WorldWideScience

Sample records for circulatory support systems

  1. Biological evaluation of mechanical circulatory support systems in calves

    NARCIS (Netherlands)

    Rakhorst, G; VanDerMeer, J; Kik, C; Mihaylov, D; Havlik, P; Trinkl, J; Monties, [No Value

    1996-01-01

    Data from animal experiments with mechanical circulatory support systems (MCSS) performed in Groningen and Marseille over the past years were used to obtain normal values of hematological, coagulation, rheological and blood chemistry parameters in calves. These parameters were divided between two gr

  2. Long-term Mechanical Circulatory Support System reliability recommendation by the National Clinical Trial Initiative subcommittee.

    Science.gov (United States)

    Lee, James

    2009-01-01

    The Long-Term Mechanical Circulatory Support (MCS) System Reliability Recommendation was published in the American Society for Artificial Internal Organs (ASAIO) Journal and the Annals of Thoracic Surgery in 1998. At that time, it was stated that the document would be periodically reviewed to assess its timeliness and appropriateness within 5 years. Given the wealth of clinical experience in MCS systems, a new recommendation has been drafted by consensus of a group of representatives from the medical community, academia, industry, and government. The new recommendation describes a reliability test methodology and provides detailed reliability recommendations. In addition, the new recommendation provides additional information and clinical data in appendices that are intended to assist the reliability test engineer in the development of a reliability test that is expected to give improved predictions of clinical reliability compared with past test methods. The appendices are available for download at the ASAIO journal web site at www.asaiojournal.com.

  3. The artificial ventricle: A conceptual design for a novel mechanical circulatory support system.

    Science.gov (United States)

    Sherif, Hisham M F

    2009-01-01

    We describe a novel design for a new mechanical circulatory support pump which can be utilized for single or biventricular support in a completely internal configuration. The device has a long projected service life, a totally implantable, readily available and off-the-shelf energy source. The proposed device is a pulsatile, positive-displacement blood pump composed of a conically-shaped compliance chamber, constructed of a biocompatible material and attached to two bioprosthetic valves (an inlet valve and an outlet valve), surrounded by radially-arranged contractile elements, made of an electro-active polymer and connected to a common stimulating electrode connected to an implantable permanent pacemaker. The entire assembly is housed in a hermetically sealed biologically inert shell. The energy output from the pacemaker will cause the deformation of the contractile elements and thus compression of the compliance chamber, effecting ejection of the blood through the outlet valve. Based on a design emulating the natural anatomic configuration, the device shall be able to provide clinically significant mechanical assistance and/or replacement of the native heart function and thus a means of supporting the failing ventricle(s) or replacing the failing heart for an extended period of time. The proposed design offers a new pulsatile, positive displacement mechanical circulatory support or replacement for one or both ventricles, is completely implantable, is composed of readily available materials, has minimal energy requirements and an extended service life on internal power supply.

  4. State of the Art of Mechanical Circulatory Support

    OpenAIRE

    Mallidi, Hari R.; Anand, Jatin; Cohn, William E.

    2014-01-01

    Mechanical circulatory support of the failing heart has become an important means of treating end-stage heart disease. This rapidly growing therapeutic field has produced impressive clinical outcomes and has great potential to help thousands of otherwise terminal patients worldwide. In this review, we examine the state of the art of mechanical circulatory support: current practice, totally implantable systems of the future, evolving biventricular support mechanisms, the potential for myocardi...

  5. REMOTE MONITORING OF PATIENTS WITH LONG-TERM MECHATRONIC CIRCULATORY SUPPORT SYSTEM

    Directory of Open Access Journals (Sweden)

    A. V. Adaskin

    2016-01-01

    Full Text Available The article describes the technology of remote patient monitoring and the parameters of circulatory assist device AVK-N as well as the advantages of said technology to improve the efficiency of personalized medicine in diagnosis and treatment of patients with AVK-N in the postoperative period. Authors show the capabilities of remote monitoring technology to determine the location of the patient by satellite navigation in the case of emergency call for medical and technical services, and present the structure and modes of the displayed information for mobile devices and Web-server. Doctor-patient interaction based on remote monitoring technology via mobile/ satellite/wired Internet is also shown. 

  6. MECHANICAL CIRCULATORY SUPPORT: PROBLEMS, SOLUTIONS AND NEW DIRECTIONS

    Directory of Open Access Journals (Sweden)

    G. P. Itkin

    2014-01-01

    Full Text Available The article brings up for the discussion main problems standing in the way of development of the mechanical circulatory support (MCS technology. We give a short historical overview of the development of this technology in our country. Classifi cation of MCS systems for medical indications is given; methods and techniques for short-term and long-term therapy with MCS systems are considered. Main directions of the development of MCS methods are discussed. Using the example of personal experience the methods of design and research of MCS systems are investigated.

  7. Outline of the International Organization for Standardization Standard for Circulatory Support Devices (ISO 14708-5).

    Science.gov (United States)

    Imachi, Kou; Mussivand, Tofy

    2010-09-01

    The rapid progress of artificial heart and circulatory support devices enables us to apply them to severe heart failure patients. Many types of circulatory support devices have been developed in the United States, Europe, and Japan. This situation urged the establishment of an International Organization for Standardization (ISO) Standard for the circulatory support devices. A new work, "Cardiac Ventricular Assist Devices," was proposed to the ISO/TC150/SC6 (TC150: Technical Committee of Implants for Surgery, SC6: Sub-committee of Active Implants) in 2000, and the work was finalized for publication at a 2009 meeting of the ISO/TC150 in Kyoto. In this article, the authors would like to introduce the ISO system and the outline of the ISO Standard for Circulatory Support Devices.

  8. MECHANISMS OF RIGHT VENTRICULAR FAILURE AND BIVENTRICULAR MECHANICAL CIRCULATORY SUPPORT

    Directory of Open Access Journals (Sweden)

    G. P. Itkin

    2013-01-01

    Full Text Available The paper presents a review of the problems of mechanical circulatory support with left ventricular bypass in total cardiac failure. Dysfunction of right ventricular defines the high mortality on left ventricular device. One of the effective methods for solving this problem is the use of right ventricular assisted devices. There are considered of the basic physiological mechanisms of interaction between the right and left ventricles of the heart, affecting on the function of the right heart. Shows the need to assess right ventricular function before deciding on mechanical circulatory support. Provides examples of the estimation the predictors of the right ventricular failure. The basic methods and devices of biventricular circulatory support were con- sidered. 

  9. The European Registry for Patients with Mechanical Circulatory Support (EUROMACS)

    DEFF Research Database (Denmark)

    de By, Theo M M H; Mohacsi, Paul; Gummert, Jan

    2015-01-01

    other founding international members. It aims to promote scientific research to improve care of end-stage heart failure patients with ventricular assist device or a total artificial heart as long-term mechanical circulatory support. Likewise, the organization aims to provide and maintain a registry...

  10. Current Status of Mechanical Circulatory Support: A Systematic Review

    Directory of Open Access Journals (Sweden)

    Kyriakos Spiliopoulos

    2012-01-01

    Full Text Available Heart failure is a major public health problem and its management requires a significant amount of health care resources. Even with administration of the best available medical treatment, the mortality associated with the disease remains high. As therapeutical strategies for heart failure have been refined, the number of patients suffering from the disease has expanded dramatically. Although heart transplantation still represents the gold standard therapeutical approach, the implantation of mechanical circulatory support devices (MCSDs evolved to a well-established management for this disease. The limited applicability of heart transplantation caused by a shortage of donor organs and the concurrent expand of the patient population with end-stage heart failure led to a considerable utilization of MCSDs. This paper outlines the current status of mechanical circulatory support.

  11. A note on circulatory systems: Old and new results

    DEFF Research Database (Denmark)

    Kliem, Wolfhard; Pommer, Christian

    2017-01-01

    repeat this result in order to emphasize that the criterion is sufficient but not necessary for stability. Afterwards we concentrate on circulatory systems with purely imaginary eigenvalues and investigate the influence of indefinite damping. Finally the possibility of stabilizing circulatory systems...

  12. PROSPECTS OF DISK PUMP FOR MECHANICAL CIRCULATORY SUPPORT IN CARDIAC SURGERY (REVIEW

    Directory of Open Access Journals (Sweden)

    A. M. Chernyavskiy

    2016-01-01

    Full Text Available The need of circulatory support systems in the treatment of chronic heart failure is increasing constantly, as 20% of the patients on the waiting list die every year. Despite the great need for mechanical heart support systems, the use of available systems is limited by its expensiveness. In addition, there is no one system that is 100% responsible to all medical and technical requirements and that would be completely safe for patient. Therefore, further research in the field of circulatory support systems considering health and technical requirements is relevant. One of the new directions in the study are disc pumps of viscous friction for liquid transporting, based on the Tesla pump principle. The operation principle of such pumps is based on the phenomenon of the boundary layer which is formed on the disk rotating in a fluid. There are experimental studies of models with different variants of the rotor suspension, various forms and numbers of the disks, forms of the pump housing. However, none of the above samples was brought to clinical trials. Furthermore, despite the potential of that model there have been no pumps of similar type used so far in circulatory support systems. Published data provide a basis for further development and testing of the pump model and allow hoping for leveling a number of significant shortcomings of modern left ventricular bypass systems

  13. Mechanical circulatory support in cardiogenic shock – what every interventional cardiologist should know

    Science.gov (United States)

    Pres, Damian; Przybylski, Roman; Pacholewicz, Jerzy; Poloński, Lech; Zembala, Marian; Gąsior, Mariusz

    2014-01-01

    Cardiogenic shock (CS) remains the main cause of death in patients with myocardial infarction. Conservative treatment alone does not sufficiently improve prognosis. Mortality in CS can only be significantly reduced with revascularization, both surgical and percutaneous. However some patients present with haemodynamic instability despite optimal medical treatment and complete revascularization, resulting in very high mortality rates. These patients require the implementation of mechanical circulatory support in order to increase systemic blood flow, protect against organ hypoperfusion and protect the myocardium through a decrease in oxygen consumption. In contemporary interventional cardiology it seems that every operator should be aware of all available mechanical circulatory support methods for their patients. This article aims to present the current state of knowledge and technical possibilities in this area. PMID:25489306

  14. [The diseases of circulatory system in employees of railway transport].

    Science.gov (United States)

    Molodtsov, R N; Shemetova, G N

    2013-01-01

    The article presents the epidemiologic and medical social aspects of diseases of circulatory system in employees of railway transport in 2000-2010 exemplified by Privolzhskiy railroad. The established tendencies in prevalence of pathology of cardio-vascular system in railroad workers makes the issues of practical implementation of priority of prevention in the organization of medical care to this group of patients to come to foreground. The main directions for complex prevention of diseases of circulatory system in employees of railway transport are presented.

  15. [Design of a testing system for antithrombotic pressure circulatory equipment].

    Science.gov (United States)

    Zhou, Xun; Cui, Haipo; Shang, Kun; Li, Zhelong; Cheng, Enqing

    2014-02-01

    A new type of testing system used for antithrombotic pressure circulatory equipment has been developed, which realized a new method for the calibration of pressure sensor. Multi-path control and acquisition functions are achieved by this method based on human-computer interaction testing system. The precision of pressure sensor is ob tained by polynomial fitting for each test point using linear interpolation method. The result showed that the precision test of pressure sensor could be realized easily and efficiently, using the developed testing system, and the parameters of pressure sensor could be calibrated effectively, so that it could be accurately used in the antithrombotic pressure circulatory equipment. The developed testing system has a prosperous future in the aspects of promotion and application.

  16. Towards a Fast Dynamic Model of the Human Circulatory System

    Science.gov (United States)

    Kaplan, Carolyn; Green, Melissa; Boris, Jay; Oran, Elaine

    2011-11-01

    We describe a model for systems-level transport in the human circulatory system that is based on a set of equations for a one-dimensional unsteady elastic pipe flow circuit. The system is collapsed from three spatial dimensions and time to one spatial dimension and time by assuming axisymmetric vessel geometry and a parabolic velocity profile across the cylindrical vessels. To drive the fluid, the contractions of a beating heart are modeled as periodic area changes of the elastic vessels. Two different models are compared, both including and neglecting fluid acceleration. Time-resolved distributions of pressure, velocity and area compare reasonably well with reference data. Increasing the rigidity of the vasculature is found to increase peak arterial pressures on the order of ten percent, and including a distributed vascular contraction to model distributed skeletal muscle contractions monotonically increases time-averaged blood flow in the veins, consistent with human physiological response. The circulatory system model presented here simulates the circulatory system on the order of one hundred times faster than real-time; that is, we can compute thousands of heartbeats per minute of CPU time.

  17. [Caffeine and adaptive changes in the circulatory system during pregnancy].

    Science.gov (United States)

    Cendrowska-Pinkosz, Monika; Dworzański, Wojciech; Krauze, Magdalena; Burdan, Franciszek

    2017-01-23

    Adaptive physiological changes that occur in pregnant women can fluctuate with the intake of substances with proven, adverse biological effect on the body. Due to the fact that caffeine is one of the most chronically used xenobiotics, the impact of consuming caffeine on adaptive processes in the circulatory system of a pregnant women required a research. Many researchers emphasise its negative effect on the circulatory system of the mother and her offspring. However, in spite of years of observation, there is no clear answer to what extent dose or in what period of time the caffeine modulates the adaptive processes during pregnancy. Because of the potential risk the supply of caffeine during pregnancy should be subjected to considerable restrictions.

  18. Towards a Fast Dynamic Model of the Human Circulatory System

    Science.gov (United States)

    2011-10-06

    4.5m for the pulmonary vascular tree. According to Guyton & Hall (2000), about 5 L is considered normal for an adult human, and the area distribution...decreases further, and even falls below the equilibrium pressure. Guyton & Hall (2000) reports that normal mean pressures are 100 mmHg in the arteries, 20...the order of 100 times faster than realtime. Five liters is considered a normal volume for an adult human circulatory system ( Guyton & Hall, 2000

  19. Modeling the heart and the circulatory system

    CERN Document Server

    2015-01-01

    The book comprises contributions by some of the most respected scientists in the field of mathematical modeling and numerical simulation of the human cardiocirculatory system. The contributions cover a wide range of topics, from the preprocessing of clinical data to the development of mathematical equations, their numerical solution, and both in-vivo and in-vitro validation. They discuss the flow in the systemic arterial tree and the complex electro-fluid-mechanical coupling in the human heart. Many examples of patient-specific simulations are presented. This book is addressed to all scientists interested in the mathematical modeling and numerical simulation of the human cardiocirculatory system.

  20. A Simulink model for the human circulatory system.

    Science.gov (United States)

    Wabel, P; Leonhardt, S

    1998-01-01

    This paper presents the mathematical simulation of the human circulatory system. The model is based on the former work of Coleman and co-workers and has been redesigned for simulation with the Matlab toolbox "Simulink". It includes the heart and the peripheral circulation, the respiratory system, the kidneys and the major neural and hormonal control mechanisms, which are necessary for maintaining homeostasis. The model contains more than 30 blocks with over 200 physiological variables, which can be accessed and plotted during the simulation.

  1. Computational Hemodynamic Simulation of Human Circulatory System under Altered Gravity

    Science.gov (United States)

    Kim. Chang Sung; Kiris, Cetin; Kwak, Dochan

    2003-01-01

    A computational hemodynamics approach is presented to simulate the blood flow through the human circulatory system under altered gravity conditions. Numerical techniques relevant to hemodynamics issues are introduced to non-Newtonian modeling for flow characteristics governed by red blood cells, distensible wall motion due to the heart pulse, and capillary bed modeling for outflow boundary conditions. Gravitational body force terms are added to the Navier-Stokes equations to study the effects of gravity on internal flows. Six-type gravity benchmark problems are originally presented to provide the fundamental understanding of gravitational effects on the human circulatory system. For code validation, computed results are compared with steady and unsteady experimental data for non-Newtonian flows in a carotid bifurcation model and a curved circular tube, respectively. This computational approach is then applied to the blood circulation in the human brain as a target problem. A three-dimensional, idealized Circle of Willis configuration is developed with minor arteries truncated based on anatomical data. Demonstrated is not only the mechanism of the collateral circulation but also the effects of gravity on the distensible wall motion and resultant flow patterns.

  2. Use of Short-term Circulatory Support as a Bridge in Pediatric Heart Transplantation

    Directory of Open Access Journals (Sweden)

    Luiz Fernando Canêo

    2015-01-01

    Full Text Available Background: Heart transplantation is considered the gold standard therapy for the advanced heart failure, but donor shortage, especially in pediatric patients, is the main limitation for this procedure, so most sick patients die while waiting for the procedure. Objective: To evaluate the use of short-term circulatory support as a bridge to transplantation in end-stage cardiomyopathy. Methods: Retrospective clinical study. Between January 2011 and December 2013, 40 patients with cardiomyopathy were admitted in our Pediatric Intensive Care Unit, with a mean age of 4.5 years. Twenty patients evolved during hospitalization with clinical deterioration and were classified as Intermacs 1 and 2. One patient died within 24 hours and 19 could be stabilized and were listed. They were divided into 2 groups: A, clinical support alone and B, implantation of short-term circulatory support as bridge to transplantation additionally to clinical therapy. Results: We used short-term mechanical circulatory support as a bridge to transplantation in 9. In group A (n=10, eight died waiting and 2 patients (20% were transplanted, but none was discharged. In group B (n=9, 6 patients (66.7% were transplanted and three were discharged.The mean support time was 21,8 days (6 to 984h. The mean transplant waiting list time was 33,8 days. Renal failure and sepsis were the main complication and causeof death in group A while neurologic complications were more prevalent en group B. Conclusion: Mechanical circulatory support increases survival on the pediatric heart transplantation waiting list in patients classified as Intermacs 1 and 2.

  3. Mechanical circulatory support for patients with peripartum cardiomyopathy.

    Science.gov (United States)

    Lueck, Sabrina; Sindermann, Juergen; Martens, Sven; Scherer, Mirela

    2016-09-01

    Peripartum cardiomyopathy (PPCM) challenges different disciplines including gynecologists, cardiologists and cardiac surgeons. It is a severe cardiac failure occurring at the end of pregnancy or within the first months after delivery. Urgent intervention is necessary to stabilize hemodynamics with appropriate medication and mechanical assist support. Data of 4 patients with PPCM at a mean age of 28.2 years were analyzed retrospectively. Echocardiography was used to evaluate cardiac function. Despite varying courses of PPCM all women received left ventricular assist devices (LVAD) since their hemodynamics could not be stabilized by medical treatment. Mean gestational week at delivery was 31.5 ± 4.9. Left ventricular ejection fractions of all patients were severely impaired (17.8 ± 3.5 %) before LVAD implantations. After long-term mechanical support (282 and 417 days, respectively) 2 patients were successfully transplanted. Two other females could be weaned from LVAD therapy after 944 and 612 days, respectively. LVAD explanations were performed according to a standardized weaning protocol. Myocardial recovery was confirmed by regular echocardiography, spiroergometry and right heart catheterization. Mechanical assist device support is a surgical strategy either as bridge to transplantation or as bridge to recovery for patients with PPCM.

  4. Mechanical Circulatory Support Devices for Pediatric Patients With Congenital Heart Disease.

    Science.gov (United States)

    Chopski, Steven G; Moskowitz, William B; Stevens, Randy M; Throckmorton, Amy L

    2017-01-01

    The use of mechanical circulatory support (MCS) devices is a viable therapeutic treatment option for patients with congestive heart failure. Ventricular assist devices, cavopulmonary assist devices, and total artificial heart pumps continue to gain acceptance as viable treatment strategies for both adults and pediatric patients as bridge-to-transplant, bridge-to-recovery, and longer-term circulatory support alternatives. We present a review of the current and future MCS devices for patients having congenital heart disease (CHD) with biventricular or univentricular circulations. Several devices that are specifically designed for patients with complex CHD are in the development pipeline undergoing rigorous animal testing as readiness experiments in preparation for future clinical trials. These advances in the development of new blood pumps for patients with CHD will address a significant unmet clinical need, as well as generally improve innovation of the current state of the art in MCS technology.

  5. Bridge to recovery in two cases of dilated cardiomyopathy after long-term mechanical circulatory support

    OpenAIRE

    Pacholewicz, Jerzy; Zakliczyński, Michał; Kowalik, Violetta; Nadziakiewicz, Paweł; Kowalski, Oskar; Kalarus, Zbigniew; Zembala, Marian

    2014-01-01

    Ventricular assist devices (VADs) have become an established therapeutic option for patients with end-stage heart failure. Achieving the potential for recovery of native heart function using VADs is an established form of treatment in a selected group of patients with HF. We report two cases of VAD patients with different types of pump used for mechanical circulatory support, a continuous flow pump (Heart-Ware®) and a pulsatile pump (POLVAD MEV®), which allow regeneration of the native heart....

  6. FEATURES OF LONG-TERM MECHANICAL CIRCULATORY SUPPORT WITH CONTINUOUS-FLOW PUMP

    Directory of Open Access Journals (Sweden)

    G. P. Itkin

    2012-01-01

    Full Text Available In a review of the comparative analysis of methods and tools for long-term mechanical circulatory support with continuous flow and pulsatile flow implantable pumps. Particular attention is paid to the choice of the optimal modes of the operation of pumps based on the physical principles of the interaction between a the steady flow of blood to the pulsatile mechanics of the heart chambers. 

  7. Hemocompatibility of Axial Versus Centrifugal Pump Technology in Mechanical Circulatory Support Devices.

    Science.gov (United States)

    Schibilsky, David; Lenglinger, Matthias; Avci-Adali, Meltem; Haller, Christoph; Walker, Tobias; Wendel, Hans Peter; Schlensak, Christian

    2015-08-01

    The hemocompatible properties of rotary blood pumps commonly used in mechanical circulatory support (MCS) are widely unknown regarding specific biocompatibility profiles of different pump technologies. Therefore, we analyzed the hemocompatibility indicating markers of an axial flow and a magnetically levitated centrifugal device within an in vitro mock loop. The HeartMate II (HM II; n = 3) device and a CentriMag (CM; n = 3) adult pump were investigated in a human whole blood mock loop for 360 min using the MCS devices as a driving component. Blood samples were analyzed by enzyme-linked immunosorbent assay for markers of coagulation, complement system, and inflammatory response. There was a time-dependent activation of the coagulation (thrombin-antithrombin complexes [TAT]), complement (SC5b-9), and inflammation system (polymorphonuclear [PMN] elastase) in both groups. The mean value of TAT (CM: 4.0 μg/L vs. 29.4 μg/L, P centrifugal CM device showed significantly lower activation of coagulation and inflammation than that of the HM II axial flow pump. Both HM II and CM have demonstrated an acceptable hemocompatibility profile in patients. However, there is a great opportunity to gain a clinical benefit by developing techniques to lower the blood surface interaction within both pump technologies and a magnetically levitated centrifugal pump design might be superior.

  8. Von Willebrand factor in patients on mechanical circulatory support – a double-edged sword between bleeding and thrombosis

    OpenAIRE

    Hudzik, Bartosz; Kaczmarski, Jacek; Pacholewicz, Jerzy; Zakliczynski, Michal; Gasior, Mariusz; Zembala, Marian

    2015-01-01

    Mechanical circulatory support (MCS) is an umbrella term describing the various technologies used in both short- and long-term management of patients with either end-stage chronic heart failure (HF) or acute HF. Most often, MCS has emerged as a bridge to transplantation, but more recently it is also used as a destination therapy. Mechanical circulatory support includes left ventricular assist device (LVAD) or bi-ventricular assist device (Bi-VAD). Currently, 2- to 3-year survival in carefully...

  9. Adhesion Molecules: Master Controllers of the Circulatory System.

    Science.gov (United States)

    Schmidt, Eric P; Kuebler, Wolfgang M; Lee, Warren L; Downey, Gregory P

    2016-03-15

    This manuscript will review our current understanding of cellular adhesion molecules (CAMs) relevant to the circulatory system, their physiological role in control of vascular homeostasis, innate and adaptive immune responses, and their importance in pathophysiological (disease) processes such as acute lung injury, atherosclerosis, and pulmonary hypertension. This is a complex and rapidly changing area of research that is incompletely understood. By design, we will begin with a brief overview of the structure and classification of the major groups of adhesion molecules and their physiological functions including cellular adhesion and signaling. The role of specific CAMs in the process of platelet aggregation and hemostasis and leukocyte adhesion and transendothelial migration will be reviewed as examples of the complex and cooperative interplay between CAMs during physiological and pathophysiological processes. The role of the endothelial glycocalyx and the glycobiology of this complex system related to inflammatory states such as sepsis will be reviewed. We will then focus on the role of adhesion molecules in the pathogenesis of specific disease processes involving the lungs and cardiovascular system. The potential of targeting adhesion molecules in the treatment of immune and inflammatory diseases will be highlighted in the relevant sections throughout the manuscript.

  10. Endoglin regulates mural cell adhesion in the circulatory system.

    Science.gov (United States)

    Rossi, Elisa; Smadja, David M; Boscolo, Elisa; Langa, Carmen; Arevalo, Miguel A; Pericacho, Miguel; Gamella-Pozuelo, Luis; Kauskot, Alexandre; Botella, Luisa M; Gaussem, Pascale; Bischoff, Joyce; Lopez-Novoa, José M; Bernabeu, Carmelo

    2016-04-01

    The circulatory system is walled off by different cell types, including vascular mural cells and podocytes. The interaction and interplay between endothelial cells (ECs) and mural cells, such as vascular smooth muscle cells or pericytes, play a pivotal role in vascular biology. Endoglin is an RGD-containing counter-receptor for β1 integrins and is highly expressed by ECs during angiogenesis. We find that the adhesion between vascular ECs and mural cells is enhanced by integrin activators and inhibited upon suppression of membrane endoglin or β1-integrin, as well as by addition of soluble endoglin (SolEng), anti-integrin α5β1 antibody or an RGD peptide. Analysis of different endoglin mutants, allowed the mapping of the endoglin RGD motif as involved in the adhesion process. In Eng (+/-) mice, a model for hereditary hemorrhagic telangectasia type 1, endoglin haploinsufficiency induces a pericyte-dependent increase in vascular permeability. Also, transgenic mice overexpressing SolEng, an animal model for preeclampsia, show podocyturia, suggesting that SolEng is responsible for podocytes detachment from glomerular capillaries. These results suggest a critical role for endoglin in integrin-mediated adhesion of mural cells and provide a better understanding on the mechanisms of vessel maturation in normal physiology as well as in pathologies such as preeclampsia or hereditary hemorrhagic telangiectasia.

  11. Mortality from Circulatory System Diseases and Malformations in Children in the State of Rio de Janeiro

    Science.gov (United States)

    Salim, Thais Rocha; Soares, Gabriel Porto; Klein, Carlos Henrique; de Oliveira, Glaucia Maria Moraes

    2016-01-01

    Background The epidemiological profile of mortality in a population is important for the institution of measures to improve health care and reduce mortality Objective To estimate mortality rates and the proportional mortality from cardiovascular diseases and malformations of the circulatory system in children and adolescents. Methods This is a descriptive study of mortality from cardiovascular diseases, malformations of the circulatory system, from all causes, ill-defined causes and external causes in children and adolescents in the state of Rio de Janeiro from 1996 to 2012. Populations were obtained from the Brazilian Institute of Geography and Statistics (Instituto Brasileiro de Geografia e Estatística - IBGE) and deaths obtained from the Department of Informatics of the Unified Health System (DATASUS)/Ministry of Health. Results There were 115,728 deaths from all causes, 69,757 in males. The annual mortality from cardiovascular diseases was 2.7/100,000 in men and 2.6/100,000 in women. The annual mortality from malformations of the circulatory system was 7.5/100,000 in men and 6.6/100,000 in women. Among the specific causes of circulatory diseases, cardiomyopathies had the highest rates of annual proportional mortality, and from malformations of the circulatory system, it occurred due to unspecified malformations of the circulatory system, at all ages and in both genders. Conclusion Mortality from malformations of the circulatory system was most striking in the first years of life, while cardiovascular diseases were more relevant in adolescents. Low access to prenatal diagnosis or at birth probably prevented the proper treatment of malformations of the circulatory system. PMID:27192384

  12. Circulatory Support with Venoarterial ECMO Unsuccessful in Aiding Endogenous Diltiazem Clearance after Overdose

    Directory of Open Access Journals (Sweden)

    Erin N. Frazee

    2014-01-01

    Full Text Available Introduction. In cardiovascular collapse from diltiazem poisoning, extracorporeal membrane oxygenation (ECMO may offer circulatory support sufficient to preserve endogenous hepatic drug clearance. Little is known about patient outcomes and diltiazem toxicokinetics in this setting. Case Report. A 36-year-old woman with a history of myocardial bridging syndrome presented with chest pain for which she self-medicated with 2.4 g of sustained release diltiazem over the course of 8 hours. Hemodynamics and mentation were satisfactory on presentation, but precipitously deteriorated after ICU transfer. She was given fluids, calcium, vasopressors, glucagon, high-dose insulin, and lipid emulsion. Due to circulatory collapse and multiorgan failure including ischemic hepatopathy, she underwent transvenous pacing and emergent initiation of venoarterial ECMO. The peak diltiazem level was 13150 ng/mL (normal 100–200 ng/mL and it remained elevated at 6340 ng/mL at hour 90. Unfortunately, the patient developed multiple complications which resulted in her death on ICU day 9. Conclusion. This case describes the unsuccessful use of ECMO for diltiazem intoxication. Although past reports suggest that support with ECMO may facilitate endogenous diltiazem clearance, it may be dependent on preserved hepatic function at the time of cannulation, a factor not present in this case.

  13. Energy transmission and power sources for mechanical circulatory support devices to achieve total implantability.

    Science.gov (United States)

    Wang, Jake X; Smith, Joshua R; Bonde, Pramod

    2014-04-01

    Left ventricular assist device therapy has radically improved congestive heart failure survival with smaller rotary pumps. The driveline used to power today's left ventricular assist devices, however, continues to be a source of infection, traumatic damage, and rehospitalization. Previous attempts to wirelessly power left ventricular assist devices using transcutaneous energy transfer systems have been limited by restrictions on separation distance and alignment between the transmit and receive coils. Resonant electrical energy transfer allows power delivery at larger distances without compromising safety and efficiency. This review covers the efforts to wirelessly power mechanical circulatory assist devices and the progress made in enhancing their energy sources.

  14. Biventricular Mechanical Circulatory Support Does Not Prevent Delayed Myocardial Ventricular Rupture following Myocardial Infarction

    Directory of Open Access Journals (Sweden)

    Yazhini Ravi

    2013-01-01

    Full Text Available Cardiogenic shock and myocardial rupture can complicate an acute myocardial infarction (AMI. A case is reported in which a 58-year-old male with an acute inferior myocardial infarction required placement of biventricular assist device for hemodynamic support eight days after the onset of his AMI; eleven days after his AMI, the patient developed abrupt onset of hemodynamic instability with massive bleeding from his chest tube due to delayed free wall myocardial rupture that was discovered when he was taking emergently to the operating room. Myocardial rupture in patients with a ventricular assist device should be considered in the differential diagnosis in the event of acute hemodynamic compromise. A high level of suspicion for such a complication should prompt aggressive and emergent actions including surgery. We present a case of delayed free wall myocardial rupture following an acute inferior wall myocardial infarction in a patient with biventricular mechanical circulatory support.

  15. THE FIRST EXPERIENCE IN CLINICAL APPLICATION OF DOMESTIC CIRCULATORY SUPPORT DEVICE ON BASIS OF IMPLANTABLE AXIAL PUMP FOR TWO STAGE HEART TRANSPLANTATION

    Directory of Open Access Journals (Sweden)

    S. V. Gautier

    2013-01-01

    Full Text Available The paper describes the first clinical experience in RF of successful application of domestic circulatory support device based on implantable axial pump for two stage heart transplantation. This case demonstrate the effec- tiveness and safety of our device (АВК-Н for a longtime (270 days left ventricular bypass and the ability to perform a successful transplantation of donor,s heart after application of this system

  16. THE FIRST EXPERIENCE IN CLINICAL APPLICATION OF DOMESTIC CIRCULATORY SUPPORT DEVICE ON BASIS OF IMPLANTABLE AXIAL PUMP FOR TWO STAGE HEART TRANSPLANTATION

    OpenAIRE

    S. V. Gautier; G. P. Itkin; S. Yu. Shemakin; R. Sh. Saitgareev; V. N. Poptsov; V. M. Zakharevich; G. A. Akopov; A. Ya. Kormer; T. A. Khalilulin; O. P. Shevchenko; А. М. Nevzorov; I. А. Filatov; S. V. Selishev

    2013-01-01

    The paper describes the first clinical experience in RF of successful application of domestic circulatory support device based on implantable axial pump for two stage heart transplantation. This case demonstrate the effec- tiveness and safety of our device (АВК-Н) for a longtime (270 days) left ventricular bypass and the ability to perform a successful transplantation of donor,s heart after application of this system

  17. Acute mechanical circulatory support for fulminant myocarditis complicated by cardiogenic shock.

    Science.gov (United States)

    Mody, Kanika P; Takayama, Hiroo; Landes, Elissa; Yuzefpolskaya, Melana; Colombo, Paolo C; Naka, Yoshifumi; Jorde, Ulrich P; Uriel, Nir

    2014-03-01

    In fulminant myocarditis complicated by cardiogenic shock, early mechanical circulatory support (MCS) may prevent cardiomyopathy and death. We sought to examine the outcomes of patients with fulminant myocarditis supported with MCS. A retrospective review of patients with acute cardiogenic shock treated with MCS from 2007 to 2013 was conducted, and patients with a diagnosis of fulminant myocarditis were included in this series. At our center, 260 patients received MCS for acute cardiogenic shock, and 11 were implanted for fulminant myocarditis. Eight received the Centrimag biventricular assist device (BIVAD), and three received veno-arterial extracorporeal membrane oxygenator (VA ECMO), though 1 VA ECMO-supported patient was transitioned to BIVAD due to refractory shock. The mean acute support time was 14.7 ± 4.4 days. Two patients required long-term left ventricular assist devices and were further supported for 55 and 112 days. Eight patients recovered with a mean ejection fraction of 54 ± 7 %, and one was successfully transplanted. Eight patients survived to discharge (73 %) with mean follow-up: 292.6 ± 306.8 days. All three deaths were due to neurologic complications. MCS should be considered in patients with fulminant myocarditis complicated by shock. With aggressive medical therapy, early utilization of MCS carries promising outcomes.

  18. [Forming a community at risk for circulatory system diseases among workers engaged into underground mining].

    Science.gov (United States)

    Shliapnikov, D M; Shur, P Z; Kostarev, V G; Alexeyev, V B; Vlasova, E M; Uhabov, V M

    2015-01-01

    Forming a community at risk for circulatory system diseases will increase efficiency of medical and prophylactic measures on managing risk of arterial hypertension. Epidemiologic analysis helped to reveal reliable connection between arterial hypertension predictors and work conditions of mining machine operators and supported actualization of high occupational risk suggested in a priori evaluation. Mathematic modelling helped to forecast increase in the disease probability: with noise level of 94 dB after 10 years of work, 17.9% of workers are expected to have arterial hypertension preventing from further occupational activity. Forecasting results of arterial hypertension probability help to form risk groups for medical and preventive technologies managing occupational risk, and predictors enable to specify necessity of individual medical preventive measures.

  19. Factors influencing the outcome of paediatric cardiac surgical patients during extracorporeal circulatory support

    Directory of Open Access Journals (Sweden)

    Peek Giles J

    2007-01-01

    Full Text Available Abstract Background Veno-arterial extracorporeal membrane oxygenation (ECMO is a common modality of circulatory assist device used in children. We assessed the outcome of children who had ECMO following repair of congenital cardiac defects (CCD and identified the risk factors associated with hospital mortality. Methods From April 1990 to December 2003, 53 patients required ECMO following surgical correction of CCD. Retrospectively collected data was analyzed with univariate and multivariate logistic regression analysis. Results Median age and weight of the patients were 150 days and 5.4 kgs respectively. The indications for ECMO were low cardiac output in 16, failure to wean cardiopulmonary bypass in 13, cardiac arrest in 10 and cardio-respiratory failure in 14 patients. The mean duration of ECMO was 143 hours. Weaning off from ECMO was successful in 66% and of these 83% were survival to hospital-discharge. 37.7% of patients were alive for the mean follow-up period of 75 months. On univariate analysis, arrhythmias, ECMO duration >168 hours, bleeding complications, renal replacement therapy on ECMO, arrhythmias and cardiac arrest after ECMO were associated with hospital mortality. On multivariate analysis, abnormal neurology, bleeding complications and arrhythmias after ECMO were associated with hospital mortality. Extra and intra-thoracic cannulations were used in 79% and 21% of patients respectively and extra-thoracic cannulation had significantly less bleeding complications (p = 0.031. Conclusion ECMO provides an effective circulatory support following surgical repair of CCD in children. Extra-thoracic cannulation is associated with less bleeding complications. Abnormal neurology, bleeding complications on ECMO and arrhythmias after ECMO are poor prognostic indicators for hospital survival.

  20. Predictors of Death and Transplant in Patients With a Mechanical Circulatory Support Device : A Multi-institutional Study

    NARCIS (Netherlands)

    Holman, William L.; Kormos, Robert L.; Naftel, David C.; Miller, Marissa A.; Pagani, Frank D.; Blume, Elizabeth; Cleeton, Timothy; Koenig, Steven C.; Edwards, Leah; Kirklin, James K.

    2009-01-01

    Background: INTERMACS is a registry of FDA-approved durable mechanical circulatory support (MCS) devices used for the strategies of destination therapy (DT) and bridge to transplantation (BTT) or recovery. This study identifies predictors for death and transplantation based on initial results from I

  1. Mechanical Circulatory Support Devices Improve Tissue Perfusion in Patients With End-Stage Heart Failure or Cardiogenic Shock

    NARCIS (Netherlands)

    C.A. den Uil; A.P. Maat; W.K. Lagrand; M. van der Ent; L.S.D. Jewbali; R.J. van Thiel; P.E. Spronk; M.L. Simoons

    2009-01-01

    Objectives: This study evaluated the effects of mechanical circulatory support (MCS) on sub-lingual microcirculation as a surrogate for splanchnic microvascular perfusion. Methods: Between May 2008 and April 2009, 10 consecutive patients received an MCS device or extracorporeal membrane oxygenation

  2. Diseases of the circulatory system among adult people diagnosed with infantile autism as children

    DEFF Research Database (Denmark)

    Mouridsen, Svend Erik; Rich, Bente; Isager, Torben

    2016-01-01

    frequently among people in the comparison group (p=0.02). CONCLUSIONS AND IMPLICATIONS: It is argued that diseases of the circulatory system may be underdiagnosed in people with IA because of the difficulties they face with respect to identifying and communicating symptoms of ill health. Bearing in mind......BACKGROUND: Research dealing with adult people with autism spectrum disorders (ASD) noticeably lags behind studies of children and young individuals with ASD. AIMS: The objective of this study was to compare the prevalence and types of diseases of the circulatory system in a clinical sample of 118......, and mean age at follow-up was 49.6 years. OUTCOMES AND RESULTS: Of the 118 people with IA, 11 (9.3%) were registered with at least one disease of the circulatory system against 54 (16.1%) in the comparison group (p=0.09; OR=0.54; 95% CI 0.3-1.2). Ischemic heart diseases occurred significantly more...

  3. Circulatory support devices: fundamental aspects and clinical management of bleeding and thrombosis.

    Science.gov (United States)

    Susen, S; Rauch, A; Van Belle, E; Vincentelli, A; Lenting, P J

    2015-10-01

    Circulatory support devices are increasingly being used to overcome cardiac or respiratory failure. Long-term devices are used either as a 'bridge to transplant' to support patients who are unable to wait any longer for a heart transplant, or, more recently, as 'destination therapy' for older patients suffering from end-stage heart failure and who have contraindications to heart transplantation. Short-term support devices for high-risk percutaneous coronary intervention, or as a 'bridge for decision' for patients suffering from refractory cardiogenic shock, have also been developed. The clinical benefit of such assist devices has been demonstrated in several important studies, but, unfortunately, thrombotic and bleeding complications are two major clinical issues in patients requiring these devices. Overcoming these issues is of major importance to allow the safe and broad use of these devices, and to consider them as true alternatives to heart transplantation. The present review focuses on thrombotic and bleeding complications, and describes how the risk of thrombosis and bleeding may vary according to the clinical indication, but also according to the type of device. We describe the current knowledge of the mechanisms underlying the occurrence of these complications, provide some guidance for choosing the most appropriate anticoagulation regimen to prevent their occurrence for each type of device and indication, and provide some recommendations for the management of patients when the complication occurs.

  4. PERIPHERAL VENO-ARTERIAL ECMO AS MECHANICAL CIRCULATORY SUPPORT BEFORE HEART TRANSPLANTATION

    Directory of Open Access Journals (Sweden)

    E. A. Spirina

    2013-01-01

    Full Text Available Aim of our clinical study was evaluation own initial experience of high-urgency ortotopic heart transplantation (OHT in recipients, who were bridged on peripheral Vena-Arterial Extracorporeal Membrane Oxygenation (VA ECMO. Materials and methods. In this study was included 17 patients (14/3 M/F, age 16–66 (40.1 ± 4.2 yrs who underwent OHT while on peripheral ECMO support. In all cases we used peripheral surgical can- nulation technique via femoral vessels – arterial cannula 15–19 Fr, venous cannula – 21–25 Fr, arterial cannula or vascular catheter 8–10 Fr for anterograde leg’s perfusion. Results. Duration Vena-Arterial Extracorporeal Membrane Oxygenation before OHT was 81 ± 17 h. VA ECMO support was blood flow 4.8 ± 0.6 l/min or 2.63 ± 0/04 l/min/m2, gas flow 4.8 ± 0.6 l/min, FiO2 0.86 ± 0.07. Vena-Arterial Extracorporeal Membrane Oxygenation support was continued in “protective mode” (blood flow 1.9 ± 0.2 l/min 4.3 ± 0.5 days after OHT. Thirteen pa- tients (76.4% were weaned from VA ECMO successfully and survived to be discharged. ICU and hospital LOS after orthotopic heart transplantation was respectively 6.7 ± 0.8 and 32.3 ± 4.6 days in group of survived patients. The reasons of a lethal outcome (n = 4, 23.5% were sepsis and multiorgan failure (n = 3, sudden cardiac arrest (n = 1. Conclusion. Vena-Arterial Extracorporeal Membrane Oxygenation is a favorable short-term method of circulatory support in patients who needed in high-urgency heart transplantation. 

  5. Developing seventh grade students' systems thinking skills in the context of the human circulatory system.

    Science.gov (United States)

    Raved, Lena; Yarden, Anat

    2014-01-01

    Developing systems thinking skills in school can provide useful tools to deal with a vast amount of medical and health information that may help learners in decision making in their future lives as citizen. Thus, there is a need to develop effective tools that will allow learners to analyze biological systems and organize their knowledge. Here, we examine junior high school students' systems thinking skills in the context of the human circulatory system. A model was formulated for developing teaching and learning materials and for characterizing students' systems thinking skills. Specifically, we asked whether seventh grade students, who studied about the human circulatory system, acquired systems thinking skills, and what are the characteristics of those skills? Concept maps were used to characterize students' systems thinking components and examine possible changes in the students' knowledge structure. These maps were composed by the students before and following the learning process. The study findings indicate a significant improvement in the students' ability to recognize the system components and the processes that occur within the system, as well as the relationships between different levels of organization of the system, following the learning process. Thus, following learning students were able to organize the systems' components and its processes within a framework of relationships, namely the students' systems thinking skills were improved in the course of learning using the teaching and learning materials.

  6. Optimization of Centrifugal Pump Characteristic Dimensions for Mechanical Circulatory Support Devices.

    Science.gov (United States)

    Korakianitis, Theodosios; Rezaienia, Mohammad A; Paul, Gordon M; Rahideh, Akbar; Rothman, Martin T; Mozafari, Sahand

    2016-01-01

    The application of artificial mechanical pumps as heart assist devices impose power and size limitations on the pumping mechanism, and therefore requires careful optimization of pump characteristics. Typically new pumps are designed by relying on the performance of other previously designed pumps of known performance using concepts of fluid dynamic similarity. Such data are readily available for industrial pumps, which operate in Reynolds numbers region of 10. Heart assist pumps operate in Reynolds numbers of 10. There are few data available for the design of centrifugal pumps in this characteristic range. This article develops specific speed versus specific diameter graphs suitable for the design and optimization of these smaller centrifugal pumps concentrating in dimensions suitable for ventricular assist devices (VADs) and mechanical circulatory support (MCS) devices. A combination of experimental and numerical techniques was used to measure and analyze the performance of 100 optimized pumps designed for this application. The data are presented in the traditional Cordier diagram of nondimensional specific speed versus specific diameter. Using these data, nine efficient designs were selected to be manufactured and tested in different operating conditions of flow, pressure, and rotational speed. The nondimensional results presented in this article enable preliminary design of centrifugal pumps for VADs and MCS devices.

  7. Role of long-term mechanical circulatory support in patients with advanced heart failure.

    Science.gov (United States)

    Stokes, M B; Bergin, P; McGiffin, D

    2016-05-01

    Advanced heart failure represents a small proportion of patients with heart failure that possess high-risk features associated with high hospital readmission rates, significant functional impairment and mortality. Identification of those who have progressed to, or are near a state of advanced heart failure should prompt referral to a service that offers therapies in mechanical circulatory support (MCS) and cardiac transplantation. MCS has grown as a management strategy in the care of these patients, most commonly as a bridge to cardiac transplantation. The predominant utilisation of MCS is implantation of left ventricular assist devices (LVAD), which have evolved significantly in their technology and application over the past 15-20 years. The technology has evolved to such an extent that Destination Therapy is now being utilised as a strategy in management of advanced heart failure in appropriately selected patients. Complication rates have decreased with VAD implantation, but remain a significant consideration in the decision to implant a device, and in the follow up of these patients.

  8. Nursing diagnoses and outcomes related to the circulatory-system terms (ICNP® represented in an ontology

    Directory of Open Access Journals (Sweden)

    Marcia Regina Cubas

    2013-10-01

    Full Text Available The aim of the present study was to develop titles of Nursing Diagnoses and Outcomes (ND/NO through the relationship between the terms of the Focus axis, limited to the Circulatory System Process, and the terms of other ICNP® axes and to integrate these terms into an ontology. Titles were developed linking 17 terms of the focus axis, which were evaluated by expert nurses in five Brazilian cities. Titles whose use concordance was above 0.80 were included in the ontology. In total, 89 titles for ND/NO were supported in the literature, and 19 were not supported; 37 were assessed as eligible for use in healthcare practice and were included in the ontology. The construction of ND/NO titles based on the ICNP® and using a formal representation of knowledge is a task that requires deepening concepts used for nursing and adequate classification revisions. The elaborated titles will facilitate the composition of diagnostics that are more consistent with practice.

  9. End-stage heart failure and mechanical circulatory support: feasibility of discharge from hospital.

    Science.gov (United States)

    Oosterom, A; de Jonge, N; Kirkels, J H; Rodermans, B F M; Sukkel, E; Klöpping, C; Ramjankhan, F; Lahpor, J R

    2007-01-01

    BACKGROUND.: Due to the shortage of donor hearts, mechanical circulatory support is increasingly being used as a bridge to transplantation. In order to allow for more widespread use of ventricular assist devices it is mandatory that patients are not continuously hospitalised. We present the results of our experience with patients with end-stage heart failure, discharged from hospital after implantation of a ventricular assist device and followed in an outpatient setting. METHODS.: After an intensive training and education programme, focusing on the management of the percutaneous driveline and instructions on how to handle in case of an alarm or malfunction of the device, patients were discharged. They were followed in the outpatient department. All regular and unplanned visits were registered, including readmissions. RESULTS.: Twenty-seven patients treated with a ventricular assist device were discharged from hospital. There were 37 extra visits, of these, 27 were device related resulting in 21 readmissions (0.78/patient). We treated eight infectious episodes in four patients, all device related. Furthermore seven thromboembolic episodes occurred in four patients. One patient died because of multiorgan failure seven weeks after he was readmitted with an urosepsis. In our experience of 11.4 patient years at home while on the device, only 5% of the time was spent in hospital for complications. In comparison with patients on an assist device who stayed in hospital until transplantation, there were no more complications. CONCLUSION.: This study demonstrates that patients with end-stage heart failure, treated with a ventricular assist device, can be safely discharged from hospital, with an acceptable rate of readmissions. It results in a fair quality of life, with a high degree of independence of the patient. (Neth Heart J 2007;15:45-50.).

  10. Prevalence of Warfarin Genotype Polymorphisms in Patients with Mechanical Circulatory Support.

    Science.gov (United States)

    Awad, Morcos; Czer, Lawrence S C; Soliman, Camelia; Mirocha, James; Ruzza, Andrea; Pinzas, Joshua; Rihbany, Kelsey; Chang, David; Moriguchi, Jaime; Ramzy, Danny; Esmailian, Fardad; Kobashigawa, Jon; Arabia, Francisco

    2015-01-01

    Polymorphisms for VKORC1 and CYP2C9 are associated with increased warfarin sensitivity. The prevalence of these polymorphisms in patients with mechanical circulatory support (MCS) is unknown. Polymorphisms for VKORC1 and CYP2C9 were determined in 65 patients undergoing MCS surgery. Postoperative warfarin dose, international normalized ratio (INR), and bleeding events were measured until discharge, 6 months, or composite end point (in-hospital MCS recovery, heart transplant, or death). A total of 67.7% (44/65) had at least one polymorphism: VKORC1 (44.6%), CYP2C9*2 (7.7%), CYP2C9*3 (4.6%), CYP2C9*2 and VKORC1 (3.1%), or CYP2C9*3 and VKORC1 (7.7%). At discharge or before composite end point, patients with any polymorphism received a lower mean warfarin dosage than patients having no polymorphism (3.21 ± 1.47 vs. 5.57 ± 3.72 mg, p = 0.015) and achieved a similar mean INR (2.20 ± 0.67 vs. 2.19 ± 0.69, p = 0.96). There was no significant difference in bleeding rates within 6 months or before composite end point (6.13 vs. 8.02 events/patient-year, p = 0.13). One or more polymorphisms for VKORC1 or CYP2C9 (associated with warfarin sensitivity) were found in 67.7% of MCS patients. By using a warfarin genotype-guided approach, MCS patients with polymorphisms received a lower warfarin dosage to achieve a similar INR, with similar bleeding rates, in comparison with no polymorphisms. A warfarin genotype-guided approach avoided excessive anticoagulation and its attendant bleeding risks.

  11. Myocardial Oxidative Metabolism and Protein Synthesis during Mechanical Circulatory Support by Extracorporeal Membrane Oxygenation

    Energy Technology Data Exchange (ETDEWEB)

    Priddy, MD, Colleen M.; Kajimoto, Masaki; Ledee, Dolena; Bouchard, Bertrand; Isern, Nancy G.; Olson, Aaron; Des Rosiers, Christine; Portman, Michael A.

    2013-02-01

    Extracorporeal membrane oxygenation (ECMO) provides mechanical circulatory support essential for survival in infants and children with acute cardiac decompensation. However, ECMO also causes metabolic disturbances, which contribute to total body wasting and protein loss. Cardiac stunning can also occur which prevents ECMO weaning, and contributes to high mortality. The heart may specifically undergo metabolic impairments, which influence functional recovery. We tested the hypothesis that ECMO alters oxidative. We focused on the amino acid leucine, and integration with myocardial protein synthesis. We used a translational immature swine model in which we assessed in heart (i) the fractional contribution of leucine (FcLeucine) and pyruvate (FCpyruvate) to mitochondrial acetyl-CoA formation by nuclear magnetic resonance and (ii) global protein fractional synthesis (FSR) by gas chromatography-mass spectrometry. Immature mixed breed Yorkshire male piglets (n = 22) were divided into four groups based on loading status (8 hours of normal circulation or ECMO) and intracoronary infusion [13C6,15N]-L-leucine (3.7 mM) alone or with [2-13C]-pyruvate (7.4 mM). ECMO decreased pulse pressure and correspondingly lowered myocardial oxygen consumption (~ 40%, n = 5), indicating decreased overall mitochondrial oxidative metabolism. However, FcLeucine was maintained and myocardial protein FSR was marginally increased. Pyruvate addition decreased tissue leucine enrichment, FcLeucine, and Fc for endogenous substrates as well as protein FSR. Conclusion: The heart under ECMO shows reduced oxidative metabolism of substrates, including amino acids, while maintaining (i) metabolic flexibility indicated by ability to respond to pyruvate, and (ii) a normal or increased capacity for global protein synthesis, suggesting an improved protein balance.

  12. Bridge to recovery in two cases of dilated cardiomyopathy after long-term mechanical circulatory support.

    Science.gov (United States)

    Pacholewicz, Jerzy; Zakliczyński, Michał; Kowalik, Violetta; Nadziakiewicz, Paweł; Kowalski, Oskar; Kalarus, Zbigniew; Zembala, Marian

    2014-06-01

    Ventricular assist devices (VADs) have become an established therapeutic option for patients with end-stage heart failure. Achieving the potential for recovery of native heart function using VADs is an established form of treatment in a selected group of patients with HF. We report two cases of VAD patients with different types of pump used for mechanical circulatory support, a continuous flow pump (Heart-Ware(®)) and a pulsatile pump (POLVAD MEV(®)), which allow regeneration of the native heart. Patients were qualified as INTERMACS level 3-4 for elective implantation of an LVAD. Implantations were performed without complications. The postoperative course was uncomplicated. In the HeartWare patient the follow-up was complicated by episodes of epistaxis and recurrent GIB as well as driveline infection. The follow-up of the POLVAD MEV patient was uneventful. Recurrent GIB forced us to withdraw aspirin and warfarin therapy and maintain only clopidogrel in the HeartWare patient.. In mid-February 2013 the patient was admitted due to dysfunction of the centrifugal pump with a continuous low-flow alarm and increase power consumption. Under close monitoring of the patient a decision was made to stop the pump immediately and evaluate cardiac function. The serial echocardiography studies showed significant improvement in LVEF up to 45% and no significant valvular pathology. In February 2013 LVAD explant was performed by left thoracotomy without complications. At six-month follow-up the patient was in a good clinical condition, in NYHA class I/II, and on pharmacological treatment.

  13. Control of Cell Fate in the Circulatory and Ventilatory Systems

    CERN Document Server

    Thiriet, Marc

    2012-01-01

    The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volumes 1 and 2 are devoted to cell organization and fate, as well as activities that are autoregulated and/or controlled by the cell environment. Volume 1 examined cellular features that allow adaptation to env...

  14. Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems

    CERN Document Server

    Thiriet, Marc

    2013-01-01

    The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors.  Activation of...

  15. Tissue Functioning and Remodeling in the Circulatory and Ventilatory Systems

    CERN Document Server

    Thiriet, Marc

    2013-01-01

    The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. Volume 5 is devoted to cells, tissues, and organs of the cardiovascular and ventilatory systems with an emphasis on mechanotransduction-based regulation of flow. The blood vessel wall is a living tissue that quickly reacts to loads applied on it by the flowing blood. In any segment of a blood vessel, the endothelial and smooth muscle cells can sense unusual time variations in small-magnitude wall shear stress and large-amplitude wall stretch generated by abnormal hemodynamic stresses. These cells respond with a short-time scale (from seconds to hours) to adapt the vessel caliber. Since such adaptive cell activities can be described using mathematical models, a key objective of this volume is to identify the mesoscopic agents and nanoscopic mediators required to derive adequate mathematical models...

  16. Optical Dynamic Analysis of Thrombus Inside a Centrifugal Blood Pump During Extracorporeal Mechanical Circulatory Support in a Porcine Model.

    Science.gov (United States)

    Fujiwara, Tatsuki; Sakota, Daisuke; Ohuchi, Katsuhiro; Endo, Shu; Tahara, Tomoki; Murashige, Tomotaka; Kosaka, Ryo; Oi, Keiji; Mizuno, Tomohiro; Maruyama, Osamu; Arai, Hirokuni

    2017-03-20

    Complications due to pump thrombus remain the weak point of mechanical circulatory support (MCS), such as the use of a left ventricular assist device (LVAD) or extracorporeal membrane oxygenation, leading to poor outcomes. Hyperspectral imaging (HSI) is an effective imaging method using a hyperspectral (HS) camera, which comprises a spectrophotometer and a charge-coupled device camera to discriminate thrombus from whole blood. Animal experiments were conducted to analyze dynamic imaging of thrombus inside a prototype of a hydrodynamically levitated centrifugal blood pump using an HSI system. Six pigs were divided into a venous circulation group (n = 3) and an arterial circulation group (n = 3). Inflow and outflow cannulae were inserted into the jugular veins in the venous circulation group. The latter simulated an LVAD application. To create thrombogenic conditions, pump flow was maintained at 1 L/min without anticoagulation. An image of the bottom surface of the pump was captured by the HS camera every 4 nm over the wavelength range of 608-752 nm. Real-time dynamic images of the inside of the pump were displayed on the monitor. Appearance of an area displaying thrombus was detected within 24 h after the start of the circulation in every experiment. This imaging system also succeeded in determining the origins of pump thrombus: from inside the pump in two cases, and from outside in four cases. Two main possible sources of pump thrombus originating outside the pump were identified on autopsy: wedge thrombus around the inflow cannula; and string-like thrombus at the junction between the pump inlet and circuit tube. The results of this study from close observation of the changing appearance of pump thrombus may contribute to improvements in the safety of extracorporeal MCS.

