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Sample records for class iii dentofacial

  1. Surgical-orthodontic correction of a Class III dentofacial deformity

    Directory of Open Access Journals (Sweden)

    Raghu Devanna

    2010-01-01

    Full Text Available This case report describes the surgical-orthodontic treatment of a 26-year-old post-pubertal male patient with a Class III dentofacial deformity. In the pre-surgical orthodontic phase of treatment, a reverse overjet of 5.5 mm was created and arch compatibility was obtained. A mandibualr set back with BSSO was performed during surgery to restore ideal overjet, overbite, occlusion and optimal esthetics. After 1 year of treatment, the results remained stable.

  2. [Effect of extraoral facemask appliance in 48 cases of malocclusion and dentofacial deformity in class III].

    Science.gov (United States)

    Zhang, X; Su, X

    1993-10-01

    Malocclusion and dentofacial deformity in class III is always characterized by maxillary skeletal retrusion and/or mandibular protrusion. It affects function and facial esthetics. An orthopedic mask appliance with class III extraoral traction made by the authors was applied in 48 cases from Aug. 1985 to Oct. 1991. The study population included 5 patients with deciduous dentition, 30 with permanent dentition, and 13 with mixed dentition. The second deciduous molars or permanent first molars are a class III relationship. These exhibited bilateral crossbites and negative overjet greater than 5 mm severe arch length discrepancies existed in both arches, maxillary skeletal retrusion and/or mandibular protrusion. The results of these 48 cases were very satisfactory. The relationship between maxillary and mandibular second deciduous molar or permanent first molar all showed centric occlusal position. Dentofacial orthopedics therapy is one of the most important treatments of malocclusion and dentofacial deformity. The choice of therapy and orthodontic force must follow the age and endurance of the patient. Also, exercise of the tongue muscle must be considered.

  3. Postura de cabeça nas deformidades dentofaciais classe II e classe III Head posture in the presence of class II and class III dentofacial deformities

    Directory of Open Access Journals (Sweden)

    Marcela Ralin de Carvalho Deda

    2012-04-01

    Full Text Available OBJETIVO: este estudo investiga se existe diferença entre grupos com diferentes deformidades dentofaciais (padrão classe II e classe III e o grupo sem a deformidade em relação à postura de cabeça. MÉTODO: participaram deste estudo, voluntariamente, 25 pacientes (entre 16 e 40 anos. Dez pacientes com diagnóstico de deformidade dentofacial classe II e 15 pacientes com o diagnóstico de classe III esquelética e 15 voluntários sadios, com equivalência em sexo e idade ao grupo de deformidade, formando o grupo controle. Primeiramente foi realizada a inspeção da postura de cabeça. Logo em seguida foi realizada a avaliação postural de cabeça por meio da fotografia postural (fotogrametria. RESULTADOS: não houve diferença significante (p>0,05 entre os grupos em relação à avaliação postural utilizando-se a fotogrametria. Já em relação à avaliação postural pela inspeção clínica, observou-se uma postura anterior de cabeça nos indivíduos com a deformidade dentofacial padrão classe II, comparados ao padrão classe III (p = 0,001 e ao grupo controle (p = 0,001. Foi visto também que o grupo deformidade classe II apresentou um percentual inferior de indivíduos com posição neutra de cabeça comparado ao grupo deformidade classe III (p = 0,008 e ao grupo controle (p = 0,001. CONCLUSÃO: indivíduos com deformidade dentofacial classe II podem apresentar uma anteriorização de cabeça. Não há influência da deformidade no aumento ou na redução do ângulo cabeça-pescoço, analisado por meio da fotogrametria.PURPOSE: this study investigates whether there is a difference in head posture between groups with different dentofacial deformities (class II and class III and a group with no deformity. METHOD: 25 volunteers aged from 16 to 40 year old took part in the study. Ten patients had a diagnosis of class II dentofacial deformity, 15 had a diagnosis of class III skeletal deformity, and 15 healthy volunteers matched for sex and

  4. Cone-beam computed tomography based evaluation of rotational patterns of dentofacial structures in skeletal Class III deformity with mandibular asymmetry

    OpenAIRE

    Ryu, Hyeong-Seok; An, Ki-Yong; Kang, Kyung-Hwa

    2015-01-01

    Objective The purpose of this study was to assess rotational patterns of dentofacial structures according to different vertical skeletal patterns by cone-beam computed tomography (CBCT) and analyze their influence on menton deviation in skeletal Class III deformity with mandibular asymmetry. Methods The control group consisted of 30 young adults (15 men, 15 women) without any severe skeletal deformity. The asymmetry group included 55 adults (28 men, 27 women) with skeletal Class III deformity...

  5. Orthopedic coordination of dentofacial development in skeletal Class II malocclusion in conjunction with edgewise therapy. Part I.

    Science.gov (United States)

    Bass, N M

    1983-11-01

    The skeletal Class II malocclusion may be considered to develop as a failure of the coordinating process to maintain harmonious relationships within the developing dentofacial apparatus. If the skeletal elements are too far apart for adaptation to occur and/or if there are functional abnormalities of the orofacial musculature which inhibit coordination from taking place, a malocclusion will result. An orthopedic technique and appliance system has been developed with the intention of improving those factors responsible for the development and perpetuation of the skeletal Class II malocclusion in a primary stage of treatment. This is accomplished by means of restraint and redirection of forward maxillary growth and an increase in the velocity of mandibular growth. Concurrently, adverse soft-tissue influences are eliminated or ameliorated. Edgewise appliance therapy is subsequently carried out for the final correction. The subject is considered in two articles. This first article describes the effects of the restraint of maxillary growth on craniofacial development and the dental changes produced by a maxillary removable splint with extraoral traction and shows how they can be used clinically for correction of the skeletal Class II malocclusion. The experimental and clinical evidence supporting this approach is considered, and case histories show the clinical use of the maxillary splint. This form of maxillary therapy for the skeletal Class II malocclusion has limitations, and it is desirable for it to be incorporated into a comprehensive orthopedic system.

  6. Class III treatment using facial mask: Stability after 10 years

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    Adilson Luiz Ramos

    2014-10-01

    Full Text Available Early Class III malocclusion treatment may not have long-term stability due to mandibular growth. Although some features of this malocclusion point to a better prognosis, it is practically impossible for the orthodontist to foresee cases that require new intervention. Many patients need retreatment, whether compensatory or orthodontic-surgical. The present study reports the case of a Class III patient treated at the end of the mixed dentition with the use of a face mask followed by conventional fixed appliances. The case remains stable 10 years after treatment completion. It was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO as a requirement for the title of certified by the BBO.

  7. Orthodontic retreatment of a Class III patient with significant midline asymmetry and bilateral posterior crossbite.

    Science.gov (United States)

    Brunetto, Ademir R

    2015-01-01

    Posterior crossbite might cause serious long-term functional problems if not early treated. Nevertheless, in older patients, treatment might include palatal expansion in order to correct such malocclusion. In view of the above, this article aims at reporting late correction of bilateral posterior crossbite associated with Angle Class III malocclusion, right subdivision, with consequent midline shift (good skeletal pattern). The case was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO), with DI equal to or greater than 10, as a requirement for the title of certified by the BBO. PMID:25741833

  8. Orthodontic retreatment of a Class III patient with significant midline asymmetry and bilateral posterior crossbite

    Directory of Open Access Journals (Sweden)

    Ademir R. Brunetto

    2015-02-01

    Full Text Available Posterior crossbite might cause serious long-term functional problems if not early treated. Nevertheless, in older patients, treatment might include palatal expansion in order to correct such malocclusion. In view of the above, this article aims at reporting late correction of bilateral posterior crossbite associated with Angle Class III malocclusion, right subdivision, with consequent midline shift (good skeletal pattern. The case was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO, with DI equal to or greater than 10, as a requirement for the title of certified by the BBO.

  9. Orthodontic retreatment using anchorage with miniplate to camouflage a Class III skeletal pattern.

    Science.gov (United States)

    Farret, Marcel Marchiori

    2016-06-01

    This manuscript describes the treatment of a 27-year-old patient who was previously treated with two maxillary first premolar extractions. The patient had skeletal Class III malocclusion, Class III canine relationship, anterior crossbite, and a concave profile. As the patient refused orthognathic surgery, a miniplate was used on the right side of the lower arch as an anchorage unit after the extraction of mandibular first premolars, aiding the retraction of anterior teeth. At the end of treatment, anterior crossbite was corrected, in which first molars and canines were in a Class I relationship, and an excellent intercuspation was reached. Furthermore, patient's profile remarkably improved as a result of mandibular incisor retraction. A 30-month follow-up showed good stability of the results obtained. This case was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO) as one of the requirements to become diplomate by the BBO. PMID:27409659

  10. Early cephalometric characteristics in Class III malocclusion

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    Vanessa Costa Farias

    2012-04-01

    Full Text Available OBJECTIVE: Early identification of craniofacial morphological characteristics allows orthopedic segmented interventions to attenuate dentoskeletal discrepancies, which may be partially disguised by natural dental compensation. To investigate the morphological characteristics of Brazilian children with Class III malocclusion, in stages I and II of cervical vertebrae maturation and compare them with the characteristics of Class I control patients. METHODS: Pre-orthodontic treatment records of 20 patients with Class III malocclusion and 20 control Class I patients, matched by the same skeletal maturity index and sex, were selected. The craniofacial structures and their relationships were divided into different categories for analysis. Angular and linear measures were adopted from the analyses previously described by Downs, Jarabak, Jacobson and McNamara. The differences found between the groups of Class III patients and Class I control group, both subdivided according to the stage of cervical vertebrae maturation (I or II, were assessed by analysis of variance (ANOVA, complemented by Bonferroni's multiple mean comparisons test. RESULTS: The analysis of variance showed statistically significant differences in the different studied groups, between the mean values found for some angular (SNA, SNB, ANB and linear variables (Co - Gn, N - Perp Pog, Go - Me, Wits, S - Go, Ar - Go. CONCLUSION: Assessed children displaying Class III malocclusion show normal anterior base of skull and maxilla, and anterior positioning of the mandible partially related to increased posterior facial height with consequent mandibular counterclockwise rotation.

  11. Evolution of Class III treatment in orthodontics.

    Science.gov (United States)

    Ngan, Peter; Moon, Won

    2015-07-01

    Angle, Tweed, and Moyers classified Class III malocclusions into 3 types: pseudo, dentoalveolar, and skeletal. Clinicians have been trying to identify the best timing to intercept a Class III malocclusion that develops as early as the deciduous dentition. With microimplants as skeletal anchorage, orthopedic growth modification became more effective, and it also increased the scope of camouflage orthodontic treatment for patients who were not eligible for orthognathic surgery. However, orthodontic treatment combined with orthognathic surgery remains the only option for patients with a severe skeletal Class III malocclusion or a craniofacial anomaly. Distraction osteogenesis can now be performed intraorally at an earlier age. The surgery-first approach can minimize the length of time that the malocclusion needs to worsen before orthognathic surgery. Finally, the use of computed tomography scans for 3-dimensional diagnosis and treatment planning together with advances in imaging technology can improve the accuracy of surgical movements and the esthetic outcomes for these patients.

  12. 46 CFR 50.30-20 - Class III pressure vessels.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Class III pressure vessels. 50.30-20 Section 50.30-20... Fabrication Inspection § 50.30-20 Class III pressure vessels. (a) Class III pressure vessels shall be subject... specifically exempted by other regulations in this subchapter. (b) For Class III welded pressure vessels,...

  13. 25 CFR 502.4 - Class III gaming.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Class III gaming. 502.4 Section 502.4 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS DEFINITIONS OF THIS CHAPTER § 502.4 Class III gaming. Class III gaming means all forms of gaming that are not class I gaming or...

  14. 25 CFR 522.12 - Revocation of class III gaming.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Revocation of class III gaming. 522.12 Section 522.12 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR APPROVAL OF CLASS II AND CLASS III ORDINANCES AND RESOLUTIONS SUBMISSION OF GAMING ORDINANCE OR RESOLUTION § 522.12 Revocation of class...

  15. ORTHOGNATIC SURGICAL TREATMENT OF SKELETAL CLASS III MALOCLUSION: CASE REPORT

    OpenAIRE

    GÜNGÖR, AHMET YALÇIN; Turkkahraman, Hakan; Baykul, Timucin; Aydın, Asım

    2012-01-01

    In this case report a case is presented with skeletal class III malocclusion which were treated with proper planned orthognatic surgery and orthodontic treatment. Our patient was a girl with 16 years, 3 months of chronologic and Ru period of skeletal age. A concave soft tissue profile and Class III molar relation was detected in extraoral and intraoral examination. Cephalometric evaluation revealed a significant Class III skeletal discrepancy (ANBº= -6). Presurgical orthodontics involved deco...

  16. Frontal soft tissue analysis using a 3 dimensional camera following two-jaw rotational orthognathic surgery in skeletal class III patients.

    Science.gov (United States)

    Choi, Jong Woo; Lee, Jang Yeol; Oh, Tae-Suk; Kwon, Soon Man; Yang, Sung Joon; Koh, Kyung Suk

    2014-04-01

    Although two dimensional cephalometry is the standard method for analyzing the results of orthognathic surgery, it has potential limits in frontal soft tissue analysis. We have utilized a 3 dimensional camera to examine changes in soft tissue landmarks in patients with skeletal class III dentofacial deformity who underwent two-jaw rotational setback surgery. We assessed 25 consecutive Asian patients (mean age, 22 years; range, 17-32 years) with skeletal class III dentofacial deformities who underwent two-jaw rotational surgery without maxillary advancement. Using a 3D camera, we analyzed changes in facial proportions, including vertical and horizontal dimensions, facial surface areas, nose profile, lip contour, and soft tissue cheek convexity, as well as landmarks related to facial symmetry. The average mandibular setback was 10.7 mm (range: 5-17 mm). The average SNA changed from 77.4° to 77.8°, the average SNB from 89.2° to 81.1°, and the average occlusal plane from 8.7° to 11.4°. The mid third vertical dimension changed from 58.8 mm to 57.8 mm (p = 0.059), and the lower third vertical dimension changed from 70.4 mm to 68.2 mm (p = 0.0006). The average bigonial width decreased from 113.5 mm to 109.2 mm (p = 0.0028), the alar width increased from 34.7 mm to 36.1 mm (p-value = 0.0002), and lip length was unchanged. Mean mid and lower facial surface areas decreased significantly, from 171.8 cm(2) to 166.2 cm(2) (p = 0.026) and from 71.23 cm(2) to 61.9 cm(2) (p orthognathic surgery, and enabled quantitative analysis of changes in frontal soft tissue landmarks and facial proportions that were not possible with conventional 2D cephalometric analysis.

  17. Orthodontics-surgical combination therapy for Class III skeletal malocclusion

    OpenAIRE

    Ravi, M. S.; Nillan K Shetty; Prasad, Rajendra B.

    2012-01-01

    The correction of skeletal Class III malocclusion with severe mandibular prognathism in an adult individual requires surgical and Othodontic combination therapy. The inter disciplinary approach is the treatment of choice in most of the skeletal malocclusions. A case report of an adult individual with Class III malocclusion, having mandibular excess in sagittal and vertical plane and treated with orthodontics,, bilateral sagittal split osteotomy and Le - Forte I osteotomy for the correction of...

  18. A benefit-risk assessment of class III antiarrhythmic agents

    DEFF Research Database (Denmark)

    Elming, Hanne; Brendorp, Bente; Pehrson, Steen;

    2004-01-01

    relief. Since many patients experience a decrease in physical performance as well as a diminished quality of life during arrhythmia there is still a need for antiarrhythmic drug therapy. The development of new antiarrhythmic agents has changed the focus from class I to class III agents since it became...... evident that with class I drug therapy the prevalence of mortality is considerably higher. This review focuses on the benefits and risks of known and newer class III antiarrhythmic agents. The benefits discussed include the ability to maintain sinus rhythm in persistent atrial fibrillation patients, and...... reducing the need for implantable cardioverter defibrillator shock/antitachycardia therapy, since no class III antiarrhythmic agents have proven survival benefit. The risks discussed mainly focus on pro-arrhythmia as torsade de pointes ventricular tachycardia....

  19. Dentofacial injuries in contact sports in Yaounde, Cameroon

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    M A Agbor

    2012-01-01

    Full Text Available Background: Dentofacial injuries constitute serious problems among competitive and recreational athletes, worldwide. Objective: To determine the prevalence of dentofacial injuries and related factors among individuals participating in contact sports in Yaoundé, Cameroon. Materials and Methods: This cross-sectional study among individuals participating in karate, judo, basketball, handball, football and wrestling in Yaoundé, Cameroon was conducted between January and April, 2012. Results: Of the 240 athletes interviewed, 115 and 89 of them reported bodily and dentofacial injuries giving 47.9% and 37.1% prevalence, respectively. The bodily injuries were limbs-(60.0%, chest-(23.5%, abdomen-(11.3% and neck- (5.2%. Mouth and face accounted for 52.8% and 37.1% of the dentofacial injuries, respectively. Other dentofacial injuries were teeth-(6.7% and mandible-(3.4%. Older athletes and years of participation were more likely to experience dentofacial injuries. Karate was the most common cause of dentofacial injuries followed by wrestling. The prevalence of the dentofacial injuries was similar among both genders and was equally prevalent during training and competition. The personal protective equipment use reduced the likelihood of dentofacial injuries among the athletes. Conclusion: The prevalence of dentofacial injuries were high while the personal protective equipment use was low among the individuals participating in contact sports in Yaoundé, Cameroon.

  20. Conservative treatment of Angle Class III malocclusion with anterior crossbite

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    João Hélder Ferreira de Aguiar

    2015-08-01

    Full Text Available Angle Class III malocclusion is characterized by anteroposterior dental discrepancy which might be associated or not with skeletal changes. Class III molar relationship is associated with vertical or lingually tipped mandibular incisors and a usually concave profile. These characteristics seriously affect facial esthetics and most frequently are the reason why patients seek orthodontic treatment. This case was presented to the committee of the Brazilian Board of Orthodontics and Facial Orthopedics (BBO as part of the requisites to become a BBO Diplomate.

  1. 25 CFR 291.5 - Where must the proposal requesting Class III gaming procedures be filed?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Where must the proposal requesting Class III gaming... ECONOMIC ENTERPRISES CLASS III GAMING PROCEDURES § 291.5 Where must the proposal requesting Class III gaming procedures be filed? Any proposal requesting Class III gaming procedures must be filed with...

  2. Reassessing Pre-market Regulation of Class III Medical Devices

    OpenAIRE

    Zollinger, Geri

    2003-01-01

    Regulation of medical devices has evolved over the past twenty-five years. Initially, Congress created a regime where the safety and efficacy of all medical devices would be reviewed to varying degrees, depending on the risk posed by the device. Class III devices, the most dangerous class of devices, were to each have a safety and efficacy review. To permit new market entrants on similar grounds as those marketing devices prior to the 1976 Amendments, Congress also created a premarket notific...

  3. Dentofacial Asymmetries: Challenging Diagnosis and Treatment Planning.

    Science.gov (United States)

    Agrawal, Manish; Agrawal, Jiwan Asha; Nanjannawar, Lalita; Fulari, Sangamesh; Kagi, Vishwal

    2015-07-01

    Dentofacial asymmetry is quite common and when sufficiently severe can require surgical orthodontic intervention. Asymmetries can be classified according to the structures involved into skeletal, dental and functional. In diagnosing asymmetries, a thorough clinical examination and radiographic survey are essential to determine the extent of soft tissue, skeletal, dental and functional involvement. Dental asymmetries, as well as a variety of functional deviations, can be managed orthodontically, whereas significant structural facial asymmetries require a comprehensive orthodontic and orthognathic management. With less severe dental, skeletal and soft tissue deviations the advisability of treatment should be carefully considered. The following article also contains a case report highlighting the importance of proper diagnosis in treatment plan for management of dentofacial asymmetry. PMID:26229387

  4. Dentofacial Asymmetries: Challenging Diagnosis and Treatment Planning

    OpenAIRE

    Agrawal, Manish; Agrawal, Jiwan Asha; Nanjannawar, Lalita; Fulari, Sangamesh; Kagi, Vishwal

    2015-01-01

    Dentofacial asymmetry is quite common and when sufficiently severe can require surgical orthodontic intervention. Asymmetries can be classified according to the structures involved into skeletal, dental and functional. In diagnosing asymmetries, a thorough clinical examination and radiographic survey are essential to determine the extent of soft tissue, skeletal, dental and functional involvement. Dental asymmetries, as well as a variety of functional deviations, can be managed orthodonticall...

  5. Orthodontics-surgical combination therapy for Class III skeletal malocclusion

    Directory of Open Access Journals (Sweden)

    M S Ravi

    2012-01-01

    Full Text Available The correction of skeletal Class III malocclusion with severe mandibular prognathism in an adult individual requires surgical and Othodontic combination therapy. The inter disciplinary approach is the treatment of choice in most of the skeletal malocclusions. A case report of an adult individual with Class III malocclusion, having mandibular excess in sagittal and vertical plane and treated with orthodontics,, bilateral sagittal split osteotomy and Le - Forte I osteotomy for the correction of skeletal, dental and soft tissue discrepancies is herewith presented. The surgical-orthodontic combination therapy has resulted in near-normal skeletal, dental and soft tissue relationship, with marked improvement in the facial esthetics in turn, has helped the patient to improve the self-confidence level.

  6. Prevalence of dentofacial abnormalities in children and adolescents with β-thalassaemia major

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    Arun Elangovan

    2013-01-01

    Full Text Available Background: β-thalassaemia major is a hereditary hemolytic anemia and the patients often experience growth retardation, protrusive maxilla, and depressed nasal bride leading to various degrees of malocclusion. Aim: The purpose of this investigation is to find the prevalence of dentofacial abnormalities in β-thalassaemia major patients. Subjects and Methods: Seventy-two patients between 6 and 18 years of age diagnosed with β-thalassaemia major were examined for extraoral abnormalities, malocclusion, oral hygiene, and dental caries. Data obtained were tabulated and statistically analyzed using Chi-square and paired t-test. Results: Thirty-nine (54.2% were males and 33 (45.8% were females. Prominent extraoral abnormalities were found in 41 (56.9% of the individuals. Study population predominantly had class I occlusion (59.7% followed by class II occlusion (23.6% and no class III occlusion. Mean oral hygiene index-simplified score was 2.43 ± 1.24, mean decayed missing filled teeth (DMFT score was 7.10 ± 3.92, and deft was 5.68 ± 3.12. Conclusion: Despite starting regular blood transfusion at an early age, β-thalassaemia major patients showed marked facial abnormalities. When compared with individuals with no systemic disease, oral hygiene status was similar, but the caries experience was higher in β-thalassaemia major patients. Therefore, emphasis to educate these patients in the prevention and control of dental caries and maintenance of good oral hygiene should be considered.

  7. Orthodontic-surgical treatment of the skeletal class III malocclusion: A case report

    OpenAIRE

    Stojanović Ljiljana S.; Mileusnić Ivan; Mileusnić Budimir; Čutović Tatjana

    2013-01-01

    Background. Class III malocclusions are considered to be ones of the most difficult problems to treat. Their causes are multifactorial and include genetic and/or environmental factors. Class III malocclusions are generally classified into 2 categories: skeletal and dental. The diagnosis is important due to the different treatment approaches. Generally a dental class III can be treated with orthodontics alone, while a true skeletal class III requires a combi...

  8. Compensatory canine angulation in angle Class II and III patients

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    Mauro Carlos Agner Busato

    2009-09-01

    Full Text Available The aim of this study was to evaluate the occurence of compensation in mesiodistal axial inclinations of canines in skeletal malocclusions patients. The sample consisted of 25 Angle Class II, division 1 malocclusion (group 1 and 19 Angle Class III malocclusion patients (group 2. After measurement of dental angulations through a method that associates plaster model photography and AutoCad software, comparisons between the groups were performed by T-test for independent samples. Results showed that there was no statistically significant difference (p < 0.05 between groups, when maxillary canine angulations were compared. Regarding the mandibular canines, there was a statistically significant difference in dental angulation, expressed by 3.2° for group 1 and 0.15° for group 2. An upright position tendency for mandibular canines was observed in the Angle Class III sample. This configures a pattern of compensatory coronary positioning, since the angulation of these teeth makes them occupy less space in the dental arch and consequently mandibular incisors can be in a more retracted position in the sagittal plane.

  9. Vertical control in the Class III compensatory treatment

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    Márcio Costa Sobral

    2013-04-01

    Full Text Available INTRODUCTION: Compensatory orthodontic treatment, or simply orthodontic camouflage, consists in an important alternative to orthognathic surgery in the resolution of skeletal discrepancies in adult patients. It is important to point that, to be successfully performed, diagnosis must be detailed, to evaluate, specifically, dental and facial features, as well as the limitations imposed by the magnitude of the discrepancy. The main complaint, patient's treatment expectation, periodontal limits, facial pattern and vertical control are some of the items to be explored in the determination of the viability of a compensatory treatment. Hyperdivergent patients who carry a Class III skeletal discrepancy, associated with a vertical facial pattern, with the presence or tendency to anterior open bite, deserve special attention. In these cases, an efficient strategy of vertical control must be planned and executed. OBJECTIVE: The present article aims at illustrating the evolution of efficient alternatives of vertical control in hiperdivergent patients, from the use, in the recent past, of extra-oral appliances on the lower dental arch (J-hook, until nowadays, with the advent of skeletal anchorage. But for patients with a more balanced facial pattern, the conventional mechanics with Class III intermaxillary elastics, associated to an accentuated curve of Spee in the upper arch and a reverse Curve of Spee in the lower arch, and vertical elastics in the anterior region, continues to be an excellent alternative, if there is extreme collaboration in using the elastics.

  10. Skeletal class III camouflage by mandibular incisor extraction: A case report

    OpenAIRE

    Janardhanan Kumaresan; Tamizharasi Senthil Kumar; Senthil Kumar

    2014-01-01

    Treatment planning in orthodontics plays a key role in determining the successful treatment of any kind of malocclusion. Skeletal class III malocclusions are generally difficult to treat because of the complex nature of the skeletal and dental manifestations they produce. Mild to moderate skeletal class III malocclusions sometimes have an acceptable facial profile where orthodontic camouflage is possible. In this case report, camouflage of a mild skeletal class III is done by the extraction o...

  11. 76 FR 43701 - Renewal of Agency Information Collection for Class III Tribal State Gaming Compact Process...

    Science.gov (United States)

    2011-07-21

    ... Bureau of Indian Affairs Renewal of Agency Information Collection for Class III Tribal State Gaming... the collection of information for the Class III Tribal State Gaming Compact Process. The information... comments on the information collection to Paula L. Hart, Director, Office of Indian Gaming, 1849 C...

  12. 77 FR 48167 - Approved Tribal-State Class III Gaming Compact; Indian Gaming

    Science.gov (United States)

    2012-08-13

    ... Bureau of Indian Affairs Approved Tribal--State Class III Gaming Compact; Indian Gaming AGENCY: Bureau of Indian Affairs, Interior. ACTION: Notice of Approved Tribal--State Class III Gaming Compact. SUMMARY: This notice publishes an approval of the gaming compact between the Eastern Band of Cherokee...

  13. Dental informatics to characterize patients with dentofacial deformities.

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    Seoung Bum Kim

    Full Text Available Relevant statistical modeling and analysis of dental data can improve diagnostic and treatment procedures. The purpose of this study is to demonstrate the use of various data mining algorithms to characterize patients with dentofacial deformities. A total of 72 patients with skeletal malocclusions who had completed orthodontic and orthognathic surgical treatments were examined. Each patient was characterized by 22 measurements related to dentofacial deformities. Clustering analysis and visualization grouped the patients into three different patterns of dentofacial deformities. A feature selection approach based on a false discovery rate was used to identify a subset of 22 measurements important in categorizing these three clusters. Finally, classification was performed to evaluate the quality of the measurements selected by the feature selection approach. The results showed that feature selection improved classification accuracy while simultaneously determining which measurements were relevant.

  14. The Oropharyngeal Airway in Young Adults with Skeletal Class II and Class III Deformities: A 3-D Morphometric Analysis.

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    Yasas Shri Nalaka Jayaratne

    Full Text Available 1 To determine the accuracy and reliability of an automated anthropometric measurement software for the oropharyngeal airway and 2 To compare the anthropometric dimensions of the oropharyngeal airway in skeletal class II and III deformity patients.Cone-beam CT (CBCT scans of 62 patients with skeletal class II or III deformities were used for this study. Volumetric, linear and surface area measurements retroglossal (RG and retropalatal (RP compartments of the oropharyngeal airway was measured with the 3dMDVultus software. Accuracy of automated anthropometric pharyngeal airway measurements was assessed using an airway phantom.The software was found to be reasonably accurate for measuring dimensions of air passages. The total oropharyngeal volume was significantly greater in the skeletal class III deformity group (16.7 ± 9.04 mm3 compared with class II subjects (11.87 ± 4.01 mm3. The average surface area of both the RG and RP compartments were significantly larger in the class III deformity group. The most constricted area in the RG and RP airway was significantly larger in individuals with skeletal class III deformity. The anterior-posterior (AP length of this constriction was significantly greater in skeletal class III individuals in both compartments, whereas the width of the constriction was not significantly different between the two groups in both compartments. The RP compartment was larger but less uniform than the RG compartment in both skeletal deformities.Significant differences were observed in morphological characteristics of the oropharyngeal airway in individuals with skeletal class II and III deformities. This information may be valuable for surgeons in orthognathic treatment planning, especially for mandibular setback surgery that might compromise the oropharyngeal patency.

  15. The influence of dentofacial appearance on the social attractiveness of young adults.

    Science.gov (United States)

    Shaw, W C; Rees, G; Dawe, M; Charles, C R

    1985-01-01

    The purpose of the study was to determine whether the social attractiveness of a young adult would be influenced by his or her dentofacial appearance. Black and white photographs of an attractive male, an unattractive male, an attractive female, and an unattractive female were obtained and modified so that, for each face, five different photographic versions were available. In each version, the face was standardized except that a different dentofacial arrangement was demonstrated. These were normal incisors, prominent incisors, absence of upper left lateral incisor, severely crowded incisors, and unilateral cleft lip. Eight hundred young adults were shown one of the twenty photographs and asked to estimate the represented individual's social characteristics along a number of bipolar scales. Each photograph was viewed by a different group of forty young adults, equally divided as to sex. Their impressions of the depicted individuals' social attractiveness were recorded on visual analogue scales. The experimental procedure was such that the effect and interaction of different levels of facial attractiveness, different dentofacial arrangements, sex of the photographed individual, and sex of the judge could be analyzed. Faces displaying a normal incisor relationship gained the most favorable ratings for eight of the ten characteristics examined, and in four of these differences across the range of dental conditions were statistically significant. These were perceived friendliness, social class, popularity, and intelligence. The prominent incisor condition was rated highest for compliance and honesty, while the condition representing a unilateral cleft consistently attracted low ratings. Background facial attractiveness of either the male or female stimuli was often more assertive than the individual dental condition.(ABSTRACT TRUNCATED AT 250 WORDS)

  16. The influence of dentofacial appearance on the social attractiveness of young adults.

    Science.gov (United States)

    Shaw, W C; Rees, G; Dawe, M; Charles, C R

    1985-01-01

    The purpose of the study was to determine whether the social attractiveness of a young adult would be influenced by his or her dentofacial appearance. Black and white photographs of an attractive male, an unattractive male, an attractive female, and an unattractive female were obtained and modified so that, for each face, five different photographic versions were available. In each version, the face was standardized except that a different dentofacial arrangement was demonstrated. These were normal incisors, prominent incisors, absence of upper left lateral incisor, severely crowded incisors, and unilateral cleft lip. Eight hundred young adults were shown one of the twenty photographs and asked to estimate the represented individual's social characteristics along a number of bipolar scales. Each photograph was viewed by a different group of forty young adults, equally divided as to sex. Their impressions of the depicted individuals' social attractiveness were recorded on visual analogue scales. The experimental procedure was such that the effect and interaction of different levels of facial attractiveness, different dentofacial arrangements, sex of the photographed individual, and sex of the judge could be analyzed. Faces displaying a normal incisor relationship gained the most favorable ratings for eight of the ten characteristics examined, and in four of these differences across the range of dental conditions were statistically significant. These were perceived friendliness, social class, popularity, and intelligence. The prominent incisor condition was rated highest for compliance and honesty, while the condition representing a unilateral cleft consistently attracted low ratings. Background facial attractiveness of either the male or female stimuli was often more assertive than the individual dental condition.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:3855347

  17. Civilization III and Whole-Class Play in High School Social Studies

    Science.gov (United States)

    Lee, John K.; Probert, Jeffrey

    2010-01-01

    This study examined an 11th grade high school class as they played the game Civilization III. Over nine class sessions students played the game in support of other activities related to several predetermined and emergent topics in U. S. history. Gameplay was whole-class oriented and involved students taking turns at the computer controlling…

  18. Skeletal class III camouflage by mandibular incisor extraction: A case report

    Directory of Open Access Journals (Sweden)

    Janardhanan Kumaresan

    2014-01-01

    Full Text Available Treatment planning in orthodontics plays a key role in determining the successful treatment of any kind of malocclusion. Skeletal class III malocclusions are generally difficult to treat because of the complex nature of the skeletal and dental manifestations they produce. Mild to moderate skeletal class III malocclusions sometimes have an acceptable facial profile where orthodontic camouflage is possible. In this case report, camouflage of a mild skeletal class III is done by the extraction of a single mandibular incisor, which helped in maintaining the profile of the patient and also in the correction of crowding in the mandibular anterior region.

  19. Pleiotropic developmental expression of HasPOU-III, a class III POU gene, in the gastropod Haliotis asinina.

    Science.gov (United States)

    O'Brien, Elizabeth K; Degnan, Bernard M

    2002-06-01

    HasPOU-III is expressed in multiple cell types during the first 3 days of development of the gastropod Haliotis asinina. HasPOU-III expression begins in two bilaterally symmetrical sets of cells on the ventral ectodermal surface of the trochophore larva; one set are putative foot mucous cells. After torsion, HasPOU-III transcripts transiently appear in the developing ganglia of the central nervous system. At the end of larval morphogenesis, HasPOU-III expression is initiated in dorsoposterior cells of the visceral mass, in the posterior cells of the statocyst and in the developing radular sac. These expression patterns in Haliotis, a spiralian lophotrochozoan, are similar to POU Class III genes in other bilaterians where expression occurs in secretory cells and the developing nervous system.

  20. Increased expression of class III β-tubulin in castration-resistant human prostate cancer

    OpenAIRE

    Terry, S; Ploussard, G; Allory, Y; Nicolaiew, N; Boissière-Michot, F; Maillé, P; Kheuang, L; Coppolani, E; Ali, A.; Bibeau, F; Culine, S; Buttyan, R.; de la Taille, A; Vacherot, F

    2009-01-01

    Background: Class III β-tubulin (βIII-tubulin) is expressed in tissues of neuronal lineage and also in several human malignancies, including non-small-cell lung carcinoma, breast and ovarian cancer. Overexpression of βIII-tubulin in these tumours is associated with an unfavourable outcome and resistance to taxane-based therapies. At present, βIII-tubulin expression remains largely uncharacterised in prostate cancer. Methods: In this report, we evaluated the expression of βIII-tubulin in 138 d...

  1. 25 CFR 291.3 - When may an Indian tribe ask the Secretary to issue Class III gaming procedures?

    Science.gov (United States)

    2010-04-01

    ... III gaming procedures? 291.3 Section 291.3 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ECONOMIC ENTERPRISES CLASS III GAMING PROCEDURES § 291.3 When may an Indian tribe ask the Secretary to issue Class III gaming procedures? An Indian tribe may ask the Secretary to issue Class...

  2. 25 CFR 291.12 - Who will monitor and enforce tribal compliance with the Class III gaming procedures?

    Science.gov (United States)

    2010-04-01

    ... Class III gaming procedures? 291.12 Section 291.12 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ECONOMIC ENTERPRISES CLASS III GAMING PROCEDURES § 291.12 Who will monitor and enforce tribal compliance with the Class III gaming procedures? The Indian tribe and the State may have an...

  3. Early class III occlusal tendency in children and its selective management

    Directory of Open Access Journals (Sweden)

    Kapur A

    2008-09-01

    Full Text Available Class III malocclusion may develop in children as a result of an inherent growth abnormality, i.e., true class III malocclusion, or as a result of premature occlusal contacts causing forward functional shift of the mandible, which is known as pseudo class III malocclusion. These cases, if not treated at the initial stage of development, interfere with normal growth of the skeletal bases and may result in severe facial deformities. The treatment should be carried out as early as possible with the aim of permitting normal growth. This paper deals with the selection of an appropriate treatment approach from the various current options available for early intervention in children developing class III occlusal tendencies; the different clinical features are depicted in the three case reports.

  4. Treatment in borderline class III malocclusion: orthodontic camouflage (extraction) versus orthognathic surgery

    OpenAIRE

    A-Bakr M Rabie; Wong, Ricky W.K; Min, G.U.

    2008-01-01

    AIMS: To investigate the differences in morphological characteristics of borderline class III patients who had undergone camouflage orthodontic treatment or orthognathic surgery, and to compare the treatment effects between these two modalities. MATERIALS AND METHODS: Cephalograms of 25 patients (13 orthodontic, 12 surgical) with class III malocclusion were analyzed. All had a pretreatment ANB angle greater than -5 masculine. RESULTS: Using discriminant analysis, only Holdaway angle was selec...

  5. Articulación de fones en individuos clase esqueletal I,II y III Speech patterns in skeletal class I, II and III subjects

    Directory of Open Access Journals (Sweden)

    Pía Villanueva

    2009-09-01

    Full Text Available OBJETIVO: determinar los patrones de articulación de fones consonánticos en sujetos de habla española chilena clases I, II y III esqueletal; comparar las diferencias fonéticas que existan entre clases esqueletales. MÉTODOS: se seleccionaron 54 individuos que cumplían con los criterios de inclusión determinados mediante un examen clínico intraoral y a través del análisis de Ricketts, y se conformaron los grupos de estudio de pacientes clases esqueletales I, II y III. Se les realizó un examen fonoarticulatorio estandarizado para determinar los fones modificados y el patrón articulatorio compensatorio realizado. RESULTADOS: se observaron cambios en el punto de articulación de fones consonánticos en las tres clases esqueletales, con diferencias significativas en los grupos de fones anteriores y medios entre pacientes clases I y II, sólo en el grupo de los fones anteriores entre pacientes I y III. Entre pacientes clases II y III no se observaron diferencias significativas. Se reportan modificaciones y compensaciones cualitativamente distintas entre las clases esqueletales. CONCLUSIONES: en relación a pacientes clase I, los pacientes clase II o III, presentan distinto grado de modificación en el punto de articulación de fones consonánticos. Las diferencias observadas se relacionan con los patrones esqueletales propios de cada clase.PURPOSE: to determine the consonant phonemes articulation patterns in Chilean skeletal class I, II and III Spanish speakers and compare their phonetic differences. METHODS: fifty-four skeletal class I, II and III subjects were selected, based on intraoral clinical examination and Ricketts cephalometric analysis, constituting the study groups. A standardized phonoarticulatory test was applied to each patient to determine the modified phonemes and their compensatory patterns. RESULTS: the findings indicate changes in articulation in all three groups. Significant differences were found in anterior and medium

  6. Má oclusão Classe III de Angle com discrepância ântero-posterior acentuada Angle Class III malocclusion with severe anteroposterior disharmony

    Directory of Open Access Journals (Sweden)

    Marcos Alan Vieira Bittencourt

    2009-02-01

    Full Text Available A má oclusão Classe III de Angle é caracterizada por uma discrepância dentária ântero-posterior, que pode ou não estar acompanhada por alterações esqueléticas. Em geral, o aspecto facial fica bastante comprometido, sendo justamente esse fator, na maioria das vezes, que motiva o paciente a procurar pelo tratamento. Este caso foi apresentado à Diretoria do Board Brasileiro de Ortodontia e Ortopedia Facial (BBO, representando a categoria 4, ou seja, uma má oclusão com discrepância ântero-posterior acentuada, Classe III, com ANB menor ou igual a -2º, como parte dos requisitos para a obtenção do título de Diplomado pelo BBO.Angle Class III malocclusion is characterized by an anteroposterior dental discrepancy which may or may not be accompanied by skeletal changes. In general, distressed by a significantly compromised facial aspect, patients tend to seek treatment. This case was presented to the Brazilian Board of Orthodontics and Facial Orthopedics (BBO, as representative of Category 4, i.e., a malocclusion with severe anteroposterior discrepancy, Class III, and ANB Angle equal to or smaller than -2º, as part of the requirements for obtaining the BBO Diploma.

  7. Assessment of technical documentation of Class III medical devices

    NARCIS (Netherlands)

    Roszek B; de Bruijn ACP; Pot JWGA; van Drongelen AW; BMT; vgc

    2010-01-01

    Europese regelgeving vereist dat fabrikanten van medische hulpmiddelen een dossier opstellen waaruit blijkt dat het hulpmiddel veilig en functioneel is. De kwaliteit van dossiers van de hoogste risicoklasse medische hulpmiddelen, klasse III, laat evenwel te wensen over. Dit blijkt uit onderzoek va

  8. Orthodontic-surgical treatment of the skeletal class III malocclusion: A case report

    Directory of Open Access Journals (Sweden)

    Stojanović Ljiljana S.

    2013-01-01

    Full Text Available Background. Class III malocclusions are considered to be ones of the most difficult problems to treat. Their causes are multifactorial and include genetic and/or environmental factors. Class III malocclusions are generally classified into 2 categories: skeletal and dental. The diagnosis is important due to the different treatment approaches. Generally a dental class III can be treated with orthodontics alone, while a true skeletal class III requires a combination of orthodontics and surgery. Case report. We presented a female patient with skeletal Class III malocclusion. The treatment was complete with positive overbite and acceptable occlusion using a combination of fixed orthodontic appliance treatment as well as the surgical operation. The patient was happy with her new appearance and function. Conclusion. Class III discrepancy should be diagnosed and classified according to its etiology and treated with appropriate surgery, including, if necessary, not only mandibular, but also maxillary surgery, in order to achieve a normal facial appearance. In any case, as the field of orthodontics continues to develop technologically and philosophically, we can expect that advances in diagnosis and treatment planning are imminent and inevitable.

  9. A benefit-risk assessment of class III antiarrhythmic agents

    DEFF Research Database (Denmark)

    Brendorp, Bente; Pedersen, Oledyg; Torp-Pedersen, Christian;

    2002-01-01

    With beta-blockers as the exception, increasing doubt is emerging on the value of antiarrhythmic drug therapy following a series of trials that have either shown no mortality benefit or even an excess mortality. Vaughan Williams class I drugs are generally avoided in patients with structural heart...

  10. Influence of children's dentofacial appearance on teacher expectations.

    Science.gov (United States)

    Shaw, W C; Humphreys, S

    1982-12-01

    The purpose of the study was to determine whether the presence of dentofacial anomaly in a child would unfavourably bias a schoolteacher's expectations of the child's scholastic potential, social relationships or personality. Black and white portrait photographs of an attractive boy and girl and an unattractive boy and girl were obtained and modified so that for each face, five different photographic versions were available. In each version, the child's face was standardized except that a different dentofacial arrangement was demonstrated. These were normal incisors, prominent incisors, missing lateral incisor, severely crowded incisors and unilateral cleft lip. Each photograph was attached to a school record card which presented a standardized educational history of an average pupil. The record cards were evaluated by 320 schoolteachers, uninformed as to the true nature of the investigation, and their assessments recorded on a questionnaire. The experimental procedure was such that the effect and interaction of different levels of facial attractiveness, different dentofacial arrangements, sex of photographed child, and sex of teacher could be analysed. The hypothesis, that children's faces with a normal dental appearance or high background facial attractiveness would gain preferential bias in teacher expectations, was not supported. PMID:6961980

  11. Early treatment of Class III malocclusion with a tandem traction bow appliance

    Directory of Open Access Journals (Sweden)

    Sneha Basaveshwar Valgadde

    2016-01-01

    Full Text Available Since Class III malocclusion is progressive in nature, the facial growth of Class III malocclusion worsens with age. Class III malocclusion is associated with a deviation in the sagittal relationship of the maxilla and the mandible, characterized by a deficient maxilla, retrognathic mandible, or a combination of both. The early orthopedic treatment of Class III malocclusions, at the end of primary dentition or the beginning of mixed dentition, prior to growth spurt, allows the accomplishment of successful results, providing facial balance, modifying the maxillofacial growth and development, and in many instances, preventing a future surgical treatment by increasing the stability. Many treatment approaches can be found in the literature regarding orthopedic and orthodontic treatment of Class III malocclusion, including intra- and extra-oral appliances. The major problem with extraoral anchorage has been of patient compliance due to its physical appearance. The case report presents an intraoral modified tandem appliance for maxillary protraction that has been used clinically to achieve successful results without relying much on patient co-operation.

  12. [The craniofacial architecture of class III malocclusion using the Coben analysis].

    Science.gov (United States)

    Vallée-Cussac, V

    1991-01-01

    In this study, longitudinal tracings of dental and skeletal Class III malocclusion group are compared to tracings of COBEN analysis standard values. Cephalometric measurements and surimpositions illustrate the dynamic variations of Class III cranio-facial architecture for two age ranges: 8 years +/- 1 year and 16 years +/- 1 year. The Class III pathology for children 8 years +/- 1 year aged is characterized by alterations of tracings sizes and position with excessive cranio-facial components length and rotation of cranial base into a more vertical position. A growth rate deficiency in length with a variable individual adaptation is showed for cranial structures except the mandibule after growth at the age of 16 years +/- 1 year.

  13. Regulation of MIR165/166 by class II and class III homeodomain leucine zipper proteins establishes leaf polarity

    DEFF Research Database (Denmark)

    Merelo, Paz; Ram, Hathi; Pia Caggiano, Monica;

    2016-01-01

    -ZIP) transcription factors are key mediators in the regulation of adaxial-abaxial patterning. Their expression is restricted adaxially during early development by the abaxially expressed microRNA (MIR)165/166, yet the mechanism that restricts MIR165/166 expression to abaxial leaf tissues remains unknown. Here, we...... show that class III and class II HD-ZIP proteins act together to repress MIR165/166 via a conserved cis-element in their promoters. Organ morphology and tissue patterning in plants, therefore, depend on a bidirectional repressive circuit involving a set of miRNAs and its targets....

  14. Management of skeletal Class III malocclusion with face mask therapy and comprehensive orthodontic treatment

    Directory of Open Access Journals (Sweden)

    Kirthika Muthukumar

    2016-01-01

    Full Text Available Orthopedic correction of skeletal Class III malocclusion in a growing patient is crucial as it can circumvent future surgical procedures. Further, as surgery is done only at a later stage, early treatment helps to avoid the detrimental effects produced by the facial disfigurement on the patient's social life. This case report describes the treatment of a child aged 9 years 6 months who had a skeletal Class III malocclusion. The treatment plan involved the use of a reverse pull headgear (facemask and multibracket appliance therapy resulting in successful correction of the malocclusion. The treatment results were highly satisfactory resulting in improved facial esthetics, a skeletal Class I with a Dental Class I molar and canine relationship, an ideal overjet and overbite. Thus, dentoalveolar camouflage, if done in properly selected cases, alleviates the need for surgical intervention. The patient is being monitored until the end of growth to ensure the stability of treatment results.

  15. Comparative evaluation of slot versus dovetail design in class III composite restorations in primary anterior teeth

    Directory of Open Access Journals (Sweden)

    Arun Rathnam

    2010-01-01

    It was concluded from the results that the both slot and dovetail types of cavity preparations were equally effacious when clinically reviewed for a period of 12 months. Hence the use of slot type of cavity preparation with reduced loss of the tooth structure is indicated for class III cavities in primary anterior teeth.

  16. Inheritance of craniofacial features in Colombian families with class III malocclusion

    Directory of Open Access Journals (Sweden)

    L Otero

    2010-02-01

    Full Text Available L Otero, L Quintero, D Champsaur, E SimancaPontificia Universidad Javeriana, Bogotá, ColombiaIntroduction: The inheritance of class III malocclusion has been well documented, but the inheritance of craniofacial structures in Colombian families with this malocclusion has been not yet reported.Patients and methods: The study sample of 25 families comprised 186 untreated orthodontic individuals from 8 to 60 years old. Pedigrees were drawn using Cyrillic software. Complete family histories for each proband were ascertained and the affection status of relatives was confirmed by lateral cephalograms and facial and dental photographs. Analysis of variance and odds ratio test for each parameter was performed to estimate inheritance from parents to offspring and to determine similar phenotypic features in relatives.Results: The analysis of the pedigrees suggests autosomal dominant inheritance. The craniofacial characteristics that showed more resemblance between parents and offspring were middle facial height, shorter anterior cranial base and mandibular prognathism. In contrast the protrusion of upper lip and maxillary retrusion were the phenotypic features that contributed to class III in the majority of families.Conclusion: Knowledge of the inheritance of craniofacial phenotypes in class III malocclusion will enable the design of new therapies to treat this malocclusion.Keywords: inheritance, craniofacial, phenotype, class III malocclusion

  17. Lanthanide(III) Complexes of DOTA-Glycoconjugates: A Potential New Class of Lectin-Mediated Medical Imaging Agents

    OpenAIRE

    André, João P.; Geraldes, Carlos F. G. C.; Martins, José A.; Merbach, André E.; Prata, Maria I. M.; Santos, Ana C; Lima, João J. P. de; Tóth, Éva

    2004-01-01

    The synthesis and characterization of a new class of DOTA (1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane) monoamide-linked glycoconjugates (glucose, lactose and galactose) of different valencies (mono, di and tetra) and their Sm(III), Eu(III) and Gd(III) complexes are reported. The proton NMR spectrum of Eu(III)-DOTALac(III) shows the predominance of a single structural isomer of square antiprismatic geometry of the DOTA chelating moiety and fast ...

  18. Má oclusão de Classe I de Angle, com tendência à classe III esquelética, tratada com controle de crescimento Angle Class I malocclusion, with class III skeletal tendency, treated with growth control

    OpenAIRE

    Ademir Roberto Brunetto

    2009-01-01

    A má oclusão de Classe III de Angle é caracterizada por uma relação dentária anteroposterior inadequada, que pode ou não estar acompanhada de alterações esqueléticas. Em geral, o aspecto facial fica bastante comprometido, principalmente quando associada à deficiência no terço médio da face, sendo esse, na maioria das vezes, o principal fator que motiva o paciente a procurar tratamento. Este caso foi apresentado à Diretoria do Board Brasileiro de Ortodontia e Ortopedia Facial (BBO), representa...

  19. Orthodontic camouflage of skeletal Class III malocclusion with miniplate: a case report

    Science.gov (United States)

    Farret, Marcel Marchiori; Farret, Milton M. Benitez; Farret, Alessandro Marchiori

    2016-01-01

    ABSTRACT Introduction: Skeletal Class III malocclusion is often referred for orthodontic treatment combined with orthognathic surgery. However, with the aid of miniplates, some moderate discrepancies become feasible to be treated without surgery. Objective: To report the case of a 24-year-old man with severe skeletal Angle Class III malocclusion with anterior crossbite and a consequent concave facial profile. Methods: The patient refused to undergo orthognathic surgery; therefore, orthodontic camouflage treatment with the aid of miniplates placed on the mandibular arch was proposed. Results: After 18 months of treatment, a Class I molar and canine relationship was achieved, while anterior crossbite was corrected by retraction of mandibular teeth. The consequent decrease in lower lip fullness and increased exposure of maxillary incisors at smiling resulted in a remarkable improvement of patient's facial profile, in addition to an esthetically pleasing smile, respectively. One year later, follow-up revealed good stability of results. PMID:27653269

  20. Data on HLA class I/II profile in Brazilian pemphigus patients.

    Science.gov (United States)

    Franco Brochado, Maria José; Nascimento, Daniela Francisca; Saloum Deghaide, Neifi Hassan; Donadi, Eduardo Antonio; Roselino, Ana Maria

    2016-09-01

    Pemphigus are blistering autoimmune diseases related with genetic and environmental factors. Here we describe HLA genotyping in pemphigus patients. First, we review the HLA class I/II data on pemphigus reported in Brazilian samples and then present the HLA class I (-A, -B, -C) and class II (-DRB1, -DQA1, -DQB1) alleles related to susceptibility/resistance to pemphigus by comparing 86 patients with pemphigus foliaceus, 83 patients with pemphigus vulgaris, and 1592 controls from the northeastern region of the state of São Paulo, Southeastern Brazil. The data presented here are related to the manuscript "Differential HLA class I and class II associations in Pemphigus Foliaceus and Pemphigus Vulgaris patients from a prevalent Southeastern Brazilian region" Brochado et al. (2016) [1]. PMID:27331116

  1. 76 FR 71600 - Renewal of Agency Information Collection for Class III Tribal-State Gaming Compact Process...

    Science.gov (United States)

    2011-11-18

    ... Bureau of Indian Affairs Renewal of Agency Information Collection for Class III Tribal- State Gaming... collection of information for the Class III Tribal State Gaming Compact Process. The information collection....eop.gov . Please send a copy of your comments to Paula L. Hart, Director, Office of Indian...

  2. Má oclusão de Classe I de Angle, com tendência à classe III esquelética, tratada com controle de crescimento Angle Class I malocclusion, with class III skeletal tendency, treated with growth control

    Directory of Open Access Journals (Sweden)

    Ademir Roberto Brunetto

    2009-10-01

    Full Text Available A má oclusão de Classe III de Angle é caracterizada por uma relação dentária anteroposterior inadequada, que pode ou não estar acompanhada de alterações esqueléticas. Em geral, o aspecto facial fica bastante comprometido, principalmente quando associada à deficiência no terço médio da face, sendo esse, na maioria das vezes, o principal fator que motiva o paciente a procurar tratamento. Este caso foi apresentado à Diretoria do Board Brasileiro de Ortodontia e Ortopedia Facial (BBO, representando a categoria livre, como parte dos requisitos para a obtenção do título de Diplomado pelo BBO.Angle Class III malocclusion is characterized by an anteroposterior dental alteration, which might be accompanied by skeletal deformities. Usually, the facial aspect becomes aesthetically compromised, mostly when the middle third of the face is affected (this is the main reason why patients seek for treatment.This case was presented to the directorship of the Brazilian Board of Orthodontics and Facial Orthopedics (BBO, standing for the free category, as a part of the requirements to obtain the Board's Certificate.

  3. Gap junctions enhancer combined with Vaughan Williams class III antiarrhythmic drugs, a promising antiarrhythmic method?

    Science.gov (United States)

    Li, Lian-dong; Zhang, Cun-tai; Ruan, Lei; Ni, Ming-ke; Quan, Xiao-qing

    2011-01-01

    Arrhythmias is one of the leading causes of death in the world. Current antiarrhythmic drugs are limited by unsatisfactory efficacy and adverse effects such as proarrhythmias. Reentry mechanism plays an important role in persistence of arrhythmias. Reentry can only continue when reentry path-length is longer than cardiac wavelength which is equal to the product of conduction velocity (CV) and effective refractory period (ERP). Gap junctions uncoupling is associated with proarrhythmic CV slowing and transmural dispersion of repolarization (TDR) increasing in many cardiac diseases. Vaughan Williams class III antiarrhythmic drugs prolong ERP with an augmented TDR which is the main mechanism of the proarrhythmic effects. Gap junctions enhancer can augment CV and diminish TDR. As a result, gap junctions enhancer combined with class III drugs may be a promising antiarrhythmic method.

  4. Combined orthognathic surgery and prosthetic treatment for class III skeletal malocclusion

    Directory of Open Access Journals (Sweden)

    Luka Dias Wellar

    2013-01-01

    Full Text Available This clinical report discusses the case of a partially edentulous patient with class III skeletal malocclusion, suffering from poor masticatory function and esthetic appearance caused by severe anteroposterior discrepancy between the dental arches and loss of occlusal vertical dimension. The functional and esthetic rehabilitation was performed with orthognathic surgery followed by prosthetic treatment using an overlay removable partial denture. At the end of the treatment, the patient was successfully rehabilitated, both functionally and esthetically, through reestablishment of the occlusal vertical dimension and correction of the anteroposterior discrepancy between the dental arches. The overlay removable partial denture is a simple and time-efficient alternative in the treatment of partially edentulous patients with class III skeletal malocclusions and small anteroposterior discrepancies between dental arches. Additionally, an esthetic smile and functional rehabilitation of the stomatognathic system was satisfactorily obtained with orthognathic surgery followed by prosthetic treatment.

  5. Compensatory treatment of Angle Class III malocclusion with anterior open bite and mandibular asymmetry

    Directory of Open Access Journals (Sweden)

    Marcio Costa Sobral

    2012-06-01

    Full Text Available Class III malocclusion is characterized by anterior posterior dental disharmony, either with or without skeletal discrepancies. Facial esthetics may be compromised to a greater or lesser degree, depending on the magnitude of the discrepancy, and is one of the main factors motivating individuals to seek orthodontic treatment. In adult patients, therapy may be performed by means of dental compensation, in simpler cases, or in more severe situations, by means of association between Orthodontics and Orthognathic Surgery. The present article is a clinical case report of a patient with a vertical facial pattern, Angle Class III malocclusion, with open bite and important facial asymmetry. The patient was treated in a compensatory manner with extractions, using extra-oral appliances on the mandibular arch with high pull, applying the principles of the Tweed-Merrifield technique. This case was presented to the Brazilian Board of Orthodontics and Facial Orthopedics (BBO as part of the requisites for becoming a BBO Diplomate.

  6. C-orthodontic microimplant for distalization of mandibular dentition in Class III correction.

    Science.gov (United States)

    Chung, Kyurhim; Kim, Seong-Hun; Kook, Yoonah

    2005-01-01

    A 16-year-old male patient with a Class III malocclusion and 2 lower missing central incisors presented for treatment. The treatment plan consisted of asymmetrically distalizing the lower dentition and regaining space for lower anterior prosthetic work. C-implants were to be used as anchorage for Class III intermaxillary elastics, and two C-orthodontic microimplants (C-implants) were placed in the interdental spaces between the upper second premolars and first molars. The particular design of the C-implant head minimized gingival irritation during the orthodontic treatment. Sliding jigs were applied on the buccal for distalization of the lower posterior teeth. The correct overbite and overjet were obtained by distalizing the entire lower dentition into its proper position with C-implant anchorage, which contributed to an improvement in facial balance. It took 15 months to treat this case. The application of this new microimplant, considerations for case selection, and the sequence of treatment are presented.

  7. Correction of class III malocclusion using modified tandem appliance-two case reports

    Directory of Open Access Journals (Sweden)

    J Jeevarathan

    2013-01-01

    Full Text Available Skeletal discrepancies in growing children can have great physical and psychological impact on their appearance. These deformities require orthopedic correction at an appropriate age to avoid future extensive management. Managing a midfacial deficiency or true mandibular prognathism is perhaps the most challenging situation for the clinician. Many orthopedic appliances like chin cup, facemask, and so on have been advocated to correct class III malocclusion. The major problems with these appliances are physical appearance, skin irritation from the anchorage pads and hence, less patient compliance. We present management of class III malocclusion in two children with modified tandem appliance (MTA, which is an intraoral appliance, with no extraoral anchorage, and has better patient compliance and cooperation.

  8. Correction of class III malocclusion using modified tandem appliance-two case reports.

    Science.gov (United States)

    Jeevarathan, J; Koora, Kiran; Sudhakar, V; Muthu, M S; Prabhu, Rathna V

    2013-01-01

    Skeletal discrepancies in growing children can have great physical and psychological impact on their appearance. These deformities require orthopedic correction at an appropriate age to avoid future extensive management. Managing a midfacial deficiency or true mandibular prognathism is perhaps the most challenging situation for the clinician. Many orthopedic appliances like chin cup, facemask, and so on have been advocated to correct class III malocclusion. The major problems with these appliances are physical appearance, skin irritation from the anchorage pads and hence, less patient compliance. We present management of class III malocclusion in two children with modified tandem appliance (MTA), which is an intraoral appliance, with no extraoral anchorage, and has better patient compliance and cooperation.

  9. THERAPEUTIC DIFFICULTIES IN ACHIEVEMENT OF OPTIMAL ROOT COVERAGE AND AESTHETIC IN CLASS III GINGIVAL RECESSION.

    Directory of Open Access Journals (Sweden)

    Christina Popova

    2013-07-01

    Full Text Available The width of the attached gingiva is defined as a distance between the depth of the gingival sulcus or gingival/periodontal pocket to the mucogingival junction. Authors suggest that a minimal amount of attached gingiva is necessary to ensure the gingival health. When the buccal bone plate and gingival tissues are thin and the position of the tooth is too vestibular gingival margin often displaces apically, and gingival recession develops. In the presence of gingival recession and reduced vestibular depth oral hygiene procedures are embarrassed.The definition of class III gingival recession is marginal lack of tissue extended to/or beyond the mucogingival junction with bone and soft tissue loss interdentally or malpositioning of the tooth.Prognosis for class III and IV gingival recession is that only partial coverage can be expected after root coverage procedures - FGG (free gingival graft or connective tissue graft (CTG. Adjunctive surgical techniques would be helpful to achieve better aesthetic outcomes.

  10. Compensatory treatment of Angle Class III malocclusion with anterior open bite and mandibular asymmetry

    OpenAIRE

    Marcio Costa Sobral

    2012-01-01

    Class III malocclusion is characterized by anterior posterior dental disharmony, either with or without skeletal discrepancies. Facial esthetics may be compromised to a greater or lesser degree, depending on the magnitude of the discrepancy, and is one of the main factors motivating individuals to seek orthodontic treatment. In adult patients, therapy may be performed by means of dental compensation, in simpler cases, or in more severe situations, by means of association between Orthodontics ...

