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Sample records for ciuplys jonas vilys

  1. Kadunud vili ja Eesti haldussuutlikkus / Kaul Nurm

    Index Scriptorium Estoniae

    Nurm, Kaul

    2004-01-01

    Teravilja julgeolekuvaru kadumise tagajärjed ja õppetunnid Euroopa Liidu poolt vaadatuna. Autori arvates oleks olnud vili alles, kui põllumajandusminister Tiit Tammsaar oleks kasutanud oma aega enda valitsemisalas riigi haldussuutlikkuse tõstmisele

  2. JONAS, HANS, Memorias. Por Juan Arana

    Directory of Open Access Journals (Sweden)

    Juan Arana

    2012-05-01

    Full Text Available Autor: Hans Jonas (2005. Editorial: Losada, Madrid. Traducción: Illana Giner Comín. Basadas en las conversaciones con Rachel Salamander. Proemiode Lore Jonas. Prólogo de Rachel Salamander. Editor: Christian Wiese. Hans Jonas forma parte, con Koestler,Popper, Heidegger o Wittgenstein, del selecto grupo de pensadores y escritores a quienes tocó vivir en primera persona gran parte de las peripecias del turbulento siglo XX. Pero, como en todo, hay diferencias.La trayectoria vital de Jonas no dibuja el perfil de una desmesura excéntrica, como la de Wittgenstein, ni de una tenaz ambición teórica, como la de Popper, ni de un lamentable olvido del prójimo, como la de Heidegger, ni de un aventurismo desquiciado, como la de Koestler.

  3. APRV Mode in Ventilator Induced Lung Injury (VILI

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    Ata Mahmoodpoor

    2014-01-01

    Full Text Available Ventilator-Induced Lung Injury (VILI, being a significant iatrogenic complication in the ICU patients, is associated with high morbidity and mortality. Numerous approaches, protocols and ventilation modes have been introduced and examined to decrease the incidence of VILI in the ICU patients. Airway pressure release ventilation (APRV, firstly introduced by Stock and Downs in 1987, applies higher Continuous Positive Airway Pressure (CPAP levels in prolonged periods (P and T high in order to preserve satisfactory lung volume and consequently alveolar recruitment. This mode benefits a time-cycled release phase to a lower set of pressure for a short period of time (P and T low i.e. release time (1,2. While some advantages have been introduced for APRV such as efficiently recruited alveoli over time, more homogeneous ventilation, less volutrauma, probable stabilization of patent alveoli and reduction in atelectrauma, protective effects of APRV on lung damage only seem to be substantial if spontaneous breathing responds to more than 30% of total minute ventilation (3. APRV in ARDS patients should be administered cautiously; T low<0.6 seconds, for recruiting collapsed alveoli; however overstretching of alveoli especially during P high should not be neglected and appropriate sedation considered. The proposed advantages for APRV give the impression of being outstanding; however, APRV, as a non-physiologic inverse ratio mode of ventilation, might result in inflammation mainly due to impaired patient-ventilator interaction explaining the negative or minimally desirable effects of APRV on inflammation (4. Consequently, continuous infusion of neuromuscular blocking drugs during ARDS has been reported to reduce mortality (5. There are insufficient confirming data on the superiority of APRV above other ventilatory methods in regard to oxygenation, hemodynamics, regional blood flow, patient comfort and length of mechanical ventilation. Based on current findings

  4. Nino, lihtsalt Nino - ilma igasuguse priimata / Nino Ananiašvili ; intervjueerinud Tiit Tuumalu

    Index Scriptorium Estoniae

    Ananiašvili, Nino, 1963-

    2011-01-01

    9. ja 10. veebruaril toimuvad Eestis Gruusia Riikliku Balleti etendused, Gruusia balletitantsija Nino Ananiašvili räägib intervjuus Gruusia balletist ja ka emotsionaalsetest suhetest Eestiga, Venemaaga

  5. Jonas Olson's Evidence for Moral Error Theory

    NARCIS (Netherlands)

    Evers, Daan

    2016-01-01

    Jonas Olson defends a moral error theory in (2014). I first argue that Olson is not justified in believing the error theory as opposed to moral nonnaturalism in his own opinion. I then argue that Olson is not justified in believing the error theory as opposed to moral contextualism either (although

  6. Tobias, Rudolf: Des Jona Sendung / Olivier Opdebeeck

    Index Scriptorium Estoniae

    Opdebeeck, Olivier

    1996-01-01

    Uuest heliplaadist "Tobias, Rudolf: Des Jona Sendung. Pille Lill (soprano), Urve Tauts (mezzo-soprano), Peter Svensson (tenor), Raimo Laukka (baryton), Mati Palm (basse); Choeur d'Oratorio, Choeur de chambre Philharmonique d'Estonie, Choeur de garcons de Tallinn, Orchestre Symphonique d'Etat d'Estonie, Neeme Järvi" BIS CD-731/732, distribution Arcade 8000 716 (2 CD: 290F). TT: 1h 54'13"

  7. [Hans Jonas: Nature Conservation, Conservation of Life].

    Science.gov (United States)

    Burgui Burgui, Mario

    2015-01-01

    This article discusses three of the problems that the German philosopher Hans Jonas studied. The first one addresses the need for a specific ethic dedicated to the moral dimension of environmental problems, from a different perspective to the traditional. The second problem is crucial in the discussion on environmental ethics: the value of the nature. Does the nature have an intrinsic value or an instrumental value only (to satisfy the interests of the human being)? The thesis of Jonas, which claimed that nature is a good in itself, were further elaborated here. And the third problem is the derivation of moral norms and the role of man in this ethic that recognizes a good in itself in nature. According to Jonas, the human being is not diminished by recognizing the intrinsic value of nature, since the man's uniqueness and value are unquestionable. From these three central issues, the paper highlights the importance of seeking the links between bioethics and environmental ethics to address the current environmental, social and economic crisis.

  8. [Vilis Kolms. Das Rigaer Gesangbuch und die kirchenordnung von 1530]/ Dennis Hortmuth

    Index Scriptorium Estoniae

    Hormuth, Dennis

    2012-01-01

    Arvustus: .Vilis Kolms. Das Rigaer Gesangbuch und die kirchenordnung von 1530. In: Die baltischen Lande im Zeitalter der Reformation und Konfessionaliesierung. Livland, Estland, Ösel, Ingermanland, Kurland und Lettgallen. Stadt, Land und Konfession 1500-1721. Teil 2 (=Katholisches Leben und Kirchenreform im Zeitalter der Glaubensspaltung 70). Münster, 2010. S. 175-190

  9. ILALOK. Dictionnaire vili–français/Mpisukulu bi kum' bi tshi vili ku tshi mputu.

    Directory of Open Access Journals (Sweden)

    P.A. Mavoungou

    2011-10-01

    Full Text Available On connaît le vif intérêt de l'Institut des Langues Locales au Kouilou pour la promotion des langues maternelles et des cultures dont elles sont le véhicule irremplaçable. La parution aux Éditions L'Harmattan du Dictionnaire vili–fran-çais en 2008 vient couronner des années d'efforts acharnés et de privations. Ce dictionnaire, consacré au civili, poursuit ainsi la tradition des ouvrages lexico-graphiques commencés par les missionnaires. Pour le civili notamment on peut citer les contributions des révérends pères Derouet (n.d. et Marichelle (1902 qui furent imprimés à la vieille imprimerie de Loango. Dans la préface du Dic-tionnaire vili–français (en abrégé DVF dans le reste du texte, le R.P. Marichelle précise que la parution de son dictionnaire vient compléter l'oeuvre du R.P. Derouet auteur du Dictionnaire français–vili. Hormis les travaux lexicographi-ques sur le civili, deux autres ouvrages ont également été publiés. Il s'agit de Proverbes et dictons du Loango en Afrique Centrale de René Mavoungou Pambou (1997 et de Parlons vili de Gervais Loembé (2005. La parution du Dictionnaire vili–français complète parfaitement bien cette série.

  10. Nambu-Jona-Lasinio model with Wilson fermions

    DEFF Research Database (Denmark)

    Rantaharju, Jarno; Drach, Vincent; Pica, Claudio

    2017-01-01

    We present a lattice study of a Nambu-Jona-Lasinio (NJL) model using Wilson fermions. Four-fermion interactions are a natural part of several extensions of the Standard Model, appearing as a low-energy description of a more fundamental theory. In models of dynamical electroweak symmetry breaking...

  11. VIA/VILI is more suitable for cervical cancer prevention in Chinese poverty-stricken region: a health economic evaluation.

    Science.gov (United States)

    Xie, Yu; Tan, Xiaodong; Shao, Haiyan; Liu, Qing; Tou, Jiyu; Zhang, Yuling; Luo, Qiong; Xiang, Qunying

    2017-01-25

    Screening is the main preventive method for cervical cancer in developing countries, but each type of screening has advantages and disadvantages. To investigate the most suitable method for low-income areas in China, we conducted a health economic analysis comparing three methods: visual inspection with acetic acid and Lugol's iodine (VIA/VILI), ThinPrep cytology test (TCT), and human papillomavirus (HPV) test. We recruited 3086 women aged 35-65 years using cluster random sampling. Each participant was randomly assigned to one of three cervical cancer screening groups: VIA/VILI, TCT, or HPV test. In order to calculate the number of disability-adjusted life years (DALYs) averted by each screening method, we used Markov models to estimate the natural development of cervical cancer over a 15-year period to estimate the age of onset and duration of each disease stage. The cost-effectiveness ratios (CERs), net present values (NPVs), benefit-cost ratios (BCRs), and cost-utility ratios (CURs) were used as outcomes in the health economic analysis. The positive detection rate in the VIA/VILI group was 1.39%, which was 4.6 and 2.0 times higher than the rates in the TCT and HPV test groups, respectively. The positive predictive value of VIA/VILI (10.53%) was highest while the rate of referral for colposcopy was lowest for those in the HPV + TCT group (0.60%). VIA/VILI performed the best in terms of health economic evaluation results, as the cost of per positive case detected was 8467.9 RMB, which was 24503.0 RMB lower than that for TCT and 5755.9 RMB lower than that for the HPV test. In addition, the NPV and BCR values were 258011.5 RMB and 3.18 (the highest), and the CUR was 2341.8 RMB (the lowest). The TCT performed the worst, since its NPV was <0 and the BCR was <1, indicative of being poorly cost-beneficial. With the best economic evaluation results and requiring minimum medical resources, VIA/VILI is recommended for cervical cancer screening in poverty-stricken areas

  12. VIA/VILI is more suitable for cervical cancer prevention in Chinese poverty-stricken region: a health economic evaluation

    Directory of Open Access Journals (Sweden)

    Yu Xie

    2017-01-01

    Full Text Available Abstract Background Screening is the main preventive method for cervical cancer in developing countries, but each type of screening has advantages and disadvantages. To investigate the most suitable method for low-income areas in China, we conducted a health economic analysis comparing three methods: visual inspection with acetic acid and Lugol’s iodine (VIA/VILI, ThinPrep cytology test (TCT, and human papillomavirus (HPV test. Methods We recruited 3086 women aged 35–65 years using cluster random sampling. Each participant was randomly assigned to one of three cervical cancer screening groups: VIA/VILI, TCT, or HPV test. In order to calculate the number of disability-adjusted life years (DALYs averted by each screening method, we used Markov models to estimate the natural development of cervical cancer over a 15-year period to estimate the age of onset and duration of each disease stage. The cost-effectiveness ratios (CERs, net present values (NPVs, benefit-cost ratios (BCRs, and cost-utility ratios (CURs were used as outcomes in the health economic analysis. Results The positive detection rate in the VIA/VILI group was 1.39%, which was 4.6 and 2.0 times higher than the rates in the TCT and HPV test groups, respectively. The positive predictive value of VIA/VILI (10.53% was highest while the rate of referral for colposcopy was lowest for those in the HPV + TCT group (0.60%. VIA/VILI performed the best in terms of health economic evaluation results, as the cost of per positive case detected was 8467.9 RMB, which was 24503.0 RMB lower than that for TCT and 5755.9 RMB lower than that for the HPV test. In addition, the NPV and BCR values were 258011.5 RMB and 3.18 (the highest, and the CUR was 2341.8 RMB (the lowest. The TCT performed the worst, since its NPV was <0 and the BCR was <1, indicative of being poorly cost-beneficial. Conclusions With the best economic evaluation results and requiring minimum medical resources, VIA/VILI is

  13. Topological solitons of the Nambu-Jona-Lasinio model

    International Nuclear Information System (INIS)

    Reinhardt, H.; Wuensch, R.

    1989-06-01

    The baryon number one soliton solution of the Nambu-Jona-Lasinio model are found numerically in the mean-field approximation with full inclusion of the Dirac sea using the proper-time regularization for the underlying fermion determinant (quark loop). Explicit breaking of chiral symmetry is included by bare (current) quark masses. The obtained lowest-energy chiral soliton solutions with baryon number one carry winding number one. Fitting the parameters of the model from low-energy pion data the classical energies of these solitons are of the order of the nucleon mass. (orig.)

  14. Hans Jonas' thought on the ethics of research on human subjects ...

    African Journals Online (AJOL)

    Hans Jonas' thought on the ethics of research on human subjects and its implications for contemporary medical research in Nigeria was examined. The thinking and teachings of Hans Jonas was on the need for medical research to advance beyond the use animals for research and experimentations to research on human ...

  15. Review of the Czubek--Jonas gamma-log program

    International Nuclear Information System (INIS)

    Matthews, M.

    1978-11-01

    Several gamma-ray logs were computer processed using the Czubek--Jones and DOE's MDDAT gamma-log programs. Both of these programs convert counts per second from the gamma-ray logs to percent eU 3 O 8 . The results of these programs were compared to each other and to the core analysis (percent U 3 O 8 ) of the logged boreholes. The two gamma-log programs produced similar results. The core analysis did not compare favorably with the results of either gamma-log program. This unfavorable comparison is probably due to an incorrect assumption of secular equilibrium for the ore surrounding the boreholes. The Czubek--Jonas program requires a knowledge of the linear attenuation coefficient of the rocks surrounding a borehole. This limits the usefulness of the program because this coefficient is generally not known and varies for different gamma-ray energies. It is recommended that the MDDAT program continue to be used for estimating the grade (percent eU 3 O 8 ) from gamma-log data and not be replaced by the Czubek--Jonas program

  16. EL PRINCIPIO DE RESPONSABILIDAD DE HANS JONAS O PRINCÍPIO DE RESPONSABILIDADE DE HANS JONAS HANS JONAS’ PRINCIPLE OF RESPONSIBILITY

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    José Eduardo de Siqueira

    2001-01-01

    Full Text Available Este trabajo es una reflexión sobre la principal obra del filósofo alemán contemporáneo, Hans Jonas. Muestra la trayectoria intelectual de Jonas hasta llegar al rescate de la ética de la responsabilidad, que Max Weber sugiere en obras de comienzos del siglo. El Principio de la Responsabilidad de Jonas es una evaluación sumamente crítica de la ciencia moderna y de su "brazo armado", la tecnología. El filósofo muestra la necesidad que el ser humano tiene de actuar con cautela y humildad frente al enorme poder transformador de la tecnocienciaEste trabalho é uma reflexão sobre a principal obra do filósofo alemão contemporâneo, Hans Jonas. Apresenta a trajetória intelectual de Jonas até o resgate da ética da responsabilidade que Max Weber sugere em obras do começo do século XX. O Princípio da Responsabilidade de Jonas é uma apreciação extremamente crítica da ciência moderna e de seu "braço armado", a tecnologia. O filósofo mostra que é necessário o ser humano agir com cautela e humildade ante o enorme poder transformador da tecnociênciaThis paper is a reflection on the main work of the german philosopher Hans Jonas. It shows his intellectual trajectory till the point of the rescueing of the ethics of responsibility, suggested in Max Weber ’s works of the beginning of this century. Jonas’ principle of responsibility is an extremely critical analysis of modern science and its principal "armed arm", technology. The philosopher expounds the need all human beings have to act with caution and humility in face of the tremendous transforming power technoscience posseses

  17. Nambu-Jona-Lasinio model in a parallel electromagnetic field

    Science.gov (United States)

    Wang, Lingxiao; Cao, Gaoqing; Huang, Xu-Guang; Zhuang, Pengfei

    2018-05-01

    We explore the features of the UA (1) and chiral symmetry breaking of the Nambu-Jona-Lasinio model without the Kobayashi-Maskawa-'t Hooft determinant term in the presence of a parallel electromagnetic field. We show that the electromagnetic chiral anomaly can induce both finite neutral pion condensate and isospin-singlet pseudo-scalar η condensate and thus modifies the chiral symmetry breaking pattern. In order to characterize the strength of the UA (1) symmetry breaking, we evaluate the susceptibility associated with the UA (1) charge. The result shows that the susceptibility contributed from the chiral anomaly is consistent with the behavior of the corresponding η condensate. The spectra of the mesonic excitations are also studied.

  18. Hans Jonas' thought on the ethics of research on human subjects

    African Journals Online (AJOL)

    Dr Olaleye

    use animals for research and experimentations to research on human subjects. Jonas upholds the ..... examples of ethical theory, the less said about it the better. But what is allowable .... Also, man seeks self-gratification and self- promotion.

  19. A proposal of a renormalizable Nambu-Jona-Lasinio model

    Science.gov (United States)

    Cabo Montes de Oca, Alejandro

    2018-03-01

    A local and gauge invariant gauge field model including Nambu-Jona-Lasinio (NJL) and QCD Lagrangian terms in its action is introduced. Surprisingly, it becomes power counting renormalizable. This occurs thanks to the presence of action terms which modify the quark propagators, to become more decreasing that the Dirac one at large momenta in a Lee-Wick form, implying power counting renormalizability. The appearance of finite quark masses already in the tree approximation in the scheme is determined by the fact that the new action terms explicitly break chiral invariance. In this starting work we present the renormalized Feynman diagram expansion of the model and derive the formula for the degree of divergence of the diagrams. An explanation for the usual exclusion of the added Lagrangian terms is presented. In addition, the primitíve divergent graphs are identified. We start their evaluation by calculating the simpler contribution to the gluon polarization operator. The divergent and finite parts both result transverse as required by gauge invariance. The full evaluation of the various primitive divergences, which are required for completely defining the counterterm Feynman expansion will be considered in coming works, for further allowing to discuss the flavour symmetry breaking and unitarity.

  20. Hans Jonas: The Principle Responsability, Limits of Research (? and Nanotechnologies

    Directory of Open Access Journals (Sweden)

    Patricia Santos Martins

    2015-12-01

    Full Text Available The study intends to carry out the reading of the responsibility principle and the new ethical model narrated by Hans Jones to nanotechnology context. Study the historical context of political and economic development and the interrelations with technological development, visiting the transformation of homo sapiens - homo faber - homo tecnologicus. Check if operating at the nanoscale, comprised in the billionth of meter, has elements that may indicate possible damage that might compromise or offer risks to the exercise of rights for future generations. Therefore, we intend to find points of convergence between the management of the potential risks of nanotechnologies and the new ethical model proposed by Hans Jonas in his work "The principle responsibility test an ethics for technological civilization". The study sheds bases in the work cited as theoretical foundation for the study and is based on the notion of risk proposed by Niklas Luhmann, and uses the method of literature refers to these works as well as published articles involving the topics covered.

  1. CRYOTHERAPY FOLLOWING VISUAL INSPECTION WITH ACETIC ACID AND LUGOL'S IODINE (VIA/VILI) IN KHWISERO, WESTERN KENYA: LESSON FROM THE FIELD AFFECTING POLICY AND PRACTICE.

    Science.gov (United States)

    Ngichabe, S K; Muthaura, P N; Murungi, C; Muyoka, J; Omenge, E; Muchiri, L

    2013-10-01

    Cervical cancer can be prevented and mortality/morbidity reduced by early detection and referral. Developing countries are likely to benefit from more cost effective methods of screening and treatment. Visual inspection with acetic acid and Lugol's iodine (VIA/VILI) offers a see and treat solution thus an affordable and efficient way to identify pre-malignant lesions. Immediate treatment with cryotherapy can be offered if pre-malignant lesions are found on visual inspection. Cryotherapyis a simple procedure that is curative for dysplasia; it is likely to benefit cervical dysplasia cases picked early in resource poor settings, however there are several factors that hinder patients' access to this noble technique. Determine hindrances to cryotherapy for patients following positive results of VIA/VILI after referral. Cross sectional Study Khwisero, Western Kenya. Women attending a medical camp, willing to get screened for cervical cancer. One hundred and nine patients were screened; seventy three (66.97%) were negative for VIA/VILI, twenty one (19.26%) were positive and referred for cryotherapy. Reasons for lack of follow up were financial constraints, lack of medical personnel at referral centres and poor access to the referral facilities.19.26% of women identified with positive lesions required intervention. No patient received cryotherapy following referral. There is urgent need for availability of cryotherapy machines and training of personnel who can perform cryotherapy at the primary care level. Regional studies on knowledge attitudes and practices about VIA/VILI and cryotherapy are required to provide reasons for the poor uptake of this procedure.

  2. Als Jona drei Tage im Walfisch war oder: Vom Zähneputzen!

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    Ballhorn, Egbert

    2017-11-01

    Full Text Available The paper takes a case study about a correlatively oriented teaching unit on Jona in primary school as its starting point. This case study clearly shows the difficulties which correlative Bible Didactics have to face. However, it also illustrates the chances of working with the book of Jona on an intertextual basis. Based on this case study, the theoretical main features of intertextual exegesis shall be presented here. This should then lead to the development of requirements and challenges for intertextually oriented learning processes.

  3. Jona Willem te Water (1740-1822) : historicus en theoloog tussen traditie en Verlichting

    NARCIS (Netherlands)

    Mooij, Jacobus Daniël de

    2008-01-01

    Jona Willem te Water (1740-1822), a professor at Leiden University, was a man of influence in the Dutch Reformed Church, in many learned societies, in academic theology, and in Dutch historiography. He started his career as a Reformed minister in the province of Zeeland. His main historiographical

  4. Dexmedetomidine reduces ventilator-induced lung injury (VILI by inhibiting Toll-like receptor 4 (TLR4/nuclear factor (NF-κB signaling pathway

    Directory of Open Access Journals (Sweden)

    Hongli Chen

    2018-02-01

    Full Text Available Mechanical ventilation (MV may lead to ventilator-induced lung injury (VILI. Previous research has shown that dexmedetomidine attenuates pulmonary inflammation caused by MV, but the underlying mechanisms remain unclear. Our study aims to test whether dexmedetomidine has a protective effect against VILI and to explore the possible molecular mechanisms using the rat model. Thirty adult male Wistar rats weighing 200-250 g were randomly assigned to 5 groups (n = 6: control, low tidal volume MV (LMV, high tidal volume (HVT MV (HMV, HVT MV + dexmedetomidine (DEX, HVT MV + dexmedetomidine + yohimbine (DEX+Y. Rats were euthanized after being ventilated for 4 hours. Pathological changes, lung wet/dry (W/D weight ratio, lung myeloperoxidase (MPO activity, levels of inflammatory cytokines (i.e., interleukin [IL]-1β, tumor necrosis factor alpha [TNF-α], and IL-6 in the bronchoalveolar lavage fluid (BALF and lung tissues, expression of Toll-like receptor 4 (TLR4 and nuclear factor (NF-κB, and activation of NF-κB in lung tissues were measured. Compared with HMV, DEX group showed fewer pathological changes, lower W/D ratios and decreased MPO activity of the lung tissues and lower concentrations of the inflammatory cytokines in the BALF and lung tissues. Dexmedetomidine significantly inhibited the expression of TLR4 and NF-κB and activation of NF-κB. Yohimbine partly alleviated the effects of dexmedetomidine. Dexmedetomidine reduced the inflammatory response to HVT-MV and had a protective effect against VILI, with the inhibition of the TLR4/NF-κB signaling pathway, at least partly via α2-adrenoceptors.

  5. QCD-motivated Nambu-Jona-Lasinio model with quark and gluon condensates

    International Nuclear Information System (INIS)

    Ebert, D.; Volkov, M.K.

    1991-01-01

    A systematic study of the role of the nonperturbative gluon condensate arising in a QCD-motivated Nambu-Jona-Lasinio model is presented. The effects of the gluon condensate on induced meson couplings, the pion decay constant, quark condensate and mass formulae are investigated. An interesting result is the change of the scale Λ of chiral symmetry breaking and of the universal four-quark coupling constant κ. 20 refs

  6. Pion transverse momentum dependent parton distributions in the Nambu and Jona-Lasinio model

    Energy Technology Data Exchange (ETDEWEB)

    Noguera, Santiago [Departament de Fisica Teòrica and IFIC, Universitat de València - CSIC,E-46100 Burjassot (Spain); Scopetta, Sergio [Dipartimento di Fisica e Geologia, Università degli Studi di Perugia,via A. Pascoli, I - 06123 Perugia (Italy); Istituto Nazionale di Fisica Nucleare, Sezione di Perugia, via A. Pascoli, I - 06123 Perugia (Italy)

    2015-11-16

    An explicit evaluation of the two pion transverse momentum dependent parton distributions at leading twist is presented, in the framework of the Nambu-Jona Lasinio model with Pauli-Villars regularization. The transverse momentum dependence of the obtained distributions is generated solely by the dynamics of the model. Using these results, the so called generalized Boer-Mulders shift is studied and compared with recent lattice data. The obtained agreement is very encouraging, in particular because no additional parameter has been introduced. A more conclusive comparison would require a precise knowledge of the QCD evolution of the transverse momentum dependent parton distributions under scrutiny.

  7. Condensation energy of the Nambu-Jona-Lasinio vacuum and the MIT bag constant

    International Nuclear Information System (INIS)

    Li, S.; Bhalerao, R.S.; Bhaduri, R.K.

    1991-01-01

    In this paper the energy densities of the vacuum in the Wigner and the Goldstone modes of the Nambu- Jona-Lasinio Hamiltonian are calculated. The difference of these two quantities is analogous to the condensation energy of a BCS superconductor, and is used here to estimate the temperature dependence of the MIT bag constant. The formalism of da Providencia et al is generalized to finite temperatures, yielding the same gap equation as the finite- temperature field theory. The thermodynamics of the vacuum in the two phases is studied

  8. Thermodynamics of strongly interacting system from reparametrized Polyakov-Nambu-Jona-Lasinio model

    International Nuclear Information System (INIS)

    Bhattacharyya, Abhijit; Ghosh, Sanjay K.; Maity, Soumitra; Raha, Sibaji; Ray, Rajarshi; Saha, Kinkar; Upadhaya, Sudipa

    2017-01-01

    The Polyakov-Nambu-Jona-Lasinio model has been quite successful in describing various qualitative features of observables for strongly interacting matter, that are measurable in heavy-ion collision experiments. The question still remains on the quantitative uncertainties in the model results. Such an estimation is possible only by contrasting these results with those obtained from rst principles using the lattice QCD framework. Recently a variety of lattice QCD data were reported in the realistic continuum limit. Here we make a first attempt at reparametrizing the model so as to reproduce these lattice data

  9. Regularization dependence on phase diagram in Nambu–Jona-Lasinio model

    International Nuclear Information System (INIS)

    Kohyama, H.; Kimura, D.; Inagaki, T.

    2015-01-01

    We study the regularization dependence on meson properties and the phase diagram of quark matter by using the two flavor Nambu–Jona-Lasinio model. The model also has the parameter dependence in each regularization, so we explicitly give the model parameters for some sets of the input observables, then investigate its effect on the phase diagram. We find that the location or the existence of the critical end point highly depends on the regularization methods and the model parameters. Then we think that regularization and parameters are carefully considered when one investigates the QCD critical end point in the effective model studies

  10. Bosonization of the generalized SU(3) Nambu-Jona-Lasinio model in the 1/N expansion

    International Nuclear Information System (INIS)

    Campos, Francisco Antonio Pena

    1995-01-01

    The present work consists in a 1/N expansion of extended version of the SU(3) Nambu-Jona-Lasinio model in the context of the Functional Integral. The gap equations, meson propagators, triangle diagram, etc, appear quite naturally as different orders in the expansion. The new features of this approach is the inclusion of high order corrections in the 1/N leading orders, which have never included in the previous one. The method also allows for the construction of a chiral Lagrangian of interacting mesons based on the SU(3) NJL model, here obtained for the first time. (author)

  11. Monte Carlo simulations of hadronic fragmentation functions using the Nambu-Jona-Lasinio-jet model

    International Nuclear Information System (INIS)

    Matevosyan, Hrayr H.; Thomas, Anthony W.; Bentz, Wolfgang

    2011-01-01

    The recently developed Nambu-Jona-Lasinio--jet model is used as an effective chiral quark theory to calculate the quark fragmentation functions to pions, kaons, nucleons, and antinucleons. The effects of the vector mesons ρ, K * , and φ on the production of secondary pions and kaons are included. The fragmentation processes to nucleons and antinucleons are described by using the quark-diquark picture, which has been shown to give a reasonable description of quark distribution functions. We incorporate effects of next-to-leading order in the Q 2 evolution, and compare our results with the empirical fragmentation functions.

  12. The stability of nuclear matter in the Nambu-Jona-Lasinio model

    Energy Technology Data Exchange (ETDEWEB)

    Bentz, W. E-mail: bentz@keyaki.cc.u-tokai.ac.jp; Thomas, A.W. E-mail: athomas@physics.adelaide.edu.au

    2001-12-17

    Using the Nambu-Jona-Lasinio model to describe the nucleon as a quark-diquark state, we discuss the stability of nuclear matter in a hybrid model for the ground state at finite nucleon density. It is shown that a simple extension of the model to simulate the effects of confinement leads to a scalar polarizability of the nucleon. This, in turn, leads to a less attractive effective interaction between the nucleons, helping to achieve saturation of the nuclear matter ground state. It is also pointed out that that the same effect naturally leads to a suppression of 'Z-graph' contributions with increasing scalar potential.

  13. Ethical foundation of the sustainable development in kant, habermas and hans jonas

    OpenAIRE

    Camargo, Sérgio Xavier de; Universidade Estadual de Londrina - UEL; Pinheiro, Ana Cláudia Duarte; Universidade Estadual de Londrina - UEL

    2010-01-01

    A possibilidade de desenvolvimento econômico associado à preservação ambiental é questão relevante para as sociedades contemporâneas. O desenvolvimento sustentável fundamenta-se em questões de conteúdo ético que transcendem aspectos legais, econômicos e políticos. É objetivo deste artigo investigar, em Immanuel Kant, Jürgen Habermas e Hans Jonas, as bases éticas justificadoras do desenvolvimento sustentável. Em Kant, o imperativo categórico, a valorização da universalidade das ações, e a comp...

  14. Properties of vector and axial-vector mesons from a generalized Nambu-Jona-Lasinio model

    International Nuclear Information System (INIS)

    Bernard, V.; Meissner, U.G.; Massachusetts Inst. of Tech., Cambridge; Massachusetts Inst. of Tech., Cambridge

    1988-01-01

    We construct a generalized Nambu-Jona-Lasinio lagrangian including scalar, pseudoscalar, vector and axial-vector mesons. We specialize to the two-flavor case. The properties of the structured vacuum as well as meson masses and coupling constants are calculated giving an overall agreement within 20% of the experimental data. We investigate the meson properties at finite density. In contrast to the mass of the scalar σ-meson, which decreases sharply with increasing density, the vector meson masses are almost independent of density. Furthermore, the vector-meson-quark coupling constants are also stable against density changes. We point out that these results imply a softening of the nuclear equation of state at high densities. Furthermore, we discuss the breakdown of the KFSR relation on the quark level as well as other deviations from phenomenological concepts such as universality and vector meson dominance. (orig.)

  15. Shear viscosities from Kubo formalism in a large-Nc Nambu-Jona-Lasinio model

    International Nuclear Information System (INIS)

    Lang, Robert Friedrich

    2015-01-01

    The quark-gluon plasma produced in heavy-ion collisions at RHIC and LHC is a hot and dense state of strongly correlated matter. It behaves like an almost-perfect fluid featuring a small ratio of shear viscosity to entropy density. In this thesis we calculate within a two-flavor Nambu-Jona-Lasinio model the shear viscosity as function of temperature and chemical potential. A new Kubo formula is developed, incorporating the full Dirac structure of the quark spectral function and avoiding commonly used on-shell approximations. Mesonic fluctuations occurring at Fock level provide the dominant dissipative process. The resulting parameter-free ratio is an overall decreasing function of temperature and chemical potential. In combination with hard-thermal-loop results we nd this ratio to feature a minimum slightly above the AdS/CFT benchmark.

  16. Thermo-magnetic effects in quark matter: Nambu-Jona-Lasinio model constrained by lattice QCD

    Energy Technology Data Exchange (ETDEWEB)

    Farias, Ricardo L.S. [Universidade Federal de Santa Maria, Departamento de Fisica, Santa Maria, RS (Brazil); Kent State University, Physics Department, Kent, OH (United States); Timoteo, Varese S. [Universidade Estadual de Campinas (UNICAMP), Grupo de Optica e Modelagem Numerica (GOMNI), Faculdade de Tecnologia, Limeira, SP (Brazil); Avancini, Sidney S.; Pinto, Marcus B. [Universidade Federal de Santa Catarina, Departamento de Fisica, Florianopolis, Santa Catarina (Brazil); Krein, Gastao [Universidade Estadual Paulista, Instituto de Fisica Teorica, Sao Paulo, SP (Brazil)

    2017-05-15

    The phenomenon of inverse magnetic catalysis of chiral symmetry in QCD predicted by lattice simulations can be reproduced within the Nambu-Jona-Lasinio model if the coupling G of the model decreases with the strength B of the magnetic field and temperature T. The thermo-magnetic dependence of G(B, T) is obtained by fitting recent lattice QCD predictions for the chiral transition order parameter. Different thermodynamic quantities of magnetized quark matter evaluated with G(B, T) are compared with the ones obtained at constant coupling, G. The model with G(B, T) predicts a more dramatic chiral transition as the field intensity increases. In addition, the pressure and magnetization always increase with B for a given temperature. Being parametrized by four magnetic-field-dependent coefficients and having a rather simple exponential thermal dependence our accurate ansatz for the coupling constant can be easily implemented to improve typical model applications to magnetized quark matter. (orig.)

  17. Hadronic decays of tau-leptons in the extended Nambu-Jona-Lasinio model

    Energy Technology Data Exchange (ETDEWEB)

    Kostunin, Dmitriy [Karlsruher Institut fuer Technologie (KIT), Karlsruhe (Germany). Inst. fuer Kernphysik (IKP); Volkov, Mikhail; Arbuzov, Andrey [Bogoliubov Laboratory of Theoretical Physics, Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation)

    2013-07-01

    Modern experiments have collected large statistics on tau-lepton decays and electron-positron annihilation into light hadrons. Therefore it is worthwhile to confront the experimental results with the corresponding theoretical predictions. The extended Nambu-Jona-Lasinio model is a good candidate for the theoretical description of these processes. Excited states of mesons in this version of the NJL model are described with the help of polynomial form-factors with minimal number of parameters. We worked out decays and cross-sections with ππ, ππ(1300), ωπ, ηπ, η'π, ηππ, η'ππ final states. Our calculations are in satisfactory agreement with the existing experimental results. Predictions for branching ratios of suppressed decays were obtained and compared with previous theoretical estimates.

  18. Calculating kaon fragmentation functions from the Nambu-Jona-Lasinio jet model

    International Nuclear Information System (INIS)

    Matevosyan, Hrayr H.; Thomas, Anthony W.; Bentz, Wolfgang

    2011-01-01

    The Nambu-Jona-Lasinio (NJL)-jet model provides a sound framework for calculating the fragmentation functions in an effective chiral quark theory, where the momentum and isospin sum rules are satisfied without the introduction of ad hoc parameters. Earlier studies of the pion fragmentation functions using the NJL model within this framework showed qualitative agreement with the empirical parametrizations. Here we extend the NJL-jet model by including the strange quark. The corrections to the pion fragmentation functions and corresponding kaon fragmentation functions are calculated using the elementary quark to quark-meson fragmentation functions from NJL. The results for the kaon fragmentation functions exhibit a qualitative agreement with the empirical parametrizations, while the unfavored strange quark fragmentation to pions is shown to be of the same order of magnitude as the unfavored light quark. The results of these studies are expected to provide important guidance for the analysis of a large variety of semi-inclusive data.

  19. Shear viscosities from Kubo formalism in a large-Nc Nambu-Jona-Lasinio model

    International Nuclear Information System (INIS)

    Lang, Robert; Kaiser, Norbert; Weise, Wolfram

    2015-01-01

    In this work the shear viscosity of strongly interacting matter is calculated within a two-flavor Nambu-Jona-Lasinio model as a function of temperature and chemical potential. The general Kubo formula is applied, incorporating the full Dirac structure of the thermal quark spectral function and avoiding commonly used on-shell approximations. Mesonic fluctuations contributing via Fock diagrams provide the dominant dissipative processes. The resulting ratio η/s (shear viscosity over entropy density) decreases with temperature and chemical potential. Interpolating between our NJL results at low temperatures and hard thermal loop results at high temperatures a minimum slightly above the AdS/CFT benchmark η/s = 1/4τ is obtained. (orig.)

  20. Relation between the Lee-Wick and Nambu-Jona-Lasinio models of chiral symmetry breaking

    International Nuclear Information System (INIS)

    Klevansky, S.P.; Lemmer, R.H.

    1990-01-01

    The connection between the sigma model of Lee and Wick and the Nambu-Jona-Lasinio (NJL) model is discussed. It is shown that the sigma field potential of the linear Lee-Wick model is identical in form with the variation of the vacuum energy of the NJL system with the baryonic scalar density n s . The sigma field is proportional to n s . Furthermore, the coupling constant and mass of this σ field are fully determined by the NJL model version of the Goldberger-Treiman relation. It is shown further that the restoration of chiral symmetry with increasing baryonic density always occurs via a second order transition in the NJL model, while it is necessarily of first order in the associated linear Lee-Wick model. (orig.)

  1. Milliseid mõtteid tekitas konverents "Tsensuur meedias ja kunstis"? / Jonas Valatkevicius, Jevgeni Tsymbal, Mark Soosaar...[jt.] ; interv. Grete Naaber

    Index Scriptorium Estoniae

    2000-01-01

    Küsimusele vastavad Vilniuse kunstikeskuse kuraator Jonas Valatkevicius, Moskva filmirežissöör Jevgeni Tsymbal, Mark Soosaar, Albaania kunstigalerii juhataja Gezim Qendro, BBC ajakirjanik Tiina Tamman

  2. [Responsibility: Towards a fifth principle in blood transfusion's ethics. Applicability and limits of Hans Jonas's responsibility principle].

    Science.gov (United States)

    Nélaton, C

    2016-09-01

    Nowadays, in France, anonymity, gratuity, volunteering, non-profit are recognized as ethical principles in blood transfusion. Can we add responsibility to this list? Can a logo named "Responsiblood" efficiently encourage blood donation? This article explores Hans Jonas's reform of the responsibility concept in order to measure its applicabilities and limits in the field of blood transfusion. Indeed, this concept - rethought by Jonas - seems to be a good encouragement which avoids the pitfalls of the concept of duty and of the idea of payment for blood donation. But can't we also see in this reform a threat to blood transfusion because of technophobia and the heuristics of fear that it involves? Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  3. The ethics of human condition in the age of technological civilization. Back and forth with Heidegger and Jonas.

    Directory of Open Access Journals (Sweden)

    Angela Luzia Miranda

    2009-07-01

    Full Text Available The ethical dimension of the human condition in our times takes increasingly more space in current philosophical discussions. In this context, the ethical principle of responsibility has been widely discussed, particularly by authors who work on the ethical implications of modern technology. In his essay on ethics for the technological age, Hans Jonas proposes to base ethics on a principle of responsibility, taking into account that we live in the age of technological civilization. The present paper explores the origins and sources of Jonas’ principle of responsibility, focusing on the influence of his teacher Martin Heidegger on Jonas’s work. The paper analyses the intrinsic and intriguing relationship between Heidegger’s ontological concept of “care” [Sorge] and the idea or responsibility in Jonas, and it examines further the current discussion on the possibility of an ethical foundation for the techno scientific civilization. Keywords:  Philosophy of technology; Éthics and technology; Ontology; Martin Heidegger; Hans Jonas.

  4. Collective modes of the Nambu--Jona-Lasinio model with an external U(1) gauge field

    International Nuclear Information System (INIS)

    Klevansky, S.P.; Jaenicke, J.; Lemmer, R.H.

    1991-01-01

    The effect of external color fields on the collective modes of the SU L (2)xSU R (2) chiral flavor version of the Nambu--Jona-Lasinio model is studied analytically in a U(1) approximation to the gauge fields. We show that the scalar and pseudoscalar modes respond differently to external chromomagnetic and -electric fields. In the former case, in which chiral asymmetry is enhanced, the modes remain well separated and vary slowly with the field, while in the latter case the scalar mode drops rapidly to become degenerate with the pseudoscalar mode in the chiral limit. In this regime, both modes are weakly coupled to quark matter, and the pseudoscalar pion mode in particular survives as a well-defined excitation as it enters the pair continuum. The Goldberger-Treiman relation, which is shown to hold in the presence of external fields, is responsible for this behavior. Chromoelectric and -magnetic polarizabilities are seen to be equal and opposite with absolute values β σ =2.0α s and β π =0.03α s for the scalar and pseudoscalar modes respectively

  5. Quark matter and quark stars at finite temperature in Nambu-Jona-Lasinio model

    Energy Technology Data Exchange (ETDEWEB)

    Chu, Peng-Cheng; Wang, Bin; Dong, Yu-Min; Jia, Yu-Yue; Wang, Shu-Mei; Ma, Hong-Yang [Qingdao Technological University, School of Science, Qingdao (China); Li, Xiao-Hua [University of South China, School of Nuclear Science and Technology, Hengyang (China); University of South China, Cooperative Innovation Center for Nuclear Fuel Cycle Technology and Equipment, Hengyang (China)

    2017-08-15

    We extend the SU(3) Nambu-Jona-Lasinio (NJL) model to include two types of vector interaction. Using these two types of vector interaction in NJL model, we study the quark symmetry free energy in asymmetric quark matter, the constituent quark mass, the quark fraction, the equation of state (EOS) for β-equilibrium quark matter, the maximum mass of QSs at finite temperature, the maximum mass of proto-quark stars (PQSs) along the star evolution, and the effects of the vector interaction on the QCD phase diagram. We find that comparing zero temperature case, the values of quark matter symmetry free energy get larger with temperature increasing, which will reduce the difference between the fraction of u, d and s quarks and stiffen the EoS for β-equilibrium quark matter. In particular, our results indicate that the maximum masses of the quark stars increase with temperature because of the effects of the quark matter symmetry free energy, and we find that the heating(cooling) process for PQSs will increase (decrease) the maximum mass within NJL model. (orig.)

  6. Color superconductivity in the Nambu-Jona-Lasinio model complemented by a Polyakov loop

    Energy Technology Data Exchange (ETDEWEB)

    Blanquier, Eric

    2017-06-15

    The color superconductivity is studied with the Nambu and Jona-Lasinio (NJL) model. This one is coupled to a Polyakov loop, to form the PNJL model. A μ-dependent Polyakov loop potential is also considered (μPNJL model). An objective is to detail the analytical calculations that lead to the equations to be solved, in all of the treated cases. They are the normal quark (NQ), 2-flavor color-superconducting (2SC) and color-flavor-locked (CFL) phases, in an SU(3){sub f} x SU(3){sub c} description. The calculations are performed according to the temperature T, the chemical potentials μ{sub f} or the densities ρ{sub f}, with or without the isospin symmetry. The relation between the μ{sub f} and ρ{sub f} results is studied. The influence of the color superconductivity and the Polyakov loop on the found data is analyzed. A triple coincidence is observed at low T between the chiral restoration, the deconfinement transition described by the Polyakov loop and the NQ/2SC phase transition. Furthermore, an sSC phase is identified in the ρ{sub q}, ρ{sub s} plane. Possible links between certain of the obtained results and physical systems are pointed out. (orig.)

  7. Symmetry energy and neutron star properties in the saturated Nambu–Jona-Lasinio model

    Directory of Open Access Journals (Sweden)

    Si-Na Wei

    2016-12-01

    Full Text Available In this work, we adopt the Nambu–Jona-Lasinio (NJL model that ensures the nuclear matter saturation properties to study the density dependence of the symmetry energy. With the interactions constrained by the chiral symmetry, the symmetry energy shows novel characters different from those in conventional mean-field models. First, the negative symmetry energy at high densities that is absent in relativistic mean-field (RMF models can be obtained in the RMF approximation by introducing a chiral isovector–vector interaction, although it would be ruled out by the neutron star (NS stability. Second, with the inclusion of the isovector–scalar interaction the symmetry energy exhibits a general softening at high densities even for the large slope parameter of the symmetry energy. The NS properties obtained in the present NJL model can be in accord with the observations. The NS maximum mass obtained with various isovector–scalar couplings and momentum cutoffs is well above the 2M⊙, and the NS radius obtained well meets the limits extracted from recent measurements. In particular, the significant reduction of the canonical NS radius occurs with the moderate decrease of the slope of the symmetry energy.

  8. The tourist gaze 3.0 (John Urry y Jonas Larsen

    Directory of Open Access Journals (Sweden)

    Daniel Carmona Zubiri

    2014-05-01

    Full Text Available Tercera edición del clásico de la Sociología del turismo en habla inglesa The tourist gaze (19901, de John Urry, incorporando esta vez al joven académico danés Jonas Larsen como coautor. Esta nueva edición, además de revisar y actualizar datos y contenido de las dos anteriores, aporta tres capítulos nuevos dedicados al análisis de las representaciones y puestas en escena de los turistas, la fotografía y el mundo virtual, así como a los riesgos de futuro relacionados con el turismo. De esta manera, el volumen se estructura en nueve capítulos, cada uno de los cuales correspondiente a un enfoque analítico distinto sobre el concepto de la «mirada del turista», con sus propias introducciones, apartados y conclusiones, pero sin introducción ni conclusión general o epílogo que vertebre la obra de principio a fin.

  9. The SU(3)-Nambu-Jona-Lasinio soliton in the collective quantization formulation

    International Nuclear Information System (INIS)

    Blotz, A.; Goeke, K.; Diakonov, D.; Petrov, V.; Pobylitsa, P.V.; Park, N.W.

    1992-01-01

    On grounds of a semibosonized Nambu-Jona-Lasinio model, which has SU(3) R circle-times SU(3) L -symmetry in the chiral limit, mass splittings for spin 1/2 and spin 3/2 baryons are studied in the presence of an explicit chiral symmetry breaking strange quark mass. To this aim these strangeness carrying baryons are understood as SU(3)-rotational excitations of an SU(2)-embedded soliton solution. Therefore, within the framework of collective quantization, the fermion determinant with the strange quark mass is expanded up to the second order in the flavor rotation velocity and up to the first order in this quark mass. Besides the strange and non-strange moments of inertia, which have some counterparts within the Skyrme model, some so-called anomalous moments of inertia are obtained. These call be related to the imaginary part of the effective Euclidian action and contain among others the anomalous baryon current. This is shown in a gradient expansion up to the first non-vanishing order. Together with the Σ-commutator these are the solitonic ingredients of the collective hamiltonian, which is then diagonalized by means of strict perturbation theory in the strange quark mass and by the Yabu-Audo method. Both methods yield very good results for the masses of the spin 1/2 and 3/2 baryons. The former one reproduces some interesting mass formulas of Gell-Mann Okubo and Guadagnini and the latter one is able to describe the mass splittings up to a few MeV

  10. Coupled-channel dynamics in the Nambu--Jona-Lasinio model

    International Nuclear Information System (INIS)

    Celenza, L.S.; Pantziris, A.; Shakin, C.M.; Szweda, J.

    1993-01-01

    We study the scalar-isoscalar sector of the Nambu--Jona-Lasinio (NJL) model and extend the model to include a description of the coupling of the quark-antiquark states to the two-pion continuum. The q bar q interaction gives rise to a sigma meson, which takes on a width and energy shift that depends upon the strength of the coupling for q+bar q→π+π. (For weak channel coupling, the resonance is located at the mass of the sigma, m σ congruent 2m q cons , where m q cons is the constituent quark mass of the NJL model.) We consider two models for the q bar q→ππ coupling. In the first model, we find a low-energy resonance, with the resonance energy E R ≤2m q cons . We then see that the values, obtained from the analysis of experimental data, of the scalar-isoscalar phase shift describing ππ scattering δ 0 0 , are not compatible with the existence of a low-mass sigma. In the second model, the resonance is pushed upward into the region of the two-quark continuum, E R >2m q cons . This second model provides an example of a phenomenon where the behavior of the q bar q T matrix is parametrized for q 2 ≤0 by a mass that is smaller than the physical mass that characterizes the pole in the T matrix. The behavior of the second model suggests how the absence of experimental evidence for a low-mass sigma may be reconciled with the importance of such a meson in nuclear structure studies

  11. Bosonization of the generalized SU(3) Nambu-Jona-Lasinio model in the 1/N expansion; Bosonizacao do modelo de Nambu-Jona-Lasinio SU(3) generalizado na expansao 1/N

    Energy Technology Data Exchange (ETDEWEB)

    Campos, Francisco Antonio Pena

    1995-12-31

    The present work consists in a 1/N expansion of extended version of the SU(3) Nambu-Jona-Lasinio model in the context of the Functional Integral. The gap equations, meson propagators, triangle diagram, etc, appear quite naturally as different orders in the expansion. The new features of this approach is the inclusion of high order corrections in the 1/N leading orders, which have never included in the previous one. The method also allows for the construction of a chiral Lagrangian of interacting mesons based on the SU(3) NJL model, here obtained for the first time. (author) 32 refs., 11 figs., 5 tabs.

  12. Renormalization of the Nambu-Jona Lasinio model and spontaneously broken Abelian Gauge model without fundamental scalar fields

    International Nuclear Information System (INIS)

    Snyderman, N.J.

    1976-01-01

    The Schwinger-Dyson equation for the Nambu-Jona Lasinio model is solved systematically subject to the constraint of spontaneously broken chiral symmetry. The solution to this equation generates interactions not explicitly present in the original Lagrangian, and the original 4-fermion interaction is not present in the solution. The theory creates bound-states with respect to which a perturbation theory consistent with the chiral symmetry is set up. The analysis suggests that this theory is renormalizable in the sense that all divergences can be grouped into a few arbitrary parameters. The renormalized propagators of this model are shown to be identical to those of a new solution to the sigma-model in which the bare 4-field coupling lambda 0 is chosen to be twice the π-fermion coupling g 0 . Also considered is spontaneously broken abelian gauge model without fundamental scalar fields by coupling an axial vector gauge field to the N ambu-Jona Lasinio model. It is shown how the Goldstone consequence of spontaneous symmetry breaking is avoided in the radiation gauge, and verify the Guralnik, Hagen, and Kibble theorem that under these conditions the global charge conservation is lost even though there is still local current conservation. This is contrasted with the Lorentz gauge situation. This also demonstrated the way the various noncovariant components of the massive gauge field combine in a gauge invariant scattering amplitude to propagate covariantly as a massive spin-1 particle, and this is compared with the Lorentz gauge calculation. F inally, a new model of interacting massless fermions is introduced, based on the models of Nambu and Jona Lasinio, and the Bjorken, which spontaneously breaks both chiral symmetry and Lorentz invariance. The content of this model is the same as that of the gauge model without fundamental scalar fields, but without fundamental gauge fields as well

  13. Muusikamaailm. Magnus Lindbergi festivali jätk. Jonas Forsell taas ooperijuhiks. Marcello Panni uus ooper. György Kurtagile Sonningi preemia. Peter Gradenwitz lahkunud / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2002-01-01

    Soome helilooja Magnus Lindbergi mitmeid teoseid esitatakse Inglismaal. Rootsi heliloojast Jonas Forsellist sai jaanuaris Kopenhaageni trupi Den Anden Opera kunstiline juht. Firenzes tuli esiettekandele Marcello Panni uus ooper "The Banquet ئ Talking about Love". Helilooja György Kurtag pälvis Taani 2003.a. Leonie Sonningi muusikapreemia. 91aastasena suri muusikateadlane Peter Gradenwitz

  14. Anomalous decay f1(1285 )→π+π-γ in the Nambu-Jona-Lasinio model

    Science.gov (United States)

    Osipov, A. A.; Volkov, M. K.

    2018-04-01

    Using the Nambu-Jona-Lasinio model with the U (2 )×U (2 ) chiral symmetric effective four-quark interactions, we derive the amplitude of the radiative decay f1(1285 )→π+π-γ , find the decay width Γ (f1→π+π-γ )=346 keV and obtain the spectral dipion effective mass distribution. It is shown that in contrast to the majority of theoretical estimates (which consider the a1(1260 ) meson exchange as the dominant one), the most relevant contribution to this process is the ρ0-resonance exchange related with the triangle f1ρ0γ anomaly. The spectral function is obtained to be confronted with the future empirical data.

  15. Chiral symmetry in the strong color-electric field in terms of Nambu-Jona-Lasinio model

    International Nuclear Information System (INIS)

    Suganuma, Hideo

    1990-01-01

    We examine the behavior of chiral symmetry in an external gluon field using Nambu-Jona-Lasinio model, which is an effective theory of QCD. The Dyson equation for the dynamical quark mass in the presence of the external color-electric field is obtained. By solving it in the color flux tube inside mesons, chiral symmetry would be restored in the flux tube of mesons and this result supports Chiral Bag picture for mesons. Next we consider the flux tubes formed in the central region for ultra-relativistic heavy-ion collisions, and find the chiral restoration occurs there, so that the current quark mass seems to be suitable in calculating the q-q-bar pair creation rate by the Schwinger formula in the flux-tube picture. (author)

  16. A renovação da teleologia em Hans Jonas: da biologia filosófica aos fundamentos da ética

    Directory of Open Access Journals (Sweden)

    Wendell Evangelista Soares Lopes

    2010-12-01

    Full Text Available The present paper aims to elucidate the renewal of teleology in the thought of Hans Jonas showing how it takes up two central functions, namely: to think a philosophical biology – or ontology – that more accurately meets the construction of a coming-to-be and psychophysical universe; and to think the ought-to-be of humanity as the telos and absolute value in the evolutionary process of Being. To accomplish our goal, we explain first that what Jonas calls the “riddle of subjectivity” is the basic problem of ontology, and that modern philosophy fails to respond to it, thus requiring a rehabilitation – and renewal – of a teleological conception of being. Then we will show that this renewal of teleology, that can be called “neo-finalism”, defines finalism as intrinsic not only to individual beings, but also to the devenir of the world itself, where man would be the very ultimate realization of a latent possibility within this evolutionary process of the universal substance. Hence would result a principle of ethics which is ultimately grounded neither in the autonomy of the self nor in the needs of community, but in the teleological character of the evolutionary process of nature itself – man as the “final quality”, and thus the absolute value, of such a process. That is to say, for Jonas teleology aims to finally answer what is the good about humanity, who would sign as well as the very foundation of ethics.

  17. Ética e técnica? Dialogando com Marx, Spengler, Jünger, Heidegger e Jonas Ethics and technology? Dialoguing with Marx, Spengler, Jünger, Heidegger and Jonas

    Directory of Open Access Journals (Sweden)

    Franz Josef Brüseke

    2005-12-01

    Full Text Available O século XIX entendeu a técnica como um elemento central do progresso histórico, mudando nas primeiras décadas do século XX essa perspectiva. mas a crítica à técnica formulada entre as duas guerras mundiais nos vieses da crítica à cultura e, de forma emblemática, presente na obra de Oswald Spengler, ainda não coloca a técnica em relação à ética. Neste tempo do interludium bellicum (1918-1939,articula-se uma compreensão da técnica emancipada de qualquer dimensão metafísica e artística, por um lado e, por outro lado, vê-se um recarregamento da técnica com uma promessa salvacionista, utópica ou heróica, não obstante, totalmente absorvida por uma concepção materialista do mundo, concebido enquanto campo de batalha (Ernst Jünger. Martin Heidegger elaborou, no final dos anos trinta e em meados dos anos quarenta, em um movimento de distanciamento intelectual da sua época, as bases de uma filosofia da técnica com grandes repercussões. Um dos seus alunos, Hans Jonas, tenta de forma original, mas não livre de equívocos, apresentar uma ética válida para a civilização tecnológica. Segundo Jonas, a situação do homem e o contexto de qualquer propósito ético estariam hoje fundamentalmente mudados; uma ética tradicional não estaria mais à sua altura. A técnica moderna introduziu novos objetos e processos, com conseqüências até então desconhecidas, na sociedade humana, de uma maneira que exigiria uma adaptação da ética (e conseqüentemente da ação humana aos desafios tecnológicos. A "ética do próximo" teria validez, ainda, nas "proximidades"; o futuro da humanidade no seu habitat planetário exigiria, todavia, uma "ética da responsabilidade".The nineteenth century took technology as a central element of historical progress, but the perspective occurred to change during the first decades of the twentieth century. The criticism of technology formulated between the two world wars period in the stream of

  18. Enforced neutrality and color-flavor unlocking in the three-flavor Polyakov-loop Nambu-Jona-Lasinio model

    International Nuclear Information System (INIS)

    Abuki, H.; Ciminale, M.; Nardulli, G.; Ruggieri, M.; Gatto, R.

    2008-01-01

    We study how the charge neutrality affects the phase structure of the three-flavor Polyakov-loop Nambu-Jona-Lasinio (PNJL) model. We point out that, within the conventional PNJL model at finite density, the color neutrality is missing because the Wilson line serves as an external colored field coupled to dynamical quarks. In this paper we heuristically assume that the model may still be applicable. To get color neutrality, one has then to allow nonvanishing color chemical potentials. We study how the quark matter phase diagram in (T,m s 2 /μ)-plane is affected by imposing neutrality and by including the Polyakov-loop dynamics. Although these two effects are correlated in a nonlinear way, the impact of the Polyakov loop turns out to be significant in the T direction, while imposing neutrality brings a remarkable effect in the m s 2 /μ direction. In particular, we find a novel unlocking transition, when the temperature is increased, even in the chiral SU(3) limit. We clarify how and why this is possible once the dynamics of the colored Polyakov loop is taken into account. Also we succeed in giving an analytic expression for T c for the transition from two-flavor pairing (2SC) to unpaired quark matter in the presence of the Polyakov loop.

  19. The Polyakov, Nambu and Jona-Lasinio model and its applications to describe the sub-nuclear particles

    International Nuclear Information System (INIS)

    Blanquier, E.

    2013-01-01

    To study the high energy nuclear physics and the associated phenomenon, as the quark-gluon plasma / hadronic matter phase transition, the Nambu and Jona-Lasinio model (NJL) appears as an interesting alternative to the Quantum Chromodynamics, not solvable at the considered energies. Indeed, the NJL model allows the description of quarks physics, at finite temperatures and densities. Furthermore, in order to try to correct a limitation of the NJL model, i.e. the absence of confinement, it was proposed a coupling of the quarks/antiquarks to a Polyakov loop, forming the PNJL model. The objective of this thesis is to see the possibilities offered by the NJL and PNJL models, to describe relevant sub-nuclear particles (quarks, mesons, diquarks and baryons), to study their interactions, and to proceed to a dynamical study involving these particles. After a recall of the useful tools, we modeled the u, d, s effective quarks and the mesons. Then, we described the baryons as quarks-diquarks bound states. A part of the work concerned the calculations of the cross-sections associated to the possible reactions implying these particles. Then, we incorporated these results in a computer code, in order to study the cooling of a quarks/antiquarks plasma and its hadronization. In this study, each particle evolves in a system in which the temperature and the densities are local parameters. We have two types of interactions: one due to the collisions, and the other is a remote interaction, notably between quarks. Finally, we studied the properties of our approach: qualities, limitations, and possible evolutions. (author)

  20. Inertial mass of the chiral quark-loop soliton in the Nambu and Jona-Lasinio model at finite temperature and density

    International Nuclear Information System (INIS)

    Schleif, M.; Wuensch, R.

    1996-04-01

    We consider the mass of the one-loop hedgehog soliton of the bosonized SU(2) Nambu and Jona-Lasinio model embedded in hot nuclear matter minimiced by a gas of constituent quarks. We prove that the proper-time regularized and self-consistently determined soliton in a heat bath obeys Poincare's invariance up order V 2 . At finite temperature and chemical potential, we show that the inertial mass obtained in the perturbative pushing approach coincides with the total internal energy of the soliton. (orig.)

  1. Extension of the Nambu-Jona-Lasinio model predictions at high temperatures and strong external magnetic field

    International Nuclear Information System (INIS)

    Gomes, Karina P.; Farias, R.L.S.; Pinto, M.B.; Krein, G.

    2013-01-01

    Full text: Recently much attention is dedicated to understand the effects of an external magnetic field on the QCD phase diagram. Actually there is a contradiction in the literature: while effective models of QCD like the Nambu-Jona- Lasinio model (NJL) and linear sigma model predict an increase of the critical temperature of chiral symmetry restoration a function of the magnetic field, recent lattice results shows the opposite behavior. The NJL model is nonrenormalizable; then the high momentum part of the model has to be regularized in a phenomenological way. The common practice is to regularize the divergent loop amplitudes with a three-dimensional momentum cutoff, which also sets the energy-momentum scale for the validity of the model. That is, the model cannot be used for studying phenomena involving momenta running in loops larger than the cutoff. In particular, the model cannot be used to study quark matter at high densities. One of the symptoms of this problem is the prediction of vanishing superconducting gaps at high baryon densities, a feature of the model that is solely caused by the use of a regularizing momentum cutoff of the divergent vacuum and also in finite loop integrals. In a renormalizable theory all the dependence on the cutoff can be removed in favor of running physical parameters, like the coupling constants of QED and QCD. The running is given by the renormalization group equations of the theory and is controlled by an energy scale that is adjusted to the scale of the experimental conditions under consideration. In a recent publication, Casalbuoni et al. have introduced the concept of a running coupling constant for the NJL model to extend the applicability of the model to high density. Their arguments are based on making the cutoff density dependent, using an analogy with the natural cutoff of the Debye frequency of phonon oscillations in an ordinary solid. In the present work we follow such an approach introducing a magnetic field

  2. (via/vili) in khwisero, western kenya

    African Journals Online (AJOL)

    2013-10-10

    Oct 10, 2013 ... KHWISERO, WESTERN KENYA: LESSON FROM THE FIELD AFFECTING POLICY AND PRACTICE. S. K. Ngichabe ... In SSA, cervical cancer affects mostly women in .... inaccessible to the lower socio-economic population.

  3. A responsabilidade como princípio ético em H. Jonas e E. Levinas: uma aproximação

    Directory of Open Access Journals (Sweden)

    Kuiava, Evaldo Antônio

    2006-01-01

    Full Text Available A responsabilidade enquanto princípio ético, embora seja evocada pelos filósofos clássicos, desde a antigüidade ao existencialismo, assume novas perspectivas a partir do pensamento de Hans Jonas e Levinas. Ambos a colocam como centro da ética. Com Jonas a responsabilidade não é mais centrada no passado e no presente. A sua preocupação é com o futuro da humanidade, com as gerações futuras e com a sobrevivência das mesmas. Diferente de Platão, Jonas não está preocupado com a eternidade, mas com o tempo vindouro, compatível com a era da ciência e da tecnologia, cuja responsabilidade passa a ser o alicerce, o princípio orientador para as decisões que possam interferir nas diferentes formas de vida. Levinas, por sua vez, também se afasta da tradição filosófica na medida que não aceita mais a tese de que a responsabilidade é decorrente da liberdade. A responsabilidade não nasce de uma boa vontade, de um sujeito autônomo que quer livremente se comprometer com o outro ser. Ela nasce como resposta a um chamado. A responsabilidade é o fundamento primeiro e essencial da estrutura ética, a qual não aparece como suplemento de uma base existencial prévia. Aquém do ser se encontra uma subjetividade capaz de escutar a voz, sem palavras de um dizer original, e aponta para uma outra dimensão do eu. Prévio ao ato de consciência, anterior ao sujeito intencional, o eu já responde a um chamado. A responsabilidade pelo outro ser precede a representação conceitual ou a mediação de um mandamento ético. Ela é obediência a uma vocação, a uma eleição pelo bem além do ser. A responsabilidade determina a liberdade do eu, pois esta não consegue mais se justificar por ela mesma

  4. Anders Jonas Ångström and the foundation of spectroscopy - Commemorative article on the second centenary of his birth

    Science.gov (United States)

    Reif-Acherman, Simón

    2014-12-01

    The Swedish astronomer Anders Jonas Ångström, born two centuries ago and professor of physics at Uppsala University, was one of the founders of optical spectroscopy. By using diffraction gratings out of glass plates with fine scorings across the face, he was able to observe the spectrum of the Sun, announcing in 1862 that he had discovered the lines of hydrogen in the solar spectrum. His most important work, ;Recherches sur la Spectre Solaire;, including an atlas of close to a thousand spectral lines, became the standard of spectroscopy for at least a quarter of a century. This article deals with his life as well as his main contributions to the development of several areas of physical science, stressing his pioneer activities in spectroscopy.