  17. Von Willebrand factor in patients on mechanical circulatory support – a double-edged sword between bleeding and thrombosis

    Science.gov (United States)

    Kaczmarski, Jacek; Pacholewicz, Jerzy; Zakliczynski, Michal; Gasior, Mariusz; Zembala, Marian

    2015-01-01

    Mechanical circulatory support (MCS) is an umbrella term describing the various technologies used in both short- and long-term management of patients with either end-stage chronic heart failure (HF) or acute HF. Most often, MCS has emerged as a bridge to transplantation, but more recently it is also used as a destination therapy. Mechanical circulatory support includes left ventricular assist device (LVAD) or bi-ventricular assist device (Bi-VAD). Currently, 2- to 3-year survival in carefully selected patients is much better than with medical therapy. However, MCS therapy is hampered by sometimes life-threatening complications including bleeding and device thrombosis. Von Willebrand factor (vWF) has two major functions in haemostasis. First, it plays a crucial role in platelet-subendothelium adhesion and platelet-platelet interactions (aggregation). Second, it is the carrier of factor VIII (FVIII) in plasma. Von Willebrand factor prolongs FVIII half-time by protecting it from proteolytic degradation. It delivers FVIII to the site of vascular injury thus enhancing haemostatic process. On one hand, high plasma levels of vWF have been associated with an increased risk of thrombosis. On the other, defects or deficiencies of vWF underlie the inherited von Willebrand disease or acquired von Willebrand syndrome. Here we review the pathophysiology of thrombosis and bleeding associated with vWF. PMID:26702279

  18. Von Willebrand factor in patients on mechanical circulatory support - a double-edged sword between bleeding and thrombosis.

    Science.gov (United States)

    Hudzik, Bartosz; Kaczmarski, Jacek; Pacholewicz, Jerzy; Zakliczynski, Michal; Gasior, Mariusz; Zembala, Marian

    2015-09-01

    Mechanical circulatory support (MCS) is an umbrella term describing the various technologies used in both short- and long-term management of patients with either end-stage chronic heart failure (HF) or acute HF. Most often, MCS has emerged as a bridge to transplantation, but more recently it is also used as a destination therapy. Mechanical circulatory support includes left ventricular assist device (LVAD) or bi-ventricular assist device (Bi-VAD). Currently, 2- to 3-year survival in carefully selected patients is much better than with medical therapy. However, MCS therapy is hampered by sometimes life-threatening complications including bleeding and device thrombosis. Von Willebrand factor (vWF) has two major functions in haemostasis. First, it plays a crucial role in platelet-subendothelium adhesion and platelet-platelet interactions (aggregation). Second, it is the carrier of factor VIII (FVIII) in plasma. Von Willebrand factor prolongs FVIII half-time by protecting it from proteolytic degradation. It delivers FVIII to the site of vascular injury thus enhancing haemostatic process. On one hand, high plasma levels of vWF have been associated with an increased risk of thrombosis. On the other, defects or deficiencies of vWF underlie the inherited von Willebrand disease or acquired von Willebrand syndrome. Here we review the pathophysiology of thrombosis and bleeding associated with vWF.

  19. Clinical Outcomes of Advanced Heart Failure Patients with Cardiogenic Shock Treated with Temporary Circulatory Support Before Durable LVAD Implant.

    Science.gov (United States)

    Shah, Palak; Smith, Sara; Haft, Jonathan W; Desai, Shashank S; Burton, Nelson A; Romano, Matthew A; Aaronson, Keith D; Pagani, Francis D; Cowger, Jennifer A

    2016-01-01

    Temporary circulatory support (TCS) is used to improve hemodynamics in patients with cardiogenic shock as a bridge to durable ventricular assist device (dVAD). Data from dVAD recipients with or without TCS (extracorporeal membranous oxygenation [ECMO], n = 14; TandemHeart [TH], n = 26) were evaluated. Clinical characteristics and hemodynamics were analyzed for patients before and after TCS and compared with profile 1 (n = 29) or profile 2-3 (n = 269) patients without TCS before dVAD. Extracorporeal membranous oxygenation patients had the highest use of preoperative mechanical ventilation, vasopressors, and the highest HeartMate II risk score before dVAD (p < 0.01). Patients receiving TCS before dVAD implant had hemodynamics comparable with patients in Profiles 2-3 and superior to that of Profile 1 patients without TCS. Operative survival after dVAD was lower in patients receiving ECMO (57%) compared with Profile 1 patients receiving TH (88%), Profile 1 without TCS (82%), or Profile 2-3 patients (97%; all p < 0.01). Despite improved clinical stability with TCS, patients bridged to a dVAD have event-free survival that parallels patients in profile 1 without TCS. Our data suggest that patients requiring TCS before dVAD implant should be still classified Interagency Registry for Mechanically Assisted Circulatory Support profile 1.

  20. Burden of Circulatory System Diseases and Ignored Barriers ofKnowledge Translation

    Directory of Open Access Journals (Sweden)

    Hamed-Basir Ghafouri

    2012-10-01

    Full Text Available Circulatory system disease raise third highest disability-adjusted life years among Iranians and ischemic cardiac diseases are main causes for such burden. Despite available evidences on risk factors of the disease, no effective intervention was implemented to control and prevent the disease. This paper non-systematically reviews available literature on the problem, solutions, and barriers of implementation of knowledge translation in Iran. It seems that there are ignored factors such as cultural and motivational issues in knowledge translation interventions but there are hopes for implementation of started projects and preparation of students as next generation of knowledge transferors.

  1. Efficiency of Reflex Therapy in Complex Treatment of Circulatory Disturbances in Vertebrobasilar System

    Directory of Open Access Journals (Sweden)

    Goydenko V. S.

    2016-12-01

    Full Text Available The article deals with a complex examination and treatment of 198 patients (142 women and 56 men with circulatory disturbances in vertebrobasilar. Mean age of patients was 53.8±7.1 years. Reflex therapy including reflex therapy and biodynamic backbone correction was shown to increase the efficiency of complex therapy, allows to effect different chains of the developed pathological system, the fact confirmed by the dynamics of neurologic syndromes and dynamics of cerebrovascular reactivity at transcranial Doppler sonography.

  2. An extended computational model of the circulatory system for designing ventricular assist devices.

    Science.gov (United States)

    Hsu, Po-Lin; Cheng, Sean J; Saumarez, Richard C; Dawes, William N; McMahon, Richard A

    2008-01-01

    An extended computational model of the circulatory system has been developed to predict blood flow in the presence of ventricular assist devices (VADs). A novel VAD, placed in the descending aorta, intended to offload the left ventricle (LV) and augment renal perfusion is being studied. For this application, a better understanding of the global hemodynamic response of the VAD, in essence an electrically driven pump, and the cardiovascular system is necessary. To meet this need, a model has been established as a nonlinear, lumped-parameter electrical analog, and simulated results under different states [healthy, congestive heart failure (CHF), and postinsertion of VAD] are presented. The systemic circulation is separated into five compartments and the descending aorta is composed of three components to accurately yield the system response of each section before and after the insertion of the VAD. Delays in valve closing time and blood inertia in the aorta were introduced to deliver a more realistic model. Pump governing equations and optimization are based on fundamental theories of turbomachines and can serve as a practical initial design point for rotary blood pumps. The model's results closely mimic established parameters for the circulatory system and confirm the feasibility of the intra-aortic VAD concept. This computational model can be linked with models of the pump motor to provide a valuable tool for innovative VAD design.

  3. Diseases of the circulatory system: health status and perspectives for changes

    Directory of Open Access Journals (Sweden)

    V. I. Klimenko

    2014-02-01

    Full Text Available During last 20 years rates of incidence and prevalence of diseases of the circulatory system in Ukraine have been growing from year to year and became problems of current interest. According to the program of WHO, realization of diseases prevention is provided by using of scientific justification and monitoring of health indexes, including diseases of the circulatory system. Goal of our research was to analyze health status of population of Zaporozhye region concerning cardiovascular diseases. Data since 1995 to 2012 y. were taken in the Center of medical statistics of Zaporozhye region. Comparative analysis of obtained data was conducted in dynamics and with definition of specific weight of able to work population in structure of indexes and gender differences. In article we showed, that on the background of depopulation of Ukraine during last 20 years, prevalence of diseases of the circulatory system increased by 2 times, and level of mortality from them increased for 45%. Specific weight of mortality from diseases of the circulatory system among adult population (state for 01.2013 y. in Ukraine was 65,7%, in Zaporozhye region – 63,6%, among able to work population – 30,5%, in Zaporozhye region – 33,4%, but mortality among able to work men in Zaporozhye region was in 5,5 times higher than in women. Specific weight of the diseases of the circulatory system in structure of general morbidity in total population in Ukraine was 31,5%, among able to work population – 24,1%; among total population of Zaporozhye region – 36,6% (in town – 35,0%; in country region – 39,8%, among able to work population of Zaporozhye region – 24,6% (in town – 22,8%; in country region – 27,6%. Structure of general morbidity of the cardiovascular diseases during last 10 years in Ukraine and in Zaporozhye region is stable. Leading place belongs to arterial hypertension: 56,1%- in Ukraine, 57,7 % - in Zaporozhye region. Comparing to Ukraine, before 2005 y

  4. Physiologic benefits of pulsatile perfusion during mechanical circulatory support for the treatment of acute and chronic heart failure in adults.

    Science.gov (United States)

    Guan, Yulong; Karkhanis, Tushar; Wang, Shigang; Rider, Alan; Koenig, Steven C; Slaughter, Mark S; El Banayosy, Aly; Undar, Akif

    2010-07-01

    A growing population experiencing heart failure (100,000 patients/year), combined with a shortage of donor organs (less than 2200 hearts/year), has led to increased and expanded use of mechanical circulatory support (MCS) devices. MCS devices have successfully improved clinical outcomes, which are comparable with heart transplantation and result in better 1-year survival than optimal medical management therapies. The quality of perfusion provided during MCS therapy may play an important role in patient outcomes. Despite demonstrated physiologic benefits of pulsatile perfusion, continued use or development of pulsatile MCS devices has been widely abandoned in favor of continuous flow pumps owing to the large size and adverse risks events in the former class, which pose issues of thrombogenic surfaces, percutaneous lead infection, and durability. Next-generation MCS device development should ideally implement designs that offer the benefits of rotary pump technology while providing the physiologic benefits of pulsatile end-organ perfusion.

  5. Noninvasive optoacoustic system for rapid diagnostics and management of circulatory shock

    Science.gov (United States)

    Esenaliev, Rinat O.; Petrov, Irene Y.; Petrov, Yuriy; Kinsky, Michael; Prough, Donald S.

    2012-02-01

    Circulatory shock is lethal, if not promptly diagnosed and effectively treated. Typically, circulatory shock resuscitation is guided by blood pressure, heart rate, and mental status, which have poor predictive value. In patients, in whom early goaldirected therapy was applied using central venous oxygenation measurement, a substantial reduction of mortality was reported (from 46.5% to 30%). However, central venous catheterization is invasive, time-consuming and often results in complications. We proposed to use the optoacoustic technique for noninvasive, rapid assessment of central venous oxygenation. In our previous works we demonstrated that the optoacoustic technique can provide measurement of blood oxygenation in veins and arteries due to high contrast and high resolution. In this work we developed a novel optoacoustic system for noninvasive, automatic, real-time, and continuous measurement of central venous oxygenation. We performed pilot clinical tests of the system in human subjects with different oxygenation in the internal jugular vein and subclavian vein. A novel optoacoustic interface incorporating highly-sensitive optoacoustic probes and standard ultrasound imaging probes were developed and built for the study. Ultrasound imaging systems Vivid i and hand-held Vscan (GE Healthcare) as well as Site-Rite 5 (C.R. Bard) were used in the study. We developed a special algorithm for oxygenation monitoring with minimal influence of overlying tissue. The data demonstrate that the system provides precise measurement of venous oxygenation continuously and in real time. Both current value of the venous oxygenation and trend (in absolute values and for specified time intervals) are displayed in the system. The data indicate that: 1) the optoacoustic system developed by our group is capable of noninvasive measurement of blood oxygenation in specific veins; 2) clinical ultrasound imaging systems can facilitate optoacoustic probing of specific blood vessels; 3) the

  6. Assessment of left heart and pulmonary circulation flow dynamics by a new pulsed mock circulatory system

    Science.gov (United States)

    Tanné, David; Bertrand, Eric; Kadem, Lyes; Pibarot, Philippe; Rieu, Régis

    2010-05-01

    We developed a new mock circulatory system that is able to accurately simulate the human blood circulation from the pulmonary valve to the peripheral systemic capillaries. Two independent hydraulic activations are used to activate an anatomical-shaped left atrial and a left ventricular silicon molds. Using a lumped model, we deduced the optimal voltage signals to control the pumps. We used harmonic analysis to validate the experimental pulmonary and systemic circulation models. Because realistic volumes are generated for the cavities and the resulting pressures were also coherent, the left atrium and left ventricle pressure-volume loops were concordant with those obtained in vivo. Finally we explored left atrium flow pattern using 2C-3D+T PIV measurements. This gave a first overview of the complex 3D flow dynamics inside realistic left atrium geometry.

  7. Usefulness of extracorporeal membrane oxygenation using double roller pumps in a low body weight newborn: A novel strategy for mechanical circulatory support in an infant

    Directory of Open Access Journals (Sweden)

    Keisuke Nakanishi

    2016-01-01

    Full Text Available Extracorporeal membrane oxygenation (ECMO with a centrifugal pump requires a certain flow rate; therefore, its application for low body weight infants is frequently accompanied by oxygenator membrane malfunction and/or inadequate perfusion. To prevent low-flow associated complications, we report a case in which a novel system of dual roller pumps was used. A baby girl with a body mass index 0.25 m 2 , who experienced difficulty weaning from cardiopulmonary bypass after a Norwood-like operation, required an ECMO. Concerns for the tube lifespan reduction due to roller pump friction led to the use of a double roller pump circulation. The termination of ECMO during tube exchange is not needed, because circulation is maintained by another roller pump. The novel strategy of ECMO with double roller pumps will allow low perfusion rate to provide adequate circulatory support for low body weight patients.

  8. Numerical Models of Human Circulatory System under Altered Gravity: Brain Circulation

    Science.gov (United States)

    Kim, Chang Sung; Kiris, Cetin; Kwak, Dochan; David, Tim

    2003-01-01

    A computational fluid dynamics (CFD) approach is presented to model the blood flow through the human circulatory system under altered gravity conditions. Models required for CFD simulation relevant to major hemodynamic issues are introduced such as non-Newtonian flow models governed by red blood cells, a model for arterial wall motion due to fluid-wall interactions, a vascular bed model for outflow boundary conditions, and a model for auto-regulation mechanism. The three-dimensional unsteady incompressible Navier-Stokes equations coupled with these models are solved iteratively using the pseudocompressibility method and dual time stepping. Moving wall boundary conditions from the first-order fluid-wall interaction model are used to study the influence of arterial wall distensibility on flow patterns and wall shear stresses during the heart pulse. A vascular bed modeling utilizing the analogy with electric circuits is coupled with an auto-regulation algorithm for multiple outflow boundaries. For the treatment of complex geometry, a chimera overset grid technique is adopted to obtain connectivity between arterial branches. For code validation, computed results are compared with experimental data for steady and unsteady non-Newtonian flows. Good agreement is obtained for both cases. In sin-type Gravity Benchmark Problems, gravity source terms are added to the Navier-Stokes equations to study the effect of gravitational variation on the human circulatory system. This computational approach is then applied to localized blood flows through a realistic carotid bifurcation and two Circle of Willis models, one using an idealized geometry and the other model using an anatomical data set. A three- dimensional anatomical Circle of Willis configuration is reconstructed from human-specific magnetic resonance images using an image segmentation method. The blood flow through these Circle of Willis models is simulated to provide means for studying gravitational effects on the brain

  9. Mechanical circulatory treatment of advanced heart failure

    DEFF Research Database (Denmark)

    Løgstrup, Brian B; Vase, Henrik; Gjedsted, Jakob;

    2016-01-01

    Heart failure is one of the most common causes of morbidity and mortality worldwide. When patients cease to respond adequately to optimal medical therapy mechanical circulatory support has been promising. The advent of mechanical circulatory support devices has allowed significant improvements...... in patient survival and quality of life for those with advanced or end-stage heart failure. We provide a general overview of current mechanical circulatory support devices encompassing options for both short- and long-term ventricular support....

  10. Short-term mechanical circulatory support by veno-arterial extracorporeal membrane oxygenation in the management of cardiogenic shock and end-stage heart failure.

    Science.gov (United States)

    Brugts, Jasper J; Caliskan, Kadir

    2014-02-01

    Despite modern treatment modalities, cardiogenic shock is associated with a very high risk of mortality and morbidity. The short- and long-term survival in patients with cardiogenic shock or end-stage heart failure has improved considerably by recent technological advances in short and long-term mechanical circulatory support devices. For short-term mechanical support, veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has been increasingly used as bridge-to-decision and bridge-to-recovery in cardiogenic shock patients. Long-term mechanical circulatory support devices such as left ventricular assist devices (LVADs) are widely available and play a central role in bridge-to-transplantation in those eligible for heart transplantation (HTX) and as destination therapy (DT) in those not eligible for heart transplantation. Nevertheless, patients with critical cardiogenic shock show a deleterious outcome after LVAD-implantation or HTX with higher mortality, more complications and higher burden on financial resources. These considerations underscore the importance of optimal timing and appropriate patient selection for eventual LVAD therapy. The current report will focus on the immediate management of patients with cardiogenic shock with inotropes, discuss the use of IABP and focus mainly on pivotal choices to be made in the period spanned by short term mechanical circulatory support in patients with refractory cardiogenic shock.

  11. [Right-sided mechanical circulatory support in acute right ventricular failure in the dog].

    Science.gov (United States)

    Gabauer, I; Okolicány, J; Styk, J; Pancza, D; Holec, V

    1991-05-01

    The technique of surgically induced acute progressive right ventricular failure in experimental animals is described. It sumultates the hemodynamic situation of right ventricular failure in some patients after termination of extracorporeal circulation applied for carrying out procedures on the left ventricle. The described technique consists of rightsided longitudinal ventriculotomy, destruction of the tricuspid valve, and ligation of the right coronary artery. Nine control dogs died within two hours after induction of failure due to low stroke volume caused by low pulmonary and left atrial pressure. The use of rightsided support appliance draining blood from the right atrium in systole and pumping it into the trunk of the pulmonary artery in diastole by means of a membrane pump resulted in further 12 dogs in the restoration of left ventricular diastolic pressure, significant increase of aortal pressure (p less than 0.003) and stroke volume (p less than 0.003) and in a decrease of right atrial pressure (p less than 0.003). The study demonstrated that by using the described mechanical support the circulation can be adequately assisted so that the failing right side of the heart can get restored. (Tab.1,Fig.5,Ref.25.).

  12. Peristaltic flow in non-uniform vessels of the micro-circulatory system

    CERN Document Server

    Maiti, S

    2013-01-01

    Of concern in the paper is generalized a theoretical study concerning the peristaltic flow of blood in the micro-circulatory system. The vessel is considered to be of non-uniform cross-section and blood to be a non-Newtonian fluid. The progressive wave front of the peristaltic flow is supposed sinusoidal/straight section dominated (SSD) (expansion/contraction type); Reynolds number is considered to be small with reference to the flow of physiological fluids. The non-Newtonian behaviour of blood is illustrated by considering the Herschel-Bulkley fluid model. The objective of the study has been to examine the effect of the effects of amplitude ratio, mean pressure gradient, yield stress and the power law index on the velocity distribution, wall shear stress, streamline pattern and trapping. Considerable quantitative differences between the results obtained for transport in two dimensional channel and an axisymmetric circular tube are noticed. The study shows that peristaltic pumping, flow velocity and wall shea...

  13. Centrifugal pump or pneumatic ventricle for short-term mechanical circulatory support?

    Science.gov (United States)

    Deleuze, P H; Liu, Y; Tixier, D; Okude, J; Leandri, J; Gouault, M; Galacteros, F; Cachera, J P; Loisance, D

    1989-05-01

    Two comparable groups of four Holstein calves were implanted with different left ventricle assist devices: the Centrimed centrifugal pump (CP) (Sarns Inc.) or the UTAH 85 VAD pneumatic ventricle (University of Utah). Operative procedure, inflow and outflow cannulae, monitoring, heparinization, were identical in both groups. No transfusion was ever required. The study was terminated after three days and autopsy was performed on the calves. Left ventricular unloading provided by both devices was complete (LVEDP less than 1 mmHg) and identical. LV bypassed flow rate was higher in CP (0.045 L/min/kg) than in UTAH 85 VAD (0.035 L/min/kg) but with no statistical difference. Blood trauma was comparable in the two groups. Daily blood samples did not show any significant changes from baseline values in creatinine, hematocrit, fibrinogen. Platelet loss from initial level was 30%; serum lactate dehydrogenase rose 150% with no significant difference in the two groups; plasma free hemoglobin never reached significant values. At autopsy, thrombotic deposits on cannuale and renal infarction rate were similar. CP housing had to be changed every day, whereas no technical failure was ever observed with the UTAH 85 VAD. Clinical response and blood damage of the two pumps used as LVAD were the same. Considering the CP has to be replaced every 24 h, the cost of three CP's would be comparable to one Utah UVAD-85 if polyurethane tricusp semi-lunar valves are used in the latter. Until the UTAH-85 VAD becomes commercially available, simple valveless low-cost CP are very attractive for short-term mechanical support.

  14. Early Results of the “Clamp and Sew” Fontan Procedure Without the Use of Circulatory Support

    Science.gov (United States)

    Shinkawa, Takeshi; Anagnostopoulos, Petros V.; Johnson, Natalie C.; Presnell, Laura; Watanabe, Naruhito; Sapru, Anil; Azakie, Anthony

    2017-01-01

    Background A modification of the Fontan operation was recently applied, which includes anastomoses of the extra-cardiac conduit to the right pulmonary artery and inferior vena cava using simple clamping with no additional circulatory support, venous shunting, pulmonary artery preparation, or prior maintenance of azygos vein patency. The objective of this study is to assess the outcomes of this novel off-pump “clamp and sew” Fontan procedure. Methods This is a retrospective review of all patients having a Fontan procedure between January 2009 and October 2010 at a single institution. Results Twelve patients had a Fontan procedure with the use of cardiopulmonary bypass (CPB group), and 12 had an off-pump Fontan procedure (off-pump group). Preoperative demographic and hemodynamic data were similar except for higher mean pulmonary artery pressure in the CPB group (12.2 ± 1.6 mm Hg versus 9.9 ± 2.4 mm Hg; p = 0.02). No patients in the off-pump group required conversion to CPB. The mean inferior vena cava clamp time in the off-pump group patients was 10 ± 3 minutes. There were no early or midterm deaths. No patients exhibited postoperative hepatic or renal dysfunction. Postoperative maximal serum creatinine and aspartate transaminase were significantly lower in the off-pump group compared with the CPB group (0.59 ± 0.12 versus 0.77 ± 0.22 mg/dL; p = 0.03 and 35.5 ± 8.3 versus 53.1 ± 19.0 U/L; p = 0.02, respectively). At median follow-up of 13 months (range, 1 to 20 months), all but 1 patient in the CPB group are in New York Heart Association class I with unobstructed Fontan circulation. Conclusions The clamp and sew technique for completion of an extracardiac conduit Fontan procedure appears safe and feasible for selected patients. PMID:21524454

  15. A LabVIEW model incorporating an open-loop arterial impedance and a closed-loop circulatory system.

    Science.gov (United States)

    Cole, R T; Lucas, C L; Cascio, W E; Johnson, T A

    2005-11-01

    While numerous computer models exist for the circulatory system, many are limited in scope, contain unwanted features or incorporate complex components specific to unique experimental situations. Our purpose was to develop a basic, yet multifaceted, computer model of the left heart and systemic circulation in LabVIEW having universal appeal without sacrificing crucial physiologic features. The program we developed employs Windkessel-type impedance models in several open-loop configurations and a closed-loop model coupling a lumped impedance and ventricular pressure source. The open-loop impedance models demonstrate afterload effects on arbitrary aortic pressure/flow inputs. The closed-loop model catalogs the major circulatory waveforms with changes in afterload, preload, and left heart properties. Our model provides an avenue for expanding the use of the ventricular equations through closed-loop coupling that includes a basic coronary circuit. Tested values used for the afterload components and the effects of afterload parameter changes on various waveforms are consistent with published data. We conclude that this model offers the ability to alter several circulatory factors and digitally catalog the most salient features of the pressure/flow waveforms employing a user-friendly platform. These features make the model a useful instructional tool for students as well as a simple experimental tool for cardiovascular research.

  16. Impella 5.0 as a Second-Line Mechanical Circulatory Support Strategy After Extracorporeal Life Support.

    Science.gov (United States)

    Schibilsky, David; Kruger, Tobias; Lausberg, Henning F; Eisenlohr, Christoph; Haller, Christoph; Nemeth, Attila; Schibilsky, Barbara; Haeberle, Helene; Rosenberger, Peter; Walker, Tobias; Schlensak, Christian

    2016-09-01

    The catheter-based Impella 5.0 left ventricular assist device is a powerful and less invasive alternative for patients in cardiogenic shock. The use as second-line therapy in patients with precedent extracorporeal life support (ECLS) has not been described before now. We analyzed our experience of consecutive patients treated with this alternative strategy. From April 2014 to December 2014, eight patients had been implanted as a second-line option after ECLS support. The reason for the change from ECLS to Impella 5.0 was absence of cardiac recovery for primary weaning and complications of ECLS therapy. The mean time of ECLS support prior to Impella implantation was 12 ± 7 days. The implantation of the Impella 5.0/CP was technically successful in all patients, and the ECLS could be explanted in all eight patients who received Impella implantation as a second-line treatment. The second-line Impella 5.0 therapy resulted in two patients who turned into left ventricular assist device (LVAD) candidates, two primary weaning candidates, and four patients who died in the setting of sepsis or absent cardiac recovery and contraindications for durable LVAD therapy. Thereby, the overall hospital discharge survival as well as the 180-day survival was 50% for Impella 5.0 implantations as second-line procedure after ECLS. The latest follow-up survival of this second-line strategy after ECLS was three out of eight, as one patient died after 299 days of LVAD support due to sepsis. The use of Impella 5.0 constitutes a possible second-line therapeutic option for those patients who do not show cardiac recovery during prolonged ECLS support or suffer from complications of ECLS therapy. This treatment allows additional time for decisions regarding cardiac recovery or indication for durable LVAD therapy.

  17. [THE CHARACTERISTIC OF SOMATOTYPE AND FUNCTIONAL STATE OF CIRCULATORY SYSTEM OF STUDENT YOUTH OF THE NORTHEAST OF RUSSIA].

    Science.gov (United States)

    Timofeieva, A V; Klimova, T M; Mikhailova, A E; Zakharova, R N; Vinokurova, S P; Timofeiev, L F

    2015-01-01

    The article considers results of single-step study in random sampling of female students of the M.K. Ammosov north-east federal university (n=456). The study was carried out to investigate somatotype and functional state of circulatory system. The standard technique was applied to measure height, body mass, chest circumference, level of arterial pressure and rate of heart beats. The type of somatotype was established using Pignet index. The tone of vegetative system was determined using Kérdö index. The adaptation potential of circulatory system was determined using functional changes index. The results of study established that in 61% of examined female students the type of constitution corresponds to normosthenic one. The percentage of persons with asthenic and hypersthenic type of constitution amounted to 27% and 12% correspondingly. The signs of increasing oftone ofsympathetic nervous system are observed in 89% of girls. The functional condition of circulatory system is evaluated as "tension of adaptation mechanisms" that is apparently related to period of adaptation to new conditions. The prolonged preservation of such states results in exhaustion offunctional resources of organism and can promote development of diseases. In conditions of impacting of unfavorable ecological factors the deconditionning disorders can significantly contribute to health disturbances and decreasing of life quality. To preserve youth's health during period of education the comprehensive strategy is to be implemented such components as dynamic monitoring of health, organization of adequate diet, explanation of necessity of observance of sleep and rest pattern, development of conditions for active aerobic physical exertion and activities on correction of risk factors of development of diseases are to be included.

  18. Mortality due to diseases of the circulatory system among the elderly population in Brazilian Amazon: temporal and spatial analysis

    Directory of Open Access Journals (Sweden)

    Karine Vila Real Nunes

    2013-12-01

    Full Text Available INTRODUCTION: Circulatory Diseases (CD are the major cause of death among the elderly population in Brazilian Amazon. OBJECTIVE: to analyze standardized mortality rates of diseases of the circulatory system (DCS, according to the main causes of death among the elderly, in microregions of the Brazilian Amazon, in the period of 1998 - 2007. METHODS: ecological study of mortality rates distribution standardized by CD and corrected by deaths from poorly defined causes among the elderly (> 65 years of age who lived in Brazilian Amazon in the period of 1998 - 2007. The analysis were carried out by the linear regression, trend, and spatial distribution of Kernel. RESULTS: We verified an increasing trend in mortality by CD (β1 = 28.34 p = 0.01, due to the increasing trend in the States of Maranhão and Tocantins. The central region of Mato Grosso, Northern Tocantins, Eastern Pará and Southwestern Maranhão present hot spots with the highest mortality rates. Males present higher rates when compared to females all over the region; rates of mortality due to acute myocardial infarction and hypertensive disease present the same spatial standard of the CD group and the rates of cerebrovascular diseases present a different spatial distribution standard. Increment in mortality rates according to age was observed: the greater the age, the higher is mortality by CD. CONCLUSION: The Brazilian Amazon presents an increasing trend with high rates of mortality by the circulatory diseases, and the geographic areas with the highest rates are around the Brazilian Amazon, in the states of Tocantins, Maranhão and Mato Grosso.

  19. Systemic activation of the transient receptor potential vanilloid subtype 4 channel causes endothelial failure and circulatory collapse: Part 2.

    Science.gov (United States)

    Willette, Robert N; Bao, Weike; Nerurkar, Sandhya; Yue, Tian-Li; Doe, Chris P; Stankus, Gerald; Turner, Gregory H; Ju, Haisong; Thomas, Heath; Fishman, Cindy E; Sulpizio, Anthony; Behm, David J; Hoffman, Sandra; Lin, Zuojun; Lozinskaya, Irina; Casillas, Linda N; Lin, Min; Trout, Robert E Lee; Votta, Bartholomew J; Thorneloe, Kevin; Lashinger, Erin S R; Figueroa, David J; Marquis, Robert; Xu, Xiaoping

    2008-08-01

    The transient receptor potential (TRP) vanilloid subtype 4 (V4) is a nonselective cation channel that exhibits polymodal activation and is expressed in the endothelium, where it contributes to intracellular Ca2+ homeostasis and regulation of cell volume. The purpose of the present study was to evaluate the systemic cardiovascular effects of GSK1016790A, a novel TRPV4 activator, and to examine its mechanism of action. In three species (mouse, rat, and dog), the i.v. administration of GSK1016790A induced a dose-dependent reduction in blood pressure, followed by profound circulatory collapse. In contrast, GSK1016790A had no acute cardiovascular effects in the TRPV4-/- null mouse. Hemodynamic analyses in the dog and rat demonstrate a profound reduction in cardiac output. However, GSK1016790A had no effect on rate or contractility in the isolated, buffer-perfused rat heart, and it produced potent endothelial-dependent relaxation of rodent-isolated vascular ring segments that were abolished by nitric-oxide synthase (NOS) inhibition (N-nitro-L-arginine methyl ester; L-NAME), ruthenium red, and endothelial NOS (eNOS) gene deletion. However, the in vivo circulatory collapse was not altered by NOS inhibition (L-NAME) or eNOS gene deletion but was associated with (concentration and time appropriate) profound vascular leakage and tissue hemorrhage in the lung, intestine, and kidney. TRPV4 immunoreactivity was localized in the endothelium and epithelium in the affected organs. GSK1016790A potently induced rapid electrophysiological and morphological changes (retraction/condensation) in cultured endothelial cells. In summary, inappropriate activation of TRPV4 produces acute circulatory collapse associated with endothelial activation/injury and failure of the pulmonary microvascular permeability barrier. It will be important to determine the role of TRPV4 in disorders associated with edema and microvascular congestion.

  20. The human heart and the circulatory system as an interesting interdisciplinary topic in lessons of physics and biology

    Science.gov (United States)

    Volná, M.; Látal, F.; Kubínek, R.; Richterek, L.

    2014-01-01

    Many topics which are closely related can be found in the national curriculum of the Czech Republic for physics and biology. One of them is the heart and the circulatory system in the human body. This topic was examined cross curriculum, a teaching module was created and the topic was chosen for our research. The task was to determine if the students of bachelor study are aware of connections between physics and biology within this topic and whether we can help them effectively to describe the corresponding physics phenomena in the human body connected, for example, with a heart attack or with the measurement of blood pressure. In this paper, the heart and the circulatory system are presented as suitable topics for an interdisciplinary teaching module which includes both theoretical and experimental parts. The module was evaluated by a group of first-year undergraduate students of physics at the Faculty of Science, Palacký University. The acquired knowledge was compared with another control group through a test. The highest efficiency of the module was evaluated on the basis of questions that covered the calculation problems.

  1. NASA Models of Space Radiation Induced Cancer, Circulatory Disease, and Central Nervous System Effects

    Science.gov (United States)

    Cucinotta, Francis A.; Chappell, Lori J.; Kim, Myung-Hee Y.

    2013-01-01

    The risks of late effects from galactic cosmic rays (GCR) and solar particle events (SPE) are potentially a limitation to long-term space travel. The late effects of highest concern have significant lethality including cancer, effects to the central nervous system (CNS), and circulatory diseases (CD). For cancer and CD the use of age and gender specific models with uncertainty assessments based on human epidemiology data for low LET radiation combined with relative biological effectiveness factors (RBEs) and dose- and dose-rate reduction effectiveness factors (DDREF) to extrapolate these results to space radiation exposures is considered the current "state-of-the-art". The revised NASA Space Risk Model (NSRM-2014) is based on recent radio-epidemiology data for cancer and CD, however a key feature of the NSRM-2014 is the formulation of particle fluence and track structure based radiation quality factors for solid cancer and leukemia risk estimates, which are distinct from the ICRP quality factors, and shown to lead to smaller uncertainties in risk estimates. Many persons exposed to radiation on earth as well as astronauts are life-time never-smokers, which is estimated to significantly modify radiation cancer and CD risk estimates. A key feature of the NASA radiation protection model is the classification of radiation workers by smoking history in setting dose limits. Possible qualitative differences between GCR and low LET radiation increase uncertainties and are not included in previous risk estimates. Two important qualitative differences are emerging from research studies. The first is the increased lethality of tumors observed in animal models compared to low LET radiation or background tumors. The second are Non- Targeted Effects (NTE), which include bystander effects and genomic instability, which has been observed in cell and animal models of cancer risks. NTE's could lead to significant changes in RBE and DDREF estimates for GCR particles, and the potential

  2. Long-term allergen exposure induces adipose tissue inflammation and circulatory system injury.

    Science.gov (United States)

    Jung, Chien-Cheng; Su, Huey-Jen

    2016-05-01

    The purpose of this study was to study whether allergen exposure can induce inflammation and lower the anti-inflammation levels in serum and in adipose tissues, and further develop cardiovascular injury. Our data showed that heart rate was significantly higher in the OVA-challenged mice compared to control mice. Moreover, there were higher expressions of pro-inflammation genes in the OVA-challenged mice in adipose tissues, and the expressions of anti-inflammation genes were lower. The levels of inflammation mediators were associated in serum and adipose tissues. The level of circulatory injury lactate dehydrogenase was significantly associated with the levels of E-selectin, resistin and adiponectin in the serum. The hematoxylin and eosin and immunohistochemistry stains indicated the OVA-challenged mice had higher levels of inflammation. In summary, the current study demonstrated allergen exposure can cause cardiovascular injury, and inflammatory mediators in adipose tissues play an important role in the pathogenesis of cardiovascular injury.

  3. Adapting MRI systems to propel and guide microdevices in the human blood circulatory system.

    Science.gov (United States)

    Martel, S; Mathieu, J B; Felfoul, O; Macicior, H; Beaudoin, G; Soulez, G; Yahia, L H

    2004-01-01

    Magnetic resonance imaging (MRI) systems are widely used to gather noninvasively images of the interior of the human body. This paper suggests that an MRI system can be seen beyond being just a tool for imaging purpose but one that can propel and guide special microdevices in the human body to perform specific medical tasks. More specifically, an MRI system can potentially be used to image the region of interest, propel a microdevice through the generation of magnetic gradients, determine the location of the device, compute the corrective actions through feedback control algorithms and adjust the generation of the magnetic gradients accordingly to navigate such a microdevice in a preplanned path. This paper presents an introductory description of the proposed techniques, the main issues to consider, and some preliminary data indicating the validity of this approach.

  4. THE IMPACT OF THE CONCEPT MAPS USED FOR OUR CIRCULATORY SYSTEM ON STUDENTS ACADEMIC SUCCESS

    Directory of Open Access Journals (Sweden)

    Mürşet ÇAKMAK

    2012-06-01

    Full Text Available This study is aimed to investigate effects of teaching “Our Circulatory System”, which is one of the subjects in Science Technology Education curriculum, with concept maps on learning level of students comparing with the traditional methods. The study was carried out in a primary school in Diyarbakır, in 2011, and it is an experimental study with a pre-post test control group. The test group included 80 (N=80 6th year students. Control group was taught using the traditional methods while test-group was trained with the concept maps. Data was collected using achievement test, which has 32 items and of which reliability co-efficient was 0,79. Research period lasted 5 weeks. The data collected was evaluated using SPSS-17. T-test analytical techniques were used to analyse. The significance level was considered as 0.05. As a result, teaching with the concept maps was found to affect students’ academic success at significant level. Some suggestions were made in the light of outcomes.

  5. Critical heart disease and mechanical circulatory support%重症心脏与心脏机械辅助装置:现状与未来

    Institute of Scientific and Technical Information of China (English)

    孙仁华; 刘景全

    2016-01-01

    机械循环支持(mechanical circulatory support,MCS)已广泛应用于ICU心源性休克及重度心力衰竭患者的救治,为心脏功能恢复的过渡发挥着重要的作用,可纠正患者的血流动力学状态,保障组织灌注,提高生存率。目前,对于MCS应用于重症心脏领域仍有很多值得进一步探索问题,如MCS适应证、应用时机及应用效果等,有待大规模临床研究验证。近年来MCS领域取得了令人欣喜的进步,如小型便携式心脏泵。未来MCS发展方向是体积小、微创、置入和撤离方便、组织相容性好及辅助效果确切。%Mechanical circulatory support (MCS) plays an important role in the treatment of cardiogenic shock and heart failure in the ICU. It is able to correct hemodynamic disorders, improve tissue perfusion and increase survival rate. But problems exist in the application of MCS in patients with critical heart disease including its indications, timing and effect, and RCTs are needed. Remarkable achievements have been made in MCS such as the application of small, portable heart pump. In future, MCS would be smaller, minimally invasive, convenient for placement and removal, and have better histocompatibility and auxiliary effectiveness.

  6. A fast building and effective hydraulic pediatric mock circulatory system for the evaluation of a left ventricular assist device.

    Science.gov (United States)

    Huang, Feng; Ruan, Xiaodong; Zou, Jun; Qian, Wenwei; Fu, Xin

    2013-01-01

    A mock circulatory system (MCS) has been proven a useful tool in the development of a ventricular assist device. Nowadays a MCS aimed at the evaluation of pediatric blood pumps, which require many different considerations compared with that of adults, has become an urgent need. This article presents the details on how the dynamic process of the left ventricle, which is described in terms of the pressure-volume loop (P-V loop), and the properties of the circulation such as compliance and resistance are simulated by hydraulic elements. A simple control method is introduced to reproduce the physiological afterload and preload sensitivities of the mock ventricle for the first time. Hemodynamic performance of the system is obtained by medical sensors to validate the similarity of the device to the native cardiovascular system. The actual sensitivities of the mock ventricle are obtained intuitively from the changes of the P-V loops. The aortic input impedance of the MCS is also obtained and compared with the data from previous medical reports. At last a pediatric left ventricular assist device (LVAD) prototype is introduced for testing to further verify the effectiveness of the MCS. The experimental results indicate that this pediatric MCS is capable of reproducing basic hemodynamic characteristics of a child in both normal and pathological conditions and it is sufficient for testing a pediatric LVAD. Besides, most components constituting the main hydraulic part of this MCS are inexpensive off-the-shelf products, making the MCS easy and fast to build.

  7. Life expectancy and death by diseases of the circulatory system in patients with bipolar disorder or schizophrenia in the Nordic countries

    DEFF Research Database (Denmark)

    Laursen, Thomas Munk; Wahlbeck, Kristian; Hällgren, Jonas;

    2013-01-01

    Excess mortality from diseases and medical conditions (natural death) in persons with psychiatric disorders has been extensively reported. Even in the Nordic countries with well-developed welfare systems, register based studies find evidence of an excess mortality. In recent years, cardiac...... mortality and death by diseases of the circulatory system has seen a decline in all the Nordic countries, but a recent paper indicates that women and men in Denmark, Finland, and Sweden, who had been hospitalised for a psychotic disorder, had a two to three-fold increased risk of dying from a cardiovascular...... disease. The aim of this study was to compare the mortality by diseases of the circulatory system among patients with bipolar disorder or schizophrenia in the three Nordic countries Denmark, Sweden, and Finland. Furthermore, the aim was to examine and compare life expectancy among these patients. Cause...

  8. A new method of providing pulsatile flow in a centrifugal pump: assessment of pulsatility using a mock circulatory system.

    Science.gov (United States)

    Herreros, Jesús; Berjano, Enrique J; Sales-Nebot, Laura; Más, Pedro; Calvo, Irene; Mastrobuoni, Stefano; Mercé, Salvador

    2008-06-01

    Previous studies have demonstrated the potential advantages of pulsatile flow as compared with continuous flow. However, to date, physiologic pumps have been technically complex and their application has therefore remained in the experimental field. We have developed a new type of centrifugal pump, which can provide pulsatile as well as continuous flow. The inner wall of a centrifugal pump is pulsed by means of a flexible membrane, which can be accurately controlled by means of either a hydraulic or pneumatic driver. The aim of this study was to assess the hydraulic behavior of the new pump in terms of surplus hemodynamic energy (SHE). We conducted experiments using a mock circulatory system including a membrane oxygenator. No differences were found in the pressure-flow characteristics between the new pump and a conventional centrifugal pump, suggesting that the inclusion of the flexible membrane does not alter hydraulic performance. The value of SHE rose when systolic volume was increased. However, SHE dropped when the percentage of ejection time was reduced and also when the continuous flow (programmed by the centrifugal console) increased. Mean flow matched well with the continuous flow set by the centrifugal console, that is, the pulsatile component of the flow was exclusively controlled by the pulsatile console, and was therefore independent of the continuous flow programmed by the centrifugal console. The pulsatility of the new pump was approximately 25% of that created with a truly pulsatile pump.

  9. Progression of Mortality due to Diseases of the Circulatory System and Human Development Index in Rio de Janeiro Municipalities

    Science.gov (United States)

    Soares, Gabriel Porto; Klein, Carlos Henrique; Silva, Nelson Albuquerque de Souza e; de Oliveira, Glaucia Maria Moraes

    2016-01-01

    Background Diseases of the circulatory system (DCS) are the major cause of death in Brazil and worldwide. Objective To correlate the compensated and adjusted mortality rates due to DCS in the Rio de Janeiro State municipalities between 1979 and 2010 with the Human Development Index (HDI) from 1970 onwards. Methods Population and death data were obtained in DATASUS/MS database. Mortality rates due to ischemic heart diseases (IHD), cerebrovascular diseases (CBVD) and DCS adjusted by using the direct method and compensated for ill-defined causes. The HDI data were obtained at the Brazilian Institute of Applied Research in Economics. The mortality rates and HDI values were correlated by estimating Pearson linear coefficients. The correlation coefficients between the mortality rates of census years 1991, 2000 and 2010 and HDI data of census years 1970, 1980 and 1991 were calculated with discrepancy of two demographic censuses. The linear regression coefficients were estimated with disease as the dependent variable and HDI as the independent variable. Results In recent decades, there was a reduction in mortality due to DCS in all Rio de Janeiro State municipalities, mainly because of the decline in mortality due to CBVD, which was preceded by an elevation in HDI. There was a strong correlation between the socioeconomic indicator and mortality rates. Conclusion The HDI progression showed a strong correlation with the decline in mortality due to DCS, signaling to the relevance of improvements in life conditions. PMID:27849263

  10. Stagnation point flow and heat transfer on a thin porous sheet: Applications to flow dynamics of the circulatory system

    Science.gov (United States)

    Misra, J. C.; Sinha, A.; Mallick, B.

    2017-03-01

    The paper is concerned with the modeling and analysis of stagnation point flow and heat transfer on a thin porous sheet under the action of an induced magnetic field. The fluid is considered to be incompressible viscous and electrically conducting. The study is motivated towards exploring some interesting phenomena in the micro-circulatory system. Heat transfer is considered to be governed by the heat equation. In order to take care of the induced magnetism that affects the flow process, the flow equations are coupled with magnetic field variables. The analysis has been performed under the purview of the boundary layer theory, together with the use of similarity transformation. The transformed equations are solved by developing an appropriate numerical method. Numerical results have been computed for a typical situation of the fluid in motion. The results are displayed graphically/in tabular form, which depict the distribution of velocity and temperature under the action of the induced magnetic field and permeability of the porous sheet. The study shows that the flow of the fluid reduces, as the strength of the induced magnetic field increases. However, the reduction in velocity is accompanied by an enhancement of the temperature field.

  11. MedTech Mag-Lev, single-use, extracorporeal magnetically levitated centrifugal blood pump for mid-term circulatory support.

    Science.gov (United States)

    Nagaoka, Eiki; Fujiwara, Tatsuki; Kitao, Takashi; Sakota, Daisuke; Shinshi, Tadahiko; Arai, Hirokuni; Takatani, Setsuo

    2013-01-01

    Short- to mid-term extracorporeal ventricular assist devices (VADs) are recommended for critical cardiogenic shock patients. We have designed a preclinical, single-use MedTech Mag-Lev VAD for one-month extracorporeal use. The impeller-rotor of the pump was suspended by a two degree-of-freedom active magnetic bearing in a 300 μm fluid gap, where the computational fluid dynamics analysis predicted a secondary flow of about 400-500 ml/min at a pump speed of 1800-2200 rpm. Three eddy current sensors were employed to implement noise- and drift-free magnetic levitation. The pump components were injection molded using polycarbonate for smooth surfaces as well as improved reproducibility, followed by coating with a biocompatible 2-methacryloyl-oxyethyl phosphorylcholine polymer. Chronic animal experiments were performed in nine calves. Three of the nine calves were excluded from analysis for problems with the circuit. Five of the six (83.3%) completed the 60 day duration of the study, while one prematurely died of massive bleeding due to inflow port detachment. The pump did not stop due to magnetic-levitation malfunction. Neither pump thrombosis nor major organ infarction was observed at autopsy. In comparison to machined surfaces, the injection-molded pump surfaces were thrombus-free after 60 day implantation. This study demonstrates the feasibility of MedTech Mag-Lev VAD for 60 day circulatory support.

  12. Clinical trial design and rationale of the Multicenter Study of MagLev Technology in Patients Undergoing Mechanical Circulatory Support Therapy With HeartMate 3 (MOMENTUM 3) investigational device exemption clinical study protocol.

    Science.gov (United States)

    Heatley, Gerald; Sood, Poornima; Goldstein, Daniel; Uriel, Nir; Cleveland, Joseph; Middlebrook, Don; Mehra, Mandeep R

    2016-04-01

    The HeartMate 3 left ventricular assist system (LVAS; St. Jude Medical, Inc., formerly Thoratec Corporation, Pleasanton, CA) was recently introduced into clinical trials for durable circulatory support in patients with medically refractory advanced-stage heart failure. This centrifugal, fully magnetically levitated, continuous-flow pump is engineered with the intent to enhance hemocompatibility and reduce shear stress on blood elements, while also possessing intrinsic pulsatility. Although bridge-to-transplant (BTT) and destination therapy (DT) are established dichotomous indications for durable left ventricular assist device (LVAD) support, clinical practice has challenged the appropriateness of these designations. The introduction of novel LVAD technology allows for the development of clinical trial designs to keep pace with current practices. The prospective, randomized Multicenter Study of MagLev Technology in Patients Undergoing Mechanical Circulatory Support Therapy With HeartMate 3 (MOMENTUM 3) clinical trial aims to evaluate the safety and effectiveness of the HeartMate 3 LVAS by demonstrating non-inferiority to the HeartMate II LVAS (also St. Jude Medical, Inc.). The innovative trial design includes patients enrolled under a single inclusion and exclusion criteria , regardless of the intended use of the device, with outcomes ascertained in the short term (ST, at 6 months) and long term (LT, at 2 years). This adaptive trial design includes a pre-specified safety phase (n = 30) analysis. The ST cohort includes the first 294 patients and the LT cohort includes the first 366 patients for evaluation of the composite primary end-point of survival to transplant, recovery or LVAD support free of debilitating stroke (modified Rankin score >3), or re-operation to replace the pump. As part of the adaptive design, an analysis by an independent statistician will determine whether sample size adjustment is required at pre-specified times during the study. A further 662

  13. [The influence of the length of work on the adaptation of the circulatory system of male teachers of different specialities].

    Science.gov (United States)

    Kirilina, V M; Goranskiĭ, A I

    2010-01-01

    The problem of human adaptation to the social and biological conditions of the existence is placed at the center of attention of many natural and social sciences studying vital activity of a person in all forms it displays. The basis of the existence of the human population is considered to be a social and labor activity of people. Recently, the importance of researches has increased, which enables to evaluate the functional state of a person under the circumstances of adaptation to a particular occupation. These researches are the theoretical foundation to develop methods for improving the efficiency of people in many kinds of professions, and especially it is important for elderly people. The results of social and hygienic researches among the middle-aged and elderly people involved in different trades vary and are stipulated generally by the conditions of the working environment, difficulties and intensity of work processes. The study of the features of the circulatory system of a person in the process of working activities is a significant issue in physiology. It is found that the greatest changes in the functional parameters of the blood circulation are observed in young and elderly people. In the same way, it is shown that it depends on the type of adaptation, age characteristics, work experience which result in slowing down the rate of the processes of the nervous system, the regulation of blood circulation becomes inert, the level of physical health reduces, and age displacements accelerate. These changes are considered as a result of increased spending of physiological reserves of the organism in various environmental conditions.

  14. Influence of Mechanical Circulatory Support on Endothelin Receptor Expression in Human Left Ventricular Myocardium from Patients with Dilated Cardiomyopathy (DCM)

    Science.gov (United States)

    Gärtner, Florian; Abraham, Getu; Kassner, Astrid; Baurichter, Daniela; Milting, Hendrik

    2017-01-01

    Background In terminal failing hearts ventricular assist devices (VAD) are implanted as a bridge to transplantation. Endothelin receptor (ETR) antagonists are used for treatment of secondary pulmonary hypertension in VAD patients. However, the cardiac ETR regulation in human heart failure and during VAD support is incompletely understood. Methods In paired left ventricular samples of 12 dilated cardiomyopathy patients we investigated the density of endothelin A (ETA) and B (ETB) receptors before VAD implantation and after device removal. Left ventricular samples of 12 non-failing donor hearts served as control. Receptor quantification was performed by binding of [125I]-ET-1 in the presence of nonselective and ETA selective ETR ligands as competitors. Additionally, the ETR mRNA expression was analyzed using quantitative real-time-PCR. Results The mRNA of ETA but not ETB receptors was significantly elevated in heart failure, whereas total ETR density analyzed by radioligand binding was significantly reduced due to ETB receptor down regulation. ETA and ETB receptor density showed poor correlation to mRNA data (spearman correlation factor: 0.43 and 0.31, respectively). VAD support had no significant impact on the density of both receptors and on mRNA expression of ETA whereas ETB mRNA increased during VAD. A meta-analysis reveals that the ETA receptor regulation in human heart failure appears to depend on non-failing hearts. Conclusions In deteriorating hearts of patients suffering from dilated cardiomyopathy the ETA receptor density is not changed whereas the ETB receptor is down regulated. The mRNA and the proteins of ETA and ETB show a weak correlation. Non-failing hearts might influence the interpretation of ETA receptor regulation. Mechanical unloading of the failing hearts has no impact on the myocardial ETR density. PMID:28095452

  15. System analysis of changes in cardiovascular circulatory dynamics in experimental diphtheria in rabbit.

    Science.gov (United States)

    Zotov, A K; Frolov, V A; Zotova, T J

    2009-09-01

    Trivariate correlation analysis of hemodynamic indices of the cardiovascular system in rabbits with diphtheria showed that adaptation of this system to direct action of diphtherin can be visualized by analysis of trivariate correlation tightness for indices of intraventricular pressure in the left and right ventricles and indices of systemic blood pressure. Using empirical production functions for systemic blood pressure indices we found that the contribution of intraventricular pressure in the left and right ventricles on blood pressure values is changed in diphtheria compared to the control. Basing on entropy analysis we established that the regimen of control over values of working intraventricular pressure in both left and right ventricles in diphtheria is changed from quasidetermined to stochastic.

  16. On the destabilizing effect of damping on discrete and continuous circulatory systems

    Science.gov (United States)

    Luongo, Angelo; D`Annibale, Francesco

    2014-12-01

    The 'Ziegler paradox', concerning the destabilizing effect of damping on elastic systems loaded by nonconservative positional forces, is addressed. The paper aims to look at the phenomenon in a new perspective, according to which no surprising discontinuities in the critical load exist between undamped and damped systems. To show that the actual critical load is found as an (infinitesimal) perturbation of one of the infinitely many sub-critically loaded undamped systems. A series expansion of the damped eigenvalues around the distinct purely imaginary undamped eigenvalues is performed, with the load kept as a fixed, although unknown, parameter. The first sensitivity of the eigenvalues, which is found to be real, is zeroed, so that an implicit expression for the critical load multiplier is found, which only depends on the 'shape' of damping, being independent of its magnitude. An interpretation is given of the destabilization paradox, by referring to the concept of 'modal damping', according to which the sign of the projection of the damping force on the eigenvector of the dual basis, and not on the eigenvector itself, is the true responsible for stability. The whole procedure is explained in detail for discrete systems, and successively extended to continuous systems. Two sample structures are studied for illustrative purposes: the classical reverse double-pendulum under a follower force and a linear visco-elastic beam under a follower force and a dead load.

  17. Signaling at the cell surface in the circulatory and ventilatory systems

    CERN Document Server

    Thiriet, Marc

    2012-01-01

    The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 3 is devoted to the set of mediators of the cell surface, especially ion and molecular carriers and catalytic receptors that, once liganded and activated, initiat...

  18. 77 FR 16038 - Circulatory System Devices Panel of the Medical Devices Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2012-03-19

    ... by HeartWare, Inc. The HVAS is an implantable electrically powered centrifugal-flow rotary blood pump... require the creation of an abdominal pump pocket. The HVAS is indicated for use as a bridge to cardiac... Subcutaneous Implantable Cardioverter Defibrillator (S-ICD) System sponsored by Cameron Health, Inc. The...

  19. Assessment of a continuous blood gas monitoring system in animals during circulatory stress

    Directory of Open Access Journals (Sweden)

    Renzulli Attilio

    2011-01-01

    Full Text Available Abstract Background The study was aimed to determine the measurement accuracy of The CDI™ blood parameter monitoring system 500 (Terumo Cardiovascular Systems Corporation, Ann Arbor MI in the real-time continuous measurement of arterial blood gases under different cardiocirculatory stress conditions Methods Inotropic stimulation (Dobutamine 2.5 and 5 μg/kg/min, vasoconstriction (Arginine-vasopressin 4, 8 and 16 IU/h, hemorrhage (-10%, -20%, -35%, and -50% of the theoretical volemia, and volume resuscitation were induced in ten swine (57.4 ± 10.7 Kg.Intermittent blood gas assessments were carried out using a routine gas analyzer at any experimental phase and compared with values obtained at the same time settings during continuous monitoring with CDI™ 500 system. The Bland-Altman analysis was employed. Results Bias and precision for pO2 were - 0.06 kPa and 0.22 kPa, respectively (r2 = 0.96; pCO2 - 0.02 kPa and 0.15 kPa, respectively; pH -0.001 and 0.01 units, respectively ( r2 = 0.96. The analysis showed very good agreement for SO2 (bias 0.04,precision 0.33, r2 = 0.95, Base excess (bias 0.04,precision 0.28, r2 = 0.98, HCO3 (bias 0.05,precision 0.62, r2 = 0.92,hemoglobin (bias 0.02,precision 0.23, r2 = 0.96 and K+ (bias 0.02, precision 0.27, r2 = 0.93. The sensor was reliable throughout the experiment during hemodynamic variations. Conclusions Continuous blood gas analysis with the CDI™ 500 system was reliable and it might represent a new useful tool to accurately and timely monitor gas exchange in critically ill patients. Nonetheless, our findings need to be confirmed by larger studies to prove its reliability in the clinical setting.