  11. Surgical-orthodontic treatment of Class III malocclusion with agenesis of lateral incisor and unerupted canine

    OpenAIRE

    Bruno Boaventura Vieira; Ana Carolina Meng Sanguino; Marilia Rodrigues Moreira; Elizabeth Norie Morizono; Mírian Aiko Nakane Matsumoto

    2013-01-01

    INTRODUCTION: Orthodontic-surgical treatment was performed in patient with skeletal Class III malocclusion due to exceeding mandibular growth. Patient also presented upper and lower dental protrusion, overjet of -3.0 mm, overbite of -1.0 mm, congenital absence of tooth #22, teeth #13 and supernumerary impaction, tooth #12 with conoid shape and partly erupted in supraversion, prolonged retention of tooth #53, tendency to vertical growth of the face and facial asymmetry. The discrepancy on the ...

  12. Orthodontic retreatment of a Class III patient with significant midline asymmetry and bilateral posterior crossbite

    OpenAIRE

    Brunetto, Ademir R.

    2015-01-01

    Posterior crossbite might cause serious long-term functional problems if not early treated. Nevertheless, in older patients, treatment might include palatal expansion in order to correct such malocclusion. In view of the above, this article aims at reporting late correction of bilateral posterior crossbite associated with Angle Class III malocclusion, right subdivision, with consequent midline shift (good skeletal pattern). The case was presented to the Brazilian Board of Orthodontics and Den...

  13. Modifications of the marginal paradentium to a case of Angle Class III/1 malocclusion.

    Science.gov (United States)

    Dascălu, Ionela Teodora; Tuculină, Mihaela Jana; Răescu, Mihaela; Popescu, Sanda Mihaela; Corega, Claudia; Vaida, Ligia; Bold, Adriana

    2013-01-01

    Angle Class III malocclusions are not so frequently met but they raise big problems of treatment. The analyzed case represents a 14-year-old patient that came to the dental consulting room with an Angle Class III malocclusion determined by the excess of the somatotropic pituitary hormone and a gingival hyperplasia more emphasized at the level of inferior frontal teeth. The patient followed a fixed appliance treatment, the straight-wire technique. All along the treatment and after it, the hyperplasia and the gingival inflammation not only maintained but they even got worse. Thus, an improper hygiene associated with a severe Angle Class III malocclusion maintains and aggravates the gingivitis. The histological and immunohistochemical study of the gingiva revealed important epithelial modifications that led to an epithelial hypertrophy with a tendency toward acanthosis and to severe epithelial erosions. An inflammatory chronic process (rich in lymphocytes, plasma cells and macrophages full of angiogenesis vessels) and an intense reaction of the fibroblastic cells appeared in the gingival corium. PMID:24322040

  14. Free gingival graft in the treatment of class III gingival recession

    Directory of Open Access Journals (Sweden)

    Remya V

    2008-01-01

    Full Text Available Aim: The purpose of this study was to assess the success and predictability of root coverage and esthetics obtained with free gingival grafts (FGGs in the treatment of early class III gingival recessions for a period of 12 months. Materials and Methods: Ten patients contributed to 12 sites, each with early class III recession with interdental bone loss £4 mm from cemento enamel junction(CEJ. Clinical parameters recorded at baseline and at 1, 6, and 12 months were probing depth (PD, recession depth (RD, recession width (RW, and clinical attachment level (CAL. Results: Reduction of recession resulted in a significant gain in CAL and PD at the end of 12 months. A statistically significant mean root coverage of 41.25 ± 21.07% was obtained at the end of 12 months. A statistically significant improvement in Visual Analog Scale score was seen after a 12-month follow-up period. Conclusion: In a south Indian population, early class III gingival recessions treated with FGG procedures resulted in 40-50% root coverage with fairly acceptable esthetics.

  15. Transparent aligners: An invisible approach to correct mild skeletal class III malocclusion.

    Science.gov (United States)

    Yezdani, A Arif

    2015-04-01

    This case report highlights the treatment of a mild skeletal class III malocclusion with an invisible thermoplastic retainer. A 15-year-old female patient presented with a mild skeletal class III malocclusion with a retrognathic maxilla, orthognathic mandible, a low mandibular plane angle with Angle's class III malocclusion with maxillary lateral incisors in anterior cross-bite with crowding of maxillary anteriors, imbricated and rotated mandibular incisors and deep bite. Accurate upper and lower impressions and a bite registration were taken with polyvinyl siloxane rubber base impression material. This was then sent to the lab for the processing of a series of ClearPath aligners. The ClearPath virtual set-up sent from the lab provided the treatment plan and interproximal reduction estimation complete with posttreatment results. This enabled the clinician to actively participate in the treatment plan and provide the necessary suggestions. The ClearPath three-dimensional aligner was found to have effectively corrected the anterior cross-bite and crowding of the maxillary anteriors.

  16. Transparent aligners: An invisible approach to correct mild skeletal class III malocclusion

    Directory of Open Access Journals (Sweden)

    A Arif Yezdani

    2015-01-01

    Full Text Available This case report highlights the treatment of a mild skeletal class III malocclusion with an invisible thermoplastic retainer. A 15-year-old female patient presented with a mild skeletal class III malocclusion with a retrognathic maxilla, orthognathic mandible, a low mandibular plane angle with Angle′s class III malocclusion with maxillary lateral incisors in anterior cross-bite with crowding of maxillary anteriors, imbricated and rotated mandibular incisors and deep bite. Accurate upper and lower impressions and a bite registration were taken with polyvinyl siloxane rubber base impression material. This was then sent to the lab for the processing of a series of ClearPath aligners. The ClearPath virtual set-up sent from the lab provided the treatment plan and interproximal reduction estimation complete with posttreatment results. This enabled the clinician to actively participate in the treatment plan and provide the necessary suggestions. The ClearPath three-dimensional aligner was found to have effectively corrected the anterior cross-bite and crowding of the maxillary anteriors.

  17. Má oclusão Classe III, com mordida cruzada posterior unilateral e assimetria facial Class III malocclusion with unilateral posterior crossbite and facial asymmetry

    OpenAIRE

    Silvio Rosan de Oliveira

    2010-01-01

    Este artigo relata o tratamento ortodôntico realizado em uma paciente adulta, com 36 anos de idade, portadora de um padrão esquelético e dentário de Classe III, com mordida cruzada posterior unilateral esquerda e assimetria mandibular, além de uma diferença relativamente grande entre máxima intercuspidação habitual (MIH) e relação cêntrica (RC). O tratamento foi realizado com expansão dentária superior, contração dentária inferior e descruzamento anterior, eliminando a diferença entre MIH e R...

  18. X-Shooter spectroscopy of young stellar objects III. Photospheric and chromospheric properties of Class III objects

    CERN Document Server

    Stelzer, B; Alcala, J M; Manara, C F; Biazzo, K; Covino, E; Rigliaco, E; Testi, L; Covino, S; D'Elia, V

    2013-01-01

    We analyzed X-Shooter/VLT spectra of 24 ClassIII sources from three nearby star-forming regions (sigmaOrionis, LupusIII, and TWHya). We determined the effective temperature, surface gravity, rotational velocity, and radial velocity by comparing the observed spectra with synthetic BT-Settl model spectra. We investigated in detail the emission lines emerging from the stellar chromospheres and combined these data with archival X-ray data to allow for a comparison between chromospheric and coronal emissions. Both X-ray and Halpha luminosity as measured in terms of the bolometric luminosity are independent of the effective temperature for early-M stars but decline toward the end of the spectral M sequence. For the saturated early-M stars the average emission level is almost one dex higher for X-rays than for Halpha: log(L_x/L_bol) = -2.85 +- 0.36 vs. log(L_Halpha/L_bol) = -3.72 +- 0.21. When all chromospheric emission lines (including the Balmer series up to H11, CaII HK, the CaII infrared triplet, and several HeI...

  19. Nonsurgical treatment of adult open bite using edgewise appliance combined with high-pull headgear and class III elastics.

    Science.gov (United States)

    Saito, Isao; Yamaki, Masaki; Hanada, Kooji

    2005-03-01

    This case report describes the effect of a combination of high-pull headgear and Class III elastics on the nonsurgical treatment of an adult open bite. The 19-year 1-month-old Japanese female presented with the anterior open bite of 4.0 mm and mild crowding. She had a skeletal Class II but a Class III molar relationship due to a severe proclination of the mandibular dental arch. Unilateral congenital missing premolars caused a discrepancy between the facial and dental midline. After extraction of two premolars and the impacted mandibular third molars, nonsurgical therapy was performed using the standard edgewise appliance combined with a high-pull headgear and Class III elastics. The successful treatment outcome and stability of the final occlusion indicates that a combination of high-pull headgear and Class III elastics is one of the effective devices in the nonsurgical treatment of open bite and, is especially helpful in uprighting the mandibular dental arch.

  20. The Position of Hyoici Bone in Skeletal Class I, II and III Patients

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    Ravanmehr H

    2000-06-01

    Full Text Available In this investigation, the position of hyoid bone was compared in three skeletal groups of class I, II and III. The study was based on evaluating 77 lateral cephalometric radiographs, 40 girls and 37 boys, which were divided into 3 groups. Group 1, 2, and 3 consist of 26, 25, and 26 radiographs. 19 cephalometric landmarks and 10 planes were used in order to tracing the radiographs. In all patients, 9 skeletal and 4 cervical vertebrae parameters were measured to determine the hyoid bone. These parameters were compared between three skeletal groups regardless of sex and then, in another statistical analysis, parameters were compared based on patients sex. Statistical analysis showed that in class III patients, the hyoid bone was positioned more anteriorly than two other groups. Also in this group, the hyoid bone had less inclination and it was more horizontal in relation to mandibular plane. In skeletal class II patients this bone was positioned more superiorly than two other groups. Due to these findings it can be concluded that perimandibular muscles and bones could affect the growth of mandible. In addition, comparison of the parameters between two sexes revealed that the hyoid bone was positioned more anteriorly and inferiorly in boys. Also it was shown that in the girls, the position of hyoid bone was closer to the position of this bone in skeletal class I patients.

  1. Auditory characteristics of individuals with temporomandibular dysfunctions and dentofacial deformities

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    Tatiane Totta

    2013-10-01

    Full Text Available OBJECTIVE: To investigate whether there is any relationship between otological as well as vestibular symptoms, audiological findings and type of temporomandibular disorder (articular, muscular and mixed; and to check the distribution of the temporomandibular disorders (TMD dysfunction degree in the research population. METHODS: A retrospective study involving 30 patients of both sexes, aged between 18 and 49 years old, diagnosed with TMD and dentofacial deformities, who were subject to clinical evaluation (muscle palpation, auscultation of temporomandibular joint during mandibular motion and measurement of jaw movement, audiological testing (pure tone audiometry and immittance testing and two questionnaires, one on otological and vestibular symptoms and the other on TMD anamnesis. Based on both the anamnesis questionnaire and the clinical assessment, the subjects were divided according to the type and degree of TMD dysfunction (mild, moderate and severe, and compared regarding the occurrence of auditory signs and symptoms, vestibular symptoms and audiological findings according to TMD type. RESULTS: The anamnesis questionnaire demonstrated higher prevalence (83.33% of severe TMD. Subjects with mixed TMD had more complaints about hypoacusis than those with muscular TMD (p < 0.05. The results showed no change in either audiological and immittance testing for all assessed individuals. CONCLUSION: Otological symptoms are present in subjects with TMD and dentofacial deformities, regardless of the classification of TMD (articular, muscular or mixed. Those with mixed TMD may have higher incidence of complaints about hypoacusis than subjects with muscular TMD. Further studies are needed to investigate the relationship between otological symptoms and the different types of TMD.

  2. Base of the skull morphology and Class III malocclusion in patients with unilateral cleft lip and palate

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    Mariana Maciel Tinano

    2015-02-01

    Full Text Available OBJECTIVE: The aim of the present study was to determine the morphological differences in the base of the skull of individuals with cleft lip and palate and Class III malocclusion in comparison to control groups with Class I and Class III malocclusion. METHODS: A total of 89 individuals (males and females aged between 5 and 27 years old (Class I, n = 32; Class III, n = 29; and Class III individuals with unilateral cleft lip and palate, n = 28 attending PUC-MG Dental Center and Cleft Lip/Palate Care Center of Baleia Hospital and PUC-MG (CENTRARE were selected. Linear and angular measurements of the base of the skull, maxilla and mandible were performed and assessed by a single calibrated examiner by means of cephalometric radiographs. Statistical analysis involved ANCOVA and Bonferroni correction. RESULTS: No significant differences with regard to the base of the skull were found between the control group (Class I and individuals with cleft lip and palate (P > 0.017. The cleft lip/palate group differed from the Class III group only with regard to CI.Sp.Ba (P = 0.015. Individuals with cleft lip and palate had a significantly shorter maxillary length (Co-A in comparison to the control group (P < 0.001. No significant differences were found in the mandible (Co-Gn of the control group and individuals with cleft lip and palate (P = 1.000. CONCLUSION: The present findings suggest that there are no significant differences in the base of the skull of individuals Class I or Class III and individuals with cleft lip and palate and Class III malocclusion.

  3. 40 CFR Figure C-2 to Subpart C of... - Illustration of the Slope and Intercept Limits for Class II and Class III PM2.5 Candidate...

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 5 2010-07-01 2010-07-01 false Illustration of the Slope and Intercept Limits for Class II and Class III PM2.5 Candidate Equivalent Methods C Figure C-2 to Subpart C of Part 53... Methods and Reference Methods Pt. 53, Subpt. C, Fig. C-2 Figure C-2 to Subpart C of Part...

  4. Surgical-orthodontic treatment of Class III malocclusion with agenesis of lateral incisor and unerupted canine

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    Bruno Boaventura Vieira

    2013-06-01

    Full Text Available INTRODUCTION: Orthodontic-surgical treatment was performed in patient with skeletal Class III malocclusion due to exceeding mandibular growth. Patient also presented upper and lower dental protrusion, overjet of -3.0 mm, overbite of -1.0 mm, congenital absence of tooth #22, teeth #13 and supernumerary impaction, tooth #12 with conoid shape and partly erupted in supraversion, prolonged retention of tooth #53, tendency to vertical growth of the face and facial asymmetry. The discrepancy on the upper arch was -2.0 mm and -5.0 mm on the lower arch. METHODS: The pre-surgical orthodontic treatment was performed with extractions of the teeth #35 and #45. On the upper arch, teeth #53, #12 and supernumerary were extracted to accomplish the traction of the impacted canine. The spaces of the lower extractions were closed with mesialization of posterior segment. After aligning and leveling the teeth, extractions spaces closure and correct positioning of teeth on the bone bases, the correct intercuspation of the dental arch, with molars and canines in Angle's Class I, coincident midline, normal overjet and overbite and ideal torques, were evaluated through study models. The patient was submitted to orthognathic surgery and then the post-surgical orthodontic treatment was finished. RESULTS: The Class III malocclusion was treated establishing occlusal and facial normal standards.

  5. Diagnosis and conservative treatment of skeletal Class III malocclusion with anterior crossbite and asymmetric maxillary crowding.

    Science.gov (United States)

    Tseng, Linda L Y; Chang, Chris H; Roberts, W Eugene

    2016-04-01

    A man, aged 28 years 9 months, came for an orthodontic consultation for a skeletal Class III malocclusion (ANB angle, -3°) with a modest asymmetric Class II and Class III molar relationship, complicated by an anterior crossbite, a deepbite, and 12 mm of asymmetric maxillary crowding. Despite the severity of the malocclusion (Discrepancy Index, 37), the patient desired noninvasive camouflage treatment. The 3-Ring diagnosis showed that treatment without extractions or orthognathic surgery was a viable approach. Arch length analysis indicated that differential interproximal enamel reduction could resolve the crowding and midline discrepancy, but a miniscrew in the infrazygomatic crest was needed to retract the right buccal segment. The patient accepted the complex, staged treatment plan with the understanding that it would require about 3.5 years. Fixed appliance treatment with passive self-ligating brackets, early light short elastics, bite turbos, interproximal enamel reduction, and infrazygomatic crest retraction opened the vertical dimension of the occlusion, improved the ANB angle by 2°, and achieved excellent alignment, as evidenced by a Cast Radiograph Evaluation score of 28 and a Pink and White dental esthetic score of 3. PMID:27021460

  6. Má oclusão Classe III, com mordida cruzada posterior unilateral e assimetria facial Class III malocclusion with unilateral posterior crossbite and facial asymmetry

    Directory of Open Access Journals (Sweden)

    Silvio Rosan de Oliveira

    2010-10-01

    Full Text Available Este artigo relata o tratamento ortodôntico realizado em uma paciente adulta, com 36 anos de idade, portadora de um padrão esquelético e dentário de Classe III, com mordida cruzada posterior unilateral esquerda e assimetria mandibular, além de uma diferença relativamente grande entre máxima intercuspidação habitual (MIH e relação cêntrica (RC. O tratamento foi realizado com expansão dentária superior, contração dentária inferior e descruzamento anterior, eliminando a diferença entre MIH e RC. O resultado obtido foi pautado sobre um diagnóstico criterioso e um planejamento de compensação ortodôntica, sem intervenção cirúrgica nos maxilares, por solicitação da paciente. Este caso foi apresentado à Diretoria do Board Brasileiro de Ortodontia e Ortopedia Facial (BBO, representando a categoria 5, ou seja, má oclusão com problema transverso, apresentando pelo menos um quadrante em cruzamento, como parte dos requisitos para obtenção do título de Diplomado pelo BBO.This article reports on the orthodontic treatment performed on a 36-year-old female patient with skeletal and dental Class III pattern, presenting with a left unilateral posterior crossbite and mandibular asymmetry, and a relatively significant difference between maximum intercuspation (MIC and centric relation (CR. The treatment was performed with maxillary dental expansion, mandibular dental contraction and anterior crossbite correction, eliminating the difference between MIC and CR. Results were based on careful diagnosis and planning of orthodontic compensation without surgical intervention in the maxilla, at the request of the patient. This case was presented to the Brazilian Board of Orthodontics and Facial Orthopedics (BBO as representative of Category 5, i.e., malocclusion with a transverse problem, presenting with a crossbite in at least one of the quadrants, as part of the requirements for obtaining the BBO Certificate.

  7. Nonalcoholic Fatty Liver Disease Relationship with Metabolic Syndrome in Class III Obesity Individuals

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    A. Cordeiro

    2015-01-01

    Full Text Available Introduction. Obesity is represented mainly by abdominal obesity and insulin resistance (IR, both present in most individuals diagnosed with metabolic syndrome (MS. IR is the key risk factor in the pathogenesis of nonalcoholic fatty liver disease (NAFLD. Objective. To relate NAFLD to MS in class III obese individuals. Methodology. A descriptive cross-sectional study with class III obese individuals, aged ≥ 20–60 years. Blood pressure measurement, weight, height, body mass index (BMI, waist circumference (WC and blood glucose, insulin, high-density lipoprotein cholesterol (HDL-c, and triglycerides data were obtained. HOMA-IR (homeostatic model assessment insulin resistance calculation was carried out with a cutoff value of 2.71 for IR evaluation. The diagnosis of NAFLD was performed by liver biopsy and the diagnosis of MS was performed in accordance with the National Cholesterol Education Program/Adult Treatment Panel III (NCEPATP III. Results. Of the 50 individuals evaluated, 86% were women and BMI means were 45.4 ± 3.6 Kg/m2. The overall individuals had NAFLD, 70% steatosis, and 30% steatohepatitis. The diagnosis of MS occurred in 56% but showed no significant association with NAFLD (P=0.254. Triglycerides (178 ± 65.5 mg/dL and insulin (28.2 ± 22.6 mcU/mL mean values were significantly higher in steatohepatitis (P=0.002 and P=0.042, resp. compared to individuals with steatosis. IR was confirmed in 76% and showed a relationship with NAFLD severity. Conclusion. NAFLD was not related to MS; however, MS components, evaluated in isolation, as well as IR, were related to the presence and severity of NAFLD.

  8. LONG TERM EFFECTS OF SKELETAL CLASS III TREATMENT: A CASE REPORT

    OpenAIRE

    GÜNGÖR, AHMET YALÇIN; Turkkahraman, Hakan

    2013-01-01

    Even class III treatment in pubertal ages is more difficult than treatment of other maloclusions, its results could be change later especially due to late mandibular growth. This case describes stabile results of a patient, at the last period of her growth and development, from 14 to 19 years old. Our patient was a 14.3 years old girl at Ru period of skeletal maturation. Extraorally, patient had a concave profile, lower midline was symmetric, upper midline was 3mm dislocated to right from ...

  9. Correction of transverse maxillary deficiency and anterior open bite in an adult Class III skeletal patient

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    Prerna Hoogan Teja

    2016-01-01

    Full Text Available Transverse maxillary deficiency may be associated with sagittal or vertical problems of the maxilla or mandible. It may contribute to unilateral or bilateral posterior crossbite, anterior dental crowding, and unesthetic black buccal corridors on smiling. An adequate transverse dimension is important for stable and proper functional occlusion. Surgically, assisted rapid palatal expansion has been the treatment of choice to resolve posterior crossbite in skeletally mature patients. The following case report presents an adult Class III skeletal patient with an anterior open bite and bilateral posterior crossbite which was treated by surgically assisted rapid maxillary expansion with satisfactory outcomes.

  10. Study of Class I and Class III Polyhydroxyalkanoate (PHA) Synthases with Substrates Containing a Modified Side Chain.

    Science.gov (United States)

    Jia, Kaimin; Cao, Ruikai; Hua, Duy H; Li, Ping

    2016-04-11

    Polyhydroxyalkanoates (PHAs) are carbon and energy storage polymers produced by a variety of microbial organisms under nutrient-limited conditions. They have been considered as an environmentally friendly alternative to oil-based plastics due to their renewability, versatility, and biodegradability. PHA synthase (PhaC) plays a central role in PHA biosynthesis, in which its activity and substrate specificity are major factors in determining the productivity and properties of the produced polymers. However, the effects of modifying the substrate side chain are not well understood because of the difficulty to accessing the desired analogues. In this report, a series of 3-(R)-hydroxyacyl coenzyme A (HACoA) analogues were synthesized and tested with class I synthases from Chromobacterium sp. USM2 (PhaCCs and A479S-PhaCCs) and Caulobacter crescentus (PhaCCc) as well as class III synthase from Allochromatium vinosum (PhaECAv). It was found that, while different PHA synthases displayed distinct preference with regard to the length of the alkyl side chains, they could withstand moderate side chain modifications such as terminal unsaturated bonds and the azide group. Specifically, the specific activity of PhaCCs toward propynyl analogue (HHxyCoA) was only 5-fold less than that toward the classical substrate HBCoA. The catalytic efficiency (kcat/Km) of PhaECAv toward azide analogue (HABCoA) was determined to be 2.86 × 10(5) M(-1) s(-1), which was 6.2% of the value of HBCoA (4.62 × 10(6) M(-1) s(-1)) measured in the presence of bovine serum albumin (BSA). These side chain modifications may be employed to introduce new material functions to PHAs as well as to study PHA biogenesis via click-chemistry, in which the latter remains unknown and is important for metabolic engineering to produce PHAs economically. PMID:26974339

  11. Decision making in the treatment of class III furcation: resective therapy? Extraction? Implant?

    Directory of Open Access Journals (Sweden)

    Antonio Wilson Sallum

    Full Text Available The presence of furcation lesions is associated with bone resorption and lack of insertion in the inter-radicular space, and is a condition that considerably increases the risk of dental loss, particularly in the absence of adequate treatment. In this context, the object of some of the therapies is to keep teeth with furcation lesions that are important to dental planning, to re-establish an anatomy that enables the patient to remove dental biofilm from the compromised area. However, the long term maintenance and treatment of molars with Class III furcation lesions continues to be a challenge to dentists during periodontal therapy, since the anatomy of the inter-radicular region makes it difficult for both professionals and patients to gain access to perform adequate and efficient control of dental biofilm. The impossibility of obtaining appropriate decontamination of the area involved during the root scraping process, including by means of surgical access, demands thatdentists have adequate knowledge to determine the correct therapeutic approach during the treatment of teeth with advance inter-radicularbone loss. The aim of the present study was to discuss the treatments available for Class III furcation lesions and relate clinical procedures that could be performed for the treatment of this type of defect.

  12. Assessment of temporomandibular disorder and occlusion in treated class III malocclusion patients

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    Karyna Valle-Corotti

    2007-04-01

    Full Text Available OBJECTIVE: The aims of this study were to compare the prevalence of temporomandibular disorders (TMD in individuals submitted to either orthodontic or ortho-surgical Class III malocclusion treatment and to assess the influence of occlusal aspects on TMD severity. MATERIAL AND METHODS: The sample consisted of 50 individuals divided into two groups, according to the type of treatment (orthodontic or orthodontic with orthognathic surgery. The presence of signs and symptoms of TMD was evaluated by an anamnestic questionnaire and a clinical examination, including TMJ and muscle palpation, active mandibular range of motion, joint noises and occlusal examination. RESULTS: Based on the anamnestic questionnaire, 48% had no TMD, 42% had mild TMD and 10% had moderate TMD. The presence and severity of TMD did not show any relationship with the type of orthodontic treatment (p>0.05. The chi-square test showed a positive association (p<0.05 between TMD and non-working side occlusal interferences. CONCLUSION: Based on the methodology used and the results obtained, it may be concluded that Class III orthodontic treatment was not associated with the presence of TMD signs and symptoms and the non-working side contacts can be occlusal factors of risk. There was no significant difference in TMD prevalence between the studied groups (orthodontically treated patients and patients treated with orthodontics followed by orthognathic surgery.

  13. Achados clínicos e polissonográficos em pacientes com obesidade classe III Clinical and polysomnographic findings in class III obese patients

    Directory of Open Access Journals (Sweden)

    Rodrigo de Paiva Tangerina

    2008-08-01

    Full Text Available A Síndrome da apnéia/hipopnéia obstrutiva do sono (SAHOS apresenta estreita correlação com a obesidade, porém não está estabelecida uma relação linear de gravidade principalmente em relação aos extremos como na obesidade mórbida. OBJETIVO: Avaliar os achados clínicos e polissonográficos em pacientes com obesidade classe III e correlacionar esses achados com a presença da SAHOS. MATERIAIS E MÉTODOS: Foram selecionados consecutivamente 45 pacientes com índice de massa corpórea superior a 40Kg/m2. Todos foram submetidos a anamnese, exame físico antropométrico e polissonografia. Os achados foram comparados entre os pacientes com e sem SAHOS. RESULTADOS: 68,9% dos pacientes eram do sexo feminino e 31,1% do masculino. A idade média foi de 46,5 DP 10,8 anos, a média do IMC foi 49 DP 7Kg/m2 e a média da circunferência cervical foi 43,4 DP 5,1cm. Todos os pacientes eram roncadores habituais e 48,9% tinham queixa de hipersonolência diurna. Os achados polissonográficos mostraram que 77,8% apresentaram índice de apnéia/hipopnéia superior a cinco. Apresentaram correlação com a presença da SAHOS: idade mais jovem (p=0,02 e maior circunferência cervical (p=0,004. CONCLUSÃO: A prevalência de SAHOS foi elevada, ressaltando a importância da sua investigação em pacientes referenciados para cirurgia bariátrica. O principal marcador da SAHOS foi a circunferência cervical.The Obstructive Sleep Apnea/Hipopnea Syndrome (OSAHS is closely related to obesity; a linear relation, however, has not been established, particularly in morbid obesity patients. AIM: To evaluate clinical and polysomnographic findings in a group of class III obese patients, and to relate these findings with the presence or absence of OSAHS. MATERIAL AND METHOD: Forty five patients with body mass indexex (BMI over 40Kg/m2 were selected consecutively. A clinical history, the anthropometric examination and polysomnography were undertaken in all patients. The

  14. Treatment of Class III malocclusion in a young adult patient: a case report.

    Science.gov (United States)

    Kiran, B H Jyothi; Kumar, Prashanth; Ravi, S; Shivalinga, B M; Bhagyalaxmi; Pradeep; Kudagi, Vishal

    2012-01-01

    This article describes the treatment of a young adult male with a concave profile, skeletal class III malocclusion because of a prognathic mandible and proclined upper incisors. The therapy included stages: 1. Pre-surgical orthodontics involving leveling and aligning of upper and lower arches, protraction of lower molars and retraction of upper incisors; 2. Surgical phase involving BSSO with mandibular setback and 3. Post-surgical orthodontics for finishing and detailing. The treatment lasted 23 months and improved facial esthetics significantly The treatment resulted in a functional occlusion with a lack of lateral cuspid guidance that could be accepted considering the difficulty of the case. Over jet and overbite are within norms. PMID:23094557

  15. Minimal presurgical orthodontics for a skeletal Class III patient with mandibular asymmetry.

    Science.gov (United States)

    Zhou, Yang; Zhou, Yanheng; Wang, Xiaoxia; Li, Zili

    2016-01-01

    A 19-year-old man with a skeletal Class III malocclusion was treated using minimal presurgical orthodontics. Orthodontic appliances and miniscrews were placed at the beginning of treatment, and the double-jaw-surgery was performed once the maxillary right and left first premolars were intruded, without worsening the concave profile and facial asymmetry presurgically. Different from the traditional combined orthodontic-orthognathic surgery, the jaw discrepancy was corrected first, followed by the orthodontic tooth movement. Miniscrews were used to intrude the premolars presurgically because of their interference and to provide the skeletal anchorage for intermaxillary elastics after the operation. The patient was pleased with the treatment results and satisfied with his facial and dental appearance, as well as his oral function. The 1-year follow-up photographs show a stable result both esthetically and functionally. PMID:26718384

  16. Prosthetic rehabilitation of severe Siebert′s Class III defect with modified Andrews bridge system

    Directory of Open Access Journals (Sweden)

    Manu Rathee

    2015-01-01

    Full Text Available Prosthetic dentistry involves the replacement of missing and contiguous tissues with artificial substitutes to restore and maintain the oral functions, appearance, and health of the patient. The treatment of edentulous areas with ridge defects poses a challenging task for the dentist. Management of such cases involves a wide range of treatment options comprising mainly of surgical interventions and non surgical techniques such as use of removable, fixed or fixed- removable partial dentures. But each treatment plan undertaken should be customized according to patient needs. A variety of factors such as quality and quantity of existing contiguous hard and soft tissues, systemic condition and economic status of the patient play an important role in treatment planning, clinical outcome and prognosis. This case report presents the restoration of a Seibert′s Class III ridge defect by an economical modification of Andrews Bridge in a 32 Year old patient.

  17. Prosthetic rehabilitation of severe Siebert's Class III defect with modified Andrews bridge system.

    Science.gov (United States)

    Rathee, Manu; Sikka, Neha; Jindal, Sahil; Kaushik, Ashutosh

    2015-03-01

    Prosthetic dentistry involves the replacement of missing and contiguous tissues with artificial substitutes to restore and maintain the oral functions, appearance, and health of the patient. The treatment of edentulous areas with ridge defects poses a challenging task for the dentist. Management of such cases involves a wide range of treatment options comprising mainly of surgical interventions and non surgical techniques such as use of removable, fixed or fixed- removable partial dentures. But each treatment plan undertaken should be customized according to patient needs. A variety of factors such as quality and quantity of existing contiguous hard and soft tissues, systemic condition and economic status of the patient play an important role in treatment planning, clinical outcome and prognosis. This case report presents the restoration of a Seibert's Class III ridge defect by an economical modification of Andrews Bridge in a 32 Year old patient. PMID:25821362

  18. Segmental LeFort I osteotomy for treatment of a class III malocclusion with temporomandibular disorder

    Directory of Open Access Journals (Sweden)

    Marcos Janson

    2008-08-01

    Full Text Available This article reports the case of a 19-year-old young man with Class III malocclusion and posterior crossbite with concerns about temporomandibular disorder (TMD, esthetics and functional problems. Surgical-orthodontic treatment was carried out by decompensation of the mandibular incisors and segmentation of the maxilla in 4 pieces, which allowed expansion and advancement. Remission of the signs and symptoms occurred after surgical-orthodontic intervention. The maxillary dental arch presented normal transverse dimension. Satisfactory static and functional occlusion and esthetic results were achieved and remained stable. Three years after the surgical-orthodontic treatment, no TMD sign or symptom was observed and the occlusal results had not changed. When vertical or horizontal movements of the maxilla in the presence of moderate maxillary constriction are necessary, segmental LeFort I osteotomy can be an important part of treatment planning.

  19. Complex networks for data-driven medicine: the case of Class III dentoskeletal disharmony

    International Nuclear Information System (INIS)

    In the last decade, the availability of innovative algorithms derived from complexity theory has inspired the development of highly detailed models in various fields, including physics, biology, ecology, economy, and medicine. Due to the availability of novel and ever more sophisticated diagnostic procedures, all biomedical disciplines face the problem of using the increasing amount of information concerning each patient to improve diagnosis and prevention. In particular, in the discipline of orthodontics the current diagnostic approach based on clinical and radiographic data is problematic due to the complexity of craniofacial features and to the numerous interacting co-dependent skeletal and dentoalveolar components. In this study, we demonstrate the capability of computational methods such as network analysis and module detection to extract organizing principles in 70 patients with excessive mandibular skeletal protrusion with underbite, a condition known in orthodontics as Class III malocclusion. Our results could possibly constitute a template framework for organising the increasing amount of medical data available for patients’ diagnosis. (paper)

  20. Structural diversity and transcription of class III peroxidases from Arabidopsis thaliana.

    Science.gov (United States)

    Welinder, Karen G; Justesen, Annemarie F; Kjaersgård, Inger V H; Jensen, Rikke B; Rasmussen, Søren K; Jespersen, Hans M; Duroux, Laurent

    2002-12-01

    Understanding peroxidase function in plants is complicated by the lack of substrate specificity, the high number of genes, their diversity in structure and our limited knowledge of peroxidase gene transcription and translation. In the present study we sequenced expressed sequence tags (ESTs) encoding novel heme-containing class III peroxidases from Arabidopsis thaliana and annotated 73 full-length genes identified in the genome. In total, transcripts of 58 of these genes have now been observed. The expression of individual peroxidase genes was assessed in organ-specific EST libraries and compared to the expression of 33 peroxidase genes which we analyzed in whole plants 3, 6, 15, 35 and 59 days after sowing. Expression was assessed in root, rosette leaf, stem, cauline leaf, flower bud and cell culture tissues using the gene-specific and highly sensitive reverse transcriptase-polymerase chain reaction (RT-PCR). We predicted that 71 genes could yield stable proteins folded similarly to horseradish peroxidase (HRP). The putative mature peroxidases derived from these genes showed 28-94% amino acid sequence identity and were all targeted to the endoplasmic reticulum by N-terminal signal peptides. In 20 peroxidases these signal peptides were followed by various N-terminal extensions of unknown function which are not present in HRP. Ten peroxidases showed a C-terminal extension indicating vacuolar targeting. We found that the majority of peroxidase genes were expressed in root. In total, class III peroxidases accounted for an impressive 2.2% of root ESTs. Rather few peroxidases showed organ specificity. Most importantly, genes expressed constitutively in all organs and genes with a preference for root represented structurally diverse peroxidases (< 70% sequence identity). Furthermore, genes appearing in tandem showed distinct expression profiles. The alignment of 73 Arabidopsis peroxidase sequences provides an easy access to the identification of orthologous peroxidases

  1. An innovative approach for correction of pseudo class III malocclusion with the use of "Planas direct tracks"

    Directory of Open Access Journals (Sweden)

    Ketan Sukumar Vora

    2013-01-01

    Full Text Available Anterior cross bite due to a pseudo Class III is a kind of malocclusion, which has a potential to turn into a facial deformity. This orthodontic emergency should be treated as soon as it is observed. A case of pseudo Class III was treated with Planas direct tracks (PDT. The PDT was designed such that the distal incline of the upper block occludes with mesial incline of the lower block such that the mandible will have a posterior path of closure with condyles in centric relation. Significant clinical change was seen in the subject. There was a significant reduction in mesial step and a considerable improvement in the facial profile. Cephalometrically, there was a significant increase seen in the lower anterior facial height. PDT is an efficient solution for the correction of early pseudo Class III malocclusion.

  2. The Quantum Mixed-Spin Heme State of Barley Peroxidase: A Paradigm for Class III Peroxidases

    Energy Technology Data Exchange (ETDEWEB)

    Howes, B.D.; Ma, J.; Marzocchi, M.P.; Schiodt, C.B.; Shelnutt, J.A.; Smulevich, G.; Welinder, K.G.; Zhang, J.

    1999-03-23

    Electronic absorption and resonance Raman (RR) spectra of the ferric form of barley grain peroxidase (BP 1) at various pH values both at room temperature and 20 K are . reported, together with EPR spectra at 10 K. The ferrous forms and the ferric complex with fluoride have also been studied. A quantum mechanically mixed-spin (QS) state has been identified. The QS heme species co-exists with 6- and 5-cHS heroes; the relative populations of these three spin states are found to be dependent on pH and temperature. However, the QS species remains in all cases the dominant heme spin species. Barley peroxidase appears to be further characterized by a splitting of the two vinyl stretching modes, indicating that the vinyl groups are differently conjugated with the porphyrin. An analysis of the presently available spectroscopic data for proteins from all three peroxidase classes suggests that the simultaneous occurrence of the QS heme state as well as the splitting of the two vinyl stretching modes is confined to class III enzymes. The former point is discussed in terms of the possible influences of heme deformations on heme spin state. It is found that moderate saddling alone is probably not enough to cause the QS state, although some saddling maybe necessary for the QS state.

  3. Long maximal incremental tests accurately assess aerobic fitness in class II and III obese men.

    Directory of Open Access Journals (Sweden)

    Stefano Lanzi

    Full Text Available This study aimed to compare two different maximal incremental tests with different time durations [a maximal incremental ramp test with a short time duration (8-12 min (STest and a maximal incremental test with a longer time duration (20-25 min (LTest] to investigate whether an LTest accurately assesses aerobic fitness in class II and III obese men. Twenty obese men (BMI≥35 kg.m-2 without secondary pathologies (mean±SE; 36.7±1.9 yr; 41.8±0.7 kg*m-2 completed an STest (warm-up: 40 W; increment: 20 W*min-1 and an LTest [warm-up: 20% of the peak power output (PPO reached during the STest; increment: 10% PPO every 5 min until 70% PPO was reached or until the respiratory exchange ratio reached 1.0, followed by 15 W.min-1 until exhaustion] on a cycle-ergometer to assess the peak oxygen uptake [Formula: see text] and peak heart rate (HRpeak of each test. There were no significant differences in [Formula: see text] (STest: 3.1±0.1 L*min-1; LTest: 3.0±0.1 L*min-1 and HRpeak (STest: 174±4 bpm; LTest: 173±4 bpm between the two tests. Bland-Altman plot analyses showed good agreement and Pearson product-moment and intra-class correlation coefficients showed a strong correlation between [Formula: see text] (r=0.81 for both; p≤0.001 and HRpeak (r=0.95 for both; p≤0.001 during both tests. [Formula: see text] and HRpeak assessments were not compromised by test duration in class II and III obese men. Therefore, we suggest that the LTest is a feasible test that accurately assesses aerobic fitness and may allow for the exercise intensity prescription and individualization that will lead to improved therapeutic approaches in treating obesity and severe obesity.

  4. Treatment of Multiple Adjacent Miller Class III Gingival Recessions with a Modified Tunnel Technique: A Case Series.

    Science.gov (United States)

    Yaman, Duygu; Demirel, Korkud; Aksu, Seden; Basegmez, Cansu

    2015-01-01

    Modified coronally advanced tunnel (MCAT) technique with connective tissue graft (CTG) was used in treating multiple adjacent Miller Class III gingival recessions in nine patients. Clinical evaluations were recorded at baseline and 12 months after surgery. The results showed that 50% of complete root coverage and 78% of mean root coverage were attained 1 year after surgery and interdental space fill was 73% at 12 months. The study demonstrated that CTG using the MCAT technique may be an efficient way to treat multiple adjacent Miller Class III gingival recessions, especially when aiming for interdental space fill. Success, however, seems to be related to the amount of tissue present initially.

  5. Miniscrew-assisted mandibular molar distalization in a patient with skeletal class-III malocclusion: A clinical case report

    Directory of Open Access Journals (Sweden)

    Seyed Mohammadreza Safavi

    2013-01-01

    Full Text Available In nongrowing patients with mild skeletal Class-III malocclusion, premolar extraction or molar distalization in the lower arch can be done as a part of camouflage treatment. Temporary anchorage devices are widely used for this purpose because they do not produce undesirable reciprocal effects and do not depend on the patient′s cooperation. However, most reported cases in this regard have used interradicular miniscrews in the mandibular arch and these have a risk of failure as they can loosen due to collision with adjacent roots. This article showcases mandibular molar distalization utilizing miniscrews, inserted at the retromolar area to correct a Class-III problem. A 24-year-old girl with a mild skeletal Class-III malocclusion and dental Class-III molar and canine relationship bilaterally was referred for orthodontic treatment. The treatment plan included distalization of the lower molars bilaterally followed by full fixed appliance therapy, after third molar extractions. For the lower molar distalization, the miniscrews were inserted at the retromolar pad. At the end of 21 months, a Class-I molar and canine relationship, normal overjet and overbite were obtained. The average amount of distalization of mandibular first molar was 3.2 mm at the crown level. In conclusion, placing miniscrews at the retromolar pad area for lower molar distalization was found to be a simple and effective method for correcting anterior cross bite and mandibular anterior crowding or protrusion, without the need for patient compliance.

  6. Self-esteem in adolescents with Angle Class I, II and III malocclusion in a Peruvian sample

    Directory of Open Access Journals (Sweden)

    Karla Florián-Vargas

    2016-04-01

    Full Text Available ABSTRACT Objective: To compare self-esteem scores in 12 to 16-year-old adolescents with different Angle malocclusion types in a Peruvian sample. Material and Methods: A cross-sectional study was conducted in a sample of 276 adolescents (159, 52 and 65 with Angle Class I, II and III malocclusions, respectively from Trujillo, Peru. Participants were asked to complete the Rosenberg Self-Esteem Scale (RSES and were also clinically examined, so as to have Angle malocclusion classification determined. Analysis of covariance (ANCOVA was used to compare RSES scores among adolescents with Class I, II and III malocclusions, with participants' demographic factors being controlled. Results: Mean RSES scores for adolescents with Class I, II and III malocclusions were 20.47 ± 3.96, 21.96 ± 3.27 and 21.26 ± 4.81, respectively. The ANCOVA test showed that adolescents with Class II malocclusion had a significantly higher RSES score than those with Class I malocclusion, but there were no differences between other malocclusion groups. Supplemental analysis suggested that only those with Class II, Division 2 malocclusion might have greater self-esteem when compared to adolescents with Class I malocclusion. Conclusion: This study shows that, in general, self-esteem did not vary according to adolescents' malocclusion in the sample studied. Surprisingly, only adolescents with Class II malocclusion, particularly Class II, Division 2, reported better self-esteem than those with Class I malocclusion. A more detailed analysis assessing the impact of anterior occlusal features should be conducted.

  7. Semi-longitudinal Study of the Mcnamara Cephalometric Triangle in Class II and Class III Subjects Grouped by Cervical Vertebrae Maturation Stage.

    Science.gov (United States)

    Arriola-Guillén, Luis E; Fitzcarrald, Fernando D; Flores-Mir, Carlos

    2015-12-01

    The aim was to compare the McNamara cephalometric triangle values in untreated normodivergent Class II and Class III malocclusion subjects of Latin American origin grouped by cervical vertebrae maturation stage to an untreated Class I malocclusion normodivergent control group. The study was conducted on a sample of 610 pretreatment lateral cephalograms (250 male, 360 female), examined and grouped according to their anteroposterior skeletal relationship (Class I, II or III), cervical vertebrae maturation stage (Pre Pubertal Peak P1 = CS1 and CS2, Pubertal Peak P2= CS3 and CS4, and Post Pubertal Peak P3 = CS5 and CS6) and sex. Co-A, Co-Gn and ENA-Me were measured in each lateral cephalogram. ANOVA and Tukey HSD post-hoc tests were performed to determine differences between the groups. The results showed that in males, the greatest maxillary and mandibular dimensional increases occurred during the P3 stage (CS5 to CS6), while in females, they occurred in the P2 stage (CS3 to CS4). The Co-A and Co-Gn showed significant differences between the malocclusion classes (pMcNamara cephalometric triangle values were markedly different in the three normodivergent skeletal malocclusion classes. In these Latin American subjects the pubertal growth spurt occurred at different times with respect to the Caucasian and Asian norms.

  8. Cirurgia ortognática: abordagem psicossocial em pacientes Classe III de Angle submetidos à correção cirúrgica da deformidade dentofacial Orthognathic surgery: psychosocial approach in Angle Class III patients submitted to correction surgery of facial deformity

    Directory of Open Access Journals (Sweden)

    Denise Nicodemo

    2007-10-01

    Full Text Available OBJETIVO: investigar aspectos psicossociais relacionados à mudança da aparência facial em 29 pacientes, de ambos os gêneros, com idades entre 17 e 46 anos, com indicação de tratamento cirúrgico, nos períodos pré-operatório (durante preparo ortodôntico e pós-operatório (transcorridos 6 meses da intervenção cirúrgica. MÉTODOS: utilizou-se questionários, aplicados na forma de entrevistas, com perguntas baseadas na proposta de Grossbart e Sarwer. Utilizou-se a técnica de análise de conteúdo, representando-se o motivo da procura pela correção cirúrgica em Categoria 1 (C1; as fantasias relacionadas aos resultados da correção cirúrgica (pré-operatório e realização (pós-operatório em Categoria 2 (C2; e as expectativas e a satisfação quanto aos resultados da correção cirúrgica em Categoria 3 (C3. As respostas foram reagrupadas nas subcategorias: estética (SC1, funcional (SC2, situações sociais (SC3, auto-estima (SC4 e profissional (SC5. RESULTADOS: os resultados indicaram que os pacientes procuraram a correção cirúrgica por motivos funcionais (34,5%, estéticos (30,9% e sociais (29,1%; desejavam melhorar as situações sociais (40% e a estética (32%, com realização destes desejos, depois da cirurgia. Quanto às expectativas, 49,4% dos pacientes esperavam melhorar o aspecto funcional, seguido da estética (26,9%, situações sociais (11,2% e auto-estima (6,7%. Em todos os aspectos, os pacientes ficaram muito satisfeitos pela melhora na dicção, na estética, na beleza e no retorno à vida sem discriminação. CONCLUSÕES: os pacientes procuraram a correção cirúrgica motivados a melhorar o aspecto funcional e a estética; fantasiavam melhorar as relações sociais e a aparência; esperavam, de forma realista, que a correção cirúrgica reparasse a função e a estética - objetivos propostos pela cirurgia ortognática.AIM: The purpose of this work was to investigate the psychosocial aspects related to facial changes in 29 patients, from both genres, between 17 and 46 years old, with indication of surgical treatment, in the preoperative (during orthodontic preparation and in the postoperative (six months after the surgery periods. METHODS: Questionnaires, applied during interviews, with questions based on the proposal by Grossbart & Sarwer were used. The technique of content analysis was used, in which the reason for choosing corrective surgery were represented in Category 1 (C1; fantasies related to the results of the corrective surgery (preoperative and performance (postoperative in Category 2 (C2; and expectations and satisfaction of the results of the corrective surgery in Category 3 (C3. The answers were grouped in the subcategories: aesthetics (SC1, functional (SC2, social situations (SC3, self-esteem (SC4 and professional (SC5. RESULTS: the results showed that the patients looked for corrective surgery for functional reasons (34.5%, aesthetics (30.9% and social (29.1%; wished to improve his/her social situation (40% and the aesthetics (32%, with the fulfillment of these wishes after the surgery. As for the expectations, 49.4% of the patients hoped to improve the functional aspect followed by aesthetics (26.9%; social situations (11.2% and self-esteem (6.7%. In all aspects the patients were very satisfied because of improvements in their diction, aesthetics, beauty, and the return to life without discrimination. CONCLUSIONS: It can be concluded that the patients looked for the corrective surgery with the motivation to improve their functional and aesthetics aspects, they fantasized to improve their social relations and appearance; and hoped, in a realistic way, that the corrective surgery would repaired the function and aesthetics - which are the objectives of the orthognathic surgery.

  9. Class III β-tubulin in advanced NSCLC of adenocarcinoma subtype predicts superior outcome in a randomized trial

    DEFF Research Database (Denmark)

    Vilmar, Adam Christian; Santoni-Rugiu, Eric; Sørensen, Jens Benn

    2011-01-01

    Platinum-based doublets are the cornerstone of treatment in advanced non-small-cell lung cancer (NSCLC) and often include vinorelbine or taxanes. A predictive biomarker is greatly needed to select chemotherapy-sensitive patients for these microtubule-interfering agents. Class III ß-tubulin (TUBB3...

  10. Class III β-tubulin in advanced NSCLC of adenocarcinoma subtype predicts superior outcome in a randomized trial

    DEFF Research Database (Denmark)

    Vilmar, Adam Christian; Santoni-Rugiu, Eric; Sørensen, Jens Benn

    2011-01-01

    Platinum-based doublets are the cornerstone of treatment in advanced non-small-cell lung cancer (NSCLC) and often include vinorelbine or taxanes. A predictive biomarker is greatly needed to select chemotherapy-sensitive patients for these microtubule-interfering agents. Class III β-tubulin (TUBB3...

  11. The anaerobic (Class III) ribonucleotide reductase from Lactococcus lactis : Catalytic properties and allosteric regulation of the pure enzyme system

    NARCIS (Netherlands)

    Torrents, Eduard; Buist, Girbe; Liu, Aimin; Eliasson, Rolf; Kok, Jan; Gibert, Isidre; Gräslund, Astrid; Reichard, Peter

    2000-01-01

    Lactococcus lactis contains an operon with the genes (nrdD and nrdG) for a class III ribonucleotide reductase, Strict anaerobic growth depends on the activity of these genes. Both were sequenced, cloned, and overproduced in Escherichia coli, The corresponding proteins, NrdD and NrdG, were purified c

  12. Proteomics computational analyses suggest that the bornavirus glycoprotein is a class III viral fusion protein (γ penetrene

    Directory of Open Access Journals (Sweden)

    Garry Robert F

    2009-09-01

    Full Text Available Abstract Background Borna disease virus (BDV is the type member of the Bornaviridae, a family of viruses that induce often fatal neurological diseases in horses, sheep and other animals, and have been proposed to have roles in certain psychiatric diseases of humans. The BDV glycoprotein (G is an extensively glycosylated protein that migrates with an apparent molecular mass of 84,000 to 94,000 kilodaltons (kDa. BDV G is post-translationally cleaved by the cellular subtilisin-like protease furin into two subunits, a 41 kDa amino terminal protein GP1 and a 43 kDa carboxyl terminal protein GP2. Results Class III viral fusion proteins (VFP encoded by members of the Rhabdoviridae, Herpesviridae and Baculoviridae have an internal fusion domain comprised of beta sheets, other beta sheet domains, an extended alpha helical domain, a membrane proximal stem domain and a carboxyl terminal anchor. Proteomics computational analyses suggest that the structural/functional motifs that characterize class III VFP are located collinearly in BDV G. Structural models were established for BDV G based on the post-fusion structure of a prototypic class III VFP, vesicular stomatitis virus glycoprotein (VSV G. Conclusion These results suggest that G encoded by members of the Bornavirdae are class III VFPs (gamma-penetrenes.

  13. 40 CFR 147.2400 - State-administered program-Class I, II, III, IV, and V wells.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false State-administered program-Class I, II, III, IV, and V wells. 147.2400 Section 147.2400 Protection of Environment ENVIRONMENTAL PROTECTION... between the Washington Department of Ecology and Department of Social and Health Services, Related to...

  14. [Limiting factors in the class III camouflage treatment: a potential protocol].

    Science.gov (United States)

    Chaques Asensi, José

    2016-06-01

    The Class III skeletal malocclusion has been traditionally treated with a combined approach of orthodontics and orthognathic surgery or with a strategy of orthodontic camouflage. Some severe cases can be identified as ideal candidates for a surgical treatment whereas some others can be handled with orthodontics alone, with a reasonable expectation of an acceptable result. However, the problem remains for the borderline patient. In fact, limited information is available in the literature regarding the identification of the factors that can help in establishing the limits for one treatment modality or the other. Furthermore, the quantification of some of these factors, for practical purposes, is practically missing or very seldom suggested. Therefore, the decision making process remains a subjective reflection based on the "good clinical sense" of the orthodontist or just reduced to an "educated guess". In order to add some information, hopefully useful in deciding the most suitable treatment option for the individual patient, we propose a clinical protocol based on four different factors. Namely: the skeletal discrepancy, the occlusal discrepancy, the periodontal condition and facial aesthetics. For each one of these factors several parameters will be evaluated and, for some of them, an attempt to provide some reference numerical values will be made. Finally, clinical examples will be presented to illustrate the concepts discussed and the treatment alternatives, final treatment plan and treatment outcome will be analyzed for each one of them. PMID:27358006

  15. Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.

    Science.gov (United States)

    Lelli, Andrea; Michel, Vincent; Boutet de Monvel, Jacques; Cortese, Matteo; Bosch-Grau, Montserrat; Aghaie, Asadollah; Perfettini, Isabelle; Dupont, Typhaine; Avan, Paul; El-Amraoui, Aziz; Petit, Christine

    2016-01-18

    The precise architecture of hair bundles, the arrays of mechanosensitive microvilli-like stereocilia crowning the auditory hair cells, is essential to hearing. Myosin IIIa, defective in the late-onset deafness form DFNB30, has been proposed to transport espin-1 to the tips of stereocilia, thereby promoting their elongation. We show that Myo3a(-/-)Myo3b(-/-) mice lacking myosin IIIa and myosin IIIb are profoundly deaf, whereas Myo3a-cKO Myo3b(-/-) mice lacking myosin IIIb and losing myosin IIIa postnatally have normal hearing. Myo3a(-/-)Myo3b(-/-) cochlear hair bundles display robust mechanoelectrical transduction currents with normal kinetics but show severe embryonic abnormalities whose features rapidly change. These include abnormally tall and numerous microvilli or stereocilia, ungraded stereocilia bundles, and bundle rounding and closure. Surprisingly, espin-1 is properly targeted to Myo3a(-/-)Myo3b(-/-) stereocilia tips. Our results uncover the critical role that class III myosins play redundantly in hair-bundle morphogenesis; they unexpectedly limit the elongation of stereocilia and of subsequently regressing microvilli, thus contributing to the early hair bundle shaping.

  16. Impact of physical activity and fitness in class II and III obese individuals: a systematic review.

    Science.gov (United States)

    Baillot, A; Audet, M; Baillargeon, J P; Dionne, I J; Valiquette, L; Rosa-Fortin, M M; Abou Chakra, C N; Comeau, E; Langlois, M F

    2014-09-01

    The objective of this systematic review was to appraise current knowledge on the impact of physical activity (PA) and physical fitness (PF) on the health of class II and III obese subjects and bariatric surgery (BS) patients. All original studies were searched using four databases (Medline®, Scopus®, CINAHL and Sportdiscus). Two independent investigators selected studies assessing the impact of PA or PF on specific health outcomes (anthropometric parameters, body composition, cardiometabolic risk factors, PF, wellness) in adults with a body mass index ≥35 kg m(-2) or in BS patients. Conclusions were drawn based on a rating system of evidence. From 3,170 papers identified, 40 papers met the inclusion criteria. The vast majority of studies were recently carried out with a predominance of women. Less than one-third of these studies were experimental and only three of them were of high quality. Each study reported at least one beneficial effect of PA or PF. However, a lack of high-quality studies and heterogeneity in designs prevented us from finding high levels of evidence. In conclusion, although results support the importance of PA and PF to improve the health of this population, higher-quality trials are required to strengthen evidence-based recommendations. PMID:24712685

  17. Cephalometric evaluation of class-III patients with chin cap and tongue guard.

    Science.gov (United States)

    Danaie, S M; Salehi, P

    2005-06-01

    The purpose of this study was to determine the effect of chin cap therapy combined with an upper tongue guard in the early treatment of class-III malocclusion on the nasomaxillary complex and mandible. The subjects of this study consisted of 40 patients aged 5-13 years (mean age of 8.5 +/- 2). All of them possessed an anterior cross bite and/or concave profile. The mean force of chin cap was determined to be 200 g on each side for 18 h/day and the mean treatment period was 22 months. The cephalometric analyses including skeletal, dental, and soft tissue analysis were carried out before and after treatment. The analysis of the cephalometric measurements revealed a negative correlation between the combination effects of chin cap therapy upper tongue guard. This effect appeared in the early stages of treatment. It was a case-control study and Wilcoxon test was used for statistical analysis. The comparison of dependent variables revealed that skeletal effects of chin cap therapy were more than dental and soft tissue effects. Changes in the upper and lower pharyngeal spaces were not significant. A reduction of nasolabial angle occurred due to the protrusion of upper incisors. Finally, it was shown that the combination of chin cap and upper tongue guard could be more effective in the early treatment.

  18. A vacuolar class III peroxidase and the metabolism of anticancer indole alkaloids in Catharanthus roseus

    Science.gov (United States)

    Duarte, Patrícia; Figueiredo, Raquel; Ros Barceló, Alfonso

    2008-01-01

    Plants possess a unique metabolic diversity commonly designated as secondary metabolism, of which the anticancer alkaloids from Catharanthus roseus are among the most studied. Recently, in a classical function-to-protein-to-gene approach, we have characterized the main class III peroxidase (Prx) expressed in C. roseus leaves, CrPrx1, implicated in a key biosynthetic step of the anticancer alkaloids. We have shown the vacuolar sorting determination of CrPrx1 using GFP fusions and we have obtained further evidence supporting the role of this enzyme in alkaloid biosynthesis, indicating the potential of CrPrx1 as a molecular tool for the manipulation of alkaloid metabolism. Here, we discuss how plant cells may regulate Prx reactions. In fact, Prxs form a large multigenic family whose members accept a broad range of substrates and, in their two subcellular localizations, the cell wall and the vacuole, Prxs co-locate with a large variety of secondary metabolites which can be accepted as substrates. How then, are Prx reactions regulated? Localization data obtained in our lab suggest that arabinogalactan proteins (AGPs) and Prxs may be associated in membrane microdomains, evocative of lipid rafts. Whether plasma membrane and/or tonoplast microcompartmentation involve AGPs and Prxs and whether this enables metabolic channeling determining Prx substrate selection are challenging questions ahead. PMID:19704535

  19. A Morphological Study on the Relationship between Arch Form and Craniofacial Structures in Skeletal Class I and Class III Japanese Patient

    OpenAIRE

    NARUZAWA, ROBERTA MIYOE; MINOSHIMA, YASUHIRO; KAGEYAMA, TORU; Deguchi, Toshio; KURIHARA, SABURO

    1999-01-01

    Available studies about differences among races, related to prevalence of malocclusion or morphology of head and dental arches, suggest a hypothesis that the high prevalence of skeletal Class III malocclusion in Asian ancestry populations could be correlated with a tendency toward a brachycephalic head form and larger arches widths. The purpose of the present study was to evaluate anteroposterior relationship of upper and lower jaws associated to form of dental arches, maxilla, mandible, face...