  5. Anders Jonas Ångström and the foundation of spectroscopy — Commemorative article on the second centenary of his birth

    Energy Technology Data Exchange (ETDEWEB)

    Reif-Acherman, Simón, E-mail: simon.reif@correounivalle.edu.co

    2014-12-01

    The Swedish astronomer Anders Jonas Ångström, born two centuries ago and professor of physics at Uppsala University, was one of the founders of optical spectroscopy. By using diffraction gratings out of glass plates with fine scorings across the face, he was able to observe the spectrum of the Sun, announcing in 1862 that he had discovered the lines of hydrogen in the solar spectrum. His most important work, “Recherches sur la Spectre Solaire”, including an atlas of close to a thousand spectral lines, became the standard of spectroscopy for at least a quarter of a century. This article deals with his life as well as his main contributions to the development of several areas of physical science, stressing his pioneer activities in spectroscopy. - Highlights: • Ångström's work on solar spectroscopy highlights his relevant role in the evolution of this discipline. • Ångström's contributions to different scientific disciplines in physics are detailed. • Ångström's work was pioneer in the determination of precise lines' wave-lengths for some chemical substances. • Ångström's and Kirchhoff's achievements are complementary in the evolution of concepts related with light absorption. • Using of appropriate instruments were decisive for Ångström's success in spectral studies.

  6. Abnormal number of Nambu-Goldstone bosons in the color-asymmetric dense color superconducting phase of a Nambu-Jona-Lasinio-type model

    International Nuclear Information System (INIS)

    Blaschke, D.; Ebert, D.; Klimenko, K.G.; Volkov, M.K.; Yudichev, V.L.

    2004-01-01

    We consider an extended Nambu-Jona-Lasinio model including both (qq-bar) and (qq) interactions with two light-quark flavors in the presence of a single (quark density) chemical potential. In the color superconducting phase of the quark matter the color SU c (3) symmetry is spontaneously broken down to SU c (2). If the usual counting of Goldstone bosons would apply, five Nambu-Goldstone (NG) bosons corresponding to the five broken color generators should appear in the mass spectrum. Unlike that expectation, we find only three gapless diquark excitations of quark matter. One of them is an SU c (2) singlet; the remaining two form an SU c (2) (anti)doublet and have a quadratic dispersion law in the small momentum limit. These results are in agreement with the Nielsen-Chadha theorem, according to which NG bosons in Lorentz-noninvariant systems, having a quadratic dispersion law, must be counted differently. The origin of the abnormal number of NG bosons is shown to be related to a nonvanishing expectation value of the color charge operator Q 8 reflecting the lack of color neutrality of the ground state. Finally, by requiring color neutrality, two massive diquarks are argued to become massless, resulting in a normal number of five NG bosons with the usual linear dispersion laws

  7. Properties of quarks and mesons in the framework of the Nambu and Jona-Lasinio model (NJL model) for finite temperature and density

    International Nuclear Information System (INIS)

    Nebauer, R.

    2000-01-01

    This thesis presents a detailed overview of the thermodynamical properties of the model of Nambu and Jona-Lasinio. In fact, this model can be interpreted as a low energy approximation of QCD. The NJL model has the advantage to be solvable at finite temperature and density. Comparison with QCD lattice calculations show that the NJL model reproduces correctly the feature of chiral symmetry breaking and restoration. We present the chiral phase diagram of the NJL model for three flavors and study the influence of the parameters on the order of the phase transition. The properties of the mesons in a hot and dense medium are another topic of this thesis. We discuss the behaviour of the chiral partners and the influence of the symmetries. A point of special interest are the masses of the kaons in a dense medium. We compare the masses of the kaons with other models like RMF and ChPT. The last part of the thesis is devoted to the low temperature - high density region of the QCD phase diagram. In this region, the formation of a diquark condensate and a superconducting phase are expected. We discuss the structure of the diquark condensate and present the results of the numerical calculations at finite temperature and density. (author)

  8. Sensitivity of predictions in an effective model: Application to the chiral critical end point position in the Nambu-Jona-Lasinio model

    International Nuclear Information System (INIS)

    Biguet, Alexandre; Hansen, Hubert; Brugiere, Timothee; Costa, Pedro; Borgnat, Pierre

    2015-01-01

    The measurement of the position of the chiral critical end point (CEP) in the QCD phase diagram is under debate. While it is possible to predict its position by using effective models specifically built to reproduce some of the features of the underlying theory (QCD), the quality of the predictions (e.g., the CEP position) obtained by such effective models, depends on whether solving the model equations constitute a well- or ill-posed inverse problem. Considering these predictions as being inverse problems provides tools to evaluate if the problem is ill-conditioned, meaning that infinitesimal variations of the inputs of the model can cause comparatively large variations of the predictions. If it is ill-conditioned, it has major consequences because of finite variations that could come from experimental and/or theoretical errors. In the following, we shall apply such a reasoning on the predictions of a particular Nambu-Jona-Lasinio model within the mean field + ring approximations, with special attention to the prediction of the chiral CEP position in the (T-μ) plane. We find that the problem is ill-conditioned (i.e. very sensitive to input variations) for the T-coordinate of the CEP, whereas, it is well-posed for the μ-coordinate of the CEP. As a consequence, when the chiral condensate varies in a 10MeV range, μ CEP varies far less. As an illustration to understand how problematic this could be, we show that the main consequence when taking into account finite variation of the inputs, is that the existence of the CEP itself cannot be predicted anymore: for a deviation as low as 0.6% with respect to vacuum phenomenology (well within the estimation of the first correction to the ring approximation) the CEP may or may not exist. (orig.)

  9. Sensitivity of predictions in an effective model: Application to the chiral critical end point position in the Nambu-Jona-Lasinio model

    Energy Technology Data Exchange (ETDEWEB)

    Biguet, Alexandre; Hansen, Hubert; Brugiere, Timothee [Universite Claude Bernard de Lyon, Institut de Physique Nucleaire de Lyon, CNRS/IN2P3, Villeurbanne Cedex (France); Costa, Pedro [Universidade de Coimbra, Centro de Fisica Computacional, Departamento de Fisica, Coimbra (Portugal); Borgnat, Pierre [CNRS, l' Ecole normale superieure de Lyon, Laboratoire de Physique, Lyon Cedex 07 (France)

    2015-09-15

    The measurement of the position of the chiral critical end point (CEP) in the QCD phase diagram is under debate. While it is possible to predict its position by using effective models specifically built to reproduce some of the features of the underlying theory (QCD), the quality of the predictions (e.g., the CEP position) obtained by such effective models, depends on whether solving the model equations constitute a well- or ill-posed inverse problem. Considering these predictions as being inverse problems provides tools to evaluate if the problem is ill-conditioned, meaning that infinitesimal variations of the inputs of the model can cause comparatively large variations of the predictions. If it is ill-conditioned, it has major consequences because of finite variations that could come from experimental and/or theoretical errors. In the following, we shall apply such a reasoning on the predictions of a particular Nambu-Jona-Lasinio model within the mean field + ring approximations, with special attention to the prediction of the chiral CEP position in the (T-μ) plane. We find that the problem is ill-conditioned (i.e. very sensitive to input variations) for the T-coordinate of the CEP, whereas, it is well-posed for the μ-coordinate of the CEP. As a consequence, when the chiral condensate varies in a 10MeV range, μ {sub CEP} varies far less. As an illustration to understand how problematic this could be, we show that the main consequence when taking into account finite variation of the inputs, is that the existence of the CEP itself cannot be predicted anymore: for a deviation as low as 0.6% with respect to vacuum phenomenology (well within the estimation of the first correction to the ring approximation) the CEP may or may not exist. (orig.)

  10. Ni ética ambiental, ni valores. La reivindicación de Hans Jonas para la ética ambiental hecha por Eric Pommier, considerada desde la crítica de Heidegger al concepto de valor

    Directory of Open Access Journals (Sweden)

    Richard Ayala-Ardila

    2017-01-01

    Full Text Available En este trabajo se cuestiona tanto a la ética ambiental como a la filosofía ambiental desde la crítica hecha por Martin Heidegger al concepto de valor; tal cuestionamiento es precedido por una presentación de las consideraciones de Eric Pommier sobre la ética ambiental, lo cual implica tratar su apreciación de la filosofía ambiental norteamericana (Leopold, Rolston III y Callicot, su lectura de la obra de Hans Jonas y su reivindicación de las ideas de este autor para la ética o para la filosofía ambiental. Se mostrará que los problemas fundamentales de la ética ambiental consisten en encontrar una manera de demostrar el valor intrínseco de la naturaleza y en lograr este objetivo sin hacer concesión alguna al dualismo ontológico.

  11. Ventilator induced lung injury (VILI) in acute respiratory distress ...

    African Journals Online (AJOL)

    The lung protective ventilation strategy- Low tidal volume ventilation has shown some reduction in mortality in patients with ARDS but mortality is still high in patient with severe ARDS secondary to Pneumocystis jiroveci pneumonia (PJP) despite of lung protective ventilation strategy. In patients with Severe ARDS due to PJP ...

  12. Properties of quarks and mesons in the framework of the Nambu and Jona-Lasinio model (NJL model) for finite temperature and density; Proprietes des quarks et mesons a temperature et densite finies dans le cadre du modele NJL

    Energy Technology Data Exchange (ETDEWEB)

    Nebauer, R

    2000-09-29

    This thesis presents a detailed overview of the thermodynamical properties of the model of Nambu and Jona-Lasinio. In fact, this model can be interpreted as a low energy approximation of QCD. The NJL model has the advantage to be solvable at finite temperature and density. Comparison with QCD lattice calculations show that the NJL model reproduces correctly the feature of chiral symmetry breaking and restoration. We present the chiral phase diagram of the NJL model for three flavors and study the influence of the parameters on the order of the phase transition. The properties of the mesons in a hot and dense medium are another topic of this thesis. We discuss the behaviour of the chiral partners and the influence of the symmetries. A point of special interest are the masses of the kaons in a dense medium. We compare the masses of the kaons with other models like RMF and ChPT. The last part of the thesis is devoted to the low temperature - high density region of the QCD phase diagram. In this region, the formation of a diquark condensate and a superconducting phase are expected. We discuss the structure of the diquark condensate and present the results of the numerical calculations at finite temperature and density. (author)

  13. Algumas aproximações entre a Ética do Futuro, de Hans Jonas, e o modelo aristotélico para a Ecoética proposto por Pierre Aubenque/Some approximations between Hans Jonas’ ethics of future and the Pierre Aubenque’s proposal for the aristotelian model to the

    OpenAIRE

    Moura, Sarah; Universidade Federal do Rio de Janeiro

    2015-01-01

    Este trabalho pretende evidenciar aproximações entre propostas éticas de Hans Jonas (Alemanha,1903-EUA,1993) e Pierre Aubenque (França, 1929-). Ambos corroboram a tese que defende a prudência como a virtude da ética que se faz necessária nesses tempos de hegemonia tecnocientífica e economia baseada no consumo. Estes eminentes pensadores do século XX também apresentam críticas semelhantes em relação ao pensamento moderno, à ética kantiana e à supremacia da razão calculante. Ambos se inspiraram...

  14. Arme Jona tussen teks en werklikheid

    Directory of Open Access Journals (Sweden)

    P. J. Nel

    1999-08-01

    Full Text Available Poor Jonah between text and reality The paper provides argumentation in favour of an alternative reading of the text of Jonah in order to free it from any obligation in terms of which it should be read as a historical discourse, without denying its legitimate truth claim(s. In actual fact, an argument is construed here which subsumes that the text�s authenticity can only be maintained when its peculiar mode (narrative of communication is honored. An exposition is given of the central plot developed throughout the sequence of the episodes, and of the metaphoric contribution of the poem of chapter two. To free the character Jonah from the unduly negative receptions of traditional exegesis, the author seeks to displace him from the historical world and reintroduce him within the confines of the diegetic world of story.

  15. Emergency percutaneous tracheostomy | Jonas | South African ...

    African Journals Online (AJOL)

    No Abstract South African Journal of Surgery Vol. 45 (3) 2007: pp. 106-107. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL ...

  16. Emergency percutaneous tracheostomy | Jonas | South African ...

    African Journals Online (AJOL)

    South African Journal of Surgery. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 45, No 3 (2007) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register · Download this PDF file. The PDF file you selected should ...

  17. 2228-IJBCS-Article-Jonas Koala

    African Journals Online (AJOL)

    hp

    Keywords: Disturbances, soil water properties, Burkina Faso, soil ... and energy of rain reaching the ground. Water ... a.s.l in Burkina Faso, West Africa (Figure 1). ...... Estimates Due to Sample Volume and. Shape. Vadose Zo. J., 4: 1183–1190.

  18. Tensor Excitations in Nambu - Jona-Lasinio Model

    CERN Document Server

    Chizhov, M V

    1996-01-01

    It is shown that in the one-flavour NJL model the vector and axial-vector quasiparticles described by the antisymmetric tensor field are generated. These excitations have tensor interactions with quarks in contrast to usual vector ones. Phenomenological applications are discussed.

  19. Magnetic foreign body on the nasal septum | Jonas | South African ...

    African Journals Online (AJOL)

    No Abstract South African Journal of Surgery Vol. 45 (4) 2007: pp. 151-151. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL ...

  20. Industri Pariwisata Ditinjau dari Etika Tanggung Jawab Hans Jonas

    Directory of Open Access Journals (Sweden)

    Vitria Ariani

    2013-10-01

    Full Text Available Ecology is a system of balance between the elements of nature and man. Man as an animal that thinks has the concept of moral and responsibility toward himself, man with another man, and man with nature surroundings. Harmony or disharmony realization of ecological values is a concept of how to realize the appreciation of human values and the ideal of human interaction with the nature. Social norms, ethical values and social systems, the communication between people with other people and the world must take place in a positive, sustainable, and harmonious way. Technology makes man exploit nature for his own benefit. Advances in technology, on one hand, make human life easier. However, on the other hand, the progress has made natural destruction. Tourism is an activity that utilizes natural, social, and cultural resources that have broad impact on the development of tourism-related activities with the technology and activities in it. Tourism activities also have broad impact as as a multi-sectoral, multi-dimensional, and an integrated tourism industry to one and another. Ethics that puts the responsibility for Tourism Sustainability is the answers to minimize ecological damage to nature caused by the Tourism Industry. 

  1. Responsibility to Nature? Hans Jonas and Environmental Ethics

    Directory of Open Access Journals (Sweden)

    Peter Wolsing

    2013-11-01

    Full Text Available This paper presents the philosopher Hans Jonas’s idea of an environmental ethics. Through an outline of the development of man’s relation to nature from Greek antiquity to the present it is argued that science and technology in modernity favour a relation of exploitation which is partly the cause of fatal climate changes. Through Jonas’s philosophical notion of an ontology of man as an alternative to classical dualism and by means of a turn to an ontological interpretation of Kant’s categorical imperative, it is argued that mankind has a responsibility to both coming generations and to the biosphere as a whole. Not only does this ontological shift from philosophy of mind to an ontology of man transcend dualism in philosophy, it throws a new critical light on the technological development and suggests a new way of considering man’s place in the cosmos.

  2. Jonas Gwangwa: Musician And Cultural Activist | Szymczak | South ...

    African Journals Online (AJOL)

    Open Access DOWNLOAD FULL TEXT Subscription or ... opportunity of an internationally televised interview,1 on the occasion of the Grammy awards in the United States, to declare on behalf of the leadership of a then exiled African National ...

  3. Jonas U. Ezema and Adizetu A. Ali STRATEGIES FOR ENHANCING ...

    African Journals Online (AJOL)

    learning, mobile schools, information repackaging, translation services, book mobile, use of audio visuals .... Audio-visual resources, commonly referred to as instructional materials form a ... appreciation of reading communication and literate.

  4. Relvis lapsi otsinud reporteri töö vili üllatas tema abilisi / Evelyn Kaldoja, Eva-Lotta Kivi

    Index Scriptorium Estoniae

    Kaldoja, Evelyn, 1980-

    2017-01-01

    Itaalia fotoajakirjanik Tomaso Clavarino külastas nelja nädala vältel Baltimaade vabatahtlikke kaitseorganisatsioone ja nende korraldatud õppusi ning avaldas ajalehes De Correspondent fotoreportaaži Baltimaades patrullivatest relvastatud lastest. Fotoajakirjanik Tomaso Clavarino ja De Correspondenti peatoimetaja asetäitja Maurits Martijni kommentaarid

  5. Gluon condensation and modelling of quark confinement in QCD-motivated Nambu-Jona-Lasinio model

    International Nuclear Information System (INIS)

    Bel'kov, A.A.; Ebert, D.; Emel'yanenko, A.V.

    1992-01-01

    The possibility of modelling of a quark propagator without poles realizing quark confinement is considered on the basis of a nonperturbative gluon propagator including gluon condensation and a dynamical gluon mass. The property of spontaneous chiral symmetry breaking is retained providing us with a reasonable pattern of low-lying meson properties. 2 figs.; 1 tab

  6. Nick Jonas on Type 1 Diabetes | NIH MedlinePlus the Magazine

    Science.gov (United States)

    Skip to main content NIH MedlinePlus the Magazine NIH MedlinePlus Salud Download the Current Issue PDF [1.9 mb] Trusted Health Information from the National Institutes of Health Home Current Issue ...

  7. Some aspects of pion physics in the Nambu- and Jona-Lasinio model and chiral Lagrangians

    International Nuclear Information System (INIS)

    Tegen, R.

    1994-03-01

    I discuss here to what extent the original two-flavour NJL model (which has a minimal number of adjustable parameters) reproduces pion observables. In particular, the sensitivity of the recently calculated electromagnetic mass shift to these NJL parameters is pointed out and a new way to fix them is suggested. A new set of O(1/N c ) diagrams, which are the first meson loop corrections to the RPA, is presented and its effect on the pionic Goldstone mode, its electromagnetic form factor, weak decay constant, and on the constituent quark mass m is discusseed. The relation of these NJL model results to some other chiral Lagrangians is pointed out, where ever possible. The here presented higher order diagrams indicate how one could systematically generate the next-order diagrams. It is, however, questionable whether the simplistic but mathematically manageable contact interaction of the NJL model should be maintained also in these higher order diagrams. (orig.)

  8. Aspects of the Color Flavor Locking phase of QCD in the Nambu-Jona Lasinio approximation

    CERN Document Server

    Casalbuoni, Roberto; Nardulli, Giuseppe; Ruggieri, Marco

    2003-01-01

    We study two aspects of the CFL phase of QCD in the NJL approximation. The first one is the issue of the dependence on \\mu of the ultraviolet cutoff in the gap equation, which is solved allowing a running coupling constant. The second one is the dependence of the gap on the strange quark mass; using the high density effective theory we perform an expansion in the parameter (m_s/\\mu)^2 after checking that its numerical validity is very good already at first order.

  9. QCD-motivated Nambu-Jona-Lasinio model with quark and gluon condensates

    International Nuclear Information System (INIS)

    Ebert, D.; Volkov, M.K.

    1991-01-01

    We present a systematic study of the role of the nonperturbative gluon condensate arising in a QCD-motivated NJL model. The effects of the gluon condensate on induced meson couplings, the pion decay constant, quark condensate and mass formulae are investigated. An interesting result is the change of the scale Λ of chiral symmetry breaking and of the universal four-quark coupling κ. (orig.)

  10. Time and crime: which cold-case investigations should be reheated? / Jonathan A. Hughes, Monique Jonas

    Index Scriptorium Estoniae

    Hughes, Jonathan A.

    2015-01-01

    Kriminaalmenetluse eesmärkidest ja tõendamisest; ideest (taas)uurida ajaloolisi, avalikkuse jätkuva huvi all olevaid kuritegusid (nt Rappija Jackiga seonduv) praegusaegsete tehnoloogiliste vahenditega

  11. The quark and gluon condensates in the Nambu-Jona-Lasinio model

    International Nuclear Information System (INIS)

    Ebert, D.; Volkov, M.K.

    1991-10-01

    Systematic study of the role of the nonperturbative gluon condensate arising in a QCD motivated NJL model is presented. The effects of the gluon condensate on meson coupling constants, the pion decay constant, quark condensate and mass formulae are investigated. An interesting result is the decrease of the scale Λ of chiral symmetry breaking. (author). 21 refs

  12. Jonas Savimbi and UNITA's Struggle for Independence. An Application of Mao's Theory of Warfare?

    National Research Council Canada - National Science Library

    Nesbitt, Wanda L

    1997-01-01

    .... Using the key elements of Mao's theory, this paper will examine Savimbi's application of that theory and attempt to address the question of whether UNITA's failure to achieve control in Angola...

  13. On the stability of matter in the Nambu-Jona-Lasinio (NJL) model

    International Nuclear Information System (INIS)

    Tran Huu Phat; Nguyen Tuan Anh; Le Viet Hoa

    2003-01-01

    The matter stability in the NJL model at zero temperature and finite density is reconsidered within the framework of the Cornwall-Jackiw-Tomboulis (CJT) effective action for composite operators. The numerical calculation in the Hartree-Fock (HF) approximation pointed out that for suitably chosen values of the model parameters the thermodynamical potential has a minimum at density k F 0 = 2.3 fm -1 , in the mean while, there is no such minimum in the energy per nucleon and consequently no stable matter. (author)

  14. "Jonas, derefter Katrine og Sebastian": En enkel metode til at lære alle de studerendes navne

    DEFF Research Database (Denmark)

    Jørgensen, Anker Helms

    2012-01-01

    Denne artikel præsenterer en enkel, systematisk metode til at lære alle de studerendes navne i universitetsundervisning. Metoden er ret effektiv: I sidste semester lærte jeg 30 studerendes navne på 1.5 time; det svarer til 3 minutter pr. studerende og 6 minutter pr. uge. Min erfaring viser, at de...

  15. "Jonas, derefter Katrine og Sebastian": En enkel metode til at lære alle de studerendes navne

    DEFF Research Database (Denmark)

    Jørgensen, Anker Helms

    2013-01-01

    Denne artikel præsenterer en enkel, systematisk metode til at lære alle de studerendes navne i universitetsundervisning. Metoden er ret effektiv: I sidste semester lærte jeg 30 studerendes navne på 1.5 time; det svarer til 3 minutter pr. studerende og 6 minutter pr. uge. En empirisk undersøgelse ...

  16. Interplay Between Quark-Antiquark and Diquark Condensates in Vacuum in a Two-Flavor Nambu-Jona-Lasinio Model

    Institute of Scientific and Technical Information of China (English)

    ZHOU Bang-Rong

    2007-01-01

    By means of a relativistic effective potential, we analytically research competition between the quarkLasinio (NJL) model and obtain the Gs-Hs phase diagram, where Gs and Hs are the respective four-fermion coupling constants in scalar quark-antiquark channel and scalar color anti-triplet diquark channel. The results show that, in the that there is no diquark condensates in the vacuum of QCD, will also impose a real restriction to any given two-flavor NJL model which is intended to simulate QCD, i.e. in such model the resulting snallest ratio Gs/Hs after the Fierz transformations in the Hartree approximation must be larger than 2/3. A few phenomenological QCD-like NJL models are checked and analyzed.

  17. Jona se “opstanding uit die dood”: Perspektiewe op die “opstandings-geloof” vanuit die Ou Testament Dirk

    Directory of Open Access Journals (Sweden)

    Dirk J. Human

    2004-10-01

    The Jonah novelette tends to be one of the First Testament’s primary witnesses on the resurrection faith. This faith portrays the omnipotent power of God over all other threatening powers of death and chaos, be they human or divine. Only God can raise the dead from death. Jonah’s resurrection from death illustrates how Yahweh alone is responsible for this endeavour. This article focuses on Jonah’s prayer (2:3-10. It argues that the reader is persuaded to see Jonah’s flight from Yahweh and his commission ultimately leading to his ending up behind the bars of death (2:7b. Embedded in fictitious and mythological descriptions is Yahweh who delivered Jonah from the pit of death, namely Sheol (2:7c. Resurrection faith narratives in the Second Testament confirm these perspectives in the First Testament.

  18. Analysis of the assimilation of SAPARD support programme in Lithuania / Vida Čiulevičiene, Jonas Čiulevičius, Rolandas Kripaitis

    Index Scriptorium Estoniae

    Čiulevičiene, Vida

    2003-01-01

    Analüüsist selgus, et arvuliselt on kõige enam toetuse taotlusi esitatud põllumajandustootmise investeeringute tegemiseks, kuid rahalises väljenduses on suurim saaduste töötlemise ja turustamise valdkonna taotluste osakaal. Tabelid

  19. Characterisation of 12 microsatellite loci in the Vietnamese commercial clam Lutraria rhynchaena Jonas 1844 (Heterodonta: Bivalvia: Mactridae) through next-generation sequencing.

    Science.gov (United States)

    Thai, Binh Thanh; Tan, Mun Hua; Lee, Yin Peng; Gan, Han Ming; Tran, Trang Thi; Austin, Christopher M

    2016-05-01

    The marine clam Lutraria rhynchaena is gaining popularity as an aquaculture species in Asia. Lutraria populations are present in the wild throughout Vietnam and several stocks have been established and translocated for breeding and aquaculture grow-out purposes. In this study, we demonstrate the feasibility of utilising Illumina next-generation sequencing technology to streamline the identification and genotyping of microsatellite loci from this clam species. Based on an initial partial genome scan, 48 microsatellite markers with similar melting temperatures were identified and characterised. The 12 most suitable polymorphic loci were then genotyped using 51 individuals from a population in Quang Ninh Province, North Vietnam. Genetic variation was low (mean number of alleles per locus = 2.6; mean expected heterozygosity = 0.41). Two loci showed significant deviation from Hardy-Weinberg equilibrium (HWE) and the presence of null alleles, but there was no evidence of linkage disequilibrium among loci. Three additional populations were screened (n = 7-36) to test the geographic utility of the 12 loci, which revealed 100 % successful genotyping in two populations from central Vietnam (Nha Trang). However, a second population from north Vietnam (Co To) could not be successfully genotyped and morphological evidence and mitochondrial variation suggests that this population represents a cryptic species of Lutraria. Comparisons of the Qang Ninh and Nha Trang populations, excluding the 2 loci out of HWE, revealed statistically significant allelic variation at 4 loci. We reported the first microsatellite loci set for the marine clam Lutraria rhynchaena and demonstrated its potential in differentiating clam populations. Additionally, a cryptic species population of Lutraria rhynchaena was identified during initial loci development, underscoring the overlooked diversity of marine clam species in Vietnam and the need to genetically characterise population representatives prior to microsatellite development. The rapid identification and validation of microsatellite loci using next-generation sequencing technology warrant its integration into future microsatellite loci development for key aquaculture species in Vietnam and more generally, aquaculture countries in the South East Asia region.

  20. Melanie Ulz: Auf dem Schlachtfeld des Empire. Männlichkeitskonzepte in der Bildproduktion zu Napoleons Ägyptenfeldzug. Marburg: Jonas Verlag 2008.

    Directory of Open Access Journals (Sweden)

    Wolfgang Schmale

    2010-11-01

    Full Text Available Der Ägyptenfeldzug Napoleons am Ende des 18. Jahrhunderts wurde im Nachhinein bildpublizistisch extensiv aufgearbeitet. Diese Publizistik wird von Melanie Ulz unter dem Gesichtspunkt dargestellter und sich wandelnder Männlichkeitskonzepte untersucht. Zentral entfaltet sich in den Visualisierungen der später so genannte „Orientalismus“. Dem europäischen/französischen Mann und Krieger wird der orientalische Mann als multivalentes und kulturell unterlegenes Wesen gegenübergestellt. Bei aller Subtilität der Kunst handelt es sich im Kern um die Gegenüberstellung von Stereotypen. Ulz kann in ihrer Studie überzeugend den sexuierten Subtext des Orientalismus nachweisen.Napoleon’s Campaign of Egypt at the end of the 18th century had afterwards been worked with and addressed in graphical media extensively. Melanie Ulz analyzes these media in respect to expressed as well as changing concepts of masculinity. The visualizations essentially display what has later been called “Orientalism”. The European/ French man and warrior is opposed to the Oriental man, who is depicted as multivalent and culturally inferior. Despite the subtlety of the art, the works basically deal with the opposition of stereotypes. Ulz manages to convincingly prove the sexualized subtext of Orientalism.

  1. A randomized trial comparing the diagnostic accuracy of visual inspection with acetic acid to Visual Inspection with Lugol's Iodine for cervical cancer screening in HIV-infected women.

    Directory of Open Access Journals (Sweden)

    Megan J Huchko

    Full Text Available Visual inspection with Acetic Acid (VIA and Visual Inspection with Lugol’s Iodine (VILI are increasingly recommended in various cervical cancer screening protocols in low-resource settings. Although VIA is more widely used, VILI has been advocated as an easier and more specific screening test. VILI has not been well-validated as a stand-alone screening test, compared to VIA or validated for use in HIV-infected women. We carried out a randomized clinical trial to compare the diagnostic accuracy of VIA and VILI among HIV-infected women. Women attending the Family AIDS Care and Education Services (FACES clinic in western Kenya were enrolled and randomized to undergo either VIA or VILI with colposcopy. Lesions suspicious for cervical intraepithelial neoplasia 2 or greater (CIN2+ were biopsied. Between October 2011 and June 2012, 654 were randomized to undergo VIA or VILI. The test positivity rates were 26.2% for VIA and 30.6% for VILI (p = 0.22. The rate of detection of CIN2+ was 7.7% in the VIA arm and 11.5% in the VILI arm (p = 0.10. There was no significant difference in the diagnostic performance of VIA and VILI for the detection of CIN2+. Sensitivity and specificity were 84.0% and 78.6%, respectively, for VIA and 84.2% and 76.4% for VILI. The positive and negative predictive values were 24.7% and 98.3% for VIA, and 31.7% and 97.4% for VILI. Among women with CD4+ count < 350, VILI had a significantly decreased specificity (66.2% compared to VIA in the same group (83.9%, p = 0.02 and compared to VILI performed among women with CD4+ count ≥ 350 (79.7%, p = 0.02. VIA and VILI had similar diagnostic accuracy and rates of CIN2+ detection among HIV-infected women.

  2. Increased Circulating Endothelial Microparticles Associated with PAK4 Play a Key Role in Ventilation-Induced Lung Injury Process

    Directory of Open Access Journals (Sweden)

    Shuming Pan

    2017-01-01

    Full Text Available Inappropriate mechanical ventilation (MV can result in ventilator-induced lung injury (VILI. Probing mechanisms of VILI and searching for effective methods are current areas of research focus on VILI. The present study aimed to probe into mechanisms of endothelial microparticles (EMPs in VILI and the protective effects of Tetramethylpyrazine (TMP against VILI. In this study, C57BL/6 and TLR4KO mouse MV models were used to explore the function of EMPs associated with p21 activated kinases-4 (PAK-4 in VILI. Both the C57BL/6 and TLR4 KO groups were subdivided into a mechanical ventilation (MV group, a TMP + MV group, and a control group. After four hours of high tidal volume (20 ml/kg MV, the degree of lung injury and the protective effects of TMP were assessed. VILI inhibited the cytoskeleton-regulating protein of PAK4 and was accompanied by an increased circulating EMP level. The intercellular junction protein of β-catenin was also decreased accompanied by a thickening alveolar wall, increased lung W/D values, and neutrophil infiltration. TMP alleviated VILI via decreasing circulating EMPs, stabilizing intercellular junctions, and alleviating neutrophil infiltration.

  3. Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice

    NARCIS (Netherlands)

    Wolthuis, Esther K; Vlaar, Alexander P J; Choi, Goda; Roelofs, Joris J T H; Juffermans, Nicole P; Schultz, Marcus J

    2009-01-01

    INTRODUCTION: Mechanical ventilation (MV) may cause ventilator-induced lung injury (VILI). Present models of VILI use exceptionally large tidal volumes, causing gross lung injury and haemodynamic shock. In addition, animals are ventilated for a relative short period of time and only after a

  4. Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice

    NARCIS (Netherlands)

    Wolthuis, Esther K.; Vlaar, Alexander Pj; Choi, Goda; Roelofs, Joris J. T. H.; Juffermans, Nicole P.; Schultz, Marcus J.

    2009-01-01

    Introduction Mechanical ventilation (MV) may cause ventilator-induced lung injury (VILI). Present models of VILI use exceptionally large tidal volumes, causing gross lung injury and haemodynamic shock. In addition, animals are ventilated for a relative short period of time and only after a 'priming'

  5. Protective effects of ghrelin in ventilator-induced lung injury in rats.

    Science.gov (United States)

    Li, Guang; Liu, Jiao; Xia, Wen-Fang; Zhou, Chen-Liang; Lv, Li-Qiong

    2017-11-01

    Ghrelin has exhibited potent anti-inflammatory effects on various inflammatory diseases. The aim of this study was to investigate the potential effects of ghrelin on a model of ventilator-induced lung injury (VILI) established in rats. Male Sprague-Dawley rats were randomly divided into three groups: low volume ventilation (LV, Vt=8ml/kg) group, a VILI group (Vt=30ml/kg), and a VILI group pretreated with ghrelin (GH+VILI). For the LV group, for the VILI and GH+VILI groups, the same parameters were applied except the tidal volume was increased to 40ml/kg. After 4h of MV, blood gas, lung elastance, and levels of inflammatory mediators, including tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, and (MIP)-2 and total protein in bronchoalveolar lavage fluid (BALF) were analyzed. Myeloperoxidase (MPO), (TLR)-4, and NF-κB, were detected in lung tissues. Water content (wet-to-dry ratio) and lung morphology were also evaluated. The VILI group had a higher acute lung injury (ALI) score, wet weight to dry ratio, MPO activity, and concentrations of inflammatory mediators (TNF-α, IL-6, IL-1β, and MIP-2) in BALF, as well as higher levels of TLR4 and NF-κB expression than the LV group (Pghrelin pretreatment (PGhrelin pretreatment also decreased TLR4 expression and NF-κB activity compared with the VILI group (PGhrelin pretreatment attenuated VILI in rats by reducing MV-induced pulmonary inflammation and might represent a novel therapeutic candidate for protection against VILI. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Filmimaailm / Aare Ermel

    Index Scriptorium Estoniae

    Ermel, Aare, 1957-2013

    2009-01-01

    Woody Alleni uusimatest filmiprojektidest. Ingmar Bergmanni kodusaare Fårö tulevikust kunstiinimeste puhke- ja loomekoduna. Lahkunud on Mikheil Kalatozišvili (19. 05. 1959 - 12. 10. 2009) ja Rosanna Schiaffino (25. 11. 1939 - 17. 10. 2009)

  7. Просто Нино - без титулов, пожалуйста! / Нино Ананиашвили ; Тийт Туумалу

    Index Scriptorium Estoniae

    Ананиашвили, Нино, 1963-

    2011-01-01

    9. ja 10. veebruaril toimuvad Eestis Gruusia riikliku balletitrupi etendused, Gruusia balletitantsija Nino Ananiašvili räägib intervjuus Gruusia balletist (ja ka emotsionaalsetest suhetest Eestiga, Venemaaga)

  8. "Macbeth": pigem silmale kui kõrvale / Maris Peters

    Index Scriptorium Estoniae

    Peters, Maris

    2010-01-01

    Gruusia kultuurinädala raames 28. mail Eesti Draamateatris etendunud Shakespeare'i "Macbethi" versioon Vaso Abashidze nimelise Thbilisi Muusika- ja Draamateateri lavastuses. Lavastaja David Doiašvili

  9. COLPOSCOPY- A PRIMARY ALTERNATIVE SCREENING TOOL FOR CERVICAL PRE-CANCER

    OpenAIRE

    Srinivas Sangisapu; Prajakta Mehendale; Aruna Menon; Venkatesan Manu

    2017-01-01

    BACKGROUND Cancer cervix is the most common and preventable malignancy in females. 80% of cases in India are detected in advanced stages. Paucity of cytologists in India is one of the important reasons for failure of screening by Pap smear. Visual Inspection of cervix with Acetic acid (VIA) and Visual Inspection of cervix with application of Lugol’s Iodine (VILI) are two alternative strategies in low resource settings. Colposcopy involves the same principles of VIA and VILI under ...

  10. Paying for Hitler's War

    DEFF Research Database (Denmark)

    Lund, Joachim

    2017-01-01

    Book review of: Jonas Scherner & Eugene N. White (eds.), Paying for Hitler's War: The Consequenses of Nazi Hegemony for Europe (NY: Cambridge University Press, 2016)......Book review of: Jonas Scherner & Eugene N. White (eds.), Paying for Hitler's War: The Consequenses of Nazi Hegemony for Europe (NY: Cambridge University Press, 2016)...

  11. Ecology and Pedagogy: On the Educational Implications of Postwar Environmental Philosophy

    Science.gov (United States)

    Hotam, Yotam

    2010-01-01

    Environmentalism, an ethical imperative to preserve and protect nature, has become in the last decade a central ethical, political and pedagogic theme. Against this background, this article focuses on the postwar philosophy of the German-Jewish scholar Hans Jonas (1903-93). It points to Jonas's radical theory of pedagogic responsibility, and to…

  12. Kaido Ole seintel ja kaante vahel / Valner Valme

    Index Scriptorium Estoniae

    Valme, Valner, 1970-

    2007-01-01

    Kunstnik Kaido Ole (sünd. 1963) eluloolisi andmeid, looming. Eesti Kunstiakadeemia andis välja kataloogi "Ole", toimetaja Eero Epner. Kunstinäitus "Jonas & Kaido" koos Jonas Gasiunasega Vilniuse Vartai galeriis. Näitus "Hümn" Vaal galeriis

  13. Physiology in Medicine: Understanding dynamic alveolar physiology to minimize ventilator-induced lung injury.

    Science.gov (United States)

    Nieman, Gary F; Satalin, Josh; Kollisch-Singule, Michaela; Andrews, Penny; Aiash, Hani; Habashi, Nader M; Gatto, Louis A

    2017-06-01

    Acute respiratory distress syndrome (ARDS) remains a serious clinical problem with the main treatment being supportive in the form of mechanical ventilation. However, mechanical ventilation can be a double-edged sword: if set improperly, it can exacerbate the tissue damage caused by ARDS; this is known as ventilator-induced lung injury (VILI). To minimize VILI, we must understand the pathophysiologic mechanisms of tissue damage at the alveolar level. In this Physiology in Medicine paper, the dynamic physiology of alveolar inflation and deflation during mechanical ventilation will be reviewed. In addition, the pathophysiologic mechanisms of VILI will be reviewed, and this knowledge will be used to suggest an optimal mechanical breath profile (MB P : all airway pressures, volumes, flows, rates, and the duration that they are applied at both inspiration and expiration) necessary to minimize VILI. Our review suggests that the current protective ventilation strategy, known as the "open lung strategy," would be the optimal lung-protective approach. However, the viscoelastic behavior of dynamic alveolar inflation and deflation has not yet been incorporated into protective mechanical ventilation strategies. Using our knowledge of dynamic alveolar mechanics (i.e., the dynamic change in alveolar and alveolar duct size and shape during tidal ventilation) to modify the MB P so as to minimize VILI will reduce the morbidity and mortality associated with ARDS. Copyright © 2017 the American Physiological Society.

  14. Methylene Blue in Ventilator-Induced Lung Injury after Pneumonectomy: an Experimental Study

    Directory of Open Access Journals (Sweden)

    Ye. V Suborov

    2007-01-01

    Full Text Available Objective: to study the expediency and efficiency of using methylene blue (MB on a model of pneumectomy (PE and subsequent ventilator-induced lung injury (VILI in sheep. Materials and methods. The study was conducted at the Research Laboratory of University of Tromse. The experiment included 23 sheep weighing 41.0±4.9 kg. Thoracotomy and right-sided pneumonectomy were performed in the animals under general anesthesia and controlled artificial ventilation. After measurement of the parameters of systemic hemodynamics and extravascular water of the lung (EVWL, the animals were divided into 3 groups: 1 a control group (CG, n=7 with a tidal volume (TV of 6 ml/kg and an end-expiratory positive pressure (PEEP of 2 cm H2O; 2 a VILI group (n=9 with a TV of 12 ml/kg and a PEEP of 0 cm H2O; 3 a group of MB (n=7 that was given in parallel with a damaging ventilation mode. The thermodilution technique (using a Cold Z-021 monitor, (Pulsion, Germany was employed to measure volumetric parameters and EVWL. The parameters of pulmonary hemodynamics, respiratory mechanics, and blood gas composition were recorded. Results: After its reduction at PE, EVWL index increased during damaging ventilation in the VILI and MB groups. In addition, there was an increase in pulmonary artery wedge pressure after PE in the MB and VILI groups. In the latter group, arterial hypoxemia was observed at the end of the experiment. Along with this, after PE pulmonary compliance decreased and airway pressure elevated in the VILI and MB groups. Conclusion: In the presented model of VILI, MB does not prevent the development of postp-neumectomic edema of the lung. Key words: thermochromodilution, acute lung injury, pneumectomy, ventilator-induced lung injury, postpneumectomic edema of the lung, methylene blue.

  15. High-frequency oscillatory ventilation in ALI/ARDS.

    Science.gov (United States)

    Ali, Sammy; Ferguson, Niall D

    2011-07-01

    In the last 2 decades, our goals for mechanical ventilatory support in patients with acute respiratory distress syndrome (ARDS) or acute lung injury (ALI) have changed dramatically. Several randomized controlled trials have built on a substantial body of preclinical work to demonstrate that the way in which we employ mechanical ventilation has an impact on important patient outcomes. Avoiding ventilator-induced lung injury (VILI) is now a major focus when clinicians are considering which ventilatory strategy to employ in patients with ALI/ARDS. Physicians are searching for methods that may further limit VILI, while still achieving adequate gas exchange. Copyright © 2011 Elsevier Inc. All rights reserved.

  16. Screening for cervical cancer among HIV-positive and HIV-negative women in Cameroon using simultaneous co-testing with careHPV DNA testing and visual inspection enhanced by digital cervicography: Findings of initial screening and one-year follow-up.

    Science.gov (United States)

    Cholli, Preetam; Bradford, Leslie; Manga, Simon; Nulah, Kathleen; Kiyang, Edith; Manjuh, Florence; DeGregorio, Geneva; Ogembo, Rebecca K; Orock, Enow; Liu, Yuxin; Wamai, Richard G; Sheldon, Lisa Kennedy; Gona, Philimon N; Sando, Zacharie; Welty, Thomas; Welty, Edith; Ogembo, Javier Gordon

    2018-01-01

    The World Health Organization (WHO)'s cervical cancer screening guidelines for limited-resource settings recommend sequential screening followed by same-day treatment under a "screen-and-treat" approach. We aimed to (1) assess feasibility and clinical outcomes of screening HIV-positive and HIV-negative Cameroonian women by pairing visual inspection with acetic acid and Lugol's iodine enhanced by digital cervicography (VIA/VILI-DC) with careHPV, a high-risk human papillomavirus (HR-HPV) nucleic acid test designed for low-resource settings; and (2) determine persistence of HR-HPV infection after one-year follow-up to inform optimal screening, treatment, and follow-up algorithms. We co-tested 913 previously unscreened women aged ≥30years and applied WHO-recommended treatment for all VIA/VILI-DC-positive women. Baseline prevalence of HR-HPV and HIV were 24% and 42%, respectively. On initial screen, 44 (5%) women were VIA/VILI-DC-positive, of whom 22 had HR-HPV infection, indicating 50% of women screened false-positive and would have been triaged for unnecessary same-day treatment. VIA/VILI-DC-positive women with HIV infection were three times more likely to be HR-HPV-positive than HIV-negative women (65% vs. 20%). All women positive for either VIA/VILI-DC or HR-HPV (n=245) were invited for repeat co-testing after one year, of which 136 (56%) returned for follow-up. Of 122 women who were HR-HPV-positive on initial screen, 60 (49%) re-tested negative, of whom 6 had received treatment after initial screen, indicating that 44% of initially HR-HPV-positive women spontaneously cleared infection after one year without treatment. Women with HIV were more likely to remain HR-HPV-positive on follow-up than HIV-negative women (61% vs. 22%, p<0.001). Treatment was offered to all VIA/VILI-DC positive women on initial screen, and to all women screening VIA/VILI-DC or HR-HPV positive on follow-up. We found careHPV co-testing with VIA/VILI-DC to be feasible and valuable in

  17. Medical Research Pays Off for All Americans

    Science.gov (United States)

    ... the "March of Dimes." It helped develop two vaccines. The first, by Dr. Jonas Salk at the University of Pittsburgh, in 1955, and the second, in 1962, by Dr. Albert Sabin, at the Cincinnati Children's Hospital Medical Center – have ...

  18. Unified Chiral models of mesons and baryons

    International Nuclear Information System (INIS)

    Mendez-Galain, R.; Ripka, G.

    1990-01-01

    Unified Chiral models of mesons and baryons are presented. Emphasis is placed on the underlying quark structure of hadrons including the Skyrmion. The Nambu Jona-Lasinio model with vector mesons is discussed

  19. Kais-Vesik said ebameeldiva vastase / Andres Kalvik

    Index Scriptorium Estoniae

    Kalvik, Andres, 1982-

    2007-01-01

    Stavangeris Suure Slämmi alagrupis kolmanda koha saanud ning koha 24 parema seas taganud Kristjan Kais ja Rivo Vesik lähevad play-off'i avaringis vastamisi Saksamaa duoga Mischa Urbatzka - Jonas Reckermann

  20. Success in Opposite Direction: Strategic Culture and the French Experience in Indochina, the Suez, and Algeria, 1945-1962

    Science.gov (United States)

    2015-05-21

    School of Advanced Military Studies Henry A. Arnold III, COL, IN Accepted this 21st day of May 2015 by: ___________________________________, Director...Heiko; Giegerich Biehl, Bastian; Jonas, Alexandra ( Potsdam , DE: Springer VS, 2013), 9. 8 Darryl Howlett, The Future of Strategic Culture, Comparative...Policies across the Continent. Potsdam , DE: Springer VS, 2013. cConcepts presented by Biehl, Giegerich, and Jonas. Table 2.2 Evaluation criteria for

  1. Using Clickers in the Classroom to Increase the Level of Student Interaction

    Science.gov (United States)

    2008-12-01

    and Menachem Jona believe “experience is the best teacher” and “the best teachers are typically the best storytellers ” (Schank & Jona, 1991). Keeping...Creation of community – At the beginning of a semester or quarter, CRS can be used to create awareness in a group or class. This can contribute to the...Table 1 (pages 24-25). Each of these brands was compared on various characteristics: response capabilities, system requirements, and overall

  2. Поступ слона и полёт орла сошлись на "Диком поле" / Борис Тух

    Index Scriptorium Estoniae

    Тух, Борис, 1946-

    2009-01-01

    Moskvas anti taas välja teineteisega konkureerivaid filmiauhindu "Kuldne Kotkas" ("Zolotoi Orjol") ja "Valge Elevant" ("Belõi Slon"). Seekord võitis mõlemad parima filmina Mihhail Kalatozišvili film "Metsik põld" ("Dikoje polje")

  3. Триумф "Стиляг" на "Диком поле" / Анна Хрусталева

    Index Scriptorium Estoniae

    Хрусталева, Анна

    2009-01-01

    Vene 2008.a. filmimuusikal "Lõngused", režissöör Valeri Todorovski, võitis parima filmi Nika auhinna. Mitmeid auhindu said ka Mihhail Kalatozišvili "Metsik väli" ja Aleksei German jun. "Pabersõdur". Ka teistest auhinnasaajatest

  4. Helping hand from the Baltics: Lithuania deepens support for Georgia / Michael Durnan

    Index Scriptorium Estoniae

    Durnan, Michael

    2009-01-01

    Augustisõjast räsitud Gruusia pealinnas toimunud massimeeleavaldustel nõuti president Mihhail Saakašvili tagasiastumist. Leedu president Valdas Adamkus kutsub lääneriike avaldama suuremat toetust Gruusiale ning mõistab hukka Vene Föderatsiooni Gruusia-vastase tegevuse

  5. Integrated Stress Response Mediates Epithelial Injury in Mechanical Ventilation.

    Science.gov (United States)

    Dolinay, Tamas; Himes, Blanca E; Shumyatcher, Maya; Lawrence, Gladys Gray; Margulies, Susan S

    2017-08-01

    Ventilator-induced lung injury (VILI) is a severe complication of mechanical ventilation that can lead to acute respiratory distress syndrome. VILI is characterized by damage to the epithelial barrier with subsequent pulmonary edema and profound hypoxia. Available lung-protective ventilator strategies offer only a modest benefit in preventing VILI because they cannot impede alveolar overdistension and concomitant epithelial barrier dysfunction in the inflamed lung regions. There are currently no effective biochemical therapies to mitigate injury to the alveolar epithelium. We hypothesize that alveolar stretch activates the integrated stress response (ISR) pathway and that the chemical inhibition of this pathway mitigates alveolar barrier disruption during stretch and mechanical ventilation. Using our established rat primary type I-like alveolar epithelial cell monolayer stretch model and in vivo rat mechanical ventilation that mimics the alveolar overdistension seen in acute respiratory distress syndrome, we studied epithelial responses to mechanical stress. Our studies revealed that the ISR signaling pathway is a key modulator of epithelial permeability. We show that prolonged epithelial stretch and injurious mechanical ventilation activate the ISR, leading to increased alveolar permeability, cell death, and proinflammatory signaling. Chemical inhibition of protein kinase RNA-like endoplasmic reticulum kinase, an upstream regulator of the pathway, resulted in decreased injury signaling and improved barrier function after prolonged cyclic stretch and injurious mechanical ventilation. Our results provide new evidence that therapeutic targeting of the ISR can mitigate VILI.

  6. Koolitaja kogemus / Enn Siim

    Index Scriptorium Estoniae

    Siim, Enn

    2002-01-01

    Vene koolide õpetajate täienduskoolitusprobleeme, integratsiooniprobleemide lahendamisest Kanada hariduses, humanistliku pedagoogika rakendamisest Tallinna Ümera Põhikoolis ja Venemaal Peterburi koolides. Eestis on loodud Humanistliku Pedagoogika Selts, humanistliku pedagoogika asjatundja Venemaal on pedagoogikadoktor professor Šalva Amonašvili

  7. Southern Caucasus in Perspective. The scholarly debate through the pages of Seminarium Kondakovianum and Skythika (1927-1938)

    Czech Academy of Sciences Publication Activity Database

    Lovino, Francesco

    -, Supplementum (2016), s. 36-51 ISSN 2336-3452 Institutional support: RVO:68378033 Keywords : art and archaeology historiography * Seminarium Kondakovianum * Michail Rostovtzeff * Stefan Przeworski * Georgij Čubinašvili * Caucasus * church of Saint George in Samtsevrisi * animal style * bronze statuettes Subject RIV: AL - Art, Architecture, Cultural Heritage

  8. Lung-protective ventilation in neonatology

    NARCIS (Netherlands)

    van Kaam, Anton

    2011-01-01

    Ventilator-induced lung injury (VILI) is considered an important risk factor in the development of bronchopulmonary dysplasia (BPD) and is primarily caused by overdistension (volutrauma) and repetitive opening and collapse (atelectrauma) of terminal lung units. Lung-protective ventilation should

  9. Author Details

    African Journals Online (AJOL)

    Fine needle aspiration cytology of thyroid nodules at Kenyatta National Hospital, Nairobi Abstract · Vol 90, No 10 (2013) - Articles Cryotherapy Following Visual Inspection with Acetic Acid and Lugol's Iodine (Via/Vili) in Khwisero, Western Kenya: Lesson from the Field Affecting Policy and Practice Abstract PDF. ISSN: 0012- ...

  10. Author Details

    African Journals Online (AJOL)

    Ngichabe, SK. Vol 89, No 4 (2012) - Articles Reminder systems for self uterine massage in the prevention of postpartum blood loss. Abstract PDF · Vol 90, No 10 (2013) - Articles Cryotherapy Following Visual Inspection with Acetic Acid and Lugol's Iodine (Via/Vili) in Khwisero, Western Kenya: Lesson from the Field Affecting ...

  11. Metabolic acidosis may be as protective as hypercapnic acidosis in an ex-vivo model of severe ventilator-induced lung injury: a pilot study

    Directory of Open Access Journals (Sweden)

    Patsouris Efstratios

    2011-04-01

    Full Text Available Abstract Background There is mounting experimental evidence that hypercapnic acidosis protects against lung injury. However, it is unclear if acidosis per se rather than hypercapnia is responsible for this beneficial effect. Therefore, we sought to evaluate the effects of hypercapnic (respiratory versus normocapnic (metabolic acidosis in an ex vivo model of ventilator-induced lung injury (VILI. Methods Sixty New Zealand white rabbit ventilated and perfused heart-lung preparations were used. Six study groups were evaluated. Respiratory acidosis (RA, metabolic acidosis (MA and normocapnic-normoxic (Control - C groups were randomized into high and low peak inspiratory pressures, respectively. Each preparation was ventilated for 1 hour according to a standardized ventilation protocol. Lung injury was evaluated by means of pulmonary edema formation (weight gain, changes in ultrafiltration coefficient, mean pulmonary artery pressure changes as well as histological alterations. Results HPC group gained significantly greater weight than HPMA, HPRA and all three LP groups (P = 0.024, while no difference was observed between HPMA and HPRA groups regarding weight gain. Neither group differ on ultrafiltration coefficient. HPMA group experienced greater increase in the mean pulmonary artery pressure at 20 min (P = 0.0276 and 40 min (P = 0.0012 compared with all other groups. Histology scores were significantly greater in HP vs. LP groups (p Conclusions In our experimental VILI model both metabolic acidosis and hypercapnic acidosis attenuated VILI-induced pulmonary edema implying a mechanism other than possible synergistic effects of acidosis with CO2 for VILI attenuation.

  12. Metabolic acidosis may be as protective as hypercapnic acidosis in an ex-vivo model of severe ventilator-induced lung injury: a pilot study.

    Science.gov (United States)

    Kapetanakis, Theodoros; Siempos, Ilias I; Metaxas, Eugenios I; Kopterides, Petros; Agrogiannis, George; Patsouris, Efstratios; Lazaris, Andreas C; Stravodimos, Konstantinos G; Roussos, Charis; Armaganidis, Apostolos

    2011-04-13

    There is mounting experimental evidence that hypercapnic acidosis protects against lung injury. However, it is unclear if acidosis per se rather than hypercapnia is responsible for this beneficial effect. Therefore, we sought to evaluate the effects of hypercapnic (respiratory) versus normocapnic (metabolic) acidosis in an ex vivo model of ventilator-induced lung injury (VILI). Sixty New Zealand white rabbit ventilated and perfused heart-lung preparations were used. Six study groups were evaluated. Respiratory acidosis (RA), metabolic acidosis (MA) and normocapnic-normoxic (Control - C) groups were randomized into high and low peak inspiratory pressures, respectively. Each preparation was ventilated for 1 hour according to a standardized ventilation protocol. Lung injury was evaluated by means of pulmonary edema formation (weight gain), changes in ultrafiltration coefficient, mean pulmonary artery pressure changes as well as histological alterations. HPC group gained significantly greater weight than HPMA, HPRA and all three LP groups (P = 0.024), while no difference was observed between HPMA and HPRA groups regarding weight gain. Neither group differ on ultrafiltration coefficient. HPMA group experienced greater increase in the mean pulmonary artery pressure at 20 min (P = 0.0276) and 40 min (P = 0.0012) compared with all other groups. Histology scores were significantly greater in HP vs. LP groups (p < 0.001). In our experimental VILI model both metabolic acidosis and hypercapnic acidosis attenuated VILI-induced pulmonary edema implying a mechanism other than possible synergistic effects of acidosis with CO2 for VILI attenuation.

  13. Positive pressure ventilation with the open lung concept optimizes gas exchange and reduces ventilator-induced lung injury in newborn piglets

    NARCIS (Netherlands)

    van Kaam, Anton H.; de Jaegere, Anne; Haitsma, Jack J.; van Aalderen, Wim M.; Kok, Joke H.; Lachmann, Burkhard

    2003-01-01

    Previous studies demonstrated that high-frequency oscillatory ventilation using the open lung concept (OLC resulted in superior gas exchange and a reduction in ventilator-induced lung injury (VILI). We hypothesized that these beneficial effects could also be achieved by applying the OLC during

  14. Perceptions of risk and barriers to cervical cancer screening at Moi ...

    African Journals Online (AJOL)

    Background: Affordable screening cervical cancer methods using visual inspection with acetic acid (VIA) and with Lugol's iodine (VILI) are being developed. Scaling up of screening services requires an understanding of the user perceptions about screening. Objectives: Determine the perceptions of risk and barriers to ...

  15. Collegiality in education: a case study

    African Journals Online (AJOL)

    Erna Kinsey

    This case study therefore investigated the effects of a collegial management style on teaching and learning ... resources cannot solely guarantee success at matriculation level. ... vily on school principals, their management teams and the governing .... may be necessary to employ the notion of building with a new member.

  16. Are lung-protective ventilation strategies worth the effort? | Slinger ...

    African Journals Online (AJOL)

    Nonphysiological ventilation in healthy lungs induces acute lung injury (ALI). Protective lung ventilation in patients with ALI improves outcome. Protective lung ventilation in noninjured lungs and in the absence of a primary pulmonary insult may initiate ventilation-induced lung injury (VILI), as evidenced by inflammatory ...

  17. Cervical digital photography for screening of uterine cervix cancer and its precursor lesions in developing countries.

    Science.gov (United States)

    Hillmann, Elise de Castro; Dos Reis, Ricardo; Monego, Heleusa; Appel, Márcia; Hammes, Luciano Serpa; Rivoire, Waldemar Augusto; Capp, Edison

    2013-07-01

    This study aims to evaluate and to compare the performance of cervical digital photography (CDP) to the visual inspection with acetic acid (VIA) and visual inspection with Lugol's iodine (VILI) methods for screening the uterine cervix cancer and its precursor lesions in developing countries. A cross-sectional study was performed in Brazil. 176 women were evaluated by VIA, VILI, CDP with acetic acid and CDP with Lugol's iodine. Kappa statistic was used to estimate the interobserver and intermethod agreement. Sensitivity, specificity and diagnostic accuracy of the four methods (VIA, VILI, CDP with acetic acid, CDP with Lugol's iodine) was calculated. Interobserver agreement for CDP with acetic acid was K = 0.441 and for CDP with Lugol's iodine was K = 0.533; intermethod agreement of VIA and CDP with acetic acid, K = 0.559; and of VILI and CDP with Lugol's iodine, K = 0.507. Sensitivity and specificity of CDP with acetic acid were 84.00 and 95.83 %, and of CDP with Lugol's iodine were 88.00 and 97.26 %, respectively. The diagnostic accuracy of CDP with acetic acid and CDP with Lugol's iodine was 92.78 and 94.90 %, respectively. This was the first study to assess the CDP with Lugol's iodine performance, which had similar performance to the CDP with acetic acid. CDP is considered a promising method for screening the uterine cervix cancer and its precursor lesions in developing countries.

  18. Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice.

    Science.gov (United States)

    Müller-Redetzky, Holger C; Felten, Matthias; Hellwig, Katharina; Wienhold, Sandra-Maria; Naujoks, Jan; Opitz, Bastian; Kershaw, Olivia; Gruber, Achim D; Suttorp, Norbert; Witzenrath, Martin

    2015-01-28

    Lung-protective ventilation reduced acute respiratory distress syndrome (ARDS) mortality. To minimize ventilator-induced lung injury (VILI), tidal volume is limited, high plateau pressures are avoided, and positive end-expiratory pressure (PEEP) is applied. However, the impact of specific ventilatory patterns on VILI is not well defined. Increasing inspiratory time and thereby the inspiratory/expiratory ratio (I:E ratio) may improve oxygenation, but may also be harmful as the absolute stress and strain over time increase. We thus hypothesized that increasing inspiratory time and I:E ratio aggravates VILI. VILI was induced in mice by high tidal-volume ventilation (HVT 34 ml/kg). Low tidal-volume ventilation (LVT 9 ml/kg) was used in control groups. PEEP was set to 2 cm H2O, FiO2 was 0.5 in all groups. HVT and LVT mice were ventilated with either I:E of 1:2 (LVT 1:2, HVT 1:2) or 1:1 (LVT 1:1, HVT 1:1) for 4 hours or until an alternative end point, defined as mean arterial blood pressure below 40 mm Hg. Dynamic hyperinflation due to the increased I:E ratio was excluded in a separate group of animals. Survival, lung compliance, oxygenation, pulmonary permeability, markers of pulmonary and systemic inflammation (leukocyte differentiation in lung and blood, analyses of pulmonary interleukin-6, interleukin-1β, keratinocyte-derived chemokine, monocyte chemoattractant protein-1), and histopathologic pulmonary changes were analyzed. LVT 1:2 or LVT 1:1 did not result in VILI, and all individuals survived the ventilation period. HVT 1:2 decreased lung compliance, increased pulmonary neutrophils and cytokine expression, and evoked marked histologic signs of lung injury. All animals survived. HVT 1:1 caused further significant worsening of oxygenation, compliance and increased pulmonary proinflammatory cytokine expression, and pulmonary and blood neutrophils. In the HVT 1:1 group, significant mortality during mechanical ventilation was observed. According to the "baby lung

  19. Dexamethasone attenuates VEGF expression and inflammation but not barrier dysfunction in a murine model of ventilator-induced lung injury.

    Directory of Open Access Journals (Sweden)

    Maria A Hegeman

    Full Text Available BACKGROUND: Ventilator-induced lung injury (VILI is characterized by vascular leakage and inflammatory responses eventually leading to pulmonary dysfunction. Vascular endothelial growth factor (VEGF has been proposed to be involved in the pathogenesis of VILI. This study examines the inhibitory effect of dexamethasone on VEGF expression, inflammation and alveolar-capillary barrier dysfunction in an established murine model of VILI. METHODS: Healthy male C57Bl/6 mice were anesthetized, tracheotomized and mechanically ventilated for 5 hours with an inspiratory pressure of 10 cmH2O ("lower" tidal volumes of ∼7.5 ml/kg; LVT or 18 cmH2O ("higher" tidal volumes of ∼15 ml/kg; HVT. Dexamethasone was intravenously administered at the initiation of HVT-ventilation. Non-ventilated mice served as controls. Study endpoints included VEGF and inflammatory mediator expression in lung tissue, neutrophil and protein levels in bronchoalveolar lavage fluid, PaO2 to FiO2 ratios and lung wet to dry ratios. RESULTS: Particularly HVT-ventilation led to alveolar-capillary barrier dysfunction as reflected by reduced PaO2 to FiO2 ratios, elevated alveolar protein levels and increased lung wet to dry ratios. Moreover, VILI was associated with enhanced VEGF production, inflammatory mediator expression and neutrophil infiltration. Dexamethasone treatment inhibited VEGF and pro-inflammatory response in lungs of HVT-ventilated mice, without improving alveolar-capillary permeability, gas exchange and pulmonary edema formation. CONCLUSIONS: Dexamethasone treatment completely abolishes ventilator-induced VEGF expression and inflammation. However, dexamethasone does not protect against alveolar-capillary barrier dysfunction in an established murine model of VILI.

  20. Linking Ventilator Injury-Induced Leak across the Blood-Gas Barrier to Derangements in Murine Lung Function

    Directory of Open Access Journals (Sweden)

    Bradford J. Smith

    2017-07-01

    Full Text Available Mechanical ventilation is vital to the management of acute respiratory distress syndrome, but it frequently leads to ventilator-induced lung injury (VILI. Understanding the pathophysiological processes involved in the development of VILI is an essential prerequisite for improving lung-protective ventilation strategies. The goal of this study was to relate the amount and nature of material accumulated in the airspaces to biomarkers of injury and the derecruitment behavior of the lung in VILI. Forty-nine BALB/c mice were mechanically ventilated with combinations of tidal volume and end-expiratory pressures to produce varying degrees of overdistension and atelectasis while lung function was periodically assessed. Total protein, serum protein, and E-Cadherin levels were measured in bronchoalveolar lavage fluid (BALF. Tissue injury was assessed by histological scoring. We found that both high tidal volume and zero positive end-expiratory pressure were necessary to produce significant VILI. Increased BALF protein content was correlated with increased lung derecruitability, elevated peak pressures, and histological evidence of tissue injury. Blood derived molecules were present in the BALF in proportion to histological injury scores and epithelial injury, reflected by E-Cadherin levels in BALF. We conclude that repetitive recruitment is an important factor in the pathogenesis of VILI that exacerbates injury associated with tidal overdistension. Furthermore, the dynamic mechanical behavior of the injured lung provides a means to assess both the degree of tissue injury and the nature and amount of blood-derived fluid and proteins that accumulate in the airspaces.

  1. Effects of sevoflurane on ventilator induced lung injury in a healthy lung experimental model.

    Science.gov (United States)

    Romero, A; Moreno, A; García, J; Sánchez, C; Santos, M; García, J

    2016-01-01

    Ventilator-induced lung injury (VILI) causes a systemic inflammatory response in tissues, with an increase in IL-1, IL-6 and TNF-α in blood and tissues. Cytoprotective effects of sevoflurane in different experimental models are well known, and this protective effect can also be observed in VILI. The objective of this study was to assess the effects of sevoflurane in VILI. A prospective, randomized, controlled study was designed. Twenty female rats were studied. The animals were mechanically ventilated, without sevoflurane in the control group and sevoflurane 3% in the treated group (SEV group). VILI was induced applying a maximal inspiratory pressure of 35 cmH2O for 20 min without any positive end-expiratory pressure for 20 min (INJURY time). The animals were then ventilated 30 min with a maximal inspiratory pressure of 12 cmH2O and 3 cmH2O positive end-expiratory pressure (time 30 min POST-INJURY), at which time the animals were euthanized and pathological and biomarkers studies were performed. Heart rate, invasive blood pressure, pH, PaO2, and PaCO2 were recorded. The lung wet-to-dry weight ratio was used as an index of lung edema. No differences were found in the blood gas analysis parameters or heart rate between the 2 groups. Blood pressure was statistically higher in the control group, but still within the normal clinical range. The percentage of pulmonary edema and concentrations of TNF-α and IL-6 in lung tissue in the SEV group were lower than in the control group. Sevoflurane attenuates VILI in a previous healthy lung in an experimental subclinical model in rats. Copyright © 2015 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Publicado por Elsevier España, S.L.U. All rights reserved.