  20. In vivo 3D visualization of peripheral circulatory system using linear optoacoustic array

    Science.gov (United States)

    Ermilov, Sergey A.; Brecht, Hans-Peter; Fronheiser, Matthew P.; Nadvoretsky, Vyacheslav; Su, Richard; Conjusteau, Andre; Oraevsky, Alexander A.

    2010-02-01

    In this work we modified light illumination of the laser optoacoustic (OA) imaging system to improve the 3D visualization of human forearm vasculature. The computer modeling demonstrated that the new illumination design that features laser beams converging on the surface of the skin in the imaging plane of the probe provides superior OA images in comparison to the images generated by the illumination with parallel laser beams. We also developed the procedure for vein/artery differentiation based on OA imaging with 690 nm and 1080 nm laser wavelengths. The procedure includes statistical analysis of the intensities of OA images of the neighboring blood vessels. Analysis of the OA images generated by computer simulation of a human forearm illuminated at 690 nm and 1080 nm resulted in successful differentiation of veins and arteries. In vivo scanning of a human forearm provided high contrast 3D OA image of a forearm skin and a superficial blood vessel. The blood vessel image contrast was further enhanced after it was automatically traced using the developed software. The software also allowed evaluation of the effective blood vessel diameter at each step of the scan. We propose that the developed 3D OA imaging system can be used during preoperative mapping of forearm vessels that is essential for hemodialysis treatment.

  1. Mechanical circulatory devices in acute heart failure.

    Science.gov (United States)

    Teuteberg, Jeffrey J; Chou, Josephine C

    2014-07-01

    Cardiogenic shock remains a leading cause of mortality despite advances in the treatment of myocardial infarction and advanced heart failure. Medical therapy can be inadequate, and patients may need mechanical circulatory support (MCS). The proper application of MCS requires knowledge of the underlying cause of acute heart failure, familiarity with the circulatory support devices, and the potential benefits and limitations of device therapy. This article describes the most commonly used temporary ventricular assist devices and their use in the various causes of cardiogenic shock.

  2. Numerical modeling of the fetal blood flow in the placental circulatory system

    Science.gov (United States)

    Shannon, Alexander; Gallucci, Sergio; Mirbod, Parisa

    2015-11-01

    The placenta is a unique organ of exchange between the growing fetus and the mother. It incorporates almost all functions of the adult body, acting as the fetal lung, digestive and immune systems, to mention a few. The exchange of oxygen and nutrients takes place at the surface of the villous tree. Using an idealized geometry of the fetal villous trees in the mouse placenta, in this study we performed 3D computational analysis of the unsteady fetal blood flow, gas, and nutrient transport over the chorionic plate. The fetal blood was treated as an incompressible Newtonian fluid, and the oxygen and nutrient were treated as a passive scalar dissolved in blood plasma. The flow was laminar, and a commercial CFD code (COMSOL Multiphysics) has been used for the simulation. COMSOL has been selected because it is multi-physics FEM software that allows for the seamless coupling of different physics represented by partial differential equations. The results clearly illustrate that the specific branching pattern and the in-plane curvature of the fetal villous trees affect the delivery of blood, gas and nutrient transport to the whole placenta.

  3. The influence of the winter North Atlantic Oscillation index on hospital admissions through diseases of the circulatory system in Lisbon, Portugal

    Science.gov (United States)

    Almendra, Ricardo; Santana, Paula; Vasconcelos, João; Silva, Giovani; Gonçalves, Fábio; Ambrizzi, Tércio

    2016-07-01

    The aim of this paper is to analyze the relationship between North Atlantic Oscillation (NAO), meteorological variables, air pollutants, and hospital admissions due to diseases of circulatory systems in Lisbon (Portugal) during winter months (2003-2012). This paper is one of the few studies analyzing the impact of NAO on health through its influence on thermal stress and air pollution and is the first to be conducted in Lisbon. This study uses meteorological data (synthetized into a thermal comfort index), air pollutant metrics, and the NAO index (all clustered in 10-day cycles to overcome daily variability of the NAO index). The relationship between morbidity, thermal comfort index, NAO index, and air pollutants was explored through several linear models adjusted to seasonality through a periodic function. The possible indirect effect between the NAO index and hospital admissions was tested, assuming that NAO (independent variable) is affecting hospital admissions (outcome variable) through thermal discomfort and/or pollution levels (tested as individual mediators). This test was conducted through causal mediation analysis and adjusted for seasonal variation. The results from this study suggest a possible indirect relationship between NAO index and hospital admissions. Although NAO is not significantly associated with hospital admissions, it is significantly associated with CO, PM2.5, NO, and SO2 levels, which in turn increase the probability of hospitalization. The discomfort index (built with temperature and relative humidity) is significantly associated with hospital admissions, but its variability is not explained by the NAO index. This study highlights the impacts of the atmospheric circulation patterns on health. Furthermore, understanding the influence of the atmospheric circulation patterns can support the improvement of the existing contingency plans.

  4. The influence of the winter North Atlantic Oscillation index on hospital admissions through diseases of the circulatory system in Lisbon, Portugal

    Science.gov (United States)

    Almendra, Ricardo; Santana, Paula; Vasconcelos, João; Silva, Giovani; Gonçalves, Fábio; Ambrizzi, Tércio

    2017-02-01

    The aim of this paper is to analyze the relationship between North Atlantic Oscillation (NAO), meteorological variables, air pollutants, and hospital admissions due to diseases of circulatory systems in Lisbon (Portugal) during winter months (2003-2012). This paper is one of the few studies analyzing the impact of NAO on health through its influence on thermal stress and air pollution and is the first to be conducted in Lisbon. This study uses meteorological data (synthetized into a thermal comfort index), air pollutant metrics, and the NAO index (all clustered in 10-day cycles to overcome daily variability of the NAO index). The relationship between morbidity, thermal comfort index, NAO index, and air pollutants was explored through several linear models adjusted to seasonality through a periodic function. The possible indirect effect between the NAO index and hospital admissions was tested, assuming that NAO (independent variable) is affecting hospital admissions (outcome variable) through thermal discomfort and/or pollution levels (tested as individual mediators). This test was conducted through causal mediation analysis and adjusted for seasonal variation. The results from this study suggest a possible indirect relationship between NAO index and hospital admissions. Although NAO is not significantly associated with hospital admissions, it is significantly associated with CO, PM2.5, NO, and SO2 levels, which in turn increase the probability of hospitalization. The discomfort index (built with temperature and relative humidity) is significantly associated with hospital admissions, but its variability is not explained by the NAO index. This study highlights the impacts of the atmospheric circulation patterns on health. Furthermore, understanding the influence of the atmospheric circulation patterns can support the improvement of the existing contingency plans.

  5. Magnetic support system

    NARCIS (Netherlands)

    Nijsse, G.J.P.; Spronck, J.W.

    1999-01-01

    There is described a support system enabling supporting an object such as a platform (1) free from vibration, in that bearing elements (50) have a stiffness (k) which at a working point (z0) equals zero. A bearing element (50) comprises two magnetic couplings (51, 52) provided by permanent magnets (

  6. Association of sulfur dioxide exposure with circulatory system deaths in a medium-sized city in Brazil

    Directory of Open Access Journals (Sweden)

    C.T. Amancio

    2012-11-01

    Full Text Available There is a demonstrable association between exposure to air pollutants and deaths due to cardiovascular diseases. The objective of this study was to estimate the effects of exposure to sulfur dioxide on mortality due to circulatory diseases in individuals 50 years of age or older residing in São José dos Campos, SP. This was a time-series ecological study for the years 2003 to 2007 using information on deaths due to circulatory disease obtained from Datasus reports. Data on daily levels of pollutants, particulate matter, sulfur dioxide (SO2, ozone, temperature, and humidity were obtained from the São Paulo State Environmental Agency. Moving average models for 2 to 7 days were calculated by Poisson regression using the R software. Exposure to SO2 was analyzed using a unipollutant, bipollutant or multipollutant model adjusted for mean temperature and humidity. The relative risks with 95%CI were obtained and the percent decrease in risk was calculated. There were 1928 deaths with a daily mean (± SD of 1.05 ± 1.03 (range: 0-6. Exposure to SO2 was significantly associated with mortality due to circulatory disease: RR = 1.04 (95%CI = 1.01 to 1.06 in the 7-day moving average, after adjusting for ozone. There was an 8.5% decrease in risk in the multipollutant model, proportional to a decrease of SO2 concentrations. The results of this study suggest that residents of medium-sized Brazilian cities with characteristics similar to those of São José dos Campos probably have health problems due to exposure to air pollutants.

  7. Transfusion associated circulatory overload

    Directory of Open Access Journals (Sweden)

    Naveen Agnihotri

    2014-01-01

    Full Text Available Transfusion associated circulatory overload (TACO is an established, but grossly under diagnosed and underreported complication of blood transfusion. We present the case of a 46-year-old diabetic and hypertensive patient admitted to our hospital for recurrent episodes of urinary retention. Over initial 3 days of the admission, the patient received multiple units of packed red blood cells (RBC and fresh frozen plasma, uneventfully. However, the patient developed signs and symptoms suggestive of TACO with only small amount of the 4 th unit of RBC. The patient had to be shifted to the Intensive Care Unit for further management of this complication. Etiology of TACO is more complex than a mere circulatory overload and is still not completely understood. TACO leads to a prolonged hospital stay and morbidity in the patients developing this complication. TACO thus needs to be suspected in patients at risk for this complication.

  8. The first organ-based free ontology for arthropods (Ontology of Arthropod Circulatory Systems - OArCS) and its integration into a novel formalization scheme for morphological descriptions.

    Science.gov (United States)

    Wirkner, Christian S; Göpel, Torben; Runge, Jens; Keiler, Jonas; Klussmann-Fricke, Bastian-Jesper; Huckstorf, Katarina; Scholz, Stephan; Mikó, Istvan; Yoder, Matt; Richter, Stefan

    2017-01-25

    Morphology, the oldest discipline in the biosciences, is currently experiencing a renaissance in the field of comparative phenomics. However, morphological/phenotypic research still suffers on various levels from a lack of standards. This shortcoming, first highlighted as the "linguistic problem of morphology", concerns the usage of terminology but also the need for formalization of morphological descriptions themselves, something of paramount importance not only to the field of morphology but also when it comes to the use of phenotypic data in systematics and evolutionary biology. We therefore argue, that for morphological descriptions, the basis of all systematic and evolutionary interpretations, ontologies need to be utilized which are based exclusively on structural qualities/properties and which in no case include statements about homology and/or function. Statements about homology and function constitute interpretations on a different or higher level. Based on these 'anatomy ontologies', further ontological dimensions (e.g. referring to functional properties or homology) may be exerted for a broad use in evolutionary phenomics. To this end we present the first organ-based ontology for the most species-rich animal group, the Arthropoda. Our Ontology of Arthropod Circulatory Systems (OArCS) contains a comprehensive collection of 383 terms (i.e. sups) tied to 296 concepts (i.e. definitions) collected from the literature on phenotypic aspects of circulatory organ features in arthropods. All of the concepts used in OArCS are based exclusively on structural features, and in the context of the ontology are independent of homology and functional assumptions. We cannot rule out that in some cases, terms are used which in traditional usage and previous accounts might have implied homology and/or function, e.g. heart, sternal artery. Concepts are composed of descriptive elements that are used to classify observed instances into the organizational framework of the

  9. Indirectly Measuring Aortic Flow in a Mock Circulatory System%模拟循环系统中的主动脉流间接测量

    Institute of Scientific and Technical Information of China (English)

    黄欢; 杨明; 邬顺捷

    2012-01-01

    In mock circulatory systems, the aortic flow is of violent pulsation. Measuring this signal direct-ly with flow meter will limit its applications to mimic different physiological objects, considering the effects of diameter and wall thickness of the tube, the measurement range of flow meters, etc. In order to solve these problems, an indirect method using pressure signal to estimate the pulsatile flow was proposed. The mock circulatory system is first modeled with different Windkessel models. Then the aortic pressure and arterial pressure are considered as the input and observation variable, respectively, to estimate model pa- rameters and aortic flow based on the extended Kalman filter (EKF). The accuracy of flow estimation is e-valuated by the root mean square error index. The experimental results show that the four-element Wind-kessel model can describe the dynamic performance of the mock circulation system and thus estimate the aortic flow. This paper provides a novel method to measure the aortic flow in testing and evaluating cardio- vascular devices.%模拟循环系统主动脉内的流量波动很大,采用流量计直接测量受管道直径、管壁厚度、流量计量程等因素制约,不利于对不同研究对象进行模拟.文中提出一种利用压力信号间接测量主动脉流的方法.首先利用不同的Windkessel模型对模拟体循环系统进行建模,然后分别以主动脉压和动脉压作为输入变量和观测变量,利用扩展卡尔曼滤波器对模型参数和主动脉流进行联合估计.流量的估计精度采用均方根误差指标进行评估.结果表明,四元Windkessel模型可以很好地描述系统的动态性能并估计流量,为心血管装置的定量分析和测试提供了新的方法.

  10. The BIJOU Teaching Support System.

    Science.gov (United States)

    Wiseman, Michael

    1986-01-01

    Describes the large-class BIJOU teaching support system developed at University of California-Berkeley to facilitate recordkeeping and communication with support staff. Reasons why large classes exist, organizational elements, and teaching support systems requirements are reviewed. Tasks supported by the BIJOU saystem, costs, and possible…

  11. FY2000 report of the research results of medical/engineering cooperative research project, basic research on systems for minimally invasive diagnostic/treatment of circulatory system diseases, including prognostic diagnosis; 2000 nendo igaku kogaku renkeigata kenkyu jigyo, junkankikei shikkan ni taisuru yogo shindan wo fukumu teishinshu shindan chiryo system ni kansuru kiso kenkyu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    The basic researches on minimally invasive diagnostic/treatment systems are conducted for circulatory system diseases, and the FY 2000 results are reported. The program for developing the heart surgery supporting manipulator includes development of the manipulator of 7 degree of freedom and fail-safe mechanisms to be incorporated in the patient-side system, and research and development of the heart motion compensation type robot system. The program for developing the diagnosis/treatment system aided by intravascular optical analysis includes development of intravascular endoscopy by the aid of LED emitting blue color of high brightness, and automatic analyzer for the in vivo vascular endothelial cell functions. The program for the minimally invasive diagnostic system includes development of superimposing system for integrating the images by the NOGA system and cine-coronary angiography. The other R and D items include artificial vascular systems to be put in the blood vessels, adhesives for a living body, suture instruments for fine blood vessels, heart surgery supporting system, based on the infrared spectroscopy, endoscopic system for the cranical bones, arterialization method, and gene-aided treatment. (NEDO)

  12. Pediatric Circulatory System of Guardianship After Open-heart Surgery%小儿心内直视手术后循环系统的监护

    Institute of Scientific and Technical Information of China (English)

    董云芳

    2015-01-01

    Objective To study the analysis of pediatric open-heart surgery treatment of posterior circulation system monitoring measures. Methods Selected 64 cases in January 2014 to December 2014 in our hospital during open-heart surgery treatment,after surgery to give close monitoring to the circulatory system. Results In 64 cases,63 cases recovered and discharged,only 1 cases was death because of the low cardiac. Conclusion Pediatric heart surgery treatment,strict monitoring circulation system is the key to ensure the operation curative effect,help children better in disease and rehabilitation.%目的:研究分析小儿心内直视手术治疗后循环系统的监护措施。方法选择2014年1月~2014年12月期间在我院进行心内直视手术治疗的64例患儿,在术后对循环系统给予严密监护。结果本组64例患儿中,63例患儿痊愈出院,仅1例患儿因为低心排而死亡。结论小儿心脏手术治疗后,严格监护循环系统是确保手术疗效的关键,有助于患儿疾病的好转及康复。

  13. Bonghan circulatory system as an extension of acupuncture meridians%作为经络延伸的"Bonghan"循环系统(一)

    Institute of Scientific and Technical Information of China (English)

    Kwang-Sup Soh; 贾召锋; 张维波

    2010-01-01

    The Bonghan system is a newly-discovered circulatory system, which corresponds to classical acupuncture meridians and was discovered in the early 1960s by Bonghan Kim. Despite its potential importance in biology and medicine, it has been ignored or forgotten for a long time. Only recently have most of its significant parts, such as the Bonghan system (BHS) inside blood or lymph vessels, on the surfaces of internal organs, and in brain ventricles, been confirmed. For this, novel methods using modern technology were necessary because Bonghan Kim did not describe his methods. For example, Among other methods, the discovery of a BHS-specific dye, trypan blue, was one of the most important original contributions that made BHS observation possible. With this technique, the BHS in adipose tissue became traceable, and the BHS was discovered on the fascia surrounding tumor tissues, a finding which may have great significance in relation to serious health problems in modem society, namely, obesity and cancer.%BonIghan系统(BHS)是一个新发现的循环系统,与传统经络相吻合.BH系统在血管、淋巴管、器官表而与内部、脑室中的存在得到证实.为进一步证实该理论,本文融入现代技术的新方法,发现BH系统特异性染料锥虫蓝,可清楚观察到BH系统.采用此技术,可追踪脂肪组织中的BH系统,发现肿瘤筋膜上的BH系统,这对肥胖、癌症等问题的解决密切相关.

  14. Decision support systems

    DEFF Research Database (Denmark)

    Jørgensen, L N; Noe, E; Langvad, A M;

    2007-01-01

    system Crop Protection Online is widely used by advisors and as a learning tool for students. Although the system has been validated in many field trials over the years and has shown reliable results, the number of end-users among farmers has been relatively low during the last 10 years (approximately...... 1000 farmers). A sociological investigation of farmers' decision-making styles in the area of crop protection has shown that arable farmers can be divided into three major groups: (a) system-orientated farmers, (b) experience-based farmers and (c) advisory-orientated farmers. The information required...

  15. Reactor vessel support system. [LMFBR

    Science.gov (United States)

    Golden, M.P.; Holley, J.C.

    1980-05-09

    A reactor vessel support system includes a support ring at the reactor top supported through a box ring on a ledge of the reactor containment. The box ring includes an annular space in the center of its cross-section to reduce heat flow and is keyed to the support ledge to transmit seismic forces from the reactor vessel to the containment structure. A coolant channel is provided at the outside circumference of the support ring to supply coolant gas through the keyways to channels between the reactor vessel and support ledge into the containment space.

  16. Web-based support systems

    CERN Document Server

    Yao, JingTao

    2010-01-01

    The emerging interdisciplinary study of Web-based support systems focuses on the theories, technologies and tools for the design and implementation of Web-based systems that support various human activities. This book presents the state-of-the-art in Web-based support systems (WSS). The research on WSS is multidisciplinary and focuses on supporting various human activities in different domains/fields based on computer science, information technology, and Web technology. The main goal is to take the opportunities of the Web, to meet the challenges of the Web, to extend the human physical limita

  17. 2015 SCAI/ACC/HFSA/STS Clinical Expert Consensus Statement on the Use of Percutaneous Mechanical Circulatory Support Devices in Cardiovascular Care (Endorsed by the American Heart Association, the Cardiological Society of India, and Sociedad Latino Americana de Cardiologia Intervencion; Affirmation of Value by the Canadian Association of Interventional Cardiology-Association Canadienne de Cardiologie D'intervention).

    Science.gov (United States)

    Rihal, Charanjit S; Naidu, Srihari S; Givertz, Michael M; Szeto, Wilson Y; Burke, James A; Kapur, Navin K; Kern, Morton; Garratt, Kirk N; Goldstein, James A; Dimas, Vivian; Tu, Thomas

    2015-06-01

    Although historically the intra-aortic balloon pump has been the only mechanical circulatory support device available to clinicians, a number of new devices have become commercially available and have entered clinical practice. These include axial flow pumps, such as Impella®; left atrial to femoral artery bypass pumps, specifically the TandemHeart; and new devices for institution of extracorporeal membrane oxygenation. These devices differ significantly in their hemodynamic effects, insertion, monitoring, and clinical applicability. This document reviews the physiologic impact on the circulation of these devices and their use in specific clinical situations. These situations include patients undergoing high-risk percutaneous coronary intervention, those presenting with cardiogenic shock, and acute decompensated heart failure. Specialized uses for right-sided support and in pediatric populations are discussed and the clinical utility of mechanical circulatory support devices is reviewed, as are the American College of Cardiology/American Heart Association clinical practice guidelines.

  18. 2015 SCAI/ACC/HFSA/STS Clinical Expert Consensus Statement on the Use of Percutaneous Mechanical Circulatory Support Devices in Cardiovascular Care (Endorsed by the American Heart Association, the Cardiological Society of India, and Sociedad Latino Americana de Cardiologia Intervencion; Affirmation of Value by the Canadian Association of Interventional Cardiology-Association Canadienne de Cardiologie d'intervention).

    Science.gov (United States)

    Rihal, Charanjit S; Naidu, Srihari S; Givertz, Michael M; Szeto, Wilson Y; Burke, James A; Kapur, Navin K; Kern, Morton; Garratt, Kirk N; Goldstein, James A; Dimas, Vivian; Tu, Thomas

    2015-06-01

    Although historically the intra-aortic balloon pump has been the only mechanical circulatory support device available to clinicians, a number of new devices have become commercially available and have entered clinical practice. These include axial flow pumps, such as Impella(®); left atrial to femoral artery bypass pumps, specifically the TandemHeart; and new devices for institution of extracorporeal membrane oxygenation. These devices differ significantly in their hemodynamic effects, insertion, monitoring, and clinical applicability. This document reviews the physiologic impact on the circulation of these devices and their use in specific clinical situations. These situations include patients undergoing high-risk percutaneous coronary intervention, those presenting with cardiogenic shock, and acute decompensated heart failure. Specialized uses for right-sided support and in pediatric populations are discussed and the clinical utility of mechanical circulatory support devices is reviewed, as are the American College of Cardiology/American Heart Association clinical practice guidelines.

  19. 2015 SCAI/ACC/HFSA/STS Clinical Expert Consensus Statement on the Use of Percutaneous Mechanical Circulatory Support Devices in Cardiovascular Care: Endorsed by the American Heart Assocation, the Cardiological Society of India, and Sociedad Latino Americana de Cardiologia Intervencion; Affirmation of Value by the Canadian Association of Interventional Cardiology-Association Canadienne de Cardiologie d'intervention.

    Science.gov (United States)

    Rihal, Charanjit S; Naidu, Srihari S; Givertz, Michael M; Szeto, Wilson Y; Burke, James A; Kapur, Navin K; Kern, Morton; Garratt, Kirk N; Goldstein, James A; Dimas, Vivian; Tu, Thomas

    2015-05-19

    Although historically the intra-aortic balloon pump has been the only mechanical circulatory support device available to clinicians, a number of new devices have become commercially available and have entered clinical practice. These include axial flow pumps, such as Impella(®); left atrial to femoral artery bypass pumps, specifically the TandemHeart; and new devices for institution of extracorporeal membrane oxygenation. These devices differ significantly in their hemodynamic effects, insertion, monitoring, and clinical applicability. This document reviews the physiologic impact on the circulation of these devices and their use in specific clinical situations. These situations include patients undergoing high-risk percutaneous coronary intervention, those presenting with cardiogenic shock, and acute decompensated heart failure. Specialized uses for right-sided support and in pediatric populations are discussed and the clinical utility of mechanical circulatory support devices is reviewed, as are the American College of Cardiology/American Heart Association clinical practice guidelines.

  20. 2015 SCAI/ACC/HFSA/STS Clinical Expert Consensus Statement on the Use of Percutaneous Mechanical Circulatory Support Devices in Cardiovascular Care (Endorsed by the American Heart Association, the Cardiological Society of India, and Sociedad Latino Americana de Cardiología Intervencionista; Affirmation of Value by the Canadian Association of Interventional Cardiology-Association Canadienne de Cardiologie d'intervention).

    Science.gov (United States)

    Rihal, Charanjit S; Naidu, Srihari S; Givertz, Michael M; Szeto, Wilson Y; Burke, James A; Kapur, Navin K; Kern, Morton; Garratt, Kirk N; Goldstein, James A; Dimas, Vivian; Tu, Thomas

    2015-06-01

    This article provides a brief summary of the relevant recommendations and references related to percutaneous mechanical circulatory support. The goal was to provide the clinician with concise, evidence-based contemporary recommendations, and the supporting documentation to encourage their application. The full text includes disclosure of all relevant relationships with industry for each writing committee member. A fundamental aspect of all expert consensus statements is that these carefully developed, evidence-based documents can neither encompass all clinical circumstances, nor replace the judgment of individual physicians in management of each patient. The science of medicine is rooted in evidence, and the art of medicine is based on the application of this evidence to the individual patient. This expert consensus statement has adhered to these principles for optimal management of patients requiring percutaneous mechanical circulatory support.

  1. Transcatheter aortic valve implantation in a patient with circulatory collapse, using the lucas® chest compression system

    DEFF Research Database (Denmark)

    Jensen, Peter Blom; Andersen, Claus; Nissen, Henrik

    2013-01-01

    We describe a case of Transcatheter Aortic Valve Implantation (TAVI) using the LUCAS® Chest Compression System in an elderly high risk patient with severe aortic stenosis and heart failure. In this case, the patient developed severe aortic regurgitation following predilatation of the native aortic...... or cardiac damage. This case report shows, that it is possible to perform the TAVI procedure under ongoing A-CPR and that A-CPR, judged by invasive blood pressures, was capable of maintaining a satisfactory perfusion pressure even with a damaged aortic valve. © 2012 Wiley Periodicals, Inc....... valve and automated cardiopulmonary resuscitation (A-CPR) was initiated. The procedure was performed under ongoing A-CPR for a total of 28 min. The patient was transferred to the intensive care unit and to a step down unit the following day. At follow-up 30 days later, she showed no signs of neurologic...

  2. Circulatory death determination in uncontrolled organ donors: a panel viewpoint.

    Science.gov (United States)

    Bernat, James L; Bleck, Thomas P; Blosser, Sandralee A; Bratton, Susan L; Capron, Alexander M; Cornell, Danielle; DeVita, Michael A; Fulda, Gerard J; Glazier, Alexandra K; Gries, Cynthia J; Mathur, Mudit; Nakagawa, Thomas A; Shemie, Sam D

    2014-04-01

    One barrier for implementing programs of uncontrolled organ donation after the circulatory determination of death is the lack of consensus on the precise moment of death. Our panel was convened to study this question after we performed a similar analysis on the moment of death in controlled organ donation after the circulatory determination of death. We concluded that death could be determined by showing the permanent or irreversible cessation of circulation and respiration. Circulatory irreversibility may be presumed when optimal cardiopulmonary resuscitation efforts have failed to restore circulation and at least a 7-minute period has elapsed thereafter during which autoresuscitation to restored circulation could occur. We advise against the use of postmortem organ support technologies that reestablish circulation of warm oxygenated blood because of their risk of retroactively invalidating the required conditions on which death was declared.

  3. Magnetic Resonance Microscopy of Flows and Compressions of the Circulatory, Respiratory, and Digestive Systems in Pupae of the Tobacco Hornworm, Manduca sexta

    OpenAIRE

    2008-01-01

    Circulatory, respiratory, and digestive motions in Manduca sexta pupae were observed using proton-density weighted and fast-imaging with steady-state free procession magnetic resonance microscopy. Proton-density weighted images clearly differentiated pupal air sacs from the hemolymph and organs because, as expected, the air sacs appeared dark in these images. Steady-state free procession imaging allowed real-time monitoring of respiration and circulation, creating movies of hemolymph circulat...

  4. Clinical Information Support System (CISS)

    Data.gov (United States)

    Department of Veterans Affairs — Clinical Information Support System (CISS) is a web-based portal application that provides a framework of services for the VA enterprise and supplies an integration...

  5. Structures with Reconfigurable Circulatory Systems

    Science.gov (United States)

    2008-05-16

    precedent for the general concept and aims, it was naturally disappointing not to be the first to report this chemistry. In parallel with the...polymerization in reverse. Thiol compounds, such as glutathione, cysteine and homocysteine are a natural reservoir of reductive capacities of the cells...Cysteine, an amino acid, is a critical substrate in biosynthesis of proteins, glutathione, taurine sulfate and the exceptionally metabolically active

  6. Rhode Island Model Evaluation & Support System: Support Professional. Edition II

    Science.gov (United States)

    Rhode Island Department of Education, 2015

    2015-01-01

    Rhode Island educators believe that implementing a fair, accurate, and meaningful evaluation and support system for support professionals will help improve student outcomes. The primary purpose of the Rhode Island Model Support Professional Evaluation and Support System (Rhode Island Model) is to help all support professionals do their best work…

  7. Optimization of vaporization flue circulatory system for converter in Anyang Iron and Steel Group Co., Ltd%安钢转炉汽化烟道循环系统优化

    Institute of Scientific and Technical Information of China (English)

    罗大春; 周友军; 李军强; 马正锋

    2012-01-01

    The vaporization flue circulatory systems were reformed to solve the leakage problems of the fixed chimney cap and the tail flue of the 150 t converter in Anyang Iron & Steel Group Co. , Ltd. An extra pump was added into the old high - pressure pump system to enhance the circulatory cooling water flow, and the natural circulation system of the tail flue was changed for the forced high-pressure circulation system and combined with the forced circulation system of the fixed chimney cap. This optimization measure extended the service life of the fixed chimney cap for more than six months, and decreased the water leakage of tail flue by almost 80%.%针对安钢150 t转炉汽化烟道循环系统固定烟罩、尾部烟道频繁漏水问题,安钢对转炉汽化烟道循环系统进行改造.将原系统设计的l用1备高压泵改为2用1备增加循环冷却水量,并将尾部烟道高压自然循环改为强制循环并入固定烟罩强制循环系统,延长固定烟罩使用寿命6个月以上,减少尾部烟道漏水80%以上.

  8. 堆浸浸出工艺循环系统改造实效性研究%Study on actual effect of circulatory system rebuilding of accumulation-dipping technology

    Institute of Scientific and Technical Information of China (English)

    王公洲; 高灶其

    2015-01-01

    堆浸是黄金矿山处理低品位氧化矿石的最佳手段之一,喷淋液体的循环系统是该手段的重要组成部分,它需要场地和落差,找到场地和落差两者都具备的条件非常困难。本文采用实例对液体通过吸附塔流程工艺的改造进行了探讨,即:改落差循环工艺为机械循环工艺。这一工艺的改造,解决了深山区对地理环境的制约因素,简化了管理的程序,增大了系统的安全性,给矿山企业带来了很大的经济效益和社会效益。%Accumulation‐dipping is one of the best ways to deal with oxidative ore in low grade in gold mining area ,circulatory system of spray liquid is a important part of the technology ,it needs space and fall . It is easy to find fall ,hard to find sapce and harder to find ground which possess two features in mountainous district .We executed a series of tasks to solve this problem ,this paper discussed the technology transformation that liquid flow through the adsorption tower ,changing from fall circulatory technology to mechanism circulatory technology .Rebuilding of the technology solved confining elements of geographical conditions in remote mountains ,simplified management procedure ,strengthened safety of system ,brought much economical benefit and social benefit to mining corporation .

  9. [Remote radiation planning support system].

    Science.gov (United States)

    Atsumi, Kazushige; Nakamura, Katsumasa; Yoshidome, Satoshi; Shioyama, Yoshiyuki; Sasaki, Tomonari; Ohga, Saiji; Yoshitake, Tadamasa; Shinoto, Makoto; Asai, Kaori; Sakamoto, Katsumi; Hirakawa, Masakazu; Honda, Hiroshi

    2012-08-01

    We constructed a remote radiation planning support system between Kyushu University Hospital (KUH) in Fukuoka and Kyushu University Beppu Hospital (KBH) in Oita. Between two institutions, radiology information system for radiotherapy division (RT-RIS) and radiation planning system (RTPS) were connected by virtual private network (VPN). This system enables the radiation oncologists at KUH to perform radiotherapy planning for the patients at KBH. The detail of the remote radiation planning support system in our institutions is as follows: The radiation oncologist at KBH performs radiotherapy planning and the data of the patients are sent anonymously to the radiation oncologists at KUH. The radiation oncologists at KUH receive the patient's data, access to RTPS at KBH, verify or change the radiation planning at KBH: Radiation therapy is performed at KBH according to the confirmed plan by the radiation oncologists at KUH. Our remote radiation planning system is useful for providing radiation therapy with safety and accuracy.

  10. User's instructions for the Guyton circulatory dynamics model using the Univac 1110 batch and demand processing (with graphic capabilities)

    Science.gov (United States)

    Archer, G. T.

    1974-01-01

    The model presents a systems analysis of a human circulatory regulation based almost entirely on experimental data and cumulative present knowledge of the many facets of the circulatory system. The model itself consists of eighteen different major systems that enter into circulatory control. These systems are grouped into sixteen distinct subprograms that are melded together to form the total model. The model develops circulatory and fluid regulation in a simultaneous manner. Thus, the effects of hormonal and autonomic control, electrolyte regulation, and excretory dynamics are all important and are all included in the model.

  11. ELECTRICAL SUPPORT SYSTEM DESCRIPTION DOCUMENT

    Energy Technology Data Exchange (ETDEWEB)

    S. Roy

    2004-06-24

    The purpose of this revision of the System Design Description (SDD) is to establish requirements that drive the design of the electrical support system and their bases to allow the design effort to proceed to License Application. This SDD is a living document that will be revised at strategic points as the design matures over time. This SDD identifies the requirements and describes the system design as they exist at this time, with emphasis on those attributes of the design provided to meet the requirements. This SDD has been developed to be an engineering tool for design control. Accordingly, the primary audience/users are design engineers. This type of SDD both ''leads'' and ''trails'' the design process. It leads the design process with regard to the flow down of upper tier requirements onto the system. Knowledge of these requirements is essential in performing the design process. The SDD trails the design with regard to the description of the system. The description provided in the SDD is a reflection of the results of the design process to date. Functional and operational requirements applicable to electrical support systems are obtained from the ''Project Functional and Operational Requirements'' (F&OR) (Siddoway 2003). Other requirements to support the design process have been taken from higher-level requirements documents such as the ''Project Design Criteria Document'' (PDC) (Doraswamy 2004), and fire hazards analyses. The above-mentioned low-level documents address ''Project Requirements Document'' (PRD) (Canon and Leitner 2003) requirements. This SDD contains several appendices that include supporting information. Appendix B lists key system charts, diagrams, drawings, and lists, and Appendix C includes a list of system procedures.

  12. Decision Support Systems in Logistics

    Science.gov (United States)

    Encheva, Sylvia; Kondratenko, Yuriy; Solesvik, Maryna Z.; Tumin, Sharil

    2008-11-01

    Experience shows that intuitive judgment and decision making is not allwas of sufficient quality and is getting worse in the presence of increasing complexity. One of the solutions to such problems is to use decision support systems. This paper focuses on assessment criteria of delivery quality in the transport logistics.

  13. Photobioreactors in Life Support Systems.

    Science.gov (United States)

    Wagner, Ines; Braun, Markus; Slenzka, Klaus; Posten, Clemens

    2016-01-01

    Life support systems for long-term space missions or extraterrestrial installations have to fulfill major functions such as purification of water and regeneration of atmosphere as well as the generation of food and energy. For almost 60 years ideas for biological life support systems have been collected and various concepts have been developed and tested. Microalgae as photosynthetic organisms have played a major role in most of these concepts. This review deals with the potentials of using eukaryotic microalgae for life support systems and highlights special requirements and frame conditions for designing space photobioreactors especially regarding illumination and aeration. Mono- and dichromatic illumination based on LEDs is a promising alternative for conventional systems and preliminary results yielded higher photoconversion efficiencies (PCE) for dichromatic red/blue illumination than white illumination. Aeration for microgravity conditions should be realized in a bubble-free manner, for example, via membranes. Finally, a novel photobioreactor concept for space application is introduced being parameterized and tested with the microalga Chlamydomonas reinhardtii. This system has already been tested during two parabolic flight campaigns.

  14. Modeling Advance Life Support Systems

    Science.gov (United States)

    Pitts, Marvin; Sager, John; Loader, Coleen; Drysdale, Alan

    1996-01-01

    Activities this summer consisted of two projects that involved computer simulation of bioregenerative life support systems for space habitats. Students in the Space Life Science Training Program (SLSTP) used the simulation, space station, to learn about relationships between humans, fish, plants, and microorganisms in a closed environment. One student complete a six week project to modify the simulation by converting the microbes from anaerobic to aerobic, and then balancing the simulation's life support system. A detailed computer simulation of a closed lunar station using bioregenerative life support was attempted, but there was not enough known about system restraints and constants in plant growth, bioreactor design for space habitats and food preparation to develop an integrated model with any confidence. Instead of a completed detailed model with broad assumptions concerning the unknown system parameters, a framework for an integrated model was outlined and work begun on plant and bioreactor simulations. The NASA sponsors and the summer Fell were satisfied with the progress made during the 10 weeks, and we have planned future cooperative work.

  15. Relationship of spontaneous retinal vein pulsation with ocular circulatory cycle.

    Directory of Open Access Journals (Sweden)

    Mijin Kim

    Full Text Available PURPOSE: To determine the timing of spontaneous venous pulsation (SVP relative to the ocular circulatory cycle by using the movie tool of confocal scanning laser ophthalmoloscope. METHODS: A video recording of the fundus was obtained using a confocal scanning laser ophthalmoscope (Spectralis HRA, Heidelberg Engineering, Heidelberg, Germany at 8 frames/s in 47 eyes (15 glaucoma patients and 32 glaucoma suspects with visible pulsation of both the central retinal artery (CRA and vein (CRV. The timing of the maximum and minimum diameters of the CRA (CRA(max and CRAmin, respectively and CRV (CRV(max and CRV(min, respectively was identified during four pulse cycles. The interval between CRV(min and CRA(min, and between CRV(max and CRA(max was expressed as the number of frames and as a percentage of the ocular circulatory cycle. RESULTS: The ocular circulatory cycle (from one CRA(max to the next lasted 7.7 ± 1.0 frames (958.8 ± 127.2 ms, mean ± SD, with a mean pulse rate of 62.6 beats/min. The diameter of the CRA was increased for 2.4 ± 0.5 frames (301.9 ± 58.8 ms and decreased for 5.3 ± 0.9 frames (656.9 ± 113.5 ms. CRV(max occurred 1.0 ± 0.2 frames after CRA(max (equivalent to 13.0% of the ocular circulatory cycle, while CRV(min occurred 1.1 ± 0.4 frames after CRA(min (equivalent to 14.6% of the ocular circulatory cycle. CONCLUSIONS: During SVP, the diameter of the CRV began to decrease at early diastole, and the reduction persisted until early systole. This finding supports that CRV collapse occurs during ocular diastole.

  16. A System Supporting Qualitative Research

    Directory of Open Access Journals (Sweden)

    Emilia Todorova

    2014-11-01

    Full Text Available this paper presents a system aimed to be entirely located in the Internet. The database, server side, logic and user interface are accessible regardless the location and equipment of the working team members. The system supports qualitative analysis of large datasets, and the work can be distributed among several team members or teams. A modified mixed method for developing software projects is used, according to the peculiarities of our case, splitting the phase of code writing into two sub-phases each with different number of iterations.

  17. [Oral contraception and circulatory risks].

    Science.gov (United States)

    Wingrave, S J

    1984-10-01

    The longterm prospective study of health effects of oral contraceptives (OCs) conducted by the Royal College of General Practitioners compared 23,000 OC users with 23,000 controls matched for age and marital status. As of 1981, 55 deaths attributable to circulatory problems had occurred in ever-users of OCs, ciompared to 10 in controls, giving a relative risk of 4.2 for OC users. No relation was found between duration of use and mortality risk among users, although mortality risks were greater at all durations of use than for nonusers. Parity was related to mortality risk among users but not among controls. The most significant factors affecting the relation between pill use and circulatory risk were age and smoking. Among users who smoked, the risk ratios were 3.4 for those aged 25-34, 4.2 for those aged 35-44, 7.4 for those aged 45 and over, and 5.1 for the entire group. Among nonsmoking pill users, the ratios were 1.6 for those aged 25-34, 3.3 for those aged 35-44, 4.6 for those 45 and over, and 3.2 for the total sample. Among smokers, the rates of excess deaths were 1 in 10,000 for users aged 15-34, 1 in 2000 for those aged 35-44, and 1 in550 for those aged 45 and over. Among nonsmokers, the rates were 1 in 50,000 users for those aged 25-34, 1 in 6700 for those aged 35-44, and 1 in 2500 for those aged 45 and over. The majority of deaths were attributed to ischemic cardiac problems and to sub-arachnoid hemorrhages, and risks appeared to be elevated in former as well as current users. The total incidence of circulatory effects in former users appears to be elevated only for cerebrovascular disorders, but the suggestion of residual effects requires further study before conclusions can be drawn. Smokers who developed cardiovascular or cerebrovascular problems were at 2-3 times greater risk of dying than were other women. The percentages of fatal cases of ischemic heart and cerebrovascular diseases were 22.8% among ever-users who smoked, 10.9% among controls who

  18. Effect of permissive hypercapnia on respiratory circulatory system%允许性高碳酸血症对呼吸循环系统的影响

    Institute of Scientific and Technical Information of China (English)

    杨田军; 刘宝

    2011-01-01

    允许性高碳酸血症是肺保护性通气策略的被动结果.早期认为动脉血二氧化碳分压升高及由之引起的酸中毒会导致心血管恶性事件发生率增高.而近期的研究结果显示高碳酸血症本身对脏器有保护作用,从而引入了治疗性高碳酸血症的概念.高碳酸血症可显著影响呼吸循环功能.该文从高碳酸血症对血管张力、肺泡通透性的影响等几个方面作一综述.%Permissive hypercapnia is a passive result of lung protective ventilation strategy. Earlier studies thought that increased arterial carbon dioxide pressure and acidosis caused by it could lead to increased incidence of cardiovascular vicious events. But recent studies have shown that hypercapnia has a protective effect on organs,thereby the concept of therapeutic hypercapnia is introduced. Hypercapnia can significantly affect respiratory circulatory functions. This article reviews the effects of hypercapnia on vascular tone,alveolar permeability.

  19. Effect of Kampo formulations (traditional Chinese medicine) on circulatory parameters.

    Science.gov (United States)

    Xu, F H; Uebaba, K

    1999-01-01

    The pharmacological action of 6 main Kampo formulations (1.Mao -to: [Japanese pictograph see text] MA HUANG TANG; 2. Shimbu -to: [Japanese pictograph see text]: ZHEN WU TANG; 3. Ninjin -to: [Japanese pictograph see text] : REN SHEN TANG; 4.Shigyaku-san: [Japanese pictograph see text] : SI NI SAN; 5.Keishi-to: Japanese pictograph see text] : GUI ZHI TANG; 6. Shimotsu - to: [Japanese pictograph see text] : SI WU TANG) on circulatory and autonomic nervous system were studied. 7 healthy adult males( age, 22.3 +/- 1.8 years old ) had 6 basic Kampo formulations, followed by noninvasive measurement of systolic blood pressure (SBP), mean blood pressure (MBP), diastolic blood pressure (DBP), heart rate (HR), stroke volume (SV), cardiac output (CO ), cardiacindex (CI), total peripheral resistance (TPR) by means of systolic area method of brachialsphygmography, every 30 minutes for 2 hours. As results, Mao - to induced an increase of BP,HR,SV,CO and CI, but a decrease of TPR. Keishi - to induced an increase of SBP and SV, and Shimotsu-to induced an increase of DBP and MBP, HR was slowed during former period after oral administration of Shigyaku - san, and later period after oral administration of Shimbu-to and Shimotsu-to. Regarding autonomic activity, Mao-to(former period of experiment ), Shimbu - to and Shimotsu-to induced supression of sympathetic activity, on the other hand, Mao-to (later period of experiment ) and Shiyaku - san showed a tendency of parasympathomimetic action. Mao -to induced the strongest activation of circulatory system of 6 main farmulations, and showed change of autonomic nervous activity, however, the change of circulatory and automonic nervous activity were not coincident each other. It was speculated that comprehensive mechanism of Mao-to were not only dependent of ephedrin, main active constituent of Mao, but also dependent on Keishi's vasodilatory action in it. Ninjin -to showed no actions on circulatory or autonomic system. This is indicated

  20. Feasibility of a TinyPump system for pediatric CPB, ECMO, and circulatory assistance: hydrodynamic performances of the modified pump housing for implantable TinyPump.

    Science.gov (United States)

    Yokoyama, Naoyuki; Suzuki, Masaaki; Hoshi, Hideo; Ohuchi, Katsuhiro; Fujimoto, Tetsuo; Takatani, Setsuo

    2007-01-01

    The TinyPump is a miniature centrifugal blood pump with an extremely small priming volume of 5 ml, allowing blood transfusion free cardiopulmonary bypass as well as extracorporeal membrane oxygenation in pediatric patients. In this study, a new pump housing with the angled inlet port (25 degrees toward impeller center with respect to the flow axis) was designed to optimize the pump displaced volume and to extend the application of the TinyPump to implantable support The fluid dynamic performance analysis revealed that the head pressure losses increased from 3 to 17 mm Hg in comparison with straight port design as the pump rotational speed increased from 2,000 to 4,000 rpm. This was probably caused by perturbed flow patterns at the site of the inlet bent port area and streamline hitting the off-center of the impeller. No significant effect on pumping efficiency was observed because of modification in inlet port design. Modification in the inflow and outflow port designs together with the drive mechanism reduces the height of the pump system, including the motor, to 27 mm yielding the displaced volume of 68 ml in comparison with 40 mm of the paracorporeal system with the displaced volume of 105 ml. Further analysis in terms of hemolytic as well as antithrombogenic performance will be carried out to finalize the housing design for the implantable version of the TinyPump.

  1. Adaptive Collaboration Support Systems: Designing Collaboration Support for Dynamic Environments

    NARCIS (Netherlands)

    Janeiro, J.; Knoll, S.W.; Lukosch, S.G.; Kolfschoten, G.L.

    2012-01-01

    Today, engineering systems offer a variety of local and webbased applications to support collaboration by assisting groups in structuring activities, generating and sharing data, and improving group communication. To ensure the quality of collaboration, engineering system design needs to analyze and

  2. Professional Growth & Support System Self-Assessment

    Science.gov (United States)

    Education Resource Strategies, 2013

    2013-01-01

    The "Professional Growth & Support System Self-Assessment" is designed to help school systems evaluate their current Professional Growth & Support strategy. The self-assessment is organized around the "Eight Principles of Strategic Professional Growth & Support." Each section allows school leaders to identify the…

  3. Clinical Investigation of Hyperthermia Perfusion Extracorporeal Circulatory System in Treatment of Malignant Pleural Effusion%恒温体外循环热灌注治疗恶性胸腔积液的临床观察

    Institute of Scientific and Technical Information of China (English)

    解国清; 廖国清; 李雷; 马太林; 毛利伟

    2011-01-01

    目的:观察恒温体外循环热灌注化疗治疗恶性胸腔积液的临床疗效.方法:于2008 年1月~2011 年4月选择经病理证实的肺癌或恶性间皮瘤同时伴发恶性胸腔积液的患者86 例,随机分为治疗组(n=44) 和对照组(n=42).治疗组用Astronaut 体外循环热疗机热灌注化疗,对照组仅行普通腔内热灌注化疗.两组化疗药物为顺铂,首次剂量90mg,以后每次60mg,1 次/周,共6周.治疗前后测定胸水量,并观察生活质量改善情况及治疗副反应.结果:治疗6周后,治疗组胸腔积液CR18 例,PR20 例,总有效率86.4%,对照组CR11 例,PR17 例,总有效率66.7%,差异有统计学上显著意义(P<0.05).治疗组生活质量改善亦优于对照组(P<0.05).两组患者均出现了轻微的消化道反应,可耐受.结论:体外循环热灌注顺铂治疗恶性胸腔积液,疗效显著.%Objective: To investigate clinical efficacy of hyperthermia perfusion extracorporeal circulatory system in treatment of malignant pleural effusion. Methods: Eighty-six malignant mesothelioma and lung cancer patients with malignant pleural effusion diagnosed by pathological evidences were divided into treatment group(n=44) and control group(n=42) randomly in Jan. 2008 to April 2011. The treatment group was dealt with hyperthermia perfusion extracorporeal circulatory system with DDP injection, while the control group received hyperthermia perfusion and DDP intracavity injection only. The same dose of DDP were injected in two groups, firstly 90mg, and the 60mg each time, once a week, and six times in total. The volume of effusion were measured at the baseline and after treatment. Life quality and side-effects were observed in two groups too. Results: There were 18 complete response (CR) and 20 partial response(PR) in treatment group, the total effective rate was 86.4% , while 11 CR and 17 PR in control group(66.7%). Life quality improved significantly in treatment group compared with control group, while two

  4. [Circulatory failure in chronic glomerulo- and pyelonephritis].

    Science.gov (United States)

    Kulakov, G P; Melikian, A M; Seĭsembekov, T Z

    1982-01-01

    The frequency and degree of circulatory insufficiency depending on the stage of the disease are analyzed in 404 patients with chronic glomerulonephritis and 145 patients with chronic pyelonephritis aged 15 to 74 years. When the renal function is still preserved different degrees of circulatory insufficiency are diagnosed in 29.4% of patients. Circulatory insufficiency complicates more often chronic glomerulonephritis than pyelonephritis and is more common in the aged. Latent cardiac insufficiency is more common. In the period of chronic renal insufficiency cardiac decompensation is seen in 78.1% of cases, its frequency is practically the same in glomerulonephritis and pyelonephritis. The mechanisms of development of cardiac insufficiency and the principles of treatment depending on the functional state of the kidneys are discussed.

  5. Developing Information Systems for Competitive Intelligence Support.

    Science.gov (United States)

    Hohhof, Bonnie

    1994-01-01

    Discusses issues connected with developing information systems for competitive intelligence support; defines the elements of an effective competitive information system; and summarizes issues affecting system design and implementation. Highlights include intelligence information; information needs; information sources; decision making; and…

  6. Support Systems for Treatment Integrity

    Science.gov (United States)

    Goense, Pauline Brigitta; Boendermaker, Leonieke; van Yperen, Tom

    2016-01-01

    Objective: This systematic review evaluates the content of effective support provided to practitioners of evidence-based interventions in order to establish and maintain treatment integrity. Method: Four articles covering six outcome studies are included in this review, these studies (1) adequately operationalized treatment integrity procedures…

  7. Support Systems for Treatment Integrity

    NARCIS (Netherlands)

    Goense, Pauline Brigitta; Boendermaker, Leonieke; van Yperen, Tom

    2016-01-01

    Objective: This systematic review evaluates the content of effective support provided to practitioners of evidence-based interventions in order to establish and maintain treatment integrity. Method: Four articles covering six outcome studies are included in this review, these studies (1) adequately

  8. Examining teachers' perceptions of children's support systems.

    Science.gov (United States)

    Parish, T S

    1990-01-01

    Teachers of 94 youth evaluated the functionality of their students' support systems by completing the Personal History Inventory for Children (Parish & Wigle, 1985). An analysis of variance revealed significant main effects due to students' family structure, gender, and birth order. Specifically, youth from divorced nonremarried and divorced remarried families experienced more dysfunctional support systems than youth from intact families. Further, boys were found to be at more risk than girls, and later borns were found to experience more support system failure than firstborns.

  9. Supporting Multiple Cognitive Processing Styles Using Tailored Support Systems

    Energy Technology Data Exchange (ETDEWEB)

    Tuan Q. Tran; Karen M. Feigh; Amy R. Pritchett

    2007-08-01

    According to theories of cognitive processing style or cognitive control mode, human performance is more effective when an individual’s cognitive state (e.g., intuition/scramble vs. deliberate/strategic) matches his/her ecological constraints or context (e.g., utilize intuition to strive for a "good-enough" response instead of deliberating for the "best" response under high time pressure). Ill-mapping between cognitive state and ecological constraints are believed to lead to degraded task performance. Consequently, incorporating support systems which are designed to specifically address multiple cognitive and functional states e.g., high workload, stress, boredom, and initiate appropriate mitigation strategies (e.g., reduce information load) is essential to reduce plant risk. Utilizing the concept of Cognitive Control Models, this paper will discuss the importance of tailoring support systems to match an operator's cognitive state, and will further discuss the importance of these ecological constraints in selecting and implementing mitigation strategies for safe and effective system performance. An example from the nuclear power plant industry illustrating how a support system might be tailored to support different cognitive states is included.

  10. Controlled Ecological Life Support System. Life Support Systems in Space Travel

    Science.gov (United States)

    Macelroy, R. D. (Editor); Smernoff, D. T. (Editor); Klein, H. P. (Editor)

    1985-01-01

    Life support systems in space travel, in closed ecological systems were studied. Topics discussed include: (1) problems of life support and the fundamental concepts of bioregeneration; (2) technology associated with physical/chemical regenerative life support; (3) projection of the break even points for various life support techniques; (4) problems of controlling a bioregenerative life support system; (5) data on the operation of an experimental algal/mouse life support system; (6) industrial concepts of bioregenerative life support; and (7) Japanese concepts of bioregenerative life support and associated biological experiments to be conducted in the space station.

  11. PPL Travel & Mission Support System

    Data.gov (United States)

    US Agency for International Development — PTRAMS is a travel data collection system for PPL that collects information on both the basic details of an employee's trips (destination, length, purpose, etc.) and...

  12. DCHA Travel & Mission Support System

    Data.gov (United States)

    US Agency for International Development — DTRAMS is a travel data collection system for DCHA that collects information on both the basic details of an employee's trips (destination, length, purpose, etc.)...

  13. GH Travel & Mission Support System

    Data.gov (United States)

    US Agency for International Development — HTRAMS is a travel data collection system for GH that collects information on both the basic details of an employee's trips (destination, length, purpose, etc.) and...

  14. Circulatory abnormalities in cirrhosis with focus on neurohumoral aspects

    DEFF Research Database (Denmark)

    Møller, S; Henriksen, Jens Henrik Sahl

    1997-01-01

    -angiotensin-aldosterone system, and elevated circulating vasopressin, endothelin-1 may also be implicated in the hemodynamic counter-regulation in cirrhosis. Recent research has focused on the assertion that the hemodynamic and neurohumoral abnormalities in cirrhosis are part of a general circulatory dysfunction influencing...... resistance are decreased. A peripheral arterial vasodilatation may be of pathogenic importance to the low systemic vascular resistance as it directly correlates to the degree of central hypovolemia. It may therefore be an important element in the development of the low arterial blood pressure...

  15. Decision Support and Knowledge-Based Systems.

    Science.gov (United States)

    Konsynski, Benn R.; And Others

    1988-01-01

    A series of articles addresses issues concerning decision support and knowledge based systems. Topics covered include knowledge-based systems for information centers; object oriented systems; strategic information systems case studies; user perception; manipulation of certainty factors by individuals and expert systems; spreadsheet program use;…

  16. Developing Sustainable Life Support System Concepts

    Science.gov (United States)

    Thomas, Evan A.

    2010-01-01

    Sustainable spacecraft life support concepts may allow the development of more reliable technologies for long duration space missions. Currently, life support technologies at different levels of development are not well evaluated against each other, and evaluation methods do not account for long term reliability and sustainability of the hardware. This paper presents point-of-departure sustainability evaluation criteria for life support systems, that may allow more robust technology development, testing and comparison. An example sustainable water recovery system concept is presented.