  20. Má oclusão Classe III de Angle, subdivisão direita, tratada sem exodontias e com controle de crescimento Angle Class III malocclusion, subdivision right, treated without extractions and with growth control

    Directory of Open Access Journals (Sweden)

    Sérgio Henrique Casarim Fernandes

    2010-12-01

    Full Text Available A Classe III de Angle é uma má oclusão caracterizada por discrepâncias anteroposteriores dentárias e faciais, normalmente acompanhadas por alterações esqueléticas, com componente genético associado. O diagnóstico precoce e correto e o tratamento adequado são de suma importância para promover o controle do crescimento e evitar recidivas. Este artigo relata o tratamento, executado em duas fases, de uma paciente do sexo feminino de 12 anos de idade, apresentando uma má oclusão de Classe III de Angle, subdivisão direita, com mordida cruzada anterior em máxima intercuspidação habitual (MIH e topo em relação cêntrica (RC, apresentando, ainda, falta de espaço na maxila, que foi tratada sem exodontias e com controle de crescimento. Esse caso foi apresentado à Diretoria do Board Brasileiro de Ortodontia e Ortopedia Facial (BBO, representando a categoria 1, ou seja, uma má oclusão Classe III de Angle, tratada sem exodontias e com controle de crescimento, como parte dos requisitos para a obtenção do título de Diplomado pelo BBOAngle Class III malocclusion is characterized by anteroposterior dental and facial discrepancies usually accompanied by skeletal changes associated with a genetic component. Early, accurate diagnosis and appropriate treatment are of paramount importance to promote growth control and prevent relapse. This article reports the two-phase treatment of a female patient, aged 12 years, with an Angle Class III, subdivision right malocclusion with anterior crossbite in maximum intercuspation (MIC and end-on bite in centric relation, further presenting with lack of maxillary space. The case was treated without extractions and with growth control. This case was presented to the Brazilian Board of Orthodontics and Facial Orthopedics (BBO as representative of Category 1, i.e., Angle Class III malocclusion treated without tooth extractions, as part of the requirements for obtaining the BBO Diploma

  1. Asymmetric molar distalization with miniscrews to correct a severe unilateral Class III malocclusion.

    Science.gov (United States)

    Ma, Qiao Ling; Conley, R Scott; Wu, Tuojiang; Li, Huang

    2016-05-01

    Asymmetries are among the most challenging problems in orthodontics. Proper diagnosis is critical to discern first whether the asymmetry is dental or skeletal. If it is dental, one must then determine whether one dental arch or both are at fault. Once diagnosed, the next challenge is determining not only an appropriate treatment plan, but also the appropriate mechanics plan. This aim of this article is to present a patient with a severe asymmetry to emphasize the importance of a problem-based differential diagnosis to develop both a sound treatment plan and a mechanics plan that successfully integrates miniscrews from the start of the process. An 18-year-old woman had a Class III subdivision left malocclusion, an asymmetric lower facial third, and a deviated midline. The treatment plan consisted of asymmetric distalization of the maxillary right and mandibular left posterior dentitions to create space to resolve the deviated midlines, correct the canted occlusal plane, and obtain an ideal occlusion. Active treatment with Clarity ceramic 0.022 × 0.028-in appliances (3M Unitek, Monrovia, Calif), temporary anchorage devices, and a pendulum appliance lasted 22 months. The final result and the 2-year retention records demonstrate that a harmonious facial balance, an attractive smile, ideal occlusal relationships, and a stable outcome were achieved. This case report shows that with proper planning, asymmetric use of temporary anchorage devices in multiple posterior quadrants can be used to obtain molar distalization, and this approach is an effective alternative to dental extraction therapy. PMID:27131255

  2. Molecular characterization of fruit-specific class III peroxidase genes in tomato (Solanum lycopersicum).

    Science.gov (United States)

    Wang, Chii-Jeng; Chan, Yuan-Li; Shien, Chin Hui; Yeh, Kai-Wun

    2015-04-01

    In this study, expression of four peroxidase genes, LePrx09, LePrx17, LePrx35 and LePrxA, was identified in immature tomato fruits, and the function in the regulation of fruit growth was characterized. Analysis of amino acid sequences revealed that these genes code for class III peroxidases, containing B, D and F conserved domains, which bind heme groups, and a buried salt bridge motif. LePrx35 and LePrxA were identified as novel peroxidase genes in Solanum lycopersicum (L.). The temporal expression patterns at various fruit growth stages revealed that LePrx35 and LePrxA were expressed only in immature green (IMG) fruits, whereas LePrx17 and LePrx09 were expressed in both immature and mature green fruits. Tissue-specific expression profiles indicated that only LePrx09 was expressed in the mesocarp but not the inner tissue of immature fruits. The effects of hormone treatments and stresses on the four genes were examined; only the expression levels of LePrx17 and LePrx09 were altered. Transcription of LePrx17 was up-regulated by jasmonic acid (JA) and pathogen infection and expression of LePrx09 was induced by ethephon, salicylic acid (SA) and JA, in particular, as well as wounding, pathogen infection and H2O2 stress. Tomato plants over-expressing LePrx09 displayed enhanced resistance to H2O2 stress, suggesting that LePrx09 may participate in the H2O2 signaling pathway to regulate fruit growth and disease resistance in tomato fruits. PMID:25703772

  3. Extreme Dental Compensation in an Adult Skeletal Class III Malocclusion: 3-Year Follow-up of a Successfully Compromised Treatment.

    Science.gov (United States)

    Estelita, Sérgio; Janson, Guilherme; Chiqueto, Kelly

    2015-01-01

    Nonsurgical orthodontic treatment of a patient with severe skeletal Class III malocclusion, negative overjet, increased overbite and maxillary crowding is described Although the treatment options included an orthodontic-surgical approach, high cost of the surgical procedure was the main reason for extreme dental compensation to have been performed. Four-premolar extraction protocol associated with intermaxillary Class III elastics were used to correct the malocclusion at the expense of increasing the initial dental compensation without producing any noticeable skeletal change. Satisfactory and stable occlusion was achieved with dental and smile esthetics improvement, but the amount of facial changes was limited by the nonsurgical protocol. The clinical results and implications of compensatory treatment as well as its relevance within the patient context are discussed based on scientific evidences. PMID:26349294

  4. Class III obesity and unwanted pregnancy among women with live births in New York City, 2004-2007.

    Science.gov (United States)

    Garbers, Samantha; Chiasson, Mary Ann

    2013-10-01

    Obesity is associated with numerous adverse health effects for pregnant women and their newborns. Unintended pregnancy is associated with suboptimal prenatal health behaviors and adverse birth outcomes. While research has suggested a link between obesity and unintended pregnancy, the evidence has been contradictory. Research has not focused on women at the highest level of obesity, Class III (body mass index ≥40). Pregnancy Risk Assessment Monitoring System data for 4,161 women in New York City with a live birth from 2004 to 2007 and complete data on pregnancy intention, height, and weight were examined. The primary outcome, having a live birth that resulted from an unwanted pregnancy (not wanted at that time or at any time in the future), was compared across 6 groups of pre-pregnancy body mass index (BMI). Logistic regression models adjusting for sociodemographic factors and stressors during pregnancy were conducted. The proportion of women reporting their pregnancy was unwanted increased with increasing BMI level to a high of 24 % among women with Class III obesity. After adjustment for confounding sociodemographic factors, women classified as Class III obese were significantly more likely than women with normal BMI to report an unwanted pregnancy [AOR = 2.81 (95 % CI: 1.41-5.60)]; this relationship held after adjusting for stressors during pregnancy. No significant association was found for women of other BMI groups. Previous analyses may have masked a relationship between BMI and unwanted pregnancy among women with Class III obesity. Further research exploring underlying mechanisms which are amenable to intervention is of critical public health importance.

  5. Accuracy of Dolphin visual treatment objective (VTO) prediction software on class III patients treated with maxillary advancement and mandibular setback

    OpenAIRE

    Peterman, Robert J.; Jiang, Shuying; Johe, Rene; Mukherjee, Padma M.

    2016-01-01

    Background Dolphin® visual treatment objective (VTO) prediction software is routinely utilized by orthodontists during the treatment planning of orthognathic cases to help predict post-surgical soft tissue changes. Although surgical soft tissue prediction is considered to be a vital tool, its accuracy is not well understood in tow-jaw surgical procedures. The objective of this study was to quantify the accuracy of Dolphin Imaging’s VTO soft tissue prediction software on class III patients tre...

  6. Conservative treatment for a growing patient with a severe, developing skeletal Class III malocclusion and open bite.

    Science.gov (United States)

    Xu, Yue; Zhu, Ping; Le, Linda; Cai, Bin

    2014-06-01

    An 8-year-old Chinese girl sought treatment for a severe skeletal Class III malocclusion and open-bite skeletal pattern. Traditionally, patients with a skeletal Class III malocclusion are treated after they have stopped growing, and then they are treated with a combined orthodontic and orthognathic surgery approach. But the risks and expenses of this treatment plan are not acceptable to all patients. This young patient was treated with facemask therapy, a maxillary expansion device, and a molar occlusal splint for maxillary developmental stimulation with control of vertical jaw growth. After the completion of orthopedic therapy, 2 × 4 technology was used to adjust molar positions. A bonded tongue crib was used in the early permanent dentition to help the patient break her bad tongue habits. Straight-wire appliances were used for 16 months to adjust the occlusal relationship. This achieved significant improvement in anterior tooth relationships and facial profile esthetics. At the 2-year posttreatment follow-up, the results were satisfactory. The success of the sagittal relationship correction between the maxilla and the mandible for a skeletal Class III malocclusion depends on the coordination of transverse and vertical relationships combined with the growth potential of each patient.

  7. Structure of putrescine aminotransferase from Escherichia coli provides insights into the substrate specificity among class III aminotransferases.

    Directory of Open Access Journals (Sweden)

    Hyung Jin Cha

    Full Text Available YgjG is a putrescine aminotransferase enzyme that transfers amino groups from compounds with terminal primary amines to compounds with an aldehyde group using pyridoxal-5'-phosphate (PLP as a cofactor. Previous biochemical data show that the enzyme prefers primary diamines, such as putrescine, over ornithine as a substrate. To better understand the enzyme's substrate specificity, crystal structures of YgjG from Escherichia coli were determined at 2.3 and 2.1 Å resolutions for the free and putrescine-bound enzymes, respectively. Sequence and structural analyses revealed that YgjG forms a dimer that adopts a class III PLP-dependent aminotransferase fold. A structural comparison between YgjG and other class III aminotransferases revealed that their structures are similar. However, YgjG has an additional N-terminal helical structure that partially contributes to a dimeric interaction with the other subunit via a helix-helix interaction. Interestingly, the YgjG substrate-binding site entrance size and charge distribution are smaller and more hydrophobic than other class III aminotransferases, which suggest that YgjG has a unique substrate binding site that could accommodate primary aliphatic diamine substrates, including putrescine. The YgjG crystal structures provide structural clues to putrescine aminotransferase substrate specificity and binding.

  8. South European Journal of Orthodontics and Dentofacial Research: A new hope

    OpenAIRE

    Lauc, Tomislav

    2014-01-01

    Welcome to South European Journal of Orthodontics and Dentofacial Research. Today, orthodontics is different. In the last twenty years technology has posed new challenges not only for orthodontics but for all fields of dental medicine, and science in general. Technological progress is also creating new opportunities in research with new study designs and new questions, opening space for re-evaluating present paradigms and creating new ideas in perceiving basics of orthodontic, pedodontic ...

  9. Regulation of the Tumor-Suppressor Function of the Class III Phosphatidylinositol 3-Kinase Complex by Ubiquitin and SUMO

    Energy Technology Data Exchange (ETDEWEB)

    Reidick, Christina [Biochemie Intrazellulärer Transportprozesse, Ruhr-Universität Bochum, Bochum 44801 (Germany); El Magraoui, Fouzi; Meyer, Helmut E. [Biomedical Research, Human Brain Proteomics II, Leibniz-Institut für Analytische Wissenschaften-ISAS, Dortmund 44139 (Germany); Stenmark, Harald [Department of Biochemistry, Institute for Cancer Research, Oslo University Hospital, Montebello, Oslo 0310 (Norway); Platta, Harald W., E-mail: harald.platta@rub.de [Biochemie Intrazellulärer Transportprozesse, Ruhr-Universität Bochum, Bochum 44801 (Germany)

    2014-12-23

    The occurrence of cancer is often associated with a dysfunction in one of the three central membrane-involution processes—autophagy, endocytosis or cytokinesis. Interestingly, all three pathways are controlled by the same central signaling module: the class III phosphatidylinositol 3-kinase (PI3K-III) complex and its catalytic product, the phosphorylated lipid phosphatidylinositol 3-phosphate (PtdIns3P). The activity of the catalytic subunit of the PI3K-III complex, the lipid-kinase VPS34, requires the presence of the membrane-targeting factor VPS15 as well as the adaptor protein Beclin 1. Furthermore, a growing list of regulatory proteins associates with VPS34 via Beclin 1. These accessory factors define distinct subunit compositions and thereby guide the PI3K-III complex to its different cellular and physiological roles. Here we discuss the regulation of the PI3K-III complex components by ubiquitination and SUMOylation. Especially Beclin 1 has emerged as a highly regulated protein, which can be modified with Lys11-, Lys48- or Lys63-linked polyubiquitin chains catalyzed by distinct E3 ligases from the RING-, HECT-, RBR- or Cullin-type. We also point out other cross-links of these ligases with autophagy in order to discuss how these data might be merged into a general concept.

  10. Class III β-tubulin overexpression within the tumor microenvironment is a prognostic biomarker for poor overall survival in ovarian cancer patients treated with neoadjuvant carboplatin/paclitaxel

    OpenAIRE

    Roque, Dana M; Buza, Natalia; Glasgow, Michelle; Bellone, Stefania; Bortolomai, Ileana; Gasparrini, Sara; Cocco, Emiliano; Ratner, Elena; Silasi, Dan-Arin; Azodi, Masoud; Rutherford, Thomas J.; Schwartz, Peter E.; Alessandro D Santin

    2013-01-01

    Critics have suggested that neoadjuvant chemotherapy (NACT) followed by interval debulking may select for resistant clones or cancer stem cells when compared to primary cytoreduction. β-tubulins are chemotherapeutic targets of taxanes and epothilones. Class III β-tubulin overexpression has been linked to chemoresistance and hypoxia. Herein, we describe changes in class III β-tubulin in patients with advanced ovarian carcinoma in response to NACT, in relationship to clinical outcome, and betwe...

  11. Effects of Lifestyle Interventions That Include a Physical Activity Component in Class II and III Obese Individuals: A Systematic Review and Meta-Analysis

    OpenAIRE

    Baillot, Aurélie; Romain, Ahmed J.; Boisvert-Vigneault, Katherine; Audet, Mélisa; Baillargeon, Jean Patrice; Dionne, Isabelle J.; Valiquette, Louis; Chakra, Claire Nour Abou; Avignon, Antoine; Langlois, Marie-France

    2015-01-01

    Background In class II and III obese individuals, lifestyle intervention is the first step to achieve weight loss and treat obesity-related comorbidities before considering bariatric surgery. A systematic review, meta-analysis, and meta-regression were performed to assess the impact of lifestyle interventions incorporating a physical activity (PA) component on health outcomes of class II and III obese individuals. Methods An electronic search was conducted in 4 databases (Medline, Scopus, CIN...

  12. Mechanistic investigation of food effect on disintegration and dissolution of BCS class III compound solid formulations: the importance of viscosity.

    Science.gov (United States)

    Radwan, Asma; Amidon, Gordon L; Langguth, Peter

    2012-10-01

    A negative food effect, i.e. a decrease in bioavailability upon the co-administration of compounds together with food, has been attributed particularly with high solubility/low permeability compounds (BCS class III). Different mechanisms have been proposed including intestinal dilution leading to a lower concentration gradient across the intestinal wall as well as binding of the active pharmaceutical ingredient to food components in the intestine and thereby decreasing the fraction of the dose available for absorption. These mechanisms refer primarily to the compound and not to the dosage form. An increase in viscosity of the dissolution fluid will in particular affect the absorption of BCS type III compounds with preferential absorption in the upper small intestine if the API release is delayed from the dosage form. The present study demonstrated that the increase in viscosity of the dissolution medium, following ingestion of a solid meal, may drastically reduce disintegration and dissolution. For that purpose the viscosity of the standard FDA meal was determined and simulated by solutions of HPMC in buffer. As model formulations, three commercially available tablets containing trospium chloride, a BCS class III m-cholinoreceptor antagonist was used. Trospium chloride drug products have been described to undergo a negative food effect of more than 80% following ingestion with food. The tablets showed prolonged disintegration times and reduced dissolution rates in viscous media, which could be attributed to changes in the liquid penetration rates. The effect was particularly significant for film-coated tablets relative to uncoated dosage forms. The results show the necessity of considering media viscosity when designing in vitro models of drug release for BCS type III drug formulations.

  13. Saliva versus plasma bioequivalence of rusovastatin in humans: validation of class III drugs of the salivary excretion classification system.

    Science.gov (United States)

    Idkaidek, Nasir; Arafat, Tawfiq

    2015-03-01

    Bioequivalence of rusovastatin in healthy human volunteers was done using saliva and plasma matrices in order to investigate the robustness of using saliva instead of plasma as a surrogate for bioequivalence of class III drugs according to the salivary excretion classification system (SECS). Saliva and plasma samples were collected for 72 h after oral administration of rusovastatin 40 mg to 12 healthy humans. Saliva and plasma pharmacokinetic parameters were calculated by non-compartmental analysis. Analysis of variance, 90 % confidence intervals, and intra-subject and inter-subject variability values of pharmacokinetic parameters were calculated using Kinetica program V5. Human effective intestinal permeability was also calculated by SimCYP program V13. Rusovastatin falls into class III (high permeability/low fraction unbound to plasma proteins) and hence was subjected to salivary excretion. A correlation coefficient of 0.99 between saliva and plasma concentrations, and a saliva/plasma concentration ratio of 0.175 were observed. The 90 % confidence limits of area under the curve (AUClast) and maximum concentration (C max) showed similar trends in both saliva and plasma. On the other hand, inter- and intra-subject variability values in saliva were higher than in plasma, leading to the need for a slightly higher number of subjects to be used in saliva studies. Non-invasive saliva sampling instead of the invasive plasma sampling method can be used as a surrogate for bioequivalence of SECS class III drugs when an adequate sample size is used.

  14. Treatment Approach for Maxillary Hypoplasia in Cleft Patients: Class III Elastics with Skeletal Anchorage (Report of Two Cases)

    Science.gov (United States)

    Jahanbin, Arezoo; Kazemian, Mozhgan; Saeedi-Pouya, Iman; Eslami, Neda; Shafaee, Hooman

    2016-01-01

    Introduction: Treatment of cleft lip and palate patients requires a multidisciplinary plan. These patients usually have a hypoplastic maxilla due to the prior surgical scars. Orthognathic surgery to advance the maxilla in these patients is not very efficient; therefore, orthopedic interventions during an appropriate age seems to be essential. Case Report: In this article, two cleft lip and palate patients have been treated with Class III elastics anchored to the maxillary posterior and mandibular anterior miniplates in order to induce maxillary advancement. Conclusion: Both cases showed a significant improvement in their profiles with minimal dentoalveolar compensations. A counterclockwise rotation of the mandible occurred. PMID:27602343

  15. TGF-{beta}-stimulated aberrant expression of class III {beta}-tubulin via the ERK signaling pathway in cultured retinal pigment epithelial cells

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Eun Jee [Department of Ophthalmology, National Health Insurance Corporation Ilsan Hospital, Gyeonggi-do (Korea, Republic of); Chun, Ji Na; Jung, Sun-Ah [Konyang University Myunggok Medical Research Institute, Kim' s Eye Hospital, Konyang University College of Medicine, Seoul (Korea, Republic of); Cho, Jin Won [Department of Biology, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-749 (Korea, Republic of); Lee, Joon H., E-mail: joonhlee@konyang.ac.kr [Konyang University Myunggok Medical Research Institute, Kim' s Eye Hospital, Konyang University College of Medicine, Seoul (Korea, Republic of)

    2011-11-18

    Highlights: Black-Right-Pointing-Pointer TGF-{beta} induces aberrant expression of {beta}III in RPE cells via the ERK pathway. Black-Right-Pointing-Pointer TGF-{beta} increases O-GlcNAc modification of {beta}III in RPE cells. Black-Right-Pointing-Pointer Mature RPE cells have the capacity to express a neuron-associated gene by TGF-{beta}. -- Abstract: The class III {beta}-tubulin isotype ({beta}{sub III}) is expressed exclusively by neurons within the normal human retina and is not present in normal retinal pigment epithelial (RPE) cells in situ or in the early phase of primary cultures. However, aberrant expression of class III {beta}-tubulin has been observed in passaged RPE cells and RPE cells with dedifferentiated morphology in pathologic epiretinal membranes from idiopathic macular pucker, proliferative vitreoretinopathy (PVR) and proliferative diabetic retinopathy (PDR). Transforming growth factor-{beta} (TGF-{beta}) has been implicated in dedifferentiation of RPE cells and has a critical role in the development of proliferative vitreoretinal diseases. Here, we investigated the potential effects of TGF-{beta} on the aberrant expression of class III {beta}-tubulin and the intracellular signaling pathway mediating these changes. TGF-{beta}-induced aberrant expression and O-linked-{beta}-N-acetylglucosamine (O-GlcNac) modification of class III {beta}-tubulin in cultured RPE cells as determined using Western blotting, RT-PCR and immunocytochemistry. TGF-{beta} also stimulated phosphorylation of ERK. TGF-{beta}-induced aberrant expression of class III {beta}-tubulin was significantly reduced by pretreatment with U0126, an inhibitor of ERK phosphorylation. Our findings indicate that TGF-{beta} stimulated aberrant expression of class III {beta}-tubulin via activation of the ERK signaling pathway. These data demonstrate that mature RPE cells have the capacity to express a neuron-associated gene in response to TGF-{beta} stimulation and provide useful information

  16. Invertebrate and vertebrate class III myosins interact with MORN repeat-containing adaptor proteins.

    Directory of Open Access Journals (Sweden)

    Kirk L Mecklenburg

    Full Text Available In Drosophila photoreceptors, the NINAC-encoded myosin III is found in a complex with a small, MORN-repeat containing, protein Retinophilin (RTP. Expression of these two proteins in other cell types showed NINAC myosin III behavior is altered by RTP. NINAC deletion constructs were used to map the RTP binding site within the proximal tail domain of NINAC. In vertebrates, the RTP ortholog is MORN4. Co-precipitation experiments demonstrated that human MORN4 binds to human myosin IIIA (MYO3A. In COS7 cells, MORN4 and MYO3A, but not MORN4 and MYO3B, co-localize to actin rich filopodia extensions. Deletion analysis mapped the MORN4 binding to the proximal region of the MYO3A tail domain. MYO3A dependent MORN4 tip localization suggests that MYO3A functions as a motor that transports MORN4 to the filopodia tips and MORN4 may enhance MYO3A tip localization by tethering it to the plasma membrane at the protrusion tips. These results establish conserved features of the RTP/MORN4 family: they bind within the tail domain of myosin IIIs to control their behavior.

  17. Orthodontic decompensation in skeletal Class III malocclusion: redefining the amount of movement assessed by Cone-Beam Computed Tomography

    Directory of Open Access Journals (Sweden)

    José Antonio Zuega Cappellozza

    2015-10-01

    Full Text Available Introduction:Cone-Beam Computed Tomography (CBCT is essential for tridimensional planning of orthognathic surgery, as it allows visualization and evaluation of bone structures and mineralized tissues. Tomographic slices allow evaluation of tooth inclination and individualization of movement performed during preoperative decompensation. The aim of this paper was to assess maxillary and mandibular incisors inclination pre and post orthodontic decompensation in skeletal Class III malocclusion.Methods:The study was conducted on six individuals with skeletal Class III malocclusion, surgically treated, who had Cone-Beam Computed Tomographic scans obtained before and after orthodontic decompensation. On multiplanar reconstruction view, tomographic slices (axial, coronal and sagittal were obtained on the long axis of each incisor. The sagittal slice was used for measurement taking, whereas the references used to assess tooth inclination were the long axis of maxillary teeth in relation to the palatal plane and the long axis of mandibular teeth in relation to the mandibular plane.Results:There was significant variation in the inclination of incisors before and after orthodontic decompensation. This change was of greater magnitude in the mandibular arch, evidencing that natural compensation is more effective in this arch, thereby requiring more intensive decompensation.Conclusion:When routinely performed, the protocols of decompensation treatment in surgical individuals often result in intensive movements, which should be reevaluated, since the extent of movement predisposes to reduction in bone attachment levels and root length.

  18. Orthodontic and dentofacial orthopedic management of juvenile idiopathic arthritis: a systematic review of the literature.

    Science.gov (United States)

    von Bremen, J; Ruf, S

    2011-08-01

    To systematically review the literature published on orthodontic treatment principles in patients with juvenile idiopathic arthritis (JIA). Several electronic databases (PubMed, Medpilot, Web of Science, and DIMDI) and orthodontic and rheumatologic literature were systematically searched for studies published until May 2010. The articles were rated by two independent reviewers and included after three selection steps (title-abstract-full text). Articles had to be studies performed on ≥ 5 patients with a disease onset before the age of 16. The selection process resulted in the inclusion of three publications on dentofacial orthopedics and six on combined surgical orthodontic therapy. The three studies on dentofacial orthopedics aimed to improve the mandibular retrusion by means of removable functional appliances (activator). Whereas these orthodontic approaches comprised relatively large and homogeneous patient samples (14, 22, and 72 subjects, aged 6-16), the surgical studies were basically case series with a large age span of the patients (5-12 subjects, aged 10-44). In these surgical treatment approaches, orthodontics was limited to pre-surgical leveling and post-surgical finishing, while the skeletal discrepancy was treated surgically by a variety of techniques (costochondral grafts, bilateral sagittal spilt osteotomy, Le Fort I, and genioplasty). The treatment goals of both approaches were improvement of esthetics and function and/or pain reduction, and both approaches showed satisfactory results. Because of the heterogeneity of the subject material and the low level of evidence of the papers, it is difficult to draw any conclusions on the orthodontic/dentofacial orthopedic management of JIA. It appears as if removable functional appliances may be beneficial in adolescent patients with JIA. PMID:21771266

  19. 78 FR 20268 - Effective Date of Requirement for Premarket Approval for Three Class III Preamendments Devices...

    Science.gov (United States)

    2013-04-04

    ... preamendments devices: Sorbent hemoperfusion devices for the treatment of hepatic coma and metabolic... hemoperfusion devices for the treatment of hepatic coma and metabolic disturbances; cranial electrotherapy... reclassified into class I or II or FDA issues an order finding the device to be substantially equivalent,...

  20. Cardiac resynchronization induces major structural and functional reverse remodeling in patients with New York Heart Association class I/II heart failure

    DEFF Research Database (Denmark)

    St John Sutton, Martin; Ghio, Stefano; Plappert, Ted;

    2009-01-01

    BACKGROUND: Cardiac resynchronization therapy (CRT) improves LV structure, function, and clinical outcomes in New York Heart Association class III/IV heart failure with prolonged QRS. It is not known whether patients with New York Heart Association class I/II systolic heart failure exhibit left...... ventricular (LV) reverse remodeling with CRT or whether reverse remodeling is modified by the cause of heart failure. METHODS AND RESULTS: Six hundred ten patients with New York Heart Association class I/II heart failure, QRS duration > or =120 ms, LV end-diastolic dimension > or =55 mm, and LV ejection...... reduction in LV end-diastolic and end-systolic volume indexes and a 3-fold greater increase in LV ejection fraction in patients with nonischemic causes of heart failure. CONCLUSIONS: CRT in patients with New York Heart Association I/II resulted in major structural and functional reverse remodeling at 1 year...

  1. Digital Smile Design Meets the Dento-Facial Analyzer: Optimizing Esthetics While Preserving Tooth Structure.

    Science.gov (United States)

    Tak On, Tse; Kois, John C

    2016-01-01

    This case of an adult male patient with missing maxillary lateral incisors who was unhappy with his smile focuses on implementation of the digital smile design (DSD) concept. Combined with the use of a dento-facial analyzer, DSD, which employs a series of extraoral photographs, allowed the clinician to preoperatively plan different approaches to the treatment and visualize the outcome of each one, as well as to effectively communicate critical tooth position references to the laboratory technician and the patient. The additive approach used in this case minimized tooth preparation while creating an esthetic smile.

  2. Effectiveness of circumoral muscle exercises in the developing dentofacial morphology in adenotonsillectomized children: An ultrasonographic evaluation

    Directory of Open Access Journals (Sweden)

    Das U

    2009-06-01

    Full Text Available Alterations in the functions of the facial muscle can establish changes in facial skeleton and in the development of occlusion. The effect of mouth breathing on the facial morphology is probably greatest during the growth period. Removal of nasal obstruction, adenoids, and tonsils have not given beneficial results in the reversion of the habit unless intercepted with various muscle exercises. Hence, this study was conducted to ultrasonographically evaluate the effectiveness of circumoral muscle exercises in the developing dentofacial morphology in adenotonsillectomized children.

  3. Estudo comparativo cefalométrico dos padrões dentofaciais de indivíduos portadores de oclusão normal e de más oclusões de Angle Comparative cephalometric study of dentofacial patterns of individuals with normal occlusion and Angle malocclusions

    Directory of Open Access Journals (Sweden)

    Julio César Mota Pereira

    2011-10-01

    Full Text Available OBJETIVO: avaliar os padrões dentofaciais de pacientes portadores de oclusão normal e más oclusões de Angle quanto a possíveis diferenças entre as grandezas estudadas, em relação ao sexo, dentro de cada grupo e entre os grupos. MÉTODOS: a amostra constou de 200 telerradiografias cefalométricas laterais obtidas de jovens brasileiros, de ambos os sexos, na faixa etária de 11 anos e 2 meses a 19 anos e 10 meses, apresentando dentição permanente. O material foi dividido, quanto ao tipo de oclusão, em cinco grupos: um de pacientes portadores de oclusão normal, e quatro de pacientes portadores de más oclusões de Angle, sendo cada grupo dividido igualmente quanto ao sexo. Foram avaliadas grandezas cefalométricas angulares e lineares. RESULTADOS: na grande maioria das grandezas, os sexos masculino e feminino não diferiram; entre os grupos, a posição da maxila não mostrou diferença significativa, o retrognatismo mandibular foi marcante nos grupos de Classe II divisões 1ª e 2ª e foram observados alguns desequilíbrios verticais com diferenças significativas; o padrão foi hipodivergente para os grupos de oclusão normal e Classe II, divisão 2ª, e neutro para os grupos de Classe I; Classe II, divisão 1ª; e Classe III; a compensação dentoalveolar foi evidente nos grupos de Classe III e de Classe II, divisão 2ª; o grupo de oclusão normal apresentou perfil mais convexo que os padrões americanos. CONCLUSÃO: foi possível configurar, de forma geral, algumas características da morfologia facial para alguns tipos de más oclusões. Entretanto, existe a necessidade de avaliar a face individualmente, pois algumas características permeiam entre os diferentes tipos de oclusão.OBJECTIVE: To determine the dentofacial patterns in patients presenting normal occlusion and Angle malocclusions, evaluating the possible differences in the studied measurements, considering the gender, the differences within each group and the

  4. Intervenção ortocirúrgica em paciente adolescente com acentuada displasia esquelética de Classe III Orthodontic-surgical treatment in youthful patient with severe skeletal Class III malocclusion

    Directory of Open Access Journals (Sweden)

    Andressa Otranto de Britto Teixeira

    2007-10-01

    Full Text Available INTRODUÇÃO: a má oclusão de Classe III é caracterizada por uma discrepância esquelética ântero-posterior, podendo ou não estar acompanhada de alterações verticais, mas comumente apresenta alterações transversais associadas. O aspecto facial fica comprometido nesses pacientes, sendo esse um dos fatores que os motivam a procurar o tratamento ortodôntico. Quando o paciente encontra-se na faixa de 8 a 10 anos de idade, uma abordagem precoce é indicada. Quando o paciente é adulto e o crescimento já cessou, o tratamento vai ser decidido entre a camuflagem ortodôntica e os procedimentos ortocirúrgicos clássicos. O problema quanto à decisão terapêutica está no paciente adolescente, com acentuadas Classes III esqueléticas, quando os procedimentos interceptativos não mais surtirão o efeito desejado e as alterações faciais são muito significativas. Ainda haverá crescimento e muitas vezes há comprometimento psicossocial ou funcional. OBJETIVO: propor uma abordagem cirúrgica precoce como alternativa de tratamento para esses pacientes, mesmo que uma segunda cirurgia seja necessária após o término do crescimento. DISCUSSÃO: para se propor essa terapia, vários critérios devem ser observados para que realmente o paciente tenha benefícios com esta intervenção precoce, como pouca discrepância intra-arco e possibilidade de preparo ortodôntico pré-cirúrgico rápido. CONCLUSÃO: deve-se ter ciência que um segundo tratamento ortocirúrgico provavelmente se fará necessário após o término do crescimento e que esse tipo de tratamento não deve ser empregado como rotina.INTRODUCTION: Class III malocclusion is characterized by an anterior-posterior skeletal discrepancy that may or may not be combined with vertical alterations, but it commonly presents transverse disharmony associated. The facial aspect is affected in these patients, which is one of the factors that motivate them to look for orthodontic treatment. For young

  5. Crescimento da base craniana nos diferentes tipos faciais nos relacionamentos maxilomandibulares ortopédicos de Classe I, II e III: parte 3 (Crescimento médio de CF-Po Cranial base growth in different facial types in Class I, II and III orthopedic maxillomandibular relationship: part 3 (Mean growth of CF-Po

    Directory of Open Access Journals (Sweden)

    Lucelma Vilela Pieri

    2007-06-01

    Full Text Available OBJETIVO: este estudo retrospectivo avaliou o crescimento médio de CF-Po nos diferentes tipos faciais nos relacionamentos maxilomandibulares ortopédicos de Classe I, II e III. METODOLOGIA: uma amostra aleatória de 300 pacientes brasileiros leucodermas (131 do gênero masculino, 169 do gênero feminino, com idade média inicial de 10 anos e 2 meses (dentadura mista e final de 14 anos e 8 meses (segundos molares em oclusão e tempo médio de observação de 4 anos e 5 meses, foi selecionada em uma clínica particular, em São Paulo, Brasil. Havia 118 pacientes Classe I, 151 Classe II e 31 Classe III. Todas as 600 radiografias cefalométricas laterais foram obtidas no mesmo aparelho de raios-x. As análises de Ricketts e Schwarz modificadas por Faltin foram usadas. A medida linear CF-Po foi feita manualmente pelo mesmo examinador em T1 e T2. Os relacionamentos foram estudados juntos e separadamente, considerando tipo facial e gênero. A análise de variância de ANOVA foi aplicada. RESULTADOS E CONCLUSÕES: o tipo facial retrovertido mostrou-se significativamente desfavorável à correção de Classe III mandibular no gênero masculino; com tendência desfavorável à Classe II mandibular e crescimento ântero-posterior favorável na Classe I. O neutrovertido mostrou-se significativamente favorável à correção de Classe III mandibular em ambos os gêneros; com tendência favorável à correção de Classe II mandibular e ao crescimento ântero-posterior na Classe I. O provertido mostrou-se significativamente desfavorável à correção de Classe III em ambos os gêneros e favorável na Classe II mandibular e com tendência favorável de crescimento ântero-posterior na Classe I, principalmente no gênero masculino.AIM: This retrospective study assessed the cranial base growth and development in different facial types in Class I, II and III orthopedic maxillomandibular relationship. METHODS: A random sample of 300 Brazilian Caucasian patients

  6. Oral Rehabilitation With Orthognathic Surgery After Dental Implant Placement for Class III Malocclusion With Skeletal Asymmetry and Posterior Bite Collapse.

    Science.gov (United States)

    Ohba, Seigo; Nakatani, Yuya; Kawasaki, Takako; Tajima, Nobutaka; Tobita, Takayoshi; Yoshida, Noriaki; Sawase, Takashi; Asahina, Izumi

    2015-08-01

    Increasing numbers of older patients are seeking orthognathic surgery to treat jaw deformity. However, orthodontic and orthognathic surgical treatment is difficult in cases without occlusal vertical stop. A 55-year-old man presented with Class III malocclusion and mandibular protrusion including esthetic problems and posterior bite collapse. He underwent dental implant treatment to reconstruct an occlusal vertical stop before orthognathic surgery. His occlusal function and esthetic problems improved after surgery, and his skeletal and occlusal stability has been maintained for 6 years. Dental implant placement at appropriate positions could help to determine the position of the proximal segment at orthognathic surgery and could shorten the time required to restore esthetic and occlusal function. This case demonstrates how skeletal and dental stability can be maintained long after surgery in a patient with jaw deformity and posterior bite collapse. PMID:26035376

  7. Novel three-dimensional position analysis of the mandibular foramen in patients with skeletal class III mandibular prognathism

    Science.gov (United States)

    Kim, Yeon-Ho; Won, Yu-Jin; Kim, Moon-Key

    2016-01-01

    Purpose To analyze the relative position of the mandibular foramina (MnFs) in patients diagnosed with skeletal class III malocclusion. Materials and Methods Computed tomography (CT) images were collected from 85 patients. The vertical lengths of each anatomic point from the five horizontal planes passing through the MnF were measured at the coronoid process, sigmoid notch, condyle, and the gonion. The distance from the anterior ramus point to the posterior ramus point on the five horizontal planes was designated the anteroposterior horizontal distance of the ramus for each plane. The perpendicular distance from each anterior ramus point to each vertical plane through the MnF was designated the horizontal distance from the anterior ramus to the MnF. The horizontal and vertical positions were examined by regression analysis. Results Regression analysis showed the heights of the coronoid process, sigmoid notch, and condyle for the five horizontal planes were significantly related to the height of the MnF, with the highest significance associated with the MnF-mandibular plane (coefficients of determination (R2): 0.424, 0.597, and 0.604, respectively). The horizontal anteroposterior length of the ramus and the distance from the anterior ramus point to the MnF were significant by regression analysis. Conclusion The relative position of the MnF was significantly related to the vertical heights of the sigmoid notch, coronoid process, and condyle as well as to the horizontal anteroposterior length of the ascending ramus. These findings should be clinically useful for patients with skeletal class III mandibular prognathism. PMID:27358814

  8. Social class, political power, and the state: their implications in medicine--part III.

    Science.gov (United States)

    Navarro, V

    1977-01-01

    This is the third part of an article on the distribution of power and the nature of the state in Western industrialized societies and their implications in medicine. Parts I and II were published in the preceding issue of this Journal. Part I presented a critique of contemporary theories of the Western system of power; discussed the countervailing pluralist and power of elite theories, as well as those of bureaucratic and professional control; and concluded with an examination of the Marxist theories of economic determinism, structural determinism, and corporate statism. Part II presented a Marxist theory of the role, nature, and characteristics of state intervention. Part III focuses on the mode of that intervention and the reasons for its growth, with an added analysis of the attributes of state intervention in the health sector, and of the dialectical relationship between its growth and the current fiscal crisis of the state. In all three parts, the focus is on Western European countries and on North America, with many examples and categories from the area of medicine. PMID:870557

  9. Comparative study of design of piping supports class 1, 2 and 3 considering german code KTA and ASME III - NF

    International Nuclear Information System (INIS)

    The objective of this paper is developing a comparative study of the design criteria for class 1, 2, 3 piping supports considering the American Code ASME Section III - NF and the German Code KTA 3205.1 to the Primary Circuit, KTA 3205.2 to the others systems and KTA 3205.3 series-production standards supports of a PWR nuclear power plant. An additional purpose of the paper is a general analysis of the main design concepts of the American Code ASME Boiler and Pressure Vessel Code, Section III, Division 1 and German Nuclear Design Code KTA that was performed in order to aid the comparative study proposed. The relevance of this study is to show the differences between codes ASME and KTA since they were applied in the design of the Nuclear Power Plants Angra 1 and Angra 2, and to the design of Angra 3, which is at the moment under construction. It is also considered their use in the design of nuclear installations such as RMB - Reator MultiProposito Brasileiro and LABGENE - Laboratorio de Geracao Nucleoeletrica. (author)

  10. 安氏Ⅲ类骨性Ⅲ类与安氏I类错牙合畸形舌体形态位置及舌骨位置的比较研究%Comparative Study between the tongue shape and hyoid bone position in Angle Class III and Skeletal Class III Malocclusion and Those in Angle Class I Malocclusion

    Institute of Scientific and Technical Information of China (English)

    袁小平; 朗么磋; 王昊

    2014-01-01

    Objective To compare the tongue shape and hyoid bone position in Angle class III and skeletal class III malocclusion with those in Angle class I malocclusion. Methods 46 cases were enrolled, including 26 cases of Angle class III and skeletal III maloc-clusion and 20 cases of Angle class I malocclusion;the dorsum of tongues were coated with barium sulfate and lateral X-ray of the head was taken;17 spots on the tongue and hyoid bone were selected and traced, and 13 measured values were analyzed. Results The tongue tips of the patients of Angle class III and skeletal class III malocclusion were positioned more anterior(O-T1), the hyoid more posterior (O-T7)and the tongue middle more inferior(O-T2,T3)compared with the patients of Angle class I malocclusion, the difference was of statistical significance (P<0.05); The tongues of patients of Angle class III and skeletal class III malocclusion were longer than those of patients of Angle class I malocclusion, the difference was of obvious statistical significance (P<0.01);The hyoid bone of patients of An-gle class III and skeletal class III malocclusion was positioned more anterior inferiorly than that of patients of Angle class I malocclu-sion, the difference was of obvious statistical significance (P<0.01, P<0.01). Conclusions The tongue shape and hyoid bone position of patients of Angle class III and skeletal class III malocclusion are of certain difference from those of patients of Angle class I malocclu-sion.%目的:比较安氏Ⅲ类骨性Ⅲ类与安氏I类错牙合畸形舌体形态位置及舌骨位置。方法对46例患者(实验组安氏Ⅲ类骨性Ⅲ类26例,对照组安氏I类20例)拍摄头侧位X光片并在舌背涂抹硫酸钡糊剂,选择舌体及舌骨的17个点进行描记,对13个测量值进行分析。结果(1)安氏Ⅲ类骨性Ⅲ类错牙合畸形患者比安氏I类错牙合畸形患者舌尖位置偏前(O-T1)、舌根位置偏后(O-T7)、舌体中断偏低(O-T2,T3

  11. Impact of Dentofacial Deformity on Quality of Life: Age and Gender Differences Evaluated Through OQLQ, OHIP and SF36

    Directory of Open Access Journals (Sweden)

    Marcelo Carlos Bortoluzzi

    2015-09-01

    Full Text Available Objectives: The aim of this study was to verify the impact of dentofacial deformity on quality of life and explore gender and age differences. Material and Methods: The impact of dentofacial deformity (DD on quality of life was evaluated through questionnaires; Short Form Health Survey (SF36, Oral Health Impact Profile Questionnaire (OHIP, Orthognathic Quality of Life Questionnaire (OQLQ and a single question answered by a Visual Analogue Scale. Results: Significant differences between male and female patients were observed in domains of OQLQ (oral function, P = 0.006; awareness of facial deformity, P = 0.018; and facial aesthetics, P < 0.001 and OHIP (physical pain, P = 0.006; psychological discomfort, P = 0.007; psychological disability, P = 0.006; and handicap, P = 0.01. Conclusions: The impact of dentofacial deformity was more pronounced in female Brazilian population. Age of patients with dentofacial deformity produced impacts over quality of life in different ways and according to the applied questionnaire and the interaction between age and gender may also produce different impacts in patients with dentofacial deformity. The domains of Orthognathic Quality of Life Questionnaire, Oral Health Impact Profile Questionnaire and Short Form Health Survey showed unaccepted distances in the pattern of answer rising doubts of their ability to assess quality of life as a generic and broad concept. There is a necessity to create a single quality of life instrument capable to measure impacts with sensitivity and specificity and from a generic concept to condition-specific health problem.

  12. 40 CFR Figure C-3 to Subpart C of... - Illustration of the Slope and Intercept Limits for Class II and Class III PM10−2.5 Candidate...

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 5 2010-07-01 2010-07-01 false Illustration of the Slope and Intercept Limits for Class II and Class III PM10â2.5 Candidate Equivalent Methods C Figure C-3 to Subpart C of Part... Candidate Methods and Reference Methods Pt. 53, Subpt. C, Fig. C-3 Figure C-3 to Subpart C of Part...

  13. ELECTROPHARMACOLOGIC EFFECTS AND PHARMACOKINETICS OF ALMOKALANT, A NEW CLASS-III ANTIARRHYTHMIC, IN PATIENTS WITH HEALED OR HEALING MYOCARDIAL INFARCTS AND COMPLEX VENTRICULAR ARRHYTHMIAS

    NARCIS (Netherlands)

    WIESFELD, ACP; CRIJNS, HJGM; TOBE, TJM; ALMGREN, O; BERGSTRAND, RH; ABERG, J; HAAKSMA, J; LIE, KI

    1992-01-01

    The electropharmacologic effects and pharmacokinetics of almokalant, a new class III antiarrhythmic, were investigated in a randomized, placebo-controlled, double-blind study, and efficacy was evaluated. Ten post-myocardial infarction patients with complex ventricular arrhythmias were included and r

  14. Identification of a system required for the functional surface localization of sugar binding proteins with class III signal peptides in Sulfolobus solfataricus

    NARCIS (Netherlands)

    Zolghadr, Behnam; Weber, Stefan; Szabo, Zalan; Driessen, Arnold J. M.; Albers, Sonja-Verena

    2007-01-01

    The hyperthermophilic archaeon Sulfolobus solfataricus contains an unusual large number of sugar binding proteins that are synthesized as precursors with a class III signal peptide. Such signal peptides are commonly used to direct archaeal flagellin subunits or bacterial (pseudo)pilins into extracel

  15. [Molecular evidences of non-ADH pathway in alcohol metabolism and Class III alcohol dehydrogenase (ADH3)].

    Science.gov (United States)

    Haseba, Takeshi

    2014-06-01

    Class I alcohol dehydrogenase (ADH1), a key enzyme of alcohol metabolism, contributes around 70% to the systemic alcohol metabolism and also to the acceleration of the metabolism due to chronic alcohol consumption by increasing its liver content, if the liver damage or disease is not apparent. However, the contribution of ADH1 to alcohol metabolism decreases in case of acute alcohol poisoning or chronic alcohol consumption inducing liver damage or disease. On the contrary, non-ADH pathway, which is independent of ADH1, increases the contribution to alcohol metabolism in these cases, by complementing the reduced role of ADH1. The molecular substantiality of non-ADH pathway has been still unknown in spite of the long and hot controversy between two candidates of microsomal ethanol oxidizing system (MEOS) and catalase. This research history suggests the existence of other candidates. Among ADH isozymes, Class III (ADH3) has the highest Km for ethanol and the highest resistance to pyrazole reagents of specific ADH inhibitors. This ADH3 was demonstrated to increase the contribution to alcohol metabolism in vivo dose-dependently, therefore, is a potent candidate of non-ADH pathway. Moreover, ADH3 is considered to increase the contribution to alcohol metabolism in case of alcoholic liver diseases, because the enzyme content increases in damaged tissues with increased hydrophobicity or the activity of the liver correlates with the accumulated alcohol consumptions of patients with alcoholic liver diseases. Such adaptation of ADH3 to alcohol metabolism in these pathological conditions makes patients possible to keep drinking a lot in spite of decrease of ADH1 activity and develops alcoholism seriously.

  16. Abundant class III acidic chitinase homologue in tamarind (Tamarindus indica) seed serves as the major storage protein.

    Science.gov (United States)

    Rao, Devavratha H; Gowda, Lalitha R

    2008-03-26

    The phyla Leguminosae contains protease inhibitors, lectins, chitinases, and glycohydrolases as major defense proteins in their seeds. Electrophoretic analysis of the seed proteins of tamarind ( Tamarindus indica L.), an agri-waste material, indicated the unusual presence of two major proteins comparable to overexpression of recombinant proteins. These proteins were identified by amino-terminal analysis to be (1) Kunitz-type trypsin inhibitor and (2) class III endochitinase (34000 Da). These two proteins were purified to apparent homogeneity by a single-step chitin bead affinity chromatography and characterized. The Kunitz inhibitor was specific toward inhibiting trypsin with a stoichiometry of 1:1. The 33000 +/- 1000 Da protein, accounting for >50% of the total seed protein, is an acidic glycoprotein exhibiting a very low endotype hydrolytic activity toward chitin derivatives. SDS-PAGE followed by densitometry of tamarind seed germination indicates the disappearance of the chitinase with the concomitant appearance of a cysteine endopeptidase. On the basis of its abundance, accumulation without any pathogenesis-related stimulus, temporal regulation, amino acid composition, and very low enzyme activity, this 34000 Da protein designated "tamarinin" physiologically serves as the major storage protein.

  17. Spitzer IRS Observations of Class I/II Objects in Taurus: Composition, Temperature and Thermal History of the Circumstellar Ices

    CERN Document Server

    Zasowski, G; Watson, Dan M; Furlan, E; Bohac, C J; Hull, C; Green, J D

    2007-01-01

    We present observations of Taurus-Auriga Class I/II protostars obtained with the Spitzer InfraRed Spectrograph. Detailed spectral fits to the 6 and 15 micron features are made, using publicly-available laboratory data, to constrain the molecular composition, abundances, and levels of thermal processing along the lines of sight. We provide an inventory of the molecular environments observed, which have an average composition dominated by water ice with ~12% CO_2 (abundance relative to H_2O), >~2-9% CH_3OH, <~14% NH_3, ~4% CH_4, ~2% H_2CO, ~0.6% HCOOH, and ~0.5% SO_2. We find CO_2/H_2O ratios nearly equivalent to those observed in cold clouds and lines of sight toward the galactic center. The unidentified 6.8 micron profile shapes vary from source to source, and it is shown to be likely that even combinations of the most common candidates (NH_4+ and CH_3OH) are inadequate to explain the feature fully. We discuss correlations among SED spectral indices, abundance ratios, and thermally-processed ice fractions ...

  18. More on fatigue verification of Class 1 nuclear power piping according to ASME BPV III NB-3600

    International Nuclear Information System (INIS)

    In this paper, fatigue verification of Class 1 nuclear power piping according to ASME Boiler and Pressure Vessel Code, Section III, NB-3600, and relevant issues that are often discussed in connection to the power uprate of several Swedish BWR reactors in recent years, are dealt with. Key parameters involved in the fatigue verification, i.e. the alternating stress intensity Salt, the penalty factor Ke and the cumulative damage factor U, and relevant computational procedures applicable for the assessment of low-cycle fatigue failure using strain-controlled data, are particularly addressed. A so-called simplified elastic-plastic discontinuity analysis for alternative verification when basic fatigue requirements found unsatisfactory, and the procedures provided in NB-3600 for evaluating the alternating stress intensity Salt, are reviewed in detail. Our emphasis is placed on other procedures alternative to the simplified elastic-plastic discontinuity analysis. A more in-depth discussion is given to an alternative suggested earlier by the authors using nonlinear finite element analyses. This paper is a continuation of our work presented in ICONE16/17/18, which attempted to categorize design rules in the code into linear design rules and non-linear design rules and to clarify corresponding design requirements and finite element analyses, in particular, those non-linear ones. (author)

  19. PCSK1 rs6232 Is Associated with Childhood and Adult Class III Obesity in the Mexican Population

    Science.gov (United States)

    Villalobos-Comparán, Marisela; Villamil-Ramírez, Hugo; Villarreal-Molina, Teresa; Larrieta-Carrasco, Elena; León-Mimila, Paola; Romero-Hidalgo, Sandra; Jacobo-Albavera, Leonor; Liceaga-Fuentes, Adriana E.; Campos-Pérez, Francisco J.; López-Contreras, Blanca E.; Tusié-Luna, Teresa; del Río-Navarro, Blanca E.; Aguilar-Salinas, Carlos A.; Canizales-Quinteros, Samuel

    2012-01-01

    Background Common variants rs6232 and rs6235 in the PCSK1 gene have been associated with obesity in European populations. We aimed to evaluate the contribution of these variants to obesity and related traits in Mexican children and adults. Methodology/Principal Findings Rs6232 and rs6235 were genotyped in 2382 individuals, 1206 children and 1176 adults. Minor allele frequencies were 0.78% for rs6232 and 19.99% for rs6235. Rs6232 was significantly associated with childhood obesity and adult class III obesity (OR = 3.01 95%CI 1.64–5.53; P = 4×10−4 in the combined analysis). In addition, this SNP was significantly associated with lower fasting glucose levels (P = 0.01) and with increased insulin levels and HOMA-B (P = 0.05 and 0.01, respectively) only in non-obese children. In contrast, rs6235 showed no significant association with obesity or with glucose homeostasis parameters in any group. Conclusion/Significance Although rs6232 is rare in the Mexican population, it should be considered as an important risk factor for extreme forms of obesity. PMID:22737226

  20. Pseudomonas aeruginosa Exhibits Deficient Biofilm Formation in the Absence of Class II and III Ribonucleotide Reductases Due to Hindered Anaerobic Growth.

    Science.gov (United States)

    Crespo, Anna; Pedraz, Lucas; Astola, Josep; Torrents, Eduard

    2016-01-01

    Chronic lung infections by the ubiquitous and extremely adaptable opportunistic pathogen Pseudomonas aeruginosa correlate with the formation of a biofilm, where bacteria grow in association with an extracellular matrix and display a wide range of changes in gene expression and metabolism. This leads to increased resistance to physical stress and antibiotic therapies, while enhancing cell-to-cell communication. Oxygen diffusion through the complex biofilm structure generates an oxygen concentration gradient, leading to the appearance of anaerobic microenvironments. Ribonucleotide reductases (RNRs) are a family of highly sophisticated enzymes responsible for the synthesis of the deoxyribonucleotides, and they constitute the only de novo pathway for the formation of the building blocks needed for DNA synthesis and repair. P. aeruginosa is one of the few bacteria encoding all three known RNR classes (Ia, II, and III). Class Ia RNRs are oxygen dependent, class II are oxygen independent, and class III are oxygen sensitive. A tight control of RNR activity is essential for anaerobic growth and therefore for biofilm development. In this work we explored the role of the different RNR classes in biofilm formation under aerobic and anaerobic initial conditions and using static and continuous-flow biofilm models. We demonstrated the importance of class II and III RNR for proper cell division in biofilm development and maturation. We also determined that these classes are transcriptionally induced during biofilm formation and under anaerobic conditions. The molecular mechanism of their anaerobic regulation was also studied, finding that the Anr/Dnr system is responsible for class II RNR induction. These data can be integrated with previous knowledge about biofilms in a model where these structures are understood as a set of layers determined by oxygen concentration and contain cells with different RNR expression profiles, bringing us a step closer to the understanding of this

  1. Pseudomonas aeruginosa exhibits deficient biofilm formation in the absence of class II and III ribonucleotide reductases due to hindered anaerobic growth.

    Directory of Open Access Journals (Sweden)

    Anna eCrespo

    2016-05-01

    Full Text Available Chronic lung infections by the ubiquitous and extremely adaptable opportunistic pathogen Pseudomonas aeruginosa correlate with the formation of a biofilm, where bacteria grow in association with an extracellular matrix and display a wide range of changes in gene expression and metabolism. This leads to increased resistance to physical stress and antibiotic therapies, while enhancing cell-to-cell communication. Oxygen diffusion through the complex biofilm structure generates an oxygen concentration gradient, leading to the appearance of anaerobic microenvironments.Ribonucleotide reductases (RNRs are a family of highly sophisticated enzymes responsible for the synthesis of the deoxyribonucleotides, and they constitute the only de novo pathway for the formation of the building blocks needed for DNA synthesis and repair. P. aeruginosa is one of the few bacteria encoding all three known RNR classes (Ia, II and III. Class Ia RNRs are oxygen dependent, class II are oxygen independent, and class III are oxygen sensitive. A tight control of RNR activity is essential for anaerobic growth and therefore for biofilm development.In this work we explored the role of the different RNR classes in biofilm formation under aerobic and anaerobic initial conditions and using static and continuous-flow biofilm models. We demonstrated the importance of class II and III RNR for proper cell division in biofilm development and maturation. We also determined that these classes are transcriptionally induced during biofilm formation and under anaerobic conditions. The molecular mechanism of their anaerobic regulation was also studied, finding that the Anr/Dnr system is responsible for class II RNR induction. These data can be integrated with previous knowledge about biofilms in a model where these structures are understood as a set of layers determined by oxygen concentration and contain cells with different RNR expression profiles, bringing us a step closer to the

  2. Molecular cloning of class III chitinase gene from Avicennia marina and its expression analysis in response to cadmium and lead stress.

    Science.gov (United States)

    Wang, Li-Ying; Wang, You-Shao; Zhang, Jing-Ping; Gu, Ji-Dong

    2015-10-01

    Mangrove species have high tolerance to heavy metal pollution. Chitinases have been widely reported as defense proteins in response to heavy metal stress in terrestrial plants. In this study, a full-length cDNA sequence encoding an acidic and basic class III chitinase (AmCHI III) was cloned by using RT-PCR and RACE methods in Avicennia marina. AmCHI III mRNA expression in leaf of A. marina were investigated under Cd, Pb stresses on using real-time quantitative PCR. The deduced AmCHI III protein consists of 302 amino acids, including a signal putative peptide region, and a catalytic domain. Homology modeling of the catalytic domain revealed a typical molecular structure of class III plant chitinases. Results further demonstrated that the regulation of AmCHI III mRNA expression in leaves was strongly dependent on Cd, Pb stresses. AmCHI III mRNA expressions were significantly increased in response to Cd, Pb, and peaked at 7 days Cd-exposure, 7 days Pb-exposure, respectively. AmCHI III mRNA expression exhibited more sensitive to Pb stress than Cd stress. This work was the first time cloing chitinase from A. marina, and it brought evidence on chitinase gene involving in heavy metals (Cd(2+) and Pb(2+)) resistance or detoxification in plants. Further studies including the promoter and upstream regulation, gene over-expression and the response of mangrove chitinases to other stresses will shed more light on the role of chitinase in mangrove plants. PMID:26044930

  3. The influence of children's dentofacial appearance on their social attractiveness as judged by peers and lay adults.

    Science.gov (United States)

    Shaw, W C

    1981-04-01

    The purpose of this study was to determine whether the social attractiveness of a child would be influenced by his or her dentofacial appearance. Black and white photographs of an attractive boy and girl and an unattractive boy and girl were obtained and modified so that, for each face, five different photographic versions were available. In each version, the child's face was standardized except that a different dentofacial arrangement was demonstrated. These were normal incisors, prominent incisors, a missing lateral incisor, severely crowded incisors, and unilateral cleft lip. Each photograph was viewed by a different group of forty-two children and forty-two adults, equally divided as to sex. Their impressions of the depicted child's social attractiveness were recorded on visual analogue scales. The experimental procedure was such that the effect and interaction of different levels of facial attractiveness, different dentofacial arrangements, sex of the photographed child, and sex of the judge could be analyzed. The hypothesis that children with a normal dental appearance would be judged to be better looking, more desirable as friends, more intelligent, and less likely to behave aggressively was upheld. PMID:6939333

  4. Combined Orthodontic and Surgical Approach in the Correction of a Class III Skeletal Malocclusion with Mandibular Prognathism and Vertical Maxillary Excess Using Bimaxillary Osteotomy

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    George Jose Cherackal

    2013-01-01

    Full Text Available For patients whose orthodontic problems are so severe that neither growth modification nor camouflage offers a solution, surgery to realign the jaws or reposition dentoalveolar segments is the only possible treatment. Surgery is not a substitute for orthodontics in these patients. Instead, it must be properly coordinated with orthodontics and other dental treatments to achieve good overall results. Dramatic progress in recent years has made it possible for combined surgical orthodontic treatment to be carried out successfully for patients with a severe dentofacial problem of any type. This case report provides an overview of the current treatment methodology in managing a combination of asymmetrical mandibular prognathism and vertical maxillary excess.

  5. Class III β-tubulin is a predictive marker for taxane-based chemotherapy in recurrent and metastatic gastric cancer

    International Nuclear Information System (INIS)

    Class III β-tubulin (TUBB3) is a prognostic marker in various tumors, but the role of TUBB3 in advanced gastric cancer is not clearly defined. We analyzed the significance of TUBB3 expression, along with that of excision repair cross-complementation group 1 (ERCC1) in recurrent and metastatic gastric cancer patients receiving taxane-based first-line palliative chemotherapy. We reviewed the cases of 146 patients with advanced gastric adenocarcinoma who received taxane-based first-line palliative chemotherapy between 2004 and 2010 at Chonnam National University Hwasun Hospital (Gwangju, Korea). Immunohistochemical staining for TUBB3 and ERCC1 was performed using paraffin wax-embedded tumor tissues. We evaluated the patients’ response to chemotherapy, progression-free survival (PFS), and overall survival (OS). In total, 146 patients with advanced gastric cancer received docetaxel and cisplatin (n = 15) or paclitaxel and cisplatin (n = 131). The median PFS was significantly shorter for patients with high-level TUBB3 expression than for patients with low-level TUBB3 expression (3.63 vs. 6.67 months, P = 0.001). OS was not associated with TUBB3 expression (13.1 vs. 13.1 months, P = 0.769). By multivariate analysis, only TUBB3 was related to a shorter PFS (HR 2.74, 95% CI 1.91-3.91, P = 0.001). Patients with high-level ERCC1 expression showed a lower response rate than patients with low-level ERCC1 expression (24 vs. 63.2%, P = 0.001); however, ERCC1 had no clinical effect on PFS or OS. TUBB3 was a strong predictive marker in recurrent and metastatic gastric cancer patients receiving taxane-based first-line palliative chemotherapy. No clinical impact of ERCC1 was evident in this setting

  6. The ERECTA, CLAVATA and class III HD-ZIP Pathways Display Synergistic Interactions in Regulating Floral Meristem Activities.

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    Udi Landau

    Full Text Available In angiosperms, the production of flowers marks the beginning of the reproductive phase. At the emergence of flower primordia on the flanks of the inflorescence meristem, the WUSCHEL (WUS gene, which encodes a homeodomain transcription factor starts to be expressed and establishes de novo stem cell population, founder of the floral meristem (FM. Similarly to the shoot apical meristem a precise spatial and temporal expression pattern of WUS is required and maintained through strict regulation by multiple regulatory inputs to maintain stem cell homeostasis. However, following the formation of a genetically determined fixed number of floral organs, this homeostasis is shifted towards organogenesis and the FM is terminated. In here we performed a genetic study to test how a reduction in ERECTA, CLAVATA and class III HD-ZIP pathways affects floral meristem activity and flower development. We revealed strong synergistic phenotypes of extra flower number, supernumerary whorls, total loss of determinacy and extreme enlargement of the meristem as compared to any double mutant combination indicating that the three pathways, CLV3, ER and HD-ZIPIII distinctively regulate meristem activity and that they act in parallel. Our findings yield several new insights into stem cell-driven development. We demonstrate the crucial requirement for coupling floral meristem termination with carpel formation to ensure successful reproduction in plants. We also show how regulation of meristem size and alternation in spatial structure of the meristem serve as a mechanism to determine flower organogenesis. We propose that the loss of FM determinacy due to the reduction in CLV3, ER and HD-ZIPIII activity is genetically separable from the AGAMOUS core mechanism of meristem termination.

  7. Cell wall-bound cationic and anionic class III isoperoxidases of pea root: biochemical characterization and function in root growth.

