Vietnam (Hans Hägerdal Hanneman Samuel, Henk Schulte Nordholt (eds; Indonesia in transition; Rethinking ‘civil society’, ‘region’, and ‘crisis’ (david Henley S. Margana; Pujangga Jawa dan bayang-bayang kolonial (Mason Hoadley Karel E.M. Bongenaar; De ontwikkeling van het zelfbesturend landschap in Nederlandsch-Indie: 1855-1942 (Gerry van Klinken Pamela J. Stewart, Andrew Strathern; Humors and substances; Ideas of the body in New Guinea (Michael Lieber Wu Xiao An; Chinese business in the making of a Malay state, 1882-1941 (Loh Wei Leng Mikihiro Moriyama; Sundanese print culture and modernity in 19th-century West Java (Julian Millie Yunita T. Winarto; Seeds of knowledge; The beginning of integrated pest management in Java (Simon Platten Jelle Miedema, Ger Reesink; One head, many faces; New perspectives on the Bird’s Head Peninsula of New Guinea (Anton Ploeg Christopher R. Duncan (ed.; Civilizing the margins; Southeast Asian government policies for the development of minorities (Nathan Porath Rosario Mendoza Cortes, Celestina Puyal Boncan, Ricardo Trota Jose; The Filipino saga; History as social change (Portia L. Reyes Stephen Dobbs; The Singapore River; A social history, 1819-2002 (Victor R. Savage Michael Wood; Official history in modern Indonesia; New Order perceptions and counterviews (Henk Schulte Nordholt Claudio O. Delang (ed.; Living at the edge of Thai society; The Karen in the highlands of northern Thailand (Nicholas Tapp Andrew C. Willford, Kenneth M. George (eds; Spirited politics: Religion

  10. A cost-effectiveness evaluation comparing originator follitropin alfa to the biosimilar for the treatment of infertility

    Directory of Open Access Journals (Sweden)

    Gizzo S

    2016-12-01

    Full Text Available Salvatore Gizzo,1 Juan A Garcia-Velasco,2 Franca Heiman,3 Claudio Ripellino,3 Klaus Bühler4 1Department of Woman and Child Health, University of Padua, Padua, Italy; 2Department of Obstetrics and Gynecology, Rey Juan Carlos University Madrid, Madrid, Spain; 3IMS Health Information Solutions Italy Srl, Milan, Italy; 4Centre for Gynaecology, Endocrinology, and Reproductive Medicine, Ulm and Stuttgart, Germany Objectives: To perform a cost-effectiveness evaluation comparing the originator follitropin alfa (Gonal-f® to the biosimilar (Bemfola® in the Italian and Spanish contexts, with an assessment of the German and UK backgrounds. Methods: Starting from the study by Rettenbacher et al, a cost-effectiveness model was developed in the Italian and Spanish contexts. Clinical data on subjects, doses of gonadotropin, pregnancies, live-born children, and ovarian hyperstimulation syndrome were used to feed the model. Costs related to drugs, hospitalizations, specialist visits, and examinations were retrieved from Italian and Spanish tariffs. Gonadotropin acquisition costs for Germany and the UK were also taken into account to expand the economical assessment to the other countries. The evaluation was done based on the National Health Service perspective. Sensitivity analyses, both univariate and probabilistic, as long as scenario analyses, tested the robustness of the model. Results: Originator follicle-stimulating hormone (FSH costs were €3,663 and €6,387 in Italy and Spain, respectively, whereas biosimilar FSH costs were €3,483 and €6,342. The efficacy was found to be 0.52 for the originator and 0.47 for the biosimilar. The average cost per live birth was estimated to be €7,044 and €12,283 for the originator FSH and €7,411 and €13,494 for the biosimilar for Italy and Spain, respectively. Furthermore, the originator FSH generated an incremental cost-effectiveness ratio of €3,600 for Italy and €900 for Spain compared to the

  11. Low-dose modified-release prednisone in axial spondyloarthritis: 3-month efficacy and tolerability

    Directory of Open Access Journals (Sweden)

    Bandinelli F

    2016-11-01

    Full Text Available Francesca Bandinelli,1 Francesco Scazzariello,1 Emanuela Pimenta da Fonseca,2 Mittermayer Barreto Santiago,2 Claudio Marcassa,3 Francesca Nacci,1 Marco Matucci Cerinic1 1Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; 2Service of Rheumatology, Hospital Santa Isabel, Escola de Medicina e Saúde Pública, Bahia, Brazil; 3Maugeri Clinical and Scientific Institutes, IRCCS, Veruno, Novara, Italy Background: Oral glucocorticoids (GCs have been shown to be effective in reducing the inflammatory symptoms of rheumatoid arthritis, but their use is not supported by evidence in spondyloarthritis (SpA. Modified-release (MR oral prednisone taken at bedtime has been shown to be more effective than immediate-release prednisone taken in the morning. The efficacy of low-dose MR prednisolone in patients with SpA is unknown. Patients and methods: This single-center cohort study retrospectively assessed the effectiveness and safety of 12-week low-dose MR prednisone (5 mg daily, bedtime administration in GC-naïve adult patients with symptomatic axial SpA. A 50% improvement of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI or a final BASDAI score of <4 according to disease activity at baseline was chosen as the primary outcome parameter after MR prednisone. Results: Fifty-seven patients were evaluated; of them, 41 had an active disease (BASDAI score of ≥4 at baseline. MR prednisone significantly reduced BASDAI (from 5.5±2.6 to 3.0±2.8, P<0.001 as well as inflammatory symptoms, pain, fatigue and morning stiffness. The overall response rate after MR prednisone was 52.6% (53.7% in patients with active SpA and 50.0% in patients with low-active disease; nonsignificant. At multivariable analysis, none of the considered clinical findings independently predicted the response to MR prednisone in subjects with active SpA. Overall, seven patients (11.8% had nonserious adverse drug reactions after MR prednisone

  12. Targeted tumor imaging of anti-CD20-polymeric nanoparticles developed for the diagnosis of B-cell malignancies

    Directory of Open Access Journals (Sweden)

    Capolla S

    2015-06-01

    Full Text Available Sara Capolla,1 Chiara Garrovo,2 Sonia Zorzet,1 Andrea Lorenzon,3 Enrico Rampazzo,4 Ruben Spretz,5 Gabriele Pozzato,6 Luis Núñez,7 Claudio Tripodo,8 Paolo Macor,1,9 Stefania Biffi2 1Department of Life Sciences, University of Trieste, 2Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, Trieste, 3Animal Care Unit, Cluster in Biomedicine (CBM scrl, Trieste, Italy; 4Department of Chemistry “G. Ciamician”, University of Bologna, Bologna, Italy; 5LNK Chemsolutions LLC, Lincoln, NE, USA; 6Department of Medical, Surgery and Health Sciences, University of Trieste, Trieste, Italy; 7Bio-Target, Inc., University of Chicago, Chicago, IL, USA; 8Department of Human Pathology, University of Palermo, Palermo, Italy; 9Callerio Foundation Onlus, Institutes of Biological Researches, Trieste, Italy Abstract: The expectations of nanoparticle (NP-based targeted drug delivery systems in cancer, when compared with convectional therapeutic methods, are greater efficacy and reduced drug side effects due to specific cellular-level interactions. However, there are conflicting literature reports on enhanced tumor accumulation of targeted NPs, which is essential for translating their applications as improved drug-delivery systems and contrast agents in cancer imaging. In this study, we characterized biodegradable NPs conjugated with an anti-CD20 antibody for in vivo imaging and drug delivery onto tumor cells. NPs’ binding specificity mediated by anti-CD20 antibody was evaluated on MEC1 cells and chronic lymphocytic leukemia patients’ cells. The whole-body distribution of untargeted NPs and anti-CD20 NPs were compared by time-domain optical imaging in a localized human/mouse model of B-cell malignancy. These studies provided evidence that NPs’ functionalization by an anti-CD20 antibody improves tumor pharmacokinetic profiles in vivo after systemic administration and increases in vivo imaging of tumor mass compared to non-targeted NPs. Together

  13. The effect of vagal nerve blockade using electrical impulses on glucose metabolism in nondiabetic subjects

    Directory of Open Access Journals (Sweden)

    Sathananthan M

    2014-07-01

    Full Text Available Matheni Sathananthan,1 Sayeed Ikramuddin,2 James M Swain,3,6 Meera Shah,1 Francesca Piccinini,4 Chiara Dalla Man,4 Claudio Cobelli,4 Robert A Rizza,1 Michael Camilleri,5 Adrian Vella1 1Division of Endocrinology, Diabetes and Metabolism, Mayo Clinic College of Medicine, Rochester, MN, USA; 2Division of General Surgery, University of Minnesota, Minneapolis, MN, USA; 3Division of General Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA; 4Department of Information Engineering, University of Padua, Padua, Italy; 5Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN, USA; 6Scottsdale Healthcare Bariatric Center, Scottsdale, AZ, USA Purpose: Vagal interruption causes weight loss in humans and decreases endogenous glucose production in animals. However, it is unknown if this is due to a direct effect on glucose metabolism. We sought to determine if vagal blockade using electrical impulses alters glucose metabolism in humans. Patients and methods: We utilized a randomized, cross-over study design where participants were studied after 2 weeks of activation or inactivation of vagal nerve blockade (VNB. Seven obese subjects with impaired fasting glucose previously enrolled in a long-term study to examine the effect of VNB on weight took part. We used a standardized triple-tracer mixed meal to enable measurement of the rate of meal appearance, endogenous glucose production, and glucose disappearance. The 550 kcal meal was also labeled with 111In-diethylene triamine pentaacetic acid (DTPA to measure gastrointestinal transit. Insulin action and ß-cell responsivity indices were estimated using the minimal model. Results: Integrated glucose, insulin, and glucagon concentrations did not differ between study days. This was also reflected in a lack of effect on β-cell responsivity and insulin action. Furthermore, fasting and postprandial endogenous glucose production, integrated meal appearance, and glucose

  14. Analgesic effectiveness and tolerability of oral oxycodone/naloxone and pregabalin in patients with lung cancer and neuropathic pain: an observational analysis

    Directory of Open Access Journals (Sweden)

    De Santis S

    2016-07-01

    Full Text Available Stefano De Santis,1 Cristina Borghesi,1 Serena Ricciardi,2 Daniele Giovannoni,1 Alberto Fulvi,2 Maria Rita Migliorino,2 Claudio Marcassa3 1Palliative Care and Cancer Pain Service, Oncological Pulmonary Unit, 2Oncological Pulmonary Unit, San Camillo-Forlanini Hospitals, Rome, 3Cardiologia Fondazione Maugeri IRCCS, Novara, Italy Introduction: Cancer-related pain has a severe negative impact on quality of life. Combination analgesic therapy with oxycodone and pregabalin is effective for treating neuropathic cancer pain. We investigated the efficacy and tolerability of a dose-escalation combination therapy with prolonged-release oxycodone/naloxone (OXN-PR and pregabalin in patients with non-small-cell lung cancer and severe neuropathic pain. Methods: This was a 4-week, open-label, observational study. Patients were treated with OXN-PR and pregabalin. Average pain intensity ([API] measured on a 0–10 numerical rating scale and neuropathic pain (Douleur Neuropathique 4 were assessed at study entry and at follow-up visits. The primary endpoint was response to treatment, defined as a reduction of API at T28 ≥30% from baseline. Secondary endpoints included other efficacy measures, as well as patient satisfaction and quality of life (Brief Pain Inventory Short Form, Hospital Anxiety and Depression Scale, and Symptom Distress Scale; bowel function was also assessed. Results: A total of 56 patients were enrolled. API at baseline was 8.0±0.9, and decreased after 4 weeks by 48% (4.2±1.9; P<0.0001 vs baseline; 46 (82.1% patients responded to treatment. Significant improvements were also reported in number/severity of breakthrough cancer pain episodes (P=0.001, Brief Pain Inventory Short Form (P=0.0002, Symptom Distress Scale (P<0.0001, Hospital Anxiety and Depression Scale depression (P=0.0006 and anxiety (P<0.0001 subscales, and bowel function (P=0.0003. At study end, 37 (66.0% patients were satisfied/very satisfied with the new analgesic treatment

  15. Heart rate response during a simulated Olympic boxing match is predominantly above ventilatory threshold 2: a cross sectional study

    Directory of Open Access Journals (Sweden)

    de Lira CA

    2013-07-01

    Full Text Available Claudio Andre Barbosa de Lira,1 Luiz Fernando Peixinho-Pena,2 Rodrigo Luiz Vancini1,2 Rafael Júlio de Freitas Guina Fachina,3,4 Alexandre Aparecido de Almeida,2 Marília dos Santos Andrade,2 Antonio Carlos da Silva2 1Setor de Fisiologia Humana e do Exercício, Universidade Federal de Goiás (UFG, Câmpus Jataí, Jataí, GO, Brazil; 2Departamento de Fisiologia, Universidade Federal de São Paulo (UNIFESP, São Paulo, SP, Brazil; 3Departamento de Ciência do Esporte, Faculdade de Educação Física (FEF, Universidade Estadual de Campinas (UNICAMP, Campinas, Brazil; 4Confederação Brasileira de Basketball (CBB, Rio de Janeiro, Brazil Abstract: The present study aimed to describe heart rate (HR responses during a simulated Olympic boxing match and examine physiological parameters of boxing athletes. Ten highly trained Olympic boxing athletes (six men and four women performed a maximal graded exercise test on a motorized treadmill to determine maximal oxygen uptake (52.2 mL · kg-1 · min-1 ± 7.2 mL · kg-1 · min-1 and ventilatory thresholds 1 and 2. Ventilatory thresholds 1 and 2 were used to classify the intensity of exercise based on respective HR during a boxing match. In addition, oxygen uptake (VO2 was estimated during the match based on the HR response and the HR-VO2 relationship obtained from a maximal graded exercise test for each participant. On a separate day, participants performed a boxing match lasting three rounds, 2 minutes each, with a 1-minute recovery period between each round, during which HR was measured. In this context, HR and VO2 were above ventilatory threshold 2 during 219.8 seconds ± 67.4 seconds. There was an increase in HR and VO2 as a function of round (round 3 < round 2 < round 1, P < 0.0001.These findings may direct individual training programs for boxing practitioners and other athletes. Keywords: heart rate, physiological profile, intermittent exercise, combat sports, boxing

  16. Ultra-scale Visualization Climate Data Analysis Tools (UV-CDAT)

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Dean N. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2011-07-20

    This report summarizes work carried out by the Ultra-scale Visualization Climate Data Analysis Tools (UV-CDAT) Team for the period of January 1, 2011 through June 30, 2011. It discusses highlights, overall progress, period goals, and collaborations and lists papers and presentations. To learn more about our project, please visit our UV-CDAT website (URL: http://uv-cdat.org). This report will be forwarded to the program manager for the Department of Energy (DOE) Office of Biological and Environmental Research (BER), national and international collaborators and stakeholders, and to researchers working on a wide range of other climate model, reanalysis, and observation evaluation activities. The UV-CDAT executive committee consists of Dean N. Williams of Lawrence Livermore National Laboratory (LLNL); Dave Bader and Galen Shipman of Oak Ridge National Laboratory (ORNL); Phil Jones and James Ahrens of Los Alamos National Laboratory (LANL), Claudio Silva of Polytechnic Institute of New York University (NYU-Poly); and Berk Geveci of Kitware, Inc. The UV-CDAT team consists of researchers and scientists with diverse domain knowledge whose home institutions also include the National Aeronautics and Space Administration (NASA) and the University of Utah. All work is accomplished under DOE open-source guidelines and in close collaboration with the project's stakeholders, domain researchers, and scientists. Working directly with BER climate science analysis projects, this consortium will develop and deploy data and computational resources useful to a wide variety of stakeholders, including scientists, policymakers, and the general public. Members of this consortium already collaborate with other institutions and universities in researching data discovery, management, visualization, workflow analysis, and provenance. The UV-CDAT team will address the following high-level visualization requirements: (1) Alternative parallel streaming statistics and analysis pipelines - Data