  17. Anastomose cavo-pulmonar associada ao suporte circulatório esquerdo comparada à assistência biventricular na falência cardíaca aguda Cavo-pulmonary anastomosis associated with left ventricular in comparison with biventricular circulatory support in acute heart failure

    Directory of Open Access Journals (Sweden)

    Luis Alberto Saraiva Santos

    2012-12-01

    Full Text Available OBJETIVO: Este estudo avaliou o desempenho hemodinâmico e as alterações miocárdicas decorrentes do emprego de dispositivos de assistência ventricular esquerda (DAVE, associado ou não à descompressão do ventrículo direito por meio de derivação cavo-pulmonar, sendo esses achados comparados ao emprego de assistência circulatória biventricular. MÉTODOS: Vinte e um suínos foram submetidos à indução de insuficiência cardíaca através de fibrilação ventricular, sendo a atividade circulatória mantida por DAVE durante 180 minutos. No grupo controle, foi apenas implantado o DAVE. No grupo derivação, além do DAVE foi realizada cirurgia de derivação cavo-pulmonar. No grupo biventricular, foi instituída assistência biventricular. Foram monitoradas as pressões intracavitárias por 3 horas de assistência e amostras do endocárdio dos dois ventrículos foram coletadas e analisadas à microscopia óptica e eletrônica. RESULTADOS: O lactato sérico foi significativamente menor no grupo biventricular (P=0,014. A diferença observada entre o fluxo do DAVE nos grupos derivação e controle (+55±14 ml/kg/min, P=0,072 não foi significativa, enquanto que o fluxo no grupo biventricular foi significativamente maior (+93±17 ml/kg/min, P=0,012 e se manteve estável durante o experimento. A pressão arterial média (PAM se manteve constante apenas no grupo biventricular (POBJECTIVE: Right ventricular (RV failure during left ventricular assist device (LVAD support can result in severe hemodynamic compromise with high mortality. This study investigated the acute effects of cavo-pulmonary anastomosis on LVAD performance and RV myocardial compromise in comparison with biventricular circulatory support, in a model of biventricular failure. METHODS: LVAD support was performed by centrifugal pump in 21 pigs with severe biventricular failure obtained by FV induction. Animals were randomized to be submitted to cavo-pulmonary anastomosis, to

  18. On the Instability of Equilibrium of Nonholonomic Systems With Dissipation and Circulatory Forces%非完整系统有耗散和循环力时的平衡不稳定性

    Institute of Scientific and Technical Information of China (English)

    M·韦仕科尉克; V·科尉克; A·奥布拉德尉克

    2011-01-01

    The equilibrium instability problem of the scleronomic nonholonomic systems acted upon by dissipative, conservative, circulatory forces was discussed. The applied methodology was based on the existence of solutions of differential equations of motion which asymptotically tend to the equilibrium state of the system, as t →- ∞. It was assumed that the kinetic energy,the Rayleigh dissipation function, the positional forces in the neighborhood of the equilibrium position are infinitely differentiable functions. The results obtained, which partially generalize results from [ V V Kozlov. On the asymptotic motions of systems with dissipation. Prikl Math Mekh, 1994, 58 (4): 31-36. (in Russian); D R Merkin. Introduction to the Theory of the Stability of Motion. 1987, Moscow: Nauka. (in Russian); W Thomson, P Tait. Treatise on Natural Philosophy. Part Ⅰ. Cambridge University Press, 1879], are illustrated by an example.%讨论定常非完整系统在耗散、保守、循环力作用下的不稳定平衡问题.应用方法是基于运动微分方程解的存在性,当t→-∞时,系统渐近地趋于平衡状态.假定在平衡位置附近,动能、Reyleigh耗散函数、位置力都是无限可微函数.结果将通过一个实例说明.部分结果参见Kozlov V V.On the asymptotic motions of systems with dissipation.Prikl Math Mekh,1994,58(4):31-36.(in Russian):Merkin D R.Introduction to the Theory of the Stability of Motion.Moscow:Nauka,1987.(in Russian);Thomson W,Tait P.Treatise on Natural Philosophy,Part Ⅰ[M].Cambridge:Cambridge University Press,1879.

  19. Structural design of a newly developed pediatric circulatory assist device for Fontan circulation by using shape memory alloy fiber.

    Science.gov (United States)

    Shiraishi, Y; Sugai, T K; Tanaka, A; Yoshizawa, M; Yambe, T; Yamada, A; Omran, M H; Shiga, T; Kitano, T; Kamiya, K; Mochizuki, S; Miura, H; Homma, D; Yamagishi, M

    2011-01-01

    Total cavopulmonary connection (TCPC) is commonly applied for the surgical treatment of congenital heart disease such as single ventricle in pediatric patients. Patients with no ventricle in pulmonary circulation are treated along with Fontan algorithm, in which the systemic venous return is diverted directly to the pulmonary artery without passing through subpulmonary ventricle. In order to promote the pulmonary circulation after Fontan procedure, we developed a newly designed pulmonary circulatory assist device by using shape memory alloy fibers. We developed a pulmonary circulatory assist device as a non-blood contacting mechanical support system in pediatric patients with TCPC. The device has been designed to be installed like a cuff around the ePTFE TCPC conduit, which can contract from outside. We employed a covalent type functional anisotropic shape memory alloy fiber (Biometal, Toki Corporation, Tokyo Japan) as a servo actuator of the pulmonary circulatory assist device. The diameter of this fiber was 100 microns, and its contractile frequency was 2-3 Hz. Heat generation with electric current contracts these fibers and the conduit. The maximum contraction ratio of this fiber is about 7% in length. In order to extend its contractile ratio, we fabricated and installed mechanical structural units to control the length of fibers. In this study, we examined basic contractile functions of the device in the mock system. As a result, the internal pressure of the conduit increased to 63 mmHg by the mechanical contraction under the condition of 400 msec-current supply in the mock examination with the overflow tank of 10 mmHg loading.

  20. Business Management System Support Analysis

    Science.gov (United States)

    Parikh, Jay

    2008-01-01

    The purpose of this research project was to develop a searchable database compiled with internal and external audit findings/observations. The data will correspond to the findings and observations from the date of Center-wide implementation of the ISO 9001-2000 standard to the present (2003-2008). It was derived and extracted from several sources and was in multiple formats. Once extracted, categorization of the findings/observations would be possible. The final data was mapped to the ISO 9001-2000 standard with the understanding that it will be displayed graphically. The data will be used to verify trends, associate risks, and establish timelines to identify strengths and weaknesses to determine areas of improvement in the Kennedy Space Center Business Management System Internal Audit Program.

  1. Indonesian Earthquake Decision Support System

    CERN Document Server

    Warnars, Spits

    2010-01-01

    Earthquake DSS is an information technology environment which can be used by government to sharpen, make faster and better the earthquake mitigation decision. Earthquake DSS can be delivered as E-government which is not only for government itself but in order to guarantee each citizen's rights for education, training and information about earthquake and how to overcome the earthquake. Knowledge can be managed for future use and would become mining by saving and maintain all the data and information about earthquake and earthquake mitigation in Indonesia. Using Web technology will enhance global access and easy to use. Datawarehouse as unNormalized database for multidimensional analysis will speed the query process and increase reports variation. Link with other Disaster DSS in one national disaster DSS, link with other government information system and international will enhance the knowledge and sharpen the reports.

  2. Network support for system initiated checkpoints

    Science.gov (United States)

    Chen, Dong; Heidelberger, Philip

    2013-01-29

    A system, method and computer program product for supporting system initiated checkpoints in parallel computing systems. The system and method generates selective control signals to perform checkpointing of system related data in presence of messaging activity associated with a user application running at the node. The checkpointing is initiated by the system such that checkpoint data of a plurality of network nodes may be obtained even in the presence of user applications running on highly parallel computers that include ongoing user messaging activity.

  3. Closed-Loop Life Support Systems

    Science.gov (United States)

    Fisher, John W.

    2003-01-01

    Contents include the following: 1. Advanced life support requirements document-high level: (a) high level requirements and standards, (b) advanced life support requirements documents-air, food, water. 2. Example technologies that satisfy requrements: air system-carbon dioxide removal. 3. Air-sabatter. 4. International Space Station water treatment subsystem.5. Direct osmotic concentrator. 6. Mass, volume and power estimates.

  4. Decision support system for vehicle scheduling

    Directory of Open Access Journals (Sweden)

    C. Gaindric

    1999-08-01

    Full Text Available A decision support system (DSS is described to form schedules of traffic from a central warehouse to a set of consumers by cyclic routes. The system may be used by dispatchers at transportation enterprises. The system structure, short description of modules, and algorithms solving the originating problems are presented.

  5. Cell and Tissue Organization in the Circulatory and Ventilatory Systems Volume 1 Signaling in Cell Organization, Fate, and Activity, Part A Cell Structure and Environment

    CERN Document Server

    Thiriet, Marc

    2011-01-01

    The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning.  The present volume is devoted to cellular events that allow adaptation to environmental conditions, particularly mechanotransduction. It begins with cell organization and a survey of cell types in the vasculatur...

  6. Pathophysiological roles of peroxynitrite in circulatory shock.

    Science.gov (United States)

    Szabó, Csaba; Módis, Katalin

    2010-09-01

    Peroxynitrite is a reactive oxidant produced from nitric oxide and superoxide, which reacts with proteins, lipids, and DNA, and promotes cytotoxic and proinflammatory responses. Here, we overview the role of peroxynitrite in various forms of circulatory shock. Immunohistochemical and biochemical evidences demonstrate the production of peroxynitrite in various experimental models of endotoxic and hemorrhagic shock both in rodents and in large animals. In addition, biological markers of peroxynitrite have been identified in human tissues after circulatory shock. Peroxynitrite can initiate toxic oxidative reactions in vitro and in vivo. Initiation of lipid peroxidation, direct inhibition of mitochondrial respiratory chain enzymes, inactivation of glyceraldehyde-3-phosphate dehydrogenase, inhibition of membrane Na+/K+ ATPase activity, inactivation of membrane sodium channels, and other oxidative protein modifications contribute to the cytotoxic effect of peroxynitrite. In addition, peroxynitrite is a potent trigger of DNA strand breakage, with subsequent activation of the nuclear enzyme poly(ADP-ribose) polymerase, which promotes cellular energetic collapse and cellular necrosis. Additional actions of peroxynitrite that contribute to the pathogenesis of shock include inactivation of catecholamines and catecholamine receptors (leading to vascular failure) and endothelial and epithelial injury (leading to endothelial and epithelial hyperpermeability and barrier dysfunction), as well as myocyte injury (contributing to loss of cardiac contractile function). Neutralization of peroxynitrite with potent peroxynitrite decomposition catalysts provides cytoprotective and beneficial effects in rodent and large-animal models of circulatory shock.

  7. Flow Control of Closed Circulatory System for Solar Collector%太阳集热器闭式循环系统流量控制

    Institute of Scientific and Technical Information of China (English)

    张定学

    2011-01-01

    This paper describes the basic requirements for flow control of the thermal performance testing system of solar collector,then gives a control measure of the small flow in a closed loop control system, solves the bubble problem when the flow medium temperature rises significantly, proposes a way to measure the flow accurately. Practice shows that this flow control system has fast response, small overshoot, and high steady-state accuracy.%首先介绍太阳集热器热性能测试系统对流量控制的基本要求,然后给出一种闭式循环系统中小流量的控制方法,解决闭式循环系统中流动介质温度大幅度升高时产生汽泡的问题,提出一种精确测量流量的办法.实践表明,这种流量控制系统具有响应速度快、超调量小、稳态精度高的特点.

  8. INFORMATION SUPPORT SYSTEM OF MEDICAL SYSTEM RESEARCH

    Directory of Open Access Journals (Sweden)

    V. P. Martsenyuk

    2014-12-01

    Conclusions. The complex qualitative behavior of diseases models depending on parameters and controllers was observed in our investigation even without considering probabilistic nature of the majority of quantities and parameters of information models. KEY WORDS: data mining, system analysis, medical research, decision making

  9. Information Systems as Support to Corporate Management

    Directory of Open Access Journals (Sweden)

    Florida Veljanoska

    2013-12-01

    Full Text Available The idea of this paper is to introduce the great support of information systems to the management activities of a corporation. Information system as a combination of information technology and people’s actions that support operations, management and decision making, involves four major types of systems: Transaction Management System, Management Information System, Decision-Support System and Executive Support System, and with that it is able to entail and support all business activities. In traditional firms these systems tend to be isolated from one another, and information does not flow seamlessly from one end of the organization to the other. However, in contemporary digital firms, the different types of systems are closely linked to one another. Taking into account the main areas of an enterprise, viewed from a functional perspective; manufacturing and production, sales and marketing, finance and accounting and human resources, one of the major challenges that enterprises face today, is putting together data from all of the departments in order to make information flow across the enterprise. These changes require powerful new systems that can integrate information from many different functional areas and organizational unites and coordinate firm activities with those of suppliers and other business partners. Those new systems or applications, also called as enterprise applications help to unify the firm’s structure and organization, provides more efficient operations and customer-driven business processes, help in achieving great efficiencies by automating parts of processes, contribute to completely rethinking processes, assist in all levels of management and in the perspective of technology, the corporation is represented as a unified platform. Although there are several challenges to build these systems, we strongly believe that there are extraordinary opportunities to use information systems to achieve business value and increase

  10. Clinical decision support system in dental implantology

    OpenAIRE

    Alexandra Polášková; Jitka Feberová; Taťjána Dostálová; Pavel Kříž; Michaela Seydlová

    2013-01-01

    Implantology is rapidly developing interdisciplinary field providing enormous amounts of data to be classified, evaluated and interpreted. The analysis of clinical data remains a big challenge, because each new system has specific requirements. The aim of study was prepare specific tool for treatment planning. Decision support system is built on Expert system. It is interactive software which provides clinical recommendations and treatment planning. Expert systems are knowledge-based computer...

  11. A SWOT analysis of Planning Support Systems

    NARCIS (Netherlands)

    Vonk, G.; Geertman, S.; Schot, P.P.

    2007-01-01

    Insight into the strengths, weaknesses, opportunities, and threats (SWOT) of planning support systems (PSS) is fragmented between users and system developers. The lack of combined insights blocks development in the right direction and makes potential users hesitant to apply PSS in planning. This stu

  12. Panorama of Recommender Systems to Support Learning

    NARCIS (Netherlands)

    Drachsler, Hendrik; Verbert, Katrien; Santos, Olga C.; Manouselis, Nikos

    2015-01-01

    This chapter presents an analysis of recommender systems in TechnologyEnhanced Learning along their 15 years existence (2000-2014). All recommender systems considered for the review aim to support educational stakeholders by personalising the learning process. In this meta-review 82 recommender syst

  13. Intelligent tactical asset allocation support system

    NARCIS (Netherlands)

    Hiemstra, Y.

    1995-01-01

    This paper presents an advanced support system for Tactical Asset Allocation. Asset allocation explains over 90% of portfolio performance (Brinson, Hood and Beebower, 1988). Tactical asset allocation adjusts a strategic portfolio on the basis of short term market outlooks. The system includes apredi

  14. Decision support system for nursing management control

    Energy Technology Data Exchange (ETDEWEB)

    Ernst, C.J.

    1983-01-01

    A knowledge representation approach for expert systems supporting decision processes in business is proposed. A description of a knowledge representation schema using a logic programming metalanguage is described, then the role of such a schema in a management expert system is demonstrated through the problem of nursing management control in hospitals. 18 references.

  15. Normal behaviour of circulatory parameters during exercise. Reference values for heart rate and systemic blood pressure. The ECCIS Project data. Epidemiologia e Clinica della Cardiopatia Ischemica Silente.

    Science.gov (United States)

    Menghini, F; Dally, L; Fazzini, P F; Menotti, A; Prati, P L; Rovelli, F; Antoniucci, D; Seccareccia, F

    1995-08-01

    The study of simultaneous variations in heart rate (HR) and systemic blood pressure is of great interest in ergometric practice complementing the analysis of the ST segment by ECG. This paper examines data proceeding from 500 consecutive, normal, exercise stress tests with the aim of offering reference values on the step-by-step behaviour of HR, systolic and diastolic blood pressure (SBP, DBP) during exercise in a normal population. The sample comes from a large epidemiological study (ECCIS Project) conducted on 4842 healthy, working men, aged 40-59, which proposes to identify, by a 3 stage procedure, subjects with totally asymptomatic coronary artery disease (type I silent ischemia). A further aim of our paper is to examine the influence of some physiological variables (age, height, weight, body mass index, resting HR, SBP and DBP) on the response to effort of HR, SBP and DBP; reciprocal HR/SBP adjustment during exercise; maximal attained workload and recovery time. Due to a preliminary observation that the rate of step-by-step increase in HR and SBP is inversely related to total duration, the population was split into 4 groups according to exercise tolerance (defined by maximal attained workload) to elaborate reference values. Furthermore our data demonstrate that: 1) SBP increases more rapidly with respect to HR for older and heavier subjects; 2) Exercise tolerance is inversely related to age, baseline HR and SBP, and directly related to weight and height; 3) return to baseline conditions, during recovery, is quicker for subjects with better exercise tolerance and lower baseline HR, SBP and weight.

  16. Matrix metalloproteinase-2 functional promoter polymorphism G1575A is associated with elevated circulatory MMP-2 levels and increased risk of cardiovascular disease in systemic lupus erythematosus patients.

    Science.gov (United States)

    Bahrehmand, F; Vaisi-Raygani, A; Kiani, A; Rahimi, Z; Tavilani, H; Navabi, S J; Shakiba, E; Hassanzadeh, N; Pourmotabbed, T

    2012-05-01

    Matrix metalloproteinase-2 (MMP-2) is a zinc dependent endonuclease that degrades type IV collagen, the major structural component of basement membranes. MMP-2 functional promoter polymorphism G1575A affects circulating level of MMP-2 and may be considered an important genetic determinant of cardiovascular disease (CVD) in systemic lupus erythematosus (SLE) patients. In this study, association between MMP-2 1575A allele with serum MMP-2, neopterin and lipid-lipoprotein levels and with SLE and developing CVD was investigated. The present case-control study consisted of 109 SLE patients with and without CVD (mean age, 35.6 years) and 101 gender- and age-matched, unrelated, healthy controls (mean age, 37.1 years) from the population in the west of Iran. MMP-2 1575G/A polymorphism was detected by polymerase chain reaction (restriction fragment length polymorphism) PCR-RFLP, serum MMP-2, neopterin and lipid levels were determined by enzyme-linked immunosorbent assay (ELISA), high-performance liquid chromatography (HPLC) and enzyme assay, respectively. The presence of MMP-2 G1575A allele was found to be associated with SLE and developed CVD (OR = 1.78, p = 0.029 and OR = 3.43, p = 0.025, respectively). The SLE patients with MMP-2 A (G/A + A/A) allele had higher MMP-2 activity (301 ± 166 vs. 194 ± 35.5, p = 0.002), neopterin (29.4 ± 39.4 vs. 7.3 ± 4.6, p = 0.005), LDL-C (120 ± 25.7 vs. 87 ± 39.3, p = 0.045) and lower HDL-C (39.6 ± 11 vs. 45.9 ± 11.8, p = 0.031) levels than the control subjects. There was a significantly positive correlation between MMP-2 level with neopterin, total cholesterol and TG levels and negative correlation with HDL-C level in SLE patients with CVD. MMP-2 G1575A allele may be a risk factor for SLE. The carriers of this allele have high levels of MMP-2, neopterin, total cholesterol and TG and lower levels of HDL, thus, they are more likely to develop heart disease.

  17. System Design for Transitional Aircraft Support

    Directory of Open Access Journals (Sweden)

    John P.T. Mo

    2014-01-01

    Full Text Available The Australian Defence Force and industry are undergoing significant changes in the way they work together in capability enhancement programs. There are capability gaps in maintaining and supporting current obligations during major asset acquisition, which has migrated into the front line of Royal Air Force Fighter Groups as a new capability. This paper examines a steady state support solution and argues that in order to interchange from one support solution to a new architecture there must be a period for transition, which may need its own interim business model and operational service. A preliminary study of several existing support solutions reveals the generic elements that need to be parameterized and traced through the support system architecture trajectory.

  18. Support systems of the orbiting quarantine facility

    Science.gov (United States)

    The physical support systems, the personnel management structure, and the contingency systems necessary to permit the Orbiting Quarantine Facility (OQF) to function as an integrated system are described. The interactions between the subsystems within the preassembled modules are illustrated. The Power Module generates and distributes electrical power throughout each of the four modules, stabilizes the OQF's attitude, and dissipates heat generated throughout the system. The Habitation Module is a multifunctional structure designed to monitor and control all aspects of the system's activities. The Logistics Module stores the supplies needed for 30 days of operation and provides storage for waste materials generated during the mission. The Laboratory Module contains the equipment necessary for executing the protocol, as well as an independent life support system.

  19. An electronic voting system supporting vote weights

    OpenAIRE

    Eliasson, C.; Zúquete, A.

    2006-01-01

    Typically each voter contributes with one vote for an election. But there are some elections where voters can have different weights associated with their vote. In this paper we provide a solution for allowing an arbitrary number of weights and weight values to be used in an electronic voting system. We chose REVS, Robust Electronic Voting System, a voting system designed to support Internet voting processes, as the start point for studying the introduction of vote weights. To the best of our...

  20. Lunar Surface Systems Supportability Technology Development Roadmap

    Science.gov (United States)

    Oeftering, Richard C.; Struk, Peter M.; Green, Jennifer L.; Chau, Savio N.; Curell, Philip C.; Dempsey, Cathy A.; Patterson, Linda P.; Robbins, William; Steele, Michael A.; DAnnunzio, Anthony; Meseroll, Robert; Quiter, John; Shannon, Russell; Easton, John W.; Madaras, Eric I.; BrownTaminger, Karen M.; Tabera, John T.; Tellado, Joseph; Williams, Marth K.; Zeitlin, Nancy P.

    2011-01-01

    The Lunar Surface Systems Supportability Technology Development Roadmap is a guide for developing the technologies needed to enable the supportable, sustainable, and affordable exploration of the Moon and other destinations beyond Earth. Supportability is defined in terms of space maintenance, repair, and related logistics. This report considers the supportability lessons learned from NASA and the Department of Defense. Lunar Outpost supportability needs are summarized, and a supportability technology strategy is established to make the transition from high logistics dependence to logistics independence. This strategy will enable flight crews to act effectively to respond to problems and exploit opportunities in an environment of extreme resource scarcity and isolation. The supportability roadmap defines the general technology selection criteria. Technologies are organized into three categories: diagnostics, test, and verification; maintenance and repair; and scavenge and recycle. Furthermore, "embedded technologies" and "process technologies" are used to designate distinct technology types with different development cycles. The roadmap examines the current technology readiness level and lays out a four-phase incremental development schedule with selection decision gates. The supportability technology roadmap is intended to develop technologies with the widest possible capability and utility while minimizing the impact on crew time and training and remaining within the time and cost constraints of the program.

  1. PLM system support for modular product development

    DEFF Research Database (Denmark)

    Bruun, Hans Peter Lomholt; Mortensen, Niels Henrik; Harlou, Ulf

    2015-01-01

    is the description of an empirical tested approach using a visual product architecture representation in combination with a PLM system to support the development of a product family of products. The results from the study encompass new PLM capabilities for handling multiple product structures, visualising multiple......A modular design strategy both enables, but also demands, parallelism in design activities and collaboration between a diversity of disciplines in companies, which often involves supporting computer-based tools for enhancing interaction, design management, and communication. Product data management...... (PDM) and product lifecycle management (PLM) systems offer support by automating and managing some of the operational complexity of modular design activities. PLM system tools are used for handling a variety of product definitions, to manage workflow of development activities, and to measure relational...

  2. 分数因子与分数阶完整力学系统的运动方程和循环积分%Fractional Motion Equations and Circulatory Integrals of Holonomic Dynamical Systems with Fractional Gene

    Institute of Scientific and Technical Information of China (English)

    傅景礼; 郭玛丽

    2016-01-01

    Firstly,a fractional gene and a fractional increment are put forward and the definitions and properties of fractional derivative and integral with fractional gene are given.Secondly,the exchanging relationship between the isochronous variation and fractional derivative with the fractional gene is proved.Thirdly,the fractional Hamilton principles and fractional differential equations with fractional gene for holonomic dynamical systems are presented.Further,the fractional circulatory integrals of the systems are obtained and the fractional Routh's equations with fractional gene are derived.Finally,two examples are given.This research indicates that the fractional differential equations can become the conventional differential equations with fractional gene,and the general methods for solving the conventional differential equations are also applicable for solving the fractional differential equations.%引入分数因子和分数增量,给出了分数阶微积分的定义和性质;基于分数阶导数的定义,证明了含有分数因子的等时变分与分数阶算子的交换关系;提出了分数阶完整保守和非保守系统的Hamilton原理;建立了分数阶完整保守系统和非保守系统的运动微分方程;得到了分数阶完整保守系统的循环积分;并利用分数阶循环积分导出分数阶罗兹方程.最后给出了两个例子.研究表明利用分数因子给出的分数阶微分方程是一个含有分数因子的通常的微分方程,那么分数阶系统运动微分方程的求解都可以采用通常微分方程的求解方法.

  3. Using Visualization in Cockpit Decision Support Systems

    Energy Technology Data Exchange (ETDEWEB)

    Aragon, Cecilia R.

    2005-07-01

    In order to safely operate their aircraft, pilots must makerapid decisions based on integrating and processing large amounts ofheterogeneous information. Visual displays are often the most efficientmethod of presenting safety-critical data to pilots in real time.However, care must be taken to ensure the pilot is provided with theappropriate amount of information to make effective decisions and notbecome cognitively overloaded. The results of two usability studies of aprototype airflow hazard visualization cockpit decision support systemare summarized. The studies demonstrate that such a system significantlyimproves the performance of helicopter pilots landing under turbulentconditions. Based on these results, design principles and implicationsfor cockpit decision support systems using visualization arepresented.

  4. Circulatory Shock. Volume 27, Number 4, 1989

    Science.gov (United States)

    1990-02-01

    23 pg/ml by 180 min and plasma TNFct increased 852 ± 187 by 90 min, then rapidly returned to baseline. Following 45 min of eccentric exercise , which...sham operation (SO). Four weeks following AC, cardiac hypertrophy was evidenced by significantly elevated (pɘ.001) heart weight-to-body weight ratios...ratio of BE/BLPH during circulatory stress (i.e., hypertrophy ). The ratio of BE/BLPH in the heart varies independently of that in the plasma in AC

  5. Birds of a Feather: Supporting Secure Systems

    Energy Technology Data Exchange (ETDEWEB)

    Braswell III, H V

    2006-04-24

    Over the past few years Lawrence Livermore National Laboratory has begun the process of moving to a diskless environment in the Secure Computer Support realm. This movement has included many moving targets and increasing support complexity. We would like to set up a forum for Security and Support professionals to get together from across the Complex and discuss current deployments, lessons learned, and next steps. This would include what hardware, software, and hard copy based solutions are being used to manage Secure Computing. The topics to be discussed include but are not limited to: Diskless computing, port locking and management, PC, Mac, and Linux/UNIX support and setup, system imaging, security setup documentation and templates, security documentation and management, customer tracking, ticket tracking, software download and management, log management, backup/disaster recovery, and mixed media environments.

  6. Compactly Supported Curvelet-Type Systems

    DEFF Research Database (Denmark)

    Rasmussen, Kenneth Niemann; Nielsen, Morten

    2012-01-01

    We study a flexible method for constructing curvelet-type frames. These curvelet-type systems have the same sparse representation properties as curvelets for appropriate classes of smooth functions, and the flexibility of the method allows us to give a constructive description of how to construct...... curvelet-type systems with a prescribed nature such as compact support in direct space. The method consists of using the machinery of almost diagonal matrices to show that a system of curvelet molecules which is sufficiently close to curvelets constitutes a frame for curvelet-type spaces. Such a system...

  7. Clinical Productivity System - A Decision Support Model

    CERN Document Server

    Bennett, Casey C

    2012-01-01

    Purpose: This goal of this study was to evaluate the effects of a data-driven clinical productivity system that leverages Electronic Health Record (EHR) data to provide productivity decision support functionality in a real-world clinical setting. The system was implemented for a large behavioral health care provider seeing over 75,000 distinct clients a year. Design/methodology/approach: The key metric in this system is a "VPU", which simultaneously optimizes multiple aspects of clinical care. The resulting mathematical value of clinical productivity was hypothesized to tightly link the organization's performance to its expectations and, through transparency and decision support tools at the clinician level, affect significant changes in productivity, quality, and consistency relative to traditional models of clinical productivity. Findings: In only 3 months, every single variable integrated into the VPU system showed significant improvement, including a 30% rise in revenue, 10% rise in clinical percentage, a...

  8. A suction detection system for rotary blood pumps based on the Lagrangian support vector machine algorithm.

    Science.gov (United States)

    Wang, Yu; Simaan, Marwan A

    2013-05-01

    The Left Ventricular Assist Device (LVAD) is a rotary mechanical pump that is implanted in patients with congestive heart failure to help the left ventricle in pumping blood in the circulatory system. However, using such a device may result in a very dangerous event, called ventricular suction that can cause ventricular collapse due to overpumping of blood from the left ventricle when the rotational speed of the pump is high. Therefore, a reliable technique for detecting ventricular suction is crucial. This paper presents a new suction detection system that can precisely classify pump flow patterns, based on a Lagrangian Support Vector Machine (LSVM) model that combines six suction indices extracted from the pump flow signal to make a decision about whether the pump is in suction, approaching suction, or not in suction. The proposed method has been tested using in vivo experimental data based on two different pumps. The simulation results show that the system can produce superior performance in terms of classification accuracy, stability, learning speed, and good robustness compared to three other existing suction detection methods and the original SVM-based algorithm. The ability of the proposed algorithm to detect suction provides a reliable platform for the development of a feedback control system to control the speed of the pump while at the same time ensuring that suction is avoided.

  9. Supporting Classroom Activities with the BSUL System

    Science.gov (United States)

    Ogata, Hiroaki; Saito, Nobuji A.; Paredes J., Rosa G.; San Martin, Gerardo Ayala; Yano, Yoneo

    2008-01-01

    This paper presents the integration of ubiquitous computing systems into classroom settings, in order to provide basic support for classrooms and field activities. We have developed web application components using Java technology and configured a classroom with wireless network access and a web camera for our purposes. In this classroom, the…

  10. Unit 127 - Spatial Decision Support Systems

    OpenAIRE

    064, CC in GIScience; Malczewski, Jacek; Keller, C Peter

    2000-01-01

    This unit focuses on the concept of Spatial Decision Support Systems (SDSS). It covers the major characteristics of spatial decision problems; the decision-making process; a definition of SDSS; principles of SDSS; the dialog, data, model (DDM) paradigm; and technologies for developing SDSS.

  11. Nitrogenius: a nitrogen decision support system

    NARCIS (Netherlands)

    Erisman, J.W.; Hensen, A.; Vries, de W.; Kros, H.; Wal, van der T.; Winter, de W.; Wien, J.E.; Elswijk, van M.; Maat, M.; Sanders, K.

    2002-01-01

    A nitrogen decision support system in the form of a game (NitroGenius) was developed for the Second International Nitrogen Conference. The aims were to: i) improve understanding among scientists and policy makers about the complexity of nitrogen pollution problems in an area of intensive agricultura

  12. Circulatory abnormalities in cirrhosis with focus on neurohumoral aspects

    DEFF Research Database (Denmark)

    Møller, Søren; Henriksen, Jens Henrik

    1997-01-01

    Patients with cirrhosis exhibit characteristic hemodynamic changes with a hyperkinetic circulation and an abnormal distribution of the blood volume and neurohumoral regulation. Their plasma and noncentral blood volumes are increased, and the central and arterial blood volume and systemic vascular...... and hyperkinetic circulation in cirrhosis. Various vasodilators such as atrial natriurectic peptide, calcitonin gene-related peptide, adrenomedullin, and nitric oxide are among potential candidates in the arterial vasodilatation in cirrhosis. Besides enhanced sympathetic nervous activity, activation of the renin......-angiotensin-aldosterone system, and elevated circulating vasopressin, endothelin-1 may also be implicated in the hemodynamic counter-regulation in cirrhosis. Recent research has focused on the assertion that the hemodynamic and neurohumoral abnormalities in cirrhosis are part of a general circulatory dysfunction influencing...

  13. Impulse: Memory System Support for Scientific Applications

    Directory of Open Access Journals (Sweden)

    John B. Carter

    1999-01-01

    Full Text Available Impulse is a new memory system architecture that adds two important features to a traditional memory controller. First, Impulse supports application‐specific optimizations through configurable physical address remapping. By remapping physical addresses, applications control how their data is accessed and cached, improving their cache and bus utilization. Second, Impulse supports prefetching at the memory controller, which can hide much of the latency of DRAM accesses. Because it requires no modification to processor, cache, or bus designs, Impulse can be adopted in conventional systems. In this paper we describe the design of the Impulse architecture, and show how an Impulse memory system can improve the performance of memory‐bound scientific applications. For instance, Impulse decreases the running time of the NAS conjugate gradient benchmark by 67%. We expect that Impulse will also benefit regularly strided, memory‐bound applications of commercial importance, such as database and multimedia programs.

  14. Implementation of Business Game Activity Support System

    Institute of Scientific and Technical Information of China (English)

    TANABU Motonari

    2004-01-01

    Business game can be used not only as an educational tool for the development of decision making ability, but also can be used for supporting the knowledge creation activity in organizations. In this paper, some conceptual considerations to meanings of the business game in the knowledge creation activity by using the knowledge creation theory and other related theories are given,and business game activity concept which refers to game play and development is proposed. Then focusing on the business game activity as an instantiation of the knowledge creation activity, and a Web based gaming activity support system based on the former system called YBG that enables us to play and develop many business games through the standard web browser is proposed. This system also provides us a lot of opportunities to play and develop the business games over business game communities.

  15. Operator support system using computational intelligence techniques

    Energy Technology Data Exchange (ETDEWEB)

    Bueno, Elaine Inacio, E-mail: ebueno@ifsp.edu.br [Instituto Federal de Educacao, Ciencia e Tecnologia de Sao Paulo (IFSP), Sao Paulo, SP (Brazil); Pereira, Iraci Martinez, E-mail: martinez@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2015-07-01

    Computational Intelligence Systems have been widely applied in Monitoring and Fault Detection Systems in several processes and in different kinds of applications. These systems use interdependent components ordered in modules. It is a typical behavior of such systems to ensure early detection and diagnosis of faults. Monitoring and Fault Detection Techniques can be divided into two categories: estimative and pattern recognition methods. The estimative methods use a mathematical model, which describes the process behavior. The pattern recognition methods use a database to describe the process. In this work, an operator support system using Computational Intelligence Techniques was developed. This system will show the information obtained by different CI techniques in order to help operators to take decision in real time and guide them in the fault diagnosis before the normal alarm limits are reached. (author)

  16. Novel use of the AngioVac® system to remove thrombus during simultaneous extracorporeal membrane oxygenation life support.

    Science.gov (United States)

    Griffith, Kevin E; Jenkins, Eric; Copenhaver, William; Williams, David M

    2016-03-01

    Extracorporeal membrane oxygenation (ECMO) was introduced to clinical medicine over 40 years ago. While initially used as a treatment for acute respiratory failure in infants, the use of ECMO has grown to include respiratory and circulatory failure in both children and adults, cardiogenic shock, pulmonary embolism, sepsis, trauma, malignancy, pulmonary hemorrhage and as a treatment for hypothermic drowning.(1) Recent technological improvements in ECMO circuitry make it possible to minimize anticoagulation of the ECMO patient, decreasing the incidence of bleeding. Thrombus deposition within the ECMO circuit can be a life-threating complication. ECMO circuit thrombus can be contained in the circuit, adherent to cannula and deposited within the patient. The ability to remove thrombus while the patient remains on ECMO support could be a life-saving measure for some patients. The present case report outlines use of the AngioVac(®) thrombus removal system in concert with ECMO to remove a large thrombus adherent to an ECMO cannula.

  17. DAB: Multiplex and system support features

    Science.gov (United States)

    Riley, J. L.

    This Report describes the multiplex and system support features of the Eureka 147/DAB digital audio system. It sets out the requirements of all users along the broadcast chain from service providers and broadcaster through to the listener. The contents of the transmission frame are examined drawing the distinction between the main service multiplex and the provision of control information in a separate fast data channel. The concept of the DAB service structure is introduced and the inherent system flexibility for altering the service arrangement is explained. A wide range of service information features builds on those provided in earlier systems, such as RDS (Radio Data System) and is intended to make it easier for a listener to find any required service and to add a further dimension to audio broadcasting. The choices available to users in all of these areas are examined.

  18. DECISION SUPPORT SYSTEMS FOR LOGISTICS MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Pere Tumbas

    2007-12-01

    Full Text Available The environment where managers make decisions has been significantly changed ttiese years. Today, organizations design their products in one country, purchase of materials and raw materials in the other one, production is done in the third country, and finished products are brought out in many countries in the world. Logistics, as a transaction intensive function mutually connect these substantially different business processes and enables more effective and efficient management of the long logistics chains. In realizing such a task, the intensive use of infomiation technologies that provide timely transaction processing and give support in decisionmaking processes is especially important for logistics. The work reviews information systems development in the field of logistics, and a special attention is paid to the conceptual level of the global structure in decision support systems (DSS. Possible contents of identified subsystems are cited and potential development trends of its application are discussed.

  19. Strategic Defense System; Integrated Logistics Support Plan.

    Science.gov (United States)

    2007-11-02

    WEAPONS SBI SBL GBL NPB iiiwiiiii BSTS SSTS AOS CC/SOIF NTB :-.’-’\\.;v::v-X’X:.’:^v::v:.-:vS...Validation of test methods C. Evaluate test results IV. Simulation and Modelling A. Methodology B. Requirements C. Validation D. National Test Bed n...equipment and the systems they support; - On-the-job training capabilities incorporated in the prime equipment design as a method of reducing the need

  20. A COMPUTERIZED OPERATOR SUPPORT SYSTEM PROTOTYPE

    Energy Technology Data Exchange (ETDEWEB)

    Thomas A. Ulrich; Roger Lew; Ronald L. Boring; Ken Thomas

    2015-03-01

    A computerized operator support system (COSS) is proposed for use in nuclear power plants to assist control room operators in addressing time-critical plant upsets. A COSS is a collection of technologies to assist operators in monitoring overall plant performance and making timely, informed decisions on appropriate control actions for the projected plant condition. A prototype COSS was developed in order to demonstrate the concept and provide a test bed for further research. The prototype is based on four underlying elements consisting of a digital alarm system, computer-based procedures, piping and instrumentation diagram system representations, and a recommender module for mitigation actions. The initial version of the prototype is now operational at the Idaho National Laboratory using the Human System Simulation Laboratory.

  1. Dispositivo de assistência circulatória mecânica intraventricular de fluxo axial: estudo in vitro In vitro evaluation of an intraventricular axial flow pump for mechanical circulatory support

    Directory of Open Access Journals (Sweden)

    Luiz Fernando KUBRUSLY

    2000-06-01

    Full Text Available É apresentado estudo in vitro de um dispositivo de assistência circulatória totalmente implantável no ventrículo esquerdo, de fluxo axial e de tamanho pequeno (30 cc - 7 cm comprimento. Apesar dessas características foi capaz de gerar fluxos entre 5 - 8 l/min com motor, operando em 8 W, sem causar hemólise em período de até 12 horas. O custo de produção, excetuando-se o sistema de baterias, foi projetado entre 5 - 8 mil dólares, o que o torna viável para utilização clínica rotineira em nosso país.We are currently studying an intraventricular axial flow blood pump in vitro. It is designed for long term left ventricular support. The small (30 cc, 7 cm length was capable of producing flows of 5 - 8 l/min on a 8 W motor, with no device related hemolysis throughout the 12 h of the study. The cost of production, except for the batteries, has been estimated at between 5 - 8 thousand dollars, a reasonable amount for routine clinical use in Brazil.

  2. Post Disaster Assessment with Decision Support System

    Directory of Open Access Journals (Sweden)

    May Florence J. Franco

    2016-05-01

    Full Text Available The study aimed to develop an online system that would expedite the response of agencies after disaster strikes; generate a list of the kinds and volume of relief aids needed per family affected for a fair, precise and timely distribution; implement community-based ICT by remotely gathering all the necessary data needed for disaster assessment; and adhere to ISO 9126 standards. The system was designed to calculate the effects of disaster in human lives and economy. Integrated into the system were Goggle Maps, Mines and GeoSciences Bureau Hazard Maps, SMS sending features, best passable routes calculations, and decision support on the needs that has to be addressed. The system was made live at pdrrmcguimaras.herokuapp.com to allow remote data entry. The functionality and usability of the system were evaluated by 19 potential users by computing for the arithmetic Mean and Standard Deviation of the survey. The result showed that most of them strongly agreed that the system is acceptable based on these criteria. A group of IT experts also evaluated the system’s conformance to ISO 9126 standards using the same method. The result showed that majority of them strongly agreed that the system conforms to this international standard. The system is seen as a valuable tool for the Provincial Disaster Risk Reduction Management Council (PDRRMC and the National Disaster Risk Reduction Management Council (NDRRMC for it could help expedite the assessment of the effects of disasters and the formulation of response plans and strategies.

  3. Environmental Control and Life Support System Mockup

    Science.gov (United States)

    2001-01-01

    The Environmental Control and Life Support System (ECLSS) Group of the Flight Projects Directorate at the Marshall Space Flight Center in Huntsville, Alabama, is responsible for designing and building the life support systems that will provide the crew of the International Space Station (ISS) a comfortable environment in which to live and work. This photograph shows the mockup of the the ECLSS to be installed in the Node 3 module of the ISS. From left to right, shower rack, waste management rack, Water Recovery System (WRS) Rack #2, WRS Rack #1, and Oxygen Generation System (OGS) rack are shown. The WRS provides clean water through the reclamation of wastewaters and is comprised of a Urine Processor Assembly (UPA) and a Water Processor Assembly (WPA). The UPA accepts and processes pretreated crewmember urine to allow it to be processed along with other wastewaters in the WPA. The WPA removes free gas, organic, and nonorganic constituents before the water goes through a series of multifiltration beds for further purification. The OGS produces oxygen for breathing air for the crew and laboratory animals, as well as for replacing oxygen loss. The OGS is comprised of a cell stack, which electrolyzes (breaks apart the hydrogen and oxygen molecules) some of the clean water provided by the WRS, and the separators that remove the gases from the water after electrolysis.

  4. Hail Disrometer Array for Launch Systems Support

    Science.gov (United States)

    Lane, John E.; Sharp, David W.; Kasparis, Takis C.; Doesken, Nolan J.

    2008-01-01

    Prior to launch, the space shuttle might be described as a very large thermos bottle containing substantial quantities of cryogenic fuels. Because thermal insulation is a critical design requirement, the external wall of the launch vehicle fuel tank is covered with an insulating foam layer. This foam is fragile and can be damaged by very minor impacts, such as that from small- to medium-size hail, which may go unnoticed. In May 1999, hail damage to the top of the External Tank (ET) of STS-96 required a rollback from the launch pad to the Vehicle Assembly Building (VAB) for repair of the insulating foam. Because of the potential for hail damage to the ET while exposed to the weather, a vigilant hail sentry system using impact transducers was developed as a hail damage warning system and to record and quantify hail events. The Kennedy Space Center (KSC) Hail Monitor System, a joint effort of the NASA and University Affiliated Spaceport Technology Development Contract (USTDC) Physics Labs, was first deployed for operational testing in the fall of 2006. Volunteers from the Community Collaborative Rain. Hail, and Snow Network (CoCoRaHS) in conjunction with Colorado State University were and continue to be active in testing duplicate hail monitor systems at sites in the hail prone high plains of Colorado. The KSC Hail Monitor System (HMS), consisting of three stations positioned approximately 500 ft from the launch pad and forming an approximate equilateral triangle (see Figure 1), was deployed to Pad 39B for support of STS-115. Two months later, the HMS was deployed to Pad 39A for support of STS-116. During support of STS-117 in late February 2007, an unusual hail event occurred in the immediate vicinity of the exposed space shuttle and launch pad. Hail data of this event was collected by the HMS and analyzed. Support of STS-118 revealed another important application of the hail monitor system. Ground Instrumentation personnel check the hail monitors daily when a

  5. JPSS Common Ground System Multimission Support

    Science.gov (United States)

    Jamilkowski, M. L.; Miller, S. W.; Grant, K. D.

    2013-12-01

    NOAA & NASA jointly acquire the next-generation civilian operational weather satellite: Joint Polar Satellite System (JPSS). JPSS contributes the afternoon orbit & restructured NPOESS ground system (GS) to replace the current Polar-orbiting Operational Environmental Satellite (POES) system run by NOAA. JPSS sensors will collect meteorological, oceanographic, climatological & solar-geophysical observations of the earth, atmosphere & space. The JPSS GS is the Common Ground System (CGS), consisting of Command, Control, & Communications (C3S) and Interface Data Processing (IDPS) segments, both developed by Raytheon Intelligence, Information & Services (IIS). CGS now flies the Suomi National Polar-orbiting Partnership (S-NPP) satellite, transfers its mission data between ground facilities and processes its data into Environmental Data Records for NOAA & Defense (DoD) weather centers. CGS will expand to support JPSS-1 in 2017. The JPSS CGS currently does data processing (DP) for S-NPP, creating multiple TBs/day across over two dozen environmental data products (EDPs). The workload doubles after JPSS-1 launch. But CGS goes well beyond S-NPP & JPSS mission management & DP by providing data routing support to operational centers & missions worldwide. The CGS supports several other missions: It also provides raw data acquisition, routing & some DP for GCOM-W1. The CGS does data routing for numerous other missions & systems, including USN's Coriolis/Windsat, NASA's SCaN network (including EOS), NSF's McMurdo Station communications, Defense Meteorological Satellite Program (DMSP), and NOAA's POES & EUMETSAT's MetOp satellites. Each of these satellite systems orbits the Earth 14 times/day, downlinking data once or twice/orbit at up to 100s of MBs/second, to support the creation of 10s of TBs of data/day across 100s of EDPs. Raytheon and the US government invested much in Raytheon's mission-management, command & control and data-processing products & capabilities. CGS's flexible

  6. Repulsive force support system feasibility study

    Science.gov (United States)

    Boom, R. W.; Abdelsalam, M. K.; Eyssa, Y. M.; Mcintosh, G. E.

    1987-01-01

    A new concept in magnetic levitation and control is introduced for levitation above a plane. A set of five vertical solenoid magnets mounted flush below the plane supports and controls the model in five degrees of freedom. The compact system of levitation coils is contained in a space 2.4 m (96 in) diameter by 1 m (40 in) deep with the top of the levitation system 0.9 m (36 in) below the center line of the suspended model. The levitated model has a permanent magnet core held in position by the five parallel superconductive solenoids symmetrically located in a circle. The control and positioning system continuously corrects for model position in five dimensions using computer current pulses superimposed on the levitation coil base currents. The conceptual designs include: superconductive and Nd-Fe-B permanent magnet model cores and levitation solenoids of either superconductive, cryoresistive, or room temperature windings.

  7. Decision Support System for Fighter Pilots

    DEFF Research Database (Denmark)

    Randleff, Lars Rosenberg

    2007-01-01

    During a mission over enemy territory a fighter aircraft may be engaged by ground based threats. The pilot can use different measures to avoid the aircraft from being detected by e.g. enemy radar systems. If the enemy detects the aircraft a missile may be fired to seek and destroy the aircraft...... and countermeasures that can be applied to mitigate threats. This work is concerned with finding proper evasive actions when a fighter aircraft is engaged by ground based threats. To help the pilot in deciding on these actions a decision support system may be implemented. The environment in which such a system must...... platforms (aircraft, ships, etc.) is described. Different approaches to finding the combination of countermeasures and manoeuvres improving the pilots survivability is investigated. During training a fighter pilot will learn a set of rules to follow when threat occurs. For the pilot these rules...

  8. Ontology Supported Information Systems: A Review

    Directory of Open Access Journals (Sweden)

    Padmavathi, T.

    2014-12-01

    Full Text Available The exponential growth of information on the web far exceeds the capacity of present day information retrieval systems and search engines, making information integration on the web difficult. In order to overcome this, semantic web technologies were proposed by the World Wide Web Consortium (W3C to achieve a higher degree of automation and precision in information retrieval systems. Semantic web, with its promise to deliver machine understanding to the traditional web, has attracted a significant amount of research from academia as well as from industries. Semantic web is an extension of the current web in which data can be shared and reused across the internet. RDF and ontology are two essential components of the semantic web architecture which support a common framework for data storage and representation of data semantics, respectively. Ontologies being the backbone of semantic web applications, it is more relevant to study various approaches in their application, usage, and integration into web services. In this article, an effort has been made to review the research work being undertaken in the area of design and development of ontology supported information systems. This paper also briefly explains the emerging semantic web technologies and standards.

  9. Reactive Software Agent Anesthesia Decision Support System

    Directory of Open Access Journals (Sweden)

    Grant H. Kruger

    2011-12-01

    Full Text Available Information overload of the anesthesiologist through technological advances have threatened the safety of patients under anesthesia in the operating room (OR. Traditional monitoring and alarm systems provide independent, spatially distributed indices of patient physiological state. This creates the potential to distract caregivers from direct patient care tasks. To address this situation, a novel reactive agent decision support system with graphical human machine interface was developed. The system integrates the disparate data sources available in the operating room, passes the data though a decision matrix comprising a deterministic physiologic rule base established through medical research. Patient care is improved by effecting change to the care environment by displaying risk factors and alerts as an intuitive color coded animation. The system presents a unified, contextually appropriate snapshot of the patient state including current and potential risk factors, and alerts of critical patient events to the operating room team without requiring any user intervention. To validate the efficacy of the system, a retrospective analysis focusing on the hypotension rules were performed. Results show that even with vigilant and highly trained clinicians, deviations from ideal patient care exist and it is here that the proposed system may allow more standardized and improved patient care and potentially outcomes.

  10. THE RESULTS OF MECHANICAL HEART SUPPORT SYSTEMS «INCOR» IMPLANTATION

    Directory of Open Access Journals (Sweden)

    A. M. Cherniavskiy

    2013-01-01

    Full Text Available The aim of investigation isestimation of mechanical heart support system «INCOR» implantation efficacy. Materials and methods. The Institute of Circulation Pathology has clinical experience of mechanical circulatory support systems «INCOR» (Berlin Heart AG implantation in 12 patients (10 men and 2 women with severe heart failure during the period from November 2006 to October 2012. The main indication for the use of mechanical support of the left ventricle was a left ventricular failure with marked dilatation of the left heart: end-diastolic volume (EDV, LV – 283 ± 58 ml, end-systolic volume (ESV – 233 ± 57 ml, ejection fraction (EF – 16 ± 7%, with preserved function of the right ventricle (RV (RV ejection fraction 35 ± 12%. Results. All patients showed a significant improvement in central hemodynamics in early postoperative period, reducing the volume of the heart chambers: LV EDV from 283 ± 58 to 183 ± 94 ml; LV ESV with 234 ± 57 to 157 ± 65 ml, increased right ventricular ejection fraction (RV EF (from 35 ± 12 to 43 ± 17%. Improve the function of the right ventricle oc- curred mainly due to the expense of left ventricular unloading and pulmonary circulation. In addition, there was a significant improvement in clinical status of patients – regression of symptoms of heart failure, a recovery of the liver and kidney function. Despite the ongoing anticoagulation and antiplatelet therapy under constant parameters of coagulation, there was some complications. Uterine bleeding occurred in 1 patient (16.6%, which required the abolition of anticoagulants and antiplatelet, uterine artery embolization, and as a result has led to thrombosis and stop system «INCOR». Four patients (33.3% had severe thromboembolic complications – acute cerebrovascular accident (CVA. In 1 patient (8% there was a hemorrhagic stroke due to rupture of intracerebral aneurysms with a breakthrough into the lateral ventricle of the brain. In 3 patients (25

  11. Senescent Changes in Cerebrospinal Fluid Circulatory Physiology and Their Role in the Pathogenesis of Normal-tension Glaucoma

    NARCIS (Netherlands)

    Wostyn, Peter; De Groot, Veva; Van Dam, Debby; Audenaert, Kurt; De Deyn, Peter Paul

    2013-01-01

    PURPOSE: To evaluate the evidence supporting a role for senescent changes in cerebrospinal fluid (CSF) circulatory physiology in the pathogenesis of normal-tension glaucoma (NTG). DESIGN: Literature review and personal perspective of the authors. METHODS: Analysis of selected articles in the peer-re

  12. Clinical decision support system in dental implantology

    Directory of Open Access Journals (Sweden)

    Alexandra Polášková

    2013-06-01

    Full Text Available Implantology is rapidly developing interdisciplinary field providing enormous amounts of data to be classified, evaluated and interpreted. The analysis of clinical data remains a big challenge, because each new system has specific requirements. The aim of study was prepare specific tool for treatment planning. Decision support system is built on Expert system. It is interactive software which provides clinical recommendations and treatment planning. Expert systems are knowledge-based computer programs designed to provide assistance in diagnosis and treatment planning. These systems are used for health care (dentistry, medicine, pharmacy etc.. The application contained the medical history analysis to obtaining information useful in formulating a diagnosis and providing implant insertion and prosthetic reconstruction to the patient; the diagnostic examination of dental implant procedure; implant positioning diagnosis – 3-D measurement; diagnostic information for treatment planning; treatment plan in the form of objective measurement of implant placement that helps surgeon and prosthodontics. The decision algorithm implemented by programming language is used. Core of program is an expert knowledge programming like a decision tree. The analysis of the decision-making process for implant treatment in general practice is prepared and analyzed.

  13. Inherent robust stability of driver support systems

    Institute of Scientific and Technical Information of China (English)

    王龙; J.; Ackermann

    1999-01-01

    Presented are the fact that the transfer function from the front steering angle to yaw rate is strictly positive real, irrespective of the uncertain mass and uncertain velocity, how to determine the positivity margin for this transfer function (some stabilization results are obtained), and how to check the positivity of a controller family. Furthermore,by exploiting the intrinsic structure of system equations and uncertainties, a nonconservative PID stabilization criterion for driver support systems is established. Some interesting results on positivity and connections of PID controllers are shown. Finally, some extreme point results on PID α-stabilization are obtained. These results give certain explanations and justifications for the simulation results performed at German Aerospace Research Center.

  14. Complexity in electronic negotiation support systems.

    Science.gov (United States)

    Griessmair, Michele; Strunk, Guido; Vetschera, Rudolf; Koeszegi, Sabine T

    2011-10-01

    It is generally acknowledged that the medium influences the way we communicate and negotiation research directs considerable attention to the impact of different electronic communication modes on the negotiation process and outcomes. Complexity theories offer models and methods that allow the investigation of how pattern and temporal sequences unfold over time in negotiation interactions. By focusing on the dynamic and interactive quality of negotiations as well as the information, choice, and uncertainty contained in the negotiation process, the complexity perspective addresses several issues of central interest in classical negotiation research. In the present study we compare the complexity of the negotiation communication process among synchronous and asynchronous negotiations (IM vs. e-mail) as well as an electronic negotiation support system including a decision support system (DSS). For this purpose, transcripts of 145 negotiations have been coded and analyzed with the Shannon entropy and the grammar complexity. Our results show that negotiating asynchronically via e-mail as well as including a DSS significantly reduces the complexity of the negotiation process. Furthermore, a reduction of the complexity increases the probability of reaching an agreement.

  15. MOODLE – COMPUTERIZED DISTANT LEARNING SUPPORT SYSTEM

    Directory of Open Access Journals (Sweden)

    V. A. Tunda

    2014-01-01

    Full Text Available Moodle (Modular Object-Oriented Dynamic Learning Environment is the system developed by the English-speaking community around the world for more than 10 years, supports both, offline and online training. In most cases, Moodle is used to support and connect learning face-to-face with online training, as well as with other types of learning. Moodle allows you to ask all sorts of questions and assess responses in a variety of ways. The central concept of Moodle is a course in which one or more teachers offer students resources (such as files, folders, Web pages and participate in interactive activities (such as forums, wikis, blogging, lessons, seminars, assignments, examinations. Students and teachers can change roles, mutually assess each other, share knowledge on the topics of study in the glossary and database system.In the English-speaking world, there are public sites with detailed documentation on Moodle, which is constantly verified and modified in accordance with emerging new versions of the system; Russian versions do not have public sites with detailed translation of the English-language documentation. On what and to whom you want to perform actions in the daily practice of the modern versions, only the barest of outlines on paid seminars and presentations to those who started the implementation of Moodle in your organization are given. And this despite the fact that the system has a great variety of Moodle (over 500 settings with different levels of functionality to be performed, to maintain and develop specially organized by the team of specialists. The question is not only about creating a training course in Moodle. It's about maintaining the health of the system within the institution, such as a University. Under the "health maintenance" means: availability and preservation of up-to-date documentation on system and manuals on Moodle separately for administrators, managers, teachers and students at their level, training consultants

  16. The CIHR Circulatory and Respiratory Health Institute

    Directory of Open Access Journals (Sweden)

    Malcolm King

    2000-01-01

    Full Text Available The Canadian Institutes of Health Research (CIHR was officially established on June 7, 2000. Among the 13 institutes that were created, the Institute for Circulatory and Respiratory Health (C&R or CnR, which brings together researchers in the fields of heart, stroke, lung and blood research, has become the principal outlet for respiratory research in this country. Although this large, combined institute was not the first choice of our society or of the respiratory research community at large, we must respect this choice within the context of the new direction for Canadian health research and help to make it work. Over this past summer, the process of recruiting the scientific directors and advisory board members for each CIHR institute has proceeded at a rapid pace. As we go to press, the decisions on the appointment of the 13 inaugural scientific directors are being made. In addition, over the next few weeks, the institute advisory boards will be appointed. The CIHR Governing Council has the ultimate responsibility for these appointments. The Council represents a very broad cross-section of the health research community in Canada; all of us on the Council sincerely wish to see the very best team of directors and board members selected to fulfill these roles.

  17. Essential Support Systems for Emerging Physics Teachers

    Science.gov (United States)

    Luttrell-Montes, Sally

    2006-12-01

    The University of Washington is one of eleven sites across the country participating in a Carnegie-funded project called Teachers for a New Era, which has a focus on renewing teacher preparation--from the undergraduate phase through the first five years of a teacher’s career. What happens at the preservice phase, especially during student teaching, is critical in laying the foundation for successful classroom teaching during the early career years. For the emerging physics teacher, having a cooperating teacher and university supervisor who have deep content/pedagogical knowledge within the discipline is ideal but providing specific supports and appropriate feedback are also necessary. During this talk, we will explore the value of a teacher continuum for emerging physics teachers and the kinds of experiences, structures, and feedback mechanisms the UW Teacher Education Program provides through the cooperating teachers and university supervisors to encourage alignment to reformed physics curriculum--using face-to-face interactions, dilemma-based protocols, documentation, and new possibilities for online support systems.

