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Sample records for cjd vcjd questions

  1. Variant Creutzfeldt-Jakob Disease (vCJD)

    Science.gov (United States)

    ... disease in cows, bovine spongiform encephalopathy (BSE or 'mad cow' disease), is the same agent responsible for the outbreak ... US Clinical and Pathologic Characteristics Relationship with BSE (Mad Cow Disease) Surveillance for vCJD Resources News and Highlights Updated: ...

  2. vCJD risk in the Republic of Ireland.

    LENUS (Irish Health Repository)

    Harney, Michael S

    2003-11-26

    BACKGROUND: The Republic of Ireland has the second highest incidence of BSE worldwide. Only a single case of vCJD has been identified to date. METHODS: We estimate the total future number of clinical cases of vCJD using an established mathematical model, and based on infectivity of bovine tissue calculated from UK data and on the relative exposure to BSE contaminated meat. RESULTS: We estimate 1 future clinical case (95% CI 0-15) of vCJD in the Republic of Ireland. Irish exposure is from BSE infected indigenous beef products and from imported UK beef products. Additionally, 2.5% of the Irish population was exposed to UK beef through residing in the UK during the \\'at-risk\\' period. The relative proportion of risk attributable to each of these three exposures individually is 2:2:1 respectively. CONCLUSIONS: The low numbers of future vCJD cases estimated in this study is reassuring for the Irish population and for other countries with a similar level of BSE exposure.

  3. vCJD prion acquires altered virulence through trans-species infection.

    Science.gov (United States)

    Asano, Masahiro; Mohri, Shirou; Ironside, James W; Ito, Mamoru; Tamaoki, Norikazu; Kitamoto, Tetsuyuki

    2006-03-31

    Variant Creutzfeldt-Jakob disease (vCJD) appears to be caused by infection with the bovine spongiform encephalopathy (BSE) agent. To date, all patients with vCJD are homozygous for methionine at codon 129 of the PrP gene. To investigate the relationship between polymorphism at codon 129 and susceptibility to BSE or vCJD prions, we performed splenic follicular dendritic cell assay with humanized knock-in mice through peripheral infection. All humanized knock-in mice showed little or no susceptibility to BSE prions. Only the subset of humanized knock-in mice with codon 129 Met/Met genotype showed weak susceptibility by Western blotting. Surprisingly, we succeeded in the transmission of vCJD prions to humanized knock-in mice not only with codon 129 Met/Met but also with codon 129 Met/Val. Humanized knock-in mice with codon 129 Val/Val were not susceptible. The results suggest that human heterozygotes at codon 129 are also at risk for secondary infection with vCJD. PMID:16480953

  4. Impacts and concerns for vCJD in blood transfusion: current status.

    Science.gov (United States)

    MacGregor, I R; Prowse, C V

    2004-06-01

    The impact of vCJD upon blood transfusion practice hinges on its lymphoreticular involvement. B lymphocytes play a key supporting role for the capture and replication of infectivity by follicular dendritic cells of the lymphoid tissue in animal models of transmissible spongiform encephalopathies (TSE) and tonsils, spleen and appendix in man can harbour vCJD infectivity, a situation not seen with the other human TSEs. Leucodepletion of blood donations in the UK was implemented to reduce possible vCJD transmission and preliminary data suggests that white cell associated infectivity will be effectively removed although plasma infectivity will not. Blood screening assays are under development but none yet are ready for application. The conformation dependant immunoassay, based on differences in secondary and tertiary structure between normal and TSE-associated abnormal prion protein, has a sensitivity now approaching the best bioassay. Even so further development is needed to detect the fg/ml levels likely in the event that vCJD blood does contain abnormal prion, which is as yet unproven. Surrogate assays, such as for erythroid associated factor, may provide additional means of identifying donors harbouring vCJD. Validation of clearance of TSEs from pooled plasma products consistently demonstrates effective removal of the agents in downscaled systems and studies comparing vCJD, BSE and scrapie agents yield similar results. Many approaches to therapy are under investigation, in cell culture and animal models, targeted to normal or abnormal prion metabolism, including chemical and immunological interventions. Efficacy of quinacrine/chlorpromazine and pentosan polysulphate in a clinical setting, and agents yet to be used, will be more accurately known following recent agreement of clinical drug evaluation protocols. PMID:15354867

  5. No evidence of asymptomatic variant CJD infection in immunodeficiency patients treated with UK-sourced immunoglobulin.

    Science.gov (United States)

    Helbert, M R; Bangs, C; Bishop, M; Molesworth, A; Ironside, J

    2016-04-01

    Surveillance of 75 immunodeficiency patients exposed to UK-sourced immunoglobulin, including batches derived from donors who went on to develop vCJD, has not detected any clinical cases of vCJD, or of asymptomatic infection in 15 patients with available tissue samples of sufficient quality for testing. PMID:26529032

  6. Application of Atomic Dielectric Resonance Spectroscopy for the screening of blood samples from patients with clinical variant and sporadic CJD

    Directory of Open Access Journals (Sweden)

    Ironside James W

    2007-08-01

    Full Text Available Abstract Background Sub-clinical variant Creutzfeldt-Jakob disease (vCJD infection and reports of vCJD transmission through blood transfusion emphasise the need for blood screening assays to ensure the safety of blood and transplanted tissues. Most assays aim to detect abnormal prion protein (PrPSc, although achieving required sensitivity is a challenge. Methods We have used innovative Atomic Dielectric Resonance Spectroscopy (ADRS, which determines dielectric properties of materials which are established by reflectivity and penetration of radio/micro waves, to analyse blood samples from patients and controls to identify characteristic ADR signatures unique to blood from vCJD and to sCJD patients. Initial sets of blood samples from vCJD, sCJD, non-CJD neurological diseases and normal healthy adults (blood donors were screened as training samples to determine group-specific ADR characteristics, and provided a basis for classification of blinded sets of samples. Results Blood sample groups from vCJD, sCJD, non-CJD neurological diseases and normal healthy adults (blood donors screened by ADRS were classified with 100% specificity and sensitivity, discriminating these by a co-variance expert analysis system. Conclusion ADRS appears capable of recognising and discriminating serum samples from vCJD, sCJD, non-CJD neurological diseases, and normal healthy adults, and might be developed to provide a system for primary screening or confirmatory assay complementary to other screening systems.

  7. SPONGIFORM DISEASE: Experts Downplay New vCJD Fears.

    Science.gov (United States)

    Balter, M

    2000-09-01

    The chilling scenario of getting "mad cow disease" from eating products of other animals besides just cows was splashed across the mainstream British press last week based on a report from a leading U.K. lab that prions--abnormal proteins linked to bovine spongiform encephalopathy and its human form, variant Creutzfeldt-Jakob disease--can jump from one species to another more easily than previously believed. Although some experts say the findings raise concern about a threat to human health, others decry the media frenzy and contend that the new research adds little to what is known about the mysterious, fatal diseases. PMID:17811144

  8. Multiorgan detection and characterization of protease-resistant prion protein in a case of variant CJD examined in the United States.

    Directory of Open Access Journals (Sweden)

    Silvio Notari

    Full Text Available BACKGROUND: Variant Creutzfeldt-Jakob disease (vCJD is a prion disease thought to be acquired by the consumption of prion-contaminated beef products. To date, over 200 cases have been identified around the world, but mainly in the United Kingdom. Three cases have been identified in the United States; however, these subjects were likely exposed to prion infection elsewhere. Here we report on the first of these subjects. METHODOLOGY/PRINCIPAL FINDINGS: Neuropathological and genetic examinations were carried out using standard procedures. We assessed the presence and characteristics of protease-resistant prion protein (PrP(res in brain and 23 other organs and tissues using immunoblots performed directly on total homogenate or following sodium phosphotungstate precipitation to increase PrP(res detectability. The brain showed a lack of typical spongiform degeneration and had large plaques, likely stemming from the extensive neuronal loss caused by the long duration (32 months of the disease. The PrP(res found in the brain had the typical characteristics of the PrP(res present in vCJD. In addition to the brain and other organs known to be prion positive in vCJD, such as the lymphoreticular system, pituitary and adrenal glands, and gastrointestinal tract, PrP(res was also detected for the first time in the dura mater, liver, pancreas, kidney, ovary, uterus, and skin. CONCLUSIONS/SIGNIFICANCE: Our results indicate that the number of organs affected in vCJD is greater than previously realized and further underscore the risk of iatrogenic transmission in vCJD.

  9. An unusual case of sporadic Creutzfeldt-Jakob disease (CJD).

    Science.gov (United States)

    Javed, Qaiser; Alam, Faouzi; Krishna, Sowmya; Jaganathan, Geetha

    2010-01-01

    A 49-year-old healthy white British female, not previously known to psychiatric services, presented with an acute onset of florid psychotic symptoms. Her symptoms included visual, auditory and tactile hallucinations as well as persecutory delusions. She was started on antipsychotic medication; however, her psychotic symptoms did not improve significantly in the first 3 months. Her blood tests were normal. Lumbar puncture was performed which was positive for protein 14-3-3. A computed tomography scan of the brain showed generalised atrophic changes. The history of early visual hallucinations, rapid cognitive decline and positive 14-3-3 result was in keeping with the Heidenhain variant of sporadic Creutzfeldt-Jakob disease (sCJD). Despite a short life expectancy as reported in literature, our patient, who was diagnosed with sCJD more than two-and-a-half years ago, is still alive. We therefore believe this is an important finding to report.

  10. CJD, Progress Report, 2010/2011, Summary of nuclear data activity by staff of the IPPE CJD

    International Nuclear Information System (INIS)

    Since last NRDC-2011 meeting the compilation in the EXFOR and the work on fulfillment of meeting's Conclusions and Actions have been done in the center. But substantial part of CJD activity was related to the nuclear data evaluation. 1) Staff 2) EXFOR activity 3) NRDC2011 actions 4) Computer and software matters. WEB-site service 5) Nuclear data evaluation activity 6) Nuclear Data services 7) Journal YK 8) Publications 9) Acknowledgments

  11. High CJD infectivity remains after prion protein is destroyed.

    Science.gov (United States)

    Miyazawa, Kohtaro; Emmerling, Kaitlin; Manuelidis, Laura

    2011-12-01

    The hypothesis that host prion protein (PrP) converts into an infectious prion form rests on the observation that infectivity progressively decreases in direct proportion to the decrease of PrP with proteinase K (PK) treatment. PrP that resists limited PK digestion (PrP-res, PrP(sc)) has been assumed to be the infectious form, with speculative types of misfolding encoding the many unique transmissible spongiform encephalopathy (TSE) agent strains. Recently, a PK sensitive form of PrP has been proposed as the prion. Thus we re-evaluated total PrP (sensitive and resistant) and used a cell-based assay for titration of infectious particles. A keratinase (NAP) known to effectively digest PrP was compared to PK. Total PrP in FU-CJD infected brain was reduced to ≤0.3% in a 2 h PK digest, yet there was no reduction in titer. Remaining non-PrP proteins were easily visualized with colloidal gold in this highly infectious homogenate. In contrast to PK, NAP digestion left 0.8% residual PrP after 2 h, yet decreased titer by >2.5 log; few residual protein bands remained. FU-CJD infected cells with 10× the infectivity of brain by both animal and cell culture assays were also evaluated. NAP again significantly reduced cell infectivity (>3.5 log). Extreme PK digestions were needed to reduce cell PrP to report on maximal PrP destruction and titer. It is likely that one or more residual non-PrP proteins may protect agent nucleic acids in infectious particles.

  12. CJD [Russian Nuclear Data Center]: Progress report 2005/06

    International Nuclear Information System (INIS)

    Nominally the CINDA activity is continued. All types of publications (Russian scientific journals, preprints and so on) are investigated to include in CINDA compilation. We are going to adopt the new technology process created by the NDS and NEA DB for a CINDA compilation and to start in a participation of exchange of CINDA compilation. During 2005-2006 the three issues of the journal 'Yadernye Konstanty' were prepared and printed. The nuclear data services are provided through direct contact with the users from many Russian organizations. Mainly the compilation of the evaluated data of the different types are needed. The new data library ACDAM for the activation/damage calculations is compiled in the Russian Nuclear Data Center. A new version of the Russian Reactor Dosimetry File is prepared and now it is under the compilation and benchmark testing. Evaluated data files were made for the 26 reactions with the covariance matrices. Some of them were included into the IRDF-2002 compiled by the NDS. New evaluated data sets were prepared in during 2006. CJD was engaged in re-evaluation and preparation of evaluated neutron data for minor actinides and fission products for the FOND Library which is a base for the ABBN group constant system. The correction, processing and testing of modified evaluated data files is under way

  13. Application of quantitative DTI metrics in sporadic CJD

    Directory of Open Access Journals (Sweden)

    E. Caverzasi

    2014-01-01

    Full Text Available Diffusion Weighted Imaging is extremely important for the diagnosis of probable sporadic Jakob–Creutzfeldt disease, the most common human prion disease. Although visual assessment of DWI MRI is critical diagnostically, a more objective, quantifiable approach might more precisely identify the precise pattern of brain involvement. Furthermore, a quantitative, systematic tracking of MRI changes occurring over time might provide insights regarding the underlying histopathological mechanisms of human prion disease and provide information useful for clinical trials. The purposes of this study were: 1 to describe quantitatively the average cross-sectional pattern of reduced mean diffusivity, fractional anisotropy, atrophy and T1 relaxation in the gray matter (GM in sporadic Jakob–Creutzfeldt disease, 2 to study changes in mean diffusivity and atrophy over time and 3 to explore their relationship with clinical scales. Twenty-six sporadic Jakob–Creutzfeldt disease and nine control subjects had MRIs on the same scanner; seven sCJD subjects had a second scan after approximately two months. Cortical and subcortical gray matter regions were parcellated with Freesurfer. Average cortical thickness (or subcortical volume, T1-relaxiation and mean diffusivity from co-registered diffusion maps were calculated in each region for each subject. Quantitatively on cross-sectional analysis, certain brain regions were preferentially affected by reduced mean diffusivity (parietal, temporal lobes, posterior cingulate, thalamus and deep nuclei, but with relative sparing of the frontal and occipital lobes. Serial imaging, surprisingly showed that mean diffusivity did not have a linear or unidirectional reduction over time, but tended to decrease initially and then reverse and increase towards normalization. Furthermore, there was a strong correlation between worsening of patient clinical function (based on modified Barthel score and increasing mean diffusivity.

  14. RARB and STMN2 polymorphisms are not associated with sporadic Creutzfeldt-Jakob disease (CJD) in the Korean population.

    Science.gov (United States)

    Jeong, Byung-Hoon; Kim, Hae-Jung; Lee, Kyung-Hee; Carp, Richard I; Kim, Yong-Sun

    2014-01-01

    Polymorphisms in the prion protein gene (PRNP) can affect the susceptibility of humans to prion diseases. Recently, aside from PRNP, single nucleotide polymorphisms (SNPs) of two candidate genes for susceptibility to human prion diseases have been identified by human genome-wide association studies (GWAS) in the British population. One SNP of retinoic acid receptor beta (RARB), which is correlated with prion disease incubation time in mice, was associated with human prion diseases such as variant and iatrogenic CJD in the British population. The other SNP of the gene that encodes SCG10 (STMN2), which is related to clinical onset of sporadic CJD, was also associated with variant CJD and kuru. In order to investigate whether two polymorphisms located in upstream of RARB and STMN2 are associated with sporadic CJD in the Korean population, we compared genotype and allele frequencies of these polymorphisms in 217 sporadic CJD patients and 216 healthy Koreans. The genotype distribution and allele frequencies in upstream of the RARB and STMN2 polymorphisms were not significantly different between healthy controls and Korean sporadic CJD patients. This finding indicates that the two SNPs are not correlated with genetic susceptibility to sporadic CJD in the Korean population. This is the first genetic association study of RARB and STMN2 with sporadic CJD in an Asian population.

  15. Novel mutation of the PRNP gene of a clinical CJD case

    Directory of Open Access Journals (Sweden)

    Collinge John

    2006-11-01

    Full Text Available Abstract Background Transmissible spongiform encephalopathies (TSEs, a group of neurodegenerative diseases, are thought to be caused by an abnormal isoform of a naturally occurring protein known as cellular prion protein, PrPC. The abnormal form of prion protein, PrPSc accumulates in the brain of affected individuals. Both isoforms are encoded by the same prion protein gene (PRNP, and the structural changes occur post-translationally. Certain mutations in the PRNP gene result in genetic TSEs or increased susceptibility to TSEs. Case presentation A 70 year old woman was admitted to the hospital with severe confusion and inability to walk. Relatives recognized memory loss, gait and behavioral disturbances over a six month period prior to hospitalization. Neurological examination revealed Creutzfeldt-Jakob disease (CJD related symptoms such as incontinence, Babinski sign and myoclonus. EEG showed periodic sharp waves typical of sporadic CJD and cerebrospinal fluid analysis (CSF was positive for the presence of the 14-3-3-protein. As the disease progressed the patient developed akinetic mutism and died in the tenth month after onset of the disease symptoms. Unfortunately, no autopsy material was available. PRNP sequencing showed the occurrence of a point mutation on one allele at codon 193, which is altered from ACC, coding for a threonine, to ATC, encoding an isoleucine (T193I. Conclusion Here we report a novel mutation of the PRNP gene found in an elderly female patient resulting in heterozygosity for isoleucine and threonine at codon 193, in which normally homozygosity for threonine is expected (T193. The patient presented typical clinical symptoms of CJD. EEG findings and the presence of the 14-3-3 protein in the CSF, contributed to CJD diagnosis, allowing the classification of this case as a probable CJD according to the World Health Organization (WHO accepted criteria.

  16. Decreased CSF transferrin in sCJD: a potential pre-mortem diagnostic test for prion disorders.

    Directory of Open Access Journals (Sweden)

    Ajay Singh

    Full Text Available Sporadic Creutzfeldt-Jakob-disease (sCJD is a fatal neurodegenerative condition that escapes detection until autopsy. Recently, brain iron dyshomeostasis accompanied by increased transferrin (Tf was reported in sCJD cases. The consequence of this abnormality on cerebrospinal-fluid (CSF levels of Tf is uncertain. We evaluated the accuracy of CSF Tf, a 'new' biomarker, as a pre-mortem diagnostic test for sCJD when used alone or in combination with the 'current' biomarker total-tau (T-tau. Levels of total-Tf (T-Tf, isoforms of Tf (Tf-1 and Tf-β2, and iron saturation of Tf were quantified in CSF collected 0.3-36 months before death (duration from 99 autopsy confirmed sCJD (CJD+ and 75 confirmed cases of dementia of non-CJD origin (CJD-. Diagnostic accuracy was estimated by non-parametric tests, logistic regression, and receiver operating characteristic (ROC analysis. Area under the ROC curve (AUC, sensitivity, specificity, positive and negative predictive values (PV, and likelihood ratios (LR of each biomarker and biomarker combination were calculated. We report that relative to CJD-, CJD+ cases had lower median CSF T-Tf (125,7093 vs. 217,7893 and higher T-tau (11530 vs. 1266 values. AUC was 0.90 (95% confidence interval (CI, 0.85-0.94 for T-Tf, and 0.93 (95% CI, 0.89-0.97 for T-Tf combined with T-tau. With cut-offs defined to achieve a sensitivity of ∼85%, T-Tf identified CJD+ cases with a specificity of 71.6% (95% CI, 59.1-81.7, positive LR of 3.0 (95% CI, 2.1-4.5, negative LR of 0.2 (95% CI, 0.1-0.3, and accuracy of 80.1%. The effect of patient age and duration was insignificant. T-Tf combined with T-tau identified CJD+ with improved specificity of 87.5% (95%CI, 76.3-94.1, positive LR of 6.8 (95% CI, 3.5-13.1, negative LR of 0.2 (95% CI, 0.1-0.3, positive-PV of 91.0%, negative-PV of 80.0%, and accuracy of 86.2%. Thus, CSF T-Tf, a new biomarker, when combined with the current biomarker T-tau, is a reliable pre-mortem diagnostic test for sCJD.

  17. Risk for Travelers

    Science.gov (United States)

    ... Cow Disease Chronic Wasting Disease (CWD) Prion Diseases Risk for Travelers Recommend on Facebook Tweet Share Compartir ... Jakob Disease (vCJD) by Blood and Blood Products . Risk for Travelers The current risk of acquiring vCJD ...

  18. Mutation and polymorphism of the prion protein gene in Libyan Jews with Creutzfeldt-Jakob disease (CJD)

    Energy Technology Data Exchange (ETDEWEB)

    Gabizon, R.; Rosenmann, H.; Meiner, Z.; Kahana, I. (Hadassah Univ., Jerusalem (Israel)); Kahana, E. (Barzilai Medical Center, Ashkelon (Israel)); Shugart, Y.; Ott, J. (Columbia Univ., New York, NY (United States)); Prusiner, S.B. (Univ. of California, San Francisco, CA (United States))

    1993-10-01

    The inherited prion diseases are neurodegenerative disorders which are not only genetic but also transmissible. More than a dozen mutations in the prion protein gene that result in nonconservative amino acid substitutions segregate with the inherited prion diseases including familial Creutzfeldt-Jakob disease (CJD). In Israel, the incidence of CJD is about 1 case/10[sup 4] Libyan Jews. A Lys[sub 200] substitution segregates with CJD and is reported here to be genetically linked to CJD with a lod score of >4.8. Some healthy elderly Lys[sub 200] carriers > age 65 years were identified, suggesting the possibility of incomplete penetrance. In contrast, no linkage was found between the development of familial CJD and a polymorphism encoding either Met[sub 129] or Val[sub 129]. All Libyan Jewish CJD patients with the Lys[sub 200] mutation encode a Met[sub 129] on the mutant allele. Homozygosity for Met[sub 129] did not correlate with age at disease onset or the duration of illness. The frequency of the Met[sub 129] allele was higher in the affected pedigrees than in a control population of Libyan Jews. The frequency of the Met[sub 129] and Val[sub 129] alleles in the control Libyan population was similar to that found in the general Caucasian population. The identification of three Libyan Jews homozygous for the Lys[sub 200] mutation suggests frequent intrafamilial marriages, a custom documented by genealogical investigations. 26 refs., 3 figs., 6 tabs.

  19. CJD and Scrapie Require Agent-Associated Nucleic Acids for Infection.

    Science.gov (United States)

    Botsios, Sotirios; Manuelidis, Laura

    2016-08-01

    Unlike Alzheimer's and most other neurodegenerative diseases, Transmissible Spongiform Encephalopathies (TSEs) are all caused by actively replicating infectious particles of viral size and density. Different strain-specific TSE agents cause CJD, kuru, scrapie and BSE, and all behave as latent viruses that evade adaptive immune responses and can persist for years in lymphoreticular tissues. A foreign viral structure with a nucleic acid genome best explains these TSE strains and their endemic and epidemic spread in susceptible species. Nevertheless, it is widely believed that host prion protein (PrP), without any genetic material, encodes all these strains. We developed rapid infectivity assays that allowed us to reproducibly isolate infectious particles where >85% of the starting titer separated from the majority of host components, including PrP. Remarkably, digestion of all forms of PrP did not reduce brain particle titers. To ask if TSE agents, as other viruses, require nucleic acids, we exposed high titer FU-CJD and 22L scrapie particles to potent nucleases. Both agent-strains were propagated in GT1 neuronal cells to avoid interference by complex degenerative brain changes that can impede nuclease digestions. After exposure to nucleases that are active in sarkosyl, infectivity of both agents was reproducibly reduced by ≥99%. No gold-stained host proteins or any form of PrP were visibly altered by these nucleases. In contrast, co-purifying protected mitochondrial DNA and circular SPHINX DNAs were destroyed. These findings demonstrate that TSE agents require protected genetic material to infect their hosts, and should reopen investigation of essential agent nucleic acids. J. Cell. Biochem. 117: 1947-1958, 2016. © 2016 Wiley Periodicals, Inc. PMID:26773845

  20. R3-R4 deletion in the PRNP gene is associated with Creutzfeldt-Jakob disease (CJD)

    Energy Technology Data Exchange (ETDEWEB)

    Cervenakova, L.; Brown, P.; Nagle, J. [and others

    1994-09-01

    There are conflicting reports on the association of deletions in the PRNP gene on chromosome 20 with CJD, a rapidly progressive fatal spongiform encephalopathy. We accumulated data suggesting that a deletion of R3-R4 type (parts of the third and fourth repeats are deleted from the area of four repeating 24 bp sequences in the 5{prime} region of the gene) is causing CJD. Screening of 129 unaffected control individuals demonstrated presence of a deletion of R2 type in four (1.55% of the studied chromosomes), but none of them had the R3-R4 type. Of 181 screened patients with spongiform encephalopathies, two had a deletion of R3-R4 type with no other mutations in the coding sequence. Both patients had a classical rapidly progressive dementing disease and diffuse spongiform degeneration, and both cases were apparently sporadic. The same R3-R4 type of deletion was detected in three additional neuropathologically confirmed spongiform encephalopathy patients, of which two had other known pathogenic mutations in the PRNP gene: at codon 178 on the methionine allele exhibiting the phenotype of fatal familial insomnia, and codon 200 causing CJD with severe dementia; the third was a patient with iatrogenic CJD who developed the disease after treatment with growth hormone extracted from cadaveric human pituitary glands. In all cases the deletion coincided with a variant sequence at position 129 coding for methionine.

  1. Factors that influence the age distribution of BSE cases: potentials for age targeting in surveillance

    NARCIS (Netherlands)

    Koeijer, de A.; Schreuder, B.; Bouma, A.

    2002-01-01

    Recently, due to consumers fears concerning BSE and vCJD, the need arose for methods to detect BSE, to estimate the present prevalence of BSE among cattle and to predict future BSE prevalence. As a part of that set of urgent questions, it has become important to indicate groups in which BSE risk is

  2. Mad Cows and CJD A Physicist's View of Prion Brain Diseases

    CERN Document Server

    Morrison, Douglas Robert Ogston

    1997-01-01

    The research of Carleton Gajdusek on a stone-age tribe in Papua New Guinea, who suffered from a mysterious disease, kuru, spread by cannibalism, is described and short extracts from his films will be shown. Some deaths from kuru are still occuring after 45 years. This disease is believed to be caused by an entirely new mechanism, not a virus or bacteria, but by a small molecule known as a prion that occurs naturally in many living forms. The Prion Only hypothesis of Stan Prusiner is discussed critically. It has been calculated that 900,000 cows in Britain had the Mad Cow disease, BSE, but most were slaughtered before symptoms were recognised. This epidemic started with 10 cases in the first year, and finally 160,000 were officially classified as having BSE; it is now slowly dying out. The human epidemic, caused by a new version of Creutzfeldt-Jakob Disease, nvCJD, affects mainly young people, has just begun with 10 cases in the first year. The average incubation time may be about 14 years then death follows i...

  3. Impact of the clinical context on the 14-3-3 test for the diagnosis of sporadic CJD

    Directory of Open Access Journals (Sweden)

    Sierra-Moros Maríajosé

    2006-07-01

    Full Text Available Abstract Background The 14-3-3 test appears to be a valuable aid for the clinical diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD in selected populations. However, its usefulness in routine practice has been challenged. In this study, the influence of the clinical context on the performance of the 14-3-3 test for the diagnosis of sCJD is investigated through the analysis of a large prospective clinical series. Methods Six hundred seventy-two Spanish patients with clinically suspected sCJD were analyzed. Clinical classification at sample reception according to the World Health Organization's (WHO criteria (excluding the 14-3-3 test result was used to explore the influence of the clinical context on the pre-test probabilities, and positive (PPV and negative (NPV predictive values of the 14-3-3 test. Results Predictive values of the test varied greatly according to the initial clinical classification: PPV of 98.8%, 96.5% and 45.0%, and NPV of 26.1%, 66.6% and 100% for probable sCJDi (n = 115, possible sCJDi (n = 73 and non-sCJDi (n = 484 cases, respectively. According to multivariate and Bayesian analyses, these values represent an improvement of diagnostic certainty compared to clinical data alone. Conclusion In three different contexts of sCJD suspicion, the 14-3-3 assay provides useful information complementary to clinical and electroencephalographic (EEG data. The test is most useful supporting a clinical impression, whilst it may show deceptive when it is not in agreement with clinical data.

  4. Long term survival in a patient with variant Creutzfeldt–Jakob disease treated with intraventricular pentosan polysulphate

    OpenAIRE

    Parry, A.; Baker, I; Stacey, R.; Wimalaratna, S

    2007-01-01

    Variant Creutzfeldt‐Jakob disease (vCJD) is a neurodegenerative disease that principally affects young people and has a median duration of illness of 13 (range 6–39) months. vCJD is incurable and there are currently no treatments that conclusively slow the rate of disease progression. However, recent animal studies and isolated case reports have suggested that treatment with intraventricular pentosan polysulphate (PPS) may be beneficial in the treatment of patients with vCJD.

  5. Questioning Techniques.

    Science.gov (United States)

    Patterson, Michelle

    1999-01-01

    Questions are so much a part of the classroom routine and they should stimulate learning and thinking. Introduces the Questioning and Understanding to Improve Learning and Thinking (QUILT) method which incorporates Bloom's Taxonomy and wait time. (ASK)

  6. Atypical sporadic CJD-MM phenotype with white matter kuru plaques associated with intranuclear inclusion body and argyrophilic grain disease.

    Science.gov (United States)

    Berghoff, Anna S; Trummert, Anita; Unterberger, Ursula; Ströbel, Thomas; Hortobágyi, Tibor; Kovacs, Gabor G

    2015-08-01

    We describe an atypical neuropathological phenotype of sporadic Creutzfeldt-Jakob disease in a 76-year-old man. The clinical symptoms were characterized by progressive dementia, gait ataxia, rigidity and urinary incontinence. The disease duration was 6 weeks. MRI did not show prominent atrophy or hyperintensities in cortical areas, striatum or thalamus. Biomarker examination of the cerebrospinal fluid deviated from that seen in pure Alzheimer's disease. Triphasic waves in the EEG were detected only later in the disease course, while 14-3-3 assay was positive. PRNP genotyping revealed methionine homozygosity (MM) at codon 129. Neuropathology showed classical CJD changes corresponding to the MM type 1 cases. However, a striking feature was the presence of abundant kuru-type plaques in the white matter. This rare morphology was associated with neuropathological signs of intranuclear inclusion body disease and advanced stage of argyrophilic grain disease. These alterations did not show correlation with each other, thus seemed to develop independently. This case further highlights the complexity of neuropathological alterations in the ageing brain.

  7. Atypical sporadic CJD-MM phenotype with white matter kuru plaques associated with intranuclear inclusion body and argyrophilic grain disease.

    Science.gov (United States)

    Berghoff, Anna S; Trummert, Anita; Unterberger, Ursula; Ströbel, Thomas; Hortobágyi, Tibor; Kovacs, Gabor G

    2015-08-01

    We describe an atypical neuropathological phenotype of sporadic Creutzfeldt-Jakob disease in a 76-year-old man. The clinical symptoms were characterized by progressive dementia, gait ataxia, rigidity and urinary incontinence. The disease duration was 6 weeks. MRI did not show prominent atrophy or hyperintensities in cortical areas, striatum or thalamus. Biomarker examination of the cerebrospinal fluid deviated from that seen in pure Alzheimer's disease. Triphasic waves in the EEG were detected only later in the disease course, while 14-3-3 assay was positive. PRNP genotyping revealed methionine homozygosity (MM) at codon 129. Neuropathology showed classical CJD changes corresponding to the MM type 1 cases. However, a striking feature was the presence of abundant kuru-type plaques in the white matter. This rare morphology was associated with neuropathological signs of intranuclear inclusion body disease and advanced stage of argyrophilic grain disease. These alterations did not show correlation with each other, thus seemed to develop independently. This case further highlights the complexity of neuropathological alterations in the ageing brain. PMID:25783686

  8. The first report of RPSA polymorphisms, also called 37/67 kDa LRP/LR gene, in sporadic Creutzfeldt-Jakob disease (CJD

    Directory of Open Access Journals (Sweden)

    Jeong Byung-Hoon

    2011-08-01

    Full Text Available Abstract Background Although polymorphisms of PRNP, the gene encoding prion protein, are known as a determinant affecting prion disease susceptibility, other genes also influence prion incubation time. This finding offers the opportunity to identify other genetic or environmental factor (s modulating susceptibility to prion disease. Ribosomal protein SA (RPSA, also called 37 kDa laminin receptor precursor (LRP/67 kDa laminin receptor (LR, acts as a receptor for laminin, viruses and prion proteins. The binding/internalization of prion protein is dependent for LRP/LR. Methods To identify other susceptibility genes involved in prion disease, we performed genetic analysis of RPSA. For this case-control study, we included 180 sporadic Creutzfeldt-Jakob disease (CJD patients and 189 healthy Koreans. We investigated genotype and allele frequencies of polymorphism on RPSA by direct sequencing or restriction fragment length polymorphism (RFLP analysis. Results We observed four single nucleotide polymorphisms (SNPs, including -8T>C (rs1803893 in the 5'-untranslated region (UTR of exon 2, 134-32C>T (rs3772138 in the intron, 519G>A (rs2269350 in the intron and 793+58C>T (rs2723 in the intron on the RPSA. The 519G>A (at codon 173 is located in the direct PrP binding site. The genotypes and allele frequencies of the RPSA polymorphisms showed no significant differences between the controls and sporadic CJD patients. Conclusion These results suggest that these RPSA polymorphisms have no direct influence on the susceptibility to sporadic CJD. This was the first genetic association study of the polymorphisms of RPSA gene with sporadic CJD.

  9. The M129V polymorphism of codon 129 in the prion gene (PRNP) in the Danish population

    DEFF Research Database (Denmark)

    Dyrbye, Henrik; Broholm, Helle; Dziegiel, Morten Hanefeld;

    2008-01-01

    probability and phenotype. Importantly, two common variants of codon 129 in PRNP code for methionine (Met) or valine (Val), respectively. All hitherto known cases of vCJD have been Met/Met homozygotes. The aim of this study was to investigate the susceptibility to vCJD in the Danish population by determining...

  10. Variant Creutzfeldt-Jakob disease

    NARCIS (Netherlands)

    E.A. Croes (Esther); C.M. van Duijn (Cock)

    2003-01-01

    textabstractA variant form of Creutzfeldt-Jakob disease (vCJD) has had major impact in Europe during the last decade. In this article, we review the aetiology of vCJD and its relation with bovine spongiform encephalopathy. Further, treatment of the disease, the strategies focusing on prevention of t

  11. Phase I/II safety study of transfusion of prion-filtered red cell concentrates in transfusion-dependent patients.

    LENUS (Irish Health Repository)

    Cahill, M R

    2010-08-01

    Variant Creutzfeldt-Jakob (vCJD) is a fatal transfusion transmissible prion infection. No test for vCJD in the donor population is currently available. Therefore, prion removal by filtration of red cell concentrate (RCC) is an attractive option for prevention.

  12. The human prion diseases. A review with special emphasis on new variant CJD and comments on surveillance.

    LENUS (Irish Health Repository)

    Keohane, C

    2012-02-03

    The transmissible spongiform encephalopathies or prion diseases represent a new group of diseases with unique clinical and neuropathological features, the transmission of which is both genetic and infectious. The responsible agent is unconventional and appears to be largely composed of a glycoprotein, the prion protein PrP. This is normally present on different cells. In prion diseases, it becomes converted to the pathogenic form PrPres which is resistant to proteinase and accumulates within the brain and this process is accompanied by the development of spongiform change, gliosis and neuronal loss. The human prion diseases include Kuru a progressive cerebellar degeneration with late dementia affecting Fore tribes in New-Guinea, now almost extinct, regarded as being related to cannibalism. Creutzfeldt-Jakob disease is the more frequent human prion disease. Its incidence is approximately one case per million per year. Four variants are now recognized: sporadic, familial, iatrogenic and the new variant. The latter represents a distinct clinico-pathological entity. It is now widely accepted that it is due to the same agent responsible for Bovine Spongiform Encephalopathy in cattle. Gerstmann-Straussler-Scheinker disease is a very rare inherited disorder due to a number of different mutations in the PRP gene, characterized by abundant deposits of plaque PrPres in the cerebral grey matter. Fatal familial insomnia is another inherited disorder due to a mutation at codon 178 of the PRP gene associated with methionine on codon 129 of the mutant allele. The main neuropathological change is neuronal loss in the thalamus with little or no spongiosis and usually no PrPres deposition. Following the emergence of new variant CJD in 1996, surveillance of all forms of prion diseases has been now been actively introduced in many European nations in order to determine the true incidence and geographic distribution of these rare disorders in humans.

  13. Progress report of CJD

    International Nuclear Information System (INIS)

    This paper is the progress report of the Russian Nuclear Data Center at F.E.I., Obninsk. Evaluations have been made for dosimetry reactions and neutron reactions. Analysis of the spectra and the production cross sections were made. (a.n.)

  14. Questor's Question

    Science.gov (United States)

    Erickson, Mary; Dock, Michelle Nichols; Eldridge, Laurie

    2009-01-01

    Questor is a curious little bird whose four broad questions are helpful to anyone interested in making art or understanding the art of others. He was designed as a character in an online video for children, "Building on a River: Questor's Tale." The video is narrated by Questor, who relates the 2000 year history of architecture along the Salt…

  15. 75 FR 29768 - Guidance for Industry: Revised Preventive Measures to Reduce the Possible Risk of Transmission of...

    Science.gov (United States)

    2010-05-27

    ...: Revised Preventive Measures to Reduce the Possible Risk of Transmission of Creutzfeldt-Jakob Disease (CJD) and Variant Creutzfeldt-Jakob Disease (vCJD) by Blood and Blood Products; Availability AGENCY: Food... Reduce the Possible Risk of Transmission of Creutzfeldt-Jakob Disease (CJD) and Variant...

  16. MRI of Creutzfeldt-Jakob disease: Imaging features and recommended MRI protocol

    Energy Technology Data Exchange (ETDEWEB)

    Collie, D.A.; Sellar, R.J.; Zeidler, M.; Colchester, A.C.F.; Knight, R.; Will, R.G

    2001-09-01

    Creutzfeldt-Jakob Disease (CJD) is a rare, progressive and invariably fatal neurodegenerative disease characterized by specific histopathological features. Of the four subtypes of CJD described, the commonest is sporadic CJD (sCJD). More recently, a new clinically distinct form of the disease affecting younger patients, known as variant CJD (vCJD), has been identified, and this has been causally linked to the bovine spongiform encephalopathy (BSE) agent in cattle. Characteristic appearances on magnetic resonance imaging (MRI) have been identified in several forms of CJD; sCJD may be associated with high signal changes in the putamen and caudate head and vCJD is usually associated with hyperintensity of the pulvinar (posterior nuclei) of the thalamus. These appearances and other imaging features are described in this article. Using appropriate clinical and radiological criteria and tailored imaging protocols, MRI plays an important part in the in vivodiagnosis of this disease. Collie, D.A. et al. (2001)

  17. Laminar Distribution of the Pathological Changes in Sporadic and Variant Creutzfeldt-Jakob Disease

    Directory of Open Access Journals (Sweden)

    R. A. Armstrong

    2011-01-01

    Full Text Available The laminar distributions of the pathological changes in the cerebral cortex were compared in the prion diseases sporadic Creutzfeldt-Jakob disease (sCJD and variant CJD (vCJD. First, in some cortical regions, the vacuolation (“spongiform change” was more generally distributed across the cortex in sCJD. Second, there was greater neuronal loss in the upper cortex in vCJD and in the lower cortex in sCJD. Third, the “diffuse” and “florid” prion protein (PrPsc deposits were more frequently distributed in the upper cortex in vCJD and the “synaptic” deposits in the lower cortex in sCJD. Fourth, there was a significant gliosis mainly affecting the lower cortex of both disorders. The data suggest that the pattern of cortical degeneration is different in sCJD and vCJD which may reflect differences in aetiology and the subsequent spread of prion pathology within the brain.

  18. Long term survival in a patient with variant Creutzfeldt-Jakob disease treated with intraventricular pentosan polysulphate.

    Science.gov (United States)

    Parry, A; Baker, I; Stacey, R; Wimalaratna, S

    2007-07-01

    Variant Creutzfeldt-Jakob disease (vCJD) is a neurodegenerative disease that principally affects young people and has a median duration of illness of 13 (range 6-39) months. vCJD is incurable and there are currently no treatments that conclusively slow the rate of disease progression. However, recent animal studies and isolated case reports have suggested that treatment with intraventricular pentosan polysulphate (PPS) may be beneficial in the treatment of patients with vCJD. We report a case of a 22-year-old male with vCJD treated 19 months after the onset of clinical symptoms with continuous intraventricular PPS (32 microg/kg/day) over a period of 31 months. Treatment with PPS appeared to be safe and well tolerated and was associated with prolonged survival (51 months) when compared to natural history studies. However, PPS treatment did not appear to arrest the progression of the disease. PMID:17314188

  19. Long term survival in a patient with variant Creutzfeldt-Jakob disease treated with intraventricular pentosan polysulphate.

    Science.gov (United States)

    Parry, A; Baker, I; Stacey, R; Wimalaratna, S

    2007-07-01

    Variant Creutzfeldt-Jakob disease (vCJD) is a neurodegenerative disease that principally affects young people and has a median duration of illness of 13 (range 6-39) months. vCJD is incurable and there are currently no treatments that conclusively slow the rate of disease progression. However, recent animal studies and isolated case reports have suggested that treatment with intraventricular pentosan polysulphate (PPS) may be beneficial in the treatment of patients with vCJD. We report a case of a 22-year-old male with vCJD treated 19 months after the onset of clinical symptoms with continuous intraventricular PPS (32 microg/kg/day) over a period of 31 months. Treatment with PPS appeared to be safe and well tolerated and was associated with prolonged survival (51 months) when compared to natural history studies. However, PPS treatment did not appear to arrest the progression of the disease.

  20. The First Report of a Patient with Probable Variant Creutzfeldt-Jakob Disease in Turkey

    Directory of Open Access Journals (Sweden)

    Demet Özbabalık Adapınar

    2011-12-01

    Full Text Available Variant Creutzfeldt-Jakob disease (vCJD was first reported in the UK in 1996. Here, we report the first Turkish case of vCJD. A 47-year-old man, who has never lived outside of Turkey and had had no transfusion, was admitted to the University Hospital with speech disorder, cognitive decline and ataxia following depression, irritability, and personality change. The immunoassay of the 14-3-3 protein in the cerebrospinal fluid was negative. Brain magnetic resonance imaging revealed high-signal lesions involving the bilateral caudate and lentiform nucleus on T2- and diffusion-weighted imaging. The patient developed akinetic mutism 10 months after disease onset. The clinical presentation and neuroimaging findings were compatible with the vCJD cases reported since 1996 and met the World Health Organization’s case definition for probable vCJD.

  1. Impacto da recusa de candidatos à doação de sangue devido aos critérios para prevenção da doença de Creutzfeldt-Jacob e sua variante Impact of deferral criteria on prevention of Creutzfeldt-Jakob disease and its variant among blood donors in São Paulo, Brazil

    Directory of Open Access Journals (Sweden)

    Cesar Almeida Neto

    2005-06-01

    Full Text Available A doença de Creutzfeldt-Jacob (CJD e sua variante (vCJD são doenças neurológicas fatais, degenerativas, com longo período de incubação. Recentemente, um possível caso de transmissão de vCJD por transfusão sangüínea foi descrito. A partir de 2001 adotamos critérios para recusa de candidatos baseados em dados da literatura, Portarias e Resoluções do Ministério da Saúde. Avaliamos retrospectivamente o porcentual de recusas anuais na triagem clínica de 1.015.587 candidatos à doação, referentes aos critérios relacionados a CJD e vCJD, de janeiro de 2001 a dezembro de 2004. Este porcentual correspondeu a 0,0049% em 2001, 0,0051% em 2002, 0,092% em 2003 e 0,098% em 2004, representando recusa definitiva de 726 (0,068% candidatos. A causa mais freqüente de recusa por CJD ou vCJD foi permanência no Reino Unido > 6 meses (259 recusas seguido de transplante de córnea (203 recusas e uso de hormônio do crescimento de origem humana (151 recusas. Embora o número de recusas relacionados a CJD e sua variante seja baixo em nossa Instituição, observamos um aumento gradativo anual, que provavelmente relaciona-se à adição de novos critérios. Diferentemente de outros países, estas recusas não afetaram nosso estoque de sangue e componentes. Com os dados obtidos, consideramos que, na nossa população, podemos manter o "Princípio da Precaução" sem causar prejuízo no fornecimento de sangue e componentes aos nossos pacientes.Creutzfeldt-Jakob disease (CJD and its variant (vCJD are degenerative and fatal neurological diseases with a long incubation period. Recent studies have described a potential association between vCJD and blood transmission. The aim of this study is to evaluate the impact of the deferral criteria for CJD and vCJD in our institution since their implementation in 2001. Based on scientific data, we have adopted deferral criteria for the prevention of CJD and vCJD through blood transfusion since 2001. Blood donors are

  2. Characterization of variant Creutzfeldt-Jakob disease prions in prion protein-humanized mice carrying distinct codon 129 genotypes.