  17. Central airways remodeling in COPD patients

    Directory of Open Access Journals (Sweden)

    Pini L

    2014-09-01

    Full Text Available Laura Pini,1 Valentina Pinelli,2 Denise Modina,1 Michela Bezzi,3 Laura Tiberio,4 Claudio Tantucci1 1Unit of Respiratory Medicine, Department of Clinical and Experimental Sciences, University of Brescia, 2Department of Respiratory Medicine, Spedali Civili di Brescia, 3Department Bronchoscopy, Spedali Civili di Brescia, 4Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy Background: The contribution to airflow obstruction by the remodeling of the peripheral airways in chronic obstructive pulmonary disease (COPD patients has been well documented, but less is known about the role played by the large airways. Few studies have investigated the presence of histopathological changes due to remodeling in the large airways of COPD patients. Objectives: The aim of this study was to verify the presence of airway remodeling in the central airways of COPD patients, quantifying the airway smooth muscle (ASM area and the extracellular matrix (ECM protein deposition, both in the subepithelial region and in the ASM, and to verify the possible contribution to airflow obstruction by the above mentioned histopathological changes. Methods: Biopsies of segmental bronchi spurs were performed in COPD patients and control smoker subjects and immunostained for collagen type I, versican, decorin, biglycan, and alpha-smooth muscle actin. ECM protein deposition was measured at both subepithelial, and ASM layers. Results: The staining for collagen I and versican was greater in the subepithelial layer of COPD patients than in control subjects. An inverse correlation was found between collagen I in the subepithelial layer and both forced expiratory volume in 1 second and ratio between forced expiratory volume in 1 second and forced vital capacity. A statistically significant increase of the ASM area was observed in the central airways of COPD patients versus controls. Conclusion: These findings indicate that airway remodeling also affects

  18. El espejismo nacional-socialista. La relación entre dos catedráticos de Prehistoria, Oswald Menghin y Julio Martínez Santa-Olalla (1935-1952

    Directory of Open Access Journals (Sweden)

    Mederos Martín, Alfredo

    2014-12-01

    , Claudio Sanchez-Albornoz. Menghin was not permitted to give lectures until 1953, and only consolidated his position when his criminal trial was cancelled in December 1956. In 1957 at the age of 69, he obtained the position of Acting Professor of Prehistory at the National University of La Plata. In 1958, Menghin was appointed Professor in General and Old World Prehistory at the University of Buenos Aires, where he retired in 1968, aged 80.Oswald Menghin, Catedrático de Prehistoria del Hombre de la Universidad de Viena entre 1922-1945, fue partidario de la unidad de Austria con Alemania y simpatizante con ideas del NSDAP sobre la necesidad de evitar una mezcla racial entre arios y judíos. Durante su etapa como Catedrático-Residente en la Universidad de Fouad en El Cairo entre 1930-1933, por contacto con Hermann Junker, radicalizó sus puntos de vista y redactó su libro Espíritu y sangre. Principios básicos de raza, lengua, cultura y nación. Su etapa como Rector en el curso 1935-1936 le catapultó a la política como miembro del consejo directivo del partido fascista austriaco, Vaterländische Front, entre 1936-1937 y su posterior nombramiento como Ministro de Educación entre marzo y mayo de 1938, justo después de la invasión de Hitler de Austria. Siendo Ministro, solicitó su ingreso en el NSDAP, que no se aceptó hasta junio de 1940, por su pertenencia previa a organizaciones católicas secretas. Menghin entró en contacto con Martínez Santa-Olalla, después de la celebración del Jubileo del Instituto de Morfología Cultural de Frankfurt en junio y julio de 1938. A raíz de una estancia de investigación de Almagro Basch en Alemania y Austria en enero y febrero de 1942, y la posterior visita a Barcelona de Menghin en junio de 1942, optó por distanciarse de Martínez Santa-Olalla, no visitando Madrid, cortando la relación epistolar e informando negativamente sobre él a las SS-Ahnenerbe. Prisionero en dos campos de concentración norteamericanos entre mayo de

  19. Atuação fonoaudiológica na síndrome da apnéia e hipopnéia obstrutiva do sono: relato de caso Speech therapy in the obstructive sleep apnea-hypopnea syndrome: case report

    Directory of Open Access Journals (Sweden)

    Letícia Maria de Paula Silva

    2007-12-01

    Full Text Available OBJETIVO: verificar a contribuição da Fonoaudiologia no tratamento de uma paciente com a síndrome da apnéia e hipopnéia obstrutiva do sono. MÉTODOS: relato de caso de um paciente do sexo feminino, de sessenta anos de idade, com a síndrome da apnéia e hipopnéia do sono, de grau grave, que se submeteu ao atendimento fonoaudiológico para melhora do quadro de apnéia/hipopnéia, ronco e cansaço diurno. Foram realizadas avaliação clínica de motricidade orofacial e polissonografia antes e após a fonoterapia. Com base na avaliação clínica foi elaborado um plano terapêutico que buscou propiciar à paciente relaxamento cervical e da musculatura supra-hióidea, melhora na aeração nasal, adequação do posicionamento e força de língua, fortalecimento dos músculos do palato mole e sua mobilidade, aumento de força da musculatura mastigatória, treino da mastigação bilateral alternada e abaixamento do osso hióide. RESULTADOS: após 12 sessões de terapia fonoaudiológica, com duração de 40 minutos cada, pôde-se observar diminuição da tensão cervical, relaxamento da musculatura supra-hióidea, adequação do posicionamento do osso hióide, língua normotensa com dorso rebaixado, palato mole com mobilidade normal e mastigação adequada. A paciente relatou importante melhora no cansaço diurno. O resultado da segunda polissonografia indicou diminuição de 44 para 3 eventos por hora de apnéia e hipopnéia durante o sono, tendo o quadro passado do nível grave a um índice de distúrbio respiratório baixo não mais caracterizando doença apnéica do sono. CONCLUSÃO: a fonoterapia foi eficaz para o tratamento deste caso de síndrome da apnéia e hipopnéia do sono.Purpose: to check the contribution of speech therapy in the treatment of a patient with obstructive sleep apnea-hypopnea syndrome. METHODS: case description of a sixty-year old, female patient with severe obstructive sleep apnea-hypopnea syndrome that underwent

  20. Respiração oral na criança: repercussões diferentes de acordo com o diagnóstico Mouth breathing in children: different repercussions according to the diagnosis

    Directory of Open Access Journals (Sweden)

    Renata C. Di Francesco

    2004-10-01

    Full Text Available A respiração oral é um sintoma freqüente na infância. A síndrome do respirador oral caracteriza-se por cansaço freqüente, sonolência diurna, adinamia, baixo apetite, enurese noturna e até déficit de aprendizado e atenção. Entretanto este sintoma apresenta diversas causas. Faz-se necessário, portanto, esclarecer detalhes sobre estes aspectos clínicos de acordo com suas causas. OBJETIVO: Comparar os achados de sonolência diurna, cefaléia, agitação noturna, enurese, problemas escolares e bruxismo em indivíduos com respiração oral; de acordo com os seguintes diagnósticos: rinite alérgica, hiperplasia adenoideana, hiperplasia adenoamigdaliana. FORMA DE ESTUDO: Estudo de coorte transversal. MATERIAL E MÉTODO: Estudo prospectivo com 142 pacientes de 2 a 16 anos, classificados em três grupos: rinite alérgica, hiperplasia adenoideana isolada e hiperplasia adenoamigdaliana. Os responsáveis dos pacientes responderam a questionário padronizado sobre os sintomas noturnos para caracterização da presença de apnéia do sono e sobre os aspectos estudados: cefaléia matinal, desempenho escolar e atenção, sonolência diurna, agitação noturna, enurese, bruxismo. RESULTADOS: A respiração oral é mais freqüente em meninos. Crianças com hiperplasia adenoamigdaliana são mais jovens. Este grupo apresenta maior freqüência de roncos e apnéia do sono, assim como mau desempenho escolar, bruxismo, enurese e agitação noturna, sendo estes sintomas relacionados com a apnéia, diferenciando-se do grupo com rinite alérgica. Não se observou sonolência diurna e cefaléia matinal significante nos grupos estudados. CONCLUSÃO: Bruxismo, enurese, agitação noturna e cefaléia estão relacionados com a apnéia do sono, sendo mais freqüente na hiperplasia adenoamigdaliana. Assim, a investigação de apnéia do sono na criança com respiração oral é fundamental e assim como a determinação da causa da respiração oral

  1. Diffuse panbronchiolitis: an underdiagnosed disease? Study of 4 cases in Brazil Panbronquiolite difusa: uma doença subdiagnosticada? Estudo de quatro casos no Brasil

    Directory of Open Access Journals (Sweden)

    Rogério Souza

    2002-08-01

    , nos quais a suspeita diagnóstica se baseou nos aspectos clínicos e radiológicos e foi confirmada através da biópsia transbrônquica. As principais características clínicas eram sinusite crônica, tosse produtiva, além da presença de roncos e sibilos. Os testes de função pulmonar evidenciaram um padrão obstrutivo. A tomografia de tórax de alta resolução demonstrou um padrão nodular difuso, além de ectasia e espessamento das paredes das vias aéreas. O exame histológico evidenciou acúmulo intersticial de macrófagos xantomatosos e infiltração de linfócitos na região dos bronquíolos respiratórios, sendo que 2 de nossos casos ainda apresentaram hiperplasia de tecido linfocitário associado aos brônquios. Investigamos a presença do HLA Bw54 nos quatro casos, sendo apenas um positivo. Após o diagnóstico, instituiu-se o tratamento com macrolídeos em dose baixa, tendo como resultado melhora clínica e funcional. Um escore que avalia a extensão do padrão nodular, a ectasia e o espessamento das vias aéreas e ainda o grau de impactação mucóide visíveis à tomografia foi utilizado pré e pós tratamento evidenciando uma melhora compatível com a observada à função pulmonar. CONCLUSÃO: Concluímos que a Panbronquiolite Difusa é uma doença sistêmica, não exclusiva da população oriental, cujas características clínicas e radiológicas devem ser melhor conhecidas pelos médicos ocidentais.

  2. Achados polissonográficos em crianças portadoras de laringopatias Polisomnographic findings on children with laryngopathies

    Directory of Open Access Journals (Sweden)

    Michele Themis Moraes Gonçalves

    2006-04-01

    Full Text Available O exame diagnóstico padrão-ouro para SAOS na infância é a polissonografia. Quando pode ser efetuado, a polissonografia separa com clareza portadores de ronco primário de pacientes com apnéia (obstrutiva, central e mista do sono. A causa mais freqüente da SAOS na infância é a hipertrofia adenoamigdaliana. Laringomalácia é a causa mais comum de estridor na infância, porém sua fisiopatologia permanece desconhecida. Entre as teorias mais aceitas estão a imaturidade do arcabouço cartilaginoso da laringe e/ou a imaturidade neuromuscular. OBJETIVO: Nossa proposta foi descrever os achados polissonográficos de crianças portadoras de laringomalácia e outras alterações laríngeas isoladas, ou seja, sem alterações nas vias aéreas superiores. MÉTODOS: Foram selecionadas 29 crianças portadoras de alterações laríngeas exclusivas. Todas foram submetidas a exame otorrinolaringológico, nasofibrolaringoscopia e polissonografia. Foram tabulados dados relativos à idade, nasofibrolaringoscopia e polissonografia. Para análise, as crianças foram separadas em 2 grupos: portadores de laringomalácia e portadores de outras doenças laríngeas. RESULTADOS: Dentre as 18 crianças com diagnóstico de laringomalácia, 18 apresentaram eventos respiratórios do tipo central, sendo a maioria dos episódios associados à dessaturação de oxigênio e alguns à bradicardia. Nesse mesmo grupo, 3 crianças apresentaram apnéia do tipo obstrutivo. Por outro lado, as 11 crianças portadoras de outras alterações laríngeas não apresentaram predominância entre um tipo ou outro de apnéia, 4 apresentaram eventos respiratórios do tipo central, 2 do tipo obstrutivo. CONCLUSÃO: A maioria dos pacientes acometidos por laringomalácia apresentou eventos respiratórios do tipo central quando avaliados pela polissonografia. Já os pacientes com outras doenças laríngeas não apresentaram predominância entre um tipo ou outro de apnéia.Polysomnography is

  3. Perfil cardiovascular em pacientes com apneia obstrutiva do sono Perfil cardiovascular en pacientes con apnea obstructiva del sueño Cardiovascular profile in patients with obstructive sleep apnea

    Directory of Open Access Journals (Sweden)

    Fátima Dumas Cintra

    2011-04-01

    Full Text Available FUNDAMENTO: Apneia Obstrutiva do Sono (AOS é um fator de risco para várias condições cardiovasculares incluindo aumento na mortalidade cardiovascular. Sendo assim, é essencial o conhecimento das principais repercussões cardiovasculares dos distúrbios respiratórios do sono durante uma avaliação clínica. OBJETIVO: Analisar as características cardiovasculares de pacientes com AOS. MÉTODOS: Pacientes submetidos a polissonografia basal foram consecutivamente selecionados do banco de dados do Instituto do Sono entre março de 2007 e março de 2009. Todos os pacientes foram orientados a comparecer ao ambulatório para coleta de sangue, exame físico, eletrocardiograma de 12 derivações, espirometria, teste cardiopulmonar em esteira ergométrica e ecocardiograma transtorácico. O estudo foi aprovado pelo comitê de ética e pesquisa e registrado no site http://clinicaltrials.gov/ sob o número: NCT00768625. RESULTADOS: Foram analisados 261 pacientes e 108 controles. As principais características dos pacientes com AOS foram: obesidade, hipertensão, baixos níveis plasmáticos de lipoproteínas de alta densidade (HDL e aumento no diâmetro do átrio esquerdo quando comparados com controles (3,75 ± 0,42; 3,61 ± 0,41, p = 0,001, respectivamente. Essas características associadas correspondem a um acréscimo de 16,6 vezes na probabilidade de ocorrência de AOS independentemente do relato de algum sintoma dessa desordem, como sonolência ou ronco. CONCLUSÃO: Na amostra avaliada, o perfil cardiovascular dos pacientes com AOS mais encontrado foi: obesidade, hipertensão arterial, baixos níveis plasmáticos de HDL e átrio esquerdo com diâmetro aumentado.FUNDAMENTO: Apnea obstructiva del sueño (AOS es un factor de riesgo para diversas condiciones cardiovasculares, incluido el aumento en la mortalidad cardiovascular. Por tanto, es imprescindible conocer las principales repercusiones cardiovasculares de los trastornos respiratorios del sue

  4. BICENTENARIO DE LA INVENCIÓN DEL FONENDOSCOPIO (1916- 2016

    Directory of Open Access Journals (Sweden)

    Paula Ronderos

    2016-12-01

    , aumentan o se ausentan los ruidos húmedos, secos, finos o roncos, ásperos; cómo se oye el aire obstruido o el flujo de aire que se vuelve; el sonido de aire o líquido circulante: el pozo; se distingue el sonido de la diferencia cuando se incrementa el grosor de las paredes, del gorjeo o el roce de la pleura. Hay sonidos crepitantes, pequeños ruidos chasquantes, burbujeantes, estrepitosos; sibilancias chillonas colándose por vías estrechas.