  18. Embedded systems for supporting computer accessibility.

    Science.gov (United States)

    Mulfari, Davide; Celesti, Antonio; Fazio, Maria; Villari, Massimo; Puliafito, Antonio

    2015-01-01

    Nowadays, customized AT software solutions allow their users to interact with various kinds of computer systems. Such tools are generally available on personal devices (e.g., smartphones, laptops and so on) commonly used by a person with a disability. In this paper, we investigate a way of using the aforementioned AT equipments in order to access many different devices without assistive preferences. The solution takes advantage of open source hardware and its core component consists of an affordable Linux embedded system: it grabs data coming from the assistive software, which runs on the user's personal device, then, after processing, it generates native keyboard and mouse HID commands for the target computing device controlled by the end user. This process supports any operating system available on the target machine and it requires no specialized software installation; therefore the user with a disability can rely on a single assistive tool to control a wide range of computing platforms, including conventional computers and many kinds of mobile devices, which receive input commands through the USB HID protocol.

  19. NASA Advanced Explorations Systems: Advancements in Life Support Systems

    Science.gov (United States)

    Shull, Sarah A.; Schneider, Walter F.

    2016-01-01

    The NASA Advanced Exploration Systems (AES) Life Support Systems (LSS) project strives to develop reliable, energy-efficient, and low-mass spacecraft systems to provide environmental control and life support systems (ECLSS) critical to enabling long duration human missions beyond low Earth orbit (LEO). Highly reliable, closed-loop life support systems are among the capabilities required for the longer duration human space exploration missions assessed by NASA's Habitability Architecture Team (HAT). The LSS project is focused on four areas: architecture and systems engineering for life support systems, environmental monitoring, air revitalization, and wastewater processing and water management. Starting with the international space station (ISS) LSS systems as a point of departure (where applicable), the mission of the LSS project is three-fold: 1. Address discrete LSS technology gaps 2. Improve the reliability of LSS systems 3. Advance LSS systems towards integrated testing on the ISS. This paper summarized the work being done in the four areas listed above to meet these objectives. Details will be given on the following focus areas: Systems Engineering and Architecture- With so many complex systems comprising life support in space, it is important to understand the overall system requirements to define life support system architectures for different space mission classes, ensure that all the components integrate well together and verify that testing is as representative of destination environments as possible. Environmental Monitoring- In an enclosed spacecraft that is constantly operating complex machinery for its own basic functionality as well as science experiments and technology demonstrations, it's possible for the environment to become compromised. While current environmental monitors aboard the ISS will alert crew members and mission control if there is an emergency, long-duration environmental monitoring cannot be done in-orbit as current methodologies

  20. GIS as spatial decision support system

    Directory of Open Access Journals (Sweden)

    V. Vostrovský

    2011-06-01

    Full Text Available This paper describes the possibility of the Geographic Information Systems (GIS as a means to support decision making in solving spatial problems. Spatial problems accompany every human activity, of which agriculture is no exception. The solutions to these problems requires the application of available knowledge in the relevant decision-making processes. GISs integrate hardware, software, and data for capturing, managing, analyzing, and displaying all forms of geographically referenced information. Coupled with GISs, geography helps to better understand and apply geographic knowledge to a host of global problems (unemployment, environmental pollution, the loss of arable land, epidemics etc.. The result may be a geographical approach represents a new way of thinking and solutions to existing spatial problems. This approach allows to apply existing knowledge to model and analyze these problems and thus help to solve them.

  1. Composting in advanced life support systems

    Science.gov (United States)

    Atkinson, C. F.; Sager, J. C.; Alazraki, M.; Loader, C.

    1998-01-01

    Space missions of extended duration are currently hampered by the prohibitive costs of external resupply. To reduce the need for resupply, the National Aeronautics and Space Administration (NASA) is currently testing methods to recycle solid wastes, water, and air. Composting can be an integral part of a biologically based waste treatment/recycling system. Results indicate that leachate from composted plant wastes is not inhibitory to seed germination and contains sufficient inorganic minerals to support plant growth. Other solid wastes, for example kitchen (food) wastes and human solid wastes, can be composted with inedible plant residues to safely reduce the volume of the wastes and levels of microorganisms potentially pathogenic to humans. Finished compost could serve as a medium for plant growth or mushroom production.

  2. Optimization of life support systems and their systems reliability

    Science.gov (United States)

    Fan, L. T.; Hwang, C. L.; Erickson, L. E.

    1971-01-01

    The identification, analysis, and optimization of life support systems and subsystems have been investigated. For each system or subsystem that has been considered, the procedure involves the establishment of a set of system equations (or mathematical model) based on theory and experimental evidences; the analysis and simulation of the model; the optimization of the operation, control, and reliability; analysis of sensitivity of the system based on the model; and, if possible, experimental verification of the theoretical and computational results. Research activities include: (1) modeling of air flow in a confined space; (2) review of several different gas-liquid contactors utilizing centrifugal force: (3) review of carbon dioxide reduction contactors in space vehicles and other enclosed structures: (4) application of modern optimal control theory to environmental control of confined spaces; (5) optimal control of class of nonlinear diffusional distributed parameter systems: (6) optimization of system reliability of life support systems and sub-systems: (7) modeling, simulation and optimal control of the human thermal system: and (8) analysis and optimization of the water-vapor eletrolysis cell.

  3. Proactive Decision Support Via Narrative-Integrated Multi-Level Support System (NIMSS)

    Science.gov (United States)

    2014-11-30

    30/2014 Final Report 07/11/2014 - 11/30/2014 Final Report - Proactive Decision Support Via Narrative -Integrated Multi-Level Support System (NIMSS...think, demonstrated via a realistic Naval/Marine Corps warfighting domain. Context-driven decision making; proactive decision support; narrative ...0005, CDRL B001 Proactive Decision Support via Narrative -Integrated Multi-level Support System (NIMSS) CHI Project # 14002 Purchase Order: N00014

  4. Circular pump support of blood circulation in the human body

    Science.gov (United States)

    Medvedev, A. E.; Fomin, V. M.; Prikhodko, Yu. M.; Cherniavskiy, A. M.; Fomichev, V. P.; Fomichev, A. V.; Chekhov, V. P.; Ruzmatov, T. M.

    2016-10-01

    The need of circulatory support systems in the treatment of chronic heart failure is increasing constantly, as 20% of patients in the waiting list die every year. Despite the great need for mechanical heart support systems, using of available systems is limited by the expensiveness. In addition, there is no one system that is 100% responsible to all medical and technical requirements, and would be completely safe for patient. Therefore, further research in the field of circu-latory support systems, considering health and technical requirements is relevant. One of the new directions in the study are disc pumps of viscous friction for liquid transporting, based on the Tesla pump principle. The operation principle of pumps based on the phenomenon of the boundary layer which is formed on the disk rotating in a fluid. There are experimental studies results of models with different variants of the rotor suspension, the various forms and the number of disks, forms the pump housing. However, none of the above samples was not brought to clinical trials. Furthermore, despite the promise of this model is still used today in some circulatory support systems are no similar type pump. Published data provide a basis for further development and testing of the pump model and allow to hope for leveling a number of significant shortcomings of modern left ventricular bypass systems.

  5. The organ preservation and enhancement of donation success ratio effect of extracorporeal membrane oxygenation in circulatory unstable brain death donor.

    Science.gov (United States)

    Fan, Xiaoli; Chen, Zhiquan; Nasralla, David; Zeng, Xianpeng; Yang, Jing; Ye, Shaojun; Zhang, Yi; Peng, Guizhu; Wang, Yanfeng; Ye, Qifa

    2016-10-01

    Between 2010 and 2013, we recorded 66 cases of failed organ donation after brain death (DBD) due to the excessive use of the vasoactive drugs resulting in impaired hepatic and/or renal function. To investigate the effect of extracorporeal membrane oxygenation (ECMO) in donor management, ECMO was used to provide support for DBD donors with circulatory and/or respiratory failure from 2013 to 2015. A retrospective cohort study between circulatory non-stable DBD with vasoactive drugs (DBD-drug) and circulatory non-stable DBD with ECMO (DBD-ECMO) was designed to compare the transplant outcomes. A total of 19 brain death donors were supported by ECMO. The incidence rate of post-transplant liver primary non-function (PNF) was 10% (two of 20) in DBD-drug group and zero in DBD-ECMO group. Kidney function indicators, including creatinine clearance and urine production, were significantly better in DBD-ECMO group, as well as the kidney delayed graft function (DGF) rate was found to be decreased by the use of ECMO in our study. Donation success rate increased steadily from 47.8% in 2011 to 84.6% in 2014 after the ECMO intervention. The use of ECMO in assisting circulatory and respiratory function of DBD can reduce liver and kidney injury from vasoactive drugs, thereby improving organ quality and reducing the organ discard rates.

  6. MOIDSS?- Mobile Online Intelligent Decision Support System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — GRID has had a successfully completed Phase I 'Mobile Online Intelligent Decision Support System' (MOIDSS). The system developed into a total solution that supports...

  7. Radiation and risk of circulatory diseases in the German uranium miners cohort study

    Energy Technology Data Exchange (ETDEWEB)

    Kreuzer, M.; Kreisheimer, M.; Kandel, M.; Tschense, A.; Grosche, B. [Federal Office for Radiation Protection, Neuherberg (Germany)

    2006-07-01

    cohort members (n=50,707) were ever exposed to radiation. Among the exposed, the mean cumulative exposure to radon was 280 W.L.M. (maximum 3,224 W.L.M.), to long-lived radionuclides 4 kBq h/m{sup 3} (maximum 132 kBq h/m3) and to external gamma radiation 47 mSv (maximum 909 mSv). No increase in risk of circulatory diseases with increasing cumulative exposure to radon (E.R.R. per 100 W.L.M. = 0,00067; 95% confidence limit (CI): -0,0044 to 0,0058), to external gamma radiation (E.R.R. per Sv -0,18, 95% CI: -0,55 to 0,19) and to long-lived radionuclides (E.R.R per kBq h/m{sup 3} -0.0018, 95% CI: - 0.005 to 0.0015) was observed. This was also true for the sub -group of heart diseases and strokes. In addition, no association was found when exposures were categorized and a parameter free model was applied. Conclusion: These results do not support an association between circulatory diseases and exposures to radiation as they typically had occurred among uranium miners. A limitation in interpretation of these data concerns that potential confounder such as smoking, overweight, alcohol, blood pressure and others could not be considered. Literature: Mc Gale, P. and Darby, S.C. Low doses of ionizing Radiation and circulatory diseases: A systematic review of the published epidemiological evidence. Radiat Res 2005; 163: 247-257. (authors)

  8. Artificial and bioartificial support systems for liver failure

    DEFF Research Database (Denmark)

    Liu, Jianping; Kjaergard, Lise Lotte; Als-Nielsen, Bodil;

    2002-01-01

    Liver support systems may bridge patients to liver transplantation or recovery from liver failure. This review is to evaluate the beneficial and harmful effects of artificial and bioartificial support systems for acute and acute-on-chronic liver failure.......Liver support systems may bridge patients to liver transplantation or recovery from liver failure. This review is to evaluate the beneficial and harmful effects of artificial and bioartificial support systems for acute and acute-on-chronic liver failure....

  9. Support System for Mental Health Professionals

    Directory of Open Access Journals (Sweden)

    Ajit Dandekar

    2015-01-01

    Full Text Available This paper talks of support systems for mental health professionals wherein the Bombay Psychiatric Society (BPS should devote some meetings exclusively to problems pertaining to the profession, e.g., long and odd working hours leading to potentially hazardous practice schedules, unhealthy competitive attitudes and culture. A crash course in self-defence against potentially psychotic patients and drug addicts is advocated as also awareness of the potential hazards in dealing with the litigious paranoid patients, erotomaniacs and some of the difficult hysterical patients. Potential medicolegal problems arise in treating an uncooperative patient without his knowledge and consent on an outpatient department basis, admitting such an uncooperative patient to a nursing home or a hospital, administering electroconvulsive therapies, maintaining detailed clinical records of patients, and legal issues involving smaller psychiatric private nursing homes. This paper stresses on the use of Yoga as a recognised psycho-physiological therapy. Furthermore, it suggests on the need for BPS, as a professional body, to have a cell to guide and help aspiring young professionals in setting up private practice. It points out the need to evolve some concrete programmes that in the long run should help alleviate stresses and strains and promote positive comprehensive health amongst mental health professionals.

  10. 30 CFR 75.817 - Cable handling and support systems.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Cable handling and support systems. 75.817... High-Voltage Longwalls § 75.817 Cable handling and support systems. Longwall mining equipment must be provided with cable-handling and support systems that are constructed, installed and maintained to...

  11. Description, validation, and modification of the Guyton model for space-flight applications. Part A. Guyton model of circulatory, fluid and electrolyte control. Part B. Modification of the Guyton model for circulatory, fluid and electrolyte control

    Science.gov (United States)

    Leonard, J. I.

    1985-01-01

    The mathematical model that has been a cornerstone for the systems analysis of space-flight physiological studies is the Guyton model describing circulatory, fluid and electrolyte regulation. The model and the modifications that are made to permit simulation and analysis of the stress of weightlessness are described.

  12. A Computuerized Operator Support System Prototype

    Energy Technology Data Exchange (ETDEWEB)

    Ken Thomas; Ronald Boring; Roger Lew; Tom Ulrich; Richard Villim

    2013-08-01

    A report was published by the Idaho National Laboratory in September of 2012, entitled Design to Achieve Fault Tolerance and Resilience, which described the benefits of automating operator actions for transients. The report identified situations in which providing additional automation in lieu of operator actions would be advantageous. It recognized that managing certain plant upsets is sometimes limited by the operator’s ability to quickly diagnose the fault and to take the needed actions in the time available. Undoubtedly, technology is underutilized in the nuclear power industry for operator assistance during plant faults and operating transients. In contrast, other industry sectors have amply demonstrated that various forms of operator advisory systems can enhance operator performance while maintaining the role and responsibility of the operator as the independent and ultimate decision-maker. A computerized operator support system (COSS) is proposed for use in nuclear power plants to assist control room operators in addressing time-critical plant upsets. A COSS is a collection of technologies to assist operators in monitoring overall plant performance and making timely, informed decisions on appropriate control actions for the projected plant condition. The COSS does not supplant the role of the operator, but rather provides rapid assessments, computations, and recommendations to reduce workload and augment operator judgment and decision-making during fast-moving, complex events. This project proposes a general model for a control room COSS that addresses a sequence of general tasks required to manage any plant upset: detection, validation, diagnosis, recommendation, monitoring, and recovery. The model serves as a framework for assembling a set of technologies that can be interrelated to assist with each of these tasks. A prototype COSS has been developed in order to demonstrate the concept and provide a test bed for further research. The prototype is based

  13. A Computuerized Operator Support System Prototype

    Energy Technology Data Exchange (ETDEWEB)

    Ken Thomas; Ronald Boring; Roger Lew; Tom Ulrich; Richard Villim

    2013-11-01

    A report was published by the Idaho National Laboratory in September of 2012, entitled Design to Achieve Fault Tolerance and Resilience, which described the benefits of automating operator actions for transients. The report identified situations in which providing additional automation in lieu of operator actions would be advantageous. It recognized that managing certain plant upsets is sometimes limited by the operator’s ability to quickly diagnose the fault and to take the needed actions in the time available. Undoubtedly, technology is underutilized in the nuclear power industry for operator assistance during plant faults and operating transients. In contrast, other industry sectors have amply demonstrated that various forms of operator advisory systems can enhance operator performance while maintaining the role and responsibility of the operator as the independent and ultimate decision-maker. A computerized operator support system (COSS) is proposed for use in nuclear power plants to assist control room operators in addressing time-critical plant upsets. A COSS is a collection of technologies to assist operators in monitoring overall plant performance and making timely, informed decisions on appropriate control actions for the projected plant condition. The COSS does not supplant the role of the operator, but rather provides rapid assessments, computations, and recommendations to reduce workload and augment operator judgment and decision-making during fast-moving, complex events. This project proposes a general model for a control room COSS that addresses a sequence of general tasks required to manage any plant upset: detection, validation, diagnosis, recommendation, monitoring, and recovery. The model serves as a framework for assembling a set of technologies that can be interrelated to assist with each of these tasks. A prototype COSS has been developed in order to demonstrate the concept and provide a test bed for further research. The prototype is based

  14. Environmental Control and Life Support System, Oxygen Generation System

    Science.gov (United States)

    2000-01-01

    The Environmental Control and Life Support System (ECLSS) Group of the Flight Projects Directorate at the Marshall Space Flight Center (MSFC) in Huntsville, Alabama, is responsible for designing and building the life support systems that will provide the crew of the International Space Station (ISS) a comfortable environment in which to live and work. This is a close-up view of ECLSS Oxygen Generation System (OGS) rack. The ECLSS Group at the MSFC oversees the development of the OGS, which produces oxygen for breathing air for the crew and laboratory animals, as well as for replacing oxygen lost due to experiment use, airlock depressurization, module leakage, and carbon dioxide venting. The OGS consists primarily of the Oxygen Generator Assembly (OGA), provided by the prime contractor, the Hamilton Sundstrand Space Systems, International (HSSSI) in Windsor Locks, Cornecticut and a Power Supply Module (PSM), supplied by the MSFC. The OGA is comprised of a cell stack that electrolyzes (breaks apart the hydrogen and oxygen molecules) some of the clean water provided by the Water Recovery System and the separators that remove the gases from water after electrolysis. The PSM provides the high power to the OGA needed to electrolyze the water.

  15. Automated support for pharmacovigilance: a proposed system.

    Science.gov (United States)

    Bright, Roselie A; Nelson, Robert C

    2002-03-01

    Governments, manufacturers, and other entities are interested in adverse event surveillance of marketed medical products. FDA's Center for Drug Evaluation and Research redesigned the post-marketing adverse reaction surveillance process to use the advantages of new technology. As part of this effort, a 'Pharmacovigilance Working Group' designed a new strategy for the review and analyses of adverse event reports received by FDA. It created requirements which divided signal detection into five tiers: (1) Single 'urgent' reports would be sent to reviewers' workstations nightly for immediate attention. Reviewers would be able to customize definitions of 'urgent' (events that should not wait for aggregate review). (2) Single urgent reports would be placed in a context matrix containing historical counts of similar events to aid in initial interpretation. (3) In this first level of aggregate review, graphical displays would highlight patterns within all the reports, both urgent and non-urgent, and (4) periodic drug-specific tabled-based reports would display the newly received reports across a pre-defined variety of displays. These four tiers would produce passive and criteria-based results which would be presented to safety reviewers' electronic workstations. (5) Active query capabilities (routine, such as age, sex, and year distributions, as well as ad hoc) would be available for exploring alerted issues. The historical database would be migrated into the new format. All historical and new reaction data would be coded with the new MedDRA (Medical Dictionary for Regulatory Activities) scheme. The strategy was to design a full data capture system which effectively exploits current computing advances and technical performance to automate many aspects of initial adverse event review, supporting more efficient and effective clinical assessment of safety signals.

  16. Trends in death from circulatory diseases in Brazil between 1979 and 1996

    Directory of Open Access Journals (Sweden)

    Mansur Antonio de Padua

    2001-01-01

    Full Text Available OBJECTIVE: To analyze the trends in mortality due to circulatory diseases in men and women aged > or = 30 years in Brazil from 1979 to 1996. METHODS: We analyzed population count data obtained from the IBGE Foundation and mortality data obtained from the System of Information on Mortality of the DATASUS of the Ministry of Health. RESULTS: Circulatory diseases, ischemic heart disease, and cerebrovascular disease were the major causes of death in men and women in Brazil. The standardized age coefficient for circulatory disease in men aged > or = 30 years ranged from 620 to 506 deaths/100,000 inhabitants and in women from 483 to 383 deaths/100,000 inhabitants for the years 1979 and 1996, respectively. In men, the mean coefficient for the period was 586.25 deaths with a significant trend towards a decrease (P<0.001 and a decline of 8.25 deaths/year. In women, the mean coefficient for the period was 439.58 deaths, a significant trend towards a decrease (P<0.001 and a rate of decline of 7.53 deaths/year. The same significant trend towards a decrease in death (P<0.001 was observed for ischemic heart disease and cerebrovascular disease. Risk of death from these causes was always higher for men of any age group (P<0.001. Cerebrovascular disease was the primary cause of death in women. CONCLUSION: Although circulatory diseases have been the major cause of mortality in men and women in the Brazilian population, with a greater participation by cerebrovascular diseases, a trend towards a decrease in the risk of death from these causes is being observed.

  17. Using systems thinking to support clinical system transformation.

    Science.gov (United States)

    Best, Allan; Berland, Alex; Herbert, Carol; Bitz, Jennifer; van Dijk, Marlies W; Krause, Christina; Cochrane, Douglas; Noel, Kevin; Marsden, Julian; McKeown, Shari; Millar, John

    2016-05-16

    Purpose - The British Columbia Ministry of Health's Clinical Care Management initiative was used as a case study to better understand large-scale change (LSC) within BC's health system. Using a complex system framework, the purpose of this paper is to examine mechanisms that enable and constrain the implementation of clinical guidelines across various clinical settings. Design/methodology/approach - Researchers applied a general model of complex adaptive systems plus two specific conceptual frameworks (realist evaluation and system dynamics mapping) to define and study enablers and constraints. Focus group sessions and interviews with clinicians, executives, managers and board members were validated through an online survey. Findings - The functional themes for managing large-scale clinical change included: creating a context to prepare clinicians for health system transformation initiatives; promoting shared clinical leadership; strengthening knowledge management, strategic communications and opportunities for networking; and clearing pathways through the complexity of a multilevel, dynamic system. Research limitations/implications - The action research methodology was designed to guide continuing improvement of implementation. A sample of initiatives was selected; it was not intended to compare and contrast facilitators and barriers across all initiatives and regions. Similarly, evaluating the results or process of guideline implementation was outside the scope; the methods were designed to enable conversations at multiple levels - policy, management and practice - about how to improve implementation. The study is best seen as a case study of LSC, offering a possible model for replication by others and a tool to shape further dialogue. Practical implications - Recommended action-oriented strategies included engaging local champions; supporting local adaptation for implementation of clinical guidelines; strengthening local teams to guide implementation; reducing

  18. Prototyping a Rangeland Decision Support System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This proposal is submitted under the Innovative Tools and Techniques Supporting the Practical Uses of Earth Science Observations topic. We seek to create a prototype...

  19. A Geospatial Decision Support System Toolkit Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to design a working prototype Geospatial Decision Support Toolkit (GeoKit) that will enable scientists, agencies, and stakeholders to configure and deploy...

  20. Visitor schedule management system- an intelligent decision support system

    CERN Document Server

    Nidhra, Srinivas; Ethiraj, Vinay Sudha

    2012-01-01

    Travelling salesman problem is a problem which is of high interest for researchers, industry professionals, and academicians. Visitor or salesman used to face lot of problems with respect to scheduling based on meeting top ranked clients. Even excel sheet made the work tedious. So these flaws propelled us to design an intelligent decision support system. This paper reports the problem definition we tried to address and possible solution to this problem. We even explained the project design and implementation of our visitor schedule management system.. Our system made a major contribution in terms of valuable resources such as time and satisfying high ranked clients efficiently. We used optimization via mathematical programming to solve these issues.

  1. Sttudy on intelligent spatial decision support system of agriculture

    Institute of Scientific and Technical Information of China (English)

    ZHANG Rong-mei; SUN Jie-li

    2006-01-01

    This paper studies how to apply GIS, ES, and Data mining and WEB technologies in agriculture Decision Support System, with the researching background of Hebei expert system for farming soil variable rate fertilization. A model of agriculture intelligent spatial decision support system is built and the key technologies to implement this system are described in details.

  2. Safety implications of electronic driving support systems : an orientation.

    NARCIS (Netherlands)

    Gundy, C.M. Steyvers, F.J.J.M. & Kaptein, N.A.

    1995-01-01

    This report focuses on traffic safety aspects of driving support systems. The report consists of two parts. First of all, the report discusses a number of topics, relevant for the implementation and evaluation of driving support systems. These topics include: (1) safety research into driving support

  3. Management Decision Support Systems: From Theory to Practice.

    Science.gov (United States)

    Wong, Simon C. H.

    1995-01-01

    A decision support system integrates individuals' intellectual resources with computer capabilities to improve decision-making quality. This paper presents the theoretical aspects of decision making and decision support and shows how the theories can be applied in developing an operational management decision-making support system for room booking…

  4. A problem solving framework for group decision support system

    Institute of Scientific and Technical Information of China (English)

    陈晓红; 周艳菊; 胡东滨

    2002-01-01

    A new problem solving framework for group decision support system using layer model approach is proposed. This kind of framework includes four basic layers, namely, application layer, task layer, logical layer and physical layer. Based on indicating the respective meanings of those layers a task skeleton of group decision support system and a logical structure of group decision support system generator are put forward and discussed in detail. The framework provides theoretical guidance for developing group decision support system to lower systematic development complexity and support reuse of software.

  5. Space Launch System Vibration Analysis Support

    Science.gov (United States)

    Johnson, Katie

    2016-01-01

    The ultimate goal for my efforts during this internship was to help prepare for the Space Launch System (SLS) integrated modal test (IMT) with Rodney Rocha. In 2018, the Structural Engineering Loads and Dynamics Team will have 10 days to perform the IMT on the SLS Integrated Launch Vehicle. After that 10 day period, we will have about two months to analyze the test data and determine whether the integrated vehicle modes/frequencies are adequate for launching the vehicle. Because of the time constraints, NASA must have newly developed post-test analysis methods proven well and with technical confidence before testing. NASA civil servants along with help from rotational interns are working with novel techniques developed and applied external to Johnson Space Center (JSC) to uncover issues in applying this technique to much larger scales than ever before. We intend to use modal decoupling methods to separate the entangled vibrations coming from the SLS and its support structure during the IMT. This new approach is still under development. The primary goal of my internship was to learn the basics of structural dynamics and physical vibrations. I was able to accomplish this by working on two experimental test set ups, the Simple Beam and TAURUS-T, and by doing some light analytical and post-processing work. Within the Simple Beam project, my role involves changing the data acquisition system, reconfiguration of the test set up, transducer calibration, data collection, data file recovery, and post-processing analysis. Within the TAURUS-T project, my duties included cataloging and removing the 30+ triaxial accelerometers, coordinating the removal of the structure from the current rolling cart to a sturdy billet for further testing, preparing the accelerometers for remounting, accurately calibrating, mounting, and mapping of all accelerometer channels, and some testing. Hammer and shaker tests will be performed to easily visualize mode shapes at low frequencies. Short

  6. Desicion Support System For Natural Hazards

    Science.gov (United States)

    Vyazilov, E.

    2009-04-01

    recommendations should be reasonable. To resolve the above problems or to make them less significant it is necessary to develop decision support systems (DSS). DMs need not tables with initial data, analytical, forecasting and climatic information, but messages containing warnings on critical value accidence, information on probability of hazards, information on potential losses, and information on hazardous impacts and recommendations on decision making. DSS can do the following: take into account impacts on specific points and on the total area under consideration; allow for the effects of the environment on economic entities (objects) in any geographical region to be analyzed; distinguish impacts and changes caused both by different phenomena and by their combination; signal when objects are or can be in adverse environmental conditions, e.g. in the area affected by fog, storm, tropical cyclone or in the area where the probability of hazardous ice events is very high, etc. The main component of DSS is a knowledge base based on the following concept: if we know environmental conditions it is possible to predict potential impacts on the economy; if we know impacts it is possible to give a set of recommendations on how to prevent (reduce) losses or how to use natural resources most efficiently. Decision making criteria are safety of people and property, reduction of losses, increase of profit, materials saving, etc. Knowledge base is a set of rules formulated in a formalized way using if, that, else. If "Water level in S.-Petersburg >150 cm" that "To give out warning information "Hazards for building on coastal river Neva is possible" and recommendations "The valuable goods carry out in second floor" else "To switch another rule". To have a knowledge base in place it is necessary to: develop tools of identifying and getting knowledge from experts; arrange the information flow from available information systems (operational data, analyses, forecasts, climatic information) through

  7. Electrical Properties of Carbon Fiber Support Systems

    CERN Document Server

    Cooper, W; Demarteau, M; Fast, J; Hanagaki, K; Johnson, M; Kuykendall, W; Lubatti, H; Matulik, M; Nomerotski, A; Quinn, B; Wang, J

    2005-01-01

    Carbon fiber support structures have become common elements of detector designs for high energy physics experiments. Carbon fiber has many mechanical advantages but it is also characterized by high conductivity, particularly at high frequency, with associated design issues. This paper discusses the elements required for sound electrical performance of silicon detectors employing carbon fiber support elements. Tests on carbon fiber structures are presented indicating that carbon fiber must be regarded as a conductor for the frequency region of 10 to 100 MHz. The general principles of grounding configurations involving carbon fiber structures will be discussed. To illustrate the design requirements, measurements performed with a silicon detector on a carbon fiber support structure at small radius are presented. A grounding scheme employing copper-kapton mesh circuits is described and shown to provide adequate and robust detector performance.

  8. Using Word Processing to Implement an Effective Administrative Support System

    Science.gov (United States)

    Taylor, Wendy

    1978-01-01

    Describes the steps taken to reorganize the Administrative Support System of Houston Independent School District, to make it more efficient. A more flexible multi-function support team replaced the traditional private secretaries arrangement. (GA)

  9. Infrastructure Support for Collaborative Pervasive Computing Systems

    DEFF Research Database (Denmark)

    Vestergaard Mogensen, Martin

    -blown implementation of the proposed concepts. Finally, we contribute to the Distribution Mechanisms researching epidemic protocols or gossiping as distribution protocols for pervasive environments. Presenting these four contributions to the area of infrastructure support for CPCS, this research contributes to an area...

  10. SCOPE : an intelligent maintenance system for supporting crew operations

    NARCIS (Netherlands)

    Bos, A.; Breebaart, L.; Neerincx, M.A.; Wolff, M.

    2004-01-01

    This paper describes an intelligent maintenance system for Supporting Crew OPErations (SCOPE). SCOPE supports the astronauts onboard the ISS and helps them to maximize the availability of complex payload systems. SCOPE detects system failures, guides the isolation of the root causes of failure, and

  11. 46 CFR 56.50-110 - Diving support systems.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Diving support systems. 56.50-110 Section 56.50-110... APPURTENANCES Design Requirements Pertaining to Specific Systems § 56.50-110 Diving support systems. (a) In addition to the requirements of this part, piping for diving installations which is permanently...

  12. 2013 Robotics Science & Systems Conference Travel Support

    Science.gov (United States)

    2015-01-21

    Research Office P.O. Box 12211 Research Triangle Park, NC 27709-2211 robotics conference, travel support REPORT DOCUMENTATION PAGE 11. SPONSOR...NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. University of Washington 4333 Brooklyn AVE NE Box 359472 Seattle, WA 98195 -9472 31-May-2014 ABSTRACT...travel of invited speakers and students from the U.S. (a) Papers published in peer-reviewed journals (N/A for none) Enter List of papers submitted or

  13. Japanese Learning Support Systems: Hinoki Project Report

    Directory of Open Access Journals (Sweden)

    Bor HODOŠČEK

    2012-12-01

    Full Text Available In this report, we introduce the Hinoki project, which set out to develop web-based Computer-Assisted Language Learning (CALL systems for Japanese language learners more than a decade ago. Utilizing Natural Language Processing technologies and other linguistic resources, the project has come to encompass three systems, two corpora and many other resources. Beginning with the reading assistance system Asunaro, we describe the construction of Asunaro's multilingual dictionary and it's dependency grammar-based approach to reading assistance. The second system, Natsume, is a writing assistance system that uses large-scale corpora to provide an easy to use collocation search feature that is interesting for it's inclusion of the concept of genre. The final system, Nutmeg, is an extension of Natsume and the Natane learner corpus. It provides automatic correction of learners errors in compositions by using Natsume for its large corpus and genre-aware collocation data and Natane for its data on learner errors.

  14. Software Architecture Patterns for System Administration Support

    NARCIS (Netherlands)

    Bijvank, Ronald; Wiersema, Wiebe; Köppe, Christian

    2013-01-01

    Many quality aspects of software systems are addressed in the existing literature on software architecture patterns. But the aspect of system administration seems to be a bit overlooked, even though it is an important aspect too. In this work we present three software architecture patterns that, whe

  15. Control Systems Cyber Security Standards Support Activities

    Energy Technology Data Exchange (ETDEWEB)

    Robert Evans

    2009-01-01

    The Department of Homeland Security’s Control Systems Security Program (CSSP) is working with industry to secure critical infrastructure sectors from cyber intrusions that could compromise control systems. This document describes CSSP’s current activities with industry organizations in developing cyber security standards for control systems. In addition, it summarizes the standards work being conducted by organizations within the sector and provides a brief listing of sector meetings and conferences that might be of interest for each sector. Control systems cyber security standards are part of a rapidly changing environment. The participation of CSSP in the development effort for these standards has provided consistency in the technical content of the standards while ensuring that information developed by CSSP is included.

  16. E3 Travel & Mission Support System

    Data.gov (United States)

    US Agency for International Development — ETRAMS is a travel data collection system developed by the CKM team in E3 that collects information on both the basic details of an employee's trips (destination,...

  17. Long term perfusion system supporting adipogenesis.

    Science.gov (United States)

    Abbott, Rosalyn D; Raja, Waseem K; Wang, Rebecca Y; Stinson, Jordan A; Glettig, Dean L; Burke, Kelly A; Kaplan, David L

    2015-08-01

    Adipose tissue engineered models are needed to enhance our understanding of disease mechanisms and for soft tissue regenerative strategies. Perfusion systems generate more physiologically relevant and sustainable adipose tissue models, however adipocytes have unique properties that make culturing them in a perfusion environment challenging. In this paper we describe the methods involved in the development of two perfusion culture systems (2D and 3D) to test their applicability for long term in vitro adipogenic cultures. It was hypothesized that a silk protein biomaterial scaffold would provide a 3D framework, in combination with perfusion flow, to generate a more physiologically relevant sustainable adipose tissue engineered model than 2D cell culture. Consistent with other studies evaluating 2D and 3D culture systems for adipogenesis we found that both systems successfully model adipogenesis, however 3D culture systems were more robust, providing the mechanical structure required to contain the large, fragile adipocytes that were lost in 2D perfused culture systems. 3D perfusion also stimulated greater lipogenesis and lipolysis and resulted in decreased secretion of LDH compared to 2D perfusion. Regardless of culture configuration (2D or 3D) greater glycerol was secreted with the increased nutritional supply provided by perfusion of fresh media. These results are promising for adipose tissue engineering applications including long term cultures for studying disease mechanisms and regenerative approaches, where both acute (days to weeks) and chronic (weeks to months) cultivation are critical for useful insight.

  18. Donation after cardio-circulatory death liver transplantation

    Institute of Scientific and Technical Information of China (English)

    Hieu Le Dinh; Arnaud de Roover; Abdour Kaba; Séverine Lauwick; Jean Joris; Jean Delwaide; Pierre Honoré

    2012-01-01

    The renewed interest in donation after cardio-circulatory death (DCD) started in the 1990s following the limited success of the transplant community to expand the donation after brain-death (DBD) organ supply and following the request of potential DCD families.Since then,DCD organ procurement and transplantation activities have rapidly expanded,particularly for nonvital organs,like kidneys.In liver transplantation (LT),DCD donors are a valuable organ source that helps to decrease the mortality rate on the waiting lists and to increase the availability of organs for transplantation despite a higher risk of early graft dysfunction,more frequent vascular and ischemia-type biliary lesions,higher rates of re-listing and re-transplantation and lower graft survival,which are obviously due to the inevitable warm ischemia occurring during the declaration of death and organ retrieval process.Experimental strategies intervening in both donors and recipients at different phases of the transplantation process have focused on the attenuation of ischemia-reperfusion injury and already gained encouraging results,and some of them have found their way from pre-clinical success into clinical reality.The future of DCD-LT is promising.Concerted efforts should concentrate on the identification of suitable donors (probably Maastricht category Ⅲ DCD donors),better donor and recipient matching (high risk donors to low risk recipients),use of advanced organ preservation techniques (oxygenated hypothermic machine perfusion,normothermic machine perfusion,venous systemic oxygen persufflation),and pharmacological modulation (probably a multi-factorial biologic modulation strategy) so that DCD liver allografts could be safely utilized and attain equivalent results as DBD-LT.

  19. A support architecture for reliable distributed computing systems

    Science.gov (United States)

    Dasgupta, Partha; Leblanc, Richard J., Jr.

    1988-01-01

    The Clouds project is well underway to its goal of building a unified distributed operating system supporting the object model. The operating system design uses the object concept of structuring software at all levels of the system. The basic operating system was developed and work is under progress to build a usable system.

  20. System Support for Managing Invalid Bindings

    CERN Document Server

    Das, Lachhman; Shah, Azhar; Khoumbati, Khalil; 10.5121/iju.2011.2303

    2011-01-01

    Context-aware adaptation is a central aspect of pervasive computing applications, enabling them to adapt and perform tasks based on contextual information. One of the aspects of context-aware adaptation is reconfiguration in which bindings are created between application component and remote services in order to realize new behaviour in response to contextual information. Various research efforts provide reconfiguration support and allow the development of adaptive context-aware applications from high-level specifications, but don't consider failure conditions that might arise during execution of such applications, making bindings between application and remote services invalid. To this end, we propose and implement our design approach to reconfiguration to manage invalid bindings. The development and modification of adaptive context-aware applications is a complex task, and an issue of an invalidity of bindings further complicates development efforts. To reduce the development efforts, our approach provides ...

  1. System Engineering and Evolution Decision Support

    Science.gov (United States)

    2007-11-02

    Theoretical Computer Science, Elsivier Science, 1999. 16. Luqi, "Engineering Automation for Computer Based Systems", Electronic Notes in Theoretical Computer...Science, Elsivier Science, 1999. 17. M. Shing, Luqi, V. Berzins, M. Saluto and J. Williams, "Architectural Re-engineering of Janus using Object Modeling

  2. Agile Information System Supporting Virtual Enterprise Operation

    Institute of Scientific and Technical Information of China (English)

    许青松; 陶丹; 范玉顺

    2001-01-01

    Dynamic collaboration is a relationship of companies working together for mutual benefit to bring acomplementary set of competencies to gain a market opportunity. A mechanism to manage and controlinformation flow among collaborating partners is described in this paper. Analysis of the virtual informationsystem requirements was used to develop an agile manufacturing information system (AMIS) to create, sustainand dissolve a virtual enterprise.``

  3. 14 CFR 417.307 - Support systems.

    Science.gov (United States)

    2010-01-01

    ... security provisions for controlling access to all controls and other related hardware. These security... include a launch vehicle tracking system that provides launch vehicle position and status data to the flight safety crew from the first data loss flight time until the planned safe flight state for...

  4. System safety activities supporting an aero-space plane ground support technology

    Science.gov (United States)

    Mattern, Steven F.

    1992-01-01

    An overview is presented of the specific system safety activities required to support the ground support technology program associated with the design of an aerospace plane. Safe zones must be assessed to ensure that explosive safety requirements are attained to protect the vehicle, personnel, and support and operational facilities. Attention is given to the specific and unique design requirements connected with the utilization of cryogenic fuels as they apply to the design and development of an aerospace plane.

  5. Specification Language NUJSL Based on JSP and Its Supporting System

    Institute of Scientific and Technical Information of China (English)

    徐永森; 何飚

    1992-01-01

    is paper presents the specification languange NUJSL and its supporting system.NUJSL is a modular specification language based on Jackson Program Design Method(JSP).With the module construction,it is convenient to use NUJSL to write larger specifications.The supporting system supports the incremental development of software specification in NUJSL,and implements the transformation both from specification to software procedural description in Jackson Schematic Logic(pseudo code)and from procedural description to PASCAL program.

  6. Fault Detection for Shipboard Monitoring and Decision Support Systems

    DEFF Research Database (Denmark)

    Lajic, Zoran; Nielsen, Ulrik Dam

    2009-01-01

    In this paper a basic idea of a fault-tolerant monitoring and decision support system will be explained. Fault detection is an important part of the fault-tolerant design for in-service monitoring and decision support systems for ships. In the paper, a virtual example of fault detection will be p...

  7. A Study on Simulation of Aircraft Maintenance and Support System

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Maintenance and support are basic elements to realize the effectiveness of aircraft. For basic analysis of the characteristics of an aircraft maintenance and support system, a simulation method is presented in this paper, and the structure and realization ofthe simulation system is discussed.

  8. Rhode Island Model Evaluation & Support System: Teacher. Edition III

    Science.gov (United States)

    Rhode Island Department of Education, 2015

    2015-01-01

    Rhode Island educators believe that implementing a fair, accurate, and meaningful educator evaluation and support system will help improve teaching and learning. The primary purpose of the Rhode Island Model Teacher Evaluation and Support System (Rhode Island Model) is to help all teachers improve. Through the Model, the goal is to help create a…

  9. Rhode Island Model Evaluation & Support System: Building Administrator. Edition III

    Science.gov (United States)

    Rhode Island Department of Education, 2015

    2015-01-01

    Rhode Island educators believe that implementing a fair, accurate, and meaningful educator evaluation and support system will help improve teaching, learning, and school leadership. The primary purpose of the Rhode Island Model Building Administrator Evaluation and Support System (Rhode Island Model) is to help all building administrators improve.…

  10. Fault-Tolerant Onboard Monitoring and Decision Support Systems

    DEFF Research Database (Denmark)

    Lajic, Zoran

    The purpose of this research project is to improve current onboard decision support systems. Special focus is on the onboard prediction of the instantaneous sea state. In this project a new approach to increasing the overall reliability of a monitoring and decision support system has been...

  11. Artificial and bioartificial support systems for liver failure

    DEFF Research Database (Denmark)

    Liu, J P; Gluud, L L; Als-Nielsen, B;

    2004-01-01

    Artificial and bioartificial liver support systems may 'bridge' patients with acute or acute-on-chronic liver failure to liver transplantation or recovery.......Artificial and bioartificial liver support systems may 'bridge' patients with acute or acute-on-chronic liver failure to liver transplantation or recovery....

  12. Mock Circulatory Loop Compliance Chamber Employing a Novel Real-Time Control Process.

    Science.gov (United States)

    Taylor, Charles E; Miller, Gerald E

    2012-12-01

    The use of compliance chambers in mock circulatory loop construction is the predominant means of simulating arterial compliance. Utilizing mock circulatory loops as bench test methods for cardiac assist technologies necessitates that they must be capable of reproducing the circulatory conditions that would exist physiologically. Of particular interest is the ability to determine instantaneous compliance of the system, and the ability to change the compliance in real-time. This capability enables continuous battery testing of conditions without stopping the flow to change the compliance chamber settings, and the simulation of dynamic changes in arterial compliance. The method tested involves the use of a compliance chamber utilizing a circular natural latex rubber membrane separating the fluid and air portions of the device. Change in system compliance is affected by the airspace pressure, which creates more reaction force at the membrane to the fluid pressure. A pressure sensor in the fluid portion of the chamber and a displacement sensor monitoring membrane center deflection allow for real-time inputs to the control algorithm. A predefined numerical model correlates the displacement sensor data to the volume displacement of the membrane. The control algorithm involves a tuned π loop maintaining the volume distention of the membrane via regulation of the air space pressure. The proportional integral (PI) controller tuning was achieved by creating a computational model of the compliance chamber using Simulink™ Simscape(®) toolboxes. These toolboxes were used to construct a model of the hydraulic, mechanical, and pneumatic elements in the physical design. Parameter Estimation™ tools and Design Optimization™ methods were employed to determine unknown physical parameters in the system, and tune the process controller used to maintain the compliance setting. It was found that the resulting control architecture was capable of maintaining compliance along a

  13. Japanese Learning Support Systems: Hinoki Project Report

    Directory of Open Access Journals (Sweden)

    HODOŠČEK, Bor

    2012-12-01

    Full Text Available In this report, we introduce the Hinoki project, which set out to develop web-based Computer-Assisted Language Learning (CALL systems for Japanese language learners more than a decade ago. Utilizing Natural Language Processing technologies and other linguistic resources, the project has come to encompass three systems, two corpora and many other resources. Beginning with the reading assistance system Asunaro, we describe the construction of Asunaro's multilingual dictionary and it's dependency grammar-based approach to reading assistance. The second system, Natsume, is a writing assistance system that uses large-scale corpora to provide an easy to use collocation search feature that is interesting for it's inclusion of the concept of genre. The final system, Nutmeg, is an extension of Natsume and the Natane learner corpus. It provides automatic correction of learners errors in compositions by using Natsume for its large corpus and genre-aware collocation data and Natane for its data on learner errors.-----V poročilu predstavljamo projekt Hinoki, ki je bil zastavljen pred več kot desetimi leti za izdelavo spletnih sistemov za računalniško podprto učenje japonščine kot tujega jezika. Z uporabo jezikovnih tehnologij in drugih jezikovnih virov so bili v okviru projekta razviti trije sistemi, dva korpusa in veliko drugih virov. V nadaljevanju predstavljamo sistem Asunaro za podporo branju, izgradnjo njegovega večjezičnega slovarja in pristop k podpori branju, ki sloni na odvisnostni slovnici; sistem za podporo pisanju Natsume s preprostim vmesnikom za iskanje žanrsko določenih kolokacij v obsežnih korpusih; ter sistem Nutmeg za samodejno popravljanje napak. Nutmeg je nadgradnja sistema Natsume in učnega korpusa Natane, ponuja samodejno popravljanje napak med samim pisanjem z uporabo žanrsko določenih kolokacijskih informacij iz obsežnih korpusov preko sistema Natsume in informacij o napakah piscev, ki se učijo japonščine kot tujega

  14. Reliability Growth in Space Life Support Systems

    Science.gov (United States)

    Jones, Harry W.

    2014-01-01

    A hardware system's failure rate often increases over time due to wear and aging, but not always. Some systems instead show reliability growth, a decreasing failure rate with time, due to effective failure analysis and remedial hardware upgrades. Reliability grows when failure causes are removed by improved design. A mathematical reliability growth model allows the reliability growth rate to be computed from the failure data. The space shuttle was extensively maintained, refurbished, and upgraded after each flight and it experienced significant reliability growth during its operational life. In contrast, the International Space Station (ISS) is much more difficult to maintain and upgrade and its failure rate has been constant over time. The ISS Carbon Dioxide Removal Assembly (CDRA) reliability has slightly decreased. Failures on ISS and with the ISS CDRA continue to be a challenge.

  15. Development of a group support system to support collaborative works in value management workshops

    Institute of Scientific and Technical Information of China (English)

    SHEN Qi-ping; CHUNG J K H; LI Heng

    2004-01-01

    Value Management (VM) is a rigorous and systematic approach to improve the value and optimise the overall cost of a facility. It identifies opportunities to remove unnecessary costs while assuring that quality,reliability, performance, and other critical factors will meet or exceed the customers′ expectations. It has been widely used in the construction industry in a number of countries. A recent survey, however, revealed several problems that hinder the wider use of this methodology in the industry. To overcome these problems, a feasibility study has been conducted to investigate whether or not a Group Support System (GSS) can support collaborative works in VM workshops. This paper introduces the development and structure of a prototype GSS which is designed to support the collaborative works of stakeholders in VM workshops. It begins with an introduction to the conceptual GSS framework and job plan, illustrating what GSS supports can be provided to VM workshops.This is followed by a detailed description of the GSS prototype system to demonstrate how these supports can be performed as an integrated computer system. The testing of the system is also discussed. The research findings provide strong evidence in supporting the notion of using GSS to improve VM implementation. The information support of GSS has been ranked to be the most useful GSS functions and most of the practitioners interviewed are highly interested in applying GSS to support VM workshops in the future.

  16. Intelligent Information System to support decision making.

    Directory of Open Access Journals (Sweden)

    Kathrin Rodríguez Llanes

    2010-06-01

    Full Text Available Making decisions is complicated in a generalized way, the materials and humans resources of the entity we belong to depends on it, such as the fulfillment of its goals. But when the situations are complex, making decisions turns into a very difficult work, due to the great amount of aspects to consider when making the right choice. To make this efficiently the administration must to consult an important volume of information, which generally, is scattered and in any different formats. That’s why appears the need of developing software that crowd together all that information and be capable of, by using powerful search engines and process algorithms improve the good decisions making process. Considering previous explanation, a complete freeware developed product is proposed, this constitutes a generic and multi-platform solution, that using artificial intelligence techniques, specifically the cases based reasoning, gives the possibility to leaders of any institution or organism of making the right choice in any situation.With client-server architecture, this system is consumed from web as a service and it can be perfectly integrated with a management system or the geographic information system to facilitate the business process.

  17. System Administration Support/SWORDS G2

    Science.gov (United States)

    Dito, Scott Joseph

    2014-01-01

    The Soldier-Warfighter Operationally Responsive Deployer for Space (SWORDS) rocket is a dedicated small satellite launcher that will minimize danger and complexity in order to allow soldiers in the field to put payloads of up to 25kg into orbit from the field. The SWORDSG2 project is the development of a model, simulation, and ultimately a working application that will control and monitor the cryogenic fluid delivery to the SWORDS rocket for testing purposes. To accomplish this, the project is using the programming language environment Gensym G2. The environment is an all-inclusive application that allows development, testing, modeling, and finally operation of the unique application through graphical and programmatic methods. In addition, observation of the current cryogenic fluid delivery system in the Kennedy Space Center Cry Lab has allowed me to gain valuable experience of fluid systems and propelant delivery that is valuable to our team when developing amd modeling our own system.The ultimate goal of having a test-ready application to show to the heads of the project, and demonstrating G2's capabilities, by late 2014 will require hard work and intense study and understanding of not only the programming aspect but also the physical phenomena we want to model, observe, and control.

  18. Intelligent Flight Support System (IFSS): A Real-time Intelligent Decision Support Prototype Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The integration of the analysis tools with the advanced visualization capabilities in The Intelligent Flight Support System (IFSS) can provide a unique method for...

  19. APPLICATION OF OPTIMAL CONTROL THEORY TO CARDIO-CIRCULATORY ASSIST DEVICES.

    Science.gov (United States)

    The objective of the investigation is the application of, and where necessary, extension of optimal control theory to the synthesis of controllers for such cardio-circulatory assist devices. In particular, the concept of set of attainability is extended to include linear, periodic, bounded control systems and the maximum principle applied to obtain necessary and sufficient conditions for various problems. In addition to several numerical examples, the results of a large-scale hybrid simulation for a cardiovascular model and particular assist device are presented.

  20. Functionality Assessment of Ecodesign Support System

    Directory of Open Access Journals (Sweden)

    Dostatni Ewa

    2015-02-01

    Full Text Available In the paper the issue of ecological-oriented product design is addressed. The definitions that concern product design are listed and the factors that make them important for the manufacturers are indicated. The method of ecological-oriented product assessment during the design process (implemented in the 3D CAD system, drawn-up by authors, is used for the analysis. The assessment of real household appliance using the method is presented and the conclusions from the evaluation are drawn.

  1. Risk Interfaces to Support Integrated Systems Analysis and Development

    Science.gov (United States)

    Mindock, Jennifer; Lumpkins, Sarah; Shelhamer, Mark; Anton, Wilma; Havenhill, Maria

    2016-01-01

    Objectives for systems analysis capability: Develop integrated understanding of how a complex human physiological-socio-technical mission system behaves in spaceflight. Why? Support development of integrated solutions that prevent unwanted outcomes (Implementable approaches to minimize mission resources(mass, power, crew time, etc.)); Support development of tools for autonomy (need for exploration) (Assess and maintain resilience -individuals, teams, integrated system). Output of this exercise: -Representation of interfaces based on Human System Risk Board (HSRB) Risk Summary information and simple status based on Human Research Roadmap; Consolidated HSRB information applied to support communication; Point-of-Departure for HRP Element planning; Ability to track and communicate status of collaborations. 4

  2. Systems Engineering & Supportability Workshop (1st)

    Science.gov (United States)

    1998-09-01

    Solution for Legacy System Upgrades" by Michael J. Cook ....................... 131 "Data in Supportof a Programs Long Term Needs" by Carol Gutierrez ...n-~(~ (1 0 (D- -0 D r-1. - Ciw < :2 Q( 70V (n .- 0( C 0 0 - P, CID 2 . w D M ;; =0CD CL 07- h~ -- C mcn U)- CL~ ~ -(nCDef -1 CD 0 C~0 3) o oD ’-’o...0UP 282 o X. 910 0’ CID CD C Cl) @, 5-,.0 0 -0 CDM 0x (N0 (0 ~= m M C: 0 CD = (n~ CD ~W CD --12. a 0 -0 M 0 w CD _1 ( 0-* ; o 0na = 0D 0 -@ C M o o :CD

  3. Generic Opinion Mining System for Decision Support

    Directory of Open Access Journals (Sweden)

    Dr.P.G.Naik

    2016-04-01

    Full Text Available Social networking sites prove to be indispensible tools for decision making owing to the large repository of user views accumulated over a period of time. Such a real data can be exploited for various purposes such as making buying decisions, analysing the user views about new product launched by a company, product promotion campaign , impact of policy decisions made by a political party on society etc. In the current work the authors have proposed a generic model for feature based polarity determination by sentiment analysis of tweets. This model has been implemented by the seamless integration of R tool, XML, JAVA, Link Parser A practical multistep system, in place, efficiently extracts data from tweet text, pre-process the raw data to remove noise, and tags their polarity. Data used in the current study is derived from online product feature based reviews collected from tweeter tweets. Link parser version 4.1 b is employed for parsing a natural sentence which is broken into multiple tokens corresponding to noun and adjective before being stored in a persistent storage medium. The objectivity score is determined using SentiWordNet 3.0 lexical resource which is parsed using a tool implemented in Java. The linguistic hedges are taken care of using Zadeh’s proposition which modifies the final objectivity score. The objectivity score so computed, provides the necessary guidelines in influencing decisions. The authors have tested the model for product purchase decisions of two different sets of products, smart phone and laptop based on predefined set of features. The model is generic and can be applied to any set of products evaluated on a predefined set of features.

  4. Antibiotics can ameliorate circulatory complications of liver cirrhosis

    DEFF Research Database (Denmark)

    Madsen, Bjørn Stæhr; Schaffalitzky de Muckadell, Ove B

    2011-01-01

    Livercirrhosis can be complicated by a hyperdynamic circulatory syndrome. This is due to translocation of bacteria and bacterial product (bacterial DNA and endotoxins), which stimulate the splanchnic nitric oxide synthase and leads to splanchnic vasodilatation and haemodynamic derangement....... This review focuses on how broad spectrum antibiotics can ameliorate the haemodynamic consequences of bacterial translocation. It is possible that the use of broad spectrum antibiotics in the future may be used to prevent other complications of liver cirrhosis than spontaneous bacterial peritonitis...

  5. Postnatal circulatory adaptation in healthy term and preterm neonates.

    OpenAIRE

    N J Evans; Archer, L N

    1990-01-01

    Thirty seven healthy infants (18 born at full term and 19 preterm) were studied serially with cross sectional and Doppler echocardiography to compare their postnatal circulatory adaptation. Pulmonary artery pressure was assessed by its inverse relationship with the ratio of pulmonary artery time to peak velocity and right ventricular ejection time measured from Doppler waveform. Patency of the ductus arteriosus and interatrial shunting were assessed by imaging and Doppler ultrasound. The rati...

  6. Changes in respiratory and circulatory functions during sequential invasive-noninvasive mechanical ventilation

    Institute of Scientific and Technical Information of China (English)

    商鸣宇; 王辰; 代华平; 杨媛华; 姜超美

    2003-01-01

    Objective To investigate the changes in respiratory and circulatory functions in chronic obstructive pulmonary disease (COPD) patients during sequential invasive-noninvasive mechanical ventilation therapy, and evaluate the effects of this new technique.Methods Twelve COPD patients with type Ⅱ respiratory failure due to severe pulmonary infection were ventilated through an endotracheal tube. When the pulmonary infection control window (PIC-Window) occurred, the patients were extubated and were ventilated with a facial mask using pressure support ventilation combined with positive end-expiratory pressure. The parameters of hemodynamics, oxygen dynamics, and esophageal pressure were measured at the PIC-Window during invasive mechanical ventilation, one hour after oxygen therapy via a naso-tube, and three hours after non-invasive mechanical ventilation. Results The variation in esophageal pressure was 20.0±6 cmH2O during naso-tube oxygen therapy, and this variation was higher than that during non-invasive mechanical ventilation (10±6 cmH2O, P0.05).Conclusions The respiratory and circulatory functions of COPD patients remained stable during sequential invasive-noninvasive mechanical ventilation therapy using PIC-Window as a switch point for early extubation. The COPD patients can tolerated the transition from invasive mechanical ventilation to noninvasive mechanical ventilation.