  2. The role of the acute phase protein PTX3 in the ventilator-induced lung injury

    Directory of Open Access Journals (Sweden)

    JM Real

    2008-06-01

    Full Text Available The pentraxin 3 (PTX3 is an acute phase proinflammatory protein produced by fibroblasts and alveolar epithelial cells. We have previously demonstrated that PTX3 is a key modulator of inflammation. Mechanical ventilation (MV is a life saving therapeutic approach for patients with acute lung injury that, nevertheless could lead to an inflammatory response and tissue injury (ventilator-induced lung injury: VILI, representing a major cause of iatrogenic lung damage in intensive units. Our objective was to investigate the role of PTX3 in VILI. PTX3 transgenic, knockout and Wt control mice (n = 12/group were ventilated (45ml·kg–1 until respiratory system Elastance increased 50% (Ers150%, an indicator of VILI. Histological analysis demonstrated that using a Ers150% was appropriate for our analysis since identical degrees of inflammation were observed in Tg, KO and Wt mice as assessed by leukocyte infiltration, oedema, alveolar collapse and number of breaks in alveolar septa. However, Tg mice reached Ers150% faster than Wt controls (p = 0.0225. We also showed that the lack of PTX3 does not abolish the occurrence of VILI in KOs. Gene expression profile of PTX3, IL-1beta, IL-6, KC, IFNgamma, TGFbeta and PCIII were investigated by QPCR. MV drastically up modulated PTX3 as well as IL-1beta, IL-6, IFNgamma and KC. Alternatively, mice were ventilated for 20, 40 and 60 min. The faster kinetics of Tg mice to reach Ers150% was accompanied by an earlier augmentation of IL-1b and PTX3 expression. The kinetics of local PTX3 expression in the lungs of ventilated mice strongly suggests the involvement of this pentraxin in the pathogenesis of VILI.

  3. Performance of alternative strategies for primary cervical cancer screening in sub-Saharan Africa: systematic review and meta-analysis of diagnostic test accuracy studies

    Science.gov (United States)

    Combescure, Christophe; Fokom-Defo, Victoire; Tebeu, Pierre Marie; Vassilakos, Pierre; Kengne, André Pascal; Petignat, Patrick

    2015-01-01

    Objective To assess and compare the accuracy of visual inspection with acetic acid (VIA), visual inspection with Lugol’s iodine (VILI), and human papillomavirus (HPV) testing as alternative standalone methods for primary cervical cancer screening in sub-Saharan Africa. Design Systematic review and meta-analysis of diagnostic test accuracy studies. Data sources Systematic searches of multiple databases including Medline, Embase, and Scopus for studies published between January 1994 and June 2014. Review methods Inclusion criteria for studies were: alternative methods to cytology used as a standalone test for primary screening; study population not at particular risk of cervical cancer (excluding studies focusing on HIV positive women or women with gynaecological symptoms); women screened by nurses; reference test (colposcopy and directed biopsies) performed at least in women with positive screening results. Two reviewers independently screened studies for eligibility and extracted data for inclusion, and evaluated study quality using the quality assessment of diagnostic accuracy studies 2 (QUADAS-2) checklist. Primary outcomes were absolute accuracy measures (sensitivity and specificity) of screening tests to detect cervical intraepithelial neoplasia grade 2 or worse (CIN2+). Results 15 studies of moderate quality were included (n=61 381 for VIA, n=46 435 for VILI, n=11 322 for HPV testing). Prevalence of CIN2+ did not vary by screening test and ranged from 2.3% (95% confidence interval 1.5% to 3.3%) in VILI studies to 4.9% (2.7% to 7.8%) in HPV testing studies. Positivity rates of VILI, VIA, and HPV testing were 16.5% (9.8% to 24.7%), 16.8% (11.0% to 23.6%), and 25.8% (17.4% to 35.3%), respectively. Pooled sensitivity was higher for VILI (95.1%; 90.1% to 97.7%) than VIA (82.4%; 76.3% to 87.3%) in studies where the reference test was performed in all women (Psub-Saharan Africa, VILI is a simple and affordable alternative to cytology that demonstrates higher

  4. Pre-treatment with dexamethasone attenuates experimental ventilator-induced lung injury.

    Science.gov (United States)

    Reis, Fernando Fonseca Dos; Reboredo, Maycon de Moura; Lucinda, Leda Marília Fonseca; Bianchi, Aydra Mendes Almeida; Rabelo, Maria Aparecida Esteves; Fonseca, Lídia Maria Carneiro da; Oliveira, Júlio César Abreu de; Pinheiro, Bruno Valle

    2016-01-01

    To evaluate the effects that administering dexamethasone before the induction of ventilator-induced lung injury (VILI) has on the temporal evolution of that injury. Wistar rats were allocated to one of three groups: pre-VILI administration of dexamethasone (dexamethasone group); pre-VILI administration of saline (control group); or ventilation only (sham group). The VILI was induced by ventilation at a high tidal volume. Animals in the dexamethasone and control groups were euthanized at 0, 4, 24, and 168 h after VILI induction. We analyzed arterial blood gases, lung edema, cell counts (total and differential) in the BAL fluid, and lung histology. At 0, 4, and 24 h after VILI induction, acute lung injury (ALI) scores were higher in the control group than in the sham group (p grupos: administração de dexametasona pré-LPIVM (grupo dexametasona); administração de salina pré-LPIVM (grupo controle); e somente ventilação (grupo sham). A LPIVM foi realizada por ventilação com volume corrente alto. Os animais dos grupos dexametasona e controle foram sacrificados em 0, 4, 24 e 168 h após LPIVM. Analisamos gasometria arterial, edema pulmonar, contagens de células (totais e diferenciais) no lavado broncoalveolar e histologia de tecido pulmonar. Em 0, 4 e 24 h após LPIVM, os escores de lesão pulmonar aguda (LPA) foram maiores no grupo controle que no grupo sham (p grupo dexametasona não foi significativamente diferente daquele observado no grupo sham e foi menor que o observado no grupo controle (p grupos controle e dexametasona, com pico em 4 h após LPIVM (p grupo dexametasona que no grupo controle em 4 e 24 h após LPIVM (p grupo controle. A administração de dexametasona antes de LPIVM atenua os efeitos da lesão em ratos Wistar. Os mecanismos moleculares dessa lesão e o possível papel clínico dos corticosteroides na LPIVM ainda precisam ser elucidados.

  5. A Gnostic Critic of Modernity

    DEFF Research Database (Denmark)

    Cahana, Jonathan

    2017-01-01

    newly discovered texts from Nag Hammadi, as a well-spring of ideas that can be used to heal modernity. Through the application of Gnosticism, Jonas was able to lay bare not only the nihilism lurking in Martin Heidegger’s Being and Time, but also the philosophical shortcomings that were to culminate...... in Heidegger’s later “paganism” and his interrelated alliance with Nazism. Furthermore, I exemplify how Jonas reemployed Gnosticism again in his later years to critique modern scientific nihilism. The conclusion illustrates how Jonas employed to the utmost the threefold potential of this renegade late......-antique religion: Gnosticism’s extravagant metaphysics; its suspicion of nature and fate; and its refusal of utter nihilism....

  6. Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Chien-Sheng [Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA (United States); Division of Thoracic Surgery, Department of Surgery, Taipei-Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan (China); Kawamura, Tomohiro; Peng, Ximei [Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA (United States); Tochigi, Naobumi [Department of Pathology, University of Pittsburgh Medical Center, PA (United States); Shigemura, Norihisa [Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA (United States); Billiar, Timothy R. [Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA (United States); Nakao, Atsunori, E-mail: anakao@imap.pitt.edu [Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA (United States); Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA (United States); Toyoda, Yoshiya [Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA (United States)

    2011-05-06

    Highlights: {yields} Hydrogen is a regulatory molecule with antiinflammatory and antiapoptotic protective effects. {yields} There is very limited information on the pathways regulated in vivo by the hydrogen. {yields} Antiapoptotic abilities of hydrogen were explained by upregulation of the antiapoptotic gene. {yields} NF{kappa}B activation during hydrogen treatment was correlated with elevated antiapoptotic protein. {yields} NF{kappa}B activation associated with increase Bcl-2 may contribute to cytoprotection of hydrogen. -- Abstract: We recently demonstrated the inhalation of hydrogen gas, a novel medical therapeutic gas, ameliorates ventilator-induced lung injury (VILI); however, the molecular mechanisms by which hydrogen ameliorates VILI remain unclear. Therefore, we investigated whether inhaled hydrogen gas modulates the nuclear factor-kappa B (NF{kappa}B) signaling pathway. VILI was generated in male C57BL6 mice by performing a tracheostomy and placing the mice on a mechanical ventilator (tidal volume of 30 ml/kg or 10 ml/kg without positive end-expiratory pressure). The ventilator delivered either 2% nitrogen or 2% hydrogen in balanced air. NF{kappa}B activation, as indicated by NF{kappa}B DNA binding, was detected by electrophoretic mobility shift assays and enzyme-linked immunosorbent assay. Hydrogen gas inhalation increased NF{kappa}B DNA binding after 1 h of ventilation and decreased NF{kappa}B DNA binding after 2 h of ventilation, as compared with controls. The early activation of NF{kappa}B during hydrogen treatment was correlated with elevated levels of the antiapoptotic protein Bcl-2 and decreased levels of Bax. Hydrogen inhalation increased oxygen tension, decreased lung edema, and decreased the expression of proinflammatory mediators. Chemical inhibition of early NF{kappa}B activation using SN50 reversed these protective effects. NF{kappa}B activation and an associated increase in the expression of Bcl-2 may contribute, in part, to the

  7. Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation

    International Nuclear Information System (INIS)

    Huang, Chien-Sheng; Kawamura, Tomohiro; Peng, Ximei; Tochigi, Naobumi; Shigemura, Norihisa; Billiar, Timothy R.; Nakao, Atsunori; Toyoda, Yoshiya

    2011-01-01

    Highlights: → Hydrogen is a regulatory molecule with antiinflammatory and antiapoptotic protective effects. → There is very limited information on the pathways regulated in vivo by the hydrogen. → Antiapoptotic abilities of hydrogen were explained by upregulation of the antiapoptotic gene. → NFκB activation during hydrogen treatment was correlated with elevated antiapoptotic protein. → NFκB activation associated with increase Bcl-2 may contribute to cytoprotection of hydrogen. -- Abstract: We recently demonstrated the inhalation of hydrogen gas, a novel medical therapeutic gas, ameliorates ventilator-induced lung injury (VILI); however, the molecular mechanisms by which hydrogen ameliorates VILI remain unclear. Therefore, we investigated whether inhaled hydrogen gas modulates the nuclear factor-kappa B (NFκB) signaling pathway. VILI was generated in male C57BL6 mice by performing a tracheostomy and placing the mice on a mechanical ventilator (tidal volume of 30 ml/kg or 10 ml/kg without positive end-expiratory pressure). The ventilator delivered either 2% nitrogen or 2% hydrogen in balanced air. NFκB activation, as indicated by NFκB DNA binding, was detected by electrophoretic mobility shift assays and enzyme-linked immunosorbent assay. Hydrogen gas inhalation increased NFκB DNA binding after 1 h of ventilation and decreased NFκB DNA binding after 2 h of ventilation, as compared with controls. The early activation of NFκB during hydrogen treatment was correlated with elevated levels of the antiapoptotic protein Bcl-2 and decreased levels of Bax. Hydrogen inhalation increased oxygen tension, decreased lung edema, and decreased the expression of proinflammatory mediators. Chemical inhibition of early NFκB activation using SN50 reversed these protective effects. NFκB activation and an associated increase in the expression of Bcl-2 may contribute, in part, to the cytoprotective effects of hydrogen against apoptotic and inflammatory signaling pathway

  8. The effect of low level laser therapy on ventilator-induced lung injury in mice (Conference Presentation)

    Science.gov (United States)

    Szabari, Margit V.; Miller, Alyssa J.; Hariri, Lida P.; Hamblin, Michael R.; Musch, Guido; Stroh, Helene; Suter, Melissa J.

    2016-03-01

    Although mechanical ventilation (MV) is necessary to support gas exchange in critically ill patients, it can contribute to the development of lung injury and multiple organ dysfunction. It is known that high tidal volume (Vt) MV can cause ventilator-induced lung injury (VILI) in healthy lungs and increase the mortality of patients with Acute Respiratory Distress Syndrome. Low level laser therapy (LLLT) has demonstrated to have anti-inflammatory effects. We investigated whether LLLT could alleviate inflammation from injurious MV in mice. Adult mice were assigned to 2 groups: VILI+LLLT group (3 h of injurious MV: Vt=25-30 ml/kg, respiratory rate (RR)=50/min, positive end-expiratory pressure (PEEP)=0 cmH20, followed by 3 h of protective MV: Vt=9 ml/kg, RR=140/min, PEEP=2 cmH20) and VILI+no LLLT group. LLLT was applied during the first 30 min of the MV (810 nm LED system, 5 J/cm2, 1 cm above the chest). Respiratory impedance was measured in vivo with forced oscillation technique and lung mechanics were calculated by fitting the constant phase model. At the end of the MV, bronchoalveolar lavage (BAL) was performed and inflammatory cells counted. Lungs were removed en-bloc and fixed for histological evaluation. We hypothesize that LLLT can reduce lung injury and inflammation from VILI. This therapy could be translated into clinical practice, where it can potentially improve outcomes in patients requiring mechanical ventilation in the operating room or in the intensive care units.

  9. Lower tidal volume strategy (?3?ml/kg) combined with extracorporeal CO2 removal versus ?conventional? protective ventilation (6?ml/kg) in severe ARDS

    OpenAIRE

    Bein, Thomas; Weber-Carstens, Steffen; Goldmann, Anton; M?ller, Thomas; Staudinger, Thomas; Brederlau, J?rg; Muellenbach, Ralf; Dembinski, Rolf; Graf, Bernhard M.; Wewalka, Marlene; Philipp, Alois; Wernecke, Klaus-Dieter; Lubnow, Matthias; Slutsky, Arthur S.

    2013-01-01

    Background Acute respiratory distress syndrome is characterized by damage to the lung caused by various insults, including ventilation itself, and tidal hyperinflation can lead to ventilator induced lung injury (VILI). We investigated the effects of a low tidal volume (V T) strategy (V T???3?ml/kg/predicted body weight [PBW]) using pumpless extracorporeal lung assist in established ARDS. Methods Seventy-nine patients were enrolled after a ?stabilization period? (24?h with optimized therapy an...

  10. Prediction of high airway pressure using a non-linear autoregressive model of pulmonary mechanics.

    Science.gov (United States)

    Langdon, Ruby; Docherty, Paul D; Schranz, Christoph; Chase, J Geoffrey

    2017-11-02

    For mechanically ventilated patients with acute respiratory distress syndrome (ARDS), suboptimal PEEP levels can cause ventilator induced lung injury (VILI). In particular, high PEEP and high peak inspiratory pressures (PIP) can cause over distension of alveoli that is associated with VILI. However, PEEP must also be sufficient to maintain recruitment in ARDS lungs. A lung model that accurately and precisely predicts the outcome of an increase in PEEP may allow dangerous high PIP to be avoided, and reduce the incidence of VILI. Sixteen pressure-flow data sets were collected from nine mechanically ventilated ARDs patients that underwent one or more recruitment manoeuvres. A nonlinear autoregressive (NARX) model was identified on one or more adjacent PEEP steps, and extrapolated to predict PIP at 2, 4, and 6 cmH 2 O PEEP horizons. The analysis considered whether the predicted and measured PIP exceeded a threshold of 40 cmH 2 O. A direct comparison of the method was made using the first order model of pulmonary mechanics (FOM(I)). Additionally, a further, more clinically appropriate method for the FOM was tested, in which the FOM was trained on a single PEEP prior to prediction (FOM(II)). The NARX model exhibited very high sensitivity (> 0.96) in all cases, and a high specificity (> 0.88). While both FOM methods had a high specificity (> 0.96), the sensitivity was much lower, with a mean of 0.68 for FOM(I), and 0.82 for FOM(II). Clinically, false negatives are more harmful than false positives, as a high PIP may result in distension and VILI. Thus, the NARX model may be more effective than the FOM in allowing clinicians to reduce the risk of applying a PEEP that results in dangerously high airway pressures.

  11. Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice

    Directory of Open Access Journals (Sweden)

    Esther K. Wolthuis

    2012-01-01

    Full Text Available Preventing tissue-factor-(TF- mediated systemic coagulopathy improves outcome in models of sepsis. Preventing TF-mediated pulmonary coagulopathy could attenuate ventilator-induced lung injury (VILI. We investigated the effect of relative TF deficiency on pulmonary coagulopathy and inflammation in a murine model of VILI. Heterozygous TF knockout (TF+/− mice and their wild-type (TF+/+ littermates were sedated (controls or sedated, tracheotomized, and mechanically ventilated with either low or high tidal volumes for 5 hours. Mechanical ventilation resulted in pulmonary coagulopathy and inflammation, with more injury after mechanical ventilation with higher tidal volumes. Compared with TF+/+ mice, TF+/− mice demonstrated significantly lower pulmonary thrombin-antithrombin complex levels in both ventilation groups. There were, however, no differences in lung wet-to-dry ratio, BALF total protein levels, neutrophil influx, and lung histopathology scores between TF+/− and TF+/+ mice. Notably, pulmonary levels of cytokines were significantly higher in TF+/− as compared to TF+/+ mice. Systemic levels of cytokines were not altered by the relative absence of TF. TF deficiency is associated with decreased pulmonary coagulation independent of the ventilation strategy. However, relative TF deficiency does not reduce VILI and actually results in higher pulmonary levels of inflammatory mediators.

  12. Mathematics of Ventilator-induced Lung Injury.

    Science.gov (United States)

    Rahaman, Ubaidur

    2017-08-01

    Ventilator-induced lung injury (VILI) results from mechanical disruption of blood-gas barrier and consequent edema and releases of inflammatory mediators. A transpulmonary pressure (P L ) of 17 cmH 2 O increases baby lung volume to its anatomical limit, predisposing to VILI. Viscoelastic property of lung makes pulmonary mechanics time dependent so that stress (P L ) increases with respiratory rate. Alveolar inhomogeneity in acute respiratory distress syndrome acts as a stress riser, multiplying global stress at regional level experienced by baby lung. Limitation of stress (P L ) rather than strain (tidal volume [V T ]) is the safe strategy of mechanical ventilation to prevent VILI. Driving pressure is the noninvasive surrogate of lung strain, but its relations to P L is dependent on the chest wall compliance. Determinants of lung stress (V T , driving pressure, positive end-expiratory pressure, and inspiratory flow) can be quantified in terms of mechanical power, and a safe threshold can be determined, which can be used in decision-making between safe mechanical ventilation and extracorporeal lung support.

  13. Spatial distribution of sequential ventilation during mechanical ventilation of the uninjured lung: an argument for cyclical airway collapse and expansion

    Directory of Open Access Journals (Sweden)

    Altemeier William A

    2010-05-01

    Full Text Available Abstract Background Ventilator-induced lung injury (VILI is a recognized complication of mechanical ventilation. Although the specific mechanism by which mechanical ventilation causes lung injury remains an active area of study, the application of positive end expiratory pressure (PEEP reduces its severity. We have previously reported that VILI is spatially heterogeneous with the most severe injury in the dorsal-caudal lung. This regional injury heterogeneity was abolished by the application of PEEP = 8 cm H2O. We hypothesized that the spatial distribution of lung injury correlates with areas in which cyclical airway collapse and recruitment occurs. Methods To test this hypothesis, rabbits were mechanically ventilated in the supine posture, and regional ventilation distribution was measured under four conditions: tidal volumes (VT of 6 and 12 ml/kg with PEEP levels of 0 and 8 cm H2O. Results We found that relative ventilation was sequentially redistributed towards dorsal-caudal lung with increasing tidal volume. This sequential ventilation redistribution was abolished with the addition of PEEP. Conclusions These results suggest that cyclical airway collapse and recruitment is regionally heterogeneous and spatially correlated with areas most susceptible to VILI.

  14. Mechanical ventilation drives pneumococcal pneumonia into lung injury and sepsis in mice: protection by adrenomedullin.

    Science.gov (United States)

    Müller-Redetzky, Holger C; Will, Daniel; Hellwig, Katharina; Kummer, Wolfgang; Tschernig, Thomas; Pfeil, Uwe; Paddenberg, Renate; Menger, Michael D; Kershaw, Olivia; Gruber, Achim D; Weissmann, Norbert; Hippenstiel, Stefan; Suttorp, Norbert; Witzenrath, Martin

    2014-04-14

    Ventilator-induced lung injury (VILI) contributes to morbidity and mortality in acute respiratory distress syndrome (ARDS). Particularly pre-injured lungs are susceptible to VILI despite protective ventilation. In a previous study, the endogenous peptide adrenomedullin (AM) protected murine lungs from VILI. We hypothesized that mechanical ventilation (MV) contributes to lung injury and sepsis in pneumonia, and that AM may reduce lung injury and multiple organ failure in ventilated mice with pneumococcal pneumonia. We analyzed in mice the impact of MV in established pneumonia on lung injury, inflammation, bacterial burden, hemodynamics and extrapulmonary organ injury, and assessed the therapeutic potential of AM by starting treatment at intubation. In pneumococcal pneumonia, MV increased lung permeability, and worsened lung mechanics and oxygenation failure. MV dramatically increased lung and blood cytokines but not lung leukocyte counts in pneumonia. MV induced systemic leukocytopenia and liver, gut and kidney injury in mice with pneumonia. Lung and blood bacterial burden was not affected by MV pneumonia and MV increased lung AM expression, whereas receptor activity modifying protein (RAMP) 1-3 expression was increased in pneumonia and reduced by MV. Infusion of AM protected against MV-induced lung injury (66% reduction of pulmonary permeability p protect against development of lung injury, sepsis and extrapulmonary organ injury in mechanically ventilated individuals with severe pneumonia.

  15. High bias gas flows increase lung injury in the ventilated preterm lamb.

    Directory of Open Access Journals (Sweden)

    Katinka P Bach

    Full Text Available BACKGROUND: Mechanical ventilation of preterm babies increases survival but can also cause ventilator-induced lung injury (VILI, leading to the development of bronchopulmonary dysplasia (BPD. It is not known whether shear stress injury from gases flowing into the preterm lung during ventilation contributes to VILI. METHODS: Preterm lambs of 131 days' gestation (term = 147 d were ventilated for 2 hours with a bias gas flow of 8 L/min (n = 13, 18 L/min (n = 12 or 28 L/min (n = 14. Physiological parameters were measured continuously and lung injury was assessed by measuring mRNA expression of early injury response genes and by histological analysis. Control lung tissue was collected from unventilated age-matched fetuses. Data were analysed by ANOVA with a Tukey post-hoc test when appropriate. RESULTS: High bias gas flows resulted in higher ventilator pressures, shorter inflation times and decreased ventilator efficiency. The rate of rise of inspiratory gas flow was greatest, and pulmonary mRNA levels of the injury markers, EGR1 and CTGF, were highest in lambs ventilated with bias gas flows of 18 L/min. High bias gas flows resulted in increased cellular proliferation and abnormal deposition of elastin, collagen and myofibroblasts in the lung. CONCLUSIONS: High ventilator bias gas flows resulted in increased lung injury, with up-regulation of acute early response genes and increased histological lung injury. Bias gas flows may, therefore, contribute to VILI and BPD.

  16. Glutamine Attenuates Acute Lung Injury Caused by Acid Aspiration

    Directory of Open Access Journals (Sweden)

    Chih-Cheng Lai

    2014-08-01

    Full Text Available Inadequate ventilator settings may cause overwhelming inflammatory responses associated with ventilator-induced lung injury (VILI in patients with acute respiratory distress syndrome (ARDS. Here, we examined potential benefits of glutamine (GLN on a two-hit model for VILI after acid aspiration-induced lung injury in rats. Rats were intratracheally challenged with hydrochloric acid as a first hit to induce lung inflammation, then randomly received intravenous GLN or lactated Ringer’s solution (vehicle control thirty min before different ventilator strategies. Rats were then randomized to receive mechanical ventilation as a second hit with a high tidal volume (TV of 15 mL/kg and zero positive end-expiratory pressure (PEEP or a low TV of 6 mL/kg with PEEP of 5 cm H2O. We evaluated lung oxygenation, inflammation, mechanics, and histology. After ventilator use for 4 h, high TV resulted in greater lung injury physiologic and biologic indices. Compared with vehicle treated rats, GLN administration attenuated lung injury, with improved oxygenation and static compliance, and decreased respiratory elastance, lung edema, extended lung destruction (lung injury scores and lung histology, neutrophil recruitment in the lung, and cytokine production. Thus, GLN administration improved the physiologic and biologic profiles of this experimental model of VILI based on the two-hit theory.

  17. Positivismeforskrækkelse

    DEFF Research Database (Denmark)

    Holtermann, Jakob von Holderstein

    2007-01-01

    Indlægget er en replik til Jonas Christoffersens klumme "Originalt eller fri fantasi" d. 28. september der indeholder en skarp kritik af den danske retsfilosof Alf Ross. Der argumenteres for at kritikken bygger på en misforståelse af Ross retsfilosofi.......Indlægget er en replik til Jonas Christoffersens klumme "Originalt eller fri fantasi" d. 28. september der indeholder en skarp kritik af den danske retsfilosof Alf Ross. Der argumenteres for at kritikken bygger på en misforståelse af Ross retsfilosofi....

  18. Activation of the Wnt/β-catenin signaling pathway by mechanical ventilation is associated with ventilator-induced pulmonary fibrosis in healthy lungs.

    Directory of Open Access Journals (Sweden)

    Jesús Villar

    Full Text Available BACKGROUND: Mechanical ventilation (MV with high tidal volumes (V(T can cause or aggravate lung damage, so-called ventilator induced lung injury (VILI. The relationship between specific mechanical events in the lung and the cellular responses that result in VILI remains incomplete. Since activation of Wnt/β-catenin signaling has been suggested to be central to mechanisms of lung healing and fibrosis, we hypothesized that the Wnt/β-catenin signaling plays a role during VILI. METHODOLOGY/PRINCIPAL FINDINGS: Prospective, randomized, controlled animal study using adult, healthy, male Sprague-Dawley rats. Animals (n = 6/group were randomized to spontaneous breathing or two strategies of MV for 4 hours: low tidal volume (V(T (6 mL/kg or high V(T (20 mL/kg. Histological evaluation of lung tissue, measurements of WNT5A, total β-catenin, non-phospho (Ser33/37/Thr41 β-catenin, matrix metalloproteinase-7 (MMP-7, cyclin D1, vascular endothelial growth factor (VEGF, and axis inhibition protein 2 (AXIN2 protein levels by Western blot, and WNT5A, non-phospho (Ser33/37/Thr41 β-catenin, MMP-7, and AXIN2 immunohistochemical localization in the lungs were analyzed. High-V(T MV caused lung inflammation and perivascular edema with cellular infiltrates and collagen deposition. Protein levels of WNT5A, non-phospho (Ser33/37/Thr41 β-catenin, MMP-7, cyclin D1, VEGF, and AXIN2 in the lungs were increased in all ventilated animals although high-V(T MV was associated with significantly higher levels of WNT5A, non-phospho (Ser33/37/Thr41 β-catenin, MMP-7, cyclin D1, VEGF, and AXIN2 levels. CONCLUSIONS/SIGNIFICANCE: Our findings demonstrate that the Wnt/β-catenin signaling pathway is modulated very early by MV in lungs without preexistent lung disease, suggesting that activation of this pathway could play an important role in both VILI and lung repair. Modulation of this pathway might represent a therapeutic option for prevention and/or management of VILI.

  19. Role of Growth Arrest and DNA Damage–inducible α in Akt Phosphorylation and Ubiquitination after Mechanical Stress-induced Vascular Injury

    Science.gov (United States)

    Mitra, Sumegha; Sammani, Saad; Wang, Ting; Boone, David L.; Meyer, Nuala J.; Dudek, Steven M.; Moreno-Vinasco, Liliana; Garcia, Joe G. N.

    2011-01-01

    Rationale: The stress-induced growth arrest and DNA damage–inducible α (GADD45a) gene is up-regulated by mechanical stress with GADD45a knockout (GADD45a−/−) mice demonstrating both increased susceptibility to ventilator-induced lung injury (VILI) and reduced levels of the cell survival and vascular permeability signaling effector (Akt). However, the functional role of GADD45a in the pathogenesis of VILI is unknown. Objectives: We sought to define the role of GADD45a in the regulation of Akt activation induced by mechanical stress. Methods: VILI-challenged GADD45a−/− mice were administered a constitutively active Akt1 vector and injury was assessed by bronchoalveolar lavage cell counts and protein levels. Human pulmonary artery endothelial cells (EC) were exposed to 18% cyclic stretch (CS) under conditions of GADD45a silencing and used for immunoprecipitation, Western blotting or immunofluoresence. EC were also transfected with mutant ubiquitin vectors to characterize site-specific Akt ubiquitination. DNA methylation was measured using methyl-specific polymerase chain reaction assay. Measurements and Main Results: Studies exploring the linkage of GADD45a with mechanical stress and Akt regulation revealed VILI-challenged GADD45a−/− mice to have significantly reduced lung injury on overexpression of Akt1 transgene. Increased mechanical stress with 18% CS in EC induced Akt phosphorylation via E3 ligase tumor necrosis factor receptor–associated factor 6 (TRAF6)–mediated Akt K63 ubiquitination resulting in Akt trafficking and activation at the membrane. GADD45a is essential to this process because GADD45a-silenced endothelial cells and GADD45a−/− mice exhibited increased Akt K48 ubiquitination leading to proteasomal degradation. These events involve loss of ubiquitin carboxyl terminal hydrolase 1 (UCHL1), a deubiquitinating enzyme that normally removes K48 polyubiquitin chains bound to Akt thus promoting Akt K63 ubiquitination. Loss of GADD45a

  20. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. JONAS P RAMOS. Articles written in Journal of Biosciences. Volume 42 Issue 4 December 2017 pp 657-664 Article. In vitro leishmanicidal, antibacterial and antitumour potential of anhydrocochlioquinone A obtained from the fungus Cochliobolus sp. FERNANDA F CAMPOS JONAS ...

  1. Animated Dreamsi festivali parimad said eile auhinnad / Kaarel Kressa

    Index Scriptorium Estoniae

    Kressa, Kaarel, 1983-

    2010-01-01

    12. animafilmide festivali Animated Dreams grand prix' pälvis Kei Oyama film "Käeseep" (Jaapan, 2008). Parima disaini preemia sai Jonas Odelli "Tussilago" (Rootsi, 2010). Parima loo jutustas Olga ja Priit Pärna "Tuukrid vihmas" (Eesti, 2009). Teistest preemiatest

  2. Browse Title Index

    African Journals Online (AJOL)

    Items 51 - 87 of 87 ... Vol 6, No 1 (1999), Targeting Rural poverty in sub-Saharan Africa: A poverty alleviation policy framework with particular reference to Cameroon. Abstract PDF. Tchakoa Jonas, Ajaga Nji. Vol 8, No 1 (2001), Tasting the Forbidden Fruit: The Social Context of Debut Sexual Encounters Among Young Persons ...

  3. Teatribiennaal 2007, Örebro : Põgus pilguheit rootsi teatrile ja uusimale dramaturgiale / Ülev Aaloe

    Index Scriptorium Estoniae

    Aaloe, Ülev, 1944-2017-

    2007-01-01

    Rootsis Örebros mais toimunud teatrifestivali märksõnaks oli "Rootsi uuem dramaturgia". Pikemalt lavastustest: Dennis Magnussoni "Unistab surra (kõrgel positsioonil oleva rootslasena)", lavastaja Dennis Sandin, Malmö Teater Terrier. Jonas Hassen Khemiri komöödia "Invasioon", lavastaja Farnaz Arbabi, Stockholmi Linnateater

  4. Experimenting with new combinations of old ideas

    NARCIS (Netherlands)

    Linde, J.

    2012-01-01

    Many important (economic) decisions involve risk. At the same time every decision is made within a social context. So far (experimental) research studies these two aspects in isolation from each other. Jona Linde therefore combines existing experimental protocols to examine the influence of social

  5. Propaganda Art from the 20th to the 21st Century

    NARCIS (Netherlands)

    Staal, J.H.

    2018-01-01

    This study by artist Jonas Staal explores the development of propaganda art from the 20th to the 21st century. Staal defines propaganda as the performance of power by means of the equation propaganda = power + performance. Through his work as a propaganda researcher and practice as a

  6. Toward a Communication Theory Focused on Humankind's Future.

    Science.gov (United States)

    Ternent, William A.; Ternent, Janet A.

    This speech presents a model of human communication which integrates the existential philosophy of Martin Buber with the communication views of Jonas Salk. In his book, "The Survival of the Wisest," Salk characterizes an "Epoch A" to describe the values and behaviors of the past and an "Epoch B" to describe the necessary values and behaviors for…

  7. Salk therapy begins.

    Science.gov (United States)

    1996-01-01

    A clinical trial to test an immune therapy developed by polio pioneer Jonas Salk has begun enrollment of 3,000 participants, who will receive Remune shots every 12 weeks for 3 years to see if disease progression is slowed. The manufacturer is Immune Response, and the study is being conducted by the University of California at San Francisco.

  8. Aegumatu Rootsi klaas ja tundmatute disainerite kummalised ideed / Anna-Liisa Soomann

    Index Scriptorium Estoniae

    Soomann, Anna-Liisa

    2007-01-01

    Göteborgi disainipoodidest ja tuntud disaineritest nagu Josef Frank (1885-1967), Carl Malmsten (1888-1972), Bruno Mathsson (1907-1988), Jonas Bohlin (1953), Marten Claesson (1970), Eero Koivisto (1958), Ola Rune (1963), Pia Wallen (1957), Thomas Sandell (1959) ja Pia Törnell (1963)

  9. Oscillations of the static meson fields at finite baryon density

    International Nuclear Information System (INIS)

    Florkowski, W.; Friman, B.; Technische Hochschule Darmstadt

    1996-04-01

    The spatial dependence of static meson correlation functions at finite baryon density is studied in the Nambu-Jona-Lasinio model. In contrast to the finite temperature case, we find that the correlation functions at finite density are not screened but exhibit long-range oscillations. The observed phenomenon is analogous to the Friedel oscillations in a degenerate electron gas. (orig.)

  10. Military Review: Desert Shield/Desert Storm

    Science.gov (United States)

    1991-04-01

    aid station Equipment and Doctrine (BAS) provides initial medical care. This is a Physical size and personnel presence, both pa- small "tailgate...Staff Collge , Fort Jona ha Cape. 1962), 315. Leavenworti, Kansas, 16 May 1986. 6 Carver. 122 Lieutenant Colonel Thomas V. MorLey is G3 (operatios and pam

  11. On the D → K-bar*e+νe form factors

    International Nuclear Information System (INIS)

    Hussain, F.; Ivanov, A.N.; Troitskaya, N.I.

    1994-01-01

    The infinite mass effective theory, when a heavy quark mass goes to infinity, and chiral perturbation theory at the quark level, based on the extended Nambu-Jona-Lasinio model, are applied for the calculation of the D → K-bar * e + ν e decay form factors. The theoretical results agree with experimental data. (author). 16 refs

  12. Chiral symmetry restoration and pion properties in a q-deformed NJL model

    International Nuclear Information System (INIS)

    Timoteo, V.S.; Lima, C.L.

    2006-01-01

    We review the implementation of a q-deformed fermionic algebra in the Nambu-Jona-Lasinio model (NJL). The gap equations obtained from a deformed condensate as well as from the deformation of the NJL Hamiltonian are discussed. The effect of both temperature and deformation in the chiral symmetry restoration process as well as in the pion properties is studied. (author)

  13. Three Misunderstandings of Plato's Theory of Moral Education

    Science.gov (United States)

    Jonas, Mark E.

    2016-01-01

    In this essay, Mark Jonas argues that there are three broadly held misconceptions of Plato's philosophy that work against his relevance for contemporary moral education. The first is that he is an intellectualist who is concerned only with the cognitive aspect of moral development and does not sufficiently emphasize the affective and conative…

  14. Algirdas Brazauskas lubab Leedule uusi paremaid radareid / Algirdas Brazauskas ; interv. Toomas Sildam

    Index Scriptorium Estoniae

    Brazauskas, Algirdas, 1932-2010

    2005-01-01

    Leedu peaminister Algirdas Brazauskas vastab küsimustele, mis puudutavad Vene hävitaja allakukkumist Kaunase lähedal, õhujõudude juhataja kolonel Jonas Marcinkuse vabastamist ning Leedu õhuruumi turbe piisavust ja parandamise vajalikkust. Lisa: Vene hävitaja Leedus. Vt. samas: Balti riigid tahavad Schengeni leppega liituda 2007. aastal

  15. Genomewide association study to detect QTL for twinning rate in ...

    Indian Academy of Sciences (India)

    Mohsen Gholizadeh, Ghodrat Rahimi-Mianji, Ardeshir Nejati-Javaremi, Dirk Jan De Koning and Elisabeth Jonas. J. Genet. 93, 489–493. Chromosome. 02468. − log. 10. (p. ) 1. 2. 3. 4 5 6 7. 9. 11 13 15 17 19. 22 25 27. Figure 1. Manhattan plot of the results from the genomewide association analysis for twinning during the ...

  16. IPV v2.0 : upgrading the established inactivated polio vaccine production process

    NARCIS (Netherlands)

    Thomassen, Y.E.

    2014-01-01

    The first vaccine against poliovirus (PV), the causative agent of poliomyelitis, was developed in the 1950s by Jonas Salk. The vaccine (IPV) consists of an injected dose of purified and inactivated wild-type PVs (all three serotypes). Soon after this discovery, at the Rijks Instituut voor de

  17. An approach to the neck mass | Thandar | Continuing Medical ...

    African Journals Online (AJOL)

    An approach to the neck mass. MA Thandar, NE Jonas. Abstract. No Abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL ...

  18. Bosonization with inclusion of the gluon condensate

    International Nuclear Information System (INIS)

    Ebert, D.; Volkov, M.K.

    1994-01-01

    The effects of the gluon condensate on the quark condensate and on masses and coupling constants of composite mesons are discussed within a QCD-motivated Nambu-Jona-Lasinio model for zero temperature as well as for the case of finite temperature and baryon number density. (orig.)

  19. Tallinna ülikool ehitab uue Ursa maja / Mihkel Tamm

    Index Scriptorium Estoniae

    Tamm, Mihkel

    2017-01-01

    2018. a. veebruaris kavatseb Tallinna Ülikool hakata lammutama loodus- ja terviseteaduste õppehoonet ehk Ursa maja. Amortiseerunud hoone asemele ehitatakse uus, mille uksed loodetakse tudengitele avada 2019. aasta sügissemestriks. Selgitusi uue hoone kahta jagab TLÜ kantsler Peep Jonas ning kavandatava õueala kohta keskkonnakorralduse professor Helen Sooväli-Sepping

  20. Dual chiral density wave in quark matter

    International Nuclear Information System (INIS)

    Tatsumi, Toshitaka

    2002-01-01

    We prove that quark matter is unstable for forming a dual chiral density wave above a critical density, within the Nambu-Jona-Lasinio model. Presence of a dual chiral density wave leads to a uniform ferromagnetism in quark matter. A similarity with the spin density wave theory in electron gas and the pion condensation theory is also pointed out. (author)

  1. 77 FR 25538 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate

    Science.gov (United States)

    2012-04-30

    ... ERIK PAUL FURLER NICOLAS SILVAN FURRER GAJA MARIA FURRER JONAS KEVIN FURRER SACHA GABRIELLA GAGNON... CATHERINE MARIE MILNE NATASHA JANE MIN CHRIS SHIK MIN STEVE BAE MIZRACHI ELI HAIM MONTAGUE ALEXANDRE NICOLAS... CHRISTIAN MARTIN SYZ ISABEL SUSAN TAN CHUAN LIONG TAN WEI-EE BEVERLY [[Page 25544

  2. 2018-05-05T21:20:14Z https://www.ajol.info/index.php/all/oai oai:ojs ...

    African Journals Online (AJOL)

    article/37925 2018-05-05T21:20:14Z cajeb:ART Macrophyte diversity in polluted and non-polluted wetlands in Cameroon Fonkou, Théophile; BP 377 Dschang, Cameroon Nguetsop, Victor F Pinta, Jonas Y Dekoum, Vincent MA Lekeufack, Martin ...

  3. Leedu kunst on integratsioonivõimeline / Eha Komissarov

    Index Scriptorium Estoniae

    Komissarov, Eha, 1947-

    2004-01-01

    Leedu kaasaegse kunsti näitus "Omas mahlas" Tallinna Kunstihoones (Evaldas Jansas, Egle Rakauskaite) ja Rotermanni soolalaos (Loreta Bilinskaite-Burke, Laura Barbshtiene & Arturas Bumshteinas (G-Lab), Jonas Gasiunas, Arunas Gudaitis, Linas Jablonskis, Dainius Lishkevicius, Mindaugas Lukoshaitis, Gintaras Makarevicius, Deimantas Narkevicius, Egle Ridikaite, Irma Stanaityte, Laura Stasiulyte, Mindaugas Shimkus, Arturas Valiauga, Rimaldas Vikshraitis, Darius Zhiura). Kuraator Anders Kreuger leedu kunstniku kuvandiloomest

  4. Wilson Fermions with Four Fermion Interactions

    DEFF Research Database (Denmark)

    Rantaharju, Jarno; Drach, Vincent; Hietanen, Ari

    2015-01-01

    We present a lattice study of a four fermion theory, known as Nambu Jona-Lasinio (NJL) theory, via Wilson fermions. Four fermion interactions naturally occur in several extensions of the Standard Model as a low energy parameterisation of a more fundamental theory. In models of dynamical electroweak...

  5. Microstructures and properties of low-alloy fire resistant steel

    Indian Academy of Sciences (India)

    Unknown

    hardening. In a quenched and self-tempered 600 MPa class TMT reinforcement bar steel (YS: 624 MPa), low ..... of processing (1000–1050°C), static, dynamic as well as metadynamic recrystallization of austenite can occur (Poliak and Jonas ...

  6. Report on the state of play for the implementation of the project Integrated Baltic Offshore Wind Electricity Grid Development (Baltic InteGrid) of the Seed Money Facility of the European Union Strategy for the Baltic Sea Region (EUSBSR Seed Money Facility)

    DEFF Research Database (Denmark)

    Wojcik, Mariusz; Proba, Gert; Kruse, Dennis

    2014-01-01

    Mariusz Wójcik, Foundation for Sustainable Energy, PolandGert Proba, Rostock Business and Technology Development, GermanyDennis Kruse, Stephanie Wehkamp, German Offshore Wind Energy FoundationLennart Tyrberg, Energy Agency for Southeast SwedenJonas Katz, Poul Ejnar Sørensen...

  7. Maailmakogemus dokumentaalfilmis / Andri Ksenofontov

    Index Scriptorium Estoniae

    Ksenofontov, Andri, 1962-

    2009-01-01

    Leedu päritolu USA alternatiivkino klassikust Jonas Mekasest ja tema loomingust, mida tutvustati Kumu auditooriumis Fluxuse filmiprogrammi raames. Soome kunstnikust Seppo Renvallist ning tema video- ja filmiloomingust. Kumu auditooriumis 21. 10. 2009 näidatud dokumentaalfilmist "Elav jumalanna" (Nepal/ Suurbritannia), režissöör Ishbel Whitaker, operaator Marc Hawker

  8. Valmib valus lavalugu perest : Athenas jõuab vaatajate ette Mart Kivastiku suhtedraama / Raimu Hanson

    Index Scriptorium Estoniae

    Hanson, Raimu, 1957-

    2008-01-01

    SA Eesti Teatri Festival esietendab 4. mail Athena keskuses Margus Kasterpalu lavastuses Mart Kivastiku näidendit "Meie isa, kes sa oled ..." Mängivad Vanemuise näitlejad Marika Aidla, Hannes Kaljujärv, Tanel Jonas ning Leino Rei

  9. Dynamical Symmetry Breaking of Maximally Generalized Yang-Mills Model and Its Restoration at Finite Temperatures

    International Nuclear Information System (INIS)

    Wang Dianfu

    2008-01-01

    In terms of the Nambu-Jona-Lasinio mechanism, dynamical breaking of gauge symmetry for the maximally generalized Yang-Mills model is investigated. The gauge symmetry behavior at finite temperature is also investigated and it is shown that the gauge symmetry broken dynamically at zero temperature can be restored at finite temperatures

  10. Fluxuse "tagasitulek" Leetu = The "return" of Fluxus to Lithuania / Petra Stegmann ; interv. Skaidra Trilupaityte

    Index Scriptorium Estoniae

    Stegmann, Petra

    2008-01-01

    Näitus "Fluxus East. Fluxuse võrgustikud Ida-Euroopas" Kumu Kunstimuuseumis, kuraator Petra Stegmann. Fluxuse liikumisest leedu kunstniku Yurgis George Maciunase eestvedamisel. Rühmituse ideoloogiast, liikmete tegevusest. Vilniuses asutatud Jonas Mekase Visuaalkunsti Keskuse poolt omandatud leedu kunstnike töödest, nende uurimisest

  11. Phronesis and an ethics of responsibility | van Niekerk | South ...

    African Journals Online (AJOL)

    This approach is the ethics of responsibility, as inspired by the work of Emmanuel Levinas, Zygmunt Bauman and Hans Jonas. The two central ideas of this approach are (i) the ethics of responsibility as an approach that accommodates the possibility of failure; and (ii) that the ethics of responsibility suggests the need for a ...

  12. Notes on the ecology and status of some forest mammals in four ...

    African Journals Online (AJOL)

    Notes on the ecology and status of some forest mammals in four Eastern Arc Mountains, Tanzania. Norbert J Cordeiro, Nathalie Seddon, David R Capper, Jonathan MM Ekstrom, Kim M Howell, Isabel S Isherwood, Charles AM Msuya, Jonas T Mushi, Andrew W Perkin, Robert G Pople, William T Stanley ...

  13. Comment on critical instability

    International Nuclear Information System (INIS)

    King, S.F.; Suzuki, Mahiko

    1992-01-01

    We discuss the problem of the mass splitting between top and bottom quarks, within the context of Nambu-Jona-Lasinio type models involving top and bottom quark condensates. We interpret the phenomenon of 'critical instability' recently proposed to account for such a mass splitting as the fine-tuning of two vacuum expectation values in a composite two-Higgs doublet model. (orig.)

  14. 2005 Tri-Service Infrastructure Systems Conference and Exhibition. Volume 1, Track 1

    Science.gov (United States)

    2005-08-04

    Alan Tool Sediment Impact Assessment Model (SIAM), by David S. Biedenharn and Meg Jonas Mississippi River Sedimentation Study, by Basil Arthur Sediment...Questionnaire Client Report Reports Criteria/Lesson Learned Project Details PRO JEC TS DAT ABA SE 9 eProjects 1. Business Line CIBL Program ANY MILCON 2

  15. Spin-polarized versus chiral condensate in quark matter at finite temperature and density

    DEFF Research Database (Denmark)

    Matsuoka, Hiroaki; Tsue, Yasuhiko; da Providencia, Joao

    2016-01-01

    It is shown that the spin-polarized condensate appears in quark matter at high baryon density and low temperature due to the tensor-type four-point interaction in the Nambu-Jona-Lasiniotype model as a low-energy effective theory of quantum chromodynamics. It is indicated within this low-energy ef...

  16. Spin polarization in high density quark matter under a strong external magnetic field

    DEFF Research Database (Denmark)

    Tsue, Yasuhiko; Da Providência, João; Providência, Constança

    2016-01-01

    In high density quark matter under a strong external magnetic field, possible phases are investigated by using the two-flavor Nambu-Jona-Lasinio (NJL) model with tensor-type four-point interaction between quarks, as well as the axial-vector-type four-point interaction. In the tensor-type interact...

  17. Spin polarization versus color–flavor locking in high-density quark matter

    DEFF Research Database (Denmark)

    Tsue, Yasuhiko; da Providência, João; Providência, Constança

    2015-01-01

    It is shown that spin polarization with respect to each flavor in three-flavor quark matter occurs instead of color–flavor locking at high baryon density by using the Nambu–Jona-Lasinio model with four-point tensor-type interaction. Also, it is indicated that the order of phase transition between...

  18. International recognition for ageing research: John Scott Award-2014 to Leonard Hayflick and Paul Moorhead

    DEFF Research Database (Denmark)

    Rattan, Suresh

    2014-01-01

    is the oldest scientific award in the United States and, as a legacy to Benjamin Franklin, they are in the historic company of past winners who include Marie Curie, Thomas Edison, Jonas Salk, Irving Langmuir, Nicola Tesla, Guglielmo Marconi, R. Buckminister Fuller, Sir Alexander Fleming, Sir Howard Florey...

  19. Tidal volume in acute respiratory distress syndrome: how best to select it.

    Science.gov (United States)

    Umbrello, Michele; Marino, Antonella; Chiumello, Davide

    2017-07-01

    Mechanical ventilation is the type of organ support most widely provided in the intensive care unit. However, this form of support does not constitute a cure for acute respiratory distress syndrome (ARDS), as it mainly works by buying time for the lungs to heal while contributing to the maintenance of vital gas exchange. Moreover, it can further damage the lung, leading to the development of a particular form of lung injury named ventilator-induced lung injury (VILI). Experimental evidence accumulated over the last 30 years highlighted the factors associated with an injurious form of mechanical ventilation. The present paper illustrates the physiological effects of delivering a tidal volume to the lungs of patients with ARDS, and suggests an approach to tidal volume selection. The relationship between tidal volume and the development of VILI, the so called volotrauma, will be reviewed. The still actual suggestion of a lung-protective ventilatory strategy based on the use of low tidal volumes scaled to the predicted body weight (PBW) will be presented, together with newer strategies such as the use of airway driving pressure as a surrogate for the amount of ventilatable lung tissue or the concept of strain, i.e., the ratio between the tidal volume delivered relative to the resting condition, that is the functional residual capacity (FRC). An ultra-low tidal volume strategy with the use of extracorporeal carbon dioxide removal (ECCO 2 R) will be presented and discussed. Eventually, the role of other ventilator-related parameters in the generation of VILI will be considered (namely, plateau pressure, airway driving pressure, respiratory rate (RR), inspiratory flow), and the promising unifying framework of mechanical power will be presented.

  20. Early biomarkers and potential mediators of ventilation-induced lung injury in very preterm lambs

    Directory of Open Access Journals (Sweden)

    Davis Peter G

    2009-03-01

    Full Text Available Abstract Background Bronchopulmonary dysplasia (BPD is closely associated with ventilator-induced lung injury (VILI in very preterm infants. The greatest risk of VILI may be in the immediate period after birth, when the lungs are surfactant deficient, still partially filled with liquid and not uniformly aerated. However, there have been very few studies that have examined this immediate post-birth period and identified the initial injury-related pathways that are activated. We aimed to determine if the early response genes; connective tissue growth factor (CTGF, cysteine rich-61 (CYR61 and early growth response 1 (EGR1, were rapidly induced by VILI in preterm lambs and whether ventilation with different tidal volumes caused different inflammatory cytokine and early response gene expression. Methods To identify early markers of VILI, preterm lambs (132 d gestational age; GA, term ~147 d were resuscitated with an injurious ventilation strategy (VT 20 mL/kg for 15 min then gently ventilated (5 mL/kg for 15, 30, 60 or 120 min (n = 4 in each. To determine if early response genes and inflammatory cytokines were differentially regulated by different ventilation strategies, separate groups of preterm lambs (125 d GA; n = 5 in each were ventilated from birth with a VT of 5 (VG5 or 10 mL/kg (VG10 for 135 minutes. Lung gene expression levels were compared to levels prior to ventilation in age-matched control fetuses. Results CTGF, CYR61 and EGR1 lung mRNA levels were increased ~25, 50 and 120-fold respectively (p CTGF, CYR61, EGR1, IL1-β, IL-6 and IL-8 mRNA levels compared to control levels. CTGF, CYR61, IL-6 and IL-8 expression levels were higher in VG10 than VG5 lambs; although only the IL-6 and CYR61 mRNA levels reached significance. Conclusion CTGF, CYR61 and EGR1 may be novel early markers of lung injury and mechanical ventilation from birth using relatively low tidal volumes may be less injurious than using higher tidal volumes.

  1. El incremento de responsabilidad en la ética medioambiental

    Directory of Open Access Journals (Sweden)

    J. Ma. Ga. Gómez-Heras

    2012-03-01

    Full Text Available El presente articulo tiene como objetivo fundamental abordar el concepto de responsabilidad en el ámbito de la ética aplicada medioambiental. Para llevar a cabo esta tarea se analiza el pensamiento teleológico de Hans Jonas para una concepción medioambiental de la responsabilidad situando dicho planteamiento en discusión con las éticas deontológicas o de la convicción.The main aim of this paper is to address the concept of responsibility in the area of applied environmental ethics. To this end, we analyse the teleologic thought of Hans Jonas for an environmental conception of responsibility and situate this approach in discussion with deontological ethics or of conviction.

  2. Portrait

    Science.gov (United States)

    Granoff, Dan M.

    2013-01-01

    Born in 1944, I grew up in a world in which polio was both a gripping fear and real threat. Then in a matter of a few years—polio was eradicated by a vaccine developed by Jonas Salk. Later I learned that Salk’s efforts were built on pioneering work of many others, including John Enders, Thomas Weller and Frederick Robbins (Nobelists, 1954), and David Bodian, who pioneered studies of polio pathogenesis and immunity. Bodian became my teacher in medical school, and Robbins became a colleague. Later, Salk, Robbins and I shared a platform at an infectious diseases symposium, and I was privileged to speak at Robbins’ retirement. But that gets ahead of my story. In January 1956, at age 12 y, I received my first of dose of the “Salk” vaccine. Other kids had pictures of athletes in their rooms; I had a picture of Jonas Salk. PMID:23807081

  3. Portrait: coincidences, convergences and opportunities.

    Science.gov (United States)

    Granoff, Dan M

    2013-05-01

    Born in 1944, I grew up in a world in which polio was both a gripping fear and real threat. Then in a matter of a few years-polio was eradicated by a vaccine developed by Jonas Salk. Later I learned that Salk's efforts were built on pioneering work of many others, including John Enders, Thomas Weller and Frederick Robbins (Nobelists, 1954), and David Bodian, who pioneered studies of polio pathogenesis and immunity. Bodian became my teacher in medical school, and Robbins became a colleague. Later, Salk, Robbins and I shared a platform at an infectious diseases symposium, and I was privileged to speak at Robbins' retirement. But that gets ahead of my story. In January 1956, at age 12 y, I received my first of dose of the "Salk" vaccine. Other kids had pictures of athletes in their rooms; I had a picture of Jonas Salk.

  4. Dynamics of inhomogeneous chiral condensates

    Science.gov (United States)

    Carlomagno, Juan Pablo; Krein, Gastão; Kroff, Daniel; Peixoto, Thiago

    2018-01-01

    We study the dynamics of the formation of inhomogeneous chirally broken phases in the final stages of a heavy-ion collision, with particular interest on the time scales involved in the formation process. The study is conducted within the framework of a Ginzburg-Landau time evolution, driven by a free energy functional motivated by the Nambu-Jona-Lasinio model. Expansion of the medium is modeled by one-dimensional Bjorken flow and its effect on the formation of inhomogeneous condensates is investigated. We also use a free energy functional from a nonlocal Nambu-Jona-Lasinio model which predicts metastable phases that lead to long-lived inhomogeneous condensates before reaching an equilibrium phase with homogeneous condensates.

  5. Precautionary discourse. Thinking through the distinction between the precautionary principle and the precautionary approach in theory and practice.

    Science.gov (United States)

    Dinneen, Nathan

    2013-01-01

    This paper addresses the distinction, arising from the different ways the European Union and United States have come to adopt precaution regarding various environmental and health-related risks, between the precautionary principle and the precautionary approach in both theory and practice. First, this paper addresses how the precautionary principle has been variously defined, along with an exploration of some of the concepts with which it has been associated. Next, it addresses how the distinction between the precautionary principle and precautionary approach manifested itself within the political realm. Last, it considers the theoretical foundation of the precautionary principle in the philosophy of Hans Jonas, considering whether the principled-pragmatic distinction regarding precaution does or doesn't hold up in Jonas' thought.

  6. Virtualaus finansų rinkos modelio programinis realizavimas ir tyrimas

    OpenAIRE

    Haidari, Ališer Antony

    2011-01-01

    A simple Stock Exchange Game Model (SEGM) was introduced in 2009 by prof. Jonas Mockus to simulate the behavior of several stockholders using fixed buying-selling margins at fixed bank yield. The new model, Extended Stock Exchange model (USEGM), is under development, which advantage is application of the Nash Equilibrium (NE) to strategies that define buying-selling margins and bank haircuts (HC) dynamically. In addition, USEGM includes the transaction costs to reflect the reality better. Thi...

  7. Constituent quarks in nuclear matter and the Nolen-Schiffer anomaly

    International Nuclear Information System (INIS)

    Lutz, M.; Lee, H.K.; Weise, W.

    1991-01-01

    We investigate the density dependence of the neutron-proton mass difference using the Nambu and Jona-Lasinio model in combination with the Isgur-Karl constituent quark model. The decrease of the constituent quark masses with increasing density reduces the n-p mass difference in the proper way to help resolving the Nolen-Schiffer anomaly. We point out however, that in the presence of vector interactions, this effect is less pronounced than previously suggested. (orig.)

  8. Ethical decision making

    OpenAIRE

    Zsolnai, László

    2011-01-01

    The self-centeredness of modern organizations leads to environmental destruction and human deprivation. The principle of responsibility developed by Hans Jonas requires caring for the beings affected by our decisions and actions. Ethical decision-making creates a synthesis of reverence for ethical norms, rationality in goal achievement, and respect for the stakeholders. The maximin rule selects the "least worst alternative" in the multidimensional decision space of deontologica...

  9. Vaccines today, vaccines tomorrow: a perspective

    OpenAIRE

    Loucq, Christian

    2013-01-01

    Vaccines are considered as one of the major contributions of the 20th century and one of the most cost effective public health interventions. The International Vaccine Institute has as a mission to discover, develop and deliver new and improved vaccines against infectious diseases that affects developing nations. If Louis Pasteur is known across the globe, vaccinologists like Maurice Hilleman, Jonas Salk and Charles M?rieux are known among experts only despite their contribution to global hea...

  10. Current status of poliovirus infections.

    OpenAIRE

    Melnick, J L

    1996-01-01

    Two scientists who played leading roles in the conquest of poliomyelitis died recently. In 1954, Jonas Salk provided the first licensed polio vaccine, the formalin (and heat)-inactivated virus. Albert Sabin gave us the attenuated live virus vaccine, which was licensed in 1962. This paper takes the reader through the history of the disease, including its pathogenesis, epidemiology, vaccines, and future directions. The emphasis is on vaccines, for it seems that with proper vaccination the numbe...

  11. Relativistic Many-Body Hamiltonian Approach to Mesons

    OpenAIRE

    Llanes-Estrada, Felipe J.; Cotanch, Stephen R.

    2001-01-01

    We represent QCD at the hadronic scale by means of an effective Hamiltonian, $H$, formulated in the Coulomb gauge. As in the Nambu-Jona-Lasinio model, chiral symmetry is explicity broken, however our approach is renormalizable and also includes confinement through a linear potential with slope specified by lattice gauge theory. This interaction generates an infrared integrable singularity and we detail the computationally intensive procedure necessary for numerical solution. We focus upon app...

  12. Chiral symmetry breaking in d=3 NJL model in external gravitational and magnetic fields

    OpenAIRE

    Gitman, D. M.; Odintsov, S. D.; Shil'nov, Yu. I.

    1996-01-01

    The phase structure of $d=3$ Nambu-Jona-Lasinio model in curved spacetime with magnetic field is investigated in the leading order of the $1/N$-expansion and in linear curvature approximation (an external magnetic field is treated exactly). The possibility of the chiral symmetry breaking under the combined action of the external gravitational and magnetic fields is shown explicitly. At some circumstances the chiral symmetry may be restored due to the compensation of the magnetic field by the ...

  13. A royal visit : King Harald V and Queen Sonja of Norway made a trip to CERN on Tuesday 4 April

    CERN Multimedia

    Maximilien Brice

    2006-01-01

    CERN Director-General Robert Aymar welcomed the royal party, which included the Norwegian Minister of Foreign Affairs, Jonas Gahr Støre, and provided an overview of CERN's history and current and future research. ATLAS deputy spokesperson Steinar Stapnes then quickly explained the concept and inner workings of the LHC, some LHC physics goals and ATLAS, which is one of the main experiments receiving Norwegian contributions

  14. An Effective Chiral Meson Lagrangian at O(p6) from the NJL Model

    International Nuclear Information System (INIS)

    Bel'kov, A.A.; Lanev, A.V.; Schaale, A.; Scherer, S.; Mainz Univ.

    1994-01-01

    In this work we present a strong chiral meson Lagrangian up to and including O(p 6 ) in the momentum expansion. It is derived from the Nambu-Jona-Lasinio (NJL) model using the heat-kernel method. Identities related to the properties of covariant derivatives of the chiral matrix U as well as field transformations have been used to predict the chiral coefficients of a minimal set of linearly independent terms. 16 refs

  15. How neutron stars constrain the nuclear equation of state

    Directory of Open Access Journals (Sweden)

    Hell Thomas

    2014-03-01

    Full Text Available Recent neutron star observations set new constraints for the equation of state of baryonic matter. A chiral effective field theory approach is used for the description of neutron-dominated nuclear matter present in the outer core of neutron stars. Possible hybrid stars with quark matter in the inner core are discussed using a three-flavor Nambu–Jona-Lasinio model.

  16. Prescription medicine sharing experience among pharmacy students

    OpenAIRE

    Šliogerytė, Karolina

    2017-01-01

    K.Šliogeryte`s master thesis. Master thesis supervisor associate professor Jonas Grincevičius (2015/2016), lecturer J. Daukšienė(2016/2017); Lithuanian University of Health Sciences, Faculty of Pharmacy, Pharmaceutical technology and Social pharmacy department. – Kaunas. Master thesis: prescription medicine sharing experience among pharmacy students. The aim: to evaluate LUHS Pharmacy faculty students` experience in prescription drugs` sharing. Methods: empirical qualitative method...

  17. Training preferences and motivation for rehabilitation in patients with neck pain

    OpenAIRE

    Verbrugghe, Jonas; Cuyvers, Bert

    2014-01-01

    MP2 scientific research "Training preferences and motivation for rehabilitation in patients with neck pain" by Bert Cuyvers & Jonas Verbrugghe Aim: The aim of this investigation is the inventory of training preferences and motives for motor rehabilitation of patients with neck pain. The second aim of this study is to evaluate to which extent patients with neck pain are familiar with the use of technologies. Methods: Semi-structured interviews were conducted based on the Neck Disa...

  18. Quark confinement in a constituent quark model

    International Nuclear Information System (INIS)

    Langfeld, K.; Rho, M.

    1995-01-01

    On the level of an effective quark theory, we define confinement by the absence of quark anti-quark thresholds in correlation function. We then propose a confining Nambu-Jona-Lasinio-type model. The confinement is implemented in analogy to Anderson localization in condensed matter systems. We study the model's phase structure as well as its behavior under extreme conditions, i.e. high temperature and/or high density

  19. Baryons as solitonic solutions of the chiral sigma model

    International Nuclear Information System (INIS)

    Bentz, W.; Hartmann, J.; Beck, F.

    1996-01-01

    Self-consistent solitonic solutions with baryon number one are obtained in the chiral quark sigma model. The translational invariant vacuum is stabilized by a Landau ghost subtraction procedure based on the requirement of the Kaellacute en-Lehmann (KL) representation for the meson propagators. The connection of this ghost free model (KL model) to the more popular Nambu-Jona-Lasinio (NJL) model is discussed in detail. copyright 1996 The American Physical Society

  20. Nucleon quark distributions in a covariant quark-diquark model

    Energy Technology Data Exchange (ETDEWEB)

    Cloet, I.C. [Special Research Centre for the Subatomic Structure of Matter and Department of Physics and Mathematical Physics, University of Adelaide, SA 5005 (Australia) and Jefferson Lab, 12000 Jefferson Avenue, Newport News, VA 23606 (United States)]. E-mail: icloet@physics.adelaide.edu.au; Bentz, W. [Department of Physics, School of Science, Tokai University, Hiratsuka-shi, Kanagawa 259-1292 (Japan)]. E-mail: bentz@keyaki.cc.u-tokai.ac.jp; Thomas, A.W. [Jefferson Lab, 12000 Jefferson Avenue, Newport News, VA 23606 (United States)]. E-mail: awthomas@jlab.org

    2005-08-18

    Spin-dependent and spin-independent quark light-cone momentum distributions and structure functions are calculated for the nucleon. We utilize a modified Nambu-Jona-Lasinio model in which confinement is simulated by eliminating unphysical thresholds for nucleon decay into quarks. The nucleon bound state is obtained by solving the Faddeev equation in the quark-diquark approximation, where both scalar and axial-vector diquark channels are included. We find excellent agreement between our model results and empirical data.