  5. The Serra de Tramuntana World Heritage Site (Mallorca, Spain). Landslide activity valuation by means of Persistent Scatterers Interferometry

    Science.gov (United States)

    Mateos, Rosa Maria; Bianchini, Silvia; Herrera, Gerardo; Garcia, Inmaculada; Sanabria, Margarita

    2016-04-01

    cultural heritage sites. References: Bianchini S, Herrera G, Mateos RM, Notti D, García-Moreno I, Mora O, Moretti S (2013). Landslide Activity Maps Generation by means of Persistent Scattered Interferometry. Remote Sensing 5:6198-6222. Mateos R.M., García-Moreno I., Herrera G., Mulas J (2013) a. Damage caused by recent mass-movements in Majorca (Spain), a region with a high risk due to tourism. Landslide Science and Practice. Claudio Margottini, Paolo Canuti and Kyoji Sassa (Editors). Volume 7: Social and Economic Impact and Policies. 105-113. Mateos RM, Rodríguez-Peces M, Azañón JM, Rodríguez-Fernández FJ, Roldán FJ, García-Moreno I, Gelabert B, García-Mayordomo J (2013)b. El deslizamiento de Bàlitx (Mallorca) y su posible origen sísmico. Procesos activos desde el Pleistoceno superior. Boletín Geológico y Minero, 124 (1): 41-61

  6. El foro romano de Termes (Hispania Citerior. Síntesis histórica, arqueológica y topográfica. S. I a. C.- s. II d. C.

    Directory of Open Access Journals (Sweden)

    Martínez Caballero, Santiago

    2010-12-01

    progresiva superposición de estructuras en la zona. Durante la etapa Julio Claudia (14-37 d. C. se creó una nueva área pública, junto a la anterior, conformada por un recinto porticado con un templo. Este conjunto formaba parte de un espacio público principal, bien un Foro Julio Claudio, bien simplemente un santuario urbano. Finalmente, en época flavia, a partir de 75 d. C., el sitio del foro augusteo será transformado con la construcción de un gran cuadripórtico monumental y escenográfico, el Foro Flavio, complejo que se constituirá, al mismo tiempo, como un foro y un Augusteum, espacio de representación y santuario de culto dinástico.

  7. Variability of DTM-derived, morphometric parameters versus cell size. An example of application in Calabria (Southern Italy)

    Science.gov (United States)

    Rago, Valeria; Caloiero, Paola; Pellegrino, Annamaria Daniela; Iovine, Giulio G. R.; Terranova, Oreste G.; Pascale, Stefania

    2016-04-01

    , G. Gullà, G. Iovine, O. Petrucci, P. Salvador Sanchis, M. Sorriso-Valvo, O. Terranova, D. Torri, V. Bagarello, C. Di Stefano, V. Ferro, G. Buttafuoco, G. Callegari, P. Porto, B. Betrò, A. Bodini, C. Brambilla (2010) - Relazione Finale Contratto Lotto 2 Pericolosità legata ai fenomeni di intensa erosione idrica areale e lineare- POR Calabria 2000-2006, Azione. 1.4c. Rapporto per Autorità di Bacino Regione Calabria. Iovine G., Greco R., Gariano S.L., Pellegrino A.D., Terranova O.G. (2014) - Shallow-landslide susceptibility in the Costa Viola mountain ridge (southern Calabria, Italy) with considerations on the role of causal factors. Natural Hazards, 73(1), pp.111-136. In: G. Iovine & D. Cohen (Eds.), Advanced methods in landslide modelling. Iovine G., Greco R., Gariano S.L., Iaquinta P., Pellegrino A.D., Terranova O.G. (2013) - Shallow-landslide susceptibility in the Costa Viola mountain ridge (Italia). In: Landslide Science and Practice, Claudio Margottini, Paolo Canuti, Kyoji Sassa (Editors), Volume 3: Spatial Analysis and Modelling, pp.81-87. Proc. Second World Landslide Forum, 3-7 October 2011, Rome.

  8. Seasonal rockfall risk assessment along transportation network: a sample from Mallorca (Spain)

    Science.gov (United States)

    Mateos, Rosa Maria; Garcia, Inmaculada; Reichenbach, Paola; Herrera, Gerardo; Rius, Joan; Aguilo, Raul; Roldan, Francisco J.

    2014-05-01

    section of the road. For the risk analysis, four scenarios depending on the seasonal people exposition have been taken into account, considering the autumn as the season with the highest risk. This methodology can be applied to highly touristy areas such Mallorca, where the safety of the population and its visitors must be the priority of all concerned. References : Guzzetti, F., Crosta G., Detti, R. Agliardi, F., 2002: STONE: A computer program for the three-dimensional simulation of rock-falls. Computers Geosciences 28 (2002) 1079-1093. Mateos, R.M., García-Moreno, I., Azañón, J.M., 2012. Freeze-thaw cycles and rainfall as triggering factors of mass movements in a warm Mediterranean region: the case of the Tramuntana Range (Majorca, Spain). Landslides (2012), 9: 417-432. Mateos, R.M., García- Moreno, I., Herrera, G., Mulas, J., 2013b. Damage caused by recent mass-movements in Majorca (Spain), a region with a high risk due to tourism. Landslide Science and Practice. Claudio Margottini, Paolo Canuti and Kyoji Sassa (Editors). Volume 7: Social and Economic Impact and Policies. 105-113.

  9. Budget impact analysis of sofosbuvir-based regimens for the treatment of HIV/HCV-coinfected patients in northern Italy: a multicenter regional simulation

    Directory of Open Access Journals (Sweden)

    Cenderello G

    2015-12-01

    Full Text Available Giovanni Cenderello,1 Stefania Artioli,2 Claudio Viscoli,3 Ambra Pasa,4 Mauro Giacomini,5 Barbara Giannini,5 Chiara Dentone,6 Laura Ambra Nicolini,3 Giovanni Cassola,1 Antonio Di Biagio31Infectious Diseases Unit EO, Ospedali Galliera, Genoa, 2Infectious Diseases Unit, ASL-5 Spezzina, La Spezia, 3Infectious Diseases Unit, AOU San Martino, IST, Genoa University, Genoa, 4IT Unit, Ospedali Galliera, Genoa, 5Department of Informatics, Bioengineering, Robotics and System Engineering (DIBRIS, University of Genoa, Genova, 6Infectious Diseases Unit, ASL-1 Imperiese, Sanremo, Imperia, ItalyObjectives: Chronic hepatitis C virus (HCV is a leading cause of hospitalization and death in populations coinfected with human immunodeficiency virus (HIV. Sofosbuvir (SOF is a pan-genotypic drug that should be combined with other agents as an oral treatment for HCV. We performed a 5-year horizon budget impact analysis of SOF-based regimens for the management of HIV/HCV-coinfected patients.Methods: A multicenter, prospective evaluation was conducted, involving four Italian Infectious Diseases Departments (Galliera, San Martino, Sanremo, and La Spezia. All 1,005 genotype-coinfected patients (30% cirrhotics under observation were considered (patients in all disease-stages were considered: chronic hepatitis C, cirrhosis, transplant, hepatocellular carcinoma. Disease stage costs per patient were collected; the expected disease progression in the absence of treatment and sustained virological response (SVR success rate for SOF-based regimens were calculated based on the literature and expert opinion. Drug prices were based on what the National Health Service paid for them. The comparison of "no treatment" disease progression costs versus the economic impact of SOF-based regimens was investigated.Results: Over the following 5 years, the disease progression scenario resulted in direct costs of approximately €54 million. Assuming an SVR success rate of 90%, average SOF

  10. Analysis of cardiac autonomic modulation of children with attention deficit hyperactivity disorder

    Directory of Open Access Journals (Sweden)

    de Carvalho TD

    2014-04-01

    Full Text Available Tatiana Dias de Carvalho,1,2 Rubens Wajnsztejn,3 Luiz Carlos de Abreu,2,7 Luiz Carlos Marques Vanderlei,4 Moacir Fernandes Godoy,5 Fernando Adami,2 Vitor E Valenti,6 Carlos B M Monteiro,2,7 Claudio Leone,7 Karen Cristina da Cruz Martins,2 Celso Ferreira11Departamento de Medicina, Disciplina de Cardiologia, Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil; 2Laboratório de Escrita Científica da Faculdade de Medicina do ABC, FMABC, Santo André, Brazil; 3Núcleo Especializado em Aprendizagem, Programa de pós-graduação em Ciências da Saúde da Faculdade de Medicina do ABC, FMABC, Santo André, Brazil; 4Departamento de Fisioterapia da Faculdade de Ciências e Tecnologia, Universidade Estadual Paulista, UNESP, Presidente Prudente, São Paulo, Brazil; 5Núcleo Transdisciplinar de Estudos do Caos e da Complexidade. Faculdade de Medicina de São José de Rio Preto, FAMERP, São José do Rio Preto, Brazil; 6Departamento de Fonoaudiologia da Faculdade de Filosofia e Ciências, Universidade Estadual Paulista, UNESP, Marília, Brazil; 7Departamento de Saúde Materno-Infantil da Faculdade de Saúde Pública da Universidade de São Paulo, São Paulo, BrazilBackground: Attention deficit hyperactivity disorder (ADHD is characterized by decreased attention span, impulsiveness, and hyperactivity. Autonomic nervous system imbalance was previously described in this population. We aim to compare the autonomic function of children with ADHD and controls by analyzing heart rate variability (HRV.Methods: Children rested in supine position with spontaneous breathing for 20 minutes. Heart rate was recorded beat by beat. HRV analysis was performed in the time and frequency domains and Poincaré plot.Results: Twenty-eight children with ADHD (22 boys, aged 9.964 years and 28 controls (15 boys, age 9.857 years participated in this study. It was determined that the mean and standard deviation of indexes which indicate parasympathetic activity is higher in

  11. PREFACE: EPS Euroconference XIX Nuclear Physics Divisional Conference: New Trends in Nuclear Physics Applications and Technology

    Science.gov (United States)

    2006-06-01

    . Role of Nuclear Techniques in Environment Problems. Applications of Nuclear Techniques relevant for Civil Security (contraband and explosive detection, search for Weapons of Mass Destruction, Nuclear Safeguards). Nuclear Applications in Space Research. Material and Structure Testing in Research and Industry. New contributions of Nuclear Techniques to the solution of the Energy Production problems and Nuclear Waste Transmutation. Emerging experimental techniques, new detectors and new modeling tools. During the Monday morning Session of the Conference, the 2005 IBA-EUROPHYSICS PRIZE for Applied Nuclear Science and Nuclear Methods in Medicine, sponsored by the Belgian company IBA, was awarded to the two laureates Werner Heil (Mainz) and Pierre Jean Nacher (Paris) for the development of spin polarized 3He targets by optical pumping and their applications in nuclear science and medicine. The meeting was a real success, with 18 invited talks, 66 contributed talks and 31 posters and an overall participation, during five full days, of around 150 scientists from different European and non-European countries. It also hosted a three day industrial exhibition of a selection of Companies that sponsored the event. The Organisers take thos opportunity to thank the University of Pavia, the Amministrazione Comunale di Pavia and the Provincia di Pavia, as well as all exhibitors (Ametek, Ansaldo Superconduttori, Caen, Else, Hamamatsu, IBA, Micos, Micron Semiconductor), for their support of the Conference. The Organisers finally wish to thank the Scientific Secretary of the Conference, Dr Andrea Fontana of INFN Pavia, for the huge amount of work done in preparing the Conference, Mr Claudio Casella of the Department of Nuclear and Theoretical Physics of the University of Pavia for technical support and the Conference staff, Dr Gaia Boghen and the graduate students Federica Devecchi and Silvia Franchino, for their invaluable help. The very effective and professional work of the staff of

  12. Editorial v. 4, n. 3

    Directory of Open Access Journals (Sweden)

    Júlio Araujo Carneiro da Cunha

    2016-01-01

    Full Text Available O ano de 2015 foi marcado por avanços e mudanças na PODIUM Sport, Leisure and Tourism Review. Numa retrospectiva dos indicadores da revista ao longo do ano, tivemos 23 artigos publicados em três edições. Houve 67 autores que representaram 21 instituições de ensino do país, além de outras duas universidades estrangeiras. Pudemos contar também com diversos avaliadores ad hoc que atuaram com pareceres aos trabalhos submetidos à revista ao longo deste ano. Aproveito a oportunidade para agradecer mais uma vez o trabalho voluntário desses pareceristas que ajudam a incrementar a qualidade dos trabalhos da revista, o que sustenta o avanço das áreas de Gestão do Esporte, Lazer e Turismo com um conhecimento cada vez mais robusto. A partir de outubro de 2015 a revista PODIUM Sport, Leisure and Tourism Review contou com mudanças da sua equipe editorial. Assumi a chefia editorial da revista juntamente com o suporte do Diego Janes, novo assistente editorial da revista. Trabalhamos juntos com o assistente editorial Altieres de Oliveira Silva que continua a apoiar a Podium. Aproveito a oportunidade para agradecer ao prof. João Manuel Casquinha Malaia Santos pelos serviços prestados até aqui como editor-chefe da revista e também à Camila de Oliveira Prado pelo apoio oferecido como assistente editorial nesse mesmo período. Os trabalhos prestados por eles devem ser enaltecidos porque foram, sem dúvida, fundamentais para a estruturação da revista e pela legitimação dela perante a comunidade acadêmica. Diante desses novos desafios, apresento os sete trabalhos publicados nesse último número de 2015 da Podium. O primeiro artigo leva o título de “O papel do envolvimento e do orgulho nas decisões de consumo de pacotes de preços: um estudo com ingressos de futebol no Brasil” e tem como autoria Claudio Hoffmann Sampaio, Jefferson Dobner Sordi e Marcelo Gattermann Perin. Neste estudo, os autores identificaram o quanto os pacotes de pre

  13. Principals Of Radiation Toxicology: Important Aspects.

    Science.gov (United States)

    Popov, Dmitri; Maliev, Slava; Jones, Jeffrey

    . 1990, 2012] Moderate and high doses of radiation induces necrosis of radiosensitive cells with the subsequent formation of radiation toxins and their induced acute inflammatory processes. Radiation necrosis is the most substantial and most severe form of radiation induced injury, and when widespread, has grave therapeutic implications. [D. Popov et al. 1990, 2012,Claudio A. et al. 2002, Robertson J. et al. 2002, ] Relatively small doses of Radiation Toxins induce apoptosis and high doses of Radiation Toxins induce necrosis. [Rastogi P. et al. 2009, D. Popov et al. 1990, 2012,] Threshold of Toxic Effects occurs and can be defined. [D. Popov et al. 2012, ] Radiation Toxins affects Somatic cells and Germ Cells. Radiation Toxins can induce teratogenic processes. Specific Toxicity of Radiation Toxins can affects developing fetus. Material and Methods, Results: http://www.intechopen.com/books/current-topics-in-ionizing-radiation-research/radiation-toxins-molecular-mechanisms-of-toxicity-and-radiomimetic-properties- Conclusion: Radiation is a physical agent - induce activation of some secretory proteins with high enzymatic activity. This proteins called as Radiation Toxins can produce specific for radiation biological and toxic effects after administration to radiation naive mammals. [V. Maliev et al. 2007, D. Popov et al. 1990, 2012] Radiation Toxins are teratogenic and oncogenic. Radiation Toxins effects depend on Administered Dose and Radiation effects depend on Exposure Dose and Absorbed Dose. The levels of Radiation Toxins correlates with Radiation Exposure.