    Science.gov (United States)

    Takeuchi, Atsuko; Kobayashi, Atsushi; Ironside, James W; Mohri, Shirou; Kitamoto, Tetsuyuki

    2013-07-26

    To date, all clinical variant Creutzfeldt-Jakob disease (vCJD) patients are homozygous for methionine at polymorphic codon 129 (129M/M) of the prion protein (PrP) gene. However, the appearance of asymptomatic secondary vCJD infection in individuals with a PRNP codon 129 genotype other than M/M and transmission studies using animal models have raised the concern that all humans might be susceptible to vCJD prions, especially via secondary infection. To reevaluate this possibility and to analyze in detail the transmission properties of vCJD prions to transgenic animals carrying distinct codon 129 genotype, we performed intracerebral inoculation of vCJD prions to humanized knock-in mice carrying all possible codon 129 genotypes (129M/M, 129M/V, or 129V/V). All humanized knock-in mouse lines were susceptible to vCJD infection, although the attack rate gradually decreased from 129M/M to 129M/V and to 129V/V. The amount of PrP deposition including florid/amyloid plaques in the brain also gradually decreased from 129M/M to 129M/V and to 129V/V. The biochemical properties of protease-resistant abnormal PrP in the brain and transmissibility of these humanized mouse-passaged vCJD prions upon subpassage into knock-in mice expressing bovine PrP were not affected by the codon 129 genotype. These results indicate that individuals with the 129V/V genotype may be more susceptible to secondary vCJD infection than expected and may lack the neuropathological characteristics observed in vCJD patients with the 129M/M genotype. Besides the molecular typing of protease-resistant PrP in the brain, transmission studies using knock-in mice carrying bovine PrP may aid the differential diagnosis of secondary vCJD infection, especially in individuals with the 129V/V genotype.

  3. Creutzfeldt-Jakob Disease Fact Sheet for Healthcare Workers and Morticians

    Science.gov (United States)

    ... Career Awards Enhancing Diversity Find People About NINDS Creutzfeldt-Jakob Disease Fact Sheet for Healthcare Workers and Morticians Description ... form of CJD (vCJD), largely in Britain, to mad cow disease (bovine spongiform encephalopathy or BSE), a deadly brain ...

  4. Asking Questions in Academia

    DEFF Research Database (Denmark)

    Hansen, Annette Skovsted

    2014-01-01

    Motivation for the activity In academia the most important skill is to ask academically relevant and sound questions. This is not easy and students need to practice asking questions orally and in writing before they write research papers.......Motivation for the activity In academia the most important skill is to ask academically relevant and sound questions. This is not easy and students need to practice asking questions orally and in writing before they write research papers....

  5. Classroom Questioning Strategies

    Institute of Scientific and Technical Information of China (English)

    陈小林

    2013-01-01

      Interaction has been playing a more and more important role in language research since the early 1970s,when the communicative teaching method was widely applied in language teaching. Questioning is the most common classroom interaction. This thesis analyzed the influence on students' immediate oral production by applying different teacher questioning strategies including teacher's question types,teacher question modification and teacher feedback.

  6. Improving Student Question Classification

    Science.gov (United States)

    Heiner, Cecily; Zachary, Joseph L.

    2009-01-01

    Students in introductory programming classes often articulate their questions and information needs incompletely. Consequently, the automatic classification of student questions to provide automated tutorial responses is a challenging problem. This paper analyzes 411 questions from an introductory Java programming course by reducing the natural…

  7. Making Questions Flow

    Science.gov (United States)

    Rothstein, Dan; Santana, Luz; Minigan, Andrew P.

    2015-01-01

    Getting students to ask questions can feel like pulling teeth. How can teachers transform that feeling and create classrooms that come alive with questions? The authors, developers of the question formulation technique, suggest two simple changes: First, teachers need to give students both a structure and the opportunity to practice generating…

  8. Characterization of bovine and human cellular prion protein expressed in the central nervous system and in lymphoid organs.

    OpenAIRE

    Defaweux, Valérie; Stramiello, Sara; Capellari, Sabina; Antoine, Nadine; C Demonceau; Dorban, Gauthier; Jolois, Olivier; Heinen, Ernst; Parchi, Piero

    2005-01-01

    Prion cell tropism varies significantly among animal species, depending on both the agent strain and host-specific factors. For example, prions show high lymphotropism in scrapie infected sheep and vCJD, but little, if any, in sCJD or BSE. In particular, the BSE strain is associate with significant PrP-res accumulation in tonsils, spleen and appendix in humans, whereas, it is largely confined to the nervous system in infected cattle. So, it appears that, at least in the case of BSE and vCJD, ...

  9. What is a Question?

    OpenAIRE

    Kevin H. Knuth

    2004-01-01

    A given question can be defined in terms of the set of statements or assertions that answer it. Application of logical inference to these sets of assertions allows one to derive the logic of inquiry among questions. There are interesting symmetries between the logics of inference and inquiry; where probability describes the degree to which a premise implies an assertion, there exists an analogous measure that describes the bearing or relevance that a question has on an outstanding issue. Thes...

  10. Asking the Right Questions

    DEFF Research Database (Denmark)

    Richter, Line

    Based on fieldwork in Mali this paper discusses the role of anthropology (and the anthropologist) in a large public health research project on children's health. In the uncertainty and disquiet that comes with the battle to combat and avoid diseases in a setting where poverty and abysmal diseases......, is the ability to move beyond even the best hidden assumptions and question our own questions, thereby enabling us to ask the right questions....

  11. Questions and information systems

    CERN Document Server

    Lauer, Thomas W; Graesser, Arthur C

    2013-01-01

    The design and functioning of an information system improve to the extent that the system can handle the questions people ask. Surprisingly, however, researchers in the cognitive, computer, and information sciences have not thoroughly examined the multitude of relationships between information systems and questions -- both question asking and answering. The purpose of this book is to explicitly examine these relationships. Chapter contributors believe that questions play a central role in the analysis, design, and use of different kinds of natural or artificial information systems such as huma

  12. Human prion diseases in the United States.

    Directory of Open Access Journals (Sweden)

    Robert C Holman

    Full Text Available BACKGROUND: Prion diseases are a family of rare, progressive, neurodegenerative disorders that affect humans and animals. The most common form of human prion disease, Creutzfeldt-Jakob disease (CJD, occurs worldwide. Variant CJD (vCJD, a recently emerged human prion disease, is a zoonotic foodborne disorder that occurs almost exclusively in countries with outbreaks of bovine spongiform encephalopathy. This study describes the occurrence and epidemiology of CJD and vCJD in the United States. METHODOLOGY/PRINCIPAL FINDINGS: Analysis of CJD and vCJD deaths using death certificates of US residents for 1979-2006, and those identified through other surveillance mechanisms during 1996-2008. Since CJD is invariably fatal and illness duration is usually less than one year, the CJD incidence is estimated as the death rate. During 1979 through 2006, an estimated 6,917 deaths with CJD as a cause of death were reported in the United States, an annual average of approximately 247 deaths (range 172-304 deaths. The average annual age-adjusted incidence for CJD was 0.97 per 1,000,000 persons. Most (61.8% of the CJD deaths occurred among persons >or=65 years of age for an average annual incidence of 4.8 per 1,000,000 persons in this population. Most deaths were among whites (94.6%; the age-adjusted incidence for whites was 2.7 times higher than that for blacks (1.04 and 0.40, respectively. Three patients who died since 2004 were reported with vCJD; epidemiologic evidence indicated that their infection was acquired outside of the United States. CONCLUSION/SIGNIFICANCE: Surveillance continues to show an annual CJD incidence rate of about 1 case per 1,000,000 persons and marked differences in CJD rates by age and race in the United States. Ongoing surveillance remains important for monitoring the stability of the CJD incidence rates, and detecting occurrences of vCJD and possibly other novel prion diseases in the United States.

  13. Questioning the Text.

    Science.gov (United States)

    Ditor, Rachel

    2003-01-01

    Outlines a dramaturg's process when working on three different plays. Contends that the myriad variations on the question "what will happen next?" serve as the basic architecture on which the dynamic relationship between the story/storytellers and the audience is built. Observes that the continual planning and answering of questions is story. (PM)

  14. Generating ethnographic research questions

    DEFF Research Database (Denmark)

    Friberg, Torbjörn

    2015-01-01

    imagination, as a prerequisite for generating alternative research questions. The third part makes explicit anthropologist Maurice Godelier's theoretical imagination, carving out some specific theoretical parts which may be used in the generating process. The conclusion then suggests a number of questions...

  15. Legal Philosophy - Five Questions

    DEFF Research Database (Denmark)

    This collection gathers together a host of the most eminent contemporary legal philosophers, who writes about their take on legal philosophy, its fundamental questions and potential.......This collection gathers together a host of the most eminent contemporary legal philosophers, who writes about their take on legal philosophy, its fundamental questions and potential....

  16. Epistemology: 5 Questions

    DEFF Research Database (Denmark)

    Epistemology: 5 Questions is a collection of short interviews based on 5 questions presented to some of the most influential and prominent scholars in epistemology. We hear their views on epistemology with particular emphasis on the intersection between mainstream and formal approaches to the fie......; the aim, scope, the future direction of epistemology and how their work fits in these respects...

  17. Prion diseases as transmissible zoonotic diseases.

    Science.gov (United States)

    Lee, Jeongmin; Kim, Su Yeon; Hwang, Kyu Jam; Ju, Young Ran; Woo, Hee-Jong

    2013-02-01

    Prion diseases, also called transmissible spongiform encephalopathies (TSEs), lead to neurological dysfunction in animals and are fatal. Infectious prion proteins are causative agents of many mammalian TSEs, including scrapie (in sheep), chronic wasting disease (in deer and elk), bovine spongiform encephalopathy (BSE; in cattle), and Creutzfeldt-Jakob disease (CJD; in humans). BSE, better known as mad cow disease, is among the many recently discovered zoonotic diseases. BSE cases were first reported in the United Kingdom in 1986. Variant CJD (vCJD) is a disease that was first detected in 1996, which affects humans and is linked to the BSE epidemic in cattle. vCJD is presumed to be caused by consumption of contaminated meat and other food products derived from affected cattle. The BSE epidemic peaked in 1992 and decreased thereafter; this decline is continuing sharply owing to intensive surveillance and screening programs in the Western world. However, there are still new outbreaks and/or progression of prion diseases, including atypical BSE, and iatrogenic CJD and vCJD via organ transplantation and blood transfusion. This paper summarizes studies on prions, particularly on prion molecular mechanisms, BSE, vCJD, and diagnostic procedures. Risk perception and communication policies of the European Union for the prevention of prion diseases are also addressed to provide recommendations for appropriate government policies in Korea. PMID:24159531

  18. What is a Question?

    Science.gov (United States)

    Knuth, Kevin H.

    2003-03-01

    A given question can be defined in terms of the set of statements or assertions that answer it. Application of logical inference to these sets of assertions allows one to derive the logic of inquiry among questions. There are interesting symmetries between the logics of inference and inquiry; where probability describes the degree to which a premise implies an assertion, there exists an analogous measure that describes the bearing or relevance that a question has on an outstanding issue. These have been extended to suggest that the logic of inquiry results in functional relationships analogous to, although more general than, those found in information theory. Employing lattice theory, I examine in greater detail the structure of the space of assertions and questions demonstrating that the symmetries between the logical relations in each of the spaces derive directly from the lattice structure. Furthermore, I show that while symmetries between the spaces exist, the two lattices are not isomorphic. The lattice of assertions is described by a Boolean lattice 2N, whereas the lattice of assuredly real questions is shown to be a sublattice of the free distributive lattice FD(N) = 22N. Thus there does not exist a one-to-one mapping of assertions to questions, there is no reflection symmetry between the two spaces, and questions in general do not possess complements. Last, with these lattice structures in mind, I discuss the relationship between probability, relevance, and entropy.

  19. Creutzfeldt-Jakob disease in Ireland: epidemiological aspects 1980-2002.

    LENUS (Irish Health Repository)

    Horan, Gail

    2012-02-03

    Surveillance for Creutzfeldt-Jakob disease (CJD) has been carried out in the Republic of Ireland since 1980. Initial surveillance was passive and based on consented autopsy confirmation of CJD in patients in whom there was a high index of clinical suspicion. Since 1999, an active surveillance programme involving formal notification of all suspect CJD cases has been in place. The annual mortality rate has increased from 0.34 cases\\/million in 1980 to 1.27 cases\\/million in 2001. In all, 29 cases have been pathologically confirmed: 1 had variant CJD (vCJD), 1 had iatrogenic human growth hormone-induced CJD and 1 had fatal insomnia. Sporadic CJD (sCJD) accounted for the remainder. This paper details the change in incidence over 22 years as the surveillance programme in Ireland got under way; the increased incidence is attributed to better case ascertainment, as has occurred in other countries where active surveillance programmes have been established.

  20. ON REICH'S OPEN QUESTION

    Institute of Scientific and Technical Information of China (English)

    张石生

    2003-01-01

    Under more general form and more general conditions an affirmative answer to Reich's open question is given. The results presented also extend and improve some recent results of Reich, Shioji, Takahashi and Wittmann.

  1. Seasonal Influenza Questions & Answers

    Science.gov (United States)

    ... Medscape Podcasts Public Service Announcements (PSAs) Virus Images Influenza Types Seasonal Avian Swine Variant Pandemic Other Get ... Submit What's this? Submit Button Past Newsletters Seasonal Influenza, More Information Questions & Answers Language: English Español ...

  2. What is a Question?

    CERN Document Server

    Knuth, K H

    2002-01-01

    A given question can be defined in terms of the set of statements or assertions that answer it. Application of logical inference to these sets of assertions allows one to derive the logic of inquiry among questions. There are interesting symmetries between the logics of inference and inquiry; where probability describes the degree to which a premise implies an assertion, there exists an analogous measure that describes the bearing or relevance that a question has on an outstanding issue. These have been extended to suggest that the logic of inquiry results in functional relationships analogous to, although more general than, those found in information theory. Employing lattice theory, I examine in greater detail the structure of the space of assertions and questions demonstrating that the symmetries between the logical relations in each of the spaces derive directly from the lattice structure. Furthermore, I show that while symmetries between the spaces exist, the two lattices are not isomorphic. The lattice ...

  3. CAT questions and answers

    International Nuclear Information System (INIS)

    This document, prepared in February 1993, addresses the most common questions asked by APS Collaborative Access Teams (CATs). The answers represent the best judgment on the part of the APS at this time. In some cases, details are provided in separate documents to be supplied by the APS. Some of the answers are brief because details are not yet available. The questions are separated into five categories representing different aspects of CAT interactions with the APS: (1) Memorandum of Understanding (MOU), (2) CAT Beamline Review and Construction, (3) CAT Beamline Safety, (4) CAT Beamline Operations, and (5) Miscellaneous. The APS plans to generate similar documents as needed to both address new questions and clarify answers to present questions

  4. Cosmetic Procedure Questions

    Science.gov (United States)

    ... How to Choose the Best Skin Care Products Cosmetic Procedure Questions Want to look younger? Start by ... fillers, neuromodulators (Botox) and hair restoration among others. Cosmetic Questionnaire Print out this PDF version to take ...

  5. Does Poor Dental Health Have a Role in the Emergence of Variant Creutzfeldt Jakob Disease in the United Kingdom?

    Directory of Open Access Journals (Sweden)

    Robert Burnie

    2011-05-01

    Full Text Available Introduction: Variant creutzfeldt jakob disease (vCJD is the hu-man neurological disease known to be caused by the same proteinaceous infectious agent (“prion” that causes Bovine Spongiform Encephalopathy or "Mad Cow Disease". Two un-usual and unexplained characteristics of the vCJD epidemic are its geographical distribution within the UK (about twice as frequent in Scotland and Northern England and its median age of onset of 26 years that has remained unchanged over the fifteen years of the epidemic.The hypothesis: Infection via the dental route as a consequence of poor dental health, most probably the presence of untreated decay may account for the geographical distribution of vCJD in the UK and offer an explanation for the constant median age of onset of the dis-ease by representing a fixed stage in development.Evaluation of the hypothesis: Analysis of existing data indicates that vCJD incidence by region and an index of dental health by region are positively correlated (r=0.737, p= 0.015. The hypothesis that infection via the dental route may explain the constant median age of onset and geographical distribution of vCJD could be investigated further with a case control study based on individual dental records and by further animal experiments to confirm the biological plausibility of this route.

  6. Short TE quantitative proton magnetic resonance spectroscopy in variant Creutzfeldt-Jakob disease

    International Nuclear Information System (INIS)

    Variant Creutzfeldt-Jakob disease (vCJD) is a fatal neurodegerative disorder. Clinical diagnosis is difficult in the early stages as the disease often presents with non-specific psychiatric and neurological symptoms. To investigate the diagnostic potential of quantitative short TE in vivo MRS, and the nature and anatomical distribution of biochemical abnormalities in vCJD, localised single-voxel spectra (TE/TR 30 ms/2,000 ms) were acquired from three brain regions: thalami, caudate nuclei and frontal white matter. Metabolite concentrations and ratios from three patients with definite or probable vCJD were compared with eight normal age-matched controls. Abnormal signal on T2-weighted MRI was apparent in the pulvinar region in all vCJD patients; this region also showed greatly increased myo-inositol [MI] (mean 2.5-fold, P=0.01) and decreased N-acetyl-aspartate (NAA; mean 2-fold, P=0.01). Two patients also showed increased [MI] (z=17, 11; one with decreased NAA, z=-12) in normal-appearing caudate nuclei. The magnitude of metabolite abnormalities in the thalami in moderately advanced vCJD suggests a potential role in earlier diagnosis. Short TE protocols allow the measurement of MI, which adds discriminant power to the MRS examination. (orig.)

  7. Short TE quantitative proton magnetic resonance spectroscopy in variant Creutzfeldt-Jakob disease

    Energy Technology Data Exchange (ETDEWEB)

    Cordery, R.J.; Godbolt, A.; Rossor, M.N. [University College London, Dementia Research Group, Institute of Neurology, London (United Kingdom); Imperial College of Science, Technology and Medicine, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, London (United Kingdom); MacManus, D. [University College London, NMR Research Unit, Department of Clinical Neurology,Institute of Neurology, London (United Kingdom); Waldman, A.D. [University College London, Dementia Research Group, Institute of Neurology, London (United Kingdom); Imperial College of Science, Technology and Medicine, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, London (United Kingdom); Charing Cross Hospital, Department of Imaging, London (United Kingdom); National Hospital for Neurology and Neurosurgery, Dementia Research Group, London (United Kingdom)

    2006-08-15

    Variant Creutzfeldt-Jakob disease (vCJD) is a fatal neurodegerative disorder. Clinical diagnosis is difficult in the early stages as the disease often presents with non-specific psychiatric and neurological symptoms. To investigate the diagnostic potential of quantitative short TE in vivo MRS, and the nature and anatomical distribution of biochemical abnormalities in vCJD, localised single-voxel spectra (TE/TR 30 ms/2,000 ms) were acquired from three brain regions: thalami, caudate nuclei and frontal white matter. Metabolite concentrations and ratios from three patients with definite or probable vCJD were compared with eight normal age-matched controls. Abnormal signal on T2-weighted MRI was apparent in the pulvinar region in all vCJD patients; this region also showed greatly increased myo-inositol [MI] (mean 2.5-fold, P=0.01) and decreased N-acetyl-aspartate (NAA; mean 2-fold, P=0.01). Two patients also showed increased [MI] (z=17, 11; one with decreased NAA, z=-12) in normal-appearing caudate nuclei. The magnitude of metabolite abnormalities in the thalami in moderately advanced vCJD suggests a potential role in earlier diagnosis. Short TE protocols allow the measurement of MI, which adds discriminant power to the MRS examination. (orig.)

  8. Game Theory: 5 Questions

    DEFF Research Database (Denmark)

    Hendricks, Vincent F.

    Game Theory is a collection of short interviews based on 5 questions presented to some of the most influential and prominent scholars in game theory. We hear their views on game theory, its aim, scope, use, the future direction of game theory and how their work fits in these respects....

  9. Transportation questions and answers

    International Nuclear Information System (INIS)

    This document summarizes the transport and handling of radioactive materials in a ''question'' and ''answer'' form. It explains what is radioactive material, how it is shipped, and in case there is a spill, who is responsible for it. It also provides safeguard measures for radioactive materials. (TC)

  10. Questions about elastic waves

    CERN Document Server

    Engelbrecht, Jüri

    2015-01-01

    This book addresses the modelling of mechanical waves by asking the right questions about them and trying to find suitable answers. The questions follow the analytical sequence from elementary understandings to complicated cases, following a step-by-step path towards increased knowledge. The focus is on waves in elastic solids, although some examples also concern non-conservative cases for the sake of completeness. Special attention is paid to the understanding of the influence of microstructure, nonlinearity and internal variables in continua. With the help of many mathematical models for describing waves, physical phenomena concerning wave dispersion, nonlinear effects, emergence of solitary waves, scales and hierarchies of waves as well as the governing physical parameters are analysed. Also, the energy balance in waves and non-conservative models with energy influx are discussed. Finally, all answers are interwoven into the canvas of complexity.

  11. Quantum theory from questions

    CERN Document Server

    Hoehn, Philipp A

    2016-01-01

    We reconstruct the explicit formalism of qubit quantum theory from elementary rules on an observer's information acquisition. Our approach is purely operational: we consider an observer O interrogating a system S with binary questions and define S's state as O's `catalogue of knowledge' about S; no ontic assumptions are necessary. From the rules we derive the state spaces for N qubits and show that (a) they coincide with the set of density matrices over N qubit Hilbert spaces; (b) states evolve unitarily under the group $\\rm{PSU}(2^N)$ according to the von Neumann evolution equation; and (c) the binary questions by means of which O interrogates the systems corresponds to projective measurements on Pauli operators with outcome probabilities given by the Born rule. Besides offering a novel conceptual perspective on qubit quantum theory, the reconstruction also unravels new structural insights. Namely, we show that, in a quadratic information measure, (d) qubits satisfy informational complementarity inequalities...

  12. Familial CJD associated PrP mutants within transmembrane region induced Ctm-PrP retention in ER and triggered apoptosis by ER stress in SH-SY5Y cells.

    Directory of Open Access Journals (Sweden)

    Xin Wang

    Full Text Available BACKGROUND: Genetic prion diseases are linked to point and inserted mutations in the prion protein (PrP gene that are presumed to favor conversion of the cellular isoform of PrP (PrP(C to the pathogenic one (PrP(Sc. The pathogenic mechanisms and the subcellular sites of the conversion are not completely understood. Here we introduce several PRNP gene mutations (such as, PrP-KDEL, PrP-3AV, PrP-A117V, PrP-G114V, PrP-P102L and PrP-E200K into the cultured cells in order to explore the pathogenic mechanism of familial prion disease. METHODOLOGY/PRINCIPAL FINDINGS: To address the roles of aberrant retention of PrP in endoplasmic reticulum (ER, the recombinant plasmids expressing full-length human PrP tailed with an ER signal peptide at the COOH-terminal (PrP-KDEL and PrP with three amino acids exchange in transmembrane region (PrP-3AV were constructed. In the preparations of transient transfections, 18-kD COOH-terminal proteolytic resistant fragments (Ctm-PrP were detected in the cells expressing PrP-KDEL and PrP-3AV. Analyses of the cell viabilities in the presences of tunicamycin and brefeldin A revealed that expressions of PrP-KDEL and PrP-3AV sensitized the transfected cells to ER stress stimuli. Western blots and RT-PCR identified the clear alternations of ER stress associated events in the cells expressing PrP-KDEL and PrP-3AV that induced ER mediated apoptosis by CHOP and caspase-12 apoptosis pathway. Moreover, several familial CJD related PrP mutants were transiently introduced into the cultured cells. Only the mutants within the transmembrane region (G114V and A117V induced the formation of Ctm-PrP and caused the ER stress, while the mutants outside the transmembrane region (P102L and E200K failed. CONCLUSIONS/SIGNIFICANCE: The data indicate that the retention of PrP in ER through formation of Ctm-PrP results in ER stress and cell apoptosis. The cytopathic activities caused by different familial CJD associated PrP mutants may vary, among them

  13. Trick questions: cosmopolitan hospitality

    OpenAIRE

    Eleanor Byrne

    2013-01-01

    Byrne’s paper consists of two parallel texts. The first explores the limits of cosmopolitanism in practice, taking as its subject the Life in the UK Citizenship Test, inaugurated under the Labour Government in 2005. It argues that the test exemplifies the predicament of all attempts at cosmopolitan hospitality as unconditional welcoming, through a discussion of the relation between questioning and welcoming the stranger. Establishing the relationship between cosmopolitanism and hospitality a...

  14. Quantum theory from questions

    OpenAIRE

    Hoehn, Philipp A; Wever, Christopher(Institute of Nuclear and Particle Physics, NCSR ‘Demokritos’,, Agia Paraskevi, 15310, Greece)

    2015-01-01

    We reconstruct the explicit formalism of qubit quantum theory from elementary rules on an observer's information acquisition. Our approach is purely operational: we consider an observer O interrogating a system S with binary questions and define S's state as O's `catalogue of knowledge' about S. From the rules we derive the state spaces for N elementary systems and show that (a) they coincide with the set of density matrices over an N-qubit Hilbert space; (b) states evolve unitarily under the...

  15. Eight Questions about Corruption

    OpenAIRE

    Jakob Svensson

    2005-01-01

    This paper will discuss eight frequently asked questions about public corruption: (1) What is corruption? (2) Which countries are the most corrupt? (3) What are the common characteristics of countries with high corruption? (4) What is the magnitude of corruption? (5) Do higher wages for bureaucrats reduce corruption? (6) Can competition reduce corruption? (7) Why have there been so few (recent) successful attempts to fight corruption? (8) Does corruption adversely affect growth?

  16. Questioning Many Mysteries

    Science.gov (United States)

    Martin, Sara F.

    2015-04-01

    The first section of this memoir queries my formative years. Indirectly I address the question, did my childhood and early years make a difference in my choice of career? Why and how did I begin my journey to becoming a scientist? Did I choose the field of solar astronomy or did circumstances dictate it for me? In the second section, I travel through my work environments and experiences, talking about interactions and aspects of being a scientist that do not appear in our research papers. What parts of my research were happenstances and what parts did I plan? What does it feel like to be on scientific quests? Using examples in my journey, I also turn to questions that have intrigued me throughout my sojourn as a solar astronomer. How do scientific discoveries come about? What factors lead to little discoveries? And what factors lead to major exciting discoveries? Are there timely questions we do not think to ask? How can small, seemingly scattered pieces of knowledge suddenly coalesce into a deeper understanding - what is called the "Aha!" experience - the times when our mental light switches on, and with child-like wonder we behold a "big picture"?

  17. Social Epistemology: 5 Questions

    DEFF Research Database (Denmark)

    Social Epistemology: 5 Questions is a collection of interviews with some of the world’s most influential scholars working on social epistemology from a range of disciplinary perspectives. We hear their views on social epistemology; its aim, scope, use, broader intellectual environment, future...... direction, and how the work of the interviewees fits in these respects. Interviews with David Bloor, Cristina Bicchieri, Richard Bradley, Lorraine Code, Hans van Ditmarsch, Miranda Fricker, Steve Fuller, Sanford Goldberg, Alvin Goldman, Philip Kitcher, Martin Kusch, Jennifer Lackey, Helen E. Longino, Philip...

  18. The Question Concerning Thinking

    DEFF Research Database (Denmark)

    Riis, Søren

    2008-01-01

    Martin Heidegger's thought-provoking essay "The Question Concerning Technology" (1977a) placed technology at the heart of philosophy. Heidegger tried to show that the essence of technology provokes humans to think about the world in a very dangerous way. Yet if we follow Heidegger's analysis of t...... concerning thinking reflects these consequences and finally strives to find another way to think about thinking - a way that brings us back to another of Heidegger's thoughts and that makes it possible to appreciate the work of thought...

  19. Trick questions: cosmopolitan hospitality

    Directory of Open Access Journals (Sweden)

    Eleanor Byrne

    2013-08-01

    Full Text Available Byrne’s paper consists of two parallel texts. The first explores the limits of cosmopolitanism in practice, taking as its subject the Life in the UK Citizenship Test, inaugurated under the Labour Government in 2005. It argues that the test exemplifies the predicament of all attempts at cosmopolitan hospitality as unconditional welcoming, through a discussion of the relation between questioning and welcoming the stranger. Establishing the relationship between cosmopolitanism and hospitality as envisaged in Derrida’s reading of Kant it asks what kind of cosmopolitan hospitality is either possible or desirable by exploring what Derrida calls the ‘perversions’ inherent in the structures of hospitality. It focuses on the concept of the ‘trick questions’ that the state asks the foreigner observed by Derrida in his reading of The Apology of Socrates; questions that seem to invite answers but foreclose the possibilities of a free response. The second text asks how this logic that Derrida identifies can be pushed or coaxed into new ways of addressing the perceived threats of ‘unconditional’ hospitality through a reading of ‘unconditional hospitality’ as queer in the work of Tove Jansson.

  20. Rapid and Highly Sensitive Detection of Variant Creutzfeldt-Jakob Disease Abnormal Prion Protein on Steel Surfaces by Protein Misfolding Cyclic Amplification: Application to Prion Decontamination Studies.

    Science.gov (United States)

    Belondrade, Maxime; Nicot, Simon; Béringue, Vincent; Coste, Joliette; Lehmann, Sylvain; Bougard, Daisy

    2016-01-01

    The prevalence of variant Creutzfeldt-Jakob disease (vCJD) in the population remains uncertain, although it has been estimated that 1 in 2000 people in the United Kingdom are positive for abnormal prion protein (PrPTSE) by a recent survey of archived appendix tissues. The prominent lymphotropism of vCJD prions raises the possibility that some surgical procedures may be at risk of iatrogenic vCJD transmission in healthcare facilities. It is therefore vital that decontamination procedures applied to medical devices before their reprocessing are thoroughly validated. A current limitation is the lack of a rapid model permissive to human prions. Here, we developed a prion detection assay based on protein misfolding cyclic amplification (PMCA) technology combined with stainless-steel wire surfaces as carriers of prions (Surf-PMCA). This assay allowed the specific detection of minute quantities (10-8 brain dilution) of either human vCJD or ovine scrapie PrPTSE adsorbed onto a single steel wire, within a two week timeframe. Using Surf-PMCA we evaluated the performance of several reference and commercially available prion-specific decontamination procedures. Surprisingly, we found the efficiency of several marketed reagents to remove human vCJD PrPTSE was lower than expected. Overall, our results demonstrate that Surf-PMCA can be used as a rapid and ultrasensitive assay for the detection of human vCJD PrPTSE adsorbed onto a metallic surface, therefore facilitating the development and validation of decontamination procedures against human prions.

  1. Rapid and Highly Sensitive Detection of Variant Creutzfeldt-Jakob Disease Abnormal Prion Protein on Steel Surfaces by Protein Misfolding Cyclic Amplification: Application to Prion Decontamination Studies.

    Directory of Open Access Journals (Sweden)

    Maxime Belondrade

    Full Text Available The prevalence of variant Creutzfeldt-Jakob disease (vCJD in the population remains uncertain, although it has been estimated that 1 in 2000 people in the United Kingdom are positive for abnormal prion protein (PrPTSE by a recent survey of archived appendix tissues. The prominent lymphotropism of vCJD prions raises the possibility that some surgical procedures may be at risk of iatrogenic vCJD transmission in healthcare facilities. It is therefore vital that decontamination procedures applied to medical devices before their reprocessing are thoroughly validated. A current limitation is the lack of a rapid model permissive to human prions. Here, we developed a prion detection assay based on protein misfolding cyclic amplification (PMCA technology combined with stainless-steel wire surfaces as carriers of prions (Surf-PMCA. This assay allowed the specific detection of minute quantities (10-8 brain dilution of either human vCJD or ovine scrapie PrPTSE adsorbed onto a single steel wire, within a two week timeframe. Using Surf-PMCA we evaluated the performance of several reference and commercially available prion-specific decontamination procedures. Surprisingly, we found the efficiency of several marketed reagents to remove human vCJD PrPTSE was lower than expected. Overall, our results demonstrate that Surf-PMCA can be used as a rapid and ultrasensitive assay for the detection of human vCJD PrPTSE adsorbed onto a metallic surface, therefore facilitating the development and validation of decontamination procedures against human prions.

  2. Rapid and Highly Sensitive Detection of Variant Creutzfeldt-Jakob Disease Abnormal Prion Protein on Steel Surfaces by Protein Misfolding Cyclic Amplification: Application to Prion Decontamination Studies.

    Science.gov (United States)

    Belondrade, Maxime; Nicot, Simon; Béringue, Vincent; Coste, Joliette; Lehmann, Sylvain; Bougard, Daisy

    2016-01-01

    The prevalence of variant Creutzfeldt-Jakob disease (vCJD) in the population remains uncertain, although it has been estimated that 1 in 2000 people in the United Kingdom are positive for abnormal prion protein (PrPTSE) by a recent survey of archived appendix tissues. The prominent lymphotropism of vCJD prions raises the possibility that some surgical procedures may be at risk of iatrogenic vCJD transmission in healthcare facilities. It is therefore vital that decontamination procedures applied to medical devices before their reprocessing are thoroughly validated. A current limitation is the lack of a rapid model permissive to human prions. Here, we developed a prion detection assay based on protein misfolding cyclic amplification (PMCA) technology combined with stainless-steel wire surfaces as carriers of prions (Surf-PMCA). This assay allowed the specific detection of minute quantities (10-8 brain dilution) of either human vCJD or ovine scrapie PrPTSE adsorbed onto a single steel wire, within a two week timeframe. Using Surf-PMCA we evaluated the performance of several reference and commercially available prion-specific decontamination procedures. Surprisingly, we found the efficiency of several marketed reagents to remove human vCJD PrPTSE was lower than expected. Overall, our results demonstrate that Surf-PMCA can be used as a rapid and ultrasensitive assay for the detection of human vCJD PrPTSE adsorbed onto a metallic surface, therefore facilitating the development and validation of decontamination procedures against human prions. PMID:26800081

  3. From Questions to Queries

    Directory of Open Access Journals (Sweden)

    M. Drlík

    2007-12-01

    Full Text Available The extension of (Internet databases forceseveryone to become more familiar with techniques of datastorage and retrieval because users’ success often dependson their ability to pose right questions and to be able tointerpret their answers. University programs pay moreattention to developing database programming skills than todata exploitation skills. To educate our students to become“database users”, the authors intensively exploit supportivetools simplifying the production of database elements astables, queries, forms, reports, web pages, and macros.Videosequences demonstrating “standard operations” forcompleting them have been prepared to enhance out-ofclassroomlearning. The use of SQL and other professionaltools is reduced to the cases when the wizards are unable togenerate the intended construct.

  4. The social question revisited

    DEFF Research Database (Denmark)

    Kenneth, Petersson; Olsson, Ulf; Krejsler, John B.

    2015-01-01

    of social and political unrest, poverty and lack of morality. In the name of European Union social integration is thus organized differently as compared to former times. There are, nevertheless similarities. In both cases educational systems become key arenas for integrating social groups......The focus of this chapter is the re-installation of the social question as a historical practice. The purpose is to investigate how historic figures return and are applied in contemporary political discourses, more precisely in the context of education, education policy and teacher education...... and raising the level of knowledge and competences in society. Higher education, in this case teacher education, is supposed to develop potentials of individuals and maximize “their contribution to a sustainable and democratic knowledge-based society.” Consequently; student cohorts should reflect...

  5. Nanodesign: some basic questions

    CERN Document Server

    Schommers, Wolfram

    2013-01-01

    There is no doubt that nanoscience will be the dominant direction for technology in this century, and that this science will influence our lives to a large extent as well as open completely new perspectives on all scientific and technological disciplines. To be able to produce optimal nanosystems with tailor-made properties, it is necessary to analyze and construct such systems in advance by adequate theoretical and computational methods. Since we work in nanoscience and nanotechnology at the ultimate level, we have to apply the basic laws of physics. What methods and tools are relevant here? The book gives an answer to this question. The background of the theoretical methods and tools is critically discussed, and also the world view on which these physical laws are based. Such a debate is not only of academic interest but is of highly general concern, and this is because we constantly move in nanoscience and nanotechnology between two extreme poles, between infinite life and total destruction . On the one ...

  6. Quantitative Risk Assessment of Bovine Spongiform Encephalopathy

    Science.gov (United States)

    Tsutsui, Toshiyuki; Kasuga, Fumiko

    Bovine spongiform encephalopathy (BSE) is a progressive neurological disease of cattle affecting the central nervous system and was first diagnosed in the United Kingdom (UK) in 1986 (Wells et al., 1987). This disease is one of the transmissible spongiform encephalopathy (TSE) which includes Creutzfeldt-Jakob disease (CJD) in humans and scrapie in sheep. The causative agent of TSE is considered to be an abnormal form of prion protein. However, the details of its pathogenic mechanism have not been fully identified. Scrapie, which causes neurological symptoms in sheep and goats, has existed in the UK for 200 years (Hoinville, 1996) and spread across the rest of the world in the 1900s (Detwiler & Baylis, 2003). There has been no report so far that scrapie can be transmitted to humans. Initially, BSE was also considered as a disease affecting only animals. However, a variant type of Creutzfeldt-Jakob disease (vCJD) was first reported in the UK, and exposure to a BSE agent was suspected (Collinge, Sidle, Meads, Ironside, & Hill, 1996). vCJD is clinically and pathologically different from the sporadic type of CJD, and age at clinical onset of vCJD is younger than sporadic type (Will et al., 1996). Since the UK government announced the possible association between BSE and vCJD in 1996, BSE has become a huge public health concern all over the world. Of particular concern about vCJD, the fatal disease in younger age, distorted consumer confidence in beef safety, and as a result reduced beef consumption has been seen in many BSE-affected countries.

  7. The Questions of Liberal Education

    Science.gov (United States)

    Arcilla, Rene V.

    2007-01-01

    There is a certain kind of liberal educator who bases his or her practice on a particular attitude toward the "Big Questions." The questions of fundamental literacy in K-12 education, or of expertise in vocational and professional education, may be just as important, but they are seen as quite different in kind. Indeed, the questions of liberal…

  8. Disjunctive questions, intonation, and highlighting

    NARCIS (Netherlands)

    F. Roelofsen; S. van Gool

    2009-01-01

    This paper examines how intonation affects the interpretation of disjunctive questions. The semantic effect of a question is taken to be three-fold. First, it raises an issue. In the tradition of inquisitive semantics, we model this by assuming that a question proposes several possible updates of th

  9. Does Anyone Have Any Questions?

    Science.gov (United States)

    Finkelstein, Judith M.; Ritter, Virginia F.

    The purpose of this study was to determine if answering a child's question with a question produces further analytical questioning by the child. A sample of 80 children in nursery-kindergarten, first, second and third grades (ages ranging from 4-9 years) were divided into two groups. An abstract painting by Kandinsky was shown individually to each…

  10. Questions for Music Education Research

    Science.gov (United States)

    Jorgensen, Estelle R.

    2008-01-01

    In addressing the question-set "What questions do music education researchers need to address?", an illustrative list of juxtaposed descriptive and normative questions is sketched as follows: What are and should be the dimensions of music education? What are and should be the institutional agencies of music education? What are and should be the…

  11. Radiological assessment of Creutzfeldt-Jakob disease

    Energy Technology Data Exchange (ETDEWEB)

    Tschampa, Henriette J.; Urbach, Horst [University of Bonn, Department of Radiology, Bonn (Germany); Zerr, Inga [University of Goettingen, National Reference Center for TSE Surveillance at the Department of Neurology, Goettingen (Germany)

    2007-05-15

    Creutzfeldt-Jakob disease is a rare fatal neurodegenerative disorder, characterized by rapidly progressive dementia and neurological signs. There is a need for early and accurate clinical diagnosis in order to exclude any treatable disorder. Additionally, it is of public interest to differentiate the sporadic form of the disease from the variant CJD type (vCJD), which is probably transmitted from cattle infected with bovine spongiform encephalopathy (BSE). High signal in the striatum on T2-weighted, FLAIR and diffusion weighted (DW) MRI as well as cortical high signal in FLAIR and DW MRI are the classical findings in sCJD. The ''pulvinar sign'', defined as high signal in the pulvinar thalami that is brighter than potential additional high signal in the basal ganglia, is considered pathognomonic for vCJD. (orig.)

  12. Arts and Techniques of Questioning

    Institute of Scientific and Technical Information of China (English)

    管楠

    2012-01-01

      Most learners learn English from teachers in classrooms, therefore, classroom instruction is very important. However, teachers’questioning plays a very significant part in classroom teaching. It is not only an important part of classroom interaction but also an effective way of learning second language as wel. On the one hand, it is through question and answer exchange that teachers interactwithstudents.Onthe other hand, it isalsothroughinteractionwiththeirteachersand peers that ESLlearners learn the target language. Teachers’ aims of questioning, question types, teachers’modification of questions, the wait-time, the feedback and the assessment providedby teacherswil affectclassroom interaction.

  13. Can multiple-choice questions simulate free-response questions?

    CERN Document Server

    Lin, Shih-Yin

    2016-01-01

    We discuss a study to evaluate the extent to which free-response questions could be approximated by multiple-choice equivalents. Two carefully designed research-based multiple-choice questions were transformed into a free-response format and administered on the final exam in a calculus-based introductory physics course. The original multiple-choice questions were administered in another similar introductory physics course on final exam. Findings suggest that carefully designed multiple-choice questions can reflect the relative performance of the free-response questions while maintaining the benefits of ease of grading and quantitative analysis, especially if the different choices in the multiple-choice questions are weighted to reflect the different levels of understanding that students display.

  14. Harnessing prions as test agents for the development of broad-range disinfectants

    OpenAIRE

    Wagenführ, Katja; Beekes, Michael

    2012-01-01

    The development of disinfectants with broad-range efficacy against bacteria, viruses, fungi, protozoa and prions constitutes an ongoing challenge. Prions, the causative agents of transmissible spongiform encephalopathies (TSEs) such as Creutzfeldt-Jakob disease (CJD) or its variant (vCJD) rank among the pathogens with the highest resistance to disinfection. Pilot studies have shown that different procedures devised for prion disinfection were also highly effective against microbial pathogens....

  15. Cows for fear: is BSE a threat to human health? Bovine spongiform encephalopathy.

    OpenAIRE

    Josephson, J

    1998-01-01

    In 1996, a new variant of Creutzfeldt-Jakob disease (vCJD)-a disease that causes lack of coordination, muscle twitching or jerking, dementia, and, eventually, death-suddenly appeared in Great Britain. It is believed that the victims contracted the disease from eating the beef of cattle stricken with bovine spongiform encephalopathy (BSE), or mad cow disease. As of December 1997, at least 25 people in the United Kingdom and France have contracted vCJD.

  16. Guided Discovery with Socratic Questioning

    Directory of Open Access Journals (Sweden)

    M. Hakan TURKCAPAR

    2015-03-01

    Full Text Available “The Socratic method” is a way of teaching philosophical thinking and knowledge by asking questions. It was first used by in ancient times by the Greek philosopher Socrates who taught his followers by asking questions; these conversations between them are known as “Socratic dialogues”. In this methodology, no new knowledge is taught to the individual; rather, the individual is guided to remember and rediscover what was formerly known through this process. The main method used in cognitive therapy is guided discovery. There are various methods of guided discovery in cognitive therapy. The form of verbal exchange between the therapist and client which is used during the process of cognitive behavioral therapy is known as “socratic questioning”. In this method the goal is to make the client rediscover, with a series of questions, a piece of knowledge which he could otherwise know but is not presently conscious of. The Socratic Questioning consists of several steps, including: identifying the problem by listening to the client and making reflections, finding alternatives by examining and evaluating, reidentification by using the newly rediscovered information and questioning the old distorted belief, and reaching a new conclusion and applying it. Question types used during these procedures are: questions for collecting information, questions revealing meanings, questions revealing beliefs, questions about behaviours during similar past experiences, analytic questions and analytic synthesis questions. In order to make the patient feel understood, it is important to be empathetic and summarize the problem during the interview. In this text, steps of Socratic Questioning-Guided Discovery will be reviewed with sample dialogues provided for each step.

  17. Cultures in Community Question Answering

    OpenAIRE

    Kayes, Imrul; Kourtellis, Nicolas; Quercia, Daniele; Iamnitchi, Adriana; Bonchi, Francesco

    2015-01-01

    CQA services are collaborative platforms where users ask and answer questions. We investigate the influence of national culture on people's online questioning and answering behavior. For this, we analyzed a sample of 200 thousand users in Yahoo Answers from 67 countries. We measure empirically a set of cultural metrics defined in Geert Hofstede's cultural dimensions and Robert Levine's Pace of Life and show that behavioral cultural differences exist in community question answering platforms. ...

  18. Asking Questions about Asking Questions in Collaborative Enterprise Modelling

    NARCIS (Netherlands)

    Hoppenbrouwers, Stijn

    2012-01-01

    In this paper we explore the subject of question asking as an inherent driver of enterprise modelling sessions, within the narrower context of the ‘dialogue game’ approach to collaborative modelling. We explain the context, but mostly report on matters directly concerning question asking and answer

  19. And the next question is powerful questions for sticky moments

    CERN Document Server

    Alexander, Rachel

    2012-01-01

    A very practical and easy to use book of 3,000+ powerful questions, forming part of every coach''s / manager''s toolkit; it enables you to easily find key questions in some of the most distinctive areas of coaching, such as confidence, communications & leadership.