  7. Decision Support Systems - Technical Prerequisites and Military Requirements

    CERN Document Server

    Tolk, Andreas

    2010-01-01

    Decision Support Systems in the sense of online alternative course of action (ACAO) development and analysis as well as tools for online Development of Doctrine and Tactics Techniques, and Procedures (DTTP) for support to operations make it possible to evaluate and forecast the command and control processes and the performance capabilities of the friendly and enemy forces and other decision relevant factors, support the military commander (brigade and higher) and his staff in their headquarter by increasing their ability to identify own opportunities, support all phases of the command and control process, use computer based, automatic and closed models, that can be adapted to the current situation. Objective of the paper is to present the results of studies conducted in Germany on behalf of the German Ministry of Defense with the objective to work out the conceptual basis for decision support systems and to evaluate, how this technique will influence the command and control system of the army of the federal a...

  8. The Spartan attitude control system - Ground support computer

    Science.gov (United States)

    Schnurr, R. G., Jr.

    1986-01-01

    The Spartan Attitude Control System (ACS) contains a command and control computer. This computer is optimized for the activities of the flight and contains very little human interface hardware and software. The computer system provides the technicians testing of Spartan ACS with a convenient command-oriented interface to the flight ACS computer. The system also decodes and time tags data automatically sent out by the flight computer as key events occur. The duration and magnitude of all system maneuvers is also derived and displayed by this system. The Ground Support Computer is also the primary Ground Support Equipment for the flight sequencer which controls all payload maneuvers, and long term program timing.

  9. Decision Support Systems for Research and Management in Advanced Life Support

    Science.gov (United States)

    Rodriquez, Luis F.

    2004-01-01

    Decision support systems have been implemented in many applications including strategic planning for battlefield scenarios, corporate decision making for business planning, production planning and control systems, and recommendation generators like those on Amazon.com(Registered TradeMark). Such tools are reviewed for developing a similar tool for NASA's ALS Program. DSS are considered concurrently with the development of the OPIS system, a database designed for chronicling of research and development in ALS. By utilizing the OPIS database, it is anticipated that decision support can be provided to increase the quality of decisions by ALS managers and researchers.

  10. A System for Supporting Cross-Lingual Information Retrieval.

    Science.gov (United States)

    Capstick, Joanne; Diagne, Abdel Kader; Erbach, Gregor; Uszkoreit, Hans; Leisenberg, Anne; Leisenberg, Manfred

    2000-01-01

    Describes the MULINEX system that supports cross-lingual searching of the World Wide Web. Users can formulate queries, filter the search results and read documents by using their native language. Discusses dictionary-based query translation, multilingual document categorization, and automatic translation that supports French, German, and English.…

  11. Micro-based decision support systems for stock farmers

    OpenAIRE

    H.C. De Kock; Sinclair, M. (Michael)

    2003-01-01

    Decision support systems were developed for use on stock farms. The systems were designed to run on Commodore 8032 microcomputers. They give the user quantitative results on which decisions such as feed mixes, sale of livestock, work programmes, etc can be based. In this paper these systems are described and illustrated with printouts from sample runs.

  12. Funds support the construction of control systems design

    Science.gov (United States)

    Vlasov, V.; Tolokonsky, A.

    2016-08-01

    The experience of the creation tools to support the construction of control systems design skills to provide effective training for students of the Department of Automation MEPhI, to create management information systems based on PCS. Currently the control system have been widely used not only in industry, but also on research. Therefore, quite important question of training in research automation.

  13. Johnson Space Center's Regenerative Life Support Systems Test Bed.

    Science.gov (United States)

    Barta, D J; Henninger, D L

    1996-01-01

    The Regenerative Life Support Systems (RLSS) Test Bed at NASA's Johnson Space Center is an atmospherically closed, controlled environment facility for human testing of regenerative life support systems using higher plants in conjunction with physicochemical life support systems. The facility supports NASA's Advanced Life Support (ALS) Program. The facility is comprised of two large scale plant growth chambers, each with approximately 11 m2 growing area. The root zone in each chamber is configurable for hydroponic or solid media plant culture systems. One of the two chambers, the Variable Pressure Growth Chamber (VPGC), is capable of operating at lower atmospheric pressures to evaluate a range of environments that may be used in a planetary surface habitat; the other chamber, the Ambient Pressure Growth Chamber (APGC) operates at ambient atmospheric pressure. The air lock of the VPGC is currently being outfitted for short duration (1 to 15 day) human habitation at ambient pressures. Testing with and without human subjects will focus on 1) integration of biological and physicochemical air and water revitalization systems; 2) effect of atmospheric pressure on system performance; 3) planetary resource utilization for ALS systems, in which solid substrates (simulated planetary soils or manufactured soils) are used in selected crop growth studies; 4) environmental microbiology and toxicology; 5) monitoring and control strategies; and 6) plant growth systems design. Included are descriptions of the overall design of the test facility, including discussions of the atmospheric conditioning, thermal control, lighting, and nutrient delivery systems.

  14. SUPPORTING SALESPERSONS' CRM EFFORTS THROUGH LOCATION-BASED MOBILE SUPPORT SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    Chihab BENMOUSSA

    2005-01-01

    This paper aims at assessing how location-based mobile support systems can support salespersons' CRM efforts when they are operating within a highly mobile work environment. After briefly discussing the state-of-the-art issues associated with mobile location technologies, the paper conceptualizes key dimensions for location-based mobile support systems. The paper then discusses the dual role of salespersons in CRM. A fourth section suggests a categorization of salespersons'CRM tasks based on both properties of location-based mobile support and the areas of salespersons'CRM-related tasks that may be affected by mobile location technologies. Finally, the paper suggests potential mobile location services and applications that can help salespersons perform effectively their everyday CRM tasks and link such applications to the determinant of salespersons' performance. The paper concludes with a discussion of some critical issues and suggests areas for further research.

  15. Novel Composite Membrane for Space Life Supporting System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Space life-supporting systems require effective removal of metabolic CO2 from the cabin atmosphere with minimal loss of O2. Conventional techniques, using either...

  16. Marketing Decision Support Systems: Adoption, Use and Satisfaction

    NARCIS (Netherlands)

    B. Wierenga (Berend); P.A.M. Oude Ophuis

    1997-01-01

    textabstractThis paper deals with marketing decision support systems (MDSS) in companies. In a conceptual framework five categories of factors are distinguished that potentially affect adoption, use, and satisfaction: external environment factors, organizational factors, task environment factors, us

  17. Marketing decision support systems: Adoption, use and satisfaction.

    NARCIS (Netherlands)

    Wierenga, B.; Oude Ophuis, P.A.M.

    1997-01-01

    This paper deals with marketing decision support systems (MDSS) in companies. In a conceptual framework five categories of factors are distinguished that potentially affect adoption, use, and satisfaction: external environment factors, organizational factors, task environment factors, user factors a

  18. MODIS-Based Products for Operational Decision Support Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — SMH Consulting proposes to develop a web-based decision support system to assist in Rapid Assessment, Monitoring, and Management (RAMM-DSS) on a regional scale. SMH...

  19. A proposed ecosystem services classification system to support green accounting

    Science.gov (United States)

    There are a multitude of actual or envisioned, complete or incomplete, ecosystem service classification systems being proposed to support Green Accounting. Green Accounting is generally thought to be the formal accounting attempt to factor environmental production into National ...

  20. Engineering Next Generation Launch Systems for Supportability Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In order to meet the challenges of high probability of mission success for space exploration, ground support system for various launch operations that responds...

  1. Overview of NASA's Environmental Control and Life Support Systems

    Science.gov (United States)

    Roman, Monserrate

    2009-01-01

    This viewgraph presentation reviews NASA's Environmental Control and Life Support Systems (ECLSS) on the International Space Station. A look inside of the International Space Station detailing ECLSS processes of controlling atmospheric pressure, conditioning the atmosphere, responding to emergency conditions, controlling internal carbon dioxide and contaminants and providing water are described. A detailed description of ISS Regenerative Environmental Control and Life Support System is also presented.

  2. Coherent Frameworks for Statistical Inference serving Integrating Decision Support Systems

    OpenAIRE

    2015-01-01

    A subjective expected utility policy making centre, managing complex, dynamic systems, needs to draw on the expertise of a variety of disparate panels of experts and integrate this information coherently. To achieve this, diverse supporting probabilistic models need to be networked together, the output of one model providing the input to the next. In this paper we provide a technology for designing an integrating decision support system and to enable the centre to explore and compare the effi...

  3. A Components Library System Model and the Support Tool

    Institute of Scientific and Technical Information of China (English)

    MIAO Huai-kou; LIU Hui; LIU Jing; LI Xiao-bo

    2004-01-01

    Component-based development needs a well-designed components library and a set of support tools.This paper presents the design and implementation of a components library system model and its support tool UMLCASE.A set of practical CASE tools is constructed.UMLCASE can use UML to design Use Case Diagram, Class Diagram etc.And it integrates with components library system.

  4. Computer support system for residential environment evaluation for citizen participation

    Institute of Scientific and Technical Information of China (English)

    GE Jian; TEKNOMO Kardi; LU Jiang; HOKAO Kazunori

    2005-01-01

    Though the method of citizen participation in urban planning is quite well established, for a specific segment of residential environment, however, existing participation system has not coped adequately with the issue. The specific residential environment has detailed aspects that need positive and high level involvement of the citizens in participating in all stages and every field of the plan. One of the best and systematic methods to obtain a more involved citizen is through a citizen workshop. To get a more "educated" citizen who participates in the workshop, a special session to inform the citizen on what was previously gathered through a survey was revealed to be prerequisite before the workshop. The computer support system is one of the best tools for this purpose. This paper describes the development of the computer support system for residential environment evaluation system, which is an essential tool to give more information to the citizens before their participation in public workshop. The significant contribution of this paper is the educational system framework involved in the workshop on the public participation system through computer support, especially for residential environment. The framework, development and application of the computer support system are described. The application of a workshop on the computer support system was commented on as very valuable and helpful by the audience as it resulted in greater benefit to have wider range of participation, and deeper level of citizen understanding.

  5. Local regulator adrenomedullin contributes to the circulatory disturbance in cirrhotic rats

    Institute of Scientific and Technical Information of China (English)

    Shinya Sakurai; Hideyuki Kojima; Masahito Uemura; Hiroyasu Satoh; Hiroshi Fukui

    2006-01-01

    AIM: To investigate whether adrenomedullin, a potent vasodilator peptide, plays a role in the circulatory disturbance in cirrhosis.METHODS: Cirrhosis was induced in rats by weekly gavage of carbon tetrachloride. Hemodynamic studies were performed in vivo using radioactive microspheres andin vitro using isolated aortic rings.The adrenomedullin concentrations were measured by radioimmunoassay.RESULTS: Acute administration of adrenomedullin to the control rats reduced the systemic arterial pressure along with an increase of serum levels of the stable metabolite of nitric oxide (NOx), in a dose-dependent manner. Chronic infusion of adrenomedullin reduced the vascular resistance and increased the blood flow in the systemic and splanchnic circulation. Intravenous administration of anti-adrenomedullin antibody did not affect any hemodynamic parameters in the cirrhotic rats, whereas this antibody ameliorated the blunted contractile response to phenylephrine, a-adrenergic receptor agonist, in the aortic rings of the cirrhotic rats.The adrenomedullin concentrations in the aorta were higher in the cirrhotic rats than in the controls, and correlated with the mean arterial pressure in the cirrhotic rats. Moreover, adrenomedullin blunted the contractile response to phenylephrine in both of the control aorta and cirrhotic aorta, but not in the presence of NG-nitroL-arginine methyl ester, an NO synthase inhibitor.CONCLUSION: Adrenomedullin overproduced in the vascular wall may contribute to the circulatory disturbance in cirrhosis as a local regulator of the vascular tonus rather than a circulating hormone.

  6. Autonomic Circulatory Control during Pregnancy in Humans

    OpenAIRE

    2009-01-01

    Pregnancy is associated with dramatic alterations in maternal hemodynamics, which begin early (i.e., following conception, 4 to 5 weeks of gestation) and are accompanied by changing levels of various pressor hormones and vasoactive metabolites. It has been proposed that these changes occur through autonomic control mechanisms, but the actual role of the autonomic nervous system in pregnancy is poorly understood. New research has shed more light on the links between pregnancy and cardiovascula...

  7. Prediction of Banking Systemic Risk Based on Support Vector Machine

    Directory of Open Access Journals (Sweden)

    Shouwei Li

    2013-01-01

    Full Text Available Banking systemic risk is a complex nonlinear phenomenon and has shed light on the importance of safeguarding financial stability by recent financial crisis. According to the complex nonlinear characteristics of banking systemic risk, in this paper we apply support vector machine (SVM to the prediction of banking systemic risk in an attempt to suggest a new model with better explanatory power and stability. We conduct a case study of an SVM-based prediction model for Chinese banking systemic risk and find the experiment results showing that support vector machine is an efficient method in such case.

  8. EXPLOITATION OF LIFE SUPPORT SYSTEMS IN POPULATED PLACES

    Directory of Open Access Journals (Sweden)

    Rudchenko I. I.

    2015-10-01

    Full Text Available This article describes aspects of control, regulation, functioning and degree of influence on the condition of life-support systems, on the safety of life support, on the safety vital functions of society. The impact of life-support systems on the ecological status of builtup areas. The article refers to an increase in emissions and the dangers of СО2 и SО2, about methods to reduce them. It presents the dangers of hydrogen compounds, nitrogen, chlorine, freon. We have also presented measures to protect the environment in urban areas

  9. Nikishin systems are perfect. Case of unbounded and touching supports

    CERN Document Server

    Prieto, Fidalgo; Lagomasino, G López

    2010-01-01

    K. Mahler introduced the concept of perfect systems in the theory of simultaneous Hermite-Pad\\'{e} approximation of analytic functions. Recently, we proved that Nikishin systems, generated by measures with bounded support and non-intersecting consecutive supports contained on the real line, are perfect. Here, we prove that they are also perfect when the supports of the generating measures are unbounded or touch at one point. As an application, we give a version of Stieltjes' theorem in the context of simultaneous Hermite-Pad\\'e approximation.

  10. MPI support in the DIRAC Pilot Job Workload Management System

    Science.gov (United States)

    Tsaregorodtsev, A.; Hamar, V.

    2012-12-01

    Parallel job execution in the grid environment using MPI technology presents a number of challenges for the sites providing this support. Multiple flavors of the MPI libraries, shared working directories required by certain applications, special settings for the batch systems make the MPI support difficult for the site managers. On the other hand the workload management systems with Pilot Jobs became ubiquitous although the support for the MPI applications in the Pilot frameworks was not available. This support was recently added in the DIRAC Project in the context of the GISELA Latin American Grid Initiative. Special services for dynamic allocation of virtual computer pools on the grid sites were developed in order to deploy MPI rings corresponding to the requirements of the jobs in the central task queue of the DIRAC Workload Management System. Pilot Jobs using user space file system techniques install the required MPI software automatically. The same technique is used to emulate shared working directories for the parallel MPI processes. This makes it possible to execute MPI jobs even on the sites not supporting them officially. Reusing so constructed MPI rings for execution of a series of parallel jobs increases dramatically their efficiency and turnaround. In this contribution we describe the design and implementation of the DIRAC MPI Service as well as its support for various types of MPI libraries. Advantages of coupling the MPI support with the Pilot frameworks are outlined and examples of usage with real applications are presented.

  11. A new scenario based approach for designing driver support systems applied to the design of a lane change support system

    NARCIS (Netherlands)

    Tideman, M.; Voort, M.C. van der; Arem, B. van

    2010-01-01

    Designing a new driver support system that meets the expectations of drivers is a difficult and time-consuming process. Despite the availability of various types of design support, it has essentially remained a process in which designers are forced to make assumptions about what other people want. T

  12. Impella ventricular support in clinical practice

    DEFF Research Database (Denmark)

    Burzotta, Francesco; Trani, Carlo; Doshi, Sagar N;

    2015-01-01

    Mechanical circulatory support represents an evolving field of clinical research and practice. Currently, several cardiac assist devices have been developed but, among different institutions and countries, a large variation in indications for use and device selection exists. The Impella platform ...

  13. Evolution of Decision Support Systems Research Field in Numbers

    Directory of Open Access Journals (Sweden)

    Ana-Maria SUDUC

    2010-01-01

    Full Text Available The scientific production in a certain field shows, in great extent, the research interests in that field. Decision Support Systems are a particular class of information systems which are gaining more popularity in various domains. In order to identify the evolution in time of the publications number, authors, subjects, publications in the Decision Support Systems (DSS field, and therefore the scientific world interest for this field, in November 2010 there have been organized a series of queries on three major international scientific databases: ScienceDirect, IEEE Xplore Digital Library and ACM Digital Library. The results presented in this paper shows that, even the decision support systems research field started in 1960s, the interests for this type of systems grew exponentially with each year in the last decades.

  14. Web-Based Group Decision Support System: an Economic Application

    Directory of Open Access Journals (Sweden)

    Ion ISTUDOR

    2010-01-01

    Full Text Available Decision Support Systems (DSS form a specific class of computerized information systems that support business and managerial decision-making activities. Making the right decision in business primarily depends on the quality of data. It also depends on the ability to analyze the data with a view to identifying trends that can suggest solutions and strategies. A “cooperative” decision support system means the data are collected, analyzed and then provided to a human agent who can help the system to revise or refine the data. It means that both a human component and computer component work together to come up with the best solution. This paper describes the usage of a software product (Vanguard System to a specific economic application (evaluating the financial risk assuming that the rate of the economic profitability can be under the value of the interest rate.

  15. Decision support systems for robotic surgery and acute care

    Science.gov (United States)

    Kazanzides, Peter

    2012-06-01

    Doctors must frequently make decisions during medical treatment, whether in an acute care facility, such as an Intensive Care Unit (ICU), or in an operating room. These decisions rely on a various information sources, such as the patient's medical history, preoperative images, and general medical knowledge. Decision support systems can assist by facilitating access to this information when and where it is needed. This paper presents some research eorts that address the integration of information with clinical practice. The example systems include a clinical decision support system (CDSS) for pediatric traumatic brain injury, an augmented reality head- mounted display for neurosurgery, and an augmented reality telerobotic system for minimally-invasive surgery. While these are dierent systems and applications, they share the common theme of providing information to support clinical decisions and actions, whether the actions are performed with the surgeon's own hands or with robotic assistance.

  16. ARCHITECTURE SOFTWARE SOLUTION TO SUPPORT AND DOCUMENT MANAGEMENT QUALITY SYSTEM

    Directory of Open Access Journals (Sweden)

    Milan Eric

    2010-12-01

    Full Text Available One of the basis of a series of standards JUS ISO 9000 is quality system documentation. An architecture of the quality system documentation depends on the complexity of business system. An establishment of an efficient management documentation of system of quality is of a great importance for the business system, as well as in the phase of introducing the quality system and in further stages of its improvement. The study describes the architecture and capability of software solutions to support and manage the quality system documentation in accordance with the requirements of standards ISO 9001:2001, ISO 14001:2005 HACCP etc.

  17. Intelligent Decision Support System for Bank Loans Risk Classification

    Institute of Scientific and Technical Information of China (English)

    杨保安; 马云飞; 俞莲

    2001-01-01

    Intelligent Decision Support System (IISS) for Bank Loans Risk Classification (BLRC), based on the way of integration Artificial Neural Network (ANN) and Expert System (ES), is proposed. According to the feature of BLRC, the key financial and non-financial factors are analyzed. Meanwhile, ES and Model Base (MB) which contain ANN are designed . The general framework,interaction and integration of the system are given. In addition, how the system realizes BLRC is elucidated in detail.

  18. Control, Operator Support and Safety System of PVC-reactors

    Directory of Open Access Journals (Sweden)

    Jens I. Ytreeide

    1997-01-01

    Full Text Available In modern petrochemical plants the corporate and societal demands to plant safety and minimum environmental effects are high. These demands rise high performance requirements to the technical systems, specially the process control and safety systems including an effective operator support system with fault detection capability. The systems must have high reliability also against erroneous operations which may cause shutdown situations or quality deviations.

  19. Control, operator support and safety system of PVC reactors

    Energy Technology Data Exchange (ETDEWEB)

    Ytreeide, J.I.; Aaker, O.; Kristoffersen, V.; Moe, G.; Naustdal, C.

    1997-06-01

    In modern petrochemical plants the corporate and societal demands to plant safety and minimum environmental effects are high. These demands rise high performance requirements to the technical systems, specially the process control and safety systems including an effective operator support system with fault detection capability. PVC producing plants have high inherent hazard potentials, and the studied reaction in this publication is exothermic and non-linear and open-loop unstable, and the plant is equipped with two independent cooling systems to keep the reaction under control. A system to solve the stability problem of parallel control is suggested, showing the simulation of real process data. The publication describes an operator support system for monitoring the heat of reaction in the autoclave consisting of a model based estimator. The system is tested on-line, and the results of simulations and on-line estimates are presented. 6 refs., 13 figs.

  20. Software Application for Supporting the Education of Database Systems

    Science.gov (United States)

    Vágner, Anikó

    2015-01-01

    The article introduces an application which supports the education of database systems, particularly the teaching of SQL and PL/SQL in Oracle Database Management System environment. The application has two parts, one is the database schema and its content, and the other is a C# application. The schema is to administrate and store the tasks and the…

  1. Information systems to support surveillance for malaria elimination.

    Science.gov (United States)

    Ohrt, Colin; Roberts, Kathryn W; Sturrock, Hugh J W; Wegbreit, Jennifer; Lee, Bruce Y; Gosling, Roly D

    2015-07-01

    Robust and responsive surveillance systems are critical for malaria elimination. The ideal information system that supports malaria elimination includes: rapid and complete case reporting, incorporation of related data, such as census or health survey information, central data storage and management, automated and expert data analysis, and customized outputs and feedback that lead to timely and targeted responses. Spatial information enhances such a system, ensuring cases are tracked and mapped over time. Data sharing and coordination across borders are vital and new technologies can improve data speed, accuracy, and quality. Parts of this ideal information system exist and are in use, but have yet to be linked together coherently. Malaria elimination programs should support the implementation and refinement of information systems to support surveillance and response and ensure political and financial commitment to maintain the systems and the human resources needed to run them. National malaria programs should strive to improve the access and utility of these information systems and establish cross-border data sharing mechanisms through the use of standard indicators for malaria surveillance. Ultimately, investment in the information technologies that support a timely and targeted surveillance and response system is essential for malaria elimination.

  2. A support system for predicting eBay end prices.

    NARCIS (Netherlands)

    D.P. van Heijst (Dennis); R. Potharst (Rob); M.C. van Wezel (Michiel)

    2006-01-01

    textabstractIn this report a support system for predicting end prices on eBay is proposed. The end price predictions are based on the item descriptions found in the item listings of eBay, and on some numerical item features. The system uses text mining and boosting algorithms from the field of mach

  3. A Support System for Error Correction Questions in Programming Education

    Science.gov (United States)

    Hachisu, Yoshinari; Yoshida, Atsushi

    2014-01-01

    For supporting the education of debugging skills, we propose a system for generating error correction questions of programs and checking the correctness. The system generates HTML files for answering questions and CGI programs for checking answers. Learners read and answer questions on Web browsers. For management of error injection, we have…

  4. Computer System Reliability Allocation Method and Supporting Tool

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    This paper presents a computer system reliability allocationmethod that is based on the theory of statistic and Markovian chain,which can be used to allocate reliability to subsystem, to hybrid system and software modules. Arele vant supporting tool built by us is introduced.

  5. A Support System to Tie Apron Strings to Debris Flow

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ Scientists from the Chengdubased CAS Institute of Mountain Hazards and Environment (IMHE) recently worked out a decision-making support system for disaster mitigation on debris fans in mountainous regions.As a domestic vanguard, the system plays a key role in the fight against debris flow and helping to reduce casualties.

  6. The use of VEPs for CNS monitoring during continuous cardiopulmonary bypass and circulatory arrest.

    Science.gov (United States)

    Keenan, N K; Taylor, M J; Coles, J G; Prieur, B J; Burrows, F A

    1987-07-01

    Cerebral function was monitored with the use of visual evoked potentials (VEPs) in 16 infants (mean age 9.9 +/- 4.3 months) during surgery for congenital cardiac anomalies. While hypothermia was employed in all patients, half (8) remained on continuous cardiopulmonary bypass (CCB) while the rest were cooled to lower temperatures before the induction of circulatory stasis and venous exsanguination (CA), i.e., profound hypothermic circulatory arrest (PHCA). VEPs were recorded before, during and after surgical intervention. Latency changes occurred in both the N100 and P145 components of the VEP as a function of systemic temperature during cooling in both groups. Differences in the VEPs were found between the two groups post-operatively, with the most interesting result being a greater increase in P145 latency in the CA group after rewarming. To the extent that VEPs reflect neurological status, our findings suggested that CCB was associated with less perturbation in acute neurological status than PHCA, and shorter arrest times and lower temperatures during CA were associated with the most favourable post-operative VEPs. Hence, intraoperative monitoring of VEPs appeared to be useful as an objective measure of the short-term effects of various cardiopulmonary procedures on neurophysiological function.

  7. Revisiting the dose calculation methodologies in European decision support systems

    DEFF Research Database (Denmark)

    Andersson, Kasper Grann; Roos, Per; Hou, Xiaolin;

    2012-01-01

    in connection with management of the consequences of other types of contaminating incidents, including ‘dirty bomb’ explosions. This would require a number of new modelling features and parametric changes. Also for nuclear power plant preparedness a number of revisions of the decision support systems are called......The paper presents examples of current needs for improvement and extended applicability of the European decision support systems. The systems were originally created for prediction of the radiological consequences of accidents at nuclear installations. They could however also be of great value...

  8. The Intelligent Decision Support System Model of SARS

    Institute of Scientific and Technical Information of China (English)

    ZhouXingyu; ZhangJiang; LiuYang; XieYanqing; ZhangRan; ZhaoYang; HeZhongxiong

    2004-01-01

    Based on the intelligent decision support system, a new method was presented to defense the catastrophic infectious disease such as SARS, Bird Flu, etc.. By using All Set theory, the decision support system (DSS) model can be built to analyze the noise information and forecast the trend of the catastrophe then to give the method or policy to defend the disease. The model system is composed of four subsystems: the noise analysis subsystem, forecast and simulation subsystem, diagnosis subsystem and second recovery subsystem. They are discussed briefly in this paper. This model can be used not only for SARS but also for other paroxysmal accidences.

  9. An Open Challenge Problem Repository for Systems Supporting Binders

    Directory of Open Access Journals (Sweden)

    Amy Felty

    2015-07-01

    Full Text Available A variety of logical frameworks support the use of higher-order abstract syntax in representing formal systems; however, each system has its own set of benchmarks. Even worse, general proof assistants that provide special libraries for dealing with binders offer a very limited evaluation of such libraries, and the examples given often do not exercise and stress-test key aspects that arise in the presence of binders. In this paper we design an open repository ORBI (Open challenge problem Repository for systems supporting reasoning with BInders. We believe the field of reasoning about languages with binders has matured, and a common set of benchmarks provides an important basis for evaluation and qualitative comparison of different systems and libraries that support binders, and it will help to advance the field.

  10. Methodology and Assumptions of Contingency Shuttle Crew Support (CSCS) Calculations Using ISS Environmental Control and Life Support Systems

    Science.gov (United States)

    Prokhorov, Kimberlee; Shkedi, Brienne

    2006-01-01

    The current International Space Station (ISS) Environmental Control and Life Support (ECLS) system is designed to support an ISS crew size of three people. The capability to expand that system to support nine crew members during a Contingency Shuttle Crew Support (CSCS) scenario has been evaluated. This paper describes how the ISS ECLS systems may be operated for supporting CSCS, and the durations expected for the oxygen supply and carbon dioxide control subsystems.

  11. Marketing Decision Making and Decision Support: Challenges and Perspectives for Successful Marketing Management Support Systems

    NARCIS (Netherlands)

    G.H. van Bruggen (Gerrit); B. Wierenga (Berend)

    2009-01-01

    textabstractMarketing management support systems (MMSS) are computer-enabled devices that help marketers to make better decisions. Marketing processes can be quite complex, involving large numbers of variables and mostly outcomes are the results of the actions of many different stakeholders (e.g., t

  12. Nanomaterials for Advanced Life Support in Advanced Life Support in Space systems

    Science.gov (United States)

    Allada, Rama Kumar; Moloney, Padraig; Yowell, Leonard

    2006-01-01

    A viewgraph presentation describing nanomaterial research at NASA Johnson Space Center with a focus on advanced life support in space systems is shown. The topics include: 1) Introduction; 2) Research and accomplishments in Carbon Dioxide Removal; 3) Research and Accomplishments in Water Purification; and 4) Next Steps

  13. Intelligent car guidance system (parking support system); Chiteki sharyo yudo system (chusha shien system)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    This system enables a driver to park the car at a predetermined spot without the driver seeing the outside scene. The system shows on a driver seat display the steps that the driver is to follow and thereby supports the driver when visibility is poor, when the parking space is difficult to approach, when the driver is a novice, or when the driver is aged. The system ensures accurate positioning of the car by showing the steering direction and angle, the car speed, and the force of braking to the driver. For this purpose, the system knows the absolute car position by the use of an RFID (Radio Frequency Identification) tag which is a kind of IC (Integrated Circuit) card and D-GPS (Differential-Global Positioning System), grasps the relative car position by the use of a gyroscope, and collects data from plural sensors, which are complementary to each other, such as a car-speed sensor and a steering sensor. (translated by NEDO)

  14. A Automated Tool for Supporting FMEAs of Digital Systems

    Energy Technology Data Exchange (ETDEWEB)

    Yue,M.; Chu, T.-L.; Martinez-Guridi, G.; Lehner, J.

    2008-09-07

    Although designs of digital systems can be very different from each other, they typically use many of the same types of generic digital components. Determining the impacts of the failure modes of these generic components on a digital system can be used to support development of a reliability model of the system. A novel approach was proposed for such a purpose by decomposing the system into a level of the generic digital components and propagating failure modes to the system level, which generally is time-consuming and difficult to implement. To overcome the associated issues of implementing the proposed FMEA approach, an automated tool for a digital feedwater control system (DFWCS) has been developed in this study. The automated FMEA tool is in nature a simulation platform developed by using or recreating the original source code of the different module software interfaced by input and output variables that represent physical signals exchanged between modules, the system, and the controlled process. For any given failure mode, its impacts on associated signals are determined first and the variables that correspond to these signals are modified accordingly by the simulation. Criteria are also developed, as part of the simulation platform, to determine whether the system has lost its automatic control function, which is defined as a system failure in this study. The conceptual development of the automated FMEA support tool can be generalized and applied to support FMEAs for reliability assessment of complex digital systems.

  15. Fuzzy rule-based support vector regression system

    Institute of Scientific and Technical Information of China (English)

    Ling WANG; Zhichun MU; Hui GUO

    2005-01-01

    In this paper,we design a fuzzy rule-based support vector regression system.The proposed system utilizes the advantages of fuzzy model and support vector regression to extract support vectors to generate fuzzy if-then rules from the training data set.Based on the first-order linear Tagaki-Sugeno (TS) model,the structure of rules is identified by the support vector regression and then the consequent parameters of rules are tuned by the global least squares method.Our model is applied to the real world regression task.The simulation results gives promising performances in terms of a set of fuzzy rules,which can be easily interpreted by humans.

  16. Hypermedia support for engineering design systems: Application to fatigue analysis

    Science.gov (United States)

    Saeaeski, Juha; Sipilae, Sisko; Marquis, Gary

    1992-12-01

    The possibilities of using hypermedia for supporting engineering design systems are discussed. The application selected to test the hypermedia ideas was fatigue analysis. In addition, the possibility of combining hypermedia and expert system ideas into a fatigue expert system is reported. Hypermedia's underlying notion of linking nodes of information and its capability to handle these information entities stored appear to be well suited for engineering system support systems, especially in those engineering design systems where there exists a great demand for representing graphical information in a convenient way. This can be realized using hypermedia tools that are based on hypermedia techniques. The resulting fatigue handbook covers only part of the hypermedia's possibilities. The development of a prototype application indicates the efficiency of a hypermedia tool to create an electronic manual.

  17. A decision support system for AIDS intervention and prevention.

    Science.gov (United States)

    Xu, L D

    1994-08-01

    In recent years, the importance of information systems has been identified as a vital issue to continuing success in AIDS intervention and prevention (AIP). The advances in information technology have resulted in integrative information systems including decision support systems (DSS). The concept of DSS for AIP was created at the intersection of two trends. The first trend was a growing belief that AIP information systems are successful in automating operations in AIP programs. The second was a continuing improvement in modeling and software development in the AIP area. This paper presents an integrated DSS for AIP. The system is integrated with a database and achieves its efficiency by incorporating various algorithms and models to support AIP decision processes. The application examples include screening AIDS-risky behaviors, evaluating educational interventions, and scheduling AIP sessions. The implementation results present evidence of the usefulness of the system in AIP.

  18. Behavior-aware decision support systems : LDRD final report.

    Energy Technology Data Exchange (ETDEWEB)

    Hirsch, Gary B.; Homer, Jack (Homer Consulting); Chenoweth, Brooke N.; Backus, George A.; Strip, David R.

    2007-11-01

    As Sandia National Laboratories serves its mission to provide support for the security-related interests of the United States, it is faced with considering the behavioral responses that drive problems, mitigate interventions, or lead to unintended consequences. The effort described here expands earlier works in using healthcare simulation to develop behavior-aware decision support systems. This report focuses on using qualitative choice techniques and enhancing two analysis models developed in a sister project.

  19. Medical decision support systems and therapeutics: The role of autopilots.

    Science.gov (United States)

    Woosley, R L; Whyte, J; Mohamadi, A; Romero, K

    2016-02-01

    For decades, medical practice has increasingly relied on prescription medicines to treat, cure, or prevent illness but their net benefit is reduced by prescribing errors that result in adverse drug reactions (ADRs) and tens of thousands of deaths each year. Optimal prescribing requires effective management of massive amounts of data. Clinical decision support systems (CDSS) can help manage information and support optimal therapeutic decisions before errors are made by operating as the prescribers' "autopilot."

  20. PERFUSION SYSTEM CONTROLLER STRATEGIES DURING AN ECMO SUPPORT

    OpenAIRE

    2014-01-01

    In this work modelling and control of Perfusion system is presented. The Perfusion system simultaneously controls the partial pressures during Extra Corporeal Membrane Oxygenation (ECMO) support. The main Problem in ECMO system is exchange of Blood Gases in the Artificial Lung (Oxygenator).It is a highly Nonlinear Process comprising time-varying parameters, and varying time delays, it is currently being controlled manually by trained Perfusionist. The new control strategy implemen...

  1. Decision support system for containment and release management

    Energy Technology Data Exchange (ETDEWEB)

    Oosterhuis, B. [Twente Univ., Enschede (Netherlands). Computer Science Dept.

    1995-09-01

    The Containment and Release Management project was carried out within the Reinforced Concerted Action Programme for Accident Management Support and partly financed by the European Union. In this report a prototype of an accident management support system is presented. The support system integrates several concepts from accident management research, like safety objective trees, severe accident phenomena, calculation models and an emergency response data system. These concepts are provided by the prototype in such a way that the decision making process of accident management is supported. The prototype application is demonstrated by process data taken from a severe accident scenario for a pressurized water reactor (PWR) that was simulated with the thermohydraulic computer program MAAP. The prototype was derived from a decision support framework based on a decision theory. For established and innovative concepts from accident management research it is pointed out in which way these concepts can support accident management and how these concepts can be integrated. This approach is generic in two ways; it applies to both pressurized and boiling water reactors and it applies to both in vessel management and containment and release management. The prototype application was developed in Multimedia Toolbox 3.0 and requires at least a 386 PC with 4 MB memory, 6 MB free disk space and MS Windows 3.1. (orig.).

  2. Closure of regenerative life support systems: results of the Lunar-Mars Life Support Test Project

    Science.gov (United States)

    Barta, D.; Henninger, D.; Edeen, M.; Lewis, J.; Smith, F.; Verostko, C.

    Future long duration human exploration missions away from Earth will require closed-loop regenerative life support systems to reduce launch mass reduce dependency on resupply and increase the level of mission self sufficiency Such systems may be based on the integration of biological and physiocochemical processes to produce potable water breathable atmosphere and nutritious food from metabolic and other mission wastes Over the period 1995 to 1998 a series of ground-based tests were conducted at the National Aeronautics and Space Administration Johnson Space Center to evaluate the performance of advanced closed-loop life support technologies with real human metabolic and hygiene loads Named the Lunar-Mars Life Support Test Project LMLSTP four integrated human tests were conducted with increasing duration complexity and closure The first test LMLSTP Phase I was designed to demonstrate the ability of higher plants to revitalize cabin atmosphere A single crew member spent 15 days within an atmospherically closed chamber containing 11 2 square meters of actively growing wheat Atmospheric carbon dioxide and oxygen levels were maintained by control of the rate of photosynthesis through manipulation of light intensity or the availability of carbon dioxide and included integrated physicochemical systems During the second and third tests LMLSTP Phases II IIa four crew members spent 30 days and 60 days respectively in a larger sealed chamber Advanced physicochemical life support hardware was used to regenerate the atmosphere and produce potable water

  3. A theoretical foundation for building Knowledge-work Support Systems

    CERN Document Server

    Laha, Arijit

    2009-01-01

    In this paper we propose a novel approach aimed at building a new class of information system platforms which we call the "Knowledge-work Support Systems" or KwSS. KwSS can play a significant role in enhancing the IS support for knowledge management processes, including those customarily identified as less amenable to IS support. In our approach we try to enhance basic functionalities provided by the computer-based information systems, namely, that of improving the efficiency of the knowledge workers in accessing, processing and creating useful information. The improvement, along with proper focus on cultural, social and other aspects of the knowledge management processes, can enhance the workers' efficiency significantly in performing high quality knowledge works. In order to build the proposed approach, we develop several new concepts. The approach analyzes the information availability and usage from the knowledge workers and their works' perspectives and consequently brings forth more transparency in vario...

  4. Development of Interactive Industrial Design Support System Considering Customer's Evaluation

    Science.gov (United States)

    Yanagisawa, Hideyoshi; Fukuda, Shuichi

    To respond to rapidly changing and diversifying customers' requirements, an industrial design support system for eyeglass frames which allows the customer to participate in the industrial design process was developed. This system is based on the Interactive Evolutionary Computing (IEC) technique so that a customer can interact with the system to express his or her Kansei requirements through images. The design of an eyeglass frame cannot be determined in isolation but rather must be determined by considering its appearance on the customer. In the developed system, the user evaluates each sample suggested by the system and narrows down the candidate gradually. Its usefulness was demonstrated by operational experiments and questionnaires.

  5. The systems psychodynamic experiences of organisational transformation amongst support staff

    Directory of Open Access Journals (Sweden)

    Martin Steyn

    2016-04-01

    Full Text Available Orientation: The unconscious impact of organisational transformation is often neglected and even denied. This research revealed the manifestation and impact of high levels and different forms of anxiety experienced by employees during transformation.Research objective: The objective was to study and describe the manifesting systems psychodynamic behaviour amongst support staff during organisational transformation.Motivation for the study: Organisational transformation is mostly researched from a leadership viewpoint. Little research data are available on the experiences of support staff on the receiving end of decisions about and implementation of transformation.Research design, approach and method: A qualitative approach within the phenomenological hermeneutic interpretive stance was used. The research was set in a government organisation. A semi-structured interview with four conveniently and purposefully chosen support staff members was thematically analysed using systems psychodynamics as theoretical paradigm.Main findings: Four themes manifested, namely de-authorisation and detachment, being bullied and seduced by leadership, the organisation in the mind as incompetent, and a dangerous and persecutory system. In the discussion, the basic assumptions and relevant constructs are interpreted.Practical implications: Understanding the transformation experiences of support staff could assist the industrial psychologist to facilitate appropriate support in coaching more junior staff towards increasing wellness and work performance.Contribution: Organisational transformation is highlighted as an anxiety provoking experience especially on the lower levels of the organisation. Its potentially deep and complex psychological impact could possibly derail parts of the system if not managed in a psychologically contained manner.

  6. Pricing Decision Support System for Generation Companies in Electricity Market

    Institute of Scientific and Technical Information of China (English)

    FangDebin; WangXianjia

    2005-01-01

    In order to meet the requirement of separating power plants from power network and that of the competition based power transaction in power market, the pricing decision support system for generation companies (GCPDSS) is built in electricity market. This paper introduces the conception of intelligent decision support system (IDSS) and puts emphasis on the systematical structural framework,work process, design principal, and fundamental function of GCPDSS. The system has the module to analyze the cost, to forecast the demand of power, to construct the pricing strategies, to manage the pricing risk, and to dispatch giving the pricing strategies.The case study illustrates that the friendly window-based user interface of the system enables the user to take full advantage of the capabilities of the system in order to make effective real-time decisions.

  7. Information security requirements in patient-centred healthcare support systems.

    Science.gov (United States)

    Alsalamah, Shada; Gray, W Alex; Hilton, Jeremy; Alsalamah, Hessah

    2013-01-01

    Enabling Patient-Centred (PC) care in modern healthcare requires the flow of medical information with the patient between different healthcare providers as they follow the patient's treatment plan. However, PC care threatens the stability of the balance of information security in the support systems since legacy systems fall short of attaining a security balance when sharing their information due to compromises made between its availability, integrity, and confidentiality. Results show that the main reason for this is that information security implementation in discrete legacy systems focused mainly on information confidentiality and integrity leaving availability a challenge in collaboration. Through an empirical study using domain analysis, observations, and interviews, this paper identifies a need for six information security requirements in legacy systems to cope with this situation in order to attain the security balance in systems supporting PC care implementation in modern healthcare.

  8. Computational intelligence for decision support in cyber-physical systems

    CERN Document Server

    Ali, A; Riaz, Zahid

    2014-01-01

    This book is dedicated to applied computational intelligence and soft computing techniques with special reference to decision support in Cyber Physical Systems (CPS), where the physical as well as the communication segment of the networked entities interact with each other. The joint dynamics of such systems result in a complex combination of computers, software, networks and physical processes all combined to establish a process flow at system level. This volume provides the audience with an in-depth vision about how to ensure dependability, safety, security and efficiency in real time by making use of computational intelligence in various CPS applications ranging from the nano-world to large scale wide area systems of systems. Key application areas include healthcare, transportation, energy, process control and robotics where intelligent decision support has key significance in establishing dynamic, ever-changing and high confidence future technologies. A recommended text for graduate students and researche...

  9. ERP System Audit a Control Support For Knowledge Management

    Directory of Open Access Journals (Sweden)

    Traian SURCEL

    2008-01-01

    Full Text Available The ERP system supports most of the business system that maintains in a single database the data needed for a variety of business functions such as Manufacturing, SCM, Financials, Projects, Human Resources and CRM; the audit of this systems is necessary in order to give reasonable assurance to the company on its core system. Obtained evidence evaluation can ensure whether the organization's IT&C system safeguard assets, maintains data integrity, and is operating effectively and efficiently to achieve the organization's goals or objectives. The audit process respecting the methodology based on: gathering information and plan; obtaining an understanding of internal controls; performing test of controls and substantive tests, develop a control support on quality of flow of information and knowledge from formal perspective, for Knowledge Management in large enterprises.

  10. Support mechanisms and risk: Implications on the Nordic electricity system

    DEFF Research Database (Denmark)

    Kitzing, Lena; Ravn, Hans

    2013-01-01

    Investments in renewable energy projects, such as offshore wind parks, are very much dependent on financial support. The type of policy instrument chosen for such support determines investors' exposure to market risk, and thus influences which rate of return they expect to achieve. We make...... a stochastic analysis for the Nordic electricity system by conducting simulations with the energy system model Balmorel and by applying the mean-standard deviation approach of modern portfolio theory to quantify risk implications of policy instruments for an exemplary offshore wind park. The analysis reveals...

  11. Research of Agile Supply Chain Management Decision Support System

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Agile Supply Chain Management (ASCM) is an important topic and has received much attention recently.ASCM is a new management technology.Agile Supply Chain Management Decision Support System (ASCM-DSS) is presented.Firstly, agile supply chain management technology is introduced.Secondly a decision support system for agile supply chain management is proposed.Then, the implementation of ASCM-DSS in enterprise is discussed.Finally, a fuzzy intelligence decision-making process in Shanghai Turbine Generator Company (STGC) is described in detail.

  12. System-agnostic clinical decision support services: benefits and challenges for scalable decision support.

    Science.gov (United States)

    Kawamoto, Kensaku; Del Fiol, Guilherme; Orton, Charles; Lobach, David F

    2010-01-01

    System-agnostic clinical decision support (CDS) services provide patient evaluation capabilities that are independent of specific CDS systems and system implementation contexts. While such system-agnostic CDS services hold great potential for facilitating the widespread implementation of CDS systems, little has been described regarding the benefits and challenges of their use. In this manuscript, the authors address this need by describing potential benefits and challenges of using a system-agnostic CDS service. This analysis is based on the authors' formal assessments of, and practical experiences with, various approaches to developing, implementing, and maintaining CDS capabilities. In particular, the analysis draws on the authors' experience developing and leveraging a system-agnostic CDS Web service known as SEBASTIAN. A primary potential benefit of using a system-agnostic CDS service is the relative ease and flexibility with which the service can be leveraged to implement CDS capabilities across applications and care settings. Other important potential benefits include facilitation of centralized knowledge management and knowledge sharing; the potential to support multiple underlying knowledge representations and knowledge resources through a common service interface; improved simplicity and componentization; easier testing and validation; and the enabling of distributed CDS system development. Conversely, important potential challenges include the increased effort required to develop knowledge resources capable of being used in many contexts and the critical need to standardize the service interface. Despite these challenges, our experiences to date indicate that the benefits of using a system-agnostic CDS service generally outweigh the challenges of using this approach to implementing and maintaining CDS systems.

  13. Management Overview of System Technical Support Plan for the FIREFINDER System Support Center.

    Science.gov (United States)

    1980-08-06

    office spaces h. Cassette duplicating i. Configuration management A- 2 I/ APPENDIX B FFSSC EQUIPMENT This appendix delineates the equipment required by...TSG The Surgeon General TWT Traveling Wave Tube USACDC U.S. Army Combat Developments Command USACSC U.S. Army Computer Systems Command USAEPG U.S. Army...commands and agencies will follow to ensure that the Army has trained and qualified personnel to operate and maintain new or modified systems and equipment

  14. GEOGRAPHICAL INFORMATION SYSTEM, DECISION SUPPORT SYSTEMS, AND URBAN STORMWATER MANAGEMENT

    Science.gov (United States)

    The full report reviews the application of Geographic Inforamtion System (GIS) technology to the field of urban stormwater modeling. The GIS literature is reviewed in the context of its use as a spatial database for urban stormwater modeling, integration of GIS and hydroloic time...

  15. Clinical decision support for perioperative information management systems.

    Science.gov (United States)

    Wanderer, Jonathan P; Ehrenfeld, Jesse M

    2013-12-01

    Clinical decision support (CDS) systems are being used to optimize the increasingly complex care that our health care system delivers. These systems have become increasingly important in the delivery of perioperative care for patients undergoing cardiac, thoracic, and vascular procedures. The adoption of perioperative information management systems (PIMS) has allowed these technologies to enter the operating room and support the clinical work flow of anesthesiologists and operational processes. Constructing effective CDS systems necessitates an understanding of operative work flow and technical considerations as well as achieving integration with existing information systems. In this review, we describe published examples of CDS for PIMS, including support for cardiopulmonary bypass separation physiological alarms, β-blocker guideline adherence, enhanced revenue capture for arterial line placement, and detection of hemodynamic monitoring gaps. Although these and other areas are amenable to CDS systems, the challenges of latency and data reliability represent fundamental limitations on the potential application of these tools to specific types of clinical issues. Ultimately, we expect that CDS will remain an important tool in our efforts to optimize the quality of care delivered.

  16. Field Support System (FS-AID) and Working Capital Fund Tracking System (WCF-TS)

    Data.gov (United States)

    US Agency for International Development — The Field Support System (FS-AID) and Working Capital Fund Tracking System (WCF-TS) are two modules of a single data management system that share common tables and...

  17. Contingency support using adaptive telemetry extractor and expert system technologies

    Science.gov (United States)

    Bryant, Thomas; Cruse, Bryant; Wende, Charles

    The 'telemetry analysis logic for operations support' prototype system constitutes an expert system that is charged with contingency planning for the NASA Hubble Space Telescope (HST); this system has demonstrated the feasibility of using an adaptive telemetry extractor/reformatter that is integrated with an expert system. A test case generated by a simulator has demonstrated the reduction of the time required for analysis of a complex series of failures to a few minutes, from the hour usually required. The HST's telemetry extractor will be able to read real-time engineering telemetry streams and disk-based data. Telemetry format changes will be handled almost instantaneously.

  18. Semantic Interoperability in Clinical Decision Support Systems: A Systematic Review.

    Science.gov (United States)

    Marco-Ruiz, Luis; Bellika, Johan Gustav

    2015-01-01

    The interoperability of Clinical Decision Support (CDS) systems with other health information systems has become one of the main limitations to their broad adoption. Semantic interoperability must be granted in order to share CDS modules across different health information systems. Currently, numerous standards for different purposes are available to enable the interoperability of CDS systems. We performed a literature review to identify and provide an overview of the available standards that enable CDS interoperability in the areas of clinical information, decision logic, terminology, and web service interfaces.

  19. Methodology and Supporting Toolset Advancing Embedded Systems Quality

    DEFF Research Database (Denmark)

    Berger, Michael Stübert; Soler, José; Brewka, Lukasz Jerzy;

    2013-01-01

    Software quality is of primary importance in the development of embedded systems that are often used in safety-critical applications. Moreover, as the life cycle of embedded products becomes increasingly tighter, productivity and quality are simultaneously required and closely interrelated towards...... delivering competitive products. In this context, the MODUS (Methodology and supporting toolset advancing embedded systems quality) project aims to provide a pragmatic and viable solution that will allow SMEs to substantially improve their positioning in the embedded-systems development market. This paper...... will describe the MODUS project with focus on the technical methodologies that will be developed advancing embedded system quality....

  20. Computerised decision support systems for healthcare professionals: an interpretative review

    Directory of Open Access Journals (Sweden)

    Kathrin Cresswell

    2013-03-01

    Full Text Available Purpose Computerised decision support systems are designed to support clinicians in making decisions and thereby enhance the quality and safety of care. We aimed to undertake an interpretative review of the empirical evidence on computerised decision support systems, their contexts of use, and summarise evidence on the effectiveness of these tools and insights into how these can be successfully implemented and adopted.Methods We systematically searched the empirical literature to identify systematic literature reviews on computerised decision support applications and their impact on the quality and safety of healthcare delivery over a 13-year period (1997–2010. The databases searched included: MEDLINE, EMBASE, The Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, The Cochrane Central Register of Controlled Trials, The Cochrane Methodology Register, The Health Technology Assessment Database, and The National Health Service (NHS Economic Evaluation Database. To be eligible for inclusion, systematic reviews needed to address computerised decision support systems, and at least one of the following: impact on safety; quality; or organisational, implementation or adoption considerations.Results Our searches yielded 121 systematic reviews relating to eHealth, of which we identified 41 as investigating computerised decision support systems. These indicated that, whilst there was a lack of investigating potential risks, such tools can result in improvements in practitioner performance in the promotion of preventive care and guideline adherence, particularly if specific information is available in real time and systems are effectively integrated into clinical workflows. However, the evidence regarding impact on patient outcomes was less clear-cut with reviews finding either no, inconsistent or modest benefits.Conclusions Whilst the potential of clinical decision support systems in improving, in particular

  1. EXODUS: Integrating intelligent systems for launch operations support

    Science.gov (United States)

    Adler, Richard M.; Cottman, Bruce H.

    1991-01-01

    Kennedy Space Center (KSC) is developing knowledge-based systems to automate critical operations functions for the space shuttle fleet. Intelligent systems will monitor vehicle and ground support subsystems for anomalies, assist in isolating and managing faults, and plan and schedule shuttle operations activities. These applications are being developed independently of one another, using different representation schemes, reasoning and control models, and hardware platforms. KSC has recently initiated the EXODUS project to integrate these stand alone applications into a unified, coordinated intelligent operations support system. EXODUS will be constructed using SOCIAL, a tool for developing distributed intelligent systems. EXODUS, SOCIAL, and initial prototyping efforts using SOCIAL to integrate and coordinate selected EXODUS applications are described.

  2. Web system to support analysis of the Tile Calorimeter commissioning

    Science.gov (United States)

    Maidantchik, C.; Faria, A.; Grael, F. F.; Ferreira, F. G.; Galvão, K. K.; Dotti, A.; Solans, C.; Price, L.

    2008-07-01

    This article describes the set of computer systems that support the data analysis and quality control during the Tile Calorimeter commissioning phase. The Tile Commissioning Web System (TCWS) encapsulates the steps to retrieve information, execute programs, access the outcomes, register statements and verify the equipment status. TCWS integrates different applications, each one presenting a particular view of the commissioning process. The TileComm Analysis stores plots and analysis results, provides equipment-oriented visualization, collects information regarding the equipment performance, and outlines its status in each test. The Timeline application provides the equipment status history in a chronological way. The Web Interface for Shifters supports monitoring tasks by managing test parameters, graphical views of the detector's performance, and information status of all equipment that was used in each test. The DCS Web System provides a standard way to verify the behaviour of power sources and the cooling system.

  3. [Knowledge management system for laboratory work and clinical decision support].

    Science.gov (United States)

    Inada, Masanori; Sato, Mayumi; Yoneyama, Akiko

    2011-05-01

    This paper discusses a knowledge management system for clinical laboratories. In the clinical laboratory of Toranomon Hospital, we receive about 20 questions relevant to laboratory tests per day from medical doctors or co-medical staff. These questions mostly involve the essence to appropriately accomplish laboratory tests. We have to answer them carefully and suitably because an incorrect answer may cause a medical accident. Up to now, no method has been in place to achieve a rapid response and standardized answers. For this reason, the laboratory staff have responded to various questions based on their individual knowledge. We began to develop a knowledge management system to promote the knowledge of staff working for the laboratory. This system is a type of knowledge base for assisting the work, such as inquiry management, laboratory consultation, process management, and clinical support. It consists of several functions: guiding laboratory test information, managing inquiries from medical staff, reporting results of patient consultation, distributing laboratory staffs notes, and recording guidelines for laboratory medicine. The laboratory test information guide has 2,000 records of medical test information registered in the database with flexible retrieval. The inquiry management tool provides a methos to record all questions, answer easily, and retrieve cases. It helps staff to respond appropriately in a short period of time. The consulting report system treats patients' claims regarding medical tests. The laboratory staffs notes enter a file management system so they can be accessed to aid in clinical support. Knowledge sharing using this function can achieve the transition from individual to organizational learning. Storing guidelines for laboratory medicine will support EBM. Finally, it is expected that this system will support intellectual activity concerning laboratory work and contribute to the practice of knowledge management for clinical work support.

  4. Advanced physical-chemical life support systems research

    Science.gov (United States)

    Evanich, Peggy L.

    1988-01-01

    A proposed NASA space research and technology development program will provide adequate data for designing closed loop life support systems for long-duration manned space missions. This program, referred to as the Pathfinder Physical-Chemical Closed Loop Life Support Program, is to identify and develop critical chemical engineering technologies for the closure of air and water loops within the spacecraft, surface habitats or mobility devices. Computerized simulation can be used both as a research and management tool. Validated models will guide the selection of the best known applicable processes and in the development of new processes. For the integration of the habitat system, a biological subsystem would be introduced to provide food production and to enhance the physical-chemical life support functions on an ever-increasing basis.

  5. Plants for space plantations. [crops for closed life support systems

    Science.gov (United States)

    Nikishanova, T. I.

    1978-01-01

    Criteria for selection of candidate crops for closed life support systems are presented and discussed, and desired characteristics of candidate higher plant crops are given. Carbohydrate crops, which are most suitable, grown worldwide are listed and discussed. The sweet potato, ipomoea batatas Poir., is shown to meet the criteria to the greatest degree, and the criteria are recommended as suitable for initial evaluation of candidate higher plant crops for such systems.

  6. Supporting requirements model evolution throughout the system life-cycle

    OpenAIRE

    Ernst, Neil; Mylopoulos, John; Yu, Yijun; Ngyuen, Tien T.

    2008-01-01

    Requirements models are essential not just during system implementation, but also to manage system changes post-implementation. Such models should be supported by a requirements model management framework that allows users to create, manage and evolve models of domains, requirements, code and other design-time artifacts along with traceability links between their elements. We propose a comprehensive framework which delineates the operations and elements necessary, and then describe a tool imp...

  7. Phase Change Permeation Technology For Environmental Control Life Support Systems

    Science.gov (United States)

    Wheeler, Raymond M.

    2014-01-01

    Use of a phase change permeation membrane (Dutyion [Trademark]) to passively and selectively mobilize water in microgravity to enable improved water recovery from urine/brine for Environment Control and Life Support Systems (ECLSS) and water delivery to plans for potential use in microgravity.

  8. Sino-European Cooperation in Flood Analysis Support System

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ Flaced with imminent floods, what should decision-makers do first: evacuate the population,reinforce or intentionally break dikes? A support decision system developed by an international team of researchers will help them to make appropriate decisions to limit flood damage.