  14. Roadway management plan based on rockfall modelling calibration and validation. Application along the Ma-10 road in Mallorca (Spain)

    Science.gov (United States)

    Mateos, Rosa Maria; Garcia, Inmaculada; Reichenbach, Paola; Herrera, Gerardo; Sarro, Roberto; Rius, Joan; Aguilo, Raul

    2016-04-01

    taking into account, not only the success, but also the mistakes. We have further validated the calibrated parameters along the Ma-road using the 63 rockfall recorded during the past 18 years along the road. 81.5% of the rockfalls are well represented by STONE modelling. Results have been exploited by the Road Maintenance Service of Mallorca for the design of the following road management plan: (1) Phase 1. Short-term. Design a specific plan for the road- sections where rockfalls were registered and modelling results were obtained. A large investment will be expended for implementation of retention and protection measures. (2) Phase 2. Medium-term. Design a specific plan for the road- sections where rockfalls were registered but no modelling results were obtained. For these cases, new studies at local scale are necessary as well as the application of other modelling software which include higher resolution input data. (3) Phase 3. Long-term. Design a specific plan for the road- sections where no rockfalls were registered but modelling results were obtained. These are potential rockfall areas and local and specific ground studies are necessaries. References Mateos RM (2006) Los movimientos de ladera en la Serra de Tramuntana (Mallorca). Caracterización geomecánica y análisis de peligrosidad. PhD. Servicio de Publicaciones de la Universidad Complutense de Madrid. Madrid, 299 p. Mateos RM, García-Moreno I, Herrera G, Mulas J (2013) Damage caused by recent mass-movements in Majorca (Spain), a region with a high risk due to tourism.Landslide Science and Practice.Claudio Margottini, Paolo Canuti and KyojiSassa (Editors). Volume 7: Social and Economic Impact and Policies. 105-113. Guzzetti F, Crosta G, Detti R, Agliardi F (2002) STONE: A computer program for the three-dimensional simulation of rock-falls. Computers Geosciences. Vol. 28:1079-1093.

  15. PREFACE: VII Brazilian Congress on Metrology (Metrologia 2013)

    Science.gov (United States)

    Costa-Félix, Rodrigo; Bernardes, Americo; Valente de Oliveira, José Carlos; Mauro Granjeiro, José; Epsztejn, Ruth; Ihlenfeld, Waldemar; Smarçaro da Cunha, Valnei

    2015-01-01

    ) Brazilian National Institute of Metrology, Quality and Technology jcoliveira@inmetro.gov.br José Mauro Granjeiro (Editor on Biotechnology) Brazilian National Institute of Metrology, Quality and Technology jmgranjeiro@inmetro.gov.br Ruth Epsztejn (Editor on Conformity Assessment) Brazilian National Institute of Metrology, Quality and Technology repsztejn@inmetro.gov.br Waldemar Ihlenfeld (Editor on Electrical Metrology) Brazilian National Institute of Metrology, Quality and Technology wgihlenfeld-pronametro@inmetro.gov.br Valnei Smarçaro da Cunha (Editor on Chemistry Metrology) Brazilian National Institute of Metrology, Quality and Technology vscunha@inmetro.gov.br Technical and Scientific Committee for Metrologia 2013 Ado Jório (UFMG) Carlos Achete (UFRJ, Inmetro) Flávio Vasconcelos (UFMG) Giorgio Moscati (USP) Hans Peter Grieneisen (Inmetro) Humberto Brandi (Inmetro) José Carlos Valente de Oliveira (Inmetro) José Guilherme Pereira Peixoto (IRD) José Mauro Granjeiro (Inmetro) Luiz Claudio Moreira Paschoal (Petrobras) Luis Fernado Rust (Inmetro) Luiz Silva Mello (PUC RJ) Marcos Nogueira Eberlin (Unicamp) Oleksii Kuznetsov (Inmetro) Regis Landim (Inmetro) Ricardo Carvalho (ON) Rodrigo Costa-Felix (Inmetro) Romeu José Daroda (Inmetro) Ruth Epsztejn (Inmetro) Valnei Smarçaro da Cunha (Inmetro) Valter Aibe (Inmetro) Waldemar Guilherme Kürten Ihlenfeld (PTB) Wanderley de Souza (UFRJ, Inmetro)

  16. Cannabis and intractable chronic pain: an explorative retrospective analysis of Italian cohort of 614 patients

    Directory of Open Access Journals (Sweden)

    Fanelli G

    2017-05-01

    Full Text Available Guido Fanelli,1,2 Giuliano De Carolis,3 Claudio Leonardi,4 Adele Longobardi,5,6 Ennio Sarli,7,8 Massimo Allegri,1,2 Michael E Schatman9 1Anesthesia, Critical Care and Pain Medicine Unit, Division of Surgical Sciences, Department of Medicine and Surgery, University of Parma, 2Anesthesia, Intensive Care and Pain Therapy Service, Azienda Ospedaliero Universitaria Parma, Parma, 3Pain Therapy Service, Azienda Ospedaliero Universitaria Pisana, Pisa, 4Department of Drug Addiction Diseases, Local Public Health of Rome, Rome, 5Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, Naples, 6Young Against the Pain (YAP Group, Parma, 7Progetti Live Surgery, 8PinHub Group, Florence, Italy; 9Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA Background: Despite growing interest in the therapeutic use of cannabis to manage chronic pain, only limited data that address these issues are available. In recent years, a number of nations have introduced specific laws to allow patients to use cannabis preparations to treat a variety of medical conditions. In 2015, the Italian government authorized the use of cannabis to treat several diseases, including chronic pain generally, spasticity in multiple sclerosis, cachexia and anorexia among AIDS and cancer patients, glaucoma, Tourette syndrome, and certain types of epilepsy. We present the first snapshot of the Italian experience with cannabis use for chronic pain over the initial year of its use.Methods: This is a retrospective case series analysis of all chronic pain patients treated with oral or vaporized cannabis in six hubs during the initial year following the approval of the new Italian law (December 2015 to November 2016. We evaluated routes of administration, types of cannabis products utilized, dosing, and effectiveness and safety of the treatment.Results: As only one of the six centers has

  17. Low-dose oral prolonged-release oxycodone/naloxone for chronic pain in elderly patients with cognitive impairment: an efficacy–tolerability pilot study

    Directory of Open Access Journals (Sweden)

    Petrò E

    2016-03-01

    Full Text Available Emiliano Petrò,1 Elena Ruffini,1 Melania Cappuccio,2 Valeria Guerini,2 Gloria Belotti,3 Sara Fascendini,4 Cristina Licini,4 Claudio Marcassa51Rehabiliation and Alzheimer Unit, San Pietro Polyclinic, Ponte San Pietro, 2Alzheimer Center, P. Gusmini Foundation, Vertova, 3Santa Maria Ausiliatrice Foundation, Bergamo, 4Alzheimer Center, Briolini Hospital FERB ONLUS, Gazzaniga, 5Cardiology, Maugeri Foundation IRCCS, Veruno, ItalyObjective: This pilot study evaluated the efficacy and safety of prolonged-release oxycodone/naloxone (OXN-PR in older subjects with chronic pain and mild-to-moderate cognitive impairment.Methods: This was a prospective, observational, open-label study of 45-day duration. Patients with moderate-to-severe chronic pain and naïve to strong opioids were recruited from nursing homes and Alzheimer’s disease centers. OXN-PR was initiated at low doses (5 mg od or bid and increased to a maximum of 20 mg bid. The primary efficacy endpoint was a pain intensity reduction of ≥30% from baseline (T0 to 15 days after OXN-PR initiation, as assessed by a numerical rating scale or the Pain Assessment in Advanced Dementia scale. Other assessments included the Barthel activities of daily living index, Neuropsychiatric Inventory, Bowel Function Index, and adverse events.Results: The analysis included 53 patients (mean age, 83.0 years; mean Mini-Mental State Examination score, 18.6 with severe pain (median Numerical Rating Scale/Pain Assessment in Advanced Dementia 6 and substantial impairment in daily functioning (mean Barthel index, 32.2. The primary endpoint was achieved by 92.4% of patients. OXN-PR significantly reduced mean pain intensity from baseline to study end (numerical rating scale, 6.6±1.0 vs 2.3±1.1, P<0.0001; Pain Assessment in Advanced Dementia, 6.9±1.6 vs 0.9±0.8, P<0.0001. Substantial improvements from T0 to T45 in daily functioning (mean Barthel index, 32.2±16.8 vs 53.7±23.9, P<0.0001 and neuropsychiatric symptoms

  18. Randomized clinical trial comparing manual suture and different models of mechanical suture in the mimicking of bariatric surgery in swine

    Directory of Open Access Journals (Sweden)

    Fernandes MA

    2014-02-01

    Full Text Available Marcos AP Fernandes,1 Bruno MT Pereira,2 Sandra M Guimarães,1 Aline Paganelli,3 Carlos Manoel CT Pereira,1 Claudio Sergio Batista4 1Institute of Obesity and Advanced Video Laparoscopic Surgery of Petropolis, Rio de Janeiro, Brazil; 2Division of Trauma, University of Campinas, São Paulo, Brazil; 3Laboratório de Patologia Micron Cell Diagnóstico, Rio de Janeiro, Brazil; 4Department of Gynecology and Obstetrics, Faculty of Medicine of Petropolis, Rio de Janeiro, Brazil Context and objective: Variations in the ability of surgeons served as motivation for the development of devices that, overcoming individual differences, allow the techniques to be properly performed, and of which the end result was the best possible. Every technique must be reproduced reliably by the majority of surgeons for their results to be adopted and recognized as effective. The aim of this study was to compare the results, from the point of view of anatomic pathology, of manual sutures versus mechanical sutures using different models of linear mechanical staplers, in the procedure of gastroenteroanastomosis and enteroanastomosis in swine. Methods: Thirty-six healthy, adult, male Sus scrofa domesticus pigs, weighing between 20.7 and 25.5 kg, were used. The swine were randomly divided into four groups of nine pigs, according to the type of suture employed: group A, manual suture with Polysorb® 3-0 wire; group B, 80-shear linear stapler (Covidien® Gia 8038-S; group C, 75-shear linear stapler (Ethicon® Tlc 75; and group D, 75-shear linear stapler (Resource® Yq 75-3. A temporal study was established on the seventh postoperative day for histopathological analysis, and the degree of inflammation, fibrosis, and newly formed vessels, as well as the presence or absence of granulation tissue, foreign body granuloma, and necrosis were all evaluated qualitatively and semiquantitatively. The results were analyzed statistically. Results: Observations during the histopathological

  19. Prognostic value of ferritin, neuron-specific enolase, lactate dehydrogenase, and urinary and plasmatic catecholamine metabolites in children with neuroblastoma

    Directory of Open Access Journals (Sweden)

    Cangemi G

    2012-11-01

    Full Text Available Giuliana Cangemi,1 Giorgio Reggiardo,2 Sebastiano Barco,1 Laura Barbagallo,1 Massimo Conte,3 Paolo D'Angelo,4,# Maurizio Bianchi,5,# Claudio Favre,6,# Barbara Galleni,3 Giovanni Melioli,1 Riccardo Haupt,7 Alberto Garaventa,3 Maria V Corrias81Clinical Pathology Laboratory Unit, Giannina Gaslini Institute, Genoa, Italy; 2Data Management and Biostatistics Unit, Medi Service, Genoa, Italy; 3Department of Hematology-Oncology, Giannina Gaslini Institute, Genoa, Italy; 4Pediatric Oncology Unit, Azienda Civico, Di Cristina e Benfratelli, Palermo, Italy; 5Pediatric Onco-Hematology, Stem Cell Transplantation and Cellular Therapy Division, Regina Margherita Children's Hospital, Turin, Italy; 6Department of Hematology-Oncology, Pisana University Hospital, Pisa, Italy; 7Epidemiology and Biostatistics Unit, Giannina Gaslini Institute, Genoa, Italy; 8Laboratory of Oncology, Giannina Gaslini Institute, Genoa, Italy#On behalf of the Italian Association of Pediatric Hematology and Oncology (AIEOPAbstract: Different plasma and urinary parameters have been tested as valuable prognostic markers for children with neuroblastoma (NB, but conclusive results from multivariate analyses are still lacking. Samples collected at diagnosis from 505 patients diagnosed in Italy between June 1994 and November 2010 were analyzed at the Italian reference laboratory according to standard methodologies. Patient clinical data were retrieved from the Italian NB Registry. For statistical analysis, patients were grouped according to stage, age, MYCN status, and outcome. Cumulative survival was calculated by the Kaplan–Meier procedure using the first quartile of the marker distribution as a cut-off value to stratify the patients. Multivariate analysis was performed by the Cox regression model by considering only the significant variables. When the entire cohort of patients was considered, none of the different parameters had an independent prognostic value. However, in patients with

  20. Uso de preditores clínicos simples no diagnóstico pré-operatório de dificuldade de intubação endotraqueal em pacientes portadores de obesidade Uso de predictores clínicos sencillos en el diagnóstico preoperatorio de dificultad de intubación endotraqueal en pacientes obesos Use of simple clinical predictors on preoperative diagnosis of difficult endotracheal intubation in obese patients

    Directory of Open Access Journals (Sweden)

    Edno Magalhães

    2013-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Apesar da semelhante incidência de dificuldade à laringoscopia em obesos e não obesos há mais relatos de dificuldade de intubação endotraqueal em portadores de obesidade. Alternativas de diagnóstico e previsão de dificuldade de intubação no pré-operatório podem ajudar diminuir complicações anestésicas em indivíduos obesos. O objetivo do estudo foi identificar preditores para diagnóstico de via aérea difícil em pacientes obesos, pela correlação com métodos clínicos de avaliação pré-anestésica e polissonografia. Comparou-se também a incidência de dificuldade à ventilação sob máscara facial e à laringoscopia entre obesos e não obesos, verificando os preditores mais prevalentes. MÉTODOS: Estudo observacional, prospectivo, comparativo, com 88 pacientes adultos, submetidos à anestesia geral. No período pré-operatório, avaliou-se questionário sobre preditores clínicos de síndrome da apneia obstrutiva do sono (SAOS e parâmetros anatômicos. Durante a anestesia, pesquisou-se dificuldade à ventilação sob máscara facial e laringoscopia. Para análise, estatística descritiva e teste de correlação. RESULTADOS: Os pacientes foram alocados em dois grupos, 43 obesos e 45 não obesos. Estado físico, prevalência de roncos, hipertensão e diabetes mellitus, circunferência cervical e índice de Mallampati foram maiores nos obesos. Pacientes obesos apresentaram maior incidência de dificuldade de ventilação sob máscara e laringoscopia. Nenhuma variável clínica ou anatômica apresentou correlação com dificuldade de ventilação sob máscara nos grupos. Nos obesos, o diagnóstico de SAOS mostrou forte correlação com dificuldade à laringoscopia. CONCLUSÕES: Os diagnósticos clínico e polissonográfico de SAOS se mostraram úteis no diagnóstico pré-operatório de dificuldade à laringoscopia. Pacientes obesos estão mais propensos à dificuldade de ventilação sob máscara e

  1. Solos da bacia de Taubaté (Vale do Paraíba: levantamento de reconhecimento. Séries monotípicas, suas propriedades genético-morfológicas, físicas e químicas Soils of Taubaté basin (Paraíba Valley

    Directory of Open Access Journals (Sweden)

    F. C. Verdade

    1961-01-01

    Full Text Available A Bacia tie Taubaté corresponde a um «vale de afundimento», onde ocorreram sedimentações no período Terciário, estando atualmente moldada pelo rio Paraíba e seus tributários. A planície aluvial é extensa e de grande importância econômica para o Estado de São Paulo. No presente trabalho é apresentado o levantamento de reconhecimento dos solos da Bacia de Taubaté, cujas finalidades foram determinar as características fisicas e químicas das terras e sua extensão aproximada, visando fornecer dados para o planejamento geral de irrigação e drenagem, ao mesmo tempo que eram identificados os tipos de solos (séries monotipicas para o levantamento detalhado que se processa a partir do município de Pindamonhangaba. As categorias dos solos foram estabelecidas até séries monotípicas, mas a delimitação no campo, em mapas na escala de 1:100 0(0. foi feita nas unidades chamadas associação de séries. Procurou-se grupar na mesma associação solos que, pertencendo ao mesmo grande grupo e formação geológica, tivessem no perfil igual distribuição de classes texturais. Alguns solos, devido à sua pequena extensão ou da ocorrência íntima com outros de associações diferentes, fugiram à regra preliminarmente exposta. O levantamento abrange uma área de 222 980 hectares, incluindo a planície aluvial, as sedimentações terciárias e pequena faixa pré-cambriana que orla a Bacia. Foram estudados 151 perfis, caracterizando 48 séries monotípicas, grupadas em 18 associações de séries. A associação de séries A é constituída de solos pertencentes a sub-ordem Latossolo, formados em sedimentos do Terciário com textura argilosa em todos os horizontes. Os perfis dêstes solos apresentam um horizonte A3 normalmente adensado e um B friável. Compreendem as séries monotipicas: Borda, Cajuru, Feital, Gleba, Guatemala, Pinda, Pinhão, Polêmica, Ponte Alta, Rapadura e Ronco.The Taubaté Basin represents a > where sediments were

  2. Eating on an interconnected planet

    Science.gov (United States)

    MacDonald, Graham K.