  1. Polarized quark distributions in bound nucleon and polarized EMC effect in Thermodynamical Bag Model

    Energy Technology Data Exchange (ETDEWEB)

    Ganesamurthy, Kuppusamy, E-mail: udckgm@sify.co [Research Department of Physics, Urumu Dhanalakshmi College, Trichy 620019 (India); Sambasivam, Raghavan, E-mail: udcsam@sify.co [Research Department of Physics, Urumu Dhanalakshmi College, Trichy 620019 (India)

    2011-04-15

    The polarized parton distribution functions (PDFs) and nuclear structure functions are evaluated by the phenomenological Thermodynamical Bag Model for nuclear media {sup 7}Li and {sup 27}Al. The Fermi statistical distribution function which includes the spin degree of freedom is used in this statistical model. We predict a sizeable polarized EMC effect. The results of quark spin sum and axial coupling constant of bound nucleons are compared with theoretical predictions of modified Nambu-Jona-Lasinio (NJL) model by Bentz et al.

  2. The phases of isospin-asymmetric matter in the two-flavor NJL model

    Energy Technology Data Exchange (ETDEWEB)

    Lawley, S. [Special Research Centre for the Subatomic Structure of Matter, University of Adelaide, Adelaide, SA 5005 (Australia) and Jefferson Lab, 12000 Jefferson Avenue, Newport News, VA 23606 (United States)]. E-mail: slawley@jlab.org; Bentz, W. [Department of Physics, School of Science, Tokai University, Hiratsuka-shi, Kanagawa 259-1292 (Japan); Thomas, A.W. [Jefferson Lab, 12000 Jefferson Avenue, Newport News, VA 23606 (United States)

    2006-01-19

    We investigate the phase diagram of isospin-asymmetric matter at T=0 in the two-flavor Nambu-Jona-Lasinio model. Our approach describes the single nucleon as a confined quark-diquark state, the saturation properties of nuclear matter at normal densities, and the phase transition to normal or color superconducting quark matter at higher densities. The resulting equation of state of charge-neutral matter and the structure of compact stars are discussed.

  3. Relativistic Faddeev description of baryons and nucleon structure function in the NJL model

    Energy Technology Data Exchange (ETDEWEB)

    Bentz, W.; Mineo, H.; Asami, H.; Yazaki, K

    2000-05-08

    In this work we use the Nambu-Jona-Lasinio (NJL) model as an effective quark theory based on QCD to describe the structure of baryons. Based on the solutions of the relativistic 3-quark Faddeev equation in the ladder approximation, we discuss the masses of the nucleon and the delta, the static properties of the nucleon, and the quark light cone momentum distributions in the nucleon.

  4. Phase transition from nuclear matter to color superconducting quark matter

    Energy Technology Data Exchange (ETDEWEB)

    Bentz, W. E-mail: bentz@keyaki.cc.u-tokai.ac.jp; Horikawa, T.; Ishii, N.; Thomas, A.W

    2003-06-02

    We construct the nuclear and quark matter equations of state at zero temperature in an effective quark theory (the Nambu-Jona-Lasinio model), and discuss the phase transition between them. The nuclear matter equation of state is based on the quark-diquark description of the single nucleon, while the quark matter equation of state includes the effects of scalar diquark condensation (color superconductivity). The effect of diquark condensation on the phase transition is discussed in detail.

  5. The sites and mechanisms of postoperative insulin resistance

    OpenAIRE

    Nygren, Jonas

    1997-01-01

    The Sites and Mechanisms of Postoperative InsulinResistance by Jonas Nygren, M.D. Departments of Surgery and Endocrinology and Diabetes, Karolinska Hospital and Institute, SE-171 76, Stockholm, Sweden In Sweden with nine million inhabitants, 450,000 operations(outpatients excluded) are performed every year resulting in2,250,000 treatment days in hospital. Surgical operations are part ofthe treatment for 44% of all patients admitted to hospital careoccupying 24% of all ...

  6. Dynamical CP violation of the generalized Yang-Mills model

    International Nuclear Information System (INIS)

    Wang Dianfu; Chang Xiaojing; Sun Xiaoyu

    2011-01-01

    Starting from the generalized Yang-Mills model which contains, besides the vector part V μ , also a scalar part S and a pseudoscalar part P . It is shown, in terms of the Nambu-Jona-Lasinio (NJL) mechanism, that CP violation can be realized dynamically. The combination of the generalized Yang-Mills model and the NJL mechanism provides a new way to explain CP violation. (authors)

  7. Spin polarization in high density quark matter

    DEFF Research Database (Denmark)

    Bohr, Henrik; Panda, Prafulla K.; Providênci, Constanca

    2013-01-01

    We investigate the occurrence of a ferromagnetic phase transition in high density hadronic matter (e.g., in the interior of a neutron star). This could be induced by a four-fermion interaction analogous to the one which is responsible for chiral symmetry breaking in the Nambu-Jona-Lasinio model, ...... the so-called 2 flavor super-conducting phase to the ferromagnetic phase arises. The color-flavor-locked phase may be completely hidden by the FP....

  8. QCD bound states at finite temperature and baryon number

    International Nuclear Information System (INIS)

    Kalinovsky, Yu.L.; Muenchow, L.

    1991-04-01

    Quark-antiquark bound states are described within the Bethe-Salpeter equation for a class of quark models with instantaneous 4-quark interaction at finite temperature. Thereby decompositions of the Bethe-Salpeter vertex and wave functions according to their Lorentz structures and the particles content are used. As an application of general scheme, we determine the mass spectrum of low-lying mesons for a special Nambu-Jona-Lasinio model inspired by QCD for hadrons. (orig.)

  9. Oscillations of the static meson fields at finite baryon density

    International Nuclear Information System (INIS)

    Florkowski, W.; Friman, B.; Technische Hochschule Darmstadt

    1996-04-01

    The spatial dependence of static meson correlation functions at finite baryon density is studied in the Nambu-Jona-Lasinio model. In contrast to the finite temperature case, we find that the correlation functions at finite density are not screened but exhibit long-range oscillations. The observed phenomenon is analogous to the Friedel oscillations in a degenerate electron gas. (author). 19 refs, 6 figs

  10. Texture Development in Friction Stir Welds

    Science.gov (United States)

    2011-01-01

    and J. J. Jonas: Acta Metall., 1989, 37, (8), 2197–2210. 17. S. Li, I. J. Beyerlein and M. A. M. Bourke : Mater. Sci. Eng. A, 2005, A394, (1–2), 66–77...M. Bourke , D. Brown, B. Clausen, C. Tome, R. V. Dreele, C. Xu and T. Langdon: Mater. Sci. Forum, 2003, 426–432, 2661–2666. 26. J. A. Schneider and A

  11. Chiral symmetry and the charge asymmetry of the s bar s distribution in a proton

    International Nuclear Information System (INIS)

    Burkardt, M.

    1991-05-01

    Based on a simple K-cloud model, as well as the Gross-Neveu and the Nambu-Jona-Lasinio model, it is predicted that the s bar s sea in a proton is not charge symmetric at large Bjorken-x. The s quarks are shifted to larger values of x bj than the bar s quarks. Furthermore these large x bj s quarks carry a negative polarization. 9 refs., 2 figs

  12. Muusika / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2004-01-01

    Mihkel Pollpälvis XVIII Rina Sala Gallo rahvusvahelisel pianistide konkursil esikoha. Igal reedel hakkavad toimuma Vanalinnastuudio väikeses saalis jazziklubi-kontserdid. Vanemuise teatri menumuusikalis "Viiuldaja katusel" astusid esmakordselt vaatajate ette uued osatäitjad. Ardo-Ran Varres ja Tanel Jonas. Pärdil uus teos "Da pacem domine". 28.- 31. X toimuvad Nõmme muusikakoolis üleriigilised klaveriõpetajate päevad

  13. Patients with uninjured lungs may also benefit from lung-protective ventilator settings [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Roger Alencar

    2017-11-01

    Full Text Available Although mechanical ventilation is a life-saving strategy in critically ill patients and an indispensable tool in patients under general anesthesia for surgery, it also acts as a double-edged sword. Indeed, ventilation is increasingly recognized as a potentially dangerous intrusion that has the potential to harm lungs, in a condition known as ‘ventilator-induced lung injury’ (VILI. So-called ‘lung-protective’ ventilator settings aiming at prevention of VILI have been shown to improve outcomes in patients with acute respiratory distress syndrome (ARDS, and, over the last few years, there has been increasing interest in possible benefit of lung-protective ventilation in patients under ventilation for reasons other than ARDS. Patients without ARDS could benefit from tidal volume reduction during mechanical ventilation. However, it is uncertain whether higher levels of positive end-expiratory pressure could benefit these patients as well. Finally, recent evidence suggests that patients without ARDS should receive low driving pressures during ventilation.

  14. Image processing and machine learning techniques to automate diagnosis of Lugol's iodine cervigrams for a low-cost point-of-care digital colposcope

    Science.gov (United States)

    Asiedu, Mercy Nyamewaa; Simhal, Anish; Lam, Christopher T.; Mueller, Jenna; Chaudhary, Usamah; Schmitt, John W.; Sapiro, Guillermo; Ramanujam, Nimmi

    2018-02-01

    The world health organization recommends visual inspection with acetic acid (VIA) and/or Lugol's Iodine (VILI) for cervical cancer screening in low-resource settings. Human interpretation of diagnostic indicators for visual inspection is qualitative, subjective, and has high inter-observer discordance, which could lead both to adverse outcomes for the patient and unnecessary follow-ups. In this work, we a simple method for automatic feature extraction and classification for Lugol's Iodine cervigrams acquired with a low-cost, miniature, digital colposcope. Algorithms to preprocess expert physician-labelled cervigrams and to extract simple but powerful color-based features are introduced. The features are used to train a support vector machine model to classify cervigrams based on expert physician labels. The selected framework achieved a sensitivity, specificity, and accuracy of 89.2%, 66.7% and 80.6% with majority diagnosis of the expert physicians in discriminating cervical intraepithelial neoplasia (CIN +) relative to normal tissues. The proposed classifier also achieved an area under the curve of 84 when trained with majority diagnosis of the expert physicians. The results suggest that utilizing simple color-based features may enable unbiased automation of VILI cervigrams, opening the door to a full system of low-cost data acquisition complemented with automatic interpretation.

  15. Field experiments for studying the deposition of aerosols onto vegetation and other surfaces

    International Nuclear Information System (INIS)

    Jonas, R.; Heinemann, K.

    1986-01-01

    For some pollutions, dry deposition clearly predominates in the long-term mean over the wash-out or wet deposition. The deposition velocity or fall-out constant, defined as follows, is a measure of the dry deposition of pollutants onto the soil or vegetation: upsilonsub(g) = K/I, where upsilonsub (g) = deposition velocity (cms -1 ); K = contamination of the sampling surface per cm 2 area (quantity deposited per cm 2 ); I = time-integrated air concentration conventionally measured at a reference height of 1 m above the ground. The deposition velocity of radioactively labelled test aerosols (copper sulphate) onto grass, clover, various species of tree (common beech, hornbeam, red oak, common oak, horse chestnut, silver birch, Norway maple, common spruce, Scots pine, Japanese larch, European larch, common silver fir) as well as onto bare soil, water, metals and horizontal filter paper was determined in an extensive series of field tests at the Julich Nuclear Research Centre (Jonas, 1984; Jonas and Heinemann, 1985). For determination of the deposition velocities, the reader is referred to Jonas and Heinemann (1985). (author)

  16. A renormalizable extension of the NJL-model

    International Nuclear Information System (INIS)

    Langfeld, K.; Kettner, C.; Reinhardt, H.

    1996-01-01

    The Nambu-Jona-Lasinio model is supplemented by the quark interaction generated by the one-gluon exchange. The employed gluon propagator exhibits the correct large-momentum behavior of QCD, whereas the Landau pole at low energies is screened. The emerging constituent quark model is one-loop renormalizable and interpolates between the phenomenologically successful Nambu-Jona-Lasinio model (modified by a transversal projector) at low energies and perturbative QCD at high momenta. Consequently, the momentum dependence of the quark self-energy at high energy coincides with the prediction from perturbative QCD. The chiral phase transition is studied in dependence on the low-energy four-quark interaction strength in the Dyson-Schwinger equation approach. The critical exponents of the quark self-energy and the quark condensate are obtained. The latter exponent deviates from the NJL-result. Pion properties are addressed by means of the Bethe-Salpeter equation. The validity of the Gell-Mann-Oakes-Renner relation is verified. Finally, we study the conditions under which the Nambu-Jona-Lasinio model is a decent approximation to our renormalizable theory as well as the shortcoming of the NJL-model due to its inherent non-renormalizability. (orig.)

  17. Heliox allows for lower minute volume ventilation in an animal model of ventilator-induced lung injury.

    Directory of Open Access Journals (Sweden)

    Charlotte J Beurskens

    Full Text Available BACKGROUND: Helium is a noble gas with a low density, allowing for lower driving pressures and increased carbon dioxide (CO2 diffusion. Since application of protective ventilation can be limited by the development of hypoxemia or acidosis, we hypothesized that therefore heliox facilitates ventilation in an animal model of ventilator-induced lung injury. METHODS: Sprague-Dawley rats (N=8 per group were mechanically ventilated with heliox (50% oxygen; 50% helium. Controls received a standard gas mixture (50% oxygen; 50% air. VILI was induced by application of tidal volumes of 15 mL kg(-1; lung protective ventilated animals were ventilated with 6 mL kg(-1. Respiratory parameters were monitored with a pneumotach system. Respiratory rate was adjusted to maintain arterial pCO2 within 4.5-5.5 kPa, according to hourly drawn arterial blood gases. After 4 hours, bronchoalveolar lavage fluid (BALF was obtained. Data are mean (SD. RESULTS: VILI resulted in an increase in BALF protein compared to low tidal ventilation (629 (324 vs. 290 (181 μg mL(-1; p<0.05 and IL-6 levels (640 (8.7 vs. 206 (8.7 pg mL(-1; p<0.05, whereas cell counts did not differ between groups after this short course of mechanical ventilation. Ventilation with heliox resulted in a decrease in mean respiratory minute volume ventilation compared to control (123 ± 0.6 vs. 146 ± 8.9 mL min(-1, P<0.001, due to a decrease in respiratory rate (22 (0.4 vs. 25 (2.1 breaths per minute; p<0.05, while pCO2 levels and tidal volumes remained unchanged, according to protocol. There was no effect of heliox on inspiratory pressure, while compliance was reduced. In this mild lung injury model, heliox did not exert anti-inflammatory effects. CONCLUSIONS: Heliox allowed for a reduction in respiratory rate and respiratory minute volume during VILI, while maintaining normal acid-base balance. Use of heliox may be a useful approach when protective tidal volume ventilation is limited by the development of

  18. Inhibitor of neuronal nitric oxide synthase improves gas exchange in ventilator-induced lung injury after pneumonectomy

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    Suborov Evgeny V

    2012-06-01

    Full Text Available Abstract Background Mechanical ventilation with high tidal volumes may cause ventilator-induced lung injury (VILI and enhanced generation of nitric oxide (NO. We demonstrated in sheep that pneumonectomy followed by injurious ventilation promotes pulmonary edema. We wished both to test the hypothesis that neuronal NOS (nNOS, which is distributed in airway epithelial and neuronal tissues, could be involved in the pathogenesis of VILI and we also aimed at investigating the influence of an inhibitor of nNOS on the course of VILI after pneumonectomy. Methods Anesthetized sheep underwent right pneumonectomy, mechanical ventilation with tidal volumes (VT of 6 mL/kg and FiO2 0.5, and were subsequently randomized to a protectively ventilated group (PROTV; n = 8 keeping VT and FiO2 unchanged, respiratory rate (RR 25 inflations/min and PEEP 4 cm H2O for the following 8 hrs; an injuriously ventilated group with VT of 12 mL/kg, zero end-expiratory pressure, and FiO2 and RR unchanged (INJV; n = 8 and a group, which additionally received the inhibitor of nNOS, 7-nitroindazole (NI 1.0 mg/kg/h intravenously from 2 hours after the commencement of injurious ventilation (INJV + NI; n = 8. We assessed respiratory, hemodynamic and volumetric variables, including both the extravascular lung water index (EVLWI and the pulmonary vascular permeability index (PVPI. We measured plasma nitrite/nitrate (NOx levels and examined lung biopsies for lung injury score (LIS. Results Both the injuriously ventilated groups demonstrated a 2–3-fold rise in EVLWI and PVPI, with no significant effects of NI. In the INJV group, gas exchange deteriorated in parallel with emerging respiratory acidosis, but administration of NI antagonized the derangement of oxygenation and the respiratory acidosis significantly. NOx displayed no significant changes and NI exerted no significant effect on LIS in the INJV group. Conclusion Inhibition of nNOS improved gas exchange

  19. Inhibitor of neuronal nitric oxide synthase improves gas exchange in ventilator-induced lung injury after pneumonectomy.

    Science.gov (United States)

    Suborov, Evgeny V; Smetkin, Alexey A; Kondratiev, Timofey V; Valkov, Andrey Y; Kuzkov, Vsevolod V; Kirov, Mikhail Y; Bjertnaes, Lars J

    2012-06-21

    Mechanical ventilation with high tidal volumes may cause ventilator-induced lung injury (VILI) and enhanced generation of nitric oxide (NO). We demonstrated in sheep that pneumonectomy followed by injurious ventilation promotes pulmonary edema. We wished both to test the hypothesis that neuronal NOS (nNOS), which is distributed in airway epithelial and neuronal tissues, could be involved in the pathogenesis of VILI and we also aimed at investigating the influence of an inhibitor of nNOS on the course of VILI after pneumonectomy. Anesthetized sheep underwent right pneumonectomy, mechanical ventilation with tidal volumes (VT) of 6 mL/kg and FiO2 0.5, and were subsequently randomized to a protectively ventilated group (PROTV; n = 8) keeping VT and FiO2 unchanged, respiratory rate (RR) 25 inflations/min and PEEP 4 cm H2O for the following 8 hrs; an injuriously ventilated group with VT of 12 mL/kg, zero end-expiratory pressure, and FiO2 and RR unchanged (INJV; n = 8) and a group, which additionally received the inhibitor of nNOS, 7-nitroindazole (NI) 1.0 mg/kg/h intravenously from 2 hours after the commencement of injurious ventilation (INJV + NI; n = 8). We assessed respiratory, hemodynamic and volumetric variables, including both the extravascular lung water index (EVLWI) and the pulmonary vascular permeability index (PVPI). We measured plasma nitrite/nitrate (NOx) levels and examined lung biopsies for lung injury score (LIS). Both the injuriously ventilated groups demonstrated a 2-3-fold rise in EVLWI and PVPI, with no significant effects of NI. In the INJV group, gas exchange deteriorated in parallel with emerging respiratory acidosis, but administration of NI antagonized the derangement of oxygenation and the respiratory acidosis significantly. NOx displayed no significant changes and NI exerted no significant effect on LIS in the INJV group. Inhibition of nNOS improved gas exchange, but did not reduce lung water extravasation following

  20. Comparison of high and low virulence serotypes of Actinobacillus pleuropneumoniae by quantitative real-time PCR

    DEFF Research Database (Denmark)

    Schou, Kirstine Klitgaard; Angen, Øystein; Boye, Mette

    PCR data. Preliminary results showed that in both serotype 2 and serotype 6, the toxin producing gene apxIV was the most highly expressed of the investigated genes. The major difference observed between the two serotypes was that apfA, involved in type IV vili production, was significantly upregulated...... of high virulence while serotype 6 strains are normally found to be less pathogenic. To gain an understanding of the differential virulence of serotype 2 and 6, the expression of a panel of Ap genes during infection of porcine epithelial lung cells (SJPL) were examined by quantitative real-time PCR (q...... to be important for early establishment of the bacteria in the host were examined by qPCR. The genes examined were apfA, coding for a subunit of Type IV pili, kdsB coding for a gene involved in lippopolysacceride biosynthesis, and pgaB which is involved in biofilm formation, all three believed to be important...

  1. Impact of Different Tidal Volume Levels at Low Mechanical Power on Ventilator-Induced Lung Injury in Rats

    Directory of Open Access Journals (Sweden)

    Lillian Moraes

    2018-04-01

    Full Text Available Tidal volume (VT has been considered the main determinant of ventilator-induced lung injury (VILI. Recently, experimental studies have suggested that mechanical power transferred from the ventilator to the lungs is the promoter of VILI. We hypothesized that, as long as mechanical power is kept below a safe threshold, high VT should not be injurious. The present study aimed to investigate the impact of different VT levels and respiratory rates (RR on lung function, diffuse alveolar damage (DAD, alveolar ultrastructure, and expression of genes related to inflammation [interleukin (IL-6], alveolar stretch (amphiregulin, epithelial [club cell secretory protein (CC16] and endothelial [intercellular adhesion molecule (ICAM-1] cell injury, and extracellular matrix damage [syndecan-1, decorin, and metalloproteinase (MMP-9] in experimental acute respiratory distress syndrome (ARDS under low-power mechanical ventilation. Twenty-eight Wistar rats received Escherichia coli lipopolysaccharide intratracheally. After 24 h, 21 animals were randomly assigned to ventilation (2 h with low mechanical power at three different VT levels (n = 7/group: (1 VT = 6 mL/kg and RR adjusted to normocapnia; (2 VT = 13 mL/kg; and 3 VT = 22 mL/kg. In the second and third groups, RR was adjusted to yield low mechanical power comparable to that of the first group. Mechanical power was calculated as [(ΔP,L2/Est,L/2]× RR (ΔP,L = transpulmonary driving pressure, Est,L = static lung elastance. Seven rats were not mechanically ventilated (NV and were used for molecular biology analysis. Mechanical power was comparable among groups, while VT gradually increased. ΔP,L and mechanical energy were higher in VT = 22 mL/kg than VT = 6 mL/kg and VT = 13 mL/kg (p < 0.001 for both. Accordingly, DAD score increased in VT = 22 mL/kg compared to VT = 6 mL/kg and VT = 13 mL/kg [23(18.5–24.75 vs. 16(12–17.75 and 16(13.25–18, p < 0.05, respectively]. VT = 22 mL/kg was associated with higher

  2. Incremento de la detección de lesiones cervicales mediante inspección visual. Puerto Esperanza. 2008 Detection Increase of cervix lesions by means of visual examination in Puerto Esperanza, 2008

    Directory of Open Access Journals (Sweden)

    José G Sanabria Negrín

    2011-09-01

    Full Text Available Las pruebas visuales del cuello uterino mediante ácido acético al 4-5 % (IVA y Lugol (IVSL contribuyen a detectar lesiones. Este constituye el primer reporte de su uso en Cuba. Objetivo: demostrar el incremento de la detección de lesiones cervicales premalignas y malignas mediante el uso de pruebas visuales en la APS. Método: estudio de casos-controles en Puerto Esperanza, Viñales, 2008. Universo: Mujeres de 15-64 años con relaciones sexuales penetrantes. Muestra: Mujeres con pruebas visuales y citología alterada (n1= 18 casos o no (n2= 178 controles. En Patología de Cuello se les practicó colposcopia y biopsia dirigida o por conización con asa diatérmica. Se calcularon frecuencias absolutas y relativas porcentuales y la probabilidad de detectar lesiones por las pruebas aisladas o en conjunto, además de las pruebas de rendimiento diagnóstico. Resultados: IVA e IVSL resultaron positivas en 92.9% y 79.6%, respectivamente. La probabilidad conjunta de tener lesiones fue 0.7395. Con citología alterada el 88.9 % tenía IVA+ y 77,9 % tuvo IVSL+. La colposcopia resultó positiva en el 70.9 % y la probabilidad de tener una lesión mediante pruebas visuales y la colposcopia fue 0.516. De las 136 mujeres biopsiadas resultaron útiles el 99.3%, de las cuales casi el 50 % tuvo lesiones premalignas/malignas. Las pruebas de rendimiento fueron superiores para la IVA y la IVSL que para la citología. No se detectó cáncer invasor, pero sí carcinomas in situ. Conclusión: las pruebas visuales aumentaron la cantidad de diagnósticos en 4 veces y debe generalizarse su uso.Visual examination of cervix using acetic acid up to 4-5% (VIA and Lugol's solution (VILI contribute to detect lesions. This constitutes the first report of their use in Cuba. Objective: to demonstrate the detection increase of pre-malignant and malignant cervical lesions by means of visual examination in Primary Health Care. Method: control-case studies in Puerto Esperanza, Vi

  3. Produtividade de cultivares de alho na região paulista de Tietê Garlic cultivars yield in Tietê region, São Paulo State, Brazil

    Directory of Open Access Journals (Sweden)

    Paulo Espíndola Trani

    2008-01-01

    Full Text Available O custo elevado das sementes (bulbilhos de alho nobre e a vernalização podem aumentar a produtividade da cultura, mas dificultam seu cultivo por pequenos produtores, responsáveis pela maior parte da produção no Brasil. Assim, estudos de seleção de sementes de menor custo como os alhos comuns, feitos regionalmente, e de comparação com alho vernalizado quanto à produtividade, são fundamentais. O objetivo deste trabalho foi a avaliação da produtividade de quatro cultivares de alho comum não vernalizado (Assaí, Gigante de Curitibanos, Santa Catarina Branco e Santa Catarina Roxo, em comparação com alho chinês vernalizado Jonas (armazenamento dos bulbos a 4 ºC por 40 dias. O delineamento experimental foi em blocos casualizados com cinco repetições. O experimento foi realizado em área experimental da APTA-UPD de Tietê (SP, de março a setembro de 2005. A variedade mais produtiva foi Jonas, sem diferir de Santa Catarina Roxo, Santa Catarina Branco e Assaí 3702, com 8,4; 7,6; 7,4 e 6,9 t ha-1 respectivamente e também com as maiores massas médias de bulbos (30,5; 27,0; 26,3 e 24,6g respectivamente. Quanto ao diâmetro do bulbo, os alhos comuns, exceto Gigante de Curitibanos, produziram bulbos tamanho 4 (36-45 mm. Para produtividade e massa do bulbo, a cultivar Gigante de Curitibanos foi inferior a Jonas.The high cost of garlic seed and the refrigeration process may increase yield, but it is a barrier for small farmers who are responsible for the large Brazilian production. Therefore, research seeking low cost garlic seed, regionally made, and competition studies for yield between refrigerated and no refrigerated cultivars are fundamental. This work aimed to evaluate yield and bulb quality of four no refrigerated garlic varieties (Assaí 3702, Gigante de Curitibanos, Santa Catarina Branco and Santa Catarina Roxo and the refrigerated type Jonas (storage at 4º C for 40 days. The field trial was carried out during March

  4. Conservative fluid management prevents age-associated ventilator induced mortality.

    Science.gov (United States)

    Herbert, Joseph A; Valentine, Michael S; Saravanan, Nivi; Schneck, Matthew B; Pidaparti, Ramana; Fowler, Alpha A; Reynolds, Angela M; Heise, Rebecca L

    2016-08-01

    Approximately 800 thousand patients require mechanical ventilation in the United States annually with an in-hospital mortality rate of over 30%. The majority of patients requiring mechanical ventilation are over the age of 65 and advanced age is known to increase the severity of ventilator-induced lung injury (VILI) and in-hospital mortality rates. However, the mechanisms which predispose aging ventilator patients to increased mortality rates are not fully understood. Ventilation with conservative fluid management decreases mortality rates in acute respiratory distress patients, but to date there has been no investigation of the effect of conservative fluid management on VILI and ventilator associated mortality rates. We hypothesized that age-associated increases in susceptibility and incidence of pulmonary edema strongly promote age-related increases in ventilator associated mortality. 2month old and 20month old male C57BL6 mice were mechanically ventilated with either high tidal volume (HVT) or low tidal volume (LVT) for up to 4h with either liberal or conservative fluid support. During ventilation, lung compliance, total lung capacity, and hysteresis curves were quantified. Following ventilation, bronchoalveolar lavage fluid was analyzed for total protein content and inflammatory cell infiltration. Wet to dry ratios were used to directly measure edema in excised lungs. Lung histology was performed to quantify alveolar barrier damage/destruction. Age matched non-ventilated mice were used as controls. At 4h, both advanced age and HVT ventilation significantly increased markers of inflammation and injury, degraded pulmonary mechanics, and decreased survival rates. Conservative fluid support significantly diminished pulmonary edema and improved pulmonary mechanics by 1h in advanced age HVT subjects. In 4h ventilations, conservative fluid support significantly diminished pulmonary edema, improved lung mechanics, and resulted in significantly lower mortality rates in

  5. μ-PIV/Shadowgraphy measurements to elucidate dynamic physicochemical interactions in a multiphase model of pulmonary airway reopening

    Science.gov (United States)

    Yamaguchi, Eiichiro

    2010-10-01

    We employ micro-particle image velocimetry (μ-PIV) and shadowgraphy to measure the ensemble-averaged fluid-phase velocity field and interfacial geometry during pulsatile bubble propagation that includes a reverse-flow phase under influence of exogenous lung surfactant (Infasurf). Disease states such as respiratory distress syndrome (RDS) are characterized by insufficient pulmonary surfactant concentrations that enhance airway occlusion and collapse. Subsequent airway reopening, driven by mechanical ventilation, may generate damaging stresses that cause ventilator-induced lung injury (VILI). It is hypothesized that reverse flow may enhance surfactant uptake and protect the lung from VILI. The microscale observations conducted in this study will provide us with a significant understanding of dynamic physicochemical interactions that can be manipulated to reduce the magnitude of this damaging mechanical stimulus during airway reopening. Bubble propagation through a liquid-occluded fused glass capillary tube is controlled by linear-motor-driven syringe pumps that provide mean and sinusoidal velocity components. A translating microscope stage mechanically subtracts the mean velocity of the bubble tip in order to hold the progressing bubble tip in the microscope field of view. To optimize the signal-to-noise ratio near the bubble tip, μ-PIV and shadow images are recorded in separate trials then combined during post-processing with help of a custom-designed micro scale marker. Non-specific binding of Infasurf proteins to the channel wall is controlled by oxidation and chemical treatment of the glass surface. The colloidal stability and dynamic/static surface properties of the Infasurf-PIV particle solution are carefully adjusted based on Langmuir trough measurements. The Finite Time Lyapunov Exponent (FTLE) is computed to provide a Lagrangian perspective for comparison with our boundary element predictions.

  6. Nicotinamide exacerbates hypoxemia in ventilator-induced lung injury independent of neutrophil infiltration.

    Directory of Open Access Journals (Sweden)

    Heather D Jones

    Full Text Available Ventilator-induced lung injury is a form of acute lung injury that develops in critically ill patients on mechanical ventilation and has a high degree of mortality. Nicotinamide phosphoribosyltransferase is an enzyme that is highly upregulated in ventilator-induced lung injury and exacerbates the injury when given exogenously. Nicotinamide (vitamin B3 directly inhibits downstream pathways activated by Nicotinamide phosphoribosyltransferase and is protective in other models of acute lung injury.We administered nicotinamide i.p. to mice undergoing mechanical ventilation with high tidal volumes to study the effects of nicotinamide on ventilator-induced lung injury. Measures of injury included oxygen saturations and bronchoalveolar lavage neutrophil counts, protein, and cytokine levels. We also measured expression of nicotinamide phosophoribosyltransferase, and its downstream effectors Sirt1 and Cebpa, Cebpb, Cebpe. We assessed the effect of nicotinamide on the production of nitric oxide during ventilator-induced lung injury. We also studied the effects of ventilator-induced lung injury in mice deficient in C/EBPε.Nicotinamide treatment significantly inhibited neutrophil infiltration into the lungs during ventilator-induced lung injury, but did not affect protein leakage or cytokine production. Surprisingly, mice treated with nicotinamide developed significantly worse hypoxemia during mechanical ventilation. This effect was not linked to increases in nitric oxide production or alterations in expression of Nicotinamide phosphoribosyl transferase, Sirt1, or Cebpa and Cebpb. Cebpe mRNA levels were decreased with either nicotinamide treatment or mechanical ventilation, but mice lacking C/EBPε developed the same degree of hypoxemia and ventilator-induced lung injury as wild-type mice.Nicotinamide treatment during VILI inhibits neutrophil infiltration of the lungs consistent with a strong anti-inflammatory effect, but paradoxically also leads to the

  7. Model-based setting of inspiratory pressure and respiratory rate in pressure-controlled ventilation

    International Nuclear Information System (INIS)

    Schranz, C; Möller, K; Becher, T; Schädler, D; Weiler, N

    2014-01-01

    Mechanical ventilation carries the risk of ventilator-induced-lung-injury (VILI). To minimize the risk of VILI, ventilator settings should be adapted to the individual patient properties. Mathematical models of respiratory mechanics are able to capture the individual physiological condition and can be used to derive personalized ventilator settings. This paper presents model-based calculations of inspiration pressure (p I ), inspiration and expiration time (t I , t E ) in pressure-controlled ventilation (PCV) and a retrospective evaluation of its results in a group of mechanically ventilated patients. Incorporating the identified first order model of respiratory mechanics in the basic equation of alveolar ventilation yielded a nonlinear relation between ventilation parameters during PCV. Given this patient-specific relation, optimized settings in terms of minimal p I and adequate t E can be obtained. We then retrospectively analyzed data from 16 ICU patients with mixed pathologies, whose ventilation had been previously optimized by ICU physicians with the goal of minimization of inspiration pressure, and compared the algorithm's ‘optimized’ settings to the settings that had been chosen by the physicians. The presented algorithm visualizes the patient-specific relations between inspiration pressure and inspiration time. The algorithm's calculated results highly correlate to the physician's ventilation settings with r = 0.975 for the inspiration pressure, and r = 0.902 for the inspiration time. The nonlinear patient-specific relations of ventilation parameters become transparent and support the determination of individualized ventilator settings according to therapeutic goals. Thus, the algorithm is feasible for a variety of ventilated ICU patients and has the potential of improving lung-protective ventilation by minimizing inspiratory pressures and by helping to avoid the build-up of clinically significant intrinsic positive end

  8. Lower tidal volume strategy (≈3 ml/kg) combined with extracorporeal CO2 removal versus 'conventional' protective ventilation (6 ml/kg) in severe ARDS: the prospective randomized Xtravent-study.

    Science.gov (United States)

    Bein, Thomas; Weber-Carstens, Steffen; Goldmann, Anton; Müller, Thomas; Staudinger, Thomas; Brederlau, Jörg; Muellenbach, Ralf; Dembinski, Rolf; Graf, Bernhard M; Wewalka, Marlene; Philipp, Alois; Wernecke, Klaus-Dieter; Lubnow, Matthias; Slutsky, Arthur S

    2013-05-01

    Acute respiratory distress syndrome is characterized by damage to the lung caused by various insults, including ventilation itself, and tidal hyperinflation can lead to ventilator induced lung injury (VILI). We investigated the effects of a low tidal volume (V(T)) strategy (V(T) ≈ 3 ml/kg/predicted body weight [PBW]) using pumpless extracorporeal lung assist in established ARDS. Seventy-nine patients were enrolled after a 'stabilization period' (24 h with optimized therapy and high PEEP). They were randomly assigned to receive a low V(T) ventilation (≈3 ml/kg) combined with extracorporeal CO2 elimination, or to a ARDSNet strategy (≈6 ml/kg) without the extracorporeal device. The primary outcome was the 28-days and 60-days ventilator-free days (VFD). Secondary outcome parameters were respiratory mechanics, gas exchange, analgesic/sedation use, complications and hospital mortality. Ventilation with very low V(T)'s was easy to implement with extracorporeal CO2-removal. VFD's within 60 days were not different between the study group (33.2 ± 20) and the control group (29.2 ± 21, p = 0.469), but in more hypoxemic patients (PaO2/FIO2 ≤150) a post hoc analysis demonstrated significant improved VFD-60 in study patients (40.9 ± 12.8) compared to control (28.2 ± 16.4, p = 0.033). The mortality rate was low (16.5%) and did not differ between groups. The use of very low V(T) combined with extracorporeal CO2 removal has the potential to further reduce VILI compared with a 'normal' lung protective management. Whether this strategy will improve survival in ARDS patients remains to be determined (Clinical trials NCT 00538928).

  9. Model-based setting of inspiratory pressure and respiratory rate in pressure-controlled ventilation.

    Science.gov (United States)

    Schranz, C; Becher, T; Schädler, D; Weiler, N; Möller, K

    2014-03-01

    Mechanical ventilation carries the risk of ventilator-induced-lung-injury (VILI). To minimize the risk of VILI, ventilator settings should be adapted to the individual patient properties. Mathematical models of respiratory mechanics are able to capture the individual physiological condition and can be used to derive personalized ventilator settings. This paper presents model-based calculations of inspiration pressure (pI), inspiration and expiration time (tI, tE) in pressure-controlled ventilation (PCV) and a retrospective evaluation of its results in a group of mechanically ventilated patients. Incorporating the identified first order model of respiratory mechanics in the basic equation of alveolar ventilation yielded a nonlinear relation between ventilation parameters during PCV. Given this patient-specific relation, optimized settings in terms of minimal pI and adequate tE can be obtained. We then retrospectively analyzed data from 16 ICU patients with mixed pathologies, whose ventilation had been previously optimized by ICU physicians with the goal of minimization of inspiration pressure, and compared the algorithm's 'optimized' settings to the settings that had been chosen by the physicians. The presented algorithm visualizes the patient-specific relations between inspiration pressure and inspiration time. The algorithm's calculated results highly correlate to the physician's ventilation settings with r = 0.975 for the inspiration pressure, and r = 0.902 for the inspiration time. The nonlinear patient-specific relations of ventilation parameters become transparent and support the determination of individualized ventilator settings according to therapeutic goals. Thus, the algorithm is feasible for a variety of ventilated ICU patients and has the potential of improving lung-protective ventilation by minimizing inspiratory pressures and by helping to avoid the build-up of clinically significant intrinsic positive end-expiratory pressure.

  10. Low tidal volume ventilation ameliorates left ventricular dysfunction in mechanically ventilated rats following LPS-induced lung injury.

    Science.gov (United States)

    Cherpanath, Thomas G V; Smeding, Lonneke; Hirsch, Alexander; Lagrand, Wim K; Schultz, Marcus J; Groeneveld, A B Johan

    2015-10-07

    High tidal volume ventilation has shown to cause ventilator-induced lung injury (VILI), possibly contributing to concomitant extrapulmonary organ dysfunction. The present study examined whether left ventricular (LV) function is dependent on tidal volume size and whether this effect is augmented during lipopolysaccharide(LPS)-induced lung injury. Twenty male Wistar rats were sedated, paralyzed and then randomized in four groups receiving mechanical ventilation with tidal volumes of 6 ml/kg or 19 ml/kg with or without intrapulmonary administration of LPS. A conductance catheter was placed in the left ventricle to generate pressure-volume loops, which were also obtained within a few seconds of vena cava occlusion to obtain relatively load-independent LV systolic and diastolic function parameters. The end-systolic elastance / effective arterial elastance (Ees/Ea) ratio was used as the primary parameter of LV systolic function with the end-diastolic elastance (Eed) as primary LV diastolic function. Ees/Ea decreased over time in rats receiving LPS (p = 0.045) and high tidal volume ventilation (p = 0.007), with a lower Ees/Ea in the rats with high tidal volume ventilation plus LPS compared to the other groups (p tidal volume ventilation without LPS (p = 0.223). A significant interaction (p tidal ventilation and LPS for Ees/Ea and Eed, and all rats receiving high tidal volume ventilation plus LPS died before the end of the experiment. Low tidal volume ventilation ameliorated LV systolic and diastolic dysfunction while preventing death following LPS-induced lung injury in mechanically ventilated rats. Our data advocates the use of low tidal volumes, not only to avoid VILI, but to avert ventilator-induced myocardial dysfunction as well.

  11. Cervical cancer screening and treatment of cervical intraepithelial neoplasia in female sex workers using “screen and treat” approach

    Directory of Open Access Journals (Sweden)

    Joshi S

    2015-05-01

    Full Text Available Smita Joshi,1 Vinay Kulkarni,2 Trupti Darak,2 Uma Mahajan,1 Yogesh Srivastava,3 Sanjay Gupta,3 Sumitra Krishnan,1 Mahesh Mandolkar,2 Alok Chandra Bharti31Hirabai Cowasji Jehangir Medical Research Institute (HCJMRI, Jehangir Hospital Premises, Pune, Maharashtra, India; 2Prayas Health Group, Amrita Clinic, Pune, India; 3Institute for Cytology and Preventive Oncology, Indian Council of Medical Research, New Delhi, IndiaObjective: Female sex workers (FSWs are at an increased risk of human immunodeficiency virus (HIV as well as human papillomavirus (HPV infections and thus have an increased risk of cervical intraepithelial neoplasia (CIN and cervical cancer. We evaluated the feasibility of “screen and treat approach” for cervical cancer prevention and the performance of different screening tests among FSWs.Methods: Women were screened using cytology, VIA (visual inspection with acetic acid, and VILI (visual inspection with Lugol’s iodine and underwent colposcopy, biopsy, and immediate treatment using cold coagulation, if indicated, at the same visit.Results: We screened 300 FSWs of whom 200 (66.67% were HIV uninfected and 100 (33.34% were HIV infected. The overall prevalence of CIN 2–3 lesions was 4.7%. But all women with CIN 2–3 lesions were HIV infected, and thus the prevalence of CIN 2–3 lesions in HIV-infected FSWs was 14/100 (14%, 95% confidence interval: 7.2–20.8. All of them screened positive by all three screening tests. Cold coagulation was well tolerated, with no appreciable side effects.Conclusion: Cervical cancer prevention by “screen and treat” approach using VIA, followed by ablative treatment, in this high-risk group of women is feasible and can be implemented through various targeted intervention programs. Keywords: cytology, VIA, VILI, CIN, cold coagulation, cervical cancer, HPV, FSWs

  12. Recurrence of cervical intraepithelial lesions after thermo-coagulation in HIV-positive and HIV-negative Nigerian women.

    Science.gov (United States)

    Oga, Emmanuel A; Brown, Jessica P; Brown, Clayton; Dareng, Eileen; Adekanmbi, Victor; Odutola, Michael; Olaniyan, Olayinka; Offiong, Richard; Obende, Kayode; Adewole, Ayodele Stephen; Peter, Achara; Dakum, Patrick; Adebamowo, Clement

    2016-05-11

    The burden of cervical cancer remains huge globally, more so in sub-Saharan Africa. Effectiveness of screening, rates of recurrence following treatment and factors driving these in Africans have not been sufficiently studied. The purpose of this study therefore was to investigate factors associated with recurrence of cervical intraepithelial lesions following thermo-coagulation in HIV-positive and HIV-negative Nigerian women using Visual Inspection with Acetic Acid (VIA) or Lugol's Iodine (VILI) for diagnosis. A retrospective cohort study was conducted, recruiting participants from the cervical cancer "see and treat" program of IHVN. Data from 6 sites collected over a 4-year period was used. Inclusion criteria were: age ≥18 years, baseline HIV status known, VIA or VILI positive and thermo-coagulation done. Logistic regression was performed to examine the proportion of women with recurrence and to examine factors associated with recurrence. Out of 177 women included in study, 67.8 % (120/177) were HIV-positive and 32.2 % (57/177) were HIV-negative. Recurrence occurred in 16.4 % (29/177) of participants; this was 18.3 % (22/120) in HIV-positive women compared to 12.3 % (7/57) in HIV-negative women but this difference was not statistically significant (p-value 0.31). Women aged ≥30 years were much less likely to develop recurrence, adjusted OR = 0.34 (95 % CI = 0.13, 0.92). Among HIV-positive women, CD4 count thermo-coagulation occurs in a significant proportion of women. HIV-positive women with low CD4 counts are at increased risk of recurrent lesions and may be related to immunosuppression.

  13. The role of high airway pressure and dynamic strain on ventilator-induced lung injury in a heterogeneous acute lung injury model.

    Science.gov (United States)

    Jain, Sumeet V; Kollisch-Singule, Michaela; Satalin, Joshua; Searles, Quinn; Dombert, Luke; Abdel-Razek, Osama; Yepuri, Natesh; Leonard, Antony; Gruessner, Angelika; Andrews, Penny; Fazal, Fabeha; Meng, Qinghe; Wang, Guirong; Gatto, Louis A; Habashi, Nader M; Nieman, Gary F

    2017-12-01

    Acute respiratory distress syndrome causes a heterogeneous lung injury with normal and acutely injured lung tissue in the same lung. Improperly adjusted mechanical ventilation can exacerbate ARDS causing a secondary ventilator-induced lung injury (VILI). We hypothesized that a peak airway pressure of 40 cmH 2 O (static strain) alone would not cause additional injury in either the normal or acutely injured lung tissue unless combined with high tidal volume (dynamic strain). Pigs were anesthetized, and heterogeneous acute lung injury (ALI) was created by Tween instillation via a bronchoscope to both diaphragmatic lung lobes. Tissue in all other lobes was normal. Airway pressure release ventilation was used to precisely regulate time and pressure at both inspiration and expiration. Animals were separated into two groups: (1) over-distension + high dynamic strain (OD + H DS , n = 6) and (2) over-distension + low dynamic strain (OD + L DS , n = 6). OD was caused by setting the inspiratory pressure at 40 cmH 2 O and dynamic strain was modified by changing the expiratory duration, which varied the tidal volume. Animals were ventilated for 6 h recording hemodynamics, lung function, and inflammatory mediators followed by an extensive necropsy. In normal tissue (N T ), OD + L DS caused minimal histologic damage and a significant reduction in BALF total protein (p < 0.05) and MMP-9 activity (p < 0.05), as compared with OD + H DS . In acutely injured tissue (ALI T ), OD + L DS resulted in reduced histologic injury and pulmonary edema (p < 0.05), as compared with OD + H DS . Both N T and ALI T are resistant to VILI caused by OD alone, but when combined with a H DS , significant tissue injury develops.

  14. Microarray Meta-Analysis Identifies Acute Lung Injury Biomarkers in Donor Lungs That Predict Development of Primary Graft Failure in Recipients

    Science.gov (United States)

    Haitsma, Jack J.; Furmli, Suleiman; Masoom, Hussain; Liu, Mingyao; Imai, Yumiko; Slutsky, Arthur S.; Beyene, Joseph; Greenwood, Celia M. T.; dos Santos, Claudia

    2012-01-01

    Objectives To perform a meta-analysis of gene expression microarray data from animal studies of lung injury, and to identify an injury-specific gene expression signature capable of predicting the development of lung injury in humans. Methods We performed a microarray meta-analysis using 77 microarray chips across six platforms, two species and different animal lung injury models exposed to lung injury with or/and without mechanical ventilation. Individual gene chips were classified and grouped based on the strategy used to induce lung injury. Effect size (change in gene expression) was calculated between non-injurious and injurious conditions comparing two main strategies to pool chips: (1) one-hit and (2) two-hit lung injury models. A random effects model was used to integrate individual effect sizes calculated from each experiment. Classification models were built using the gene expression signatures generated by the meta-analysis to predict the development of lung injury in human lung transplant recipients. Results Two injury-specific lists of differentially expressed genes generated from our meta-analysis of lung injury models were validated using external data sets and prospective data from animal models of ventilator-induced lung injury (VILI). Pathway analysis of gene sets revealed that both new and previously implicated VILI-related pathways are enriched with differentially regulated genes. Classification model based on gene expression signatures identified in animal models of lung injury predicted development of primary graft failure (PGF) in lung transplant recipients with larger than 80% accuracy based upon injury profiles from transplant donors. We also found that better classifier performance can be achieved by using meta-analysis to identify differentially-expressed genes than using single study-based differential analysis. Conclusion Taken together, our data suggests that microarray analysis of gene expression data allows for the detection of

  15. Evaluation of the Applicability of HTML5 for Mobile Applications in Resource-Constrained Edge Environments

    Science.gov (United States)

    2014-07-01

    fully supported by the HTML5 standard via the HTML5 File API drafted by W3C [ Ranganathan 2013]. Figure 6 shows a JavaScript code example that...W3C). May 2012. http://dev.w3.org/geo/api/spec-source.html [Pusher 2012] Pusher Ltd. Pusher. http://pusher.com (2012). [ Ranganathan 2013... Ranganathan , Arun & Sicking, Jonas. “File API.” World Wide Web Consortium (W3C). 2013. http://www.w3.org/TR/FileAPI/ [Regmi 2011] Regni,Saroj Sharan

  16. Las tecnologías de manipulación de genes humanos como imperativo tecnológico: análisis desde la óptica del principalismo bioético y el principio de la responsabilidad

    Directory of Open Access Journals (Sweden)

    Ana Rosa Casanova Perdomo

    2011-01-01

    razones a favor y en contra de hacer o no hacer una investigación y por ello nuevas bases de sustentaciones teórico-metodológicas más abarcadoras que las del principalismo. Se demuestra la validez del Principio de la Responsabilidad de Hans Jonas que, como evaluación crítica de la ciencia y la tecnología modernas, llama a actuar con cautela y humildad frente al enorme poder transformador de la tecnociencia pues el orden ético está presente, no como realidad visible, sino como un llamado que pide calma, prudencia y equilibrio.

  17. Hirschegg '95: Dynamical properties of hadrons in nuclear matter. Proceedings

    International Nuclear Information System (INIS)

    Feldmeier, H.; Noerenberg, W.

    1995-01-01

    The following topics were dealt with: Chiral symmetry, chiral condensates, in-medium effective chiral Lagrangians, Δ's in nuclei, nonperturbative QCD, electron scattering from nuclear matter, nuclear shadowing, QCD sum rules, deconfinement, ultrarelativistic heavy ion collisions, nuclear dimuon and electron pair production, photoproduction from nuclei, subthreshold K + production, kaon polarization in nuclear matter, charged pion production in relativistic heavy ion collisions, the Nambu-Jona-Lasinio model, the SU(3) L xSU(3) R sigma model, nonequilibrium dense nuclear matter, pion pair production at finite temperature. (HSI)

  18. The spontaneous breakdown of chiral symmetry in QCD

    International Nuclear Information System (INIS)

    Yoshida, K.

    1980-02-01

    It is suggested that the usual path integral representation of Euclidean vacuum amplitude (tunneling amplitude) in QCD must be supplemented by the explicit boundary condition corresponding to the spontaneous breaking of chiral SU(N) x SU(N). Adopting the trial wave function introduced by Nambu and Jona-Lasinio, one sees that such a path integral automatically breaks also the additional chiral U(1) symmetry of massless quarks. The catastrophe of semi-classical approach to QCD and 'U(1) problem' would be avoided in this way and one has, in principle, a better starting point for the self-consistent calculation

  19. Animafestivali võit Saksamaale

    Index Scriptorium Estoniae

    2006-01-01

    23. nov. PÖFFi raames toimuval animafilmifestifalil "Animated Dreams" peavõidu sai sakslane Andreas Hykade filmiga "Äbarik" ("Der Kloane"), eriauhinna said portgallanna Regina Pessoa "Traagiline õnneliku lõpuga lugu" ja tšehh Milos Tomici film "Savist tuvi". Parim lugu oli rootslase Jonas Odelli "Eales pole enam nii, kui esimesel korral!", parim disain oli inglase Run Wrake'i filmil "Jänes". Balti- ja Põhjamaade Anoba auhinna sai Ami Lindblomi "Vastupandamatu naeratus" ("Ilo irti"). Järgmisele Anobale nomineeriti Mati Küti "Une instituut"

  20. Studying medium effects with the optimized δ expansion

    International Nuclear Information System (INIS)

    Krein, G.; Menezes, D.P.; Nielsen, M.; Pinto, M.B.

    1995-04-01

    The possibility of using the optimized δ expansion for studying medium effects on hadronic properties in quark or nuclear matter is investigated. The δ expansion is employed to study density effects with two commonly used models in hadron and nuclear physics, the Nambu-Jona-Lasinio model for the dynamical chiral symmetry breaking and the Walecka model for the equation of state of nuclear matter. The results obtained with the δ expansion are compared to those obtained with the traditional Hartree-Fock approximation. Perspectives for using the δ expansion in other field theoretic models in hadron and nuclear physics are discussed. (author). 17 refs, 9 figs

  1. Studying medium effects with the optimized {delta} expansion

    Energy Technology Data Exchange (ETDEWEB)

    Krein, G [Instituto de Fisica Teorica (IFT), Sao Paulo, SP (Brazil); Menezes, D P [Santa Catarina Univ., Florianopolis, SC (Brazil). Dept. de Fisica; Nielsen, M [Sao Paulo Univ., SP (Brazil). Inst. de Fisica; Pinto, M B [Montpellier-2 Univ., 34 (France). Lab. de Physique Mathematique

    1995-04-01

    The possibility of using the optimized {delta} expansion for studying medium effects on hadronic properties in quark or nuclear matter is investigated. The {delta} expansion is employed to study density effects with two commonly used models in hadron and nuclear physics, the Nambu-Jona-Lasinio model for the dynamical chiral symmetry breaking and the Walecka model for the equation of state of nuclear matter. The results obtained with the {delta} expansion are compared to those obtained with the traditional Hartree-Fock approximation. Perspectives for using the {delta} expansion in other field theoretic models in hadron and nuclear physics are discussed. (author). 17 refs, 9 figs.

  2. Principios bioéticos en salud pública: limitaciones y propuestas Bioethical principles in public health: limitations and proposals

    Directory of Open Access Journals (Sweden)

    Fermin Roland Schramm

    2001-08-01

    Full Text Available Este artículo intenta caracterizar la especificidad de los problemas morales en salud pública y analizar la aplicabilidad del modelo principialista como padrón para dirimir sus conflictos. Aunque considerado pertinente para la bioética clínica, este modelo no es aplicable sin más a los dilemas en salud pública, puesto que se fundamenta en la moral de las interrelaciones médico-paciente. Se analiza la pertinencia de los principios de "solidaridad", de "responsabilidad óntica" según Jonas, y de "responsabilidad diacónica" según Lévinas, destacando la inaplicabilidad del primero y la posible adaptación de los otros dos a la salud pública. A ese respecto se discute la posibilidad de vincular la preocupación ontológica de Jonas y la trascendental de Lévinas, proponiendo un principio de protección que sería más adecuado a los propósitos de una ética de la salud pública, permitiendo identificar claramente los objetivos y los actores implicados en una implementación de políticas públicas moralmente correctas y pragmáticamente efectivas.We propose to analyze the specificity of ethical problems in public health issues and to elucidate the applicability of principlism as a problem-solving strategy in this realm. Although well-established in clinical ethics, principlism is not an adequate model to be used in public health, since it is basically intended to serve as a moral guide in the physician-patient encounter. We discuss the possible adequacy of principles like "solidarity", "ontic responsibility" (as proposed by Jonas, and "caring or diaconal responsibility" as presented by Lévinas. Solidarity appears to be insufficiently specified, whereas the other two perspectives may be adapted to public health issues by bringing together Jonas´ ontological and Lévinas´ transcendental concerns to form a principle of protection that might better serve the purposes of such an ethics. This principle would help to identify more clearly

  3. Description of hot compressed hadronic matter based on an effective chiral Lagrangian

    Energy Technology Data Exchange (ETDEWEB)

    Florkowski, W. [Institute of Nuclear Physics, Cracow (Poland)

    1996-11-01

    In this report we give the review of the recent results obtained in the Nambu-Jona-Lasinio (NJL) model, describing the properties of hot compressed matter. The first large class problems concerns the behaviour of static meson correlation functions. In particular, this includes the investigation of the screening of meson fields at finite temperature or density. Another wide range of problems presented in our report concerns the formulation of the transport theory for the NJL model and its applications to the description of high energy nuclear collision. 86 refs, 35 figs.

  4. International recognition for ageing research: John Scott Award-2014 to Leonard Hayflick and Paul Moorhead

    OpenAIRE

    Rattan, Suresh

    2014-01-01

    It is with great pleasure and pride that we share the news of the award of the 2014 “City of Philadelphia John Scott Award”, to Dr. Leonard Hayflick and Dr. Paul Moorhead, for their research on ageing. The press release announcing the award states that: “from the first awarded in 1822, the Award is the oldest scientific award in the United States and, as a legacy to Benjamin Franklin, they are in the historic company of past winners who include Marie Curie, Thomas Edison, Jonas Salk, Irving L...

  5. Agouron and immune response to commercialize remune immune-based treatment.

    Science.gov (United States)

    James, J S

    1998-06-19

    Agouron Pharmaceuticals agreed in June to collaborate with The Immune Response Corporation on the final development and marketing of an immune-based treatment for HIV. Remune, the vaccine developed by Dr. Jonas Salk, is currently in Phase III randomized trials with 2,500 patients, and the trials are expected to be completed in April 1999. Immune-based treatments have been difficult to test, as there is no surrogate marker, like viral load, to determine if the drug is working. Agouron agreed to participate in the joint venture after reviewing encouraging results from preliminary trials in which remune was taken in combination with highly active antiretroviral drugs.

  6. Constantin Levaditi (1874-1953): a pioneer in Immunology and Virology.

    Science.gov (United States)

    Kalantzis, George; Skiadas, Panagiotis; Lascaratos, John

    2006-08-01

    The eminent doctor Constantin Levaditi represents one of the most important researchers in the field of medicine in the 20th century. Although he was engaged in many areas of the rapidly growing field of immunology, his name is associated mainly with research in poliomyelitis. His laboratory research contributed decisively to the clarification of the epidemiology of this dreadful disease that claimed thousands of victims. Moreover, his experimental work constituted the basis for the development of the vaccine against poliomyelitis, initially in 1955 by Jonas Salk (1914-95) using inactivated virus, and then in 1960 by Albert Sabin (1906-93) who used live attenuated virus.

  7. [Historical development of vaccines. Introduction: Hazards and rationality in the vaccinal approach].

    Science.gov (United States)

    Moulin, A M

    1995-01-01

    The aim of this paper is to introduce the one hundred years of vaccination that has passed since Louis Pasteur first coined this generic term. According to the late Jonas Salk, vaccinology is a science encompassing all aspects of vaccine from its conception in the laboratory to its production by companies and its application and distribution in the field. In this historical survey I explore how vaccination never consisted of a simple and uniform application of a rational model, but rather diverged along various pathways, several of which were discarded in retrospect as being hazardous, and I analyse the ongoing interplay between rational and inventive thinking.

  8. FDA advisory committees meet January 26 on Salk HIV-1 immunogen.

    Science.gov (United States)

    1995-01-06

    Two advisory committees of the Food and Drug Administration (FDA) will meet to consider future trials of the HIV-1 immunogen developed by Dr. Jonas Salk. The Immune Response Corporation has already conducted several studies of the immunogen, and has found improvement in various immunological and other blood tests, and no adverse effects. However, the studies have not been large enough to show conclusively that the treatment has clinical benefit in delaying disease progression. The new, larger trials are intended to demonstrate a delay in disease progression and validate the use of blood-test markers of disease progression for studying an immune-based treatment.

  9. Portrait

    OpenAIRE

    Granoff, Dan M.

    2013-01-01

    Born in 1944, I grew up in a world in which polio was both a gripping fear and real threat. Then in a matter of a few years—polio was eradicated by a vaccine developed by Jonas Salk. Later I learned that Salk’s efforts were built on pioneering work of many others, including John Enders, Thomas Weller and Frederick Robbins (Nobelists, 1954), and David Bodian, who pioneered studies of polio pathogenesis and immunity. Bodian became my teacher in medical school, and Robbins became a colleague. La...

  10. Dynamical Model of QCD Vacuum and Color Thaw at Finite Temperatures

    Institute of Scientific and Technical Information of China (English)

    WANGDian-Fu; SONGHe-Shan; MIDong

    2004-01-01

    In terms of the Nambu Jona-Lasinio (NJL) mechanism, the dynamical symmetry breaking of a simple local gauge model is investigated. An important relation between the vacuum expectation value of gauge fields and scalar fields is derived by solving the Euler equation for the gauge fields. Based on this relation the SU(3) gauge potential is given which can be used to explain the asymptotic freedom and confinement of quarks in a hadron. The confinement behavior at finite temperatures is also investigated and it is shown that color confinement at zero temperature can be melted away under high temperatures.

  11. Dynamical Model of QCD Vacuum and Color Thaw at Finite Temperatures

    Institute of Scientific and Technical Information of China (English)

    WANG Dian-Fu; SONG He-Shan; MI Dong

    2004-01-01

    In terms of the Nambu-Jona-Lasinio (NJL) mechanism, the dynamical symmetry breaking of a simple localgauge model is investigated. An important relation between the vacuum expectation value of gauge fields and scalarfields is derived by solving the Euler equation for the gauge fields. Based on this relation the SU(3) gauge potential isgiven which can be used to explain the asymptotic freedom and confinement of quarks in a hadron. The confinementbehavior at finite temperatures is also investigated and it is shown that color confinement at zero temperature can bemelted away under high temperatures.

  12. Ice limit of Coulomb gauge Yang-Mills theory

    International Nuclear Information System (INIS)

    Heinzl, T.; Ilderton, A.; Langfeld, K.; Lavelle, M.; McMullan, D.

    2008-01-01

    In this paper we describe gauge invariant multiquark states generalizing the path integral framework developed by Parrinello, Jona-Lasinio, and Zwanziger to amend the Faddeev-Popov approach. This allows us to produce states such that, in a limit which we call the ice limit, fermions are dressed with glue exclusively from the fundamental modular region associated with Coulomb gauge. The limit can be taken analytically without difficulties, avoiding the Gribov problem. This is illustrated by an unambiguous construction of gauge invariant mesonic states for which we simulate the static quark-antiquark potential.

  13. 2d Model Field Theories at Finite Temperature and Density

    OpenAIRE

    Schoen, Verena; Thies, Michael

    2000-01-01

    In certain 1+1 dimensional field theoretic toy models, one can go all the way from microscopic quarks via the hadron spectrum to the properties of hot and dense baryonic matter in an essentially analytic way. This "miracle" is illustrated through case studies of two popular large N models, the Gross-Neveu and the 't Hooft model - caricatures of the Nambu-Jona-Lasinio model and real QCD, respectively. The main emphasis will be on aspects related to spontaneous symmetry breaking (discrete or co...

  14. Lietuviško anatomijos vardyno istorijos metmenys

    OpenAIRE

    Česnys, Gintautas

    2002-01-01

    The history of Lithuanian anatomical terminology begins in 1620, when a Polish-Latin-Lithuanian dictionary by Konstantinas Sirvydas (1579-1631) was published. In the first publicistic writings in medicine, Vincas Kudirka (1858-1899) used some anatomical terms that have survived until now. Jonas Basanavičius (1851-1927) started the creation of Lithuanian medical nomenclature as a system. Between the two world wars, Jurgis Žilinskas (1885-1957) and his colleagues tried to unify the system, and ...

  15. Spinodal instability of baryon-rich quark matter

    International Nuclear Information System (INIS)

    Li, Feng; Ko, Che Ming

    2017-01-01

    The spinodal instabilities of both confined and expanding baryon-rich quark matters are studied in a transport model derived from the Nambu-Jona-Lasino model. Appreciable higher-order density moments are seen as a result of the first-order phase transition in both cases. The skewness of the quark number event-by-event distribution in a small subvolume of the system becomes appreciable for the confined quark matter. For the expanding quark matter, the density fluctuations lead to enhanced anisotropic flows and dilepton yield. (paper)

  16. On the form factors of the D+s → φ μ+ υμ decay

    International Nuclear Information System (INIS)

    Hussain, F.; Ivanov, A.N.; Troitskaya, N.I.

    1995-05-01

    We apply the infinite mass effective theory, when a heavy quark mass tends to infinity, and Chiral perturbation theory at the quark level, based on the extended Nambu - Jona - Lasinio model with linear realization of chiral U(3) x U(3) symmetry, to calculate the form factors of the D + s → φ μ + υ μ decay up to the first order in current s - quark mass. The theoretical results are compared with experimental data and found to be in good agreement. (author). 12 refs

  17. Dense baryon matter with isospin and chiral imbalance in the framework of a NJL4 model at large Nc: Duality between chiral symmetry breaking and charged pion condensation

    Science.gov (United States)

    Khunjua, T. G.; Klimenko, K. G.; Zhokhov, R. N.

    2018-03-01

    In this paper the phase structure of dense quark matter has been investigated at zero temperature in the presence of baryon, isospin and chiral isospin chemical potentials in the framework of massless (3 +1 )-dimensional Nambu-Jona-Lasinio model with two quark flavors. It has been shown that in the large-Nc limit (Nc is the number of colors of quarks) there exists a duality correspondence between the chiral symmetry breaking phase and the charged pion condensation one. The key conclusion of our studies is the fact that chiral isospin chemical potential generates charged pion condensation in dense quark matter with isotopic asymmetry.

  18. Quark self-energy beyond the mean field at finite temperature

    International Nuclear Information System (INIS)

    Zhuang, P.