  20. Probability and Statistics: 5 Questions

    DEFF Research Database (Denmark)

    Probability and Statistics: 5 Questions is a collection of short interviews based on 5 questions presented to some of the most influential and prominent scholars in probability and statistics. We hear their views on the fields, aims, scopes, the future direction of research and how their work fits...

  1. Asking Research Questions: Theoretical Presuppositions

    Science.gov (United States)

    Tenenberg, Josh

    2014-01-01

    Asking significant research questions is a crucial aspect of building a research foundation in computer science (CS) education. In this article, I argue that the questions that we ask are shaped by internalized theoretical presuppositions about how the social and behavioral worlds operate. And although such presuppositions are essential in making…

  2. Test Pool Questions, Area III.

    Science.gov (United States)

    Sloan, Jamee Reid

    This manual contains multiple choice questions to be used in testing students on nurse training objectives. Each test includes several questions covering each concept. The concepts in section A, medical surgical nursing, are diseases of the following systems: musculoskeletal; central nervous; cardiovascular; gastrointestinal; urinary and male…

  3. The Value Question in Metaphysics.

    Science.gov (United States)

    Kahane, Guy

    2012-07-01

    Much seems to be at stake in metaphysical questions about, for example, God, free will or morality. One thing that could be at stake is the value of the universe we inhabit-how good or bad it is. We can think of competing philosophical positions as describing possibilities, ways the world might turn out to be, and to which value can be assigned. When, for example, people hope that God exists, or fear that we do not possess free will, they express attitudes towards these possibilities, attitudes that presuppose answers to questions about their comparative value. My aim in this paper is to distinguish these evaluative questions from related questions with which they can be confused, to identify structural constraints on their proper pursuit, and to address objections to their very coherence. Answers to such evaluative questions offer one measure of the importance of philosophical disputes.

  4. Questions

    DEFF Research Database (Denmark)

    Larsen, Steen Nepper

    2012-01-01

    Bidrag til festskrift til Jesper Hoffmeyer i anledning af hans 70 års dag i Don Favineau, Paul Cobley & Kalevi Kull (eds.): "A More Developed Sign. Interpreting the Work of Jesper Hoffmeyer". Antologien udg. som særnummer af Tartu Semiotics Library Nr. 10 og mit bidrag forefindes på p. 217-220....

  5. Phrasal Paraphrase Based Question Reformulation for Archived Question Retrieval.

    Directory of Open Access Journals (Sweden)

    Yu Zhang

    Full Text Available Lexical gap in cQA search, resulted by the variability of languages, has been recognized as an important and widespread phenomenon. To address the problem, this paper presents a question reformulation scheme to enhance the question retrieval model by fully exploring the intelligence of paraphrase in phrase-level. It compensates for the existing paraphrasing research in a suitable granularity, which either falls into fine-grained lexical-level or coarse-grained sentence-level. Given a question in natural language, our scheme first detects the involved key-phrases by jointly integrating the corpus-dependent knowledge and question-aware cues. Next, it automatically extracts the paraphrases for each identified key-phrase utilizing multiple online translation engines, and then selects the most relevant reformulations from a large group of question rewrites, which is formed by full permutation and combination of the generated paraphrases. Extensive evaluations on a real world data set demonstrate that our model is able to characterize the complex questions and achieves promising performance as compared to the state-of-the-art methods.

  6. Explaining errors in children's questions.

    Science.gov (United States)

    Rowland, Caroline F

    2007-07-01

    The ability to explain the occurrence of errors in children's speech is an essential component of successful theories of language acquisition. The present study tested some generativist and constructivist predictions about error on the questions produced by ten English-learning children between 2 and 5 years of age. The analyses demonstrated that, as predicted by some generativist theories [e.g. Santelmann, L., Berk, S., Austin, J., Somashekar, S. & Lust. B. (2002). Continuity and development in the acquisition of inversion in yes/no questions: dissociating movement and inflection, Journal of Child Language, 29, 813-842], questions with auxiliary DO attracted higher error rates than those with modal auxiliaries. However, in wh-questions, questions with modals and DO attracted equally high error rates, and these findings could not be explained in terms of problems forming questions with why or negated auxiliaries. It was concluded that the data might be better explained in terms of a constructivist account that suggests that entrenched item-based constructions may be protected from error in children's speech, and that errors occur when children resort to other operations to produce questions [e.g. Dabrowska, E. (2000). From formula to schema: the acquisition of English questions. Cognitive Liguistics, 11, 83-102; Rowland, C. F. & Pine, J. M. (2000). Subject-auxiliary inversion errors and wh-question acquisition: What children do know? Journal of Child Language, 27, 157-181; Tomasello, M. (2003). Constructing a language: A usage-based theory of language acquisition. Cambridge, MA: Harvard University Press]. However, further work on constructivist theory development is required to allow researchers to make predictions about the nature of these operations.

  7. APPROCHES FOR QUESTION ANSWERING SYSTEMS

    Directory of Open Access Journals (Sweden)

    VANITHA GUDA

    2011-02-01

    Full Text Available Question Answering (QA system is a man machine communication device. The basic idea of QA systems in Natural Language Processing (NLP is to provide correct responses to the questions in a human like manner giving short and accurate answers. This paper presents a survey of various types of QA systems. These QA systems are classified as WEBBASED QA system, Information Retrieval or Information Extraction(IR/IEBASED QA system, RESTRICTED DOMAIN QA (RDQA system and RULE BASED QA system. The paper further investigates a comparative study of these models for different type of questioners which led to a breakthrough for new directions of research in this area.

  8. Question Inventory on Tobacco (QIT)

    Data.gov (United States)

    U.S. Department of Health & Human Services — 1965, 1966, 1970, 1974-2015, 2017. Centers for Disease Control and Prevention (CDC). Office on Smoking and Health (OSH). Survey Questions (Tobacco Use). The QIT is...

  9. Solar physics: Dynamo theory questioned

    Science.gov (United States)

    Charbonneau, Paul

    2016-07-01

    Observations of X-ray emission -- a diagnostic tool for the mechanisms driving stellar magnetic fields -- from four cool stars call into question accepted models of magnetic-field generation in the Sun and stars. See Letter p.526

  10. HPV Vaccine - Questions and Answers

    Science.gov (United States)

    ... and Media Resources News Newsletters Events Redirect for HPV Vaccine FAQ Recommend on Facebook Tweet Share Compartir ... to the address below. http://www.cdc.gov/hpv/parents/questions-answers.html File Formats Help: How ...

  11. Winter Weather Frequently Asked Questions

    Science.gov (United States)

    ... Health Matters What's New Preparation & Planning Disasters & Severe Weather Earthquakes Extreme Heat Floods Hurricanes Landslides Tornadoes Tsunamis ... Weather Information on Specific Types of Emergencies Winter Weather Frequently Asked Questions Language: English Español (Spanish) Recommend ...

  12. Birds: Old Questions and New.

    Science.gov (United States)

    Flannery, Maura C.

    2002-01-01

    Discusses questions such as how birds fly and the meaning of bird songs. Explains the relationship between birds and ecological activism and points out the excitement in research and observation of birds. (Contains 34 references.) (YDS)

  13. Question Inventory on Tobacco (QIT)

    Data.gov (United States)

    U.S. Department of Health & Human Services — 1965, 1966, 1970, 1974-2011. Centers for Disease Control and Prevention (CDC). Office on Smoking and Health (OSH). Survey Questions (Tobacco Use). The QIT is a...

  14. Questions and Answers about Stroke

    Science.gov (United States)

    ... Find People About NINDS Questions and Answers About Stroke What is a stroke? A stroke occurs when blood flow to the ... need to function. What are the types of strokes? A stroke can occur in two ways. In ...

  15. Communication and miscommunication of risk: understanding UK parents' attitudes to combined MMR vaccination

    OpenAIRE

    Bellaby, Paul

    2003-01-01

    In this article on the public perception of risks Paul Bellaby considers three examples of risks to children in the UK—an insignificant risk (autism caused by MMR vaccine), a real but probably small risk (vCJD from BSE), and a real and demonstrably larger risk (injuries from road crashes) and contrasts the perceptions of the risks by parents

  16. Key Questions in Thoracic Surgery

    OpenAIRE

    Subotic, Dragan R.

    2016-01-01

    This 1000-page textbook encompasses much more than the title suggests. In fact, the title “Key questions in thoracic surgery and pulmonology” would be more fitting. The specific format of the book, with precise questions and evidence-based, but equally clear answers covering all relevant fields of pulmonology and thoracic surgery, makes this 40-chapter book a “must read” not only for residents, but also for senior pulmonologists and thoracic surgeons.

  17. The Topological Structure of Question Theory

    CERN Document Server

    Nawaz, Shahid

    2010-01-01

    This paper is a self-contained development of the topological structure of question theory. A question is identified with a topology on a given set of irreducible assertions. It is shown that there are three types of a question. Type-I questions generate sub-question, type-II questions have a definite answer and type-III questions are irrelevant. We also suggest that the most efficient machine asks type-II questions.

  18. SOME QUESTIONS CONCERNING PSYCHOANALYTICAL FORMATION

    Directory of Open Access Journals (Sweden)

    Orlando Soeiro Cruxên

    2009-12-01

    Full Text Available The psychoanalytical formation is a question without a definitive answer. The development of its study requests treatment of the evolution of the clinical theory. This work begins with a distinction between analytical and academic formation. It includes Jacques Lacan’s approach concerning the question of psychoanalytical formation. It discusses the relationship between the named intentional and extensional psychoanalysis. This article resumes some theoretical aspects of a post-doctoral investigation developed in the clinical-school of Psychology (Universidade Federal do Ceará e SAP ( Pontifícia Universidade Católica do Rio Grande doSul.

  19. Response times to conceptual questions

    Science.gov (United States)

    Lasry, Nathaniel; Watkins, Jessica; Mazur, Eric; Ibrahim, Ahmed

    2013-09-01

    We measured the time taken by students to respond to individual Force Concept Inventory (FCI) questions. We examine response time differences between correct and incorrect answers, both before and after instruction. We also determine the relation between response time and expressed confidence. Our data reveal three results of interest. First, response times are longer for incorrect answers than for correct ones, indicating that distractors are not automatic choices. Second, response times increase after instruction for both correct and incorrect answers, supporting the notion that instruction changes students' approach to conceptual questions. Third, response times are inversely related to students' expressed confidence; the lower their confidence, the longer it takes to respond.

  20. Ten Practical Questions about Branding

    Science.gov (United States)

    Moore, Robert M.; Rattenbury, Jeanne

    2004-01-01

    "Marketing" and "branding" were once considered dirty words on campus but faculty, staff, and board members now appreciate the value of getting their message out and managing their reputation. The question is not so much whether to invest, but when, how, and most important, what's the return on investment? A roundtable of accomplished marketing…

  1. Open Questions in GRB Physics

    OpenAIRE

    Zhang, Bing

    2011-01-01

    Open questions in GRB physics are summarized as of 2011, including classification, progenitor, central engine, ejecta composition, energy dissipation and particle acceleration mechanism, radiation mechanism, long term engine activity, external shock afterglow physics, origin of high energy emission, and cosmological setting. Prospects of addressing some of these problems with the upcoming Chinese-French GRB mission, SVOM, are outlined.

  2. Education Answers That Vouchers Question.

    Science.gov (United States)

    Sroufe, Gerald E.

    This speech explains education voucher programs and responds to criticisms of such programs. The education voucher system is described as one that questions traditional structures and methods while it equalizes opportunities to purchase education, fosters federally funded and controlled alternative school settings and programs, and gives parents…

  3. Still asking the wrong questions

    DEFF Research Database (Denmark)

    Jensen, Steffen Moltrup Ernø

    by setting up a chase for the heffalump entrepreneur. There has however been a break with this approach. Most commonly referenced is William B. Gartner who presents a critique of the field of entrepreneurship, wherein he questions the general investigative trend of charting the psychological make-up...

  4. Constructivism and Objectivism: Additional Questions

    Science.gov (United States)

    Meltzer, Edmund S.

    2006-01-01

    In past issues of "The Educational Forum," David Elkind (2004; 2005) and Jamin Carson (2005) have engaged in a dialogue about constructivism and objectivism as viable philosophies of education. In this issue, yet another author joins in the discussion by questioning the role of science and religion in objectivism.

  5. [Questions by adolescents about dieting].

    Science.gov (United States)

    Bloch, A

    1989-12-15

    In recent years there has been increasing concern and involvement of Israeli adolescents with dieting. An increase in the incidence of obesity has been emphasized by the mass media. This has been marked by an increase in the number of questions on dieting sent anonymously by 12 to 14 year-olds to a column in a popular youth magazine about adolescent sexuality. These letters include requests for diets to prevent obesity in general and fatness of certain parts of the body in particular, such as the thighs or buttocks; questions as to side-effects of diets already started, particularly amenorrhea; and questions about the onset of bulimia and anorexia nervosa, expressing fear of the consequences. This study gives examples of the questions and the answers, and indicates the professions of those to whom the applicants were referred for further diagnosis and treatment. Newer techniques of health education with regard to adolescent dieting are urgently needed so that the health staff can promote insight and indicate the need for treatment at as early a stage as possible. The use of mass media in a suitable manner is critical, given the increase in diet-advertising. PMID:2620891

  6. Looming Questions in Performance Pay

    Science.gov (United States)

    Gratz, Donald B.

    2010-01-01

    When proposing performance pay for teachers, reformers first must answer three questions: What is the definition of teacher performance? What is the definition of student performance? and What are the goals of schooling? Reformers also need to examine the assumptions that guide their proposals and prepare to deal with the implementation issues…

  7. Arts and Techniques of Questioning

    Institute of Scientific and Technical Information of China (English)

    Sun Yu

    2011-01-01

    Most learners learn English from teachers in classroom. Therefore, classroom instruction plays a very important role. Teachers' questioning constitutes a very significant aspect of classroom teaching. It is not only an important part of classroom interaction but an effective way of learning second language as well.

  8. Understanding Bitcoins: Facts and Questions

    Directory of Open Access Journals (Sweden)

    Bruno Saboia de Albuquerque

    2015-03-01

    Full Text Available The objective of this work is to do a research challenge about the digital currency named Bitcoins, as well as exploit the general concept behind digital currencies and cryptocurrencies, and enumerate some of its current criticism and problems. Such currencies usage and public knowledge is increasing hastily on the last few months, and many questions arise with its popularity.

  9. Common questions in veterinary toxicology.

    Science.gov (United States)

    Bates, N; Rawson-Harris, P; Edwards, N

    2015-05-01

    Toxicology is a vast subject. Animals are exposed to numerous drugs, household products, plants, chemicals, pesticides and venomous animals. In addition to the individual toxicity of the various potential poisons, there is also the question of individual response and, more importantly, of species differences in toxicity. This review serves to address some of the common questions asked when dealing with animals with possible poisoning, providing evidence where available. The role of emetics, activated charcoal and lipid infusion in the management of poisoning in animals, the toxic dose of chocolate, grapes and dried fruit in dogs, the use of antidotes in paracetamol poisoning, timing of antidotal therapy in ethylene glycol toxicosis and whether lilies are toxic to dogs are discussed. PMID:25728477

  10. 222 questions about the energy

    International Nuclear Information System (INIS)

    The book presents with an easy language, questions about energy. The main topics are: - Energy and energy sources - Energy and society - The energy in the world - Basic concepts of Nuclear Physics - Basic concepts of radiological protection - Electric power - Nuclear Fuel cycle - Environmental impact - Radioactive wastes management - The risk in the electricity production - Standardization of Nuclear Safety - Economic aspects of electricity generation - Energy and Spanish economy

  11. Questions as a tool to design

    DEFF Research Database (Denmark)

    Aurisicchio, Marco; Ahmed, Saeema; Wallace, Ken

    2007-01-01

    This paper describes an interpretation of design activity through investigating design questions. From a number of previous studies two types of question have been identified: 1) reasoning questions; and 2) strategic questions. Strategic questions are part of an experienced designers approach to ...

  12. A Reflection on Teacher Questioning Types

    Directory of Open Access Journals (Sweden)

    Kasih Elisabeth Roostini

    2011-07-01

    Full Text Available Abstract This small-scale research is expected to serve as a reflective means for teachers so that they can explore their questioning types in their own classroom. It analyzed questioning types used by three teachers of general English classes. The questioning types were classified based on three dimensions—purpose, form, and function. The purpose-based questioning types, based on Long and Sato’s findings (1983, were classified into two: referential and display. The form-based questioning types, based on the classification of question types by Celce-Murcia and Larsen-Freeman (1999 and Biber et al. (1999, were classified into four major types: yes/no-questions, wh-questions, tag questions, and alternative questions. The function-based questioning types, based on Long and Sato’s findings (1983, were classified into three sub-types: comprehension checks, confirmation checks, and clarification requests.           The data, obtained from three recorded class meetings, were transcribed and analyzed to see what questioning types each teacher employed and to obtain the number and percentage distribution of questioning types each teacher used. The results showed that referential questions were more frequently used than display questions at higher levels. There were a substantial number of incomplete questions, a form-based questioning type that did not belong to the classification of form-based questioning types employed in this study. The predominant use of incomplete questions in a communicative classroom should be reviewed as this questioning type required accuracy, rather than promoting language practice. The third type, the function-based questioning types, did not occur frequently at all the three stages. This study suggests that teachers use incomplete questions less frequently and try to use other form-based questioning types. It also encourages teachers to reflect on their own teaching and pursue their professional development.

  13. God in Question: Questioning as a Prerequisite for Theology

    Directory of Open Access Journals (Sweden)

    Martin Kočí

    2014-10-01

    Full Text Available There are questions that are so important that it is a pity to spoil them with answers. No doubt, the question of God is one of them. Contrary to many presuppositions, theology is not capable of providing us with the final answers in this respect. On the contrary, theology professed as fides quaerens intellectum is an ongoing struggle with questions. Modernity interrupted this paradigm of theological questioning. Theology was withdrawn from the realm of understanding and shifted to the realm of explanation. Modernity brought the univocalization of God. Nonetheless, the attempts to tackle the question of God lead to hegemonic narratives about God. Such narratives are rightly criticized in a postmodern context for their totalizing pretensions. The problem of postmodern criticism is its one-sided emphasis on the apophatic dimension of theological discourse. I propose that theology can go a step further beyond postmodernity. In order to do so, I deal with the Czech philosopher Jan Patočka, who provides an opportunity to rethink God from the perspective of questioning in a new way. Patočka’s insistence on problematicity is the main reading key of his work. In this line of though, I interpret Patočka’s student Tomáš Halík and his thesis about the necessity to take the metaphor of an unknown God into account. I argue that theology must avoid the temptation to remove God from the question and make a well-known God of him. The time has come for theologians to turn their answers back into questions and dwell with them. Bůh jako otázka: Tázání jako předpoklad teologie Některé otázky jsou tak důležité, že je škoda kazit je odpověďmi. Není pochyb, že otázka po Bohu je jednou z nich. Navzdory mnoha předpokladům, ani teologie není schopna poskytnout v tomto ohledu konečné odpovědi. Teologie pojatá jako fides quaerens intellectum je nepřetržitý nekončící zápas s otázkami. Moderna narušila toto paradigma teologick

  14. SIX QUESTIONS IN TEACHING LISTENING

    Institute of Scientific and Technical Information of China (English)

    WangHui

    2004-01-01

    This paper addresses problems common in the listening classes, namely, lack of motivation, orientation and sense of achievement and the presence of pressure, fear and frustration. The author examines different factors in the teaching of listening and poses 6 questions that might help teachers to reflect on their teaching. The conclusion is that the aim of listening class is to develop rather than test listening strategies and skills; that students need to be provided with communicative tasks before and while listening; that materials should be realistic, varied and graded ; that listening should be integrated with other skills development; and finally, that learner autonomy provides the ultimate solution to listening problems.

  15. Open forum: Question and responses

    International Nuclear Information System (INIS)

    The question addressed in this section is: With the end of the Cold War and the exchange of information improving between East and West, what roles should government agencies and non-government organizations from developed countries play in assisting less developed countries in developing a stronger environmental protection program? Responses presented here were obtained from Richard H. Schulze (President of Trinity Consultants, Inc.), Sagar Krupa (Professor, Department of Plant Pathology, University of Minnesota), and Thomas T. Shen (Ph.D., D.AAEE, Retiree of the New York Department of Environmental Conservation)

  16. Ten questions about systems biology

    DEFF Research Database (Denmark)

    Joyner, Michael J; Pedersen, Bente K

    2011-01-01

    In this paper we raise 'ten questions' broadly related to 'omics', the term systems biology, and why the new biology has failed to deliver major therapeutic advances for many common diseases, especially diabetes and cardiovascular disease. We argue that a fundamentally narrow and reductionist...... to understand how whole animals adapt to the real world. We argue that a lack of fluency in these concepts is a major stumbling block for what has been narrowly defined as 'systems biology' by some of its leading advocates. We also point out that it is a failure of regulation at multiple levels that causes many...

  17. Biology Question Generation from a Semantic Network

    Science.gov (United States)

    Zhang, Lishan

    Science instructors need questions for use in exams, homework assignments, class discussions, reviews, and other instructional activities. Textbooks never have enough questions, so instructors must find them from other sources or generate their own questions. In order to supply instructors with biology questions, a semantic network approach was developed for generating open response biology questions. The generated questions were compared to professional authorized questions. To boost students' learning experience, adaptive selection was built on the generated questions. Bayesian Knowledge Tracing was used as embedded assessment of the student's current competence so that a suitable question could be selected based on the student's previous performance. A between-subjects experiment with 42 participants was performed, where half of the participants studied with adaptive selected questions and the rest studied with mal-adaptive order of questions. Both groups significantly improved their test scores, and the participants in adaptive group registered larger learning gains than participants in the control group. To explore the possibility of generating rich instructional feedback for machine-generated questions, a question-paragraph mapping task was identified. Given a set of questions and a list of paragraphs for a textbook, the goal of the task was to map the related paragraphs to each question. An algorithm was developed whose performance was comparable to human annotators. A multiple-choice question with high quality distractors (incorrect answers) can be pedagogically valuable as well as being much easier to grade than open-response questions. Thus, an algorithm was developed to generate good distractors for multiple-choice questions. The machine-generated multiple-choice questions were compared to human-generated questions in terms of three measures: question difficulty, question discrimination and distractor usefulness. By recruiting 200 participants from

  18. No question about exciting questions in cell biology.

    Directory of Open Access Journals (Sweden)

    Thomas D Pollard

    2013-12-01

    Full Text Available Although we have a good grasp of many important processes in cell biology, including knowledge of many molecules involved and how they interact with each other, we still do not understand most of the dynamical features that are the essence of living systems. Fortunately, we now have the ability to dissect biological systems in enough detail to understand their dynamics, including the use of mathematical models to account for past observations and predict future experiments. This deep level of mechanistic understanding should be our goal—not simply to satisfy our scientific curiosity, but also to understand the causes of disease well enough to predict risks, make early diagnoses, and treat effectively. Many big questions remain to be answered before we reach this goal of understanding cellular dynamics.

  19. No question about exciting questions in cell biology.

    Science.gov (United States)

    Pollard, Thomas D

    2013-12-01

    Although we have a good grasp of many important processes in cell biology, including knowledge of many molecules involved and how they interact with each other, we still do not understand most of the dynamical features that are the essence of living systems. Fortunately, we now have the ability to dissect biological systems in enough detail to understand their dynamics, including the use of mathematical models to account for past observations and predict future experiments. This deep level of mechanistic understanding should be our goal—not simply to satisfy our scientific curiosity, but also to understand the causes of disease well enough to predict risks, make early diagnoses, and treat effectively. Many big questions remain to be answered before we reach this goal of understanding cellular dynamics.

  20. Are Quantum Theory Questions Epistemic?

    Directory of Open Access Journals (Sweden)

    Viviana Yaccuzzi Polisena

    2013-12-01

    Full Text Available How to displace-move quantum theory [Ǭ] questions-problems to philosophy? Seeing the collapse of our society’s cultural-intellectual-morals, the philosophy of the 21st century has to contribute to the formation of new principles-formalisms: the big task of the contemporary philosophy ©] is to innovate, to transform the building of the knowledge! Which is the role of the contemporary philosopher? (Noam Chomsky. Building science so that it is more human, out of the scientific mercantilism so that it does not continue transgressing that which is most precious: the thought-life. The ideas that I propose demand a deep cultural-epistemiologicscientific-philosophical-ethical rethinking that goes from quantum entities up to life in society. The starting idea is «the quantum [Ǭ], the paradigm of the contemporary science ©]» (Bernard D’Espagnat. I propose to displace-move questions of the quantum theory [Ǭ]: spin, measure, layering to the field of philosophy (φ to build generic symbols. Can the contemporary episteme model the collapse of the ? For a philosopher, can understanding the importance and the behaviour of the spin bring something new to philosophy ? Can information of the states of the spin be used to observe in a holographic way the pattern energy-information contained in the quantum entities? Is quantum [Ǭ] physics mechanical?

  1. Evaluative Conditioning: The "How" Question.

    Science.gov (United States)

    Jones, Christopher R; Olson, Michael A; Fazio, Russell H

    2010-01-01

    Evaluative conditioning (EC) refers to attitude formation or change toward an object due to that object's mere co-occurrence with another valenced object or objects. This chapter focuses on the "how" question, that is, the question of what cognitive processes intervene between mere co-occurrence and attitude formation or change. Though EC has typically been thought of as occurring through a single, albeit contentious, mechanism, we begin by pointing out that both the heterogeneity of EC methodologies and the abundance of inconsistent results suggest that multiple processes with different characteristics can produce EC. We describe how the earliest posited process of EC, Pavlovian conditioning or signal learning, is a valid mechanism of EC that appears to have operated in some experiments but is unlikely to have operated in others and also cannot account for various EC findings. We describe other mechanisms of EC, when they can be expected to occur, and what characteristics they have. We particularly focus our attention on a process model of EC we have recently introduced, the implicit misattribution model. Finally, we describe the implications of a multi-process view of EC, which we argue can help resolve theoretical controversies and further the application of EC as a practical intervention for influencing attitudes in various domains.

  2. [The questions of international migration].

    Science.gov (United States)

    Samman, M L

    1993-03-01

    International migrations have growing implications for both countries of destination. In the latter, the presence of foreigners and of members of their families today creates problems of integration, causes argument, and brings mounting xenophobia. Paralleling political, economic, and social measures taken by public authorities to respond to these difficulties, education needs to assist in diffusing the resulting social tensions by preparing the minds of learners and helping to develop new attitudes. In particular, when educational programs address questions of international migration, these should be treated in the framework of historical evolution in order that their real significance and their true temporal and spatial dimensions become apparent. It is also important that the growing interdependence between countries should be made plain, that national history should be placed in its international context, and that the true consequences of these developments should be made clear. In this context, learners need to be acquainted with Human Rights, thereby stressing universal moral values and the role of the individual. Lastly, questions relating to international migration are usually presented in the media in a selective and partial manner, and the young people who take in this information often accept the hasty judgments which are made of situations as proven facts. This is why all teaching about international migration needs to be considered or reconsidered in light of the complementary or competing actions of the media. (author's modified) PMID:12286405

  3. Les questions de migrations internationales

    Science.gov (United States)

    Samman, Mouna Liliane

    1993-03-01

    International migrations have growing implications for both countries of origin and countries of destination. In the latter, the presence of foreigners and of members of their families today creates problems of integration, causes argument and brings mounting xenophobia. Paralleling political, economic and social measures taken by public authorities to respond to these difficulties, education needs to assist in defusing the resulting social tensions by preparing the minds of learners and helping to develop new attitudes. In particular, when educational programmes address questions of international migration, these should be treated in the framework of historical evolution so that their real significance and their true temporal and spatial dimensions become apparent. It is also important that the growing interdependence between countries should be made plain, that national history should be placed in its international context, and that the true consequences of these developments should be made clear. In this context, learners need to be acquainted with Human Rights, thereby stressing universal moral values and the role of the individual. Lastly, questions relating to international migration are usually presented in the media in a selective and partial manner, and the young people who take in this information often accept the hasty judgments which are made of situations as proven facts. This is why all teaching about international migration needs to be considered or reconsidered in the light of the complementary or competing actions of the media.

  4. Questioning Strategy in English Teaching

    Institute of Scientific and Technical Information of China (English)

    李顺梅

    2015-01-01

    Learner autonomy has been a hot issue discussed by educators in recent years.Because it is believed that the ulti-mate goal of educating is to help students learn autonomously and actively not only in school but also,after graduation,for their whole life.Many people misunderstand the meaning of learner autonomy as learners learn something totally independent from teacher or learn after class.This is not the truth;teacher is indispensible to promote learner autonomy.Therefore,English teacher bears a great respon-sibility of fostering and promoting learner autonomy in the classroom.Questioning is the most frequently used and easiest method in the various teaching methods.

  5. Ten questions about systems biology

    DEFF Research Database (Denmark)

    Joyner, Michael J; Pedersen, Bente K

    2011-01-01

    In this paper we raise 'ten questions' broadly related to 'omics', the term systems biology, and why the new biology has failed to deliver major therapeutic advances for many common diseases, especially diabetes and cardiovascular disease. We argue that a fundamentally narrow and reductionist...... perspective about the contribution of genes and genetic variants to disease is a key reason 'omics' has failed to deliver the anticipated breakthroughs. We then point out the critical utility of key concepts from physiology like homeostasis, regulated systems and redundancy as major intellectual tools...... to understand how whole animals adapt to the real world. We argue that a lack of fluency in these concepts is a major stumbling block for what has been narrowly defined as 'systems biology' by some of its leading advocates. We also point out that it is a failure of regulation at multiple levels that causes many...

  6. On Effective Questioning in English Classes

    Institute of Scientific and Technical Information of China (English)

    夏慧芳

    2010-01-01

    Teachers' questioning has traditionally been viewed as an important constituent of teacher talk and the core of effective teaching in classroom context.Questioning is the basic means used by teachers to challenge students to think,appraise teaching results and help students to realize their desired goals,thus,playing a key role in the second language acquisition.This paper will first introduce the definition and types of teachers'questioning and the criteria for effective questioning.It will also give some practical suggestions for practice effective questioning,focusing on good questions,wait-time,feedback and allocation of questions.

  7. Socrates' questions: a focus for nursing.

    Science.gov (United States)

    Bunkers, Sandra S

    2004-07-01

    This column focuses on the philosophical dialogue originated by Socrates. Six questions that Socrates would ask the ancient Greeks are explored in discussing a book written by Phillips entitled Six Questions of Socrates. These questions were: What is virtue? What is moderation? What is justice? What is good? What is courage? What is piety? A human becoming perspective is used as a lens to view the discussion on these questions and the question is posed, "What would it be like to frame discussions on health and quality of life around Socrates' questions?" Parse's teaching-learning processes are presented as a means of creating an environment where dialogue on these questions can occur.

  8. Questions Cooperative Directors Should Be Asking Management

    OpenAIRE

    Anderson, Bruce L.; Henehan, Brian M.

    2002-01-01

    The most important responsibility of cooperative directors is to JUDICIOUSLY ASK THE RIGHT QUESTIONS OF MANAGEMENT. It has been suggested that some directors do not know all of the correct questions to ask of management, or how. The purpose of this paper is fourfold: 1) To briefly describe how directors should pose questions to management, 2) To provide an extensive list of questions directors should know the answers to, 3) To outline a generic format for asking general questions and 4) To as...

  9. Questioning and critical thinking in liberal studies

    OpenAIRE

    Hang, Wing-sum; 幸穎沁

    2014-01-01

    The present study examines the relations between questioning and critical thinking in Liberal Studies. In particular, it introduces the use of Questioning Cycle to investigate the effectiveness of questioning in cultivating students’ critical thinking skills and dispositions. By identifying difficulties and constrains in teaching critical thinking, it is hope to offer insights to improving questioning skills, in hope of developing questioning as an effective teaching strategy in Liberal Studi...

  10. Frequently Asked Questions: The Higgs!

    CERN Multimedia

    CERN Bulletin

    2012-01-01

    Why have we tried so hard to find the Higgs particle? How does the Higgs mechanism work? What is the difference in physics between strong evidence and a discovery? Why do physicists speak in terms of "sigmas"? Find out here!   Why have we tried so hard to find the Higgs particle? Because it could be the answer to the question: how does Nature decide whether or not to assign mass to particles? All the fundamental particles making up matter – the electron, the quarks, etc. – have masses. Moreover, quantum physics requires that forces are also carried by particles. The W and Z particles that carry the weak force responsible for radioactivity must also have masses, whereas the photon, the carrier of the electromagnetic force, has no mass at all. This is the root of the “Higgs problem”: how to give masses to the fundamental particles and break the symmetry between the massive W and Z and the massless photon? Just assigning masses by hand...

  11. Generalized cerebral atrophy seen on MRI in a naturally exposed animal model for creutzfeldt-jakob disease

    Directory of Open Access Journals (Sweden)

    Dasanu Constantin A

    2010-11-01

    Full Text Available Abstract Background Magnetic resonance imaging has been used in the diagnosis of human prion diseases such as sCJD and vCJD, but patients are scanned only when clinical signs appear, often at the late stage of disease. This study attempts to answer the questions "Could MRI detect prion diseases before clinical symptoms appear?, and if so, with what confidence?" Methods Scrapie, the prion disease of sheep, was chosen for the study because sheep can fit into a human sized MRI scanner (and there were no large animal MRI scanners at the time of this study, and because the USDA had, at the time of the study, a sizeable sample of scrapie exposed sheep, which we were able to use for this purpose. 111 genetically susceptible sheep that were naturally exposed to scrapie were used in this study. Results Our MRI findings revealed no clear, consistent hyperintense or hypointense signal changes in the brain on either clinically affected or asymptomatic positive animals on any sequence. However, in all 37 PrPSc positive sheep (28 asymptomatic and 9 symptomatic, there was a greater ventricle to cerebrum area ratio on MRI compared to 74 PrPSc negative sheep from the scrapie exposed flock and 6 control sheep from certified scrapie free flocks as defined by immunohistochemistry (IHC. Conclusions Our findings indicate that MRI imaging can detect diffuse cerebral atrophy in asymptomatic and symptomatic sheep infected with scrapie. Nine of these 37 positive sheep, including 2 one-year old animals, were PrPSc positive only in lymph tissues but PrPSc negative in the brain. This suggests either 1 that the cerebral atrophy/neuronal loss is not directly related to the accumulation of PrPSc within the brain or 2 that the amount of PrPSc in the brain is below the detectable limits of the utilized immunohistochemistry assay. The significance of these findings remains to be confirmed in human subjects with CJD.

  12. Questions That This Monograph Raises

    Directory of Open Access Journals (Sweden)

    Editors

    2007-01-01

    Full Text Available What is the ideal combination of increased investment in biomedical research by sponsors with least conflict of interest in researchers?What should interested parties do to refurbish pharma's image?Is a voluntary moratorium on pharma spending practically possible?How to resolve the basic schism between profit driven industry and welfare driven profession of medicine?How can CPGs be salvaged from ulterior influence?Can guidelines on guidelines help?Is cost-effectiveness of CPGs a practical solution?Is it possible to grade therapies as Most, Moderate and Least Cost Effective?How can Disease specific Foundations be salvaged from sponsor's influence?How can Journals ensure scientific integrity of conflicted authors and nullify untoward influence of sponsors?Are reports like the Task Force on individual and institutional conflicts of interest of the AAMC followed more in their breach?Are the revised ICMJE guidelines adequate to stub conflicted research?Editorials make pious announcements. Do they really influence what researchers do?How do we protect the interests of human research subjects?Do Best Practice Guidelines and Good Publication Practices really help?Marketability is the name of the game, not usefulness. How do we ensure the latter, even as the former is forwarded?How can we ensure effective traditional therapies remain in use even as new ones are forwarded?How do we ensure non-pharmacological therapies are also forwarded?How can the legitimate thrust of biological psychiatry be encouraged while also forwarding non-pharmacological approaches in psychiatry?What can be done so pharma just cannot consider questionable means as an attractive alternative?How do we expedite scientific self-correction while causing least harm to patients and research subjects?

  13. A Technique Socratic Questioning-Guided Discovery

    Directory of Open Access Journals (Sweden)

    M. Hakan Türkçapar

    2012-03-01

    Full Text Available “Socratic Method” is a way of teaching philosophical thinking and knowledge by asking questions which was used by antique period greek philosopher Socrates. Socrates was teaching knowledge to his followers by asking questions and the conversation between them was named “Socratic Dialogues”. In this meaning, no novel knowledge is taught to the individual but only what is formerly known is reminded and rediscovered. The form of socratic questioning which is used during the process of cognitive behavioral therapy is known as Guided Discovery. In this method it is aimed to make the client notice the piece of knowledge which he could notice but is not aware with a series of questions. Socratic method or guided discovery consists of several steps which are: Identifying the problem by listening to the client and making reflections, finding alternatives by examining and evaluating, reidentification by using the newly found information and questioning the old distorted belief and reaching to a conclusion and applying it. Question types used during these procedures are, questions for gaining information, questions revealing the meanings, questions revealing the beliefs, questions about behaviours during the similar past experiences, analyse questions and analytic synthesis questions. In order to make the patient feel understood it is important to be empathetic and summarising the problem during the interview. In this text, steps of Socratic Questioning-Guided Discovery will be reviewed with sample dialogues after each step

  14. Provocative Questions in Cancer: NCI Seminar

    Science.gov (United States)

    science writers' seminar to discuss various aspects of one of NCI’s signature efforts -- the Provocative Questions project. Discussion will focus on the scientific research that surrounds some of these questions.

  15. Evaluating Multilingual Question Answering Systems at CLEF

    OpenAIRE

    Forner, Pamela; Giampiccolo, Danilo; Magnini, Bernardo; Peñas, Anselmo; Rodrigo, Álvaro; Sutcliffe, Richard

    2010-01-01

    The paper offers an overview of the key issues raised during the seven years’ activity of the Multilingual Question Answering Track at the Cross Language Evaluation Forum (CLEF). The general aim of the Multilingual Question Answering Track has been to

  16. Heart Failure Questions to Ask Your Doctor

    Science.gov (United States)

    ... Stroke More Heart Failure Questions to Ask Your Doctor Updated:Mar 25,2016 These are concerns that ... draw up a list of questions for your physician or healthcare team. Download Partnering in Your HF ...

  17. Climate Change Facts: Answers to Common Questions

    Science.gov (United States)

    ... Basics Climate Change Facts: Answers to Common Questions Climate Change Facts: Answers to Common Questions This page ... All Responses Is there a scientific consensus on climate change? The major scientific agencies of the United ...

  18. FVQA: Fact-based Visual Question Answering

    OpenAIRE

    Wang, Peng; Wu, Qi; Shen, Chunhua; Hengel, Anton van den; Dick, Anthony

    2016-01-01

    Visual Question Answering (VQA) has attracted a lot of attention in both Computer Vision and Natural Language Processing communities, not least because it off?ers insight into the relationships between two important sources of information. Current datasets, and the models built upon them, have focused on questions which are answerable by direct analysis of the question and image alone. The set of such questions that require no external information to answer is interesting, but very limited. I...

  19. Testing Programming Skills with Multiple Choice Questions

    OpenAIRE

    Clark, David

    2004-01-01

    Multiple choice questions are a convenient and popular means of testing beginning students in programming courses. However, they are qualitatively different from exam questions. This paper reports on a study into which types of multiple choice programming questions discriminate well on a final exam, and how well they predict exam scores.

  20. Questions and Answers About Nuclear Power Plants.

    Science.gov (United States)

    Environmental Protection Agency, Washington, DC.

    This pamphlet is designed to answer many of the questions that have arisen about nuclear power plants and the environment. It is organized into a question and answer format, with the questions taken from those most often asked by the public. Topics include regulation of nuclear power sources, potential dangers to people's health, whether nuclear…

  1. IMS Learning Design Frequently Asked Questions

    NARCIS (Netherlands)

    Tattersall, Colin; Manderveld, Jocelyn; Hummel, Hans; Sloep, Peter; Koper, Rob; De Vries, Fred

    2004-01-01

    This list of frequently asked questions was composed on the basis of questions asked of the Educational Technology Expertise Centrum. The questions addessed are: Where can I find the IMS Learning Design Specification? What is meant by the phrase “Learning Design”? What is the IMS LD Specification ab

  2. Questions That Science Teachers Find Difficult (II).

    Science.gov (United States)

    Goodwin, Alan

    2003-01-01

    Presents some questions that science teachers find difficult. Focuses on three further questions relating to "simple" everyday situations that are normally explained in terms of the kinetic theory of matter. Identifies looking at the difference between chemical and physical changes as the most problematic question. (Author/YDS)

  3. Good Student Questions in Inquiry Learning

    Science.gov (United States)

    Lombard, François E.; Schneider, Daniel K.

    2013-01-01

    Acquisition of scientific reasoning is one of the big challenges in education. A popular educational strategy advocated for acquiring deep knowledge is inquiry-based learning, which is driven by emerging "good questions". This study will address the question: "Which design features allow learners to refine questions while preserving…

  4. Teaching Students to Form Effective Questions

    Science.gov (United States)

    Stafford, Tish

    2009-01-01

    The ability to question lies at the heart of human curiosity and is a necessary component of cognition. The author stresses that forming questions is essential to human thought and communication. As such, forming questions is a foundational process that cuts across curricular areas and is embedded in content standards across the nation, including…

  5. Heidegger and Derrida on the Nature of Questioning: Towards the Rehabilitation of Questioning in Contemporary Philosophy

    NARCIS (Netherlands)

    Blok, V.

    2015-01-01

    In this article, the Heidegger and Derrida controversy about the nature of questioning is revisited in order to rehabilitate questioning as an essential characteristic of contemporary philosophy. After exploring Heidegger's characterization of philosophy as questioning and Derrida's criticism of the

  6. Art of Question in English Teaching

    Institute of Scientific and Technical Information of China (English)

    韩雪

    2009-01-01

    A language is the tool of human communication. English teaching is really not a way to input or output information-it is not an one-way transmission of information. Students must personally think, speak and write what they are taught. That is the practical features of English teaching. Questioning is one of important methods which embody this feature completely. Teachers apply asking questions to enlighten and stimulate students in order to perfect this vital importance. Students who are in middle schools are asked questions but do not give answers. Except for learners' own quality and degree of difficulty of questions, it is connected with teachers' quality of asking questions.

  7. Automatic Question Answering from Web Documents

    Institute of Scientific and Technical Information of China (English)

    LI Xin; HU Dawei; LI Huan; HAO Tianyong; CHEN Enhong; LIU Wenyin

    2007-01-01

    A passage retrieval strategy for web-based question answering (QA) systems is proposed in our QA system. It firstly analyzes the question based on semantic patterns to obtain its syntactic and semantic information and then form initial queries. The queries are used to retrieve documents from the World Wide Web (WWW) using the Google search engine. The queries are then rewritten to form queries for passage retrieval in order to improve the precision. The relations between keywords in the question are employed in our query rewrite method. The experimental result on the question set of the TREC-2003 passage task shows that our system performs well for factoid questions.

  8. Approaches to Exploring Category Information for Question Retrieval in Community Question-Answer Archives

    DEFF Research Database (Denmark)

    Cao, Xin; Cong, Gao; Cui, Bin;

    2012-01-01

    Community Question Answering (CQA) is a popular type of service where users ask questions and where answers are obtained from other users or from historical question-answer pairs. CQA archives contain large volumes of questions organized into a hierarchy of categories. As an essential function of...... CQA services, question retrieval in a CQA archive aims to retrieve historical question-answer pairs that are relevant to a query question. This article presents several new approaches to exploiting the category information of questions for improving the performance of question retrieval, and it...... applies these approaches to existing question retrieval models, including a state-of-the-art question retrieval model. Experiments conducted on real CQA data demonstrate that the proposed techniques are effective and efficient and are capable of outperforming a variety of baseline methods significantly...

  9. 150 Student Questions on Solar Physics

    Science.gov (United States)

    Lopez, R. E.; Gross, N. A.; Knipp, D. J.

    2010-12-01

    The Center for Integrated Space Weather Modeling (CISM) holds a two-week Space Weather Summer School for introductory graduate students and space weather professionals to gain a system level understanding of the space environment and the effects of space weather. A typical day in the summer school consists of three morning lectures followed by an afternoon lab session. After the morning lectures, the participants are each asked to submit a question about the mornings topics on a question card. The lecturers then take the time to answer these questions prior to afternoon sessions. In the last 5 years over 1000 such question cards have been collected and cataloged. Despite detailed lectures by experts similar questions appear every year. We have analyzed over 150 questions related to the introductory lectures on solar physics and solar activity. Questions content was categorized using the AGU Index, and question sophistication was categorized using Bloom’s Taxonomy of Educational Objectives. Specific analysis results along with lists of questions will be presented. We hope that these results can be used to improve the lecture and classroom content and allow students to move beyond low level education objectives and ask more sophisticated questions.

  10. Question Classification Taxonomies as Guides to Formulating Questions for Use in Chemistry Classrooms

    Science.gov (United States)

    Festo, Kayima

    2016-01-01

    Teacher questions play an important role in facilitating classroom discourse. Using appropriate question types and proper questioning techniques help to create reflective-active learners. Teacher questions can elicit students' explanations, elaboration of their ideas and thinking, and they can be used to disclose students' misconceptions. Despite…

  11. Why Usual Assumptions Should be Questioned ?

    OpenAIRE

    Godfroy, Anne-Sophie

    2011-01-01

    Even if usual hypotheses in gender and science research are well established and useful, we want to question some of them in order to move towards new more complex and qualitative research questions and deepen the existing knowledge in this field. In this paper, we propose to question five issues in an exploratory way: the proportion of female students in relation to cultural change, the impact of role models on female recruitment, the work-life balance issue in relation to attractiveness and...