    2013-06-01

    Balance Sheets: A Handbook (Rome: United Nations Food and Agriculture Organization) FAO (Food and Agriculture Organization) 2013 FAOSTAT: FAO Statistical Databases (Rome: United Nations Food and Agriculture Organization) Foley J A et al 2011 Solutions for a cultivated planet Nature 478 337-42 Headey D 2011 Rethinking the global food crisis: the role of trade shocks Food Policy 36 136-46 Hertel T W, Burke M B and Lobell D B 2010 The poverty implications of climate-induced crop yield changes by 2030 Glob. Environ. Change 20 577-85 Kastner T, Rivas M J I, Koch W and Nonhebel S 2012 Global changes in diets and the consequences for land requirements for food Proc. Natl Acad. Sci. 109 6868-72 Lambin E F and Meyfroidt P 2011 Global land use change, economic globalization, and the looming land scarcity Proc. Natl Acad. Sci. 108 3465-72 Lobell D B, Cassman K G and Field C B 2009 Crop yield gaps: their importance, magnitudes, and causes Annu. Rev. Environ. Resour. 34 179 Naylor R L and Falcon W P 2010 Food security in an era of economic volatility Popul. Dev. Rev. 36 693-723 Ray D K, Ramankutty N, Mueller N D, West P C and Foley J A 2012 Recent patterns of crop yield growth and stagnation Nature Commun. 3 1293 Suweis S, Rinaldo A, Maritan A and D'Odorico P 2013 Water-controlled wealth of nations Proc. Natl Acad. Sci. 110 4230-3 Thornton P K, Jones P G, Alagarswamy G and Andresen J 2009 Spatial variation of crop yield response to climate change in East Africa Glob. Environ. Change 19 54-65

  3. Comentario a la presentación del libro "70 años del Cáncer en Colombia" del Académico Efraim Otero Ruiz

    Directory of Open Access Journals (Sweden)

    Alfonso Latiff Conde

    2002-08-01

    Full Text Available

    Estoy maravillado con el monumental esfuerzo y trabajo de Efraim Otero-Ruiz en la producción de su portentoso libro “Setenta años del cáncer en Colombia”.

    Escrito en una prosa amena y armoniosa, su lectura es verdadero deleite intelectual para quien sigue la apasionante madeja que constituye toda la trama inicial y que envuelve la concepción, el nacimiento y el desarrollo de una institución para el tratamiento del cáncer en Colombia.

    Es apasionante la forma como Efraim toma el hilo de la historia desde sus primeras y más importantes incepciones.

    Es sin duda Claudio Regaud, Jefe del Laboratorio de Radiofisiología del Instituto de Radium de París, la figura clave en la iniciativa de creación de un Instituto de Radium en Colombia. Alfonso Esguerra Gómez, becario de la Institución adquiere una valiosa experiencia en el tratamiento de tumores superficiales de cara y cuello y descubre la famosa pasta Colombia que permite amoldarse sobre la piel mientras en su interior se colocan las agujas de radium.

    En la década de los veinte Regaud se convierte en la figura más prestante en el mundo en el manejo del radium y es invitado universalmente para comunicar no solo sus experiencias sino como consejero y orientador de la creación de institutos de radium en el mundo.

    La invitación a Regaud en 1928 para visitar el Perú es conocida por Alfonso Esguerra y allí por primera vez se organiza un movimiento de influencias que con agudo análisis describe Efraim Otero, para movilizar todas las fuerzas académicas y políticas con el fin de aprovechar esta oportunidad y obtener la visita de Regaud a Colombia.

    En varias ocasiones en el futuro, circunstancias similares harán necesaria la influencia de médicos, no solo eminentes sino dotados de excelentes conexiones sociales y políticas para crear el Instituto Nacional de Radium.

    Efraím se introduce por todos los vericuetos académicos, cient

  4. Apresentação

    Directory of Open Access Journals (Sweden)

    Os Editores

    2013-12-01

    com o movimento cultural e político que faz a revisão da história da criação de Israel. Por fim, o último artigo do dossiê, o de Ignacio Del Valle Dávila e Carolina Amaral de Aguiar, traz as visões complementares sobre o primeiro ano do governo da Unidade Popular (1970-1973 do presidente Salvador Allende presente em Compañero presidente (Miguel Littin, 1971 e El diálogo de América (Álvaro Covacevich, 1972, realçando as tensões ideológicas decorrentes das visões que a esquerda tinha da experiência chilena. Na seção de artigos livres, Arilson Oliveira recupera o sentido histórico da rosa e do riso a propósito de O Nome da Rosa (1986, de Jean-Jacques Annaud. Claudio Coração identifica os aspectos relacionados ao problema da comunicação em Amores Brutos (2000, 21 Gramas (2003 e Babel (2006, de Alejandro González Iñárritu. Roberta Veiga recompõe o desenho do mecanismo fílmico de Jean-Luc Godard, em Passion (1982, a partir da pintura, da discussão sobre o tempo e do político. Rodrigo Carreiro analisa como os falsos documentários de horror codificados como found footage tem sido massivamente realizados nas últimas duas décadas. Por fim, André Brasil se dedica ao exame do conceito de antecampo pensado a partir de dois documentários - Pi’õnhitsi  e  Mokoi Tekoá Petei Jeguatá , vinculados ao cinema indígena da equipe Vídeo das Aldeias.A Revista dá continuidade neste número à seção de resenhas, valorizando o debate em torno da produção acadêmica recente. Boa leitura! Os editores

  5. BAELO CLAUDIA Y POLLENTIA: NUEVAS EVIDENCIAS SOBRE LAS FLUCTUACIONES ECONÓMICAS EN LA HISPANIA ROMANA DE LOS SIGLOS I-II D. C. (Baelo Claudia and Pollentia: new evidence on the economic fluctuations in Roman Spain during the first and second centuries AD

    Directory of Open Access Journals (Sweden)

    Pascual Izquierdo-Egea

    2012-06-01

    Full Text Available La revisión cronológica de la necrópolis sureste de Baelo Claudia (Bolonia-Tarifa, Cádiz y la de Can Fanals, en Pollentia (Alcudia, Mallorca, ha permitido ampliar el conocimiento sobre las fluctuaciones económicas en la Hispania romana de los siglos I y II de nuestra era y los cambios sociales asociados a las mismas. Se ha obtenido una nueva confirmación del impacto de la gran crisis de tiempos de Tiberio en los registros funerarios de Baelo Claudia y Pollentia, detectada previamente en Ampurias o Emporiae (Gerona. La bonanza de la época de Claudio se puede comprobar en Baelo Claudia de forma más elocuente que en Emporiae. Ahora bien, esta coincidencia en el devenir económico se rompe a lo largo de la segunda mitad del siglo I d. C., en concreto durante el periodo comprendido entre Nerón y principios de los Flavios. Es entonces cuando, frente a la decadente Ampurias, una pujante Pollentia sigue los pasos de la opulenta Baelo mostrando su mayor prosperidad. Sin embargo, esas tres ciudades romanas de Hispania mantienen un claro nexo basado en la exhibición durante ese periodo de su máxima complejidad social. Siempre se da una proporción directa entre la acumulación económica amortizada en los ajuares y la diferenciación entre los individuos, salvo en dos casos excepcionales. Uno, ya conocido, se refiere a la Ampurias de la segunda mitad del siglo I d. C., donde el empobrecimiento que la caracteriza se asocia con un incremento de la distancia social. Y, el otro, corresponde al extraño fenómeno documentado en la Pollentia del siglo II d. C. En esta sigue creciendo el gasto funerario, pero la diferenciación social medida desciende durante la primera mitad hasta caer abruptamente a lo largo de la segunda parte de dicha centuria. No obstante, lo más importante es que, por ahora, se detecta la misma evolución de la diferenciación social en Emporiae, Baelo Claudia y Pollentia desde la época de Tiberio hasta la primera mitad del

  6. PREFACE: Workshop Photograph and Program

    Science.gov (United States)

    2011-07-01

    Workshop photograph Workshop Program Sunday 28 March 201019:00-21:00 Reception at Okura Frontier Hotel Tsukuba(Buffet style dinner with drink) Monday 29 March 2010Introduction (Chair: André Rubbia (ETH Zurich))09:00 Welcome address (05') Atsuto Suzuki (KEK)09:05 Message from CERN on neutrino physics (10') Sergio Bertolucci (CERN)09:15 Message from FNAL on neutrino physics (10') Young Kee Kim (FNAL)09:25 Message from KEK on neutrino physics (10') Koichiro Nishikawa (KEK)09:35 Introductory remark on GLA2010 (10') Takuya Hasegawa (KEK) Special session (Chair: Koichiro Nishikawa (KEK))09:45 The ICARUS Liquid Argon TPC (45') Carlo Rubbia (CERN)10:30-11:00 Coffee break Main goals of Giant Liquid Argon Charge Imaging Experiments I (Chair: Takashi Kobayashi (KEK))11:00 Results from massive underground detectors (non accelerator) (30') Takaaki Kajita (ICRR, U. of Tokyo)11:30 Present long baseline neutrino experiments (30') Chang Kee Jung (SUNY Stony Brook)12:00-12:10 Workshop picture12:10-14:00 Lunch break Main goals of Giant Liquid Argon Charge Imaging Experiments II (Chair: Takashi Kobayashi (KEK))14:00 Physics goals of the next generation massive underground experiments (30') David Wark (Imperial College London)14:30 Near detectors for long baseline neutrino experiments (20') Tsuyoshi Nakaya (Kyoto U.) Lessons on Liquid Argon Charge Imaging technology from ongoing developments (Chair: Chang Kee Jung (SUNY Stony Brook))14:50 WARP (30') Claudio Montanari (U. of Pavia)15:20 ArDM (30') Alberto Marchionni (ETH Zurich)15:50 From ArgoNeuT to MicroBooNE (30') Bonnie Fleming (Yale U.)16:20 250L (30') Takasumi Maruyama (KEK)16:50 The DEAP/CLEAN project (20') Mark Boulay (Queen's U.)17:10-17:40 Coffee break Lessons from Xe based Liquids Imaging detectors (Chair: Flavio Cavanna (U. of L'Aquilla))17:30 MEG (20') Satoshi Mihara (KEK)17:50 The XENON project (20') Elena Aprile (Columbia U.)18:10 XMASS (20') Hiroyuki Sekiya (ICRR, U. of Tokyo) Studies on physics performance (Chair

  7. Reseñas de Libros

    Directory of Open Access Journals (Sweden)

    José Miguel Delgado Idarreta

    2009-12-01

    Full Text Available Andrés Cabello, Sergio; Capellán de Miguel, Gonzalo; Fandiño Pérez, Roberto y Orduña Prada, Mónica, La transición a la democracia en La Rioja. Logroño, Gobierno de La Rioja, 2001, 291 pp.Páginas 199-200José Miguel Delgado IdarretaBeneyto, José María; Martín de la Guardia, Ricardo y Pérez Sánchez, Guillermo (dirs., Europa y Estados Unidos. Una historia de la relación atlántica en los últimos cien años. Madrid, Biblioteca Nueva, 2005, 356 pp.Páginas 201-203David Molina RabadánBosworth, Richard J. B., Mussolini’s Italy. Life under the Fascist Dictatorship 1915-1945. New York, Penguin, 2006, 692 pp.Páginas 203-205Jan NelisDávila A., Mireya; Fuentes S., Claudio (eds., Promesas de cambio. Izquierda y derecha en el Chile contemporáneo. Santiago de Chile, Editorial Universitaria, FLACSO, 2003, 189 pp.Páginas 205-208David Oviedo SilvaDelgado Idarreta, José Miguel; Andrés Cabello, Sergio, Actas del V Simposio de Historia Actual: La Rioja, España, Europa. Logroño, Instituto de Estudios Riojanos, 2006, 449 pp.Páginas 208-212Alfonso Pinilla GarcíaEvans, Richard J., La llegada del Tercer Reich. Barcelona, Península, 2005, 672 pp.Páginas 212-214Alejandro Piñero GonzálezFriedman, Thomas L., La Tierra es plana. Breve historia del mundo globalizado del siglo XXI. Madrid, Martínez Roca, 2006, 496 pp.Páginas 214-216David Molina RabadánGil Calvo, Enrique, El miedo es el mensaje. Riesgo, incertidumbre y medios de comunicación. Madrid, Alianza Editorial, 2004, 320 pp.Páginas 216-218Lucía Benítez EyzaguirreGoicovic Donoso, Igor, Entre el dolor y la ira. La venganza de Antonio Ramón Ramón. Chile, 1914. Osorno, Editorial Universidad de los Lagos, 2005, 188 pp.Páginas 218-221Alejandra Brito PeñaGriffin, Roger (ed., Fascism, Totalitarianism and Political Religion. New York, Routledge, 2005, 225 pp.Páginas 221-222Jan NelisMcNeill, John R., Algo nuevo bajo el Sol. Historia medioambiental del mundo en el siglo XX. Alianza

  8. Using DInSAR as a tool to detect unstable terrain areas in an Andes region in Ecuador (South America)

    Science.gov (United States)

    Mayorga Torres, Tannia

    2014-05-01

    deeper into vegetation cover than C band (Raucoules et al., 2007). The study processed ERS with descending orbit and ALOS with ascending orbit, due to the availability of data. Ferretti et al. (2007) said that ERS looks to the right and a slope mainly oriented to the west could have foreshortening effect in ascending orbit. Wei & Sandwell (2010) mention that ALOS in ascending orbit identifies vertical mass movements along fault systems; however, descending data has better geometry to measure mass movements. The study has fewer scenes in descending orbit. For further work, ALOS 2 will let to have more data in descending orbit. 4. CENTRAL CONCLUSIONS For mass movement having high-resolution radar is the best option; however, this data is not useful on all due to cover vegetation. Characterizing mass movements in Ecuador in necessary to put monitoring systems to avoid economic and human lost. Processing ERS and ALOS data was very useful because penetration band results were clearly identified in coherence masks. The result of Stacking DInSAR did not show clearly fringes, indeed the amount of interferograms were no enough for this technique. Researching other DInSAR techniques is necessary due to the singular characteristics of Ecuador. 5. REFERENCES Ferretti Alessandro, Monti-Guarnieri Andrea, Prati Claudio, Rocca Fabio, Massonnet Didier (2007). InSAR Principles: Guidelines for SAR Interferometry Processing and Interpretation (TM-19, Febrero 2007). K. Fletcher, Agencia Espacial Europea Publicaciones. ESTEC. Postbus 2009. 2200 AG Noordwijk. The Netherlands. Raucoules Daniel, Colesanti Carlo, Carnec Claudie (2007). "Use of SAR interferometry for detecting and assessing ground subsidence." C. R. Geoscience 339(289-302): 14. Sandwell David T., Price Evelyn J. (1998). "Phase gradient approach to stacking interferograms." Journal of Geophysical Research 103(N. B12): 30, 183-30, 204. Wei Meng, Sandwell David T (2010). "Decorrelation of L-Band and C-Band Interferometry Over