    Science.gov (United States)

    Kukavica, Biljana M; Veljovicc-Jovanovicc, Sonja D; Menckhoff, Ljiljana; Lüthje, Sabine

    2012-07-01

    Cell wall isolated from pea roots was used to separate and characterize two fractions possessing class III peroxidase activity: (i) ionically bound proteins and (ii) covalently bound proteins. Modified SDS-PAGE separated peroxidase isoforms by their apparent molecular weights: four bands of 56, 46, 44, and 41kDa were found in the ionically bound fraction (iPOD) and one band (70kDa) was resolved after treatment of the cell wall with cellulase and pectinase (cPOD). Isoelectric focusing (IEF) patterns for iPODs and cPODs were significantly different: five iPODs with highly cationic pI (9.5-9.2) were detected, whereas the nine cPODs were anionic with pI values between pH 3.7 and 5. iPODs and cPODs showed rather specific substrate affinity and different sensitivity to inhibitors, heat, and deglycosylation treatments. Peroxidase and oxidase activities and their IEF patterns for both fractions were determined in different zones along the root and in roots of different ages. New iPODs with pI 9.34 and 9.5 were induced with root growth, while the activity of cPODs was more related to the formation of the cell wall in non-elongating tissue. Treatment with auxin that inhibits root growth led to suppression of iPOD and induction of cPOD. A similar effect was obtained with the widely used elicitor, chitosan, which also induced cPODs with pI 5.3 and 5.7, which may be specifically related to pathogen defence. The differences reported here between biochemical properties of cPOD and iPOD and their differential induction during development and under specific treatments implicate that they are involved in specific and different physiological processes. PMID:22760472

  8. Apresentação de um caso clínico de Classe III de Angle, tratado com o aparelho extrabucal basculante inferior de ação reversa, proposto por Baptista Apresentation of a Angle Class III clinic case, treated with lower headgear of reverse action appliance, suggested by Baptista

    OpenAIRE

    Sylvio Gonçalves Filho; Andrea Chaves; Miguel Neil Benvenga

    2005-01-01

    As más oclusões de Classe III são as de menor incidência em nossas clínicas. Porém, a intervenção precoce têm-se mostrado muito importante para que não haja um agravamento do quadro, influenciando o comportamento psicossocial do paciente. Neste artigo serão demonstrados os resultados com um aparelho muito simples de usar, com boa colaboração dos pacientes e resultados animadores.Early treatment in patients with Class III maloclusion can avoid psychological disordes.The effects of orthopedic t...

  9. [Osteogenesis imperfecta and dentinogenesis imperfecta: diagnostic frontiers and importance in dentofacial orthopedics].

    Science.gov (United States)

    Kamoun-Goldrat, Agnès S; Le Merrer, Martine F

    2007-06-01

    Osteogenesis imperfecta is a genetic disease that varies in severity and is characterized by fragile bones that fracture easily. Many extra-skeletal manifestations can be noted such as blue sclerotic markings, dentinogenesis imperfecta and impaired hearing or deafness. In most cases, an anomaly of collagen is the cause. It is usually accompanied by a specific Class III type cranio-facial morphology with open bite and increased incidence of impacted permanent molars. Orthodontists called upon to treat the dental aspects of this malady, should be careful to protect their patients against bacterial infection and hemorrhages, and to be well aware of the side affects that can be caused by the biophosphanates that constitute the basis of current medical treatment of osteogenesis imperfecta.

  10. Evaluation of cephalometric changes in patients with class III malocclusion in mixed dentition period following face mask therapy and slow maxillary expansion

    Directory of Open Access Journals (Sweden)

    Ahmad Akhondi MS.

    2008-11-01

    Full Text Available "nBackground and Aim: Among different treatments of patients with Class III malocclusion , orthopedic protraction of maxilla has been known as an effective method in mixed dentition period. The aim of this study was to evaluate the cephalometric changes of Cl III patients in mixed dentition period following face mask therapy and slow maxillary expansion. "nMaterials and Methods: This was a before-after study which was conducted on 10 children in mixed dentition period, who had class III malocclusion and maxillary deficiency according to the Stiener and Mc Namara's analysis. The patients were all treated by protraction face mask and slow maxillary expansion. The cephalometric changes of maxilla , mandible and dental relations during the treatment were analyzed by Paired sample T Test. P<0.05 was considered as the level of significant. "nResults: The overjet increasement was 1.7mm. Co. ANS distance improvement was 5.6mm, Ptm.ANS distance increasing was 3mm, and ultimately improvement of Gf.s distance was 1.5mm which were all statistically significant (p<0.05. "nConclusion: Based on the results of this study, face mask therapy with slow maxillary expansion is able to improve the horizotal position of maxilla, in patients with Cl III malocclusion , in mixed dentition period.

  11. Dissatisfaction with dentofacial appearance and the normative need for orthodontic treatment: determinant factors

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    Anderson Barbosa de Almeida

    2014-06-01

    Full Text Available OBJECTIVE: This study aims at assessing the normative need for orthodontic treatment and the factors that determine the subjective impact of malocclusion on 12-year-old Brazilian school children. METHODS: A total of 451 subjects (215 males and 236 females were randomly selected from private and public schools of Juiz de Fora, Brazil. The collected data included sociodemographic information and occlusal conditions. The esthetic subjective impact of malocclusion was assessed by means of the Orthodontic Aesthetic Subjective Impact Score - OASIS, whereas the malocclusion and the need for orthodontic treatment were assessed by means of the Dental Aesthetic Index (DAI and the Index of Orthodontic Treatment Need-Aesthetic Component (IOTN-AC. RESULTS: Prevalence of normative need for orthodontic treatment was 65.6% (n = 155, and prevalence of orthodontic esthetic subjective impact was 14.9%. The following variables showed significant association with esthetic subjective impact of malocclusion: female (p = 0.042; OR = 0.5; CI = 0.2-0.9, public school student (p = 0.002; OR = 6.8; CI = 1.9-23.8, maxillary overjet ≥ 4 mm (p = 0.037; OR = 1.7; CI = 1-3 and gingival smile ≥ 4 mm (p = 0.008; OR = 3.4; CI = 1.3-8.8. CONCLUSION: The normative need for orthodontic treatment overestimated the perceived need. Occlusal and sociocultural factors influenced the dissatisfaction of schoolchildren with their dentofacial appearance.

  12. Frontal cephalometric evaluation of transverse dentofacial morphology and growth of children with isolated cleft palate.

    Science.gov (United States)

    Athanasiou, A E; Moyers, R E; Mazaheri, M; Toutountzakis, N

    1991-08-01

    The transverse dentofacial morphology and growth of 64 children operated on for clefting of the hard and soft palate was studied by means of a frontal proportional cephalometric analysis and was compared to a normal sample at the ages 3-4, 8-9 and 12 years. The cross-sectional comparison of the cleft palate and normal samples at the three periods indicated: (a) The presence in the cleft group of significantly increased ratios of the inner orbital width to the interorbital width and of the width of the nasal cavity to the interorbital width; (b) the absence of any significant differences in the ratio of the maxillary intermolar width to the interorbital width; and (c) the presence of almost identical ratios of the intergonial width of the mandible to the interorbital width and of the width of the maxilla to the intergonial width of the mandible. Evaluation of the changes of all cephalometric variables during the period 8-12 years showed the absence of any significant difference between the cleft palate and normal groups. PMID:1939671

  13. The effect of mouth breathing on dentofacial morphology of growing child

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    S Malhotra

    2012-01-01

    Full Text Available Backround: The oral mode of respiration cause postural adaptations of structures in the head and neck region producing the effect on the positional relationship of the jaws. Aim: The aim of this study is to verify the skeletal relationship of mouth and nose breathing child. Study design: A cross sectional study was performed to assess the association of changed mode of respiration with dentofacial growth. Materials and Methods : One hundred children among which 54 were mouth breathers and 46 were nasal breathers of 6-12 years of age were submitted to clinical examination and cephalometric radiographical analysis. Statistical analysis : Chi-square test for proportions and independent sample′s ′t′test for parametric data is used. Result: The mean values of N-Me (P<0.001 ANS-Me (P<0.001 and SN-GoGn (P<0.001 for mouth breathers is significantly higher. ArGo-GoMe (P=0.003 and (P<0.011 for 6-9 and 9-12 years age group, respectively, were significantly low in nasal breathers group. Conclusions: Changed mode of respiration was associated with increased facial height, mandibular plane angle and gonial angle.

  14. Oral Health and Dentofacial Anomalies among β-THALASSEMIA Major in Erbil City, Iraq

    Science.gov (United States)

    Saeed, Lamya M.; Majeed, Vian O.

    2010-04-01

    Thalassemias are a heterogeneous group of genetic disorders characterized by hypochromic microcytic anemia that caused by deficient synthesis of one or more of globin subunits of human hemoglobin. This study has been conducted in the Northern part of Iraq among 238 subjects having β-thalassemia major (BTM). To evaluate their oral health status, dentofacial anomalies of patients who attended the Thalassemic center in Erbil city, were compared to 258 subjects of a control group according to the criteria suggested by the WHO in 1997, which is used to assess permanent teeth. Only 8.51% of the total study group demonstrated crowding of anterior teeth in one or both segments compared to the control group. Spacing in the incisal segments was higher, namely 19.23% in BTM compared to13.6% in the control group with a statistically significant difference (pindices were recorded to be higher among the study group (plaque index = 1.570, ∓0.321 and gingival index = 1.205, ∓0.308). Differences were statistically highly significant for all indices (pindicate that there is a negative attitude and poor dental knowledge of thalassemic subjects and their parents toward proper oral hygiene and dental health.

  15. Pre-arthroplasty simultaneous maxillomandibular distraction osteogenesis for the correction of post-ankylotic dentofacial deformities.

    Science.gov (United States)

    Mehrotra, D; Vishwakarma, K; Chellapa, A L; Mahajan, N

    2016-07-01

    The aim of this study was to evaluate the hard and soft tissue changes after pre-arthroplasty simultaneous maxillomandibular distraction osteogenesis for the correction of post-ankylotic dentofacial deformities. This prospective study included 10 patients with unilateral temporomandibular joint (TMJ) ankylosis who presented with a facial deformity and a maxillary cant. Informed patient consent was obtained for participation. Simultaneous maxillomandibular distraction was planned based on clinical and radiographic examinations. A horizontal mandibular osteotomy was performed in the ramus and the distractor device was fixed. A bilateral Le Fort I osteotomy was then performed and a four-hole straight plate was fixed on the contralateral zygomatic buttress to act as a fulcrum. After a latency period of 5 days, the distractor was activated twice daily by 0.5mm until the required vertical lengthening was achieved. Intermaxillary fixation was maintained during the entire distraction period. After a consolidation period of 8-12 weeks, the distractor was removed. The TMJ ankylosis was released and a temporal fascia interpositional arthroplasty was performed as second surgery, along with a genioplasty if needed. All patients were followed up for a period of 12-24 months. A marked improvement in the facial asymmetry was noted in all cases. The occlusal cant and mandibular retrusion improved satisfactorily, and the average postoperative inter-incisal opening was 35.6mm. Pre-arthroplasty simultaneous maxillomandibular distraction offers a good treatment outcome, as it allows improvements in facial aesthetics as well as function. PMID:26780926

  16. TaqMan Probe-Based Real-Time PCR Assay for Detection and Discrimination of Class I, II, and III tfdA Genes in Soils Treated with Phenoxy Acid Herbicides▿ †

    OpenAIRE

    Bælum, Jacob; Jacobsen, Carsten S.

    2009-01-01

    Separate quantification of three classes of tfdA genes was performed using TaqMan quantitative real-time PCR for 13 different soils subsequent to mineralization of three phenoxy acids. Class III tfdA genes were found to be involved in mineralization more often than class I and II tfdA genes.

  17. Association between class III obesity (BMI of 40-59 kg/m2 and mortality: a pooled analysis of 20 prospective studies.

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    Cari M Kitahara

    2014-07-01

    Full Text Available BACKGROUND: The prevalence of class III obesity (body mass index [BMI]≥40 kg/m2 has increased dramatically in several countries and currently affects 6% of adults in the US, with uncertain impact on the risks of illness and death. Using data from a large pooled study, we evaluated the risk of death, overall and due to a wide range of causes, and years of life expectancy lost associated with class III obesity. METHODS AND FINDINGS: In a pooled analysis of 20 prospective studies from the United States, Sweden, and Australia, we estimated sex- and age-adjusted total and cause-specific mortality rates (deaths per 100,000 persons per year and multivariable-adjusted hazard ratios for adults, aged 19-83 y at baseline, classified as obese class III (BMI 40.0-59.9 kg/m2 compared with those classified as normal weight (BMI 18.5-24.9 kg/m2. Participants reporting ever smoking cigarettes or a history of chronic disease (heart disease, cancer, stroke, or emphysema on baseline questionnaires were excluded. Among 9,564 class III obesity participants, mortality rates were 856.0 in men and 663.0 in women during the study period (1976-2009. Among 304,011 normal-weight participants, rates were 346.7 and 280.5 in men and women, respectively. Deaths from heart disease contributed largely to the excess rates in the class III obesity group (rate differences = 238.9 and 132.8 in men and women, respectively, followed by deaths from cancer (rate differences = 36.7 and 62.3 in men and women, respectively and diabetes (rate differences = 51.2 and 29.2 in men and women, respectively. Within the class III obesity range, multivariable-adjusted hazard ratios for total deaths and deaths due to heart disease, cancer, diabetes, nephritis/nephrotic syndrome/nephrosis, chronic lower respiratory disease, and influenza/pneumonia increased with increasing BMI. Compared with normal-weight BMI, a BMI of 40-44.9, 45-49.9, 50-54.9, and 55-59.9 kg/m2 was associated with an

  18. Cephalometric analysis of hard and soft tissues in a 12-year-old syndromic child: A case report and update on dentofacial features of Crouzon syndrome

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    K Nagaraju

    2011-01-01

    Full Text Available Crouzon syndrome or craniofacial dysostosis is a rare syndrome characterized by craniosynostosis, midfacial hypoplasia and exophthalmia. The abnormalities found in this syndrome change too much from case to case depending on the suture fusion order. We report a case of a 12 year old child and a mother showing variations in the dentofacial tissues clinically and radiographically. Subsequently, the application of digital software [Dolphin Imaging 11] enabled us to solve out the case as Crouzon syndrome by analyzing the skeletal and soft tissue alterations. An update of the effects of this syndrome on various systems and dentofacial features with emphasis on tooth abnormalities is documented.

  19. The activity of class I, II, III and IV of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in brain cancer.

    Science.gov (United States)

    Laniewska-Dunaj, Magdalena; Jelski, Wojciech; Orywal, Karolina; Kochanowicz, Jan; Rutkowski, Robert; Szmitkowski, Maciej

    2013-07-01

    The brain being highly sensitive to the action of alcohol is potentially susceptible to its carcinogenic effects. Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are the main enzymes involved in ethanol metabolism, which leads to the generation of carcinogenic acetaldehyde. Human brain tissue contains various ADH isoenzymes and possess also ALDH activity. The purpose of this study was to compare the capacity for ethanol metabolism measured by ADH isoenzymes and ALDH activity in cancer tissues and healthy brain cells. The samples were taken from 62 brain cancer patients (36 glioblastoma, 26 meningioma). For the measurement of the activity of class I and II ADH isoenzymes and ALDH activity, the fluorometric methods were used. The total ADH activity and activity of class III and IV isoenzymes were measured by the photometric method. The total activity of ADH, and activity of class I ADH were significantly higher in cancer cells than in healthy tissues. The other tested classes of ADH and ALDH did not show statistically significant differences of activity in cancer and in normal cells. Analysis of the enzymes activity did not show significant differences depending on the location of the tumor. The differences in the activity of total alcohol dehydrogenase, and class I isoenzyme between cancer tissues and healthy brain cells might be a factor for metabolic changes and disturbances in low mature cancer cells and additionally might be a reason for higher level of acetaldehyde which can intensify the carcinogenesis.

  20. A study of the effectiveness for response to loss of Class IV power of one standby Class III generator operating in a continuous or test cycle mode

    International Nuclear Information System (INIS)

    This paper presents the results of a reliability study that models, evaluates and compares the effectiveness for response to loss of Class 4 power (LOCLIV) of a single available Class 3 standby generator (SG) at an operating CANDU plant. The modelling is based upon operating and licensing considerations at Point Lepreau Generating Station (PLGS) and is applicable to cases where one of its two SG's is out of service for maintenance when a LOCLIV event occurs. The different licensing requirements for two modes of SG operation, either continuous or in a series of successive testing cycles, when the reactor is shut down or operating at power, have been modelled. Techniques have been developed to convolve the modelled probability of occurrence of a LOCLIV at a particular time instant with the probability of successful SG response and Class 3 system reconfiguration from the existing operational state tot he required safety response state. The concepts, techniques and models developed to measure the response to a LOCLIV event by an SG in continuous or cyclic mode of operation are described in this paper. (author). 6 refs., 3 tabs., 10 figs

  1. Aplicações da distração osteogênica na região dentofacial: o estado da arte Dentofacial applications of distraction osteogenesis: the state of the art

    Directory of Open Access Journals (Sweden)

    Jorge Faber

    2005-08-01

    Full Text Available A distração osteogênica é uma forma de engenharia de tecidos na qual a separação gradual de margens ósseas cirurgicamente seccionadas resulta na geração de novo osso, cujo processo geral de regeneração é similar à ossificação intramembranosa. A técnica ganhou muitas aplicações na região dentofacial que variam da movimentação dentária a avanços da mandíbula ou da face média. Esse artigo revisa a literatura sobre o assunto com o objetivo de proporcionar ao ortodontista e ao cirurgião bucomaxilofacial uma abordagem atualizada das características biológicas e clínicas dessa técnica.Distraction osteogenesis is a tissue engineering technique in which the gradual separation of surgically sectioned bone edges results in the generation of new bone. The basic regeneration process is similar to intramembranous ossification. A great number of applications has been found for it in the dentofacial complex, ranging from tooth distraction to midface advancement. This article reviews the literature regarding distraction osteogenesis with the aim of providing the orthodontist and oral surgeon an updated approach to the clinical and biological aspects of this technique.

  2. Cone-Beam Computed Tomography Assessment of Lower Facial Asymmetry in Unilateral Cleft Lip and Palate and Non-Cleft Patients with Class III Skeletal Relationship.

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    Yifan Lin

    Full Text Available To evaluate, using cone-beam computed tomography (CBCT, both the condylar-fossa relationships and the mandibular and condylar asymmetries between unilateral cleft lip and palate (UCLP patients and non-cleft patients with class III skeletal relationship, and to investigate the factors of asymmetry contributing to chin deviation.The UCLP and non-cleft groups consisted of 30 and 40 subjects, respectively, in mixed dentition with class III skeletal relationships. Condylar-fossa relationships and the dimensional and positional asymmetries of the condyles and mandibles were examined using CBCT. Intra-group differences were compared between two sides in both groups using a paired t-test. Furthermore, correlations between each measurement and chin deviation were assessed.It was observed that 90% of UCLP and 67.5% of non-cleft subjects had both condyles centered, and no significant asymmetry was found. The axial angle and the condylar center distances to the midsagittal plane were significantly greater on the cleft side than on the non-cleft side (P=0.001 and P=0.028, respectively and were positively correlated with chin deviation in the UCLP group. Except for a larger gonial angle on the cleft side, the two groups presented with consistent asymmetries showing shorter mandibular bodies and total mandibular lengths on the cleft (deviated side. The average chin deviation was 1.63 mm to the cleft side, and the average absolute chin deviation was significantly greater in the UCLP group than in the non-cleft group (P=0.037.Compared with non-cleft subjects with similar class III skeletal relationships, the subjects with UCLP showed more severe lower facial asymmetry. The subjects with UCLP presented with more asymmetrical positions and rotations of the condyles on axial slices, which were positively correlated with chin deviation.

  3. Crescimento da base craniana nos diferentes tipos faciais nos relacionamentos maxilomandibulares ortopédicos de Classe I, II e III: Parte 2 (Crescimento médio de Ba-Na, CC-Na e CC-Ba Cranial base growth in different facial types in Class I, II and III orthopedic maxillomandibular relationship: Part 2 (Mean growth of Ba-Na, CC-Na and CC-Ba

    Directory of Open Access Journals (Sweden)

    Lucelma Vilela Pieri

    2007-04-01

    Full Text Available OBJETIVO: este estudo retrospectivo avaliou o crescimento médio da base craniana nos diferentes tipos faciais e de relacionamentos maxilomandibulares ortopédicos.METODOLOGIA: uma amostra aleatória de 300 pacientes brasileiros leucodermas (131 do gênero masculino, 169 do gênero feminino, com idade média inicial de 10 anos e 2 meses (dentadura mista e final de 14 anos e 8 meses (segundos molares em oclusão e tempo médio de observação de 4 anos e 5 meses, foi selecionada em uma clínica particular, em São Paulo, Brasil. Havia 118 Classe I, 151 Classe II e 31 Classe III. Todas as 600 radiografias cefalométricas laterais foram obtidas no mesmo aparelho de raios-x. As análises de Ricketts e Schwarz modificadas por Faltin foram usadas. As medidas lineares (Ba-Na, CC-Na e CC-Ba foram feitas manualmente pelo mesmo examinador em T1 e T2. Os relacionamentos foram estudados juntos e separadamente, considerando tipo facial e gênero. O teste t-pareado e ANOVA foram aplicados. RESULTADOS E CONCLUSÕES: o tipo facial retrovertido cresceu significantemente mais em CC-Na na Classe II, sendo a sua correção desfavorável no gênero feminino; com tendência favorável na Classe III e crescimento dentro do esperado na Classe I. O neutrovertido cresceu significantemente mais em CC-Na nas Classes I e II, sendo desfavorável na Classe II; com crescimento eqüitativo de CC-Na e CC-Ba na Classe III e levemente acima do esperado na Classe I. O provertido teve crescimento eqüitativo em todas as Classes, sendo significantemente favorável na Classe II mandibular; com tendência favorável na Classe III e crescimento médio acima do esperado na Classe I.AIM: This retrospective study evaluated the cranial base mean growth in different facial types and orthopedic maxillomandibular relationship. METHODS: A random sample of 300 Brazilian Caucasian patients (131 males, 169 females, initial and final mean age (10 years 2 months-mixed dentition; 14 years 8 months

  4. Application of Advanced Reservoir Characterization, Simulation, and Production Optimization Strategies to Maximize Recovery in Slope and Basin Clastic Reservoirs, West Texas (Delaware Basin), Class III

    Energy Technology Data Exchange (ETDEWEB)

    Dutton, Shirley P.; Flanders, William A.

    2001-11-04

    The objective of this Class III project was demonstrate that reservoir characterization and enhanced oil recovery (EOR) by CO2 flood can increase production from slope and basin clastic reservoirs in sandstones of the Delaware Mountain Group in the Delaware Basin of West Texas and New Mexico. Phase 1 of the project, reservoir characterization, focused on Geraldine Ford and East Ford fields, which are Delaware Mountain Group fields that produce from the upper Bell Canyon Formation (Ramsey sandstone). The demonstration phase of the project was a CO2 flood conducted in East Ford field, which is operated by Orla Petco, Inc., as the East Ford unit.

  5. Early orthodontic intervention followed by fixed appliance therapy in a patient with a severe Class III malocclusion and cleft lip and palate.

    Science.gov (United States)

    Zhang, He; Deng, Feng; Wang, Huaqiao; Huang, Qianqian; Zhang, Yi

    2013-11-01

    This case report describes the treatment of a girl, age 11 years 10 months, with a cleft lip and palate and a postsurgical scar. The clinical examination showed a concave profile, a retrusive maxilla, an asymmetric face, severe dental crowding, a Class III dental relationship, and a complete dental crossbite. Maxillary expansion and distraction, chincap, and high-pull headgear were used to moderate the skeletal discrepancy. These approaches, combined with tooth extraction and fixed orthodontic appliances, finally established a functional and esthetic occlusal relationship, normal overjet and overbite, and a well-balanced facial appearance.

  6. Relationship of physical activity and weight loss in women with Class II and Class III obesity: Mediation of exercise-induced changes in tension and depression

    OpenAIRE

    Annesi, James J.

    2010-01-01

    El ejercicio físico predice tanto la pérdida de peso como la mejora en el estado de ánimo. Debido al gasto energético mínimo relacionado con el ejercicio en personas obesas y a su pobre estado cardiovascular se sugirió que el cambio en el estado de ánimo inducido por el ejercicio puede mediar la relación de éste con la pérdida de peso. En el presente estudio experimental, mujeres con obesidad de Clase II y III (N = 75) participaron en un programa de ejercicio moderado y educación en nutrición...

  7. Application for Permit to Operate a Class III Solid Waste Disposal Site at the Nevada Test Site - U10c Disposal Site

    Energy Technology Data Exchange (ETDEWEB)

    NSTec Environmental Programs

    2010-08-05

    The NTS is located approximately 105 km (65 mi) northwest of Las Vegas, Nevada. NNSA/NSO is the federal lands management authority for the NTS and NSTec is the Management & Operations contractor. Access on and off the NTS is tightly controlled, restricted, and guarded on a 24-hour basis. The NTS is posted with signs along its entire perimeter. NSTec is the operator of all solid waste disposal sites on the NTS. The U10C Disposal Site is located in the northwest corner of Area 9 at the NTS (Figure 1) and is located in a subsidence crater created by two underground nuclear events, one in October 1962 and another in April 1964. The disposal site opened in 1971 for the disposal of rubbish, refuse, pathological waste, asbestos-containing material, and industrial solid waste. A Notice of Intent form to operate the disposal site as a Class II site was submitted to the state of Nevada on January 26, 1994, and was acknowledged in a letter to the DOE on February 8, 1994. It operated as a state of Nevada Class II Solid Waste Disposal Site (SWDS) until it closed on October 5, 1995, for retrofit as a Class III SWDS. The retrofit consisted of the installation of a minimum four-foot compacted soil layer to segregate the different waste types and function as a liner to inhibit leachate and water flow into the lower waste zone. Five neutron monitoring tubes were installed in this layer to monitor possible leachate production and water activity. Upon acceptance of the installed barrier and approval of an Operating Plan by NDEP/BFF, the site reopened in January 1996 as a Class III SWDS for the disposal of industrial solid waste and other inert waste.

  8. Apresentação de um caso clínico de Classe III de Angle, tratado com o aparelho extrabucal basculante inferior de ação reversa, proposto por Baptista Apresentation of a Angle Class III clinic case, treated with lower headgear of reverse action appliance, suggested by Baptista

    Directory of Open Access Journals (Sweden)

    Sylvio Gonçalves Filho

    2005-02-01

    Full Text Available As más oclusões de Classe III são as de menor incidência em nossas clínicas. Porém, a intervenção precoce têm-se mostrado muito importante para que não haja um agravamento do quadro, influenciando o comportamento psicossocial do paciente. Neste artigo serão demonstrados os resultados com um aparelho muito simples de usar, com boa colaboração dos pacientes e resultados animadores.Early treatment in patients with Class III maloclusion can avoid psychological disordes.The effects of orthopedic therapy an mandibular growth with Batista’s reverse arch is showd in this case, indicating that is possible to solve this maloclusion with efficacy.

  9. The Effects of Maxillary Protraction with or without Rapid Maxillary Expansion and Age Factors in Treating Class III Malocclusion: A Meta-Analysis.

    Directory of Open Access Journals (Sweden)

    Wei Zhang

    Full Text Available We conducted a comprehensive meta-analysis of 12 studies to examine whether maxillary protraction face mask associated with rapid maxillary expansion (FM/RME could be an effective treatment for Class III malocclusion and to evaluate the effect of timing on treatment response. Patients with a maxillary deficiency who were treated with FM with or without RME were compared with those who had an untreated Class III malocclusion. In both treatment groups, forward displacement of the maxilla and skeletal changes were found to be statistically significant. In addition, posterior rotation of the mandible and increased facial height were more evident in the FM group compared with the control group. However, no significant differences were observed between the early treatment groups and late treatment groups. The results indicated that both FM/RME and FM therapy produced favorable skeletal changes for correcting anterior crossbite, and the curative time was not affected by the presence of deciduous teeth, early mixed dentition or late mixed dentition in the patient.

  10. Orthopedic treatment of Class III malocclusion with rapid maxillary expansion combined with a face mask: a cephalometric assessment of craniofacial growth patterns

    Directory of Open Access Journals (Sweden)

    Daniella Torres Tagawa

    2012-06-01

    Full Text Available OBJECTIVE: The aim of this prospective study was to assess potential changes in the cephalometric craniofacial growth pattern of 17 children presenting Angle Class III malocclusion treated with a Haas-type expander combined with a face mask. METHODS: Lateral cephalometric radiographs were taken at beginning (T1 and immediately after removal of the appliances (T2, average of 11 months of treatment. Linear and angular measurements were used to evaluate the cranial base, dentoskeletal changes and facial growth pattern. RESULTS: The length of the anterior cranial base experienced a reduction while the posterior cranial base assumed a more vertical position at T1. Some maxillary movement occurred, there was no rotation of the palatal plane, there was a slight clockwise rotation of the mandible, although not significant. The ANB angle increased, thereby improving the relationship between the jaws; dentoalveolar compensation was more evident in the lower incisors. Five out of 12 cases (29.41% showed the following changes: In one case the pattern became more horizontal and in four cases more vertical. CONCLUSIONS: It was concluded after a short-term assessment that treatment with rapid maxillary expansion (RME associated with a face mask was effective in the correction of Class III malocclusion despite the changes in facial growth pattern observed in a few cases.

  11. Two-Stage Mucogingival Surgery with Free Gingival Autograft and Biomend Membrane and Coronally Advanced Flap in Treatment of Class III Millers Recession.

    Science.gov (United States)

    Rath, Avita; Varma, Smrithi; Paul, Renny

    2016-01-01

    Introduction. Gingival recession is an apical shift of the gingival margin with exposure of the root surface. This migration of the marginal tissue leads to esthetic concerns, dentin hypersensitivity, root caries, and cervical wear. It is, paradoxically, a common finding in patients with a high standard of oral hygiene, as well as in periodontally untreated populations with poor oral hygiene. Changing the topography of the marginal soft tissue in order to facilitate plaque control is a common indication for root coverage procedures and forms a major aspect of periodontal plastic surgeries. The regeneration of a new connective tissue attachment to denuded root surface is by allowing the selective coronal regrowth of periodontal ligament cells while excluding the gingival tissues from the root during wound healing by means of a barrier membrane. Case Presentation. This case reports a two-stage surgical technique for treatment of Miller's class III defect using free gingival autograft and type I absorbable collagen membrane (BioMend®, Zimmer Dental, USA)(§). Conclusions. The 6-month follow-up of the case showed a significant increase in attached gingiva suggesting it as a predictable alternative in the treatment of Millers class III defects. PMID:27525131

  12. Molecular Cloning and Characterization of a Vacuolar Class III Peroxidase Involved in the Metabolism of Anticancer Alkaloids in Catharanthus roseus1[C

    Science.gov (United States)

    Costa, Maria Manuela R.; Hilliou, Frederique; Duarte, Patrícia; Pereira, Luís Gustavo; Almeida, Iolanda; Leech, Mark; Memelink, Johan; Barceló, Alfonso Ros; Sottomayor, Mariana

    2008-01-01

    Catharanthus roseus produces low levels of two dimeric terpenoid indole alkaloids, vinblastine and vincristine, which are widely used in cancer chemotherapy. The dimerization reaction leading to α-3′,4′-anhydrovinblastine is a key regulatory step for the production of the anticancer alkaloids in planta and has potential application in the industrial production of two semisynthetic derivatives also used as anticancer drugs. In this work, we report the cloning, characterization, and subcellular localization of an enzyme with anhydrovinblastine synthase activity identified as the major class III peroxidase present in C. roseus leaves and named CrPrx1. The deduced amino acid sequence corresponds to a polypeptide of 363 amino acids including an N-terminal signal peptide showing the secretory nature of CrPrx1. CrPrx1 has a two-intron structure and is present as a single gene copy. Phylogenetic analysis indicates that CrPrx1 belongs to an evolutionary branch of vacuolar class III peroxidases whose members seem to have been recruited for different functions during evolution. Expression of a green fluorescent protein-CrPrx1 fusion confirmed the vacuolar localization of this peroxidase, the exact subcellular localization of the alkaloid monomeric precursors and dimeric products. Expression data further supports the role of CrPrx1 in α-3′,4′-anhydrovinblastine biosynthesis, indicating the potential of CrPrx1 as a target to increase alkaloid levels in the plant. PMID:18065566

  13. The Effect of early physiotherapy on the recovery of mandibular function after orthognathic surgery for Class III correction: part I--jaw-motion analysis.

    Science.gov (United States)

    Teng, Terry Te-Yi; Ko, Ellen Wen-Ching; Huang, Chiung Shing; Chen, Yu-Ray

    2015-01-01

    The aim of this prospective study was to compare the mandibular range of motion in Class III patients with and without early physiotherapy after orthognathic surgery (OGS). This study consisted of 63 Class III patients who underwent 2-jaw OGS. The experimental group comprised 31 patients who received early systematic physical rehabilitation. The control group consisted of 32 patients who did not have physical rehabilitation. Twelve variables of 3-dimensional (3D) jaw-motion analysis (JMA) were recorded before surgery (T1) and 6 weeks (T2) and 6 months (T3) after surgery. A 2-sample t test was conducted to compare the JMA results between the two groups at different time points. At T2, the JMA data were measured to be 77.5%-145.7% of presurgical values in the experimental group, and 60.3%-90.6% in the control group. At T3, the measurements were 112.2%-179.2% of presurgical values in the experimental group, and 77.6%-157.2% in the control group. The patients in the experimental group exhibited more favorable recovery than did those in the control group, from T1 to T2 and T1 to T3. However, after termination of physiotherapy, no significant difference in the extent of recovery was observed between groups up to 6 months after OGS.

  14. Effects of two alar base suture techniques suture techniques on nasolabial changes after bimaxillary orthognathic surgery in Taiwanese patients with class III malocclusions.

    Science.gov (United States)

    Chen, C Y-H; Lin, C C-H; Ko, E W-C

    2015-07-01

    A randomized controlled trial was designed to assess the effectiveness of two alar base cinch techniques on the changes in nasolabial morphology after bimaxillary orthognathic surgery. Sixty patients requiring a Le Fort I osteotomy to correct skeletal discrepancies were selected randomly to receive either conventional or modified alar base cinching during the intraoral wound closure procedure. Conventional cinching passed through nasalis muscle and anterior nasal spine. Modified cinching also passed through dermis tissue to increase the anchorage. Postoperative hard and soft tissue changes were evaluated using cone beam computed tomography and three-dimensional stereophotogrammetry at predefined time points. Forty-eight patients with a skeletal class III malocclusion were included. In the conventional group, there was an increase of 0.31 ± 1.31 mm in nasal width and an increase of 0.97 ± 1.60mm in columellar length. In the modified group, there was an increase of 0.81 ± 1.87 mm in the cutaneous height of the upper lip and a decrease of 0.76 ± 1.56 mm in lower prolabial width. Patients with an initial narrow nasal width, alar base width, and less vertical nostril show were more susceptible to a greater degree of change after surgery. Both alar base suture techniques are effective at controlling nasolabial form changes resulting from class III dual-jaw orthognathic surgery.

  15. Two-Stage Mucogingival Surgery with Free Gingival Autograft and Biomend Membrane and Coronally Advanced Flap in Treatment of Class III Millers Recession

    Science.gov (United States)

    Paul, Renny

    2016-01-01

    Introduction. Gingival recession is an apical shift of the gingival margin with exposure of the root surface. This migration of the marginal tissue leads to esthetic concerns, dentin hypersensitivity, root caries, and cervical wear. It is, paradoxically, a common finding in patients with a high standard of oral hygiene, as well as in periodontally untreated populations with poor oral hygiene. Changing the topography of the marginal soft tissue in order to facilitate plaque control is a common indication for root coverage procedures and forms a major aspect of periodontal plastic surgeries. The regeneration of a new connective tissue attachment to denuded root surface is by allowing the selective coronal regrowth of periodontal ligament cells while excluding the gingival tissues from the root during wound healing by means of a barrier membrane. Case Presentation. This case reports a two-stage surgical technique for treatment of Miller's class III defect using free gingival autograft and type I absorbable collagen membrane (BioMend®, Zimmer Dental, USA)§. Conclusions. The 6-month follow-up of the case showed a significant increase in attached gingiva suggesting it as a predictable alternative in the treatment of Millers class III defects. PMID:27525131

  16. The effect of implant placement in patients with either Kennedy class II and III on oral health-related quality of life: a prospective clinical trial.

    Science.gov (United States)

    van Eekeren, P J A; Aartman, I H A; Tahmaseb, A; Wismeijer, D

    2016-04-01

    There is little evidence of the effect of implants restored with fixed partial dentures on oral health-related quality of life (OHRQoL) in partially edentulous Kennedy class II and III patients. The aim of this study was to determine the change in OHRQoL in Kennedy classification II and III patients treated with a two-implant-supported fixed dental prosthesis (FDP). Kennedy class II and III patients received dental implants and an FDP. Oral health-related quality of life was measured by administration of the Oral Health Impact Profile-14 (OHIP-14NL) questionnaire at intake (T1), 2 weeks after surgery (T2) and after 1 year of loading (T3). The mean OHIP score at T1 was 6·5 ± 1·2, 2·4 ± 1·0 at T2, and 0·9 ± 0·3 at T3. There was a statistically significant difference between T1 and T2 (P = 0·002) and T1 and T3 (P < 0·001) but not between T2 and T3 (P = 0·407). The OHIP score in Kennedy II patients decreased from 4·8 ± 3·2 at T1 to 1·5 ± 2·0 at T2 and 1·1 ± 1·8 at T3, and that in Kennedy III patients decreased from 8·9 ± 9·6 at T1 to 3·6 ± 8·9 at T2 and 0·8 ± 2·2 at T3. There were no statistically significant differences in the reductions in Kennedy II and III patients. Oral health-related quality of life changed positively in patients treated with implants and an FDP in both groups. There was no change in OHRQoL between the times of implant placement and FDP placement. PMID:26599422

  17. Relationship of physical activity and weight loss in women with Class II and Class III obesity: Mediation of exercise-induced changes in tension and depression

    Directory of Open Access Journals (Sweden)

    James J. Annesi

    2010-01-01

    Full Text Available El ejercicio físico predice tanto la pérdida de peso como la mejora en el estado de ánimo. Debido al gasto energético mínimo relacionado con el ejercicio en personas obesas y a su pobre estado cardiovascular se sugirió que el cambio en el estado de ánimo inducido por el ejercicio puede mediar la relación de éste con la pérdida de peso. En el presente estudio experimental, mujeres con obesidad de Clase II y III (N = 75 participaron en un programa de ejercicio moderado y educación en nutrición durante 24 semanas en centros de la Asociación Cristiana de Jóvenes (YMCA en el sudeste de Estados Unidos. Tal como se esperaba, la participación en las sesiones de ejercicio se relacionó con la pérdida de peso (¿ = -.47, pero, de forma directa, representaron solamente un 17% de la pérdida de peso. Utilizando la aproximación de Baron y Kenny, se encontró una mediación parcial significativa para los cambios en 24 semanas en las puntuaciones de tensión y depresión. Esto sugiere que el ejercicio afectó indirectamente al cambio de peso mediante vías psicológicas y apoyó los principios de la teoría social cognitiva. Después de la replicación, los resultados pueden ayudar a mejorar las teorías explicativas y los tratamientos de control de peso.

  18. Characteristics and prevalence within serogroup O4 of a J96-like clonal group of uropathogenic Escherichia coli O4:H5 containing the class I and class III alleles of papG.

    Science.gov (United States)

    Johnson, J R; Stapleton, A E; Russo, T A; Scheutz, F; Brown, J J; Maslow, J N

    1997-01-01

    The recent discovery of a geographically dispersed clonal group of Escherichia coli O4:H5 that includes prototypic uropathogenic strain J96 prompted us to determine the prevalence of J96-like strains within serogroup O4 and to further assess the characteristics of such strains. We used O:K:H;F serotyping, PCR-based genomic fingerprinting, pulsed-field gel electrophoresis (PFGE), multilocus enzyme electrophoresis (MLEE), and PCR detection of the three papG alleles and of the cytotoxic necrotizing factor 1 (cnf1) and aerobactin (aer) gene sequences to characterize the 15 O4 strains among 336 E. coli isolates from three clinical collections (187 from mixed-source bacteremia, 75 from urosepsis, and 74 from acute cystitis). J96-like strains constituted approximately half of the O4 strains, or 2% of the total population. In contrast to other O4 strains, the J96-like strains characteristically exhibited specific group III capsular antigens, the H5 flagellar and F13 fimbrial antigens, a distinctive PCR genomic fingerprint, the class III papG allele (plus, in 50% of strains, the enigmatic class I papG allele), and cnf1 but lacked aer. A subset of these strains was remarkably homogeneous with respect to all these characteristics and exhibited a distinctive PFGE fingerprint and MLEE pattern. These findings clarify the epidemiological relevance of J96 as a model extraintestinal pathogen, provide further evidence of the class I papG allele outside of strain J96, and offer insights into the evolution of E. coli serogroup O4. PMID:9169745

  19. Effects of lifestyle interventions that include a physical activity component in class II and III obese individuals: a systematic review and meta-analysis.

    Directory of Open Access Journals (Sweden)

    Aurélie Baillot

    Full Text Available In class II and III obese individuals, lifestyle intervention is the first step to achieve weight loss and treat obesity-related comorbidities before considering bariatric surgery. A systematic review, meta-analysis, and meta-regression were performed to assess the impact of lifestyle interventions incorporating a physical activity (PA component on health outcomes of class II and III obese individuals.An electronic search was conducted in 4 databases (Medline, Scopus, CINAHL and Sportdiscus. Two independent investigators selected original studies assessing the impact of lifestyle interventions with PA components on anthropometric parameters, cardiometabolic risk factors (fat mass, blood pressure, lipid and glucose metabolism, behaviour modification (PA and nutritional changes, and quality of life in adults with body mass index (BMI ≥ 35 kg/m2. Estimates were pooled using a random-effect model (DerSimonian and Laird method. Heterogeneity between studies was assessed by the Cochran's chi-square test and quantified through an estimation of the I².Of the 3,170 identified articles, 56 met our eligibility criteria, with a large majority of uncontrolled studies (80%. The meta-analysis based on uncontrolled studies showed significant heterogeneity among all included studies. The pooled mean difference in weight loss was 8.9 kg (95% CI, 10.2-7.7; p < 0.01 and 2.8 kg/m² in BMI loss (95% CI, 3.4-2.2; p < 0.01. Long-term interventions produced superior weight loss (11.3 kg compared to short-term (7.2 kg and intermediate-term (8.0 kg interventions. A significant global effect of lifestyle intervention on fat mass, waist circumference, blood pressure, total cholesterol, LDL-C, triglycerides and fasting insulin was found (p<0.01, without significant effect on HDL-C and fasting blood glucose.Lifestyle interventions incorporating a PA component can improve weight and various cardiometabolic risk factors in class II and III obese individuals. However, further

  20. Study on Tensile Fatigue Behavior of Thermal Butt Fusion in Safety Class III High-Density Polyethylene Buried Piping in Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jong Sung; Lee, Young Ju [Sunchon National University, Suncheon (Korea, Republic of); Oh, Young Jin [KEPCO E and C, Yongin (Korea, Republic of)

    2015-01-15

    High-density polyethylene (HDPE) piping, which has recently been applied to safety class III piping in nuclear power plants, can be butt-joined through the thermal fusion process, which heats two fused surfaces and then subject to axial pressure. The thermal fusion process generates bead shapes on the butt fusion. The stress concentrations caused by the bead shapes may reduce the fatigue lifetime. Thus, investigating the effect of the thermal butt fusion beads on fatigue behavior is necessary. This study examined the fatigue behavior of thermal butt fusion via a tensile fatigue test under stress-controlled conditions using finite element elastic stress analysis. Based on the results, the presence of thermal butt fusion beads was confirmed to reduce the fatigue lifetime in the low-cycle fatigue region while having a negligible effect in the medium- and high-cycle fatigue regions.

  1. BtcA, A class IA type III chaperone, interacts with the BteA N-terminal domain through a globular/non-globular mechanism.

    Directory of Open Access Journals (Sweden)

    Chen Guttman

    Full Text Available Bordetella pertussis, the etiological agent of "whooping cough" disease, utilizes the type III secretion system (T3SS to deliver a 69 kDa cytotoxic effector protein, BteA, directly into the host cells. As with other T3SS effectors, prior to its secretion BteA binds BtcA, a 13.9 kDa protein predicted to act as a T3SS class IA chaperone. While this interaction had been characterized for such effector-chaperone pairs in other pathogens, it has yet to be fully investigated in Bordetella. Here we provide the first biochemical proof that BtcA is indeed a class IA chaperone, responsible for the binding of BteA's N-terminal domain. We bring forth extensive evidence that BtcA binds its substrate effector through a dual-interface binding mechanism comprising of non-globular and bi-globular interactions at a moderate micromolar level binding affinity. We demonstrate that the non-globular interactions involve the first 31 N-terminal residues of BteA287 and their removal leads to destabilization of the effector-chaperone complex and lower binding affinities to BtcA. These findings represent an important first step towards a molecular understanding of BteA secretion and cell entry.

  2. Crescimento da base craniana nos diferentes tipos faciais nos relacionamentos maxilomandibulares ortopédicos de Classe I, II e III: parte 1 Cranial base growth in different facial types in Class I, II and III orthopedic maxillomandibular relationship: part 1

    OpenAIRE

    Lucelma Vilela Pieri; Kurt Faltin Junior; Cristina Lúcia Feijó Ortolani; Rolf Marçon Faltin; Márcia Aparecida Alves de Almeida

    2007-01-01

    OBJETIVO: este estudo retrospectivo avaliou o crescimento médio anual da base craniana nos diferentes tipos faciais nos relacionamentos maxilomandibulares ortopédicos de Classe I, II e III. METODOLOGIA: uma amostra aleatória de 300 pacientes brasileiros leucodermas (131 do gênero masculino, 169 do gênero feminino), com idade média inicial de 10 anos e 2 meses (dentadura mista) e final de 14 anos e 8 meses (segundos molares em oclusão) e tempo médio de observação de 4 anos e 5 meses, foi selec...

  3. Crescimento da base craniana nos diferentes tipos faciais nos relacionamentos maxilomandibulares ortopédicos de Classe I, II e III: parte 3 (Crescimento médio de CF-Po) Cranial base growth in different facial types in Class I, II and III orthopedic maxillomandibular relationship: part 3 (Mean growth of CF-Po)

    OpenAIRE

    Lucelma Vilela Pieri; Kurt Faltin Junior; Cristina Lúcia Feijó Ortolani; Rolf Marçon Faltin; Márcia Aparecida Alves de Almeida

    2007-01-01

    OBJETIVO: este estudo retrospectivo avaliou o crescimento médio de CF-Po nos diferentes tipos faciais nos relacionamentos maxilomandibulares ortopédicos de Classe I, II e III. METODOLOGIA: uma amostra aleatória de 300 pacientes brasileiros leucodermas (131 do gênero masculino, 169 do gênero feminino), com idade média inicial de 10 anos e 2 meses (dentadura mista) e final de 14 anos e 8 meses (segundos molares em oclusão) e tempo médio de observação de 4 anos e 5 meses, foi selecionada em uma ...

  4. A method for establishing class III medical device equivalence: sodium hyaluronate (GenVisc 850 for the treatment of knee osteoarthritis

    Directory of Open Access Journals (Sweden)

    Doros G

    2016-07-01

    Full Text Available Gheorghe Doros,1 Philip T Lavin,2 Michael Daley,3 Larry E Miller4 1School of Public Health, Boston University, Boston, 2Lavin Consulting LLC, Framingham, MA, 3OrthogenRx Inc., Doylestown, PA, 4Miller Scientific Consulting, Inc., Asheville, NC, USA Abstract: Although the concept of equivalence for drugs (generics and biologics (biosimilars has been readily adopted, the concept of equivalence or indistinguishable characteristics for class III medical devices has yet to be specifically addressed regarding a defined regulatory approval process in the US. In September 2015, GenVisc 850® (sodium hyaluronate, a hyaluronic acid approved for the treatment of knee osteoarthritis, was approved by the US Food and Drug Administration (FDA based upon indistinguishable characteristics in comparison to an approved branded hyaluronic acid (Supartz®/Supartz FX™. The purpose of this paper is to review the methodology and report the main outcomes used to demonstrate clinical comparability of GenVisc 850 with Supartz/Supartz FX. The FDA approval was collectively attained using prospectively defined methods for preclinical, physical, and chemical testing, as well as noninferiority in clinical performance comparisons. Evidence from five randomized controlled studies of Supartz/Supartz FX vs saline control injections (used for Supartz approval, two randomized controlled trials of GenVisc 850 vs saline control injections, and one randomized controlled study of GenVisc 850 vs Supartz/Supartz FX provided evidence of safety for GenVisc 850. Efficacy was further assessed based on assessment of the same Supartz studies and three prospectively identified GenVisc 850 studies. A Bayesian network meta-analysis was used to demonstrate that the clinical efficacy of GenVisc 850 was noninferior to Supartz/Supartz FX and superior to saline control. Overall, safety of GenVisc 850 was similar to that of Supartz/Supartz FX and saline control injections, while efficacy of GenVisc 850

  5. A Cephalometric Study on the Relationship between the Occlusal Plane, Ala-Tragus and Camper’s Lines, in Patients with Angle’s Class III Malocclusion

    Directory of Open Access Journals (Sweden)

    F. Rostamkhani

    2005-06-01

    Full Text Available Statement of Problem: Considering the importance of the occlusal plane orientation in complete denture prostheses, a study was conducted on the relationship between this plane with ala-tragus and Camper’s lines in soft tissue among individuals with class IIImalocclusion, in Mashhad School of Dentistry.Purpose: The aim of the present study was to define the best soft tissue index by which the location and inclination of the occlusal plane in complete dentures could be established.Materials and methods: The participants consisted of 13 males with Angle’s class III occlusal relationship. Radiopaque markers were attached to the intended points on soft tissue and then standard lateral cephalograms were obtained from each subject.The angles between the following lines were measured: Occlusal line (OL, Camper's line (ala-porion, AT1 (ala-superior border of tragus, AT2 (ala- mid-tragus and AT3 (ala-inferior border of tragus.Results: The mean values and standard deviations calculated from the measured variables are as follows: OL-^AT1, 5.65 (3.95 degrees; OL- ^AT2, 3.19 (2.45 degrees;OL- ^AT3, 2.92 (2.42 degrees and OL- ^Camper, 8.5 (3.83 degrees. Comparison of the results by the ANOVA test exhibited a significant difference (F=3.7, P=0.05. Asthe OL^-AT3 angle had the lowest value, the occlusal line had a stronger tendency to be parallel to the AT3 line.Conclusion: According to the present study, the inferior border of the tragus is suggested as the posterior point for ala-tragus line orientation.

  6. Sirtuin and pan-class I/II deacetylase (DAC) inhibition is synergistic in preclinical models and clinical studies of lymphoma.

    Science.gov (United States)

    Amengual, Jennifer E; Clark-Garvey, Sean; Kalac, Matko; Scotto, Luigi; Marchi, Enrica; Neylon, Ellen; Johannet, Paul; Wei, Ying; Zain, Jasmine; O'Connor, Owen A

    2013-09-19

    Understanding the molecular pathogenesis of lymphoma has led to paradigm-changing treatment opportunities. One example involves tailoring specific agents based on the cell of origin in aggressive lymphomas. Germinal center (GC)-derived diffuse large B-cell lymphoma (DLBCL) is known to be driven by an addiction to Bcl6, whereas the activated B-cell (ABC) subtype is driven by nuclear factor κB. In the GC subtype, there is a critical inverse relationship between Bcl6 and p53, the functional status of which is linked to each transcription factor's degree of acetylation. Deacetylation of Bcl6 is required for its transcriptional repressor effects allowing for the oncogene to drive lymphomagenesis. Conversely, acetylation of p53 is activating when class III deacetylases (DACs), or sirtuins, are inhibited by niacinamide. Treatment of DLBCL cell lines with pan-DAC inhibitors in combination with niacinamide produces synergistic cytotoxicity in GC over ABC subtypes. This correlated with acetylation of both Bcl6 and p53. This combination also produced remissions in a spontaneous aggressive B-cell lymphoma mouse model expressing Bcl6. In a phase 1 proof-of-principle clinical trial, 24% of patients with relapsed or refractory lymphoma attained a response to vorinostat and niacinamide, and 57% experienced disease stabilization. We report herein on the preclinical and clinical activity of this targeted strategy in aggressive lymphomas. This trial was registered at www.clinicaltrials.gov as #NCT00691210.

  7. The Composition of Metals Bound to Class III Metallothionein (Phytochelatin and Its Desglycyl Peptide) Induced by Various Metals in Root Cultures of Rubia tinctorum.

    Science.gov (United States)

    Maitani, T.; Kubota, H.; Sato, K.; Yamada, T.

    1996-04-01

    The induction of phytochelatins (PCs) and their desglycyl peptides (both are referred to as class III metallothionein [CIIIMT]) by exposure to various metals (Ag+, As3+, As5+, Cd2+, Cu2+, Ga3+, Hg2+, In3+, Ni2+, Pb2+, Pd2+, Se4+, and Zn2+) and the metal composition in the CIIIMTs were investigated in root cultures of Rubia tinctorum L. All of these metal species induced PCs to various degrees when analyzed by the postcolumn derivatization high-performance liquid chromatography method. The desglycyl peptides of PCs often were also present. However, only Ag, Cd, and Cu were bound to the CIIIMTs that they induced when analyzed by the high-performance liquid chromatography-inductively coupled plasma-atomic emission spectrometry method. Cu was also bound to the CIIIMTs induced by Ag+, As3+, and Cd2+. After Ag+ exposure, an Fe peak that may be of Fe-CIIIMT was also observed. However, most of the metal species studied were not bound to the CIIIMTs that they induced. PMID:12226248

  8. The Use of Invisalign® System in the Management of the Orthodontic Treatment before and after Class III Surgical Approach

    Directory of Open Access Journals (Sweden)

    Renato Pagani

    2016-01-01

    Full Text Available The approach to skeletal dysmorphisms in the maxillofacial area usually requires an orthodontic treatment by means of fixed appliances, both before and after the surgical phase. Since its introduction, Invisalign system has become a popular treatment choice for the clinicians because of the aesthetics and comfort of the removable clear aligners compared with the traditional appliances. Therefore, the aim of the present report was to illustrate the management of a malocclusion by means of Invisalign system associated with the traditional surgical technique. The present paper shows a case of a 23-year-old male patient characterized by a Class III malocclusion with lateral deviation of the mandible to the left side and cross-bite on teeth 2.2, 2.3, and 2.4. Invisalign system was used during the pre- and postsurgical phases rather than fixed appliances. The posttreatment cephalometric analysis emphasized the stability of the dental and skeletal symmetry corrections, occlusion and functional balance, over a 6-year follow-up. The results achieved at the end of the treatment showed how Invisalign can be effective in the management of the orthodontic phases in orthognathic surgery. The follow-up after 6 years emphasizes the stability of the treatment over time.

  9. The Use of Invisalign® System in the Management of the Orthodontic Treatment before and after Class III Surgical Approach

    Science.gov (United States)

    2016-01-01

    The approach to skeletal dysmorphisms in the maxillofacial area usually requires an orthodontic treatment by means of fixed appliances, both before and after the surgical phase. Since its introduction, Invisalign system has become a popular treatment choice for the clinicians because of the aesthetics and comfort of the removable clear aligners compared with the traditional appliances. Therefore, the aim of the present report was to illustrate the management of a malocclusion by means of Invisalign system associated with the traditional surgical technique. The present paper shows a case of a 23-year-old male patient characterized by a Class III malocclusion with lateral deviation of the mandible to the left side and cross-bite on teeth 2.2, 2.3, and 2.4. Invisalign system was used during the pre- and postsurgical phases rather than fixed appliances. The posttreatment cephalometric analysis emphasized the stability of the dental and skeletal symmetry corrections, occlusion and functional balance, over a 6-year follow-up. The results achieved at the end of the treatment showed how Invisalign can be effective in the management of the orthodontic phases in orthognathic surgery. The follow-up after 6 years emphasizes the stability of the treatment over time. PMID:27429811

  10. The effect of early physiotherapy on the recovery of mandibular function after orthognathic surgery for class III correction. Part II: electromyographic activity of masticatory muscles.

    Science.gov (United States)

    Ko, Ellen Wen-Ching; Teng, Terry Te-Yi; Huang, Chiung Shing; Chen, Yu-Ray

    2015-01-01

    The study was conducted to evaluate the effect of early physical rehabilitation by comparing the differences of surface electromyographic (sEMG) activity in the masseter and anterior temporalis muscles after surgical correction of skeletal class III malocclusion. The prospective study included 63 patients; the experimental groups contained 31 patients who received early systematic physical rehabilitation; the control group (32 patients) did not receive physiotherapy. The amplitude of sEMG in the masticatory muscles reached 72.6-121.3% and 37.5-64.6% of pre-surgical values in the experimental and control groups respectively at 6 weeks after orthognathic surgery (OGS). At 6 months after OGS, the sEMG reached 135.1-233.4% and 89.6-122.5% of pre-surgical values in the experimental and control groups respectively. Most variables in the sEMG examination indicated that recovery of the masticatory muscles in the experimental group was better than the control group as estimated in the early phase (T1 to T2) and the total phase (T1 to T3); there were no significant differences between the mean recovery percentages in the later phase (T2 to T3). Early physical rehabilitative therapy is helpful for early recovery of muscle activity in masticatory muscles after OGS. After termination of physical therapy, no significant difference in recovery was indicated in patients with or without early physiotherapy.

  11. The Use of Invisalign® System in the Management of the Orthodontic Treatment before and after Class III Surgical Approach.

    Science.gov (United States)

    Pagani, Renato; Signorino, Fabrizio; Poli, Pier Paolo; Manzini, Pietro; Panisi, Irene

    2016-01-01

    The approach to skeletal dysmorphisms in the maxillofacial area usually requires an orthodontic treatment by means of fixed appliances, both before and after the surgical phase. Since its introduction, Invisalign system has become a popular treatment choice for the clinicians because of the aesthetics and comfort of the removable clear aligners compared with the traditional appliances. Therefore, the aim of the present report was to illustrate the management of a malocclusion by means of Invisalign system associated with the traditional surgical technique. The present paper shows a case of a 23-year-old male patient characterized by a Class III malocclusion with lateral deviation of the mandible to the left side and cross-bite on teeth 2.2, 2.3, and 2.4. Invisalign system was used during the pre- and postsurgical phases rather than fixed appliances. The posttreatment cephalometric analysis emphasized the stability of the dental and skeletal symmetry corrections, occlusion and functional balance, over a 6-year follow-up. The results achieved at the end of the treatment showed how Invisalign can be effective in the management of the orthodontic phases in orthognathic surgery. The follow-up after 6 years emphasizes the stability of the treatment over time.

  12. Class I malocclusion with anterior crossbite and severe crowding

    Directory of Open Access Journals (Sweden)

    Daltro Enéas Ritter

    2014-04-01

    Full Text Available This article reports the orthodontic diagnosis and treatment planning carried out with a 14-year and 5-month-old female patient with esthetic and functional complaints. She presented an Angle Class I malocclusion, anterior crossbite and severe crowding in both maxillary and mandibular arches, in addition to a lightly concave straight facial profile. Orthodontic treatment did not require extraction. Crossbite was corrected by protrusion of upper teeth, which contributed to alignment and leveling of teeth, in addition to improving the patient's facial profile. The case was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO as a requirement for the BBO certification.

  13. Upper incisor to Soft Tissue Plane (UI-STP): a new reference for diagnosis and planning in dentofacial deformities.

    Science.gov (United States)

    Hernandez-Alfaro, Federico

    2010-09-01

    Planning in orthognathic surgery has been and still is an open issue. We have evolved from 2D classical cephalometric hard-tissue planning to 2D soft tissue planning, and finally to 3D and hard and soft tissue evaluation. This, to our knowledge, is the first description of a new Soft Tissue Plane (STP) and its relationship with the anterior position of the upper incisor (UI). Profile photographs of 110 "attractive individuals" with lips at rest or smiling and with upper incisor shown were used. The photographs used were of 65 professional models from two international agencies and 45 individuals considered most attractive in the internet forums, which included catwalk models and actors. In 86 cases (78.18 %), the incisor was located in front of the STP (A). In 15 cases (13.63%), it was on the plane (N); and in the remaining 9 cases (8.18%), it was behind (P). Despite the limitations of this study and based on our series, we can conclude that the upper incisor is located at or in front of the Soft Tissue Plane (STP) in 91.81% of the attractive facial profiles studied. On the other hand, the relative position of the upper incisor to the soft tissue plane (UI-STP) could be a useful diagnostic and planning tool in orthodontic and surgical management of dentofacial deformities.

  14. Upper incisor to Soft Tissue Plane (UI-STP): a new reference for diagnosis and planning in dentofacial deformities.

    Science.gov (United States)

    Hernandez-Alfaro, Federico

    2010-09-01

    Planning in orthognathic surgery has been and still is an open issue. We have evolved from 2D classical cephalometric hard-tissue planning to 2D soft tissue planning, and finally to 3D and hard and soft tissue evaluation. This, to our knowledge, is the first description of a new Soft Tissue Plane (STP) and its relationship with the anterior position of the upper incisor (UI). Profile photographs of 110 "attractive individuals" with lips at rest or smiling and with upper incisor shown were used. The photographs used were of 65 professional models from two international agencies and 45 individuals considered most attractive in the internet forums, which included catwalk models and actors. In 86 cases (78.18 %), the incisor was located in front of the STP (A). In 15 cases (13.63%), it was on the plane (N); and in the remaining 9 cases (8.18%), it was behind (P). Despite the limitations of this study and based on our series, we can conclude that the upper incisor is located at or in front of the Soft Tissue Plane (STP) in 91.81% of the attractive facial profiles studied. On the other hand, the relative position of the upper incisor to the soft tissue plane (UI-STP) could be a useful diagnostic and planning tool in orthodontic and surgical management of dentofacial deformities. PMID:20383095

  15. Postsurgical Relapse in Class III Patients Treated With Two-Jaw Surgery: Conventional Three-Stage Method Versus Surgery-First Approach.