  9. Advanced Modular Power Approach to Affordable, Supportable Space Systems

    Science.gov (United States)

    Oeftering, Richard C.; Kimnach, Greg L.; Fincannon, James; Mckissock,, Barbara I.; Loyselle, Patricia L.; Wong, Edmond

    2013-01-01

    Recent studies of missions to the Moon, Mars and Near Earth Asteroids (NEA) indicate that these missions often involve several distinct separately launched vehicles that must ultimately be integrated together in-flight and operate as one unit. Therefore, it is important to see these vehicles as elements of a larger segmented spacecraft rather than separate spacecraft flying in formation. The evolution of large multi-vehicle exploration architecture creates the need (and opportunity) to establish a global power architecture that is common across all vehicles. The Advanced Exploration Systems (AES) Modular Power System (AMPS) project managed by NASA Glenn Research Center (GRC) is aimed at establishing the modular power system architecture that will enable power systems to be built from a common set of modular building blocks. The project is developing, demonstrating and evaluating key modular power technologies that are expected to minimize non-recurring development costs, reduce recurring integration costs, as well as, mission operational and support costs. Further, modular power is expected to enhance mission flexibility, vehicle reliability, scalability and overall mission supportability. The AMPS project not only supports multi-vehicle architectures but should enable multi-mission capability as well. The AMPS technology development involves near term demonstrations involving developmental prototype vehicles and field demonstrations. These operational demonstrations not only serve as a means of evaluating modular technology but also provide feedback to developers that assure that they progress toward truly flexible and operationally supportable modular power architecture.

  10. A Decision Support System for Solving Multiple Criteria Optimization Problems

    Science.gov (United States)

    Filatovas, Ernestas; Kurasova, Olga

    2011-01-01

    In this paper, multiple criteria optimization has been investigated. A new decision support system (DSS) has been developed for interactive solving of multiple criteria optimization problems (MOPs). The weighted-sum (WS) approach is implemented to solve the MOPs. The MOPs are solved by selecting different weight coefficient values for the criteria…

  11. Supporting Social Interaction in Intelligent Competence Development Systems

    NARCIS (Netherlands)

    Sereno, Bertrand; Boursinou, Eleni; Maxwell, Katrina; Angehrn, Albert

    2007-01-01

    Sereno, B., Boursinou, E., Maxwell, K., & Angehrn, A. A. (2007). Supporting Social Interaction in Intelligent Competence Development Systems. In D. Griffiths, R. Koper & O. Liber (Eds.), Proceedings of the 2nd TENCompetence Open Workshop (pp. 29-35). January, 11-12, 2007, Manchester, United Kingdom.

  12. ADDIS: A decision support system for evidence-based medicine

    NARCIS (Netherlands)

    G. van Valkenhoef (Gert); T. Tervonen (Tommi); T. Zwinkels (Tijs); B. de Brock (Bert); H.L. Hillege (Hans)

    2013-01-01

    textabstractClinical trials are the main source of information for the efficacy and safety evaluation of medical treatments. Although they are of pivotal importance in evidence-based medicine, there is a lack of usable information systems providing data-analysis and decision support capabilities for

  13. Marketing Management Support Systems: evolution, adoption and effectiveness

    NARCIS (Netherlands)

    B. Wierenga (Berend); G.H. van Bruggen (Gerrit)

    1995-01-01

    textabstractA Marketing Management Support Systems can be defined as any device combining (i) information technology, (ii) marketing data and/ or knowledge, and (iii) analytical capabilities, made available to one or more marketing decision-makers with the objective to improve the quality of marketi

  14. Management Control System Support of Initiatives for Disruptive Students

    Science.gov (United States)

    Scott, Colin

    2011-01-01

    Purpose: The purpose of the paper is to investigate the management control system (MCS) support of school initiatives to develop the school climate and to re-engage disruptive students. Design/methodology/approach: The paper adopts an approach of critical action research interviews with management and document reviews informed by Habermasian…

  15. Intellectual Disability: Definition, Classification, and Systems of Supports. Eleventh Edition

    Science.gov (United States)

    Schalock, Robert L.; Borthwick-Duffy, Sharon A.; Bradley, Valerie J.; Buntinx, Wil H. E.; Coulter, David L.; Craig, Ellis M.; Gomez, Sharon C.; Lachapelle, Yves; Luckasson, Ruth; Reeve, Alya; Shogren, Karrie A.; Snell, Martha E.; Spreat, Scott; Tasse, Marc J.; Thompson, James R.; Verdugo-Alonso, Miguel A.; Wehmeyer, Michael L.; Yeager, Mark H.

    2010-01-01

    This Manual contains the most current and authoritative information and knowledge on intellectual disability, including best practice guidelines on diagnosing and classifying intellectual disability and developing a system of supports for people living with an intellectual disability. Written by a committee of 18 experts, "Intellectual…

  16. Decision support system for treatment of dredged sediments

    NARCIS (Netherlands)

    Joziasse, J.; Bakker, T.; Eggels, P.G.

    1998-01-01

    A decision support system for treatment of dredged sediments (DSTS) has been constructed, in which the environmental effects of various treatment options applied can be compared. The effects are evaluated by scores on environmental themes like global warming and acidification, using life cycle asses

  17. Decision Support System for Optimized Herbicide Dose in Spring Barley

    DEFF Research Database (Denmark)

    Sønderskov, Mette; Kudsk, Per; Mathiassen, Solvejg K;

    2014-01-01

    Crop Protection Online (CPO) is a decision support system, which integrates decision algorithms quantifying the requirement for weed control and a herbicide dose model. CPO was designed to be used by advisors and farmers to optimize the choice of herbicide and dose. The recommendations from CPO...

  18. Astronaut Jack Lousma with part of Inflight Medical Support System

    Science.gov (United States)

    1973-01-01

    Astronaut Jack R. Lousma, Skylab 3 pilot, reaches into a medical kit, part of the Inflight Medical Support System (IMSS), during training for the second manned Skylab Earth-orbital mission. This activity took place in the Orbital Workshop (OWS) trainer in the Mission Simulation and Training Facility at JSC.

  19. Decision support for information systems management : applying analytic hierarchy process

    NARCIS (Netherlands)

    Huizingh, Eelko K.R.E.; Vrolijk, Hans C.J.

    1995-01-01

    Decision-making in the field of information systems has become more complex due to a larger number of alternatives, multiple and sometimes conflicting goals, and an increasingly turbulent environment. In this paper we explore the appropriateness of Analytic Hierarchy Process to support I/S decision

  20. Service-Oriented Architecture Approach to MAGTF Logistics Support Systems

    Science.gov (United States)

    2013-09-01

    me her unconditional love and support throughout my tenure at NPS as well as the past 17 years of my Marine Corps career . Her unselfish sacrifice and... indecisiveness the inability to effectively perform LCM systems integration will continue to trouble the Marine Corps. In order to meaningfully

  1. A Cooperative Intelligent Decision Support System for Contingency Management

    Directory of Open Access Journals (Sweden)

    Abdelkader ADLA

    2006-01-01

    Full Text Available Traditional Decision Support Systems (DSS give not enough possibilities of intervention to the user. These systems are reduced to an insular and very technical state in which the objective is not support decision but to dump data on the screen in the hope that the user will know what to do with. In complex situations, decision is not structured and it becomes primordial to design intelligent and cooperative systems allowing a joint resolution of problem based on dynamic sharing of the tasks between the user and the system and according to problems to be solved. In this perspective, we propose a cooperative architecture for intelligent decision support system. The framework embeds expert knowledge within the DSS to provide intelligent DSS using collaboration technologies by putting the decision maker effectively in the loop of the decision process. To this end, we used a structure based on domain and task conceptual modelling. Applicability and relevance of this model are illustrated through a case study where the system and the operator cooperate in decision problem which consists of identifying boiler defects, diagnosing and suggesting actions of cure.

  2. Development of Life Support System Technologies for Human Lunar Missions

    Science.gov (United States)

    Barta, Daniel J.; Ewert, Michael K.

    2009-01-01

    With the Preliminary Design Review (PDR) for the Orion Crew Exploration Vehicle planned to be completed in 2009, Exploration Life Support (ELS), a technology development project under the National Aeronautics and Space Administration s (NASA) Exploration Technology Development Program, is focusing its efforts on needs for human lunar missions. The ELS Project s goal is to develop and mature a suite of Environmental Control and Life Support System (ECLSS) technologies for potential use on human spacecraft under development in support of U.S. Space Exploration Policy. ELS technology development is directed at three major vehicle projects within NASA s Constellation Program (CxP): the Orion Crew Exploration Vehicle (CEV), the Altair Lunar Lander and Lunar Surface Systems, including habitats and pressurized rovers. The ELS Project includes four technical elements: Atmosphere Revitalization Systems, Water Recovery Systems, Waste Management Systems and Habitation Engineering, and two cross cutting elements, Systems Integration, Modeling and Analysis, and Validation and Testing. This paper will provide an overview of the ELS Project, connectivity with its customers and an update to content within its technology development portfolio with focus on human lunar missions.

  3. Supporting health systems in Europe: added value of EU actions?

    Science.gov (United States)

    Clemens, Timo; Michelsen, Kai; Brand, Helmut

    2014-01-01

    Since the start of the economic crisis, the European Union's (EU's) predominant discourse has been austerity and fiscal consolidation. The detrimental effects on Europe's health systems and the health status of its citizens are well described. However, little is known about the emerging EU-level initiatives to support national health systems handle the challenges of efficient care provision and system reorganisation aimed to meet their future needs. This review analyses the manner, conditions and prospects of such EU support. First, health system objectives are increasingly entering the EU health policy agenda. Second, professional and patient mobility provisions may support member states (MS) in copying with crisis related health challenges but can potentially acerbate them at the same time. Third, in recent initiatives health system goals are more closely tied to the EU's economic growth narrative. And fourth, health system issues are taken up in existing EU-level structures for debate and exchange between MS. In addition, the design of some policies may have the potential to intensify socioeconomic and health inequalities rather than ameliorate them.

  4. Support afferentation in the posture and locomotion control system

    Science.gov (United States)

    Grigoriev, Anatoly; Tomilovskaya, Elena; Kozlovskaya, Inesa

    Mechanisms of support afferentation contribution in posture and locomotion control, which were uncertain up to now, became the point of intensive studies recently. This became possible since the space flights era started which created the conditions for simulated microgravity experiments under conditions of dry immersion and bedrest. The results of neurophysiological studies performed under the conditions of supportlessness have shown that decline or elimination of support loads is followed by deep and fast developing alterations in postural tonic system, including development of postural muscle atonia, changes of recruitment order of motoneurons innervating the shin muscles, spinal hyperreflexia development etc. (Kozlovskaya I.B. et al., 1987). It has been also shown that application of artificial support stimulation in the regimen of natural locomotion under these conditions decreases significantly or even eliminates the development of mentioned changes. The results of these studies laid down the basis for a new hypothesis on the trigger role of support afferentation in postural tonic system and its role in organization and control of postural synergies (Grigoriev A.I. et al., 2004). According to this hypothesis the muscle reception is considered to be the leading afferent input in the control of locomotion. However the data of recent studies pointed out strongly to the participation of support afferentation in definition of cognitive strategies and motor programs of locomotor movements (Chernikova L.A. et al., 2013) and, consequently, in the processes of their initiation (Gerasimenko Yu.P. et al., 2012). The cortical locomotor reflex composes apparently the basis of these processes. The receptive field of this reflex is located in the support zones of the soles and the central part is located in the posterior parietal areas (IPL) of brain cortex. The study is supported by RFBR grant N 13-04-12091 OFI-m.

  5. The Aegean Sea marine security decision support system

    Directory of Open Access Journals (Sweden)

    L. Perivoliotis

    2011-05-01

    Full Text Available As part of the integrated ECOOP (European Coastal Sea Operational observing and Forecasting System project, HCMR upgraded the already existing standalone Oil Spill Forecasting System for the Aegean Sea, initially developed for the Greek Operational Oceanography System (POSEIDON, into an active element of the European Decision Support System (EuroDeSS. The system is accessible through a user friendly web interface where the case scenarios can be fed into the oil spill drift model component, while the synthetic output contains detailed information about the distribution of oil spill particles and the oil spill budget and it is provided both in text based ECOOP common output format and as a series of sequential graphics. The main development steps that were necessary for this transition were the modification of the forcing input data module in order to allow the import of other system products which are usually provided in standard formats such as NetCDF and the transformation of the model's calculation routines to allow use of current, density and diffusivities data in z instead of sigma coordinates. During the implementation of the Aegean DeSS, the system was used in operational mode in order support the Greek marine authorities in handling a real accident that took place in North Aegean area. Furthermore, the introduction of common input and output files by all the partners of EuroDeSS extended the system's interoperability thus facilitating data exchanges and comparison experiments.

  6. The Aegean sea marine security decision support system

    Directory of Open Access Journals (Sweden)

    L. Perivoliotis

    2011-10-01

    Full Text Available As part of the integrated ECOOP (European Coastal Sea Operational observing and Forecasting System project, HCMR upgraded the already existing standalone Oil Spill Forecasting System for the Aegean Sea, initially developed for the Greek Operational Oceanography System (POSEIDON, into an active element of the European Decision Support System (EuroDeSS. The system is accessible through a user friendly web interface where the case scenarios can be fed into the oil spill drift model component, while the synthetic output contains detailed information about the distribution of oil spill particles and the oil spill budget and it is provided both in text based ECOOP common output format and as a series of sequential graphics. The main development steps that were necessary for this transition were the modification of the forcing input data module in order to allow the import of other system products which are usually provided in standard formats such as NetCDF and the transformation of the model's calculation routines to allow use of current, density and diffusivities data in z instead of sigma coordinates. During the implementation of the Aegean DeSS, the system was used in operational mode in order to support the Greek marine authorities in handling a real accident that took place in North Aegean area. Furthermore, the introduction of common input and output files by all the partners of EuroDeSS extended the system's interoperability thus facilitating data exchanges and comparison experiments.

  7. Effects of 12 days exposure to simulated microgravity on central circulatory hemodynamics in the rhesus monkey

    Science.gov (United States)

    Convertino, V. A.; Koenig, S. C.; Krotov, V. P.; Fanton, J. W.; Korolkov, V. I.; Trambovetsky, E. V.; Ewert, D. L.; Truzhennikov, A.; Latham, R. D.

    1998-01-01

    Central circulatory hemodynamic responses were measured before and during the initial 9 days of a 12-day 10 degrees head-down tilt (HDT) in 4 flight-sized juvenile rhesus monkeys who were surgically instrumented with a variety of intrathoracic catheters and blood flow sensors to assess the effects of simulated microgravity on central circulatory hemodynamics. Each subject underwent measurements of aortic and left ventricular pressures, and aortic flow before and during HDT as well as during a passive head-up postural test before and after HDT. Heart rate, stroke volume, cardiac output, and left ventricular end-diastolic pressure were measured, and dP/dt and left ventricular elastance was calculated from hemodynamic measurements. The postural test consisted of 5 min of supine baseline control followed by 5 minutes of 90 degrees upright tilt (HUT). Heart rate, stroke volume, cardiac output, and left ventricular end-diastolic pressure showed no consistent alterations during HDT. Left ventricular elastance was reduced in all animals throughout HDT, indicating that cardiac compliance was increased. HDT did not consistently alter left ventricular +dP/dt, indicating no change in cardiac contractility. Heart rate during the post-HDT HUT postural test was elevated compared to pre-HDT while post-HDT cardiac output was decreased by 52% as a result of a 54% reduction in stroke volume throughout HUT. Results from this study using an instrumented rhesus monkey suggest that exposure to microgravity may increase ventricular compliance without alternating cardiac contractility. Our project supported the notion that an invasively-instrumented animal model should be viable for use in spaceflight cardiovascular experiments to assess potential changes in myocardial function and cardiac compliance.

  8. Decision Support Systems for Launch and Range Operations Using Jess

    Science.gov (United States)

    Thirumalainambi, Rajkumar

    2007-01-01

    The virtual test bed for launch and range operations developed at NASA Ames Research Center consists of various independent expert systems advising on weather effects, toxic gas dispersions and human health risk assessment during space-flight operations. An individual dedicated server supports each expert system and the master system gather information from the dedicated servers to support the launch decision-making process. Since the test bed is based on the web system, reducing network traffic and optimizing the knowledge base is critical to its success of real-time or near real-time operations. Jess, a fast rule engine and powerful scripting environment developed at Sandia National Laboratory has been adopted to build the expert systems providing robustness and scalability. Jess also supports XML representation of knowledge base with forward and backward chaining inference mechanism. Facts added - to working memory during run-time operations facilitates analyses of multiple scenarios. Knowledge base can be distributed with one inference engine performing the inference process. This paper discusses details of the knowledge base and inference engine using Jess for a launch and range virtual test bed.

  9. A decision support system for the reading of ancient documents

    DEFF Research Database (Denmark)

    Roued-Cunliffe, Henriette

    2011-01-01

    The research presented in this thesis is based in the Humanities discipline of Ancient History and begins by attempting to understand the interpretation process involved in reading ancient documents and how this process can be aided by computer systems such as Decision Support Systems (DSS...... this process in the five areas: remembering complex reasoning, searching huge datasets, international collaboration, publishing editions, and image enhancement. This research contains a large practical element involving the development of a DSS prototype. The prototype is used to illustrate how a DSS......). The thesis balances between the use of IT tools to aid Humanities research and the understanding that Humanities research must involve human beings. It does not attempt to develop a system that can automate the reading of ancient documents. Instead it seeks to demonstrate and develop tools that can support...

  10. Advanced intelligent computational technologies and decision support systems

    CERN Document Server

    Kountchev, Roumen

    2014-01-01

    This book offers a state of the art collection covering themes related to Advanced Intelligent Computational Technologies and Decision Support Systems which can be applied to fields like healthcare assisting the humans in solving problems. The book brings forward a wealth of ideas, algorithms and case studies in themes like: intelligent predictive diagnosis; intelligent analyzing of medical images; new format for coding of single and sequences of medical images; Medical Decision Support Systems; diagnosis of Down’s syndrome; computational perspectives for electronic fetal monitoring; efficient compression of CT Images; adaptive interpolation and halftoning for medical images; applications of artificial neural networks for real-life problems solving; present and perspectives for Electronic Healthcare Record Systems; adaptive approaches for noise reduction in sequences of CT images etc.

  11. Damping and support in high-temperature superconducting levitation systems

    Energy Technology Data Exchange (ETDEWEB)

    Hull, John R. (Sammamish, WA); McIver, Carl R. (Everett, WA); Mittleider, John A. (Kent, WA)

    2009-12-15

    Methods and apparatuses to provide improved auxiliary damping for superconducting bearings in superconducting levitation systems are disclosed. In a superconducting bearing, a cryostat housing the superconductors is connected to a ground state with a combination of a damping strip of material, a set of linkage arms to provide vertical support, and spring washers to provide stiffness. Alternately, the superconducting bearing may be supported by a cryostat connected to a ground state by posts constructed from a mesh of fibers, with the damping and stiffness controlled by the fiber composition, size, and mesh geometry.

  12. An Integrated Broadband Switching System with Narrowband Service Support

    Institute of Scientific and Technical Information of China (English)

    GONG Xiangyang; ZHANG Peng; CHENG Shiduan

    2001-01-01

    It is considered that ATM is not suitable for traditional narrowband services such as voice because of large adapting delay. In this paper,we present an ATM-based broadband switching system, which is capable of supporting narrowband services. A composite cell adapting method is adopted in this system to reduce adapting delay and guarantee QoS (Quality of Service). In the realized system, several key parameters have been measured. The results prove that it can guarantee perfect QoS and relative high bandwidth efficiency.

  13. [Information system for supporting the Nursing Care Systematization].

    Science.gov (United States)

    Malucelli, Andreia; Otemaier, Kelly Rafaela; Bonnet, Marcel; Cubas, Marcia Regina; Garcia, Telma Ribeiro

    2010-01-01

    It is an unquestionable fact, the importance, relevance and necessity of implementing the Nursing Care Systematization in the different environments of professional practice. Considering it as a principle, emerged the motivation for the development of an information system to support the Nursing Care Systematization, based on Nursing Process steps and Human Needs, using the diagnoses language, nursing interventions and outcomes for professional practice documentation. This paper describes the methodological steps and results of the information system development - requirements elicitation, modeling, object-relational mapping, implementation and system validation.

  14. Sizable variations in circulatory disease mortality by region and country of birth in six European countries

    DEFF Research Database (Denmark)

    Rafnsson, Snorri B; Bhopal, Raj S; Agyemang, Charles;

    2013-01-01

    . RESULTS: South Asians in Denmark, England and Wales and France experienced excess circulatory disease mortality (MRRs 1.37-1.91). Similar results were seen for Eastern Europeans in these countries as well as in Sweden (MRRs 1.05-1.51), for those of Middle Eastern origin in Denmark (MRR = 1.49) and France......BACKGROUND: Circulatory disease mortality inequalities by country of birth (COB) have been demonstrated for some EU countries but pan-European analyses are lacking. We examine inequalities in circulatory mortality by geographical region/COB for six EU countries. METHODS: We obtained national death...... sizes. The pattern for IHD mortality was similar to that for circulatory disease mortality. Two- to three-fold excess cerebrovascular disease mortality was found for several foreign-born groups compared with the local-born populations in some countries. CONCLUSIONS: Circulatory disease mortality varies...

  15. Construction of modular novel bioartificial liver support system.

    Science.gov (United States)

    Liu, Jianfeng; Song, Tao; Jiang, Wei; Zhang, Yimin; Lv, Guoliang; Zhao, Lifu; Zhang, Guanghao; Li, Lanjuan

    2009-01-01

    A modular novel bioartificial liver support system was designed and constructed in order to simplify tedious operation of artificial liver treatment and to improve the applicability in the system. The design ideas, structure composition, system function, and etc, were described in detail. In this system, the variety of the therapy modes could be conveniently connected by the interface of modular structure. Industrial control computer was used as the main control platform, and physical of control parameters such as pressure, pump speed, dissolved oxygen, temperature, and etc, were transmitted into computer, then according to the instruction, process of the treatment was accomplished by the executing units implemented by main control system. Touch screen of human-computer interface was adopted, which made the system better operational and more comfortable. The system has passed the spot function test, and all indexes can meet requirements for the clinical treatment requested. It has the character such as modular design, systematic distribution, building-block structure, and etc, which supports a great novel operation platform for artificial therapy.

  16. A cholinergic contribution to the circulatory responses evoked at the onset of handgrip exercise in humans

    DEFF Research Database (Denmark)

    Vianna, Lauro C; Fadel, Paul J; Secher, Niels H

    2015-01-01

    A cholinergic (muscarinic) contribution to the initial circulatory response to exercise in humans remains controversial. Herein, we posit that this may be due to exercise mode with a cholinergic contribution being important during isometric handgrip exercise, where the hyperemic response...... of the muscle is relatively small compared with the onset of leg cycling, where a marked increase in muscle blood flow rapidly occurs as a consequence of multiple redundant mechanisms. We recorded blood pressure (BP; brachial artery), stroke volume (pulse contour analysis), cardiac output, and systemic vascular...... resistance (SVR) in young healthy males, while performing either 20 s of isometric handgrip contraction at 40% maximum voluntary contraction (protocol 1; n = 9) or 20 s of low-intensity leg cycling exercise (protocol 2; n = 8, 42 ± 8 W). Exercise trials were conducted under control (no drug) conditions...

  17. Developing the US Wildland Fire Decision Support System

    Directory of Open Access Journals (Sweden)

    Erin K. Noonan-Wright

    2011-01-01

    Full Text Available A new decision support tool, the Wildland Fire Decision Support System (WFDSS has been developed to support risk-informed decision-making for individual fires in the United States. WFDSS accesses national weather data and forecasts, fire behavior prediction, economic assessment, smoke management assessment, and landscape databases to efficiently formulate and apply information to the decision making process. Risk-informed decision-making is becoming increasingly important as a means of improving fire management and offers substantial opportunities to benefit natural and community resource protection, management response effectiveness, firefighter resource use and exposure, and, possibly, suppression costs. This paper reviews the development, structure, and function of WFDSS, and how it contributes to increased flexibility and agility in decision making, leading to improved fire management program effectiveness.

  18. A Group Creativity Support System for Dynamic Idea Evaluation

    DEFF Research Database (Denmark)

    Ulrich, Frank

    2015-01-01

    Idea evaluation is necessary in most modern organizations to identify the level of novelty and usefulness of new ideas. However, current idea evaluation research hinders creativity by primarily supporting convergent thinking (narrowing down ideas to a few tangible solutions), while divergent...... thinking (the development of wildly creative and novel thoughts patterns) is discounted. In this paper, this current view of idea evaluation is challenged through the development of a prototype that supports dynamic idea evaluation. The prototype uses knowledge created during evaluative processes...... to facilitate divergent thinking in a Group Creativity Support System (GCSS) designed from state-of-the-art research. The prototype is interpretively explored through a field experiment in a Danish IS research department. Consequently, the prototype demonstrates the ability to including divergent thinking...

  19. Decision Support Systems (DSS) in Construction Tendering Processes

    CERN Document Server

    Mohemad, Rosmayati; Othman, Zulaiha Ali; Noor, Noor Maizura Mohamad

    2010-01-01

    The successful execution of a construction project is heavily impacted by making the right decision during tendering processes. Managing tender procedures is very complex and uncertain involving coordination of many tasks and individuals with different priorities and objectives. Bias and inconsistent decision are inevitable if the decision-making process is totally depends on intuition, subjective judgement or emotion. In making transparent decision and healthy competition tendering, there exists a need for flexible guidance tool for decision support. Aim of this paper is to give a review on current practices of Decision Support Systems (DSS) technology in construction tendering processes. Current practices of general tendering processes as applied to the most countries in different regions such as United States, Europe, Middle East and Asia are comprehensively discussed. Applications of Web-based tendering processes is also summarised in terms of its properties. Besides that, a summary of Decision Support Sy...

  20. Neuro computing in knowledge-based decision support systems

    Energy Technology Data Exchange (ETDEWEB)

    Sirola, Miki; Lampi, Golan; Parviainen, Jukka

    2004-07-01

    Knowledge-based decision support systems of today are due to development of many decades. More and more methodologies and application areas have been involved during this time. In this paper neural methods are combined with knowledge-based methodologies. Self-Organizing Map (SOM) is used together with rule-based reasoning, and realized in a prototype of a decision support system. This system, which can be used e.g. in fault diagnosis, is based on an earlier study including compatibility analysis. A Matlab-based tool is capable of doing tasks in fault detection and identification. We show with an example how SOM analysis can help decision making in a computerized decision support system. Quantisation error between normal data and error data is one important methodological tool in this analysis. This kind of decision making is needed for instance in control room in state monitoring of a safety critical process in industry. A scenario about a leak in the primary circuit of a BWR nuclear power plant is also shortly demonstrated. (Author)

  1. The Coordinated Scheduling Support System of Production and Delivery

    Directory of Open Access Journals (Sweden)

    Ming-Feng Yang

    2009-01-01

    Full Text Available Problem statement: Traditional scheduling models which only address the sequence of jobs to be processed at the production stage under some criteria are no longer suitable and should be extended to cope with the distribution stage after production. In a rapidly changing environment, competition among enterprises has a tendency to turn towards competing between supply chain systems instead of competing between individual companies. Emphasizing on the coordination and the integration among various members of a supply chain has become one of the vital strategies for the modern manufacturers to gain competitive advantages. Approach: This research focuses mainly on a class of two-stage scheduling problem, in which jobs need to be delivered to customers by vehicles after the completion of their respective production. It is assumed that the transportation time of a vehicle is constant and jobs to be delivered occupy different physical spaces. Results: The result of this research is to show the scheduling problem with the objective of minimizing total completion time is intractable and to develop a heuristic by incorporating properties inherited in an the optimal schedule. In addition, we take a Decision Support System (DSS view to construct a Scheduling Support System (SSS for solving the scheduling problem with delivery coordination. Conclusion/Recommendations: The scheduling support system with an additional problem management subsystem can provide more useful information for users when the management makes a strategic decision than traditional scheduling methods can. It can give firms a competitive advantage on the global competitive market.

  2. Robust support vector machine-trained fuzzy system.

    Science.gov (United States)

    Forghani, Yahya; Yazdi, Hadi Sadoghi

    2014-02-01

    Because the SVM (support vector machine) classifies data with the widest symmetric margin to decrease the probability of the test error, modern fuzzy systems use SVM to tune the parameters of fuzzy if-then rules. But, solving the SVM model is time-consuming. To overcome this disadvantage, we propose a rapid method to solve the robust SVM model and use it to tune the parameters of fuzzy if-then rules. The robust SVM is an extension of SVM for interval-valued data classification. We compare our proposed method with SVM, robust SVM, ISVM-FC (incremental support vector machine-trained fuzzy classifier), BSVM-FC (batch support vector machine-trained fuzzy classifier), SOTFN-SV (a self-organizing TS-type fuzzy network with support vector learning) and SCLSE (a TS-type fuzzy system with subtractive clustering for antecedent parameter tuning and LSE for consequent parameter tuning) by using some real datasets. According to experimental results, the use of proposed approach leads to very low training and testing time with good misclassification rate.

  3. Crop candidates for the bioregenerative life support systems in China

    Science.gov (United States)

    Chunxiao, Xu; Hong, Liu

    The use of plants for life support applications in space is appealing because of the multiple life support functions by the plants. Research on crops that were grown in the life support system to provide food and oxygen, remove carbon dioxide was begun from 1960. To select possible crops for research on the bioregenerative life support systems in China, criteria for the selection of potential crops were made, and selection of crops was carried out based on these criteria. The results showed that 14 crops including 4 food crops (wheat, rice, soybean and peanut) and 7 vegetables (Chinese cabbage, lettuce, radish, carrot, tomato, squash and pepper) won higher scores. Wheat ( Triticum aestivum L.), rice ( Oryza sativa L.), soybean ( Glycine max L.) and peanut ( Arachis hypogaea L.) are main food crops in China. Chinese cabbage ( Brassica campestris L. ssp. chinensis var. communis), lettuce ( Lactuca sativa L. var. longifolia Lam.), radish ( Raphanus sativus L.), carrot ( Daucus carota L. var. sativa DC.), tomato ( Lycopersicon escalentum L.), squash ( Cucurbita moschata Duch.) and pepper ( Capsicum frutescens L. var. longum Bailey) are 7 vegetables preferred by Chinese. Furthermore, coriander ( Coriandum sativum L.), welsh onion ( Allium fistulosum L. var. giganteum Makino) and garlic ( Allium sativum L.) were selected as condiments to improve the taste of space crew. To each crop species, several cultivars were selected for further research according to their agronomic characteristics.

  4. Clinical Decision Support Systems: A Useful Tool in Clinical Practice

    Directory of Open Access Journals (Sweden)

    Kolostoumpis G.

    2012-01-01

    Full Text Available The possibility of supporting in decision – making shows an increase in recent years. Based on mathematic simulation tools, knowledge databases, processing methods, medical data and methods, artificial intelligence for coding of the available knowledge and for resolving complex problems arising into clinical practice. Aim: the aim of this review is to present the development of new methods and modern services, in clinical practice and the emergence in their implementation. Data and methods: the methodology that was followed included research of articles that referred to health sector and modern technologies, at the electronic data bases “pubmed” and “medline”. Results: Is a useful tool for medical experts using characteristics and medical data used by the doctors. Constitute innovation for the medical community, and ensure the support of clinical decisions with an overall way by providing a comprehensive solution in the light of the integration of computational decision support systems into clinical practice. Conclusions: Decision Support Systems contribute to improving the quality of health services with simultaneous impoundment of costs (i.e. avoid medical errors

  5. Review of Energy Storage System for Wind Power Integration Support

    DEFF Research Database (Denmark)

    Zhao, Haoran; Wu, Qiuwei; Hu, Shuju

    2015-01-01

    -discharging characteristics, Energy Storage System (ESS) is considered as an effective tool to enhance the flexibility and controllability not only of a specific wind farm, but also of the entire grid. This paper reviews the state of the art of the ESS technologies for wind power integration support from different aspects....... Firstly, the modern ESS technologies and their potential applications for wind power integration support are introduced. Secondly, the planning problem in relation to the ESS application for wind power integration is reviewed, including the selection of the ESS type, and the optimal sizing and siting......With the rapid growth of wind energy development and increasing wind power penetration level, it will be a big challenge to operate the power system with high wind power penetration securely and reliably due to the inherent variability and uncertainty of wind power. With the flexible charging...

  6. Process Planning Support System for Green Manufacturing and its application

    Institute of Scientific and Technical Information of China (English)

    HE Yan; LIU Fei; CAO Huajun; ZHANG Hua

    2007-01-01

    Owing to a lack of practical methods and soft- ware tools in the existing researches on green manufacturing (GM), process planning support system for green manufac- turing (GMPPSS) was developed to deal with the problems in optimization of environment-benign process planning. The GMPPSS consisted mainly of three function modules and related model repositories including: selection of process elements, optimization of process courses, and evaluation of process projects for GM. The database of the GMPPSS was used to provide plentiful information on resources consump- tion and environmental impact in manufacturing processes, which consisted of process attribute database, inventory database, machine database, tool database, and the cutting fluid database. Raw materials, secondary material consump- tion, energy consumption, and environment impacts of pro- cess planning were optimized to improve the green attribute of process planning of parts with the supports of the data- bases and model repositories. The gear processing in the machining tool factory was presented to verify the system's applicability.

  7. Deep hypothermic circulatory arrest: real-life suspended animation.

    Science.gov (United States)

    Chau, Katherine H; Ziganshin, Bulat A; Elefteriades, John A

    2013-01-01

    Deep hypothermic circulatory arrest (DHCA) is a cerebral protection technique that was developed in the 1950s and popularized in the 1970s. It has become one of the three most common cerebral protection techniques currently used in aortic arch surgeries, with the other two being antegrade cerebral perfusion (ACP) and retrograde cerebral perfusion (RCP). At our institution, DHCA has been the cerebral protection technique of choice for over a quarter century. Our clinical experience with DHCA has been very positive, and our clinical studies have shown DHCA to have outcomes equal to (and sometimes better than) those of ACP and RCP, and DHCA to be very effective at preserving neurocognitive function. Other institutions, however, prefer ACP or RCP to DHCA. Each technique has its own set of pros and cons, and the question regarding which technique is the superior method for cerebral protection is hotly debated.

  8. Support system for the W7-X coil assembly

    Energy Technology Data Exchange (ETDEWEB)

    Jaksic, N.; Simon-Weidner, J.; Sapper, J. [Max-Planck-Institut fuer Plasmaphysik, Garching (Germany)

    1998-07-01

    The WENDELSTEIN 7-X (W7-X) stellarator experiment is now in the state of its final design. The basic confinement system consists of 50 nonplanar and 20 planar superconducting coils. Meanwhile the geometrical data of the coils have been fixed. The changes with respect to the first design influenced the support concept taking into account needs on enlarged space for the different ports and nozzles. (author)

  9. Inverse Learning Control of Nonlinear Systems Using Support Vector Machines

    Institute of Scientific and Technical Information of China (English)

    HU Zhong-hui; LI Yuan-gui; CAI Yun-ze; XU Xiao-ming

    2005-01-01

    An inverse learning control scheme using the support vector machine (SVM) for regression was proposed. The inverse learning approach is originally researched in the neural networks. Compared with neural networks, SVMs overcome the problems of local minimum and curse of dimensionality. Additionally, the good generalization performance of SVMs increases the robustness of control system. The method of designing SVM inverselearning controller was presented. The proposed method is demonstrated on tracking problems and the performance is satisfactory.

  10. Innovative Navigation Systems to Support Digital Geophysical Mapping

    Science.gov (United States)

    2006-02-17

    Treated No intrusive activities were undertaken nor any material handled. 3.6.4. Residuals Handling This section is not applicable. 3.6.5...The four Cs- vapour sensors were equally separated by 40cm and supported on a non-metallic frame, as shown on the right side of the photograph in Figure...acquisition system showing the four Cs vapour magnetometer sensors at the front of the array (right of photo) and the reflective prism (red cube

  11. Space system operations and support cost analysis using Markov chains

    Science.gov (United States)

    Unal, Resit; Dean, Edwin B.; Moore, Arlene A.; Fairbairn, Robert E.

    1990-01-01

    This paper evaluates the use of Markov chain process in probabilistic life cycle cost analysis and suggests further uses of the process as a design aid tool. A methodology is developed for estimating operations and support cost and expected life for reusable space transportation systems. Application of the methodology is demonstrated for the case of a hypothetical space transportation vehicle. A sensitivity analysis is carried out to explore the effects of uncertainty in key model inputs.

  12. The Experiences of Using a Computerized Decision Support System

    Science.gov (United States)

    Fossum, Mariann; Ehnfors, Margareta; Fruhling, Ann; Ehrenberg, Anna

    2012-01-01

    The aim was to describe the facilitators and barriers influencing the ability of nursing personnel to effectively use a CDSS for planning and treating pressure ulcers and malnutrition in nursing homes. Usability evaluations and group interviews were conducted. Facilitators were ease of use, usefulness and a supportive work environment. Lack of training, resistance to using computers and limited integration of the CDSS with the electronic health record system were reported. PMID:24199144

  13. Decision support for information systems management: applying analytic hierarchy process

    OpenAIRE

    Huizingh, Eelko K.R.E.; Vrolijk, Hans C.J.

    1995-01-01

    Decision-making in the field of information systems has become more complex due to a larger number of alternatives, multiple and sometimes conflicting goals, and an increasingly turbulent environment. In this paper we explore the appropriateness of Analytic Hierarchy Process to support I/S decision making. AHP can be applied if the decision problem includes multiple objectives, conflicting criteria, incommensurable units, and aims at selecting an alternative from a known set of alternatives. ...

  14. Summary of Propulsion System Needs in Support of Project Constellation

    Science.gov (United States)

    Sumrall, Phil; Lorier, Terry; Baine, Michael

    2008-01-01

    In January 2004, the President of the United States established the Vision for Space Exploration (VSE) to return man to the moon and ultimately to extend manned space travel to Mars. This paper will summarize the manned space flight liquid propulsion system needs in support of Project Constellation over the next 10 years. It will include all engine needs to return man to the moon. An overview of engines currently under contract, those baselined but not yet under contract, and those engine needs that hav.e yet to be initiated. Project Constellation includes the components as shown Figure 1. Liquid propulsion systems supporting the manned portion of these elements include the following: the Crew Exploration Vehicle named Orion (crew module reaction control system (CMRCS), service module Orion Main Engine (OME), service module auxiliary RCS, and service module reaction control system (SMRCS)), the Crew Launch Vehicle named Ares 1 (J2X upper stage, first stage roll control system, second stage reaction control system, and the Ares I-X roll control system), the Heavy Lift Launch Vehicle named Ares V (RS68B first stage booster, J-2X upper stage, roll control systems, and the Earth Departure Stage (EDS) (powered by the same Ares V Upper Stage J-2X), and the Lunar Lander named Altair with both descent and ascent stages (lunar orbit insertion and descent main engine, ascent main engine, and attitude control systems for both stages). In addition, there may be additional engine needs for early demonstrators, but those will not be speculated on as part of this paper. Also, other portions of the VSE architecture, including the planned Orion abort demonstrations and the Lunar Precursor Robotic Program, are not addressed here as they either use solid motors or are focused on unmanned precursor missions.

  15. Recent developments associated with decision support systems in water resources

    Science.gov (United States)

    Watkins, David W.; McKinney, Daene C.

    1995-07-01

    In order to limit the scope of this review, a working definition of a decision support system is needed. L. Adelman has defined decision support systems (DSSs) as "interactive computer programs that utilize analytical methods, such as decision analysis, optimization algorithms, program scheduling routines, and so on, for developing models to help decision makers formulate alternatives, analyze their impacts, and interpret and select appropriate options for implementation" (Adelman [1992], p. 2). Another definition has been offered by S. J. Andriole, who defined decision support as consisting of "any and all data, information, expertise or activities that contribute to option selection" (Andriole [1989], p. 3). A common idea explicit in each of these definitions is that DSSs integrate various technologies and aid in option selection. Implicit in each definition is that these are options for solving relatively large, unstructured problems. Thus, the following working definition of a DSS will be used in this review: A DSS is an integrated, interactive computer system, consisting of analytical tools and information management capabilities, designed to aid decision makers in solving relatively large, unstructured problems.

  16. A Stochastic Decision Support System for Economic Order Quantity Problem

    Directory of Open Access Journals (Sweden)

    Amir Yousefli

    2012-01-01

    Full Text Available Improving decisions efficiency is one of the major concerns of the decision support systems. Specially in the uncertain environment, decision support systems could be implemented efficiently to simplify decision making process. In this paper stochastic economic order quantity (EOQ problem is investigated in which decision variables and objective function are uncertain in nature and optimum probability distribution functions of them are calculated through a geometric programming model. Obtained probability distribution functions of the decision variables and the objective function are used as optimum knowledge to design a new probabilistic rule base (PRB as a decision support system for EOQ model. The developed PRB is a new type of the stochastic rule bases that can be used to infer optimum or near optimum values of the decision variables and the objective function of the EOQ model without solving the geometric programming problem directly. Comparison between the results of the developed PRB and the optimum solutions which is provided in the numerical example illustrates the efficiency of the developed PRB.

  17. System environment "Brainstorm" for support of the inherited software

    OpenAIRE

    Zimin, V. P.; Khomyakov, E. A.

    2006-01-01

    The problem of support of the inherited software, arising at accompaniment of existing applied programs packages is analyzed. Solution of the given problem with the help of system environment «BrainStorm v. 1.0» under MS Windows which allows to create and to accompany software packages which were carried out under MS-DOS is proposed. The basic mechanisms of system maintenance realized in «BrainStorm» are described. Results of testing of the given tool means are given.

  18. Calculating Outcrossing Rates used in Decision Support Systems for Ships

    DEFF Research Database (Denmark)

    Nielsen, Ulrik Dam

    2008-01-01

    Onboard decision support systems (DSS) are used to increase the operational safety of ships. Ideally, DSS can estimate - in the statistical sense - future ship responses on a time scale of the order of 1-3 hours taking into account speed and course changes. The calculations depend on both...... operational and environmental parameters that are known only in the statistical sense. The present paper suggests a procedure to incorporate random variables and associated uncertainties in calculations of outcrossing rates, which are the basis for risk-based DSS. The procedure is based on parallel system...

  19. Development of Educational Support System for Algorithm using Flowchart

    Science.gov (United States)

    Ohchi, Masashi; Aoki, Noriyuki; Furukawa, Tatsuya; Takayama, Kanta

    Recently, an information technology is indispensable for the business and industrial developments. However, it has been a social problem that the number of software developers has been insufficient. To solve the problem, it is necessary to develop and implement the environment for learning the algorithm and programming language. In the paper, we will describe the algorithm study support system for a programmer using the flowchart. Since the proposed system uses Graphical User Interface(GUI), it will become easy for a programmer to understand the algorithm in programs.

  20. Design Support System for Open Distance Learning Student Teamwork

    Science.gov (United States)

    Putranto, A.; Pradipto, Y. D.

    2017-01-01

    Open distance learning students in doing team assignment, they seldom face to some problems such as student fell unfair in numbers of workload contribution, instructors also do not know which students do more work than others. So there are some questions ie: how to connect between instructor, team members, and working documents. Methods will be used are first, analyzing current condition and last by designing systems to connect between instructor, team members, and document. The expected result is support systems for open distance learning student teamwork.

  1. Decision support system for individualized nursing procedures: SAPIEN-Tx.

    Science.gov (United States)

    Ito, M; Ramos, M P; Chern, M S; Espósito, S R; Carmagnani, M I; Cunha, I C; Piveta, V M; Nespoulos, E; Iwasa, A T; Anção, M S

    1995-01-01

    The present work proposes a Decision Support System for nursing procedures: SAPIEN-Tx. The discussion includes the acquisition, modeling , and implementation of nursing expertise professionals in Renal Transplant. It was developed to obtain better quality healthcare services, as well as an effective contribution to the nursing professional in the global assistance of their clientele. We used the KADS methodology to develop the system knowledge base. This methodology permitted us to perform the knowledge modeling with quality and organization. In opposition to the old method, errors were detected before the implementation, avoiding possible modification on the whole project structure.

  2. Aquaculture in bio-regenerative life support systems (BLSS): Considerations

    Science.gov (United States)

    Gonzales, John M.

    2009-04-01

    A significant amount of research has been invested into understanding the effects of including fish culture in bio-regenerative life support systems (BLSS) for long duration space habitation. While the benefits of fish culture as a sub-process for waste treatment and food production continue to be identified, other pressing issues arise that affect the overall equivalent system mass associated with fish culture in a BLSS. This paper is meant to provide insight into several issues affecting fish culture in a BLSS that will require attention in the future if fish meant for consumption are to be cultured in a BLSS.

  3. Bioregenerative life support system for a lunar base

    Science.gov (United States)

    Liu, H.; Wang, J.; Manukovsky, N. S.; Kovalev, V. S.; Gurevich, Yu. L.

    We have studied a modular approach to construction of bioregenerative life support system BLSS for a lunar base using soil-like substrate SLS for plant cultivation Calculations of massflow rates in BLSS were based mostly on a vegetarian diet and biological conversion of plant residues in SLS Plant candidate list for lunar BLSS includes the following basic species rice Oryza sativa soy Glycine max sweet potato Ipomoea batatas and wheat Triticum aestivum To reduce the time necessary for transition of the system to steady state we suggest that the first seeding and sprouting could be made on Earth

  4. Application of GIS in foreign direct investment decision support system

    Science.gov (United States)

    Zhou, Jianlan; Sun, Koumei

    2007-06-01

    It is important to make decisions on how to attract foreign direct investment (FDI) to China and know how the inequality of FDI introduction by locational different provinces. Following background descriptions on China's FDI economic environments and FDI-related policies, this paper demonstrates the uses of geographical information system (GIS) and multi-criterion decision-making (MCDM) framework in solving a spatial multi-objective problem of evaluating and ranking China's provinces for FDI introduction. It implements a foreign direct investment decision support system, which reveals the main determinants of FDI in China and gives some results of regional geographical analysis over spatial data.

  5. Study of customer acquisition support system for mobile operators

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The mobile operators are struggling for improving the market share and the revenues.One important method is to acquire the potential customers from the competitors.This article presents a whole acquisition process and an integrated framework for customer acquisition support system (CASS).The core of the system is the customer acquisition identification models which are built based on data mining technologies.The CASS can automate the acquisition process and decrease the cost and implement precise marketing strategy for mobile operators.

  6. A prototype auto-human support system for spatial analysis

    Institute of Scientific and Technical Information of China (English)

    LI Lianfa; WANG Jinfeng

    2006-01-01

    Spatial analysis is a multidisciplinary field that involves multiple influential factors, variation and uncertainty, and modeling of geospatial data is a complex procedure affected by spatial context, mechanism and assumptions. In order to make spatial modeling easier, some scholars have suggested a lot of knowledge from exploratory data analysis (EDA), specification of the model, fitness and diagnosis of the model, to interpretation of the model. Also an amount of software has improved some functionalities of spatial analysis, e.g. EDA by the dynamic link (GeoDa) and robust statistical calculation (R). However, there are few programs for spatial analysis that can automatically deal with unstructured declarative issues and uncertainty in machine modeling using the domain knowledge. Under this context, this paper suggests a prototype support system for spatial analysis that can automatically use experience and knowledge from the experts to deal with complexity and uncertainty in modeling. The knowledge base component, as the major contribution of the system, in support of the expert system shell, codes and stores declarative modeling knowledge, e.g. spatial context, mechanisms and prior knowledge to deal with declarative issues during the modeling procedure. With the open architecture, the system integrates functionalities of other components, e.g. GIS' visualization, DBMS, and robust calculation in an interactive environment. An application case of spatial sampling, design and implementation of spatial modeling with such a system is demonstrated.

  7. Computerized Operator Support System – Phase II Development

    Energy Technology Data Exchange (ETDEWEB)

    Ulrich, Thomas A.; Boring, Ronald L.; Lew, Roger T.; Thomas, Kenneth D.

    2015-02-01

    A computerized operator support system (COSS) prototype for nuclear control room process control is proposed and discussed. The COSS aids operators in addressing rapid plant upsets that would otherwise result in the shutdown of the power plant and interrupt electrical power generation, representing significant costs to the owning utility. In its current stage of development the prototype demonstrates four advanced functions operators can use to more efficiently monitor and control the plant. These advanced functions consist of: (1) a synthesized and intuitive high level overview display of system components and interrelations, (2) an enthalpy-based mathematical chemical and volume control system (CVCS) model to detect and diagnose component failures, (3) recommended strategies to mitigate component failure effects and return the plant back to pre-fault status, and (4) computer-based procedures to walk the operator through the recommended mitigation actions. The COSS was demonstrated to a group of operators and their feedback was collected. The operators responded positively to the COSS capabilities and features and indicated the system would be an effective operator aid. The operators also suggested several additional features and capabilities for the next iteration of development. Future versions of the COSS prototype will include additional plant systems, flexible computer-based procedure presentation formats, and support for simultaneous component fault diagnosis and dual fault synergistic mitigation action strategies to more efficiently arrest any plant upsets.

  8. Improving enterprise system support - a case-based approach

    DEFF Research Database (Denmark)

    Wognum, P.M.; Krabbendam, J.J.; Buhl, Henrik

    2004-01-01

    of a comprehensive reference framework. After this step a tool has been developed to support a consultant in assessing the maturity of a company to start an enterprise system implementation project. The knowledge, used directly in the tool, makes it possible to suggest improvement actions sensitive to the situation......Many organisations have implemented or are implementing large enterprise systems, like ERP and PDM, for integrating their business functions and streamlining the flow of information. Implementing such systems is very complex, however. In many companies the results envisioned have not or have only...... partly been achieved. In the literature many explanations can be found for insufficient or failing implementation efforts. A large part of the problems encountered appears to be human and organisational in nature, while it has been stressed that implementing an enterprise system requires and involves...

  9. Improving the implementation of clinical decision support systems.

    Science.gov (United States)

    Rüping, Stefan; Anguita, Alberto; Bucur, Anca; Cirstea, Traian Cristian; Jacobs, Björn; Torge, Antje

    2013-01-01

    Clinical decision support (CDS) systems promise to improve the quality of clinical care by helping physicians to make better, more informed decisions efficiently. However, the design and testing of CDS systems for practical medical use is cumbersome. It has been recognized that this may easily lead to a problematic mismatch between the developers' idea of the system and requirements from clinical practice. In this paper, we will present an approach to reduce the complexity of constructing a CDS system. The approach is based on an ontological annotation of data resources, which improves standardization and the semantic processing of data. This, in turn, allows to use data mining tools to automatically create hypotheses for CDS models, which reduces the manual workload in the creation of a new model. The approach is implemented in the context of EU research project p-medicine. A proof of concept implementation on data from an existing Leukemia study is presented.

  10. Pearls and pitfalls in short-term mechanical circulatory assist: how to avoid and manage complications.

    Science.gov (United States)

    Mohite, Prashant N; Maunz, Olaf; Simon, Andre R

    2014-10-01

    In today's era, given the worsening risk profiles of patients undergoing cardiac surgery, the increasing number of complex cardiac surgeries, and the increasing number of patients undergoing thoracic organ transplantation, short-term mechanical circulatory assist (MCA) devices are indispensable. MCA devices are capable of supporting heart and lung function and have emerged as potentially lifesaving instruments, but may prove to be as hazardous as helpful due to their inherent tendency toward hemolysis, thromboembolism, and hemorrhage. Although MCA devices are being used regularly at some specialized centers, surgeries involving MCA are not as common as other routine cardiac surgeries, and even though professionals implanting and maintaining short-term MCAs are well acquainted with operating such devices, it is not uncommon to come across complications as a result of minor mistakes committed while dealing with them. Avoiding simple mistakes and taking proper precautions while implanting and maintaining these devices can prevent major catastrophes. We discuss commonly encountered problems and complications during the implantation and maintenance of short-term MCAs and offer reasonable and practical solutions. In addition, crucial issues such as anticoagulation, replacement of the device circuit, and management of the distal perfusion cannula are discussed. Continuous and efficient monitoring of the MCA device and the patient supported on MCA, together with anticipation and avoidance of complications, is key for successful short-term MCA support.

  11. Closure of Regenerative Life Support Systems: Results of the Lunar-Mars Life Support Test Project

    Science.gov (United States)

    Barta, Daniel; Henninger, D.; Edeen, M.; Lewis, J.; Smth, F.; Verostko, C.

    2006-01-01

    Future long duration human exploration missions away from Earth will require closed-loop regenerative life support systems to reduce launch mass, reduce dependency on resupply and increase the level of mission self sufficiency. Such systems may be based on the integration of biological and physiocochemical processes to produce potable water, breathable atmosphere and nutritious food from metabolic and other mission wastes. Over the period 1995 to 1998 a series of ground-based tests were conducted at the National Aeronautics and Space Administration, Johnson Space Center, to evaluate the performance of advanced closed-loop life support technologies with real human metabolic and hygiene loads. Named the Lunar-Mars Life Support Test Project (LMLSTP), four integrated human tests were conducted with increasing duration, complexity and closure. The first test, LMLSTP Phase I, was designed to demonstrate the ability of higher plants to revitalize cabin atmosphere. A single crew member spent 15 days within an atmospherically closed chamber containing 11.2 square meters of actively growing wheat. Atmospheric carbon dioxide and oxygen levels were maintained by control of the rate of photosynthesis through manipulation of light intensity or the availability of carbon dioxide and included integrated physicochemical systems. During the second and third tests, LMLSTP Phases II & IIa, four crew members spent 30 days and 60 days, respectively, in a larger sealed chamber. Advanced physicochemical life support hardware was used to regenerate the atmosphere and produce potable water from wastewater. Air revitalization was accomplished by using a molecular sieve and a Sabatier processor for carbon dioxide absorption and reduction, respectively, with oxygen generation performed by water hydrolysis. Production of potable water from wastewater included urine treatment (vapor compression distillation), primary treatment (ultrafiltration/reverse osmosis and multi-filtration) and post

  12. Knowledge model-based decision support system for maize management

    Institute of Scientific and Technical Information of China (English)

    GUO Yinqiao; ZHAO Chuande; WANG Wenxin; LI Cundong

    2007-01-01

    Based on the relationship between crops and circumstances,a dynamic knowledge model for maize management with wide applicability was developed using the system method and mathematical modeling technique.With soft component characteristics incorporated,a component and digital knowledge model-based decision support system for maize management was established on the Visual C++platform.This system realized six major functions:target yield calculation,design of pre-sowing plan,prediction of regular indices,real-time management control,expert knowledge reference and system administration.Cases were studied on the target yield knowledge model with data sets that include different eco-sites,yield levels of the last three years,and fertilizer and water management levels.The results indicated that this system overcomes the shortcomings of traditional expert systems and planting patterns,such as sitespecific conditions and narrow applicability,and can be used more under different conditions and environments.This system provides a scientific knowledge system and a broad decision-making tool for maize management.

  13. Integrated ADIOS-IGENPRO operator advisory support system

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Dong Young; Park, J. H.; Kim, J. T.; Kim, C. H.; Park, W. M.; Hwang, I. K.; Cheon, S. W.; Song, S. J

    2001-05-01

    The I and C systems and control rooms of nuclear power plants have been constructed by using the automatic control concept and changed to computer-based systems in nowadays. For Increase of an automation and CRT, the role of operators is changed to monitor the condition of the nuclear power plants. Therefore, the information that is offered to operators has to integrate in order for operator to understand the hole condition of plants. In commercial nuclear plants, raw data of sensors and components are shown in a control room. So, operators can not diagnose the condition of plants correctly. For a development of an integrated operator aid system which contain an alarm processing system and a fault diagnosis system, we integrated IGENPRO of ANL(Argonne National Lab.) and ADIOS of KAERI (Korea Atomic Energy Institute). IGENPRO is a fault diagnosis system contains three module such as PROTREN, PRODIAG and PROTREN. ADIOS is an alarm processing system that informs operators of important alarms. The integrated operator advisory support system developed in the research is composed of an alarm processing module and a fault diagnosis module. The alarm processing module shows important alarms to operator by using dynamic alarm filtering methods. The fault diagnosis module shows the cause of faults of sensors and hardwares.

  14. Implementation of Combat Simulation Through Expert Support Systems

    Directory of Open Access Journals (Sweden)

    M. R. Subramanian

    1987-10-01

    Full Text Available The battlefield simulation is often faced with a bewildering array of conflicting stresses and challenges. Communication is currently slower and more costly than computation. Expert System technologies such as production rule systems allow one to acquire and represent the collection of heuristic rules in computer compatible form. The system also include master control programs that determine the order in which these rules should be applied against the monitored system performance to arrive at appropriate system control. These expert systems are used in two nodes, both as an intelligence assistant to the expert, amplifying the capacity and quality of his work, and as a surrogate for an expert when he is not available. An Expert support System (ESS designed and developed for combat simulation has been enumerated in this article. The quality and the reliability of the inferred tactical situation is improved by using PROLOG. This formal AI language is used for validating and checking sensor detections for consistency and logical plausibility. The supremacy of PROLOG for creating and interrogating a data base helps maintaining a reasonably coherent feature of the tactical situation. The perils and pitfalls of tackling with expert systems have also been underscored.

  15. Identifying Opportunities for Decision Support Systems in Support of Regional Resource Use Planning: An Approach Through Soft Systems Methodology.