    1995-01-01

    The Nambu--Jona-Lasinio model, an effective low-energy model of QCD, is extended to the next to the leading order in the 1/N c expansion at finite temperature and density. The contributions to the quark self-energy and the constituent quark mass from the meson dressing are considered in a perturbative approach about the mean field. In particular, the temperature dependence of the quark mass is shown numerically at zero chemical potential. The correction to the quark mass from the meson dressing amounts to 20% compared to the result of the leading order at low temperature, and rapidly approaches zero at high temperature

  19. Non-uniform chiral phase in effective chiral quark models

    International Nuclear Information System (INIS)

    Sadzikowski, M.; Broniowski, W.

    2000-01-01

    We analyze the phase diagram in effective chiral quark models (the Nambu-Jona-Lasinio model, the σ-model with quarks) and show that at the mean-field level a phase with a periodically-modulated chiral fields separates the usual phases with broken and restored chiral symmetry. A possible signal of such a phase is the production of multipion jets travelling in opposite directions, with individual pions having momenta of the order of several hundred MeV. This signal can be interpreted in terms of disoriented chiral condensates. (author)

  20. Chiral dynamics and heavy quark symmetry in a solvable toy field-theoretic model

    International Nuclear Information System (INIS)

    Bardeen, W.A.; Hill, C.T.

    1994-01-01

    We study a solvable QCD-like toy theory, a generalization of the Nambu--Jona-Lasinio model, which implements chiral symmetries of light quarks and heavy quark symmetry. The chiral symmetric and chiral broken phases can be dynamically tuned. This implies a parity-doubled heavy-light meson system, corresponding to a (0 - ,1 - ) multiplet and a (0 + ,1 + ) heavy spin multiplet. Consequently the mass difference of the two multiplets is given by a Goldberger-Treiman relation and g A is found to be small. The Isgur-Wise function ξ(w), the decay constant f B , and other observables are studied

  1. Description of hot compressed hadronic matter based on an effective chiral Lagrangian

    International Nuclear Information System (INIS)

    Florkowski, W.

    1996-11-01

    In this report we give the review of the recent results obtained in the Nambu-Jona-Lasinio (NJL) model, describing the properties of hot compressed matter. The first large class problems concerns the behaviour of static meson correlation functions. In particular, this includes the investigation of the screening of meson fields at finite temperature or density. Another wide range of problems presented in our report concerns the formulation of the transport theory for the NJL model and its applications to the description of high energy nuclear collision. 86 refs, 35 figs

  2. Nuclear phenomena derived from quark-gluon strings

    DEFF Research Database (Denmark)

    Bohr, Henrik; Providencia, Constanca; Providencia, Joao da

    2005-01-01

    provided that the chiral fields are identified with the two-particle strings, which are natural in a QCD framework. Moreover, the model is able to reconcile qualitatively such aspects of hadronic physics as saturation density and binding energy of nuclear matter, surface density of finite nuclei, mass......, for the occurrence of the phases of nuclear matter. The model exhibits a quark deconfinement transition and chiral restoration, which are ingredients of QCD and give qualitatively correct numerics. The effective model is shown to be isomorphic to the Nambu-Jona-Lasinio model and exhibits the correct chirality...

  3. Psychosomatic medicine and the philosophy of life

    OpenAIRE

    Wiggins Osborne P; Schwartz Michael A

    2010-01-01

    Abstract Basing ourselves on the writings of Hans Jonas, we offer to psychosomatic medicine a philosophy of life that surmounts the mind-body dualism which has plagued Western thought since the origins of modern science in seventeenth century Europe. Any present-day account of reality must draw upon everything we know about the living and the non-living. Since we are living beings ourselves, we know what it means to be alive from our own first-hand experience. Therefore, our philosophy of lif...

  4. Monte Carlo simulations of the NJL model near the nonzero temperature phase transition

    International Nuclear Information System (INIS)

    Strouthos, Costas; Christofi, Stavros

    2005-01-01

    We present results from numerical simulations of the Nambu-Jona-Lasinio model with an SU(2)xSU(2) chiral symmetry and N c = 4,8, and 16 quark colors at nonzero temperature. We performed the simulations by utilizing the hybrid Monte Carlo and hybrid Molecular Dynamics algorithms. We show that the model undergoes a second order phase transition. The critical exponents measured are consistent with the classical 3d O(4) universality class and hence in accordance with the dimensional reduction scenario. We also show that the Ginzburg region is suppressed by a factor of 1/N c in accordance with previous analytical predictions. (author)

  5. Jono Basanavičiaus pamokos

    OpenAIRE

    Grigaravičius, Algirdas

    2012-01-01

    Although it is difficult to reveal the extent of Jonas Basanavičius‘ accomplishments, their valuable significance can be clearly perceived. The passing time encourages to evaluate everything as quickly and as concisely as possible, but also poses a threat that such urgency can result in yet one more monumental inscription. Doctor J. Basanavičius‘ work has been more or less evaluated in folklore, anthropology, mythology areas; the publishing of “Aušra“ [The Dawn], organization of the Great Ass...

  6. Baryon octet electromagnetic form factors in a confining NJL model

    Directory of Open Access Journals (Sweden)

    Manuel E. Carrillo-Serrano

    2016-08-01

    Full Text Available Electromagnetic form factors of the baryon octet are studied using a Nambu–Jona-Lasinio model which utilizes the proper-time regularization scheme to simulate aspects of colour confinement. In addition, the model also incorporates corrections to the dressed quarks from vector meson correlations in the t-channel and the pion cloud. Comparison with recent chiral extrapolations of lattice QCD results shows a remarkable level of consistency. For the charge radii we find the surprising result that rEp

  7. Transversity quark distributions in a covariant quark-diquark model

    Energy Technology Data Exchange (ETDEWEB)

    Cloet, I.C. [Physics Division, Argonne National Laboratory, Argonne, IL 60439-4843 (United States)], E-mail: icloet@anl.gov; Bentz, W. [Department of Physics, School of Science, Tokai University, Hiratsuka-shi, Kanagawa 259-1292 (Japan)], E-mail: bentz@keyaki.cc.u-tokai.ac.jp; Thomas, A.W. [Jefferson Lab, 12000 Jefferson Avenue, Newport News, VA 23606 (United States); College of William and Mary, Williamsburg, VA 23187 (United States)], E-mail: awthomas@jlab.org

    2008-01-17

    Transversity quark light-cone momentum distributions are calculated for the nucleon. We utilize a modified Nambu-Jona-Lasinio model in which confinement is simulated by eliminating unphysical thresholds for nucleon decay into quarks. The nucleon bound state is obtained by solving the relativistic Faddeev equation in the quark-diquark approximation, where both scalar and axial-vector diquark channels are included. Particular attention is paid to comparing our results with the recent experimental extraction of the transversity distributions by Anselmino et al. We also compare our transversity results with earlier spin-independent and helicity quark distributions calculated in the same approach.

  8. Medium modifications of nucleon electromagnetic form factors

    Energy Technology Data Exchange (ETDEWEB)

    Horikawa, T. [Department of Physics, School of Science, Tokai University, Hiratsuka-shi, Kanagawa 259-1292 (Japan); Bentz, W. [Department of Physics, School of Science, Tokai University, Hiratsuka-shi, Kanagawa 259-1292 (Japan)]. E-mail: bentz@keyaki.cc.u-tokai.ac.jp

    2005-11-28

    We use the Nambu-Jona-Lasinio model as an effective quark theory to investigate the medium modifications of the nucleon electromagnetic form factors. By using the equation of state of nuclear matter derived in this model, we discuss the results based on the naive quark-scalar diquark picture, the effects of finite diquark size, and the meson cloud around the constituent quarks. We apply this description to the longitudinal response function for quasielastic electron scattering. RPA correlations, based on the nucleon-nucleon interaction derived in the same model, are also taken into account in the calculation of the response function.

  9. Textkritische Edition der Übersetzung des Psalters in die Litauische Sprache von Johannes Bretke, Pastor zu Labiau und Königsberg i. Pr., nach der Handschrift aus dem Jahre 1580 [...

    OpenAIRE

    Gelumbeckaitė, Jolanta

    2003-01-01

    The review discusses the historical critical edition of the Psalm Book translated into Lithuanian by Jonas Bretkūnas in 1580 prepared by Friedrich Scholz, Professor Emeritus at Münster University. This is the first textologically diplomatically in corpore published volume of the Bible manuscript by Bretkūnas (1579–1590) and the first critical edition of the 16th c. Lithuanian manuscript text. The critical edition of the Psalm Book is part of a large Bretkūnas’ Bible publishing project, consis...

  10. Improving nursing morale in a climate of cost containment. Part 1. Organizational assessment.

    Science.gov (United States)

    Haw, M A; Claus, E G; Durbin-Lafferty, E; Iversen, S M

    1984-10-01

    Faced with declining resources for health care and greater pressures to improve productivity of nursing staff, nursing administrators must act now to develop organizational responses to morale problems among nursing staff. As part of a two-part series for JONA, the authors describe low-cost organizational approaches that address nursing morale. Presented in Part 1 is a low-cost diagnostic process for assessing needs of staff and appraising organizational dimensions contributing to morale. Assessment findings provide clear direction for developing organizational approaches for improving morale.

  11. [Improving job morale of nurses despite insurance cost control. 1: Organization assessment].

    Science.gov (United States)

    Haw, Mary Ann; Claus, Eleanor G; Durbin-Lafferty, Ellen; Iversen, Sharon M

    2003-04-01

    Faced with declining resources for health care and greater pressures to improve productivity of nursing staff, nursing administrators must act now to develop organizational responses to morale problems among nursing staff. As part of a two-part series for JONA, the authors describe low-cost organizational approaches that address nursing morale. Presented in Part 1 is a low-cost diagnostic process for assessing needs of staff and appraising organizational dimensions contributing to morale. Assessment findings provide clear direction for developing organizational approaches for improving morale.

  12. Current s - quark mass corrections to the form factors of D - meson semileptonic decays

    International Nuclear Information System (INIS)

    Hussain, F.; Ivanov, A.N.; Troitskaya, N.I.

    1994-11-01

    The infinite mass effective theory, when a heavy quark mass tends to infinity, and Chiral perturbation theory at the quark level, based on the extended Nambu - Jona - Lasinio model with linear realization of chiral U(3) x U(3) symmetry, are applied to the calculations of current s - quark mass corrections to the form factors of the D → K-bar e + ν e and D → K-bar * e + ν e decays. These corrections turn out to be quite significant, of the order of 7 - 20%. The theoretical results are compared with experimental data. (author). 17 refs

  13. A Generalized Yang-Mills Model and Dynamical Breaking of Gauge Symmetry

    International Nuclear Information System (INIS)

    Wang Dianfu; Song Heshan

    2005-01-01

    A generalized Yang-Mills model, which contains, besides the vector part V μ , also a scalar part S, is constructed and the dynamical breaking of gauge symmetry in the model is also discussed. It is shown, in terms of Nambu-Jona-Lasinio (NJL) mechanism, that the gauge symmetry breaking can be realized dynamically in the generalized Yang-Mills model. The combination of the generalized Yang-Mills model and the NJL mechanism provides a way to overcome the difficulties related to the Higgs field and the Higgs mechanism in the usual spontaneous symmetry breaking theory.

  14. Tres enfoques Deontológicos Acerca de la Vida

    Directory of Open Access Journals (Sweden)

    Edgar Antonio López

    2007-01-01

    Full Text Available Este artículo presenta tres aproximaciones deontológicas a algunos problemas referidos al comienzo, el fin y la reproducción de la vida humana, así como a la preservación de la vida -humana y no humana- en el planeta. En primer lugar se presenta la deontología clásica de Kant y luego las deontologías contemporáneas de Hans Jonas y de Jürgen Habermas.

  15. Heavy hybrid stars from multi-quark interactions

    International Nuclear Information System (INIS)

    Benic, Sanjin

    2014-01-01

    We explore the possibility of obtaining heavy hybrid stars within the framework of the two flavor Nambu-Jona-Lasinio model that includes 8-quark interactions in the scalar and in the vector channel. The main impact of the 8-quark scalar channel is to reduce the onset of quark matter, while the 8-quark vector channel acts to stiffen the equation of state at high densities. Within the parameter space where the 4-quark vector channel is small, and the 8-quark vector channel sizeable, stable stars with masses of 2 M ⊙ and above are found to hold quark matter in their cores. (orig.)

  16. Education, learning and participation (FERA 50 years anniversary - celebrating with colleagues)

    DEFF Research Database (Denmark)

    Lysgaard, Jonas Andreasen

    The second presentation on participation by Jonas Andreasen Lysgaard will address different takes on participation in learning, particularly those informed by critical educational theory and sociocultural theory of learning. The focus will be on the tensions between the normative and transformative...... on the one side and the discursive and transcendental on the other. Drawing on a Lacanian perspective the key argument is that although participation as an educational ideal cannot be fully reached, or measured, it nevertheless holds significance as an organizing principle of the pedagogical practice....

  17. Effects of a multi-quark interaction on color superconducting phase transition in an extended NJL model

    International Nuclear Information System (INIS)

    Kashiwa, Kouji; Matsuzaki, Masayuki; Kouno, Hiroaki; Yahiro, Masanobu

    2007-01-01

    We study the interplay of the chiral and the color superconducting phase transition in an extended Nambu-Jona-Lasinio model with a multi-quark interaction that produces the nonlinear chiral-diquark coupling. We observe that this nonlinear coupling adds up coherently with the ω 2 interaction to either produce the chiral-color superconductivity coexistence phase or cancel each other depending on its sign. We discuss that a large coexistence region in the phase diagram is consistent with the quark-diquark picture for the nucleon whereas its smallness is the prerequisite for the applicability of the Ginzburg-Landau approach

  18. Abnormal number of Nambu-Goldstone bosons in the color-asymmetric 2SC phase of an NJL-type model

    OpenAIRE

    Blaschke, D.; Ebert, D.; Klimenko, K. G.; Volkov, M. K.; Yudichev, V. L.

    2004-01-01

    We consider an extended Nambu--Jona-Lasinio model including both (q \\bar q)- and (qq)-interactions with two light-quark flavors in the presence of a single (quark density) chemical potential. In the color superconducting phase of the quark matter the color SU(3) symmetry is spontaneously broken down to SU(2). If the usual counting of Goldstone bosons would apply, five Nambu-Goldstone (NG) bosons corresponding to the five broken color generators should appear in the mass spectrum. Unlike that ...

  19. Structure functions from chiral soliton models

    International Nuclear Information System (INIS)

    Weigel, H.; Reinhardt, H.; Gamberg, L.

    1997-01-01

    We study nucleon structure functions within the bosonized Nambu-Jona-Lasinio (NJL) model where the nucleon emerges as a chiral soliton. We discuss the model predictions on the Gottfried sum rule for electron-nucleon scattering. A comparison with a low-scale parametrization shows that the model reproduces the gross features of the empirical structure functions. We also compute the leading twist contributions of the polarized structure functions g 1 and g 2 in this model. We compare the model predictions on these structure functions with data from the E143 experiment by GLAP evolving them from the scale characteristic for the NJL-model to the scale of the data

  20. Notes from the church of the Virgin at the island of Mali grad

    Directory of Open Access Journals (Sweden)

    Cvetkovski Sašo

    2010-01-01

    Full Text Available In this text the unknown parts of the wall paintings from the Church of the Virgin at the island of Mali Grad (The Great Prespa Lake are analyzed: the figure of a monk praying to St. Paraskeve, on the southern wall of the nave, as well as the painting on the southern faüade with the depictions of St. George on horseback, the Virgin as Empress enthroned, and the bust of two saints, St. Paraskeve and St. Nicholas. The monk is identified with the hegoumenos Jona, mentioned in the donor’s inscription dating from 1369.

  1. Singular charge density at the center of the pion?

    International Nuclear Information System (INIS)

    Miller, Gerald A.

    2009-01-01

    We relate the three-dimensional infinite momentum frame spatial charge density of the pion to its electromagnetic form factor F π (Q 2 ). Diverse treatments of the measured form factor data including phenomenological fits, nonrelativistic quark models, the application of perturbative quantum chromodynamics (QCD), QCD sum rules, holographic QCD, and the Nambu-Jona-Lasinio (NJL) model all lead to the result that the charge density at the center of the pion has a logarithmic divergence. Relativistic constituent quark models do not display this singularity. Future measurements planned for larger values of Q 2 may determine whether or not a singularity actually occurs.

  2. [Crisis in medical ethics].

    Science.gov (United States)

    Stellamor, K

    1996-01-01

    There is a disproportion between diagnostic and therapeutic medical achievements and the doctor/patient relationship. Are we allowed to do everything we are able to do in medicine? People are concerned and worried (genetic technology, invasive medicine, embryos in test tubes etc.). The crisis of ethics in medicine is evident. The analysis of the situation shows one of the causes in the shift of the paradigma-modern times to postmodern following scientific positivism-but also a loss of ethics in medicine due to an extreme secularism and to modern philosophical trends (Hans Jonas and the responsibility for the future and on the other hand modern utilitarism).

  3. A chiral model for excited pions

    International Nuclear Information System (INIS)

    Volkov, M.K.; Weiss, C.

    1996-01-01

    We study radially excited mesons (π', σ') in a simple extension of the Nambu-Jona-Lasinio model with a polynomial meson-quark form factor. The form factor is introduced so that the usual form of the NJL gap equation remains unchanged. We derive the effective Lagrangian for π- and π'-mesons which describes the decoupling of the Goldstone pion in the chiral limit in agreement with current algebra. For π' masses in the range of 750 MeV and 1300 MeV f π' /f π is found to be of an order of one per cent. 12 refs

  4. Scalar mesons and glueballs in a chiral U(3)xU(3) quark model with 't Hooft interaction

    International Nuclear Information System (INIS)

    Nagy, M.; Volkov, M.K.; Yudichev, V.L.

    2000-01-01

    In a U(3)xU(3) quark chiral model of the Nambu-Jona-Lasino (NJL) type with the 't Hooft interaction, the ground scalar isoscalar mesons and a scalar glueball are described. The glueball (dilaton) is introduced into the effective meson Lagrangian written in a chirally symmetric form on the basis of scale invariance. The singlet-octet mixing of scalar isoscalar mesons and their mixing with the glueball are taken into account. Mass spectra of the scalar mesons and glueball and their strong decays are described

  5. Ethik der Verantwortung: Begründungsprobleme aus diskursethischer Sicht

    Directory of Open Access Journals (Sweden)

    Holger Burckhart

    2012-12-01

    Full Text Available - Ethic of responsibility. Foundation problems from the point of view of discourse ethics - This paper discusses the problem of the foundation of the ethics of responsibility in Hans Jonas by the point of view of the Karl-Otto Apel’s discourse ethics. In difference to a unilateral reciprocal ethics – like christians charity, ethics of the bond in the kantian sense, ethics of the face according to Levinas, ethics I-You according to Buber – the approach proposed in this paper can be defined as universal reciprocal. This means that it need to consider the interests of all participants in the “life”.

  6. Relics of a Benedictine Legendary in Scandinavia? Notes on fragments nos. 527-529 from the Royal Library and no. 8302 from the Danish National Archives

    DEFF Research Database (Denmark)

    Troelsgård, Christian

    2007-01-01

    as originating from the same codex. Codicological and palaeographical analysis places this codex with hagiographical contents (Bede's prosi-metric life of St Cuthbert and Jonas of Bobbio's account of St. Columban) in the years around 1200. Philological analysis links the version of Bede's life of St Cuthbert...... to a continental tradition rather than directly to an English model. Finally, on the basis of the analysis of the fragments themselves and the circumstances connected with their recycling as covers for the royal customs accounts of Malmø in 1628 it is suggested that the Cluniac monastery of All Saints at Lund...

  7. Towards Ethical Business

    OpenAIRE

    László Zsolnai

    2003-01-01

    Business activities considerably affect the fate and survival of natural ecosystems as well as the life conditions of present and future generations. In the light of Hans Jonas' theory of responsibility we can state that business has a one-way, non-reciprocal duty caring for the beings affected by its functioning. To become a fully ethical enterprise, business is to be carried out in sustainable, pro-social and future enhancing ways. Doing ethical business is not a luxury of advanced societie...

  8. The underside of technological-scientific societies

    International Nuclear Information System (INIS)

    Grandazzi, Guillaume

    2006-01-01

    After having recalled how the critic of technique or the catastrophe have been thought and discussed by philosophers like Heidegger, Jonas or Arendt, and while referring to other authors (Dupuy, Castoriadis, and so on), the author discusses the evolution from a situation of risk to a situation of vulnerability, comments the philosophical and societal impact of nuclear from Hiroshima to Chernobyl. He evokes the issue of how to move beyond the opposition between naturalism and humanism, and discusses the emergence of a 'culture of the after-catastrophe'

  9. Chiral symmetry breaking in a semilocalized magnetic field

    Science.gov (United States)

    Cao, Gaoqing

    2018-03-01

    In this work, we explore the pattern of chiral symmetry breaking and restoration in a solvable magnetic field configuration within the Nambu-Jona-Lasinio model. The special semilocalized static magnetic field can roughly mimic the realistic situation in peripheral heavy ion collisions; thus, the study is important for the dynamical evolution of quark matter. We find that the magnetic-field-dependent contribution from discrete spectra usually dominates over the contribution from continuum spectra and chiral symmetry breaking is locally catalyzed by both the magnitude and scale of the magnetic field. The study is finally extended to the case with finite temperature or chemical potential.

  10. Isospin breaking in nuclear physics: The Nolen-Schiffer effect

    International Nuclear Information System (INIS)

    Adami, C.; Brown, G.E.

    1991-01-01

    Using the QCD sum rules we calculate the neutron-proton mass difference at zero density as a function of the difference in bare quark mass m d -m u . We confirm results of Hatsuda, Hoegaasen and Prakash that the largest term results from the difference in up and down quark condensates, the explicit C (m d -m u ) entering with the opposite sign. The quark condensates are then extended to finite density to estimate the Nolen-Schiffer effect. The neutron-proton mass difference is extremely density dependent, going to zero at roughly nuclear matter density. The Ioffe formula for the nucleon mass is interpreted as a derivation, within the QCD sum rule approach, of the Nambu-Jona-Lasinio formula. This clarifies the N c counting and furthermore provides an alternative interpretation of the Borel mass. We compare calculations in the constituent quark model treated in the Nambu-Jona-Lasinio formalism with ours in the QCD sum rule approach. (orig.)

  11. Principios bioéticos en salud pública: limitaciones y propuestas

    Directory of Open Access Journals (Sweden)

    Fermin Roland Schramm

    2001-08-01

    Full Text Available Este artículo intenta caracterizar la especificidad de los problemas morales en salud pública y analizar la aplicabilidad del modelo principialista como padrón para dirimir sus conflictos. Aunque considerado pertinente para la bioética clínica, este modelo no es aplicable sin más a los dilemas en salud pública, puesto que se fundamenta en la moral de las interrelaciones médico-paciente. Se analiza la pertinencia de los principios de "solidaridad", de "responsabilidad óntica" según Jonas, y de "responsabilidad diacónica" según Lévinas, destacando la inaplicabilidad del primero y la posible adaptación de los otros dos a la salud pública. A ese respecto se discute la posibilidad de vincular la preocupación ontológica de Jonas y la trascendental de Lévinas, proponiendo un principio de protección que sería más adecuado a los propósitos de una ética de la salud pública, permitiendo identificar claramente los objetivos y los actores implicados en una implementación de políticas públicas moralmente correctas y pragmáticamente efectivas.

  12. What ecologists can tell virologists.

    Science.gov (United States)

    Dennehy, John J

    2014-01-01

    I pictured myself as a virus…and tried to sense what it would be like. --Jonas Salk. Ecology as a science evolved from natural history, the observational study of the interactions of plants and animals with each other and their environments. As natural history matured, it became increasingly quantitative, experimental, and taxonomically broad. Focus diversified beyond the Eukarya to include the hidden world of microbial life. Microbes, particularly viruses, were shown to exist in unfathomable numbers, affecting every living organism. Slowly viruses came to be viewed in an ecological context rather than as abstract, disease-causing agents. This shift is exemplified by an increasing tendency to refer to viruses as living organisms instead of inert particles. In recent years, researchers have recognized the critical contributions of viruses to fundamental ecological processes such as biogeochemical cycling, competition, community structuring, and horizontal gene transfer. This review describes virus ecology from a virus's perspective. If we are, like Jonas Salk, to imagine ourselves as a virus, what kind of world would we experience?

  13. Dynamically broken gauge model without fundamental scalar fields

    International Nuclear Information System (INIS)

    Snyderman, N.J.; Guralnik, G.S.

    1976-01-01

    It is shown that the structure that must be generated by dynamical symmetry breaking solutions to gauge theories can be explicitly implemented with a 4-fermion interaction. This structure arises in order to obtain consistency with the constraints imposed by a Goldstone commutator proportional to [anti psi psi]. One demonstrates these ideas within the context of axial electrodynamics, dynamically breaking chiral symmetry. As a pre-requisite it is shown how the Nambu-Jona-Lasinio model becomes renormalizable with respect to a systematic approximation scheme that respects the Goldstone commutator of dynamically broken chiral symmetry to each order of approximation. (This approximation scheme is equivalent to a l/N expansion, where N is set to unity at the end of the calculations). This solution generates new interactions not explicitly present in the original Lagrangian and does not have a 4-fermion contact interaction. The renormalized Green's functions are shown to correspond to those of the sigma-model, summed as though the fermions had N components, and for which lambda 0 = 2g 0 2 . This correspondence is exact except for the possibility that the renormalized coupling of the Nambu-Jona-Lasinio model may be a determined number

  14. Dynamically broken gauge model without fundamental scalar fields

    Energy Technology Data Exchange (ETDEWEB)

    Snyderman, N. J.; Guralnik, G. S.

    1976-01-01

    It is shown that the structure that must be generated by dynamical symmetry breaking solutions to gauge theories can be explicitly implemented with a 4-fermion interaction. This structure arises in order to obtain consistency with the constraints imposed by a Goldstone commutator proportional to (anti psi psi). One demonstrates these ideas within the context of axial electrodynamics, dynamically breaking chiral symmetry. As a pre-requisite it is shown how the Nambu-Jona-Lasinio model becomes renormalizable with respect to a systematic approximation scheme that respects the Goldstone commutator of dynamically broken chiral symmetry to each order of approximation. (This approximation scheme is equivalent to a l/N expansion, where N is set to unity at the end of the calculations). This solution generates new interactions not explicitly present in the original Lagrangian and does not have a 4-fermion contact interaction. The renormalized Green's functions are shown to correspond to those of the sigma-model, summed as though the fermions had N components, and for which lambda/sub 0/ = 2g/sub 0//sup 2/. This correspondence is exact except for the possibility that the renormalized coupling of the Nambu-Jona-Lasinio model may be a determined number.

  15. Fierz-complete NJL model study: Fixed points and phase structure at finite temperature and density

    Science.gov (United States)

    Braun, Jens; Leonhardt, Marc; Pospiech, Martin

    2017-10-01

    Nambu-Jona-Lasinio-type models are frequently employed as low-energy models in various research fields. With respect to the theory of the strong interaction, this class of models is indeed often used to analyze the structure of the phase diagram at finite temperature and quark chemical potential. The predictions from such models for the phase structure at finite quark chemical potential are of particular interest as this regime is difficult to access with lattice Monte Carlo approaches. In this work, we consider a Fierz-complete version of a Nambu-Jona-Lasinio model. By studying its renormalization group flow, we analyze in detail how Fierz-incomplete approximations affect the predictive power of such model studies. In particular, we investigate the curvature of the phase boundary at small chemical potential, the critical value of the chemical potential above which no spontaneous symmetry breaking occurs, and the possible interpretation of the underlying dynamics in terms of difermion-type degrees of freedom. We find that the inclusion of four-fermion channels other than the conventional scalar-pseudoscalar channel is not only important at large chemical potential but also leaves a significant imprint on the dynamics at small chemical potential as measured by the curvature of the finite-temperature phase boundary.

  16. Food marketing targeting children: unveiling the ethical perspectives in the discourse on self-regulation.

    Science.gov (United States)

    Silva, Dillian Adelaine Cesar da; Cunha, Antonio Carlos Rodrigues da; Cunha, Thiago Rocha da; Rosaneli, Caroline Filla

    2017-07-01

    When it comes to food marketing, children are one of the major targets. Regulatory actions can play a strategic role in health protection. The objective of this research was to characterize the ethical perspective in the discourse against state regulatory actions on food marketing directed at children, aiming to understand the context of the discourse's production and how it creates meaning. The methodology adopted was qualitative, with documentary analysis and use of concepts and procedures from Discourse Analysis. The work of Hans Jonas, specifically his Responsibility Principle, and Garrafa and Port's Intervention Bioethics oriented the analysis. The self-regulation discourse analysis showed an ethical perspective in which relations of consumption predominate over the children´s vulnerability. The rhetorical excess is constant, as well as the use of resources like naturalization, untruthfulness, ideological dissimulation and euphemism. An erasure of social conflicts takes place, and an ahistorical perspective is present. The discourse does not align with Jonas´ Responsibility Principle, nor those of Intervention Bioethics. Lastly, the ethical perspective of the discourse represents a double paradox, because it is a business discourse that hides its competitive roots and metamorphoses into an ethical one.

  17. INHUMAN HUMAN NATURE: LOIS LOWRY’S THE GIVER

    Directory of Open Access Journals (Sweden)

    Oznur Cengiz

    2017-06-01

    Full Text Available Lois Lowry (1937- is a prolific author having a number of books – Number the Stars (1989, Gathering Blue (2000, and Messenger (2004 – and awards especially in the field of children’s literature. Her significant science fiction novel, The Giver (1993, presents a social panorama in order to thoroughly analyze the society’s mechanical life style. As an example of dystopia, the author delineates a systematically organized social order where people abide by the rules naturally. Nevertheless, Jonas, the protagonist and Receiver of Memory, is the first person to discern robotic/mechanical order in the society which is transformed into “sameness” eliminating all individual differences and emotions such as pain, happiness, cold, colors, and so on. Therefore, Receiver of Memory storing past memories of the society is the only one who is aware of human characteristics. The crucial point is that human figure, far from the current one, displays inhuman (non-human features without memories and hope. Mechanical association between individuals and social structure ascertains artificial form of life in which there is no chance to choose. After learning truths behind the strict order, Jonas is in pursuit of real world with all kinds of feelings; however, his recognition is not able to change the whole society. Hence, this paper aims at delving into the relationship between human nature and society with regard to posthuman approach and inhuman human form in accordance with transformation of human nature.

  18. Quark fragmentation functions in NJL-jet model

    Science.gov (United States)

    Bentz, Wolfgang; Matevosyan, Hrayr; Thomas, Anthony

    2014-09-01

    We report on our studies of quark fragmentation functions in the Nambu-Jona-Lasinio (NJL) - jet model. The results of Monte-Carlo simulations for the fragmentation functions to mesons and nucleons, as well as to pion and kaon pairs (dihadron fragmentation functions) are presented. The important role of intermediate vector meson resonances for those semi-inclusive deep inelastic production processes is emphasized. Our studies are very relevant for the extraction of transverse momentum dependent quark distribution functions from measured scattering cross sections. We report on our studies of quark fragmentation functions in the Nambu-Jona-Lasinio (NJL) - jet model. The results of Monte-Carlo simulations for the fragmentation functions to mesons and nucleons, as well as to pion and kaon pairs (dihadron fragmentation functions) are presented. The important role of intermediate vector meson resonances for those semi-inclusive deep inelastic production processes is emphasized. Our studies are very relevant for the extraction of transverse momentum dependent quark distribution functions from measured scattering cross sections. Supported by Grant in Aid for Scientific Research, Japanese Ministry of Education, Culture, Sports, Science and Technology, Project No. 20168769.

  19. Heideggerius gnosticus? El sentido del recurso heideggeriano a la divinidad

    Directory of Open Access Journals (Sweden)

    ENZO SOLARI

    2008-01-01

    Full Text Available Este trabajo pregunta por el sentido del complejo y peculiar recurso heideggeriano a la divinidad. Deteniéndose particularmente en la interpretación de Jonas, argumenta que el gnosticismo es solo muy aproximadamente afín al pensamiento de Heidegger. Y sugiere que podría encontrarse una mejor analogía para este pensamiento en la polémica que enfrentó al cristianismo gnóstico con el eclesiástico, aunque esto también sea una gruesa aproximación que deja abiertas otras posibilidades interpretativas.This paper deals with the sense of the complex and peculiar Heideggerian resource to divinity. Analyzing particularly, the interpretation of Jonas, it argües that the Gnosticism is only very approximately compatible to the thought of Heidegger. And it suggests that could be found a better analogy for this thought, in the controversy that faced the Gnostic Christianity with the Ecclesiastic, although this is also a thick approximation that leaves other interpretative possibilities open.

  20. Principios bioéticos en salud pública: limitaciones y propuestas

    Directory of Open Access Journals (Sweden)

    Schramm Fermin Roland

    2001-01-01

    Full Text Available Este artículo intenta caracterizar la especificidad de los problemas morales en salud pública y analizar la aplicabilidad del modelo principialista como padrón para dirimir sus conflictos. Aunque considerado pertinente para la bioética clínica, este modelo no es aplicable sin más a los dilemas en salud pública, puesto que se fundamenta en la moral de las interrelaciones médico-paciente. Se analiza la pertinencia de los principios de "solidaridad", de "responsabilidad óntica" según Jonas, y de "responsabilidad diacónica" según Lévinas, destacando la inaplicabilidad del primero y la posible adaptación de los otros dos a la salud pública. A ese respecto se discute la posibilidad de vincular la preocupación ontológica de Jonas y la trascendental de Lévinas, proponiendo un principio de protección que sería más adecuado a los propósitos de una ética de la salud pública, permitiendo identificar claramente los objetivos y los actores implicados en una implementación de políticas públicas moralmente correctas y pragmáticamente efectivas.

  1. 山西省襄垣县2009~2015年农村女性宫颈癌筛查项目结果分析%Results of Cervical Cancer Screening Program for Rural Women in Xiangyuan County During 2009 to 2015

    Institute of Scientific and Technical Information of China (English)

    史少东; 贾萌萌; 王少明; 王莉; 李旭亮; 苏采峰; 石艳梅; 郝燕; 乔友林

    2017-01-01

    [目的]通过分析襄垣县2009~2015年农村妇女宫颈癌筛查结果,为国家宫颈癌筛查项目的评价和优化提供理论依据.[方法]对襄垣县35~64岁妇女开展宫颈癌筛查.2009~2013年采用醋酸/碘染色后肉眼观察(VIA/VILI),2014年开始部分引入人乳头状瘤病毒(HPV)检测,2015年又引入新柏氏液基细胞学(TCT)检测,根据卫生资源情况在不同人群中分别使用三种方法.任意筛查结果阳性者转诊阴道镜,镜下有病变时取活检,以病理诊断为金标准.通过评价不同方法对宫颈上皮内瘤变(CIN)2级及以上病变的检出率评价不同方法对宫颈癌的筛查效果.[结果] 2009~2015年共筛查62 618名女性,其中CIN2级及以上(CIN2+)病变的患病率为0.76%,早诊率为90.53%,下生殖道感染率为25.68%,其中滴虫性阴道炎、细菌性阴道炎和宫颈炎与HPV感染相关.根据2014及2015年数据,VIA/VILI的CIN2+病变检出率为0.74%,TCT的病变检出率为0.70%,两者相似,但均低于HPV检测,其病变检出率为1.37%.[结论]HPV检测是首选的宫颈癌初筛方法,在资源匮乏地区,培训合格的基层医生使用VIA/VILI或TCT方法对适龄妇女开展宫颈癌筛查是有效的备选方案.%[Purpose] To analyze the results of Cervical Cancer Screening Program for Rural Women in Xiangyuan county,Shanxi province during 2009 to 2015.[Methods] According to the protocol of the National Cervical Cancer Screening Program in Rural China,women aged 35 to 64 in Xiangyuan county were recruited for screening.Visual inspection with acetic acid and Lugol's iodine(VIA/VILI) was used in 2009 to 2013,human papillomavirus(HPV) DNA test was introduced in 2014 and then thin-Prep cytology(TCT) was introduced in 2015.Colposcopic examination was performed if the result was positive.Cervical lesions were diagnosed by direct biopsy under the colposcopy,and the pathological diagnosis was used for gold standard.The screening effectiveness was

  2. Entendendo os mecanismos determinantes da lesão pulmonar induzida pela ventilação mecânica Understanding the mechanisms of ventilator-induced lung injury

    Directory of Open Access Journals (Sweden)

    Liliane M. Nardelli

    2007-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A ventilação mecânica é considerada elemento básico de suporte de vida nas unidades de terapia intensiva e, indubitavelmente, essencial para os pacientes com lesão pulmonar aguda (LPA e síndrome do desconforto respiratório agudo (SDRA. Estudos experimentais demonstraram que a ventilação mecânica (VM com altos volumes e/ou altas pressões pode exacerbar ou iniciar uma lesão pulmonar, denominada lesão pulmonar associada à VM (LPAV ou lesão pulmonar induzida pelo ventilador (LPIV, respectivamente, com aspecto histológico similar ao da LPA/SDRA. CONTEÚDO: Realizou-se uma pesquisa sistemática dos artigos incluídos na MedLine e SciElo dos últimos 20 anos, que abordavam uma visão crítica dos principais mecanismos determinantes da LPIV. Dentre os principais mecanismos da LPAV/LPIV pode-se citar: volutrauma causado por hiperdistensão e expansão desigual das unidades alveolares em função de altas pressões transpulmonares ou volumes; aletectrauma resultante da abertura e fechamento cíclicos das vias aéreas distais e o biotrauma determinado pelo processo inflamatório conseqüente às estratégias ventilatórias lesivas adotadas. CONCLUSÕES: Os mecanismos responsáveis pelo volutrauma, atelectrauma e biotrauma devem ser bem entendidos para que se possa evitar a lesão associada à ventilação mecânica.BACKGROUND AND OBJECTIVES: Mechanical ventilation is considered a basic element of life support in the intensive care unit and is essential for patients with acute lung injury (ALI and acute respiratory distress syndrome (ARDS. Experimental studies have demonstrated that mechanical ventilation with high volumes and/or high pressures can exacerbate (VALI or induce lung injury (VILI with histological aspect similar to ALI/ARDS. CONTENTS: This systematic review included the literature on MedLine and SciElo database published in the last 20 years. In this review, we will highlight the most recent data on

  3. COLPOSCOPY- A PRIMARY ALTERNATIVE SCREENING TOOL FOR CERVICAL PRE-CANCER

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    Srinivas Sangisapu

    2017-09-01

    Full Text Available BACKGROUND Cancer cervix is the most common and preventable malignancy in females. 80% of cases in India are detected in advanced stages. Paucity of cytologists in India is one of the important reasons for failure of screening by Pap smear. Visual Inspection of cervix with Acetic acid (VIA and Visual Inspection of cervix with application of Lugol’s Iodine (VILI are two alternative strategies in low resource settings. Colposcopy involves the same principles of VIA and VILI under better magnification. We have hospitals with not so low resource settings, where gynaecologists are available, but cytologists are not. We need to evolve an alternative strategy appropriate to our resources such as colposcopy and guided biopsy. The aim of the present study is to evaluate the feasibility of colposcopy as an alternative screening tool for cervical precancer. The objective of the study is therefore to compare the colposcopy with the known reference standard that is Pap smear and evaluate the sensitivity, specificity and predictive values. MATERIALS AND METHODS 3000 women were compared with simultaneous colposcopy and Pap smear with latter as reference standard. Colposcopy-guided cervical biopsy was performed for suspicious lesions. RESULTS Unsatisfactory colposcopy due to nonvisualisation of transformation zone is an insignificant percentage (1.7%. The sensitivity, specificity, positive and negative predictive values of colposcopy for the threshold of normal versus all grades of abnormality (all age groups and all abnormal reports included are 76.74%, 99.34%, 63.46% and 99.65%, respectively. Pap smear is taken as a reference standard. This is the primary objective of our study. Colposcopy-guided biopsy specimens of minor abnormal colposcopic lesions falling outside the transformation zone have not yielded any abnormal findings on histopathology. Three high-grade lesions were detected by colposcopy as well as Pap smear. They have also positively

  4. Early detection of cervical cancer with visual inspection methods: a summary of completed and on-going studies in India

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    Sankaranarayanan R

    2003-01-01

    Full Text Available India is a high-risk country for cervical cancer which accounts a quarter (126 000 new cases, 71 000 deaths around 2 000 of the world burden. The age-standardized incidence rates range from 16-55 per 100 000 women in different regions with particularly high rates in rural areas. Control of cervical cancer by early detection and treatment is a priority of the National Cancer Control Programme of India. There are no organized cytology screening programmes in the country. The technical and financial constraints to organize cytology screening have encouraged the evaluation of visual inspection approaches as potential alternatives to cervical cytology in India. Four types of visual detection approaches for cervical neoplasia are investigated in India: a naked eye inspection without acetic acid application, widely known as 'downstaging'; b naked eye inspection after application of 3-5% acetic acid (VIA; c VIA using magnification devices (VIAM; d visual inspection after the application of Lugol's iodine (VILI. Downstaging has been shown to be poorly sensitive and specific to detect cervical neoplasia and is no longer considered as a suitable screening test for cervical cancer. VIA, VIAM and VILI are currently being investigated in multicentre cross-sectional studies (without verification bias, in which cytology and HPV testing are also simultaneously evaluated, and the results of these investigations will be available in 2003. These studies will provide valuable information on the average, comparative test performances in detecting high-grade cervical cancer precursors and cancer. Results from pooled analysis of data from two completed studies indicated an approximate sensitivity of 93.4% and specificity of 85.1% for VIA to detect CIN 2 or worse lesions; the corresponding figures for cytology were 72.1% and 91.6%. The efficacy of VIA in reducing incidence of and mortality from cervical cancer and its cost-effectiveness is currently being investigated

  5. Evaluation of 'see-see and treat' strategy and role of HIV on cervical cancer prevention in Uganda

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    Sandin Sven

    2010-05-01

    Full Text Available Abstract Background There is scant information on whether Human Immunodeficiency Virus (HIV seropositivity has an influence on the outcome of treatment of precancerous cervical lesions using cryotherapy. We studied the prevalence of cervical abnormalities detectable by visual inspection and cervical lesions diagnosed by colposcopy according to HIV serostatus and described the outcomes of cryotherapy treatment. Methods Trained nurses examined women not previously screened for cervical cancer using visual inspection with acetic acid (VIA and Lugol's iodine (VILI in two family planning/post natal clinics in Kampala, Uganda, from February 2007 to August 2008. Women with abnormal visual inspection findings were referred for colposcopic evaluation and HIV testing. Women with precancerous cervical lesions detected at colposcopy were treated mainly by cryotherapy, and were evaluated for treatment outcome after 3 months by a second colposcopy. Results Of the 5 105 women screened, 834 presented a positive screening test and were referred for colposcopy. Of these 625 (75% returned for the colposcopic evaluation and were tested for HIV. For the 608 (97.5% women in the age range 20-60 years, colposcopy revealed 169 women with cervical lesions: 128 had inflammation, 19 had low grade squamous intraepithelial lesion (LGSIL, 13 had high grade squamous intraepithelial lesion (HGSIL, 9 had invasive cervical cancer and 2 had inconclusive findings. Detection rates per 1 000 women screened were higher among the older women (41-60 years compared to women aged 20-40 years. They were accordingly 55% and 20% for inflammation, 10% and 2% for LGSIL, 5% and 2% for HGSIL, 6% and 1% for invasive cervical cancer. Of the 608 women, 103 (16% were HIV positive. HIV positivity was associated with higher likelihood of inflammation (RR = 1.7; 95% CI: 1.2-2.4. Conclusions Detection rates were higher among older women 41-60 years. Visual inspection of the cervix uteri with acetic acid

  6. Trials and projects on cervical cancer and human papillomavirus prevention in sub-Saharan Africa.

    Science.gov (United States)

    Adefuye, Peter O; Broutet, Nathalie J; de Sanjosé, Silvia; Denny, Lynette A

    2013-12-29

    Cervical cancer is the leading cause of cancer morbidity and mortality in women in sub-Saharan Africa (SSA), accounting for about 50,000 deaths annually. Until recently, cytology was the gold standard for screening and prevention of cervical cancer. This method of screening has not been successful in SSA due to a lack of human, financial and material resources and poor health care infrastructure. It is estimated that less than 5% of at risk women have ever being screened. In the past two decades alternative approaches to cytology for cervical cancer screening have been evaluated in low- and medium-income countries. Visual inspection with acetic acid (VIA) and/or Lugol's iodine (VILI) have been shown to have adequate sensitivity, although low specificity, in a number of cross-sectional research and demonstration projects. Visual inspection methods require minimal resources, are technologically accessible, and are feasible for screening for precancerous lesions. Linking screening with VIA/VILI to treatment with cryotherapy may enable screening and treatment to take place in one visit, but this is likely to result in large numbers of women being subjected to unnecessary treatment. A number of studies have shown that cryotherapy is not associated with significant side effects or complications and is well tolerated. Creating the infrastructure for screening of older women is considered desirable, despite the limitations of visual inspection methods as screening tests. Understanding the role of human papillomavirus (HPV) infection in the etiology of cervical cancer and the discovery of HPV rapid test kits, as well as the development of vaccines against the HPV oncogenic types, have created new opportunities for prevention of cervical cancer. Trials and projects have established (and are still ongoing) the feasibility of using these molecular tests for screening. The ultimate in prevention method is primary prevention, offered by the advent of prophylactic vaccines

  7. Baryons and baryonic matter in four-fermion interaction models

    International Nuclear Information System (INIS)

    Urlichs, K.

    2007-01-01

    In this work we discuss baryons and baryonic matter in simple four-fermion interaction theories, the Gross-Neveu model and the Nambu-Jona-Lasinio model in 1+1 and 2+1 space-time dimensions. These models are designed as toy models for dynamical symmetry breaking in strong interaction physics. Pointlike interactions (''four-fermion'' interactions) between quarks replace the full gluon mediated interaction of quantum chromodynamics. We consider the limit of a large number of fermion flavors, where a mean field approach becomes exact. This method is formulated in the language of relativistic many particle theory and is equivalent to the Hartree-Fock approximation. In 1+1 dimensions, we generalize known results on the ground state to the case where chiral symmetry is broken explicitly by a bare mass term. For the Gross-Neveu model, we derive an exact self-consistent solution for the finite density ground state, consisting of a one-dimensional array of equally spaced potential wells, a baryon crystal. For the Nambu- Jona-Lasinio model we apply the derivative expansion technique to calculate the total energy in powers of derivatives of the mean field. In a picture akin to the Skyrme model of nuclear physics, the baryon emerges as a topological soliton. The solution for both the single baryon and dense baryonic matter is given in a systematic expansion in powers of the pion mass. The solution of the Hartree-Fock problem is more complicated in 2+1 dimensions. In the massless Gross-Neveu model we derive an exact self-consistent solution by extending the baryon crystal of the 1+1 dimensional model, maintaining translational invariance in one spatial direction. This one-dimensional configuration is energetically degenerate to the translationally invariant solution, a hint in favor of a possible translational symmetry breakdown by more general geometrical structures. In the Nambu-Jona-Lasinio model, topological soliton configurations induce a finite baryon number. In contrast

  8. Baryons and baryonic matter in four-fermion interaction models

    Energy Technology Data Exchange (ETDEWEB)

    Urlichs, K.

    2007-02-23

    In this work we discuss baryons and baryonic matter in simple four-fermion interaction theories, the Gross-Neveu model and the Nambu-Jona-Lasinio model in 1+1 and 2+1 space-time dimensions. These models are designed as toy models for dynamical symmetry breaking in strong interaction physics. Pointlike interactions (''four-fermion'' interactions) between quarks replace the full gluon mediated interaction of quantum chromodynamics. We consider the limit of a large number of fermion flavors, where a mean field approach becomes exact. This method is formulated in the language of relativistic many particle theory and is equivalent to the Hartree-Fock approximation. In 1+1 dimensions, we generalize known results on the ground state to the case where chiral symmetry is broken explicitly by a bare mass term. For the Gross-Neveu model, we derive an exact self-consistent solution for the finite density ground state, consisting of a one-dimensional array of equally spaced potential wells, a baryon crystal. For the Nambu- Jona-Lasinio model we apply the derivative expansion technique to calculate the total energy in powers of derivatives of the mean field. In a picture akin to the Skyrme model of nuclear physics, the baryon emerges as a topological soliton. The solution for both the single baryon and dense baryonic matter is given in a systematic expansion in powers of the pion mass. The solution of the Hartree-Fock problem is more complicated in 2+1 dimensions. In the massless Gross-Neveu model we derive an exact self-consistent solution by extending the baryon crystal of the 1+1 dimensional model, maintaining translational invariance in one spatial direction. This one-dimensional configuration is energetically degenerate to the translationally invariant solution, a hint in favor of a possible translational symmetry breakdown by more general geometrical structures. In the Nambu-Jona-Lasinio model, topological soliton configurations induce a finite baryon

  9. A heurística do medo, muito além da precaução

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    Ricardo Abramovay

    2016-04-01

    Full Text Available Por mais que o avanço da ciência e da tecnologia esteja na raiz de vitórias decisivas na luta por melhores condições sociais, é impossível não reconhecer a ameaça crescente que o conhecimento e suas aplicações práticas representam não só para as sociedades humanas, mas para a vida em seu conjunto. A capacidade humana de intervir sobre a natureza é hoje muito maior que a possibilidade de prever com um mínimo de segurança os resultados dessa intervenção. Para Hans Jonas esse contraste só pode ser abordado com base numa exigência ética que ele sintetiza no Princípio Responsabilidade, e que se apoia na heurística do medo. Baseado numa abordagem crítica do dualismo que marca a cultura ocidental e separa matéria e espírito, corpo e mente, natureza e sociedade, Hans Jonas rejeita a ideia de que uma organização social voltada explicitamente à satisfação das necessidades humanas (e não ao lucro suprima a exigência de uma reflexão específica sobre as ameaças vindas da expansão autônoma da ciência e da tecnologia. Este trabalho, além de expor as bases do dualismo estudado por Jonas, procura mostrar que suas preocupações não são contempladas pela eventual adoção do princípio da precaução e mostra, ao final, duas áreas (biologia e geoengenharia em que a aplicação de sua filosofia da tecnologia pode ser especialmente relevante.

  10. Jono Bretkūno Biblijos germanizmai

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    Nijolė Čepienė

    2011-12-01

    Full Text Available GERMANISMEN IN DER BIBEL VON JONAS BRETKŪNASZusammenfassungDie Bibel des Jonas Bretkūnas (1579-1590 (weiter BB ist die wertvollste handschriftliche Über­setzung des XVI. Jhs. aus dem Deutschen (Lukas Evangelium ist aus dem Lateinischen übersetzt. Sie enthält viele sprachliche Schätze, die die Lage der Sprache und die kulturelle Umgebung des Klein Litauens im XVI. Jh. widerspiegeln.Beim Vergleich der BB mit den anderen altlitauischen Schriften des XVI. Jhs. stellte sich heraus, daß BB am meisten Germanismen, etwa 300, enthält. Es sind meistens deutsche Lehnwörter aus dem Niederdeutschen und Hochdeutschen. Die Mehrheit der Germanismen bilden kulturelle Lehnwörter, die wegen der Sprachkontakte entstanden sind. Manche Lehnwörter gelangten ins Litauische wahr­scheinlich auf dem literarischen Wege, d.h. bei der Übersetzung der Religionsschriften (psalteras „Psal­ter“, mirrhas „Myrrhe“, izopas „Isop“. Einige Lehnwörter könnten ohne Vermittlung der slawischen Sprachen ins Litauische gelangen, z.B.: gruntas (Grund, pancierius (Panzer, šnuras (Schnur.Die Eigentümlichkeit der Übersetzung des Bretkūnas ist das Zusammenhäufen der lexikalischen Va­rianten, Synonyme; einige Wörter sind von den Korrektoren zugeschrieben. Die Germanismen kommen im Haupttext und in späteren Korrekturen vor. Viele Varianten haben die Lehnwörter šturmas „Sturm“, kunstas „Kunst“, spikerė „Speicher“, spangas „Spange“ u.a. Die Beispiele zeigen, daß Bretkūnas wollte nicht die Lehnwörter aus dem Text wegwerfen. Er gab Varianten, manche in Parenthesen, als ob der Leser selbst die passenden Wörter wählte. Viele Varianten entstanden wegen der Vieldeutigkeit der Wörter, ihrer semantischen Nuancen. Sie zeigen, daß Bretkūnas bei der Übersetzung der Bibel oft zweifelte, welches Wort besser passt. Er schätzte die Varianten ein, einige schreibend in Parenthesen, andere unterstreichend oder ausstreichend, trotzdem blieb oft keine

  11. Views on Biotic Nature and the Idea of Sustainable Development

    Science.gov (United States)

    Łepko, Zbigniew

    2017-12-01

    The search for balance between humankind's civilisational aspirations and the durable protection of nature is conditioned by contemporaneous views of biotic nature. Of particular importance in this regard are physiocentric and physiological views that may be set against one another. The first of these was presented by Hans Jonas, the second by Lothar Schäfer. This paper does not confine itself to setting one view against the other, but rather sets minimum conditions for cooperation between their promoters in the interests of balance between the aspirations of the present generation and those of future generations. Both views of nature are in their own way conducive to a break with the illusion present in some areas of the modern natural sciences - that nature is a boundless area of are inexhaustible resources.

  12. Vector mesons on the light front

    International Nuclear Information System (INIS)

    Naito, K.; Maedan, S.; Itakura, K.

    2004-01-01

    We apply the light-front quantization to the Nambu-Jona-Lasinio model with the vector interaction, and compute vector meson's mass and light-cone wavefunction in the large N limit. Following the same procedure as in the previous analyses for scalar and pseudo-scalar mesons, we derive the bound-state equations of a qq-bar system in the vector channel. We include the lowest order effects of the vector interaction. The resulting transverse and longitudinal components of the bound-state equation look different from each other. But eventually after imposing an appropriate cutoff, one finds these two are identical, giving the same mass and the same (spin-independent) light-cone wavefunction. Mass of the vector meson decreases as one increases the strength of the vector interaction

  13. Neutron-proton mass difference in a baryonic medium and the Nolen-Schiffer anomaly

    International Nuclear Information System (INIS)

    Fiolhais, M.; Christov, C.; Neuber, T.; Bergmann, M.; Goeke, K.

    1991-01-01

    The neutron-proton mass difference ΔM np = M n - M p in a baryonic medium is evaluated in the framework of the Nambu-Jona-Lasinio model. It is demonstrated that ΔM np (ρ) increases with increasing medium density, ρ, a trend being opposite to the one required to explain the Nolen-Schiffer anomaly as suggested by Henley and Krein. In the same conceptual framework the quantity M n (ρ n ) - M p (ρ p ) is evaluated which takes into account that the valence orbits of the proton and the neutron are different. The calculations show that this quantity goes into the right direction, but the effect is an order of magnitude larger than needed to explain the Nolen-Schiffer anomaly. (orig.)

  14. Verantwortung angesichts humanbiologischer Herausforderungen

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    Antje Kapust

    2016-09-01

    Full Text Available With the advancement of the new biotechnologies the problem of responsibility is becoming particularly acute. Instead of giving an own definition of responsibility, the author proposes to take it as a heuristic concept based on some Husserlian ideas developed in the Krisis. This ideas, which have some similarity with Jonas' principle of responsibility, are: first, responsibility as care for the vulnerable, second, responsibility in the context of a horizon of possibilities, and, third, responsibility for the own prerequisites as human being. By applying the hermeneutics of suspicion to some current issues, the author argues that the biotechnological revolution comes along with a shift of the cultures of recognition onto cultures of consumption. On the base of different arguments used in the biotechnological debates (arguments of status, of action relevance, of moral and right, three types of responsibility are revealed: the aporetic, the consecutive, and the quasi-hermeneutical responsibility, which enables a final controversy about their deficiency.

  15. e +e- modes and U(1) spontaneous chiral symmetry breaking

    International Nuclear Information System (INIS)

    Steininger, K.

    1992-01-01

    In this paper, motivated by evidence for a chiral phase transition in strong coupling lattice QED, the authors calculate the two-particle spectrum of the broken QED phase. This is done in the framework of a Nambu and Jona-Lasinio model with U(1) symmetry including chiral symmetry and symmetry breaking properties of QED. The second order chiral phase transition behavior in our model and in lattice QED are in excellent agreement. The authors then present a detailed analysis of the spectra of the e + e - modes in the broken phase. The authors examine whether these modes have any possible relationship to the narrow e + e - resonances found in soft heavy ion collisions at GSL. The authors' answer is negative

  16. The form and function of space in the Jonah narrative in Prudentius Cathemerinon 7.81-175

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    J. H. Barkhuizen

    1988-05-01

    Full Text Available In hierdie artikel word ’n analise gemaak van die struktuur en funksie van narratiewe ruimte in die Jona-verhaal sees vertel deur Prudentius (Cathemerinon 1. Hierdie verhaal is gekies omdat dit by uitstek ruimte-georiënteerd is. Die analise is gebaseer op ’n verwerking van die teorie van G. Zoran, wat narratiewe ruimte op tekstuele en plot-vlak ondersoek, Ruimte op tekstuele vlak verwys na die topografiese aard van ruimte, dit wil sê van objekte en plekke, asook die beginsel van die teks-perspektief van sodanige objekte en plekke. Die topografiese aard van ruimte behels weer aspekte soos horisontale en vertikale opposisies, kwaliteitstrukture en ontologiese beginsels. Ruimte op die plot-vlak verwys na sinchroniese en diachroniese relasies. Eersgenoemde het te doen met die beginsel van beweging en rus, terwyl laasgenoemde te doen het met bepaalde rigtinge en intensies op die plot-vlak.

  17. Dual realizations of dynamical symmetry breaking

    International Nuclear Information System (INIS)

    Dudas, Emilian; Papineau, Chloe

    2006-01-01

    We show the infrared equivalence between a recently proposed model containing a six dimensional scalar field with a four-dimensional localized Higgs type potential and the four-dimensional Nambu-Jona-Lasinio (NJL) model. In the dual NJL description, the fermions are localized at the origin of a large two-dimensional compact space. Due to a classical running effect above the compactification scale, the four-fermion coupling of the NJL model increases from the cutoff scale down to the compactification scale, providing the large Fermi coupling needed for the dynamical symmetry breaking. We also present a string theory embedding of our field-theory construction. On more general grounds, our results suggest that 4d models with dynamical symmetry breaking can be given a higher dimensional description in terms of field theories with nontrivial boundary conditions in the internal space

  18. A new mass relation among the hadron vector resonances

    CERN Document Server

    Chizhov, M.V.

    2001-01-01

    We show that the hadron vector resonances are described by fields transforming according to different inequivalent representations of the Lorentz group: (1/2,1/2) and (1,0)+(0,1). The vector representation (1/2,1/2) is well studied and corresponds to the gauge fields. On the other hand, the chiral representations (1,0) and (0,1) are described by the second rank antisymmetric tensor fields, for which interaction theory has not yet been constructed. In the framework of the phenomenological Nambu - Jona-Lasinio approach we have introduced and used all these fields for a description of the vector resonances. A new mass relation between low-lying hadron vector and axial-vector resonances is obtained. This relation is in agreement with the present experimental data.

  19. Non-perturbative effective interactions in the standard model

    CERN Document Server

    Arbuzov, Boris A

    2014-01-01

    This monograph is devoted to the nonperturbative dynamics in the Standard Model (SM), the basic theory of all, but gravity, fundamental interactions in nature. The Standard Model is devided into two parts: the Quantum chromodynamics (QCD) and the Electro-weak theory (EWT) are well-defined renormalizable theories in which the perturbation theory is valid. However, for the adequate description of the real physics nonperturbative effects are inevitable. This book describes how these nonperturbative effects may be obtained in the framework of spontaneous generation of effective interactions. The well-known example of such effective interaction is provided by the famous Nambu--Jona-Lasinio effective interaction. Also a spontaneous generation of this interaction in the framework of QCD is described and applied to the method for other effective interactions in QCD and EWT. The method is based on N.N. Bogoliubov conception of compensation equations. As a result we then describe the principle feathures of the Standard...

  20. Salk's HIV immunogen: an immune-based therapy in human trials since 1988.

    Science.gov (United States)

    Jonas Salk, the developer of the first polio vaccine, has created a therapeutic vaccine for HIV which helps the immune system fight disease progression. Salk uses inactivated HIV-1 virus combined with Incomplete Freund's Adjuvant (IFA) in the vaccine preparation. The resulting HIV-1 immunogen was first studied in 1987, and since then, 235 seropositive individuals have received inoculations without serious adverse effects. Data from the first 25 subjects indicate that immunization with the HIV-1 immunogen results in improvement of cell-mediated response against the virus, a slower increase in the amount of virus present, and a reduced rate of clinical progression. Subsequent studies also show that higher doses of immunogen may produce stronger cell-mediated responses and high HIV-DTH (delayed-type hypersensitivity responsiveness immunogen) is associated with better outcome. Additional trials of HIV-1 immunogen are awaiting Food and Drug Administration approval.

  1. Current status of poliovirus infections.

    Science.gov (United States)

    Melnick, J L

    1996-07-01

    Two scientists who played leading roles in the conquest of poliomyelitis died recently. In 1954, Jonas Salk provided the first licensed polio vaccine, the formalin (and heat)-inactivated virus. Albert Sabin gave us the attenuated live virus vaccine, which was licensed in 1962. This paper takes the reader through the history of the disease, including its pathogenesis, epidemiology, vaccines, and future directions. The emphasis is on vaccines, for it seems that with proper vaccination the number of new cases is falling dramatically. It is hoped that by the year 2000, we will accomplish the goal of the World Health Organization of "a world without polio." Then, because there is no animal reservoir, we can seriously discuss when and how to eliminate the need for vaccination and ultimately destroy our stocks of poliovirus.

  2. Remune trial will stop; new trials planned.

    Science.gov (United States)

    James, J S

    1999-05-21

    A clinical trial using remune, the anti-HIV vaccine developed by the late Dr. Jonas Salk, has been ended. The study is a clinical-endpoint trial which looks for statistically significant differences in AIDS sickness or death between patients who add remune to their treatment regimens versus those who use a placebo. Agouron Pharmaceuticals and the Immune Response Corporation who were conducting the trial announced their decision to stop it after an analysis by the Data Safety Monitoring Board. No differences in clinical endpoints were found and it was projected that continuing the trial would likely not find any. The companies are now planning two new Phase III trials using viral load testing rather than clinical endpoints as study criteria.

  3. G. Stanley Hall and The Journal of Genetic Psychology: A Note.

    Science.gov (United States)

    Hogan, John D

    2016-01-01

    The Journal of Genetic Psychology (originally called The Pedagogical Seminary) has a complicated history. Known primarily as a journal of development psychology, it was originally intended to be a journal of higher education. In addition, G. Stanley Hall created it, at least in part, to curry favor with Jonas Clark, the benefactor of Clark University. The journal had a cumbersome start, with irregular issues for most of its first decade. Hall was a hands-on editor, often contributing articles and reviews as well as the texts of many of his speeches. A substantial number of additional articles were written by Clark University faculty and fellows where Hall was president. After Hall.s death, the editor became Carl Murchison who eventually left Clark University with the journal and continued to publish it privately until his death. Through the years, the journal has been the source for many classic articles in developmental psychology.

  4. Parity doublers in chiral potential quark models

    International Nuclear Information System (INIS)

    Kalashnikova, Yu. S.; Nefediev, A. V.; Ribeiro, J. E. F. T.

    2007-01-01

    The effect of spontaneous breaking of chiral symmetry over the spectrum of highly excited hadrons is addressed in the framework of a microscopic chiral potential quark model (Generalised Nambu-Jona-Lasinio model) with a vectorial instantaneous quark kernel of a generic form. A heavy-light quark-antiquark bound system is considered, as an example, and the Lorentz nature of the effective light-quark potential is identified to be a pure Lorentz-scalar, for low-lying states in the spectrum, and to become a pure spatial Lorentz vector, for highly excited states. Consequently, the splitting between the partners in chiral doublets is demonstrated to decrease fast in the upper part of the spectrum so that neighboring states of an opposite parity become almost degenerate. A detailed microscopic picture of such a 'chiral symmetry restoration' in the spectrum of highly excited hadrons is drawn and the corresponding scale of restoration is estimated

  5. Quantum and classical gauge symmetries

    International Nuclear Information System (INIS)

    Fujikawa, Kazuo; Terashima, Hiroaki

    2001-01-01

    The use of the mass term of the gauge field as a gauge fixing term, which was discussed by Zwanziger, Parrinello and Jona-Lasinio in a large mass limit, is related to the non-linear gauge by Dirac and Nambu. We have recently shown that this use of the mass term as a gauge fixing term is in fact identical to the conventional local Faddeev-Popov formula without taking a large mass limit, if one takes into account the variation of the gauge field along the entire gauge orbit. This suggests that the classical massive vector theory, for example, could be re-interpreted as a gauge invariant theory with a gauge fixing term added in suitably quantized theory. As for massive gauge particles, the Higgs mechanics, where the mass term is gauge invariant, has a more intrinsic meaning. We comment on several implications of this observation. (author)

  6. Analysis of Fusarium avenaceum Metabolites Produced during Wet Apple Core Rot

    DEFF Research Database (Denmark)

    Sørensen, Jens Laurids; Phipps, Richard Kerry; Nielsen, Kristian Fog

    2009-01-01

    Wet apple core rot (wACR) is a well-known disease of susceptible apple cultivars such as Gloster, Jona Gold, and Fuji. Investigations in apple orchards in Slovenia identified Fusarium avenaceum, a known producer of several mycotoxins, as the predominant causal agent of this disease. A LC...... and naturally infected apples. Levels of moniliformin, antibiotic Y, aurofusarin, and enniatins A, A1, B, and B1 were quantitatively examined in artificially inoculated and naturally infected apples, whereas the remaining metabolites were qualitatively detected. Metabolite production was examined...... in artificially inoculated apples after 3, 7, 14, and 21 days of incubation. Most metabolites were detected after 3 or 7 days and reached significantly high levels within 14 or 21 days. The highest levels of moniliformin, antibiotic Y, aurofusarin, and the combined sum of enniatins A, A1, B, and B1 were 7.3, 5...