    Science.gov (United States)

    Park, Heon-Mook; Yang, Il-Hyung; Choi, Jin-Young; Lee, Jong-Ho; Kim, Myung-Jin; Baek, Seung-Hak

    2015-11-01

    The aim of this study was to investigate the pattern, amount, and distribution of postsurgical relapse in skeletal Class III patients treated with two-jaw surgery (TJS) using conventional three-stage method (CTM) and surgery-first approach (SFA). A total of 38 patients who underwent the nonextraction approach and TJS (LeFort I posterior impaction and mandibular setback) were divided into CTM and SFA groups (all n = 19/group). Lateral cephalograms were taken before treatment (T0), at 1 month before surgery (T1), immediately after surgery (T2), and at debonding (T3) for CTM patients and at T0, T2, and T3 stages for SFA patients. Cephalometric measurements and statistical analyses were performed. There were no significant differences in the cephalometric variables at all stages except maxillary incisor inclination (U1-UOP) and overbite at T0 between 2 groups. They also did not exhibit significant differences in the amounts of surgical movement except for advancement of the maxilla. The mandible in both groups was rotated slightly clockwise by surgery and counterclockwise during T2-T3 without a significant difference. Distribution of cases with "high relapse" (>30%) and "low relapse" (<30%) of the mandible differed for 2 groups (P < 0.05). SFA group had more "high relapse" cases than CTM group (57.9% versus 26.3%). Postsurgical relapse of the mandible had a positive relationship with the amount of mandibular setback in SFA group (P < 0.01) and clockwise rotation of the proximal segment of the mandible in both groups (P < 0.05 and P < 0.01). The results suggest that SFA might be an effective alternative to CTM if the cause of "high relapse" including amounts of mandibular setback and clockwise rotation of the proximal segment of the mandible during surgery can be controlled.

  16. A method for establishing class III medical device equivalence: sodium hyaluronate (GenVisc 850) for the treatment of knee osteoarthritis.

    Science.gov (United States)

    Doros, Gheorghe; Lavin, Philip T; Daley, Michael; Miller, Larry E

    2016-01-01

    Although the concept of equivalence for drugs (generics) and biologics (biosimilars) has been readily adopted, the concept of equivalence or indistinguishable characteristics for class III medical devices has yet to be specifically addressed regarding a defined regulatory approval process in the US. In September 2015, GenVisc 850® (sodium hyaluronate), a hyaluronic acid approved for the treatment of knee osteoarthritis, was approved by the US Food and Drug Administration (FDA) based upon indistinguishable characteristics in comparison to an approved branded hyaluronic acid (Supartz®/Supartz FX™). The purpose of this paper is to review the methodology and report the main outcomes used to demonstrate clinical comparability of GenVisc 850 with Supartz/Supartz FX. The FDA approval was collectively attained using prospectively defined methods for preclinical, physical, and chemical testing, as well as noninferiority in clinical performance comparisons. Evidence from five randomized controlled studies of Supartz/Supartz FX vs saline control injections (used for Supartz approval), two randomized controlled trials of GenVisc 850 vs saline control injections, and one randomized controlled study of GenVisc 850 vs Supartz/Supartz FX provided evidence of safety for GenVisc 850. Efficacy was further assessed based on assessment of the same Supartz studies and three prospectively identified GenVisc 850 studies. A Bayesian network meta-analysis was used to demonstrate that the clinical efficacy of GenVisc 850 was noninferior to Supartz/Supartz FX and superior to saline control. Overall, safety of GenVisc 850 was similar to that of Supartz/Supartz FX and saline control injections, while efficacy of GenVisc 850 was noninferior to that of Supartz/Supartz FX and superior to saline control injections. PMID:27471412

  17. Functional and structural comparison of pyrrolnitrin- and iprodione-induced modifications in the class III histidine-kinase Bos1 of Botrytis cinerea.

    Directory of Open Access Journals (Sweden)

    Sabine Fillinger

    Full Text Available Dicarboximides and phenylpyrroles are commonly used fungicides against plant pathogenic ascomycetes. Although their effect on fungal osmosensing systems has been shown in many studies, their modes-of-action still remain unclear. Laboratory- or field-mutants of fungi resistant to either or both fungicide categories generally harbour point mutations in the sensor histidine kinase of the osmotic signal transduction cascade.In the present study we compared the mechanisms of resistance to the dicarboximide iprodione and to pyrrolnitrin, a structural analogue of phenylpyrrole fungicides, in Botrytis cinerea. Pyrrolnitrin-induced mutants and iprodione-induced mutants of B. cinerea were produced in vitro. For the pyrrolnitrin-induced mutants, a high level of resistance to pyrrolnitrin was associated with a high level of resistance to iprodione. For the iprodione-induced mutants, the high level of resistance to iprodione generated variable levels of resistance to pyrrolnitrin and phenylpyrroles. All selected mutants showed hypersensitivity to high osmolarity and regardless of their resistance levels to phenylpyrroles, they showed strongly reduced fitness parameters (sporulation, mycelial growth, aggressiveness on plants compared to the parental phenotypes. Most of the mutants presented modifications in the osmosensing class III histidine kinase affecting the HAMP domains. Site directed mutagenesis of the bos1 gene was applied to validate eight of the identified mutations. Structure modelling of the HAMP domains revealed that the replacements of hydrophobic residues within the HAMP domains generally affected their helical structure, probably abolishing signal transduction. Comparing mutant phenotypes to the HAMP structures, our study suggests that mutations perturbing helical structures of HAMP2-4 abolish signal-transduction leading to loss-of-function phenotype. The mutation of residues E529, M427, and T581, without consequences on HAMP structure

  18. Application for a Permit to Operate a Class III Solid Waste Disposal Site at the Nevada Test Site Area 5 Asbestiform Low-Level Solid Waste Disposal Site

    International Nuclear Information System (INIS)

    The NTS solid waste disposal sites must be permitted by the state of Nevada Solid Waste Management Authority (SWMA). The SWMA for the NTS is the Nevada Division of Environmental Protection, Bureau of Federal Facilities (NDEP/BFF). The U.S. Department of Energy's National Nuclear Security Administration Nevada Site Office (NNSA/NSO) as land manager (owner), and National Security Technologies (NSTec), as operator, will store, collect, process, and dispose all solid waste by means that do not create a health hazard, a public nuisance, or cause impairment of the environment. NTS disposal sites will not be included in the Nye County Solid Waste Management Plan. The NTS is located approximately 105 kilometers (km) (65 miles (mi)) northwest of Las Vegas, Nevada (Figure 1). The U.S. Department of Energy (DOE) is the federal lands management authority for the NTS, and NSTec is the Management and Operations contractor. Access on and off the NTS is tightly controlled, restricted, and guarded on a 24-hour basis. The NTS has signs posted along its entire perimeter. NSTec is the operator of all solid waste disposal sites on the NTS. The Area 5 RWMS is the location of the permitted facility for the Solid Waste Disposal Site (SWDS). The Area 5 RWMS is located near the eastern edge of the NTS (Figure 2), approximately 26 km (16 mi) north of Mercury, Nevada. The Area 5 RWMS is used for the disposal of low-level waste (LLW) and mixed low-level waste. Many areas surrounding the RWMS have been used in conducting nuclear tests. A Notice of Intent to operate the disposal site as a Class III site was submitted to the state of Nevada on January 28, 1994, and was acknowledged as being received in a letter to the NNSA/NSO on August 30, 1994. Interim approval to operate a Class III SWDS for regulated asbestiform low-level waste (ALLW) was authorized on August 12, 1996 (in letter from Paul Liebendorfer to Runore Wycoff), with operations to be conducted in accordance with the ''Management Plan

  19. Application for a Permit to Operate a Class III Solid Waste Disposal Site at the Nevada Test Site Area 5 Asbestiform Low-Level Solid Waste Disposal Site

    Energy Technology Data Exchange (ETDEWEB)

    NSTec Environmental Programs

    2010-09-14

    The NTS solid waste disposal sites must be permitted by the state of Nevada Solid Waste Management Authority (SWMA). The SWMA for the NTS is the Nevada Division of Environmental Protection, Bureau of Federal Facilities (NDEP/BFF). The U.S. Department of Energy's National Nuclear Security Administration Nevada Site Office (NNSA/NSO) as land manager (owner), and National Security Technologies (NSTec), as operator, will store, collect, process, and dispose all solid waste by means that do not create a health hazard, a public nuisance, or cause impairment of the environment. NTS disposal sites will not be included in the Nye County Solid Waste Management Plan. The NTS is located approximately 105 kilometers (km) (65 miles [mi]) northwest of Las Vegas, Nevada (Figure 1). The U.S. Department of Energy (DOE) is the federal lands management authority for the NTS, and NSTec is the Management and Operations contractor. Access on and off the NTS is tightly controlled, restricted, and guarded on a 24-hour basis. The NTS has signs posted along its entire perimeter. NSTec is the operator of all solid waste disposal sites on the NTS. The Area 5 RWMS is the location of the permitted facility for the Solid Waste Disposal Site (SWDS). The Area 5 RWMS is located near the eastern edge of the NTS (Figure 2), approximately 26 km (16 mi) north of Mercury, Nevada. The Area 5 RWMS is used for the disposal of low-level waste (LLW) and mixed low-level waste. Many areas surrounding the RWMS have been used in conducting nuclear tests. A Notice of Intent to operate the disposal site as a Class III site was submitted to the state of Nevada on January 28, 1994, and was acknowledged as being received in a letter to the NNSA/NSO on August 30, 1994. Interim approval to operate a Class III SWDS for regulated asbestiform low-level waste (ALLW) was authorized on August 12, 1996 (in letter from Paul Liebendorfer to Runore Wycoff), with operations to be conducted in accordance with the &apos

  20. 骨性错(牙合)患者颌面部美观的自我评价%Self-evaluation of dentofacial esthetics in skeletal malocclusion patients

    Institute of Scientific and Technical Information of China (English)

    孙伟; 侯敏; 王建国

    2013-01-01

    ) and prominence of their teeth (17.8 %) were the most frequent causes of concern.Older subjects,women,and skeletal malocclusion patients were less happy with their facial appearance.Most of them were dissatisfied with the facial appearance focused on the chin (53 %),facial contours (37 %),and the position of the teeth when smiling (33 %).A greater proportion of Class Ⅲ subjects than Class Ⅱ subjects wished to change their appearance.Conclusions The findings indicate that women and skeletal malocclusion patients have lower levels of happiness with their dentofacial appearance.Although Class Ⅱ patients exhibit the lowest levels of happiness with their dental appearance,there is some evidence that concerns and awareness about their facial profile are more pronounced among the Class Ⅲ patients.

  1. Assessment of the epidemiological profile of patients with dentofacial deformities who underwent orthognathic surgery.

    Science.gov (United States)

    Castro, Vanessa; do Prado, Celio Jesus; Neto, Antonio Irineu Trindade; Zanetta-Barbosa, Darceny

    2013-05-01

    The present study aimed to establish the profile of patients who underwent orthognathic surgery in a private clinic by evaluating their demographic characteristics, their facial types, and aspects related to the surgical procedures that were performed. The sample consisted of 419 medical records from male and female patients aged 15 to 62 years who underwent orthognathic surgery between 2001 and 2011. A single examiner collected data by evaluating a database of information extracted from medical records, particularly radiographic and photographic analyses. The following criteria were evaluated: gender, age, skin color, type of orthognathic surgery, type of associated temporomandibular joint (TMJ) surgery, complications, and recurrences. Seventeen patients were rejected because they had incomplete records. The average age of the patients was 28.5 years old; most were females (255 patients) and faioderm (295 patients). The most prevalent facial pattern was Pattern III (n = 166, 41.3%). Orthognathic surgery that affected the maxilla, jaw, and chin was the most prevalent type (n = 199, 49.5% of cases). A genioplasty was performed concurrently with combined surgeries and single-jaw surgery in 76.86% of patients (n = 309). TMJ surgery was performed concomitantly with orthognathic surgery in 4% of cases (n = 16). The most common postoperative complication was infection/inflammation (n = 12). We concluded that there was a higher frequency of orthognathic surgery among women and young people, the brunette skin phenotype was prevalent, and most patients had a combination of maxillary and mandibular problems.

  2. A New View of Alcohol Metabolism and Alcoholism—Role of the High-Km Class III Alcohol Dehydrogenase (ADH3)

    Science.gov (United States)

    Haseba, Takeshi; Ohno, Youkichi

    2010-01-01

    The conventional view is that alcohol metabolism is carried out by ADH1 (Class I) in the liver. However, it has been suggested that another pathway plays an important role in alcohol metabolism, especially when the level of blood ethanol is high or when drinking is chronic. Over the past three decades, vigorous attempts to identify the enzyme responsible for the non-ADH1 pathway have focused on the microsomal ethanol oxidizing system (MEOS) and catalase, but have failed to clarify their roles in systemic alcohol metabolism. Recently, using ADH3-null mutant mice, we demonstrated that ADH3 (Class III), which has a high Km and is a ubiquitous enzyme of ancient origin, contributes to systemic alcohol metabolism in a dose-dependent manner, thereby diminishing acute alcohol intoxication. Although the activity of ADH3 toward ethanol is usually low in vitro due to its very high Km, the catalytic efficiency (kcat/Km) is markedly enhanced when the solution hydrophobicity of the reaction medium increases. Activation of ADH3 by increasing hydrophobicity should also occur in liver cells; a cytoplasmic solution of mouse liver cells was shown to be much more hydrophobic than a buffer solution when using Nile red as a hydrophobicity probe. When various doses of ethanol are administered to mice, liver ADH3 activity is dynamically regulated through induction or kinetic activation, while ADH1 activity is markedly lower at high doses (3–5 g/kg). These data suggest that ADH3 plays a dynamic role in alcohol metabolism, either collaborating with ADH1 or compensating for the reduced role of ADH1. A complex two-ADH model that ascribes total liver ADH activity to both ADH1 and ADH3 explains the dose-dependent changes in the pharmacokinetic parameters (β, CLT, AUC) of blood ethanol very well, suggesting that alcohol metabolism in mice is primarily governed by these two ADHs. In patients with alcoholic liver disease, liver ADH3 activity increases, while ADH1 activity decreases, as alcohol

  3. Estudo cefalométrico das alterações no perfil facial em pacientes Classe III dolicocefálicos submetidos à cirurgia ortognática bimaxilar Cephalometric study of the facial profile changes in Class III patients submitted to bimaxillary orthognathic surgery

    Directory of Open Access Journals (Sweden)

    Hewerson Santos Tavares

    2005-10-01

    Full Text Available O presente estudo avaliou as modificações no perfil facial de 15 pacientes portadores de má oclusão Classe III esquelética que foram submetidos a tratamento ortodôntico pré-cirúrgico e cirurgia ortognática bimaxilar estabilizada com fixação rígida. Oito pacientes foram submetidos à mentoplastia. Foram utilizadas telerradiografias pré-cirúrgicas (T1 e pós-cirúrgicas (T2 com um intervalo mínimo de 6 meses. Foram analisados deslocamentos horizontais e verticais em pontos do tecido ósseo e tecido mole. Foi realizada uma comparação entre os casos tratados com e sem mentoplastia (teste t mostrando não haver diferenças entre os grupos. A regressão linear múltipla evidenciou uma correlação significante no sentido horizontal para os pontos Pg e Pgm e vertical para os pontos Me e Mem. Foi encontrada baixa correlação para movimentos no sentido horizontal nos pontos Sena e A, e para os pontos Pn, Sn e Ph. No sentido vertical, os deslocamentos mais evidentes foram entre os pontos Pg, Gn e Me e Sena e A, porém com correlações de baixa intensidade.The present study evaluated the facial profile modifications in 15 skeletal Class III patients that were submitted to presurgical orthodontic treatment and orthognathic bimaxillary surgery stabilized with a rigid fixation. Eight of the patients have undergone to genioplastic surgery. Presurgical (T1 and late postsurgical (T2 radiographs taken apart with a minimum of 6 month interval had been used. The horizontal and vertical displacement of skeletal and soft tissue profile points were analyzed. The comparison of the cases submitted or not to a genioplastic surgery (t Test showed no differences for the displacement of the skeletal and soft tissue points. The multiple linear regression analysis showed a significant correlation for horizontal movements of the Pg and Pgm points and for vertical movements of the Me and Mem points. A low correlation was found for the horizontal movements of

  4. The effects, limitations, and long-term dentofacial adaptations to treatment with the Herbst appliance.

    Science.gov (United States)

    Pancherz, H

    1997-12-01

    The purpose of this article is to summarize the existing scientific data with respect to the short- and long-term effects of the Herbst appliance on the occlusion and on the maxillo/mandibular complex. The article also discusses the treatment indications and possible treatment limitations. The Herbst method is most effective in the treatment of Class II malocclusions. Long-term stability seems to be dependent on a stable cuspal interdigitation. Marked mandibular morphological changes occur during therapy and sagittal condylar growth is increased. Posttreatment, most of the mandibular morphological changes revert and no long-term influence of Herbst treatment on mandibular growth can be verified. The appliance effect on the maxillary complex can be compared with that of a high-pull headgear. Without proper retention, however, this effect is of a temporary nature. Herbst treatment is especially indicated in the permanent dentition at or just after the pubertal peak of growth. Mixed dentition treatment is not recommended, as a stable cuspal interdigitation after therapy is difficult to achieve and relapses are prone to occur. In the nongrowing patient, the appliance should be used with great caution.

  5. Associação entre doença hepática gordurosa não alcoólica e marcadores de lesão/função hepática com componentes da síndrome metabólica em indivíduos obesos classe III Association between non-alcoholic fatty liver disease and liver function/injury markers with metabolic syndrome components in class III obese individuals

    Directory of Open Access Journals (Sweden)

    Gabriela Villaça Chaves

    2012-06-01

    Full Text Available OBJETIVO: Investigar a associação entre doença hepática gordurosa não alcoólica (DHGNA e os marcadores de lesão e função hepática com os componentes da síndrome metabólica (SM em indivíduos obesos classe III. MÉTODOS: A população estudada foi constituída por 144 pacientes com obesidade classe III (IMC > a 40 kg/m². A SM foi identificada segundo o critério do NCEP ATP III, por meio da determinação do perfil lipídico, glicemia e insulina basal. Foram quantificados ainda os marcadores de função e lesão hepática. A resistência à insulina (RI foi verificada pelo índice HOMA-IR e o diagnóstico da DHGNA por ressonância magnética. Os cálculos estatísticos foram realizados pelo programa estatístico SPSS na versão 13.0. A associação foi verificada pelo teste Mann-Whitney e qui-quadrado, com nível de significância de 5%. RESULTADOS: Foi encontrada associação significativa entre o diagnóstico de SM e DHGNA (χ² = 6,84; p = 0,01. Quanto aos componentes diagnósticos para SM, constatou-se associação positiva e significativa entre HDL-c (p = 0,05, circunferência da cintura (p OBJECTIVE: To investigate the association between non-alcoholic fatty liver disease (NAFLD and liver function/injury markers with components of metabolic syndrome (MS in class III obese individuals. METHODS: The study population consisted of 144 patients with class III obesity (body mass index [BMI] > 40 kg/m². MS was diagnosed according to the National Cholesterol Education Program - Adult Treatment Panel III (NCEP ATP III criteria, by determining the lipid profile, blood glucose and basal insulin. Liver function/injury markers were also quantified. Insulin resistance (IR was measured by HOMA-IR and NAFLD diagnosis was established by magnetic resonance imaging (MRI. Statistical calculations were performed by SPSS version 13.0. The association was assessed by the Mann-Whitney and Chi-square tests, with a level of significance set at 5

  6. Treating dental crowding with mandibular incisor extraction in an Angle Class I patient

    Directory of Open Access Journals (Sweden)

    Gislana Braga Machado

    2015-06-01

    Full Text Available Mandibular dental crowding often encourages patients to seek orthodontic treatment. The orthodontist should decide between protrusion of incisors or decrease in dental volume so as to achieve proper alignment and leveling. The present study reports the treatment of an Angle Class I malocclusion adolescent female brachyfacial patient with severe mandibular dental crowding, increased curve of Spee and deep overbite. The patient was treated with extraction of a mandibular incisor. This case was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO as a requirement for the title of certified by the BBO.

  7. Treating dental crowding with mandibular incisor extraction in an Angle Class I patient.

    Science.gov (United States)

    Machado, Gislana Braga

    2015-01-01

    Mandibular dental crowding often encourages patients to seek orthodontic treatment. The orthodontist should decide between protrusion of incisors or decrease in dental volume so as to achieve proper alignment and leveling. The present study reports the treatment of an Angle Class I malocclusion adolescent female brachyfacial patient with severe mandibular dental crowding, increased curve of Spee and deep overbite. The patient was treated with extraction of a mandibular incisor. This case was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO) as a requirement for the title of certified by the BBO. PMID:26154463

  8. The novel pterostilbene derivative ANK-199 induces autophagic cell death through regulating PI3 kinase class III/beclin 1/Atg‑related proteins in cisplatin‑resistant CAR human oral cancer cells.

    Science.gov (United States)

    Hsieh, Min-Tsang; Chen, Hao-Ping; Lu, Chi-Cheng; Chiang, Jo-Hua; Wu, Tian-Shung; Kuo, Daih-Huang; Huang, Li-Jiau; Kuo, Sheng-Chu; Yang, Jai-Sing

    2014-08-01

    Pterostilbene is an effective chemopreventive agent against multiple types of cancer cells. A novel pterostilbene derivative, ANK-199, was designed and synthesized by our group. Its antitumor activity and mechanism in cisplatin-resistant CAR human oral cancer cells were investigated in this study. Our results show that ANK-199 has an extremely low toxicity in normal oral cell lines. The formation of autophagic vacuoles and acidic vesicular organelles (AVOs) was observed in the ANK-199-treated CAR cells by monodansylcadaverine (MDC) and acridine orange (AO) staining, suggesting that ANK-199 is able to induce autophagic cell death in CAR cells. Neither DNA fragmentation nor DNA condensation was observed, which means that ANK-199-induced cell death is not triggered by apoptosis. In accordance with morphological observation, 3-MA, a specific inhibitor of PI3K kinase class III, can inhibit the autophagic vesicle formation induced by ANK-199. In addition, ANK-199 is also able to enhance the protein levels of autophagic proteins, Atg complex, beclin 1, PI3K class III and LC3-II, and mRNA expression of autophagic genes Atg7, Atg12, beclin 1 and LC3-II in the ANK-199-treated CAR cells. A molecular signaling pathway induced by ANK-199 was therefore summarized. Results presented in this study show that ANK-199 may become a novel therapeutic reagent for the treatment of oral cancer in the near future (patent pending).

  9. "Converting a bi-jaw surgery to a single-jaw surgery:" Posterior maxillary dentoalveolar intrusion with microimplants to avoid the need of a maxillary surgery in the surgical management of skeletal Class III vertical malocclusion

    Directory of Open Access Journals (Sweden)

    Abhisek Ghosh

    2016-01-01

    Full Text Available The management of a vertical skeletal Class III malocclusion with mandibular prognathism revolves around the protocol of bi-jaw surgery (maxillary LeFort I impaction and mandibular bilateral sagittal split osteotomy with setback. The maxillary surgery not only provides increased stability to the ultimate surgical outcome but also increases the amount by which the mandibular set back can be done, therefore aiding in greater profile improvement. With the need of maxillary surgery almost inevitable in treating such situations, the complexity and the increased discomfort associated with such surgery can never be ignored. Is it at all possible to convert a bi-jaw surgery into a single-jaw surgery with the aid of microimplants? With increasing number of patients being treated with microimplants for anterior openbite and gummy smiles, our idea was to incorporate this novel protocol in treating Class III vertical situations and therefore avoid the need of a maxillary surgery in treating such a situation, together with achieving optimum treatment outcome.

  10. Angle Class II malocclusion treated with extraction of permanent teeth

    Directory of Open Access Journals (Sweden)

    Gustavo Mattos Barreto

    2013-08-01

    Full Text Available Angle Class II malocclusion associated with anterior open bite in adult patients demands a carefully elaborated orthodontic planning, aiming at restoring not only harmonious dental and facial esthetics, but also a balanced masticatory function. Orthognathic surgery or permanent teeth extraction are often the choice of treatment, therefore, treatment decision is related to all dental, skeletal and functional aspects. The present report discusses orthodontic compensation carried out by means of upper premolar extraction performed to correct the Class II canine relationship and, consequently, the anterior open bite, accepting that the upper incisors be retroclined. This clinical case was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO as part of the requirements for obtaining the BBO Certification.

  11. Class III antiarrhythmic agents in cardiac failure: lessons from clinical trials with a focus on the Grupo de Estudio de la Sobrevida en la Insuficiencia Cardiaca en Argentina (GESICA).

    Science.gov (United States)

    Doval, H C

    1999-11-01

    The results of previous clinical trials, in a variety of clinical settings, showed that class I agents may consistently increase mortality in sharp contrast to the effects of beta blockers. Attention has therefore shifted to class III compounds for potential beneficial effects on long-term mortality among patients with underlying cardiac disease. Clinical trials with d-sotalol, the dextro isomer (devoid of beta blockade) of sotalol, showed increased mortality in patients with low ejection fraction after myocardial infarction and in those with heart failure; whereas in the case of dofetilide, the impact on mortality was neutral. Because of the complex effects of its actions as an alpha-adrenergic blocker and a class III agent, the impact on mortality of amiodarone in patients with heart failure is of particular interest. A meta-analysis of 13 clinical trials revealed significant reductions in all-cause and cardiac mortality among patients with heart failure or previous myocardial infarction. Among these were 5 controlled clinical trials that investigated the effects of amiodarone on mortality among patients with heart failure. None of these trials was large relative to the beta-blocker trials in the postinfarction patients. However, the larger 2 of the 5 amiodarone trials produced discordant effects on mortality, neutral in one and significantly positive in the other. Some of the differences may be accounted for by the differences in eligibility criteria and baseline characteristics. Future trials that may be undertaken to resolve the discrepancies may need to allow for the newer findings on the effects of concomitant beta blockers, implantable devices, and possibly, spironolactone. All these modalities of treatment have been shown in controlled clinical trials to augment survival in patients with impaired ventricular function or manifest heart failure. Additional trials, some of which are currently in progress, compare amiodarone with implantable devices and other

  12. Class II malocclusion occlusal severity description

    Directory of Open Access Journals (Sweden)

    Guilherme Janson

    2010-08-01

    Full Text Available OBJECTIVES: It is well known that the efficacy and the efficiency of a Class II malocclusion treatment are aspects closely related to the severity of the dental anteroposterior discrepancy. Even though, sample selection based on cephalometric variables without considering the severity of the occlusal anteroposterior discrepancy is still common in current papers. In some of them, when occlusal parameters are chosen, the severity is often neglected. The purpose of this study is to verify the importance given to the classification of Class II malocclusion, based on the criteria used for sample selection in a great number of papers published in the orthodontic journal with the highest impact factor. MATERIAL AND METHODS: A search was performed in PubMed database for full-text research papers referencing Class II malocclusion in the history of the American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO. RESULTS: A total of 359 papers were retrieved, among which only 72 (20.06% papers described the occlusal severity of the Class II malocclusion sample. In the other 287 (79.94% papers that did not specify the anteroposterior discrepancy severity, description was considered to be crucial in 159 (55.40% of them. CONCLUSIONS: Omission in describing the occlusal severity demands a cautious interpretation of 44.29% of the papers retrieved in this study.

  13. Relação entre o estado nutricional de vitamina a e a regressão da esteatose hepática após gastroplastia em Y- de- Roux para tratamento da obesidade classe III Relationship of the nutritional status of vitamin a and the regression of hepatic steatosis after Roux-en-Y gastric bypass surgery for treatment of class III obesity

    Directory of Open Access Journals (Sweden)

    Luiz Gustavo de Oliveira e Silva

    2012-12-01

    Full Text Available RACIONAL: A vitamina A participa de várias funções primordiais no organismo humano e as suas concentrações séricas podem estar diminuídas nas doenças crônicas não transmissíveis. OBJETIVO: Avaliar a relação entre o estado nutricional da vitamina A, e a regressão da esteatose hepática em indivíduos submetidos à gastroplastia em Y-de-Roux para tratamento da obesidade classe III. MÉTODOS: Foram estudados 30 pacientes obesos classe III, de ambos os sexos, com esteatose hepática, submetidos à gastroplastia em Y-de-Roux. Seis meses após a operação, os pacientes foram submetidos à ultrassonografia abdominal e distribuídos em dois grupos: grupo 1 - pacientes com esteatose detectada na ultrassonografia e grupo 2 - pacientes sem esteatose detectada na ultrassonografia. No pré-operatório e seis meses após a operação foram realizadas análises antropométricas e exames bioquímicos: insulina basal, glicemia, Homeostasis Model Assessment Index (HOMA IR, colesterol, HDL, LDL, triglicerídeos, AST, ALT, Gama-GT, albumina, bilirrubina total, retinol, e beta caroteno. RESULTADOS: A média de perda de peso foi de 35,05 + 10,47 (pBACKGROUND: Vitamin A participates in several essentials functions in the human body and their serum concentrations may be decreased in non-transmissible diseases. AIM: To assess the relationship of the nutritional status of Vitamin A through the serum concentrations of retinol and beta carotene, with regression of hepatic steatosis in individuals who undergone Roux-en-Y gastric bypass surgery for treatment of class III obesity. METHODS: Were included 30 individuals, male and female, submitted to Roux-en-Y gastric bypass for treatment of class III obesity, who were diagnosed through an abdominal ultrasonography as presenting hepatic steatosis. From the result of an ultrasonography screened six months after the surgical procedure those subjects were divided into two groups: group 1 - patients with steatosis

  14. Transient analyses of the 400MWth-class EFIT accelerator driven transmuter with the multi-physics code: SIMMER-III

    Energy Technology Data Exchange (ETDEWEB)

    Liu Ping, E-mail: ping.liu@areva.co [Karlsruhe Institute of Technology (KIT), Institute for Nuclear and Energy Technologies (IKET), P. O. Box 3640, D-76021 Karlsruhe (Germany); Chen Xuenong; Rineiski, Andrei; Maschek, Werner [Karlsruhe Institute of Technology (KIT), Institute for Nuclear and Energy Technologies (IKET), P. O. Box 3640, D-76021 Karlsruhe (Germany)

    2010-10-15

    In the EUROTRANS Programme of the 6th FP of the EC, EFIT, the European Facility for Industrial Transmutation, a generic conceptual design of a 400MWth ADS transmuter loaded with a CERCER U-free fuel with an MgO matrix, is developed. The safety objectives for the EFIT are achieved on the basis of the defense-in-depth concept. For the safety assessment various protected and unprotected design basis conditions (DBC) and design extension conditions (DEC) transients have been analyzed as e.g. the protected and unprotected loss of flow (PLOF/ULOF), beam trip transients, over power transients and especially the unprotected blockage accidents (UBAs). Key safety analyses of the EFIT core have been performed with the SIMMER-III code, currently the only code which can handle core disruptive conditions for heavy liquid metal cooled reactors. Unprotected transients set upper safety limits and play an important role in the overall safety assessment and transient behaviors of an ADS with MgO based fuel and T91 cladding. The high temperature range is still affected by significant uncertainties, therefore, unprotected accidents with a potential of fuel failure and fission gas release deserve special attention. In this paper, analyses of important and challenging transient cases will be presented. The SIMMER-III simulated results indicate that under the current conditions, the EFIT core can survive in most of the transient cases without pin failure except in the UBA cases. The analyses thus demonstrate the general high safety potential of an ADS like EFIT. Results of the UBA cases show that pin failure happens in the core center and propagation of the pin failure could be possible, while the core will finally arrive at a lower power condition because of the sweeping out of the fuel from the active core.

  15. Sinus lifting before Le Fort I maxillary osteotomy: a suitable method for oral rehabilitation of edentulous patients with skelettal class-III conditions: review of the literature and report of a case

    Directory of Open Access Journals (Sweden)

    Meyer Ulrich

    2007-01-01

    Full Text Available Abstract Background Functional rehabilitation of patients afflicted with severe mandibular and maxillary alveolar atrophy might be challenging especially in malformed patients. Methods Treatment planning using sinus lifting and implant placement before Le Fort I maxillary osteotomy in a patient with severe mandibular and posterior maxillary alveolar atrophy and skelettal class-III conditions due to cleft palate are described. Results A full functional and esthetic rehabilitation of the patient was achieved by a stepwise surgical approach performed through sinus lifting as the primary approach followed by implant placement and subsequent Le Fort I maxillary osteotomy to correct the maxillo-mandibular relation. Conclusion Stabilisation of the maxillary complex by a sinus lifting procedure in combination with computer aided implant placement as preorthodontic planning procedure before Le Fort I maxillary osteotomy seems to be suitable in order to allow ideal oral rehabilitation especially in malformed patients.

  16. Application of advanced reservoir characterization, simulation, and production optimization strategies to maximize recovery in slope and basin clastic reservoirs, West Texas (Delaware Basin), Class III

    Energy Technology Data Exchange (ETDEWEB)

    Dutton, Shirley P.; Flanders, William A.; Zirczy, Helena H.

    2000-05-24

    The objective of this Class 3 project was to demonstrate that detailed reservoir characterization of slope and basin clastic reservoirs in sandstones of the Delaware Mountain Group in the Delaware Basin of West Texas and New Mexico is a cost effective way to recover a higher percentage of the original oil in place through strategic placement of infill wells and geologically based field development. Phase 1 of the project, reservoir characterization, was completed this year, and Phase 2 began. The project is focused on East Ford field, a representative Delaware Mountain Group field that produces from the upper Bell Canyon Formation (Ramsey sandstone). The field, discovered in 1960, is operated by Oral Petco, Inc., as the East Ford unit. A CO{sub 2} flood is being conducted in the unit, and this flood is the Phase 2 demonstration for the project.

  17. A Determination of H_0 with the CLASS Gravitational Lens B1608+656 III. A Significant Improvement in the Precision of the Time Delay Measurements

    CERN Document Server

    Fassnacht, C D; Koopmans, L V E; Rusin, D

    2002-01-01

    The gravitational lens CLASS B1608+656 is the only four-image lens system for which all three independent time delays have been measured. This makes the system an excellent candidate for a high-quality determination of H_0 at cosmological distances. However, the original measurements of the time delays had large (12-20%) uncertainties, due to the low level of variability of the background source during the monitoring campaign. In this paper, we present results from two additional VLA monitoring campaigns. In contrast to the ~5% variations seen during the first season of monitoring, the source flux density changed by 25-30% in each of the subsequent two seasons. We analyzed the combined data set from all three seasons of monitoring to improve significantly the precision of the time delay measurements; the delays are consistent with those found in the original measurements, but the uncertainties have decreased by factors of two to three. We combined the delays with revised isothermal mass models to derive a mea...

  18. Mycobacterium tuberculosis class II apurinic/apyrimidinic-endonuclease/3'-5' exonuclease III exhibits DNA regulated modes of interaction with the sliding DNA β-clamp.

    Science.gov (United States)

    Khanam, Taran; Rai, Niyati; Ramachandran, Ravishankar

    2015-10-01

    The class-II AP-endonuclease (XthA) acts on abasic sites of damaged DNA in bacterial base excision repair. We identified that the sliding DNA β-clamp forms in vivo and in vitro complexes with XthA in Mycobacterium tuberculosis. A novel 239 QLRFPKK245 motif in the DNA-binding domain of XthA was found to be important for the interactions. Likewise, the peptide binding-groove (PBG) and the C-terminal of β-clamp located on different domains interact with XthA. The β-clamp-XthA complex can be disrupted by clamp binding peptides and also by a specific bacterial clamp inhibitor that binds at the PBG. We also identified that β-clamp stimulates the activities of XthA primarily by increasing its affinity for the substrate and its processivity. Additionally, loading of the β-clamp onto DNA is required for activity stimulation. A reduction in XthA activity stimulation was observed in the presence of β-clamp binding peptides supporting that direct interactions between the proteins are necessary to cause stimulation. Finally, we found that in the absence of DNA, the PBG located on the second domain of the β-clamp is important for interactions with XthA, while the C-terminal domain predominantly mediates functional interactions in the substrate's presence.

  19. Investigation of Class I, II and III Integrons among Acinetobacter Strains Isolated from Ventilator-Associated Pneumonia Patients in Intensive Care Unit of Rasoul Akram Hospital in Tehran, Iran

    Directory of Open Access Journals (Sweden)

    Hajar Mohammadi-Barzelighi

    2015-10-01

    Full Text Available Background: Multi-drug resistant strains of Acinetobacter spp. have created therapeutic problems worldwide. The objective of this study was to detect integrons  in Acinetobacter  spp. isolates  from Ventilator-Associated  Pneu- monia patients using PCR method.Methods: A total 51 Bronchoalveolar lavage samples were obtained from pa-tients in ICU and examined for Acinetobacter spp. infection by biochemical and PCR methods using blaOXA51-like primers. Antimicrobial susceptibility testing was performed using disk diffusion and MIC methods.Results: Among 51 patients with VAP (62.7% males, 35.2% females, mean age 53 year, 50 (98% were positive, with a high prevalence of gram-nega- tive bacteria, mainly Acinetobacter spp. (70%, from which A. baumani was detected in 34 (68% and A. lwoffii in 1 (2% of isolates. More than 90% of isolates were resistant to imipenem,  piperacillin+tazobactam,  third genera- tion cephalosporins and gentamicin, while the most effective antibiotic was colistin (100%. The correlation coefficient between disk diffusion and MIC was 0.808 (p = 0.001. Three Acinetobacter isolates (8% harbored integrase I gene but none of isolates contained Class II or III integrons.Conclusion: The results showed that colistin was an effective antibiotic andcan be used for treatment  of patients in ICU. Due to the high number of MDR isolates lacking Integrons it can be concluded that although class I in- tegrons are important among clinical isolates of A. baumannii, they have no significant  role  in  dissemination  of  antibiotic  resistance  genes  in  Rasoul Akram  Hospital in Tehran, Iran. The presence of IntI in A. lwoffii may be related to transfer of integron to A. baumannii which can be considered as an important threat for hospitalized patients.

  20. Root growth restraint can be an acclimatory response to low pH and is associated with reduced cell mortality: a possible role of class III peroxidases and NADPH oxidases.

    Science.gov (United States)

    Graças, J P; Ruiz-Romero, R; Figueiredo, L D; Mattiello, L; Peres, L E P; Vitorello, V A

    2016-07-01

    Low pH (Solanum lycopersicum cv Micro-Tom) roots were exposed directly or gradually to low pH through step-wise changes in pH over periods ranging from 4 to 24 h. Roots exposed gradually to pH 4.5 grew even less than those exposed directly, indicating a plant-coordinated response. Direct exposure to pH 4.0 suppressed root growth and caused high cell mortality, in contrast to roots exposed gradually, in which growth remained inhibited but cell viability was maintained. Total class III peroxidase activity increased significantly in all low pH treatments, but was not correlated with the observed differential responses. Use of the enzyme inhibitors salicylhydroxamic acid (SHAM) or diphenyleneiodonium chloride (DPI) suggest that peroxidase and, to a lesser extent, NADPH oxidase were required to prevent or reduce injury in all low pH treatments. However, a role for other enzymes, such as the alternative oxidase is also possible. The results with SHAM, but not DPI, were confirmed in tobacco BY-2 cells. Our results indicate that root growth inhibition from low pH can be part of an active plant response, and suggest that peroxidases may have a critical early role in reducing loss of cell viability and in the observed root growth constraint. PMID:26891589

  1. 正颌联合术后正畸矫治唇腭裂术后的牙颌面畸形%Orthognathic Surgery and Postsurgical Orthodontics for Correction of Secondary Dentofacial Deformities in Cleft Lip and Palate Patients

    Institute of Scientific and Technical Information of China (English)

    孙晓梅; 滕利; 丁波; 归来

    2012-01-01

    目的 探讨应用正颌手术联合术后正畸矫治唇腭裂术后牙颌面畸形的方法.方法 2002年1月至2010年8月,共收治25例唇腭裂术后颌骨畸形患者.男11例,女14例;年龄16~33岁;单侧唇腭裂19例,双侧6例.所有患者术前均未接受过正畸治疗.本组患者均联合应用正颌手术和术后正畸建(牙合)矫治唇腭裂术后颌骨畸形.结果 25例患者经过3~12个月的术后正畸治疗,均建立了良好的咬(牙合)关系,恢复正常咬合功能.随访6个月至3年,术后疗效稳定.结论 唇腭裂术后颌骨畸形采用正颌手术联合术后正畸能够有效矫治牙颌面畸形.%Objective To investigate an effective method of orthognathic surgery and postsurgical orthodontics for correction of secondary dentofacial deformities in cleft lip and palate patients. Methods From January 2002 to August 2010, 25 cleft patients suffering from secondary dentofacial deformities were treated. There were 11 males and 14 females, aged from 16 to 33 years (mean age: 22 years), 19 patients were unilateral cleft and 6 were bilateral cleft. All patients had not received presurgical orthodontics and were treated by orthognathic surgery accompanied with postsurgical orthodontics for deformities correction. Results All 25 patients were satisfied with their appearances and dental articulation after operation. All patients got the normal occlusion and the satisfactory intermaxillary relationship with orthodontics treatment of 3-12 months. After a follow up of 6 months to 3 years,the results of the treatment were stable. Conclusion The orthognathic surgery and postsurgical orthodontics is efficient for correction of secondary dentofacial deformities in cleft patients.

  2. Agenesis of maxillary lateral incisor in an Angle Class II, Division 1 malocclusion patient

    Directory of Open Access Journals (Sweden)

    Guilherme Thiesen

    2015-10-01

    Full Text Available The present case report describes the orthodontic treatment of a patient with agenesis of maxillary left lateral incisor and Angle Class II, Division 1 malocclusion. The patient also presented with maxillary midline deviation and inclination of the occlusal plane in the anterior region. Treatment objectives were: correction of sagittal relationship between the maxilla and the mandible; correction of midline deviation, so as to cause maxillary and mandibular midlines to coincide; correction of overbite and leveling of the occlusal plane, so as to create ideal conditions for esthetic rehabilitation of anterior teeth. This case was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO as a requirement for the title of certified by the BBO.

  3. Fermilab III

    International Nuclear Information System (INIS)

    The total ongoing plans for Fermilab are wrapped up in the Fermilab III scheme, centrepiece of which is the proposal for a new Main Injector. The Laboratory has been awarded a $200,000 Illinois grant which will be used to initiate environmental assessment and engineering design of the Main Injector, while a state review panel recommended that the project should also benefit from $2 million of funding

  4. The application of distraction osteogenesis in the temporomandibular joint ankylosis and secondary dentofacial deformities%牵张成骨在颞下颌关节强直及其继发畸形矫治中的应用

    Institute of Scientific and Technical Information of China (English)

    祝颂松; 胡静

    2016-01-01

    Temporomandibular joint ( TMJ) ankylosis is a joint disorder which refers to bone or fibrous adhesion of the anatomic joint components and the ensuing loss of function. When it occurs in children, it can cause secondary dentofa-cial deformities with physical and psychological disability. Correction of TMJ ankylosis and secondary deformities remains a great challenge for oral and maxillofacial surgeons. Distraction osteogenesis ( DO) has been used for the treatment of TMJ ankylosis and secondary deformities with satisfactory outcomes. An average of 50-60 patients with TMJ ankylosis is referred to our department annually. In this review, we summarized the characteristics of DO and discussed some factors involved in the treatment of TMJ ankylosis with dentofacial deformities.%儿童时期发生的颞下颌关节强直可以导致不同程度的颌面部骨骼发育障碍,并引起自卑、社交障碍等一系列心理问题,其矫治是口腔颌面外科医生面临的一大挑战. 牵张成骨( distraction osteogenesis,DO)一直被国内外学者用于颞下颌关节(temporomandibular joint,TMJ)强直及其继发畸形的矫治,并取得了良好的临床效果.笔者所在科室每年大概收治50~60例TMJ强直患者,对DO技术在TMJ强直及其继发畸形矫治中的应用积累了较为丰富的临床经验. 本文中,笔者对DO技术在TMJ强直及其继发畸形矫治中的优缺点及相关问题进行述评.

  5. Alcohol dehydrogenase (ADH) isozymes in the Adh{sup N}/Adh{sup N} strain of Peromyscus maniculatus (ADH{sup {minus}}deermouse) and a possible role of Class III ADH in alcohol metabolism

    Energy Technology Data Exchange (ETDEWEB)

    Haseba, Takeshi; Yamamoto, Isao; Kamii, Hajime [Nippon Medical School, Tokyo (Japan)] [and others

    1995-10-01

    Deermouse ADH isozymes have been investigated recently using cDNA probes; these studies have revealed the deletion of the Adh-1 gene for Class I ADH in the ADH{sup {minus}} strain but the presence of the Adh-2 gene encoding a possible new class of ADH in both ADH{sup {minus}} and ADH{sup +} strains. However, this potential class of ADH has not been identified as an electrophoretic phenotype, although its mRNA has been found exclusively in the liver of both strains. Furthermore, deermouse ADH isozymes other than Class I have not been systematically studied at a class level. In the present study, we thoroughly investigated the ADH systems in deermouse using hexanol as a substrate, in addition to ethanol, to detect all classes of ADH. The classes of ADH in the liver and stomach were compared between the two strains by a kinetic study and electrophoretic analysis on the basis of substrate specificity, pyrazole sensitivity, and immunoreactivity. Furthermore, we compared the liver and stomach ADH activities of deermouse with those of the ddY mouse strain and we discuss the possible roles of ADH isozymes other than Class I in alcohol metabolism of the ADH{sup {minus}} strain. 37 refs., 4 figs., 1 tab.

  6. Posição habitual de língua e padrão de deglutição em indivíduo com oclusão classe III, pré e pós-cirurgia ortognática Tongue's rest position and deglutition standards in a patient with malocclusion Class III, pre and post orthognathic surgery

    Directory of Open Access Journals (Sweden)

    Cássia Sígolo

    2009-06-01

    Full Text Available TEMA: os distúrbios miofuncionais orofaciais dos indivíduos que apresentam desproporções maxilomandibulares podem estar relacionados à condição muscular orofacial e às diferentes funções por elas realizadas. PROCEDIMENTOS: a paciente realizou um exame radiográfico de videofluoroscopia no qual se observou quantas deglutições foram necessárias para total limpeza das valéculas e qual foi a posição da língua após a deglutição de saliva. O exame foi realizado com bário líquido e pão de queijo. RESULTADOS: na avaliação pré-operatória, foi encontrada a língua posicionada no soalho da cavidade oral; mastigação com movimento compensatório de língua, com amassamento do alimento pela língua, contra o palato; deglutição com projeção anterior de língua, diminuição da elevação de dorso de língua; elevação de palato mole e laringe adequada; diminuição de ejeção oral para líquido e função de clearance faríngeo completa para líquidos e sólidos. No exame pós-operatório, foi observada a posição habitual de língua em soalho da boca; mastigação com movimento compensatório de língua, com amassamento do alimento pela língua, contra o palato; elevação de palato mole e laringe adequada, ejeção oral satisfatória para líquido e função de clearance faríngeo completo para líquidos e sólidos. CONCLUSÃO: foi observado padrão adaptativo funcional em mastigação e deglutição mantido, mesmo após a cirurgia corretiva para a adequação da deformidade dentofacial, apesar da melhora da força de ejeção oral.BACKGROUND: the orofacial myofunctional disorders of individuals that have maxillomandibular disproportions can be related the orofacial muscular condition and the different functions accomplished by them. PROCEDURES: the patient was submitted to a radiographic video-fluoroscopic examination where in which we observed how many swallowing were needed to complete full cleaning of the valecular

  7. 下颌偏斜患者颌面结构特征及其与颈椎姿势相关性的研究%The relationship between dentofacial morphology and cervical vertebrae posture in patients with mandibular deviation

    Institute of Scientific and Technical Information of China (English)

    董研; 郭天文; 王美青; 王艳清

    2001-01-01

    Objective:To investigate the difference of cervical vertebrae alignment and dentofacial morphology between patients with mandibular deviation and persons with mormal occlusion .Methods:lateral cephalometric radiographs were taken in 20 patients with mandibular deviation and 41 young adults with normal occlusion.Morphometry was conducted using a software.Results: (1) The inclination of occlusion plane , mandibular plane and the curve of cervical vertebrae were all higher in mandibular deviation patients than those in normal occlusion persons. But the cervical vertebrae inclination was smaller in the patients. (2) The inclination of the dens and the cervical vertebrae plane showed positive correlation to Frankfort horizontal,palatal,occlusion and mandible plane. Each plane inclination was high in the cases with forward flexion dens in patient group;(3)The curve from the second cervical vertebrae to the fourth cervical vertebrae had a negative correlation to the dens and the cervical vertebrae plane inclination .The curve was small in the patients with forward flexion dens but large in those with backward flexion dens.Conclusion:Dentofacial morphology was correlated to cervical vertebrae alignment; furthermore,dentofacial morphology and cervical vertebrae posture in the patients with mandibular deviation are significantly different from those in the individuals with normal occlusion.%目的:探讨下颌偏斜者的颌面形态、颈椎姿势与正常牙 合者的差异;研究颌面形态与颈椎姿势的相关性。方法:对20例恒牙列下颌偏斜患者及41例正常咬合者拍摄自然头位时的头颅定位侧位片。结果:①下颌偏斜者咬合平面、下颌平面的陡度及颈椎弯曲度大于正常咬合者而颈椎倾斜度小于对照组,患者头呈前倾位;②下颌偏斜者的齿突倾斜度、颈椎平面倾斜度与眶耳平面、腭平面、咬合平面、下颌平面的倾斜度之间均呈正相关,齿突前倾时,各

  8. Effects of long-term treatment with testosterone on weight and waist size in 411 hypogonadal men with obesity classes I-III: observational data from two registry studies

    OpenAIRE

    Saad, F.; Yassin, A; Doros, G; Haider, A

    2015-01-01

    Background/Objectives: Long-term testosterone replacement therapy (TRT) up to 5 years has been shown to produce progressive and sustainable weight loss (WL) in hypogonadal men. This study investigated effects of long-term TRT up to 8 years in hypogonadal men with different obesity classes. Subjects/Methods: From two independent observational registries we identified a total of 411 obese, hypogonadal men receiving TRT in urological clinics. The effects of TRT on anthropometric as well as metab...

  9. 49 CFR 173.468 - Test for LSA-III material.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Test for LSA-III material. 173.468 Section 173.468... SHIPMENTS AND PACKAGINGS Class 7 (Radioactive) Materials § 173.468 Test for LSA-III material. (a) LSA-III Class 7 (radioactive) material must meet the test requirement of paragraph (b) of this section....

  10. My Class

    Institute of Scientific and Technical Information of China (English)

    赵传怡

    2006-01-01

    My name is Zhao Chuanyi.I am in Class Ten Grade seven.There are 61 students in our class.And 26 are girls and 35 are boys.One is from America.Boys like football and basketball.Girls like singing and dancing.We are all

  11. Word classes

    DEFF Research Database (Denmark)

    Rijkhoff, Jan

    2007-01-01

    a parts-of-speech system that includes the categories Verb, Noun, Adjective and Adverb, other languages may use only a subset of these four lexical categories. Furthermore, quite a few languages have a major word class whose members cannot be classified in terms of the categories Verb – Noun – Adjective...

  12. Class size versus class composition

    DEFF Research Database (Denmark)

    Jones, Sam

    Raising schooling quality in low-income countries is a pressing challenge. Substantial research has considered the impact of cutting class sizes on skills acquisition. Considerably less attention has been given to the extent to which peer effects, which refer to class composition, also may affect...... outcomes. This study uses new microdata from East Africa, incorporating test score data for over 250,000 children, to compare the likely efficacy of these two types of interventions. Endogeneity bias is addressed via fixed effects and instrumental variables techniques. Although these may not fully mitigate...

  13. Moran sets and Moran classes

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The purpose of this survey is to present Moran sets and Moran classes which generalize the classical selfsimilar sets from the following points: ( i ) The placements of the basic sets at each step of the constructions can be arbitrary; (ii) the contraction ratios may be different at each step; and (iii) the lower limit of the contraction ratios permits zero. In this discussion we will present geometrical properties and results of dimensions of these sets and classes,and discuss conformal Moran sets and random Moran sets as well.``

  14. Gold(III) Compounds as New Family of Anticancer Drugs

    OpenAIRE

    Luigi Messori; Giordana Marcon; Pierluigi Orioli

    2003-01-01

    Gold(III) complexes are emerging as a new class of metal complexes with outstanding cytotoxic properties and are presently being evaluated as potential antitumor agents. This renewed interest is the result of recent studies in which various gold(III) complexes have been shown to be stable under physiological conditions and to manifest relevant antiproliferative properties against selected human tumor cell lines. The pharmacological investigation of some representative gold(III) complexes has ...

  15. HLA class I expression in bladder carcinomas.

    Science.gov (United States)

    Cabrera, T; Pedrajas, G; Cozar, J M; Garrido, A; Vicente, J; Tallada, M; Garrido, F

    2003-10-01

    HLA class I molecules are frequently lost in a large variety of human carcinomas, possibly because of T-cell immune selection of major histocompatibility complex class I deficient tumor variants. We report that this phenomenon is also a frequent event in bladder carcinomas. Of a total of 72 bladder carcinomas, 72% of the tumors had at least one alteration in HLA class I expression. These altered HLA class I phenotypes were classified as total HLA class I loss (25%; phenotype I); HLA-A or/and HLA-B locus-specific loss (12%; phenotype III); and HLA class I allelic loss (35%; phenotype II or IV). Comparison of histopathological parameters with HLA class I expression showed a statistically significant relationship with the degree of differentiation and tumor recurrence.

  16. Class distinction

    Science.gov (United States)

    White, M. Catherine

    Typical 101 courses discourage many students from pursuing higher level science and math courses. Introductory classes in science and math serve largely as a filter, screening out all but the most promising students, and leaving the majority of college graduates—including most prospective teachers—with little understanding of how science works, according to a study conducted for the National Science Foundation. Because few teachers, particularly at the elementary level, experience any collegiate science teaching that stresses skills of inquiry and investigation, they simply never learn to use those methods in their teaching, the report states.

  17. Sub-classes and evolution stability of Wolfram's classesin the total-rule cellular automata

    Institute of Scientific and Technical Information of China (English)

    YAN Guangwu; TIAN Feng; DONG Yinfeng

    2004-01-01

    In this paper, we propose a concept of sub-classes and its evolution stability for the Wolfram's classes. Firstly, we obtain the sub-classes of the Wolfram's class IV, gene-piece of these sub-classes and their existing circumstance. Secondly, we introduce a new concept, the evolution stability, for the Wolfram's classes and sub-classes of Wolfram's class IV. Lastly, we find that Wolfram's classes I, II, and III have the evolution stability, but sub-classes of the Wolfram's class IV have not the evolution stability for the total rule cellular automata.

  18. Angle Class I malocclusion treated with lower incisor extraction

    Directory of Open Access Journals (Sweden)

    Vanessa Leal Tavares Barbosa

    2013-06-01

    Full Text Available In planning orthodontic cases that include extractions as an alternative to solve the problem of negative space discrepancy, the critical decision is to determine which teeth will be extracted. Several aspects must be considered, such as periodontal health, orthodontic mechanics, functional and esthetic alterations, and treatment stability. Despite controversies, extraction of teeth to solve dental crowding is a therapy that has been used for decades. Premolar extractions are the most common, but there are situations in which atypical extractions facilitate mechanics, preserve periodontal health and favor maintenance of the facial profile, which tends to unfavorably change due to facial changes with age. The extraction of a lower incisor, in selected cases, is an effective approach, and literature describes greater post-treatment stability when compared with premolar extractions. This article reports the clinical case of a patient with Angle Class I malocclusion and upper and lower anterior crowding, a balanced face and harmonious facial profile. The presence of gingival and bone recession limited large orthodontic movements. The molars and premolars were well occluded, and the discrepancy was mainly concentrated in the anterior region of the lower dental arch. The extraction of a lower incisor in the most ectopic position and with compromised periodontium, associated with interproximal stripping in the upper and lower arches, was the alternative of choice for this treatment, which restored function, providing improved periodontal health, maintained facial esthetics and allowed finishing with a stable and balanced occlusion. This case was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO, as part of the requirements for obtaining the BBO Diplomate title.

  19. Two new class III G6PD variants [G6PD Tunis (c.920A>C: p.307Gln>Pro) and G6PD Nefza (c.968T>C: p.323 Leu>Pro)] and overview of the spectrum of mutations in Tunisia.

    Science.gov (United States)

    Benmansour, Ikbel; Moradkhani, Kamran; Moumni, Imen; Wajcman, Henri; Hafsia, Raouf; Ghanem, Abderraouf; Abbès, Salem; Préhu, Claude

    2013-02-01

    We screened 423 patients referred to our laboratory after hemolysis triggered by fava beans ingestion, neonatal jaundice or drug hemolysis. Others were asymptomatic but belonged to a family with a history of G6PD deficiency. The determination of enzymatic activity using spectrophotometric method, revealed 293 deficient (143 males and 150 females). The molecular analysis was performed by a combination of PCR-RFLP and DNA sequencing to characterize the mutations causing G6PD deficiency. 14 different genotypes have been identified : G6PD A(-) (376A>G;202G>A) (46.07%) and G6PD Med (33.10%) were the most common variants followed by G6PD Santamaria (5.80%), G6PD Kaiping (3.75%), the association [c.1311T and IVS11 93c] (3.75%), G6PD Chatham (2.04%), G6PD Aures (1.70%), G6PD A(-) Betica (0.68%), the association [ 376G;c.1311T;IVS11 93c] (0.68%), G6PD Malaga, G6PD Canton and G6PD Abeno respectively (0.34%). Two novel missense mutations were identified (c.920A>C: p.307Gln>Pro and c.968T>C: p.323 Leu>Pro). We designated these two class III variants as G6PD Tunis and G6PD Nefza. A mechanism which could account for the defective activity is discussed. PMID:22963789

  20. Coronal type III radio bursts and their X-ray flare and interplanetary type III counterparts

    CERN Document Server

    Reid, Hamish A S

    2016-01-01

    Type III bursts and hard X-rays are both produced by flare energetic electron beams. The link between both emissions has been investigated in many previous studies, but no statistical studies have compared both coronal and interplanetary type III bursts with X-ray flares. Using coronal radio events above 100 MHz exclusively from type III bursts, we revisited long-standing questions: Do all coronal type III bursts have X-ray counterparts. What correlation, if any, occurs between radio and X-ray intensities. What X-ray and radio signatures above 100 MHz occur in connection with interplanetary type III bursts below 14 MHz. We analysed data from 2002 to 2011 starting with coronal type III bursts above 100 MHz. We used RHESSI X-ray data greater than 6 keV to make a list of 321 events that have associated type III bursts and X-ray flares, encompassing at least 28 percent of the initial sample of type III events. We examined the timings, intensities, associated GOES class, and any interplanetary radio signature. For...

  1. Compendium of Lecture Notes for Training Class III Meteorological Personnel.

    Science.gov (United States)

    Retallack, B. J.

    This compendium of lecture notes provides a course of study for persons who may be involved in a variety of specialized meteorological tasks. The course is considered to be advanced and assumes students have had introductory experiences in meteorology and earth science (covered in a similar compendium). The material is presented in seven units…

  2. PENGGUNAAN INCLINED BITE PLANE SEBAGAI ALAT BANTU UNTUK KOREKSI GIGITAN SILANG ANTERIOR PADA KASUS MALOKLUSI KLAS III SKELETAL

    OpenAIRE

    Amutavia P. Artsianti P.; Erwin Siregar

    2015-01-01

    Anterior crossbite occurs in children and adult. This anterior crossbite could be a dental (pseudo class III) or a skeletal class III malocclusions. A 15 year old young female came to orthodontic clinic RSGM FKGUI with maxillary dental crowding which canines were more protruded. The dental of mandible were more protruded than maxillary dental. The clinical examination, anamnesis, functional analyses and cephalometric evaluation and model study showed that it was a skeletal class III malocclus...

  3. Social class and parental investment in children

    NARCIS (Netherlands)

    Gauthier, A.H.; Scott, Robert A.; Kosslyn, Stephen M.

    2015-01-01

    This essay critically reviews the literature on social class differences in parental investment in children including differences in (i) parenting practices or behavior; (ii) parenting styles, logics, and strategies; and (iii) parenting values and ideologies. The essay reveals how structural and cul

  4. Class IIa Bacteriocins: Current Knowledge and Perspectives

    Science.gov (United States)

    Belguesmia, Yanath; Naghmouchi, Karim; Chihib, Nour-Eddine; Drider, Djamel

    Lactic acid bacteria (LAB) are known to produce antibacterial peptides and small proteins called bacteriocins, which enable them to compete against other bacteria in the environment. Bacteriocins fall structurally and chemically into three different classes, I, II, and III. Bacteriocins are ribosomally synthesized peptides with antagonism against closely related bacteria. This late observation has evolved because bacteriocins active against Gram-negative bacteria have recently been reported. Members of class IIa bacteriocins, referred to as pediocin-like bacteriocins, are among the most studied bacteriocins. This chapter is aimed at providing an updated review on the biology of class IIa bacteriocins.