  9. Normas para colaboração

    Directory of Open Access Journals (Sweden)

    Helmut Renders

    2009-10-01

    da ABNT,2002. Seguem alguns exemplos:Livro:SOBRENOME DO/A AUTOR/A, prenome. Título da obra: subtítulo. Númeroda edição se não for a primeira, Local de publicação, estado: editora, data.RIBEIRO, Claudio de Oliveira et all. (orgs.. Teologia e prática na tradição wesleyena: Uma leitura a partir da América Latina e Caribe. São Bernardo do Campo, SP: Editeo, 2005.Artigo:SOBRENOME DO/A AUTOR/A, prenome. “Título do artigo”. In: Título doperiódico, número da edição, páginas (data.PAULA, Blanches de. “Luto e existência”. In: Caminhando, vol. 11, n. 17, p. 105-114 (2006.Coletânea:SOBRENOME DO/A AUTOR/A, prenome. “Título do capítulo”. In: iniciais do nome seguidas do sobrenome do organizador. Título da coletânea. Número da edição quando não for a primeira. Local de publicação, Estado: editora, data.MENDONÇA, Antonio Gouvêa “Ciência(s da Religião: Teoria e pós-graduação no Brasil”. F. Teixeira. A(s ciência(s da religião no Brasil: afirmação de uma área acadêmica. São Paulo, SP: Paulinas, 2001.Referências da Internet:Acresce-se, depois da citação do livro ou do artigo: Disponível em: . Acesso em: dia[s]/mês/ano (somente números.RAUSCHENBUSCH, Walter. For God and the People. Prayers of the SocialAwakening. Boston, New York, Chicago: The Pilgrim Press, 1910. Disponível em: .Acesso em: 20/03/2009.

  10. GUIDELINES FOR THE DIAGNOSIS AND MANAGEMENT OF SYNCOPE (2009

    Directory of Open Access Journals (Sweden)

    Angel Moya

    2010-01-01

    Full Text Available Внешние эксперты: Haruhiko Abe (Япония, David G. Benditt (США, Wyatt W. Decker (США, Blair P. Grubb (США, Horacio Kaufmann9 (США, Carlos Morillo (Канада, Brian Olshansky (США, Steve W. Parry (Великобритания, Robert Sheldon (Канада, Win K. Shen (СШАЧлены Комитета Европейского общества кардиологов по практическим рекомендациям (ESC Committee for Practice Guidelines: CPG: Alec Vahanian (Председатель (Франция, Angelo Auricchio (Швейцария,Jeroen Bax (Нидерланды, Claudio Ceconi (Италия, Veronica Dean (Франция, Gerasimos Filippatos (Греция, Christian Funck-Brentano (Франция, Richard Hobbs (Великобритания, Peter Kearney (Ирландия, Theresa McDonagh (Великобритания, Keith McGregor (Франция, Bogdan A. Popescu (Румыния, Zeljko Reiner (Хорватия, Udo Sechtem (Германия, Per Anton Sirnes (Норвегия, Michal Tendera (Польша, Panos Vardas (Греция, Petr Widimsky (ЧехияРецензенты: Angelo Auricchio (Координатор от CPG (Швейцария, Esmeray Acarturk (Турция, Felicita Andreotti (Италия, Riccardo Asteggiano (Италия, Urs Bauersfeld (Швейцария, Abdelouahab Bellou4 (Франция, Athanase Benetos6 (Франция, Johan Brandt (Швеция, Mina K. Chung3 (США, Pietro Cortelli 8 (Италия, Antoine Da Costa (Франция, Fabrice Extramiana (Франция, Jose´ Ferro7 (Португалия, Bulent Gorenek (Турция, Antti Hedman (Финляндия, Rafael Hirsch (Израиль, Gabriela Kaliska (Словакия, Rose Anne Kenny6 (Ирландия, Keld Per Kjeldsen (Дания, Rachel Lampert 3 (USA, Henning Mølgard (Denmark, Rain Paju (Эстония, Aras Puodziukynas (Литва, Antonio Raviele (

  11. Study on antibacterial alginate-stabilized copper nanoparticles by FT-IR and 2D-IR correlation spectroscopy

    Directory of Open Access Journals (Sweden)

    Díaz-Visurraga J

    2012-07-01

    Full Text Available Judith Díaz-Visurraga,1,2 Carla Daza,2 Claudio Pozo,2 Abraham Becerra,2 Carlos von Plessing,1,2 Apolinaria García31Department of Pharmacy, Faculty of Pharmacy, University of Concepcion; 2Research Center of Advanced Polymers (CIPA, CONICYT REGIONAL/CIPA R08C1002; 3Department of Microbiology, Faculty of Biological Sciences, University of Concepcion, Concepción, ChileBackground: The objective of this study was to clarify the intermolecular interaction between antibacterial copper nanoparticles (Cu NPs and sodium alginate (NaAlg by Fourier transform infrared spectroscopy (FT-IR and to process the spectra applying two-dimensional infrared (2D-IR correlation analysis. To our knowledge, the addition of NaAlg as a stabilizer of copper nanoparticles has not been previously reported. It is expected that the obtained results will provide valuable additional information on: (1 the influence of reducing agent ratio on the formation of copper nanoparticles in order to design functional nanomaterials with increased antibacterial activity, and (2 structural changes related to the incorporation of Cu NPs into the polymer matrix.Methods: Cu NPs were prepared by microwave heating using ascorbic acid as reducing agent and NaAlg as stabilizing agent. The characterization of synthesized Cu NPs by ultraviolet visible spectroscopy, transmission electron microscopy (TEM, electron diffraction analysis, X-ray diffraction (XRD, and semiquantitative analysis of the weight percentage composition indicated that the average particle sizes of Cu NPs are about 3–10 nm, they are spherical in shape, and consist of zerovalent Cu and Cu2O. Also, crystallite size and relative particle size of stabilized Cu NPs were calculated by XRD using Scherrer’s formula and FT from the X-ray diffraction data. Thermogravimetric analysis, differential thermal analysis, differential scanning calorimetry (DSC, FT-IR, second-derivative spectra, and 2D-IR correlation analysis were applied to

  12. РЕКОМЕНДАЦИИ ПО ЛЕЧЕНИЮ ОСТРОГО КОРОНАРНОГО СИНДРОМА БЕЗ СТОЙКОГО ПОДЪЕМА СЕГМЕНТА ST

    Directory of Open Access Journals (Sweden)

    2012-01-01

    Full Text Available Члены комитета по практическим рекомендациям: Jeroen J. Bax (председатель (Нидерланды, Angelo Auricchio (Швейцария, Helmut Baumgartner (Германия, Claudio Ceconi (Италия, Veronica Dean (Франция, Christi Deaton (Великобритания, Robert Fagard (Бельгия, Christian Funck-Brentano (Франция, David Hasdai (Израиль, Arno Hoes (Нидерланды, Juhani Knuuti (Финляндия, Philippe Kolh (Бельгия, Theresa McDonagh (Великобритания,Cyril Moulin (Франция, Don Poldermans (Нидерланды, Bogdan A. Popescu (Румыния, Zeljko Reiner (Хорватия, Udo Sechtem (Германия, Per Anton Sirnes (Норвегия, Adam Torbicki (Польша, Alec Vahanian (Франция, Stephan Windecker (Швейцария Рецензенты: Stephan Windecker (координатор (Швейцария, Stephan Achenbach (Германия, Lina Badimon (Испания, Michel Bertrand (Франция, Hans Erik Bøtker (Дания, Jean-Philippe Collet (Франция, Filippo Crea (Италия, Nicolas Danchin (Франция, Erling Falk (Дания, John Goudevenos (Греция, Dietrich Gulba (Германия, Rainer Hambrecht (Германия, Joerg Herrmann (США, Adnan Kastrati (Германия, Keld Kjeldsen (Дания, Steen Dalby Kristensen(Дания, Patrizio Lancellotti (Бельгия, Julinda Mehilli (Германия, Bela Merkely (Венгрия, Gilles Montalescot (Франция, Franz-Josef Neumann (Германия, Ludwig Neyses (Великобритания, Joep Perk (Швеция, Marco Roffi (Швейцария, Francesco Romeo (Италия, Mikhail Ruda (Россия, Eva Swahn (Швеция, Marco Valgimigli (Италия, Christiaan JM Vrints (Бельгия, Petr Widimsky (Чешская республика

  13. Homenaje al Profesor Académico Juan Di Doménico.

    Directory of Open Access Journals (Sweden)

    Roberto Vergara Támara

    2004-03-01


    Nápoles en 1924 donde completó su bachillerato Académico en el Liceo Umberto 1. Estudió medicina desde 1931 y se graduó en 1937. En 1938 aprobó los exámenes estatales para ejercer la medicina en Italia.

    Casado con Carmen Buraglia Stella (1947-1992. Sus hijos: Juan Francisco, Cirujano y Claudio Maurizio, Arquitecto, constructor. Sus nietos: Stefano, Eric, Claudia y Valeria.
    Viajó a Estados Unidos, se especializó en Cirugía General. Internado Rotatorio en el Merey Hospital Davenport, lowa, 1939-1940. Se matriculó en un Curso de Cirugía General en el Cook County Graduate School of Medicine, 1939-1941 Yen la Mayo Clinic de Rochester, Minnesota. Asistió además al Columbus Hospital de New York y al Charity Hospital de New Orleans...


  14. РЕКОМЕНДАЦИИ ПО РЕВАСКУЛЯРИЗАЦИИ МИОКАРДА

    Directory of Open Access Journals (Sweden)

    2011-01-01

    Full Text Available Комитет ESC по практическим рекомендациям: Alec Vahanian (председатель (Франция, Angelo Auricchio (Швейцария, Jeroen Bax (Нидерланды, Claudio Ceconi (Италия, Veronica Dean (Франция, Gerasimos Filippatos (Греция, Christian Funck-Brentano (Франция, Richard Hobbs (Великобритания, Peter Kearney (Ирландия, Theresa McDonagh (Великобритания, Bogdan A. Popescu (Румыния, Zeljko Reiner (Хорватия, Udo Sechtem (Германия, Per Anton Sirnes (Норвегия, Michal Tendera (польша, Panos E. Vardas (Греция, Petr Widimsky (Чешская республикаКомитет EACTS по клиническим рекомендациям: Philippe Kolh (председатель (Бельгия, Ottavio Alfieri (Италия, Joel Dunning (Великобритания, Stefano Elia (Италия, Pieter Kappetein (Нидпрланды, Ulf Lockowandt (Швеция, George Sarris (Греция, Pascal Vouhe (ФранцияРецензенты: Peter Kearney (координатор от Комитета ЕОК по практическим рекомендациям (Ирландия, Ludwig von Segesser (координатор от EACTS (Швейцария, Stefan Agewall (Норвегия, Alexander Aladashvili (Грузия, Dimitrios Alexopoulos (Греция, Manuel J. Antunes (Португалия, Enver Atalar (Тур-ция, Aart Brutel de la Riviere (Нидерланды, Alexander Doganov (Болгария, Jaan Eha (Эстония, Jean Fajadet (Франция, Rafael Ferreira (Португалия, Jerome Garot (Франция, Julian Halcox (Великобритания, Yonathan Hasin (Израиль, Stefan Janssens (Бельгия, Kari Kervinen (Финляндия, Gunther Laufer (Австрия, Victor Legrand (Бельгия, Samer A.M. Nashef (Великобритания, Franz

  15. Physics in one dimension

    Science.gov (United States)

    van Houselt, A.; Schäfer, J.; Zandvliet, H. J. W.; Claessen, R.

    2013-01-01

    Pashkin, C A Kuntscher, S G Ebbinghaus, M Hanfland, F Lissner, Th Schleid and M Dressel Photoemission spectroscopy and the unusually robust one-dimensional physics of lithium purple bronzeL Dudy, J D Denlinger, J W Allen, F Wang, J He, D Hitchcock, A Sekiyama and S Suga Luttinger liquid behaviour of Li0.9Mo6O17 studied by scanning tunnelling microscopyT Podlich, M Klinke, B Nansseu, M Waelsch, R Bienert, J He, R Jin, D Mandrus and R Matzdorf Mn-silicide nanostructures aligned on massively parallel silicon nano-ribbonsPaola De Padova, Carlo Ottaviani, Fabio Ronci, Stefano Colonna, Bruno Olivieri, Claudio Quaresima, Antonio Cricenti, Maria E Dávila, Franz Hennies, Annette Pietzsch, Nina Shariati and Guy Le Lay Iridium silicide nanowires on Si(001) surfacesNuri Oncel and Dylan Nicholls Structure and growth of quasi-one-dimensional YSi2 nanophases on Si(100)V Iancu, P R C Kent, S Hus, H Hu, C G Zeng and H H Weitering Metallic rare-earth silicide nanowires on silicon surfacesMario Dähne and Martina Wanke One-dimensional collective excitations in Ag atomic wires grown on Si(557)U Krieg, C Brand, C Tegenkamp and H Pfnür Interfering Bloch waves in a 1D electron systemR Heimbuch, A van Houselt, M Farmanbar, G Brocks and H J W Zandvliet Au-induced quantum chains on Ge(001)—symmetries, long-range order and the conduction pathC Blumenstein, S Meyer, S Mietke, J Schäfer, A Bostwick, E Rotenberg, R Matzdorf and R Claessen

  16. List of Participants

    Science.gov (United States)

    2007-11-01

    Mohab Abou ZeidVrije Universiteit, Brussel Joke AdamKatholieke Universiteit Leuven Nikolas AkerblomMax-Planck-Institut für Physik, München Luis Fernando Alday Utrecht University Stelios Alexandris University of Patras Antonio Amariti Università di Milano-Bicocca Nicola Ambrosetti Université de Neuchâtel Pascal Anastasopoulos Università di Roma Tor Vergata Laura Andrianopoli Enrico Fermi Center Carlo Angelantonj Università di Torino Lilia Anguelova Queen Mary, University of London Daniel AreanUniversidade de Santiago de Compostela Gleb ArutyunovUtrecht University Spyros Avramis NTU Athens—University of Patras Ioannis Bakas University of Patras Subrata Bal Dublin Institute for Advanced Studies Igor Bandos Valencia University Jessica Barrett University of Iceland Marco Baumgartl Eidgenössische Technische Hochschule, Zürich Jacopo Bechi Università di Firenze James Bedford Queen Mary, University of London Jorge Bellorin Universidad Autonoma de Madrid Francesco Benini SISSA, Trieste Eric Bergshoeff Centre for Theoretical Physics, University of Groningen Gaetano BertoldiUniversity of Wales, Swansea Adel Bilal Laboratoire de Physique Théorique, École Normale Superieure, Paris Matthias Blau Université de Neuchâtel Johannes BroedelUniversität Hannover Felix Brümmer Universität Heidelberg Julio Cesar Bueno de Andrade São Paulo State University—UNESP Cliff Burgess McMaster University Agostino Butti Laboratoire de Physique Théorique, École Normale Superieure, Paris Marco Caldarelli Universitat de Barcelona Pablo G Camara Centre de Physique Théorique, École Polytechnique, Palaiseau Joan Camps Universitat de Barcelona Felipe Canoura FernandezUniversidade de Santiago de Compostela Luigi Cappiello Università di Napoli Federico II Luca Carlevaro École Polytechnique, Palaiseau Roberto Casero Centre de Physique Théorique, École Polytechnique, Palaiseau Claudio Caviezel Max-Planck-Institut für Physik, München Alessio Celi Universitat de Barcelona Anna