  12. Engineering a Testbank of Engineering Questions

    OpenAIRE

    Davis, HC; White, SA; Dickens, KP

    2002-01-01

    e3an is a collaborative UK project developing a network of expertise in assessment issues within electrical and electronic engineering. A major focus is the development of a testbank of peer-reviewed questions for diagnostic, formative and summative assessment. The resulting testbank will contain thousands of well-constructed and tested questions and answers. Question types include objective, numeric, short answer and examination. Initially a set of metadata descriptors were specified classif...

  13. "Wh"-Questions in the English Language

    Science.gov (United States)

    Mowarin, Macaulay

    2011-01-01

    This paper analyzes "wh"-questions in the English Language based mainly on Chomsky's Minimalist Programme of transformational grammar as the theoretical model. The four main objectives of this paper are as follows: first, it undertakes a cross linguistic typological analysis of "wh"-questions and it then discusses the derivation of…

  14. The ecological crisis: a question of justice

    International Nuclear Information System (INIS)

    The question of ecology has become a major issue for international relations in the next half-century. But it poses new problems of worldwide justice more than questions of power politics, and its solution will always be a reflection of internal social issues in the countries concerned. (author)

  15. 29 CFR 18.104 - Preliminary questions.

    Science.gov (United States)

    2010-07-01

    ... OF ADMINISTRATIVE LAW JUDGES Rules of Evidence § 18.104 Preliminary questions. (a) Questions of... existence of a privilege, or the admissibility of evidence shall be determined by the judge, subject to the... of evidence except those with respect to privileges. (b) Relevance conditioned on fact. When...

  16. Risk Factor Analysis and the Youth Question

    Science.gov (United States)

    France, Alan

    2008-01-01

    This paper is concerned with exploring how in late modernity the "youth question" is being addressed by public policy and what impact this is having on understandings of childhood and youth. Historically the youth question has been shaped by adult anxieties over youth delinquency and their problems of social integration. In late modernity, this is…

  17. Questioning Techniques: A Study of Instructional Practice

    Science.gov (United States)

    Hill, Joan Buchanan

    2012-01-01

    This study took place in an independent all girls' school which serves over six hundred students in grades pre-kindergarten through twelve. This study seeks to answer the question: To what extent do teachers use questions to encourage deeper thinking and fuller responses. Through a review of literature, observations, interviews and analysis,…

  18. 32 CFR 287.10 - Questions.

    Science.gov (United States)

    2010-07-01

    ... INFORMATION ACT PROGRAM DEFENSE INFORMATION SYSTEMS AGENCY FREEDOM OF INFORMATION ACT PROGRAM § 287.10 Questions. Questions on both the substance and procedures of the FOIA and the DISA implementation thereof..., faxes, and electronic mail. FOIA requests should be addressed as follows: Defense Information...

  19. Fixed-Response Questions with a Difference.

    Science.gov (United States)

    Johnstone, Alex H.; Ambusaidi, Abdullah

    2002-01-01

    Offers three types of fixed-response questions that are designed to overcome drawbacks appearing in the conventional forms of fixed-response questions such as not allowing the examiner to investigate reasoning, background, or prevent guessing. (Contains 14 references.) (Author/YDS)

  20. Semantic Question Generation Using Artificial Immunity

    Directory of Open Access Journals (Sweden)

    Ibrahim E. Fattoh

    2015-01-01

    Full Text Available This research proposes an automatic question generation model for evaluating the understanding of semantic attributes in a sentence. The Semantic Role Labeling and Named Entity Recognition are used as a preprocessing step to convert the input sentence into a semantic pattern. The Artificial Immune System is used to build a classifier that will be able to classify the patterns according to the question type in the training phase. The question types considered here are the set of WH-questions like who, when, where, why, and how. A pattern matching phase is applied for selecting the best matching question pattern for the test sentence. The proposed model is tested against a set of sentences obtained from many sources such as the TREC 2007 dataset for question answering, Wikipedia articles, and English book of grade II preparatory. The experimental results of the proposed model are promising in determining the question type with classification accuracy reaching 95%, and 87% in generating the new question patterns.

  1. Mental Models of Research: Generating Authentic Questions

    Science.gov (United States)

    Donham, Jean; Heinrich, Jill A.; Bostwick, Kerry A.

    2010-01-01

    In this paper, we question how we might disrupt positivist research paradigms that preclude students from engaging and experiencing ownership in the research process. We question what we, as professors, could do to facilitate the transition from traditional research reporting to a disposition of inquiry that allows for ambiguity and discovery in…

  2. Doing Science and Asking Questions II: An Exercise That Generates Questions

    Science.gov (United States)

    Hurt Middlecamp, Catherine; Nickel, Anne-Marie L.

    2005-08-01

    Given the importance of questions in science, it is critical that students learn to ask questions as well as learning to answer them. This paper describes a classroom exercise to help students better ask their own questions. It has been classroom-tested in multiple formats and has also been used for curriculum development workshops for faculty. This exercise in creating questions can be easily customized to suit different instructional contexts; some variations are outlined. More broadly, this paper also discusses the pedagogical significance of questioning, raising four salient points: (1) learners are more likely to have a personal interest in the questions they raise; (2) questions can serve as entry points for issues relating to ethnicity and gender; (3) questions give control to the person who asks them; and (4) questions can challenge existing structures, categories, and norms.

  3. Red-backed vole brain promotes highly efficient in vitro amplification of abnormal prion protein from macaque and human brains infected with variant Creutzfeldt-Jakob disease agent.

    Science.gov (United States)

    Nemecek, Julie; Nag, Nabanita; Carlson, Christina M.; Schneider, Jay R.; Heisey, Dennis M.; Johnson, Christopher J.; Asher, David M.; Gregori, Luisa

    2013-01-01

    Rapid antemortem tests to detect individuals with transmissible spongiform encephalopathies (TSE) would contribute to public health. We investigated a technique known as protein misfolding cyclic amplification (PMCA) to amplify abnormal prion protein (PrPTSE) from highly diluted variant Creutzfeldt-Jakob disease (vCJD)-infected human and macaque brain homogenates, seeking to improve the rapid detection of PrPTSE in tissues and blood. Macaque vCJD PrPTSE did not amplify using normal macaque brain homogenate as substrate (intraspecies PMCA). Next, we tested interspecies PMCA with normal brain homogenate of the southern red-backed vole (RBV), a close relative of the bank vole, seeded with macaque vCJD PrPTSE. The RBV has a natural polymorphism at residue 170 of the PrP-encoding gene (N/N, S/S, and S/N). We investigated the effect of this polymorphism on amplification of human and macaque vCJD PrPTSE. Meadow vole brain (170N/N PrP genotype) was also included in the panel of substrates tested. Both humans and macaques have the same 170S/S PrP genotype. Macaque PrPTSE was best amplified with RBV 170S/S brain, although 170N/N and 170S/N were also competent substrates, while meadow vole brain was a poor substrate. In contrast, human PrPTSE demonstrated a striking narrow selectivity for PMCA substrate and was successfully amplified only with RBV 170S/S brain. These observations suggest that macaque PrPTSE was more permissive than human PrPTSE in selecting the competent RBV substrate. RBV 170S/S brain was used to assess the sensitivity of PMCA with PrPTSE from brains of humans and macaques with vCJD. PrPTSE signals were reproducibly detected by Western blot in dilutions through 10-12 of vCJD-infected 10% brain homogenates. This is the first report showing PrPTSE from vCJD-infected human and macaque brains efficiently amplified with RBV brain as the substrate. Based on our estimates, PMCA showed a sensitivity that might be sufficient to detect PrPTSE in vCJD

  4. Red-backed vole brain promotes highly efficient in vitro amplification of abnormal prion protein from macaque and human brains infected with variant Creutzfeldt-Jakob disease agent.

    Directory of Open Access Journals (Sweden)

    Julie Nemecek

    Full Text Available Rapid antemortem tests to detect individuals with transmissible spongiform encephalopathies (TSE would contribute to public health. We investigated a technique known as protein misfolding cyclic amplification (PMCA to amplify abnormal prion protein (PrP(TSE from highly diluted variant Creutzfeldt-Jakob disease (vCJD-infected human and macaque brain homogenates, seeking to improve the rapid detection of PrP(TSE in tissues and blood. Macaque vCJD PrP(TSE did not amplify using normal macaque brain homogenate as substrate (intraspecies PMCA. Next, we tested interspecies PMCA with normal brain homogenate of the southern red-backed vole (RBV, a close relative of the bank vole, seeded with macaque vCJD PrP(TSE. The RBV has a natural polymorphism at residue 170 of the PrP-encoding gene (N/N, S/S, and S/N. We investigated the effect of this polymorphism on amplification of human and macaque vCJD PrP(TSE. Meadow vole brain (170N/N PrP genotype was also included in the panel of substrates tested. Both humans and macaques have the same 170S/S PrP genotype. Macaque PrP(TSE was best amplified with RBV 170S/S brain, although 170N/N and 170S/N were also competent substrates, while meadow vole brain was a poor substrate. In contrast, human PrP(TSE demonstrated a striking narrow selectivity for PMCA substrate and was successfully amplified only with RBV 170S/S brain. These observations suggest that macaque PrP(TSE was more permissive than human PrP(TSE in selecting the competent RBV substrate. RBV 170S/S brain was used to assess the sensitivity of PMCA with PrP(TSE from brains of humans and macaques with vCJD. PrP(TSE signals were reproducibly detected by Western blot in dilutions through 10⁻¹² of vCJD-infected 10% brain homogenates. This is the first report showing PrP(TSE from vCJD-infected human and macaque brains efficiently amplified with RBV brain as the substrate. Based on our estimates, PMCA showed a sensitivity that might be sufficient to detect Pr

  5. Clinical Issues-May 2016.

    Science.gov (United States)

    Van Wicklin, Sharon A

    2016-05-01

    Variations in documenting surgical wound classification Key words: surgical wound classification, clean, clean-contaminated, contaminated, dirty. Wearing long-sleeved jackets while preparing and packaging items for sterilization Key words: long-sleeved jackets, organic material, sterile processing. Endoscopic transmission of prions Key words: prions, high-risk tissue, low-risk tissue, Creutzfeldt-Jakob disease (CJD), variant Creutzfeldt-Jakob disease (vCJD). Wearing gloves when handling flexible endoscopes Key words: gloves, low-protein, powder-free, natural rubber latex gloves, latex-free gloves. PMID:27129755

  6. Representations of mad cow disease.

    Science.gov (United States)

    Washer, Peter

    2006-01-01

    This paper examines the reporting of the story of Bovine Spongiform Encephalopathy (BSE) and its human derivative variant Creutzfeld-Jacob Disease (vCJD) in the British newspapers. Three 'snapshots' of newspaper coverage are sampled and analysed between the period 1986 and 1996 focusing on how representations of the disease evolved over the 10-year period. Social representations theory is used to elucidate how this new disease threat was conceptualised in the newspaper reporting and how it was explained to the UK public. This paper examines who or what was said to be at risk from the new disease, and whether some individuals or groups held to blame for the diseases' putative origins, the appearance of vCJD in human beings, and its spread. PMID:16046039

  7. QUESTION ANSWERING SYSTEM DAN PENERAPANNYA PADA ALKITAB

    Directory of Open Access Journals (Sweden)

    Gunawan Gunawan

    2006-01-01

    Full Text Available Question answering system is a system that allows user to state his or her information need in the form of natural language question, and return short text excerpts or even phrases as an answer. The availability of a wide and various information source and improvements in the techniques of natural language processing, information extraction (wrapper, and information retrieval give a big effect on the development of question answering system, from just answering questions in a specific domain by consulting to structured information source such as database, and like in this research, answering any questions based on information stored in an unstructured text collection. A general architecture of question answering system based on text consists of six processing stages, i.e. question analysis, document collection preprocessing, candidate document selection, candidate document analysis, answer extraction, and response generation. Application of question answering system like AnswerBus, Mulder, and Webclopedia that are developed with its own characteristics has similar processing steps as in the general architecture. Answers returned by a question answering system need to be evaluated for performance measure. This research completed with a simple question answering system application using english Bible in World English Bible (WEB version as the source of information to answer some questions. Because specific domain is selected: Bible, questions that can be posed by user could ask about information in the Bible itself only. Question is also limited to three types of answers that can be supported by the application: person (who, location (where, and date (when. Abstract in Bahasa Indonesia : Question answering system (QA system adalah sistem yang mengijinkan user menyatakan kebutuhan informasinya dalam bentuk natural language question (pertanyaan dalam bahasa alami, dan mengembalikan kutipan teks singkat atau bahkan frase sebagai jawaban. Ketersediaan

  8. Representations of mad cow disease

    OpenAIRE

    Washer, P.

    2006-01-01

    This paper examines the reporting of the story of Bovine Spongiform Encephalopathy (BSE) and its human derivative variant Creutzfeld-Jacob Disease (vCJD) in the British newspapers. Three ‘snapshots’ of newspaper coverage are sampled and analysed between the period 1986 and 1996 focusing on how representations of the disease evolved over the 10-year period. Social representations theory is used to elucidate how this new disease threat was conceptualised in the newspaper reporting a...

  9. Transmission of scrapie prions to primate after an extended silent incubation period

    OpenAIRE

    Emmanuel E Comoy; Mikol, Jacqueline; Luccantoni-Freire, Sophie; Correia, Evelyne; Lescoutra-Etchegaray, Nathalie; Durand, Valérie; Dehen, Capucine; Andreoletti, Olivier; Casalone, Cristina; Richt, Juergen A.; Greenlee, Justin J.; Baron, Thierry; Benestad, Sylvie L.; Brown, Paul; Deslys, Jean-Philippe

    2015-01-01

    Classical bovine spongiform encephalopathy (c-BSE) is the only animal prion disease reputed to be zoonotic, causing variant Creutzfeldt-Jakob disease (vCJD) in humans and having guided protective measures for animal and human health against animal prion diseases. Recently, partial transmissions to humanized mice showed that the zoonotic potential of scrapie might be similar to c-BSE. We here report the direct transmission of a natural classical scrapie isolate to cynomolgus macaque, a highly ...

  10. Current questions on space and time encoding.

    Science.gov (United States)

    Hasselmo, Michael E; Stern, Chantal E

    2015-06-01

    The Nobel Prize in Physiology or Medicine 2014 celebrated the groundbreaking findings on place cells and grid cells by John O'Keefe and May-Britt Moser and Edvard Moser. These findings provided an essential foothold for understanding the cognitive encoding of space and time in episodic memory function. This foothold provides a closer view of a broad new world of important research questions raised by the phenomena of place cells and grid cells. These questions concern the mechanisms of generation of place and grid cell firing, including sensory influences, circuit dynamics and intrinsic properties. Similar questions concern the generation of time cells. In addition, questions concern the functional role of place cells, grid cells and time cells in mediating goal-directed behavior and episodic memory function.

  11. Zika Virus and Complications: Questions and Answers

    Science.gov (United States)

    ... Feed Youtube Twitter Facebook Google + iTunes Play Store Zika virus and complications: Questions and answers Online Q& ... a cause of microcephaly and Guillain-Barré syndrome. Zika virus Updated! How do people catch Zika virus? ...

  12. Questions about Research That Makes a Difference.

    Science.gov (United States)

    Field, John

    1991-01-01

    Answers the following questions about transformative research: (1) is the concept needed? (2) does it represent a new methodology? (3) how does it relate to social movements? and (4) is it limited to postindustrial societies? (SK)

  13. Frequently Asked Questions about Digital Mammography

    Science.gov (United States)

    ... Consumer Information (MQSA) Frequently Asked Questions About Digital Mammography Share Tweet Linkedin Pin it More sharing options ... mammography exams, such as DBT? What is digital mammography? Full field digital mammography (FFDM, also known simply ...

  14. Frequently Asked Questions (FAQ) about Extreme Heat

    Science.gov (United States)

    ... of Emergencies Frequently Asked Questions (FAQ) About Extreme Heat Recommend on Facebook Tweet Share Compartir What happens ... body as a result of exposure to extreme heat? People suffer heat-related illness when the body’s ...

  15. Thymectomy: Common Questions Patients Ask about Thymectomies

    Science.gov (United States)

    ... The following are some of the most common questions asked when a thymectomy is being considered for adult and younger patients with autoimmune myasthenia gravis (MG). The answers supplied below are presented in ...

  16. FAQ: General Questions about West Nile Virus

    Science.gov (United States)

    ... Public Service Videos General Questions About West Nile Virus Recommend on Facebook Tweet Share Compartir On this ... West Nile virus cases? What is West Nile virus? West Nile virus is an arthropod-borne virus ( ...

  17. Scabies: Workplace Frequently Asked Questions (FAQs)

    Science.gov (United States)

    ... CDC.gov . Parasites - Scabies Parasites Home Share Compartir Workplace Frequently Asked Questions (FAQs) On This Page If ... local health department. We would like to create workplace guidelines in case an employee is diagnosed with ...

  18. Lyme Disease Frequently Asked Questions (FAQ)

    Science.gov (United States)

    ... Lyme disease FAQ Health care providers Educational materials Lyme Disease Frequently Asked Questions (FAQ) Language: English Español ( ... been bitten by a tick. Do I have Lyme disease? If you have not done so already, ...

  19. Frequently Asked Questions about Genetic Counseling

    Science.gov (United States)

    ... on this page Frequently Asked Questions About Genetic Counseling What are genetic professionals and what do they ... genetics nurses. Top of page What is genetic counseling and evaluation? Genetic professionals work as members of ...

  20. CREATING INNOVATIVE RESEARCH QUESTIONS: A PROBLEMATIZATION PERSPECTIVE

    OpenAIRE

    Stefan R. Ninković; Olivera Č. Knežević

    2015-01-01

    There are a number of intellectual reasons, professional norms and institutional mechanisms by which qualitative and quantitative research have been strongly driven towards the internaliza- tion – at least publicly preferred – of conventional modes of formulating research questions. At individual (researcher) and community (paradigm) levels, gap-spotting is the most common mode of formulating research questions. Given that in this way the assumptions of existing theoretical orientations are m...

  1. On the intonation of German intonation questions

    DEFF Research Database (Denmark)

    Petrone, Caterina; Niebuhr, Oliver

    2014-01-01

    German questions and statements are distinguished not only by lexical and syntactic but also by intonational means. This study revisits, for Northern Standard German, how questions are signalled intonationally in utterances that have neither lexical nor syntactic cues. Starting from natural......, but represents a separate attitudinal meaning dimension. Moreover, the findings support that both prenuclear and nuclear fundamental frequency (F0) patterns must be taken into account in the analysis of tune meaning....

  2. Key Questions in Marine Megafauna Movement Ecology

    OpenAIRE

    Hays, Graeme C.; Ferreira, Luciana C.; Sequeira, Ana M M; Meekan, Mark G; Duarte, Carlos M.; Bailey, Helen; Bailleul, Fred; Bowen, W. Don; Wikelski, Martin; Thums, Michele

    2016-01-01

    It is a golden age for animal movement studies and so an opportune time to assess priorities for future work. We assembled 40 experts to identify key questions in this field, focussing on marine megafauna, which include a broad range of birds, mammals, reptiles, and fish. Research on these taxa has both underpinned many of the recent technical developments and led to fundamental discoveries in the field. We show that the questions have broad applicability to other taxa, including terrestrial ...

  3. Four Principles for Selecting HCI Research Questions

    DEFF Research Database (Denmark)

    Clemmensen, Torkil

    In this position paper, I present and explain the position that what we should study in HCI depends on the objective of the research and its political, social, cultural, technological, and historical context. I outline four principles for selecting research questions and give a personal account...... of how I have selected research questions using these four principles. The aim with the paper is to generate discussion and advance the understanding of what to study in HCI....

  4. THE QUESTIONING IN SCIENCE AND IN PHILOSOPHY

    Directory of Open Access Journals (Sweden)

    Olesya Igorevna SOKOLOVA

    2015-01-01

    Full Text Available The article focuses on the problem of philosophy definition through its comparison with other forms of knowledge. It is noted that one of the specific features of philosophy is questioning. Questioning is understood as the existence of uncertainty in knowledge. The author analyzes the features of the questioning procedures in scientific research and in philosophy. In science the process of problem solutions and search of answers to the question under consideration plays a key role. One of specific features of philosophy is the existence of unsolvable questions. In the context of history of philosophy the author shows dependency of questions and answers on a particular cultural and historical situation. It is emphasized that philosophical approaches to science allow to analyze the changes of scientific paradigms and to recognize changeability of scientific knowledge. The author makes conclusions related to the role of philosophy in formulating problems in other forms of knowledge and possibility to go beyond the frame of paradigms limiting thinking. 

  5. From mad cows to sensible blood transfusion: the risk of prion transmission by labile blood components in the United Kingdom and in France.

    Science.gov (United States)

    Lefrère, Jean-Jacques; Hewitt, Patricia

    2009-04-01

    Transfusion transmission of the prion, the agent of variant Creutzfeldt-Jakob disease (vCJD), is now established. Subjects infected through food may transmit the disease through blood donations. The two nations most affected to date by this threat are the United Kingdom (UK) and France. The first transfusion cases have been observed in the UK over the past 5 years. In France, a few individuals who developed vCJD had a history of blood donation, leading to a risk of transmission to recipients, some of whom could be incubating the disease. In the absence of a large-scale screening test, it is impossible to establish the prevalence of infection in the blood donor population and transfused patients. This lack of a test also prevents specific screening of blood donations. Thus, prevention of transfusion transmission essentially relies at present on deferral of "at-risk" individuals. Because prions are present in both white blood cells and plasma, leukoreduction is probably insufficient to totally eliminate the transfusion risk. In the absence of a screening test for blood donations, recently developed prion-specific filters could be a solution. Furthermore, while the dietary spread of vCJD seems efficiently controlled, uncertainty remains as to the extent of the spread of prions through blood transfusion and other secondary routes. PMID:19170997

  6. From Question Answering to Visual Exploration

    Energy Technology Data Exchange (ETDEWEB)

    McColgin, Dave W.; Gregory, Michelle L.; Hetzler, Elizabeth G.; Turner, Alan E.

    2006-08-11

    Research in Question Answering has focused on the quality of information retrieval or extraction using the metrics of precision and recall to judge success; these metrics drive toward finding the specific best answer(s) and are best supportive of a lookup type of search. These do not address the opportunity that users? natural language questions present for exploratory interactions. In this paper, we present an integrated Question Answering environment that combines a visual analytics tool for unstructured text and a state-of-the-art query expansion tool designed to compliment the cognitive processes associated with an information analysts work flow. Analysts are seldom looking for factoid answers to simple questions; their information needs are much more complex in that they may be interested in patterns of answers over time, conflicting information, and even related non-answer data may be critical to learning about a problem or reaching prudent conclusions. In our visual analytics tool, questions result in a comprehensive answer space that allows users to explore the variety within the answers and spot related information in the rest of the data. The exploratory nature of the dialog between the user and this system requires tailored evaluation methods that better address the evolving user goals and counter cognitive biases inherent to exploratory search tasks.

  7. Some of the unanswered questions in finance

    Directory of Open Access Journals (Sweden)

    Đurić Dragana M.

    2006-01-01

    Full Text Available A very dynamic development of finance in the last 50 years is inter alia probably due to experiments and innovations in this field. Previously theoretical base could not explain and predict movements especially in volatile times. "The new finance" appeared 50 years ago (portfolio theory CAPM, the efficient market theory, M&M theorem and made substantial progress in understanding movements in globalized and internationalized financial markets. However, many questions remain open. The author tries to put emphasis on some of these questions, perfectly aware that these are not the only ones. Unresolved questions are related to company's aims, project's risks, degree of portfolio optimization, importance of liquidity, dividend policy, as well as factors that determine M&A. As the "new finance" is not able to predict and explain volatile movements, a question that should be posed is whether it is appropriate to add some non-economic factors as the behaviorist theory suggests. Although the behaviorist theory is an important part of "new finance", it is unfortunately the only theory able to explain movements in volatile times. In conclusion, many questions still remain unanswered and wait for appropriate theoretical explanations.

  8. Sporadic Creutzfeldt-Jakob Disease (sCJD)

    Centers for Disease Control (CDC) Podcasts

    2009-02-03

    In this podcast, Dr. Lynne Sehulster discusses Creutzfeldt-Jakob disease, a rare neurodegenerative disease. This disease is caused by a pathological accumulation in the brain of an abnormal protein known as prions.  Created: 2/3/2009 by Emerging Infectious Diseases.   Date Released: 2/3/2009.

  9. Dbpedia Based Factoid Question Answering System

    Directory of Open Access Journals (Sweden)

    Adel Tahri and Okba Tibermacine

    2013-07-01

    Full Text Available Question Answering (QA is an area of natural language processing research aimed at providing humanusers with a convenient and natural interface for accessing information. Nowadays, the need to developaccurate systems gains more importance due to available structured knowledge-bases and the continuousdemand to access information rapidly and efficiently. In This paper we propose a new architecture todevelop a factoid question answering system based on the DBpedia ontology and the DBpedia extractionframework. We use the SVM learning machine algorithm to train the systems question classifier to achievea high accuracy ratio. The design and implementation steps are covered with sufficient details. In addition,tests and experiment results of the developed system are presented with a short discussion about thesystems efficiency.

  10. Usability survey of biomedical question answering systems

    Directory of Open Access Journals (Sweden)

    Bauer Michael A

    2012-09-01

    Full Text Available Abstract We live in an age of access to more information than ever before. This can be a double-edged sword. Increased access to information allows for more informed and empowered researchers, while information overload becomes an increasingly serious risk. Thus, there is a need for intelligent information retrieval systems that can summarize relevant and reliable textual sources to satisfy a user's query. Question answering is a specialized type of information retrieval with the aim of returning precise short answers to queries posed as natural language questions. We present a review and comparison of three biomedical question answering systems: askHERMES (http://www.askhermes.org/, EAGLi (http://eagl.unige.ch/EAGLi/, and HONQA (http://services.hon.ch/cgi-bin/QA10/qa.pl.

  11. SALES STRATEGIES CENTERED ON ELABORATING QUESTIONS

    Directory of Open Access Journals (Sweden)

    Nelu DORLE

    2016-06-01

    Full Text Available Making a good sales approach depends largely on the strategy established by a salesperson, depending on the type of customer, the circumstances, and his/her psycho-linguistic availability. The sales strategies based on the science of reasoning, on the oratory and persuasive ability include skills related to communication, on which one of the most important is the development and asking of questions. The science related to the salesperson’s ability to handles questions in a sales interview gives the true measure of his/her professionalism. Elaborated based on the taxonomy of the sales steps and depending on customer objections, questions may constitute a basic premise in the development of sales strategies and techniques

  12. Do clinicians use more question marks?

    Science.gov (United States)

    Otte, Willem M; van’t Klooster, Maryse A; van Diessen, Eric; Leijten, Frans SS; Sander, Josemir W

    2015-01-01

    Objective To quantify the use of question marks in titles of published studies. Design and setting Literature review. Participants All Pubmed publications between 1 January 2013 and 31 December 2013 with an available abstract. Papers were classified as being clinical when the search terms clin*, med* or patient* were found anywhere in the paper’s title, abstract or the journal’s name. Other papers were considered controls. As a verification, clinical journals were compared to non-clinical journals in two different approaches. Also, 50 highest impact journals were explored for publisher group dependent differences. Main outcome measure Total number of question marks in titles. Results A total of 368,362 papers were classified as clinical and 596,889 as controls. Clinical papers had question marks in 3.9% (95% confidence interval 3.8–4.0%) of titles and other papers in 2.3% (confidence interval 2.3–2.3%; p < 0.001). These findings could be verified for clinical journals compared to non-clinical journals. Different percentages between four publisher groups were found (p < 0.01). Conclusion We found more question marks in titles of clinical papers than in other papers. This could suggest that clinicians often have a question-driven approach to research and scientists in more fundamental research a hypothesis-driven approach. An alternative explanation is that clinicians like catchy titles. Publishing groups might have pro- and anti-question mark policies. PMID:26085937

  13. Diet, health and globalization: five key questions.

    Science.gov (United States)

    Lang, T

    1999-05-01

    The present paper explores possible implications of the globalization of the food system for diet and health. The paper poses five key questions to clarify the relationship between food and globalization. The first question is what is globalization. The paper suggests that it is helpful to distinguish between economic, political, ideological and cultural processes. Globalization is also marked by internal oppositional dynamics: there are re-localization and regional tendencies which counter the global. The second question is whether there is anything new about globalization. Food has been a much traded commodity for millennia. The paper concludes that what is new about the current phases of globalization is the pace and scale of the change, and the fact that power is being concentrated into so few hands. New marketing techniques and supply-chain management consolidate these features. The third question is who is in control of the globalization era and who benefits and loses from the processes of globalization. It is argued that modern food economies are hypermarket rather than market economies, with power accruing to the distributor more than has been recognized. The fourth question concerns governance of the food system. Historically, systems of local and national government have regulated the food supply where appropriate. Now, new international systems are emerging, partly using existing bodies and partly creating new ones. The final question is of the future. Globalization is a value-laden area of study, yet its implications for dietary change and for health are considerable. The paper argues that dimensions of change can be discerned, although it would be rash to bet on which end of each dimension will emerge as dominant in the 21st century. PMID:10466175

  14. Asking a Great Question: A Librarian Teaches Questioning Skills to First-Year Medical Students.

    Science.gov (United States)

    Adams, Nancy E

    2015-01-01

    In a single one-hour session, first-year medical students were taught a framework for differentiating between lower-order questions that lead to knowledge of facts and higher-order questions that lead to integration of concepts and deeper learning, thereby preparing them for problem-based learning (PBL). Students generated lists of questions in response to an assertion prompt and categorized them according to Bloom's Taxonomy. These data were analyzed in addition to data from the course exam, which asked them to formulate a higher-level question in response to a prompt. Categorizing questions according to Bloom's Taxonomy was a more difficult task for students than was formulating higher-order questions. Students reported that the skills that they learned were used in subsequent PBL sessions to formulate higher-order learning objectives that integrated new and previously-learned concepts. PMID:26496396

  15. Some thoughts about the question of

    Directory of Open Access Journals (Sweden)

    Imre Gurzó

    2012-01-01

    Full Text Available The paper presents the main features of the policies which were followed by the left-liberal governments between 2002-2010. It sketches the state of the economy in Hungary in spring 2010, the most important measures taken by the Orbán government and the challenges, open questions and problems which need to be solved. It describes the most important political, economic, business, social, institutional and regional effects of Hungary’s EU membership, and in the end tries to sum up some important questions about the possible future.

  16. Questioning the Universe concepts in physics

    CERN Document Server

    Sadoff, Ahren

    2008-01-01

    UNITS AND POWERS OF TEN PHYSICS AND ITS METHODOLOGY  What Is Physics? Methodology The First Scientist Why Do You Believe? Back to the Questions How Do We Answer theQuestions? The Need to BeQuantitative Theories Models AestheticJudgments  MOTION Relating the Variables of Motion Graphs of One-Dimensional Motion Constant Speed Constant Acceleration Two-Dimensional Motion FORCES The Fundamental Forces A Specific Force Law: Newtonian Gravity Weight How Does Force Affect Motion? Newton's SecondLaw Newton, the Apple, and the Moon Combining Two Laws The Mass of the Earth Newton's Firs

  17. Key Questions in Marine Megafauna Movement Ecology.

    Science.gov (United States)

    Hays, Graeme C; Ferreira, Luciana C; Sequeira, Ana M M; Meekan, Mark G; Duarte, Carlos M; Bailey, Helen; Bailleul, Fred; Bowen, W Don; Caley, M Julian; Costa, Daniel P; Eguíluz, Victor M; Fossette, Sabrina; Friedlaender, Ari S; Gales, Nick; Gleiss, Adrian C; Gunn, John; Harcourt, Rob; Hazen, Elliott L; Heithaus, Michael R; Heupel, Michelle; Holland, Kim; Horning, Markus; Jonsen, Ian; Kooyman, Gerald L; Lowe, Christopher G; Madsen, Peter T; Marsh, Helene; Phillips, Richard A; Righton, David; Ropert-Coudert, Yan; Sato, Katsufumi; Shaffer, Scott A; Simpfendorfer, Colin A; Sims, David W; Skomal, Gregory; Takahashi, Akinori; Trathan, Philip N; Wikelski, Martin; Womble, Jamie N; Thums, Michele

    2016-06-01

    It is a golden age for animal movement studies and so an opportune time to assess priorities for future work. We assembled 40 experts to identify key questions in this field, focussing on marine megafauna, which include a broad range of birds, mammals, reptiles, and fish. Research on these taxa has both underpinned many of the recent technical developments and led to fundamental discoveries in the field. We show that the questions have broad applicability to other taxa, including terrestrial animals, flying insects, and swimming invertebrates, and, as such, this exercise provides a useful roadmap for targeted deployments and data syntheses that should advance the field of movement ecology. PMID:26979550

  18. Update: Creutzfeldt-Jakob disease associated with cadaveric dura mater grafts--Japan, 1978-2008.

    Science.gov (United States)

    2008-10-24

    Creutzfeldt-Jakob disease (CJD) is the most common of the human prion diseases (also known as transmissible spongiform encephalopathies), which, according to the leading hypothesis, are caused by an abnormal protein (i.e., prion) that is able to induce abnormal folding of normal cellular prion proteins. Annual worldwide incidence of these always fatal neurodegenerative diseases is estimated at 0.5-2.0 cases per million population. CJD can occur sporadically, or as a genetic disease, or can be transmitted iatrogenically. In 1996, a new human prion disease, variant CJD (vCJD), was first described in the United Kingdom. This disease was believed to have resulted from human consumption of cattle products contaminated with the prions responsible for bovine spongiform encephalopathy (BSE, commonly known as mad cow disease). That year, in part to check for possible vCJD cases, a national survey was conducted in Japan; 821 CJD cases were identified, including 43 cases associated with receipt of cadaveric dura mater grafts. A single brand of dural graft (Lyodura) produced by a German manufacturer before May 1987 was identified as the most likely vehicle of transmission in all but one case. By 2003, continued surveillance in Japan had identified a total of 97 such cases. Since then, an additional 35 cases have been identified. This report updates previous reports and summarizes the investigation of all 132 cases to date linked to dural grafts. The results suggest that, because of the long incubation period between graft receipt and symptom onset (possibly >24.8 years), continued surveillance in Japan might identify additional CJD cases associated with dural grafts. PMID:18946463

  19. Question Moments’: A Rolling Programme of Question Opportunities in Classroom Science

    OpenAIRE

    Pedrosa de Jesus, MH; Leite, S.; Watts, DM

    2015-01-01

    This article has been made available through the Brunel Open Access Publishing Fund. This naturalistic study integrates specific 'question moments' into lesson plans to increase pupils' classroom interactions. A range of teaching tools has explored students' ideas through opportunities to ask and write questions. Their oral and written outcomes provide data on individual and group misunderstandings. Changes to the schedule of lessons were introduced to discuss these questions a...

  20. Question moments’: a rolling programme of question-opportunities in classroom science

    OpenAIRE

    Pedrosa-de-Jesus, HM; Leite, S.; Watts, M.

    2016-01-01

    This naturalistic study integrates specific ‘question moments’ into lesson plans to increase pupils’ classroom interactions. A range of tools explored students’ ideas by providing students with opportunities to ask and write questions. Their oral and written outcomes provide data on individual and group misunderstandings. Changes to the schedule of lessons were introduced to explore these questions and address disparities. Flexible lesson planning over 14 lessons across a 4-week period of hig...

  1. Questions & Answers about...Marfan Syndrome.

    Science.gov (United States)

    National Inst. of Arthritis and Musculoskeletal and Skin Diseases (NIH), Bethesda, MD.

    This fact sheet answers general questions about Marfan syndrome, a heritable condition that affects the connective tissue. It describes the characteristics of the disorder, the diagnostic process, and ways to manage symptoms. Characteristics include: (1) people with Marfan syndrome are typically very tall, slender, and loose jointed; (2) more than…

  2. Common Questions about Sexual Health Education.

    Science.gov (United States)

    McKay, Alexander

    2000-01-01

    Provides research-based answers to questions commonly posed by educators, parents, and others about the philosophy, methods, and impact of school sexual health education, discussing such issues as: whether these school programs are needed, what values they teach, whether the programs should teach about sexual orientation and abstinence, and…

  3. Treatment of Anthrax Disease Frequently Asked Questions

    Energy Technology Data Exchange (ETDEWEB)

    Judd, Kathleen S.; Young, Joan E.; Lesperance, Ann M.; Malone, John D.

    2010-05-14

    This document provides a summary of Frequently Asked Questions (FAQs) on the treatment of anthrax disease caused by a wide-area release of Bacillus anthracis spores as an act bioterrorism. These FAQs are intended to provide the public health and medical community, as well as others, with guidance and communications to support the response and long-term recovery from an anthrax event.

  4. Gendering China studies: peripheral perspectives, central questions

    NARCIS (Netherlands)

    J. de Kloet

    2008-01-01

    This article explores the connections between the field of China studies and the field of gender and sexuality studies. It engages with three questions. First, why is it that theoretical, conceptual and methodological cross-fertilization between China studies and cultural studies remains quite scarc

  5. Answering Young Children's Questions about Sex.

    Science.gov (United States)

    Hansen, Gladys

    Intended for use by parents and teachers of preschool age children, this short booklet provides some guidelines to follow when introducing sex education to young children. It discusses issues such as where to begin, how to encourage the child to ask questions about sex, how to handle sex-related problems, child molestation, nudity and the family,…

  6. Natural Language Question Answering in Open Domains

    Directory of Open Access Journals (Sweden)

    Dan Tufis

    2011-10-01

    Full Text Available With the ever-growing volume of information on the web, the traditional search engines, returning hundreds or thousands of documents per query, become more and more demanding on the user patience in satisfying his/her information needs. Question Answering in Open Domains is a top research and development topic in current language technology. Unlike the standard search engines, based on the latest Information Retrieval (IR methods, open domain question-answering systems are expected to deliver not a list of documents that might be relevant for the user's query, but a sentence or a paragraph answering the question asked in natural language. This paper reports on the construction and testing of a Question Answering (QA system which builds on several web services developed at the Research Institute for Artificial Intelligence (ICIA/RACAI. The evaluation of the system has been independently done by the organizers of the ResPubliQA 2009 exercise and has been rated the best performing system with the highest improvement due to the natural language processing technology over a baseline state-of-the-art IR system. The system was trained on a specific corpus, but its functionality is independent on the linguistic register of the training data.

  7. Dog Bite Reflections--Socratic Questioning Revisited

    Science.gov (United States)

    Toledo, Cheri A.

    2015-01-01

    In the online environment, the asynchronous discussion is an important tool for creating community, developing critical thinking skills, and checking for understanding. As students learn how to use Socratic questions for effective interactions, the discussion boards can become the most exciting part of the course. This sequel to the article…

  8. Key Questions in Marine Megafauna Movement Ecology

    KAUST Repository

    Hays, Graeme C.

    2016-03-12

    It is a golden age for animal movement studies and so an opportune time to assess priorities for future work. We assembled 40 experts to identify key questions in this field, focussing on marine megafauna, which include a broad range of birds, mammals, reptiles, and fish. Research on these taxa has both underpinned many of the recent technical developments and led to fundamental discoveries in the field. We show that the questions have broad applicability to other taxa, including terrestrial animals, flying insects, and swimming invertebrates, and, as such, this exercise provides a useful roadmap for targeted deployments and data syntheses that should advance the field of movement ecology. Technical advances make this an exciting time for animal movement studies, with a range of small, reliable data-loggers and transmitters that can record horizontal and vertical movements as well as aspects of physiology and reproductive biology.Forty experts identified key questions in the field of movement ecology.Questions have broad applicability across species, habitats, and spatial scales, and apply to animals in both marine and terrestrial habitats as well as both vertebrates and invertebrates, including birds, mammals, reptiles, fish, insects, and plankton. © 2016 Elsevier Ltd.

  9. Questions on uncertainties in parton distributions

    International Nuclear Information System (INIS)

    A discussion is presented of the manner in which uncertainties in parton distributions and related quantities are determined. One of the central problems is the criteria used to judge what variation of the parameters describing a set of partons is acceptable within the context of a global fit. Various ways of addressing this question are outlined. (author)

  10. Public Opinion Poll Question Databases: An Evaluation

    Science.gov (United States)

    Woods, Stephen

    2007-01-01

    This paper evaluates five polling resource: iPOLL, Polling the Nations, Gallup Brain, Public Opinion Poll Question Database, and Polls and Surveys. Content was evaluated on disclosure standards from major polling organizations, scope on a model for public opinion polls, and presentation on a flow chart discussing search limitations and usability.

  11. Culture Heritage Digital Repositories. Research Questions

    OpenAIRE

    Stanchev, Peter

    2010-01-01

    This discussion is about innovative solutions for assembling multimedia digital repositories for collaborative use in specific contexts and communities and enhancing scholarly understanding and experiences of digital cultural heritage. Several aspects are stress such as the dynamic aggregation of cross-media resources across existing institutional digital libraries and repositories. Research questions about the scalability, interoperability and distributed architectures, aggregation, an...

  12. 8 Questions About the Conscious Mind

    NARCIS (Netherlands)

    Dooremalen, A.J.P.W.

    2014-01-01

    Can the mind function separately from the brain? Can machines have conscious minds? Is Google Maps part of the conscious mind? Hans Dooremalen provides answers to these three and five other questions about the conscious mind in an easy to read introduction to the philosophy of mind.

  13. Some Questions about Feature Re-Assembly

    Science.gov (United States)

    White, Lydia

    2009-01-01

    In this commentary, differences between feature re-assembly and feature selection are discussed. Lardiere's proposals are compared to existing approaches to grammatical features in second language (L2) acquisition. Questions are raised about the predictive power of the feature re-assembly approach. (Contains 1 footnote.)

  14. Response to Questions on Presentation to NAS

    Energy Technology Data Exchange (ETDEWEB)

    Meier, W R

    2011-03-17

    Response to questions on the presentation 'Overview to Chamber and Power Plant Designs for IFE' made at the 1/29-31 meeting of the National Academies Committee on the Prospects for Inertial Confinement Fusion Energy Systems.

  15. The prevalence of questionable occlusal caries

    DEFF Research Database (Denmark)

    Makhija, Sonia K; Gilbert, Gregg H; Funkhouser, Ellen;

    2012-01-01

    Questionable occlusal caries (QOC) can be defined as clinically suspected caries with no cavitation or radiographic evidence of occlusal caries. To the authors' knowledge, no one has quantified the prevalence of QOC, so this quantification was the authors' objective in conducting this study...

  16. Do clinicians use more question marks?

    NARCIS (Netherlands)

    Zijlmans, Maeike; Otte, Willem M; Van't Klooster, Maryse A; van Diessen, Eric; Leijten, Frans Ss; Sander, Josemir W

    2015-01-01

    OBJECTIVE: To quantify the use of question marks in titles of published studies. DESIGN AND SETTING: Literature review. PARTICIPANTS: All Pubmed publications between 1 January 2013 and 31 December 2013 with an available abstract. Papers were classified as being clinical when the search terms clin*,

  17. Reading and Questioning in Content Area Lessons.

    Science.gov (United States)

    Armbruster, Bonnie B.; And Others

    1991-01-01

    Determines how science and social studies textbooks were used by teachers and students in 12 fourth grade lessons and what kinds of questions the teachers asked during the lessons. Finds that students do not get much practice reading informational text, and instruction often fails to promote conceptual understanding and meaningful learning from…

  18. The Big Questions of Public Administration Education.

    Science.gov (United States)

    Denhardt, Robert B.

    2001-01-01

    Identifies four questions related to public administration education: (1) do we seek to educate students with respect to theory or practice? (2) do we prepare students for first jobs or later jobs? (3) what are appropriate delivery systems? and (4) what personal commitments do we make as public administrators? (Contains 48 references.) (JOW)

  19. Brain Training Draws Questions about Benefits

    Science.gov (United States)

    Sparks, Sarah D.

    2012-01-01

    While programs to improve students' working memory are among the hottest new education interventions, new studies are calling into question whether exercises to improve this foundational skill can actually translate into greater intelligence, problem-solving ability, or academic achievement. Working memory is the system the mind uses to hold…

  20. Frequently Asked Questions about Colonoscopy and Sigmoidoscopy

    Science.gov (United States)

    ... saved articles window. My Saved Articles » My ACS » Your Local Offices Close + - Text Size Frequently Asked Questions About Colonoscopy and Sigmoidoscopy Colonoscopy (KO-lun- AH -skuh-pee) and sigmoidoscopy (SIG-moid- AH -skuh-pee) are ...