  5. Tratamento conservador de uma má oclusão Classe I de Angle, com atresia maxilar e apinhamento anterior The conservative treatment of Class I malocclusion with maxillary transverse deficiency and anterior teeth crowding

    Directory of Open Access Journals (Sweden)

    Lincoln I. Nojima

    2011-10-01

    Full Text Available Este artigo relata o tratamento de uma paciente do sexo feminino, com 15 anos de idade, má oclusão Classe I de Angle, severo apinhamento anterossuperior, desvio da linha média superior para o lado esquerdo e atresia maxilar, associada à mordida cruzada posterior. Os procedimentos executados envolveram a expansão maxilar com disjuntor palatino do tipo Haas modificado e montagem de aparelho fixo com sistema Edgewise standard. Foram realizados desgastes proximais nos incisivos e caninos inferiores para o alinhamento anterior, bem como redução da discrepância de Bolton com excesso inferior. Esse caso foi apresentado à diretoria do Board Brasileiro de Ortodontia e Ortopedia Facial (BBO, representando a categoria livre escolha, como parte dos requisitos para a obtenção do título de Diplomado pelo BBO.This article reports the treatment of a 15-years-old female patient, with Class I malocclusion, severe upper anterior crowding, midline deviation to the left side and maxillary transverse deficiency associated with posterior crossbite. The procedures involved rapid maxillary expansion with modified Haas appliance and the use of Edgewise standard system. Proximal wear were performed to the alignment of mandibular incisors, as well as to reduce the Bolton discrepancy. This case was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO, representative of category free, as partial fulfillment of the requirements for obtaining the title of BBO Diplomate.

  6. Treatment of Class II high angle malocclusions with the Herbst appliance: a cephalometric investigation.

    Science.gov (United States)

    Schiavoni, R; Grenga, V; Macri, V

    1992-11-01

    The purpose of this study was to examine the results of treatment of Class II malocclusions by using two different designs of the Herbst appliance. Cephalometric records from lateral headplates of 19 consecutively treated Class II cases were evaluated. The headplates were taken before and after the treatment stage in which the Herbst appliance was used. The patients were divided into two groups: the first group, normohypodivergent, was treated with the Herbst appliance attached to bands; the second group, hyperdivergent, was treated with the Herbst appliance attached to acrylic splints in which a high-pull headgear was also used. The results were compared between these groups and with a control group age-matched from Bolton standards to match the changes in the Herbst samples against what might be expected in case of normal growth during similar periods of time. The results of the investigation revealed the following: (1) 9 months of treatment resulted in Class I dental arch relationships in all 19 cases; (2) the Herbst appliance attached to bands did not significantly modify the vertical growth pattern of the normohypodivergent patients; and (3) in hyperdivergent patients, the use of a Herbst appliance attached to acrylic splints in conjunction with the use of a high-pull headgear allowed a better control of the vertical dimension, as assessed by the cephalometric parameters (FA, FMA, Go-Gn-SN). The clinician should be aware of the different dentofacial changes induced in the vertical plane by different designs of the Herbst appliance to better program treatment strategy.

  7. Class Vectors: Embedding representation of Document Classes

    OpenAIRE

    Sachan, Devendra Singh; Kumar, Shailesh

    2015-01-01

    Distributed representations of words and paragraphs as semantic embeddings in high dimensional data are used across a number of Natural Language Understanding tasks such as retrieval, translation, and classification. In this work, we propose "Class Vectors" - a framework for learning a vector per class in the same embedding space as the word and paragraph embeddings. Similarity between these class vectors and word vectors are used as features to classify a document to a class. In experiment o...

  8. The type III manufactory

    CERN Document Server

    Palcoux, Sébastien

    2011-01-01

    Using unusual objects in the theory of von Neumann algebra, as the chinese game Go or the Conway game of life (generalized on finitely presented groups), we are able to build, by hands, many type III factors.

  9. Workshop 96. Part III

    International Nuclear Information System (INIS)

    Part III of the proceedings contain 155 contributions in various fields of science and technology including nuclear engineering, environmental science, and biomedical engineering. Out of these, 10 were selected to be inputted in INIS. (P.A.)

  10. Does Class Size Matter?

    Science.gov (United States)

    Ehrenberg, Ronald G.; Brewer, Dominic J.; Gamoran, Adam; Willms, J. Douglas

    2001-01-01

    Reports on the significance of class size to student learning. Includes an overview of class size in various countries, the importance of teacher adaptability, and the Asian paradox of large classes allied to high test scores. (MM)

  11. RxClass

    Data.gov (United States)

    U.S. Department of Health & Human Services — The RxClass Browser is a web application for exploring and navigating through the class hierarchies to find the RxNorm drug members associated with each class....

  12. A Virtual Class Calculus

    DEFF Research Database (Denmark)

    Ernst, Erik; Ostermann, Klaus; Cook, William Randall

    2006-01-01

    , not as static components of a class. When used as types, virtual classes depend upon object identity - each object instance introduces a new family of virtual class types. Virtual classes support large scale program composition techniques, including higher-order hierarchies and family polymorphism. The original......Virtual classes are class-valued attributes of objects. Like virtual methods, virtual classes are defined in an object's class and may be redefined within subclasses. They resemble inner classes, which are also defined within a class, but virtual classes are accessed through object instances...... definition of virtual classes in BETA left open the question of static type safety, since some type errors were not caught until runtime. Later the languages Caesar and gbeta have used a more strict static analysis in order to ensure static type safety. However, the existence of a sound, statically typed...

  13. Protein-water dynamics in antifreeze protein III activity

    Science.gov (United States)

    Xu, Yao; Bäumer, Alexander; Meister, Konrad; Bischak, Connor G.; DeVries, Arthur L.; Leitner, David M.; Havenith, Martina

    2016-03-01

    We combine Terahertz absorption spectroscopy (THz) and molecular dynamics (MD) simulations to investigate the underlying molecular mechanism for the antifreeze activity of one class of antifreeze protein, antifreeze protein type III (AFP-III) with a focus on the collective water hydrogen bond dynamics near the protein. After summarizing our previous work on AFPs, we present a new investigation of the effects of cosolutes on protein antifreeze activity by adding sodium citrate to the protein solution of AFP-III. Our results reveal that for AFP-III, unlike some other AFPs, the addition of the osmolyte sodium citrate does not affect the hydrogen bond dynamics at the protein surface significantly, as indicated by concentration dependent THz measurements. The present data, in combination with our previous THz measurements and molecular simulations, confirm that while long-range solvent perturbation is a necessary condition for the antifreeze activity of AFP-III, the local binding affinity determines the size of the hysteresis.

  14. Má oclusão Classe I de Angle, com mordida aberta anterior, tratada com extração de dentes permanentes Angle Class I malocclusion, with anterior open bite, treated with extraction of permanent teeth

    Directory of Open Access Journals (Sweden)

    Mírian Aiko Nakane Matsumoto

    2011-02-01

    Full Text Available A mordida aberta é uma anomalia com características distintas que, além da complexidade dos múltiplos fatores etiológicos, traz consequências estéticas e funcionais. Muitas alternativas têm sido utilizadas em seu tratamento, entre elas a grade palatina, forças ortopédicas, ajuste oclusal, camuflagem com ou sem exodontias, mini-implantes ou miniplacas e cirurgia ortognática. O diagnóstico preciso e a determinação da etiologia permitem estabelecer os objetivos e o plano de tratamento ideal para essa má oclusão. O presente relato descreve o tratamento de uma má oclusão Classe I de Angle, com padrão esquelético de Classe II e mordida aberta anterior, realizado em duas fases e que foi apresentado à diretoria do Board Brasileiro de Ortodontia e Ortopedia Facial (BBO, representando a categoria 2, como parte dos requisitos para a obtenção do título de Diplomado pelo BBO.Open bite is an anomaly with distinct characteristics which, in addition to involving complex, multiple etiologic factors, entails aesthetic and functional consequences. Many alternative approaches have been employed to treat open bite, including palatal crib, orthopedic forces, occlusal adjustment, camouflage with or without extractions, mini-implants or mini-plates, and orthognathic surgery. By determining accurate diagnosis and etiology professionals can set the goals and ideal treatment plan for this malocclusion. This report, describing the two stages treatment of a Angle Class I malocclusion with Class II skeletal pattern and anterior open bite, was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO, representative of category 2, as partial fulfillment of the requirements for obtaining the title of BBO Diplomate.

  15. Lutetium(III cyclotetraphosphate

    Directory of Open Access Journals (Sweden)

    Aïcha Mbarek

    2010-06-01

    Full Text Available Single crystals of the title compound, tetralutetium(III tris(cyclotetraphosphate, Lu4(P4O123, were obtained by solid-state reaction. The cubic structure is isotypic with its AlIII and ScIII analogues and is built up from four-membered (P4O124− phosphate ring anions (overline{4} symmetry, isolated from each other and further linked through isolated LuO6 octahedra (.3. symmetry via corner sharing. Each LuO6 octahedron is linked to six (P4O124− rings, while each (P4O124− ring is linked to eight LuO6 octahedra.

  16. Fusion Power Demonstration III

    International Nuclear Information System (INIS)

    This is the third in the series of reports covering the Fusion Power Demonstration (FPD) design study. This volume considers the FPD-III configuration that incorporates an octopole end plug. As compared with the quadrupole end-plugged designs of FPD-I and FPD-II, this octopole configuration reduces the number of end cell magnets and shortens the minimum ignition length of the central cell. The end-cell plasma length is also reduced, which in turn reduces the size and cost of the end cell magnets and shielding. As a contiuation in the series of documents covering the FPD, this report does not stand alone as a design description of FPD-III. Design details of FPD-III subsystems that do not differ significantly from those of the FPD-II configuration are not duplicated in this report

  17. III-V microelectronics

    CERN Document Server

    Nougier, JP

    1991-01-01

    As is well known, Silicon widely dominates the market of semiconductor devices and circuits, and in particular is well suited for Ultra Large Scale Integration processes. However, a number of III-V compound semiconductor devices and circuits have recently been built, and the contributions in this volume are devoted to those types of materials, which offer a number of interesting properties. Taking into account the great variety of problems encountered and of their mutual correlations when fabricating a circuit or even a device, most of the aspects of III-V microelectronics, from fundamental p

  18. Polymerase (Pol) III TATA Box-Binding Protein (TBP)-Associated Factor Brf Binds to a Surface on TBP Also Required for Activated Pol II Transcription

    OpenAIRE

    Shen, Yuhong; Kassavetis, George A.; Bryant, Gene O.; Berk, Arnold J.

    1998-01-01

    The TATA box-binding protein (TBP) plays an essential role in transcription by all three eukaryotic nuclear RNA polymerases, polymerases (Pol) I, II, and III. In each case, TBP interacts with class-specific TBP-associated factors (TAFs) to form class-specific transcription initiation factors. For yeast Pol III transcription, TBP associates with Brf (from TFIIB-related factor) and B", two Pol III TAFs, to form Pol III transcription factor TFIIIB. Here, we identify TBP surface residues that are...

  19. Summary of Session III

    OpenAIRE

    Furman, M.A.

    2002-01-01

    This is a summary of the talks presented in Session III "Simulations of Electron-Cloud Build Up" of the Mini-Workshop on Electron-Cloud Simulations for Proton and Positron Beams ECLOUD-02, held at CERN, 15-18 April 2002.

  20. Metallothionein (MT)-III

    DEFF Research Database (Denmark)

    Carrasco, J; Giralt, M; Molinero, A;

    1999-01-01

    Metallothionein-III is a low molecular weight, heavy-metal binding protein expressed mainly in the central nervous system. First identified as a growth inhibitory factor (GIF) of rat cortical neurons in vitro, it has subsequently been shown to be a member of the metallothionein (MT) gene family...

  1. Calculus III essentials

    CERN Document Server

    REA, Editors of

    2012-01-01

    REA's Essentials provide quick and easy access to critical information in a variety of different fields, ranging from the most basic to the most advanced. As its name implies, these concise, comprehensive study guides summarize the essentials of the field covered. Essentials are helpful when preparing for exams, doing homework and will remain a lasting reference source for students, teachers, and professionals. Calculus III includes vector analysis, real valued functions, partial differentiation, multiple integrations, vector fields, and infinite series.

  2. Ultradiscrete limit of Bessel function type solutions of the Painlev\\'{e} III equation

    OpenAIRE

    Isojima, Shin

    2014-01-01

    An ultradiscrete analog of the Bessel function is constructed by taking the ultradiscrete limit for a $q$-difference analog of the Bessel function. Then, a direct relationship between a class of special solutions for the ultradiscrete Painlev\\'{e} III equation and those of the discrete Painlev\\'{e} III equation which have a determinantal structure is established.

  3. Variable-Voltage Class-E Power Amplifiers

    NARCIS (Netherlands)

    Acar, Mustafa; Annema, Anne Johan; Nauta, Bram

    2007-01-01

    The Class-E power amplifier is widely used due to its high efficiency, resulting from switching at zero voltage and zero slope of the switch voltage. In this paper, we extend general analytical solutions for the Class-E power amplifier to the ideal single-ended Variable-Voltage Class-E (Class-EVV) p

  4. Semisimple Classes of Semirings

    Institute of Scientific and Technical Information of China (English)

    U. Hebisch; H.J. Weinert

    2002-01-01

    A famous result of Sands states that a class S of associative rings is semisimple if and only if S is regular, coinductive, and extensionally closed. Here,we investigate semisimple classes in a Kurosh-Amitsur radical theory for semirings. We show that such a class S is regular, K-coinductive, and K-extensionally closed. But a characterization of semisimple classes of semirings needs a fourth condition, namely that S is inverse semi-isomorphically closed. We also obtain other characterizations and results for semisimple classes and for subdirect products of semirings.

  5. Loosely coupled class families

    DEFF Research Database (Denmark)

    Ernst, Erik

    2001-01-01

    are expressed using virtual classes seem to be very tightly coupled internally. While clients have achieved the freedom to dynamically use one or the other family, it seems that any given family contains a xed set of classes and we will need to create an entire family of its own just in order to replace one...... of the members with another class. This paper shows how to express class families in such a manner that the classes in these families can be used in many dierent combinations, still enabling family polymorphism and ensuring type safety....

  6. Class, Culture and Politics

    DEFF Research Database (Denmark)

    Harrits, Gitte Sommer

    2013-01-01

    Even though contemporary discussions of class have moved forward towards recognizing a multidimensional concept of class, empirical analyses tend to focus on cultural practices in a rather narrow sense, that is, as practices of cultural consumption or practices of education. As a result......, discussions within political sociology have not yet utilized the merits of a multidimensional conception of class. In light of this, the article suggests a comprehensive Bourdieusian framework for class analysis, integrating culture as both a structural phenomenon co-constitutive of class and as symbolic...

  7. Semantic Analysis of Virtual Classes and Nested Classes

    DEFF Research Database (Denmark)

    Madsen, Ole Lehrmann

    1999-01-01

    Virtual classes and nested classes are distinguishing features of BETA. Nested classes originated from Simula, but until recently they have not been part of main stream object- oriented languages. C++ has a restricted form of nested classes and they were included in Java 1.1. Virtual classes is the...... classes and parameterized classes have been made. Although virtual classes and nested classes have been used in BETA for more than a decade, their implementation has not been published. The purpose of this paper is to contribute to the understanding of virtual classes and nested classes by presenting the...

  8. Class network routing

    Science.gov (United States)

    Bhanot, Gyan; Blumrich, Matthias A.; Chen, Dong; Coteus, Paul W.; Gara, Alan G.; Giampapa, Mark E.; Heidelberger, Philip; Steinmacher-Burow, Burkhard D.; Takken, Todd E.; Vranas, Pavlos M.

    2009-09-08

    Class network routing is implemented in a network such as a computer network comprising a plurality of parallel compute processors at nodes thereof. Class network routing allows a compute processor to broadcast a message to a range (one or more) of other compute processors in the computer network, such as processors in a column or a row. Normally this type of operation requires a separate message to be sent to each processor. With class network routing pursuant to the invention, a single message is sufficient, which generally reduces the total number of messages in the network as well as the latency to do a broadcast. Class network routing is also applied to dense matrix inversion algorithms on distributed memory parallel supercomputers with hardware class function (multicast) capability. This is achieved by exploiting the fact that the communication patterns of dense matrix inversion can be served by hardware class functions, which results in faster execution times.

  9. ABS 497 Complete Class

    OpenAIRE

    admin

    2015-01-01

    ABS 497 Complete Class   To purchase this material click below link   http://www.assignmentcloud.com/ABS-497/ABS-497-Complete-Class-Guide   For more classes visit   www.assignmentcloud.com   ABS 497 Week 1 Assignment Community Change ABS 497 Week 1 DQ 1 Fabian's Story ABS 497 Week 1 DQ 2 Doug's Story ABS 497 Week 2 DQ 1 Parenting Styles ABS 497 Week 2 DQ 2 Ethnicity and Learning Theory ABS 497 Week 3 ...

  10. Fostering a Middle Class

    Institute of Scientific and Technical Information of China (English)

    YAO BIN

    2011-01-01

    Though there is no official definition of "middle class" in China,the tag has become one few Chinese people believe they deserve anyway.In early August,the Chinese Academy of Social Sciences released a report on China's urban development,saying China had a middle-class population of 230 million in 2009,or 37 percent of its urban residents.It also forecast half of city dwellers in China would be part of the middle class by 2023.

  11. Genetics Home Reference: mucopolysaccharidosis type III

    Science.gov (United States)

    ... Understand Genetics Home Health Conditions mucopolysaccharidosis type III mucopolysaccharidosis type III Enable Javascript to view the expand/ ... boxes. Print All Open All Close All Description Mucopolysaccharidosis type III (MPS III), also known as Sanfilippo ...

  12. A Case Study of Middle Class African American Males Taking Advanced Mathematics Classes in High School

    OpenAIRE

    Jones, Zella Higginbotham

    2011-01-01

    African American males in all socioeconomic levels are underperforming in school. Many researchers have conducted studies hoping to find reasons for the underperformance. This study focused on three middle class African American males in a suburban school district. These African American male students took upper level math courses that included Algebra III, Math Analysis, AP Calculus, and AP Statistics. This study modeled the study by E. Wayne Harris. He believed students were influenced...

  13. Teaching Large Evening Classes

    Science.gov (United States)

    Wambuguh, Oscar

    2008-01-01

    High enrollments, conflicting student work schedules, and the sheer convenience of once-a-week classes are pushing many colleges to schedule evening courses. Held from 6 to 9 pm or 7 to 10 pm, these classes are typically packed, sometimes with more than 150 students in a large lecture theater. How can faculty effectively teach, control, or even…

  14. Universality classes of inflation

    NARCIS (Netherlands)

    Roest, Diederik

    2014-01-01

    We investigate all single-field, slow-roll inflationary models whose slow-roll parameters scale as 1/N in the limit of a large number of e-folds N. We proof that all such models belong to two universality classes, characterised by a single parameter. One class contains small field models like hillto

  15. DEFINING THE MIDDLE CLASS

    Institute of Scientific and Technical Information of China (English)

    WANG HAIRONG

    2011-01-01

    China's cities housed more than 230 million middle-class residents in 2009ot 37 percent of the urban population,according to the 2011 Blue Book of Cities in China released on August 3.In China's main urban centers,Beijing and Shanghai,the middle class accounted for 46 percent and 38 percent,respectively,of the local population.

  16. Teaching Social Class

    Science.gov (United States)

    Tablante, Courtney B.; Fiske, Susan T.

    2015-01-01

    Discussing socioeconomic status in college classes can be challenging. Both teachers and students feel uncomfortable, yet social class matters more than ever. This is especially true, given increased income inequality in the United States and indications that higher education does not reduce this inequality as much as many people hope. Resources…

  17. The Last Class

    Science.gov (United States)

    Uhl, Christopher

    2005-01-01

    The last class of the semester is like a goodbye. It can be cold and perfunctory or warm and heartfelt. For many years, I erred on the side of "cold and perfunctory." No more. Now my last classes are a time of celebration and ritual as I invite students to focus on qualities such as acceptance and gratitude.

  18. Class in disguise

    DEFF Research Database (Denmark)

    Faber, Stine Thidemann; Prieur, Annick

    This paper asks how class can have importance in one of the worlds’ most equal societies: Denmark. The answer is that class here appears in disguised forms. The field under study is a city, Aalborg, in the midst of transition from a stronghold of industrialism to a post industrial economy...

  19. DEFINING THE MIDDLE CLASS

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Classifying the middle class remains controversial despite its alleged growth China’s cities housed more than 230 million middle-class residents in 2009 or 37 percent of the urban population,according to the 2011 Blue Book of Cities in China released on August 3.

  20. Oxymatrinium tetrachloridoferrate(III

    Directory of Open Access Journals (Sweden)

    Xiong He

    2012-02-01

    Full Text Available The asymmetric unit of the title compound, (C15H25N2O2[FeCl4], contains a tetrachloridoferrate(III anion and a oxymatrinium cation [oxymatrine is (4R,7aS,13aR,13bR,13cS-dodecahydro-1H,5H,10H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one 4-oxide]. The conformation of oxymatrine is similar to that of matrine with one ring having a half-chair conformation, while the others have chair conformations. Chiral chains of cations along the c axis are formed by O—H...O hydrogen bonds.

  1. Ammonium diphosphitoindate(III

    Directory of Open Access Journals (Sweden)

    Farida Hamchaoui

    2013-04-01

    Full Text Available The crystal structure of the title compound, NH4[In(HPO32], is built up from InIII cations (site symmetry 3m. adopting an octahedral environment and two different phosphite anions (each with site symmetry 3m. exhibiting a triangular–pyramidal geometry. Each InO6 octahedron shares its six apices with hydrogen phosphite groups. Reciprocally, each HPO3 group shares all its O atoms with three different metal cations, leading to [In(HPO32]− layers which propagate in the ab plane. The ammonium cation likewise has site symmetry 3m.. In the structure, the cations are located between the [In(HPO32]− layers of the host framework. The sheets are held together by hydrogen bonds formed between the NH4+ cations and the O atoms of the framework.

  2. Semiconducting III-V compounds

    CERN Document Server

    Hilsum, C; Henisch, Heinz R

    1961-01-01

    Semiconducting III-V Compounds deals with the properties of III-V compounds as a family of semiconducting crystals and relates these compounds to the monatomic semiconductors silicon and germanium. Emphasis is placed on physical processes that are peculiar to III-V compounds, particularly those that combine boron, aluminum, gallium, and indium with phosphorus, arsenic, and antimony (for example, indium antimonide, indium arsenide, gallium antimonide, and gallium arsenide).Comprised of eight chapters, this book begins with an assessment of the crystal structure and binding of III-V compounds, f

  3. Comparisons of ASME-code fatigue-evaluation methods for nuclear Class 1 piping with Class 2 or 3 piping

    International Nuclear Information System (INIS)

    The fatigue evaluation procedure used in the ASME Boiler and Pressure Vessel Code, Sect. III, Nuclear Power Plant Components, for Class 1 piping is different from the procedure used for Class 2 or 3 piping. The basis for each procedure is described, and correlations between the two procedures are presented. Conditions under which either procedure or both may be unconservative are noted. Potential changes in the Class 2 or 3 piping procedure to explicitly cover all loadings are discussed. However, the report is intended to be informative, and while the contents of the report may guide future Code changes, specific recommendations are not given herein

  4. Social Class Dialogues and the Fostering of Class Consciousness

    Science.gov (United States)

    Madden, Meredith

    2015-01-01

    How do critical pedagogies promote undergraduate students' awareness of social class, social class identity, and social class inequalities in education? How do undergraduate students experience class consciousness-raising in the intergroup dialogue classroom? This qualitative study explores undergraduate students' class consciousness-raising in an…

  5. ROSA-III system description

    International Nuclear Information System (INIS)

    The ROSA-III system and its instrumentations are described. The informations are necessary to understand and analyze the experimental data obtained from loss-of-coolant experiments (LOCEs) conducted in the ROSA (Rig of Safety Assessment)-III facility. (author)

  6. Teaching groundwater dynamics: connecting classroom to practical and field classes

    Science.gov (United States)

    Hakoun, V.; Mazzilli, N.; Pistre, S.; Jourde, H.

    2013-01-01

    Preparing future hydrogeologists to provide inputs in societal discussions in a changing world is a challenging task that induces a need for efficient teaching frameworks. The educational literature suggests that hydrogeology courses should consistently integrate classroom instruction with practical and field classes. However, most teaching examples still separate these three class components. This paper presents an introductory course to groundwater dynamics taught at the Université des Sciences de Montpellier, France. The adopted pedagogical scheme and the proposed activities are described in details. The key points of the proposed course are: (i) an educational scheme that iteratively links groundwater dynamics topics to the three class components, (ii) a course that is structured around a main thread (well testing) called in each class component, (iii) a pedagogical approach that promotes active learning strategies, in particular using original practical classes and field experiments. The experience indicates that the proposed scheme improves the learning process, as compared to a classical, teacher-centered approach.

  7. PSYCH 515 Complete Class

    OpenAIRE

    admin

    2015-01-01

      PSYCH 515 Advanced Abnormal Psychology To purchase this material click on below link http://www.assignmentcloud.com/PSYCH-515/PSYCH-515-Complete-Class-Guide For more details www.assignmentcloud.com

  8. Raradox of class description

    Institute of Scientific and Technical Information of China (English)

    吕光

    2004-01-01

    We have a more active class atmophere, but more passive self-study situations. We are too talktive when we should bury ourselves in books, but too less efficient when we spend too much time. We complain teachers

  9. IELP Class Observation

    Institute of Scientific and Technical Information of China (English)

    陈了了

    2010-01-01

    @@ As an exchange student majoring in English, I am curious about how English is taught to international students here in America. Therefore, I observed an IELP (Intensive English Learning Program) class in Central Connecticut State University where I study.

  10. Teaching Heterogeneous Classes.

    Science.gov (United States)

    Millrood, Radislav

    2002-01-01

    Discusses an approach to teaching heterogeneous English-as-a-Second/Foreign-Language classes. Draws on classroom research data to describe the features of a success-building lesson context. (Author/VWL)

  11. A class in astrobiology

    Science.gov (United States)

    Airieau, S. A.

    1999-09-01

    The goal of this class is to provide basic astrobiology knowledge to upper division science students. The scope is broad and in-depth coverage is not possible in this introductory course. Instead, science students from various branches of academia can acquire a broad basis and understanding of the other fields: astronomy, biology, geology, biochemistry, planetary and space sciences. The class is highly modular and allows instructors to concentrate on or eliminate topics according to their priorities and preferences.

  12. Nordic Walking Classes

    CERN Multimedia

    Fitness Club

    2015-01-01

    Four classes of one hour each are held on Tuesdays. RDV barracks parking at Entrance A, 10 minutes before class time. Spring Course 2015: 05.05/12.05/19.05/26.05 Prices 40 CHF per session + 10 CHF club membership 5 CHF/hour pole rental Check out our schedule and enroll at: https://espace.cern.ch/club-fitness/Lists/Nordic%20Walking/NewForm.aspx? Hope to see you among us! fitness.club@cern.ch

  13. Generalized Fourier transforms classes

    DEFF Research Database (Denmark)

    Berntsen, Svend; Møller, Steen

    2002-01-01

    The Fourier class of integral transforms with kernels $B(\\omega r)$ has by definition inverse transforms with kernel $B(-\\omega r)$. The space of such transforms is explicitly constructed. A slightly more general class of generalized Fourier transforms are introduced. From the general theory foll...... follows that integral transform with kernels which are products of a Bessel and a Hankel function or which is of a certain general hypergeometric type have inverse transforms of the same structure....

  14. Embodying class and gender

    OpenAIRE

    Geers, Alexie

    2015-01-01

    In March 1937, when the first issue of Marie-Claire was published, the images of the female body it presented to its female readers from working-class backgrounds contrasted sharply with those featured in previous magazines. The female bodies are dressed and groomed to seduce and replace the hieratic bodies that presented fashions synonymous with membership in the upper classes. The present essay examines this shift and shows that the visual repertoire employed is borrowed from that of the fe...

  15. PREFACE: Quantum Optics III

    Science.gov (United States)

    Orszag, M.; Retamal, J. C.; Saavedra, C.; Wallentowitz, S.

    2007-06-01

    All the 50 years of conscious pondering did not bring me nearer to an answer to the question `what is light quanta?'. Nowadays, every rascal believes, he knows it, however, he is mistaken. (A Einstein, 1951 in a letter to M Besso) Quantum optics has played a key role in physics in the last several decades. On the other hand, in these early decades of the information age, the flow of information is becoming more and more central to our daily life. Thus, the related fields of quantum information theory as well as Bose-Einstein condensation have acquired tremendous importance in the last couple of decades. In Quantum Optics III, a fusion of these fields appears in a natural way. Quantum Optics III was held in Pucón, Chile, in 27-30 of November, 2006. This beautiful location in the south of Chile is near the lake Villarrica and below the snow covered volcano of the same name. This fantastic environment contributed to a relaxed atmosphere, suitable for informal discussion and for the students to have a chance to meet the key figures in the field. The previous Quantum Optics conferences took place in Santiago, Chile (Quantum Optics I, 2000) and Cozumel, Mexico (Quantum Optics II, 2004). About 115 participants from 19 countries attended and participated in the meeting to discuss a wide variety of topics such as quantum-information processing, experiments related to non-linear optics and squeezing, various aspects of entanglement including its sudden death, correlated twin-photon experiments, light storage, decoherence-free subspaces, Bose-Einstein condensation, discrete Wigner functions and many more. There was a strong Latin-American participation from Argentina, Brazil, Chile, Colombia, Peru, Uruguay, Venezuela and Mexico, as well as from Europe, USA, China, and Australia. New experimental and theoretical results were presented at the conference. In Latin-America a quiet revolution has taken place in the last twenty years. Several groups working in quantum optics and

  16. Translation in ESL Classes

    Directory of Open Access Journals (Sweden)

    Nagy Imola Katalin

    2015-12-01

    Full Text Available The problem of translation in foreign language classes cannot be dealt with unless we attempt to make an overview of what translation meant for language teaching in different periods of language pedagogy. From the translation-oriented grammar-translation method through the complete ban on translation and mother tongue during the times of the audio-lingual approaches, we have come today to reconsider the role and status of translation in ESL classes. This article attempts to advocate for translation as a useful ESL class activity, which can completely fulfil the requirements of communicativeness. We also attempt to identify some activities and games, which rely on translation in some books published in the 1990s and the 2000s.

  17. Talking Class in Tehroon

    DEFF Research Database (Denmark)

    Elling, Rasmus Christian; Rezakhani, Khodadad

    2016-01-01

    Persian, like any other language, is laced with references to class, both blatant and subtle. With idioms and metaphors, Iranians can identify and situate others, and thus themselves, within hierarchies of social status and privilege, both real and imagined. Some class-related terms can be traced...... back to medieval times, whereas others are of modern vintage, the linguistic legacy of television shows, pop songs, social media memes or street vernacular. Every day, it seems, an infectious set of phrases appears that make yesterday’s seem embarrassingly antiquated....

  18. MIDDLE CLASS MOVEMENTS

    OpenAIRE

    Dr. K. Sravana Kumar

    2016-01-01

                The middle class is placed between labour and capital. It neither directly awns the means of production that pumps out the surplus generated by wage labour power, nor does it, by its own labour, produce the surplus which has use and exchange value. Broadly speaking, this class consists of the petty bourgeoisie and the white-collar workers. The former are either self-employed or involved in the distribution of commodities and t...

  19. Class Actions in Denmark

    DEFF Research Database (Denmark)

    Werlauff, Erik

    2009-01-01

    The article deals with the relatively new Danish Act on Class Action (Danish: gruppesøgsmål) which was suggested by The Permanent Council on Civil procedure (Retsplejerådet) of which the article's author is a member. The operability of the new provisions is illustrated through some wellknown Dani...... cases: Hafnia case (investment prospectus), and Danish Eternit (roof elements) where the existence of Danish provisions on class actions might have made a difference, and the article also deals with the delicate questions of opt-in and opt-out....

  20. Residues of Chern classes

    OpenAIRE

    Suwa, Tatsuo; 諏訪, 立雄

    2003-01-01

    If we have a finite number of sections of a complex vector bundle E over a manifold M, certain Chern classes of E are localized at the singular set S, i.e., the set of points where the sections fail to be linearly independent. When S is compact, the localizations define the residues at each connected component of S by the Alexander duality. If M itself is compact, the sum of the residues is equal to the Poincaré dual of the corresponding Chern class. This type of theory is also developed for ...

  1. Residues of Chern classes

    OpenAIRE

    Suwa, Tatsuo

    2003-01-01

    If we have a finite number of sections of a complex vector bundle $E$ over a manifold $M$ , certain Chern classes of $E$ are localized at the singular set $S$ , i.e., the set of points where the sections fail to be linearly independent. When $S$ is compact, the localizations define the residues at each connected component of $S$ by the Alexander duality. If $M$ itself is compact, the sum of the residues is equal to the Poincaré dual of the corresponding Chern class. This type of theory is als...

  2. Celestine III and the North

    DEFF Research Database (Denmark)

    Nielsen, Torben Kjersgaard

    2008-01-01

    Artiklen gennemgår pave Cølestin IIIs forhold til de nordiske kongeriger i perioden 1191-1198. Artiklen viser, at paven, som i forskningen traditionelt år har stået i skyggen af sin berømte, energiske og især: yngre efterfølger, Innocens III, har været på forkant med udviklingen i de nordiske rig...

  3. Reference class forecasting

    DEFF Research Database (Denmark)

    Flyvbjerg, Bent

    Underbudgettering og budgetoverskridelser forekommer i et flertal af større bygge- og anlægsprojekter. Problemet skyldes optimisme og/eller strategisk misinformation i budgetteringsprocessen. Reference class forecasting (RCF) er en prognosemetode, som er udviklet for at reducere eller eliminere...

  4. Fostering a Middle Class

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Though there is no official definition of "middle class" in China, the tag has become one few Chinese people believe they deserve anyway.In early August, the Chinese Academy of Social Sciences released a report on China’s urban development,

  5. Openers for Biology Classes.

    Science.gov (United States)

    Gridley, C. Robert R.

    This teaching guide contains 200 activities that are suitable for openers and demonstrations in biology classes. Details are provided regarding the use of these activities. Some of the broad topics under which the activities are organized include algae, amphibians, bacteria, biologists, crustaceans, dinosaurs, ecology, evolution, flowering plants,…

  6. Teaching Very Large Classes

    Science.gov (United States)

    DeRogatis, Amy; Honerkamp, Kenneth; McDaniel, Justin; Medine, Carolyn; Nyitray, Vivian-Lee; Pearson, Thomas

    2014-01-01

    The editor of "Teaching Theology and Religion" facilitated this reflective conversation with five teachers who have extensive experience and success teaching extremely large classes (150 students or more). In the course of the conversation these professors exchange and analyze the effectiveness of several active learning strategies they…

  7. Adeus à classe trabalhadora?

    Directory of Open Access Journals (Sweden)

    Geoff Eley

    2013-12-01

    Full Text Available No início da década de 1980, a política centrada em classes da tradição socialista estava em crise, e comentadores importantes adotaram tons apocalípticos. No final da década, a esquerda permanecia profundamente dividida entre os advogados da mudança e os defensores da fé. Em meados dos anos 1990, os primeiros tinham, de modo geral, ganhado a batalha. O artigo busca apresentar essa mudança contemporânea não como a 'morte da classe', mas como o desa­parecimento de um tipo particular de ­sociedade de classes, marcado pelo ­processo de formação da classe trabalhadora entre os anos 1880 e 1940 e pelo alinhamento político daí resultante, atingindo seu apogeu na construção social-democrata do acordo do pós-guerra. Quando mudanças de longo prazo na economia se combinaram com o ataque ao keynesianismo na política de recessão a partir de meados da década de 1970, a unidade da classe trabalhadora deixou de estar disponível da forma antiga e bastante utilizada, como o terreno natural da política de esquerda. Enquanto uma coletividade dominante da classe trabalhadora entrou em declínio, outra se corporificou de modo lento e desigual para tomar o lugar daquela. Mas a unidade operacional dessa nova agregação da classe trabalhadora ainda está, em grande parte, em formação. Para recuperar a eficácia política da tradição socialista, alguma nova visão de agência política coletiva será necessária, uma visão imaginativamente ajustada às condições emergentes da produção e acumulação capitalista no início do século XXI.

  8. Genomic characterization of methanomicrobiales reveals three classes of methanogens.

    Directory of Open Access Journals (Sweden)

    Iain Anderson

    Full Text Available BACKGROUND: Methanomicrobiales is the least studied order of methanogens. While these organisms appear to be more closely related to the Methanosarcinales in ribosomal-based phylogenetic analyses, they are metabolically more similar to Class I methanogens. METHODOLOGY/PRINCIPAL FINDINGS: In order to improve our understanding of this lineage, we have completely sequenced the genomes of two members of this order, Methanocorpusculum labreanum Z and Methanoculleus marisnigri JR1, and compared them with the genome of a third, Methanospirillum hungatei JF-1. Similar to Class I methanogens, Methanomicrobiales use a partial reductive citric acid cycle for 2-oxoglutarate biosynthesis, and they have the Eha energy-converting hydrogenase. In common with Methanosarcinales, Methanomicrobiales possess the Ech hydrogenase and at least some of them may couple formylmethanofuran formation and heterodisulfide reduction to transmembrane ion gradients. Uniquely, M. labreanum and M. hungatei contain hydrogenases similar to the Pyrococcus furiosus Mbh hydrogenase, and all three Methanomicrobiales have anti-sigma factor and anti-anti-sigma factor regulatory proteins not found in other methanogens. Phylogenetic analysis based on seven core proteins of methanogenesis and cofactor biosynthesis places the Methanomicrobiales equidistant from Class I methanogens and Methanosarcinales. CONCLUSIONS/SIGNIFICANCE: Our results indicate that Methanomicrobiales, rather than being similar to Class I methanogens or Methanomicrobiales, share some features of both and have some unique properties. We find that there are three distinct classes of methanogens: the Class I methanogens, the Methanomicrobiales (Class II, and the Methanosarcinales (Class III.

  9. Genomic Characterization of Methanomicrobiales Reveals Three Classes of Methanogens

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, Iain; Ulrich, Luke E.; Lupa, Boguslaw; Susanti, Dwi; Porat, Iris; Hooper, Sean D.; Lykidis, Athanasios; Sieprawska-Lupa, Magdalena; Dharmarajan, Lakshmi; Goltsman, Eugene; Lapidus, Alla; Saunders, Elizabeth; Han, Cliff; Land, Miriam; Lucas, Susan; Mukhopadhyay, Biswarup; Whitman, William B.; Woese, Carl; Bristow, James; Kyrpides, Nikos

    2009-05-01

    Methanomicrobiales is the least studied order of methanogens. While these organisms appear to be more closely related to the Methanosarcinales in ribosomal-based phylogenetic analyses, they are metabolically more similar to Class I methanogens. In order to improve our understanding of this lineage, we have completely sequenced the genomes of two members of this order, Methanocorpusculum labreanum Z and Methanoculleus marisnigri JR1, and compared them with the genome of a third, Methanospirillum hungatei JF-1. Similar to Class I methanogens, Methanomicrobiales use a partial reductive citric acid cycle for 2-oxoglutarate biosynthesis, and they have the Eha energy-converting hydrogenase. In common with Methanosarcinales, Methanomicrobiales possess the Ech hydrogenase and at least some of them may couple formylmethanofuran formation and heterodisulfide reduction to transmembrane ion gradients. Uniquely, M. labreanum and M. hungatei contain hydrogenases similar to the Pyrococcus furiosus Mbh hydrogenase, and all three Methanomicrobiales have anti-sigma factor and anti-anti-sigma factor regulatory proteins not found in other methanogens. Phylogenetic analysis based on seven core proteins of methanogenesis and cofactor biosynthesis places the Methanomicrobiales equidistant from Class I methanogens and Methanosarcinales. Our results indicate that Methanomicrobiales, rather than being similar to Class I methanogens or Methanomicrobiales, share some features of both and have some unique properties. We find that there are three distinct classes of methanogens: the Class I methanogens, the Methanomicrobiales (Class II), and the Methanosarcinales (Class III).

  10. Juvenile idiopathic arthritis (JIA): a screening study to measure class II skeletal pattern, TMJ PDS and use of systemic corticosteroids.

    LENUS (Irish Health Repository)

    Mandall, Nicky A

    2010-03-01

    To screen patients with oligoarticular and polyarticular forms of Juvenile Idiopathic Arthritis (JIA) to determine (i) the severity of their class II skeletal pattern; (ii) temporomandibular joint signs and symptoms and (iii) use of systemic corticosteroids.

  11. Extraction of Am(III) and Eu(III) by 2,6-di(5,6-dialkyl-1,2,4-triazine-3-yl)pyridines

    International Nuclear Information System (INIS)

    It had previously been shown that 2,6-di(5,6-dialkyl-1,2,4-triazine-3-yl)pyridines extract Am(III) selectively over Eu(III), giving a separation factor of 100-120. In this work a more detailed study of the distribution equilibria was made. If not given otherwise, 2,6-di(5,6-di-propyl-1,2,4-triazine-3-yl)pyridine (=B) was taken as a representative of the title extractant class and a mixture of branched alkanes (TPH) modified with 2-ethyl-1-hexanol was taken as a diluent. Since Am(III) and Eu(III) (=M) are extracted as complexes of the type M(NO3)33B, their distribution ratios increase strongly with the activity of nitrate ions in the aqueous phase and the concentration of the extractant in the organic phase. The distribution ratios of the metals are suppressed in the presence of macro amounts of Eu(III), due to lowering the free extractant concentration as the solvent loading is not negligible, but the Am(III)/Eu(III) separation factor remains unchanged. The extraction of Am(III) and Eu(III) is little changed if 1-octanol is taken as a TPH modifier instead of 2-ethyl-1-hexanol, and the highest distribution ratios are attained at 10-20 vol% alcohol. The optimum concentration of the alcohol is 20 vol%, giving appropriate solubilization of the extractant in the mixed diluent. Higher distribution ratios are obtained in the presence of 1-butanol which, however, solubilizes the extractant less effectively than the octanols. Both the extraction efficiency and the Am(III)/Eu(III) separation factor decrease in the following order of diluents (each modified by 20 vol% 2-ethyl-1-hexanol): TPH > cyclohexane > 2-methyl-4-pentanone > 2-ethylhexyl acetate > chloro-benzene > benzene > xylene. (author)

  12. Spectrophotometric and pH-Metric Studies of Ce(III, Dy(III, Gd(III,Yb(III and Pr(III Metal Complexes with Rifampicin

    Directory of Open Access Journals (Sweden)

    A. N. Sonar

    2011-01-01

    Full Text Available The metal-ligand and proton-ligand stability constant of Ce(III, Dy(III, Gd(III,Yb(III and Pr(III metals with substituted heterocyclic drug (Rifampicin were determined at various ionic strength by pH metric titration. NaClO4 was used to maintain ionic strength of solution. The results obtained were extrapolated to the zero ionic strength using an equation with one individual parameter. The thermodynamic stability constant of the complexes were also calculated. The formation of complexes has been studied by Job’s method. The results obtained were of stability constants by pH metric method is confirmed by Job’s method.

  13. World Class Facilities Management

    DEFF Research Database (Denmark)

    Malmstrøm, Ole Emil; Jensen, Per Anker

    2013-01-01

    Alle der med entusiasme arbejder med Facilities Management drømmer om at levere World Class. DFM drømmer om at skabe rammer og baggrund for, at vi i Danmark kan bryste os at være blandt de førende på verdensplan. Her samles op på, hvor tæt vi er på at nå drømmemålet.......Alle der med entusiasme arbejder med Facilities Management drømmer om at levere World Class. DFM drømmer om at skabe rammer og baggrund for, at vi i Danmark kan bryste os at være blandt de førende på verdensplan. Her samles op på, hvor tæt vi er på at nå drømmemålet....

  14. Graphics Gems III IBM version

    CERN Document Server

    Kirk, David

    1994-01-01

    This sequel to Graphics Gems (Academic Press, 1990), and Graphics Gems II (Academic Press, 1991) is a practical collection of computer graphics programming tools and techniques. Graphics Gems III contains a larger percentage of gems related to modeling and rendering, particularly lighting and shading. This new edition also covers image processing, numerical and programming techniques, modeling and transformations, 2D and 3D geometry and algorithms,ray tracing and radiosity, rendering, and more clever new tools and tricks for graphics programming. Volume III also includes a

  15. Trigger efficiencies at BES III

    CERN Document Server

    Berger, N; Liu, Z A; Jin, D P; Xu, H; Gong, W X; Wang, K; Cao, G F

    2010-01-01

    Trigger efficiencies at BES III were determined for both the J/psi and psi' data taking of 2009. Both dedicated runs and physics datasets are used; efficiencies are presented for Bhabha-scattering events, generic hadronic decay events involving charged tracks, dimuon events and psi' -> pi+pi-J/psi, J/psi -> l+l- events (l an electron or muon). The efficiencies are found to lie well above 99% for all relevant physics cases, thus fulfilling the BES III design specifications.

  16. Theory of ferromagnetic (III,Mn)V semiconductors

    Science.gov (United States)

    Jungwirth, T.; Sinova, Jairo; Mašek, J.; Kučera, J.; MacDonald, A. H.

    2006-07-01

    The body of research on (III,Mn)V diluted magnetic semiconductors (DMSs) initiated during the 1990s has concentrated on three major fronts: (i) the microscopic origins and fundamental physics of the ferromagnetism that occurs in these systems, (ii) the materials science of growth and defects, and (iii) the development of spintronic devices with new functionalities. This article reviews the current status of the field, concentrating on the first two, more mature research directions. From the fundamental point of view, (Ga,Mn)As and several other (III,Mn)V DMSs are now regarded as textbook examples of a rare class of robust ferromagnets with dilute magnetic moments coupled by delocalized charge carriers. Both local moments and itinerant holes are provided by Mn, which makes the systems particularly favorable for realizing this unusual ordered state. Advances in growth and postgrowth-treatment techniques have played a central role in the field, often pushing the limits of dilute Mn-moment densities and the uniformity and purity of materials far beyond those allowed by equilibrium thermodynamics. In (III,Mn)V compounds, material quality and magnetic properties are intimately connected. This review focuses on the theoretical understanding of the origins of ferromagnetism and basic structural, magnetic, magnetotransport, and magneto-optical characteristics of simple (III,Mn)V epilayers, with the main emphasis on (Ga,Mn)As. Conclusions are arrived at based on an extensive literature covering results of complementary ab initio and effective Hamiltonian computational techniques, and on comparisons between theory and experiment. The applicability of ferromagnetic semiconductors in microelectronic technologies requires increasing Curie temperatures from the current record of 173K in (Ga,Mn)As epilayers to above room temperature. The issue of whether or not this is a realistic expectation for (III,Mn)V DMSs is a central question in the field and motivates many of the analyses

  17. Class Attendance and Academic Performance among Spanish Economics Students

    OpenAIRE

    Velasco, Carlos; D´Addazio, Rosaria; Andrietti, Vincenzo

    2008-01-01

    This paper presents new evidence on the effects of class attendance on academic performance. We analyse survey data collected for an Introductory Econometrics Course at the Facultad de Ciencias Sociales y Jurídicas of Universidad Carlos III de Madrid, matched to administrative data. Using OLS-proxy regressions to control for unobservable student characteristics potentially correlated with attendance, we find a positive and significant effect of attendance on academic performance. However, the...

  18. Moebius综合征患者牙颌面特征及正颌正畸治疗远期疗效评价%Clinical feature of dentofacial deformities of Moebius syndrome patients and long-term follow-up after joint or thognathic -orthodontic treatment

    Institute of Scientific and Technical Information of China (English)

    蔡鸣; 沈国芳; 房兵; 朱敏; 毛丽霞; 聂萍

    2012-01-01

    目的:评价正颌正畸联合治疗Moebius综合征患者的牙颌畸形的远期疗效.方法:Moebius综合征患者3例,经正颌正畸联合会诊制订治疗计划,按照术前正畸、正颌手术、术后正畸的联合治疗模式进行系统治疗,随访1~6a.结果:Moebius综合征患者的牙颌特征主要表现为严重的骨性开(牙合)畸形.对于牙颌畸形的治疗,主要是通过正颌正畸联合治疗进行矫正,但由于升颌肌群功能障碍,开(牙合)矫正的复发倾向比较明显,需要术后密切随访治疗.结论:正颌正畸联合治疗能够矫正Moebius综合征患者严重的骨性开(牙合)畸形,正颌手术后的长期随访对防止开(牙合)的复发具有重要意义.%PURPOSE: To evaluate the dentofacial manifestation and long term result after orthognathic-orthodontics treatment of Moebius patient. METHODS: A joint orthodontic and orthognathic consultation was performed on 3 moebius syndrome cases. Peri-surgical orthodontic treatment combined with orthognathic surgery and long term follow up (1~6 years) was carried out. RESULTS: A severe skeletal open bite was recognized in Moebius syndrome case. Orthodontic combined with orthognathic surgery treatment result in a normal occlusal relationship. A potential post-surgical recurrence was ascribed to functional insufficiency of ascend masticatory muscle. CONCLUSION: Combined orthodontic and orthognathic treatment could correct the skeletal open bite of Moebius syndrome. Routinely postsurgical follow-up was necessary to maintain the long term result. Supported by National Natural Science Foundation of China (81100793), Shanghai Shenkang Research Fund (SHCD12010205) and Program for Innovative Research Team of Shanghai Municipal Education Commission.

  19. CERN Technical Training 2004: New Short Course III (SC III) on Microsoft Outlook - Meetings and Delegation

    CERN Multimedia

    Monique Duval

    2004-01-01

    The CERN Technical Training programme is now proposing a new format for courses on Microsoft Outlook. Three two-hours Short Courses (SC) cover basic and advanced functionalities of the recommended mail client for email at CERN. Each module can be followed independently. The next scheduled session of the 3rd module will take place as follows: Outlook (SC III): Meetings and Delegation. Next session: 9.11.2004 (14:00-16:00) SC III will cover how to organise and manage meetings, work with meeting requests, share tasks, and use email and calendar delegation. The number of participants to each session is limited to 8. The instructor is English-French bilingual, and she will be available some time after each session to answer specific questions, or provide further explanations following demand. The cost of attending any SC module on Outlook is 70.- CHF. The above session will be confirmed if there are enough participants, and the attendance costs will be lower in case of a full class. If you are interested in...

  20. Group III metabotropic glutamate receptors and drug addiction.

    Science.gov (United States)

    Mao, Limin; Guo, Minglei; Jin, Daozhong; Xue, Bing; Wang, John Q

    2013-12-01

    Neuroadaptations of glutamatergic transmission in the limbic reward circuitry are linked to persistent drug addiction. Accumulating data have demonstrated roles of ionotropic glutamate receptors and group I and II metabotropic glutamate receptors (mGluRs) in this event. Emerging evidence also identifies Gαi/o-coupled group III mGluRs (mGluR4/7/8 subtypes enriched in the limbic system) as direct substrates of drugs of abuse and active regulators of drug action. Auto- and heteroreceptors of mGluR4/7/8 reside predominantly on nerve terminals of glutamatergic corticostriatal and GABAergic striatopallidal pathways, respectively. These presynaptic receptors regulate basal and/or phasic release of respective transmitters to maintain basal ganglia homeostasis. In response to operant administration of common addictive drugs, such as psychostimulants (cocaine and amphetamine), alcohol and opiates, limbic group III mGluRs undergo drastic adaptations to contribute to the enduring remodeling of excitatory synapses and to usually suppress drug seeking behavior. As a result, a loss-of-function mutation (knockout) of individual group III receptor subtypes often promotes drug seeking. This review summarizes the data from recent studies on three group III receptor subtypes (mGluR4/7/8) expressed in the basal ganglia and analyzes their roles in the regulation of dopamine and glutamate signaling in the striatum and their participation in the addictive properties of three major classes of drugs (psychostimulants, alcohol, and opiates). PMID:24078068

  1. Class Participation: Promoting In-Class Student Engagement

    Science.gov (United States)

    O'Connor, Kevin J.

    2013-01-01

    Class participation has long been valued by faculty members interested in engaging students in the learning process. This paper discusses class participation and shares participation techniques that promote active student engagement during class meetings. Emphasis is placed on techniques that invite a larger number of students into a course's…

  2. Class Action and Class Settlement in a European Perspective

    DEFF Research Database (Denmark)

    Werlauff, Erik

    2013-01-01

    The article analyses the options for introducing common European rules on class action lawsuits with an opt-out-model in individual cases. An analysis is made of how the risks of misuse of class actions can be prevented. The article considers the Dutch rules on class settlements (the WCAM procedure...

  3. Flora Malesiana, Series III: Bryophyta

    NARCIS (Netherlands)

    Wijk, van der R.

    1951-01-01

    Scope, organization, and purpose of Series III, Flora Malesiana (Musci and Hepaticae) are explained. Collaboration is asked on the following points: (a) To collect Mosses and Hepaticae in Malaysia and to add extensive and detailed data to the specimens (directions available on application to the Edi

  4. Organometallic neptunium(III) complexes.

    Science.gov (United States)

    Dutkiewicz, Michał S; Farnaby, Joy H; Apostolidis, Christos; Colineau, Eric; Walter, Olaf; Magnani, Nicola; Gardiner, Michael G; Love, Jason B; Kaltsoyannis, Nikolas; Caciuffo, Roberto; Arnold, Polly L

    2016-08-01

    Studies of transuranic organometallic complexes provide a particularly valuable insight into covalent contributions to the metal-ligand bonding, in which the subtle differences between the transuranium actinide ions and their lighter lanthanide counterparts are of fundamental importance for the effective remediation of nuclear waste. Unlike the organometallic chemistry of uranium, which has focused strongly on U(III) and has seen some spectacular advances, that of the transuranics is significantly technically more challenging and has remained dormant. In the case of neptunium, it is limited mainly to Np(IV). Here we report the synthesis of three new Np(III) organometallic compounds and the characterization of their molecular and electronic structures. These studies suggest that Np(III) complexes could act as single-molecule magnets, and that the lower oxidation state of Np(II) is chemically accessible. In comparison with lanthanide analogues, significant d- and f-electron contributions to key Np(III) orbitals are observed, which shows that fundamental neptunium organometallic chemistry can provide new insights into the behaviour of f-elements.

  5. An "expanded" class perspective

    DEFF Research Database (Denmark)

    Steur, Luisa Johanna

    2014-01-01

    Following the police raid on the ‘Muthanga’ land occupation by Adivasi (‘indigenous’) activists in Kerala, India, in February 2003, intense public debate erupted about the fate of Adivasis in this ‘model’ development state. Most commentators saw the land occupation either as the fight...... capitalist relations, the exact social processes under which they were having to make a living, and what had only recently—and still largely ambiguously—made them ready to identify themselves politically as ‘Adivasi’. Demonstrating the usefulness of ethnographic curiosity driven by an ‘expanded’ class...

  6. The Class of '34

    OpenAIRE

    Cairney, Richard

    1995-01-01

    The Great Depression raged, governments were beleaguered, the unemployment rate stood at 30%, scurvy stalked the poor and no one was immune to contagious diseases such as scarlet fever, polio and measles when the University of Alberta School of Medicine's Class of '34 graduated. For four alumni who recently gathered in Edmonton—Drs. Morley Hodgson, Melvin Gaudin, John McLurg and Edmund Cairns—their 60th-anniversary reunion was a time to recall the changes they have witnessed in medicine, incl...

  7. Mining Java Class Naming Conventions

    OpenAIRE

    Butler, Simon; Wermelinger, Michel; Yu, Yijun; Sharp, Helen

    2011-01-01

    Class names represent the concepts implemented in object-oriented source code and are key elements in program comprehension and, thus, software maintenance. Programming conventions often state that class names should be noun-phrases, but there is little further guidance for developers on the composition of class names. Other researchers have observed that the majority of Java class identifier names are composed of one or more nouns preceded, optionally, by one or more adjectives. However, no ...

  8. Reconciling Virtual Classes with Genericity

    DEFF Research Database (Denmark)

    Ernst, Erik

    2006-01-01

    classes. As a result, a kind of type parameters have been introduced, but they are simple and only used where they excel. Conversely, final definitions of virtual classes have been re- moved from the language, thus making virtual classes more flexible. The result- ing language presents a clearer and more...

  9. Team Learning in Large Classes.

    Science.gov (United States)

    Roueche, Suanne D., Ed.

    1984-01-01

    Information and suggestions are provided on the use of team learning in large college classes. Introductory material discusses the negative cycle of student-teacher interaction that may be provoked by large classes, and the use of permanent, heterogeneous, six- or seven-member student learning groups as the central focus of class activity as a…

  10. C3 functionalization of indolizines via In(iii)-catalyzed three-component reaction.

    Science.gov (United States)

    Jung, Youngeun; Kim, Ikyon

    2015-12-01

    Post-functionalization at the C3 position of indolizines via In(iii)-catalyzed three-component coupling reaction with amines and aldehydes allowed rapid access to a new class of indolizines with diverse functional groups at the C3 position in good to excellent yields. PMID:26380932

  11. Search for the magnetic field of the O7.5 III star ξ Persei

    NARCIS (Netherlands)

    H.F. Henrichs; R.S. Schnerr; J.A. de Jong; L. Kaper; J.F. Donati; C. Catala

    2008-01-01

    Cyclical wind variability is an ubiquitous but as yet unexplained feature among OB stars. The O7.5 III(n)((f)) star ξ Persei is the brightest representative of this class on the Northern hemisphere. As its prominent cyclical wind properties vary on a rotational time scale (2 or 4 days) the star has

  12. A Molecular Predictor Reassesses Classification of Human Grade II/III Gliomas.

    Directory of Open Access Journals (Sweden)

    Thierry Rème

    Full Text Available Diffuse gliomas are incurable brain tumors divided in 3 WHO grades (II; III; IV based on histological criteria. Grade II/III gliomas are clinically very heterogeneous and their prognosis somewhat unpredictable, preventing definition of appropriate treatment. On a cohort of 65 grade II/III glioma patients, a QPCR-based approach allowed selection of a biologically relevant gene list from which a gene signature significantly correlated to overall survival was extracted. This signature clustered the training cohort into two classes of low and high risk of progression and death, and similarly clustered two external independent test cohorts of 104 and 73 grade II/III patients. A 22-gene class predictor of the training clusters optimally distinguished poor from good prognosis patients (median survival of 13-20 months versus over 6 years in the validation cohorts. This classification was stronger at predicting outcome than the WHO grade II/III classification (P≤2.8E-10 versus 0.018. When compared to other prognosis factors (histological subtype and genetic abnormalities in a multivariate analysis, the 22-gene predictor remained significantly associated with overall survival. Early prediction of high risk patients (3% of WHO grade II, and low risk patients (29% of WHO grade III in clinical routine will allow the development of more appropriate follow-up and treatments.

  13. Organic / IV, III-V Semiconductor Hybrid Solar Cells

    Directory of Open Access Journals (Sweden)

    Pang-Leen Ong

    2010-03-01

    Full Text Available We present a review of the emerging class of hybrid solar cells based on organic-semiconductor (Group IV, III-V, nanocomposites, which states separately from dye synthesized, polymer-metal oxides and organic-inorganic (Group II-VI nanocomposite photovoltaics. The structure of such hybrid cell comprises of an organic active material (p-type deposited by coating, printing or spraying technique on the surface of bulk or nanostructured semiconductor (n-type forming a heterojunction between the two materials. Organic components include various photosensitive monomers (e.g., phtalocyanines or porphyrines, conjugated polymers, and carbon nanotubes. Mechanisms of the charge separation at the interface and their transport are discussed. Also, perspectives on the future development of such hybrid cells and comparative analysis with other classes of photovoltaics of third generation are presented.

  14. Class Discovery in Galaxy Classification

    CERN Document Server

    Bazell, D; Bazell, David; Miller, David J.

    2004-01-01

    In recent years, automated, supervised classification techniques have been fruitfully applied to labeling and organizing large astronomical databases. These methods require off-line classifier training, based on labeled examples from each of the (known) object classes. In practice, only a small batch of labeled examples, hand-labeled by a human expert, may be available for training. Moreover, there may be no labeled examples for some classes present in the data, i.e. the database may contain several unknown classes. Unknown classes may be present due to 1) uncertainty in or lack of knowledge of the measurement process, 2) an inability to adequately ``survey'' a massive database to assess its content (classes), and/or 3) an incomplete scientific hypothesis. In recent work, new class discovery in mixed labeled/unlabeled data was formally posed, with a proposed solution based on mixture models. In this work we investigate this approach, propose a competing technique suitable for class discovery in neural network...

  15. Network class superposition analyses.

    Science.gov (United States)

    Pearson, Carl A B; Zeng, Chen; Simha, Rahul

    2013-01-01

    Networks are often used to understand a whole system by modeling the interactions among its pieces. Examples include biomolecules in a cell interacting to provide some primary function, or species in an environment forming a stable community. However, these interactions are often unknown; instead, the pieces' dynamic states are known, and network structure must be inferred. Because observed function may be explained by many different networks (e.g., ≈ 10(30) for the yeast cell cycle process), considering dynamics beyond this primary function means picking a single network or suitable sample: measuring over all networks exhibiting the primary function is computationally infeasible. We circumvent that obstacle by calculating the network class ensemble. We represent the ensemble by a stochastic matrix T, which is a transition-by-transition superposition of the system dynamics for each member of the class. We present concrete results for T derived from boolean time series dynamics on networks obeying the Strong Inhibition rule, by applying T to several traditional questions about network dynamics. We show that the distribution of the number of point attractors can be accurately estimated with T. We show how to generate Derrida plots based on T. We show that T-based Shannon entropy outperforms other methods at selecting experiments to further narrow the network structure. We also outline an experimental test of predictions based on T. We motivate all of these results in terms of a popular molecular biology boolean network model for the yeast cell cycle, but the methods and analyses we introduce are general. We conclude with open questions for T, for example, application to other models, computational considerations when scaling up to larger systems, and other potential analyses. PMID:23565141

  16. The Negotiation of Basel III

    DEFF Research Database (Denmark)

    Just, Sine Nørholm

    2015-01-01

    While the Basel Accords of 1988 and 2004 (Basel I and Basel II) ostensibly set out to regulate bank risk at the international level, they were effectively in the grip of neoliberal beliefs in the self-regulating potential of free markets. In 2009–2011, the Basel Accords were revised once more wit...... agency, the empirical argument is substantiated through textual–intertextual analysis of the rhetorical circulation of affective signs in the Basel III negotiations....