  17. Editorial

    Directory of Open Access Journals (Sweden)

    Clarice Helena de Miranda Coimbra

    2015-01-01

    de Janeiro, campus Paracambi. O segundo artigo intitulado “Um breve panorama sobre o léxico em linguística cognitiva”, é de autoria de Caio Cesar Castro da Silva, que apresenta uma introdução aos estudos lexicais de base cognitiva. O terceiro artigo intitulado “Estudo teórico do sufixo nominalizador –ura: como descrevê-lo?” é de autoria de Ana Carolina Mrad de Moura Valente, que levou em consideração os diversos estudos em língua portuguesa sobre nominalização e apresentou em seu artigo, um levantamento dos estudos sobre o sufixo –ura em português. O quarto artigo de autoria de Nilton Rodrigues Junior, intitula-se “Pastoras na voz, insubmissas na vida? As mulheres da velha guarda da Portela”, o qual procurou interpretar as relações de gênero entre os integrantes do grupo partindo do entendimento do lugar social das pastoras. O quinto artigo é de autoria de Claudio Alberto Mendes Gomes que tem como título “A importância do conceito de razão na perspectiva de Pascal em breve comparação com o pensamento cartesiano”, procurando o autor demonstrar teoricamente como se construiu o conceito de razão pascalino difundido nos séculos XVI e XVII. Apresentamos o sexto artigo de autoria de Bruno dos Santos Silva, intitulado “O conceito de psicopatia analisado pela criminologia crítica”. Em seu artigo o autor investiga o conceito de psicopatia, ainda no século XIX até os dias atuais, utilizando construções da Criminologia para interpretar a conformação do objeto psicopatia e que repercussões institucionais ela pode trazer. O sétimo artigo “A água como bem jurídico econômico”, é de autoria de Natacha Zanghelini Borba e de Diego Augusto Bayer; aqui, seus autores procuraram apresentar as principais mudanças das leis para a cobrança da água, bem como demonstrar a escassez desse recurso no mundo e no Brasil. No oitavo artigo, Thamyrys Baur Tuffi Alli, apresenta como título “Responsabilização criminal da pessoa

  18. Programa de Pós-Graduação em Geologia - Dissertações Defendidas 1999 - Mestrado - Instituto de Geociências - Universidade Federal do Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    1999-01-01

    é então conhecidas. Os taxa identificados são concordantes com a idéia vigente de que as condições climáticas, ambientais e ecológicas eram diferentes dos atualmente reinantes no nordeste brasileiro durante o Pleistoceno final sub-recente, quando prevalecia um ambiente semi-árido mais ameno. Nome: Francisco Crescêncio Júnior Orientador: Claudio Gerhiem Porto Título: Estudomorfológico e Químico dos Grãos de Ouro do Minério Oxidado da Mina de Roça Grande Ii, Mg Resumo: A partir do final da década de 70 e nos anos 80, graças ao aumento do preço do ouro, intensificaram-se as pesquisas relacionadas ao comportamento deste metal em ambientes supergênicos. Várias pesquisas se desenvolveram na Austrália, África e Brasil, voltadas, principalmente, para os depósitos supergênicos lateríticos, onde se verificou que o ouro pode sofrer remobilização, através de processos químicos e físicos. A área do presente estudo, Mina de Roça Grande II, situa-se no Quadrilátero Ferrífero, MG. O depósito encaixa-se nos metassedimentos químicos do Grupo Nova Lima. Tanto o estudo da morfologia dos grãos de ouro com auxílio de lupa binocular e microscópio eletrônico de varredura (MEV acoplado a um analisador de imagem quanto da composição química destes grãos com auxílio da microssonda eletrônica, visou elucidar a atuação de tais processos. Na zona oxidada da mina foram estudados os níveis de saprock e saprolito na formação ferrífera e no metachert, além de um nível de solo coluvionar. Estes horizontes caracterizam um perfil intempérico típico de regiões de altitudes elevadas e de natureza supergênica não-laterítica. O estudo da morfologia dos grãos de ouro revelou que os grãos do solo tendem a ser mais regulares, lisos e arredondados, demonstrando maior desgaste em relação aos grãos encontrados nos outros horizontes. O analisador de imagem, apesar de diferenciar grãos regulares e irregulares, confirmando as observações de lupa

  19. 5th National Congress of the Italian Society of Physiotherapy

    Directory of Open Access Journals (Sweden)

    Alessandro Aina

    2016-10-01

    knee prosthesis Cislaghi M, Penone G, Marinelli G, Rezzan G, Melegati G, Gatti R P14 The use of Kinesio Taping in the treatment of hematomas: can we distinguish fancy from the effects? Colombo Claudio, Tolosa Francesca, Andrea Moriondo, Vercelli Stefano P15 Who is able to perform explicit motor imagery after stroke? Stefano Doronzio, Matteo Paci P16 Responsiveness of the Bridge tests in Symptomatic Lumbar Spondylolisthesis Silvano Ferrari, Carla Vanti, Marco Monticone P17 The relationship between number of sessions and clinical results in lumbar symptomatic spondylolisthesis Silvano Ferrari, Carla Vanti, Marco Monticone P18 Conservative treatments for upper extremity tendinopathies in occupational medicine: narrative review Garzonio Fabiola, Zanetta Anna, Bargeri Serena, Cerone Giorgia, Sartorio Francesco P19 The time-related effect of roller-massager on extensibility of the hamstring muscles Filippo Ghirlanda, Alessandro Schneebeli, Corrado Cescon, Marco Barbero P20 Effect of two different exercise programs on pain, disability and quality of life in people with subacute and chronic nonspecific neck pain Gioia G, Faccendini S, Aina A, Tettamanti A P21 A bridge between clinical practice and research: how health professionals can study literature and learn on the job Granzotto G, Coppola L, Gava I, Frassinelli M, Gattinoni F P22 Walking capacity improves after neuromotor physiotherapy in stroke patients Lorenzo Guidotti, Marco Postiglione, Bruna Lombardi, Matteo Paci P23 Intra and inter-session reliability of the angle between pain onset and submaximal pain during upper limb neurodynamics test 1: a study in healty individuals Diego Leoni, Davide Storer, Roberto Gatti, Michele Egloff, Marco Barbero P24 Effects of an AO-MI training on balance task in patients affected by multiple sclerosis Magno Tiziano, Tettamanti Andrea P25 Outcomes of treatment with neuromuscular stimulator for chronic anterior knee pain: a clinical case Daniele Maremmani, Sebastiano Cencini, Giuseppe

  20. PREFACE: Fourth Meeting on Constrained Dynamics and Quantum Gravity

    Science.gov (United States)

    Cadoni, Mariano; Cavaglia, Marco; Nelson, Jeanette E.

    2006-04-01

    ) Georgi Dvali (NYU, USA) Sergio Ferrara (CERN) Gian Francesco Giudice (CERN) Roman Jackiw (MIT, USA) Edward W. Kolb (Fermilab, USA) Luca Lusanna (INFN Firenze, Italy) Roy Maartens (Univ. Portsmouth, UK) Hermann Nicolai (AEI, Potsdam, Germany) Tullio Regge (Politecnico di Torino, Italy) Augusto Sagnotti (Univ. Roma Tor Vergata, Italy) Kellogg S. Stelle (Imperial College London, UK) Ruth Williams (DAMTP, Cambridge, UK) SPONSORS Istituto Nazionale di Fisica Nucleare Università di Cagliari Università di Torino University of Mississippi Università di Pisa Regione autonoma della Sardegna Tiscali LIST OF PARTICIPANTS Eun-Joo Ahn (University of Chicago, USA) David Alba (Università di Firenze, Italy) Stanislav Alexeyev (Lomonosov Moscow State U., Russia) Damiano Anselmi (Università di Pisa, Italy) Ignatios Antoniadis (CERN, Geneva, Switzerland) Maria Da Conceicao Bento (Instituto Superior Técnico, Lisboa, Portugal) Orfeu Bertolami (Instituto Superior Técnico, Lisboa, Portugal) Massimo Bianchi (Università di Roma Tor Vergata, Italy) Mariam Bouhmadi-Lopez (University of Portsmouth, UK) Raphael Bousso (University of California at Berkeley, USA) Mariano Cadoni (Università di Cagliari, Italy) Steven Carlip (University of California at Davis, USA) Roberto Casadio (Università di Bologna, Italy) Marco Cavaglià (University of Mississippi, USA) Demian Cho (Raman Research Institute, Bangalore, India) Theodosios Christodoulakis (University of Athens, Greece) Chryssomalis Chryssomalakos (Inst. de Ciencias Nucleares - UNAM, Mexico) Diego Julio Cirilo-Lombardo (JINR, Dubna, Russia) Denis Comelli INFN, Sezione di Ferrara, Italy ) Ruben Cordero-Elizalde (Instituto Politecnico Nacional, Mexico) Lorenzo Cornalba (Università di Roma Tor Vergata, Italy) Branislav Cvetkovic (Institute of Physics, Belgrade, Serbia ) Maro Cvitan (University of Zagreb, Croatia) Alessandro D'Adda (Università di Torino, Italy) Claudio Dappiaggi (Università di Pavia, Italy) Roberto De Leo (Università di

  1. Programa de Pós Graduação em Ciências Atmosféricas em Engenharia - 2005 -Teses Defendidas - Doutorado - Instituto de Geociências - UFRJ

    Directory of Open Access Journals (Sweden)

    2005-01-01

    campo. As metodologias para a estimativa da TST são apresentadas e seus resultados discutidos. Os melhores resultados foram obtidos pelas metodologias de França (1994 e de Bastiaanssen (1995 que apresentaram erros médios de estimativa iguais a 0,2oC e 0,6oC, respectivamente. Autor: Audalio Rebelo Torres Junior Orientadores: Claudio Freitas Neves (COPPE e Affonso da Silveira Mascarenhas Junior Título: Estudo numérico sobre tele-conexão atmosférica entre fenômenos oceânicos do Pacífico Equatorial e do Atlântico Sul No de páginas: 147 Resumo Neste trabalho é demonstrado como, nas escalas sazonal e interanual, a Alta Subtropical do Atlântico Sul em resposta às anomalias de temperatura da superfície do mar no Pacífico equatorial e via circulação de Walker e Hadley, influencia a profundidade e conseqüentemente a disponibilidade da Água Central do Atlântico Sul ao bombeamento de Ekman, na bacia sudoeste do Atlântico Sul. Foram utilizados dados das reanálises do National Center for Environmental Prediction e do experimento de assimilação de dados do Geophysical Fluid Dynamics Laboratory, bem como realizadas simulações da atmosfera em escala global, aplicando o Community Climate Model do National Center for Atmopheric Research e, simulações oceânicas em escala de bacia com o Princeton Ocean Model. Os resultados dos modelos mostraram alterações no padrão de circulação das células de Hadley e Walker, implicando no comportamento da Alta Subtropical do Atlântico. O Oceano respondeu com aumento do transporte da Corrente do Brasil e intensificação da corrente das Malvinas. A ACAS ficou mais rasa respondendo à variação do balanço de Sverdrup. Autor: Gevaldo Lisboa de Almeida Orientadores: Renato Machado Cotta e Luiz Cláudio Gomes Pimentel Título: Análise da dispersão de poluentes na atmosfera usando a técnica da transformada integral generalizada No de páginas: 165 215 Programa de Pós Graduação em Ciências Atmosféricas em

  2. Programa de Pós-Graduação em Geologia - Dissertações Defendidas 2001 - Mestrado - Instituto de Geociências - Universidade Federal do Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    2001-01-01

    Full Text Available 40 Anuário do Instituto de Geociências - UFRJ Volume 24 / 2001 Programa de Pós-Graduação em Geologia Dissertações Defendidas - Mestrado Nome: Aline Theophilo Silva Orientadores: Claudio Limeira Mello, Cláudio Coelho de Lima e Hélio Maurício Ribeiro dos Santos Título: Um estudo da influência do estado de tensões in-situ sobre a estabilidade de poços Resumo: O conhecimento do estado de tensões in-situ é um fator fundamental para diversas atividades da explotação na indústria do petróleo. Tal conhecimento gera subsídios para projetos de poços direcionais e de fraturamento hidráulico, previsão de produção de areia e de várias outras atividades. Com base na premissa de que as bacias da margem atlântica brasileira são tectonicamente relaxadas, o planejamento de atividades de explotação no Brasil é usualmente feito assumindo-se que as tensões horizontais principais são iguais e dependem somente da tensão de sobrecarga. Entretanto, compilações do estado de tensões em escala mundial, feitas no contexto do WORLD STRESS MAP (Zoback, 1992, indicam que esta premissa pode não ser correta, visto que a tensão principal máxima é horizontal em muitas partes do mundo. No Brasil, trabalhos baseados em sismologia e na análise da magnitude de tensões obtidas a partir de fraturamentos hidráulicos e de testes de leak-off disponíveis em várias bacias têm mostrado que usualmente a maior das tensões principais é horizontal. Nesta tese, fezse um estudo do estado de tensões in-situ num campo de petróleo utilizando-se: análise de breakouts, para a determinação da orientação das tensões horizontais in-situ; testes de leak-off obtidos de poços verticais e testes de leak-off obtidos de poços direcionais (usados na inversão de leak-off, para estimar-se as magnitudes das tensões horizontais in-situ. O tensor de tensões calculado pela inversão de leak-off reproduziu a orientação das tensões horizontais obtida atrav

  3. Programa de Pós-Graduação em Geologia - Teses Defendidas 2000 - Doutorado - Instituto de Geociências - UFRJ

    Directory of Open Access Journals (Sweden)

    2000-01-01

    braquiúres foi soterrada após sua morte (posição normal, embora 25% deles represente indivíduos que foram surpreendidos pelo soterramento (posição de escape. A maioria dos cadáveres com o tórax intacto indica que os processos de decomposição foram interrompidos com a formação das concreções. Foram individualizadas quatro morfologias nos carcinólitos, a saber: prolatos, arredondados, bifurcados e cintados. Nos dois primeiros tipos ocorrem apenas um indivíduo em seu interior, enquanto que nos demais são encontradas partes morfológicas de indivíduos diferentes. A espessura da concreção é função direta da duração dos processos de decomposição. As feições diagenéticas sugerem que os carcinólitos se formaram segundo a seguinte seqüência de etapas: dissolução, recristalização, fosfatização, silicificação e compressão. Em algumas concreções os braquiúres estão expostos em sua superfície. Esta feição representa ação erosiva por transporte fluvial ou ação de marés, que causou abrasão e corrosão dos carcinólitos, sendo considerada portanto, uma feição pós-diagenética. A presença de microfósseis marinhos, e de formas jovens e adultas, algumas desarticuladas e fragmentadas, de braquiúres na paleotafocenose, sugerem um evento de mortandade em massa. A ausência de dados faciológicos das rochas encaixantes dos carcinólitos, torna difícil inferir as causas desse evento catastrófico. Entretanto, pode-se sugerir que ondas de tempestade podem ter provocado remoção do fundo lamoso rico em H2S, e causado a morte dos organismos por envenenamen- 36 Anuário do Instituto de Geociências - UFRJ Volume 23 / 2000 to. A posição de soterramento de alguns exemplares de Uca maracoani pode refletir a ação de correntes de lama, que causou soterramento destes, antes de sua morte. Nome: Miguel Armony Orientador: Claudio Bettini Título: Geoestatística paramétrica de campo Resumo: Muitas técnicas foram introduzidas ao longo do