  1. Using Questions To Facilitate Motor Skill Acquisition.

    Science.gov (United States)

    Knight, G. William; And Others

    1997-01-01

    Describes a dental teaching strategy that promotes acquisition of psychomotor skills through use of metacognition and problem-solving. In five steps, questions are asked to guide the learner through a sequence of discriminations leading to recognition of problems and solutions. Clearly defined criteria in a sequence reflecting procedure are…

  2. Questions About Venus after Venus Express

    Science.gov (United States)

    Limaye, Sanjay

    2016-04-01

    The observations from Venus Express for nearly 13 Venus years or 26 solar days from April 2006 till 27 November 2014. Earlier, Venus has been explored by fly-by spacecraft, orbiters, descending probes, landers and floating balloons. These data have been supplemented by many ground based observations at reflected solar wavelengths, short and long wave infrared, millimeter to radio waves. Venus Express added significantly to the collection that will continue to be examined for understanding the planet's atmosphere and continuing analysis will inform us about new facets of the atmosphere and raise new questions. Inter-comparison of the measurements have been able to provide a general idea of the global atmosphere. However, re-visiting these observations also raises some questions about the atmosphere that have not received much attention lately but deserve to be explored and considered for future measurements. These questions are about the precise atmospheric composition in the deep atmosphere, the atmospheric state in the lower atmosphere, the static stability of the lower atmosphere, the clouds and hazes, the nature of the ultraviolet absorber(s) in the cloud layer, and wind speed and direction near the surface from equator to the pole, interaction between the atmosphere and the solid planet. The answers to these questions are important for a better understanding of Venus, its weather and climate and how the climate has evolved. The questions include: (i) What are the implications of the supercritical state of the two primary constituents of the Venus atmosphere - carbon dioxide and nitrogen in the lower atmosphere? (ii) Is the Venus (lower) atmosphere well mixed? (iii) What determines the observed alternating stable and unstable layers (static stability) in the lower atmosphere? (iv) What causes the contrasts seen in reflected sunlight which are largest at ultraviolet wavelengths and very muted at other visible wavelengths? (v) what causes the morning -afternoon

  3. "Question Moments": A Rolling Programme of Question Opportunities in Classroom Science

    Science.gov (United States)

    Pedrosa-de-Jesus, Helena; Leite, Sara; Watts, Mike

    2016-01-01

    This naturalistic study integrates specific "question moments" into lesson plans to increase pupils' classroom interactions. A range of tools explored students' ideas by providing students with opportunities to ask and write questions. Their oral and written outcomes provide data on individual and group misunderstandings. Changes to the…

  4. The Importance of Questioning & Questions for Consideration in Programming for Intercultural Language Learning

    Science.gov (United States)

    Morgan, Anne-Marie

    2008-01-01

    The significance of questioning in intercultural language learning was highlighted during Phase 1 of the project as project team members worked with teachers preparing units of work and long-term programs. This paper explores the types of questions asked by team members to elicit teachers' thinking regarding students' learning and teachers' roles…

  5. Twenty Open Questions in Supersymmetric Particle Physics

    CERN Document Server

    Dienes, Keith R; Dienes, Keith R.; Kolda, Christopher

    1997-01-01

    We give a brief overview of 20 open theoretical questions in supersymmetric particle physics. The 20 questions we have chosen range from the GeV scale to the Planck scale, and include issues pertaining to the Minimal Supersymmetric Standard Model and its extensions, SUSY-breaking, cosmology, grand unified theories, and string theory. Throughout, our goal is to address those topics in which supersymmetry plays a fundamental role, and which are areas of active research in the field. This survey is written at an introductory level and is aimed at people who are not necessarily experts in the field. (To appear as an Overview Chapter in the review volume "Perspectives on Supersymmetry", edited by G. Kane, to be published by World Scientific.)

  6. Basic Questions on Artin-Tits groups

    CERN Document Server

    Godelle, Eddy

    2011-01-01

    This paper is a short survey on four basic questions on Artin-Tits groups: the torsion, the center, the word problem, and the cohomology ($K(\\pi,1)$ problem). It is also an opportunity to prove three new results concerning these questions: (1) if all free of infinity Artin-Tits groups are torsion free, then all Artin-Tits groups will be torsion free; (2) If all free of infinity irreducible non-spherical type Artin-Tits groups have a trivial center then all irreducible non-spherical type Artin-Tits groups will have a trivial center; (3) if all free of infinity Artin-Tits groups have solutions to the word problem, then all Artin-Tits groups will have solutions to the word problem. Recall that an Artin-Tits group is free of infinity if its Coxeter graph has no edge labeled by $\\infty$.

  7. Analysis of questioned documents: a review.

    Science.gov (United States)

    Calcerrada, Matías; García-Ruiz, Carmen

    2015-01-01

    During the last years (2000-2014), many publications concerning the forensic analysis of questioned documents have been published, and new techniques and methodologies are nowadays employed to overcome forensic caseworks. This article reviews a comprehensive collection of the works focused on this issue, including dating studies, the analysis of inks from pens and printers, the analysis of paper, the analysis of other samples related to questioned documents and studies on intersecting lines. These sections highlight the most relevant analytical studies by a wide range of analytical techniques. Separation and spectrometric techniques are critically discussed and compared, emphasizing the advantages and disadvantages of each one. Finally, concluding remarks on the research published are included.

  8. Empirical questions for collective-behaviour modelling

    Indian Academy of Sciences (India)

    Nicholas T Ouellette

    2015-03-01

    The collective behaviour of groups of social animals has been an active topic of study across many disciplines, and has a long history of modelling. Classical models have been successful in capturing the large-scale patterns formed by animal aggregations, but fare less well in accounting for details, particularly for groups that do not display net motion. Inspired by recent measurements of swarming insects, which are not well described by the classical modelling paradigm, I pose a set of questions that must be answered by any collective-behaviour model. By explicitly stating the choices made in response to each of these questions, models can be more easily categorized and compared, and their expected range of validity can be clarified.

  9. The ethics of physicists in questions

    CERN Multimedia

    2000-01-01

    Four CERN physicists, Peggie Rimmer, Ugo Amaldi, Alain Blondel, and Jean-Marie Le Goff, answered questions from 150 college students last Monday during a debate on the theme of the ethics of physics. Organized by CERN and the Department of public instruction of the Canton of Geneva, the meeting followed a reading by the students of the play Die Physiker, by Friedrich Dürrenmatt, which raises the problem of political exploitation of discoveries made during the second world war. The Minister of Education of the Canton de Genève, Mrs Martine Brunschwig-Graf, took part in the debate. The questions posed by students were not lacking in pertinence : Should a physicist reveal a discovery that is dangerous in his opinion ? Who are responsible, those who make the discoveries or those who use them ?

  10. Searching for a question and an answer

    Directory of Open Access Journals (Sweden)

    J. Le Roux

    2012-02-01

    Full Text Available This article focusses on Eckart Otto’s theory of the Pentateuch, his contribution to Pro Pent (the “Project for the study of the Pentateuch” and his influence on our understanding of the first five books of the Hebrew Bible. There was something in his thinking that appealed to many South African scholars; an appeal that softened down the harsh criticism and blunted the sharp edges of Pentateuch study of the past two centuries. And this was accomplished by turning the focus to the theological and ethical issues, which were the driving forces behind the formation of the Pentateuch. Put differently: to show the Pentateuch as an answer to a question and Pentateuch criticism as a constant search for the questions to which the Pentateuch is answer.

  11. Biology of cancer: some questions to answer.

    Science.gov (United States)

    Chapekar, T

    2001-10-01

    Though great advances in cancer biology have taken place through these years, some fundamental questions are still to be explained. Some observations in this regard are discussed in the present paper. In the course of experimental studies on hormonal stimulation of target cells, it was observed that goat granulosa cells showed differential proliferative response to sustained stimulation by oLH and hCG in culture. oLH caused cells to proliferate whereas hCG failed to stimulate the cells though both the gonadotropins have common receptors on the target cell. Further studies might throw some light on the mechanism of signal transduction in cell biology and neoplasia. A question is also posed as to how to interpret thermodynamically the sustained growth of cancer vis-a-vis the host.

  12. Transnational aspects of the Kurdish question

    OpenAIRE

    Bruinessen, M.M. van

    2007-01-01

    Simplifying a complex question, one may observe that the objectives of all Kurdish political movements of the past century have concerned two central issues, culture and territory. The Kurdish language and the region historically known as Kurdistan are the Kurds’ most important national symbols. It is only seemingly a paradox that many of the most active participants in the present Kurdish movement (especially so in the case of Turkey’s Kurds) speak but little Kurdish and have long lived outs...

  13. Forty questions on singularities of algebraic varieties

    OpenAIRE

    Hauser, Herwig; Schicho, Josef

    2011-01-01

    The reader will find in this article a collection of problems, questions and exercises related to the singularities of algebraic and analytic varieties. Many of them are inspired by the work and mathematical conception of Hironaka: they are concrete, involve basic ideas and techniques from geometry and algebra, and they can immediately be attacked from scratch. Some problems rely on or use results proven by Hironaka. Simple and double asterisques indicate the more difficult pro...

  14. Ankylosing Spondylitis: a Reflection and a Question

    Directory of Open Access Journals (Sweden)

    Annia Deysi Hernández Martín

    2014-07-01

    Full Text Available Ankylosing spondylitis is a chronic inflammatory disease that affects the synovial membrane, joint entheses and para-articular structures of the spine, including the sacroiliac joints and limbs. We present a case of ankylosing spondylitis that had evolved for 12 years despite the relatively early diagnosis and treatment, showing flexion deformity and limitation of spinal movements. On radiological examination an early evolution to ankylosis was observed, which motivated us to make a reflection and a question.

  15. The global knowledge economy in question

    OpenAIRE

    Roberts, Joanne

    2009-01-01

    Purpose – The aim of this paper is to bring into question the idea of the global knowledge economy. Design/methodology/approach – The paper explores the characteristics of the knowledge economy, as elaborated by academics and policy makers concerned with knowledge in the contemporary global business environment. A range of available data is reviewed concerning the global distribution of investments in knowledge, information and communications technologies (ICTs), international transactions in...

  16. Twenty-five questions for string theorists

    Energy Technology Data Exchange (ETDEWEB)

    Binetruy, Pierre; /Orsay, LPT; Kane, G.L.; /Michigan U., MCTP; Lykken, Joseph D.; /Fermilab; Nelson, Brent D.; /Pennsylvania U.

    2005-09-01

    In an effort to promote communication between the formal and phenomenological branches of the high-energy theory community, we provide a description of some important issues in supersymmetric and string phenomenology. We describe each within the context of string constructions, illustrating them with specific examples where applicable. Each topic culminates in a set of questions that we believe are amenable to direct consideration by string theorists, and whose answers we think could help connect string theory and phenomenology.

  17. Questions Concerning Schwarzschild's Solution of Einstein's Equations

    CERN Document Server

    Dunning-Davies, J

    2005-01-01

    Now that an English translation of Schwarzschild's original work exists, that work has become accessible to more people. Here his original solution to the Einstein field equations is examined and it is noted that it does not contain the mathematical singularity normally associated with the existence of a black hole. Einstein's own views on this subject are considered also and it is seen that, at the very least, grave questions exist over the possible existence of these somewhat esoteric stellar objects.

  18. Questions that calls for a genius

    CERN Multimedia

    McKie, Robin

    2006-01-01

    "Last week an eccentric Russian was tipped to win a "Maths Nobel" for solving the fiendishly difficult Poincare Conjecture, one of seven major "millennium" mathematical mysteries that have been earmarked for urgent solution. But these problems are just the tip of a scientific iceberg. Other fields are also beset by frustrating theoretical failures. Here Robin McKie highlights the most baffing of those questions and suggests how science will one day provide those elusive answers." (1 page)

  19. Medical Marijuana: More Questions than Answers

    OpenAIRE

    Hill, Kevin P.

    2014-01-01

    With 23 states and the District of Columbia having enacted medical marijuana laws as of August 2014, it is important that psychiatrists be able to address questions about medical marijuana from patients, families, and other health care professionals. The author discusses the limited medical literature on synthetic cannabinoids and medical marijuana. The synthetic cannabinoids dronabinol and nabilone are approved by the United States Food and Drug Administration for nausea and vomiting associa...

  20. Functional symptoms in neurology: questions and answers

    OpenAIRE

    Reuber, M; A. Mitchell; Howlett, S.; Crimlisk, H; Grunewald, R

    2005-01-01

    Between 10 and 30% of patients seen by neurologists have symptoms for which there is no current pathophysiological explanation. The objective of this review is to answer questions many neurologists have about disorders characterised by unexplained symptoms (functional disorders) by conducting a multidisciplinary review based on published reports and clinical experience. Current concepts explain functional symptoms as resulting from auto-suggestion, innate coping styles, disorders of volition ...

  1. Model Answers to Lipid Membrane Questions

    DEFF Research Database (Denmark)

    Mouritsen, O. G.

    2011-01-01

    Ever since it was discovered that biological membranes have a core of a bimolecular sheet of lipid molecules, lipid bilayers have been a model laboratory for investigating physicochemical and functional properties of biological membranes. Experimental and theoretical models help the experimental...... to pursue. Here we review some membrane models for lipid self-assembly, monolayers, bilayers, liposomes, and lipid-protein interactions and illustrate how such models can help answering questions in modern lipid cell biology....

  2. Comments on topical questions of nuclear energy

    International Nuclear Information System (INIS)

    During the 7th legislative period (1972/76) of the German Bundestag the Federal Government has repeatedly commented on questions concerning nuclear energy. The present documentation comprises a selection of the most important issues. The collection contains in particular: written and oral answers of the Federal Government to written or oral questions of members of parliament; answers of the Federal Government to major and minor interpellations of fractions or factions; statements of the chancellor, the ministers and permanent secretaries; bills of the Federal Government if they were issued as parliamentary documents or as plenary minutes. The main attention when selecting the documents was drawn to giving complete recording of the statements on the safety of nuclear plants and on radiation protection. Furthermore, the comments on questions concerning nuclear energy were considered both in general and in connection with alternative energy sources. Eventually, the general situation concerning energy could be verified. The selection of documents has certainly not thoroughly remained uninfluenced by subjective decisions. The parliamentary documents and plenary minutes given here are recorded by chronological order. An index of subject headings will facilitate access to all documents. (orig.) 891 HP

  3. Management of polychlorinated biphenyls (PCBs) questions & answers

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-11-01

    This {open_quotes}Management of PCBs Questions and Answers{close_quotes} has been developed from a presentation given by Dr. John Smith of the Environmental Protection Agency (EPA), and the transcribed question and answer session which followed the presentation. Dr. Smith was featured at the first DOE complex-wide PCB Focus Group meeting held in San Francisco, California in December 1992. The meeting was attended by representatives from field elements who were actively involved in the management of PCBs. The meeting served as a forum for the exchange of information and discussion of PCB management issues. This document has been prepared as one of several guidance documents developed by the Department of Energy Office of Environmental Policy and Assistance (EH-41) (formerly the Office of Environmental Guidance, EH-23) to assist DOE elements in their PCB management programs. This document is organized into three parts: (1) an introduction describing the conception and development of this document, (2) a summary of Dr. Smith`s presentation, and (3) the question and answer session.

  4. CREATING INNOVATIVE RESEARCH QUESTIONS: A PROBLEMATIZATION PERSPECTIVE

    Directory of Open Access Journals (Sweden)

    Stefan R. Ninković

    2015-12-01

    Full Text Available There are a number of intellectual reasons, professional norms and institutional mechanisms by which qualitative and quantitative research have been strongly driven towards the internaliza- tion – at least publicly preferred – of conventional modes of formulating research questions. At individual (researcher and community (paradigm levels, gap-spotting is the most common mode of formulating research questions. Given that in this way the assumptions of existing theoretical orientations are more or less merely reproduced in a programmed manner, it is unlikely that such studies will result in original and influential contributions. In this context, it is reasonable to ask the following questions: Did the educational research lost its way? Do educational researchers have anything to say? Has the research in education become a routine (uninspiring, isomorphic and irrelevant? The paper indicates that problematization makes an obvious but seldom used alternative strat- egy of formulating research questions. The basic idea of the paper is to promote the approach that critically and constructively analyze and indicate the limited nature of premises, perspectives, implications, language and other elements of dominant theoretical orientations, aimed at challeng- ing them and considering a set of alternative options instead. Specifically, problematization means locating, articulating and criticizing the assumptions of existing literature, and thus, formulating research questions that encourage the development of interesting and relevant knowledge. It has been found that problematization cannot be reduced to a fixed or even strictly routine procedure, since it necessarily involves a dialectical and dialogical process. On one hand, the principle of “everything is possible” by no means can be applied in problematization; on the other hand, problematization cannot be conducted in any universally perfect way. As a dynamic non- linear process, it is

  5. Frequently asked questions: iodinated contrast agents.

    Science.gov (United States)

    Bettmann, Michael A

    2004-10-01

    Although iodinated contrast agents are safe and widely used, adverse events occur and questions remain about their use, safety, and interactions. Some questions are easily answered and others still require extensive investigation. For one frequent question--is informed consent necessary before all contrast media injections--the simple answer is no. Another question concerns use of contrast media in patients with prior reactions or allergies. Contrast agents can be safely used in such patients, but special care must be taken to be aware of what the previous reaction was and to be ready to treat any reaction. The protective role of pre-treatment with steroids is well established for minor reactions, but they may not prevent major reactions. It is important to realize that even life-threatening, anaphylactoid reactions are not the result of a true allergy to contrast media. Many questions arise about contrast agent-induced nephropathy. Baseline serum creatinine values should be obtained in patients who are at risk, not all patients. The incidence and natural history of contrast agent-induced nephropathy remain unclear. It occurs only in patients with compromised renal function before contrast agent injection, but even patients with normal serum creatinine levels can have renal dysfunction. Calculated creatinine clearance is a better way to determine risk and to follow this complication. The outcome in almost all patients is benign, with progression to end-stage renal disease being rare. The major risk factors, in addition to renal dysfunction, are long-standing diabetes mellitus, dehydration, and use of other nephrotoxic medications. Recent work in preventing and ameliorating contrast agent-induced nephropathy with N-acetyl cysteine, substitution of an isosmolal nonionic contrast agent, and various hydration regimens has been promising. Another common concern is use of iodinated contrast agents in pregnant or breast-feeding women. In both cases, there is no evidence

  6. Cerebroventricular infusion of pentosan polysulphate in human variant Creutzfeldt-Jakob disease.

    Science.gov (United States)

    Todd, N V; Morrow, J; Doh-ura, K; Dealler, S; O'Hare, S; Farling, P; Duddy, M; Rainov, N G

    2005-06-01

    Variant Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy believed to be caused by the bovine spongiform encephalopathy agent, an abnormal isoform of the prion protein (PrP(sc)). At present there is no specific or effective treatment available for any form of CJD. Pentosan polysulphate (PPS), a large polyglycoside molecule with weak heparin-like activity, has been shown to prolong the incubation period of the intracerebral infection when administered to the cerebral ventricles in a rodent scrapie model. PPS also prevents the production of further PrP(sc) in cell culture models. These properties of PPS prompted its cerebroventricular administration in a young man with vCJD. Long-term continuous infusion of PPS at a dose of 11 microg/kg/day for 18 months did not cause drug-related side effects. Follow-up CT scans demonstrated progressive brain atrophy during PPS administration. Further basic and clinical research is needed in order to address the issue of efficacy of PPS in vCJD and in other prion diseases. PMID:15907546

  7. Cerebroventricular infusion of pentosan polysulphate in human variant Creutzfeldt-Jakob disease.

    Science.gov (United States)

    Todd, N V; Morrow, J; Doh-ura, K; Dealler, S; O'Hare, S; Farling, P; Duddy, M; Rainov, N G

    2005-06-01

    Variant Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy believed to be caused by the bovine spongiform encephalopathy agent, an abnormal isoform of the prion protein (PrP(sc)). At present there is no specific or effective treatment available for any form of CJD. Pentosan polysulphate (PPS), a large polyglycoside molecule with weak heparin-like activity, has been shown to prolong the incubation period of the intracerebral infection when administered to the cerebral ventricles in a rodent scrapie model. PPS also prevents the production of further PrP(sc) in cell culture models. These properties of PPS prompted its cerebroventricular administration in a young man with vCJD. Long-term continuous infusion of PPS at a dose of 11 microg/kg/day for 18 months did not cause drug-related side effects. Follow-up CT scans demonstrated progressive brain atrophy during PPS administration. Further basic and clinical research is needed in order to address the issue of efficacy of PPS in vCJD and in other prion diseases.

  8. Preclinical deposition of pathological prion protein in muscle of experimentally infected primates.

    Directory of Open Access Journals (Sweden)

    Susanne Krasemann

    Full Text Available Prion diseases are transmissible fatal neurodegenerative disorders affecting humans and animals. A central step in disease progression is the accumulation of a misfolded form (PrP(Sc of the host encoded prion protein (PrP(C in neuronal and non-neuronal tissues. The involvement of peripheral tissues in preclinical states increases the risk of accidental transmission. On the other hand, detection of PrP(Sc in non-neuronal easy-accessible compartments such as muscle may offer a novel diagnostic tool. Primate models have proven invaluable to investigate prion diseases. We have studied the deposition of PrP(Sc in muscle and central nervous system of rhesus monkeys challenged with sporadic Creutzfeldt-Jakob disease (sCJD, variant CJD (vCJD and bovine spongiform encephalopathy (BSE in preclinical and clinical stage using biochemical and morphological methods. Here, we show the preclinical presence of PrP(Sc in muscle and central nervous system of rhesus monkeys experimentally infected with vCJD.

  9. `Question Moments': A Rolling Programme of Question Opportunities in Classroom Science

    Science.gov (United States)

    Pedrosa-de-Jesus, Helena; Leite, Sara; Watts, Mike

    2016-06-01

    This naturalistic study integrates specific `question moments' into lesson plans to increase pupils' classroom interactions. A range of tools explored students' ideas by providing students with opportunities to ask and write questions. Their oral and written outcomes provide data on individual and group misunderstandings. Changes to the schedule of lessons were introduced to explore these questions and address disparities. Flexible lesson planning over 14 lessons across a 4-week period of high school chemistry accommodated students' contributions and increased student participation, promoted inquiring and individualised teaching, with each teaching strategy feeding forward into the next.

  10. Question Processing and Clustering in INDOC: A Biomedical Question Answering System

    Directory of Open Access Journals (Sweden)

    Ankush Mittal

    2007-12-01

    Full Text Available The exponential growth in the volume of publications in the biomedical domain has made it impossible for an individual to keep pace with the advances. Even though evidence-based medicine has gained wide acceptance, the physicians are unable to access the relevant information in the required time, leaving most of the questions unanswered. This accentuates the need for fast and accurate biomedical question answering systems. In this paper we introduce INDOC—a biomedical question answering system based on novel ideas of indexing and extracting the answer to the questions posed. INDOC displays the results in clusters to help the user arrive the most relevant set of documents quickly. Evaluation was done against the standard OHSUMED test collection. Our system achieves high accuracy and minimizes user effort.

  11. Toward Question-Asking Machines: The Logic of Questions and the Inquiry Calculus

    Science.gov (United States)

    Knuth,Kevin H.

    2005-01-01

    For over a century, the study of logic has focused on the algebra of logical statements. This work, first performed by George Boole, has led to the development of modern computers, and was shown by Richard T. Cox to be the foundation of Bayesian inference. Meanwhile the logic of questions has been much neglected. For our computing machines to be truly intelligent, they need to be able to ask relevant questions. In this paper I will show how the Boolean lattice of logical statements gives rise to the free distributive lattice of questions thus defining their algebra. Furthermore, there exists a quantity analogous to probability, called relevance, which quantifies the degree to which one question answers another. I will show that relevance is not only a natural generalization of information theory, but also forms its foundation.

  12. Question Processing and Clustering in INDOC: A Biomedical Question Answering System

    Directory of Open Access Journals (Sweden)

    Sondhi Parikshit

    2007-01-01

    Full Text Available The exponential growth in the volume of publications in the biomedical domain has made it impossible for an individual to keep pace with the advances. Even though evidence-based medicine has gained wide acceptance, the physicians are unable to access the relevant information in the required time, leaving most of the questions unanswered. This accentuates the need for fast and accurate biomedical question answering systems. In this paper we introduce INDOC—a biomedical question answering system based on novel ideas of indexing and extracting the answer to the questions posed. INDOC displays the results in clusters to help the user arrive the most relevant set of documents quickly. Evaluation was done against the standard OHSUMED test collection. Our system achieves high accuracy and minimizes user effort.

  13. Sustainable Questions: Determining the Expiration Date of Answers

    OpenAIRE

    Goede, de, E.D.; Schuth, A; Rijke, de, M.

    2012-01-01

    Community question answering platforms have large repositories of already answered questions. Reusing these answers for new questions is tempting. However, not all stored answers will still be relevant. In this study, we define a new and challenging problem concerning the sustainability of questions and answers, and present metrics aimed at distinguishing between sustainable and unsustain- able questions. We find that an intuitive approach to sustainability of questions is not sufficient, but...

  14. Asking practical ethical questions about youth participation

    Directory of Open Access Journals (Sweden)

    Kim Knowles-Yanez

    2009-06-01

    Full Text Available This paper is based on case study research conducted in an economically depressed, immigrant gateway neighborhood of Escondido, California. This study has been in progress since 2005 and involves working with children at the local middle school on rights-based community environmental action research projects in coordination with student facilitators in an upper-division uni- versity class titled “Children and the Environment.” This case study has suggested inquiry into the practical ethical dimensions of working with children, administrators, and university students on action research. Examples of the ethical questions which arose during this study include: how can continuity for the middle school children be achieved as different groups of university students move in and out of the project as they take and finish the “Children and the Environment” class, and is it ethical for the middle school children’s work to be facilitated by university students only freshly trained in the action research technique? This paper explores these and other ethical questions involving power, coercion, tension over expectations, and obligation and pro- vides direction for on-going ethical questions scholars should pursue in involving children in rights-based community environmental action research. Cet article se base sur une étude de cas menée dans un quartier immigrant défavorisé d’Escondido, Californie. Commencée en 2005, l’étude comporte le travail avec des enfants dans l’école secondaire locale autour des projets de recherche-action environnementale communautaire dans une approche de respect et de promotion des droits, avec la collaboration d’animateurs d’une université, inscrits dans le cours « Les enfants et l’environnement ». Cette étude de cas a soulevé des questions sur les dimensions éthiques du travail avec des enfants, le personnel scolaire et des étudiants universitaires dans la recherche-action. Comment peut

  15. Why worship? Revisiting a fundamental liturgical question

    Directory of Open Access Journals (Sweden)

    Johan Cilliers

    2009-03-01

    Full Text Available In this article the fundamental liturgical question as to the motive and intention of worship is addressed within the framework of four related liturgical tensions, namely between being and becoming, between time and space, between awe and expression, and between laughter and lament. In order to do this, some classical voices from the past are listened to, for instance, Schleiermacher, Kierkegaard, Moltmann, Tillich, Otto, Bakhtin and Buber, but more contemporary views are also considered. These four tensions are described in the light of the key terms: ‘already’ and ‘not yet’, and some implications for present-day liturgical practices are drawn.

  16. Frequently asked questions on filtered noise

    DEFF Research Database (Denmark)

    Blanke, Mogens

    This note was made in response to several returning questions on noise and ways to calculate covariance of filtered random signals, where filters could origin from residual generators. Reference is made to stochastic signals treated in appendix 2 of the book Diagnosis and Fault-tolerant Control b...... by Blanke, Kinnaert, Lunze and Staroswiecki, 2003. The note is aimed at graduate students who follow their first course in diagnosis and fault-tolerant control where design of appropriate filters is an important part of the design of fault diagnosis....

  17. On Drury's solution of Bhatia \\& Kittaneh's question

    OpenAIRE

    Lin, Minghua

    2016-01-01

    Let $A, B$ be $n\\times n$ positive semidefinite matrices. Bhatia and Kittaneh asked whether it is true $$ \\sqrt{\\sigma_j(AB)}\\le \\frac{1}{2} \\lambda_j(A+B), \\qquad j=1, \\ldots, n$$ where $\\sigma_j(\\cdot)$, $\\lambda_j(\\cdot)$, are the $j$-th largest singular value, eigenvalue, respectively. The question was recently solved by Drury in the affirmative. This article revisits Drury's solution. In particular, we simplify the proof for a key auxiliary result in his solution.

  18. Study Questions Reliability of Fingerprint Evidence

    Institute of Scientific and Technical Information of China (English)

    James; Randerson; 陈易

    2007-01-01

    The reliability of fingerprint has been called into question by a study that tested whether forensic experts make consistent judgments on print matches.Despite the perceived infallibility of fingerprint evidence, the study found that experts do not always make the same judgment on whether a print matches a mark at a crime scene when presented with the same evidence twice.The findings come in the wake of two high profile cases in which fingerprint matches were subsequently shown to be wrong. The Scottish ...

  19. Guarino Guarini open questions, possible solutions

    CERN Document Server

    2009-01-01

    Baroque architect and mathematician Guarino Guarini is the subject of this issue of the Nexus Network Journal. A group of international scholars were invited to contribute papers that shed light on the unanswered questions in several areas: Baroque architecture in general and Guarini’s architecture in particular; philosophy; history of structural mechanics; mathematics and history of mathematics, cosmology. As always, the NNJ takes an interdisciplinary approach to the broad range of subjects that Guarini concerned himself with, thus the final results will add significantly to our understanding of how Guarini’s actual practical and technical processes were informed by knowledge of his multifaceted scientific and philosophical interests.

  20. Questioning Styles in Vocational College English Classrooms

    Institute of Scientific and Technical Information of China (English)

    舒立志

    2011-01-01

    This study investigates the effects of TBLT reform in Higher Vocational Colleges from the perspective of questioning styles.It employs three methods to collect data:classroom observation,semi-structured interviews and focus group discussion with eight English teachers and their 384 non-English major students from three Higher Vocational Colleges in Guangdong.The results indicated that the teachers assigned students different tasks to perform in class.They seemed to be adopting the TBLT approach,but their English classes were not totally different from the teacher-centered grammar-focused lessons,the student-centered or communicative lessons.

  1. Prima Facie Questions in Quantum Gravity

    CERN Document Server

    Isham, C J

    2009-01-01

    The long history of the study of quantum gravity has thrown up a complex web of ideas and approaches. The aim of this article is to unravel this web a little by analysing some of the {\\em prima facie\\/} questions that can be asked of almost any approach to quantum gravity and whose answers assist in classifying the different schemes. Particular emphasis is placed on (i) the role of background conceptual and technical structure; (ii) the role of spacetime diffeomorphisms; and (iii) the problem of time.

  2. Nuclear energy by way of 110 questions

    International Nuclear Information System (INIS)

    The main goal of this updated edition is to provide the general public with information on the civil nuclear policy in France. Twelve chapters deal with following topics: nuclear economy, nuclear industry, nuclear fuel cycle and nuclear waste, nuclear safety, radioactivity and health, nuclear accidents in the world, nuclear energy and environment, inspection planning, information, nuclear proliferation prevention, nuclear energy in the world and in the future. At the end of each chapter the authors answer a set of questions corresponding to the general pubic queries. (N.T.)

  3. The Electromagnetic Compatibility Research Group: research questions

    Directory of Open Access Journals (Sweden)

    Francisco José Román Campos

    2010-06-01

    Full Text Available This paper summarises the Universidad Nacional de Colombia’s Electrical and Electronic Engineering Department’s Electromag- netic Compatibility Research Group (EMC-UNC activities during the last 30 years. The group was involved in developing experimental tools during the early 1980s, such as constructing high-voltage apparatus, developing high-voltage practical work for students and observing electrical discharges. These tools enabled the group to spend a decade focused on resolving one of the Colombian electrical sector’s main EMC problems: distribution transformer’s failures caused by lightning. For almost a decade this investigation was focused on understanding the causes of the extremely high failure index in Colombian rural areas, especially in the Rionegro basin. The main result of this investigation was a reduction by one order of magnitude in mean 10% distribution transformer failure rate. During this research work a noticeable pattern was observed of several electrically-isolated me- tallic bodies immersed in an electric field (i.e. floating electrodes. This was led to initiating floating electrode studies and for mulating a new scientific question, “How do corona electrical discharges interact with floating electrodes?” This new research question was dealt with during the second half of the 1990s and the first decade of the 2000s. This investigation was related to using electrostatically-accumulated charge on a floating electrode. This question opened up four research areas: gas discharge physics, generating fast current impulses, harvesting energy from the electric field and the possibility of high impedance current sources. This paper has summarised the most relevant work done by the EMC-UNC group on these topics. This floating electrode research work started by formulating four patents. Fresh research questions for the 2010s were related to measuring lightning electromagnetic pulses (LEMP, intentional electromagnetic

  4. Reconnection in Solar Flares: Outstanding Questions

    Indian Academy of Sciences (India)

    Hiroaki Isobe; Kazunari Shibata

    2009-06-01

    Space observations of solar flares such as those from Yohkoh, SOHO,TRACE, and RHESSI have revealed a lot of observational evidence of magnetic reconnection in solar flares: cusp-shaped arcades, reconnection inflows, plasmoids, etc. Thus it has been established, at least phenomenologically, that magnetic reconnection does occur in solar flares. However, a number of fundamental questions and puzzles still remain in the physics of reconnection in solar flares. In this paper, we discuss the recent progresses and future prospects in the study of magnetic reconnection in solar flares from both theoretical and observational points of view.

  5. Circulations of Law: Colonial Precedents, Contemporary Questions

    OpenAIRE

    Iza Hussin

    2012-01-01

    While the project of law-making has seemed an obvious and inherent part of empire-building, and law-delivery has often been a justifying rationale for imperialism, this paper asks more detailed questions about the travels of law. How is a ‘universal’ law made ‘local’, and to what effect? How have past and contemporary legal delivery projects delineated between the categories of local and universal? Our analytic project, therefore, is not simply that law travels, but wi...

  6. Audel questions and answers for electrician's examinations

    CERN Document Server

    Rosenberg, Paul

    2011-01-01

    An essential resource for passing electrician's examinations To pass your state and local licensing exams, you need knowledge and confidence. This comprehensive review guide gives you plenty of both. It's packed with sample questions to help you focus your efforts, review material on all aspects of the 2011 National Electrical Code (NEC), the lowdown on business competency requirements, and tips for studying and test-taking that will help you conquer anxiety ahead.Learn the definitions, specifications, and regulations of the 2011 NEC Acquire test-taking skills with example

  7. Four open questions in massive star evolution

    CERN Document Server

    Meynet, Georges; Ekstrom, Sylvia; Georgy, Cyril; Groh, Jose; Maeder, Andre; Saio, Hideyuki; Moriya, Takashi

    2013-01-01

    We discuss four questions dealing with massive star evolution. The first one is about the origin of slowly rotating, non-evolved, nitrogen rich stars. We propose that these stars may originate from initially fast rotating stars whose surface has been braked down. The second question is about the evolutionary status of alpha-Cygni variables. According to their pulsation properties, these stars should be post red supergiant stars. However, some stars at least present surface abundances indicating that they should be pre red supergiant stars. How to reconcile these two contradictory requirements? The third one concerns the various supernova types which are the end point of the evolution of stars with initial masses between 18 and 30 Msun, i.e. the most massive stars which go through a red supergiant phase during their lifetime. Do they produce types IIP, IIL, IIn, IIb or Ib supernovae or do they end without producing any SN event? Finally, we shall discuss reasons why so few progenitors of type Ibc supernovae ha...

  8. [5ARI and PSA: open questions.

    Science.gov (United States)

    Tubaro, Andrea; Puccini, Federica; De Nunzio, Cosimo

    2014-09-23

    No consensus has ever been reached on the predictive value of serum prostate specific antigen(PSA) for the diagnosis of prostate cancer. Limitations of PSA testing in clinical practice have beenoften discussed in the peer-reviewed literature following data derived from clinical trials such as theProstate Cancer Prevention Trial (PCPT) and the Reduction by Dutasteride of Prostate Cancer Events(REDUCE) study that showed a linear rise in the risk of prostate cancer with increasing PSA levels.Benign prostatic hyperplasia is a known confounding factor for the use of PSA as a marker of prostatecancer. Increased prostate volume observed with ageing, urinary retention, acute and chronicinflammatory conditions of the prostate, sexual activity and digital rectal examination may all cause anincrease of PSA values. Both finasteride and dutasteride, 5-alpha reductase inhibitors (5ARI) used inthe treatment of BPH, are known to induce a significant decrease of serum PSA levels close to 50%.The observed change in PSA values following 5ARI treatment has raised questions about the accuracyof PSA testing for the early diagnosis of prostate cancer in patients on finasteride/dutasteride treatment.Careful analysis of data from various clinical trials on pharmacological treatment of LUTS due toBPH suggested that the accuracy of PSA testing is not just maintained but rather increased following5ARI use. Then, the question of PSA accuracy during 5ARI treatment can be considered closed. PMID:25350562

  9. Minors and social networks: legal questions

    Directory of Open Access Journals (Sweden)

    Francisca Ramón Fernández

    2015-04-01

    Full Text Available The participation in a company increasingly technological does that numerous questions appear on the protection of the most vulnerable subjects, between them the minors. The influence of the social networks like instrument of communication is not exempt from risks for the quantity of information that is facilitated and is shared. The lack of a specific regulation that he contemplates from the point of view of the Law which is the protection that a minor must have, does that there take place situations of abandonment of the rights of the same ones.The opportunity of regulation has been left to escape in the future law of protection of the infancy, nowadays in phase of preliminary design, since it does not refer to the social networks since it had been desirable. The current procedure as for minors, as well as those of protection of information, between others, do not turn out to be sufficient to contemplate all the situations of risk that can be given in the above mentioned area. In the present work we propose to think on minors and social networks raising some legal questions, and trying to contribute some response to the problematics that appears in the juridical area.

  10. Karl Mannheim’s Jewish Question

    Directory of Open Access Journals (Sweden)

    David Kettler

    2012-04-01

    Full Text Available In this paper, we explore Karl Mannheim’s puzzling failure (or refusal to address himself in any way to questions arising out of the position of Jews in Germany, either before or after the advent of Nazi rule—and this, notwithstanding the fact, first, that his own ethnic identification as a Jew was never in question and that he shared vivid experiences of anti-Semitism, and consequent exile from both Hungary and Germany, and, second, that his entire sociological method rested upon using one’s own most problematic social location—as woman, say, or youth, or intellectual—as the starting point for a reflexive investigation. It was precisely Mannheim’s convictions about the integral bond between thought grounded in reflexivity and a mission to engage in a transformative work of Bildung that made it effectively impossible for him to formulate his inquiries in terms of his way of being Jewish. It is through his explorations of the rise and fall of the intellectual as socio-cultural formation that Mannheim investigates his relations to his Jewish origins and confronts the disaster of 1933. The key to our puzzle is to be found in the theory of assimilation put forward in the dissertation of his student, Jacob Katz.

  11. Frequently asked questions in hypoxia research

    Directory of Open Access Journals (Sweden)

    Wenger RH

    2015-09-01

    Full Text Available Roland H Wenger,1,2 Vartan Kurtcuoglu,1,2 Carsten C Scholz,1,2 Hugo H Marti,3 David Hoogewijs1,2,4 1Institute of Physiology and Zurich Center for Human Physiology (ZIHP, University of Zurich, 2National Center of Competence in Research “Kidney.CH”, Zurich, Switzerland; 3Institute of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, 4Institute of Physiology, University of Duisburg-Essen, Essen, Germany Abstract: “What is the O2 concentration in a normoxic cell culture incubator?” This and other frequently asked questions in hypoxia research will be answered in this review. Our intention is to give a simple introduction to the physics of gases that would be helpful for newcomers to the field of hypoxia research. We will provide background knowledge about questions often asked, but without straightforward answers. What is O2 concentration, and what is O2 partial pressure? What is normoxia, and what is hypoxia? How much O2 is experienced by a cell residing in a culture dish in vitro vs in a tissue in vivo? By the way, the O2 concentration in a normoxic incubator is 18.6%, rather than 20.9% or 20%, as commonly stated in research publications. And this is strictly only valid for incubators at sea level. Keywords: gas laws, hypoxia-inducible factor, Krogh tissue cylinder, oxygen diffusion, partial pressure, tissue oxygen levels

  12. Two Questions about Data-Oriented Parsing

    CERN Document Server

    Bod, R

    1996-01-01

    In this paper I present ongoing work on the data-oriented parsing (DOP) model. In previous work, DOP was tested on a cleaned-up set of analyzed part-of-speech strings from the Penn Treebank, achieving excellent test results. This left, however, two important questions unanswered: (1) how does DOP perform if tested on unedited data, and (2) how can DOP be used for parsing word strings that contain unknown words? This paper addresses these questions. We show that parse results on unedited data are worse than on cleaned-up data, although very competitive if compared to other models. As to the parsing of word strings, we show that the hardness of the problem does not so much depend on unknown words, but on previously unseen lexical categories of known words. We give a novel method for parsing these words by estimating the probabilities of unknown subtrees. The method is of general interest since it shows that good performance can be obtained without the use of a part-of-speech tagger. To the best of our knowledge...

  13. Supply chain design: Some critical questions

    Directory of Open Access Journals (Sweden)

    J. D. Nel

    2010-11-01

    Full Text Available Effective supply chain management (SCM requires organisations to work together in order to satisfy the needs of their end customers. Since organisations have to determine which processes and relationships will best achieve this aim, the design of their supply chains is important. Supply chain design thus forms an integral part of SCM and embodies the supply chain's structure. Unfortunately, too many organisations allow the design of their supply chain to evolve into its current form instead of planning their supply chain design (SCD efforts. The literature is vague on what SCD efforts constitute. This article consists of a comprehensive literature study in which an effort was made to bring more clarity on exactly what purposeful SCD efforts consist of, and some key questions were formulated that organisations could use as a guide in their SCD practices. From these critical questions a conceptual framework has been developed that can be used to determine whether organisations' SCD practices are aligned with organisational objectives. The conceptual framework was tested at two South African organisations to determine if it indeed can be be used to analyse the SCD practices of organisations.

  14. Does a perception of increased blood safety mean increased blood transfusion? An assessment of the risk compensation theory in Canada

    Directory of Open Access Journals (Sweden)

    Wilson Kumanan

    2004-06-01

    Full Text Available Abstract Background The risk compensation theory is a widely used concept in transport economics to analyze driver risk behaviour. This article explores the feasibility of applying the theory in blood transfusion to raise important questions regarding the increased blood safety measures and their possible effects on blood usage (e.g., the appropriateness in transfusion. Further, it presents the findings of a pilot survey of physicians in Canada. Discussion While studies have attempted to define transfusion appropriateness, this article argues that if the risk compensation theory holds true for transfusion practice, physicians may actually be transfusing more. This may increase the possibility of contracting other unknown risks, such as the variant Creutzfeldt-Jakob Disease (vCJD, as well as increasing the risk of non-infectious transfusion risks, such as transfusion reactions. Summary A much larger study involving psychosocial assessment of physician decision making process to fully assess physician behaviour within the context of risk compensation theory and transfusion practice in Canada is needed to further explore this area.

  15. Cross-domain question classification in community question answering via kernel mapping

    Science.gov (United States)

    Su, Lei; Hu, Zuoliang; Yang, Bin; Li, Yiyang; Chen, Jun

    2015-10-01

    An increasingly popular method for retrieving information is via the community question answering (CQA) systems such as Yahoo! Answers and Baidu Knows. In CQA, question classification plays an important role to find the answers. However, the labeled training examples for statistical question classifier are fairly expensive to obtain, as they require the experienced human efforts. Meanwhile, unlabeled data are readily available. This paper employs the method of domain adaptation via kernel mapping to solve this problem. In detail, the kernel approach is utilized to map the target-domain data and the source-domain data into a common space, where the question classifiers are trained under the closer conditional probabilities. The kernel mapping function is constructed by domain knowledge. Therefore, domain knowledge could be transferred from the labeled examples in the source domain to the unlabeled ones in the targeted domain. The statistical training model can be improved by using a large number of unlabeled data. Meanwhile, the Hadoop Platform is used to construct the mapping mechanism to reduce the time complexity. Map/Reduce enable kernel mapping for domain adaptation in parallel in the Hadoop Platform. Experimental results show that the accuracy of question classification could be improved by the method of kernel mapping. Furthermore, the parallel method in the Hadoop Platform could effective schedule the computing resources to reduce the running time.

  16. An alarming presentation of Creutzfeldt-Jakob disease following a self-inflicted gunshot wound to the head.

    Science.gov (United States)

    Harnish, Carissa; Gross, Brian; Rittenhouse, Katelyn; Bupp, Katherine; Vellucci, Ashley; Anderson, Jeffrey; Riley, Deborah; Rogers, Frederick B

    2015-05-01

    Transmissible spongiform encephalopathies (TSE), also known as prion diseases, are characterized by rapid and fatal neurological decline. They not only detrimentally affect the patient, but also present additional challenges to healthcare systems due to the infectivity of the tissues and the difficulty of inactivating the prion. The most common TSE is Creutzfeldt-Jakob disease (CJD), which can occur after familial, spontaneous or acquired transmission. TSEs received more attention after the development of variant CJD (vCJD), also known as Mad Cow Disease, in the UK during the mid-1990s. Unlike familial or spontaneous CJD, this variant was connected to consumption of cattle contaminated with the prion disease, bovine spongiform encephalopathy.This development increased interest in the etiology of CJD and other TSEs and the risk it presents as an infectious disease. The following details the case of a 59-year-old male infected with CJD presented to our level II trauma center for treatment following a self-inflicted gunshot wound to the head. PMID:25530409

  17. Metabolic patterns in prion diseases: an FDG PET voxel-based analysis

    International Nuclear Information System (INIS)

    Clinical diagnosis of human prion diseases can be challenging since symptoms are common to other disorders associated with rapidly progressive dementia. In this context, 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) might be a useful complementary tool. The aim of this study was to determine the metabolic pattern in human prion diseases, particularly sporadic Creutzfeldt-Jakob disease (sCJD), the new variant of Creutzfeldt-Jakob disease (vCJD) and fatal familial insomnia (FFI). We retrospectively studied 17 patients with a definitive, probable or possible prion disease who underwent FDG PET in our institution. Of these patients, 12 were diagnosed as sCJD (9 definitive, 2 probable and 1 possible), 1 was diagnosed as definitive vCJD and 4 were diagnosed as definitive FFI. The hypometabolic pattern of each individual and comparisons across the groups of subjects (control subjects, sCJD and FFI) were evaluated using a voxel-based analysis. The sCJD group exhibited a pattern of hypometabolism that affected both subcortical (bilateral caudate, thalamus) and cortical (frontal cortex) structures, while the FFI group only presented a slight hypometabolism in the thalamus. Individual analysis demonstrated a considerable variability of metabolic patterns among patients, with the thalamus and basal ganglia the most frequently affected areas, combined in some cases with frontal and temporal hypometabolism. Patients with a prion disease exhibit a characteristic pattern of brain metabolism presentation in FDG PET imaging. Consequently, in patients with rapidly progressive cognitive impairment, the detection of these patterns in the FDG PET study could orient the diagnosis to a prion disease. (orig.)