  17. Mechatronic systems and materials III

    CERN Document Server

    Gosiewski, Zdzislaw

    2009-01-01

    This very interesting volume is divided into 24 sections; each of which covers, in detail, one aspect of the subject-matter: I. Industrial robots; II. Microrobotics; III. Mobile robots; IV. Teleoperation, telerobotics, teleoperated semi-autonomous systems; V. Sensors and actuators in mechatronics; VI. Control of mechatronic systems; VII. Analysis of vibration and deformation; VIII. Optimization, optimal design; IX. Integrated diagnostics; X. Failure analysis; XI. Tribology in mechatronic systems; XII. Analysis of signals; XIII. Measurement techniques; XIV. Multifunctional and smart materials;

  18. Antithrombin III and the nephrotic syndrome.

    Science.gov (United States)

    Jørgensen, K A; Stoffersen, E

    1979-05-01

    Plasma and urinary antithrombin III (AT-III) was measured in 15 cases of nephrotic syndrome. Plasma AT-III correlated well with serum albumin, but poorly with proteinuria, whereas urinary AT-III correlated well to proteinuria. The plasma AT-III level had a mean similar to 25 healthy controls, but the range was significantly wider. A case with nephrotic syndrome and left renal vein thrombosis is reported. The urinary output of AT-III rose and the plasma level fell with the activity of the disease. Although AT-III and albumin have similar molecule weight, their renal clearance was found to be different. It is suggested that urinary loss of AT-III plays a role in the hypercoagulable state sometimes found in the nephrotic syndrome.

  19. Glycosaminoglycans and mucopolysaccharidosis type III.

    Science.gov (United States)

    Jakobkiewicz-Banecka, Joanna; Gabig-Ciminska, Magdalena; Kloska, Anna; Malinowska, Marcelina; Piotrowska, Ewa; Banecka-Majkutewicz, Zyta; Banecki, Bogdan; Wegrzyn, Alicja; Wegrzyn, Grzegorz

    2016-01-01

    Mucopolysaccharidosis type III (MPS III), or Sanfilippo syndrome, is a lysosomal storage disease in which heparan sulfate is accumulated in lysosomes, as well as outside of cells, as the primary storage material. This disease is a complex of four conditions caused by dysfunctions of one of genes coding for lysosomal enzymes involved in degradation of heparan sulfate: SGSH (coding for heparan N-sulfatase) - causing MPS IIIA, NAGLU (coding for alpha-N-acetylglucosaminidase) - causing MPS IIIB, HGSNAT (coding for acetyl CoA alpha-glucosaminide acetyltransferase) - causing MPS IIIC), and GNS (coding for N-acetylglucosamine-6-sulfatase) - causing MPS IIID. The primary storage is responsible for some disease symptoms, but other arise as a result of secondary storage, including glycosphingolipids, and subsequent processes, like oxidative stress and neuroinflammation. Central nervous system is predominantly affected in all subtypes of MPS III. Heparan sulfate and its derivatives are the most commonly used biomarkers for diagnosis and prediction procedures. Currently, there is no therapy for Sanfilippo syndrome, however, clinical trials are ongoing for enzyme replacement therapy, gene therapy and substrate reduction therapy (particularly gene expression-targeted isoflavone therapy). PMID:27100513

  20. Organometallic neptunium(III) complexes

    Science.gov (United States)

    Dutkiewicz, Michał S.; Farnaby, Joy H.; Apostolidis, Christos; Colineau, Eric; Walter, Olaf; Magnani, Nicola; Gardiner, Michael G.; Love, Jason B.; Kaltsoyannis, Nikolas; Caciuffo, Roberto; Arnold, Polly L.

    2016-08-01

    Studies of transuranic organometallic complexes provide a particularly valuable insight into covalent contributions to the metal–ligand bonding, in which the subtle differences between the transuranium actinide ions and their lighter lanthanide counterparts are of fundamental importance for the effective remediation of nuclear waste. Unlike the organometallic chemistry of uranium, which has focused strongly on UIII and has seen some spectacular advances, that of the transuranics is significantly technically more challenging and has remained dormant. In the case of neptunium, it is limited mainly to NpIV. Here we report the synthesis of three new NpIII organometallic compounds and the characterization of their molecular and electronic structures. These studies suggest that NpIII complexes could act as single-molecule magnets, and that the lower oxidation state of NpII is chemically accessible. In comparison with lanthanide analogues, significant d- and f-electron contributions to key NpIII orbitals are observed, which shows that fundamental neptunium organometallic chemistry can provide new insights into the behaviour of f-elements.

  1. Solvent extraction of lanthanide ions with 1-phenyl-3-methyl-4-benzoyl-pyrazolone-5 (HPMBP), III: extraction of gadolinium(III), terbium(III), dysprosium(III), holmium(III), and thulium(III) by HPMBP from aqueous solutions

    International Nuclear Information System (INIS)

    The solvent extraction behaviour of Gd(III), Tb(III), Dy(III), Ho(III), and Tm(III) has been investigated using 1-phenyl-3-methyl-4-benzoyl-pyrazolone-5 (HPMBP or HL) in carbon tetrachloride as the extractant. Depending on the concentration of HPMBP in the organic phase the chelates LnL3[Ln(III)=Gd, Tb, Dy, Ho, Tm] and adducts LnL3.HL[Ln(III)=Gd, Tb, Dy, Ho] were extracted. The extraction equilibrium constants (Kex3 or Kex4) for the formation of LnL3 or LnL3.HL and the two-phase stability constants of the chelates or adducts (β3x, β4x) have been evaluated. (authors)

  2. Antithrombin III for critically ill patients

    DEFF Research Database (Denmark)

    Afshari, Arash; Wetterslev, Jørn; Brok, Jesper Sune;

    2008-01-01

    Critical illness is associated with uncontrolled inflammation and vascular damage which can result in multiple organ failure and death. Antithrombin III (AT III) is an anticoagulant with anti-inflammatory properties but the efficacy and any harmful effects of AT III supplementation in critically ...

  3. 21 CFR 1308.13 - Schedule III.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Schedule III. 1308.13 Section 1308.13 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE SCHEDULES OF CONTROLLED SUBSTANCES Schedules § 1308.13 Schedule III. (a) Schedule III shall consist of the drugs and other substances,...

  4. Organizing MHC Class II Presentation

    Directory of Open Access Journals (Sweden)

    David R Fooksman

    2014-04-01

    Full Text Available Major histocompatibility complex (MHC class II molecules are ligands for CD4+ T cells and are critical for initiating the adaptive immune response. This review is focused on what is currently known about MHC class II organization at the plasma membrane of antigen presenting cells and how this affects antigen presentation to T cells. The organization and diffusion of class II molecules have been measured by a variety of biochemical and microscopic techniques. Membrane lipids and other proteins have been implicated in MHC class II organization and function. However, when compared with the organization of MHC class I or TCR complexes, much less is known about MHC class II. Since clustering of T cell receptors occurs during activation, the organization of MHC molecules prior to recognition and during synapse formation may be critical for antigen presentation.

  5. PENGGUNAAN INCLINED BITE PLANE SEBAGAI ALAT BANTU UNTUK KOREKSI GIGITAN SILANG ANTERIOR PADA KASUS MALOKLUSI KLAS III SKELETAL

    Directory of Open Access Journals (Sweden)

    Amutavia P. Artsianti P.

    2015-08-01

    Full Text Available Anterior crossbite occurs in children and adult. This anterior crossbite could be a dental (pseudo class III or a skeletal class III malocclusions. A 15 year old young female came to orthodontic clinic RSGM FKGUI with maxillary dental crowding which canines were more protruded. The dental of mandible were more protruded than maxillary dental. The clinical examination, anamnesis, functional analyses and cephalometric evaluation and model study showed that it was a skeletal class III malocclusion with maxillary skeletal retrusion. To treat the anterior crossbite, the inclined bite plane is used for 2 weeks and followed by fixed appliance. After 2 month treatment, the anterior crossbite is resolved. The result of cephalometric evaluation showed that the use of inclined bite plane as a tool is quite effective to resolve this case.

  6. Population III stars around the Milky Way

    OpenAIRE

    Komiya, Yutaka; Suda, Takuma; Fujimoto, Masayuki Y.

    2016-01-01

    We explore the possibility of observing Population III (Pop~III) stars, born of the primordial gas. Pop~III stars with masses below $0.8 M_\\odot$ should survive to date though are not observed yet, but the existence of stars with low metallicity as [Fe/H]$ < -5$ in the Milky Way halo suggests the surface pollution of Pop~III stars with accreted metals from the interstellar gas after birth. In this paper, we investigate the runaway of Pop~III stars from their host mini-halos, considering the e...

  7. Separation of gadolinium(III) and lanthanum(III) by nanofiltration-complexation in aqueous medium

    International Nuclear Information System (INIS)

    A new method is proposed for the separation of gadolinium(III) and lanthanum(III) in aqueous medium by nanofiltration combined with a complexation step. First DTPA was chosen as ligand for a selective Gd(III)/La(III) complexation. Having investigated the influence of three factors (pH, temperature and amount of ligand) for the selective complexation of DTPA towards Gd(III) and La(III), the system is then combined with a nanofiltration separation process to remove 92% of initial Gd(III) and only 12% of initial La. (author)

  8. Experiencing a Flipped Mathematics Class

    OpenAIRE

    Larsen, A. Judy

    2013-01-01

    The flipped classroom is an old concept that has recently been redefined through the emergence of new technologies that allow teachers to deliver content out of class time. As such, various approaches for implementation exist. Most prominently, teachers are able to use class time in a student-centered manner, which allows students to experience the classroom in diverse ways. This study focuses on describing these experiences in a particular flipped adult upgrading mathematics class. Students ...

  9. Class Differences in Cohabitation Processes

    OpenAIRE

    Sassler, Sharon; Miller, Amanda J.

    2011-01-01

    Despite the burgeoning cohabitation literature, research has failed to examine social class variation in processes of forming and advancing such unions. Drawing upon in-depth interviews with 122 working- and middle-class cohabitors, we examine the duration between dating and moving in together, reasons for cohabiting, and subsequent plans. Transitions to cohabitation are more rapid among the working class. Respondents often cohabited for practical reasons—out of financial necessity, because i...

  10. Optical properties of the Eu(III)-La(III)-complex-doped polyolefine film and rod samples

    Science.gov (United States)

    Pogreb, Roman; Popov, Oleg; Lirtsman, Vlad; Pyshkin, Oleg; Kazachkov, Alexander; Musin, Albina; Finkelshtein, Binyamin; Shmukler, Yuri; Davidov, Dan; Bormashenko, Edward

    2005-04-01

    The work is devoted to luminescent properties of trivalent lanthanide complexes dispersed in thermoplastic host matrices. Polyethylene-based film and polypropylene-based rod both doped with these complexes were manufactured using an extrusion technique. Two kinds of dopants were used: Eu(III)-thenoyltrifluoroacetone-1,10-phenanthroline complex (Eu(III)) and Eu(III)-La(III)-1,10-phenanthroline complex (Eu(III)-La(III)). Comparison was made between these samples regarding absorption, excitation, emission and a lifetime of luminescence. Dependence of emission intensity on the excitation energy was determined. Emission spectra of the films were studied at room and helium temperatures. Optical properties of Eu(III) samples are different from Eu(III)-La(III) samples. Significant difference in spectra of these two types of samples may be attributed to the La(III) action.

  11. Development of demographic norms for four new WAIS-III/WMS-III indexes.

    Science.gov (United States)

    Lange, Rael T; Chelune, Gordon J; Taylor, Michael J; Woodward, Todd S; Heaton, Robert K

    2006-06-01

    Following the publication of the third edition Wechsler scales (i.e., WAIS-III and WMS-III), demographically corrected norms were made available in the form of a computerized scoring program (i.e., WAIS-III/WMS-III/WIAT-II Scoring Assistant). These norms correct for age, gender, ethnicity, and education. Since then, four new indexes have been developed: the WAIS-III General Ability Index, the WMS-III Delayed Memory Index, and the two alternate Immediate and Delayed Memory Indexes. The purpose of this study was to develop demographically corrected norms for the four new indexes using the standardization sample and education oversample from the WAIS-III and WMS-III. These norms were developed using the same methodology as the demographically corrected norms made available in the WAIS-III/WMS-III/WIAT-II Scoring Assistant.

  12. Predicting Acoustics in Class Rooms

    DEFF Research Database (Denmark)

    Christensen, Claus Lynge; Rindel, Jens Holger

    2005-01-01

    Typical class rooms have fairly simple geometries, even so room acoustics in this type of room is difficult to predict using today's room acoustic computer modeling software. The reasons why acoustics of class rooms are harder to predict than acoustics of complicated concert halls might be explai......Typical class rooms have fairly simple geometries, even so room acoustics in this type of room is difficult to predict using today's room acoustic computer modeling software. The reasons why acoustics of class rooms are harder to predict than acoustics of complicated concert halls might...... with surface scattering is presented. Each of the two scattering effects is modeled as frequency dependent functions....

  13. Type Families with Class, Type Classes with Family

    DEFF Research Database (Denmark)

    Serrano, Alejandro; Hage, Jurriaan; Bahr, Patrick

    2015-01-01

    Type classes and type families are key ingredients in Haskell programming. Type classes were introduced to deal with ad-hoc polymorphism, although with the introduction of functional dependencies, their use expanded to type-level programming. Type families also allow encoding type-level functions...

  14. Rare Mycetes of Romania III

    Directory of Open Access Journals (Sweden)

    Denes PAZMANY

    1981-08-01

    Full Text Available New contributions to the knowledges concerning Romania's macromycetes are presented. The 208 species enlisted in the paper are grouped in classes and orders and within these groups the species are enlisted alphabetically. The data refers to species less known to Romania, collected in Transylvania, mostly around Cluj-Napoca. From these Daldinia vernicosa, Pleurotus calyptratus, Agaricus pseudopratensis, Armillariella bulbosa, Clitocybe harmajae and Tubaria hiemalis are rare in all Europe.

  15. Transformational III-V Electronics

    KAUST Repository

    Nour, Maha A.

    2014-04-01

    Flexible electronics using III-V materials for nano-electronics with high electron mobility and optoelectronics with direct band gap are attractive for many applications. This thesis describes a complementary metal oxide semiconductor (CMOS) compatible process for transforming traditional III-V materials based electronics into flexible one. The thesis reports releasing 200 nm of Gallium Arsenide (GaAs) from 200 nm GaAs / 300 nm Aluminum Arsenide (AlAs) stack on GaAs substrate using diluted hydrofluoric acid (HF). This process enables releasing a single top layer compared to peeling off all layers with small sizes at the same time. This is done utilizing a network of release holes that contributes to the better transparency (45 % at 724 nm wavelengths) observed. Fabrication of metal oxide semiconductor capacitor (MOSCAPs) on GaAs is followed by releasing it to have devices on flexible 200 nm GaAs. Similarly, flexible GaSb and InP fabrication process is also reported to transform traditional electronics into large-area flexible electronics.

  16. Differences in serum concentrations of organochlorine compounds by occupational social class in pancreatic cancer

    International Nuclear Information System (INIS)

    Background: The relationships between social factors and body concentrations of environmental chemical agents are unknown in many human populations. Some chemical compounds may play an etiopathogenic role in pancreatic cancer. Objective: To analyze the relationships between occupational social class and serum concentrations of seven selected organochlorine compounds (OCs) in exocrine pancreatic cancer: dichlorodiphenyltrichloroethane (p,p'-DDT), dichlorodiphenyldichloroethene (p,p'-DDE), 3 polychlorinated biphenyls (PCBs), hexachlorobenzene, and β-hexachlorocyclohexane. Methods: Incident cases of exocrine pancreatic cancer were prospectively identified, and interviewed face-to-face during hospital admission (n=135). Serum concentrations of OCs were analyzed by high-resolution gas chromatography with electron-capture detection. Social class was classified according to occupation. Results: Multivariate-adjusted concentrations of all seven compounds were higher in occupational social classes IV-V (the less affluent) than in classes I-II; they were higher as well in class III than in classes I-II for four compounds. Concentrations of six OCs were higher in manual workers than in non-manual workers (p<0.05 for PCBs). Social class explained statistically between 3.7% and 5.7% of the variability in concentrations of PCBs, and 2% or less variability in the other OCs. Conclusions: Concentrations of most OCs were higher in the less affluent occupational social classes. In pancreatic cancer the putative causal role of these persistent organic pollutants may not be independent of social class. There is a need to integrate evidence on the contribution of different social processes and environmental chemical exposures to the etiology of pancreatic and other cancers

  17. The Paradox of Paperless Classes.

    Science.gov (United States)

    Lackie, Paula

    1998-01-01

    Describes paperless classes developed at Carleton College that augment traditional classes by giving students and faculty the ability to share digital course-related materials via the campus computer network. Presents a case study of a managerial economics course, and includes problems with various aspects of the course and solutions. (LRW)

  18. Class Differences in Cohabitation Processes

    Science.gov (United States)

    Sassler, Sharon; Miller, Amanda J.

    2011-01-01

    Despite the burgeoning cohabitation literature, research has failed to examine social class variation in processes of forming and advancing such unions. Drawing upon in-depth interviews with 122 working- and middle-class cohabitors, we examine the duration between dating and moving in together, reasons for cohabiting, and subsequent plans.…

  19. A Touch of...Class!

    Science.gov (United States)

    Netten, Joan W., Ed.

    1984-01-01

    A collection of ideas for class activities in elementary and secondary language classes includes a vocabulary review exercise and games of memory, counting, vocabulary, flashcard tic-tac-toe, dice, trashcans, questioning, and spelling. Some are designed specifically for French. (MSE)

  20. Social Class and the Extracurriculum

    Science.gov (United States)

    Barratt, Will

    2012-01-01

    Social class is a powerful and often unrecognized influence on student participation in the extracurriculum. Spontaneous student-created extracurricular experiences depend on students affiliating and interacting with each other; student social class is a powerful influence on student affiliations. Students tend to exercise consciousness of kind-…

  1. Class, Identity, and Teacher Education

    Science.gov (United States)

    Van Galen, Jane A.

    2010-01-01

    This paper explores the possibilities of working with White, working-class teacher education students to explore the "complex social trajectory" (Reay in Women's Stud Int Forum 20(2):225-233, 1997a, p. 19) of class border crossing as they progress through college. Through analysis of a course that I have developed, "Education and the American…

  2. Dynamic class methods in Java

    OpenAIRE

    Heinlein, Christian

    2005-01-01

    The concept of dynamic class methods in Java, constituting a specialization of a general new programming language concept called dynamic routines, is introduced and applied to a simple case study. Its advantages over standard object-oriented programming techniques including design patterns are demonstrated. Furthermore, an implementation of dynamic class methods as a precompiler-based language extension to Java is described.

  3. Relations among tautological classes revisited

    DEFF Research Database (Denmark)

    Randal-Williams, Oscar

    2012-01-01

    We give a simple generalisation of a theorem of Morita (1989) [10] and [11], which leads to a great number of relations among tautological classes on moduli spaces of Riemann surfaces......We give a simple generalisation of a theorem of Morita (1989) [10] and [11], which leads to a great number of relations among tautological classes on moduli spaces of Riemann surfaces...

  4. Tautological Classes on Projective Towers

    CERN Document Server

    Negut, Andrei

    2011-01-01

    When one has a tower of projective bundles over an algebraic variety and wishes to compute the push-forward of any cohomology class down this tower, one needs to recursively compute the Segre classes corresponding to each level. In this paper, we give a closed combinatorial formula that encodes this recursive procedure.

  5. First class models from linear and nonlinear second class constraints

    CERN Document Server

    Dehghani, Mehdi; Monemzadeh, Majid; Abarghooeinejad, Salman

    2014-01-01

    Two models with linear and nonlinear second class constraints are considered and gauged by embedding in an extended phase space. These models are the free non-relativistic particle on a hyperplane and hyper sphere in configuration space. For the first model we construct its gauged corresponding by the condition of converting second class system to first class one, directly. In contrast the first class system related to the free particle on hyper sphere is derived by the BFT embedding procedure, where its steps are infinite. We give a practical formula for gauging linear and some of the nonlinear second class systems, based on the simplified BFT method. As a result of the gauging two models, we show that in the conversion of second class to the first class constraints the minimum number of phase space degrees of freedom for both systems is a pair of phase space coordinate. This pair for first system is a coordinate and its momentum conjugate, but Poisson structure of embedded non-relativistic particle on hyper...

  6. 78 FR 68992 - Visas: Documentation of Nonimmigrants-Visa Classification; T Visa Class

    Science.gov (United States)

    2013-11-18

    ...: State Department. ACTION: Final rule. SUMMARY: This rule is being promulgated to add a new visa... Section 101(a)(15)(T)(ii)(III) of the Immigration and Nationality Act by adding a derivative ``T'' visa class. The T-6 visa would be available to eligible adult and minor children of a derivative...

  7. Alternative treatment for open bite Class III malocclusion in a child with Williams-Beuren syndrome

    Directory of Open Access Journals (Sweden)

    Giovanni Modesto Vieira

    2015-02-01

    Full Text Available Williams-Beuren syndrome (WBS is a rare genetic condition that affects approximately 1 in every 20,000 - 50,000 live births. WBS children have specific skeletal deformities, dental malformations and rare lingual muscle dysfunction. The need for orthodontic and orthognathic therapy has arisen and has been considered a real clinical challenge even for experienced professionals, once it requires a complex and individualized treatment plan. This study reports a case of orthopedic expansion of the maxilla, in which a modified facial mask was used for protraction of the maxillary complex associated with clockwise rotation of the maxilla. In addition, special considerations about treatment time and orthopedic outcomes are discussed.

  8. A class of discontinuous Petrov–Galerkin methods. Part III: Adaptivity

    KAUST Repository

    Demkowicz, Leszek

    2012-04-01

    We continue our theoretical and numerical study on the Discontinuous Petrov-Galerkin method with optimal test functions in context of 1D and 2D convection-dominated diffusion problems and hp-adaptivity. With a proper choice of the norm for the test space, we prove robustness (uniform stability with respect to the diffusion parameter) and mesh-independence of the energy norm of the FE error for the 1D problem. With hp-adaptivity and a proper scaling of the norms for the test functions, we establish new limits for solving convection-dominated diffusion problems numerically: ε=10 -11 for 1D and ε=10 -7 for 2D problems. The adaptive process is fully automatic and starts with a mesh consisting of few elements only. © 2011 IMACS. Published by Elsevier B.V. All rights reserved.

  9. 21 CFR 807.94 - Format of a class III certification.

    Science.gov (United States)

    2010-04-01

    ..., in my capacity as (position held in company), of (company name), that I have conducted a reasonable... effectiveness problems that have been reported for the (type of device). I further certify that I am aware of the types of problems to which the (type of device) is susceptible and that, to the best of...

  10. An approach to mapping haplotype-specific recombination sites in human MHC class III

    Energy Technology Data Exchange (ETDEWEB)

    Levo, A.; Westman, P.; Partanen, J. [Finnish Red Cross Blood Transfusion Service, Helsinki (Finland)

    1996-12-31

    Studies of the major histocompatibility complex (MHC) in mouse indicate that the recombination sites are not randomly distributed and their occurrence is haplotype-dependent. No data concerning haplotype-specific recombination sites in human are available due to the low number of informative families. To investigate haplotype-specific recombination sites in human MHC, we describe an approach based on identification of recombinant haplotypes derived from one conserved haplotype at the population level. The recombination sites were mapped by comparing polymorphic markers between the recombinant and assumed original haplotypes. We tested this approach on the extended haplotype HLA A3; B47; Bf{sup *}F; C4A{sup *}1; C4B{sup *}Q0; DR7, which is most suitable for this analysis. First, it carries a number of rare markers, and second, the haplotype, albeit rare in the general population, is frequent in patients with 21-hydroxylase (21OH) defect. We observed recombinants derived from this haplotype in patients with 21OH defect. All these haplotypes had the centromeric part (from Bf to DR) identical to the original haplotype, but they differed in HLA A and B. We therefore assumed that they underwent recombinations in the segment that separates the Bf and HLA B genes. Polymorphic markers indicated that all break points mapped to two segments near the TNF locus. This approach makes possible the mapping of preferential recombination sites in different haplotypes. 20 refs., 1 fig., 1 tab.

  11. The Return of Two-Class Medicine—III Effects of Medi-Cal Reform

    OpenAIRE

    Waitzkin, Howard

    1985-01-01

    California's drastic Medi-Cal reforms have created great difficulties in health care for the poor. Patients' clinical problems seldom are apparent in descriptions of changes in public insurance programs. Rapidly escalating costs of Medi-Cal led to irresistible pressures for reform, especially from the business community. The new Medi-Cal regulations provide for prospective contracts with hospitals for inpatient services, the transfer of “Medically Indigent Adults” to the responsibility of cou...

  12. Dofetilide: a class III anti-arrhythmic drug for the treatment of atrial fibrillation

    DEFF Research Database (Denmark)

    Torp-Pedersen, C; Brendorp, B; Køber, L

    2000-01-01

    , median time to relapse exceeded one year. Two large clinical studies that enrolled 3028 patients have been performed in high-risk patients with severe heart failure and large myocardial infarctions. The outcomes of these studies were neutral with respect to survival and demonstrated the safety....... Therefore, dosage must be carefully adjusted to the length of QTc interval, calculated creatinine clearance and the presence of heart failure or recent infarction. In addition, treatment must be initiated in hospital with three days of continuous telemetry. Dofetilide can be co-administered with digoxin...... and beta-blockers. Other anti-arrhythmic drugs, as well as drugs that interfere with the renal elimination or the metabolism of dofetilide, must be avoided. Dofetilide is an option when persistent atrial fibrillation is a clinical problem. In the setting of severe heart failure and large myocardial...

  13. 78 FR 14352 - Notice of Approved Class III Tribal Gaming Ordinances

    Science.gov (United States)

    2013-03-05

    ... 180. Pueblo of Isleta 181. Pueblo of Jemez 182. Pueblo of Laguna 183. Pueblo of Nambe 184. Pueblo of.... Yankton Sioux Tribe 283. Yavapai Apache Nation of the Camp Verde Indian Reservation 284....

  14. 25 CFR 291.4 - What must a proposal requesting Class III gaming procedures contain?

    Science.gov (United States)

    2010-04-01

    ... scheme for the State's oversight role, if any, in monitoring and enforcing compliance; and (j) Proposed... certification that the tribe's accounting procedures are maintained in accordance with American Institute of... accordance with Generally Accepted Accounting Principles and applicable NIGC regulations; (2) A...

  15. 75 FR 52294 - Effective Date of Requirement for Premarket Approval for Four Class III Preamendments Devices

    Science.gov (United States)

    2010-08-25

    ..., leading to the onset of cardiac arrhythmias. Electrical leakage can also cause electrical shock to the... response to the 515(i) order (74 FR 16214, April 9, 2009) and any additional information that FDA has... dates: Cardiovascular devices, 21 CFR part 870 (44 FR 13284, March 9, 1979; 45 FR 7904, February 5,...

  16. Evaluation of a class III biological safety cabinet for enclosure of an ultracentrifuge.

    Science.gov (United States)

    Chatigny, M A; Dunn, S; Ishimaru, K; Eagleson, J A; Prusiner, S B

    1979-11-01

    An evaluation of a special safety cabinet housing a high-speed centrifuge was made. The cabinet enclosed both the top access port and the drive and pumping machinery of the centrifuge. A titanium rotor was loaded with tubes containing a bacterial culture, weakened, and driven until rotor rupture occurred. There were several bent and broken components in the centrifuge, and bacteria leaked from the vacuum chamber. Although the forces were sufficient to displace the cabinet, none of the test bacteria were found outside the cabinet. PMID:543704

  17. Correction of transverse maxillary deficiency and anterior open bite in an adult Class III skeletal patient

    OpenAIRE

    Prerna Hoogan Teja; Samarjit Singh Teja; Nayak, Rabindra S; Abhijit Bagade; Manu Rashmi Sharma

    2016-01-01

    Transverse maxillary deficiency may be associated with sagittal or vertical problems of the maxilla or mandible. It may contribute to unilateral or bilateral posterior crossbite, anterior dental crowding, and unesthetic black buccal corridors on smiling. An adequate transverse dimension is important for stable and proper functional occlusion. Surgically, assisted rapid palatal expansion has been the treatment of choice to resolve posterior crossbite in skeletally mature patients. The followin...

  18. Bone graft on the labial symphysis for the skeletal Class III case

    OpenAIRE

    石亀, 勝; 清野, 幸男; 横田,光正; 水城, 春美; 三浦, 廣行; イシガメ, マサル; セイノ, ユキオ; ヨコタ, ミツマサ; ミズキ, ハルミ; ミウラ, ヒロユキ; Masaru, ISHIGAME; Yukio, SEINO; Mitsumasa, YOKOTA; Harumi, MIZUKI; Hiroyuki, Miura

    2003-01-01

    通常臨床歯科医学における骨移植は,その病理学的形態より3壁性骨欠損を有する歯周病患者に対して広く行われている。今回,下顎前歯部(下顎結合部)唇側面歯槽骨の開窓や限局性穿孔は存在するが,歯肉退縮を生じていない骨格型III級不正咬合患者へ顎矯正手術と同時に自家骨移植を付加的に行った。初診時のセファログラム所見より高く幅の狭い下顎結合部とこの薄い骨に直立している下顎前歯が確認された。また,術前矯正歯科治療中,下顎前歯はその捻転の解消と頬舌的な移動が行われた。手術時には下顎前歯部の開窓や限局性穿孔が確認された。下顎前歯部(下顎結合部)唇側面に自己海面骨を移植することによって歯槽骨の開窓や限局性穿孔は覆われた。結果的にセファログラム上での経過所見より,その後4年10か月間移植骨の残留が認められ,さらに臨床的に咬合が安定し通常後戻りしやすいとされる下顎前歯捻転の後戻りも認められず良好な結果を得たので報告した。...

  19. 78 FR 4094 - Effective Date of Requirement for Premarket Approval for Two Class III Preamendments Devices

    Science.gov (United States)

    2013-01-18

    ... long-term patient followup data were inadequate to demonstrate that special controls would provide... size of the metallic wear debris generated by other hip joint prostheses and the short-and long-term... length and rate of long-term patient followup data were inadequate to demonstrate that special...

  20. DOE/NNSA perspective safeguard by design: GEN III/III+ light water reactors and beyond

    Energy Technology Data Exchange (ETDEWEB)

    Pan, Paul Y [Los Alamos National Laboratory

    2010-12-10

    An overview of key issues relevant to safeguards by design (SBD) for GEN III/IV nuclear reactors is provided. Lessons learned from construction of typical GEN III+ water reactors with respect to SBD are highlighted. Details of SBD for safeguards guidance development for GEN III/III+ light water reactors are developed and reported. This paper also identifies technical challenges to extend SBD including proliferation resistance methodologies to other GEN III/III+ reactors (except HWRs) and GEN IV reactors because of their immaturity in designs.

  1. The SINTRAN III NODAL system

    International Nuclear Information System (INIS)

    NODAL is a high level programming language based on FOCAL and SNOBOL4, with some influence from BASIC. The language was developed to operate on the computer network controlling the SPS accelerator at CERN. NODAL is an interpretive language designed for interactive use. This is the most important aspect of the language, and is reflected in its structure. The interactive facilities make it possible to write, debug and modify programs much faster than with compiler based languages like FORTRAN and ALGOL. Apart from a few minor modifications, the basic part of the Oslo University NODAL system does not differ from the CERN version. However, the Oslo University implementation has been expanded with new functions which enable the user to execute many of the SINTRAN III monitor calls from the NODAL level. In particular the most important RT monitor calls have been implemented in this way, a property which renders possible the use of NODAL as a RT program administrator. (JIW)

  2. Nitrato-complexes of Y(III), La(III), Ce(III), Pr(III), Nd(III), Sm(III), Gd(III), Tb(III), Dy(III) and Ho(III) with 2-(2'-pyridyl) benzimidazole

    International Nuclear Information System (INIS)

    The nitrato-complexes, [Y(PyBzH)2(NO3)2]NO3.H2O and Nd, Sm, Gd, Tb, Dy, Ho ; n=1-3, m=0-0.5 ; PyBzh=2-(2 -pyridyl)benzimidazole] are formed on interaction of the ligand with metal nitrates in ethanol. The electrical conductance values (116-129 ohm-1cm2mol-1) suggest 1:1 electrolyte-nature of the complexes. Magnetic moment values of Ce(2.53 B.M.), Pr(3.62 B.M.), Nd(3.52 B.M.), Sm(1.70 B.M.), Gd(8.06 B.M.), Tb(9.44 B.M.), Dy(10.56 B.M.) and Ho(10.51 B.M.) in the complexes confirm the terpositive state of the metals. Infrared evidences are obtained for the existance of both coordinated (C2v) and uncoordinated (D3h) nitrate groups. Electronic absorption spectra of Pr(III)-, Nd(III)-, Sm(III)-, Tb(III)-, Dy(III)- and Ho(III)-complexes have been analysed in the light of LSJ terms. (author)

  3. Mid-Infrared Observations of Class I/Flat-Spectrum Systems in Six Nearby Molecular Clouds

    CERN Document Server

    Haisch, Karl E; Ressler, M E; Greene, T P; Jr., Karl E. Haisch; Barsony, Mary; Ressler, Michael E.; Greene, Thomas P.

    2006-01-01

    We have obtained new mid-infrared observations of 65 Class I/Flat-Spectrum (F.S.) objects in the Perseus, Taurus, Chamaeleon I/II, Rho Ophiuchi, and Serpens dark clouds. We detected 45/48 (94%) of the single sources, 16/16 (100%) of the primary components, and 12/16 (75%) of the secondary/triple components of the binary/multiple objects surveyed. The composite spectral energy distributions (SEDs) for all of our sample sources are either Class I or F.S., and, in 15/16 multiple systems, at least one of the individual components displays a Class I or F.S. spectral index. However, the occurrence of mixed pairings, such as F.S. with Class I, F.S. with Class II, and, in one case, F.S. with Class III, is surprisingly frequent. Such behaviour is not consistent with that of multiple systems among T Tauri stars (TTS), where the companion of a classical TTS also tends to be a classical TTS, although other mixed pairings have been previously observed among Class II objects. Based on an analysis of the spectral indices of...

  4. Class in Metropolitan India: The Rise of the Middle Classes

    OpenAIRE

    Mooij, Jos; Lama-Rewal, S.T.

    2009-01-01

    textabstractIt is almost a cliché to say that India’s appearance and image (internationally as well as self-image) have changed dramatically in the last fifteen years. Instead of being associated with rural poverty, India is now associated with high rates of economic growth, a booming Information Technology (IT) sector and, particularly, an increasingly expanding middle class that consumes and behaves like elites and middle classes elsewhere in the world. Considering that cities concentrate m...

  5. Characterization of ribonuclease III from Brucella.

    Science.gov (United States)

    Wu, Chang-Xian; Xu, Xian-Jin; Zheng, Ke; Liu, Fang; Yang, Xu-Dong; Chen, Chuang-Fu; Chen, Huan-Chun; Liu, Zheng-Fei

    2016-04-01

    Bacterial ribonuclease III (RNase III) is a highly conserved endonuclease, which plays pivotal roles in RNA maturation and decay pathways by cleaving double-stranded structure of RNAs. Here we cloned rncS gene from the genomic DNA of Brucella melitensis, and analyzed the cleavage properties of RNase III from Brucella. We identified Brucella-encoding small RNA (sRNA) by high-throughput sequencing and northern blot, and found that sRNA of Brucella and Homo miRNA precursor (pre-miRNA) can be bound and cleaved by B.melitensis ribonuclease III (Bm-RNase III). Cleavage activity of Bm-RNase III is bivalent metal cations- and alkaline buffer-dependent. We constructed several point mutations in Bm-RNase III, whose cleavage activity indicated that the 133th Glutamic acid residue was required for catalytic activity. Western blot revealed that Bm-RNase III was differently expressed in Brucella virulence strain 027 and vaccine strain M5-90. Collectively, our data suggest that Brucella RNase III can efficiently bind and cleave stem-loop structure of small RNA, and might participate in regulation of virulence in Brucella.

  6. New Ramsey Classes from Old

    CERN Document Server

    Bodirsky, Manuel

    2012-01-01

    Let C_1 and C_2 be strong amalgamation classes of finite structures, with disjoint finite signatures sigma and tau. Then C_1 wedge C_2 denotes the class of all finite (sigma cup tau)-structures whose sigma-reduct is from C_1 and whose tau-reduct is from C_2. We prove that when C_1 and C_2 are Ramsey, then C_1 wedge C_2 is also Ramsey. We also discuss variations of this statement, and give several examples of new Ramsey classes derived from those general results.

  7. Lipschitz classes on local fields

    Institute of Scientific and Technical Information of China (English)

    Wei-yi SU; Guo-xiang CHEN

    2007-01-01

    The Lipschitz class Lipα on a local field K is defined in this note, and the equivalent relationship between the Lipschitz class Lipα and the Holder type space Cα (K) is proved. Then, those important characteristics on the Euclidean space Rn and the local field K are compared, so that one may interpret the essential differences between the analyses on Rn and K. Finally, the Cantor type fractal function (V)(x) is showed in the Lipschitz class Lip (m, K), m < ln2/ln3.

  8. Management of Classes with Breaches of Discipline

    Institute of Scientific and Technical Information of China (English)

    陈海军

    2009-01-01

    As an only child is pampered and spoiled by parents, the contemporary student easily breaches class discipline. Class management appears more concerned than ever because breaches of class discipline have great impact on teaching. The author clarifies the necessity to study the management of classes with breaches of class discipline, numerates the phenomena of breaches of class discipline, precisely analyzes the causes from teachers and students and especially submits several measures to effectively prevent breaches of class discipline.

  9. Generalized analytical design equations for variable slope class-e power amplifiers

    NARCIS (Netherlands)

    Acar, Mustafa; Annema, Anne Johan; Nauta, Bram

    2006-01-01

    The Class-E power amplifier is widely used because of its high efficiency, resulting from switching at zero voltage and zero slope of the switch voltage. In this paper, we extend our general analytical solutions for the Class-E power amplifier to the ideal single-ended Variable Slope Class-E (Class-

  10. Heterotrimetallic coordination polymers: {Cu(II)Ln(III)Fe(III)} chains and {Ni(II)Ln(III)Fe(III)} layers: synthesis, crystal structures, and magnetic properties.

    Science.gov (United States)

    Alexandru, Maria-Gabriela; Visinescu, Diana; Andruh, Marius; Marino, Nadia; Armentano, Donatella; Cano, Joan; Lloret, Francesc; Julve, Miguel

    2015-03-27

    The use of the [Fe(III) (AA)(CN)4](-) complex anion as metalloligand towards the preformed [Cu(II) (valpn)Ln(III)](3+) or [Ni(II) (valpn)Ln(III) ](3+) heterometallic complex cations (AA=2,2'-bipyridine (bipy) and 1,10-phenathroline (phen); H2 valpn=1,3-propanediyl-bis(2-iminomethylene-6-methoxyphenol)) allowed the preparation of two families of heterotrimetallic complexes: three isostructural 1D coordination polymers of general formula {[Cu(II) (valpn)Ln(III) (H2O)3 (μ-NC)2 Fe(III) (phen)(CN)2 {(μ-NC)Fe(III) (phen)(CN)3}]NO3 ⋅7 H2O}n (Ln=Gd (1), Tb (2), and Dy (3)) and the trinuclear complex [Cu(II) (valpn)La(III) (OH2 )3 (O2 NO)(μ-NC)Fe(III) (phen)(CN)3 ]⋅NO3 ⋅H2O⋅CH3 CN (4) were obtained with the [Cu(II) (valpn)Ln(III)](3+) assembling unit, whereas three isostructural heterotrimetallic 2D networks, {[Ni(II) (valpn)Ln(III) (ONO2 )2 (H2 O)(μ-NC)3 Fe(III) (bipy)(CN)]⋅2 H2 O⋅2 CH3 CN}n (Ln=Gd (5), Tb (6), and Dy (7)) resulted with the related [Ni(II) (valpn)Ln(III) ](3+) precursor. The crystal structure of compound 4 consists of discrete heterotrimetallic complex cations, [Cu(II) (valpn)La(III) (OH2)3 (O2 NO)(μ-NC)Fe(III) (phen)(CN)3 ](+), nitrate counterions, and non-coordinate water and acetonitrile molecules. The heteroleptic {Fe(III) (bipy)(CN)4} moiety in 5-7 acts as a tris-monodentate ligand towards three {Ni(II) (valpn)Ln(III)} binuclear nodes leading to heterotrimetallic 2D networks. The ferromagnetic interaction through the diphenoxo bridge in the Cu(II)-Ln(III) (1-3) and Ni(II)-Ln(III) (5-7) units, as well as through the single cyanide bridge between the Fe(III) and either Ni(II) (5-7) or Cu(II) (4) account for the overall ferromagnetic behavior observed in 1-7. DFT-type calculations were performed to substantiate the magnetic interactions in 1, 4, and 5. Interestingly, compound 6 exhibits slow relaxation of the magnetization with maxima of the out-of-phase ac signals below 4.0 K in the lack of a dc field, the values of the pre

  11. Separation of americium(III) from lanthanides(III) by nanofiltration-complexation in aqueous medium

    International Nuclear Information System (INIS)

    The separation of Am(III) from a mixture of lanthanides(III) was performed in aqueous medium by nanofiltration combined with a complexation step using a DTPA derivative as selective complexing agent. (author)

  12. Class attendance and university performance

    OpenAIRE

    Hoffmann, Anna-Lena; Lerche, Katharina

    2016-01-01

    Using survey data collected at Göttingen University, Germany, this paper evaluates the effect of attending the lecture and/or tutorial on the grade achieved in two basic courses in business administration and economics. The analysis shows that going to class has no significant impact on student performance in most specifications. Although the identification of a causal effect may not be possible with the data at hand, the results suggest that, in the given framework, attending class and study...

  13. Whole Class Laboratories: More Examples

    Science.gov (United States)

    Kouh, Minjoon

    2016-03-01

    Typically, introductory physics courses are taught with a combination of lectures and laboratories in which students have opportunities to discover the natural laws through hands-on activities in small groups. This article reports the use of Google Drive, a free online document-sharing tool, in physics laboratories for pooling experimental data from the whole class. This pedagogical method was reported earlier, and the present article offers a few more examples of such "whole class" laboratories.

  14. Less than a Class Set

    Science.gov (United States)

    Bennett, Kristin Redington

    2012-01-01

    The iPad holds amazing potential for classroom use. Just a few--or even only one--is enough to get results. Having a class set promotes traditional, whole-class instruction, but fewer iPads facilitate individualized and tailored instruction. In this article, the author discusses the potential of the iPad and suggests ways to put the iPad to use in…

  15. Internet service classes under competition

    OpenAIRE

    Gibbens, R.; R. Mason; Steinberg, Richard

    2000-01-01

    This paper analyzes competition between two Internet service providers (ISPs), either or both of which may choose to offer multiple service classes. In the model analyzed, a social planner who maximizes the total benefit from network usage and a profit maximizing monopolist will both form multiple service classes; but two networks competing to maximize profits will not. The reason is that a competition effect always outweighs a segmentation effect. Networks wish to offer multiple service clas...

  16. Mechanisms of Sb(III) Photooxidation by the Excitation of Organic Fe(III) Complexes.

    Science.gov (United States)

    Kong, Linghao; He, Mengchang

    2016-07-01

    Organic Fe(III) complexes are widely distributed in the aqueous environment, which can efficiently generate free radicals under light illumination, playing a significant role in heavy metal speciation. However, the potential importance of the photooxidation of Sb(III) by organic Fe(III) complexes remains unclear. Therefore, the photooxidation mechanisms of Sb(III) were comprehensively investigated in Fe(III)-oxalate, Fe(III)-citrate and Fe(III)-fulvic acid (FA) solutions by kinetic measurements and modeling. Rapid photooxidation of Sb(III) was observed in an Fe(III)-oxalate solution over the pH range of 3 to 7. The addition of tert-butyl alcohol (TBA) as an ·OH scavenger quenched the Sb(III) oxidation, suggesting that ·OH is an important oxidant for Sb(III). However, the incomplete quenching of Sb(III) oxidation indicated the existence of other oxidants, presumably an Fe(IV) species in irradiated Fe(III)-oxalate solution. In acidic solutions, ·OH may be formed by the reaction of Fe(II)(C2O4) with H2O2, but a hypothetical Fe(IV) species may be generated by the reaction of Fe(II)(C2O4)2(2-) with H2O2 at higher pH. Kinetic modeling provides a quantitative explanation of the results. Evidence for the existence of ·OH and hypothetical Fe(IV) was also observed in an irradiated Fe(III)-citrate and Fe(III)-FA system. This study demonstrated an important pathway of Sb(III) oxidation in surface waters. PMID:27267512

  17. Theoretical Prediction of Topological Insulators in Thallium-based III-V-VI$_2$ Ternary Chalcogenides

    OpenAIRE

    Yan, Binghai; Liu, Chao-Xing; Zhang, Hai-Jun; Yam, Chi-Yung; Qi, Xiao-Liang; Frauenheim, Thomas; Zhang, Shou-Cheng

    2010-01-01

    We predict a new class of three dimensional topological insulators in thallium-based III-V-VI$_2$ ternary chalcogenides, including TlBiQ$_2$ and TlSbQ$_2$ (Q = Te, Se and S). These topological insulators have robust and simple surface states consisting of a single Dirac cone at the $\\Gamma$ point. The mechanism for topological insulating behavior is elucidated using both first principle calculations and effective field theory models. Remarkably, one topological insulator in this class, TlBiTe...

  18. A New Complete Class Complexity Metric

    OpenAIRE

    Singh, Vinay; Bhattacherjee, Vandana

    2014-01-01

    Software complexity metrics is essential for minimizing the cost of software maintenance. Package level and System level complexity cannot be measured without class level complexity. This research addresses the class complexity metrics. This paper studies the existing class complexity metrics and proposes a new class complexity metric CCC (Complete class complexity metric). The CCC metric is then analytically evaluated by Weyuker's property.

  19. Synthesis and in vitro microbial evaluation of La(III), Ce(III), Sm(III) and Y(III) metal complexes of vitamin B6 drug

    Science.gov (United States)

    Refat, Moamen S.; Al-Azab, Fathi M.; Al-Maydama, Hussein M. A.; Amin, Ragab R.; Jamil, Yasmin M. S.

    2014-06-01

    Metal complexes of pyridoxine mono hydrochloride (vitamin B6) are prepared using La(III), Ce(III), Sm(III) and Y(III). The resulting complexes are investigated. Some physical properties, conductivity, analytical data and the composition of the four pyridoxine complexes are discussed. The elemental analysis shows that the formed complexes of La(III), Ce(III), Sm(III) and Y(III) with pyridoxine are of 1:2 (metal:PN) molar ratio. All the synthesized complexes are brown in color and possess high melting points. These complexes are partially soluble in hot methanol, dimethylsulfoxide and dimethylformamide and insoluble in water and some other organic solvents. Elemental analysis data, spectroscopic (IR, UV-vis. and florescence), effective magnetic moment in Bohr magnetons and the proton NMR suggest the structures. However, definite particle size is determined by invoking the X-ray powder diffraction and scanning electron microscopy data. The results obtained suggested that pyridoxine reacted with metal ions as a bidentate ligand through its phenolate oxygen and the oxygen of the adjacent group at the 4‧-position. The molar conductance measurements proved that the pyridoxine complexes are electrolytic in nature. The kinetic and thermodynamic parameters such as: Ea, ΔH*, ΔS* and ΔG* were estimated from the DTG curves. The antibacterial evaluation of the pyridoxine and their complexes were also performed against some gram positive, negative bacteria as well as fungi.

  20. Synthesis, spectroscopic and antimicrobial studies of La(III), Ce(III), Sm(III) and Y(III) Metformin HCl chelates

    Science.gov (United States)

    Refat, Moamen S.; Al-Azab, Fathi M.; Al-Maydama, Hussein M. A.; Amin, Ragab R.; Jamil, Yasmin M. S.; Kobeasy, Mohamed I.

    2015-05-01

    Metal complexes of Metformin hydrochloride were prepared using La(III), Ce(III), Sm(III) and Y(III). The resulting complexes were discussed and synthesized to serve as potential insulin-mimetic. Some physical properties and analytical data of the four complexes were checked. The elemental analysis shows that La(III), Ce(III) Sm(III) and Y(III) formed complexes with Metformin in 1:3 (metal:MF) molar ratio. All the synthesized complexes are white and possess high melting points. These complexes are soluble in dimethylsulfoxide and dimethylformamide, partially soluble in hot methanol and insoluble in water and some other organic solvents. From the spectroscopic (infrared, UV-vis and florescence), effective magnetic moment and elemental analyses data, the formula structures are suggested. The results obtained suggested that Metformin reacted with metal ions as a bidentate ligand through its two imino groups. The molar conductance measurements proved that the Metformin complexes are slightly electrolytic in nature. The kinetic thermodynamic parameters such as: E∗, ΔH∗, ΔS∗ and ΔG∗ were estimated from the DTG curves. The antibacterial evaluations of the Metformin and their complexes were also performed against some gram positive, negative bacteria as well as fungi.

  1. Iron(III) spin crossover compounds

    NARCIS (Netherlands)

    van Koningsbruggen, PJ; Maeda, Y; Oshio, H

    2004-01-01

    In this chapter, selected results obtained so far on Fe(III) spin crossover compounds are summarized and discussed. Fe(III) spin transition materials of ligands containing chalcogen donor atoms are considered with emphasis on those of N,N-disubstituted-dithiocarbamates, N,N-disubstituted-XY-carbamat

  2. PENGGUNAAN FACE-MASK & EKSPANSI PALATAL PADA PERAWATAN MALOKLUSI KLAS III (Studi Pustaka

    Directory of Open Access Journals (Sweden)

    Krisnawati Krisnawati

    2015-08-01

    Full Text Available Class III skeletal anomaly is one of the most difficult malocclusions to correct in orthodontics. Orthodontist usually involved chincup appliances to restrain mandibular growth, camouflage techniques to advances maxillary incisors and retract mandibular incisors or waiting untul growth ceased to pursue orthognathic surgery. Many studies found that most of Class III malocclusions were characterized by maxillary retrognathism. In the late 1960s, the Delaire mask was popularized to protract the maxilla. The development of maxillary protraction with facemask and palatal expansion have provided a predictable and effective approach to managing treatment that was once considered difficult. Although no significant difference was found between early or late treatment group, the effect of improvement in facial aesthetics on psychosocial development resulted in a significant advantage for early treatment. However, the effects of face mask therapy should be evaluated over the long term in order to determine the relaps tendency.

  3. Classes subalternas, lutas de classe e hegemonia: uma abordagem gramsciana Subaltern classes, class struggles and hegemony: a gramscian approach

    Directory of Open Access Journals (Sweden)

    Ivete Simionatto

    2009-06-01

    Full Text Available O artigo procura resgatar, no pensamento de Antonio Gramsci, a concepção de classes subalternas e a sua relação com outras categorias, especialmente, o Estado, a sociedade civil e a hegemonia, como suportes da luta de classes na realidade contemporânea. Aborda, ainda, as relações entre classes subalternas, senso comum e ideologia, bem como as formas de superação tematizadas por Gramsci, através da cultura e da filosofia da práxis. Nesse sentido, num movimento de totalidade, busca recuperar a discussão das classes subalternas, a partir da original formulação gramsciana no âmbito do marxismo, mediante a interação dialética entre estrutura e superestrutura, economia e política. Além do resgate conceitual, apontam-se alguns elementos como subsídios à discussão das formas de subalternidade presentes na realidade contemporânea e as possibilidades de fortalecimento das lutas de tais camadas de classe, sobretudo em momentos de forte desmobilização da participação popular.This article sought to revive the concept of subaltern classes and their relation with other categories, particularly the State, civil society and hegemony in the thinking of Antonio Gramsci, as a support for contemporary class struggles. It also analyzes the relations between subaltern classes, common sense and ideology, as well as the forms of "overcoming" conceptualized by Gramsci, through the culture and philosophy of praxis. The paper revives the discussion of the subaltern classes, based on the original Gramscian formulation in the realm of Marxism, through the dialectic interaction between structure and superstructure, economy and politics. In addition to the conceptual revival, it indicates some elements that can support the discussion of the forms of subalternity found in contemporary reality and the possibilities for strengthening the struggles of these class layers, above all in moments of strong demobilization of popular participation.

  4. Investigation of III-V semiconductor heterostructures for post-Si-CMOS applications

    Science.gov (United States)

    Bhatnagar, Kunal

    Silicon complementary metal-oxide-semiconductor (CMOS) technology in the past few decades has been driven by aggressive device scaling to increase performance, reduce cost and lower power consumption. However, as devices are scaled below the 100 nm region, performance gain has become increasingly difficult to obtain by traditional scaling. As we move towards advanced technology nodes, materials innovation and physical architecture are becoming the primary enabler for performance enhancement in CMOS technology rather than scaling. One class of materials that can potentially result in improved electrical performance are III-V semiconductors, which are ideal candidates for replacing the channel in Si CMOS owing to their high electron mobilities and capabilities for band-engineering. This work is aimed towards the growth and characterization of III-V semiconductor heterostructures and their application in post-Si-CMOS devices. The two main components of this study include the integration of III-V compound semiconductors on silicon for tunnel-junction Esaki diodes, and the investigation of carrier transport properties in low-power III-V n-channel FETs under uniaxial strain for advanced III-V CMOS solutions. The integration of III-V compound semiconductors with Si can combine the cost advantage and maturity of the Si technology with the superior performance of III-V materials. We have demonstrated high quality epitaxial growth of GaAs and GaSb on Si (001) wafers through the use of various buffer layers including AlSb and crystalline SrTiO3. These GaSb/Si virtual substrates were used for the fabrication and characterization of InAs/GaSb broken-gap Esaki-tunnel diodes as a possible solution for heterojunction Tunnel-FETs. In addition, the carrier transport properties of InAs channels were evaluated under uniaxial strain for the potential use of strain solutions in III-V CMOS.

  5. A note on classification of proper homothetic vector fields in Kantowski-Sachs and Bianchi type III Lorentzian manifolds

    CERN Document Server

    Shabbir, Ghulam

    2011-01-01

    A complete study of Kantowski-Sachs and Bianchi type III space-times according to their proper homothetic vector fields is given by using direct integration technique. Using the above mentioned technique we have shown that very special classes of the above space-times admit proper homothetic vector fields. The dimension of homothetic vector fields is five.

  6. Enhanced optical nonlinearities in the near-infrared using III-nitride heterostructures coupled to metamaterials

    Energy Technology Data Exchange (ETDEWEB)

    Wolf, Omri, E-mail: owolf@sandia.gov, E-mail: ibrener@sandia.gov; Ma, Xuedan; Brener, Igal, E-mail: owolf@sandia.gov, E-mail: ibrener@sandia.gov [Center for Integrated Nanotechnologies, Sandia National Laboratories, P.O. Box 5800, Albuquerque, New Mexico 87185 (United States); Sandia National Laboratories, P.O. Box 5800, Albuquerque, New Mexico 87185 (United States); Allerman, Andrew A.; Wendt, Joel R.; Shaner, Eric A. [Sandia National Laboratories, P.O. Box 5800, Albuquerque, New Mexico 87185 (United States); Song, Alex Y. [Electrical Engineering Department, Princeton University, EQuad, Olden St, Princeton, New Jersy 08540 (United States)

    2015-10-12

    We use planar metamaterial resonators to enhance by more than two orders of magnitude the near infrared second harmonic generation obtained from intersubband transitions in III-Nitride heterostructures. The improvement arises from two factors: employing an asymmetric double quantum well design and aligning the resonators' cross-polarized resonances with the intersubband transition energies. The resulting nonlinear metamaterial operates at wavelengths where single photon detection is available, and represents a different class of sources for quantum photonics related phenomena.

  7. High Power Wideband Class-E Power Amplifier

    OpenAIRE

    Ortega González, Francisco Javier

    2010-01-01

    This letter shows a high-power, high-efficiency, wideband Class-E RF power amplifier designed upon the load admittance synthesis concept and built using an uncomplicated low-loss load network with a low loss wideband admittance transformer as the main component. It uses a power Silicon LDMOS transistor to provide up to 145 W at 28 V peak power, up to 86% drain efficiency over 35% fractional bandwidth (from 85 to 120 MHz) and 15.6 dB gain at peak power without any adjustments. These are clear ...

  8. Classe social, Estado e ideologia Social class, State and ideology

    Directory of Open Access Journals (Sweden)

    Leopoldo Waizbort

    1998-05-01

    Full Text Available O texto reproduz uma aula para concurso junto ao Departamento de Sociologia da FFLCH-USP na qual tentei articular o tríptico classe social, Estado e ideologia, tendo em mente a situação contemporânea empírica e teórica dos três conceitos.This text reproduces a lecture given in the scope of an examination at the Sociology Department of the FFLCH-USP. For the presentation I have tried to articulate the three concepts "social class", "State" and "ideology", by taking into consideration their actual empirical and theoretical situation.

  9. Lanthanide(III and Yttrium(III Complexes of Benzimidazole-2-Acetic Acid: Synthesis, Characterisation and Effect of La(III Complex on Germination of Wheat

    Directory of Open Access Journals (Sweden)

    2006-01-01

    Full Text Available The synthesis and characterisation of lanthanide(III and yttrium(III nitrate complexes of benzimidazole-2-acetic acid (HBIA are reported. The complexes have been characterised by elemental analysis, molar conductance, magnetic studies, IR, 1 H NMR, UV-visible, EPR, and TG/DTA studies. They have the stoichiometry [ Ln 3 ( BIA 2 ( NO 3 7 ( H 2 O 4 ]⋅3 H 2 O where Ln=La(III, Pr(III, Nd(II, Sm(III, Eu(III, Gd(III, Tb(III, Dy(III, and Y(III. The effect of La(III complex on germination, coleoptile, and root length of two local varieties of wheat DWR-195 and GW-349 for different treatment periods has been investigated. The complex was found to exhibit enhanced activity, compared to HBIA or metal salt alone at lower treatment periods.

  10. Association of Eu(III) and Cm(III) with Bacillus subtilis and Halobacterium salinarum

    Energy Technology Data Exchange (ETDEWEB)

    Ozaki, Takuo; Kimura, Takaumi; Ohnuki, Toshihiko; Yoshida, Zenko [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Gillow, Jeffrey B.; Francis, Arokiasamy J. [Brookhaven National Laboratory, Upton, NY (United States)

    2002-11-01

    Adsorption behavior of Eu(III) and Cm(III) by Bacillus subtilis and Halobacterium salinarum was investigated. Both microorganisms showed almost identical pH dependence on the distribution ratio (K{sub d}) of the metals examined, i.e., K{sub d} of Eu(III) and Cm(III) increased with an increase of pH. The coordination state of Eu(III) adsorbed on the microorganisms was studied by time-resolved laser-induced fluorescence spectroscopy (TRLFS). The coordination states of Eu(III) adsorbed on the B. subtilis and H. salinarum was of different characteristics. H. salinarum exhibited more outer-spherical interaction with Eu(III) than B. subtilis. (author)

  11. Rapid photooxidation of Sb(III) in the presence of different Fe(III) species

    Science.gov (United States)

    Kong, Linghao; He, Mengchang; Hu, Xingyun

    2016-05-01

    The toxicity and mobility of antimony (Sb) are strongly influenced by the redox processes associated with Sb. Dissolved iron (Fe) is widely distributed in the environment as different species and plays a significant role in Sb speciation. However, the mechanisms of Sb(III) oxidation in the presence of Fe have remained unclear because of the complexity of Fe and Sb speciation. In this study, the mechanisms of Sb(III) photooxidation in the presence of different Fe species were investigated systematically. The photooxidation of Sb(III) occurred over a wide pH range, from 1 to 10. Oxygen was not a predominant or crucial factor in the Sb(III) oxidation process. The mechanism of Sb(III) photooxidation varied depending on the Fe(III) species. In acidic solution (pH 1-3), dichloro radicals (radCl2-) and hydroxyl radicals (radOH) generated by the photocatalysis of FeCl2+ and FeOH2+ were the main oxidants for Sb(III) oxidation. Fe(III) gradually transformed into the colloid ferric hydroxide (CFH) and ferrihydrite in circumneutral and alkaline solutions (pH 4-10). Photooxidation of Sb(III) occurred through electron transfer from Sb(III) to Fe(III) along with the reduction of Fe(III) to Fe(II) through a ligand-to-metal charge-transfer (LMCT) process. The photocatalysis of different Fe(III) species may play an important role in the geochemical cycle of Sb(III) in surface soil and aquatic environments.

  12. Towards a Class Struggle Anthropology

    Directory of Open Access Journals (Sweden)

    Charles R. Menzies

    2007-05-01

    Full Text Available Dancing between review and argument this paper lays out a foundation for a class-struggle anthropology -that is, an anthropological practice that can be linked to the ultimate goal of achieving a classless society. To this end we will review those anthropologists who have gone before us, pulling out those works of theirs that we see as critical in (rebuilding a class-struggle anthropology. As part of this process we discuss the relationship between what has stood as Marxist anthropology in North America, the idea of socialism, the political development of the world working class during nine decades since the October Revolution, and the challenges of intellectual continuity in the face of differing generational experiences of Marxist anthropologists. Ultimately we argue that a progressive anthropology necessarily involves political activism in our work, communities, and schools.