  4. EDITORIAL: Colloidal dispersions in external fields Colloidal dispersions in external fields

    Science.gov (United States)

    Löwen, Hartmut

    2012-11-01

    , Ojeda-Lopez M A and Arauz-Lara J L 2012 J. Phys. Condens. Matter 24 464126 [31]Leferink op Reinink A B G M, van den Pol E, Byelov D V, Petukhov A V and Vroege G J 2012 J. Phys. Condens. Matter 24 464127 [32]Taylor S L, Evans R and Royall C P 2012 J. Phys. Condens. Matter 24 464128 [33]Toner J, Tu Y H and Ramaswamy S 2012 J. Phys. Condens. Matter 24 464110 [34]Schmitz R and Dünweg B 2005 J. Phys. Condens. Matter 318 170 [35]Cates M E 2012 Rep. Prog. Phys. 75 042601 [36]Tarama M and Ohta T 2012 J. Phys. Condens. Matter 24 464129 [37]Wensink H H and Löwen H 2012 J. Phys. Condens. Matter 24 464130 Colloidal dispersions in external fields contents Colloidal dispersions in external fieldsHartmut Löwen Depletion induced clustering in mixtures of colloidal spheres and fd-virusD Guu, J K G Dhont, G A Vliegenthart and M P Lettinga Advanced rheological characterization of soft colloidal model systemsS Gupta, S K Kundu, J Stellbrink, L Willner, J Allgaier and D Richter Conformational and dynamical properties of ultra-soft colloids in semi-dilute solutions under shear flowSunil P Singh, Dmitry A Fedosov, Apratim Chatterji, Roland G Winkler and Gerhard Gompper Transient dynamics in dense colloidal suspensions under shear: shear rate dependenceM Laurati, K J Mutch, N Koumakis, J Zausch, C P Amann, A B Schofield, G Petekidis, J F Brady, J Horbach, M Fuchs and S U Egelhaaf Force-induced diffusion in microrheologyCh J Harrer, D Winter, J Horbach, M Fuchs and Th Voigtmann Micro-macro-discrepancies in nonlinear microrheology: I. Quantifying mechanisms in a suspension of Brownian ellipsoidsRyan J DePuit and Todd M Squires Micro-macro discrepancies in nonlinear microrheology: II. Effect of probe shapeRyan J DePuit and Todd M Squires Viscosity of electrolyte solutions: a mode-coupling theoryClaudio Contreras-Aburto and Gerhard Nägele Electro-kinetics of charged-sphere suspensions explored by integral low-angle super-heterodyne laser Doppler velocimetryThomas Palberg, Tetyana K

  5. List of Participants

    Science.gov (United States)

    2008-11-01

    Davide CassaniLaboratoire de Physique Théorique, École Normale Supérieure, Paris Alejandra CastroUniversity of Michigan Claudio Caviezel Max-Planck-Institut für Physik, München Alessio Celi Universitat de Barcelona Anna Ceresole Istituto Nazionale di Fisica Nucleare, Università di Torino Athanasios ChatzistavrakidisNational Technical University of Athens Wissam ChemissanyCentre for Theoretical Physics, University of Groningen Eugen-Mihaita CioroianuUniversity of Craiova Andres CollinucciTechnische Universität Wien Paul CookUniversità di Roma, Tor Vergata Lorenzo CornalbaUniversità di Milano-Bicocca Aldo CotroneKatholieke Universiteit Leuven Ben Craps Vrije Universiteit, Brussel Stefano Cremonesi SISSA, Trieste Riccardo D'AuriaPolitecnico di Torino Gianguido Dall'AgataUniversity of Padova Jose A de AzcarragaUniversidad de Valencia Jan de BoerInstituut voor Theoretische Fysica, Universiteit van Amsterdam Sophie de BuylInstitut des Hautes Études Scientifiques, Bures-sur-Yvette Marius de LeeuwUtrecht University Frederik De RooVrije Universiteit, Brussel Jan De Rydt Katholieke Universiteit Leuven and CERN, Geneva Bernard de WitInstitute for Theoretical Physics, Utrecht University Stephane DetournayIstituto Nazionale di Fisica Nucleare, Sezione di Milano Paolo Di Vecchia Niels Bohr Institute, København Eugen DiaconuUniversity of Craiova Vladimir Dobrev Institute for Nuclear Research and Nuclear Energy, Bulgarian Academy of Sciences, Sofia Nick DoreyUniversity of Cambridge Hajar Ebrahim NajafabadiIPM, Tehran Federico Elmetti Università di Milano Oleg Evnin Vrije Universiteit, Brussel Francesco Fiamberti Università di Milano Davide Forcella SISSA, Trieste and CERN, Geneva Valentina Forini Humboldt-Universität zu Berlin Angelos Fotopoulos Università di Torino Denis Frank Université de Neuchâtel Marialuisa Frau Università di Torino Matthias Gaberdiel Eidgenössische Technische Hochschule (ETH), Zürich Diego Gallego SISSA/ISAS, Trieste Maria Pilar Garcia del

  6. Undercover Stars Among Exoplanet Candidates

    Science.gov (United States)

    2005-03-01

    is only 16% larger than this giant planet! A Dense Star "Imagine that you add 95 times its own mass to Jupiter and nevertheless end up with a star that is only slightly larger", suggests Claudio Melo from ESO and member of the team of astronomers who made the study. "The object just shrinks to make room for the additional matter, becoming more and more dense." The density of such a star is more than 50 times the density of the Sun. "This result shows the existence of stars that look strikingly like planets, even from close by", emphasizes Frederic Pont of the Geneva Observatory (Switzerland). "Isn't it strange to imagine that even if we were to receive images from a future space probe approaching such an object at close range, it wouldn't be easy to discern whether it is a star or a planet?" As all stars, OGLE-TR-122b produces indeed energy in its interior by means of nuclear reactions. However, because of its low mass, this internal energy production is very small, especially compared to the energy produced by its solar-like companion star. Not less striking is the fact that exoplanets which are orbiting very close to their host star, the so-called "hot Jupiters", have radii which may be larger than the newly found star. The radius of exoplanet HD209458b, for example, is about 30% larger than that of Jupiter. It is thus substantially larger than OGLE-TR-122b! Masqueraders ESO PR Photo 06c/05 ESO PR Photo 06c/05 Comparison Between OGLE-TR-122b, Jupiter and the Sun [Preview - JPEG: 400 x 598 pix - 30k] [Normal - JPEG: 800 x 1196 pix - 350k] [HiRes - JPEG: 5000 x 3344 pix - 2.2M] Caption: ESO PR Photo 06c/05 is a comparison between the newly found low-mass star OGLE-TR-122b and the Sun and Jupiter. OGLE-TR-122b, while still 96 times as massive as Jupiter, is only 16% larger than this giant planet. It weighs 1/11th the mass of the Sun and has 1/8th of its diameter. (credits: Sun image: SOHO/ESA; Jupiter: Cassini/NASA/JPL/University of Arizona/ESA) This discovery also

  7. Programa de Pós-Graduação em Geografia - Dissertações Defendidas 2000 - Mestrado - Instituto de Geociências - UFRJ

    Directory of Open Access Journals (Sweden)

    2000-01-01

    frontais. Nesse contexto, o estudo teve por objetivo geral caracterizar o balanço sedimentar em um trecho do cordão de dunas frontais adjacentes à praia de Massambaba. a metodologia desenvolvida teve por base o monitoramento do campo de dunas frontais durante 22 meses (09.03.1996 a 31.12.1997 onde foram empregadas técnicas de levantamento topográfico, coleta de areia em armadilhas e análise sedimentológica, que associadas ao comportamento climatológico do período, permitiram definir um comportamento sedimentar para as dunas frontais. Nome: Analia Margarita Romanello Orientador: Claudio Antonio Gonçalves Egler Título: Aplicação de sistema de informações geográficas (SIG na avaliação da qualidade de vida 42 Anuário do Instituto de Geociências - UFRJ Volume 23 / 2000 Resumo: Na última década, a tecnologia dos Sistemas de Informação Geográfica (SIGs ganhou prestígio como ferramenta moderna para o manejo da informação espacial aplicável aos estudos do território. As propriedades que caracterizam os SIGs podem contribuir para alcançar novos conhecimentos através da análise de dados e informação sobre o território, quer dizer, sobre a organização e o funcionamento do espaço geográfico. Sem dúvida, a complexidade que estes processos apresentam e as dificuldades ou inconveniências que acarreta o emprego de técnicas computacionais, colocam o debate acerca de sua correta aplicação e das limitações que surgem na implementação da tecnologia dos SIGs como contribuição aos estudos territoriais. O emprego de técnicas de geoprocessamento como ferramenta de avaliação, no entanto é ainda limitado, sobretudo se comparamos com sua potencialidade. Este fato se deve tanto a falta de domínio dos métodos destas ferramentas, como também às dificuldades de obtenção de dados confiáveis para uso em SIG. Assim, em cada novo avanço, a tecnologia oferece maiores possibilidades para atingir e usar o conhecimento sobre o território e para faz

  8. Programa de Pós-Graduação em Geografia - Teses Defendidas 2001- Doutorado - Instituto de Geociências - Universidade Federal do Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    2001-01-01

    Full Text Available 35 Anuário do Instituto de Geociências - UFRJ Volume 24 / 2001 Nome: Cesar Ajara Orientador: Bertha K. Becker Título: Brasil: Espaços incluídos e espaços excluídos na dinâmica da geração de riqueza. Resumo: Esta tese analisa o impacto das forças globalizadoras na reelaboração do espaço geográfico nacional, no período 1980-1996, procurando identificar a existência de uma nova configuração espacial atrelada à dinâmica econômico-espacial do país. Nesse sentido, associa a inclusão/exclusão de espaços mesorregionais à lógica da competitividade e seletividade espacial. Dentre os resultados alcançados, evidencia a emergência de operação de um movimento reconcentrador do crescimento econômico nos espaços hegemônicos da economia e a fragmentação do crescimento nas áreas periféricas a esses espaços. Identifica espaços incluídos, espaços excluídos e espaços de indefinição, como configuração espacial associada aos processos em curso no final do século XX. Conclui, destacando o quadro de acentuação de assimetrias quanto à capacidade mesorregional de produção, num país de dimensões continentais e marcado por grande heterogeneidade social, econômica e espacial. Visando a contribuir para a elaboração de conhecimento acerca da fase atual de reorganização do espaço nacional, o estudo identifica a existência de Brasis e indica uma agenda para pesquisas futuras neste campo de investigação. Nome: Marcelo Vinicius de La Rocha Domingues Orientador: Claudio Antonio Gonçalves Egler Título: Logística e transporte marítimo internacional: Impactos sobre o sistema Programa de Pós-Graduação em Geografia Teses Defendidas - Doutorado 36 Anuário do Instituto de Geociências - UFRJ Volume 24 / 2001 portuário brasileiro Resumo: A finalidade desta tese de doutorado é apresentar um modelo teórico interpretativo, à luz das novas teorias vigentes na Física, Química, Biologia e Matemática, sobre a rela

  9. Programa de Pós-Graduação em Geologia - Dissertações Defendidas 1998 - Mestrado - Instituto de Geociências - Universidade Federal do Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    1998-01-01

    Full Text Available 106 Programa de Pós-Graduação em Geologia Dissertações Defendidas - Mestrado Nome: Cristiane Mendes Coelho Título: Análise Técnica-Econômica-Financeira de Projetos em Rochas Ornamentais no Município do Rio de Janeiro e Região Metropolitana - Estudos de Casos Orientador: Claudio Margueron Resumo: O processo de avaliação técnica-econômica-financeira de projetos em rochas ornamentais, envolve uma série de análises a serem consideradas. A descrição de alguns aspectos sobre a indústria em questão, com reservas e produção de rochas ornamentais, demanda de produtos, mercado interno e externo e programas de incentivo ao setor tentam situar as empresas em análise no seu contexto setorial. Uma descrição geral sobre o processo produtivo de rochas ornamentais, desde a extração de blocos em pedreiras até a fabricação de peças acabadas, mostra os principais métodos de extração e beneficiamento utilizados nessa indústria. Os estudos de casos serviram de base de dados para a avaliação técnicaeconômica- financeira de projetos a serem desenvolvidos no setor. A estrutura organizacional e infra-estrutura das empresas analisadas são descritas com enfoque para a linha de produção de beneficiamento primário (produção de chapas de granito. São destacados os aspectos técnicos de cada empresa durante o processo produtivo de chapas, como eficiência, desdobramento, velocidade de corte e consumo de insumos em cada caso. A implantação de tecnologia de serragem de blocos sugerida pelo SENAI-DN, surge como uma alternativa de diminuir os problemas detectados nas empresas em questão. São analisados em termos comparativos, os resultados obtidos com a aplicação desta nova tecnologia em relação a metodologia aplicada nas empresas. Devido a ausência de sistemas de custeio adequados para a medição dos resultados econômicos do processo de serragem, foi construído um sistema de custeio pleno com o objetivo de avaliar o custo

  10. Programa de Pós-Graduação em Geografia - Dissertações Defendidas 1999 - Mestrado - Instituto de Geociências - Universidade Federal do Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    1999-01-01

    rio Paquequer (l35,18 km2, onde situa-se a cidade de Teresópolis-RJ. Avalia o comportamento da rede fluvial no processo de ocupação da cidade, ao longo de 41 anos (1956 a 1996, considerando o crescimento de áreas impermeáveis e os problemas na rede fluvial decorrentes dessa expansão. Analisa, em detalhe, a rede de drenagem da sub-bacia do rio Meudon (3ª. Ordem, exemplificadora das mudanças na geometria do canal e nas condições de drenagem. O trabalho foi dividido em 3 (três itens. A caracterização do ambiente da bacia, relevante para as mudanças das condições de drenagem, foi realizada através do inventário dos elementos que condicionam, direta e/ou indiretamente, a rede de drenagem (relevo, geologia, solo, clima, vegetação, ocupação e uso do solo. A seguir, foi avaliada rede de drenagem quanto às suas características morfológicas (hierarquia e morfometria quanto ao perfil longitudinal e aos valores de vazão. O terceiro tópico trata dos efeitos do crescimento urbano sobre os canais de terceira ordem, especialmente quanto as mudanças das condições da geometria dos canais na sub-bacia do rio Meudon. Foi avaliado o crescimento espacial da cidade através da comparação entre fotos aéreas de 1956, 1966, 1976 e imagem SPOT, de 1996. Os resultados mostraram que a dinâmica fluvial, na área urbana de Teresópolis, encontra-se bastante modificada, em especial, no que se relaciona à geometria dos canais e ao escoamento das águas, tendo em vista o crescimento da população e as modificações introduzidas. 130 Anuário do Instituto de Geociências - UFRJ Volume 22 / 1999 Nome: Pierre Alves Costa Orientador: Claudio Antonio Gonçalves Egler Título: A Geografia da Indústria de Química Fina da Região Metropolitana do Rio de Janeiro, Um Estudo de Caso: O Pólo de Química Fina de Jacarepaguá (RJ Resumo: A presente dissertação propõe-se a uma reflexão crítica sobre a Geografia da Indústria de Química Fina na Região Metropolitana do