  18. Metabolic patterns in prion diseases: an FDG PET voxel-based analysis

    Energy Technology Data Exchange (ETDEWEB)

    Prieto, Elena; Dominguez-Prado, Ines; Jesus Ribelles, Maria; Arbizu, Javier [Clinica Universidad de Navarra, Nuclear Medicine Department, Pamplona (Spain); Riverol, Mario; Ortega-Cubero, Sara; Rosario Luquin, Maria; Castro, Purificacion de [Clinica Universidad de Navarra, Neurology Department, Pamplona (Spain)

    2015-09-15

    Clinical diagnosis of human prion diseases can be challenging since symptoms are common to other disorders associated with rapidly progressive dementia. In this context, {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography (PET) might be a useful complementary tool. The aim of this study was to determine the metabolic pattern in human prion diseases, particularly sporadic Creutzfeldt-Jakob disease (sCJD), the new variant of Creutzfeldt-Jakob disease (vCJD) and fatal familial insomnia (FFI). We retrospectively studied 17 patients with a definitive, probable or possible prion disease who underwent FDG PET in our institution. Of these patients, 12 were diagnosed as sCJD (9 definitive, 2 probable and 1 possible), 1 was diagnosed as definitive vCJD and 4 were diagnosed as definitive FFI. The hypometabolic pattern of each individual and comparisons across the groups of subjects (control subjects, sCJD and FFI) were evaluated using a voxel-based analysis. The sCJD group exhibited a pattern of hypometabolism that affected both subcortical (bilateral caudate, thalamus) and cortical (frontal cortex) structures, while the FFI group only presented a slight hypometabolism in the thalamus. Individual analysis demonstrated a considerable variability of metabolic patterns among patients, with the thalamus and basal ganglia the most frequently affected areas, combined in some cases with frontal and temporal hypometabolism. Patients with a prion disease exhibit a characteristic pattern of brain metabolism presentation in FDG PET imaging. Consequently, in patients with rapidly progressive cognitive impairment, the detection of these patterns in the FDG PET study could orient the diagnosis to a prion disease. (orig.)

  19. Unveiling Student understanding: The Role of Questioning in Instruction

    Institute of Scientific and Technical Information of China (English)

    罗新兵

    2004-01-01

    One of the most striking aspects of teaching is that the teacher' s speech consists of questions, These questions are central to the type of learning that takes place in the classroom. Naturally, questions are built around varying forms of thinking. Some questions are aimed at recall of information, whereas others provoke

  20. Teaching Children with Autism To Ask Questions about Hidden Objects.

    Science.gov (United States)

    Williams, Gladys; Donley, Corrine R.; Keller, Jennie W.

    2000-01-01

    A study successfully taught 2 4-year-olds with autism to ask questions of an adult who held a closed box with a toy inside. The first question produced the name of the toy, the second question produced the sight of it, and the third question produced the item itself. (Contains three references.) (Author/CR)

  1. Begging the Question: Some Pragmatic Aspects of Argument.

    Science.gov (United States)

    Wilson, Kent

    Begging the question, or the "petitio" fallacy, is problematic for logicians because rules of logic dictate that if an argument of a particular form begs the question at issue, any other argument of the same form also begs the question; yet such questions can appear satisfactory in other contexts. The fallacy benefits from considering the…

  2. Ethical Questions in Medical Electronic Adherence Monitoring.

    Science.gov (United States)

    Campbell, Jeffrey I; Eyal, Nir; Musiimenta, Angella; Haberer, Jessica E

    2016-03-01

    Electronic adherence monitors (EAMs) record and report an array of health behaviors, ranging from taking daily medications to wearing medical devices. EAMs are utilized in research worldwide and are being investigated for clinical use. However, there is also growing popular concern about the extent to which electronic devices may be used to monitor individuals, including allegations in the media that EAMs represent a move towards "Big Brother" in medicine. Here, we highlight the unique benefits as well as the potential ethical challenges that electronic adherence monitoring generates. These challenges surround autonomy, privacy and confidentiality, trust, and ancillary care obligations. We describe key questions within each of these domains that warrant further investigation, and present potential solutions to many of the concerns raised. PMID:26358284

  3. Telephone operator change: your questions answered

    CERN Multimedia

    CERN Bulletin

    2015-01-01

    CERN will be changing mobile telephone operators on 24 June. As the community prepares for the summer switchover, everyone has questions. What brought on the change? Why are we losing our old phone numbers? What kind of improvements will we see? "Just as with every contract at CERN, we issue calls for tenders every few years to ensure we are still receiving the best possible service," explains Tony Cass, from the Communication Systems group within the IT department. "As we came to the end of our contract with Sunrise, we put out a call for tenders, which was won by Swisscom. Not only is their pricing more competitive, they will also be providing better service conditions." The scope of these new service conditions is multifaceted: there will be improvements to the redundancy and reliability of the network as well as modern 4G network coverage in the LHC tunnel. "People will also see their mobile phone bills decrease," says Tony. "This will esp...

  4. Global bioevents and the question of periodicity

    Science.gov (United States)

    Sepkoski, J. John

    The hypothesis of periodicity in extinction is an empirical claim that extinction events, while variable in magnitude, are regular in timing and therefore are serially dependent upon some single, ultimate cause with clocklike behavior. This hypothesis is controversal, in part because of questions regarding the identity and timing of certain extinction events and because of speculations concerning possible catastrophic extraterrestrial forcing mechanisms. New data on extinctions of marine animal genera are presented that display a high degree of periodicity in the Mesozoic and Cenozoic as well as a suggestion of nonstationary periodicity in the late Paleozoic. However, no periodicity is evident among the as yet poorly documented extinction events of the early and middle Paleozoic.

  5. Questions of Modern Cosmology Galileo's Legacy

    CERN Document Server

    D'Onofrio, Mauro

    2009-01-01

    Are we living in the "golden age" of cosmology? Are we close to understanding the nature of the unknown ingredients of the currently most accepted cosmological model and the physics of the early Universe? Or are we instead approaching a paradigm shift? What is dark matter and does it exist? How is it distributed around galaxies and clusters? Is the scientific community open to alternative ideas that may prompt a new scientific revolution - as the Copernican revolution did in Galileo's time? Do other types of supernovae exist that can be of interest for cosmology? Why have quasars never been effectively used as standard candles? Can you tell us about the scientific adventure of COBE? How does the extraction of the Cosmic Microwave Background anisotropy depend on the subtraction of the various astrophysical foregrounds? These, among many others, are the astrophysical, philosophical and sociological questions surrounding modern cosmology and the scientific community that Mauro D'Onofrio and Carlo Burigana pose t...

  6. Who Knows? Question Format and Political Knowledge

    DEFF Research Database (Denmark)

    Robison, Joshua

    2015-01-01

    Political knowledge is one of the most influential variables in political science. However, scholars still grapple with its theoretical meaning and how to measure it best. I address the deeply contested issue of whether knowledge should be measured with either an open-ended or closed-choice measure....... Beyond exploring the effects of these contested approaches on estimates of overall levels of mass knowledge, I also study how they influence who is deemed knowledgeable and explore how this affects a variety of attitudes. I find that measurement dramatically matters on all of these dimensions. In short......, the results reported here raise important questions about the validity of knowledge indices and also have implications for the general study of political attitudes and behavior....

  7. Organizational Learning: Some Basic Questions and Answers

    Directory of Open Access Journals (Sweden)

    Miran Mihelčič

    2014-05-01

    Full Text Available The term “organizational learning” raises a broad range of questions, specifically with regard to its contents. Following the thoughts of eminent philosophers, such as Aristotle and Confucius, the contribution of scientists in any research field to the corpus of human knowledge should also be based on the proper governing of the use of language. Therefore it is, first, of serious importance to be aware that organizational learning is just one dimension or element of the learning organization and not vice versa; second, a good comprehension of basic categories related to the organizational side of (formal social units’ functioning is an imperative part of organizational learning process. In writing this paper, the author started from his experiences acquired in his role as a lecturer on the subject “Theory of Organization”, in which the goal of lecturing was explained to students as gaining knowledge about cooperation and competition of people in the entities of rational production of goods. To generalize the presented questions and answers regarding the use of term “organization” in the field of management, certain similarities and comparisons were sought and found in other fields of science and, more generally, in life itself. After more detailed explanations of other relevant categories for the organizational learning process, the process itself is defined by its goals and steps where the overlapping of the learning process with the organizational change process and the process of increasing organizational capital is shown. Finally, it is also emphasized that the idea of improving internal relationships – as the substance of organization – between employees in a formal social unit through organizational learning could and should be exploited in external relationships between formal social units.

  8. A Comparative Analysis Between TIMSS-R (1999 Questions and LGS (1999 Questions in Life Science

    Directory of Open Access Journals (Sweden)

    Özlem AFACAN

    2008-04-01

    Full Text Available The association made international evaluation in education field (IEA, matches the countries wanted to be added in science and mathematics field with examination doing every four years. This examination applied third times in 1999 and Turkey attended to it first time.This research is a quality methods including survey models. The aim of this research is to compare between LGS and TIMSS-R questions about subject of life science and to interpret their questions’ content. These questions’ analysis was done with Bloom’s Taxonomy. The Bloom’s Taxonomy includes sub titles of information, comprehension, apply, analysis, synthesis and evaluation. Every questions in both of LGS and TIMSS-R compared with their sub titles. In the results of study show that the questions’category is very important for them. It is suggested that questions analyzed with Bloom should have equilibrium context and distribution

  9. Questioning the Patient, Questioning Hippocrates: Rufus of Ephesus and the Pursuit of Knowledge.

    Science.gov (United States)

    Letts, Melinda

    2016-01-01

    Rufus of Ephesus' short treatise, Quaestiones Medicinales, the only ancient medical work that takes as its topic the dialogue between doctor and patient, has usually been seen as a procedural practical handbook serving an essentially operational purpose. In this paper I argue that the treatise, with its insistent message that doctors cannot properly understand and treat illnesses unless they supplement their own knowledge by questioning patients, and its remarkable appreciation of the singularity of each patient's experience, shows itself to be no mere handbook but a work addressing the place of questioning in the clinical encounter. I illustrate some of the differences between Rufus' conceptualisation of the relevance and use of questioning and that which can be seen in the theoretical and descriptive writings of Galen and in the Hippocratic corpus, and show how apparent resonances with some of the preoccupations of modern Western healthcare can be used judiciously to elucidate the significance of those differences. PMID:26946674

  10. "I didn't write the questions!" - Negotiating telephone-survey questions on birth timing

    Directory of Open Access Journals (Sweden)

    Marian May

    2008-06-01

    Full Text Available This paper examines interviewer-respondent interaction in the collection of demographic data. Conversation analysis (CA makes transparent the interaction between an interviewer and 25 respondents on a question about pregnancy and birth timing in an Australian telephone survey, Negotiating the Life Course. The analysis focuses on the troubles that occur and the work interviewers do to fit respondents' answers to the survey researcher's categories. Interviewers are shown to act as mediators in difficult interaction, with responses often distorted by question format, the imperative of achieving an allowed response, and the need to keep the respondent in the survey.

  11. Question Safari: Seeking Questions in Their Natural Habitat. A Case Report.

    Science.gov (United States)

    Lawson, Emily S

    2016-01-01

    Due to the demanding schedules of nurses, many clinical queries generated during patient care are forgotten before the nurse has time to conduct a search. This article describes a new clinical librarian service, Question Safari, created in partnership with the Nursing Research & Evidence-Based Practice initiative to help mitigate this issue and to support patient care. PMID:27054538

  12. Some open questions concerning biological growth

    Directory of Open Access Journals (Sweden)

    Escudero, Carlos

    2010-12-01

    Full Text Available We briefly review the properties of radially growing interfaces and their connection to biological growth. We focus on simplified models which result from the abstraction of only considering domain growth and not the interface curvature. Linear equations can be exactly solved and the phenomenology of growth can be inferred from the explicit solutions. Nonlinear equations pose interesting open questions that are summarized herein.

    En este trabajo revisamos brevemente las propiedades de las superficies que crecen de forma radial y su conexión con el crecimiento biológico. Nos vamos a concentrar en modelos simplificados que resultan de la abstracción de sólo considerar el crecimiento del dominio y no la curvatura de la interfaz. Las ecuaciones lineales se pueden resolver exactamente y la fenomenología del crecimiento puede ser inferida de las soluciones explítas. Las ecuaciones no lineales dan lugar a interesantes problemas abiertos que vamos a resumir aquí.

  13. Question Driven Instruction with Classroom Response Technology

    Science.gov (United States)

    Gerace, William; Beatty, Ian

    2007-10-01

    Essentially, a classroom response system is technology that: 1) allows an instructor to present a question or problem to the class; 2) allows students to enter their answers into some kind of device; and 3) instantly aggregates and summarizes students' answers for the instructor, usually as a histogram. Most response systems provide additional functionality. Some additional names for this class of system (or for subsets of the class) are classroom communication system (CCS), audience response system (ARS), voting machine system, audience feedback system, and--most ambitiously--CATAALYST system (for ``Classroom Aggregation Technology for Activating and Assessing Learning and Your Students' Thinking''). UMPERG has been teaching with and researching classroom response systems since 1993. We find that the technology has the potential to transform the way we teach science in large lecture settings. CRSs can serve as catalysts for creating a more interactive, student-centered classroom in the lecture hall, thereby allowing students to become more actively involved in constructing and using knowledge. CRSs not only make it easier to engage students in learning activities during lecture but also enhance the communication among students, and between the students and the instructor. This enhanced communication assists the students and the instructor in assessing understanding during class time, and affords the instructor the opportunity to devise instructional interventions that target students' needs as they arise.

  14. Open Educational Resources: American Ideals, Global Questions

    Directory of Open Access Journals (Sweden)

    Steven Weiland

    2015-09-01

    Full Text Available Educational relations between societies and cultures that begin with benevolent intentions can come to be seen as threats to national autonomy and local preferences. Indeed, side by side with the growth since the first years of this century of Open Educational Resources (OER there has been worry about their impact on global educational development. Evaluation and research have lagged behind the steady expansion of access to online resources, leaving estimates of the value of digital innovation to the enthusiasm of OER providers and technology minded educational reformers. The advent of the “Massive Open Online Course” (or MOOC has exacerbated the problem, with attention moving toward a form of OER reflecting the enthusiasm of leading institutions in industrialized nations. The American led movement on behalf of the MOOC requires new questions about the motives, impact, and future of OER. This essay accounts for the history of OER, culminating in the MOOC, including how the latter in particular is an expression of American pedagogical and institutional interests representing belief in the transformative educational powers of the latest communications technologies. Criticism of OER and MOOCs can reflect organizational, operational, and ideological considerations. But it should recognize what they offer when there are few other opportunities for formal learning, and as research demonstrates their uses and impact.

  15. The Question of Intersubjectivity in Zhuangzi

    Directory of Open Access Journals (Sweden)

    Agnieška Juzefovič

    2011-02-01

    Full Text Available The article deals with the question of intersubjectivity in Daoists’ treatise Zhuangzi and shows how in Daoism a skeptical approach towards rationality and reasonable, logical understanding is reflected in the very topic of inter-human understanding. The author argues that in Zhuangzi “self ” is treated as uncertain and contextual; thus, according to a situation, it can suddenly transform and take totally different features. A popular and often interpreted dialogue between Zhuangzi and his opponent Huizi about joy of the fish is analyzed from the point of view of intersubjectivity – the author shows how the possibility of mutual understanding between two interlocutors as well as between human being and the fish or the nature in general is treated. The author argues that intersubjective relation according to Zhuangzi is possible not on a rational or empirical level but on a deeper intuitive, empathetic level. Finally, the author shows how this topic is treated in western phenomenology and dialogical philosophy. 

  16. Morphological plasticity of bacteria-Open questions.

    Science.gov (United States)

    Shen, Jie-Pan; Chou, Chia-Fu

    2016-05-01

    Morphological plasticity of bacteria is a cryptic phenomenon, by which bacteria acquire adaptive benefits for coping with changing environments. Some environmental cues were identified to induce morphological plasticity, but the underlying molecular mechanisms remain largely unknown. Physical and chemical factors causing morphological changes in bacteria have been investigated and mostly associated with potential pathways linked to the cell wall synthetic machinery. These include starvation, oxidative stresses, predation effectors, antimicrobial agents, temperature stresses, osmotic shock, and mechanical constraints. In an extreme scenario of morphological plasticity, bacteria can be induced to be shapeshifters when the cell walls are defective or deficient. They follow distinct developmental pathways and transform into assorted morphological variants, and most of them would eventually revert to typical cell morphology. It is suggested that phenotypic heterogeneity might play a functional role in the development of morphological diversity and/or plasticity within an isogenic population. Accordingly, phenotypic heterogeneity and inherited morphological plasticity are found to be survival strategies adopted by bacteria in response to environmental stresses. Here, microfluidic and nanofabrication technology is considered to provide versatile solutions to induce morphological plasticity, sort and isolate morphological variants, and perform single-cell analysis including transcriptional and epigenetic profiling. Questions such as how morphogenesis network is modulated or rewired (if epigenetic controls of cell morphogenesis apply) to induce bacterial morphological plasticity could be resolved with the aid of micro-nanofluidic platforms and optimization algorithms, such as feedback system control. PMID:27375812

  17. Basic Physics Questions Addressed by Astrophysics

    Science.gov (United States)

    Mather, John C.

    2009-01-01

    Dark matter, dark energy, the Big Bang, testing relativity -- all are physics questions accessible to astrophysicists -- but all require new equipment. As Harwit's "Cosmic Discovery" pointed out, almost all great surprises in astronomy came from new equipment or new uses of equipment designed for other purposes, and many of those had military applications. I will outline prospects for new equipment and discuss how that equipment can be developed and built. Bigger and lighter mirrors, wavefront sensing and control, new detector technology, cryogenics -- each has its own social network, its own special possibilities, and its own funding sources outside science. I will discuss some examples drawn from real-life experience with the James Webb Space Telescope, a telescope that was said to have a "giggle factor" when it was proposed in 1995. Now each of the 10 major technologies has been brought to maturity, flight hardware is being built, and launch is planned for 2014. As an instrument builder all my life, I will speculate a little on what may be within our reach over the next few decades.

  18. The Question of Metropolitan Form: Introduction

    Directory of Open Access Journals (Sweden)

    Anne Vernez Moudon

    2009-11-01

    Full Text Available Posing the concept of ‘metropolitan form’ as a question, as in the call for papers for this issue of Footprint, is an absolute necessity at this stage of development of urbanised areas. Many of the papers in this issue begin with the straw-man notion of a formless agglomeration of activities and spaces, the – for lack of a better phrase – postmodern urban experience.[1] There is a persistent theme in the related literatures of architecture, urban design and urban and regional planning that the physical form of the contemporary metropolis is un-describable. Soja’s six metaphors (post-Fordist industrial, cosmopolis, expolis, fractal city, carceral archipelago, simcities are being indicative of the wide range of possible images.[2] The eight papers in this issue of Footprint take an opposite approach. They begin to trace the contours of the debate around how the noun ‘metropolitan form’ might be understood, how it might be studied, and how it might be possible to move from an empirical understanding of its structure to more intuitive design solutions.

  19. Discovery Mondays - Mass: a question of weight?

    CERN Multimedia

    2006-01-01

    Mass and weight: two rather commonplace phenomena on the surface of it, but would you be able to explain the difference between them? And do you know how gravity works? If you let go of a paperclip and an apple at the same time, which of the two will hit the floor first? At the next Discovery Monday scientists will introduce you to these concepts that are often rather difficult to get to grips with. Find out what kind of particles are thought to be responsible for mass and gravity. Get to know the graviton, a particle that has yet to be observed, has no mass or charge but is thought to be a messenger particle for gravity. You will also encounter the famous Higgs boson, which scientists believe could elucidate the mystery of mass and hope to discover with the LHC. An evening for tackling some very weighty questions... The event will be conducted in French. Join us at Microcosm (Reception, Building 33, Meyrin site), on Monday 6 March from 7.30 p.m. to 9.00 p.m. Entrance Free http://www.cern.ch/LundisDeco...

  20. Long Period Variables: questioning the pulsation paradigm

    CERN Document Server

    Berlioz-Arthaud, Paul

    2016-01-01

    Long period variables, among them Miras, are thought to be pulsating. Under this approach the whole star inflates and deflates along a period that can vary from 100 to 900 days; that pulsation is assumed to produce shock waves on the outer layers of the star that propagate into the atmosphere and could account for the increase in luminosity and the presence of emission lines in the spectra of these stars. However, this paradigm can seriously be questioned from a theoretical point of view. First, in order to maintain a radial pulsation, the spherical symmetry of the star must be preserved: how can it be reconciled with the large convective cells present in these stars? or when close companions are detected? Secondly, how different radial and non-radial pulsation modes of a sphere could be all damped except one radial mode? These problems have no solution and significantly weigh on the pulsation paradigm. Acknowledging this inconsistency, we show that a close companion around these stars could account for the s...

  1. Writing Effective Online Homework Questions for Astro 101

    Science.gov (United States)

    Urban, A.

    2014-07-01

    The online environment provides benefits and limitations to the scope and implementation of homework questions. In this session we discussed this topic, as well as the methodology used to write effective computer-graded online homework questions, specifically discussing targeted feedback and randomization. I demonstrated a few existing online astronomy questions and then workshop participants worked in groups to write their own questions. We concluded with a discussion of effective strategies for writing online homework questions. We focused on developing and writing questions within an environment that includes randomization and targeted feedback, similar to Sapling Learning, MasteringAstronomy, and WebAssign.

  2. Rainfall Simulation: methods, research questions and challenges

    Science.gov (United States)

    Ries, J. B.; Iserloh, T.

    2012-04-01

    In erosion research, rainfall simulations are used for the improvement of process knowledge as well as in the field for the assessment of overland flow generation, infiltration, and erosion rates. In all these fields of research, rainfall experiments have become an indispensable part of the research methods. In this context, small portable rainfall simulators with small test-plot sizes of one square-meter or even less, and devices of low weight and water consumption are in demand. Accordingly, devices with manageable technical effort like nozzle-type simulators seem to prevail against larger simulators. The reasons are obvious: lower costs and less time consumption needed for mounting enable a higher repetition rate. Regarding the high number of research questions, of different fields of application, and not least also due to the great technical creativity of our research staff, a large number of different experimental setups is available. Each of the devices produces a different rainfall, leading to different kinetic energy amounts influencing the soil surface and accordingly, producing different erosion results. Hence, important questions contain the definition, the comparability, the measurement and the simulation of natural rainfall and the problem of comparability in general. Another important discussion topic will be the finding of an agreement on an appropriate calibration method for the simulated rainfalls, in order to enable a comparison of the results of different rainfall simulator set-ups. In most of the publications, only the following "nice" sentence can be read: "Our rainfall simulator generates a rainfall spectrum that is similar to natural rainfall!". The most substantial and critical properties of a simulated rainfall are the drop-size distribution, the fall velocities of the drops, and the spatial distribution of the rainfall on the plot-area. In a comparison of the most important methods, the Laser Distrometer turned out to be the most up

  3. Medical marijuana: more questions than answers.

    Science.gov (United States)

    Hill, Kevin P

    2014-09-01

    With 23 states and the District of Columbia having enacted medical marijuana laws as of August 2014, it is important that psychiatrists be able to address questions about medical marijuana from patients, families, and other health care professionals. The author discusses the medical literature on synthetic cannabinoids and medical marijuana. The synthetic cannabinoids dronabinol and nabilone are approved by the United States Food and Drug Administration for nausea and vomiting associated with cancer chemotherapy and appetite stimulation in patients with wasting diseases such as acquired immunodeficiency syndrome (AIDS). Results of clinical trials of these agents for other conditions have varied widely thus far. In addition, few data are available on the use of the marijuana plant as a medical treatment. The author concludes that there is a clear need for additional research on possible medical uses of cannabinoids. He notes that discussions with prospective medical marijuana patients should emphasize the importance of communication among all parties due to the possible side effects of treatment with marijuana and its potential to interact with other medications the patient may be taking. Facilitating a thorough substance abuse consultation is one of most positive ways that psychiatrists, especially addiction psychiatrists, can make an impact as medical marijuana becomes increasingly common. A careful review of the prospective medical marijuana user's substance use history, co-occurring medical and psychiatric conditions, family history, and psychosocial stressors is essential in evaluating the potential risks of medical marijuana for these patients. The author concludes that psychiatrists can have a significant impact by increasing the likelihood that medical marijuana will be used in a safe and responsible way. PMID:25226202

  4. Icelandic Journalists & the Question of Professionalism

    Directory of Open Access Journals (Sweden)

    Birgir Guðmundsson

    2015-03-01

    Full Text Available The question whether journalism constitutes a profession or not has been widely discussed in the literature in recent decades without a definite conclusion. Indeed some suggest that much of the contradictory views on professionalism and the professionalization of journalism may be traced to the unclear meaning of the very term “professionalism” or “professionalization” (Nolan 2008. Thus it is possible to put simultaneously forth plausible arguments suggesting de-professionalization of journalism on the one hand, and further professionalization of journalism on the other, based on different interpretations of the term “professionalism”. The terms “professional” and “professionalism” can refer to different social phenomena in different contexts. Thus an ongoing professionalization of journalism can be taking place in one sense at the same time as de-professionalization in a different sense, and of course, these different trends can also be taking place simultaneously in different parts of the media environment (Nolan, 2008; Hallin&Mancini, 2004; Witschge&Nygren, 2009; Schudson, 2001. In determining an approach to the concept of a profession it is helpful to establish some general criteria, against which journalistic practice may be measured. In finding these criteria, guidelines are given by the discussion of traditional professions - doctors, lawyers – and on that basis some characteristics can been said to signify a profession. To what extent is the work of Icelandic journalists characterised by professionalism, and to what extent do they, as an occupational group, exhibit the features normally associated with professions? The following analysis suggests that Icelandic journalists fulfil many of the key conditions associated with professions and their development in recent decades has been one of increased professionalism.

  5. Questioning Strategies of Literature Teachers among Grade 8 Filipino Students

    Directory of Open Access Journals (Sweden)

    Magdalena M. Ocbian

    2015-11-01

    Full Text Available Questioning is a useful and relevant tool to facilitate classroom discussion in a literature class. This study identified the levels of questions teachers use in their literature class, determined the different question strategies they utilized and proposed activities to enhance the questioning strategies of literature teachers. Video analysis was the main instrument used. These videos were provided during the conduct of class observations by the researchers. There were eight respondents in the study selected through total enumeration. They are teachers from Gubat Cluster of secondary schools of Sorsogon Province. To identify the levels of questions and questioning strategies, question tally form and percentage were used. Results revealed that knowledge was the most used level of questions followed by comprehension, application, analysis, synthesis and evaluation. The most used question technique is the participation, followed by proving, sequencing, wait time, balance and student questions. It was recommended that literature teachers vary their level of questions when discussing literary pieces. They may utilize different question techniques to develop critical thinking skills of their students. The use of the proposed activities may enhance the questioning strategies of literature teachers. Likewise, school heads and program supervisors may utilize video analysis technique as a mode for classroom observation.

  6. A Comparative Analysis Between TIMSS-R (1999) Questions and LGS (1999) Questions in Life Science

    OpenAIRE

    AFACAN, Özlem; Nuhoğlu, Hasret

    2008-01-01

    The association made international evaluation in education field (IEA), matches the countries wanted to be added in science and mathematics field with examination doing every four years. This examination applied third times in 1999 and Turkey attended to it first time.This research is a quality methods including survey models. The aim of this research is to compare between LGS and TIMSS-R questions about subject of life science and to interpret their questions’ content. These questions’ analy...

  7. Assessing the quality of a student-generated question repository

    CERN Document Server

    Bates, Simon P; Homer, Danny; Riise, Jonathan

    2013-01-01

    We present results from a study that categorizes and assesses the quality of questions and explanations authored by students, in question repositories produced as part of the summative assessment in introductory physics courses over the past two years. Mapping question quality onto the levels in the cognitive domain of Bloom's taxonomy, we find that students produce questions of high quality. More than three-quarters of questions fall into categories beyond simple recall, in contrast to similar studies of student-authored content in different subject domains. Similarly, the quality of student-authored explanations for questions was also high, with approximately 60% of all explanations classified as being of high or outstanding quality. Overall, 75% of questions met combined quality criteria, which we hypothesize is due in part to the in-class scaffolding activities that we provided for students ahead of requiring them to author questions.

  8. Answers to Your Questions about Transgender Individuals and Gender Identity

    Science.gov (United States)

    ... Questions for a Better Understanding of Sexual Orientation & Homosexuality for more information on sexual orientation). The degree ... questions for a better understanding of sexual orientation & homosexuality. Retrieved from http: / / www. apa. org/ topics/ lgbt/ ...

  9. Inferring protein inverted question markprotein interaction complexes from immunoprecipitation data

    NARCIS (Netherlands)

    J. Kutzera; H.C.J. Hoefsloot; A. Malovannaya; A.B. Smit; I. van Mechelen; A.K. Smilde

    2013-01-01

    BACKGROUND: Protein inverted question markprotein interactions in cells are widely explored using small inverted question markscale experiments. However, the search for protein complexes and their interactions in data from high throughput experiments such as immunoprecipitation is still a challenge.

  10. Questioning the Question: How can a husband rape his wife? : A Discussion in an International Classroom

    Directory of Open Access Journals (Sweden)

    Anjali Nicole Walquist

    2015-03-01

    Full Text Available This essay discusses the question “How can a husband rape his wife?” I assume that upon reading this you already have some reaction or answer. I have one, too. The interesting part is that they can be very different. Some people think along the lines of “Yes, I can't imagine how a husband can rape his wife because that is so cruel.” Other people may think something like “Yes, how is this even possible, that a husband having sex with his wife could be considered rape.” These views are quite different, and it is this difference that interests me.In this essay, I will reflect upon the question “How can a husband rape his wife?” I will discuss my personal background, and describe the situation and experience in which this question was brought up. Next, I will discuss various reflections I have had about this difference. I will then reflect on how this idea, or even the definitions of the terms, may be based on a person’s culture, gender, and/or opinions. After that, I will look at how this topic may affect social workers, service users and social work as a profession. Lastly, I will also explain how this has helped me gain a better understanding of this issue.

  11. Structural-communicative types of the perplexed echo question

    OpenAIRE

    VOROBYOVA ELENA N.

    2015-01-01

    Modern linguistics has shown us that the language is not limited to questions with the standard semantics of interrogation. Among the interrogative sentences used in the secondary functions one can find inquiries with additional emotional colourings. Perplexity is the closest emotional evaluative meaning, accompanying the interrogative semantics of a question. In the paper, one of the structural-communicative types of the perplexed question (an echo question) is considered. Two structural typ...

  12. Questions related to Bitcoin and other Informational Money

    OpenAIRE

    Bergstra, J. A.; Leeuw, van der, R.

    2013-01-01

    A collection of questions about Bitcoin and its hypothetical relatives Bitguilder and Bitpenny is formulated. These questions concern technical issues about protocols, security issues, issues about the formalizations of informational monies in various contexts, and issues about forms of use and misuse. Some questions are formulated in the more general setting of informational monies and near-monies. We also formulate questions about legal, psychological, and ethical aspects of informational m...

  13. How to enhance students' questioning ability in English reading?

    Institute of Scientific and Technical Information of China (English)

    陆学聃

    2006-01-01

    @@ A student's thinking usually starts from questions. In English teaching, it's an important part of the teacher's work to guide the students to question. When read a new article, the students may have questions about words, phrases, sentences, grammar, structure, motif, etc. To encourage students to raise questions in reading is a good way to help students enhance their interest in English and improve their ability of self-study.

  14. Identifying the big question in international business research

    OpenAIRE

    Mike W. Peng

    2004-01-01

    Buckley (2002) argues that the international business (IB) research agenda may be running out of steam, because no big research question has currently been identified. Buckley also asks whether the field needs a big question, and if so challenges IB scholars to discover it. Buckley and Ghauri (2004) elaborate on the third question of globalization discussed in Buckley (2002) as a possible candidate for the big question. In response, this article is written to take up Buckley's challenge and a...

  15. Circulations of Law: Colonial Precedents, Contemporary Questions

    Directory of Open Access Journals (Sweden)

    Iza Hussin

    2012-12-01

    Full Text Available While the project of law-making has seemed an obvious and inherent part of empire-building, and law-delivery has often been a justifying rationale for imperialism, this paper asks more detailed questions about the travels of law. How is a ‘universal’ law made ‘local’, and to what effect? How have past and contemporary legal delivery projects delineated between the categories of local and universal? Our analytic project, therefore, is not simply that law travels, but with whom; not just that it is carried, but alongside what other commodities and baggage; not just that it moves, but that it is transformed by its passage across borders and among localities. Further, whereas much of rule of law and imperial law scholarship sees legal travel as from metropole to colony, this paper argues that ports of call are equally important for the fate of law. Aunque el proyecto de legislación parecía una parte obvia e inherente al proceso de construcción del imperio, y la creación de leyes ha sido a menudo una justificación para el imperialismo, este artículo lanza preguntas más detalladas sobre los recorridos del derecho. ¿Cómo se convierte una ley “universal” en “local”, y qué efectos conlleva? ¿Cómo han diferenciado entre las categorías “local” y “universal” los proyectos de legislación pasados y contemporáneos? Así pues, nuestro proyecto analítico no concluye simplemente que la ley tiene un recorrido, sino con quién; no simplemente que es transportada, sino con qué otras comodidades y equipaje; no sólo que se mueve, sino que se transforma en su viaje a través de límites y localizaciones. Es más, mientras que gran parte de la comunidad científica del estado del derecho y el imperio del derecho ve que las leyes van de la metrópoli a la colonia, este artículo defiende que las escalas que realiza son igual de importantes para el destino del derecho. DOWNLOAD THIS PAPER FROM SSRN: http

  16. 10 CFR 709.12 - Defining polygraph examination questions.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Defining polygraph examination questions. 709.12 Section... Protection of National Security § 709.12 Defining polygraph examination questions. The examiner determines the exact wording of the polygraph questions based on the examiner's pretest interview of the...

  17. A Support System for Error Correction Questions in Programming Education

    Science.gov (United States)

    Hachisu, Yoshinari; Yoshida, Atsushi

    2014-01-01

    For supporting the education of debugging skills, we propose a system for generating error correction questions of programs and checking the correctness. The system generates HTML files for answering questions and CGI programs for checking answers. Learners read and answer questions on Web browsers. For management of error injection, we have…

  18. Fostering Effective Studying and Study Planning with Study Questions

    Science.gov (United States)

    Wilhelm, Pascal; Pieters, Jules M.

    2007-01-01

    In a course on biological psychology and neuropsychology, study questions were provided that also appeared as test questions in the course exam. This method was introduced to support students in active processing and reproduction of the study texts, and study planning. Data were gathered to test the hypothesis that study question use would be…

  19. Improving the Questioning Strategies of Learning Disabled Children.

    Science.gov (United States)

    Freund, Lisa Ann

    1988-01-01

    The effects of two instructional methods on the questioning strategies of 40 10- to 12-year-old learning disabled children were investigated. Results indicated that both the question formulation instruction and the cognitive modeling/self-verbalization instruction were effective in improving their questioning concerning novel problems. (Author/DB)

  20. Exploration of question intonation in read American English

    Science.gov (United States)

    Syrdal, Ann K.; Jilka, Matthias

    2003-10-01

    Several generally accepted intonational features of questions in American English have not been the subject of much empirical study: namely that wh-questions end in L-L% phrasal accents, and that their intonational contours are identical to those of declarative sentences, while yes/no questions end in H-H% phrasal accents. The study addresses the following questions about question intonation: How frequently do yes/no questions end in H-H% phrasal tones, and how often do wh-questions end in L-L% phrasal tones? How similar are the intonational contours and features of declarative sentences and wh-questions with phrase-final falls (L-L%)? How do the sentence pitch ranges of yes/no questions, wh-questions, and declarative sentences compare? Does a speaker's characteristic pitch range affect the character or frequency of occurrence of question phrasal-tones? Speaker and utterance pitch ranges and their relation to prosodic features of pitch accents and phrasal tones were observed in yes/no and in wh-questions, and compared to a sample of simple declarative sentences spoken by the same speakers: 5 female and 3 male American English professional voice talents. The same set of 12 sentences were read by each of the 8 speakers in the same contexts. Theoretical and practical implications of the results will be discussed.

  1. Plasminogen-based capture combined with amplification technology for the detection of PrP(TSE in the pre-clinical phase of infection.

    Directory of Open Access Journals (Sweden)

    Christiane Segarra

    Full Text Available BACKGROUND: Variant Creutzfeldt-Jakob disease (vCJD is a neurodegenerative infectious disorder, characterized by a prominent accumulation of pathological isoforms of the prion protein (PrP(TSE in the brain and lymphoid tissues. Since the publication in the United Kingdom of four apparent vCJD cases following transfusion of red blood cells and one apparent case following treatment with factor VIII, the presence of vCJD infectivity in the blood seems highly probable. For effective blood testing of vCJD individuals in the preclinical or clinical phase of infection, it is considered necessary that assays detect PrP(TSE concentrations in the femtomolar range. METHODOLOGY/PRINCIPAL FINDINGS: We have developed a three-step assay that firstly captures PrP(TSE from infected blood using a plasminogen-coated magnetic-nanobead method prior to its serial amplification via protein misfolding cyclic amplification (PMCA and specific PrP(TSE detection by western blot. We achieved a PrP(TSE capture yield of 95% from scrapie-infected material. We demonstrated the possibility of detecting PrP(TSE in white blood cells, in buffy coat and in plasma isolated from the blood of scrapie-infected sheep collected at the pre-clinical stage of the disease. The test also allowed the detection of PrP(TSE in human plasma spiked with a 10(-8 dilution of vCJD-infected brain homogenate corresponding to the level of sensitivity (femtogram required for the detection of the PrP(TSE in asymptomatic carriers. The 100% specificity of the test was revealed using a blinded panel comprising 96 human plasma samples. CONCLUSION/SIGNIFICANCE: We have developed a sensitive and specific amplification assay allowing the detection of PrP(TSE in the plasma and buffy coat fractions of blood collected at the pre-clinical phase of the disease. This assay represents a good candidate as a confirmatory assay for the presence of PrP(TSE in blood of patients displaying positivity in large scale screening

  2. Finding Question-Answer Pairs from Online Forums

    DEFF Research Database (Denmark)

    Cong, Gao; Wang, Long; Lin, Chin-Yew;

    2008-01-01

    Online forums contain a huge amount of valuable user generated content. In this paper we address the problem of extracting question-answer pairs from forums. Question-answer pairs extracted from forums can be used to help Question Answering services (e.g. Yahoo! Answers) among other applications........ We propose a sequential patterns based classification method to detect questions in a forum thread, and a graph based propagation method to detect answers for questions in the same thread. Experimental results show that our techniques are very promising....

  3. Examining the Impact of Question Surface Features on Students' Answers to Constructed-Response Questions on Photosynthesis

    Science.gov (United States)

    Weston, Michele; Haudek, Kevin C.; Prevost, Luanna; Urban-Lurain, Mark; Merrill, John

    2015-01-01

    One challenge in science education assessment is that students often focus on surface features of questions rather than the underlying scientific principles. We investigated how student written responses to constructed-response questions about photosynthesis vary based on two surface features of the question: the species of plant and the order of…

  4. Designing Effective Questions for Classroom Response System Teaching

    CERN Document Server

    Beatty, I D; Gerace, W J

    2005-01-01

    Classroom response systems (CRSs) can be potent tools for teaching physics. Their efficacy, however, depends strongly on the quality of the questions used. Creating effective questions is difficult, and differs from creating exam and homework problems. Every CRS question should have an explicit pedagogic purpose consisting of a content goal, a process goal, and a metacognitive goal. Questions can be engineered to fulfil their purpose through four complementary mechanisms: directing students' attention, stimulating specific cognitive processes, communicating information to instructor and students via CRS-tabulated answer counts, and facilitating the articulation and confrontation of ideas. We identify several tactics that help in the design of potent questions, and present four "makeovers" showing how these tactics can be used to convert traditional physics questions into more powerful CRS questions.

  5. Questioning the Question: How can a husband rape his wife? : A Discussion in an International Classroom

    OpenAIRE

    Anjali Nicole Walquist

    2015-01-01

    This essay discusses the question “How can a husband rape his wife?” I assume that upon reading this you already have some reaction or answer. I have one, too. The interesting part is that they can be very different. Some people think along the lines of “Yes, I can't imagine how a husband can rape his wife because that is so cruel.” Other people may think something like “Yes, how is this even possible, that a husband having sex with his wife could be considered rape.” These views are quite di...

  6. Comparison of integrated testlet and constructed-response question formats

    Science.gov (United States)

    Slepkov, Aaron D.; Shiell, Ralph C.

    2014-12-01

    Constructed-response (CR) questions are a mainstay of introductory physics textbooks and exams. However, because of the time, cost, and scoring reliability constraints associated with this format, CR questions are being increasingly replaced by multiple-choice (MC) questions in formal exams. The integrated testlet (IT) is a recently developed question structure designed to provide a proxy of the pedagogical advantages of CR questions while procedurally functioning as set of MC questions. ITs utilize an answer-until-correct response format that provides immediate confirmatory or corrective feedback, and they thus allow not only for the granting of partial credit in cases of initially incorrect reasoning, but, furthermore, the ability to build cumulative question structures. Here, we report on a study that directly compares the functionality of ITs and CR questions in introductory physics exams. To do this, CR questions were converted to concept-equivalent ITs, and both sets of questions were deployed in midterm and final exams. We find that both question types provide adequate discrimination between stronger and weaker students, with CR questions discriminating slightly better than the ITs. There is some indication that any difference in discriminatory power may result from the baseline score for guessing that is inherent in MC testing. Meanwhile, an analysis of interrater scoring of the CR questions raises serious concerns about the reliability of the granting of partial credit when this traditional assessment technique is used in a realistic (but nonoptimized) setting. Furthermore, we show evidence that partial credit is granted in a valid manner in the ITs. Thus, together with consideration of the vastly reduced costs of administering IT-based examinations compared to CR-based examinations, our findings indicate that ITs are viable replacements for CR questions in formal examinations where it is desirable both to assess concept integration and to reward partial

  7. Analysis of questioning technique during classes in medical education

    Directory of Open Access Journals (Sweden)

    Cho Young

    2012-06-01

    Full Text Available Abstract Background Questioning is one of the essential techniques used by lecturers to make lectures more interactive and effective. This study surveyed the perception of questioning techniques by medical school faculty members and analyzed how the questioning technique is used in actual classes. Methods Data on the perceptions of the questioning skills used during lectures was collected using a self‒questionnaire for faculty members (N = 33 during the second semester of 2008. The questionnaire consisted of 18 items covering the awareness and characteristics of questioning skills. Recorded video tapes were used to observe the faculty members’ questioning skills. Results Most faculty members regarded the questioning technique during classes as being important and expected positive outcomes in terms of the students’ participation in class, concentration in class and understanding of the class contents. In the 99 classes analyzed, the median number of questions per class was 1 (0–29. Among them, 40 classes (40.4 % did not use questioning techniques. The frequency of questioning per lecture was similar regardless of the faculty members’ perception. On the other hand, the faculty members perceived that their usual wait time after question was approximately 10 seconds compared to only 2.5 seconds measured from video analysis. More lecture‒experienced faculty members tended to ask more questions in class. Conclusions There were some discrepancies regarding the questioning technique between the faculty members’ perceptions and reality, even though they had positive opinions of the technique. The questioning skills during a lecture need to be emphasized to faculty members.