  7. Elite athletes experiences with risk related to cardiac screening

    DEFF Research Database (Denmark)

    Christensen, Jonas Schmidt; Thing, Lone Friis

    Society of Cardiology as well as major sports federations such as the International Olympic Committee, however, these recommendations seem to be based on an inadequate empirical foundation, just as the costs of performing cardiac screening on a larger scale seem out of proportion. Additionally, the field...... perspective on risk (Foucault 1988). For most elite athletes participation in cardiac screening is done out of a wish to obtain an acquittal from risks. Symptomatic of the risk society cardiac screening can from an athlete perspective at the same time be seen as an attempt to gain control over......Elite Athletes experiences with risks related to Cardiac Screening Jonas Schmidt Christensen1, Lone Friis Thing1 1University of Copenhagen - Department of Nutrition, Exercise and Sports (NEXS), Cardiac screening of elite athletes are recommended by both the American Heart Association & the European...

  8. Unification of all elementary-particle forces including gravity

    International Nuclear Information System (INIS)

    Terazawa, Hidezumi; Chikashige, Yuichi; Matsuki, Takayuki; Akama, Keiichi.

    1978-07-01

    A unified model of the Nambu-Jona-Lasinio type for all elementary-particle forces including gravity is reviewed in some detail. Starting with a nonlinear fermion Lagrangian of the Heisenberg type and imposing the massless conditions of Bjorken on vector auxiliary fields, on effective Lagrangian is constructed, which combines the unified SU (2) x U (1) gauge theory of Weinberg and Salam for the weak and electromagnetic interactions of leptons and quarks and the Yang-Mills gauge theory of color SU (3) for the strong interaction of quarks. The photon, the weak vector bosons, and the physical Higgs scalar appear as collective excitations of lepton-antilepton or quark-antiquark pairs while the color-octet gluons appear as those of quark-antiquark pairs. The most important results of this unified model are presented. The Weinberg angle and the gluon coupling constant are determined, and the masses of the weak vector bosons are predicted. (Yoshimori, M.)

  9. Organic photovoltaics

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    Within the International Conference and Exhibition at 16th September,2010 at the Maritim Hotel (Wuerzburg, Federal Republic of Germany) the following lectures were held: (1) History of Organic Photovoltaics (Niyazi Serdar Sariciftci); (2) PV Activities at the ZAE Bayern (Vladimir Dyakonov); (3) Progress in Solid State DSC (Peter Erk); (4) Polymer Semiconductors for OPV (Mats Andersson); (5) Fullerene Derivative N-Types in Organic Solar Cells (David Kronholm); (6) Modelling Charge-Transport in Organic Photovoltaic Materials (Jenny Nelson); (7) Multi Junction Modules R and D Status and Outlook (Paul Blom); (8) Imaging Technologies for Organic Solar Cells (Jonas Bachmann); (9) Production of Multi-junction Organic Photovoltaic Cells and Modules (Martin Pfeiffer); (10) Upscaling of Polymer Solar Cell Fabrication Using Full Roll-to-roll Processing (Frederik Christian Krebs); (11) Industrial Aspects and Large Scale OPV Production (Jens Hauch).

  10. Making it work

    DEFF Research Database (Denmark)

    Winther, Jonas

    Within the field of health research, the randomised controlled trial (RCT) is often highlighted as the best method for producing statistically valid evidence about the effects of health interventions. To produce evidence that is also socially relevant, health researchers increasingly perform trials...... outside the laboratory in people’s everyday lives. This creates a situation, in which scientific ideals of methodological rigour must be made to work with trial participants and their ongoing everyday lives. Jonas Winther’s dissertation, Making it Work, explores how this ambition is pursued in practice....... The dissertation builds on Winther’s engagement as an ethnologist in an interdisciplinary research project in Denmark, which was structured around an intervention trial that tested the health effects of exercise in everyday life. Through ethnographic fieldwork among the participants and the researchers...

  11. Chiral symmetry restoration and quasi-elastic electron-nucleus scattering

    International Nuclear Information System (INIS)

    Henley, E.M.; Krein, G.

    1989-01-01

    Chiral symmetry is known to be an important concept in hadronic interactions. It holds in QCD, but is known to be broken at low energies. It is therefore useful to study chiral symmetry and its breaking together with its consequences in nuclear physics. It is the latter phenomena we consider here. It is difficult to study nonperturbative QCD at low energies and models are needed. The Nambu-Jona-Lasinio (NJL) model fits this category; it incorporates chiral symmetry and its breaking, and allows one to study its effects in nucleons and nuclei. In particular, the constituent quark mass varies with density (ρ) and temperature (T). At high ρ and T chiral symmetry is restored. It is the ρ dependence which yields important effects in electron scattering due to partial restoration of chiral symmetry in nuclei. We begin with the NJL model with a small chiral symmetry breaking

  12. The effect of dynamical quark mass on the calculation of a strange quark star's structure

    Institute of Scientific and Technical Information of China (English)

    Gholam Hossein Bordbar; Babak Ziaei

    2012-01-01

    We discuss the dynamical behavior of strange quark matter components,in particular the effects of density dependent quark mass on the equation of state of strange quark matter.The dynamical masses of quarks are computed within the Nambu-Jona-Lasinio model,then we perform strange quark matter calculations employing the MIT bag model with these dynamical masses.For the sake of comparing dynamical mass interaction with QCD quark-quark interaction,we consider the one-gluon-exchange term as the effective interaction between quarks for the MIT bag model.Our dynamical approach illustrates an improvement in the obtained equation of state values.We also investigate the structure of the strange quark star using TolmanOppenheimer-Volkoff equations for all applied models.Our results show that dynamical mass interaction leads to lower values for gravitational mass.

  13. Las políticas públicas en la sociedad globalizada

    Directory of Open Access Journals (Sweden)

    Martha Isabel Gomez Lee

    2008-11-01

    Full Text Available En estos días los retos económicos, ambientales y políticos, tales como la falta de una balanceada integración del mercado global y la incertidumbre de la sustentabilidad de la vida en el planeta, hacen imprescindible replantear el rol del Estado. El análisis de las políticas públicas es la disciplina que permite adoptar conocimiento sobre la sociedad civil global a partir del análisis de sus actuaciones concretas. El Estado debe reconocerse a sí mismo como actor posicional en la sociedad civil global, y redireccionar la globalización a una cara más humana y extrahumana. En términos generales el presente artículo se refiere a esta temática basándose en los trabajos de Joseph Stiglitz, Hans Jonas y otros autores.

  14. The convergence radius of the chiral expansion in the Dyson-Schwinger approach

    International Nuclear Information System (INIS)

    Meissner, T.

    1994-01-01

    We determine the convergence radius m conv or the expansion in the current quark mass using the Dyson-Schwinger (DS) equation of QCD in the rainbow approximation. Within a Gaussian form for the gluon propagator D μ ν(p) ∼ δμνχ 2 e - Δ /p 2 we find that m conv increases with decreasing width Δ and increasing strength χ 2 . For those values of χ 2 and Δ, which provide the best known description of low energy hadronic phenomena, m conv lies around 2Λ QCD , which is big enough, that the chiral expansion in the strange sector converges. Our analysis also explains the rather low value of m conv ∼ 50...80 MeV in the Nambu-Jona-Lasinio model, which as itself can be regarded as a special case of the rainbow DS models, where the gluon propagator is a constant in momentum space

  15. American alliances and nuclear non-proliferation. The end of nuclear weapon activities of US allies

    International Nuclear Information System (INIS)

    Schneider, Jonas

    2016-01-01

    Jonas Schneider tackles a question that is of great interest both to scholars of nuclear proliferation and to practitioners of nonproliferation diplomacy: Why do some political leaders of U.S. allies agree to abandon their nation's nuclear weapons activities, while others - who are often members of the same allied government and sometimes even of the same political party - steadfastly reject such a course reversal? Our existing stock of theories does not fare well in accounting for this important variation in leaders' attitudes. To solve this puzzle, Schneider develops an innovative theory that draws on the individual status conceptions of allied political leaders. Subsequently, the author undertakes to test his theory using four thoroughly researched case studies, and he derives important lessons for international nonproliferation diplomacy toward the Middle East and Northeast Asia.

  16. Cantacronache 1958-1962. Politica e protesta in musica

    Directory of Open Access Journals (Sweden)

    Chiara Ferrari

    2013-09-01

    Full Text Available At the end of the 50s the italian band from Turin, named Cantacronache, created social and political songs, so contributing to the birth of a new musical genre in Italy. The founders Michele Luciano Straniero, Sergio Liberovici, Emilio Jona, Fausto Amodei, Margherita Galante Garrone, were joined from the collaboration of writers and poets like Mario Pogliotti, Franco Fortini, Italo Calvino, Umberto Eco, Gianni Rodari. The name of the group reveals its vocation: telling reality, writing songs about news facts in order to give them back to collective memory. Among the covered themes: italian news, Resistence, the research of social and political songs of the past or the recovery of the popular music heritage.

  17. NJL-jet model for quark fragmentation functions

    International Nuclear Information System (INIS)

    Ito, T.; Bentz, W.; Cloeet, I. C.; Thomas, A. W.; Yazaki, K.

    2009-01-01

    A description of fragmentation functions which satisfy the momentum and isospin sum rules is presented in an effective quark theory. Concentrating on the pion fragmentation function, we first explain why the elementary (lowest order) fragmentation process q→qπ is completely inadequate to describe the empirical data, although the crossed process π→qq describes the quark distribution functions in the pion reasonably well. Taking into account cascadelike processes in a generalized jet-model approach, we then show that the momentum and isospin sum rules can be satisfied naturally, without the introduction of ad hoc parameters. We present results for the Nambu-Jona-Lasinio (NJL) model in the invariant mass regularization scheme and compare them with the empirical parametrizations. We argue that the NJL-jet model, developed herein, provides a useful framework with which to calculate the fragmentation functions in an effective chiral quark theory.

  18. Kaon fragmentation function from NJL-jet model

    International Nuclear Information System (INIS)

    Matevosyan, Hrayr H.; Thomas, Anthony W.; Bentz, Wolfgang

    2010-01-01

    The NJL-jet model provides a sound framework for calculating the fragmentation functions in an effective chiral quark theory, where the momentum and isospin sum rules are satisfied without the introduction of ad hoc parameters [1]. Earlier studies of the pion fragmentation functions using the Nambu-Jona-Lasinio (NJL) model within this framework showed good qualitative agreement with the empirical parameterizations. Here we extend the NJL-jet model by including the strange quark. The corrections to the pion fragmentation function and corresponding kaon fragmentation functions are calculated using the elementary quark to quark-meson fragmentation functions from NJL. The results for the kaon fragmentation function exhibit a qualitative agreement with the empirical parameterizations, while the unfavored strange quark fragmentation to pions is shown to be of the same order of magnitude as the unfavored light quark's. The results of these studies are expected to provide important guidance for the analysis of a large variety of semi-inclusive data.

  19. Quark distributions in nuclear matter and the EMC effect

    Energy Technology Data Exchange (ETDEWEB)

    Mineo, H.; Bentz, W. E-mail: bentz@keyaki.cc.u-tokai.ac.jp; Ishii, N.; Thomas, A.W.; Yazaki, K

    2004-05-03

    Quark light cone momentum distributions in nuclear matter and the structure function of a bound nucleon are investigated in the framework of the Nambu-Jona-Lasinio model. This framework describes the nucleon as a relativistic quark-diquark state, and the nuclear matter equation of state by using the mean field approximation. The scalar and vector mean fields in the nuclear medium couple to the quarks in the nucleon and their effect on the spin independent nuclear structure function is investigated in detail. Special emphasis is placed on the important effect of the vector mean field and on a formulation which guarantees the validity of the number and momentum sum rules from the outset.

  20. EMC and polarized EMC effects in nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Cloet, I.C. [Special Research Centre for the Subatomic Structure of Matter and Department of Physics and Mathematical Physics, University of Adelaide, SA 5005 (Australia); Jefferson Lab, 12000 Jefferson Avenue, Newport News, VA 23606 (United States)]. E-mail: icloet@jlab.org; Bentz, W. [Department of Physics, School of Science, Tokai University, Hiratsuka-shi, Kanagawa 259-1292 (Japan)]. E-mail: bentz@keyaki.cc.u-tokai.ac.jp; Thomas, A.W. [Jefferson Lab, 12000 Jefferson Avenue, Newport News, VA 23606 (United States)]. E-mail: awthomas@jlab.org

    2006-11-09

    We determine nuclear structure functions and quark distributions for {sup 7}Li, {sup 11}B, {sup 15}N and {sup 27}Al. For the nucleon bound state we solve the covariant quark-diquark equations in a confining Nambu-Jona-Lasinio model, which yields excellent results for the free nucleon structure functions. The nucleus is described using a relativistic shell model, including mean scalar and vector fields that couple to the quarks in the nucleon. The nuclear structure functions are then obtained as a convolution of the structure function of the bound nucleon with the light-cone nucleon distributions. We find that we are readily able to reproduce the EMC effect in finite nuclei and confirm earlier nuclear matter studies that found a large polarized EMC effect.

  1. Axial vector diquark correlations in the nucleon: structure functions and static properties

    Energy Technology Data Exchange (ETDEWEB)

    Mineo, H. E-mail: mineo@nt.phys.s.u-tokyo.ac.jp; Bentz, W.; Ishii, N.; Yazaki, K

    2002-06-03

    In order to extract information on the strength of quark-quark correlations in the axial vector (a.v.) diquark channel (J{sup P}=1{sup +},T=1), we analyze the quark light cone momentum distributions in the nucleon, in particular their flavor dependencies, and the static properties of the nucleon. To construct the nucleon as a relativistic 3-quark bound state, we use a simple 'static' approximation to the full Faddeev equation in the Nambu-Jona-Lasinio model, including correlations in the scalar (J{sup P}=0{sup +},T=0) and a.v. diquark channels. It is shown that the a.v. diquark correlations should be rather weak compared to the scalar ones. From our analysis we extract information on the strength of the correlations as well as on the probability of the a.v. diquark channel.

  2. Two-color quark matter: U(1)A restoration, superfluidity, and quarkyonic phase

    International Nuclear Information System (INIS)

    Brauner, Tomas; Fukushima, Kenji; Hidaka, Yoshimasa

    2009-01-01

    We discuss the phase structure of quantum chromodynamics (QCD) with two colors and two flavors of light quarks. This is motivated by the increasing interest in the QCD phase diagram as follows: (1) The QCD critical point search has been under intensive dispute and its location and existence suffer from uncertainty of effective U(1) A symmetry restoration. (2) A new phase called quarkyonic matter is drawing theoretical and experimental attention but it is not clear whether it can coexist with diquark condensation. We point out that two-color QCD is nontrivial enough to contain essential ingredients for (1) and (2) both, and most importantly, is a system without the sign problem in numerical simulations on the lattice. We adopt the two-flavor Nambu-Jona-Lasinio model extended with the two-color Polyakov loop and make quantitative predictions that can be tested by lattice simulations.

  3. Betti numbers of graded modules and cohomology of vector bundles

    Science.gov (United States)

    Eisenbud, David; Schreyer, Frank-Olaf

    2009-07-01

    In the remarkable paper Graded Betti numbers of Cohen-Macaulay modules and the multiplicity conjecture, Mats Boij and Jonas Soederberg conjectured that the Betti table of a Cohen-Macaulay module over a polynomial ring is a positive linear combination of Betti tables of modules with pure resolutions. We prove a strengthened form of their conjectures. Applications include a proof of the Multiplicity Conjecture of Huneke and Srinivasan and a proof of the convexity of a fan naturally associated to the Young lattice. With the same tools we show that the cohomology table of any vector bundle on projective space is a positive rational linear combination of the cohomology tables of what we call supernatural vector bundles. Using this result we give new bounds on the slope of a vector bundle in terms of its cohomology.

  4. Tre lampor och ett ben : produktserie för Gotlands Lampfabrik

    OpenAIRE

    Johansson, Emma

    2010-01-01

    Gotlands Lampfabrik är en nystartad verksamhet (2009) som drivs av Jonas Kling och Jane Odell centralt på Gotland. De producerar stilrena lampskärmar i ett ljust polymermaterial med papp på båda sidorna. Produktionen är liten och görs för hand på plats i den egna fabriken i Väskinde. Sortimentet består av 33 lampskärmar och i nuläget producerar inte Gotlands Lampfabrik sina egna lampben eller upphängningar utan köper in dem från fristående parter vilket medför att sortimentet kan uppfattas so...

  5. Temperature profiles in a steam-liquid sodium jet. Application to wastage

    International Nuclear Information System (INIS)

    Park, K.H.

    1983-12-01

    The first part of this work presents a certain number of recalls concerning wastage, jets, sonic jets, turbulent jets reactive or not. The aim of this thesis is to group the theoretical formulas concerning gaseous jets in liquids, to determine from experiments the temperature distributions inside the reactive jet, and to establish correlations between the theory and the experiments carried out to obtain a model representative of the temperature distribution in steam jets into liquid sodium. The theoretical development is presented (differential and integral approaches), as also the experiments (JONAS) developed to determine the temperature distribution. The field of validity of experiments and approximations is then defined in view of application to wastage [fr

  6. Teater

    Index Scriptorium Estoniae

    2006-01-01

    Vanemuise teatri draamanäitlejad tunnistasid möödunud aasta parimaks lavastuseks augustis Setumaal Obinitsas etendunud "Taarka", mille lavastas Ain Mäeots. Parimaks naispeaosatäitjaks valiti Merle Jääger, parimaks meespeaosatäitjaks Indrek Taalmaa, parimaks naiskõrvalosatäitjaks Karin Tammaru, parimaks meeskõrvalosatäitjaks Tanel Jonas. Eesti Draamateatri 2005. aasta Antsud ehk kolleegipreemiate laureaadid : Ingomar Vihmar (parim lavastaja), Ervin Õunapuu (parim kunstnik), Ülle Kaljuste (parim naisnäitleja), Ain Lutsepp (parim meesnäitleja), Väikesed Antsud pälvisid Elina Reinold ja Taavi Teplenkov, Abi-Antsuks kuulutati teatri kirjandusala juhataja Ene Paaver. Endla 2005. aasta kolleegipreemiad said Lii Tedre (parim naisnäitleja), Tambet Seling (parim meesnäitleja), Tiit Palu (parim lavastaja) ja Silver Vahtre (parim kunstnik)

  7. Greed, grievance, leadership and external interventions in the initiation and intensification of the civil war in Angola

    Directory of Open Access Journals (Sweden)

    Ricardo Real P. Sousa

    2016-05-01

    Full Text Available Understanding the initiation of conflict is fundamental for the success of efforts in conflict prevention. The validity of the mechanisms of the “Greed and Grievance” model, alongside leadership and external interventions are tested in four periods of initiation and intensification of the conflict in Angola. All mechanisms are present but their relative relevance varies throughout the conflict. Among the mechanisms identified in each period the most relevant in the Cold War period are the international and regional interventions in 1961 and 1975 and in the post-Cold War period, the “greed” factors in 1992 (oil and diamonds, poverty and war capital and the UNITA leadership of Jonas Savimbi in 1998. The case study provides evidence that “greed” and “grievance” can be interlinked (such as in 1992 and confirms the relevance of leadership and external interventions mechanisms.

  8. American alliances and nuclear non-proliferation. The end of nuclear weapon activities of US allies; Amerikanische Allianzen und nukleare Nichtverbreitung. Die Beendigung von Kernwaffenaktivitaeten bei Verbuendeten der USA

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, Jonas

    2016-07-01

    Jonas Schneider tackles a question that is of great interest both to scholars of nuclear proliferation and to practitioners of nonproliferation diplomacy: Why do some political leaders of U.S. allies agree to abandon their nation's nuclear weapons activities, while others - who are often members of the same allied government and sometimes even of the same political party - steadfastly reject such a course reversal? Our existing stock of theories does not fare well in accounting for this important variation in leaders' attitudes. To solve this puzzle, Schneider develops an innovative theory that draws on the individual status conceptions of allied political leaders. Subsequently, the author undertakes to test his theory using four thoroughly researched case studies, and he derives important lessons for international nonproliferation diplomacy toward the Middle East and Northeast Asia.

  9. Maximally Generalized Yang-Mills Model and Dynamical Breaking of Gauge Symmetry

    International Nuclear Information System (INIS)

    Wang Dianfu; Song Heshan

    2006-01-01

    A maximally generalized Yang-Mills model, which contains, besides the vector part V μ , also an axial-vector part A μ , a scalar part S, a pseudoscalar part P, and a tensor part T μν , is constructed and the dynamical breaking of gauge symmetry in the model is also discussed. It is shown, in terms of the Nambu-Jona-Lasinio mechanism, that the gauge symmetry breaking can be realized dynamically in the maximally generalized Yang-Mills model. The combination of the maximally generalized Yang-Mills model and the NJL mechanism provides a way to overcome the difficulties related to the Higgs field and the Higgs mechanism in the usual spontaneous symmetry breaking theory.

  10. Subquark model of leptons and quarks

    International Nuclear Information System (INIS)

    Terazawa, Hidezumi.

    1979-09-01

    1) First, various subquark models so far proposed are briefly reviewed. Classifications of leptons and quarks in the models and their comparison are made. Our spinor-subquark model of leptons and quarks in which leptons and quarks are made of three subquarks of spin 1/2 is discussed in detail. 2) The possibility that guage bosons and Higgs scalars are also made of a subquark-antisubquark pair is discussed. 3) Exotic states of subquarks such as leptons and quarks of spin 3/2, exotic fermions, and exotic bosons are predicted in our model. 4) Subquark currents and their algebra are proposed. 5) Two unified subquark models of strong and electroweak interactions are discussed. The one is a gauge model and the other is a model of the Nambu-Jona-Lasinio type. 6) A subquark model of gravity and its supergrand unification is proposed. 7) An finally, a speculation is made on ''color-space correspondence''. (author)

  11. Interplay between chiral symmetry breaking and color superconductivity in dense quark matter

    International Nuclear Information System (INIS)

    Kitazawa, Masakiyo

    2003-01-01

    We investigate the QCD phase diagram in finite temperature and density in a simple Nambu-Jona-Lasinio model with the vector interaction. It is shown that the repulsive density-density interaction coming from the vector term enhances competition between the chiral symmetry breaking (χSB) and color superconducting (CSC) phase transition: When the vector coupling is increased, the first order transition between the χSB and CSC phase becomes weaker, and the coexisting phase in which both the chiral and color-gauge symmetries are dynamically broken comes to exist in a wider region in the T-μ plane. We find that the critical line of the first order transition can have two endpoints for an intermediate range of the vector coupling. (author)

  12. Baryon number fluctuations and the phase structure in the PNJL model

    Energy Technology Data Exchange (ETDEWEB)

    Shao, Guo-yun; Tang, Zhan-duo; Gao, Xue-yan; He, Wei-bo [Xi' an Jiaotong University, School of Science, Xi' an, Shaanxi (China)

    2018-02-15

    We investigate the kurtosis and skewness of net-baryon number fluctuations in the Polyakov loop extended Nambu-Jona-Lasinio (PNJL) model, and discuss the relations between fluctuation distributions and the phase structure of quark-gluon matter. The calculation shows that the traces of chiral and deconfinement transitions can be effectively reflected by the kurtosis and skewness of net-baryon number fluctuations not only in the critical region but also in the crossover region. The contour plot of baryon number kurtosis derived in the PNJL model can qualitatively explain the behavior of net-proton number kurtosis in the STAR beam energy scan experiments. Moreover, the three-dimensional presentations of the kurtosis and skewness in this study are helpful to understand the relations between baryon number fluctuations and QCD phase structure. (orig.)

  13. Strong UA(1) breaking in radiative η decays

    International Nuclear Information System (INIS)

    Takizawa, M.; Nemoto, Y.; Oka, M.

    1996-08-01

    We study the η → γγ, η → γμ - μ + and η → π 0 γγ decays using an extended three-flavor Nambu-Jona-Lasinio model that includes the 't Hooft instanton induced interaction. We find that the η-meson mass, the η → γγ, η → γμ - μ + and η → π 0 γγ decay widths are in good agreement with the experimental values when the U A (1) breaking is strong and the flavor SU(3) singlet-octet mixing angle θ is about zero. The calculated ηγγ * transition form factor has somewhat weaker dependence on the squared four-momentum of the virtual photon. The effects of the U A (1) anomaly on the scalar quark contents in the nucleon, the Σ πN and Σ KN terms and the baryon number one and two systems are also studied. (author)

  14. Elastic scattering and transport coefficients for a quark plasma in SUf(3) at finite temperatures

    Science.gov (United States)

    Rehberg, P.; Klevansky, S. P.; Hüfner, J.

    1996-02-01

    The temperature dependence of the elastic-scattering processes qq' → qq' and q overlineq' → q overlineq' , with q, q' = u, d, s is studied as a function of the scattering angle and the center-of-mass energy of the collision within the framework of the SUf(3) Nambu-Jona-Lasinio model. Critical scattering at threshold is observed in the q overlineq' → q overlineq' process, leading to an enhancement of the cross section as occurs in the phenomenon of critical opalescence. Transport properties such as viscosity, mean free paths and thermal relaxation times are calculated. Strangeness enhancement is investigated via the chemical relaxation times, which are found to be considerably higher than those calculated via perturbative QCD. A comparison with the experimental values for the strangeness enhancement in S + S collisions leads to an upper limit of 4 fm/ c for the lifetime of the plasma.

  15. Ab initio calculation of a global potential, vibrational energies, and wave functions for HCN/HNC, and a simulation of the (A-tilde)-(X-tilde) emission spectrum

    Science.gov (United States)

    Bowman, Joel M.; Gazdy, Bela; Bentley, Joseph A.; Lee, Timothy J.; Dateo, Christopher E.

    1993-01-01

    A potential energy surface for the HCN/HNC system which is a fit to extensive, high-quality ab initio, coupled-cluster calculations is presented. All HCN and HNC states with energies below the energy of the first delocalized state are reported and characterized. Vibrational transition energies are compared with all available experimental data on HCN and HNC, including high CH-overtone states up to 23,063/cm. A simulation of the (A-tilde)-(X-tilde) stimulated emission pumping (SEP) spectrum is also reported, and the results are compared to experiment. Franck-Condon factors are reported for odd bending states of HCN, with one quantum of vibrational angular momentum, in order to compare with the recent assignment by Jonas et al. (1992), on the basis of axis-switching arguments of a number of previously unassigned states in the SEP spectrum.

  16. Critical constraints on chiral hierarchies

    International Nuclear Information System (INIS)

    Chivukula, R.S.; Golden, M.; Simmons, E.H.

    1993-01-01

    Critical dynamics constrains models of dynamical electroweak symmetry breaking in which the scale of high-energy physics is far above 1 TeV. A big hierarchy requires the high-energy theory to have a second-order chiral phase transition, near which the theory is described by a low-energy effective Lagrangian with composite ''Higgs'' scalars. As scalar theories with more than one Φ 4 coupling can have a Coleman-Weinberg instability and a first-order transition, such dynamical EWSB models cannot always support a large hierarchy. If the large-N c Nambu--Jona-Lasinio model is a good approximation to the top-condensate and strong extended technicolor models, they will not produce acceptable EWSB

  17. Top and Higgs masses from dynamical electroweak symmetry breaking

    International Nuclear Information System (INIS)

    Kahana, D.E.

    1993-01-01

    The standard model of electroweak interactions, with the gauge and Higgs bosons appearing as composites, is derived from a Nambu-Jona-Lasinio-type four-fermion interaction, assumed to be valid above a high scale μ. Simple relationships are found for the composite boson top quark mass ratios and for the weak angle. Assuming three generations and a 'desert' hypothesis, these relationships are evolved with the full renormalization group down to present experimental energies, yielding predictions for the top quark and Higgs-boson masses, near 155 GeV for the former and near 140 GeV for the latter. In this fashion, fermion-antifermion condensates can be shown to yield a top mass consistent with that indicated from electroweak loop corrections for LEP data. (author) 23 refs

  18. RELAÇÕES ENTRE ÉTICA ORGANIZACIONAL, INOVAÇÕES AMBIENTAIS E SUSTENTABILIDADE

    OpenAIRE

    Pedro Gilberto Aloise

    2017-01-01

    O objetivo deste artigo é analisar o comportamento ético das organizações em relação a sustentabilidade e as inovações ambientais, através de uma revisão da literatura.  O estudo buscou identificar a convergência entre o conceito de desenvolvimento sustentável e as ideias de Kant, Georgescu-Roegen e Jonas, contextualizando as bases filosóficas do comportamento ético e o praticado pelas organizações. Em seguida apresentam-se as principais características das inovações sustentáveis e sua import...

  19. Fierz-complete NJL model study. II. Toward the fixed-point and phase structure of hot and dense two-flavor QCD

    Science.gov (United States)

    Braun, Jens; Leonhardt, Marc; Pospiech, Martin

    2018-04-01

    Nambu-Jona-Lasinio-type models are often employed as low-energy models for the theory of the strong interaction to analyze its phase structure at finite temperature and quark chemical potential. In particular, at low temperature and large chemical potential, where the application of fully first-principles approaches is currently difficult at best, this class of models still plays a prominent role in guiding our understanding of the dynamics of dense strong-interaction matter. In this work, we consider a Fierz-complete version of the Nambu-Jona-Lasinio model with two massless quark flavors and study its renormalization group flow and fixed-point structure at leading order of the derivative expansion of the effective action. Sum rules for the various four-quark couplings then allow us to monitor the strength of the breaking of the axial UA(1 ) symmetry close to and above the phase boundary. We find that the dynamics in the ten-dimensional Fierz-complete space of four-quark couplings can only be reduced to a one-dimensional space associated with the scalar-pseudoscalar coupling in the strict large-Nc limit. Still, the interacting fixed point associated with this one-dimensional subspace appears to govern the dynamics at small quark chemical potential even beyond the large-Nc limit. At large chemical potential, corrections beyond the large-Nc limit become important, and the dynamics is dominated by diquarks, favoring the formation of a chirally symmetric diquark condensate. In this regime, our study suggests that the phase boundary is shifted to higher temperatures when a Fierz-complete set of four-quark interactions is considered.

  20. Transport coefficients of strongly interacting matter

    International Nuclear Information System (INIS)

    Heckmann, Klaus

    2011-01-01

    In this thesis, we investigate the dissipative transport phenomena of strongly interacting matter. The special interest is in the shear viscosity and its value divided by entropy density. The performed calculations are based on effective models for Quantum Chromodynamics, mostly focused on the 2-flavor Nambu-Jona-Lasinio model. This allows us to study the hadronic sector as well as the quark sector within one single model. We expand the models up to next-to-leading order in inverse numbers of colors. We present different possibilities of calculating linear transport coefficients and give an overview over qualitative properties as well as over recent ideas concerning ideal fluids. As present methods are not able to calculate the quark two-point function in Minkowski space-time in the self-consistent approximation scheme of the Nambu-Jona-Lasinio model, a new method for this purpose is developed. This self-energy parametrization method is applied to the expansion scheme, yielding the quark spectral function with meson back-coupling effects. The usage of this spectral function in the transport calculation is only one result of this work. We also test the application of different transport approaches in the NJL model, and find an interesting behavior of the shear viscosity at the critical end point of the phase diagram. We also use the NJL model to calculate the viscosity of a pion gas in the dilute regime. After an analysis of other models for pions and their interaction, we find that the NJL-result leads to an important modification of transport properties in comparison with the calculations which purely rely on pion properties in the vacuum. (orig.)

  1. Musculo-nasomucosal unit with complete lateral bony freeing and medial rotation for ideal C-shape restoration and retropositioning of the levator veli palatini.

    Science.gov (United States)

    El-Shazly, Mohamed

    2012-11-01

    No definitive procedure for cleft repair has been identified yet as the gold standard. Accordingly, this work tried to appraise the hypothesis that if the bony detachment and full retropositioning of the levator veli palatini muscle can ideally present an anatomical C-shape muscular sling restoration and if this is accompanied with pushback palatoplasty, would this present a better result in terms of tissue fistulation and phonetic impairment? A series of 74 different degrees of palatal clefts were operated by pushback palatoplasty combined with a modified approach of the levator vili palatini. This muscle was dissected only from the oral mucosa while kept attached to the nasal one as a musculo-nasomucosal unit. This unit was completely detached from the bony margin of the hard palate and then medially rotated and retropositioned in a typical C-shape mobile sling. Evaluations included suture line assessment and fistula development, and following the child's need for speech therapy. There were no intraoperative complications. Definite anterior fistulae with nasal air and foot leakage were observed in 2 cases. Four cases had postoperative velopharyngeal incompetence with a need for speech therapy. Tension-free closure, lower risk of fistula, good restoration of velopharyngeal functions, ability to be performed on all cleft types, ability to provide a good intraoperative exposure, and being a single stage seem to be the most important advantages of this unpublished technique.

  2. Mitochondrial Targeted Endonuclease III DNA Repair Enzyme Protects against Ventilator Induced Lung Injury in Mice

    Directory of Open Access Journals (Sweden)

    Masahiro Hashizume

    2014-08-01

    Full Text Available The mitochondrial targeted DNA repair enzyme, 8-oxoguanine DNA glycosylase 1, was previously reported to protect against mitochondrial DNA (mtDNA damage and ventilator induced lung injury (VILI. In the present study we determined whether mitochondrial targeted endonuclease III (EndoIII which cleaves oxidized pyrimidines rather than purines from damaged DNA would also protect the lung. Minimal injury from 1 h ventilation at 40 cmH2O peak inflation pressure (PIP was reversed by EndoIII pretreatment. Moderate lung injury due to ventilation for 2 h at 40 cmH2O PIP produced a 25-fold increase in total extravascular albumin space, a 60% increase in W/D weight ratio, and marked increases in MIP-2 and IL-6. Oxidative mtDNA damage and decreases in the total tissue glutathione (GSH and the GSH/GSSH ratio also occurred. All of these indices of injury were attenuated by mitochondrial targeted EndoIII. Massive lung injury caused by 2 h ventilation at 50 cmH2O PIP was not attenuated by EndoIII pretreatment, but all untreated mice died prior to completing the two hour ventilation protocol, whereas all EndoIII-treated mice lived for the duration of ventilation. Thus, mitochondrial targeted DNA repair enzymes were protective against mild and moderate lung damage and they enhanced survival in the most severely injured group.

  3. [IDENTIFICATION OF CAUSES OF EARLY PREGNANCY LOSSES ACCORDING TO HYSTOMORPHOLOGIC FEATURES].

    Science.gov (United States)

    Gotsiridze, K; Kintraia, N; Pailodze, M; Gogia, T; Tsaava, F

    2017-01-01

    Retrospective analysis of the early spontaneous abortions has been conducted (486 cases). Histomorphologic analysis of the curettage material contents erveledinvolutive-regressive developmental chsnges in 108 (22,28%) cases, in 370 cases (77.78%) pathologic changes, like inflammatory changes of deciduas and chorionic villis in 302 cases (80.2%), pathologic prematurity of chorionic vili in 48 cases (12.6%), hydatidiform mole in 28 cases (7.4%). As most cases of pregnancy loss has been reported at 7-9 weeks /172 cases/, we compared histomorphologic data revealed at 7-8 (71 cases) weeks to 5-6 (135 cases) and 10-12 weeks of gestation. Morphologic research data confimed, that at 7-8 weeks compared to 5-6 weeks leading reason ofpregnancy loss was inflammatory changes (OR-1,584), what can be cause of 110 pregnancy losses at 1000 pregnant women (AR-0.11). Data comparing7-9 weeks to 10-12 weeks pregnancy losses, confirm the priority of pathologic immaturity (OR-1,279) and hydatidiform mole (OR-1,557) and could be the risk of 100 cases of pregnancy termination at 1000 pregnant women (AR-0.10).Existing results are of great importance for the preconceptional preparation of women.

  4. Training for cervical cancer prevention programs in low-resource settings: focus on visual inspection with acetic acid and cryotherapy.

    Science.gov (United States)

    Blumenthal, P D; Lauterbach, M; Sellors, J W; Sankaranarayanan, R

    2005-05-01

    The modern approach to cervical cancer prevention, characterized by use of cytology and multiple visits for diagnosis and treatment, has frequently proven challenging and unworkable in low-resource settings. Because of this, the Alliance for Cervical Cancer Prevention (ACCP) has made it a priority to investigate and assess alternative approaches, particularly the use of visual screening methods, such as visual inspection with acetic acid (VIA) and visual inspection with Lugol's iodine (VILI), for precancer and cancer detection and the use of cryotherapy as a precancer treatment method. As a result of ACCP experience in providing training to nurses and doctors in these techniques, it is now widely agreed that training should be competency based, combining both didactic and hands-on approaches, and should be done in a clinical setting that resembles the service-delivery conditions at the program site. This article reviews ACCP experiences and perceptions about the essentials of training in visual inspection and cryotherapy and presents some lessons learned with regard to training in these techniques in low-resource settings.

  5. Effect of Electrode Belt and Body Positions on Regional Pulmonary Ventilation- and Perfusion-Related Impedance Changes Measured by Electric Impedance Tomography.

    Directory of Open Access Journals (Sweden)

    Elin Ericsson

    Full Text Available Ventilator-induced or ventilator-associated lung injury (VILI/VALI is common and there is an increasing demand for a tool that can optimize ventilator settings. Electrical impedance tomography (EIT can detect changes in impedance caused by pulmonary ventilation and perfusion, but the effect of changes in the position of the body and in the placing of the electrode belt on the impedance signal have not to our knowledge been thoroughly evaluated. We therefore studied ventilation-related and perfusion-related changes in impedance during spontaneous breathing in 10 healthy subjects in five different body positions and with the electrode belt placed at three different thoracic positions using a 32-electrode EIT system. We found differences between regions of interest that could be attributed to changes in the position of the body, and differences in impedance amplitudes when the position of the electrode belt was changed. Ventilation-related changes in impedance could therefore be related to changes in the position of both the body and the electrode belt. Perfusion-related changes in impedance were probably related to the interference of major vessels. While these findings give us some insight into the sources of variation in impedance signals as a result of changes in the positions of both the body and the electrode belt, further studies on the origin of the perfusion-related impedance signal are needed to improve EIT further as a tool for the monitoring of pulmonary ventilation and perfusion.

  6. Effects of positive end-expiratory pressure and recruitment maneuvers in a ventilator-induced injury mouse model.

    Directory of Open Access Journals (Sweden)

    Laura A Cagle

    Full Text Available Positive-pressure mechanical ventilation is an essential therapeutic intervention, yet it causes the clinical syndrome known as ventilator-induced lung injury. Various lung protective mechanical ventilation strategies have attempted to reduce or prevent ventilator-induced lung injury but few modalities have proven effective. A model that isolates the contribution of mechanical ventilation on the development of acute lung injury is needed to better understand biologic mechanisms that lead to ventilator-induced lung injury.To evaluate the effects of positive end-expiratory pressure and recruitment maneuvers in reducing lung injury in a ventilator-induced lung injury murine model in short- and longer-term ventilation.5-12 week-old female BALB/c mice (n = 85 were anesthetized, placed on mechanical ventilation for either 2 hrs or 4 hrs with either low tidal volume (8 ml/kg or high tidal volume (15 ml/kg with or without positive end-expiratory pressure and recruitment maneuvers.Alteration of the alveolar-capillary barrier was noted at 2 hrs of high tidal volume ventilation. Standardized histology scores, influx of bronchoalveolar lavage albumin, proinflammatory cytokines, and absolute neutrophils were significantly higher in the high-tidal volume ventilation group at 4 hours of ventilation. Application of positive end-expiratory pressure resulted in significantly decreased standardized histology scores and bronchoalveolar absolute neutrophil counts at low- and high-tidal volume ventilation, respectively. Recruitment maneuvers were essential to maintain pulmonary compliance at both 2 and 4 hrs of ventilation.Signs of ventilator-induced lung injury are evident soon after high tidal volume ventilation (as early as 2 hours and lung injury worsens with longer-term ventilation (4 hrs. Application of positive end-expiratory pressure and recruitment maneuvers are protective against worsening VILI across all time points. Dynamic compliance can be used guide

  7. Feasibility and safety of low-flow extracorporeal carbon dioxide removal to facilitate ultra-protective ventilation in patients with moderate acute respiratory distress sindrome.

    Science.gov (United States)

    Fanelli, Vito; Ranieri, Marco V; Mancebo, Jordi; Moerer, Onnen; Quintel, Michael; Morley, Scott; Moran, Indalecio; Parrilla, Francisco; Costamagna, Andrea; Gaudiosi, Marco; Combes, Alain

    2016-02-10

    Mechanical ventilation with a tidal volume (VT) of 6 mL/kg/predicted body weight (PBW), to maintain plateau pressure (Pplat) lower than 30 cmH2O, does not completely avoid the risk of ventilator induced lung injury (VILI). The aim of this study was to evaluate safety and feasibility of a ventilation strategy consisting of very low VT combined with extracorporeal carbon dioxide removal (ECCO2R). In fifteen patients with moderate ARDS, VT was reduced from baseline to 4 mL/kg PBW while PEEP was increased to target a plateau pressure--(Pplat) between 23 and 25 cmH2O. Low-flow ECCO2R was initiated when respiratory acidosis developed (pH 60 mmHg). Ventilation parameters (VT, respiratory rate, PEEP), respiratory compliance (CRS), driving pressure (DeltaP = VT/CRS), arterial blood gases, and ECCO2R system operational characteristics were collected during the period of ultra-protective ventilation. Patients were weaned from ECCO2R when PaO2/FiO2 was higher than 200 and could tolerate conventional ventilation settings. Complications, mortality at day 28, need for prone positioning and extracorporeal membrane oxygenation, and data on weaning from both MV and ECCO2R were also collected. During the 2 h run in phase, VT reduction from baseline (6.2 mL/kg PBW) to approximately 4 mL/kg PBW caused respiratory acidosis (pH protective mechanical ventilation strategy in patients with moderate ARDS.

  8. Effects of positive end-expiratory pressure and recruitment maneuvers in a ventilator-induced injury mouse model

    Science.gov (United States)

    Franzi, Lisa M.; Linderholm, Angela L.; Last, Jerold A.; Adams, Jason Y.; Harper, Richart W.

    2017-01-01

    Background Positive-pressure mechanical ventilation is an essential therapeutic intervention, yet it causes the clinical syndrome known as ventilator-induced lung injury. Various lung protective mechanical ventilation strategies have attempted to reduce or prevent ventilator-induced lung injury but few modalities have proven effective. A model that isolates the contribution of mechanical ventilation on the development of acute lung injury is needed to better understand biologic mechanisms that lead to ventilator-induced lung injury. Objectives To evaluate the effects of positive end-expiratory pressure and recruitment maneuvers in reducing lung injury in a ventilator-induced lung injury murine model in short- and longer-term ventilation. Methods 5–12 week-old female BALB/c mice (n = 85) were anesthetized, placed on mechanical ventilation for either 2 hrs or 4 hrs with either low tidal volume (8 ml/kg) or high tidal volume (15 ml/kg) with or without positive end-expiratory pressure and recruitment maneuvers. Results Alteration of the alveolar-capillary barrier was noted at 2 hrs of high tidal volume ventilation. Standardized histology scores, influx of bronchoalveolar lavage albumin, proinflammatory cytokines, and absolute neutrophils were significantly higher in the high-tidal volume ventilation group at 4 hours of ventilation. Application of positive end-expiratory pressure resulted in significantly decreased standardized histology scores and bronchoalveolar absolute neutrophil counts at low- and high-tidal volume ventilation, respectively. Recruitment maneuvers were essential to maintain pulmonary compliance at both 2 and 4 hrs of ventilation. Conclusions Signs of ventilator-induced lung injury are evident soon after high tidal volume ventilation (as early as 2 hours) and lung injury worsens with longer-term ventilation (4 hrs). Application of positive end-expiratory pressure and recruitment maneuvers are protective against worsening VILI across all time points

  9. Correction: Crime: Social risk in contemporary society (2017, vol 7, no 13, p. 84-113

    Directory of Open Access Journals (Sweden)

    Uredništvo

    2017-01-01

    Full Text Available Due to a technical mistake, the correct abstract in Serbian language of the article authored by dr. Dragana Vilić 'Crime - Social risk in contemporary society' published in the journal Politeia (issue number 13, vol. 7, p.84 was omitted. The Editorial board apologises to the author and our readers. With the consent of the author, we publish the correct summary in Serbian language in this issue: Summary Crime, as a form of violation of law (A. Giddens, is one of the social risks. One of the negative consequences of the development of a modern, global society is the globalization of criminality (M. Kostić & F. Mirić. Criminality can only be discussed with the development and elaboration of the legal system in the modern sense of the word (including criminal law, but in societies there have always been certain types of norms and beliefs that have influenced human behavior and against which (in correctness (M. Ivanović. Unlike a positive right that cannot fully follow the dynamics of change in society that influence the definition of a crime, sociology should constantly seek new elements that extend this notion (new, unpredictable, unlimited. The paper analyzes the causes of criminality, its distribution, types (violent, property, etc., relation to other notions (deviance, delinquency and crime and its consequences in contemporary society, in order to look at the risk of crime, to seek an adequate social response to This negative phenomenon, and provides an analysis of the penal policy and the role of a prison institution for the offender's conversion (M. Foucault.

  10. Atlantic technology for Mediterranean Gods. The Lebrija type gold 'candelabra'

    Directory of Open Access Journals (Sweden)

    Perea, Alicia

    2003-06-01

    Full Text Available The Lebrija (Seville hoard, made up of six identical objects, was thought to be unique in its kind until a new specimen came out of the antiquities market, repeating .the morphology and the fabrication technique of the so called candelabra. We have completed a technological, functional and symbolic study, as well as the elemental analysis of the objects by PIXE. In our opinion they were all manufactured by local people at the beginning of the interaction between Phoenicians and Tartesians during the 8th century B. C. Concerning their function, we cannot accept the interpretation as incense burners any more; we prefer to think of them as aniconic representations of the divinity following phoenician mythology.

    El depósito de Lebrija (Sevilla compuesto por seis objetos iguales se creía único en su género hasta la aparición en el mercado de antigüedades de un nuevo ejemplar que repite la morfología y técnica de fabricación de estos llamados candelabros. Hemos estudiado los siete ejemplares desde el punto de vista tecnológico, funcional y simbólico, además de realizar análisis de composición mediante el método PlXE. Creemos que se trata de una serie de piezas de fabricación indígena en los primeros momentos de contacto entre fenicios y tartésicos, hacia el siglo VIlI a.C. En cuanto a su funcionalidad, no se puede seguir aceptando su interpretación como incensarios, sino que fueron la representación anicónica de la divinidad según la mitología fenicia.

  11. Early detection of cervical cancer with visual inspection methods: a summary of completed and on-going studies in India Detección oportuna de cáncer cervical con métodos de inspección visual: un resumen de estudios en India

    Directory of Open Access Journals (Sweden)

    R Sankaranarayanan

    2003-01-01

    Full Text Available India is a high-risk country for cervical cancer which accounts a quarter (126 000 new cases, 71 000 deaths around 2 000 of the world burden. The age-standardized incidence rates range from 16-55 per 100 000 women in different regions with particularly high rates in rural areas. Control of cervical cancer by early detection and treatment is a priority of the National Cancer Control Programme of India. There are no organized cytology screening programmes in the country. The technical and financial constraints to organize cytology screening have encouraged the evaluation of visual inspection approaches as potential alternatives to cervical cytology in India. Four types of visual detection approaches for cervical neoplasia are investigated in India: a naked eye inspection without acetic acid application, widely known as 'downstaging'; b naked eye inspection after application of 3-5% acetic acid (VIA; c VIA using magnification devices (VIAM; d visual inspection after the application of Lugol's iodine (VILI. Downstaging has been shown to be poorly sensitive and specific to detect cervical neoplasia and is no longer considered as a suitable screening test for cervical cancer. VIA, VIAM and VILI are currently being investigated in multicentre cross-sectional studies (without verification bias, in which cytology and HPV testing are also simultaneously evaluated, and the results of these investigations will be available in 2003. These studies will provide valuable information on the average, comparative test performances in detecting high-grade cervical cancer precursors and cancer. Results from pooled analysis of data from two completed studies indicated an approximate sensitivity of 93.4% and specificity of 85.1% for VIA to detect CIN 2 or worse lesions; the corresponding figures for cytology were 72.1% and 91.6%. The efficacy of VIA in reducing incidence of and mortality from cervical cancer and its cost-effectiveness is currently being investigated

  12. Knowledge and practices of general practitioners at district hospitals towards cervical cancer prevention in Burundi, 2015: a cross-sectional study.

    Science.gov (United States)

    Ndizeye, Zacharie; Vanden Broeck, Davy; Vermandere, Heleen; Bogers, John Paul; Van Geertruyden, Jean-Pierre

    2018-01-16

    Well-organized screening and treatment programmes are effective to prevent Invasive Cervical Cancer (ICC) in LMICs. To achieve this, the World Health Organization (WHO) recommends the involvement of existing health personnel in casu doctors, nurses, midwives in ICC prevention. A necessary precondition is that health personnel have appropriate knowledge about ICC. Therefore, to inform policy makers and training institutions in Burundi, we documented the knowledge and practices of general practitioners (GPs) at district hospital level towards ICC control. A descriptive cross-sectional survey was conducted from February to April, 2015 among all GPs working in government district hospitals. A structured questionnaire and a scoring system were used to assess knowledge and practices of GPs. The participation rate was 58.2%. Majority of GPs (76.3%) had appropriate knowledge (score > 70%) on cervical cancer disease; but some risk factors were less well known as smoking and the 2 most important oncogenic HPV. Only 8.4% of the participants had appropriate knowledge on ICC prevention: 55% of the participants were aware that HPV vaccination exists and 48.1% knew cryotherapy as a treatment method for CIN. Further, 15.3% was aware of VIA as a screening method. The majority of the participants (87%) never or rarely propose screening tests to their clients. Only 2 participants (1.5%) have already performed VIA/VILI. Wrong thoughts were also reported: 39.7% thought that CIN could be treated with radiotherapy; 3.1% thought that X-ray is a screening method. In this comprehensive assessment, we observed that Burundian GPs have a very low knowledge level about ICC prevention, screening and treatment. Suboptimal practices and wrong thoughts related to ICC screening and treatments have also been documented. We therefore recommend an adequate pre- and in-service training of GPs and most probably nurses on ICC control before setting up any public health intervention on ICC control.

  13. Effects of positive end-expiratory pressure and recruitment maneuvers in a ventilator-induced injury mouse model.

    Science.gov (United States)

    Cagle, Laura A; Franzi, Lisa M; Linderholm, Angela L; Last, Jerold A; Adams, Jason Y; Harper, Richart W; Kenyon, Nicholas J

    2017-01-01

    Positive-pressure mechanical ventilation is an essential therapeutic intervention, yet it causes the clinical syndrome known as ventilator-induced lung injury. Various lung protective mechanical ventilation strategies have attempted to reduce or prevent ventilator-induced lung injury but few modalities have proven effective. A model that isolates the contribution of mechanical ventilation on the development of acute lung injury is needed to better understand biologic mechanisms that lead to ventilator-induced lung injury. To evaluate the effects of positive end-expiratory pressure and recruitment maneuvers in reducing lung injury in a ventilator-induced lung injury murine model in short- and longer-term ventilation. 5-12 week-old female BALB/c mice (n = 85) were anesthetized, placed on mechanical ventilation for either 2 hrs or 4 hrs with either low tidal volume (8 ml/kg) or high tidal volume (15 ml/kg) with or without positive end-expiratory pressure and recruitment maneuvers. Alteration of the alveolar-capillary barrier was noted at 2 hrs of high tidal volume ventilation. Standardized histology scores, influx of bronchoalveolar lavage albumin, proinflammatory cytokines, and absolute neutrophils were significantly higher in the high-tidal volume ventilation group at 4 hours of ventilation. Application of positive end-expiratory pressure resulted in significantly decreased standardized histology scores and bronchoalveolar absolute neutrophil counts at low- and high-tidal volume ventilation, respectively. Recruitment maneuvers were essential to maintain pulmonary compliance at both 2 and 4 hrs of ventilation. Signs of ventilator-induced lung injury are evident soon after high tidal volume ventilation (as early as 2 hours) and lung injury worsens with longer-term ventilation (4 hrs). Application of positive end-expiratory pressure and recruitment maneuvers are protective against worsening VILI across all time points. Dynamic compliance can be used guide the frequency

  14. Human-induced geomorphology: Modeling slope failure in Dominical, Costa Rica using Landsat imagery

    Science.gov (United States)

    Miller, Andrew J.

    Unchecked human development has ravaged the region between Dominical and Uvita, Costa Rica. Much of the development transition has been driven by tourism and further foreign direct investment in residential, service and commercial enterprises. The resulting land-use/land-cover change has removed traditional forest cover in exchange for impervious surfaces, physical structures, and bare ground which is no longer mechanically supported by woody vegetation. Combined with a tropical climate, deeply weathered soils and lithography which are prone to erosion, land cover change has led to an increase in slope failure occurrences. Given the remoteness of the Dominical-Uvita region, its rate of growth and the lack of monitoring, new techniques for monitoring land use and slope failure susceptibility are needed. Two new indices are presented here that employ a Digital Elevation Model (DEM) and widely available Landsat imagery to assist in this endeavor. The first index, or Vegetation Influenced Landslide Index (VILI), incorporates slope derived from a DEM and Lu et al.'s (2007) Surface Cover Index to quantify vegetative cover as a means of mechanical stabilization in landslide prone areas. The second index, or Slope Multiplier Index (SMI), uses individual Landsat data bands and basic Landsat band ratios as environmental proxies to replicate soil, vegetative and hydrologic properties. Both models achieve accuracy over 70% and rival results from more complicated published literature. The accuracy of the indices was assessed with the creation of a landslide inventory developed from field observations occurring in December 2007 and November 2008. The creation of these indices represents an efficient and accurate way of determining landslide susceptibility zonation in data poor areas where environmental protection practitioners may be overextended, under-trained or both.

  15. Ética de las biotecnologías

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    Cortina, Adela

    2002-12-01

    Full Text Available The power that New Genetics has placed within mankind=s grasp requires ethics from which decisions on matters of genetic manipulation can be made. This work sets out to (1 place the ethics of biotechnologies in the context of bioethics as a whole; (2 point out the different spheres of New Genetics which pose ethical problems, recognising that each of these requires specific treatment; (3 outline an ethical framework to guide replies, a structure built up from Kantian ethics, Sen=s capabilities approach, the ethics of discourse and Jonas= responsibility principle, and (4 to tackle what is perhaps the most burning question in the ethical sphere: if the power of genetic manipulation requires once more bringing up the discussion on human nature, as approached by Habermas and Fukuyama, amongst others.

    El poder que la Nueva Genética ha puesto en manos de los seres humanos requiere una ética desde la que sea posible tomar decisiones en cuestiones de manipulación genética. El trabajo se propone (1 situar la ética de las biotecnologías en el conjunto de la bioética, (2 señalar los distintos ámbitos de la Nueva Genética que plantean problemas éticos, reconociendo que cada uno de ellos requiere un tratamiento específico, (3 esbozar un marco ético desde el que orientar las respuestas, un marco elaborado desde la ética kantiana, el enfoque de las capacidades de Sen, la ética del discurso y el principio responsabilidad de Jonas, y (4 abordar la cuestión tal vez más candente en el ámbito ético: si el poder de la manipulación genética exige poner de nuevo sobre el tapete la discusión sobre la naturaleza humana, como hacen, entre otros, Habermas y Fukuyama.

  16. Responsabilidade civil do Estado por omissão estatal Civil liability of the State for environmental neglect

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    Haide Maria Hupffer

    2012-06-01

    Full Text Available Constituição Federal de 1988 é um divisor de águas ao assumir-se como Constituição Ambiental, provocando uma ruptura em relação ao conceito de responsabilidade civil. Partindo de uma abordagem qualitativa, dialética e jurisprudencial, este artigo analisa o Princípio Responsabilidade desenvolvido por hans jonas e realiza um diálogo com o instituto da responsabilidade civil ambiental, identificando, com apoio na legislação constitucional e infraconstitucional, as controvérsias doutrinárias acerca da natureza da responsabilidade estatal (objetiva ou subjetiva frente a casos de omissão da administração pública e à ocorrência de dano ambiental. Conclui-se que o Superior Tribunal de Justiça assume uma dimensão mais alargada do conceito de responsabilidade civil do Estado, demonstrando uma tendência pela responsabilidade civil objetiva com base no risco. Assim, o Brasil, salvo algumas divergências doutrinárias, adota a responsabilidade civil objetiva do Estado pela teoria do risco administrativo alicerçada no ato ilícito e na aceitação do risco.The Federal Constitution of 1988 is a 'water divisor' since it assumes the role of Environmental Constitution, causing a rapture of the concept of civil liability. Starting from a qualitative, dialectical and jurisprudential approach, this article analyzes the Principle of Liability according to Hans Jonas in order to dialogue with the Institute of Civil Environmental Liability, identifying, with the support of the constitutional and infraconstitutional legislation, the doctrinary controversies about the nature of state liability (objective or subjective towards cases of neglect by the public administration and the event of environmental damage. It is possible to conclude that the Higher Court of Justice assumes a larger dimension of the civil liability of the State, thus showing the tendency towards the objective civil liability based on the risk. Therefore, Brazil, regarded some

  17. Birth weight, sex, and celiac disease: a nationwide twin study

    Directory of Open Access Journals (Sweden)

    Kuja-Halkola R

    2017-11-01

    Full Text Available Ralf Kuja-Halkola,1 Benjamin Lebwohl,1,2 Jonas Halfvarson,3 Louise Emilsson,4–6 Patrik K Magnusson,1 Jonas F Ludvigsson1,2,7,8 1Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; 2Department of Medicine, Celiac Disease Center, Columbia University Medical Center, Columbia University, New York, NY, USA; 3Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; 4Department of Health Management and Health Economy, Institute of Health and Society, University of Oslo, Oslo, Norway; 5Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; 6Centre for Clinical Research, Vårdcentralen Värmlands Nysäter, County Council of Värmland, Värmland, 7Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; 8Division of Epidemiology and Public Health, School of Medicine, City Hospital, University of Nottingham, Nottingham, UK Objective: Earlier research suggests that birth weight may be associated with celiac disease (CD, but the direction of association has been unclear potentially due to confounding effect from genetic and intrafamilial factors. Through within-twin analyses, we aimed to minimize confounding effects such as twins that share genetic and early environmental exposures.Materials and methods: Using the Swedish Twin Registry, we examined the birth weight of 146,830 twins according to the CD status. CD was defined as having villous atrophy according to a small intestinal biopsy reports.Results: The prevalence of diagnosed CD was 0.5% (n=669, and we included 407 discordant pairs of CD–non-CD twins. Comparing the 669 CD patients with non-CD twins, the association between birth weight and future CD was not statistically significant (odds ratio [OR] per 1000 g increase in birth weight: 1.16; 95% confidence interval [CI]=0.97–1.38. In males, the association was positive and statistically significant (OR=1.50; 95% CI

  18. Goldstone bosons in a crystalline chiral phase

    Energy Technology Data Exchange (ETDEWEB)

    Schramm, Marco

    2017-07-24

    The phase diagram of strong interaction matter is expected to exhibit a rich structure. Different models have shown, that crystalline phases with a spatially varying chiral condensate can occur in the regime of low temperatures and moderate densities, where they replace the first-order phase transition found for spatially constant order parameters. We investigate this inhomogeneous phase, where in addition to the chiral symmetry, translational and rotational symmetry are broken as well, in a two flavor Nambu--Jona-Lasinio model. The main goal of this work is to describe the Goldstone bosons in this phase, massless excitations that occur for spontaneously broken symmetries. We take one of the simplest possible modulations, the chiral density wave, and show how to derive the quark propagator of the theory analytically, by means of transformations in chiral and momentum space. We apply this to a test case for the gap equation. We show the derivation of Nambu-Goldstone modes in the inhomogeneous phase and find, that for our case only three different modes have to be taken into account. We proceed to calculate the Goldstone boson related to the breaking of spatial symmetry, which can be related to the neutral pion. By evaluating a Bethe-Salpeter equation, we can show, that we have indeed found a Goldstone boson and give its dispersion relation in terms of momenta perpendicular, as well as parallel to the mass modulation.

  19. Can Social Robots Qualify for Moral Consideration? Reframing the Question about Robot Rights

    Directory of Open Access Journals (Sweden)

    Herman T. Tavani

    2018-03-01

    Full Text Available A controversial question that has been hotly debated in the emerging field of robot ethics is whether robots should be granted rights. Yet, a review of the recent literature in that field suggests that this seemingly straightforward question is far from clear and unambiguous. For example, those who favor granting rights to robots have not always been clear as to which kinds of robots should (or should not be eligible; nor have they been consistent with regard to which kinds of rights—civil, legal, moral, etc.—should be granted to qualifying robots. Also, there has been considerable disagreement about which essential criterion, or cluster of criteria, a robot would need to satisfy to be eligible for rights, and there is ongoing disagreement as to whether a robot must satisfy the conditions for (moral agency to qualify either for rights or (at least some level of moral consideration. One aim of this paper is to show how the current debate about whether to grant rights to robots would benefit from an analysis and clarification of some key concepts and assumptions underlying that question. My principal objective, however, is to show why we should reframe that question by asking instead whether some kinds of social robots qualify for moral consideration as moral patients. In arguing that the answer to this question is “yes,” I draw from some insights in the writings of Hans Jonas to defend my position.

  20. Chiral symmetry breaking and the pion quark structure

    International Nuclear Information System (INIS)

    Bernard, V.

    1986-01-01

    The mechanism of dynamical breaking of chiral symmetry in hadronic matter is first studied in the framework of the Nambu and Jona-Lasinio model on one hand and its generalisation to finite hadron size on the other hand. The analysis uses a variational procedure modelled after the BCS superconductor. Our study indicates for example, a great sensitivity of various quantities characterizing the breaking of symmetry to the shape of the interaction. Also the mechanism of breaking of chiral symmetry is essentially related to the mechanism of confinement. When a symmetry is spontaneously broken, there exists a Goldstone particle of zero mass. This is true in our model. This particle, the pion, is obtained as solution of a Bethe Salpeter equation for a qantiq bound state. This enables us to establish a connection between the pion as a Goldstone boson related to spontaneous symmetry breaking and the quark-antiquark structure of the pion. The finite mass of the physical pion is obtained with non zero current quark mass. Various properties of this particle are then studied in the RPA formalism. One important point of our model is the highly collective character of the pion. 85 refs [fr

  1. Non-perturbative effective interactions in the standard model

    Energy Technology Data Exchange (ETDEWEB)

    Arbuzov, Boris A. [Moscow Lomonosov State Univ. (Russian Federation). Skobeltsyn Inst. of Nuclear Physics

    2014-07-01

    This monograph is devoted to the nonperturbative dynamics in the Standard Model (SM), the basic theory of allfundamental interactions in natureexcept gravity. The Standard Model is divided into two parts: the quantum chromodynamics (QCD) and the electro-weak theory (EWT) are well-defined renormalizable theories in which the perturbation theory is valid. However, for the adequate description of the real physics nonperturbative effects are inevitable. This book describes how these nonperturbative effects may be obtained in the framework of spontaneous generation of effective interactions. The well-known example of such effective interaction is provided by the famous Nambu-Jona-Lasinio effective interaction. Also a spontaneous generation of this interaction in the framework of QCD is described and applied to the method for other effective interactions in QCD and EWT. The method is based on N.N. Bogolyubov's conception of compensation equations. As a result we then describe the principal features of the Standard Model, e.g. Higgs sector, and significant nonperturbative effects including recent results obtained at LHC and TEVATRON.

  2. Electromagnetic properties of the pion as a composite Nambu-Goldstone boson

    International Nuclear Information System (INIS)

    Ito, H.; Buck, W.W.; Gross, F.