  13. Universality class in conformal inflation

    Energy Technology Data Exchange (ETDEWEB)

    Kallosh, Renata; Linde, Andrei, E-mail: kallosh@stanford.edu, E-mail: alinde@stanford.edu [Department of Physics and SITP, Stanford University, Stanford, California 94305 (United States)

    2013-07-01

    We develop a new class of chaotic inflation models with spontaneously broken conformal invariance. Observational consequences of a broad class of such models are stable with respect to strong deformations of the scalar potential. This universality is a critical phenomenon near the point of enhanced symmetry, SO(1,1), in case of conformal inflation. It appears because of the exponential stretching of the moduli space and the resulting exponential flattening of scalar potentials upon switching from the Jordan frame to the Einstein frame in this class of models. This result resembles stretching and flattening of inhomogeneities during inflationary expansion. It has a simple interpretation in terms of velocity versus rapidity near the Kähler cone in the moduli space, similar to the light cone of special theory of relativity. This effect makes inflation possible even in the models with very steep potentials. We describe conformal and superconformal versions of this cosmological attractor mechanism.

  14. Thermodynamic data for predicting concentrations of Pu(III), Am(III), and Cm(III) in geologic environments

    Energy Technology Data Exchange (ETDEWEB)

    Rai, Dhanpat; Rao, Linfeng; Weger, H.T.; Felmy, A.R. [Pacific Northwest National Laboratory, WA (United States); Choppin, G.R. [Florida State University, Florida (United States); Yui, Mikazu [Japan Nuclear Cycle Development Inst., Tokai Works, Tokai, Ibaraki (Japan)

    1999-01-01

    This report provides thermodynamic data for predicting concentrations of Pu(III), Am(III), and Cm(III) in geologic environments, and contributes to an integration of the JNC chemical thermodynamic database, JNC-TDB (previously PNC-TDB), for the performance analysis of geological isolation system for high-level radioactive wastes. Thermodynamic data for the formation of complexes or compounds with hydroxide, chloride, fluoride, carbonate, nitrate, sulfate and phosphate are discussed in this report. Where data for specific actinide(III) species are lacking, the data were selected based on chemical analogy to other trivalent actinides. In this study, the Pitzer ion-interaction model is mainly used to extrapolate thermodynamic constants to zero ionic strength at 25degC. (author)

  15. Comprehensive evaluation of functional and anatomical disorders of the patients with distal occlusion and accompanying obstructive sleep apnea syndrome

    Science.gov (United States)

    Nabiev, F. H.; Dobrodeev, A. S.; Libin, P. V.; Kotov, I. I.; Ovsyannikov, A. G.

    2015-11-01

    The paper defines the therapeutic and rehabilitation approach to the patients with Angle's classification Class II dento-facial anomalies, accompanied by obstructive sleep apnea (OSA). The proposed comprehensive approach to the diagnostics and treatment of patients with posterior occlusion, accompanied by OSA, allows for objective evaluation of intensity of a dento-facial anomaly and accompanying respiratory disorders in the nasal and oral pharynx, which allows for the pathophysiological mechanisms of OSA to be identified, and an optimal plan for surgical procedures to be developed. The proposed comprehensive approach to the diagnostics and treatment of patients with Angle's classification Class II dento-facial anomalies provides high functional and aesthetic results.

  16. Active Learning in Large Classes

    DEFF Research Database (Denmark)

    Gørtz, Inge Li

    2011-01-01

    teaching large classes (more than 50 students), and describe how we successfully have in a second semester course in the Bachelor of Engineering (BEng) and Bachelor of Science Engineering (BSc Eng) program at the Technical University of Denmark (DTU). Approximately 200 students is attending...... the lectures in the course. The main idea is to use inductive, case-based learning, with many small exercises/ discussions during the lectures. We describe a framework for the lectures, that most lectures in the class were based on. The framework contains the conceive, design, and implement stage from the CDIO...

  17. A library of function classes

    International Nuclear Information System (INIS)

    We have written a library of function classes in C++, which is distributed as part of the CLHEP foundation class libraries for High Energy Physics. The main goals of the library are to provide objects having all the mathematical behavior of functions, and to provide a mechanism for parameterizing these functions. Our functions support all the normal function operations such as addition, subtraction, multiplication, division, composition, et. cetera. The library allows programmers to compose complicated one-or multi-dimensional functions with great economy and natural semantics

  18. On uniqueness of characteristic classes

    DEFF Research Database (Denmark)

    Feliu, Elisenda

    2011-01-01

    We give an axiomatic characterization of maps from algebraic K-theory. The results apply to a large class of maps from algebraic K-theory to any suitable cohomology theory or to algebraic K-theory. In particular, we obtain comparison theorems for the Chern character and Chern classes and for the...... Adams operations and ¿-operations on higher algebraic K-theory. We show that the Adams operations and ¿-operations defined by Grayson agree with the ones defined by Gillet and Soulé....

  19. Enzymatic Browning: a practical class

    Directory of Open Access Journals (Sweden)

    Maria Teresa Pedrosa Silva Clerici

    2014-10-01

    Full Text Available This paper presents a practical class about the enzymes polyphenol oxidases, which have been shown to be responsible for the enzymatic browning of fruits and vegetables. Vegetables samples were submitted to enzymatic inactivation process with chemical reagents, as well as by bleaching methods of applying heat by conventional oven and microwave oven. Process efficiency was assessed qualitatively by both observing the guaiacol peroxidase activity and after the storage period under refrigeration or freezing. The practical results obtained in this class allow exploring multidisciplinary knowledge in food science, with practical applications in everyday life.

  20. III-V semiconductor materials and devices

    CERN Document Server

    Malik, R J

    1989-01-01

    The main emphasis of this volume is on III-V semiconductor epitaxial and bulk crystal growth techniques. Chapters are also included on material characterization and ion implantation. In order to put these growth techniques into perspective a thorough review of the physics and technology of III-V devices is presented. This is the first book of its kind to discuss the theory of the various crystal growth techniques in relation to their advantages and limitations for use in III-V semiconductor devices.

  1. Determination of midsagittal plane for evaluation of facial asymmetry using three-dimensional computed tomography

    International Nuclear Information System (INIS)

    The aim of the present study was to investigate the disagreement of cephalometric analysis depending on the reference determination of midsagittal plane on three-dimensional computed tomography. A total of 102 young women with class III dentofacial deformity were evaluated using three-dimensional computed tomography. The cranial and facial midsagittal planes were defined and the amounts of jaw deviation were calculated. The amounts of jaw deviation were compared with paired t-test (2-tailed) and Bland-Altman plot was drawn. The landmark tracing were reproducible (r≥.978). The jaws relative to the cranial midsagittal plane were 10-17 times more significantly deviated than to the facial midsagittal plane (P<.001). Bland-Altman plot demonstrated that the differences between the amounts of jaw deviation from two midsagittal planes were not normally distributed versus the average of the amounts of jaw deviation from two midsagittal planes. The cephalometric analyses of facial asymmetry were significantly inconsistent depending on the reference determination of midsagittal plane. The reference for midsagittal plane should be carefully determined in three-dimensional cephalometric analysis of facial asymmetry of patients with class III dentofacial deformity.

  2. European Energy Law. Report III

    Energy Technology Data Exchange (ETDEWEB)

    Hammer, U.; Roggenkamp, M.M. (eds.)

    2006-07-01

    The European Energy Law Report III presents an overview of the most important legal developments in the field of EU and national energy law as discussed at the 2005 European Energy Law Seminar. It examines the Commission's recent progress report on the implementation of the 2003 energy directives, its sector inquiry regarding competition conditions in the energy markets, and its recent policy on vertical and conglomerate mergers in the light of its ongoing concern as to the increased levels of concentration in Europe's energy markets. The investigation of the Bundeskartellamt in Germany concerns the role of long-term downstream gas supply agreements in a liberalised market. Regulators are increasingly confronted with the need to secure the quality of electricity supply in a competitive market. After an analysis of how electricity distribution companies can be regulated with respect to quality of supply, separate chapters from Italy and the Netherlands discuss national developments in detail. The role of LNG is increasing in the European gas market. The book discusses the main components of the short-term LNG sale and purchase agreements, the rules regarding non-discriminatory access to existing regasification terminals as well as the establishment of new LNG import terminals in the EU and the extent to which such installations can be exempted from the applicable regime on regulated third-party access. The book examines several legal developments regarding energy infrastructure. Whereas the 2003 energy directives provide for a legal unbundling of the downstream energy transmission and distribution companies, some Member States (Denmark and the Netherlands) go beyond this requirement and have introduced ownership unbundling in order to guarantee the establishment of an independent system operator. Recent developments in the North Sea include the establishment of a Framework Agreement, aiming at a simplification of rules and procedures for new projects

  3. Sorption behavior of europium(III) and curium(III) on the cell surfaces of microorganisms

    Energy Technology Data Exchange (ETDEWEB)

    Ozaki, T.; Kimura, T.; Ohnuki, T.; Yoshida, Z. [Advanced Science Research Center, Japan Atomic Energy Research Inst., Ibaraki (Japan); Gillow, J.B.; Francis, A.J. [Environmental Sciences Dept., Brookhaven National Lab., Upton, NY (United States)

    2004-07-01

    We investigated the association of europium(III) and curium(III) with the microorganisms Chlorella vulgaris, Bacillus subtilis, Pseudomonas fluorescens, Halomonas sp., Halobacterium salinarum, and Halobacterium halobium. We determined the kinetics and distribution coefficients (K{sub d}) for Eu(III) and Cm(III) sorption at pH 3-5 by batch experiments, and evaluated the number of water molecules in the inner-sphere (N{sub H{sub 2}O}) and the degree of strength of ligand field (R{sub E/M}) for Eu(III) by time-resolved laser-induced fluorescence spectroscopy (TRLFS). Exudates from C. vulgaris, Halomonas sp., and H. halobium had an affinity for Eu(III) and Cm(III). The log K{sub d} of Eu(III) and Cm(III) showed that their sorption was not fully due to the exchange with three protons on the functional groups on cell surfaces. The halophilic microorganisms (Halomonas sp., Halobacterium salinarum, H. halobium) showed almost no pH dependence in log K{sub d}, indicating that an exchange with Na{sup +} on the functional groups was involved in their sorption. The {delta}N{sub H{sub 2}O} (= 9 - N{sub H{sub 2}O}) for Eu(III) on C. vulgaris was 1-3, while that for the other microorganisms was over 3, demonstrating that the coordination of Eu(III) with C. vulgaris was predominantly an outer-spherical process. The R{sub E/M} for Eu(III) on halophilic microorganisms was 2.5-5, while that for non-halophilic ones was 1-2.5. This finding suggests that the coordination environment of Eu(III) on the halophilic microorganisms is more complicated than that on the other three non-halophilic ones. (orig.)

  4. Relation between Angle Class II malocclusion and deleterious oral habits

    Directory of Open Access Journals (Sweden)

    José Tarcísio Lima Ferreira

    2012-12-01

    Full Text Available INTRODUCTION: Oral habits may interfere on the growth and development of the stomatognathic system and orofacial myofunctional conditions, producing changes in the position of teeth in their dental arches. OBJECTIVE: The purpose of this study was to verify the presence of deleterious oral habits in individuals with malocclusion and see if there is a predominance of Class II malocclusion in these individuals. METHODS: The records of 140 patients treated at the Clinic of Preventive Orthodontics FORP-USP who had already completed treatment were randomly selected and analyzed. Their ages ranged from 6 to 10 years and 11 months. Associations were made between the presence or absence of deleterious oral habits, type and number of habits found in each individual and the type of malocclusion according to Angle classification. The statistical analysis used was the Chi-square test with a significance level of 5%. History of deleterious oral habits was found in 67.1% of individuals. RESULTS: The Class I malocclusion was most frequent (82.9%, followed by Class II malocclusion (12.1% and Class III (5%. CONCLUSION: There was a predominance of Class II malocclusion in individuals with a history of deleterious oral habits.INTRODUÇÃO: hábitos bucais podem interferir no crescimento e desenvolvimento do sistema estomatognático e nas condições miofuncionais bucofaciais, acarretando alterações no posicionamento dos dentes nas respectivas arcadas dentárias. OBJETIVO: o objetivo dessa pesquisa foi verificar a presença de hábitos bucais deletérios em indivíduos portadores de má oclusão e observar se existe predominância de má oclusão Classe II de Angle nesses indivíduos. MÉTODOS: foram selecionadas, aleatoriamente, e analisadas 140 fichas de pacientes atendidos na Clínica de Ortodontia Preventiva da FORP-USP, que já haviam recebido alta no tratamento. A faixa etária variou dos 6 anos a 10 anos e 11 meses. Foram realizadas associações entre

  5. Art of Class Teaching Encourage

    Institute of Scientific and Technical Information of China (English)

    HE Jiao-fei

    2013-01-01

    Teaching encourage can lead to student’s learning motivation and interesting. It improves the effect of classroom teach⁃ing. Methods of class teaching inspiration are: Target encourage, expectation encourage, emotional encourage, positive encourage, attribution encourage, competition encourage, caress encourage, democracy encourage, praise encourage, time encourage, check en⁃courage, questions encourage, examination encourage, score encourage, example encourage and understanding encourage.

  6. COOPERATIVE LEARNING IN LARGE CLASSES

    Institute of Scientific and Technical Information of China (English)

    GuoXiangju

    2004-01-01

    Teaching college English in large classes is a new challenge to teachers. To meet this challenge, the strategy of cooperative learning is practicable. This paper introduces cooperative learning and describes the experiment results, which prove the advantages of cooperative learning over competitive learning or individualistic learning.

  7. A Class of Graceful Trees

    Institute of Scientific and Technical Information of China (English)

    孟凡洪; 苏耕; 杨继

    2000-01-01

    The present paper shows the coordinates of a tree and its vertices, defines a kind of Trees with Odd-Number Radiant Type (TONRT), deals with the gracefulness of TONRT by using the edge-moving theorem, and uses graceful TONRT to construct another class of graceful trees.

  8. Professional Elites in "Classes" Societies

    NARCIS (Netherlands)

    S.J. Magala (Slawomir)

    2003-01-01

    textabstractModern European identity has been forged in class struggles between the French revolution and fall of the Berlin Wall, which fell twice. Once, with the rest of the city in May 1945, when a national socialist alternative to a modernizing mix of parliamentary democracy and market economy c

  9. MATERIALS FOR LITERARY ENJOYMENT CLASS

    Directory of Open Access Journals (Sweden)

    Sarah Prasasti

    2000-01-01

    Full Text Available As the introductory class of literature at the Faculty of Letters, Literary Enjoyment serves as a campaign to motivate students to appreciate and enjoy works of literature. Materials, which generally hinder the students' ability to enjoy literary works, should be carefully considered. Ideally, language and content should be easily digested but a compromise can be made between language and content.

  10. Achieving world class maintenance status

    Energy Technology Data Exchange (ETDEWEB)

    Tomlingson, P.D. [Paul D. Tomingson Associates (United States)

    2007-08-15

    The article written by a management consultant, discusses the art of successful planning and operation of maintenance in mines considering factors such as benchmaking, key performance indices (KPIs) and frequency of procedures which can help achieve 'world class maintenance'. 1 fig.

  11. Social Class and School Music

    Science.gov (United States)

    Bates, Vincent C.

    2012-01-01

    This article takes a practical look at social class in school music by exploring the manifestations and impact of three of its dimensions: financial resources, cultural practices, and social networks. Three suggestions are discussed: provide a free and equal music education for all students, understand and respect each student's cultural…

  12. Understanding Class in Contemporary Societies

    DEFF Research Database (Denmark)

    Harrits, Gitte Sommer

    2007-01-01

    altogether, sociological theory runs the risk of loosing the capacity for analysing stratification and vertical differentiation of power and freedom, which in late modernity seem to be a of continuing importance. Hence, I argue that although class analysis faces a number of serious challenges, it is possible...

  13. Creative Thinking in Instrumental Classes.

    Science.gov (United States)

    Priest, Thomas

    2002-01-01

    Focuses on ways to develop student creative thinking, improvisation, and composition skills in instrumental classes. Provides suggestions, such as the importance of offering students creative opportunities, supplying examples, giving control to students, and encouraging expressive integrity. Includes a bibliography of resources for developing…

  14. Synthesis, thermal and spectroscopic behaviors of metal-drug complexes: La(III), Ce(III), Sm(III) and Y(III) amoxicillin trihydrate antibiotic drug complexes

    Science.gov (United States)

    Refat, Moamen S.; Al-Maydama, Hussein M. A.; Al-Azab, Fathi M.; Amin, Ragab R.; Jamil, Yasmin M. S.

    2014-07-01

    The metal complexes of Amoxicillin trihydrate with La(III), Ce(III), Sm(III) and Y(III) are synthesized with 1:1 (metal:Amox) molar ratio. The suggested formula structures of the complexes are based on the results of the elemental analyses, molar conductivity, (infrared, UV-visible and fluorescence) spectra, effective magnetic moment in Bohr magnetons, as well as the thermal analysis (TG), and characterized by X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). The results obtained suggested that Amoxicillin reacted with metal ions as tridentate ligands, coordinating the metal ion through its amino, imino, and β-lactamic carbonyl. The kinetic thermodynamic parameters such as: Ea, ΔH*, ΔS* and ΔG* were estimated from the DTG curves.

  15. Mode III effects on interface delamination

    DEFF Research Database (Denmark)

    Tvergaard, Viggo; Hutchinson, J.W.

    2008-01-01

    mode III has an effect. Subsequently, the focus is on crack growth along an interface between an elastic-plastic solid and an elastic substrate. The analyses are carried out for conditions of small-scale yielding, with the fracture process at the interface represented by a cohesive zone model. Due...... to the mismatch of elastic properties across the interface the corresponding elastic solution has an oscillating stress singularity, and this solution is applied as boundary conditions on the outer edge of the region analyzed. For several combinations of modes I, II and III crack growth resistance curves......For crack growth along an interface between dissimilar materials the effect of combined modes I, II and III at the crack-tip is investigated. First, in order to highlight situations where crack growth is affected by a mode III contribution, examples of material configurations are discussed where...

  16. III Advanced Ceramics and Applications Conference

    CERN Document Server

    Gadow, Rainer; Mitic, Vojislav; Obradovic, Nina

    2016-01-01

    This is the Proceedings of III Advanced Ceramics and Applications conference, held in Belgrade, Serbia in 2014. It contains 25 papers on various subjects regarding preparation, characterization and application of advanced ceramic materials.

  17. Potentiometry: A Chromium (III) -- EDTA Complex

    Science.gov (United States)

    Hoppe, J. I.; Howell, P. J.

    1975-01-01

    Describes an experiment that involves the preparation of a chromium (III)-EDTA compound, a study of its infrared spectrum, and the potentiometric determination of two successive acid dissociation constants. (Author/GS)

  18. Fast Exact Euclidean Distance (FEED): A New Class of Adaptable Distance Transforms.

    Science.gov (United States)

    Schouten, Theo E; van den Broek, Egon L

    2014-11-01

    A new unique class of foldable distance transforms of digital images (DT) is introduced, baptized: Fast exact euclidean distance (FEED) transforms. FEED class algorithms calculate the DT starting-directly from the definition or rather its inverse. The principle of FEED class algorithms is introduced, followed by strategies for their efficient implementation. It is shown that FEED class algorithms unite properties of ordered propagation, raster scanning, and independent scanning DT. Moreover, FEED class algorithms shown to have a unique property: they can be tailored to the images under investigation. Benchmarks are conducted on both the Fabbri et al. data set and on a newly developed data set. Three baseline, three approximate, and three state-of-the-art DT algorithms were included, in addition to two implementations of FEED class algorithms. It illustrates that FEED class algorithms i) provide truly exact Euclidean DT; ii) do no suffer from disconnected Voronoi tiles, which is a unique feature for non-parallel but fast DT; iii) outperform any other approximate and exact Euclidean DT with its time complexity O(N), even after their optimization; and iv) are unequaled in that they can be adapted to the characteristics of the image class at hand.

  19. Class Action Suits against Public Schools.

    Science.gov (United States)

    Mesibov, Laurie

    1984-01-01

    If a suit is brought as a class action, either plaintiff or defendant may move to uphold or challenge class certification. If neither does so, the court decides whether the action may be maintained as a class suit. Prerequisites for class certification from Rule 23 (Federal Rules of Civil Procedure) are explained. (TE)

  20. Student versus Faculty Perceptions of Missing Class.

    Science.gov (United States)

    Sleigh, Merry J.; Ritzer, Darren R.; Casey, Michael B.

    2002-01-01

    Examines and compares student and faculty attitudes towards students missing classes and class attendance. Surveys undergraduate students (n=231) in lower and upper level psychology courses and psychology faculty. Reports that students found more reasons acceptable for missing classes and that the amount of in-class material on the examinations…

  1. Making the Introductory Journalism Class Tick.

    Science.gov (United States)

    Dorway, Tim

    2003-01-01

    Proposes that beginning journalism classes teach multiple skills, including law, decision-making, interpersonal communication, interviewing, and critical thinking. Outlines how to convince administrators of the need for beginning journalism classes, and how to develop an effective class. Lists philosophy and course goals for one such class. (PM)

  2. Population III stars around the Milky Way

    CERN Document Server

    Komiya, Yutaka; Fujimoto, Masayuki Y

    2016-01-01

    We explore the possibility of observing Population III (Pop~III) stars, born of the primordial gas. Pop~III stars with masses below $0.8 M_\\odot$ should survive to date though are not observed yet, but the existence of stars with low metallicity as [Fe/H]$ < -5$ in the Milky Way halo suggests the surface pollution of Pop~III stars with accreted metals from the interstellar gas after birth. In this paper, we investigate the runaway of Pop~III stars from their host mini-halos, considering the ejection of secondary members from binary systems when their massive primaries explode as supernovae. These stars save them from the surface pollution. By computing the star formation and chemical evolution along with the hierarchical structure formation based on the extended Press--Schechter merger trees, we demonstrate that several hundreds to tens of thousands of low-mass Pop~III stars escape from the building blocks of the Milky Way. The second and later generations of extremely metal-poor (EMP) stars are also escap...

  3. Arsenic(III Immobilization on Rice Husk

    Directory of Open Access Journals (Sweden)

    Malay Chaudhuri

    2013-02-01

    Full Text Available A number of large aquifers in various parts of the world have been identified with contamination by arsenic. Long-term exposure to arsenic in drinking water causes cancer of the skin, lungs, urinary bladder and kidney, as well as skin pigmentation and hyperkeratosis. Arsenic occurs in groundwater in two valence states, as trivalent arsenite [As(III] and pentavalent arsenate [As(V]. As(III is more toxic and more difficult to remove from water by adsorption on activated alumina. In this study, immobilization (adsorption of As(III by quaternized rice husk was examined. Batch adsorption test showed that extent of adsorption was dependent on pH, As (III concentration, contact time and rice husk dose. Maximum adsorption occurred at pH 7-8, and equilibrium adsorption was attained in 2 h. Equilibrium adsorption data were described by the Langmuir and Freundlich isotherm models. According to the Langmuir isotherm, adsorption capacity of quaternized rice husk is 0.775 mg As(III/g, which is 4.3x higher than that (0.180 mg As(III/g of activated alumina. Quaternized rice husk is a potentially useful adsorbent for removing arsenic from groundwater.

  4. Lanthanum(III) and praseodymium(III) derivatives with dithiocarbamates derived from α-amino acids

    Science.gov (United States)

    Rai, Anita; Sengupta, Soumitra K.; Pandey, Om P.

    2006-06-01

    Lanthanum(III) and praseodymium(III) complexes with dithiocarbamates have been synthesized by the reactions of lanthanum(III) and praseodymium(III) chloride with barium dithiocarbamate and complexes of type [LnCl(L)H 2O] n have been obtained (where Ln = La(III) or Pr(III); L = barium salt of dithiocarbamate derived from glycine, L-leucine, L-valine, DL-alanine). The complexes have been characterized by elemental analysis, molar conductance, electronic absorption and fluorescence, infrared, far infrared, 1H NMR spectral studies. The presence of coordinated water molecule is inferred from thermogravimetric analysis which indicates the loss of one water molecule at 150-170 °C. The oscillator strength, Judd-Ofelt intensity parameter, stimulated emission cross-section, etc. have been obtained for different transitions of Pr 3+.

  5. Gallium(iii) and iron(iii) complexes of quinolone antimicrobials.

    Science.gov (United States)

    Mjos, Katja Dralle; Cawthray, Jacqueline F; Polishchuk, Elena; Abrams, Michael J; Orvig, Chris

    2016-08-16

    Iron is an essential nutrient for many microbes. According to the "Trojan Horse Hypothesis", biological systems have difficulties distinguishing between Fe(3+) and Ga(3+), which constitutes the antimicrobial efficacy of the gallium(iii) ion. Nine novel tris(quinolono)gallium(iii) complexes and their corresponding iron(iii) analogs have been synthesized and fully characterized. Quinolone antimicrobial agents from three drug generations were used in this study: ciprofloxacin, enoxacin, fleroxacin, levofloxacin, lomefloxacin, nalidixic acid, norfloxacin, oxolinic acid, and pipemidic acid. The antimicrobial efficacy of the tris(quinolono)gallium(iii) complexes was studied against E. faecalis and S. aureus (both Gram-positive), as well as E. coli, K. pneumonia, and P. aeruginosa (all Gram-negative) in direct comparison to the tris(quinolono)iron(iii) complexes and the corresponding free quinolone ligands at various concentrations. For the tris(quinolono)gallium(iii) complexes, no combinational antimicrobial effects between Ga(3+) and the quinolone antimicrobial agents were observed. PMID:27315225

  6. Development of WAIS-III General Ability Index Minus WMS-III memory discrepancy scores.

    Science.gov (United States)

    Lange, Rael T; Chelune, Gordon J; Tulsky, David S

    2006-09-01

    Analysis of the discrepancy between intellectual functioning and memory ability has received some support as a useful means for evaluating memory impairment. In recent additions to Wechlser scale interpretation, the WAIS-III General Ability Index (GAI) and the WMS-III Delayed Memory Index (DMI) were developed. The purpose of this investigation is to develop base rate data for GAI-IMI, GAI-GMI, and GAI-DMI discrepancy scores using data from the WAIS-III/WMS-III standardization sample (weighted N = 1250). Base rate tables were developed using the predicted-difference method and two simple-difference methods (i.e., stratified and non-stratified). These tables provide valuable data for clinical reference purposes to determine the frequency of GAI-IMI, GAI-GMI, and GAI-DMI discrepancy scores in the WAIS-III/WMS-III standardization sample.

  7. Trabalho e classes sociais Work and social classes

    Directory of Open Access Journals (Sweden)

    Fernando Haddad

    1997-10-01

    Full Text Available Exposição, discussão e refutação das principais tentativas de atualizar a teoria marxista de classes e posterior reavaliação dessa teoria à luz da transformação da ciência em fator de produção e da possível perda de centralidade do trabalho no processo produtivo, tendo por base as interpretações lógicas da obra de Marx feitas por Ruy Fausto.Exposition, discussion and refutation of the main attempts of actualizing marxist class theory and a posterior reevaluation of this theory taking into account the transformation of Science into a factor of production and of the possible centrality-loss of work in the productive process, based on the logic interpretations of Marx's work made by Ruy Fausto.

  8. HVEM serial-section analysis of rabbit foliate taste buds: I. Type III cells and their synapses.

    Science.gov (United States)

    Royer, S M; Kinnamon, J C

    1991-04-01

    Serially sectioned rabbit foliate taste buds were examined with high voltage electron microscopy (HVEM) and computer-assisted, three-dimensional reconstruction. This report focuses on the ultrastructure of the type III cells and their synapses with sensory nerve fibers. Type III cells have previously been proposed to be the primary gustatory receptor cells in taste buds of rabbits and other mammals. Within rabbit foliate taste buds, type III cells constitute a well-defined, easily recognizable class and are the only taste bud cells observed to form synapses with intragemmal nerve fibers. Among 18 type III cells reconstructed from serial sections, 11 formed from 1 to 6 synapses each with nerve fibers; 7 reconstructed type III cells formed no synapses. Examples of both convergence and divergence of synaptic input from type III cells onto nerve fibers were observed. The sizes of the active zones of the synapses and numbers of vesicles associated with the presynaptic membrane specializations were highly variable. Dense-cored vesicles 80-140 nm in diameter were often found among the 40-60 nm clear vesicles clustered at presynaptic sites. At some synapses, these large dense-cored vesicles appeared to be the predominant vesicle type. This observation suggests that there may be functionally different types of synapses in taste buds, distinguished by the prevalence of either clear or dense-cored vesicles. Previous investigations have indicated that the dense-cored vesicles in type III cells may be storage sites for biogenic amines.

  9. AIPS++ N-Dimensional Array Classes

    Directory of Open Access Journals (Sweden)

    A. G. Willis

    1993-01-01

    Full Text Available This article describes a set of C++ classes developed for the AIPS++ project. These classes handle arrays having an arbitrary number of dimensions. We give an overview of the methods available in these classes and show some simple examples of their use. Finally we describe the use of these classes to develop a radio astronomy application and discuss some of the performance issues that must be considered when these classes are used.

  10. Stochastic prediction of drought class transitions

    OpenAIRE

    Paulo, Ana A.; L. S. Pereira

    2008-01-01

    This paper aims at the stochastic characterization of droughts applying Markov chains modeling to drought class transitions derived from SPI time series. Several sites in Southern Portugal having updated data on precipitation available were considered. The drought class probabilities, the expected residence time in each class of severity, the expected time for the transition between drought classes and the drought severity class predictions 1, 2, or 3 months ahead have been obt...

  11. FDM Video Classe: Modes d'emploi pour la classe (FDM Video Class: Classroom Uses).

    Science.gov (United States)

    Beacco, Marcella Di Giura

    1996-01-01

    Content and design of the videotape series FDM Video Classe, produced by the journal "Le francais dans le monde," are described and classroom uses suggested. The materials are from authentic television programs, selected to illustrate aspects of French culture. It is suggested that the teacher also provide students with supporting materials that…

  12. WISC-III e WAIS-III na avaliação da inteligência de cegos WISC-III/WAIS-III en ciegos WISC-III and WAIS-III in intellectual assessment of blind people

    Directory of Open Access Journals (Sweden)

    Elizabeth do Nascimento

    2007-12-01

    Full Text Available Diante da escassez de pesquisas nacionais e de testes psicológicos destinados a avaliar pessoas cegas, desenvolveu-se um estudo psicométrico com as escalas verbais dos testes WISC-III e WAIS-III. Após as adaptações de alguns estímulos e das instruções, os testes foram aplicados em crianças (N = 120 e adultos (N = 52 residentes em Belo Horizonte. Os resultados indicaram que as escalas verbais modificadas apresentam uma boa consistência interna (alfa> 0,80. Além disso, a investigação da validade fatorial identifica a presença clara de apenas um componente. Este componente explica 81% e 64% para o WISC-III e WAIS-III, respectivamente. Conclui-se que as adaptações a que se procedeu não afetaram a estrutura fatorial das escalas. Deste modo, os profissionais poderão utilizar as escalas modificadas para avaliar a inteligência de pessoas cegas.Frente a la escasez de investigaciones nacionales asi como la ausencia de tests psicológicos que evaluen personas ciegas, se ha desarrollado un estudio psicometrico com la escalas verbales del WISC-III y WAIS-III. Posteriormente a las adaptaciones de algunos estímulos y de las instrucciones, las escalas fueron aplicadas a una muestra de niños (n=120 y de adultos (n=52 residentes en la ciudad de Belo Horizonte-Brasil. Los resultados indican que las escalas verbales modificadas presentan una alta fiabilidad (alpha >0,80 asi como la presencia clara de un unico componente responsable por 81% y 64% de la variancia del WIC-III e WAIS-III respectivamente. Se ha concluido que las modificaciones efectuadas no han comprometido la estructura factorial de las escalas verbales. Por tanto, los profesionales psicólogos pueden utilizar las escalas modificadas para la evaluación de la inteligencia de personas portadoras de ceguera.Owing to the almost lack of a national research on psychological testing for the evaluation of blind people, a psychometric study has been developed with the WISC-III and WAIS-III

  13. WAIS-III and WMS-III profiles of mildly to severely brain-injured patients.

    Science.gov (United States)

    Fisher, D C; Ledbetter, M F; Cohen, N J; Marmor, D; Tulsky, D S

    2000-01-01

    Wechsler Adult Intelligence Scale-III (WAIS-III) and Wechsler Memory Scale-III (WMS-III; The Psychological Corporation, 1997) scores of patients with mild traumatic brain injury (MTBI, n = 23) to moderate-severe traumatic brain injury (M-S TBI, n = 22) were compared to those of 45 matched normal control patients. WAIS-III results revealed that IQ and index scores of MTBI patients did not significantly differ from those of controls, whereas M-S TBI patients received significantly lower mean scores on all measures. All M-S TBI patients' WMS-III index scores also revealed significantly lower scores in comparison to those of control participants, with the exception of Delayed Auditory Recognition. MTBI patients showed significantly lower mean index scores compared to normal controls on measures of immediate and delayed auditory memory, immediate memory, visual delayed memory, and general memory. Eta-squared analyses revealed that WMS-III visual indexes and WAIS-III processing speed showed particularly large effect sizes. These results suggest that symptomatic MTBI patients obtain some low WMS-III test scores comparable to those of more severely injured patients.

  14. Lanthanides(III)/Actinides(III) separation by nano-filtration-complexation

    International Nuclear Information System (INIS)

    The aim of this work is to evaluate the lanthanides (III) separation by nano-filtration complexation according to the pH (1.0-4.0) with poly-amino-carboxylic acids as complexing agent. The experimental Ln(III) complex rejections were then compared to Ln(III)-Ligand system speciation calculated using the protonation and thermodynamic stability constants. Some differences were revealed for lower (pH 1.0) and higher (pH 4.0) Ln(III) complex rejections. These differences of the Ln(III) complex rejections could be explained by a combination of both steric exclusion and surface force interactions. At pH 1.0, the initial experimental rejection of the free Ln(III) reaches 6% in absence of complexation because the membrane is positively charged. In order to limit the escape in Ln(III) complexes at pH 4.0, the influence of the operating parameters was studied. At pH 5.8 and for an operational pressure of 3 bars, a complex concentration of 0.4 mM, a tangential velocity of 145 mm.s-1 and a temperature of 15 deg C, the Gd(III) complex rejection reached more than 99% and thus the total Gd(III) complex in the feed is rejected. (authors)

  15. The Fermilab physics class library

    International Nuclear Information System (INIS)

    The Fermilab Physics Class Library Task Force has been formed to supply classes and utilities, primarily in support of efforts by CDF and D0 toward using C++. A collection of libraries and tools will be assembled via development by the task force, collaboration with other HEP developers, and acquisition of existing modules. The main emphasis is on a kit of resources which physics coders can incorporate into their programs, with confidence in robustness and correct behavior. The task force is drawn from CDF, DO and the FNAL Computing and Beams Divisions. Modules-containers, linear algebra, histograms, etc.-have been assigned priority, based on immediate Run II coding activity, and will be available at times ranging from now to late May

  16. A Transformer Class E Amplifier

    Directory of Open Access Journals (Sweden)

    Mikolajewski Miroslaw

    2014-12-01

    Full Text Available In a high-efficiency Class E ZVS resonant amplifier a matching and isolation transformer can replace some or even all inductive components of the amplifier thus simplifying the circuit and reducing its cost. In the paper a theoretical analysis, a design example and its experimental verification for a transformer Class E amplifier are presented. In the experimental amplifier with a transformer as the only inductive component in the circuit high efficiency ηMAX = 0.95 was achieved for supply voltage VI = 36 V, maximum output power POMAX = 100 W and the switching frequency f = 300 kHz. Measured parameters and waveforms showed a good agreement with theoretical predictions. Moreover, the relative bandwidth of the switching frequency was only 19% to obtain output power control from 4.8 W to POMAX with efficiency not less than 0.9 in the regulation range.

  17. Exploitation and the class struggle

    OpenAIRE

    Juan Carlos Cuestas; Bruce Philp

    2010-01-01

    This paper contributes to our understanding of the determinants and dynamics of Marxian exploitation using quarterly UK data, 1955-2008. Initially a simple model is introduced for the purpose of defining exploitation and its component parts, before elaborating on theoretical issues which are important in estimating the rate of exploitation. In the empirical analysis we seek to explain the effect of class struggle, for the UK economy, using quarterly data. Attention is paid to three forces whi...

  18. Promoting Wellness in Lamaze Classes

    OpenAIRE

    Hotelling, Barbara A.

    2005-01-01

    Lamaze childbirth educators are responsible for teaching wellness-based classes that do not add to the anxiety of the current, fear-based culture of maternity health care. Expectant parents' vulnerable months of pregnancy offer “teachable moments” for the childbirth educator, during which parents can be encouraged to alter their lifestyles and adopt the concept of wellness to their principles of living. In this article, concepts of wellness are examined, drawing from the writings of wellness ...

  19. Collective Identity and Social Class

    Directory of Open Access Journals (Sweden)

    Juan Carlos Seoane

    2008-01-01

    Full Text Available This article focuses on the constitution of social identities and the influence that social class has had on understanding social identities. Different perspectives on the debate over the Marxist idea of social subject are discussed. Finally, recent perspectives are analyzed. These perspectives show two related issues: the disappearance of Marxist subjects as a result of economic, political and labor changes, and the emergence of radically different theoretical approaches to the constitution of social subjects.

  20. Social Identity and Class Consciousness

    OpenAIRE

    Hanappi, Hardy; Hanappi-Egger, Edeltraud

    2014-01-01

    The current economic crisis proves how deep the contradictions inherent in contemporary capitalism really are. At the same time it is evident that the financial crisis goes hand in hand with a social crisis, since an increasing number of people lost trust in governments, trade unions and other representative institutions. A main reason why the European Left nevertheless faces severe challenges in attracting supporters seems to be an experienced loss of what has been called ‘working class ...

  1. 76 FR 50436 - Class II Gaming Regulation Proposals Submitted by Poarch Band of Creek Indians on Behalf of...

    Science.gov (United States)

    2011-08-15

    ...; ] DEPARTMENT OF THE INTERIOR National Indian Gaming Commission 25 CFR Chapter III Class II Gaming Regulation Proposals Submitted by Poarch Band of Creek Indians on Behalf of Tribal Gaming Working Group AGENCY: National Indian Gaming Commission, Interior. ACTION: Request for comments. SUMMARY: The National...

  2. Role of PU.1 in MHC Class II Expression via CIITA Transcription in Plasmacytoid Dendritic Cells.

    Science.gov (United States)

    Miura, Ryosuke; Kasakura, Kazumi; Nakano, Nobuhiro; Hara, Mutsuko; Maeda, Keiko; Okumura, Ko; Ogawa, Hideoki; Yashiro, Takuya; Nishiyama, Chiharu

    2016-01-01

    The cofactor CIITA is a master regulator of MHC class II expression and several transcription factors regulating the cell type-specific expression of CIITA have been identified. Although the MHC class II expression in plasmacytoid dendritic cells (pDCs) is also mediated by CIITA, the transcription factors involved in the CIITA expression in pDCs are largely unknown. In the present study, we analyzed the role of a hematopoietic lineage-specific transcription factor, PU.1, in CIITA transcription in pDCs. The introduction of PU.1 siRNA into mouse pDCs and a human pDC cell line, CAL-1, reduced the mRNA levels of MHC class II and CIITA. When the binding of PU.1 to the 3rd promoter of CIITA (pIII) in CAL-1 and mouse pDCs was analyzed by a chromatin immunoprecipitation assay, a significant amount of PU.1 binding to the pIII was detected, which was definitely decreased in PU.1 siRNA-transfected cells. Reporter assays showed that PU.1 knockdown reduced the pIII promoter activity and that three Ets-motifs in the human pIII promoter were candidates of cis-enhancing elements. By electrophoretic mobility shift assays, it was confirmed that two Ets-motifs, GGAA (-181/-178) and AGAA (-114/-111), among three candidates, were directly bound with PU.1. When mouse pDCs and CAL-1 cells were stimulated by GM-CSF, mRNA levels of PU.1, pIII-driven CIITA, total CIITA, MHC class II, and the amount of PU.1 binding to pIII were significantly increased. The GM-CSF-mediated up-regulation of these mRNAs was canceled in PU.1 siRNA-introduced cells. Taking these results together, we conclude that PU.1 transactivates the pIII through direct binding to Ets-motifs in the promoter in pDCs.

  3. Class Transitions in Black Holes

    CERN Document Server

    Chakrabarti, S K

    2005-01-01

    A black hole spectrum is known to change from the hard state to the soft state when the energy spectral index $\\alpha$ ($F_E \\propto E^{-\\alpha}$) in, say, 2-20 keV range changes from $\\alpha \\sim 0.5$ to $\\sim 1.5$. However, this `classical' definition which characterizes black holes like Cyg X-1, becomes less useful for many objects such as GRS 1915+105 in which the spectral slope is seen to vary from one to the other in a matter of seconds and depending on whether or not winds form, the spectral slope also changes. The light curves and the colour-colour diagrams may look completely different on different days depending on the frequency and mode of switching from one spectral state to the other. Though RXTE observations have yielded wealth of information on such `variability classes' in GRS 1915+105, very rarely one has been able to observe how the object goes from one class to the other. In the present review, we discuss possible origins of the class transition and present several examples of such transiti...

  4. Association of Eu(III) and Cm(III) With Halophiles

    Science.gov (United States)

    Ozaki, T.; Takenaka, Y.; Ohnuki, T.; Gillow, J. B.; Francis, A. J.

    2003-12-01

    Halophiles live in high ionic strength brine. The mechanisms of metal association with these microorganisms are poorly understood. In this study, we determined the distribution of Eu(III) and Cm(III) on halophiles, Halomonas sp. (WIPP1A) which was isolated from the Waste Isolation Pilot Plant (WIPP) repository in Carlsbad, US., Halomonas elongata (ATCC33173), Halobacterium salinarum (ATCC19700), and Halobacterium halobium (ATCC43214) and examined the coordination environment of Eu(III) adsorbed on the cells by time-resolved laser-induced fluorescence spectroscopy (TRLFS). The cells of Halomonas sp. and H. elongata were grown in media containing 10 - 15 w/v% and 3.5 - 30 w/v% NaCl, respectively. Halobacterium salinarum and H. halobium were grown in media containing 25 w/v% NaCl. The logarithmic distribution coefficient (log Kd) was measured by using the cells at the late exponential phase. After washing the cells with the same concentrations of NaCl, the cells were mixed with 1x10-6 mol dm-3 Eu(III) and 1x10-8 mol dm-3 Cm(III) at pH 5 in the same concentrations of NaCl and log Kd of Eu(III) and Cm(III) was determined. For Halomonas sp. and H. elongata, log Kd was determined as a function of NaCl concentrations. The coordination environment of Eu(III) adsorbed on the cells was estimated by TRLFS. For TRLFS measurements, samples were prepared by adding cells to a solution of 1x10-3 mol dm-3 Eu(III) with the same concentrations of NaCl as the culture media. For Halomonas sp. and H. elongata, log Kd of Cm(III) was apparently larger than that of Eu(III) at all the NaCl concentrations examined. On the other hand, log Kd of Eu(III) and Cm(III) for H. salinarum and H. halobium was almost identical. Our previous study demonstrated that non-halophiles, Chlorella vulgaris, Bacillus subtilis, and Pseudomonas fluorescens show no preferences between these elements. Chemical properties of Eu(III) and Cm(III) are almost identical. Our findings suggest that the difference in log Kd

  5. Hybrid III-V/silicon lasers

    Science.gov (United States)

    Kaspar, P.; Jany, C.; Le Liepvre, A.; Accard, A.; Lamponi, M.; Make, D.; Levaufre, G.; Girard, N.; Lelarge, F.; Shen, A.; Charbonnier, P.; Mallecot, F.; Duan, G.-H.; Gentner, J.-.; Fedeli, J.-M.; Olivier, S.; Descos, A.; Ben Bakir, B.; Messaoudene, S.; Bordel, D.; Malhouitre, S.; Kopp, C.; Menezo, S.

    2014-05-01

    The lack of potent integrated light emitters is one of the bottlenecks that have so far hindered the silicon photonics platform from revolutionizing the communication market. Photonic circuits with integrated light sources have the potential to address a wide range of applications from short-distance data communication to long-haul optical transmission. Notably, the integration of lasers would allow saving large assembly costs and reduce the footprint of optoelectronic products by combining photonic and microelectronic functionalities on a single chip. Since silicon and germanium-based sources are still in their infancy, hybrid approaches using III-V semiconductor materials are currently pursued by several research laboratories in academia as well as in industry. In this paper we review recent developments of hybrid III-V/silicon lasers and discuss the advantages and drawbacks of several integration schemes. The integration approach followed in our laboratory makes use of wafer-bonded III-V material on structured silicon-on-insulator substrates and is based on adiabatic mode transfers between silicon and III-V waveguides. We will highlight some of the most interesting results from devices such as wavelength-tunable lasers and AWG lasers. The good performance demonstrates that an efficient mode transfer can be achieved between III-V and silicon waveguides and encourages further research efforts in this direction.

  6. Failures in Phase III: Causes and Consequences.

    Science.gov (United States)

    Seruga, Bostjan; Ocana, Alberto; Amir, Eitan; Tannock, Ian F

    2015-10-15

    Phase III randomized controlled trials (RCT) in oncology fail to lead to registration of new therapies more often than RCTs in other medical disciplines. Most RCTs are sponsored by the pharmaceutical industry, which reflects industry's increasing responsibility in cancer drug development. Many preclinical models are unreliable for evaluation of new anticancer agents, and stronger evidence of biologic effect should be required before a new agent enters the clinical development pathway. Whenever possible, early-phase clinical trials should include pharmacodynamic studies to demonstrate that new agents inhibit their molecular targets and demonstrate substantial antitumor activity at tolerated doses in an enriched population of patients. Here, we review recent RCTs and found that these conditions were not met for most of the targeted anticancer agents, which failed in recent RCTs. Many recent phase III RCTs were initiated without sufficient evidence of activity from early-phase clinical trials. Because patients treated within such trials can be harmed, they should not be undertaken. The bar should also be raised when making decisions to proceed from phase II to III and from phase III to marketing approval. Many approved agents showed only better progression-free survival than standard treatment in phase III trials and were not shown to improve survival or its quality. Introduction of value-based pricing of new anticancer agents would dissuade the continued development of agents with borderline activity in early-phase clinical trials. When collaborating with industry, oncologists should be more critical and better advocates for cancer patients. PMID:26473191

  7. Sensitivity and specificity of WAIS-III/WMS-III demographically corrected factor scores in neuropsychological assessment.

    Science.gov (United States)

    Taylor, M J; Heaton, R K

    2001-11-01

    This study explored the neurodiagnostic utility of 6 factor scores identified by recent exploratory and confirmatory factor analyses of the WAIS-III and WMS-III: Verbal Comprehension, Perceptual Organization, Processing Speed, Working Memory, Auditory Memory and Visual Memory. Factor scores were corrected for age. education, sex and ethnicity to minimize their influences on diagnostic accuracy. Cut-offs at 1, 1.5 and 2 standard deviations (SDs) below the standardization sample mean were applied to data from the overlapping test normative samples (N = 1073) and 6 clinical samples described in the WAIS-III/WMS-III Technical Manual (N = 126). The analyses suggest that a I SD cut-off yields the most balanced levels of sensitivity and specificity; more strict (1.5 or 2 SD) cut-offs generally result in trading modest gains in specificity for larger losses in sensitivity. Finally, using combinations of WAIS-III/WMS-III factors together as test batteries, we explored the sensitivity and specificity implications of varying diagnostic decision rules (e.g.,1 vs. 2 impaired factors = "impairment"). For most of the disorders considered here, even a small (e.g., 3 factor) WAIS-III/WMS-III battery provides quite good overall diagnostic accuracy.

  8. Synthesis, crystal structure and magnetism of iron(III) and manganese(III) dipicolinates with pyridinemethanols

    Science.gov (United States)

    Uhrecký, Róbert; Pavlik, Ján; Růžičková, Zdeňka; Dlháň, Ľubor; Koman, Marian; Boča, Roman; Moncoľ, Ján

    2014-11-01

    Four ionic iron(III) and manganese(III) dipicolinato complexes of the formula (2-pymeH) [FeIII(dipic)2]ṡ[FeIII(H2O)2Cl(dipic)]ṡ2H2O, (3-pymeH)[MnIII(dipic)2]ṡ1.5H2O, (4-pymeH)[FeIII(dipic)2]ṡ2H2O and (4-pymeH)[MnIII(dipic)2]ṡ2H2O, where H2dipic = pyridine-2,6-dicarboxylic acid, 2-pyme = 2-pyridinemethanol, 3-pyme = 3-pyridinemethanol, 4-pyme = 4-pyridinemethanol, have been prepared and characterized by the single-crystal X-ray structure analysis, infrared spectroscopy and magnetic measurements. The magnetic data were fitted to a zero-field splitting model revealing a slight magnetic anisotropy for Mn(III) systems. The molecular field correction was consistently formulated and included in the analysis for both, magnetic susceptibility and magnetization data.

  9. Do class size effects differ across grades?

    DEFF Research Database (Denmark)

    Nandrup, Anne Brink

    This paper contributes to the class size literature by analyzing whether short-run class size effects are constant across grade levels in compulsory school. Results are based on administrative data on all pupils enroled in Danish public schools. Identification is based on a government-imposed class...... size cap that creates exogenous variation in class sizes. Significant (albeit modest) negative effects of class size increases are found for children on primary school levels. The effects on math abilities are statistically different across primary and secondary school. Larger classes do not affect...

  10. Psychometric Testing of the FACES III with Rural Adolescents

    Science.gov (United States)

    Ide, Bette; Dingmann, Colleen; Cuevas, Elizabeth; Meehan, Maurita

    2010-01-01

    This study tests the validity and reliability of the Family Adaptability and Cohesion Scale III (FACES III) in two samples of rural adolescents. The underlying theory is the linear 3-D circumplex model. The FACES III was administered to 1,632 adolescents in Grades 7 through 12 in two counties in a rural western state. The FACES III Scale and the…

  11. BALTICA III. Plant condition and life management

    International Nuclear Information System (INIS)

    The BALTICA III, International Conference on Plant Condition and Life Management was held on June 6 - 8, 1995 on board Silja Serenade on its cruise between Helsinki - Stockholm and at the Forest Lake Hotel Korpilampi in Espoo. BALTICA III provides forum for the transfer of technology from applied research to practise. This is the second volume of the publications, which contain the presentations given at the BALTICA III, Plant Condition and Life Management. A total of 45 articles report recent experience in plant condition and life management. The conference focuses on recent applications that have been demonstrated for the benefit of safe and economical operation of power plants. Practical approach is emphasised, including the presentations that aim to provide insight into new techniques, improvements in assessment methodologies as well as maintenance strategies. Compared to earlier occasions in the BALTICA series, a new aspect is in the applications of knowledge-based systems in the service of power plant life management. (orig.)

  12. SAGE III aerosol extinction validation in the Arctic winter: comparisons with SAGE II and POAM III

    Directory of Open Access Journals (Sweden)

    L. W. Thomason

    2006-11-01

    Full Text Available The use of SAGE III multiwavelength aerosol extinction coefficient measurements to infer PSC type is contingent on the robustness of both the extinction magnitude and its spectral variation. Past validation with SAGE II and other similar measurements has shown that the SAGE III extinction coefficient measurements are reliable though the comparisons have been greatly weighted toward measurements made at mid-latitudes. Some aerosol comparisons made in the Arctic winter as a part of SOLVE II suggested that SAGE III values, particularly at longer wavelengths, are too small with the implication that both the magnitude and the wavelength dependence are not reliable. Comparisons with POAM III have also suggested a similar discrepancy. Herein, we use SAGE II data as a common standard for comparison of SAGE III and POAM III measurements in the Arctic winters of 2002/2003 through 2004/2005. During the winter, SAGE II measurements are made infrequently at the same latitudes as these instruments. We have mitigated this problem through the use potential vorticity as a spatial coordinate and thus greatly increased the number of coincident events. We find that SAGE II and III extinction coefficient measurements show a high degree of compatibility at both 1020 nm and 450 nm except a 10–20% bias at both wavelengths. In addition, the 452 to 1020 nm extinction ratio shows a consistent bias of ~30% throughout the lower stratosphere. We also find that SAGE II and POAM III are on average consistent though the comparisons show a much higher variability and larger bias than SAGE II/III comparisons. In addition, we find that the two data sets are not well correlated below 18 km. Overall, we find both the extinction values and the spectral dependence from SAGE III are robust and we find no evidence of a significant defect within the Arctic vortex.

  13. SAGE III Aerosol Extinction Validation in the Arctic Winter: Comparisons with SAGE II and POAM III

    Science.gov (United States)

    Thomason, L. W.; Poole, L. R.; Randall, C. E.

    2007-01-01

    The use of SAGE III multiwavelength aerosol extinction coefficient measurements to infer PSC type is contingent on the robustness of both the extinction magnitude and its spectral variation. Past validation with SAGE II and other similar measurements has shown that the SAGE III extinction coefficient measurements are reliable though the comparisons have been greatly weighted toward measurements made at mid-latitudes. Some aerosol comparisons made in the Arctic winter as a part of SOLVE II suggested that SAGE III values, particularly at longer wavelengths, are too small with the implication that both the magnitude and the wavelength dependence are not reliable. Comparisons with POAM III have also suggested a similar discrepancy. Herein, we use SAGE II data as a common standard for comparison of SAGE III and POAM III measurements in the Arctic winters of 2002/2003 through 2004/2005. During the winter, SAGE II measurements are made infrequently at the same latitudes as these instruments. We have mitigated this problem through the use potential vorticity as a spatial coordinate and thus greatly increased the number of coincident events. We find that SAGE II and III extinction coefficient measurements show a high degree of compatibility at both 1020 nm and 450 nm except a 10-20% bias at both wavelengths. In addition, the 452 to 1020-nm extinction ratio shows a consistent bias of approx. 30% throughout the lower stratosphere. We also find that SAGE II and POAM III are on average consistent though the comparisons show a much higher variability and larger bias than SAGE II/III comparisons. In addition, we find that the two data sets are not well correlated below 18 km. Overall, we find both the extinction values and the spectral dependence from SAGE III are robust and we find no evidence of a significant defect within the Arctic vortex.

  14. What is Middle Class about the Middle Classes Around the World?

    OpenAIRE

    Banerjee, Abhijit V.; Esther Duflo

    2007-01-01

    We expect a lot from the middle classes. At least three distinct arguments about the special economic role of the middle class are traditionally made. In one, new entrepreneurs armed with a capacity and a tolerance for delayed gratification emerge from the middle class and create employment and productivity growth for the rest of society. In a second, perhaps more conventional view, the middle class is primarily a source of vital inputs for the entrepreneurial class: it is their "middle class...

  15. 4- vs. 5-phenylquinolinolate aluminum (III) isomers

    International Nuclear Information System (INIS)

    A method for the synthesis of 4-arylquinolinolate ligand and their AlIII complexes based on Michael reaction of 2-methoxyaniline with 1-phenylpropenones was developed. The resulting 4-aryl-8-methoxyquinoline was demethylated and converted to corresponding AlIII complexes. Photophysical properties of two 4-aryl-Alq3 derivatives were then compared with properties of the parent Alq3 and a 5-phenyl-Alq3 congener. It appears that the 5-aryl derivatives show improved luminescence but also decreased physical stability. Electroluminescence of the prepared materials is presented and compared to Alq3 and a 5-phenyl-Alq3.

  16. Human erythrocytes and neuroblastoma cells are affected in vitro by Au(III) ions

    Energy Technology Data Exchange (ETDEWEB)

    Suwalsky, Mario, E-mail: msuwalsk@udec.cl [Faculty of Chemical Sciences, University of Concepcion, Casilla 160C, Concepcion (Chile); Gonzalez, Raquel [Faculty of Chemical Sciences, University of Concepcion, Casilla 160C, Concepcion (Chile); Villena, Fernando [Faculty of Biological Sciences, University of Concepcion, Concepcion (Chile); Aguilar, Luis F.; Sotomayor, Carlos P. [Instituto de Quimica, Universidad Catolica de Valparaiso, Valparaiso (Chile); Bolognin, Silvia; Zatta, Paolo [CNR Center on Metalloproteins, University of Padova, Padova (Italy)

    2010-06-25

    Gold compounds are well known for their neurological and nephrotoxic implications. However, haematological toxicity is one of the most serious toxic and less studied effects. The lack of information on these aspects of Au(III) prompted us to study the structural effects induced on cell membranes, particularly that of human erythrocytes. AuCl{sub 3} was incubated with intact erythrocytes, isolated unsealed human erythrocyte membranes (IUM) and molecular models of the erythrocyte membrane. The latter consisted of multibilayers of dimyristoylphosphatidylcholine and dimyristoylphosphatidylethanolamine, phospholipids classes located in the outer and inner monolayers of the human erythrocyte membrane, respectively. This report presents evidence that Au(III) interacts with red cell membranes as follows: (a) in scanning electron microscopy studies on human erythrocytes it was observed that Au(III) induced shape changes at a concentration as low as 0.01 {mu}M; (b) in isolated unsealed human erythrocyte membranes Au(III) induced a decrease in the molecular dynamics and/or water content at the glycerol backbone level of the lipid bilayer polar groups in a 5-50 {mu}M concentration range, and (c) X-ray diffraction studies showed that Au(III) in the 10 {mu}m-1 mM range induced increasing structural perturbation only to dimyristoylphosphatidylcholine bilayers. Additional experiments were performed in human neuroblastoma cells SH-SY5Y. A statistically significant decrease of cell viability was observed with Au(III) ranging from 0.1 {mu}M to 100 {mu}M.

  17. Human erythrocytes and neuroblastoma cells are affected in vitro by Au(III) ions

    International Nuclear Information System (INIS)

    Gold compounds are well known for their neurological and nephrotoxic implications. However, haematological toxicity is one of the most serious toxic and less studied effects. The lack of information on these aspects of Au(III) prompted us to study the structural effects induced on cell membranes, particularly that of human erythrocytes. AuCl3 was incubated with intact erythrocytes, isolated unsealed human erythrocyte membranes (IUM) and molecular models of the erythrocyte membrane. The latter consisted of multibilayers of dimyristoylphosphatidylcholine and dimyristoylphosphatidylethanolamine, phospholipids classes located in the outer and inner monolayers of the human erythrocyte membrane, respectively. This report presents evidence that Au(III) interacts with red cell membranes as follows: (a) in scanning electron microscopy studies on human erythrocytes it was observed that Au(III) induced shape changes at a concentration as low as 0.01 μM; (b) in isolated unsealed human erythrocyte membranes Au(III) induced a decrease in the molecular dynamics and/or water content at the glycerol backbone level of the lipid bilayer polar groups in a 5-50 μM concentration range, and (c) X-ray diffraction studies showed that Au(III) in the 10 μm-1 mM range induced increasing structural perturbation only to dimyristoylphosphatidylcholine bilayers. Additional experiments were performed in human neuroblastoma cells SH-SY5Y. A statistically significant decrease of cell viability was observed with Au(III) ranging from 0.1 μM to 100 μM.

  18. Interaction of antithrombin III with preadsorbed albumin-heparin conjugates

    OpenAIRE

    Hennink, W.E.; Ebert, C.D.; Kim, S. W.; Breemhaar, W.; Bantjes, A.; Feijen, J.

    1984-01-01

    The adsorption of antithrombin III (AT III) onto polystyrene surfaces preadsorbed with albumin or albuminheparin conjugates was studied using a two step enzyme immuno assay. When AT III-buffer solutions were used, the highest adsorption values were measured on high affinity albumin-heparin conjugate pretreated surfaces. Less AT III adsorption was found on nonfractionated albumin-heparin conjugate preadsorbed surfaces. AT III adsorption could also be detected on low affinity conjugate and albu...

  19. Fluorescence of lanthanide(III) complexes in aqueous solutions

    International Nuclear Information System (INIS)

    The fluorescence of lanthanide ions and of their complexes with EDTA, NTA and AA in aqueous solutions was investigated. It has been shown that the fluorescence band intensities of Sm(III), Eu(III), Gd(III), Tb(III) and Dy(III) complexes depend on the pH and the complexing agent concentration. Fluorescence measurements were used to characterise the lanthanide complexes formed and an attempt was made to interpret the results theoretically. (Author)

  20. Luminescence studies of Sm(III) and Cm(III) complexes in NaSCN/DHDECMP extraction systems

    CERN Document Server

    Chung, D Y; Kimura, T

    1999-01-01

    Laser-induced fluorescence (LIF) studies of Sm(III) and Cm(III) complexes in the NaSCN/DHDECMP solvent extraction system were carried out. Luminescence lifetimes were measured to determine the number of water molecules coordinated to Sm(III), Tb(III), Dy(III), and Cm(III) in the sodium thiocyanate solution and in the DHDECMP phase. The hydration number of Sm(III), Tb(III), Dy(III), and Cm(III) in the sodium thiocyanate solution decreased linearly with increasing sodium thiocyanate concentration. The hydration numbers of Sm(III), Dy(III), and Cm(III) in the DHDECMP phase decreased with increasing sodium thiocyanate concentration. The water molecules in the inner coordination sphere of Sm(III) and Dy(III) extracted into the DHDECMP were not completely removed at low sodium thiocyanate concentration but decreased with increasing sodium thiocyanate concentration. However, in the case of Cm(III) extracted into the DHDECMP phase from the sodium thiocyanate solution, there was no water in the inner coordination sphe...