  8. IMPROVISATION OF SEEKER SATISFACTION IN YAHOO! COMMUNITY QUESTION ANSWERING PORTAL

    Directory of Open Access Journals (Sweden)

    K. Latha

    2011-01-01

    Full Text Available One popular Community question answering (CQA site, Yahoo! Answers, had attracted 120 million users worldwide, and had 400 million answers to questions available. A typical characteristic of such sites is that they allow anyone to post or answer any questions on any subject. Question Answering Community has emerged as popular, and often effective, means of information seeking on the web. By posting questions, for other participants to answer, information seekers can obtain specific answers to their questions. However, CQA is not always effective: in some cases, a user may obtain a perfect answer within minutes, and in others it may require hours and sometimes days until a satisfactory answer is contributed. We investigate the problem of predicting information seeker satisfaction in yahoo collaborative question answering communities, where we attempt to predict whether a question author will be satisfied with the answers submitted by the community participants. Our experimental results, obtained from a large scale evaluation over thousands of real questions and user ratings, demonstrate the feasibility of modeling and predicting asker satisfaction. We complement our results with a thorough investigation of the interactions and information seeking patterns in question answering communities that correlate with information seeker satisfaction. We also explore automatic ranking, creating abstract from retrieved answers, and history updation, which aims to provide users with what they want or need without explicitly ask them for user satisfaction. Our system could be useful for a variety of applications, such as answer selection, user feedback analysis, and ranking.

  9. Multi-Factor Duplicate Question Detection in Stack Overflow

    Institute of Scientific and Technical Information of China (English)

    张芸; David Lo; 夏鑫; 孙建伶

    2015-01-01

    Stack Overflow is a popular on-line question and answer site for software developers to share their experience and expertise. Among the numerous questions posted in Stack Overflow, two or more of them may express the same point and thus are duplicates of one another. Duplicate questions make Stack Overflow site maintenance harder, waste resources that could have been used to answer other questions, and cause developers to unnecessarily wait for answers that are already available. To reduce the problem of duplicate questions, Stack Overflow allows questions to be manually marked as duplicates of others. Since there are thousands of questions submitted to Stack Overflow every day, manually identifying duplicate questions is a di昋cult work. Thus, there is a need for an automated approach that can help in detecting these duplicate questions. To address the above-mentioned need, in this paper, we propose an automated approach named DUPPREDICTOR that takes a new question as input and detects potential duplicates of this question by considering multiple factors. DUPPREDICTOR extracts the title and description of a question and also tags that are attached to the question. These pieces of information (title, description, and a few tags) are mandatory information that a user needs to input when posting a question. DUPPREDICTOR then computes the latent topics of each question by using a topic model. Next, for each pair of questions, it computes four similarity scores by comparing their titles, descriptions, latent topics, and tags. These four similarity scores are finally combined together to result in a new similarity score that comprehensively considers the multiple factors. To examine the benefit of DUPPREDICTOR, we perform an experiment on a Stack Overflow dataset which contains a total of more than two million questions. The result shows that DUPPREDICTOR can achieve a recall-rate@20 score of 63.8%. We compare our approach with the standard search engine of Stack

  10. Setting generalization of question-asking by children with autism.

    Science.gov (United States)

    Koegel, L K; Camarata, S M; Valdez-Menchaca, M; Koegel, R L

    1998-01-01

    We examined whether motivational procedures incorporated into teaching question-asking to children with autism, who lack verbal initiations, would result in generalization without additional teaching, prompting, or reinforcement in other settings. Specifically, we assessed whether such children could learn to use questions and whether the spontaneous use of question-asking would generalize across stimuli, settings, and people. All children learned to use questions in relation to items they had previously been unable to label and demonstrated generalization of spontaneous question-asking to new items and to their home environments with their mothers, with concomitant gains in expressive vocabulary. Results were discussed in terms of teaching response strategies, such as question-asking, to promote spontaneous child-initiated social interactions and expressive language development.

  11. Comparative assessment of multiple choice questions versus short essay questions in pharmacology examinations

    Directory of Open Access Journals (Sweden)

    A Momin Mujeeb

    2010-01-01

    Full Text Available This retrospective study compared the performance of medical students in multiple choice questions (MCQs and short essay questions (SEQs. During the 3 year analysis, 533 students had an average score of 51.34% (SD 9.9 in the SEQ and 64.71%(SD 9.9in the MCQs. Regression analysis showed a significant correlation(r=0.64, P<0.01 between MCQs and SEQs. When student performance was grouped by final course grade, a statistically significant correlation between MCQs and SEQs scores existed only for the 405 students who received a passing grade (r=0.21, P<0.01. The MCQ and SEQ scores were not correlated for the 128 students who failed (r=0.11, P=0.08 or for 70 students who achieved distinctions (r=-0.27, P=0.13. MCQ scores were significantly higher (P<0.01 than SEQ for each of the groups when analyzed by the two-way ANOVA test. The result of this study suggests that for most students, the strong correlation between MCQ and SEQ indicates that student performance was independent of testing format. For students at either end of the performance spectrum, the lack of correlation suggests that the performance in one of the testing format had a strong influence on the final course grade. In addition, those students who failed the course were likely to be weak in both testing modalities, whereas students in all grade groups were more likely to perform better in the MCQs than SEQs.

  12. A Psycholinguistic Look at Survey Question Design and Response Quality

    OpenAIRE

    Lenzner, Timo

    2011-01-01

    It is universally acknowledged that the wording of a survey question can have a strong influence on the answers that respondents provide. For example, many studies have shown that vague and ambiguous terms are often interpreted idiosyncratically by respondents, and thus can increase measurement error. In addition to ambiguity, the cognitive effort required to comprehend survey questions may affect data quality in a similar way. This aspect of survey question design has received comparatively...

  13. [The sanitary question in the modernity-postmodernity debate].

    Science.gov (United States)

    Iriart, C; Spinelli, H

    1994-12-01

    This work analyzes the sanitary question in the modernity-postmodernity debate. Such analyses are performed form a philosophical position that states the crisis of Modernity and questions the ideological twist that to itself propitiates postmodernity, shutting out questioning views or visions. It propitiates an alternative view of politics, thinking of it from the potency plane and giving a role to the subject in the decision of producing transformations.

  14. Reference Question Data Mining A Systematic Approach to Library Outreach

    OpenAIRE

    Finnell, Joshua

    2010-01-01

    This exploratory study investigates the feasibility of using reference questions as an important tool in the construction of study guides, instructional outreach, and collection development at a small, four-year university in Lake Charles, Louisiana. The premise for the study is based on the assumption that the content of the reference question and class from which the question comes provides more valuable information than the metadata normally captured within reference classification systems...

  15. Question Waves: A multicast query routing algorithm for social search

    OpenAIRE

    Trias Mansilla, Albert; Rosa, Josep Lluís de la

    2013-01-01

    This paper describes Question Waves, an algorithm that can be applied to social search protocols, such as Asknext or Sixearch. In this model, the queries are propagated through the social network, with faster propagation through more trustable acquaintances. Question Waves uses local information to make decisions and obtain an answer ranking. With Question Waves, the answers that arrive first are the most likely to be relevant, and we computed the correlation of answer relevance with the orde...

  16. On the Analysis of Tag Questions in English Teaching

    Institute of Scientific and Technical Information of China (English)

    朱虹

    2013-01-01

    Tag question is often used in English conversation, but it is also a very complicated syntactic structure in English which becomes the difficulty of English learners. Tag question involves various grammatical factors. A full linguistic analysis of tag ques⁃tions includes the classification, construction and meanings of intonations of the tag questions in English. The study of tag ques⁃tion aims at providing substantial contribution to the teaching and learning of English syntax.

  17. Wh-interrogative formats used for questioning and beyond

    DEFF Research Database (Denmark)

    Egbert, Maria; Vöge, Monika

    2008-01-01

    This paper contributes to a critical discussion of how ‘question' and ‘questioning' may be defined in terms of form and function by analyzing the interactional usage of two apparently synonymous ‘question' words, German warum (why) and wieso (why) and their common English translation why. Warum a...... institutionality. In business meetings, there is a correlation between the occurrence of the complaint-implicative warum and the leadership status of the speaker in the team....

  18. Asking gender questions: Results from a survey of gender and question asking among UK Astronomers at NAM2014

    CERN Document Server

    Pritchard, Jonathan; Allen, James; Contenta, Filippo; Huckvale, Leo; Wilkins, Stephen; Zocchi, Alice

    2014-01-01

    We report on a survey of astronomers asking questions at the most recent National Astronomy Meeting (NAM2014). The gender balance of both speakers and session chairs at NAM (31% and 29% women respectively) closely matched that of attendees (28% female). However, we find that women were under-represented among question askers (just 18% female). Women were especially under-represented in asking the first question (only 14% of first questions asked by women), but when the Q&A session reached four or more questions, women and men were observed to ask roughly equal numbers of questions. We found a small, but statistically insignificant, increase in the fraction of questions from women in sessions where the chair was also female. On average $2.2\\pm0.1$ questions were asked per talk, with no detectable difference in the number of questions asked of female and male speakers, but on average female chairs solicited slightly fewer questions than male chairs. We compare these results to a similar study by Davenport e...

  19. Measuring questions: relevance and its relation to entropy

    CERN Document Server

    Knuth, K H

    2004-01-01

    The Boolean lattice of logical statements induces the free distributive lattice of questions. Inclusion on this lattice is based on whether one question answers another. Generalizing the zeta function of the question lattice leads to a valuation called relevance or bearing, which is a measure of the degree to which one question answers another. Richard Cox conjectured that this degree can be expressed as a generalized entropy. With the assistance of yet another important result from Janos Aczel, I show that this is indeed the case, and that the resulting inquiry calculus is a natural generalization of information theory. This approach provides a new perspective on the Principle of Maximum Entropy.

  20. Comprehension of wh-questions in two Broca's aphasics.

    Science.gov (United States)

    Hickok, G; Avrutin, S

    1996-02-01

    This study investigated comprehension of wh-questions in two Broca's aphasics. Patients were presented for comprehension with two types of wh-questions: questions headed by which and questions headed by who. These two types were chosen because according to recent syntactic analyses they give rise to different types of syntactic "chains." These questions were presented in both subject gap versions (e.g., which cat chased the dog?) and object gap versions (e.g., which cat did the dog chase?). Comprehension of which questions was asymmetric, with subject gap versions comprehended significantly better than object gap versions, the latter yielding chance-level performance. This finding is consistent with previous reports of subject-object asymmetries in comprehension of relative clauses and clefts, as well as active-passive comprehension asymmetries. In contrast, comprehension of who questions was symmetrical over subject gap and object gap versions: Both patients performed equally well (significantly better than chance) on subject gap and object gap who questions. These findings are inconsistent with current formulations of "chain" or "trace"-based theories of agrammatic comprehension which assume a deficit that affects both types of syntactic chains. We suggest that linguistic descriptions of agrammatic comprehension should be limited to deficits involving only one type of chain. We also suggest that there are processing differences underlying the syntactic distinctions between which-type and who-type questions and that this may account for different patterns of comprehension on these and other constructions. PMID:8811962

  1. Question intonation in non-scripted Danish dialogues

    DEFF Research Database (Denmark)

    Grønnum, Nina; Tøndering, John

    2007-01-01

    Global intonation contour slopes in read speech have been found to vary systematically according to utterance type. Statements have the steepest gradients, wh-question contours are slightly less steep, questions with word order inversion less steeply falling again, and so-called declarative...... questions have no gradient at all, i.e. their global contour is level. Furthermore, in all but the very shortest utterances onset and offset of the global intonation contour appear relatively constant in the frequency range across varying utterance length. This paper is a first exploration into Danish...... question intonation in non-scripted speech....

  2. Routing Questions to the Right Users in Online Communities

    DEFF Research Database (Denmark)

    Zhou, Yanhong; Cong, Gao; Cui, Bin;

    2009-01-01

    address the problem of "pushing" the right questions to the right persons, the objective being to obtain quick, high-quality answers, thus improving user satisfaction. We propose a framework for the efficient and effective routing of a given question to the top-k potential experts (users) in a forum......, by utilizing both the content and structures of the forum system. First, we compute the expertise of users according to the content of the forum system--this is to estimate the probability of a user being an expert for a given question based on the previous question answering of the user. Specifically, we...

  3. A Comparative Analysis of Elementary Mathematics Teachers’ Examination Questions And SBS Mathematics Questions According To Bloom’s Taxonomy

    OpenAIRE

    Güler, Gürsel; ÖZDEMİR, Ercan; DİKİCİ, Ramazan

    2012-01-01

    This study has been planned for the purpose of comparative analysis of examination questions of elementary mathematics teachers and mathematics questions of Placement Examination (SBS) for 6th, 7th and 8th grades in 2010 in terms of Bloom’s Taxonomy. Document analysis method was used in this study. Accordingly, 715 examination questions mathematics teachers working in 12 different primary schools asked in 2009-2010 academic year and 54 mathematics questions for 6th, 7th and 8th grades in SBS ...

  4. Profiling Students' Multiple Source Use by Question Type

    Science.gov (United States)

    List, Alexandra; Grossnickle, Emily M.; Alexander, Patricia A.

    2016-01-01

    The present study examined undergraduate students' multiple source use in response to two different types of academic questions, one discrete and one open-ended. Participants (N = 240) responded to two questions using a library of eight digital sources, varying in source type (e.g., newspaper article) and reliability (e.g., authors' credentials).…

  5. New Responses to Enduring Questions in Religious and Theological Education

    Science.gov (United States)

    Siejk, Cate

    2011-01-01

    This article offers a response to two provocative questions about the relationship of theology to religious education posed by Norma Thompson in her Presidential address given at the annual meeting of APRRE in 1978. I offer contemporary answers to these questions from the perspective of a theological educator. First, I show how feminist theory and…

  6. QTIPs: Questionable theoretical and interpretive practices in social psychology.

    Science.gov (United States)

    Brandt, Mark J; Proulx, Travis

    2015-01-01

    One possible consequence of ideological homogeneity is the misinterpretation of data collected with otherwise solid methods. To help identify these issues outside of politically relevant research, we name and give broad descriptions to three questionable interpretive practices described by Duarte et al. and introduce three additional questionable theoretical practices that also reduce the theoretical power and paradigmatic scope of psychology.

  7. Outstanding Questions about Mergers in Clusters of Galaxies

    CERN Document Server

    Sarazin, C L

    2004-01-01

    At the request of the organizers of the Santa Fe meeting on X-Ray and Radio Connections, I list some important questions and lines of inquiry for the future study of the X-ray and radio connections in mergers in clusters of galaxies, These questions are based on the talks, posters, and discussions at this meeting,

  8. Promoting Vicarious Learning of Physics Using Deep Questions with Explanations

    Science.gov (United States)

    Craig, Scotty D.; Gholson, Barry; Brittingham, Joshua K.; Williams, Joah L.; Shubeck, Keith T.

    2012-01-01

    Two experiments explored the role of vicarious "self" explanations in facilitating student learning gains during computer-presented instruction. In Exp. 1, college students with low or high knowledge on Newton's laws were tested in four conditions: (a) monologue (M), (b) questions (Q), (c) explanation (E), and (d) question + explanation (Q + E).…

  9. Intercultural Ethics: Questions of Methods in Language and Intercultural Communication

    Science.gov (United States)

    Phipps, Alison

    2013-01-01

    This paper explores how questions of ethics and questions of method are intertwined and unavoidable in any serious study of language and intercultural communication. It argues that the focus on difference and solution orientations to intercultural conflict has been a fundamental driver for theory, data collection and methods in the field. These…

  10. Questioning and Feedback in Athletic Training Clinical Education

    Science.gov (United States)

    Barnum, Mary G.; Guyer, M. Susan; Levy, Linda S.; Willeford, K. Sean; Sexton, Patrick; Gardner, Greg; Fincher, A. Louise

    2009-01-01

    The purpose of this article is to provide clinical instructors with information and ideas on how to utilize questioning and feedback during clinical experiences. Definitions, purpose, and examples of different questioning skills are provided. Corrective and directive feedback methods are defined with purposes and examples provided of each.…

  11. The Evolution of Quality Teaching and Four Questions for Change

    Science.gov (United States)

    Gabriel, Rachael

    2016-01-01

    Today we look to determine teaching quality through a combination of observation, surveys, and test scores. These measures fail to answer the most important question about quality teaching: How is it accomplished? How has this teacher used questioning today, and what drove their decision to do so? How has this teacher structured independent…

  12. Power Dynamics and Questioning in Elementary Science Classrooms

    Science.gov (United States)

    Reinsvold, Lori A.; Cochran, Kathryn F.

    2012-01-01

    We describe the dynamic discourse interactions between a teacher and her students in a third-grade science classroom. We focused on how the teacher and students initiate, prompt, respond, and provide feedback; use questioning and power strategies; and how questions are associated with power dynamics. We relate the consequences of teacher use of…

  13. 10 CFR 830.203 - Unreviewed safety question process.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Unreviewed safety question process. 830.203 Section 830... Unreviewed safety question process. (a) The contractor responsible for a hazard category 1, 2, or 3 DOE... a procedure for its USQ process on a schedule that allows DOE approval in a safety evaluation...

  14. Enhancing Science Kits with the Driving Question Board

    Science.gov (United States)

    Nordine, Jeff; Torres, Ruben

    2013-01-01

    This article describes the driving question board (DQB), a visual organizer that supports inquiry-based instruction through the use of guiding questions. The DQB is a teaching aid designed to increase student engagement alongside science kits. Information is provided on its application to a lesson on buoyancy, highlighting how it improved…

  15. Self-Generated Questions and Reading Recall: Does Training Help?

    Science.gov (United States)

    MacDonald, John D.

    1986-01-01

    Trained junior high school students were compared with untrained students on comprehension and recall after both were told to construct questions while reading text passages. Results indicate that training improved the question quality only for those students who had above average pretest free recall scores. (Author/LMO)

  16. Indian Child Welfare Act of 1978: Questions and Answers.

    Science.gov (United States)

    Administration for Native Americans (DHEW/OHDS), Washington, DC.

    The question and answer booklet highlights the provisions of the Indian Child Welfare Act of 1978 which was designed to protect the best interests of Indian children and to promote the stability and security of Indian tribes and families. The booklet attempts to answer 28 important questions concerning title I of the Act. Examples of questions…

  17. Improving passage retrieval in question answering using NLP

    NARCIS (Netherlands)

    Tiedemann, J; Bento, C; Cardoso, A; Dias, G

    2005-01-01

    This paper describes an approach for the integration of linguistic information in passage retrieval in an open-source question answering system for Dutch. Annotation produced by the wide-coverage dependency parser Alpino is stored in multiple index layers to be matched with natural language question

  18. Reclaiming Kindergarten: Part II--Questions about Policy

    Science.gov (United States)

    Gullo, Dominic F.; Hughes, Kim

    2011-01-01

    Part II of "Reclaiming Kindergarten" continues the discussion related to responding to the crisis in today's kindergarten. In Part II, two policy questions are posed, the answers to which seek to respond to this continuing crisis. The questions center on issues related to engaging families in kindergarten and the need to consider a new early…

  19. Copernican Politics: It's Time to Ask Heretical Questions.

    Science.gov (United States)

    Lamm, Richard D.

    1983-01-01

    The governor of Colorado believes we cannot find solutions to today's problems because we are not asking the right questions. Questions dealing with the problems of resource management, energy, the elderly, economic development, immigration policy, medical policy, and political change are raised. (IS)

  20. Teenagers' Web Questions Compared with a Sexuality Curriculum: An Exploration

    Science.gov (United States)

    Goldman, Juliette D. G.; McCutchen, Lisa E.

    2012-01-01

    Background: Teenagers need information about their changing bodies. Many young people do not receive adequate or accurate puberty/sexuality education from their parents or school, so many teenagers are going online to have their sexuality questions answered. Purpose: This research examines teenagers' web questions on sexuality, and an example of…

  1. Thinking Levels of Questions in Christian Reading Textbooks

    Science.gov (United States)

    Lee, Heather A.

    2015-01-01

    If Christian schools desire students to achieve higher-level thinking, then the textbooks that teachers use should reflect such thinking. Using Risner's (1987) methodology, raters classified questions from two Christian publishers' fifth grade reading textbooks based on the revised Bloom's taxonomy (Anderson et al., 2001). The questions in the A…

  2. Assessing the quality of a student-generated question repository

    Science.gov (United States)

    Bates, Simon P.; Galloway, Ross K.; Riise, Jonathan; Homer, Danny

    2014-12-01

    We present results from a study that categorizes and assesses the quality of questions and explanations authored by students in question repositories produced as part of the summative assessment in introductory physics courses over two academic sessions. Mapping question quality onto the levels in the cognitive domain of Bloom's taxonomy, we find that students produce questions of high quality. More than three-quarters of questions fall into categories beyond simple recall, in contrast to similar studies of student-authored content in different subject domains. Similarly, the quality of student-authored explanations for questions was also high, with approximately 60% of all explanations classified as being of high or outstanding quality. Overall, 75% of questions met combined quality criteria, which we hypothesize is due in part to the in-class scaffolding activities that we provided for students ahead of requiring them to author questions. This work presents the first systematic investigation into the quality of student produced assessment material in an introductory physics context, and thus complements and extends related studies in other disciplines.

  3. Sleep board review question: nocturnal hypoxemia in COPD

    Directory of Open Access Journals (Sweden)

    Poongkunran C

    2013-01-01

    Full Text Available No abstract available. Article truncated at end of question. Question: Which of the following is the strongest predictor of nocturnal hypoxemia in patients with chronic obstructive pulmonary disease (COPD?1.Forced expiratory volume in 1 second (FEV12.Age3.Daytime Oxygen Saturation4.Radiological severity of COPD…

  4. The pragmatic interpretation of intonation in Greek wh-questions

    NARCIS (Netherlands)

    Arvaniti, A.; Baltazani, M.; Gryllia, S.

    2016-01-01

    We experimentally investigated the pragmatics of two melodies commonly used with Greek wh-questions, L*H L-!H%, described as the default, and LH* L-L% considered less frequent and polite. We tested two hypotheses: (a) the !H%-ending melody is associated with information seeking questions, while the

  5. Marking sense of students' answers to multiple-choice questions

    Science.gov (United States)

    Dufresne, Robert J.; Leonard, William J.; Gerace, William J.

    2002-03-01

    A detailed example is used to illustrate the difficulties making sense of students' answers to multiple-choice questions. We explore how correct answers can be false indicators of student knowledge and understanding. We caution against excessive reliance on multiple-choice questions for instructional decisions.

  6. Some Big Questions about Design in Educational Technology

    Science.gov (United States)

    Gibbons, Andrew S.

    2016-01-01

    This article asks five questions that lead us to the foundations of design practice in educational technology. Design processes structure time, space, place, activity, role, goal, and resource. For educational technology to advance in its understanding of design practice, it must question whether we have clear conceptions of how abstract…

  7. Three Naive Questions: Addressed to the Modern Educational Optimism

    Science.gov (United States)

    Krstic, Predrag

    2016-01-01

    This paper aims to question anew the popular and supposedly self-evident affirmation of education, in its modern incarnation as in its historical notion. The "naive" questions suggest that we have recently taken for granted that education ought to be for the masses, that it ought to be upbringing, and that it is better than ignorance.…

  8. The Art of Questions: Inquiry, the CCSS, and School Librarians

    Science.gov (United States)

    Wadham, Rachel

    2013-01-01

    This article examines the association among inquiry, the Common Core State Standards (CCSS) and school librarians. It explains the significance of asking questions, and describes the characteristics of the questions that are central to inquiry learning. The role of school librarians in inquiry learning and the implementation of CCSS is also…

  9. Questions about Brain Development = Preguntas sobre el desarrollo del cerebro.

    Science.gov (United States)

    Southeastern Regional Vision for Education (SERVE), Tallahassee, FL.

    Noting that new research shows that a baby's earliest years shape how he or she grows later in life, this brochure, in English- and Spanish-language versions, provides brief answers to some important questions parents may have about their baby's brain. The questions answered are: (1) "Why is brain development a popular subject lately?; (2) "What…

  10. Multiple choice questions in electronics and electrical engineering

    CERN Document Server

    DAVIES, T J

    2013-01-01

    A unique compendium of over 2000 multiple choice questions for students of electronics and electrical engineering. This book is designed for the following City and Guilds courses: 2010, 2240, 2320, 2360. It can also be used as a resource for practice questions for any vocational course.

  11. Conceptual Question Response Times in Peer Instruction Classrooms

    Science.gov (United States)

    Miller, Kelly; Lasry, Nathaniel; Lukoff, Brian; Schell, Julie; Mazur, Eric

    2014-01-01

    Classroom response systems are widely used in interactive teaching environments as a way to engage students by asking them questions. Previous research on the time taken by students to respond to conceptual questions has yielded insights on how students think and change conceptions. We measure the amount of time students take to respond to…

  12. Teacher Questioning Behavior during Classroom Discussions of Short Stories.

    Science.gov (United States)

    McGreal, Shirley Springer

    The questions asked by nine secondary school English teachers while teaching three short stories were recorded and analyzed using a modified version of the Purves and Rippere (1968) system. Response preferences were also gathered from each teacher and from each student, using special question-preference questionnaires. The major finding of the…

  13. Questions related to Bitcoin and other Informational Money

    NARCIS (Netherlands)

    J.A. Bergstra; K. de Leeuw

    2013-01-01

    A collection of questions about Bitcoin and its hypothetical relatives Bitguilder and Bitpenny is formulated. These questions concern technical issues about protocols, security issues, issues about the formalizations of informational monies in various contexts, and issues about forms of use and misu

  14. 101 questions about energy; 101 questions sur l'energie

    Energy Technology Data Exchange (ETDEWEB)

    Furfari, S. [Commission Europeenne, Bruxelles (Belgium)

    2009-07-01

    Today, energy in the center of the world events. People get swamped with information about energy, environment, energy saving or renewable energy sources. However, the solutions proposed are still in the centre of debates and no consensus exists which allows to define a clear policy: nuclear energy or wind power? Solar energy or biomass fuels? And what about the meaning of the expression 'clean coal'? And why oil prices go up and down while it is said that the resource is close to exhaustion? Mass media are trying to tell us that 'urgency is here', mainly because of the climatic threat of greenhouse gases and because of a world economy totally dependent of politically unstable areas, like Middle East, Africa or Caucasus, but with huge oil and gas resources. And what about Europe, and what about all this gas in Russia? It is hard for a non-specialist to find his way in this complex domain. This is the aim of this book which has opted for the non-politically correct attitude to answer 101 key-questions about the energy topic: Europe's security of supply, energy geopolitics, oil future, energy crises, sustainable development etc. (J.S.)

  15. Importance of questionnaire context for a physical activity question

    DEFF Research Database (Denmark)

    Jørgensen, M. E.; Sørensen, Mette Rosenlund; Ekholm, O.;

    2013-01-01

    Adequate information about physical activity habits is essential for surveillance, implementing, and evaluating public health initiatives in this area. Previous studies have shown that question order and differences in wording result in systematic differences in people's responses to questionnaires...... Register. A new question about physical activity was included with minor differences in formulations in samples 1–3. Furthermore, the question in sample 2 was included in sample 4 but was placed in the end of the questionnaire. The mean time spent on moderate physical activity varied between the four...... samples from 57 to 100 min/day. Question order was associated with the reported number of minutes spent on moderate-intensity physical activity and with prevalence of meeting the recommendation, whereas physical inactivity was associated with the differences in formulation of the question. Questionnaire...

  16. Lexical Disambiguation in Natural Language Questions-NLQs

    Directory of Open Access Journals (Sweden)

    Omar Al-Harbi

    2011-07-01

    Full Text Available Question processing is a fundamental step in a question answering (QA application, and its quality impacts the performance of QA application. The major challenging issue in processing question is how to extract semantic of natural language questions (NLQs. A human language is ambiguous. Ambiguity may occur at two levels; lexical and syntactic. In this paper, we propose a new approach for resolving lexical ambiguity problem by integrating context knowledge and concepts knowledge of a domain, into shallow natural language processing (SNLP techniques. Concepts knowledge is modeled using ontology, while context knowledge is obtained from WordNet, and it is determined based on neighborhood words in a question. The approach will be applied to a university QA system.

  17. [Building questions in forensic medicine and their logical basis].

    Science.gov (United States)

    Kovalev, A V; Shmarov, L A; Ten'kov, A A

    2015-01-01

    The authors characterize in brief the requirements to the correct formulation of the questions posed to forensic medical experts with special reference to the mistakes made in building the questions and the ways to avoid them. This article actually continues the series of publications of the authors concerned with the major logical errors encountered in expert conclusions. Further publications will be dedicated to the results of the in-depth analysis of the logical errors contained in the questions posed to forensic medical experts and encountered in the expert conclusions.

  18. Ontologies and adaptivity in dialogue for question answering

    CERN Document Server

    Sonntag, D

    2010-01-01

    Question answering (QA) has become one of the fastest growing topics in computational linguistics and information access. To advance research in the area of dialogue-based question answering, we propose a combination of methods from different scientific fields (i.e., Information Retrieval, Dialogue Systems, Semantic Web, and Machine Learning). This book sheds light on adaptable dialogue-based question answering. We demonstrate the technical and computational feasibility of the proposed ideas, the introspective methods in particular, by beginning with an extensive introduction to the dialogical

  19. Question of the Day Where Truth is the Dare

    CERN Document Server

    Katkowsky, Al

    2011-01-01

    Perfect for spending time with friends, family or even co-workers, Question of the Day is designed to help people explore a variety of topics that challenge them to think, be brutally honest, and form perhaps previously unstated opinions. Using these questions is fun, enlightening, surprising and revealing-ideal as an ice breaker among willing acquaintances or as a source of deeper conversation among old friends. It's fun, but also challenging and the subtitle is meant to reflect that. Questions are ranked on a scale from "light" to "heavy" indicating the introspection, honesty, and even deep

  20. How do 5-year-olds understand questions?

    DEFF Research Database (Denmark)

    Sauerland, Uli; Grohmann, Kleanthes; Teresa Guasti, Maria;

    2016-01-01

    developing children across 19 European countries, 18 different languages, and 7 language (sub-)families. The study investigated the effects of two factors on question formation: (a) whether the question contains a simple interrogative word like ‘who’ or a complex one like ‘which princess’, and (b) whether...... the question word was related to the sentential subject or object position of the verb. The findings show that there is considerable variation among languages, but the two factors mentioned consistently affect children’s performance. The cross-linguistic variation shows that three linguistic factors facilitate...

  1. Conceptual Links between Two Mad Cow Crises: The Absence of Paradigmatic Change and Policymaking Implications

    OpenAIRE

    Labrecque, Joanne; Charlebois, Sylvain

    2006-01-01

    On March 20, 1996, a day known as Black Wednesday to the British beef industry, the British Secretary of State of Health announced that a possible link existed between BSE and the Creutzfeldt-Jakob disease (vCJD), the human variant of mad cow. Seven years later, a somewhat comparable fate struck the Canadian beef industry. In May 2003, the discovery of the first native North American case of BSE in Canada deflated the prospects of the industry across the country, consequently creating environ...

  2. Questioning As a Pedagogical Tool for Eliciting Student Generated Questions During the Teaching of Acid-base Equilibria

    Directory of Open Access Journals (Sweden)

    Ayoade Ejiwale Okanlawon

    2012-04-01

    Full Text Available Traditionally, teachers simply taught problem-solving by explaining the worked-out examples taken from textbooks and students were expected to listen quietly, copy the solution to the problem, and then work independently at their desks. But a large body of research notes that guiding students to develop a solution pathway with questioning is more effective than simply explaining the sequence of steps to solve the problem. Students involved in question- and-answer sessions are more attentive than those who listen passively to teacher explanations and they are more likely to generate questions. The questions students ask during a lesson perform a number of important functions, including providing the teacher with valuable information about students’ understanding and misunderstanding, fostering self-regulation, inviting classroom discussions and aiding comprehension of contents presented. The skill of posing questions during classroom instruction is often under-valued and under taught in today’s classrooms. To encourage students to ask quality and thought provoking questions related to the contents taught, explicit instruction is required. This paper, therefore, qualitatively reports factors that foster student generated questions during the problem-solving instruction involving acid-base titration problem.

  3. A Tattoo for You? Seven Key Questions to Consider

    Science.gov (United States)

    ... For Consumers Home For Consumers Consumer Updates A Tattoo for You? Seven Key Questions to Consider Share ... to top 3. What about do-it-yourself tattoo inks and kits? Inks and kits sold online ...

  4. Questions and Answers about Ebola, Pets, and Other Animals

    Science.gov (United States)

    ... Questions and Answers about Ebola, Pets, and Other Animals Language: English Español Français Recommend on Facebook Tweet Share Compartir How are animals involved in Ebola outbreaks? Because the natural reservoir ...

  5. A Question Answering service for information retrieval in Cooper

    NARCIS (Netherlands)

    Giesbers, Bas; Taddeo, Antonio; Van der Vegt, Wim; Van Bruggen, Jan; Koper, Rob

    2007-01-01

    Giesbers, B., Taddeo, A., van der Vegt, W., van Bruggen, J., Koper, R. (2007). A Question Answering service for information retrieval in Cooper. Paper presented at the Cooper workshop, September 18, Crete, Greece.

  6. Frequently Asked Questions about Measles in the U.S.

    Science.gov (United States)

    ... Pan American Health Organization Frequently Asked Questions about Measles in the U.S. Recommend on Facebook Tweet Share ... I’ve been exposed to someone who has measles. What should I do? A: Immediately call your ...

  7. Zika Virus Infection and Zika Fever: Frequently Asked Questions

    Science.gov (United States)

    ... Frequently asked questions Updated: 25 March 2016 ABOUT ZIKA What is Zika virus infection? Zika virus infection is caused by ... possible to characterize the disease better. How is Zika virus transmitted? Zika virus is transmitted to people ...

  8. Professional activity of officers on questions of physical training management

    Directory of Open Access Journals (Sweden)

    Olkhovyi O.M.

    2012-11-01

    Full Text Available Certain requirement to the typical tasks of professional activity of officers on questions of guidance, organization and leadthrough of physical training in Military Powers of Ukraine is determined. Constituents, components and structure of model of professional activity of officers on questions of physical preparation management are analysed. The basic factors of guidance and way of their realization are exposed. It is selected that the process of managing of physical training in accordance with principles and management methods and taken to making a decision and their realization is carried out. The technological sequence of creation of components of the system of preparation of officers to implementation of official questions is certain. The model of professional activity of officers on questions of management is created. The selected kinds by which officers carry out the functional duties are guidance.

  9. Opportunities and questions for the fundamental biological sciences in space

    Science.gov (United States)

    Sharp, Joseph C.; Vernikos, Joan

    1993-01-01

    With the advent of sophisticated space facilities we discuss the overall nature of some biological questions that can be addressed. We point out the need for broad participation by the biological community, the necessary facilities, and some unique requirements.

  10. French people opinion about energy question in spring 1992

    International Nuclear Information System (INIS)

    This paper presents a statistical study of french people opinion about energy questions: the main subjects studied are the competitiveness of energy sources and the forecasts about the evolution of energy prices. 4 tabs

  11. Colorectal (Colon) Cancer: Questions to Ask Your Doctor

    Science.gov (United States)

    ... Stay Informed Cancer Home Questions to Ask Your Doctor About Colorectal Cancer Language: English Español (Spanish) Recommend ... helps pay for colorectal cancer screening. Ask Your Doctor Do I need to get a screening test ...

  12. Questions and answers based on revised 10 CFR Part 20

    International Nuclear Information System (INIS)

    NUREG/CR-6204 is a collection of questions and answers that were originally issued in seven sets and which pertain to revised 10 CFR Part 20. The questions came from both outside and within the NRC. The answers were compiled and provided by NRC staff within the offices of Nuclear Reactor Regulation, Nuclear Material Safety and Safeguards, Nuclear Regulatory Research, the Office of State Programs, and the five regional offices. Although all of the questions and answers have been reviewed by attorneys in the NRC Office of the General Counsel, they do not constitute official legal interpretations relevant to revised 10 CFR Part 20. The questions and answers do, however, reflect NRC staff decisions and technical options on aspects of the revised 10 CFR Part 20 regulatory requirements. This NUREG is being made available to encourage communication among the public, industry, and NRC staff concerning the major revisions of the NRC's standards for protection against radiation

  13. Study Questions Use of Antidepressants for Children, Teens

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_159262.html Study Questions Use of Antidepressants for Children, Teens They ... interpersonal therapy -- as the first-line treatment," said study author Dr. Andrea Cipriani. He is an associate ...

  14. Interviewers' challenging questions in British broadcast debate interviews

    DEFF Research Database (Denmark)

    Emmertsen, Sofie

    2007-01-01

    that interviewers’ initial challenging questions polarise interviewees’ positions and that confrontation between interviewees is an expected and normative part of the interaction. Focusing on the grammatical, lexical and sequential design of interviewers’ initial challenges, the analysis will attempt to show...

  15. Further investigations on a question of Zhang and Lü

    Directory of Open Access Journals (Sweden)

    Abhijit Banerjee

    2015-09-01

    Full Text Available In the paper taking the question of Zhang and Lü [15] into background, wepresent one theorem which will improve and extend results of Banerjee-Majumdar [2] and arecent result of Li-Huang [9].

  16. Purchasing Educational Materials--Questions from the Field.

    Science.gov (United States)

    Neugebauer, Roger

    2000-01-01

    Lists 16 questions to address when pondering the purchase of educational materials. Addressed are issues of educational potential, health and safety to children, age flexibility, potential for skill development, structural integrity, and adequate customer service. (SD)

  17. The recent evolution of the question "What is life"?

    Science.gov (United States)

    Morange, Michel

    2012-01-01

    The question "What is life?" is absent from the writings of present-day biologists and scientists. However, an answer to this question, even if only partial, is needed for successful completion of projects in astrobiology and synthetic biology. The reasons for this absence are metaphysical, epistemological, and historical. No one has a full answer to this question, but there are many good reasons to keep posing it. Answers are no longer sought in the existence of strengths or mechanisms specific to life. The secret of life has been unveiled and it is nothing other than physical chemistry. What remains to be understood is the way the characteristics of organisms have emerged and been combined within one unique "object." The answer to the question "What is life?" is now looked for in the scenario that generated life.

  18. Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease: how safe is eating beef?

    Science.gov (United States)

    Roma, Andres A; Prayson, Richard A

    2005-03-01

    Cases of bovine spongiform encephalopathy (BSE, mad cow disease) have been found in North American cattle. Its human counterpart, called variant Creutzfeldt-Jakob disease (variant CJD), is rare but seems to be linked to eating diseased beef. Many questions remain about these diseases, such as why young people seem at greater risk of variant CJD. Also, are some people more genetically at risk for acquiring variant CJD than others? PMID:15825799

  19. Question Answering on Freebase via Relation Extraction and Textual Evidence

    OpenAIRE

    Xu, Kun; Reddy, Siva; Feng, Yansong; Huang, Songfang; Zhao, Dongyan

    2016-01-01

    Existing knowledge-based question answering systems often rely on small annotated training data. While shallow methods like relation extraction are robust to data scarcity, they are less expressive than the deep meaning representation methods like semantic parsing, thereby failing at answering questions involving multiple constraints. Here we alleviate this problem by empowering a relation extraction method with additional evidence from Wikipedia. We first present a neural network based relat...

  20. Questions Concerning Matrix Algebras and Invariance of Spectrum

    Indian Academy of Sciences (India)

    Bruce A Barnes

    2003-02-01

    Let and be unital Banach algebras with a subalgebra of . Denote the algebra of all × matrices with entries from by $M_n(A)$. In this paper we prove some results concerning the open question: If is inverse closed in , then is $M_n(A)$ inverse closed in $M_n(B)$? We also study related questions in the setting where is a symmetric Banach ∗-algebra.

  1. Automatic Question Generation Using Software Agents for Technical Institutions

    OpenAIRE

    Shivank Pandey; K.C. Rajeswari

    2013-01-01

    In the attempt of producing quality graduates, a major factor that needs a considerable amount of attention is the institutions evaluation system. Now, in order to produce quality result their examination system must be very effective, questions must be able to assess students in every domain. Preparation of question paper with high standard that really kindles the student’s thinking ability is very challengeable task that need to be performed by the academicians. There arises a need for auto...

  2. Power dynamics and questioning in elementary science lessons

    Science.gov (United States)

    Reinsvold, Lori Ann

    Discourse interactions between a teacher and students in an inquiry-based fourth-grade science classroom were analyzed to investigate how power dynamics and questioning strategies within elementary science lessons help support students in building their science understanding. Five inquiry-based classroom sessions were observed; verbal interactions were audio- and video-recorded. Research data consisted of observation transcripts, teacher interviews, student work, and instructional materials. Analyses were conducted on the frequencies of utterances, participation roles, power categories, and questioning categories. Results revealed that when students used more frequent power, (a) no significant differences were noted between frequencies of teacher and student talk, (b) the teacher posed more questions than did the students, and (c) students explained what they knew and asked questions to clarify their understanding. When the teacher used more frequent power, she asked questions to provide students opportunities to negotiate investigative processes and explain what they knew and how they knew it. Evidence of student understanding of the science concepts was found in how students used subject matter to discuss what they knew and how they knew it. Pre-service and in-service teachers should be encouraged to consider how their use of power and questioning strategies can engage students to reflect on how they build understanding of science concepts. Teachers can use Professional Learning Communities to reflect on how their practice engages students. Future research should be employed to observe classrooms across an entire school year to determine how power and questioning dynamics flow among students and teachers and change over time. Research can also be used to understand the influence of gender and culture on power and questioning dynamics in classroom settings.

  3. The agrarian question and violence in Colombia: conflict and development

    OpenAIRE

    Thomson, Frances

    2011-01-01

    This article examines connections between Colombia’s internal armed conflict and agrarian questions. It pays attention to the country’s specific historical trajectory of agrarian change, the violent expression of social tensions that this elicited, and the particular ways in which these dynamics were influenced by a changing global context.This analysis of the intimate ties between violent conflict and agrarian questions in Colombia, both in terms of their historical development and their con...

  4. How to make allocation decisions: a theory and test questions.

    Science.gov (United States)

    2005-01-01

    Hospital administrators are regularly faced with having to cut patient services. Such decisions are essentially questions of distributive justice, and administrators may welcome some guidance. We begin with a key idea from the most influential theory of justice of our times, that of John Rawls, and generate from it a series of test questions against which the ethical dimensions of allocation decisions can be judged.

  5. Children's performance on ground rules questions: implications for forensic interviewing.

    Science.gov (United States)

    Dickinson, Jason J; Brubacher, Sonja P; Poole, Debra A

    2015-02-01

    Ground rules, also called interview instructions, are included in investigative interviews with children around the world. These rules aim to manage the expectations of children who are typically unaccustomed to being questioned by adults who are naïve to the children's experiences. Although analog research has examined the efficacy of ground rules instruction, a systematic analysis of children's ability to respond appropriately to each of the rules has not been reported. In the current study, we scored the accuracy of children's (N = 501, 4 to 12 years) responses to 5 ground rules practice questions (e.g., "What is my dog's name?") and 2 questions that asked whether they would follow the rules, and then assigned inaccurate responses to 1 of several error categories. Few children answered every question correctly, but their performance on individual questions was encouraging. As expected, there were marked differences in children's understanding across ground rules questions (especially among the younger children), with "Don't guess" and "Tell the truth" rules being the easiest to comprehend. Together with evidence that ground rules instruction takes little time to deliver (typically 2 to 4 min) and is associated with improved accuracy in previous research, these findings support the use of ground rules in investigative interviews of children 4 years and older. PMID:25642973

  6. Interviewer Effects on a Network-Size Filter Question

    Directory of Open Access Journals (Sweden)

    Josten Michael

    2016-06-01

    Full Text Available There is evidence that survey interviewers may be tempted to manipulate answers to filter questions in a way that minimizes the number of follow-up questions. This becomes relevant when ego-centered network data are collected. The reported network size has a huge impact on interview duration if multiple questions on each alter are triggered. We analyze interviewer effects on a network-size question in the mixed-mode survey “Panel Study ‘Labour Market and Social Security’” (PASS, where interviewers could skip up to 15 follow-up questions by generating small networks. Applying multilevel models, we find almost no interviewer effects in CATI mode, where interviewers are paid by the hour and frequently supervised. In CAPI, however, where interviewers are paid by case and no close supervision is possible, we find strong interviewer effects on network size. As the area-specific network size is known from telephone mode, where allocation to interviewers is random, interviewer and area effects can be separated. Furthermore, a difference-in-difference analysis reveals the negative effect of introducing the follow-up questions in Wave 3 on CAPI network size. Attempting to explain interviewer effects we neither find significant main effects of experience within a wave, nor significantly different slopes between interviewers.

  7. CT and MRI in iatrogenic and sporadic Creutzfeldt-Jakob disease: as far as imaging perseives

    Energy Technology Data Exchange (ETDEWEB)

    Garcia Santos, J.M. [Servicio de Radiodiagnostico, HU Dr. Morales Meseguer, Murcia (Spain)]|[Section of Neuroradiology, HU Virgen de la Arrixaca, Murcia (Spain); Lopez Corbalan, J.A. [Section of Neuroradiology, HU Virgen de la Arrixaca, Murcia (Spain); Martinez-Lage, J.F. [Service of Neurosurgery, HU Virgen de la Arrixaca, Murcia (Spain); Sicilis Guillen, J. [Service of Neurology, HU Virgen de la Arrixaca, Murcia (Spain)

    1996-04-01

    Creutzfeldt-Jakob Disease (CJD), an invariably fatal dementing illness, affects patients in middle and old age (sporadic form). However, the association of CJD with certain treatments (iatrogenic form) has been described in younger patients. The clinical onset of the two forms seems to differ; in the iatrogenic form a high frequency of the ataxic CJD variant has been reported. Nowadays, a definitive diagnosis of CJD is exclusively histological. We present five cases of CJD, one sporadic and the others iatrogenic, following dura mater grafts and analyse their CT and MRI features. CT typically demonstrates brain atrophy, generally progressive, but in sporadic CJD midfield MRI also showed abnormal signal, with predominant deep grey matter involvement. The use of narrow windows with proton-density sequences may reveal subtle cortical signal abnormalities not clearly visible with conventional windows. The early demonstration of these changes, in the appropriate clinical context, may suggest CJD and this supports the use of mid- or high magnetic fields in the diagnosis of CJD and other forms of dementia. In our cases of iatrogenic CJD, low-field MRI did not reveal more than the progressive atrophy displayed by CT, and raises the question on the one hand of possible differences, based on imaging, from the sporadic form, and on the other of the lack of sensitivity of low-field magnets to signal changes in CJD. (orig.)