    1992-01-01

    Motivated by the Nambu--Jona-Lasinio model of light mesons, we introduce a covariant separable interaction to model the structure of relativistic quark-antiquark systems. The Schwinger-Dyson equation for the quark self-energy is solved analytically, generating a dynamical quark mass through spontaneous breaking of chiral symmetry, and yielding a pion which has zero mass in the chiral limit. The Bethe-Salpeter vertex function for this q bar q pion, which has a momentum distribution and composite structure associated with the interaction, is obtained analytically. Using this vertex function, and a similar one for the ρ meson, we calculate the electromagnetic observables of this composite Nambu-Goldstone boson, including effects from ρ-meson dominance processes. Our calculation takes the composite structure of the mesons into account. The ρ-meson effects are found to be very small in the pion charge form factor, but substantial in the charge radius. Using the model, predictions are made for γ * π 0 →γ and ρπγ transition form factors

  3. Nambu mechanism of dynamical symmetry breaking by the top quark

    Science.gov (United States)

    Pham, Xuan-Yem

    1990-05-01

    It may be possible that the gauge symmetry breaking of the standard electroweak interactions is not due to the elementary scalar Higgs fields but has a dynamic origin intimately involving the top quark. A prototype of this dynamical scenario is the Nambu and Jona-Lasinio model in which both the top quark and the gauge bosons become massive by some strong attractive nonlinear interactions similar to the gap energy produced in BCS superconductivity. Self-consistent equations for the charged Goldstone boson and for the vector meson are used to get an upper bound for the top quark mass. In the bubble approximation of keeping only fermion loops, we obtain an equation relating the top quark mass to the W boson one; from the top mass is found to be around 84 GeV. Its typical dominant decay mode t→W+s then follows. Also discussed are distinctive signatures of the scalar overlinett bound state identified as the physical Higgs particle whose mass is twice that of the top quark.

  4. Lattice gauge fixing as quenching and the violation of spectral positivity

    International Nuclear Information System (INIS)

    Aubin, C.; Ogilvie, Michael C.

    2004-01-01

    Lattice Landau gauge and other related lattice gauge-fixing schemes are known to violate spectral positivity. The most direct sign of the violation is the rise of the effective mass as a function of distance. The origin of this phenomenon lies in the quenched character of the auxiliary field g used to implement lattice gauge-fixing, and is similar to quenched QCD in this respect. This is best studied using the Parrinello Jona-Lasinio Zwanziger formalism, leading to a class of covariant gauges similar to the one-parameter class of covariant gauges commonly used in continuum gauge theories. Soluble models are used to illustrate the origin of the violation of spectral positivity. The phase diagram of the lattice theory, as a function of the gauge coupling β and the gauge-fixing parameter α, is similar to that of the unquenched theory, a Higgs model of a type first studied by Fradkin and Shenker. The gluon propagator is interpreted as yielding bound states in the confined phase, and a mixture of fundamental particles in the Higgs phase, but lattice simulation shows the two phases are connected. Gauge-field propagators from the simulation of an SU(2) lattice gauge theory on a 20 4 lattice are well described by a quenched mass-mixing model. The mass of the lightest state, which we interpret as the gluon mass, appears to be independent of α for sufficiently large α

  5. Polio and Nobel prizes: looking back 50 years.

    Science.gov (United States)

    Norrby, Erling; Prusiner, Stanley B

    2007-05-01

    In 1954, John Enders, Thomas Weller, and Frederick Robbins were awarded the Nobel Prize in Physiology or Medicine "for their discovery of the ability of poliomyelitis viruses to grow in cultures of various types of tissue."5370 This discovery provided for the first time opportunities to produce both inactivated and live polio vaccines. By searching previously sealed Nobel Committee archives, we were able to review the deliberations that led to the award. It appears that Sven Gard, who was Professor of Virus Research at the Karolinska Institute and an adjunct member of the Nobel Committee at the time, played a major role in the events leading to the awarding of the Prize. It appears that Gard persuaded the College of Teachers at the Institute to decide not to follow the recommendation by their Nobel Committee to give the Prize to Vincent du Vigneaud. Another peculiar feature of the 1954 Prize is that Weller and Robbins were included based on only two nominations submitted for the first time that year. In his speech at the Nobel Prize ceremony, Gard mentioned the importance of the discovery for the future production of vaccines, but emphasized the implications of this work for growing many different, medically important viruses. We can only speculate on why later nominations highlighting the contributions of scientists such as Jonas Salk, Hilary Koprowski, and Albert Sabin in the development of poliovirus vaccines have not been recognized by a Nobel Prize.

  6. [The history of polio in Sweden - from infantile paralysis to polio vaccine].

    Science.gov (United States)

    Axelsson, Per

    2004-01-01

    Although other epidemics declined due to improved hygiene and sanitation, legislation, and vaccination, polio epidemics appeared in Sweden in 1881 and at the turn of the 20th century the disease became and annual feature in the Swedish epidemiological pattern. Due to the vaccination starting in 1957 epidemics ceased to exist in Sweden around 1965. This article deals with the history polio epidemics in Sweden, 1880-1965 and gives a brief description of: the demographical influence of polio, how did the medical authorities investigate and try to combat it, and the different comprehensions of how polio affected its victims.A study of polio incidence in Sweden at the national level during 1905-1962 reveals that the disease caused major epidemics in 1911-1913 and 1953. At the beginning of the 20th century polio primarily attacked children up to 10 years of age, and at the end of the period victims were represented in all age groups, but mainly in the ages 20-39. Due to its enigmatic appearance, polio was not considered as an epidemic infectious disease during the 19th century. Sweden's early epidemics enabled Swedish medical science to act and together with American research institutes it acquired a leading role in international medical research on the disease. In the 1955 Jonas Salk produced the first successful vaccine against polio but also Sweden developed its own vaccine, different in choice of methods and materials from the widely used Salk-vaccine.

  7. Meeting report VLPNPV: Sessions 1 and 2: Plenary.

    Science.gov (United States)

    Sainsbury, Frank

    2014-01-01

    Following the highly successful inaugural meeting in 2012, the second installment of Virus-Like Particles and Nano-Particle Vaccines (VLPNPV), proved to be a worthy follow-up in an outstanding conference series. VLPNPV is a forum for academics and industry to address one of the major areas of need in biomedical sciences, the development of novel prophylactic and therapeutic vaccines. The conference was opened by Professor Marianne Manchester of the University of California, San Diego who pointed to the significance of the site chosen for the conference, the Salk Institute. Founded by Jonas Salk, the Salk Institute for Biological Studies is a non-profit, independent research institute with focuses in molecular biology and genetics, neurosciences, and plant biology. This diversity in research themes reflects the wishes of the institute's founder who saw value in using interdisciplinary approaches to understanding the basic principles in life, aimed at generating new therapies and treatments for human disease. Likewise, interdisciplinarity was reflected in the main themes of the meeting, which also highlight some of the potential advantages of virus-like particle (VLP) and nanoparticle vaccines, including novel formulations/adjuvanting effects, structurally accurate/designed antigens, production systems and capacity, and tailoring the immune response. These themes were covered by the 2 plenary sessions that opened the conference and are described in this report.

  8. Achieving an HIV vaccine: the need for an accelerated national campaign.

    Science.gov (United States)

    Marlink, R

    1997-11-01

    The development of an effective HIV vaccine has become a crucial national healthcare goal. To develop a worldwide AIDS vaccine, an international collaboration with developing countries is needed. The global approach rationale is threefold: millions of lives can be saved, a vaccine preparation can be tested more rapidly and economically among populations with high rates of infections; and the HIV epidemic comprises at least ten different subtypes. Although a number of barriers to the successful development of an HIV vaccine exist, the polio vaccine can be used as an example to show researchers how to overcome the obstacles. Jonas Salk, the polio vaccine developer, used killed whole virus in a technique that critics argued would not be fully effective. However, the Salk vaccine reduced polio-related paralysis by 72 percent, while the more effective Sabin oral vaccine did not become available until several years later. The lesson to be learned is that any percent of effectiveness is better than nothing, and researchers should not abandon uncertain HIV vaccine development efforts because they believe a better solution may develop in the future. The existence of traditional research should not preclude the development of new solutions that might prove more effective. For example, in the case of polio, the March of Dimes campaign pushed both the Salk and Sabin vaccines despite the skepticism of many academic research groups.

  9. Rebuilding immunity with Remune.

    Science.gov (United States)

    Whitfield, L

    1998-01-01

    Remune, an immune response therapy composed of inactivated HIV, is designed to enhance the immune system's ability to recognize and kill HIV proteins. Developed by Dr. Jonas Salk, researchers hope Remune's actions can alter the course of HIV infection and slow disease progression. Remune has gained Food and Drug Administration (FDA) approval to enter the critical Phase III trial stage. Two clinical trials are tracking Remune's immunogenicity (ability to provoke an immune response), its immunogenicity relative to dose level, and its effect on viral load. An ongoing trial, approved in February of 1996, enrolled 2,500 patients at 74 sites. The manufacturer, Immune Response Corporation (IRC), announced earlier this year that treatment with Remune induces an immune response to HIV that cross-reacts with different strains of the virus. This immune response is crucial for developing an effective worldwide treatment. Remune decreases levels of tumor necrosis factor alpha (TNF-a). IRC recently began a Phase I clinical trial in Great Britain that combines Remune with a protease inhibitor, two antiviral nucleoside analogues, and Interleukin-2. The trial is designed to determine the role that the drug may play in restoring immune response.

  10. [AIDS: "We will win"].

    Science.gov (United States)

    Chabrier, H

    1989-11-13

    An international colloquium on AIDS held near Paris from October 26-28, 1989, unlike the World Conference on AIDS in Montreal the year before, was able to find reasons for optimism. Significant progress was reported in immunotherapy and in chemotherapy. Successful experiments in vaccinating monkeys against the AIDS virus were reported from the US, France, and Zaire. Time is needed to prove the efficacy of the vaccines because of the slow development in AIDS. A vaccine is being tested by Jonas Salk and collaborators in 75 seropositive volunteers who do not yet show full blown disease but who have very low levels of T4 lymphocytes. Plans are underway for a larger test on 500 seropositive patients at different stages of infection. According to Salk, the new chemical and logical approach toward AIDS will allow combinations of immunotherapy and chemotherapy to destroy the virus. R. Gallo of France listed as accomplishments of the past year a better understanding of the virus, improved case management techniques, increased ability to control Kaposi's sarcoma, considerable progress in the search for a vaccine, and detection of immune proteins that affect the virus. New biological markers permit establishment of correlations between cellular modifications and the progress of the disease as well as the precise effects of treatment. The new immune system drugs immuthiol and DDI are expected to reach the market soon. Patients very soon will be able to receive less toxic alternative treatments, which can be combined for greater efficacy once their toxic interactions are understood.

  11. Vaccines today, vaccines tomorrow: a perspective.

    Science.gov (United States)

    Loucq, Christian

    2013-01-01

    Vaccines are considered as one of the major contributions of the 20th century and one of the most cost effective public health interventions. The International Vaccine Institute has as a mission to discover, develop and deliver new and improved vaccines against infectious diseases that affects developing nations. If Louis Pasteur is known across the globe, vaccinologists like Maurice Hilleman, Jonas Salk and Charles Mérieux are known among experts only despite their contribution to global health. Thanks to a vaccine, smallpox has been eradicated, polio has nearly disappeared, Haemophilus influenzae B, measles and more recently meningitis A are controlled in many countries. While a malaria vaccine is undergoing phase 3, International Vaccine Institute, in collaboration with an Indian manufacturer has brought an oral inactivated cholera vaccine to pre-qualification. The field of vaccinology has undergone major changes thanks to philanthropists such as Bill and Melinda Gates, initiatives like the Decade of Vaccines and public private partnerships. Current researches on vaccines have more challenging targets like the dengue viruses, malaria, human immunodeficiency virus, the respiratory syncytial virus and nosocomial diseases. Exciting research is taking place on new adjuvants, nanoparticles, virus like particles and new route of administration. An overcrowded infant immunization program, anti-vaccine groups, immunizing a growing number of elderlies and delivering vaccines to difficult places are among challenges faced by vaccinologists and global health experts.

  12. HIV-1 Immunogen: an overview of almost 30 years of clinical testing of a candidate therapeutic vaccine.

    Science.gov (United States)

    Graziani, Gina M; Angel, Jonathan B

    2016-07-01

    Although current antiretroviral therapy (ART) has transformed HIV infection into a chronic, manageable disease, ART does not cure HIV infection. Furthermore, the majority of the world's infected individuals live in resource-limited countries in which access to ART is limited. Thus, the development of an effective therapeutic HIV vaccine would be an invaluable treatment alternative. Developed by the late Dr. Jonas Salk, HIV-1 Immunogen (Remune®) is a candidate therapeutic vaccine that has been studied in thousands of HIV-infected individuals in more than a dozen clinical trials during almost three decades. This Drug Evaluation, which summarizes the results of these trials that have shown the vaccine to be safe and immunogenic, also discusses the contradictory and controversial conclusions drawn from the phases 2, 2/3 and 3 trials that assessed the clinical efficacy of this vaccine. Given the lack of unequivocal clinical benefits of HIV-1 Immunogen despite almost 30 years of extensive testing, it does not appear, in our view, that this vaccine is a clinically effective immunotherapy. However, inclusion of this vaccine in the newly proposed 'Kick/Shock and Kill' strategy for HIV eradication, or use as a prophylactic vaccine, could be considered for future trials.

  13. [Piet de Somer, the University of Leuven and the Belgium poliovaccine in 1956-57].

    Science.gov (United States)

    Billiau, A

    2011-01-01

    In the years following WW II, all 'Western' countries were struck by recurrent epidemics of infantile paralysis (poliomyelitis). In the early 1950s, a vaccine developed by Jonas Salk in Pittsburgh, became available in the U.S. and Canada. In 1953-54 central virology laboratories in Sweden, Denmark and France were already well advanced in setting up local production lines of the vaccine. At that point in time, the Catholic University of Leuven, on the initiative of the young microbiology professor, Piet De Somer, and in collaboration with the pharmaceutical concern R.I.T. (Recherches et Industries Thérapeutiques, Genval, Belgium), erected a new, multidisciplinary medical research institute, the Rega Institute. One of the research units to be headed by De Somer was destined to introduce the relatively new discipline of virology. As a test case, De Somer decided to venture on developing a production line of the Salk vaccine. In less than one year's time, the project was successful, such that Belgium became one of the first European countries to be self-supporting for its vaccine supply and to be able to initiate a large-scale vaccination campaign. The planning, preparation and execution of the project was accompanied by an extensive correspondence of De Somer with experts and other concerned parties in Belgium and abroad. This correspondence has been preserved and allows for a detailed reconstruction of the remarkable achievement.

  14. "A different kind of beauty": scientific and architectural style in I.M. Pei's Mesa Laboratory and Louis Kahn's Salk Institute.

    Science.gov (United States)

    Leslie, Stuart W

    2008-01-01

    I.M. Pei's Mesa Laboratory for the National Center for Atmospheric Research in Boulder, Colorado, and Louis Kahn's Salk Institute in La Jolla, California, are rare examples of laboratories as celebrated for their architecture as for their scientific contributions. Completed in the mid-1960s, these signature buildings still express the scientific style of their founding directors, Walter Roberts and Jonas Salk. yet in commissioning their laboratories, Roberts and Salk had to work with architects as strong-willed as themselves. A close reading of the two laboratories reveals the ongoing negotiations and tensions in collaborations between visionary scientist and visionary architect. Moreover, Roberts and Salk also had to become architects of atmospheric and biomedical sciences. For laboratory architecture, however flexible in theory, necessarily stabilizes scientific practice, since a philosophy of research is embedded in the very structure of the building and persists far longer than the initial vision and mission that gave it life. Roberts and Salk's experiences suggest that even the most carefully designed laboratories must successfully adapt to new disciplinary configurations, funding opportunities, and research priorities, or risk becoming mere architectural icons.

  15. Immunology in Pittsburgh.

    Science.gov (United States)

    Finn, Olivera J; Salter, Russell D

    2006-01-01

    The University of Pittsburgh School of Medicine has a long tradition of excellence in immunology research and training. Faculty, students, and postdoctoral fellows walk through hallways that are pictorial reminders of the days when Dr. Jonas Salk worked here to develop the polio vaccine, or when Dr. Niels Jerne chaired the Microbiology Department and worked on perfecting the Jerne Plaque Assay for antibody-producing cells. Colleagues and postdoctoral fellows of Professor Salk are still on the faculty of the University of Pittsburgh Medical School as are graduate students of Professor Jerne. A modern research building, the 17 story high Biomedical Science Tower, is a vivid reminder of the day when Dr. Thomas Starzl arrived in Pittsburgh and started building the most prominent solid-organ-transplant program in the world. The immunology research that developed around the problem of graft rejection and tolerance induction trained numerous outstanding students and fellows. Almost 20 yr ago, the University of Pittsburgh founded the University of Pittsburgh Cancer Institute (UPCI) with the renowned immunologist Dr. Ronald Herberman at its helm. This started a number of new research initiatives in cancer immunology and immunotherapy. A large number of outstanding young investigators, as well as several well-established tumor immunologists, were recruited to Pittsburgh at that time.

  16. O discurso ideológico-nacionalista em cartilha distribuída pelo exército do RS durante o período ditatorial no brasil

    Directory of Open Access Journals (Sweden)

    João Paulo Massoti

    2017-07-01

    Full Text Available Este artigo se propõe a pensar a Ditadura Militar brasileira e a reprodução do seu pensamento ideológico através do estudo do discurso na Carta a um recruta entregue aos jovens em idade para o alistamento militar no ano de 1968 no Estado do Rio Grande do Sul. Escrita pelo Ten. Cel. Jonas Correia Neto e expedida pelo Ministério do Exército sob a supervisão e coordenação da Secretaria de Educação e Cultura - Coordenação de Educação Moral e Cívica do RS, a carta possui uma voz paternal que se propõe a mostrar ao jovem que o melhor caminho a seguir é o da ordem e da obediência. Para pensar ideologia será elaborada uma construção conceitual baseada no estudo das realidades vividas pela sociedade no contexto histórico geral (a ditadura, visando compreender as inúmeras incoerências presentes na carta (discurso militar, a fim de atenuar ou minimizar as arbitrariedades cometidas em nome do Estado. O estudo proposto apresenta aporte teórico a partir da concepção de ideologia de autores como Slavoj Zizek e Sigmun Freud que discorrem sobre o modo inconfesso de servir algum interesse particular de poder.

  17. Quark model calculations of current correlators in the nonperturbative domain

    International Nuclear Information System (INIS)

    Celenza, L.S.; Shakin, C.M.; Sun, W.D.

    1995-01-01

    The authors study the vector-isovector current correlator in this work, making use of a generalized Nambu-Jona-Lasinio (NJL) model. In their work, the original NJL model is extended to describe the coupling of the quark-antiquark states to the two-pion continuum. Further, a model for confinement is introduced that is seen to remove the nonphysical cuts that appear in various amplitudes when the quark and antiquark go on mass shell. Quite satisfactory results are obtained for the correlator. The authors also use the correlator to define a T-matrix for confined quarks and discuss a rho-dominance model for that T-matrix. It is also seen that the Bethe-Salpeter equation that determines the rho mass (in the absence of the coupling to the two-pion continuum) has more satisfactory behavior in the generalized model than in the model without confinement. That improved behavior is here related to the absence of the q bar q cut in the basic quark-loop integral of the generalized model. In this model, it is seen how one may work with both quark and hadron degrees of freedom, with only the hadrons appearing as physical particles. 12 refs., 16 figs., 1 tab

  18. Responsibility: The First Virtue of Innovation? A discussion of some ethical and meta-ethical issues concerning the concept of ‘responsibility’ in technological innovation

    Directory of Open Access Journals (Sweden)

    Espen D. Stabell

    2014-11-01

    Full Text Available In this paper I investigate the concept of responsibility in the context of technological innovation, with reference to two types of responsibility: ex post and ex ante responsibility. Exposing the shortcomings of ex post responsibility in the context of innovation, I examine different ways of conceiving of a form of ex ante responsibility suitable for our current technological situation. Here I identify two positions with very different approaches to the question of the ethical status of responsibility: Hans Jonas’s concept of responsibility as an ethical principle structuring moral behavior, and René von Schomberg’s idea of responsibility as “responsiveness” linked to procedures of communication and collaboration. Rejecting von Schomberg’s concept on ethico-philosophical grounds, I argue in favor of a critical rehabilitation of some basic thoughts in the philosophy of Jonas. Finally, I suggest taking the step from the Jonasian ethics of responsibility towards the Hegelian concept of Sittlichkeit – a concrete social morality that disentangles responsibility from the dilemmas of subjectivist morality.

  19. Environmental Ethics and Responsibility

    Directory of Open Access Journals (Sweden)

    Luiz Paulo Rouanet

    2015-09-01

    Full Text Available http://dx.doi.org/10.5007/1677-2954.2015v14n3p382 This paper resumes a previous discussion on Environmental Ethics and Irreversibility, which was presented in 2005. There I first faced the problem. Now I would like to reevaluate the issue. Was my paper “catastrophist”? Or was it, instead, realistic? Which are today the main issues confronting Environmental Ethics? Plainly speaking, what can we really do? These are some of the questions I would like to bring in to the debate with my colleagues and the public. In other words, instead of focusing in the aspect of “irreversibility”, I prefer here to focus on the “responsibility” of agents and institutions. It rescues the so-called “Principle of Responsibility”, by Hans Jonas. There is also some debate with Karl-Otto Appel and Habermas. If, on one hand, there are irreversible damages to nature, as the extinction of species and even of natural locations, as rivers and other natural accidents, there are, on the other hand, many actions that can and must be taken in order to preserve or deter the grave consequences of the environmental degradation. In this paper, I try to discuss some of the problems and propose some solutions, but the more important thing is to call everyone – individuals, groups, or institutions – to responsibility face the Earth, the Human and not-human beings, and mainly the future generations.

  20. [Inactivated poliovirus vaccines: an inevitable choice for eliminating poliomyelitis].

    Science.gov (United States)

    Vidor, J D; Jean-Denis, Shu

    2016-12-06

    The inactivated poliovirus vaccine (IPV) is a very old tool in the fight against poliomyelitis. Though supplanted by oral poliovirus vaccine (OPV) in the 1960s and 1970s, the IPV has now become an inevitable choice because of the increasingly recognized risks associated with continuous use of OPVs. Following the pioneering work of Jonas Salk, who established key principles for the IPV, considerable experience has accumulated over the years. This work has led to modern Salk IPV-containing vaccines, based on the use of inactivated wildtype polioviruses, which have been deployed for routine use in many countries. Very good protection against paralysis is achieved with IPV through the presence of circulating antibodies able to neutralize virus infectivity toward motor neurons. In addition, with IPV, a variable degree of protection against mucosal infection (and therefore transmission) through mucosal antibodies and immune cells is achieved, depending on previous exposure of subjects to wildtype or vaccine polioviruses. The use of an IPV-followed-by-OPV sequential immunization schedule has the potential advantage of eliminating the vaccine-associated paralytic poliomyelitis (VAPP) risk, while limiting the risks of vaccine-derived poliovirus (VDPVs). Sabin strain-derived IPVs are new tools, only recently beginning to be deployed, and data are being generated to document their performance. IPVs will play an irreplaceable role in global eradication of polio.

  1. Large N dynamics in QED in a magnetic field

    International Nuclear Information System (INIS)

    Gusynin, V.P.; Miransky, V.A.; Shovkovy, I.A.

    2003-01-01

    The expression for the dynamical mass of fermions in QED in a magnetic field is obtained for a large number of the fermion flavor N in the framework of 1/N expansion. The existence of a threshold value N thr , dividing the theories with essentially different dynamics, is established. For the number of flavors N thr , the dynamical mass is very sensitive to the value of the coupling constant α b , related to the magnetic scale μ=√(vertical bar eB vertical bar). For N of the order of N thr or larger, a dynamics similar to that in the Nambu-Jona-Lasinio model with a cutoff of the order of √(vertical bar eB vertical bar) and the dimensional coupling constant G∼1/(N vertical bar eB vertical bar) takes place. In this case, the value of the dynamical mass is essentially α b independent (the dynamics with an infrared stable fixed point). The value of N thr separates a weak coupling dynamics (with α-tilde b ≡Nα b b > or approx. 1) and is of the order of 1/α b

  2. Goldstone bosons in a crystalline chiral phase

    International Nuclear Information System (INIS)

    Schramm, Marco

    2017-01-01

    The phase diagram of strong interaction matter is expected to exhibit a rich structure. Different models have shown, that crystalline phases with a spatially varying chiral condensate can occur in the regime of low temperatures and moderate densities, where they replace the first-order phase transition found for spatially constant order parameters. We investigate this inhomogeneous phase, where in addition to the chiral symmetry, translational and rotational symmetry are broken as well, in a two flavor Nambu--Jona-Lasinio model. The main goal of this work is to describe the Goldstone bosons in this phase, massless excitations that occur for spontaneously broken symmetries. We take one of the simplest possible modulations, the chiral density wave, and show how to derive the quark propagator of the theory analytically, by means of transformations in chiral and momentum space. We apply this to a test case for the gap equation. We show the derivation of Nambu-Goldstone modes in the inhomogeneous phase and find, that for our case only three different modes have to be taken into account. We proceed to calculate the Goldstone boson related to the breaking of spatial symmetry, which can be related to the neutral pion. By evaluating a Bethe-Salpeter equation, we can show, that we have indeed found a Goldstone boson and give its dispersion relation in terms of momenta perpendicular, as well as parallel to the mass modulation.

  3. Loop corrections and other many-body effects in relativistic field theories

    International Nuclear Information System (INIS)

    Ainsworth, T.L.; Brown, G.E.; Prakash, M.; Weise, W.

    1988-01-01

    Incorporation of effective masses into negative energy states (nucleon loop corrections) gives rise to repulsive many-body forces, as has been known for some time. Rather than renormalizing away the three- and four-body terms, we introduce medium corrections into the effective σ-exchange, which roughly cancel the nucleon loop terms for densities ρ ≅ ρ nm , where ρ nm is nuclear matter density. Going to higher densities, the repulsive contributions tend to saturate whereas the attractive ones keep on growing in magnitude. The latter is achieved through use of a density-dependent effective mass for the σ-particle, m σ = m σ (ρ), such that m σ (ρ) decreases with increasing density. Such a behavior is seen e.g. in the Nambu-Jona-Lasinio model. It is argued that a smooth transition to chiral restoration implies a similar behavior. The resulting nuclear equation of state is, because of the self-consistency in the problem, immensely insensitive to changes in the mass or coupling constant of the σ-particle. (orig.)

  4. Low-energy QCD and ultraviolet renormalons

    International Nuclear Information System (INIS)

    Peris, S.

    1997-01-01

    We discuss the contribution of ultraviolet (UV) renormalons in QCD to two-point functions of quark current operators. This explicitly includes effects due to the exchange of one renormalon chain as well as two chains. It is shown that, when the external Euclidean momentum of the two-point functions becomes smaller than the scale Λ L associated with the Landau singularity of the QCD one-loop running coupling constant, the positions of the UV renormalons in the Borel plane become true singularities in the integration range of the Borel transform. This introduces ambiguities in the evaluation of the corresponding two-point functions. The ambiguities associated with the leading UV renormalon singularity are of the same type as the contribution due to the inclusion of dimension d=6 local operators in a low-energy effective Lagrangian valid at scales smaller than Λ L . We then discuss the inclusion of an infinite number of renormalon chains and argue that the previous ambiguity hints at a plausible approximation scheme for low-energy QCD, resulting in an effective Lagrangian similar to the one of the extended Nambu-Jona-Lasinio (ENJL) model of QCD at large N c . (orig.)

  5. The deconfinement phase transition, hadronization and the NJL model

    International Nuclear Information System (INIS)

    Raha, Sibaji

    2000-01-01

    One of the confident predictions of QCD is that at sufficiently high temperature and/or density, hadronic matter should undergo a thermodynamic phase transition to a color deconfined state of matter-popularly called the Quark-Gluon Plasma (QGP). In low energy effective theories of Quantum Chromodynamics (QCD), one usually talks of the chiral transition for which a well defined order parameter exists. We investigate the dissociation of pions and kaons in a medium of hot quark matter described by the Nambu-Jona Lasinio (NJL) model. The decay widths of pion and kaon are found to be large but finite at temperature much higher than the critical temperature for the chiral (or deconfinement) transition, the kaon decay width being much larger. Thus pions and even kaons (with a lower density compared to pions) may coexist with quarks and gluons at such high temperatures. On the basis of such premises, we investigate the process of hadronization in quark-gluon plasma with special emphasis on whether such processes shed any light on acceptable low energy effective theories of QCD

  6. Underground urbanity: from the carrefour à étages multiples to the ‘inner street’

    Directory of Open Access Journals (Sweden)

    Alvaro Clua

    2017-04-01

    Full Text Available As Manuel de Solà-Morales noted, urbanity relies on the variety and quality of relations between things, materials and human beings. Considered as such, how are we to achieve an underground urbanity? This paper seeks to address this question through a focussed reading of a number of European urban projects from the 20th century; all of which put special care into ensuring the quality of their subterranean passageways. We begin with the carrefour à giration, which was designed by Eugène Hénard in 1906, in order to identify four fundamental attributes of this kind of urbanity: legibility, spatiality, accessibility and activity. We then continue with a qualitative analysis of the 1933 Blå Bodarna passageway designed by Tage William-Olsson and Holger Blom in Slussen (Stockholm. Looking ahead some decades later, the sequence of passages under the Vienna Ring, built during the mayoralty of Franz J. Jonas, provides a good example of how fundamental the connectivity to the underground public transport system was to the success of these spaces. Finally, the article closes with a review of those underground places found in Santiago Calatrava’s Stadelhofen Station and the Stationsplein by Manuel de Solà-Morales: from the carrefour à étages multiples to the ‘inner street’.

  7. New gadiform fishes (Teleostei, Gadiformes) from the Miocene of Algeria

    Science.gov (United States)

    Carnevale, Giorgio

    2007-02-01

    As part of the completion of studies on the Miocene fishes of the Chelif Basin (north-western Algeria), this paper represents a contribution to the knowledge of the Messinian gadiform diversity of this western Mediterranean, semi-enclosed, Neogene basin. A new genus and species of the family Macrouridae is erected ( Razelainia paradoxa n. gen. et sp.), two specimens are tentatively referred to already existing taxa ( Gadiculus cf. jonas; Merluccius cf. merluccius), and a species formerly assigned to the gadid genus Brosme is transferred to the genus Gaidropsarus ( Gaidropsarus murdjadjensis). The macrourid Razelainia paradoxa n. gen. et sp. is characterized by an unusual combination of: plesiomorphic gadiform features, such as low vertebral number (presumed), well-developed caudal-fin rays, presence of a single continuous dorsal fin originating just posterior to the neurocranium, anal-fin rays slightly longer than dorsal-fin rays; and derived, typically macrourid features, such as the presence of spinoid scales and the anterior anal-fin pterygiophores extending forward over the abdominal wall. A paleoecological analysis reveals that the Messinian gadiform assemblage of the Chelif Basin had a subtropical/warm temperate affinity, with a marked north-eastern Atlantic-Mediterranean biogeographic character.

  8. Prospective Technology Assessment of Synthetic Biology: Fundamental and Propaedeutic Reflections in Order to Enable an Early Assessment.

    Science.gov (United States)

    Schmidt, Jan Cornelius

    2016-08-01

    Synthetic biology is regarded as one of the key technosciences of the future. The goal of this paper is to present some fundamental considerations to enable procedures of a technology assessment (TA) of synthetic biology. To accomplish such an early "upstream" assessment of a not yet fully developed technology, a special type of TA will be considered: Prospective TA (ProTA). At the center of ProTA are the analysis and the framing of "synthetic biology," including a characterization and assessment of the technological core. The thesis is that if there is any differentia specifica giving substance to the umbrella term "synthetic biology," it is the idea of harnessing self-organization for engineering purposes. To underline that we are likely experiencing an epochal break in the ontology of technoscientific systems, this new type of technology is called "late-modern technology." -I start this paper by analyzing the three most common visions of synthetic biology. Then I argue that one particular vision deserves more attention because it underlies the others: the vision of self-organization. I discuss the inherent limits of this new type of late-modern technology in the attempt to control and monitor possible risk issues. I refer to Hans Jonas' ethics and his early anticipation of the risks of a novel type of technology. I end by drawing conclusions for the approach of ProTA towards an early societal shaping of synthetic biology.

  9. The ρππ form factor in the decays ω, φ → 3π and η,KL → π+ π- γ

    International Nuclear Information System (INIS)

    Volkov, M.K.; Osipov, A.A.

    1992-01-01

    The processes ω → 3π, φ → 3π, η → π + π - γ, and K L → π + π - γ have been studied for a long time and from various points of view both in theoretical and in experimental elementary-particle physics. However, appreciable changes have occurred recently in the experimental data on the decays ω → 3π and η → π + π - . The width of the first decay has decreased by 20%, and that of the second has increased by 40%. In this work, taking account of the new data, the authors give a self-consistent description of these processes within the framework of the quark model of superconducting type (QMST) proposed by them. This model is a variety of the well-known Nambu-Jona-Lasinio quark model. They shall take into account all the main effects which have an appreciable influence on the final results. The important role played by the nondiagonal π-α 1 transitions on external lines of quark box diagrams and by the form factor of the ρππ vertex in pole diagrams is shown

  10. Impact of Role Clarity and Strategic Fit on Average Project Success: Moderating Role of Market Turbulence on Telecom Companies of Pakistan

    Directory of Open Access Journals (Sweden)

    Najam UL MABOOD

    2017-06-01

    Full Text Available Advancement in technology has reshaped the businesses across the globe forcing companies to perform tasks and activities in the form of projects. Stakeholder behavior, stakeholder management, strategic fit, role and task clarity are some of the factors that redesign the project success. The current study examine the impact of strategic fit and role clarity on the Average project success and further it enlightens the moderating role of Market turbulence on the relationship between the aforementioned independent and dependent variables. The population of the study comprises of telecom sector of Pakistan. The Data was collected from 201 project team members working on diverse project in Telecom companies of Rawalpindi and Islamabad. The Data was gathered through a questionnaires measured on Likert scale adopted from the study of Beringer, Jonas & Kock (2013. Each Questionnaire comprises of 3 items to measure each variable. SPSS 20.0 Version was used to analyze the data by applying Pearson correlation and multiple regression analysis technique. Findings depicted that role clarity and strategic fit contributed significantly in enhancing success of a project. Results further evidenced that market turbulence negatively moderated the relationship of independent variables on Average project success. The study at the end highlights recommendations for the future researchers.

  11. Inhomogeneity driven by Higgs instability in a gapless superconductor

    International Nuclear Information System (INIS)

    Giannakis, Ioannis; Hou Defu; Huang Mei; Ren Haicang

    2007-01-01

    The fluctuations of the Higgs and pseudo Nambu-Goldstone fields in the 2-flavor color superconductivity (2SC) phase with mismatched pairing are described in the nonlinear realization framework of the gauged Nambu-Jona-Lasinio model. In the gapless 2SC phase, not only Nambu-Goldstone currents can be spontaneously generated, but also the Higgs field exhibits instablity. The Nambu-Goldstone currents generation indicates the formation of the single plane wave Larkin-Ovchinnikov-Fulde-Ferrel state and breaks rotation symmetry, while the Higgs instability favors spatial inhomogeneity and breaks translation invariance. In this paper, we focus on the Higgs instability which has not drawn much attention yet. The Higgs instability cannot be removed without a long range force, thus it persists in the gapless superfluidity and induces phase separation. In the case of gapless 2-flavor color superconductivity state, the Higgs instability can only be partially removed by the electric Coulomb energy. However, it is not excluded that the Higgs instability might be completely removed in the charge neutral gapless color-flavor locked phase by the color Coulomb energy

  12. A self-consistent mean-field approach to the dynamical symmetry breaking

    International Nuclear Information System (INIS)

    Kunihiro, Teiji; Hatsuda, Tetsuo.

    1984-01-01

    The dynamical symmetry breaking phenomena in the Nambu and Jona-Lasimio model are reexamined in the framework of a self-consistent mean-field (SCMF) theory. First, we formulate the SCMF theory in a lucid manner based on a successful decomposition of the Lagrangian into semiclassical and residual interaction parts by imposing a condition that ''the dangerous term'' in Bogoliubov's sense should vanish. Then, we show that the difference of the energy density between the super and normal phases, the correct expression of which the original authors failed to give, can be readily obtained by applying the SCMF theory. Futhermore, it is shown that the expression thus obtained is identical to that of the effective potential (E.P.) given by the path-integral method with an auxiliary field up to the one loop order in the loop expansion, then one finds a new and simple way to get the E.P. Some numerical results of the E.P. and the dynamically generated mass of fermion are also shown. As another demonstration of the powerfulness of the SCMF theory, we derive, in the Appendix, the energy density of the O(N)-phi 4 model including the higher order corrections in the sense of large N expansion. (author)

  13. Phases of QCD

    Energy Technology Data Exchange (ETDEWEB)

    Roessner, Simon

    2009-04-09

    Quantum Chromodynamics (QCD) is the theory of the strong interaction within the Standard Model of elementary particles. Today's research in this area dedicates substantial resources to numeric solutions of the QCD field equations and experimental programs exploring the phases of QCD. This thesis proceeds along a complementary line - that of modelling QCD, with the aim of identifying its dominant degrees of freedom. This is possible by minimally coupling effective potentials for the Polyakov loop to Nambu-Jona-Lasinio models using temporal background fields to model chiral symmetry breaking respecting colour confinement. The fermion sign problem resulting from the minimal coupling is addressed in this work establishing a novel, systematically ordered approach. The modifications to the approximative order parameter of colour confinement, the Polyakov loop, are in direct connection with the fermion sign problem. Furthermore an effective coupling of quark densities of different flavours is induced. This mechanism, most likely also present in QCD, produces finite contributions to flavour off diagonal susceptibilities. Susceptibilities are amongst the most promising physical quantities for the experimental exploration of the phase transition at high temperatures and densities. (orig.)

  14. Normal ground state of dense relativistic matter in a magnetic field

    International Nuclear Information System (INIS)

    Gorbar, E. V.; Miransky, V. A.; Shovkovy, I. A.

    2011-01-01

    The properties of the ground state of relativistic matter in a magnetic field are examined within the framework of a Nambu-Jona-Lasinio model. The main emphasis of this study is the normal ground state, which is realized at sufficiently high temperatures and/or sufficiently large chemical potentials. In contrast to the vacuum state, which is characterized by the magnetic catalysis of chiral symmetry breaking, the normal state is accompanied by the dynamical generation of the chiral shift parameter Δ. In the chiral limit, the value of Δ determines a relative shift of the longitudinal momenta (along the direction of the magnetic field) in the dispersion relations of opposite chirality fermions. We argue that the chirality remains a good approximate quantum number even for massive fermions in the vicinity of the Fermi surface and, therefore, the chiral shift is expected to play an important role in many types of cold dense relativistic matter, relevant for applications in compact stars. The qualitative implications of the revealed structure of the normal ground state on the physics of protoneutron stars are discussed. A noticeable feature of the Δ parameter is that it is insensitive to temperature when T 0 , where μ 0 is the chemical potential, and increases with temperature for T>μ 0 . The latter implies that the chiral shift parameter is also generated in the regime relevant for heavy ion collisions.

  15. Chiral and color-superconducting phase transitions with vector interaction in a simple model

    International Nuclear Information System (INIS)

    Kitazawa, Masakiyo; Koide, Tomoi; Kunihiro, Teiji; Nemoto, Yukio

    2002-01-01

    We investigate effects of the vector interaction on chiral and color superconducting (CSC) phase transitions at finite density and temperature in a simple Nambu-Jona-Lasinio model. It is shown that the repulsive density-density interaction coming from the vector term, which is present in the effective chiral models but has been omitted, enhances the competition between the chiral symmetry breaking (χSB) and CSC phase transition, and thereby makes the thermodynamic potential have a shallow minimum over a wide range of values of the correlated chiral and CSC order parameters. We find that when the vector coupling is increased, the first order transition between the χSB and CSC phases becomes weaker, and the coexisting phase in which both the chiral and color-gauge symmetry are dynamically broken comes to exist over a wider range of the density and temperature. We also show that there can exist two endpoints, which are tricritical points in the chiral limit, along the critical line of the first order transition in some range of values of the vector coupling. Although our analysis is based on a simple model, the nontrivial interplay between the χSB and CSC phases induced by the vector interaction is expected to be a universal phenomenon and might give a clue to understanding results obtained with two-color QCD on the lattice. (author)

  16. Light-front realization of chiral symmetry breaking

    International Nuclear Information System (INIS)

    Itakura, Kazunori; Maedan, Shinji

    2001-01-01

    We discuss a description of chiral symmetry breaking in the light-front (LF) formalism. Based on careful analyses of several modes, we give clear answers to the following three fundamental questions: (i) What is the difference between the LF chiral transformation and the ordinary chiral transformation? (ii) How does a gap equation for the chiral condensate emerge? (iii) What is the consequence of the coexistence of a nonzero chiral condensate and the trivial Fock vacuum? The answer to Question (i) is given through a classical analysis of each model. Question (ii) is answered based on our recognition of the importance of characteristic constraints, such as the zero-mode and fermionic constraints. Question (iii) is intimately related to another important problem, reconciliation of the nonzero chiral condensate ≠ 0 and the invariance of the vacuum under the LF chiral transformation Q 5 LF | 0> = 0. This and Question (iii) are understood in terms of the modified chiral transformation laws of the dependent variables. The characteristic ways in which the chiral symmetry breaking is realized are that the chiral charge Q 5 LF is no longer conserved and that the transformation of the scalar and pseudoscalar fields is modified. We also discuss other outcomes, such as the light-cone wave function of the pseudoscalar meson in the Nambu-Jona-Lasinio model. (author)

  17. Anatomy of the magnetic catalysis by renormalization-group method

    Science.gov (United States)

    Hattori, Koichi; Itakura, Kazunori; Ozaki, Sho

    2017-12-01

    We first examine the scaling argument for a renormalization-group (RG) analysis applied to a system subject to the dimensional reduction in strong magnetic fields, and discuss the fact that a four-Fermi operator of the low-energy excitations is marginal irrespective of the strength of the coupling constant in underlying theories. We then construct a scale-dependent effective four-Fermi interaction as a result of screened photon exchanges at weak coupling, and establish the RG method appropriately including the screening effect, in which the RG evolution from ultraviolet to infrared scales is separated into two stages by the screening-mass scale. Based on a precise agreement between the dynamical mass gaps obtained from the solutions of the RG and Schwinger-Dyson equations, we discuss an equivalence between these two approaches. Focusing on QED and Nambu-Jona-Lasinio model, we clarify how the properties of the interactions manifest themselves in the mass gap, and point out an importance of respecting the intrinsic energy-scale dependences in underlying theories for the determination of the mass gap. These studies are expected to be useful for a diagnosis of the magnetic catalysis in QCD.

  18. Nuclear matter descriptions including quark structure of the hadrons

    International Nuclear Information System (INIS)

    Huguet, R.

    2008-07-01

    It is nowadays well established that nucleons are composite objects made of quarks and gluons, whose interactions are described by Quantum chromodynamics (QCD). However, because of the non-perturbative character of QCD at the energies of nuclear physics, a description of atomic nuclei starting from quarks and gluons is still not available. A possible alternative is to construct effective field theories based on hadronic degrees of freedom, in which the interaction is constrained by QCD. In this framework, we have constructed descriptions of infinite nuclear matter in relativistic mean field theories taking into account the quark structure of hadrons. In a first approach, the in medium modifications of mesons properties is dynamically obtained in a Nambu-Jona-Lasinio (NJL) quark model. This modification is taken into account in a relativistic mean field theory based on a meson exchange interaction between nucleons. The in-medium modification of mesons masses and the properties of infinite nuclear matter have been studied. In a second approach, the long and short range contributions to the in-medium modification of the nucleon are determined. The short range part is obtained in a NJL quark model of the nucleon. The long range part, related to pions exchanges between nucleons, has been determined in the framework of Chiral Perturbation theory. These modifications have been used to constrain the couplings of a point coupling relativistic mean field model. A realistic description of the saturation properties of nuclear matter is obtained. (author)

  19. The bag model and the Nambu-Goldstone pion

    International Nuclear Information System (INIS)

    Lee, H.C.; Ho-Kim, Q.

    1983-01-01

    The MIT bag model for the pion is improved and extended in such a way that the pion does not have spurious center-of-mass motions; perturbative gluon contributions to the pion mass msub(π) and decay constant fsub(π) are both calculated to lowest order in αsub(s). The pion is a Nambu-Goldstone boson in the sense that the vacuum in the bag refers to massive constituent quarks, but not so massless current quarks. The transformation of Nambu and Jona-Lasinio between massive and massless quarks is utilized in the computation of fsub(π), the result of which strongly suggests that quarks in the pion are correlated, characterized by a correlation momentum which is proportional 300 MeV/c. The vacuum expectation value for the massless quark condensate is calculated to be proportional0.04 GeV 3 , corresponding to a current quark mass of proportional4 MeV. The requirement that msub(π) approaches zero in a manner consistent with PCAC constrains the bag energy to be msub(π)/4. (orig.)

  20. Hadronization of quark-diquark model for nucleon structure and nuclear force by path integral

    International Nuclear Information System (INIS)

    Nagata, Keitaro

    2003-01-01

    One of the central issues of the hadron physics is how to interpret the properties and the origin of nuclear force. Nuclear force is in principle the manifestation of dynamics of quarks and gluons but no trial has been successful yet in describing the nuclear force by using QCD, the fundamental theory of the strong interactions. Phenomenon related to the chiral symmetry and the spontaneous breaking of the chiral symmetry is one of the important phenomena for the understanding of hadron physics. Nambu-Jona-Lasinio (NJL) model is one of the quark system models to explain the phenomena concerning the chiral symmetry. Although the method to deduce the Lagrangian describing mesons by applying the path integral to NJL model has been well known as the bosonization, it has been difficult to extend it to baryons because baryons are three-body system. In this paper, a method is reported to deduce Lagrangian which describes baryon-meson from quark-diquark Lagrangian by assuming that baryons are the bound states of quark and diquark. (S. Funahashi)

  1. Inhomogeneous chiral symmetry breaking in isospin-asymmetric strong-interaction matter

    Energy Technology Data Exchange (ETDEWEB)

    Nowakowski, Daniel

    2017-07-01

    In this thesis we investigate the effects of an isospin asymmetry on inhomogeneous chiral symmetry breaking phases, which are characterized by spatially modulated quarkantiquark condensates. In order to determine the relevance of such phases for the phase diagram of strong-interaction matter, a two-flavor Nambu-Jona-Lasinio model is used to study the properties of the ground state of the system. Confirming the presence of inhomogeneous chiral symmetry breaking in isospin-asymmetric matter for a simple Chiral Density Wave, we generalize the modulation of the quark-antiquark pairs to more complicated shapes and study the effects of different degrees of flavor-mixing on the inhomogeneous phase at non-zero isospin asymmetry. Then, we investigate the occurrence of crystalline chiral symmetry breaking phases in charge-neutral matter, from which we determine the influence of crystalline phases on a quark star by calculating mass-radius sequences. Finally, our model is extended through color-superconducting phases and we study the interplay of these phases with inhomogeneous chiral-symmetry breaking at non-vanishing isospin asymmetry, before we discuss our findings.

  2. [Sigmund Freud and the "Zeitschrift für Hypnotismus"].

    Science.gov (United States)

    Tanner, Terence A

    2005-01-01

    While Freud was always ready to acknowledge the debt that psychoanalysis owed to hypnotism, his engagement in its study and medical application is often seen by historians as little more than a passing phase on the way to psychoanalysis proper. This paper attempts to redress the balance by exploring Freud's association with the most influential German-language journal devoted to hypnotism, the Zeitschrift für Hypnotismus. Freud not only contributed a paper to this periodical but also served on its editorial board for the first three years of its existence. There also appeared in the journal one review and six abstracts of his work. After a condensed bibliographical account of the journal, a summary is given of Freud's intellectual and professional contacts and exchanges with three of the key individuals associated with it: August Forel, Jonas Grossmann and Oskar Vogt. Finally clarification is given of the publication history of the "Dora" case history and the chronology of its rejection for publication by Korbinian Brodmann, editor of the journal when it became the Journal für Psychologie und Neurologie.

  3. Memorial volume for Y. Nambu

    CERN Document Server

    Chang, Lay Nam; Han, Moo-Young; Phua, Kok Khoo

    2016-01-01

    We have lost one of the giants of the twentieth century physics when Yoichiro Nambu passed away in July, 2015, at the age of 94. Today's Standard Model, though still incomplete in many respects, is the culmination of the most successful theory of the Universe to date, and it is built upon foundations provided by discoveries made by Nambu in the 1960s: the mechanism of spontaneously broken symmetry in Nature (with G Jona-Lasinio) and the hidden new SU(3) symmetry of quarks and gluons (with M-Y Han). In this volume honoring Nambu's memory, World Scientific Publishing presents a unique collection of papers written by his former colleagues, collaborating researchers and former students and associates, not only citing Nambu's great contributions in physics but also many personal and private reminiscences, some never told before. This volume also contains the very last scientific writing by Professor Nambu himself, discussing the development of particle physics. This book is a volume for all who benefited not on...

  4. Constitutive modeling of polycarbonate over a wide range of strain rates and temperatures

    Science.gov (United States)

    Wang, Haitao; Zhou, Huamin; Huang, Zhigao; Zhang, Yun; Zhao, Xiaoxuan

    2017-02-01

    The mechanical behavior of polycarbonate was experimentally investigated over a wide range of strain rates (10^{-4} to 5× 103 s^{-1}) and temperatures (293 to 353 K). Compression tests under these conditions were performed using a SHIMADZU universal testing machine and a split Hopkinson pressure bar. Falling weight impact testing was carried out on an Instron Dynatup 9200 drop tower system. The rate- and temperature-dependent deformation behavior of polycarbonate was discussed in detail. Dynamic mechanical analysis (DMA) tests were utilized to observe the glass (α ) transition and the secondary (β ) transition of polycarbonate. The DMA results indicate that the α and β transitions have a dramatic influence on the mechanical behavior of polycarbonate. The decompose/shift/reconstruct (DSR) method was utilized to decompose the storage modulus into the α and β components and extrapolate the entire modulus, the α-component modulus and the β-component modulus. Based on three previous models, namely, Mulliken-Boyce, G'Sell-Jonas and DSGZ, an adiabatic model is proposed to predict the mechanical behavior of polycarbonate. The model considers the contributions of both the α and β transitions to the mechanical behavior, and it has been implemented in ABAQUS/Explicit through a user material subroutine VUMAT. The model predictions are proven to essentially coincide with the experimental results during compression testing and falling weight impact testing.

  5. A royal visit

    CERN Multimedia

    2006-01-01

    King Harald V and Queen Sonja of Norway made a trip to CERN on Tuesday 4 April, taking a tour of part of the LHC and greeting the Norwegian students and scientists at the Laboratory. Norway's King Harald V and Queen Sonja take a tour of the ATLAS detector with CERN Director-General Robert Aymar.King Harald V and Queen Sonja are greeted warmly by members of the Norwegian community at the CERN Globe. CERN Director-General Robert Aymar welcomed the royal party, which included the Norwegian Minister of Foreign Affairs, Jonas Gahr Støre, and provided an overview of CERN's history and current and future research. ATLAS deputy spokesperson Steinar Stapnes then quickly explained the concept and inner workings of the LHC, some LHC physics goals and ATLAS, which is one of the main experiments receiving Norwegian contributions. 'I don't think I've ever had so many distinguished students before,' Stapnes said jokingly to the crowd.The royal delegation was then escorted underground for a look at the LHC tunnel and the...

  6. Phases of QCD

    International Nuclear Information System (INIS)

    Roessner, Simon

    2009-01-01

    Quantum Chromodynamics (QCD) is the theory of the strong interaction within the Standard Model of elementary particles. Today's research in this area dedicates substantial resources to numeric solutions of the QCD field equations and experimental programs exploring the phases of QCD. This thesis proceeds along a complementary line - that of modelling QCD, with the aim of identifying its dominant degrees of freedom. This is possible by minimally coupling effective potentials for the Polyakov loop to Nambu-Jona-Lasinio models using temporal background fields to model chiral symmetry breaking respecting colour confinement. The fermion sign problem resulting from the minimal coupling is addressed in this work establishing a novel, systematically ordered approach. The modifications to the approximative order parameter of colour confinement, the Polyakov loop, are in direct connection with the fermion sign problem. Furthermore an effective coupling of quark densities of different flavours is induced. This mechanism, most likely also present in QCD, produces finite contributions to flavour off diagonal susceptibilities. Susceptibilities are amongst the most promising physical quantities for the experimental exploration of the phase transition at high temperatures and densities. (orig.)

  7. Microstructural modelling and lubrication study during zirconium alloy hot extrusion

    International Nuclear Information System (INIS)

    Gaudout, B.

    2009-01-01

    Using torsion tests (with strain rate jumps) and an experimental hot mini-extrusion apparatus, several samples zirconium alloy have been deformed: Zircaloy-4 (high α range) and Zr-1Nb (α + β domain). The fragmentation of the microstructure and post-dynamic grain growth have been examined. The main difference between these two alloys is that Zr-1Nb does not show grain growth during a heat treatment within the α + β domain after hot deformation. The recrystallization volume fraction has been measured on extruded samples with or without heat treatment. These rheological and microstructural data have been used to determine the parameters of a microstructural model including: a work-hardening model (Laaasraoui/Jonas), a continuous dynamic recrystallization model (Gourdet/Montheillet) and a grain growth model. This model leads to a good prediction of recrystallization volume fraction for Zircaloy-4 extrusion. However, the Zr-1Nb model cannot be validated because of the difficulty to observe deformed microstructures. Extrusion process is lubricated with a solid film. Trapping tests show that this lubricant is thermoviscoplastic. Friction along the container and several observations show the lubrication is not realized by a continuous film. Indeed, the heterogeneousness of deformation of these alloys causes a rupture of the lubricant film. Experiments and numerical simulations show that the radial gradient of axial displacement is affected by friction but also by stress softening of the alloys. (author)

  8. Interacting fermions in rotation: chiral symmetry restoration, moment of inertia and thermodynamics

    International Nuclear Information System (INIS)

    Chernodub, M.N.; Gongyo, Shinya

    2017-01-01

    We study rotating fermionic matter at finite temperature in the framework of the Nambu-Jona-Lasinio model. In order to respect causality the rigidly rotating system must be bound by a cylindrical boundary with appropriate boundary conditions that confine the fermions inside the cylinder. We show the finite geometry with the MIT boundary conditions affects strongly the phase structure of the model leading to three distinct regions characterized by explicitly broken (gapped), partially restored (nearly gapless) and spontaneously broken (gapped) phases at, respectively, small, moderate and large radius of the cylinder. The presence of the boundary leads to specific steplike irregularities of the chiral condensate as functions of coupling constant, temperature and angular frequency. These steplike features have the same nature as the Shubnikov-de Haas oscillations with the crucial difference that they occur in the absence of both external magnetic field and Fermi surface. At finite temperature the rotation leads to restoration of spontaneously broken chiral symmetry while the vacuum at zero temperature is insensitive to rotation (“cold vacuum cannot rotate”). As the temperature increases the critical angular frequency decreases and the transition becomes softer. A phase diagram in angular frequency-temperature plane is presented. We also show that at fixed temperature the fermion matter in the chirally restored (gapless) phase has a higher moment of inertia compared to the one in the chirally broken (gapped) phase.

  9. Strong U{sub A}(1) breaking in radiative {eta} decays

    Energy Technology Data Exchange (ETDEWEB)

    Takizawa, M.; Nemoto, Y.; Oka, M.

    1996-08-01

    We study the {eta} {yields} {gamma}{gamma}, {eta} {yields} {gamma}{mu}{sup -}{mu}{sup +} and {eta} {yields} {pi}{sup 0}{gamma}{gamma} decays using an extended three-flavor Nambu-Jona-Lasinio model that includes the `t Hooft instanton induced interaction. We find that the {eta}-meson mass, the {eta} {yields} {gamma}{gamma}, {eta} {yields} {gamma}{mu}{sup -}{mu}{sup +} and {eta} {yields} {pi}{sup 0}{gamma}{gamma} decay widths are in good agreement with the experimental values when the U{sub A}(1) breaking is strong and the flavor SU(3) singlet-octet mixing angle {theta} is about zero. The calculated {eta}{gamma}{gamma}{sup *} transition form factor has somewhat weaker dependence on the squared four-momentum of the virtual photon. The effects of the U{sub A}(1) anomaly on the scalar quark contents in the nucleon, the {Sigma}{sub {pi}N} and {Sigma}{sub KN} terms and the baryon number one and two systems are also studied. (author)

  10. [Brain death and organ transplantation: ethical dilemmas for nursing?].

    Science.gov (United States)

    Windels-Buhr, D

    1997-06-01

    According to the WHO Program, nurses should be active in public health care as equal members of a multiprofessional team. This position requires competent professional action, which also implies moral competence, especially necessitated by the coming paradigmatic changes caused by shifts in the previous and current boundaries of the paradigm human being. One reason for this shift are the greater medical technical possibilities. The medical definition of brain death as the death of a human being per se is one example of the altered boundary and its consequences. Must future components of the nursing metaparadigm be changed because of this? To what extent is nursing ethically obligated to integrate changes in social values into its metaparadigm, ethics and objectives? The nursing metaparadigm, Henderson's definition of nursing, the ICN's Basic Code of Ethics, and the nursing model according to Roper, Logan & Tierney were used as the basis in the analysis of the subject matter and problems. Furthermore, philosophical viewpoints of Jonas & Harris will be included to clarify the deontological and teleological aspects of standard ethics. Finally, conclusions are drawn about the intra- and interprofessional ethical discourse about brain death and organ transplantation among nursing professionals.

  11. For information: Geneva University

    CERN Multimedia

    2006-01-01

    Ecole de physiqueDépartement de physique nucléaire et corspusculaire 24, Quai Ernest-Ansermet 1211 GENEVE 4TéL: (022) 379 62 73 Fax: (022) 379 69 92 Lundi 16 janvier COLLOQUE DE LA SECTION DE PHYSIQUE 17h00 - Auditoire Stückelberg Recent progress in understanding irreversible processes Professeur G. Jona-Lasino / Institute: Université de Rome 'La Sapienza' For over seventy years our understanding of irreversible processes has been based on Onsager's 1931 papers which have provided the tools to analyse experiments in physics and physical chemistry. Onsager's approach however is valid only near equilibrium. In particular it does not require the definition of non equilibrium thermodynamic functionals. Recently progress has been achieved via an extension of Einstein's theory of thermodynamic fluctuations to non equilibrium dynamical situations without the restriction of being close to equilibrium. We shall illustrate some of the basic ideas and results. Information: http://theory.physics.unige.ch/~...

  12. Top and Higgs masses in a composite boson model

    International Nuclear Information System (INIS)

    Kahana, D.E.

    1993-01-01

    Recently Nambu as well as Bardeen, Hill and Linden have suggested replacing the Higgs mechanism with a dynamical symmetry breaking generated by four fermion interactions of the top quark. In fact the model for replacing the scalar sector is that of Nambu and Jona-Lasinio (NJL) and one recovers the Higgs as a tt composite. Earlier authors have also treated vector mesons as composites within the NJL framework, with perhaps the earliest suggestion being that of Bjorken for a composite photon. Here we attempt to generate the entire electroweak interaction from a specific current-current, baryon number conserving form of the four fermion interaction. The W, Z and Higgs boson appear as coherent composites of all fermions, quarks and lepton, and not just of the top quark. The four fermion interaction is assumed to be valid at some high mass scale μ, perhaps the low energy limit resulting by the elimination of non-fermionic degrees of freedom from a more basic theory. The cutoff Λ, necessary in the non-renormalizable NJL may be viewed then as the proper scale for this more basic theory

  13. Anatomy of the magnetic catalysis by renormalization-group method

    Directory of Open Access Journals (Sweden)

    Koichi Hattori

    2017-12-01

    Full Text Available We first examine the scaling argument for a renormalization-group (RG analysis applied to a system subject to the dimensional reduction in strong magnetic fields, and discuss the fact that a four-Fermi operator of the low-energy excitations is marginal irrespective of the strength of the coupling constant in underlying theories. We then construct a scale-dependent effective four-Fermi interaction as a result of screened photon exchanges at weak coupling, and establish the RG method appropriately including the screening effect, in which the RG evolution from ultraviolet to infrared scales is separated into two stages by the screening-mass scale. Based on a precise agreement between the dynamical mass gaps obtained from the solutions of the RG and Schwinger–Dyson equations, we discuss an equivalence between these two approaches. Focusing on QED and Nambu–Jona-Lasinio model, we clarify how the properties of the interactions manifest themselves in the mass gap, and point out an importance of respecting the intrinsic energy-scale dependences in underlying theories for the determination of the mass gap. These studies are expected to be useful for a diagnosis of the magnetic catalysis in QCD.

  14. Analysis of Volunteer Soldiers‘ Attitudes to Service in the Lithuanian Military

    Directory of Open Access Journals (Sweden)

    Vileikienė Eglė

    2015-12-01

    Full Text Available The article presents an analysis of volunteer soldiers as a link between the Lithuanian military and society, their attitudes towards military service and their motivation to serve in the Lithuanian army. The authors looked at soldiers’ dedication to defend their Homeland and motives for serving in the Lithuanian army, presenting an assessment of the situation in the ranks and their overall satisfaction with military service. Volunteer soldiers’ expectations are also discussed, as well as their motives to remain in service, plus there are also recommendations for attracting new soldier recruits. The article concludes with the statement that Lithuanian volunteer soldiers are an important unifying link between the Lithuanian army and society, and can significantly contribute to the formation of the image of the soldier’s profession in society. Besides the social status that comes with military service and the satisfaction of financial needs, volunteer soldiers are exclusively characterised by strong patriotic feelings which determine their motivation to serve and defend their Homeland. The article’s findings rest on data from the complex sociological research study “Motivation to serve in the Ministry of Defence Volunteer Forces of the Lithuanian Military” which was conducted in April–November, 2014 by the Strategic Research Centre at the Institute of Military Science of the General Jonas Žemaitis Military Academy of Lithuania.

  15. Short-range correlations in quark and nuclear matter

    Energy Technology Data Exchange (ETDEWEB)

    Froemel, Frank

    2007-06-15

    In the first part of this thesis, the role of short-range correlations in quark matter is explored within the framework of the Nambu-Jona-Lasinio model. Starting from a next-to-leading order expansion in the inverse number of the quark colors, a fully self-consistent model constructed that employs the close relations between spectral functions and self-energies. In contrast to the usual quasiparticle approximations, this approach allows the investigation of the collisional broadening of the quark spectral function. Numerical calculations at various chemical potentials and zero temperature show that the short-range correlations do not only induce a finite width of the spectral function but also have some influence on the structure of the chiral phase transition. In the second part of this thesis, the temperature and density dependence of the nucleon spectral function in symmetric nuclear matter is investigated. The short-range correlations can be well described by a simple, self-consistent model on the one-particle-two-hole and two-particle-one-hole level (1p2h, 2p1h). The thermodynamically consistent description of the mean-field properties of the nucleons is ensured by incorporating a Skyrme-type potential. Calculations at temperatures and densities that can also be found in heavy-ion collisions or supernova explosions and the formation of neutron stars show that the correlations saturate at high temperatures and densities. (orig.)

  16. Guided bone augmentation using ceramic space-maintaining devices: the impact of chemistry

    Directory of Open Access Journals (Sweden)

    Anderud J

    2015-03-01

    Full Text Available Jonas Anderud,1,2 Peter Abrahamsson,2 Ryo Jimbo,1 Sten Isaksson,2 Erik Adolfsson,3 Johan Malmström,2 Yoshihito Naito,4 Ann Wennerberg1 1Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden; 2Maxillofacial Unit Halmstad, Region Halland, Halmstad, Sweden; 3Swedish Ceramic Institute, IVF, Mölndal, Sweden; 4Department of Oral and Maxillofacial Prosthodontics and Oral Implantology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan Abstract: The purpose of the study was to evaluate histologically, whether vertical bone augmentation can be achieved using a hollow ceramic space maintaining device in a rabbit calvaria model. Furthermore, the chemistry of microporous hydroxyapatite and zirconia were tested to determine which of these two ceramics are most suitable for guided bone generation. 24 hollow domes in two different ceramic materials were placed subperiosteal on rabbit skull bone. The rabbits were sacrificed after 12 weeks and the histology results were analyzed regarding bone-to-material contact and volume of newly formed bone. The results suggest that the effect of the microporous structure of hydroxyapatite seems to facilitate for the bone cells to adhere to the material and that zirconia enhance a slightly larger volume of newly formed bone. In conclusion, the results of the current study demonstrated that ceramic space maintaining devices permits new bone formation and osteoconduction within the dome. Keywords: hydroxyapatite, zirconia, guided bone regeneration, GBR, histology, membrane

  17. The nucleon as soliton in an effective chiral theory with polarized Dirac sea

    International Nuclear Information System (INIS)

    Meissner, T.

    1991-07-01

    We consider the Nambu-Jona-Lasinio model for SU(2) flavor with N F = 3 color degrees of freedom and a current mass m o =m u =m d , which interact via scalar-isoscalar and pseudoscalar-isovectorial 4-point coupling of the strength G. We show that it is for the soft-poin limit essentially equivalent to treat the 4-quark theory in the HFA+BSE and the bozonized theory with classical meson fields, if the collective field π with the physical pion. By the requirement that in the vacuum the experimental values for the pion mass m π =139 MeV and the weak pion decay constant f π =93 MeV are reproduced finally only one free parameter remains, which is in our case the constituent quark mass M. All other parameters and vacuum quantities can be calculated as function of M. We do this for the UV cut-off parameter Λ, the 4-quark coupling strength G, the quark current mass m O as well as the vacuum condensate (anti qq)v. Thereby especially the influence of the regularization scheme on m O and (anti q)v is studied. For the construction of states with good spin and isospin quantum numbers we apply the semiclassical cranking procedure. Finally we compare the NJL with the chiral sigma model of Gell-Mann and Levi, which is connected with the NJL by the gradient respectively heat-kernel expansion. (orig./HSI) [de

  18. Interacting fermions in rotation: chiral symmetry restoration, moment of inertia and thermodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Chernodub, M.N. [CNRS, Laboratoire de Mathématiques et Physique Théorique, Université de Tours,Tours (France); Laboratory of Physics of Living Matter, Far Eastern Federal University,Vladivostok (Russian Federation); Gongyo, Shinya [CNRS, Laboratoire de Mathématiques et Physique Théorique, Université de Tours,Tours (France); Theoretical Research Division, Nishina Center, RIKEN,Saitama (Japan)

    2017-01-30

    We study rotating fermionic matter at finite temperature in the framework of the Nambu-Jona-Lasinio model. In order to respect causality the rigidly rotating system must be bound by a cylindrical boundary with appropriate boundary conditions that confine the fermions inside the cylinder. We show the finite geometry with the MIT boundary conditions affects strongly the phase structure of the model leading to three distinct regions characterized by explicitly broken (gapped), partially restored (nearly gapless) and spontaneously broken (gapped) phases at, respectively, small, moderate and large radius of the cylinder. The presence of the boundary leads to specific steplike irregularities of the chiral condensate as functions of coupling constant, temperature and angular frequency. These steplike features have the same nature as the Shubnikov-de Haas oscillations with the crucial difference that they occur in the absence of both external magnetic field and Fermi surface. At finite temperature the rotation leads to restoration of spontaneously broken chiral symmetry while the vacuum at zero temperature is insensitive to rotation (“cold vacuum cannot rotate”). As the temperature increases the critical angular frequency decreases and the transition becomes softer. A phase diagram in angular frequency-temperature plane is presented. We also show that at fixed temperature the fermion matter in the chirally restored (gapless) phase has a higher moment of inertia compared to the one in the chirally broken (gapped) phase.

  19. Development of a Model for Dynamic Recrystallization Consistent with the Second Derivative Criterion

    Directory of Open Access Journals (Sweden)

    Muhammad Imran

    2017-11-01

    Full Text Available Dynamic recrystallization (DRX processes are widely used in industrial hot working operations, not only to keep the forming forces low but also to control the microstructure and final properties of the workpiece. According to the second derivative criterion (SDC by Poliak and Jonas, the onset of DRX can be detected from an inflection point in the strain-hardening rate as a function of flow stress. Various models are available that can predict the evolution of flow stress from incipient plastic flow up to steady-state deformation in the presence of DRX. Some of these models have been implemented into finite element codes and are widely used for the design of metal forming processes, but their consistency with the SDC has not been investigated. This work identifies three sources of inconsistencies that models for DRX may exhibit. For a consistent modeling of the DRX kinetics, a new strain-hardening model for the hardening stages III to IV is proposed and combined with consistent recrystallization kinetics. The model is devised in the Kocks-Mecking space based on characteristic transition in the strain-hardening rate. A linear variation of the transition and inflection points is observed for alloy 800H at all tested temperatures and strain rates. The comparison of experimental and model results shows that the model is able to follow the course of the strain-hardening rate very precisely, such that highly accurate flow stress predictions are obtained.

  20. What you don't know about vaccines can hurt you.

    Science.gov (United States)

    Pace, Victor M

    2015-01-01

    As physicians, we've all learned in detail about the science behind vaccinations, but I suspect few of us have been taught about the history of vaccinations. Sure, we all know that Dr. Jonas Salk developed the poliovirus vaccine, but I wasn't aware that he inoculated himself, his wife, and his three children with his then experimental vaccine. When our editorial committee decided to focus on vaccinations as our theme for this month's Greene County Medical Society's Journal, I perused the internet for interesting topics. I came across a fascinating website, historyofvaccines.org; this website is a project of the College of Physicians of Philadelphia, touted as being the oldest professional medical organization in the United States. I credit the majority of the information in this article to the above website and the rest to the National Institutes of Health (nih.gov) website; I trust that the information is valid and true, based on the agencies behind these websites. Below are some interesting tidbits about vaccine preventable diseases that I found noteworthy to pass on to our readers.

  1. Pre-critical phenomena of two-flavor color superconductivity in heated quark matter. Diquark-pair fluctuations and non-Fermi liquid behavior

    International Nuclear Information System (INIS)

    Kitazawa, Masakiyo; Kunihiro, Teiji; Koide, Tomoi; Nemoto, Yukio

    2005-01-01

    We investigate the fluctuations of the diquark-pair field and their effects on observables above the critical temperature T c in two-flavor color superconductivity (CSC) at moderate density using a Nambu-Jona-Lasinio-type effective model of QCD. Because of the strong-coupling nature of the dynamics, the fluctuations of the pair field develop a collective mode, which has a prominent strength even well above T c . We show that the collective mode is actually the soft mode of CSC. We examine the effects of the pair fluctuations on the specific heat and the quark spectrum for T above but close to T c . We find that the specific heat exhibits singular behavior because of the pair fluctuations, in accordance with the general theory of second-order phase transitions. The quarks display a typical non-Fermi liquid behavior, owing to the coupling with the soft mode, leading to a pseudo-gap in the density of states of the quarks in the vicinity of the critical point. Some experimental implications of the precursory phenomena are also discussed. (author)

  2. Quark Deconfinement in Rotating Neutron Stars

    Directory of Open Access Journals (Sweden)

    Richard D. Mellinger

    2017-01-01

    Full Text Available In this paper, we use a three flavor non-local Nambu–Jona-Lasinio (NJL model, an improved effective model of Quantum Chromodynamics (QCD at low energies, to investigate the existence of deconfined quarks in the cores of neutron stars. Particular emphasis is put on the possible existence of quark matter in the cores of rotating neutron stars (pulsars. In contrast to non-rotating neutron stars, whose particle compositions do not change with time (are frozen in, the type and structure of the matter in the cores of rotating neutron stars depends on the spin frequencies of these stars, which opens up a possible new window on the nature of matter deep in the cores of neutron stars. Our study shows that, depending on mass and rotational frequency, up to around 8% of the mass of a massive neutron star may be in the mixed quark-hadron phase, if the phase transition is treated as a Gibbs transition. We also find that the gravitational mass at which quark deconfinement occurs in rotating neutron stars varies quadratically with spin frequency, which can be fitted by a simple formula.

  3. Color superconductivity in compact stellar hybrid configurations

    Science.gov (United States)

    Ranea-Sandoval, Ignacio F.; Orsaria, Milva G.; Han, Sophia; Weber, Fridolin; Spinella, William M.

    2017-12-01

    The discovery of pulsars PSR J1614-2230 and PSR J0348+0432 with masses of around 2 M⊙ imposes strong constraints on the equations of state of cold, ultradense matter. If a phase transition from hadronic matter to quark matter were to occur in the inner cores of such massive neutron stars, the energetically favorable state of quark matter would be a color superconductor. In this study, we analyze the stability and maximum mass of such neutron stars. The hadronic phase is described by nonlinear relativistic mean-field models, and the local Nambu-Jona Lasinio model is used to describe quark matter in the 2SC+s quark phase. The phase transition is treated as a Maxwell transition, assuming a sharp hadron-quark interface, and the "constant-sound-speed" (CSS) parametrization is employed to discuss the existence of stellar twin configurations. We find that massive neutron stars such as J1614-2230 and J0348+0432 can only exist on the connected stellar branch but not on the disconnected twin-star branch. The latter can only support stars with masses that are strictly below 2 M⊙ .

  4. Predicting Solar Activity Using Machine-Learning Methods

    Science.gov (United States)

    Bobra, M.

    2017-12-01

    Of all the activity observed on the Sun, two of the most energetic events are flares and coronal mass ejections. However, we do not, as of yet, fully understand the physical mechanism that triggers solar eruptions. A machine-learning algorithm, which is favorable in cases where the amount of data is large, is one way to [1] empirically determine the signatures of this mechanism in solar image data and [2] use them to predict solar activity. In this talk, we discuss the application of various machine learning algorithms - specifically, a Support Vector Machine, a sparse linear regression (Lasso), and Convolutional Neural Network - to image data from the photosphere, chromosphere, transition region, and corona taken by instruments aboard the Solar Dynamics Observatory in order to predict solar activity on a variety of time scales. Such an approach may be useful since, at the present time, there are no physical models of flares available for real-time prediction. We discuss our results (Bobra and Couvidat, 2015; Bobra and Ilonidis, 2016; Jonas et al., 2017) as well as other attempts to predict flares using machine-learning (e.g. Ahmed et al., 2013; Nishizuka et al. 2017) and compare these results with the more traditional techniques used by the NOAA Space Weather Prediction Center (Crown, 2012). We also discuss some of the challenges in using machine-learning algorithms for space science applications.

  5. Soft deconfinement — critical phenomena at the Mott transition in a field theory for quarks and mesons

    Science.gov (United States)

    Hüfner, J.; Klevansky, S. P.; Rehberg, P.

    1996-02-01

    Critical phenomena associated with Mott transitions are investigated in the finite temperature SUf(3) Nambu-Jona-Lasinio model, that describes quarks u, d, s and bound mesons π, K. Critical exponents for the behavior close to the Mott temperature TM are determined for the static properties of a pion, such as mπ( T), gπqq( T), fπ( T), π, and the pion polarizabilities αC, N, as well as for the behavior of mK( T), gKqs( T) fK( T) in the strange sector. The effect of the Mott transitions on the q overlineq and ππ scattering lengths and for hadronization cross sections σ q overlineq→ππ (T) is discussed. Divergencies that occur in these quantities at TM indicate an intransparence with respect to hadronic and photonic probes, much like the phenomenon of critical opalescence. Physically, the Mott transition models the deconfinement transition expected of QCD since it corresponds to a delocalizayion of the bound states when the temperature is raised above TM.

  6. Dual use and the ethical responsibility of scientists.

    Science.gov (United States)

    Ehni, Hans-Jörg

    2008-01-01

    The main normative problem in the context of dual use is to determine the ethical responsibility of scientists especially in the case of unintended, harmful, and criminal dual use of new technological applications of scientific results. This article starts from an analysis of the concepts of responsibility and complicity, examining alternative options regarding the responsibility of scientists. Within the context of the basic conflict between the freedom of science and the duty to avoid causing harm, two positions are discussed: moral skepticism and the ethics of responsibility by Hans Jonas. According to these reflections, four duties are suggested and evaluated: stopping research, systematically carrying out research for dual-use applications, informing public authorities, and not publishing results. In the conclusion it is argued that these duties should be considered as imperfect duties in a Kantian sense and that the individual scientist should be discharged as much as possible from obligations which follow from them by the scientific community and institutions created for this purpose.

  7. The nucleon as a projected chiral soliton: vacuum and medium properties

    International Nuclear Information System (INIS)

    Fiolhais, M.; Alberto, P.; Ruiz Arriola, E.; Christov, C.V.; Bylgarska Akademiya na Naukite, Sofia

    1990-01-01

    Nucleon properties and nucleon form factors are computed within the framework of the projected linear chiral soliton model. To this end the Gell-Mann - Levy lagrangian is solved by means of variational methods which include angular momentum and isospin projection with trial quark-boson Fock states in generalized hedgehog configurations. The consistency of the treatment is checked by the fulfillment of virial theorems such as Goldberger-Treiman relation. In general the q 2 dependence of the nucleon form factors are well described although some of their values at zero momentum transfer come out too large, namely for the axial- and πN N- form factors. Electromagnetic form factors for the N - Δ transition are also calculated and compared with the available experimental data. Medium effects on the nucleon properties are investigated combining the projected chiral soliton model with the Nambu-Jona-Lasinio model. The latter is employed to compute the pion decay constant and the pion and sigma masses at finite medium density. These meson properties fix the parameters in the linear sigma model, which is then solved using the same variational methods as for the zero density. The nucleon mass shows a decrease of 17% and the proton radius an increase of 19% if the medium reaches nuclear matter density. The magnetic moments and g A are less affected by the medium. The nucleon electromagnetic form factors show remarkable changes at finite transfer numbers as well. (author)

  8. Effects of pair correlation functions on intermolecular nuclear relaxation by translational and rotational diffusion in liquids

    International Nuclear Information System (INIS)

    Fries, P.

    1978-01-01

    In order to study the intermolecular relaxation due to magnetic dipolar interactions, we calculate the spectral densities resulting from random translational and rotational motions of spherical molecules carrying off-centre spins. The relative translational motion is treated in the frame-work of a general diffusion equation (the Smoluchowski equation) which takes into account the existence of effective forces between the molecules. This model implies a pair correlation function. i.e. a non unifom relative distribution of the molecules. The analytical calculations are carried out by taking correctly into account the hard sphere boundary conditions for the molecules. Explicit numerical calculations of the spectral densities are performed using finite difference methods and the pair correlation function of Verlet and Weiss obtained by computer experiments. The resulting calculations allow one to interpret the relaxation exhibited by benzene and some of its monohalogen derivatives which has been measured by Jonas et al. at various pressures. The effects of pair correlation and eccentricity contribute to a noticeable enhancement of the spectral densities, especially as the frequency increases. The translational correlation times calculated from the Stokes formula and those deduced from intermolecular relaxation studies are compared. It is shown that in order to distinguish which of the dynamical models is appropriate, measurements must be made as a function of frequency [fr

  9. Phase structure of NJL model with weak renormalization group

    Science.gov (United States)

    Aoki, Ken-Ichi; Kumamoto, Shin-Ichiro; Yamada, Masatoshi

    2018-06-01

    We analyze the chiral phase structure of the Nambu-Jona-Lasinio model at finite temperature and density by using the functional renormalization group (FRG). The renormalization group (RG) equation for the fermionic effective potential V (σ ; t) is given as a partial differential equation, where σ : = ψ bar ψ and t is a dimensionless RG scale. When the dynamical chiral symmetry breaking (DχSB) occurs at a certain scale tc, V (σ ; t) has singularities originated from the phase transitions, and then one cannot follow RG flows after tc. In this study, we introduce the weak solution method to the RG equation in order to follow the RG flows after the DχSB and to evaluate the dynamical mass and the chiral condensate in low energy scales. It is shown that the weak solution of the RG equation correctly captures vacuum structures and critical phenomena within the pure fermionic system. We show the chiral phase diagram on temperature, chemical potential and the four-Fermi coupling constant.

  10. Chiral symmetry and quark-antiquark pair creation in a strong color-electromagnetic field

    International Nuclear Information System (INIS)

    Suganuma, Hideo; Tatsumi, Toshitaka.

    1993-01-01

    We study the manifestation of chiral symmetry and q-q-bar pair creation in the presence of the external color-electromagnetic field, using the Nambu-Jona-Lasinio model. We derive the compact formulae of the effective potential, the Dyson equation for the dynamical quark mass and the q-q-bar pair creation rate in the covariantly constant color-electromagnetic field. Our results are compared with those in other approaches. The chiral-symmetry restoration takes place by a strong color-electric field, and the rapid reduction of the dynamical quark mass is found around the critical field strength, ε cr ≅4GeV/fm. Natural extension to the three-flavor case including s-quarks is also done. Around quarks or antiquarks, chiral symmetry would be restored by the sufficiently strong color-electric field, which may lead to the chiral bag picture of hadrons. For the early stage for ultrarelativistic heavy-ion collisions, the possibility of the chiral-symmetry restoration is indicated in the central region just after the collisions. (author)

  11. "Alguses oli tema üksinda, sest oli küll..." : [luuletused] / Kabir ; tlk. Doris Kareva

    Index Scriptorium Estoniae

    Kabir

    2006-01-01

    Sisu: "Alguses oli tema üksinda, sest oli küll..." ; "Kõik loodud on Kõiksuse poolt..." ; "Otsid Sa mind?..." ; "Kabir oma meele puhtaks..." ; "Pole pühades järvedes midagi muud peale vee..." ; "Otsisin kelme ja kõveraid..." ; "Ütle, vend, mida küll teha..." ; "Mis kurja on teinud su juuksed..." ; "Ära tõuse, et minna õue vaatama lilli..." ; "Sinu sünd inimesena on küps vili..." ; "Öö saatsid sa magades mööda..." ; "Pole ma hindu..." ; "Ma vaatan sind..." ; "Veskikivisid vaadeldes ; "Nähes aednikku lähenemas, õhkasid pungad..." ; "Tasa, tasa tõtta, mu meel..." ; "Ära kurvasta..." ; "Imetlusväärne on teemant..." ; "Kuula, sõber, see keha on Tema lüüra..." ; "Nagu seemnes varjul on õli..." ; "Olgugi ookean leekides..." ; "Tilka, mis lahustub meres..." ; "Jõgi ja lained on üks..." ; "Kes sa oled ja kust oled tulnud?..." ; "Kaovad kuningad, kauneimad kuningannad..." ; "Rohkem kui midagi muud..." ; "Lihalik, surelik tantsib selle ees..." ; "Väike rubiin, mida igaüks ihkab..." ; "Mine heade juurde, kus Armastatugi elab..." ; "Eksitus sulgeb väravad..." ; "Keelilt vallandub helisid..." ; "Kõik algab lahusoleku valust..." ; "Ärka, sõber! Miks ikka veel magad?..." ; "Kuu on mu kehas, kuid ise ma seda ei näe..." ; "Miks oled nii kärsitu, süda?..." ; "Kellele kuulub see flööt..." ; "Kui raske on Külalist kohata!..." ; "Kandetool toodi minule järgi mu isakoju..." ; "Siia ilma sündides nutsid..." ; "Oh mu süda! Ei jõudnud sa tundma õppida..." ; "Õige kulunud on sinu rüü..." ; "Õhkõrn on see õhuke rüü..." ; "Lipp, mida keegi ei näe..." ; "Oh otsija, lihtne liit lähim on südamele..." ; "Õhtu varjud on sügavaks saanud..." ; "Kuis saakski katkeda armastus me kahe vahel..." ; "Luik, tahaksin, et mulle räägiksid kõik oma loo..." ; "Kuhu ihaled küll, minu süda?..." ; "Ei lakka Lõpmatu flöödiheli..." ; "Mida näed, seda pole...". Autori kohta eluloolisi andmeid lk. 11

  12. POTENSI BIJI DAN EKSTRAK BIJI TERATAI (Nymphaea pubescens Willd SEBAGAI PENCEGAH DIARE PADA TIKUS PERCOBAAN YANG DIINTERVENSI E.coli ENTEROPATOGENIK

    Directory of Open Access Journals (Sweden)

    Yuspihana Fitrial

    2013-03-01

    pemberian ekstrak biji teratai dapat mencegah kerusakan pada vili usus halus akibat dari serangan E.colienteropatogenik. Berdasarkan penelitian ini, baik bjii teratai maupun ekstrak biji teratai mengandung senyawa aktifyang mampu mencegah dan menghambat pertumbuhan E.coli penyebab diare.Kata kunci: Biji teratai, Enterophatogenic Escherichia coli, ekstrak etil asetat, antibakteri, diare

  13. Tecnociência, democracia e os desafios éticos das biotecnologias no Brasil Technoscience, democracy, and ethical challenges of biotechnology in Brazil

    Directory of Open Access Journals (Sweden)

    Cristiane Amaro da Silveira

    2008-06-01

    Full Text Available O crescente questionamento das idéias evolucionistas e das grandes narrativas que serviram de suporte, desde os clássicos, aos estudos nas áreas das ciências sociais tem desencadeado reações diversas no âmbito acadêmico. Se as tendências pós-modernas e as teses do fim da História se situam legitimamente neste espaço de possibilidades, não menos influentes são as propostas de releitura da realidade em que vivemos, a partir do projeto moderno e sua radicalização. É dentro deste último empreendimento que Anthony Giddens propõe a perspectiva de um novo pacto de segurança ontológica, que passa a ser construído em um mundo de sistemas abstratos que precisam ser reencaixados em dimensões globais. As discussões envolvendo as novas biotecnologias, em nível mundial e no Brasil, são reveladoras de características interessantes deste novo momento da humanidade. Os pontos de acesso desencadeados por pavores alimentares e preocupações ambientais fazem, neste sentido, mais do que diminuir a fidedignidade em relação ao conhecimento perito; provocam reordenamentos de implicações éticas, sociais e políticas bastante distintos da "heurística do medo", proposta pelo filósofo Hans Jonas. Como tais reordenamentos sinalizam para novas tendências no processo de gestão das tecnologias à luz da recente polêmica configurada em torno das novas biotecnologias no Brasil? É sobre esta questão que o presente texto pretende refletir.The increasing questioning of the evolutionist ideas and the great narratives, the classics that served as support to the studies in the field of social sciences, has led to many different reactions within the academic context. Even though the post-modern trends and theories of the end of history have a right to be in this set of possibilities, no less influential are the proposals for revising the reality in which we live from the point of view of the modern project and its radicalization. It is within

  14. Pyrrhopyginae: gêneros novos e revalidados (Lepidoptera, Hesperiidae Pyrrhopyginae: new and revalidated genera (Lepidoptera, Hespe-riidae

    Directory of Open Access Journals (Sweden)

    Olaf H.H. Mielke

    2002-03-01

    Full Text Available The following new genera with their type-species are described: Oxynetrini: Cyclopyge gen. n. - type-species: Pyrrhopyge roscius Hopffer, 1874; Pyrrhopygini: Arnysoria gen. n. - type species: Pyrrhopyga [sic] galgala Hewitson, 1866, Chalypyge gen. n. - type species: Pyrrhopyga [sic] chalybea Scudder, 1872, Creonpyge gen. n. - type species: Pyrrhopyga [sic] creon H. Druce, 1874, Cyanopyge gen. n. - type species: Pyrrhopyge sangaris Skinner, 1921, Gunayan gen. n. - type species: Pyrrhopyga [sic] rhacia Hewitson, 1875, Jonaspyge gen. n. - type species: Pyrrhopyga [sic] Jonas C. Felder & R. Felder, 1859, Melanopyge gen. n. - type species: Pyrrhopyga [sic] maculosa Hewitson, 1866, Mimardaris gen. n. - type species: Pyrrhopyga [sic] sela Hewitson, 1866, Mysarbia gen. n. - type species: Pyrrhopyge sejanus Hopffer, 1874, Ochropyge gen. n. - type species: Pyrrhopyge ruficauda Hayward, 1932. Apyrrothrix Lindsey, 1921 and Yanguna Watson, 1893 are revalidated. The following are revalidated combinations: Apyrrothrix araxes (Hewitson, 1867, Apyrrothrix arizonae (Godman & Salvin, 1893, Yanguna cometes cometes (Cramer, 1770, Yanguna cometes cometides Mabille & Boullet, 1908, Yanguna cometes staudingeri (Plštz, 1879, Yanguna cosyra (H. Druce, 1875, Yanguna spatlosa spatlosa (Hewitson, 1871, Yanguna spatlosa aspllos Mabille & Boullet, 1908, Yanguna spatlosa mabillei H.H. Druce, 1909, Yanguna tetricus Bell, 1931, Yanguna thelersa (Hewitson, 1866, The following are new combinations: Cyclopyge roscius roscius (Hopffer, 1874, Cyclopyge roscius flavomaculata (Bell, 1937, Cyclopyge roscius iphimedia (Plštz, 1886, Yanguna erebus (Plštz, 1879, Gunayan rhacia (Hewitson, 1875, Gunayan rubrlcollts (Sepp, [1841], Gunayan timaeus (Bell, 1931, Chalypyge chalybea chalybea (Scudder, 1872, Chalypyge chalybea chlorts (Evans, 1951, Chalypyge zereda zereda (Hewitson, 1866, Chalypyge zereda hygieia (C. Felder & R. Felder, 1867, Chalypyge zereda insana (Staudinger, 1876, Chalypyge

  15. Sorafenib inhibits tumor growth and vascularization of rhabdomyosarcoma cells by blocking IGF-1R-mediated signaling

    Directory of Open Access Journals (Sweden)

    Wessen Maruwge

    2008-11-01

    Full Text Available Wessen Maruwge1, Pádraig D’Arcy1, Annika Folin1,2, Slavica Brnjic1, Johan Wejde1, Anthony Davis1, Fredrik Erlandsson3, Jonas Bergh1,2, Bertha Brodin11Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden; 2Radiumhemmet, Karolinska University Hospital, Stockholm, Sweden; 3Bayer Pharmaceutical Corporation, SwedenAbstract: The growth of many soft tissue sarcomas is dependent on aberrant growth factor signaling, which promotes their proliferation and motility. With this in mind, we evaluated the effect of sorafenib, a receptor tyrosine kinase inhibitor, on cell growth and apoptosis in sarcoma cell lines of various histological subtypes. We found that sorafenib effectively inhibited cell proliferation in rhabdomyosarcoma, synovial sarcoma and Ewing’s sarcoma with IC50 values <5 µM. Sorafenib effectively induced growth arrest in rhabdomyosarcoma cells, which was concurrent with inhibition of Akt and Erk signaling. Studies of ligand-induced phosphorylation of Erk and Akt in rhabdomyosarcoma cells showed that insulin-like growth factor-1 is a potent activator, which can be blocked by treatment with sorafenib. In vivo sorafenib treatment of rhabdomyosarcoma xenografts had a significant inhibitory effect on tumor growth, which was associated with inhibited vascularization and enhanced necrosis in the adjacent tumor stroma. Our results demonstrate that in vitro and in vivo growth of rhabdomyosarcoma can be suppressed by treatment with sorafenib, and suggests the possibilities of using sorafenib as a potential adjuvant therapy for the treatment of rhabdomyosarcoma.Keywords: soft tissue sarcoma, kinase inhibitors, targeted therapy, vascularization

  16. Composite antisymmetric tensor bosons in a four-fermion interaction model

    International Nuclear Information System (INIS)

    Dmitrasinovic, V.

    2000-01-01

    We discuss the phenomenological consequences of the U A (1) symmetry-breaking two-flavour four-fermion antisymmetric (AS) Lorentz tensor interaction Lagrangians. We use the recently developed methods that respect the 'duality' symmetry of this interaction. Starting from the Fierz transform of the two-flavour 't Hooft interaction (a four-fermion Lagrangian with AS tensor interaction terms augmented by Nambu and Jona-Lasinio (NJL)-type Lorentz scalar interaction responsible for dynamical symmetry breaking and quark mass generation), we find the following. (a) Four antisymmetric tensor and four AS pseudotensor bosons exist which satisfy a mass relation previously derived for scalar and pseudoscalar mesons from the 't Hooft interaction. (b) Antisymmetric tensor bosons mix with vector bosons via one-fermion-loop effective couplings so that both kinds of bosons have their masses shifted and the fermions (quarks) acquire anomalous magnetic moment form factors that explicitly violate chiral symmetry. (c) The mixing of massive AS tensor fields with vector fields leads to two sets of spin-1 states. The second set of spin-1 mesons is heavy and has not been observed. Moreover, at least one member of this second set is tachyonic, under standard assumptions about the source and strength of the AS tensor interaction. The tachyonic state also shows up as a pole in the space-like region of the electromagnetic form factors. (d) The mixing of axial-vector fields with antisymmetric tensor bosons is proportional to the (small) isospin-breaking up-down quark mass difference, so the mixing-induced mass shift is negligible. (e) The AS tensor version of the Veneziano-Witten U A (1) symmetry-breaking interaction does not lead to tachyons, or any AS tensor field propagation to leading order in N C . (author)

  17. RELAÇÕES ENTRE ÉTICA ORGANIZACIONAL, INOVAÇÕES AMBIENTAIS E SUSTENTABILIDADE

    Directory of Open Access Journals (Sweden)

    Pedro Gilberto Aloise

    2017-06-01

    Full Text Available O objetivo deste artigo é analisar o comportamento ético das organizações em relação a sustentabilidade e as inovações ambientais, através de uma revisão da literatura.  O estudo buscou identificar a convergência entre o conceito de desenvolvimento sustentável e as ideias de Kant, Georgescu-Roegen e Jonas, contextualizando as bases filosóficas do comportamento ético e o praticado pelas organizações. Em seguida apresentam-se as principais características das inovações sustentáveis e sua importância para a mitigação de riscos ambientais em prol da sustentabilidade. O artigo apresenta diversos fatores que impactam as decisões sobre inovações e sustentabilidade e o comportamento das organizações ao buscarem uma atitude ética compatível com esses paradigmas. Dentre os resultados encontrados estão: o estabelecimento de crenças e valores que objetivam melhorar a reputação das empresas; a compatibilidade e a coexistência entre ética e inovação (“inovação ética” e “inovação responsável”. A influência da cultura ética sobre a capacidade de inovar e as razões pelas quais muitos empresários resistem em desenvolver e adotar inovações ainda é um dos entraves que a lógica produtivista do capital impõe as práticas de gestão. Ao final se apresentam algumas limitações da pesquisa e sugestões para estudos futuros.

  18. [Towards a new vaccine economy?].

    Science.gov (United States)

    Poirot, P; Martin, J F

    1994-01-01

    When Jonas Salk announced in the mid-50s the availability of a new vaccine against poliomyelitis, the world had the impression that it was now controlling infectious diseases. In fact, the success of this vaccine has been considerable and although some innovations lead to the launch of vaccines against flu, measles, rubella or mumps, the world vaccine market remained remarkably stable till the mid-80s. However, since 1984 (launch of the hepatitis B vaccine) there have been very substantial changes and further change is expected in the next ten years in the world market. Today, big companies are making a concentrated supply: Pasteur Mérieux with its subsidiary Connaught, SmithKline Beecham who acquired the Belgian company RIT, and Merck & Co. who is joining its forces with Pasteur Mérieux. Medium sized and small companies remain and reflect the situation of the past, but must work hard to secure their long term existence eventhough the world demand is going to double before the year 2000. Very substantial technological innovations explain to a large extent the development of the supply: progress in molecular biology, and particularly genetic engineering, lead to recombinant vaccines of which hepatitis B is the best example with worldwide sales in the range of $600 million a year. Similarly, conjugation technologies have allowed the development of new vaccines against meningitis, particularly Haemophilus influenzae type b. More recently, an efficacious vaccine against hepatitis A has been launched and many new products will be marketed in the next years against herpes, Lyme disease, and agents of other meningitis, etc.(ABSTRACT TRUNCATED AT 250 WORDS)

  19. Ethics Beyond Finitude: Responsibility towards Future Generations and Nuclear Waste Management

    International Nuclear Information System (INIS)

    Loefquist, Lars

    2008-01-01

    This dissertation has three aims: 1. To evaluate several ethical theories about responsibility towards future generations. 2. To construct a theory about responsibility towards future generations. 3. To carry out an ethical evaluation of different nuclear waste management methods. Five theories are evaluated with the help of evaluative criteria, primarily: A theory must provide future generations with some independent moral status. A theory should acknowledge moral pluralism. A theory should provide some normative claims about real-world problems. Derek Parfit's theory provides future generations with full moral status. But it is incompatible with moral pluralism, and does not provide reasonable normative claims about real-world problems. Brian Barry's theory provides such claims and a useful idea about risk management, but it does not provide an argument why future generations ought to exist. Avner de-Shalit's theory explains why they ought to exist; however, his theory can not easily explain why we ought to care for other people than those in our own community. Emmanuel Agius' theory gives an ontological explanation for mankind's unity, but reduces conflicts of interests to a common good. Finally, Hans Jonas' theory shifts the focus from the situation of future generations to the preconditions of human life generally. However, his theory presupposes a specific ontology, which might be unable to motivate people to act. The concluding chapters describe a narrative theory of responsibility. It claims that we should comprehend ourselves as parts of the common story of mankind and that we ought to provide future generations with equal opportunities. This implies that we should avoid transferring risks and focus on reducing the long-term risks associated with the nuclear waste

  20. Integrating out the Dirac sea

    International Nuclear Information System (INIS)

    Karbstein, Felix

    2009-01-01

    We introduce a new method for dealing with fermionic quantum field theories amenable to a mean-field-type approximation. In this work we focus on the relativistic Hartree approximation. Our aim is to integrate out the Dirac sea and derive a no-sea effective theory'' with positive energy single particle states only. As the derivation of the no-sea effective theory involves only standard Feynman diagrams, our approach is quite general and not restricted to particular space-time dimensions. We develop and illustrate the approach in the ''large N'' limit of the Gross-Neveu model family in 1+1 dimensions. As the Gross-Neveu model has been intensely studied and several analytical solutions are known for this model, it is an ideal testing ground for our no-sea effective theory approach. The chiral Gross-Neveu model, also referred to as 1+1 dimensional Nambu-Jona-Lasinio model, turns out to be of particular interest. In this case, we explicitly derive a consistent effective theory featuring both elementary ''π meson'' fields and (positive energy) ''quark'' fields, starting from a purely fermionic quantum field theory. In the second part of this work, we apply our approach to the Walecka model in 1+1 and 3+1 dimensions. As the Dirac sea caused considerable difficulties in attempts to base nuclear physics on field theoretic models like the Walecka model, mean-field calculations were typically done without the sea. We confront several of these mean-field theory results with our no-sea effective theory approach. The potential of our approach is twofold. While the no-sea effective theory can be utilized to provide new analytical insights in particular parameter regimes, it also sheds new light on more fundamental issues as the explicit emergence of effective, Dirac-sea induced multi-fermion interactions in an effective theory with positive energy states only. (orig.)

  1. Fifteen Challenges in Establishing a Multidisciplinary Research Program on eHealth Research in a University Setting: A Case Study.

    Science.gov (United States)

    Grönqvist, Helena; Olsson, Erik Martin Gustaf; Johansson, Birgitta; Held, Claes; Sjöström, Jonas; Lindahl Norberg, Annika; Hovén, Emma; Sanderman, Robbert; van Achterberg, Theo; von Essen, Louise

    2017-05-23

    U-CARE is a multidisciplinary eHealth research program that involves the disciplines of caring science, clinical psychology, health economics, information systems, and medical science. It was set up from scratch in a university setting in 2010, funded by a governmental initiative. While establishing the research program, many challenges were faced. Systematic documentation of experiences from establishing new research environments is scarce. The aim of this paper was to describe the challenges of establishing a publicly funded multidisciplinary eHealth research environment. Researchers involved in developing the research program U-CARE identified challenges in the formal documentation and by reflecting on their experience of developing the program. The authors discussed the content and organization of challenges into themes until consensus was reached. The authors identified 15 major challenges, some general to establishing a new research environment and some specific for multidisciplinary eHealth programs. The challenges were organized into 6 themes: Organization, Communication, Implementation, Legislation, Software development, and Multidisciplinarity. Several challenges were faced during the development of the program and several accomplishments were made. By sharing our experience, we hope to help other research groups embarking on a similar journey to be prepared for some of the challenges they are likely to face on their way. ©Helena Grönqvist, Erik Martin Gustaf Olsson, Birgitta Johansson, Claes Held, Jonas Sjöström, Annika Lindahl Norberg, Emma Hovén, Robbert Sanderman, Theo van Achterberg, Louise von Essen. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 23.05.2017.

  2. Dealloying of Cu{sub x}Au studied by hard X-ray photoelectron spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Rajput, Parasmani, E-mail: parasmani.rajput@northwestern.edu [European Synchrotron Radiation Facility, 6 rue Jules Horowitz, F-38043 Grenoble (France); Gupta, Ajay [UGC-DAE Consortium for Scientific Research, University Campus, Khandwa Road, Indore 452 017 (India); Detlefs, Blanka [European Synchrotron Radiation Facility, 6 rue Jules Horowitz, F-38043 Grenoble (France); Kolb, Dieter M. [Institute for Electrochemistry, University of Ulm, D-89069 Ulm (Germany); Potdar, Satish [UGC-DAE Consortium for Scientific Research, University Campus, Khandwa Road, Indore 452 017 (India); Zegenhagen, Jörg [European Synchrotron Radiation Facility, 6 rue Jules Horowitz, F-38043 Grenoble (France)

    2013-10-15

    Highlights: ► The shift in binding energy of Cu and Au lines in CuAu alloys is opposite to expected from the nobility of the elements. ► The magnitude of the chemical shifts of the metal lines in CuAu alloys is strongly influenced by finite size effects and disorder. ► Cu 3s and/or Au 4f cross-sections are not well described by theory (Scofield). The Cu 3s photoabsorption cross-section seems to be strongly overestimated. ► We find/confirm that (CuAu) dealloying proceeds into depth like a spinodal decomposition. -- Abstract: We studied pristine and leached ultra-thin Cu{sub x}Au (x ≈ 4) films by hard X-ray photoelectron spectroscopy. The Au 4f and Cu 3s core levels show a shift in binding energy which is opposite to expected from the nobility of the elements, which is explained by charge transfer involving differently screening s and d valence levels of the elements [W. Eberhardt, S.C. Wu, R. Garrett, D. Sondericker, F. Jona, Phys. Rev. B 31 (1985) 8285]. The magnitude of the chemical shifts of the metal lines is strongly influenced by the finite size and disorder of the films. Angular dependent photoelectron emission allowed to assess the alloy composition as a function of depth larger than 5 nm. The potential controlled dealloying proceeds into depth like a spinodal decomposition with Cu going into solution and the remaining Au accumulating in the surface region. The compositional gradient did not lead to a significant broadening of the metal photoelectron lines suggesting a non-local screening mechanism.

  3. SU(3)味极限附近色味连锁型超导体中的束缚双夸克态%Bound Diquark States in Color-Flavor-Locked Type Superconductor near the SU(3) Flavor Limit

    Institute of Scientific and Technical Information of China (English)

    任春福; 张一; 张小兵

    2011-01-01

    Starting from the ideal color-flavor locked phase, an approximate description for three-flavor quark superconductor is proposed near the SU (3) flavor limit. Under the physical influence from explicitly chiral-symmetry-breaking, we investigate the behaviors for two species of diquark states and the formations of bound diquark states at the mean-field level. In strongly coupling density regime, a theoretical possibility is pointed out at the first time,that Bose-Einstein condensation of light-flavor diquark states occur in the environment where all three-flavor and three-color quarks participate the Bardeen-Cooper-Schrieffer pairing.%从理想的色味连锁相出发,在SU(3)味极限附近,给出了一个3味夸克超导体的近似描述.在手征对称性明显破缺的物理影响下,运用Nambu-Jona-Lasinio(NJL)模型在平均场层次上研究了两种双夸克态和束缚双夸克态的形成.当夸克之间的相互作用非常强时,首次指出了在3色和3味夸克参与Bardeen-Cooper-Schrieffer配对的环境下,轻味双夸克态发生玻色-爱因斯坦凝聚的可能性.

  4. Operation, maintenance and utilization of the RA reactor - Report on operation in 1979; Pogon, odrzavanje i eksploatacija reaktora RA, Izvestaj o radu u 1979. godini

    Energy Technology Data Exchange (ETDEWEB)

    Milosevic, M

    1979-12-15

    During 1979 the RA reactor was in operation only three months, i.e. only 24% of the planned activity was achieved. The reactor operation was interrupted in March due to problems that could not be solved by the existing equipment. Alkalinity of the heavy water resulting from the existing ammonia ions could not be removed by the existing distillation system. In addition deposition of aluminium oxyhydrate on the fuel elements was increased. This was noticed during routine control when the reactor was shutdown for refueling. The decision of the Director general of the Institute and sanitary Inspector followed, prohibiting further reactor operation. A separate chapter of this report is devoted to the analysis of the difficulties and possible solution of the problem in cooperation with the experts from different laboratories of the Institute. Aged and damaged instruments at the reactor were not exchange due to lack of budget. During the operation there were no accidents. [Serbo-Croat] U toku 1979. godine plan rada ostvaren je sa 24%, odnosno reaktor je radio samo prva tri meseca. U martu je doslo do prekida rada reaktora zbog pojave koja se nije mogla otkloniti postojecom opremom. Alkalnost teske vode, posledica prisustva amonijum jona, ne moze se odstraniti sistemom destilacije. Pored toga usled dotrajalosti opreme povecano je talozenje aluminijum oksihidroksida na gorivnim elementima. Ova pojava uocena je tokom rutinske kontrole prilikom izmene goriva a usledila je obustava rada resenjem Direktora i sanitarnog inspektora. Posebno poglavlje ovog izvestaja posveceno je analizi teskoca u radu i reaktora i resavanju nastalih problema sa gorivom u saradnji sa saradnicima drugih laboratorija Instituta. Dotrajali uredjaji i oprema nisu zamenjeni usled nedostatka sredstava. U toku rada nije bilo akcidenata.

  5. Sleep Disordered Breathing During Live High-Train Low in Normobaric Versus Hypobaric Hypoxia.

    Science.gov (United States)

    Saugy, Jonas J; Schmitt, Laurent; Fallet, Sibylle; Faiss, Raphael; Vesin, Jean-Marc; Bertschi, Mattia; Heinzer, Raphaël; Millet, Grégoire P

    2016-09-01

    Saugy, Jonas J., Laurent Schmitt, Sibylle Fallet, Raphael Faiss, Jean-Marc Vesin, Mattia Bertschi, Raphaël Heinzer, and Grégoire P. Millet. Sleep disordered breathing during live high-train low in normobaric versus hypobaric hypoxia. High Alt Med Biol. 17:233-238, 2016.-The present study aimed to compare sleep disordered breathing during live high-train low (LHTL) altitude camp using normobaric hypoxia (NH) and hypobaric hypoxia (HH). Sixteen highly trained triathletes completed two 18-day LHTL camps in a crossover designed study. They trained at 1100-1200 m while they slept either in NH at a simulated altitude of 2250 m or in HH. Breathing frequency and oxygen saturation (SpO 2 ) were recorded continuously during all nights and oxygen desaturation index (ODI 3%) calculated. Breathing frequency was lower for NH than HH during the camps (14.6 ± 3.1 breath × min -1 vs. 17.2 ± 3.4 breath × min -1 , p < 0.001). SpO 2 was lower for HH than NH (90.8 ± 0.3 vs. 91.9 ± 0.2, p < 0.001) and ODI 3% was higher for HH than NH (15.1 ± 3.5 vs. 9.9 ± 1.6, p < 0.001). Sleep in moderate HH is more altered than in NH during a LHTL camp.

  6. Quality of oral surgery referrals and how to improve them

    Directory of Open Access Journals (Sweden)

    Bjorkeborn M

    2017-11-01

    Full Text Available Mikael Björkeborn,1 Henrik Nilsson,2 Jonas Anderud1 1Department of Oral and Maxillofacial Surgery, Halmstad Hospital, Halmstad, Sweden; 2Department of Oral and Maxillofacial Surgery, Växjö Hospital, Växjö, Sweden Aim: To assess the quality of routine oral surgery referrals received at Halmstad Hospital and Växjö Hospital and to emphasize areas for improvement. Method: A retrospective study was performed on all routine oral surgery referrals received between 2014 and 2015 at both Halmstad Hospital and Växjö Hospital. A total of 1,891 referral letters were assessed for their quality against a predetermined checklist of basic requirements of a satisfactory referral. The referrals were also categorized according to if it was sent by a male, female, private dental service, or the Swedish Public Dental Health service. Results: A diagnosis was missing in 30% of all referrals. Radiographs and information about previous radiographic examinations were not included in 10% of the referrals. Of those referrals that included radiographs, only around half were deemed adequate for diagnostic purposes. The presenting complaint was missing in 40% of all referrals. Current medical history was absent in 40% and current medication was omitted in 60% of the referrals. Information about tobacco use was only included in 10% of all referrals. Overall, female referrers performed better than male colleagues. Private referrals more regularly included information about diagnosis, previous treatment, and current medication. On the other hand, referrals from the public dental health service more frequently included radiographs, tobacco use, and current medical history. Conclusion: There is plenty of room for improving the standards of oral surgery referrals. We suggest that future electronic referral systems should only allow for submission once all of the essential information has been considered. Keywords: clinical audit, referral quality, oral surgery referrals

  7. Static and dynamic characteristics of various mesons and the deuteron. Author-review of the Thesis

    International Nuclear Information System (INIS)

    Secansky, M.

    2009-01-01

    The Dissertation is concerned of static and dynamic characteristics of various mesons and the deuteron, which are defined in the Introduction. Special attention is payed to the electromagnetic polarizabilities of pions in the Chapter I and the Chapter II. While in the Chapter I is represented a review of present theoretical and experimental situation of the pion polarizabilities, in the Chapter II the problem of an ambiguous determination of the sum and the difference of the neutral pion polarizabilities is solved by the unambiguous determination of a meson parameters with the help of the pion scalar form factor and the calculation and the two photon decay of σ meson in the framework of the linearized Nambu-Jona-Lasinio type Lagrangian. In the Chapter III the new deuteron - proton sum rule is derived, by means of which and data on the corresponding physical quantities in the sum rule the mean -square - charge radius of the deuteron is numerically evaluated to be in a satisfactory agreement with the dispersion relations prediction. In the Chapter IV by means of the special Lagrangian of the quark - meson interactions the decay width of φ → f 0 (980)γ and the total cross - section of the e + e - → γ * → φf 0 (980) process is predicted. In the last Chapter V we have tried to solve the conflict between the measured and theoretically predicted branching ratio of the process π 0 → e + e - decay by the inclusion of the double - logarithmic QED radiative corrections. Despite of the latter, the discrepancy between the theoretical prediction and the experimental result for the π 0 → e + e - decay was not removed and further independent experimental and theoretical efforts have to be continued. (Author)

  8. Evaluation of weather forecast systems for storm surge modeling in the Chesapeake Bay

    Science.gov (United States)

    Garzon, Juan L.; Ferreira, Celso M.; Padilla-Hernandez, Roberto

    2018-01-01

    Accurate forecast of sea-level heights in coastal areas depends, among other factors, upon a reliable coupling of a meteorological forecast system to a hydrodynamic and wave system. This study evaluates the predictive skills of the coupled circulation and wind-wave model system (ADCIRC+SWAN) for simulating storm tides in the Chesapeake Bay, forced by six different products: (1) Global Forecast System (GFS), (2) Climate Forecast System (CFS) version 2, (3) North American Mesoscale Forecast System (NAM), (4) Rapid Refresh (RAP), (5) European Center for Medium-Range Weather Forecasts (ECMWF), and (6) the Atlantic hurricane database (HURDAT2). This evaluation is based on the hindcasting of four events: Irene (2011), Sandy (2012), Joaquin (2015), and Jonas (2016). By comparing the simulated water levels to observations at 13 monitoring stations, we have found that the ADCIR+SWAN System forced by the following: (1) the HURDAT2-based system exhibited the weakest statistical skills owing to a noteworthy overprediction of the simulated wind speed; (2) the ECMWF, RAP, and NAM products captured the moment of the peak and moderately its magnitude during all storms, with a correlation coefficient ranging between 0.98 and 0.77; (3) the CFS system exhibited the worst averaged root-mean-square difference (excepting HURDAT2); (4) the GFS system (the lowest horizontal resolution product tested) resulted in a clear underprediction of the maximum water elevation. Overall, the simulations forced by NAM and ECMWF systems induced the most accurate results best accuracy to support water level forecasting in the Chesapeake Bay during both tropical and extra-tropical storms.

  9. Introduction to finite temperature and finite density QCD

    International Nuclear Information System (INIS)

    Kitazawa, Masakiyo

    2014-01-01

    It has been pointed out that QCD (Quantum Chromodynamics) in the circumstances of medium at finite temperature and density shows numbers of phenomena similar to the characteristics of solid state physics, e.g. phase transitions. In the past ten years, the very high temperature and density matter came to be observed experimentally at the heavy ion collisions. At the same time, the numerical QCD analysis at finite temperature and density attained quantitative level analysis possible owing to the remarkable progress of computers. In this summer school lecture, it has been set out to give not only the recent results, but also the spontaneous breaking of the chiral symmetry, the fundamental theory of finite temperature and further expositions as in the following four sections. The first section is titled as 'Introduction to Finite Temperature and Density QCD' with subsections of 1.1 standard model and QCD, 1.2 phase transition and phase structure of QCD, 1.3 lattice QCD and thermodynamic quantity, 1.4 heavy ion collision experiments, and 1.5 neutron stars. The second one is 'Equilibrium State' with subsections of 2.1 chiral symmetry, 2.2 vacuum state: BCS theory, 2.3 NJL (Nambu-Jona-Lasinio) model, and 2.4 color superconductivity. The third one is 'Static fluctuations' with subsections of 3.1 fluctuations, 3.2 moment and cumulant, 3.3 increase of fluctuations at critical points, 3.4 analysis of fluctuations by lattice QCD and Taylor expansion, and 3.5 experimental exploration of QCD phase structure. The fourth one is 'Dynamical Structure' with 4.1 linear response theory, 4.2 spectral functions, 4.3 Matsubara function, and 4.4 analyses of dynamical structure by lattice QCD. (S. Funahashi)

  10. Effective field theories of baryons and mesons, or, what do quarks do?

    International Nuclear Information System (INIS)

    Keaton, G.L.

    1995-01-01

    This thesis is an attempt to understand the properties of the protons, pions and other hadrons in terms of their fundamental building blocks. In the first chapter the author reviews several of the approaches that have already been developed. The Nambu-Jona-Lasinio model offers the classic example of a derivation of meson properties from a quark Lagrangian. The chiral quark model encodes much of the intuition acquired in recent decades. The author also discusses the non-linear sigma model, the Skyrme model, and the constituent quark model, which is one of the oldest and most successful models. In the constituent quark model, the constituent quark appears to be different from the current quark that appears in the fundamental QCD Lagrangian. Recently it was proposed that the constituent quark is a topological soliton. In chapter 2 the author investigates this soliton, calculating its mass, radius, magnetic moment, color magnetic moment, and spin structure function. Within the approximations used, the magnetic moments and spin structure function cannot simultaneously be made to agree with the constituent quark model. In chapter 3 the author uses a different plan of attack. Rather than trying to model the constituents of the baryon, he begins with an effective field theory of baryons and mesons, with couplings and masses that are simply determined phenomenologically. Meson loop corrections to baryon axial currents are then computed in the 1/N expansion. It is already known that the one-loop corrections are suppressed by a factor 1/N; here it is shown that the two-loop corrections are suppressed by 1/N 2 . To leading order, these corrections are exactly the same as would be calculated in the constituent quark model. This method therefore offers a different approach to the constituent quark

  11. Implicancias bioéticas y neuroéticas del cambio climático y sus efectos sobre la salud

    Directory of Open Access Journals (Sweden)

    Marcelo Gorga

    2016-01-01

    Full Text Available Los riesgos para la salud asociados al cambio climático son múltiples y afectan particularmente a aquellas pobla-ciones en condiciones de pobreza. Con base en la lectura y análisis crítico de publicaciones científicas vinculadas al cambio climático y la salud, en este artículo se propone el objetivo de responder a la pregunta acerca de qué valores y derechos humanos podría estar problematizando el cambio climático en relación con el ser humano.Los determinantes de salud generados por el cambio climático limitarían potencialmente las capacidades humanas, entendidas por Martha Nussbaum como manifestación de la libertad humana para ser y hacer.También se menciona el pensamiento de Hans Jonas en relación con la necesidad de tener temor por las conse-cuencias de una falta de acción. Se concluye, finalmente, que los profundos cambios contextuales asociados al cambio climático deberían promover la pregunta acerca de sus potenciales efectos a nivel del neurodesarrollo de los niños que viven en zonas de desastres asociados a este. Simultáneamente, en una perspectiva donde convergen la bioética y la neuroética, el cambio climático resaltaría la responsabilidad que los seres humanos individual y colectivamente tenemos en la construcción de las condiciones presentes y futuras del desarrollo infantil, y particularmente cuando este se da en condiciones de pobreza.

  12. Normalization Strategies for Enhancing Spatio-Temporal Analysis of Social Media Responses during Extreme Events: A Case Study based on Analysis of Four Extreme Events using Socio-Environmental Data Explorer (SEDE)

    Science.gov (United States)

    Ajayakumar, J.; Shook, E.; Turner, V. K.

    2017-10-01

    With social media becoming increasingly location-based, there has been a greater push from researchers across various domains including social science, public health, and disaster management, to tap in the spatial, temporal, and textual data available from these sources to analyze public response during extreme events such as an epidemic outbreak or a natural disaster. Studies based on demographics and other socio-economic factors suggests that social media data could be highly skewed based on the variations of population density with respect to place. To capture the spatio-temporal variations in public response during extreme events we have developed the Socio-Environmental Data Explorer (SEDE). SEDE collects and integrates social media, news and environmental data to support exploration and assessment of public response to extreme events. For this study, using SEDE, we conduct spatio-temporal social media response analysis on four major extreme events in the United States including the "North American storm complex" in December 2015, the "snowstorm Jonas" in January 2016, the "West Virginia floods" in June 2016, and the "Hurricane Matthew" in October 2016. Analysis is conducted on geo-tagged social media data from Twitter and warnings from the storm events database provided by National Centers For Environmental Information (NCEI) for analysis. Results demonstrate that, to support complex social media analyses, spatial and population-based normalization and filtering is necessary. The implications of these results suggests that, while developing software solutions to support analysis of non-conventional data sources such as social media, it is quintessential to identify the inherent biases associated with the data sources, and adapt techniques and enhance capabilities to mitigate the bias. The normalization strategies that we have developed and incorporated to SEDE will be helpful in reducing the population bias associated with social media data and will be useful

  13. Celebrating the tenth conference session

    International Nuclear Information System (INIS)

    1966-01-01

    Full text: This number of the Bulletin appears during a month when the tenth regular session of the Agency's General Conference is being held. It is fitting that among the special arrangements made to give added significance to such an historical landmark should be an opening address by Herr Franz Jonas, Federal President of the host country, Austria. The Festsaal of the Kongresszentrum, in the Hofburg, has now been the centre for every annual session held in Austria, except the first. On that occasion, recorded in the photograph on the cover, the Konzerthaus was made available. A commemorative series of talks dealing with topics of particular interest in the international development of the peaceful uses of atomic energy, delivered by scientists of world distinction was another idea which will add much profound thought to the records of nuclear energy. Under the chairmanship of Professor L.C. Prado, with Dr. W.B. Lewis as Moderator, the subjects chosen by the participants were : The Impact of Atomic Energy in our Society - Sir John Cockcroft; Nuclear Power Systems and their Technical Potentialities - Prof. Alexandre Leipunski; The Commercial Future of Nuclear Power - Dr. William Webster; Nuclear Science in Life Sciences - Dr. A.R. Gopal-Ayengar; Fundamental Research in Atomic Energy Centres - Prof. Louis Neel. These speeches will be reproduced in full in the Agency's Atomic Energy Review. The pages of this issue of the Bulletin are intended to give indications of the stage which the Agency has now reached in some, but by no means all, of its activities in promoting the techniques of atomic energy for the benefit of mankind. (author)

  14. Modeling the thermodynamics of QCD

    Energy Technology Data Exchange (ETDEWEB)

    Hell, Thomas

    2010-07-26

    Strongly interacting (QCD) matter is expected to exhibit a multifaceted phase structure: a hadron gas at low temperatures, a quark-gluon plasma at very high temperatures, nuclear matter in the low-temperature and high-density region, color superconductors at asymptotically high densities. Most of the conjectured phases cannot yet be scrutinized by experiments. Much of the present picture - particularly concerning the intermediate temperature and density area of the phase diagram of QCD matter - is based on model calculations. Further insights come from Lattice-QCD computations. The present thesis elaborates a nonlocal covariant extension of the Nambu and Jona-Lasinio (NJL) model with built-in constraints from the running coupling of QCD at high-momentum and instanton physics at low-momentum scales. We present this model for two and three quark flavors (in the latter case paying particular attention to the axial anomaly). At finite temperatures and densities, gluon dynamics is incorporated through a gluonic background field, expressed in terms of the Polyakov loop (P). The thermodynamics of this nonlocal PNJL model accounts for both chiral and deconfinement transitions. We obtain results in mean-field approximation and beyond, including additional pionic and kaonic contributions to the chiral condensate, the pressure and other thermodynamic quantities. Finally, the nonlocal PNJL model is applied to the finite-density region of the QCD phase diagram; for three quark flavors we investigate, in particular, the dependence of the critical point appearing in the models on the axial anomaly. The thesis closes with a derivation of the nonlocal PNJL model from first principles of QCD. (orig.)

  15. Competing effective interactions of Dirac electrons in the Spin–Fermion system

    International Nuclear Information System (INIS)

    Marino, E.C.; Nunes, Lizardo H.C.M.

    2014-01-01

    Recently discovered advanced materials, such as heavy fermions, frequently exhibit a rich phase diagram suggesting the presence of different competing interactions. A unified description of the origin of these multiple interactions, albeit very important for the comprehension of such materials is, in general not available. It would be therefore very useful to have a simple model where the common source of different interactions could be possibly traced back. In this work we consider a system consisting in a set of localized spins on a square lattice with antiferromagnetic nearest neighbors interactions and itinerant electrons, which are assumed to be Dirac-like and interact with the localized spins through a Kondo magnetic interaction. This system is conveniently described by the Spin–Fermion model, which we use in order to determine the effective interactions among the itinerant electrons. By integrating out the localized degrees of freedom we obtain a set of different interactions, which includes: a BCS-like superconducting term, a Nambu–Jona-Lasinio-like, excitonic term and a spin–spin magnetic term. The resulting phase diagram is investigated by evaluation of the mean-field free-energy as a function of the relevant order parameters. This shows the competition of the above interactions, depending on the temperature, chemical potential and coupling constants. -- Highlights: •Antiferromagnetic Heisenberg–Kondo lattice model with itinerant Dirac fermions. •Integrating out the spins generates competing interactions: BCS-like, excitonic and magnetic. •Novel mechanism of superconductivity from magnetic interactions between the spins and electrons. •Dome-shaped dependence of the temperature on the chemical potential in agreement with pnictides

  16. Artificial Reefs in Motion: Legacy of changes and degradation at the Redbird Reef Site

    Science.gov (United States)

    Trembanis, A. C.; DuVal, C.; Peter, B.

    2016-12-01

    Artificial reefs are used for a variety of purposes at sites throughout the U.S. and around the globe, yet little, if any, long-term monitoring has been conducted with the goal of understanding inter-annual changes to the emplaced structures. Throughout the U.S. Mid-Atlantic region, several programs utilized retired subway cars as disposal structures to form artificial reefs. One such site, known as site 11, or "Redbird Reef", is located off the coast of Delaware and was at one time home to 997 former NYC subway cars. Opportunistic sonar surveys at the site have been conducted between 2008 and 2016 providing one of the most extensive and repeated mapping studies for this type of reef. Previous studies conducted by our group at the site have focused on understanding wave orbital ripple dynamics and scour patterns. In this present study, we analyze the changes apparent at the site itself, focused on the storm-response dynamics of the subway cars. Results have shown that Superstorm Sandy in 2012 produced dramatic changes to the reef structures resulting in the total or partial destruction of eight subway cars within a small (.45 x .2km) portion of the reef site. Winter Storm Jonas in 2016 resulted in the destruction of fewer cars, but rotated a previously static 47m long Navy barge nearly 60 degrees. Once destroyed or collapsed by waves the subway cars go from providing positive structural relief and thus beneficial habitat above the surrounding seabed to being reduced to scattered low relief marine debris. A once popular consideration for reef material, the event and inter-annual decay of subway cars as observed at the Redbird reef provides both a stark indication of the power of storm dynamics on the inner-shelf and a cautionary tale with regards to the selection of seabed reef material.

  17. Effective Field Theories for Hot and Dense Matter

    Directory of Open Access Journals (Sweden)

    Blaschke D.

    2010-10-01

    Full Text Available The lecture is divided in two parts. The first one deals with an introduction to the physics of hot, dense many-particle systems in quantum field theory [1, 2]. The basics of the path integral approach to the partition function are explained for the example of chiral quark models. The QCD phase diagram is discussed in the meanfield approximation while QCD bound states in the medium are treated in the rainbow-ladder approximation (Gaussian fluctuations. Special emphasis is devoted to the discussion of the Mott effect, i.e. the transition of bound states to unbound, but resonant scattering states in the continnum under the influence of compression and heating of the system. Three examples are given: (1 the QCD model phase diagram with chiral symmetry ¨ restoration and color superconductivity [3], (2 the Schrodinger equation for heavy-quarkonia [4], and (2 Pions [5] as well as Kaons and D-mesons in the finite-temperature Bethe-Salpeter equation [6]. We discuss recent applications of this quantum field theoretical approach to hot and dense quark matter for a description of anomalous J/ψ supression in heavy-ion collisions [7] and for the structure and cooling of compact stars with quark matter interiors [8]. The second part provides a detailed introduction to the Polyakov-loop Nambu–Jona-Lasinio model [9] for thermodynamics and mesonic correlations [10] in the phase diagram of quark matter. Important relationships of low-energy QCD like the Gell-Mann–Oakes–Renner relation are generalized to finite temperatures. The effect of including the coupling to the Polyakov-loop potential on the phase diagram and mesonic correlations is discussed. An outlook is given to effects of nonlocality of the interactions [11] and of mesonic correlations in the medium [12] which go beyond the meanfield description.

  18. Neutral and charged scalar mesons, pseudoscalar mesons, and diquarks in magnetic fields

    Science.gov (United States)

    Liu, Hao; Wang, Xinyang; Yu, Lang; Huang, Mei

    2018-04-01

    We investigate both (pseudo)scalar mesons and diquarks in the presence of external magnetic field in the framework of the two-flavored Nambu-Jona-Lasinio (NJL) model, where mesons and diquarks are constructed by infinite sum of quark-loop chains by using random phase approximation. The polarization function of the quark-loop is calculated to the leading order of 1 /Nc expansion by taking the quark propagator in the Landau level representation. We systematically investigate the masses behaviors of scalar σ meson, neutral and charged pions as well as the scalar diquarks, with respect to the magnetic field strength at finite temperature and chemical potential. It is shown that the numerical results of both neutral and charged pions are consistent with the lattice QCD simulations. The mass of the charge neutral pion keeps almost a constant under the magnetic field, which is preserved by the remnant symmetry of QCD ×QED in the vacuum. The mass of the charge neutral scalar σ is around two times quark mass and increases with the magnetic field due to the magnetic catalysis effect, which is an typical example showing that the polarized internal quark structure cannot be neglected when we consider the meson properties under magnetic field. For the charged particles, the one quark-antiquark loop contribution to the charged π± increases essentially with the increase of magnetic fields due to the magnetic catalysis of the polarized quarks. However, the one quark-quark loop contribution to the scalar diquark mass is negative comparing with the point-particle result and the loop effect is small.

  19. Ethics Beyond Finitude: Responsibility towards Future Generations and Nuclear Waste Management

    Energy Technology Data Exchange (ETDEWEB)

    Loefquist, Lars

    2008-05-15

    This dissertation has three aims: 1. To evaluate several ethical theories about responsibility towards future generations. 2. To construct a theory about responsibility towards future generations. 3. To carry out an ethical evaluation of different nuclear waste management methods. Five theories are evaluated with the help of evaluative criteria, primarily: A theory must provide future generations with some independent moral status. A theory should acknowledge moral pluralism. A theory should provide some normative claims about real-world problems. Derek Parfit's theory provides future generations with full moral status. But it is incompatible with moral pluralism, and does not provide reasonable normative claims about real-world problems. Brian Barry's theory provides such claims and a useful idea about risk management, but it does not provide an argument why future generations ought to exist. Avner de-Shalit's theory explains why they ought to exist; however, his theory can not easily explain why we ought to care for other people than those in our own community. Emmanuel Agius' theory gives an ontological explanation for mankind's unity, but reduces conflicts of interests to a common good. Finally, Hans Jonas' theory shifts the focus from the situation of future generations to the preconditions of human life generally. However, his theory presupposes a specific ontology, which might be unable to motivate people to act. The concluding chapters describe a narrative theory of responsibility. It claims that we should comprehend ourselves as parts of the common story of mankind and that we ought to provide future generations with equal opportunities. This implies that we should avoid transferring risks and focus on reducing the long-term risks associated with the nuclear waste

  20. Universal sequence map (USM of arbitrary discrete sequences

    Directory of Open Access Journals (Sweden)

    Almeida Jonas S

    2002-02-01

    Full Text Available Abstract Background For over a decade the idea of representing biological sequences in a continuous coordinate space has maintained its appeal but not been fully realized. The basic idea is that any sequence of symbols may define trajectories in the continuous space conserving all its statistical properties. Ideally, such a representation would allow scale independent sequence analysis – without the context of fixed memory length. A simple example would consist on being able to infer the homology between two sequences solely by comparing the coordinates of any two homologous units. Results We have successfully identified such an iterative function for bijective mappingψ of discrete sequences into objects of continuous state space that enable scale-independent sequence analysis. The technique, named Universal Sequence Mapping (USM, is applicable to sequences with an arbitrary length and arbitrary number of unique units and generates a representation where map distance estimates sequence similarity. The novel USM procedure is based on earlier work by these and other authors on the properties of Chaos Game Representation (CGR. The latter enables the representation of 4 unit type sequences (like DNA as an order free Markov Chain transition table. The properties of USM are illustrated with test data and can be verified for other data by using the accompanying web-based tool:http://bioinformatics.musc.edu/~jonas/usm/. Conclusions USM is shown to enable a statistical mechanics approach to sequence analysis. The scale independent representation frees sequence analysis from the need to assume a memory length in the investigation of syntactic rules.