  8. Analysing a reading strategy based on the elaboration of questions and the pair of answers and questions

    OpenAIRE

    Wilmo Ernesto Francisco Junior

    2011-01-01

    This paper describes a reading activity developed with chemistry students. The main aim was to analyse the reflections produced after reading three articles about experimentation. This study was performed with 17 chemistry students from a federal university. The reading strategy involved writing productions. Questions and the pair of questions and answers elaborated from articles were analysed, as well as the contribution of the socialization of knowledge by means of discussions and a debate....

  9. Conducting systematic reviews of intervention questions I: Writing the review protocol, formulating the question and searching the literature.

    Science.gov (United States)

    O'Connor, A M; Anderson, K M; Goodell, C K; Sargeant, J M

    2014-06-01

    This article is the fourth of six articles addressing systematic reviews in animal agriculture and veterinary medicine. Previous articles in the series have introduced systematic reviews, discussed study designs and hierarchies of evidence, and provided details on conducting randomized controlled trials, a common design for use in systematic reviews. This article describes development of a review protocol and the first two steps in a systematic review: formulating a review question, and searching the literature for relevant research. The emphasis is on systematic reviews of questions related to interventions. The review protocol is developed prior to conducting the review and specifies the plan for the conduct of the review, identifies the roles and responsibilities of the review team and provides structured definitions related to the review question. For intervention questions, the review question should be defined by the PICO components: population, intervention, comparison and outcome(s). The literature search is designed to identify all potentially relevant original research that may address the question. Search terms related to some or all of the PICO components are entered into literature databases, and searches for unpublished literature also are conducted. All steps of the literature search are documented to provide transparent reporting of the process.

  10. Atypical Creutzfeldt-Jakob Disease Evolution after Electroconvulsive Therapy for Catatonic Depression

    Directory of Open Access Journals (Sweden)

    Iria Grande

    2011-01-01

    Full Text Available We describe a case report of an 80-year-old woman who presented with symptomatology compatible with an episode of major depression with catatonia. After psychiatric admission, electroconvulsive therapy (ECT was applied, but symptoms progressed with cognitive impairment, bradykinesia, widespread stiffness, postural tremor, and gait disturbance. After compatible magnetic resonance imaging (MRI, diffusion changes, and electroencephalogram (EEG findings the case was reoriented to Creutzfeldt-Jakob disease (CJD. The genetic study found a methionine/valine heterozygosity at codon 129 of the prion protein gene PrPSc. On followup, a significant clinical recovery turned out. For this reason, EEG and MRI were repeated and confirmed the findings. The patient subsequently demonstrated progressive clinical deterioration and died 21 months later. The diagnosis was verified postmortem by neuropathology. The vCJD subtype MV2 is indeed characterized by early and prominent psychiatric symptoms and a prolonged disease duration however no frank clinical recovery has before been reported.

  11. The variant Creutzfeldt-Jakob Disease: Risk, uncertainty or safety in the use of blood and blood derivatives?

    Science.gov (United States)

    Liras, Antonio

    2008-01-01

    It has been long since French physician Jean-Baptiste Denys carried out the first successful blood transfusion to a human being. Using bird feathers as canules, sheep blood was transfused to a young man. The patient died soon after Denys' treatment and Denys was accused of murder. In the XXI century, known as the biotechnology century, we face new challenges in Medicine. New emerging and reemerging diseases, such as Creutzfeldt-Jakob disease (CJD) or "mad cow disease" and its human variant (vCJD), challenge the biosafety aspects of a widely extended and extremely useful technique, that is, the perfusion of blood, of its derived components and of other pharmacological products obtained from plasma. To face these new challenges we need innovative prevention strategies. PMID:18573217

  12. Molyneux's Question: A Window on Crossmodal Interplay in Blindness

    Directory of Open Access Journals (Sweden)

    Valeria Occelli

    2014-04-01

    Full Text Available In 1688, the Irish scientist William Molyneux sent a letter to the philosopher John Locke in which he asked whether a man who had been born blind and whose experience of the world was based on senses other than vision, would be able to distinguish and name a globe and a cube by sight alone, once he had been enabled to see. This issue immediately raised considerable interest amongst philosophers, who, for centuries, have continued to speculate about how this issue might be resolved. More recently, the possibility of corrective surgery for people born with congenital cataracts, has offered a valuable opportunity to explore this topic experimentally. A discussion of how Molyneux’s question has been addressed over the centuries, allows us to investigate a number of intellectual challenges, involving a variety of fields, ranging from philosophy, psychology and the cognitive sciences, to neuroscience. For instance, Molyenux’s question raises the question of whether sensory experience is specific to each sensory modality, or rather supramodal, and if a transfer of knowledge across modalities can be established. Molyneux’s question is also relevant to the discussion of whether, how and to what extent a concept of space can be developed by blind people. More generally, it concerns the idea of how conceptual knowledge is acquired and processed when vision is lacking. The present paper aims to provide an overview of all the issues raised by Molyenux’s question.

  13. On the Question of Validity of the Anthropic Principles

    International Nuclear Information System (INIS)

    During the last centuries of human history, many questions was repeated in connection with the great problems of the existence and origin of human beings, and also of the Universe. The old questions of common sense and philosophy have not been solved in spite of the indisputable results of modern natural sciences. Recently the so-called anthropic principles show that these questions are still present. We investigated some important results of the modern cosmology and their consequences with respect to the corresponding questions of philosophy and logic. After a short conceptual introduction there are two baselines. It is shown st how Goedel's theorem affects the foundation of anthropic principles. Our train of thought shows that Goedel's incompleteness theorem may deny some efforts claiming that anthropic principles can be ruled out. After this in the Appendix we touch the branch of questions that are connected with the philosophical aspects of anthropic principles and the multiple-world hypothesis. Here we investigated those formulae of quantum theory, which are supposed to be the ground for the theory of many worlds-hypothesis. Although our method is based partly on philosophy and logic, it is mainly grounded in the results and methods of natural sciences. So we need both physics and philosophy to go in our way. (author)

  14. Multiple choice questions: their value as an assessment tool.

    Science.gov (United States)

    Moss, E

    2001-12-01

    Multiple choice questions are a well-established, reliable method of assessing knowledge and are used widely in postgraduate examinations in anaesthesiology. Like other methods of assessment they have their strengths and weaknesses. With the drive for revalidation and changes in undergraduate medical education much work has been done on devising valid, reliable and feasible methods of assessment of clinical practice including the need for the use of several different methods. Different multiple choice question formats have been devised and the importance of well-written multiple choice questions with clear assessment objectives recognized. There is controversy about the use of number-right as opposed to negative marking but, provided that the candidates know which marking system is being used, either method is satisfactory. The pass standard should be determined using criterion-based rather than norm-based referencing. Multiple choice questions could be used to validate continuing education and professional development from reading, possibly using web-based technology. For as long as there is a need to test knowledge in the assessment of doctors and medical undergraduates multiple choice questions will have a part to play, but only as one component of the assessment of clinical competence. PMID:17019162

  15. Top 10 Research Questions Related to Physical Literacy.

    Science.gov (United States)

    Longmuir, Patricia E; Tremblay, Mark S

    2016-01-01

    The term physical literacy is relatively new, and its definition, conceptual underpinning, how it is measured, how to change it, and its relationship with holistic health and wellness across the life span are a few of many foundational issues that lack consensus. At present, there are more questions than answers. The purpose of this article is to highlight 10 important research questions related to physical literacy with the hope of fueling future research activity and debate. Input was sought from international experts and practitioners on priorities and research gaps related to physical literacy. This list was supplemented by personal experience and research priorities identified in published manuscripts. From these various sources, the top 10 research questions related to physical literacy were compiled. Research related to physical literacy is in its infancy, and many important, even fundamental research questions and priorities remain unanswered. Research needs are summarized within 4 themes: monitoring physical literacy, understanding the physical literacy journey, enhancing physical literacy, and the benefits of physical literacy. Specific research questions relate to identifying measurable aspects of physical literacy and how they change across cultures and throughout the life span, as well as understanding the individual and environmental factors that describe the physical literacy journey and are effective targets for interventions. Physical literacy is increasingly recognized as the foundation for a healthy active lifestyle; however, robust research demonstrating its constitution, its relationship with health-related outcomes, and intervention strategies for its improvement remains to be completed. PMID:26889582

  16. Intention-to-treat. What is the question?

    Directory of Open Access Journals (Sweden)

    Feinman Richard D

    2009-01-01

    Full Text Available Abstract It has become commonplace for Randomized Controlled Trials (RCTs to be analyzed according to Intention-to-Treat (ITT principles in which data from all subjects are used regardless of the subjects' adherence to protocol. While ITT analyses can provide useful information in some cases, they do not answer the question that motivates many RCTs, namely, whether the treatments differ in efficacy. ITT tends to reduce information by combining two questions, whether the intervention is effective and whether, as implemented, it has good compliance. Because these questions may be separate there is a risk of misuse. Two examples are presented that demonstrate this potential for abuse: a study on the effectiveness of vitamin E in reducing cardiovascular risk and comparisons of low fat and low carbohydrate diets. In the first case, a treatment that is demonstrably effective is described as without merit. In the second, ITT describes as the same, two diets that actually have different outcomes. These misuses of ITT are not atypical and are not technical problems in statistics but have real consequences for scientific principles and health recommendations. ITT analyses may answer the question of what happens when treatments are recommended but are inappropriate where separate information on adherence and performance is available. It is proposed that results of RCTs, or any experimental study, be reported, not in terms of the analyses that were performed, but rather in terms of the questions that the analyses can answer properly.

  17. Does Question Structure Affect Exam Performance in the Geosciences?

    Science.gov (United States)

    Day, E. A.; D'Arcy, M. K.; Craig, L.; Streule, M. J.; Passmore, E.; Irving, J. C. E.

    2015-12-01

    The jump to university level exams can be challenging for some students, often resulting in poor marks, which may be detrimental to their confidence and ultimately affect their overall degree class. Previous studies have found that question structure can have a strong impact on the performance of students in college level exams (see Gibson et al., 2015, for a discussion of its impact on physics undergraduates). Here, we investigate the effect of question structure on the exam results of geology and geophysics undergraduate students. Specifically, we analyse the performance of students in questions that have a 'scaffolded' framework and compare them to their performance in open-ended questions and coursework. We also investigate if observed differences in exam performance are correlated with the educational background and gender of students, amongst other factors. It is important for all students to be able to access their degree courses, no matter what their backgrounds may be. Broadening participation in the geosciences relies on removing systematic barriers to achievement. Therefore we recommend that exams are either structured with scaffolding in questions at lower levels, or students are explicitly prepared for this transition. We also recommend that longitudinal studies of exam performance are conducted within individual departments, and this work outlines one approach to analysing performance data.

  18. Means of Question-Answer Interaction for Collaborative Development Activity

    Directory of Open Access Journals (Sweden)

    Petr Sosnin

    2009-01-01

    Full Text Available The key problem of successful developing of the software intensive system (SIS is adequate conceptual interactions of stakeholders at the early stages of designing. Nowadays the success of development is extremely low. It can be increased with using artificial intelligence (AI means including models of reasoning supported by the human-computer interaction in collaborative development activity. In this paper, a number of question-answer means for modeling reasoning are suggested. Such kind of means is defined and implemented in order to get effects of integrating the collective reasoning for their positive influence on the intellectual activity of designers. Question-answer means are arranged as a specialized processor opening the possibility to question-answer programming of the tasks on the conceptual stage of designing. Suggested and investigated means can be used for solving any complicated task.

  19. Towards the full information chain theory: question difficulty

    CERN Document Server

    Perevalov, Eugene

    2012-01-01

    A general problem of optimal information acquisition for its use in decision making problems is considered. This motivates the need for developing quantitative measures of information sources' capabilities for supplying accurate information depending on the particular content of the latter. In this article, the notion of a real valued difficulty functional for questions identified with partitions of problem parameter space is introduced and the overall form of this functional is derived that satisfies a particular system of reasonable postulates. It is found that, in an isotropic case, the resulting difficulty functional depends on a single scalar function on the parameter space that can be interpreted -- using parallels with classical thermodynamics -- as a temperature-like quantity, with the question difficulty itself playing the role of thermal energy. Quantitative relationships between difficulty functionals of different questions are also explored.

  20. Sociodemographic differences in dietary habits described by food frequency questions

    DEFF Research Database (Denmark)

    Dynesen, Anja Weirsøe; Haraldsdottír, Johanna; Holm, Lotte;

    2003-01-01

    OBJECTIVES: To investigate whether a modest number of food frequency questions are sufficient to describe sociodemographic differences in dietary habits, and to identify sociodemographic characteristics of subjects adhering to food-based dietary guidelines operationalised in a "healthy-diet index...... be a valuable supplement to traditional quantitative dietary surveys in monitoring sociodemographic changes in eating patterns. The results also underline the influence of sociodemographic status on dietary habits. SPONSORSHIP: The Danish Nutrition Council funded the study.......OBJECTIVES: To investigate whether a modest number of food frequency questions are sufficient to describe sociodemographic differences in dietary habits, and to identify sociodemographic characteristics of subjects adhering to food-based dietary guidelines operationalised in a "healthy-diet index...... household vs single household). The results also showed that gender difference in dietary habits is associated with other sociodemographic variables. CONCLUSIONS: The selected food frequency questions proved sufficient to describe sociodemographic differences in dietary habits, and this method may...

  1. Relativity and the question of discretization in astronomy

    CERN Document Server

    Edelen, Dominic G B

    1970-01-01

    Theoretical researches in general relativity and observational data from galactic astronomy combine in this volume in contributions to one of the oldest questions of natural philosophy: Is the structure of the physical world more adequately described by a continuous or a discrete mode of representation? Since the days of the Pythagoreans, this question has surfaced from time to time in various guises in science as well as in philosophy. One of the most bitterly contested and illuminating controversies between the continuous and the discrete viewpoints is to be found in the wave versus corpuscular description of optical phenom­ enae. This controversy was not resolved to the satisfaction of most of its protaganists until the development of the quantum theory. However, several obscurities that still becloud the question suggest that some deeper formulation may be necessary before more satisfactory answers can be given 1. The firm establishment of the validity of quantized structure and discrete energy distribut...

  2. On the Development of Episodic Memory: Two Basic Questions

    DEFF Research Database (Denmark)

    Dahl, Jonna Jelsbak; Sonne, Trine; Kingo, Osman Skjold;

    2013-01-01

    In this focused review we present and discuss two basic questions related to the early development of episodic memory in children: (1) “What is an episode?”, and (2) “How do preverbal children recall a specific episode of a recurring event?” First, a brief introduction to episodic memory...... is outlined. We argue in favor of employing a definition of episodic memory allowing us to investigate the development of episodic memory by purely behavioral measures. Second, research related to each of the two questions are presented and discussed, at first separately, and subsequently together. We argue...... and attempt to demonstrate, that pursuing answers to both questions is of crucial importance – both conceptually and methodologically - if we are ever to understand the early development of episodic memory. ...

  3. Development of Yes/No Arabic Question Answering System

    Directory of Open Access Journals (Sweden)

    Wafa N Bdour

    2013-01-01

    Full Text Available Developing Question Answering systems has been one of the important research issues because it requires insights from a variety of disciplines, including, Artificial Intelligence, Information Retrieval, Information Extraction, Natural Language Processing, and Psychology. In this paper we realize a formal model for a lightweight semantic–based open domain yes/no Arabic question answering system based on paragraph retrieval (with variable length. We propose a constrained semantic representation. Using an explicit unification framework based on semantic similarities and query expansion (synonyms and antonyms. This frequently improves the precision of the system. Employing the passage retrieval system achieves a better precision by retrieving more paragraphs that contain relevant answers to the question; It significantly reduces the amount of text to be processed by the system.

  4. CERCLA Site Assessment questions and answers (Qs&As)

    Energy Technology Data Exchange (ETDEWEB)

    Traceski, T.T.

    1993-11-09

    This documents contains commonly asked questions and corresponding answers (Qs&As) on the CERCLA Site Assessment process. These questions were derived from DOE element responses to a solicitation calling for the identification of (unresolved) issues associated with the conduct of CERCLA site assessments, and from inquiries received during a series of Site Assessment Workshops provided by the Environmental Protection Agency (EPA) and the Office of Environmental Guidance, RCRA/CERCLA Division (EH-231). Answers to these questions were prepared by EH-231 in cooperation with the EPA Federal Facilities Team in Office of Solid Waste and Emergency Response, Site Assessment Branch, and in coordination with the Office of Environmental Compliance, Facilities Compliance Division (EH-222).

  5. Children's identification of questions from rising terminal pitch.

    Science.gov (United States)

    Saindon, Mathieu R; Trehub, Sandra E; Schellenberg, E Glenn; VAN Lieshout, Pascal

    2016-09-01

    Young children are slow to master conventional intonation patterns in their yes/no questions, which may stem from imperfect understanding of the links between terminal pitch contours and pragmatic intentions. In Experiment 1, five- to ten-year-old children and adults were required to judge utterances as questions or statements on the basis of intonation alone. Children eight years of age or younger performed above chance levels but less accurately than adult listeners. To ascertain whether the verbal content of utterances interfered with young children's attention to the relevant acoustic cues, low-pass filtered versions of the same utterances were presented to children and adults in Experiment 2. Low-pass filtering reduced performance comparably for all age groups, perhaps because such filtering reduced the salience of critical pitch cues. Young children's difficulty in differentiating declarative questions from statements is not attributable to basic perceptual difficulties but rather to absent or unstable intonation categories. PMID:26374079

  6. Care for the elderly: the question of social goals.

    Science.gov (United States)

    Collopy, B J

    1988-01-01

    Fiscal and strategic issues control healthcare policy in the United States, with questions of moral good drawing scant attention. A consequent need exists for policymakers and practitioners somewhere in the system to raise questions about the ultimate social goals of healthcare policy for the elderly. One approach to determining potential social goods is to examine standoffs that can occur between values. Should healthcare for the elderly be based on recompense for sociatal contributions, monetary and otherwise, or should it be based on need, disadvantage, and vulnerability? Should long-term care receive a greater share of the attention that now goes to acute care services? Should healthcare policy emphasize individual rights, needs, and resources, or society's priorities, needs, and resources? Our unreadiness to deal with questions of the ultimate good of healthcare for the elderly only promises ethical perplexity for the future. PMID:10285424

  7. A survey on question answering systems with classification

    Directory of Open Access Journals (Sweden)

    Amit Mishra

    2016-07-01

    Full Text Available Question answering systems (QASs generate answers of questions asked in natural languages. Early QASs were developed for restricted domains and have limited capabilities. Current QASs focus on types of questions generally asked by users, characteristics of data sources consulted, and forms of correct answers generated. Research in the area of QASs began in 1960s and since then, a large number of QASs have been developed. To identify the future scope of research in this area, the need of a comprehensive survey on QASs arises naturally. This paper surveys QASs and classifies them based on different criteria. We identify the current status of the research in the each category of QASs, and suggest future scope of the research.

  8. Workplace violence in victim surveys. : Same questions but different answers

    OpenAIRE

    Wikman, Sofia

    2014-01-01

    An analysis based on a comparison of three Swedish victim surveys examines violence at work on the basis of the questions on exposure to threats and violence. The questions that are included are very similar in all three of surveys: Statistics Sweden’s surveys of The Swedish population’s living conditions (ULF), Swedish Work Environment Authority’s survey The Work environment and Swedish National Council for Crime Prevention’s survey The Swedish Crime Survey (NTU). However the prevalence’s ar...

  9. APPRAISAL OF QUESTION CATEGORIZATION FOR AN ADAPTIVE ASSESSMENT IN ELEARNING

    OpenAIRE

    Kavitha, R.

    2011-01-01

    Due to the advancements in technology, e-learning plays a critical role in the field of advanced learning technologies. Each student is having their own way of learning and hence they cannot be assessed in unique way. In Intelligent Tutoring Systems, intellectual questions have to be given to the students. The objective here is to determine the item difficulties of questions to be posed in a test that are going to be used in e-learning. Computer Based Testing is used to collect user responses...

  10. Some open questions in the theory of generalized permutable subgroups

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    A subgroup H of a group G is said to be weakly s-supplemented in G if H has a supplement T in G such that H ∩ T HsG, where HsG is the largest s-permutable subgroup of G contained in H. This paper constructs an example to show that the open questions 6.3 and 6.4 in J Algebra, 315: 192–209 (2007) have negative solutions, and shows that in many cases Question 6.4 is positive. A series of known results are unified and generalized.

  11. Examinations for radiologists. 1250 examination questions, with comments

    International Nuclear Information System (INIS)

    The first section presents self-tests and learning tips for a realistic assessment and optimisation of students' learning styles. Rhetoric and communicative competences are looked into, and hints are given on how to organize ones's documents. The second section contains more than 1250 examination questions from all fields of radiology, with which examination situations can be simulated for self-studies. The student is shown how to provide structured answers to complex questions, how to solve clinical problems step by step, how to assess facts, to develop key statements, etc. (orig.)

  12. Dialogue in mathematics classrooms: Beyond question-and- answer methods

    Directory of Open Access Journals (Sweden)

    Karin Brodie

    2007-10-01

    Full Text Available This paper explores different kinds of interaction observed in South African mathematics classrooms in order to unpack the notion of participation in mathematics learning. It argues that conventional question-and-answer methods do not promote the kind of interaction that the new South African curriculum calls for. It presents more appropriate kinds of interactions, where teachers maintain high task demands, respond to genuine learner questions and support conversations among learners. The paper argues that combinations of different kinds of interaction are  most likely to support learner participation and mathematical thinking in classrooms.

  13. Multiple - Choice Questions And its Design In English Testing

    Institute of Scientific and Technical Information of China (English)

    曹佳蕾

    2005-01-01

    Multiple- choice tests give students the opportunity to select responses to test questions from among a number of specific choice. This format is efficient and practical. Carefully designed multiple- choice questions can provide valid information about student's knowledge and their ability to reason logically and apply complex thinking processes to solve problems. In this paper, the author explore the advantages and disadvantages of MCQ tests and suggest some useful tips for writing MCQs , the aim is to give some suggestions for improvement and use them more efficiently in our teaching and testing.

  14. On some questions of Fisk and Br\\"and\\'en

    CERN Document Server

    Yoshida, Rintaro

    2010-01-01

    P. Br\\"and\\'en recently proved a conjecture due to S. Fisk, R. P. Stanley, P. R. W. McNamara and B. E. Sagan. In addition, P. Br\\"and\\'en gave a partial answer to a question posed by S. Fisk regarding the distribution of zeros of polynomials under the action of certain non-linear operators. In this paper, we give an extension to a result of P. Br\\"and\\'en, and we also answer a question posed by S. Fisk.

  15. Have the Answers to Common Legal Questions Concerning Nutrition Support Changed Over the Past Decade? 10 Questions for 10 Years.

    Science.gov (United States)

    Barrocas, Albert; Cohen, Michael L

    2016-06-01

    Clinical nutrition specialists (CNSs) are often confronted with technological, ethical, and legal questions, that is, what can be done technologically, what should be done ethically, and what must be done legally, which conflict at times. The conflict represents a "troubling trichotomy" as discussed in the lead article of this issue of Nutrition in Clinical Practice (NCP). During Clinical Nutrition Week in 2006, a symposium covering these 3 topics was presented, and later that year, an article covering the same topic was published in NCP In this article, we revisit several legal questions/issues that were raised 10 years ago and discuss current answers and approaches. Some of the answers remain unchanged. Other answers have been modified by additional legislation, court decisions, or regulations. In addition, new questions/issues have arisen. Some of the most common questions regarding nutrition support involve the following: liability, informed consent, medical decisional incapacity vs legal competence, advance directive specificity, surrogate decision making, physician orders for life-sustaining treatment and electronic medical orders for life-sustaining treatment, legal definition of death, patient vs family decision making, the noncompliant patient, and elder abuse obligations. In the current healthcare environment, these questions and issues are best addressed via a transdisciplinary team that focuses on function rather than form. The CNS can play a pivotal role in dealing with these challenges by applying the acronym ACT: being Accountable and Communicating with all stakeholders while actively participating as an integral part of the transdisciplinary Team. PMID:27113077

  16. Have the Answers to Common Legal Questions Concerning Nutrition Support Changed Over the Past Decade? 10 Questions for 10 Years.

    Science.gov (United States)

    Barrocas, Albert; Cohen, Michael L

    2016-06-01

    Clinical nutrition specialists (CNSs) are often confronted with technological, ethical, and legal questions, that is, what can be done technologically, what should be done ethically, and what must be done legally, which conflict at times. The conflict represents a "troubling trichotomy" as discussed in the lead article of this issue of Nutrition in Clinical Practice (NCP). During Clinical Nutrition Week in 2006, a symposium covering these 3 topics was presented, and later that year, an article covering the same topic was published in NCP In this article, we revisit several legal questions/issues that were raised 10 years ago and discuss current answers and approaches. Some of the answers remain unchanged. Other answers have been modified by additional legislation, court decisions, or regulations. In addition, new questions/issues have arisen. Some of the most common questions regarding nutrition support involve the following: liability, informed consent, medical decisional incapacity vs legal competence, advance directive specificity, surrogate decision making, physician orders for life-sustaining treatment and electronic medical orders for life-sustaining treatment, legal definition of death, patient vs family decision making, the noncompliant patient, and elder abuse obligations. In the current healthcare environment, these questions and issues are best addressed via a transdisciplinary team that focuses on function rather than form. The CNS can play a pivotal role in dealing with these challenges by applying the acronym ACT: being Accountable and Communicating with all stakeholders while actively participating as an integral part of the transdisciplinary Team.

  17. The Rhetorical Question of Human Rights--A Preface

    Science.gov (United States)

    Doxtader, Erik

    2010-01-01

    Does rhetoric have a place in the discourse of human rights? Without certain reply, as the dilemmas of defining, claiming, and promoting human rights appear both to include and exclude the rhetorical gesture, this question invites inquiry into the preface of the contemporary human rights regime, the moment of the aftermath that provokes a struggle…

  18. Identification of Conflicting Questions in the PARES System

    Directory of Open Access Journals (Sweden)

    Avgoustos Tsinakos

    2012-06-01

    Full Text Available Student testing and knowledge assessment is a significant aspect of the learning process. In a number of cases, it is expedient not to present the exact same test to all learners all the time (Pritchett, 1999. This may be desired so that cheating in the exam is made harder to carry out or so that the learners can take several practice tests on the same subject as part of the course.This study presents an e-testing platform, namely PARES, which aims to provide assessment services to academic staff by facilitating the creation and management of question banks and powering the delivery of nondeterministically generated test suites. PARES uses a conflict detection algorithm based on the vector space model to compute the similarity between questions and exclude questions which are deemed to have an unacceptably large similarity from appearing in the same test suite. The conflict detection algorithm and a statistical evaluation of its accuracy are presented. Evaluation results show that PARES succeeds in detecting question types at about 90% and its efficiency can be further increased through continuing education and enrichment of the system’s correlation vocabulary.

  19. Disfluencies and gaze aversion in unreliable responses to survey questions

    NARCIS (Netherlands)

    Schober, Michael F.; Conrad, Frederick G.; Dijkstra, Wil; Ongena, Yfke P.

    2012-01-01

    When survey respondents answer survey questions, they can also produce "paradata" (Couper 2000, 2008): behavioral evidence about their response process. The study reported here demonstrates that two kinds of respondent paradata - fluency of speech and gaze direction during answers - identify answers

  20. Student Engagement Research in Higher Education: Questioning an Academic Orthodoxy

    Science.gov (United States)

    Zepke, Nick

    2014-01-01

    This article suggests that student engagement research is not often investigated critically. It attempts to change this. After briefly outlining a conceptual framework for student engagement, it explores three critical questions about it. First, it asks whether in trying to be all things in teaching and learning, student engagement focuses too…

  1. Theorizing the Entrepreneurial University: Open Questions and Possible Answers

    Science.gov (United States)

    Sotiris, Panagiotis

    2012-01-01

    This article attempts to address theoretical questions regarding the transition towards an entrepreneurial university and the changes associated with this process, namely the increased commodification, the competitive quest for private funding and the introduction of business management practices. The important theoretical advances made in the…

  2. Education, Schooling, Derrida's Marx and Democracy: Some Fundamental Questions

    Science.gov (United States)

    Peim, Nick

    2013-01-01

    Beginning with a reconsideration of what the school is and has been, this paper explores the idea of the school to come. Emphasizing the governmental role of education in modernity, I offer a line of thinking that calls into question the assumption of both the school and education as possible conduits for either democracy or social justice.…

  3. Three Questions about the Internet of Things and Children

    Science.gov (United States)

    Manches, Andrew; Duncan, Pauline; Plowman, Lydia; Sabeti, Shari

    2015-01-01

    Children's interaction with technology is evolving; increasingly there are devices that can capture and respond seamlessly to their everyday activity. This raises pertinent questions such as: how these technologies shape children's activity; how the data from their activity is used, and to what extent children, and their parents, are…

  4. Surveying Parental Mediation: Connections, Challenges and Questions for Media Literacy

    Science.gov (United States)

    Mendoza, Kelly

    2009-01-01

    This paper examines three strategies of parental mediation--coviewing, restrictive mediation, and active mediation--in order to make connections, challenge, and raise questions for media literacy. Coviewing, whether it is intentional practice, or whether it functions to promote media literacy, is explored. Restrictive mediation, how it connects to…

  5. Classroom Questioning Tendencies from the Perspective of Big Data

    Science.gov (United States)

    Lu, Wang; Rongxiao, Cai

    2016-01-01

    We are now living in an era of big data. From the perspective of data analysis of classroom questioning, the paper chooses three districts in City B that have significant differences. These are educationally developed District D, less developed District F, and developing District M. The study uses the stratified sampling method to choose from…

  6. Overview of the CLEF 2004 Multilingual Question Answering Track

    NARCIS (Netherlands)

    B. Magnini; A. Vallin; C. Ayache; G. Erbach; A. Penas; M. de Rijke; P. Rocha; K. Simov; R. Sutcliffe

    2005-01-01

    Following the pilot Question Answering Track at CLEF 2003, a new evaluation exercise for multilingual QA systems took place in 2004. This paper reports on the novelties introduced in the new campaign and on participants¿ results. Almost all the cross-language combinations between nine source languag

  7. Competence-Based Education and Training– about Frequently Asked Questions

    NARCIS (Netherlands)

    Mulder, M.

    2012-01-01

    This article follows the author's previous piece on practical guidelines for the development of comprehensive competence-based education and training (Mulder, 2012). It is about the questions that have been and are still frequently asked in presentations, workshops and classes about the introduction

  8. Effect of Lecture Instruction on Student Performance on Qualitative Questions

    Science.gov (United States)

    Heron, Paula R. L.

    2015-01-01

    The impact of lecture instruction on student conceptual understanding in physics has been the subject of research for several decades. Most studies have reported disappointingly small improvements in student performance on conceptual questions despite direct instruction on the relevant topics. These results have spurred a number of attempts to…

  9. Nuclear Power and the Environment--Questions and Answers.

    Science.gov (United States)

    Campana, Robert J.; Langer, Sidney

    This booklet has been developed to help the layman understand and evaluate the various efforts being undertaken to utilize nuclear power for the benefit of mankind. The question and answer format is utilized. Among the topics discussed are: Our Needs for Electricity; Sources of Radiation; Radiation from Nuclear Power Plants; Biological Effects of…

  10. The Ontogenesis of Question Words in Children's Language.

    Science.gov (United States)

    Johnson, Carolyn E.

    Questions asked in five play sessions by each of eight children aged 1.6 to 3.0 were analyzed for usage of the wh-interrogatives. About 93% of utterances using "what" and "where" were formulaic constructions (e.g., "Where's NP?" and "What's that thing?"). In order to determine whether children were cognitively segmenting these formulas and…

  11. Encouraging Citizenship in Science Education: Continuing Questions and Hopeful Possibilities

    Science.gov (United States)

    Blades, David

    2015-01-01

    This special issue of the "Canadian Journal of Science, Mathematics and Technology Education" invokes questions intended to further the discourse of citizenship in science and mathematics education, such as, How do we define "citizen" and "democracy"? Is our call for student action hypocritical? Does positioning…

  12. Hiring Savvy Teachers: Questions to Ask about Assessments

    Science.gov (United States)

    Trimble, Susan

    2006-01-01

    Hiring savvy teachers requires interviewers to assess more than candidates' willingness to do the job, love of students, and ability to fit into the climate of the school. Beyond these qualities, an important question remains and that is if the candidates have the assessment skills to be effective in this new age of test scores, accountability,…

  13. Time Advice and Learning Questions in Computer Simulations

    Science.gov (United States)

    Rey, Gunter Daniel

    2011-01-01

    Students (N = 101) used an introductory text and a computer simulation to learn fundamental concepts about statistical analyses (e.g., analysis of variance, regression analysis and General Linear Model). Each learner was randomly assigned to one cell of a 2 (with or without time advice) x 3 (with learning questions and corrective feedback, with…

  14. Infectious Mononucleosis in Active Patients: Definitive Answers to Common Questions.

    Science.gov (United States)

    Auwaerter, Paul G.

    2002-01-01

    Describes infectious mononucleosis (IM), examining viral transmission and infection, clinical features, diagnosis, and management. Focuses on answers to several commonly asked questions about IM in sport (e.g., when it is safe to resume sports after IM, how often fatigue or depression are related to earlier bouts of IM, and how often IM is…

  15. A Question of Evidence, or a Leap of Faith?

    Science.gov (United States)

    Howard, Jennifer

    2008-01-01

    Did he or didn't he? The question is vexing Coleridge scholars. Did the author of "Christabel," "Kubla Khan," and "The Rime of the Ancient Mariner" compose a blank-verse translation of Goethe's "Faust" that was published anonymously in London in 1821? Two prominent Romanticists, Frederick Burwick and James C. McKusick, both Americans, believe they…

  16. Six Questions about The World Bank's 2020 Education Sector Strategy

    Science.gov (United States)

    Shafiq, M. Najeeb

    2011-01-01

    Based on interviews with World Bank staff in April 2011, this article answers six questions about the World Bank's Education Sector Strategy 2020 (ESS 2020): (1) What is the ESS 2020? (2) What is it not? (3) How was the development process of the ESS 2020 different from that of past Strategies? (4) How are the policy recommendations of the ESS…

  17. Validating Two Questions in the Force Concept Inventory with Subquestions

    Science.gov (United States)

    Yasuda, Jun-ichiro; Taniguchi, Masa-aki

    2013-01-01

    In this study, we evaluate the structural validity of Q.16 and Q.7 in the Force Concept Inventory (FCI). We address whether respondents who answer Q.16 and Q.7 correctly actually have an understanding of the concepts of physics tested in the questions. To examine respondents' levels of understanding, we use subquestions that test them on concepts…

  18. Are Professors Professionals? A Fresh Look at This Question

    Science.gov (United States)

    Newlyn, David

    2015-01-01

    Are university educators professionals? Whether or not university educators should be regarded as professionals is an important question that has an impact on a number of issues including job satisfaction, societal status and salary levels. This paper examines the need to classify this group as a profession and the consequences of that…

  19. Modelling Question Difficulty in an A Level Physics Examination

    Science.gov (United States)

    Crisp, Victoria; Grayson, Rebecca

    2013-01-01

    "Item difficulty modelling" is a technique used for a number of purposes such as to support future item development, to explore validity in relation to the constructs that influence difficulty and to predict the difficulty of items. This research attempted to explore the factors influencing question difficulty in a general qualification…

  20. 37 CFR 354.1 - Material questions of copyright law.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Material questions of copyright law. 354.1 Section 354.1 Patents, Trademarks, and Copyrights COPYRIGHT ROYALTY BOARD, LIBRARY OF CONGRESS COPYRIGHT ROYALTY JUDGES RULES AND PROCEDURES SUBMISSIONS TO THE REGISTER OF COPYRIGHTS §...

  1. Addressing Parental Vaccination Questions in the School Setting

    Science.gov (United States)

    Luthy, Karlen E.; Burningham, Jana; Eden, Lacey M.; Macintosh, Janelle L. B.; Beckstrand, Renea L.

    2016-01-01

    School nurses work in a unique environment with key opportunities to address parental concerns and questions regarding their child's health. A common concern for parents during school enrollment is childhood vaccination safety and efficacy. As public health leaders, school nurses are well respected among parents, therefore school nurses are in a…

  2. Two Questions for Sociologists of Education: A Rejoinder

    Science.gov (United States)

    Downey, Douglas B.; Condron, Dennis J.

    2016-01-01

    The commentaries on Downey and Condron found in this issue help advance an overdue conversation about schools and inequality. This paper considers two questions that are prompted by the comments from the authors' colleagues: (1) Would we make more progress reducing socio-economic and racial achievement gaps by reforming schools or by reforming the…

  3. Clinical Research Trials and You: Questions and Answers

    Science.gov (United States)

    ... of clinical research is to develop knowledge that improves human health or increases understanding of human biology. People who ... answer any questions from my insurance company or health plan? Will there be any travel or child care costs that I need to ...

  4. Asking the Right Questions about Leadership: Discussion and Conclusions

    Science.gov (United States)

    Hackman, J. Richard; Wageman, Ruth

    2007-01-01

    Five questions prompted by the articles in the American Psychologist special issue on leadership (January 2007, Vol. 62, No. 1) suggest some new directions for leadership research: (1) Not do leaders make a difference, but under what conditions does leadership matter? (2) Not what are the traits of leaders, but how do leaders' personal attributes…

  5. Secondary Data Analysis: An Important Tool for Addressing Developmental Questions

    Science.gov (United States)

    Greenhoot, Andrea Follmer; Dowsett, Chantelle J.

    2012-01-01

    Existing data sets can be an efficient, powerful, and readily available resource for addressing questions about developmental science. Many of the available databases contain hundreds of variables of interest to developmental psychologists, track participants longitudinally, and have representative samples. In this article, the authors discuss the…

  6. On the Charter Question: Black Marxism and Black Nationalism

    Science.gov (United States)

    Stern, Mark; Hussain, Khuram

    2015-01-01

    This article brings two black intellectual traditions to bear on the question of charter schools: black Marxism and black nationalism. The authors examine the theoretical and rhetorical devices used to talk about charters schools by focusing on how notions of "black liberation" are deployed by the charter movement, and to what end. The…

  7. The Question of Teaching Vocabulary: Which Words? In What Ways?

    Science.gov (United States)

    Wilhelm, Jeffrey D., Ed.

    2013-01-01

    Recognizing the importance of vocabulary for comprehension, Wilhelm asks two key questions: "which words do I teach and how should I teach them?" Through years of trial and error, Wilhelm has adopted these principles to answer "which words": teach "important" words students will see and use again; words necessary to conceptual understanding; words…

  8. Begging the Question: Performativity and Studio-Based Research

    Science.gov (United States)

    Petelin, George

    2014-01-01

    The requirement that candidates in studio-based or practice-led higher degrees by research should formulate a research question has been found to be problematic by some writers. The present article argues that this stance, particularly as it is articulated by proponents of the influential category of "performative research" (Haseman,…

  9. Ask Marilyn in the Mathematics Classroom: Probability Questions

    Science.gov (United States)

    Vasko, Francis J.

    2012-01-01

    Since 1986, Marilyn Vos Savant, who is listed in the "Guinness Book of World Records Hall of Fame" for the highest IQ, has had a weekly column that is published in "Parade Magazine." In this column, she answers readers' questions on a wide variety of subjects including mathematics and particularly probability. Many of the mathematically oriented…

  10. Question Answering for Collaborative Learning with Answer Quality Predictor

    Directory of Open Access Journals (Sweden)

    Kohei Arai

    2013-06-01

    Full Text Available The increasing advances of Internet Technologies in all application domains have changed life styles and interactions. With the rapid development of E-Learning, collaborative learning is an important for teaching, learning methods and strategies. Studies over the years shown that students had actively and more interactively involved in a classroom discussion to gain their knowledge. Students can ask their questions to the classroom discussion when they want to collaborate with others, asking one another for information, evaluating one another’s ideas. Therein, the activity allowing one question has many answer or information that should be selected. Every answer has a weighting and its very subjective to select it. In this paper, we introduce question answering for collaborative learning with answer quality predictor. By using answer quality predictor the quality of the information could be determined. Through the process of collaborative learning, the knowledge base will be enriched for future question answering. Further, not only the student could get answers form others but also provided by the system.

  11. Gay, Lesbian, Bisexual, Transgender and Questioning Youth Matter!

    Science.gov (United States)

    King, Kathleen A.

    2009-01-01

    This brief presents general trends in the social and emotional well-being of youth who identify as Gay, Lesbian, Bisexual, Transgender, and Questioning (GLBTQ), followed by a guide of sexual orientation definitions. Additionally, readers learn a series of steps that schools must address in order to build inclusive, safe, and effective schools for…

  12. Service Accessibility for Lesbian, Gay, Bisexual, Transgender, and Questioning Youth

    Science.gov (United States)

    Acevedo-Polakovich, Ignacio David; Bell, Bailey; Gamache, Peter; Christian, Allison S.

    2013-01-01

    Although Lesbian, Gay, Bisexual, Transgender, Queer and/or Questioning (LGBTQ) youth experience alarming rates of behavioral and social problems, service use among these youth is disproportionately low. It is likely that decreased service accessibility plays a causal role in service underutilization among LGBTQ youth. To expand the existing…

  13. Living the Questions: Rilke's Challenge to Our Quest for Certainty

    Science.gov (United States)

    Gordon, Mordechai

    2007-01-01

    In this essay, Mordechai Gordon explores the significance of Rilke's challenge to "live the questions" and embrace uncertainty with respect to the quest for certainty in education. The quest for certainty in education refers to our desire to gain a sense of psychological security and more control over a field that is fundamentally indeterminate.…

  14. Questions Students Ask: The Red-Eye Effect.

    Science.gov (United States)

    Physics Teacher, 1985

    1985-01-01

    Addresses the question of why a dog's eyes appear red and glow when a flash photograph is taken. Conditions for the red-eye effect, light paths involved, structure of the eye, and typical cameras and lenses are discussed. Also notes differences between the eyes of nocturnal animals and humans. (JN)

  15. The Incoherence of Curriculum: Questions Concerning Early Childhood Teacher Educators

    Science.gov (United States)

    Gibbons, Andrew N.

    2011-01-01

    This paper examines curriculum debates, particularly those that influence an understanding of the nature and purpose of curriculum, in providing teacher education and in influencing teaching practice. The work of Martin Heidegger provides a framework for questioning the early childhood teacher education curriculum. Central to this analysis are…

  16. Questions Arising from the Assessment of EFL Narrative Writing

    Science.gov (United States)

    Yi, Yong

    2013-01-01

    This article questions how narrative writing is assessed, seeking to understand what we test, what we value, and why. It uses a single anomalous case that arose in the course of my recent PhD thesis to highlight the issues, asking if sufficient attention is being given to the value of emotional content in a piece of writing in comparison to its…

  17. Re-Teaching Shakespeare (i): "Macbeth" and the "Witchcraft" Question.

    Science.gov (United States)

    Williams, Michael

    1989-01-01

    Describes a classroom study of Shakespeare's "Macbeth" which concentrates on the Weird Sisters and the question of witchcraft. Advocates utilizing pupils' experience of powerful images from the general culture, introducing a selection of well-documented historical evidence to support textual study, and avoiding misguided conventional wisdom…

  18. Corporal Punishment and Teacher Liability: Questions Teachers Ask.

    Science.gov (United States)

    McDaniel, Thomas R.

    1980-01-01

    The author answers some of the central questions--legal and pedagogical--relating to the use of corporal punishment by teachers. He presents guidelines on corporal punishment which can reduce the likelihood of liability, but suggests, given the potential for lawsuits, that teachers adopt alternative forms of discipline. (Author/SJL)

  19. Big Questions Facing Vocational Psychology: A Cognitive Information Processing Perspective

    Science.gov (United States)

    Reardon, Robert C.; Lenz, Janet G.; Sampson, James P., Jr.; Peterson, Gary W.

    2011-01-01

    This article draws upon the authors' experience in developing cognitive information processing theory in order to examine three important questions facing vocational psychology and assessment: (a) Where should new knowledge for vocational psychology come from? (b) How do career theories and research find their way into practice? and (c) What is…

  20. A token of individuality : Questiones libri Porphirii by Thomas Manlevelt

    NARCIS (Netherlands)

    Helm, Alfred Charles van der

    2012-01-01

    This is a critical edition with introduction and indices of the Questiones libri Porphirii, a commentary on Porphyry’s Isagoge attributed to the fourteenth-century logician Thomas Manlevelt. Not much is known about Thomas Manlevelt, but his work is remarkable enough. Following in the footsteps of