    Science.gov (United States)

    Zhu; Dale

    2000-10-01

    / Regional resource use planning relies on key regional stakeholder groups using and having equitable access to appropriate social, economic, and environmental information and assessment tools. Decision support systems (DSS) can improve stakeholder access to such information and analysis tools. Regional resource use planning, however, is a complex process involving multiple issues, multiple assessment criteria, multiple stakeholders, and multiple values. There is a need for an approach to DSS development that can assist in understanding and modeling complex problem situations in regional resource use so that areas where DSSs could provide effective support can be identified, and the user requirements can be well established. This paper presents an approach based on the soft systems methodology for identifying DSS opportunities for regional resource use planning, taking the Central Highlands Region of Queensland, Australia, as a case study.

  16. Information System Engineering Supporting Observation, Orientation, Decision, and Compliant Action

    Science.gov (United States)

    Georgakopoulos, Dimitrios

    The majority of today's software systems and organizational/business structures have been built on the foundation of solving problems via long-term data collection, analysis, and solution design. This traditional approach of solving problems and building corresponding software systems and business processes, falls short in providing the necessary solutions needed to deal with many problems that require agility as the main ingredient of their solution. For example, such agility is needed in responding to an emergency, in military command control, physical security, price-based competition in business, investing in the stock market, video gaming, network monitoring and self-healing, diagnosis in emergency health care, and many other areas that are too numerous to list here. The concept of Observe, Orient, Decide, and Act (OODA) loops is a guiding principal that captures the fundamental issues and approach for engineering information systems that deal with many of these problem areas. However, there are currently few software systems that are capable of supporting OODA. In this talk, we provide a tour of the research issues and state of the art solutions for supporting OODA. In addition, we provide specific examples of OODA solutions we have developed for the video surveillance and emergency response domains.

  17. How Turing and Wolf influenced my Decision Support Systems.

    Science.gov (United States)

    Richards, Bernard

    2013-01-01

    Decision Support Systems (DSS) have a vital role to play in today's scenario for Patient Care. They can embody a vast knowledge not normally found in one individual where diagnosis and treatment are involved. This paper highlights the training in minute details and precise mathematics needed in a successful DSS and indicates how such attention-to-detail was instilled into the writer as a result of working with Alan Turing and Emil Wolf who have both since achieved world-wide recognition in their own fields as a result of international publicity by the current writer. The article discusses four Decision Support Systems written by the present writer all of which have been shown to improve patient treatment and care, and which are of such complexity that, without their use, patient care would fall short of optimum. The Systems considered are those for Intensive Care Units, Cardiovascular Surgery, a Programmed Investigation Unit, and Diagnosis of Congenital Abnormalities. All these Systems have performed better than the human alternatives and have shown their value in the improvement of patient care.

  18. Advanced Technologies to Improve Closure of Life Support Systems

    Science.gov (United States)

    Barta, Daniel J.

    2016-01-01

    As NASA looks beyond the International Space Station toward long-duration, deep space missions away from Earth, the current practice of supplying consumables and spares will not be practical nor affordable. New approaches are sought for life support and habitation systems that will reduce dependency on Earth and increase mission sustainability. To reduce launch mass, further closure of Environmental Control and Life Support Systems (ECLSS) beyond the current capability of the ISS will be required. Areas of particular interest include achieving higher degrees of recycling within Atmosphere Revitalization, Water Recovery and Waste Management Systems. NASA is currently investigating advanced carbon dioxide reduction processes that surpass the level of oxygen recovery available from the Sabatier Carbon Dioxide Reduction Assembly (CRA) on the ISS. Candidate technologies will potentially improve the recovery of oxygen from about 50% (for the CRA) to as much as 100% for technologies who's end product is solid carbon. Improving the efficiency of water recycling and recovery can be achieved by the addition of advanced technologies to recover water from brines and solid wastes. Bioregenerative technologies may be utilized for water reclaimation and also for the production of food. Use of higher plants will simultaneously benefit atmosphere revitalization and water recovery through photosynthesis and transpiration. The level at which bioregenerative technologies are utilized will depend on their comparative requirements for spacecraft resources including mass, power, volume, heat rejection, crew time and reliability. Planetary protection requirements will need to be considered for missions to other solar system bodies.

  19. Decision Support Systems (DSS in Construction Tendering Processes

    Directory of Open Access Journals (Sweden)

    Rosmayati Mohemad

    2010-03-01

    Full Text Available The successful execution of a construction project is heavily impacted by making the right decision during tendering processes. Managing tender procedures is very complex and uncertain involving coordination of many tasks and individuals with different priorities and objectives. Bias and inconsistent decision are inevitable if the decision-making process is totally depends on intuition, subjective judgement or emotion. In making transparent decision and healthy competition tendering, there exists a need for flexible guidance tool for decision support. Aim of this paper is to give a review on current practices of Decision Support Systems (DSS technology in construction tendering processes. Current practices of general tendering processes as applied to the most countries in different regions such as United States, Europe, Middle East and Asia are comprehensively discussed. Applications of Web-based tendering processes is also summarised in terms of its properties. Besides that, a summary of Decision Support System (DSS components is included in the next section. Furthermore, prior researches on implementation of DSS approaches in tendering processes are discussed in details. Current issues arise from both of paper-based and Web-based tendering processes are outlined. Finally, conclusion is included at the end of this paper.

  20. Tool for Sizing Analysis of the Advanced Life Support System

    Science.gov (United States)

    Yeh, Hue-Hsie Jannivine; Brown, Cheryl B.; Jeng, Frank J.

    2005-01-01

    Advanced Life Support Sizing Analysis Tool (ALSSAT) is a computer model for sizing and analyzing designs of environmental-control and life support systems (ECLSS) for spacecraft and surface habitats involved in the exploration of Mars and Moon. It performs conceptual designs of advanced life support (ALS) subsystems that utilize physicochemical and biological processes to recycle air and water, and process wastes in order to reduce the need of resource resupply. By assuming steady-state operations, ALSSAT is a means of investigating combinations of such subsystems technologies and thereby assisting in determining the most cost-effective technology combination available. In fact, ALSSAT can perform sizing analysis of the ALS subsystems that are operated dynamically or steady in nature. Using the Microsoft Excel spreadsheet software with Visual Basic programming language, ALSSAT has been developed to perform multiple-case trade studies based on the calculated ECLSS mass, volume, power, and Equivalent System Mass, as well as parametric studies by varying the input parameters. ALSSAT s modular format is specifically designed for the ease of future maintenance and upgrades.

  1. Development of an advanced support system for site investigations

    Science.gov (United States)

    Mizuno, T.; Hama, K.; Iwatsuki, T.; Semba, T.

    2009-12-01

    JAEA has the responsibility for R&D to enhance reliability of High Level Waste (HLW) disposal technology and to develop safety assessment methodology with associated databases; these should support both the implementer (NUMO) and the relevant regulatory organizations. With this responsibility, JAEA has initiated development of advanced technology in the field of Knowledge Engineering. Known as the Information Synthesis and Interpretation System (ISIS), it incorporates knowledge currently being obtained in the Underground Research Laboratory (URL) projects in Expert System (ES) modules for the Japanese HLW disposal program. This knowledge includes fundamental understanding of relevant geological environments, technical know-how for the application of complex investigation techniques, experience gained in earlier site work, etc. However, much knowledge is not undocumented because the knowledge is treated as tacit knowledge and, without focused action soon, may be permanently lost. Therefore, a new approach is necessary to transfer the knowledge obtained in these URL projects to support the site characterization and subsequent safety assessment of potential repository sites by NUMO and the formulation of guidelines by regulatory organizations. In this paper, we introduce the ES for selecting tracers for borehole drilling. ES is the system built by applying electronic information technology to support the planning, conducting investigations and assessing of investigation results. Tracers are generally used for borehole drilling to monitor and quantitatively assess the degree of contamination of groundwater by drilling fluid. JAEA uses fluorescent dye as tracer in drilling fluid. When a fluorescent dye is used for drilling, suitable type and concentration must be selected. The technical points to be considered are; 1) linearity of fluorescent spectrum intensity with variations in concentration, 2) pH dependence of fluorescent spectrum intensity, 3) stability of

  2. Method for designing organization decision support system framework

    Institute of Scientific and Technical Information of China (English)

    Fan Jiancong; Liang Yongquan; Zeng Qingtian

    2006-01-01

    The concept of organization decision support system (ODSS) is defined according to practical applications and novel understanding. And a framework for ODSS is designed. The framework has three components: infrastructure, decision-making process and decision execution process. Infrastructure is responsible to transfer data and information. Decision-making process is the ODSS's soul to support decision-making. Decision execution process is to evaluate and execute decision results derived from decision-making process. The framework presents a kind of logic architecture. An example is given to verify and analyze the framework. The analysis shows that the framework has practical values, and has also reference values for understanding ODSS and for theoretical studies.

  3. Fault Isolation for Nonlinear Systems Using Flexible Support Vector Regression

    Directory of Open Access Journals (Sweden)

    Yufang Liu

    2014-01-01

    Full Text Available While support vector regression is widely used as both a function approximating tool and a residual generator for nonlinear system fault isolation, a drawback for this method is the freedom in selecting model parameters. Moreover, for samples with discordant distributing complexities, the selection of reasonable parameters is even impossible. To alleviate this problem we introduce the method of flexible support vector regression (F-SVR, which is especially suited for modelling complicated sample distributions, as it is free from parameters selection. Reasonable parameters for F-SVR are automatically generated given a sample distribution. Lastly, we apply this method in the analysis of the fault isolation of high frequency power supplies, where satisfactory results have been obtained.

  4. Spaceport Command and Control System - Support Software Development

    Science.gov (United States)

    Tremblay, Shayne

    2016-01-01

    The Information Architecture Support (IAS) Team, the component of the Spaceport Command and Control System (SCCS) that is in charge of all the pre-runtime data, was in need of some report features to be added to their internal web application, Information Architecture (IA). Development of these reports is crucial for the speed and productivity of the development team, as they are needed to quickly and efficiently make specific and complicated data requests against the massive IA database. These reports were being put on the back burner, as other development of IA was prioritized over them, but the need for them resulted in internships being created to fill this need. The creation of these reports required learning Ruby on Rails development, along with related web technologies, and they will continue to serve IAS and other support software teams and their IA data needs.

  5. Decision Support in Heart Disease Prediction System using Naive Bayes

    Directory of Open Access Journals (Sweden)

    G.Subbalakshmi,

    2011-04-01

    Full Text Available Data Mining refers to using a variety of techniques to identify suggest of information or decision making knowledge in thedatabase and extracting these in a way that they can put to use in areas such as decision support, predictions, forecasting and estimation. The healthcare industry collects huge amounts of healthcare data which, unfortunately, are not “mined” to discover hidden information for effective decision making. Discovering relations that connect variables in a database is the subject of data mining. This research has developed a Decision Support in Heart Disease Prediction System (DSHDPS using data mining modeling technique, namely, Naïve Bayes. Using medical profiles such as age, sex, blood pressure and blood sugar it can predict the likelihood of patients getting a heart disease. It is implemented as web based questionnaire application. It can serve a training tool to train nurses and medical students to diagnose patients with heart disease.

  6. Electronic market models for decision support systems on the Web

    Institute of Scientific and Technical Information of China (English)

    谢勇; 王红卫; 费奇

    2004-01-01

    With the prevalence of the Web, most decision-makers are likely to use the Web to support their decision-making. Web-based technologies are leading a major stream of researching decision support systems (DSS). We propose a formal definition and a conceptual framework for Web-based open DSS (WODSS). The formal definition gives an overall view of WODSS, and the conceptual framework based on browser/broker/server computing mode employs the electronic market to mediate decision-makers and providers, and facilitate sharing and reusing of decision resources. We also develop an admitting model, a trading model and a competing model of electronic market in WODSS based on market theory in economics. These models reveal the key mechanisms that drive WODSS operate efficiently.

  7. Decision Support Systems: Usage And Applications In Logistics Services

    Directory of Open Access Journals (Sweden)

    Eyüp AKÇETİN

    2014-06-01

    Full Text Available Competitive advantage in logistics operations is possible by analyzing data to create information and turning that information into decision. Supply chain optimization depends on effective management of chain knowledge. Analyzing data from supply chain and making a decision creates complex operations. Therefore, these operations require benefitting from information technology. In today’s global world, businesses use outsourcing for logistics services to focus on their own field, so are seeking to achieve competitive advantage against competitors. Outsourcing requires sharing of various information and data with companies that provide logistical support. Effective strategies are based on well-analyzed the data and information. Best options for right decisions can be created only from good analysis. That’s why companies that supply logistics services achieve competitive advantage using decision support systems (DSS in industrial competition. In short, DSS has become driving force for every business in today’s knowledge-based economy.

  8. Managing smarter: a decision support system for mental health providers.

    Science.gov (United States)

    Mohan, L; Muse, L; McInerney, C

    1998-11-01

    Financing of mental health care has changed radically, especially with managed care. Shrinking revenues have forced providers to look for creative ways in which to provide quality services at less expense. Delivery of quality services depends largely on the productive use of the provider's prime resource--the clinicians. Productivity was the focus of the PC-based decision support system developed for mental health providers in New York State. It enables administrators to track key indicators of productivity such as face-to-face time and non-face-to-face time against goals. Unmet goals can be pinpointed quickly, and clinicians' caseloads can be reviewed to determine the underlying causes. A key feature of the system is the conversion of raw data into actionable information to help in problem finding and problem solving. The system has been implemented in Ulster County, the pilot site for the project. The software can be customized easily to suit the data of other providers.

  9. Research design of decision support system for team sport

    Science.gov (United States)

    Abidin, Mohammad Zukuwwan Zainol; Nawawi, Mohd Kamal Mohd; Kasim, Maznah Mat

    2016-10-01

    This paper proposes a suitable research procedure that can be referred to while conducting a Decision Support System (DSS) study, especially when the development activity of system artifacts becomes one of the research objectives. The design of the research procedure was based on the completion of a football DSS development that can help in determining the position of a player and the best team formation to be used during a game. After studying the relevant literature, we found that it is necessary to combine the conventional rainfall System Development Life Cycle (SDLC) approach with Case Study approach to help in structuring the research task and phases, which can contribute to the fulfillment of the research aim and objectives.

  10. PERFUSION SYSTEM CONTROLLER STRATEGIES DURING AN ECMO SUPPORT

    Directory of Open Access Journals (Sweden)

    M.Dhinakaran

    2014-12-01

    Full Text Available In this work modelling and control of Perfusion system is presented. The Perfusion system simultaneously controls the partial pressures during Extra Corporeal Membrane Oxygenation (ECMO support. The main Problem in ECMO system is exchange of Blood Gases in the Artificial Lung (Oxygenator.It is a highly Nonlinear Process comprising time-varying parameters, and varying time delays, it is currently being controlled manually by trained Perfusionist. The new control strategy implemented here has a feedback linearization routine with time-delay compensation for the Partial pressuresof Oxygen and Carbon dioxide. The controllers were tuned robustly and tested in simulations with a detailed artificial Lung (Oxygenator model in Cardiopulmonary bypass conditions. This Automatic control strategy is proposed to improve the patient’s safety by fast control reference tracking and good disturbance rejection under varying conditions.

  11. Testing to Support Improvements to PV Components and Systems

    Energy Technology Data Exchange (ETDEWEB)

    THOMAS,H.; KROPOSKI,B.; WITT,C.; BOWER,WARD I.; BONN,RUSSELL H.; GINN,JERRY W.; GONZALEZ,SIGIFREDO

    2000-07-15

    The National Photovoltaic (PV) Program is sponsored by the US Department of Energy and includes a PV Manufacturing Research and Development (R and D) project conducted with industry. This project includes advancements in PV components to improve reliability, reduce costs, and develop integrated PV systems. Participants submit prototypes, pre-production hardware products, and examples of the resulting final products for a range of tests conducted at several national laboratories, independent testing laboratories, and recognized listing agencies. The purpose of this testing is to use the results to assist industry in determining a product's performance and reliability, and to identify areas for potential improvement. This paper briefly describes the PV Manufacturing R and D project, participants in the area of PV systems, balance of systems, and components, and several examples of the different types of product and performance testing used to support and confirm product performance.

  12. Software Tools to Support the Assessment of System Health

    Science.gov (United States)

    Melcher, Kevin J.

    2013-01-01

    This presentation provides an overview of three software tools that were developed by the NASA Glenn Research Center to support the assessment of system health: the Propulsion Diagnostic Method Evaluation Strategy (ProDIMES), the Systematic Sensor Selection Strategy (S4), and the Extended Testability Analysis (ETA) tool. Originally developed to support specific NASA projects in aeronautics and space, these software tools are currently available to U.S. citizens through the NASA Glenn Software Catalog. The ProDiMES software tool was developed to support a uniform comparison of propulsion gas path diagnostic methods. Methods published in the open literature are typically applied to dissimilar platforms with different levels of complexity. They often address different diagnostic problems and use inconsistent metrics for evaluating performance. As a result, it is difficult to perform a one ]to ]one comparison of the various diagnostic methods. ProDIMES solves this problem by serving as a theme problem to aid in propulsion gas path diagnostic technology development and evaluation. The overall goal is to provide a tool that will serve as an industry standard, and will truly facilitate the development and evaluation of significant Engine Health Management (EHM) capabilities. ProDiMES has been developed under a collaborative project of The Technical Cooperation Program (TTCP) based on feedback provided by individuals within the aircraft engine health management community. The S4 software tool provides a framework that supports the optimal selection of sensors for health management assessments. S4 is structured to accommodate user ]defined applications, diagnostic systems, search techniques, and system requirements/constraints. One or more sensor suites that maximize this performance while meeting other user ]defined system requirements that are presumed to exist. S4 provides a systematic approach for evaluating combinations of sensors to determine the set or sets of

  13. Adsorption processes in spacecraft environmental control and life support systems.

    Science.gov (United States)

    DallBauman, L A; Finn, J E

    1999-01-01

    The environmental control and life support system on a spacecraft maintains a safe and comfortable environment in which the crew can live and work by supplying oxygen and water and by removing carbon dioxide, water vapor, and trace contaminants from cabin air. Although open-loop systems have been used successfully in the past for short-duration missions, the economics of current and future long-duration missions in space will make nearly complete recycling of air and water imperative. A variety of operations will be necessary to achieve the goal of nearly complete recycling. These include separation and reduction of carbon dioxide, removal of trace gas-phase contaminants, recovery and purification of humidity condensate, purification and polishing of wastewater streams, and others. Several of these can be performed totally or in part by adsorption processes. These processes are good candidates to perform separations and purifications in space due to their gravity independence, high reliability, relative high energy efficiency, design flexibility, technological maturity, and regenerative nature. For these reasons, adsorption has historically played a key role in life support on U.S. and Russian piloted spacecraft. Among the life support applications that can be achieved through use of adsorption technology are removal of trace contaminants and carbon dioxide from cabin air and recovery of potable water from waste streams. In each of these cases adsorption technology has been selected for use onboard the International Space Station. The requirements, science, and hardware for these applications are discussed. Human space exploration may eventually lead to construction of planetary habitats. These habitats may provide additional opportunities for use of adsorption processes, such as control of greenhouse gas composition, and may have different resources available to them, such as gases present in the planetary atmosphere. Separation and purification processes based on

  14. STUDY OF A FAULT DIAGNOSIS EXPERT SYSTEM FOR SYNTHETIC MINING SYSTEM HYDRAULIC SUPPORT

    Institute of Scientific and Technical Information of China (English)

    Han Yilun

    2000-01-01

    Fault diagnosis expert system for hydraulic support is studied.The system is achieved by Turbo-prolong Language, it summaries the experience of the domain expert and sets up a fault tree, knowledge base is developed by a productive rule.According to the feature of diagnosis, the system selects forward non-determination inferring and limited depth-first search strategy.It can accomplish expert diagnosis of more than 50 kinds faults in hydraulic support.

  15. A System Supporting the Analysis of Motorway Traffic Accidents

    Directory of Open Access Journals (Sweden)

    Davide Anghinolfi

    2015-12-01

    Full Text Available This work presents a business intelligence tool for monitoring traffic accidents on motorways and supporting decisions relevant to road safety. The system manages information on road characteristics, traffic accidents and traffic volumes and produces reports for monitoring the evolution of key performance indicators for road safety, supporting decisions on actions for risk mitigation and safety improvements for road users. The paper illustrates the different types of analyses performed by the system. Pattern based analysis is used to evaluate safety performance indicators for the road sections matching defined patterns. Two different road segmentation algorithms, used to identify the most critical road sections according to various severity indicators, are presented and discussed. Differential analysis compares the value of selected severity indicators before and after the implementation of an intervention on a road. Finally, a graphical user interface allows the accident locations to be visualized and accidents with specific characteristics to be highlighted. The system was evaluated on the data collected between 2009 and 2011 for the A15 motorway in Italy, connecting Parma to La Spezia.

  16. Post-Sale Customer Support Methodology in the TQM System

    Directory of Open Access Journals (Sweden)

    Dr.Sc. Elizabeta Mitreva

    2014-06-01

    Full Text Available In this paper a survey of the activities in the post-sale period of the product is made and based on the analysis of the results, a methodology that managers could use to design and implement the system of total quality management has been created. The implementation of this methodology is carried out in a simplified way and in less time, without having to study and deepen new knowledge for internal standardization, statistical process control, cost analysis and optimization of business processes The purpose of this paper is to lay a good foundation for Macedonian companies in their post-sale period activities of the product, to understand the philosophy of TQM (Total Quality Management and benefits will be achieved by implementing the system and setting strategic directions for success. These activities begin by identifying the wishes and needs of customers/users, reengineering business processes for sales support, satisfaction of employees and all stakeholders. As a result of the implementation of this methodology in practice, improved competitiveness, increased efficiency, reduction of quality costs and increased productivity are noted. The methodology proposed in this paper brings together all the activities in the spiral of quality in a company that deals with post-sales support. Due to the necessity of flow of information about quality in the entire enterprise, an information system is designed accordingly to the QC-CEPyramid model in several steps.

  17. Automation, decision support, and expert systems in nephrology.

    Science.gov (United States)

    Soman, Sandeep; Zasuwa, Gerard; Yee, Jerry

    2008-01-01

    Increasing data suggest that errors in medicine occur frequently and result in substantial harm to the patient. The Institute of Medicine report described the magnitude of the problem, and public interest in this issue, which was already large, has grown. The traditional approach in medicine has been to identify the persons making the errors and recommend corrective strategies. However, it has become increasingly clear that it is more productive to focus on the systems and processes through which care is provided. If these systems are set up in ways that would both make errors less likely and identify those that do occur and, at the same time, improve efficiency, then safety and productivity would be substantially improved. Clinical decision support systems (CDSSs) are active knowledge systems that use 2 or more items of patient data to generate case specific recommendations. CDSSs are typically designed to integrate a medical knowledge base, patient data, and an inference engine to generate case specific advice. This article describes how automation, templating, and CDSS improve efficiency, patient care, and safety by reducing the frequency and consequences of medical errors in nephrology. We discuss practical applications of these in 3 settings: a computerized anemia-management program (CAMP, Henry Ford Health System, Detroit, MI), vascular access surveillance systems, and monthly capitation notes in the hemodialysis unit.

  18. Collaborative Decision Support Systems for Primary Health care Managers

    Directory of Open Access Journals (Sweden)

    Gunjan Pahuja

    2012-03-01

    Full Text Available In this paper, a collaborative DSS Model for health care systems and results obtained are described. The proposed framework [1] embeds expert knowledge within DSS to provide intelligent decision support, and implements the intelligent DSS using collaboration technologies. The problem space contains several Hub and Spoke networks. Information about such networks is dynamically captured and represented in a Meta-data table. This master table enables collaboration between any two networks in the problem space, through load transfer, between them. In order to show the collaboration the sample database of 15 health care centers is taken assuming that there are 5 health care centers in one network.

  19. Development of a Mixed Scanning Interactive System for Decision Support.

    Science.gov (United States)

    1984-07-01

    0542 IEEE TRANSACTIONS ON SYSTEMS, MAN, AND CYBEN ETIca , VOL SMC-10, NO. 12, DBCDMER 1980 891 REFERENCES The options assumed available to the...nore gen - and decision support is strong; consequently there erally determining the set P2 9H x n, where (7’, is much motivation to seek an approach...1. 8 -h* a. o" 6*81t & aS t hSO.418 bal-.. 0) * 11. $500 $750 3 1.0 .5 3/S 5-1000.0 A - $0 IS) C.-. SiLaiata 6 Decisin treefor ~ Fig. 3. Gen . probi

  20. Data assimilation in the decision support system RODOS

    DEFF Research Database (Denmark)

    Rojas-Palma, C.; Madsen, H.; Gering, F.;

    2003-01-01

    Model predictions for a rapid assessment and prognosis of possible radiological consequences after an accidental release of radionuclides play an important role in nuclear emergency management. Radiological observations, e.g. dose rate measurements. can be used to improve such model predictions....... The process of combining model predictions and observations, usually referred to as data assimilation, is described in this article within the framework of the real time on-line decision support system (RODOS) for off-site nuclear emergency management in Europe. Data assimilation capabilities, based on Kalman...

  1. Scheduling and development support in the Scavenger cyber foraging system

    DEFF Research Database (Denmark)

    Kristensen, Mads Darø; Bouvin, Niels Olof

    2010-01-01

    Cyber foraging is a pervasive computing technique where small mobile devices offload resource intensive tasks to stronger computing machinery in the vicinity. One of the main challenges within cyber foraging is that it is very difficult to develop cyber foraging enabled applications. An application...... using cyber foraging is working with mobile, distributed and, possibly, parallel computing; fields within computer science notoriously hard for programmers to grasp. This paper presents Scavenger—a cyber foraging system supporting easy development of mobile cyber foraging applications, while still...

  2. Towards Conceptual Multidimensional Design in Decision Support Systems

    CERN Document Server

    Teste, Olivier

    2010-01-01

    Multidimensional databases support efficiently on-line analytical processing (OLAP). In this paper, we depict a model dedicated to multidimensional databases. The approach we present designs decisional information through a constellation of facts and dimensions. Each dimension is possibly shared between several facts and it is organised according to multiple hierarchies. In addition, we define a comprehensive query algebra regrouping the more popular multidimensional operations in current commercial systems and research approaches. We introduce new operators dedicated to a constellation. Finally, we describe a prototype that allows managers to query constellations of facts, dimensions and multiple hierarchies.

  3. Developing SASSA: a Soil Analysis Support System for Archaeologists

    Directory of Open Access Journals (Sweden)

    Clare Wilson

    2008-12-01

    Full Text Available There is constant pressure on field archaeologists to be familiar with the core concepts of a diverse range of specialist disciplines. Soils and sediments are an integral part of archaeological sites, and soil and sedimentary analyses applied to archaeological questions are now recognised as an important branch of geoarchaeology. However, the teaching of soils in archaeology degrees is variable and many archaeologists complain they lack the confidence and skills to describe and interpret properly the deposits they excavate. SASSA (Soil Analysis Support System for Archaeologists is a free-to-use, internet-based system designed to familiarise archaeologists with the concepts and possibilities offered by the scientific study of soils and sediments associated with archaeological sites. The aims of SASSA are: ◦To provide soils training specifically for archaeologists, suitable for either a university or workplace setting. ◦To provide a freely accessible soils and archaeology knowledge base for archaeologists working in either the office or the field. ◦To support archaeologists describing and interpreting soils in the field. ◦To enhance understanding of the types of archaeological questions that soil analysis can help to address. ◦To initiate dialogue between archaeologists, geoarchaeologists, and soil scientists in order to encourage the thoughtful application of soil analyses to archaeological questions. SASSA consists of two core components: a knowledge base and a field tool. The 'front-end' of the website is the knowledge base; this uses wiki technology to allow users to add their own content and encourage dialogue between archaeologists and geoarchaeologists. The field tool uses an XML data structure and decision-tree support system to guide the user through the process of describing and interpreting soils and sediments. SASSA is designed for use on both 'static' (PC and 'mobile' (PDA and laptop hardware in order to provide in situ

  4. Functional Interface Considerations within an Exploration Life Support System Architecture

    Science.gov (United States)

    Perry, Jay L.; Sargusingh, Miriam J.; Toomarian, Nikzad

    2016-01-01

    As notional life support system (LSS) architectures are developed and evaluated, myriad options must be considered pertaining to process technologies, components, and equipment assemblies. Each option must be evaluated relative to its impact on key functional interfaces within the LSS architecture. A leading notional architecture has been developed to guide the path toward realizing future crewed space exploration goals. This architecture includes atmosphere revitalization, water recovery and management, and environmental monitoring subsystems. Guiding requirements for developing this architecture are summarized and important interfaces within the architecture are discussed. The role of environmental monitoring within the architecture is described.

  5. Data Mining for Web-Based Support Systems: A Case Study in e-Custom Systems

    Science.gov (United States)

    Razmerita, Liana; Kirchner, Kathrin

    This chapter provides an example of a Web-based support system (WSS) used to streamline trade procedures, prevent potential security threats, and reduce tax-related fraud in cross-border trade. The architecture is based on a service-oriented architecture that includes smart seals and Web services. We discuss the implications and suggest further enhancements to demonstrate how such systems can move toward a Web-based decision support system with the support of data mining methods. We provide a concrete example of how data mining can help to analyze the vast amount of data collected while monitoring the container movements along its supply chain.

  6. The Virtual Habitat - a tool for Life Support Systems optimization

    Science.gov (United States)

    Czupalla, Markus; Dirlich, Thomas; Harder, Jan; Pfeiffer, Matthias

    In the course of designing Life Support Systems (LSS) a great multitude of concepts for and various combinations of subsystems and components are developed. In order to find an optimal LSS solution, thus the right combination of subsystems, the parameters for the definition of the optimization itself have to be determined. The often times used Equivalent Systems Mass (ESM) based trade study approach for life support systems is well suited for phase A conceptual design evaluations. The ESM approach allows an efficient evaluation of LSS on a component or subsystem level. The necessary next step in the process is the design, evaluation and optimization of the LSS on a system level. For the system level LSS design a classic ESM-based trade study seems not to be able to provide the information that is necessary to evaluate the concept correctly. Important decisive criteria such as system stability, controllability and effectiveness are not represented in the ESM approach. These parameters directly and decisively impact the scientific efficiency of the crew, thereby the mission in total. Thus, for system level optimization these criteria must be included alongside the ESM in a new integral optimization method. In order to be able to apply such an integral criterion dynamic modeling of most involved LSS subsystems, especially of the human crew, is necessary. Only then the required information about the efficiency of the LSS, over time, e.g. the systems stability, becomes available. In an effort to establish a dynamic simulation environment for habitats in extreme environmental conditions, the "Virtual Habitat" tool is being developed by the Human Spaceflight Group of the Technische Universit¨t M¨nchen (TUM). The paper discussed here presents the concept of a u the virtual habitat simulation. It discusses in what way the simulation tool enables a prediction of system characteristics and required information demanded by an integral optimization criterion. In general the

  7. Realisation of an anode supported planar SOFC system

    Energy Technology Data Exchange (ETDEWEB)

    Buchkremer, H.P.; Stoever, D. [Institut fuer Werkstoffe der Energietechnik, Juelich (Germany); Diekmann, U. [Zentralabteilung Technologie, Juelich (Germany)] [and others

    1996-12-31

    Lowering the operating temperature of S0FCs to below 800{degrees}C potentially lowers production costs of a SOFC system because of a less expensive periphery and is able to guarantee sufficient life time of the stack. One way of achieving lower operating temperatures is the development of new high conductive electrolyte materials. The other way, still based on state-of-the-art material, i.e. yttria-stabilized zirconia (YSZ) electrolyte, is the development of a thin film electrolyte concept. In the Forschungszentrum Julich a program was started to produce a supported planar SOFC with an YSZ electrolyte thickness between 10 to 20 put. One of the electrodes, i.e. the anode, was used as support, in order not to increase the number of components in the SOFC. The high electronic conductivity of the anode-cermet allows the use of relatively thick layers without increasing the cell resistance. An additional advantage of the supported planar concept is the possibility to produce single cells larger than 10 x 10 cm x cm, that is with an effective electrode cross area of several hundred cm{sup 2}.

  8. Melissa: The European project of closed life support system

    Science.gov (United States)

    Lasseur, Ch.; Paillé, C.; Lamaze, B.; Rebeyre, P.; Rodriguez, A.; Ordonez, L.; Marty, F.

    The MELISSA Micro-Ecological Life Support Alternative project was initiated in 1989 It is intended as a tool to gain understanding of closed life support as well as the development of the technology for a future life support system for long term manned space missions e g a lunar base or a mission to Mars The collaboration was established through a Memorandum of Understanding and is managed by ESA It involves several independent organisations University of Ghent EPAS SCK VITO B University of Clermont Ferrand SHERPA F University Autonoma of Barcelona E University of Guelph CND It is co-funded by ESA the MELISSA partners the Belgian DWTC the Spanish CIRIT and CICYT and the Canadian CRESTech CSA authorities The driving element of MELISSA is the production of food water and oxygen from organic waste inedible biomass CO 2 faeces urea Based on the principle of an aquatic ecosystem MELISSA process comprises 5 compartments from the anoxygenic fermenter up to the photosynthetic one algae and higher plants The choice of this compartmentalised structure is required by the very high level of safety requirements and justified by the need of an engineering approach and to build deterministic control strategy During the past 15 years of research and development a very progressive approach has been developed to understand and control the MELISSA loop This approach starts from the selection of processes their characterisation and mathematical modelling the validation of the control strategy up to the

  9. Incentive Systems That Support Sustainability: A First Nations Example

    Directory of Open Access Journals (Sweden)

    Ronald L. Trosper

    1998-12-01

    Full Text Available Prior to contact with European settlers, the incentive and governance systems used by First Nations peoples of the Northwest coast of North America provided more sustainable use of the fisheries and other resources of that region than did subsequent systems. This paper explores the major reason for that success: the requirements of the potlatch system that chiefs share their income with each other. Because chiefs controlled well-defined territories and subjected each other to review, the potlatch governance system embodied the characteristics of negative feedback, coordination, resiliency, and robustness that political scientist John Dryzek identifies as means to support ecological rationality in the management of ecosystems. This ecological rationality occurs because the sharing of income made chiefs aware of the effects that their actions had on the income of other chiefs. In addition, public discussions that occurred at feasts would allow chiefs to coordinate their actions as needed. The paper concludes with proposals for application of the potlatch system to modern circumstances. Such application means changing the rules for the distribution of income from using ecosystem resources so that all entities share their surplus income with each other. The potlatch system can be applied to modern organizations by noting that chief executive officers are like chiefs, that profit is like surplus income, and that corporations can be viewed as similar to the houses of the traditional Northwest systems. One major change is that profit is no longer privately owned, and must be shared with other organizations that use an ecosystem. Although controls on behavior mandated by state power would be reduced, a modernized potlatch system would still need to operate within a context provided by governments and international agreements.

  10. FY07 Summary of System Interface and Support Systems R&D and Technical Issues Map

    Energy Technology Data Exchange (ETDEWEB)

    Steven R. Sherman

    2007-09-01

    This document provides a summary of research and development activities in the System Interface and Support Systems area of the DOE Nuclear Hydrogen Initiative in FY 2007. Project cost and performance data obtained from the PICS system, at least up through July 2007, are presented and analyzed. Brief summaries of accomplishments and references are provided. A mapping of System Interface and Support Systems technical issues versus the work performed is updated and presented. Lastly, near-term research plans are described, and recommendatioins are provided for additional research.

  11. FY 06 Status of System Interface and Support Systems R&D Areas

    Energy Technology Data Exchange (ETDEWEB)

    S.R. Sherman

    2006-09-01

    This document provides a summary of research and development activities performed in the Systems Interface and Support Systems area of the DOE Nuclear Hydrogen Initiative during FY 2006. Project cost and performance data obtained from the PICS system are presented and analyzed. Brief summaries of accomplishments and references are provided. A mapping of System Interface and Support Systems technical issues versus the work performed is updated and presented. Lastly, near-term research plans are given, and a description of the new UNLV high temperature heat exchanger program structure is provided.

  12. Architecture and life support systems for a rotating space habitat

    Science.gov (United States)

    Misra, Gaurav

    Life Support Systems are critical to sustain human habitation of space over long time periods. As orbiting space habitats become operational in the future, support systems such as atmo-sphere, food, water etc. will play a very pivotal role in sustaining life. To design a long-duration space habitat, it's important to consider the full gamut of human experience of the environment. Long-term viability depends on much more than just the structural or life support efficiency. A space habitat isn't just a machine; it's a life experience. To be viable, it needs to keep the inhabitants satisfied with their condition. This paper provides conceptual research on several key factors that influence the growth and sustainability of humans in a space habitat. Apart from the main life support system parameters, the architecture (both interior and exterior) of the habitat will play a crucial role in influencing the liveability in the space habitat. In order to ensure the best possible liveability for the inhabitants, a truncated (half cut) torus is proposed as the shape of the habitat. This structure rotating at an optimum rpm will en-sure 1g pseudo gravity to the inhabitants. The truncated torus design has several advantages over other proposed shapes such as a cylinder or a sphere. The design provides minimal grav-ity variation (delta g) in the living area, since its flat outer pole ensures a constant gravity. The design is superior in economy of structural and atmospheric mass. Interior architecture of the habitat addresses the total built environment, drawing from diverse disciplines includ-ing physiology, psychology, and sociology. Furthermore, factors such as line of sight, natural sunlight and overhead clearance have been discussed in the interior architecture. Substantial radiation shielding is also required in order to prevent harmful cosmic radiations and solar flares from causing damage to inhabitants. Regolith shielding of 10 tons per meter square is proposed for the

  13. Global Positioning System: Political Support, Directions of Development, and Expectations

    Directory of Open Access Journals (Sweden)

    Krzysztof Czaplewski

    2015-06-01

    Full Text Available Over the last decade the Global Positioning System has become a global, multifunctional tool which provides services that are an integral part of U.S. national security as well as the security of other highly developed countries. Economic development, transport security as well as homeland security are important elements of the global economic infrastructure. In 2000 the United States acknowledged the growing significance of GPS for civilian users and stopped intentionally degrading accuracy for non-military signals that are known as “Selective Availability”. Since then, commercial applications of satellite systems have been proliferating even more rapidly, and therefore, their importance in everyday life has greatly increased. Currently, services that depend on information obtained from the Global Positioning System are the driving force behind economic growth, economic development and the improvement in life safety. This economic development would not be possible without the financial and political support of the US government to maintain the operation of the GPS system. Therefore it is important to have knowledge about the intentions of the US government how system GPS will be developed in the future. Decisions taken in the last 3 months are the subject of this article.

  14. The Initial Development of a Computerized Operator Support System

    Energy Technology Data Exchange (ETDEWEB)

    Roger Lew; Ronald L Boring; Thomas A Ulrich; Ken Thomas

    2014-08-01

    A computerized operator support system (COSS) is a collection of resilient software technologies to assist operators in monitoring overall nuclear power plant performance and making timely, informed decisions on appropriate control actions for the projected plant condition. The COSS provides rapid assessments, computations, and recommendations to reduce workload and augment operator judgment and decision-making during fast- moving, complex events. A prototype COSS for a chemical volume control system at a nuclear power plant has been developed in order to demonstrate the concept and provide a test bed for further research. The development process identified four underlying elements necessary for the prototype, which consist of a digital alarm system, computer-based procedures, piping and instrumentation diagram system representations, and a recommender module for mitigation actions. An operational prototype resides at the Idaho National Laboratory (INL) using the U.S. Department of Energy’s (DOE) Light Water Reactor Sustainability (LWRS) Human Systems Simulation Laboratory (HSSL). Several human-machine interface (HMI) considerations are identified and incorporated in the prototype during this initial round of development.

  15. Optoacoustic measurement of central venous oxygenation for assessment of circulatory shock: clinical study in cardiac surgery patients

    Science.gov (United States)

    Petrov, Irene Y.; Prough, Donald S.; Kinsky, Michael; Petrov, Yuriy; Petrov, Andrey; Henkel, S. Nan; Seeton, Roger; Salter, Michael G.; Esenaliev, Rinat O.

    2014-03-01

    Circulatory shock is a dangerous medical condition, in which blood flow cannot provide the necessary amount of oxygen to organs and tissues. Currently, its diagnosis and therapy decisions are based on hemodynamic parameters (heart rate, blood pressure, blood gases) and mental status of a patient, which all have low specificity. Measurement of mixed or central venous blood oxygenation via catheters is more reliable, but highly invasive and associated with complications. Our previous studies in healthy volunteers demonstrated that optoacoustic systems provide non-invasive measurement of blood oxygenation in specific vessels, including central veins. Here we report our first results of a clinical study in coronary artery bypass graft (CABG) surgery patients. We used a medical-grade OPO-based optoacoustic system developed in our laboratory to measure in real time blood oxygenation in the internal jugular vein (IJV) of these patients. A clinical ultrasound imaging system (GE Vivid e) was used for IJV localization. Catheters were placed in the IJV as part of routine care and blood samples taken via the catheters were processed with a CO-oximeter. The optoacoustic oxygenation data were compared to the CO-oximeter readings. Good correlation between the noninvasive and invasive measurements was obtained. The results of these studies suggest that the optoacoustic system can provide accurate, noninvasive measurements of central venous oxygenation that can be used for patients with circulatory shock.

  16. An Integrated Information Retrieval Support System for Campus Network

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    This paper presents a new integrated information retrieval support system (IIRSS) which can help Web search engines retrieve cross-lingual information from heterogeneous resources stored in multi-databases in Intranet. The IIRSS, with a three-layer architecture, can cooperate with other application servers running in Intranet. By using intelligent agents to collect information and to create indexes on-the-fly, using an access control strategy to confine a user to browsing those accessible documents for him/her through a single portal, and using a new cross-lingual translation tool to help the search engine retrieve documents, the new system provides controllable information access with different authorizations, personalized services, and real-time information retrieval.

  17. Effective Presentation Speech Support System for Representing Emphasis-Intention

    Directory of Open Access Journals (Sweden)

    Tomoko Kojiri

    2015-12-01

    Full Text Available A research presentation integrates slides and speech. If these two aspects do not represent the same intention, the presentation will probably fail to effectively explain the presenter’s intention. This paper focuses on the representation of the critical contents in a presentation. In an effective speech, the speaker adds more intonation and stress to emphasize the importance of the slide contents. Audiences recognize that important contents are those that are explained in a stronger voice or that are said after a short pause. However, in ineffective speeches, such voice effects do not always correspond to the important contents that are indicated by slides. On slides, the important contents are represented by levels of text indentation and size, color, and animation. This research develops a presentation speech support system that estimates important contents from slides and voices that might be recognized by audiences and extracts numerical differences. In addition, the system provides comments and feedback to improve speeches.

  18. Thoracoscopic surgery support system using passive RFID marker.

    Science.gov (United States)

    Takahata, Hiromi; Kojima, Fumitsugu; Okada, Minoru; Sugiura, Tadao; Sato, Toshihiko; Oshiro, Osamu

    2012-01-01

    This paper proposes a RFID based thoracoscopic surgery support system, which is capable of marking a tumor inside organ tissue. The marker composed of small RFID-tags is implanted in the vicinity of tumor found in the endoscopy test. In the thoracoscopic surgery operation for removing the tumor, an RFID detector determines the accurate position of the implanted RFID-tag markers by measuring the strength of the signal emitted from the target tag. Due to limitation in the size of RFID-tag, the proposed system employs a passive RFID. To activate the passive tag implanted in the organ tissue, this paper designs a saddle-shape efficient power supply antenna. A sensitive and frequency-selective receiver is then designed for detecting the weak signal from the tag. The feasibility test confirms that the proposed method is capable of determining the accurate location of RFID tags implanted in the patient's organ tissue.

  19. A hybrid decision support system for iron ore supply

    Directory of Open Access Journals (Sweden)

    A. Samolejová

    2012-01-01

    Full Text Available Many European metallurgical companies are forced to import iron ore from remote destinations. For these companies it is necessary to determine the amount of iron ore that will have to be ordered and to create such a delivery schedule so that the continuous operation of blast-furnace plant is not disrupted and there is no exceedingly large stock of this raw material. The objective of this article is to design the decision support system for iron ore supply which would effi ciently reduce uncertainty and risk of that decision-making. The article proposes a hybrid intelligent system which represents a combination of diff erent artifi cial intelligence methods with dynamic simulation technique for that purpose.

  20. Building a financial decision support system with Oracle

    CERN Document Server

    Angberg, M

    2001-01-01

    CERN (European Organization for Nuclear Research) is the world's leading particle physics research laboratory. It is a truly global organization, collaborating with more than 500 research institutes around the world. The laboratory is currently working on the construction of its largest and most complex scientific instrument ever, the Large Hadron Collider (LHC), due for completion in 2007. Under the current economic climate, however, the laboratory, along with many other businesses and organizations, is having to face shrinking resources and reduced staff levels. Since CERN is expected to continue to grow, it will be forced to achieve higher productivity with fewer resources. In the area of administrative information systems, the situation described above led us to the decision to use Oracle's Data Warehousing concepts and J2EE for the implementation of a scalable and flexible financial decision support system with a low maintenance cost. This paper outlines the experiences drawn from this implementation, fr...

  1. Clinical decision support systems: data quality management and governance.

    Science.gov (United States)

    Liaw, Siaw-Teng

    2013-01-01

    This chapter examines data quality management (DQM) and information governance (IG) of electronic decision support (EDS) systems so that they are safe and fit for use by clinicians and patients and their carers. This is consistent with the ISO definition of data quality as being fit for purpose. The scope of DQM & IG should range from data creation and collection in clinical settings, through cleaning and, where obtained from multiple sources, linkage, storage, use by the EDS logic engine and algorithms, knowledge base and guidance provided, to curation and presentation. It must also include protocols and mechanisms to monitor the safety of EDS, which will feedback into DQM & IG activities. Ultimately, DQM & IG must be integrated across the data cycle to ensure that the EDS systems provide guidance that leads to safe and effective clinical decisions and care.

  2. Development of Operation Support System for Coal Gasifier

    Science.gov (United States)

    Tokoro, Ken-Ichi; Watanabe, Hiroaki; Watanabe, Isamu; Hara, Saburo

    IGCC (Integrated Gasification Combined Cycle) is expected to be one of the major power generating systems in the next generation. However, there are a number of problems to be solved before IGCC is fit for commercial use. One such problem is that of establishing the operation technology of the gasifier. The operation technology of the gasifier is indispensable to achieving a good balance between efficiency and availability. However this operation technology has yet to be established. We therefore developed an operation support system that finds the optimal control parameters of the gasifier, i.e. air ratio and coal feeding ratio, that maximize a calorific value of syngas, and maintain an adequate combustor temperature.

  3. Design of Intelligent Network Performance Analysis Forecast Support System

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    A system designed for supporting the network performance analysis and forecast effort is pre sented, based on the combination of offline network analysis and online real-time performance forecast. The off-line analysis will perform analysis of specific network node performance, correlation analysis of relative network nodes performance and evolutionary mathematical modeling of long-term network performance mea surements. The online real-time network performance forecast will be based on one so-called hybrid predic tion modeling approach for short-term network performance prediction and trend analysis. Based on the module design, the system proposed has good intelligence, scalability and self-adaptability, which will offer highly effective network performance analysis and forecast tools for network managers, and is one ideal sup port platform for network performance analysis and forecast effort.

  4. Exploration Clinical Decision Support System: Medical Data Architecture

    Science.gov (United States)

    Lindsey, Tony; Shetye, Sandeep; Shaw, Tianna (Editor)

    2016-01-01

    The Exploration Clinical Decision Support (ECDS) System project is intended to enhance the Exploration Medical Capability (ExMC) Element for extended duration, deep-space mission planning in HRP. A major development guideline is the Risk of "Adverse Health Outcomes & Decrements in Performance due to Limitations of In-flight Medical Conditions". ECDS attempts to mitigate that Risk by providing crew-specific health information, actionable insight, crew guidance and advice based on computational algorithmic analysis. The availability of inflight health diagnostic computational methods has been identified as an essential capability for human exploration missions. Inflight electronic health data sources are often heterogeneous, and thus may be isolated or not examined as an aggregate whole. The ECDS System objective provides both a data architecture that collects and manages disparate health data, and an active knowledge system that analyzes health evidence to deliver case-specific advice. A single, cohesive space-ready decision support capability that considers all exploration clinical measurements is not commercially available at present. Hence, this Task is a newly coordinated development effort by which ECDS and its supporting data infrastructure will demonstrate the feasibility of intelligent data mining and predictive modeling as a biomedical diagnostic support mechanism on manned exploration missions. The initial step towards ground and flight demonstrations has been the research and development of both image and clinical text-based computer-aided patient diagnosis. Human anatomical images displaying abnormal/pathological features have been annotated using controlled terminology templates, marked-up, and then stored in compliance with the AIM standard. These images have been filtered and disease characterized based on machine learning of semantic and quantitative feature vectors. The next phase will evaluate disease treatment response via quantitative linear

  5. DECISIONS, METHODS AND TECHNIQUES RELATED TO DECISION SUPPORT SYSTEMS (DSS

    Directory of Open Access Journals (Sweden)

    Boghean Florin

    2015-07-01

    Full Text Available Generalised uncertainty, a phenomenon that today’s managers are facing as part of their professional experience, makes it impossible to anticipate the way the business environment will evolve or what will be the consequences of the decisions they plan to implement. Any decision making process within the company entails the simultaneous presence of a number of economic, technical, juridical, human and managerial variables. The development and the approval of a decision is the result of decision making activities developed by the decision maker and sometimes by a decision support team or/and a decision support system (DSS. These aspects related to specific applications of decision support systems in risk management will be approached in this research paper. Decisions in general and management decisions in particular are associated with numerous risks, due to their complexity and increasing contextual orientation. In each business entity, there are concerns with the implementation of risk management in order to improve the likelihood of meeting objectives, the trust of the parties involved, increase the operational safety and security as well as the protection of the environment, minimise losses, improve organisational resilience in order to diminish the negative impact on the organisation and provide a solid foundation for decision making. Since any business entity is considered to be a wealth generator, the analysis of their performance should not be restricted to financial efficiency alone, but will also encompass their economic efficiency as well. The type of research developed in this paper entails different dimensions: conceptual, methodological, as well as empirical testing. Subsequently, the conducted research entails a methodological side, since the conducted activities have resulted in the presentation of a simulation model that is useful in decision making processes on the capital market. The research conducted in the present paper

  6. System of marketing deciding support based on game theory

    Directory of Open Access Journals (Sweden)

    Gordana Dukić

    2008-12-01

    Full Text Available Quantitative methods and models can be applied in numerous spheres of marketing deciding. The choice of optimal strategy in product advertising is one of the problems that the marketing-management often meets. The use of models developed within the framework of game theory makes significantly easier to find out the solutions of conflict situations that appear herewith. The system of deciding support presented in this work is based on the supposition that two opposed sides take part in the game. With the aim of deciding process promotion, the starting model incorporates computer simulation of percentile changes in the market share that represent elements of payment matrix. The supposition is that the random variables that represent them follow the normal division. It is necessary to carry out the evaluation of their parameters because of relevant data. Information techniques, computer and the adequate program applications take the special position in solving and analysis of the suggested model. This kind of their application represents the basic characteristic of the deciding support system.

  7. A Decision Support System for Concrete Bridge Maintenance

    Science.gov (United States)

    Rashidi, Maria; Lemass, Brett; Gibson, Peter

    2010-05-01

    The maintenance of bridges as a key element in transportation infrastructure has become a major concern for asset managers and society due to increasing traffic volumes, deterioration of existing bridges and well-publicised bridge failures. A pivotal responsibility for asset managers in charge of bridge remediation is to identify the risks and assess the consequences of remediation programs to ensure that the decisions are transparent and lead to the lowest predicted losses in recognized constraint areas. The ranking of bridge remediation treatments can be quantitatively assessed using a weighted constraint approach to structure the otherwise ill-structured phases of problem definition, conceptualization and embodiment [1]. This Decision Support System helps asset managers in making the best decision with regards to financial limitations and other dominant constraints imposed upon the problem at hand. The risk management framework in this paper deals with the development of a quantitative intelligent decision support system for bridge maintenance which has the ability to provide a source for consistent decisions through selecting appropriate remediation treatments based upon cost, service life, product durability/sustainability, client preferences, legal and environmental constraints. Model verification and validation through industry case studies is ongoing.

  8. Implementing a decision support system (DSS in e-business

    Directory of Open Access Journals (Sweden)

    Alexandra Ruiz G.

    2010-05-01

    Full Text Available Decision support systems (DSS and e-business (EB have emerged as separate areas. However, currently, and for some years now, DSS and EB have become merged to provide customers with greater benefits and added value. There are different types of DSS and different categories and business models for EB; one area’s applicability to the other thus expands the possible combi- nations which can arise from such different categories. Some representative examples would include auction sites which, through applying intelligent agents, can learn about which products to offer or when and where to sell them; DSS allow a company’s in- formation avilable in web portals for customers and employees to be accessed in a controlled way and decisions thus made; vir- tual stores may be positively affected by data mining and data warehousing being applied; complex algorithms could be used in customer relationship management for predicting and analysing “what would happen if” to identify revenue opportunities in com- petitive markets; and a wide range of other applications where imagination is the limit. Research into DSS / BE must be ongoing due to the constant emergence of new business models and DSS subsystems. Applications can be varied and provide bi-directio- nal support for each one. New interaction mechanisms and efforts to satisfy customers are also the focus of inspiration for new applications for DSS systems in EB.

  9. Development of severe accident management and training support system

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Kwang Sub; Kim, Ko Ryo; Jung, Won Dae; Ha, Jae Joo

    2001-04-01

    Recently, the overall severe accident management strategy is under development according to the logical flow of severe accident management guidelines in some foreign countries. In Korea, the basis of severe accident management strategy is established due to the development of Korean severe accident guideline. In the straining system, the professional information as well as the general information for severe accident should be provided to the related personnel and the function of prior simulation for plant behavior according to strategy execution should be required. Korean severe accident management guideline is chosen as the basis logic for development of support system for decision-support and training related with execution of severe accident strategy. The training simulator is developed for prior expectation of plant behavior and the severe accident computer code, MELCOR, is utilized as the engine, and it is possible to operate equipments necessary for execution of severe accident management guidelines. And also, the graphical interface is developed to provide the plant status and provide status change of major equipments dynamically.

  10. Towards a Decision Support System for Space Flight Operations

    Science.gov (United States)

    Meshkat, Leila; Hogle, Charles; Ruszkowski, James

    2013-01-01

    The Mission Operations Directorate (MOD) at the Johnson Space Center (JSC) has put in place a Model Based Systems Engineering (MBSE) technological framework for the development and execution of the Flight Production Process (FPP). This framework has provided much added value and return on investment to date. This paper describes a vision for a model based Decision Support System (DSS) for the development and execution of the FPP and its design and development process. The envisioned system extends the existing MBSE methodology and technological framework which is currently in use. The MBSE technological framework currently in place enables the systematic collection and integration of data required for building an FPP model for a diverse set of missions. This framework includes the technology, people and processes required for rapid development of architectural artifacts. It is used to build a feasible FPP model for the first flight of spacecraft and for recurrent flights throughout the life of the program. This model greatly enhances our ability to effectively engage with a new customer. It provides a preliminary work breakdown structure, data flow information and a master schedule based on its existing knowledge base. These artifacts are then refined and iterated upon with the customer for the development of a robust end-to-end, high-level integrated master schedule and its associated dependencies. The vision is to enhance this framework to enable its application for uncertainty management, decision support and optimization of the design and execution of the FPP by the program. Furthermore, this enhanced framework will enable the agile response and redesign of the FPP based on observed system behavior. The discrepancy of the anticipated system behavior and the observed behavior may be due to the processing of tasks internally, or due to external factors such as changes in program requirements or conditions associated with other organizations that are outside of

  11. A decision support system for managing forest fire casualties.

    Science.gov (United States)

    Bonazountas, Marc; Kallidromitou, Despina; Kassomenos, Pavlos; Passas, Nikos

    2007-09-01

    Southern Europe is exposed to anthropogenic and natural forest fires. These result in loss of lives, goods and infrastructure, but also deteriorate the natural environment and degrade ecosystems. The early detection and combating of such catastrophes requires the use of a decision support system (DSS) for emergency management. The current literature reports on a series of efforts aimed to deliver DSSs for the management of the forest fires by utilising technologies like remote sensing and geographical information systems (GIS), yet no integrated system exists. This manuscript presents the results of scientific research aiming to the development of a DSS for managing forest fires. The system provides a series of software tools for the assessment of the propagation and combating of forest fires based on Arc/Info, ArcView, Arc Spatial Analyst, Arc Avenue, and Visual C++ technologies. The system integrates GIS technologies under the same data environment and utilises a common user interface to produce an integrated computer system based on semi-automatic satellite image processing (fuel maps), socio-economic risk modelling and probabilistic models that would serve as a useful tool for forest fire prevention, planning and management. Its performance has been demonstrated via real time up-to-date accurate information on the position and evolution of the fire. The system can assist emergency assessment, management and combating of the incident. A site demonstration and validation has been accomplished for the island of Evoia, Greece, an area particularly vulnerable to forest fires due to its ecological characteristics and prevailing wind patterns.

  12. CLIPS based decision support system for Water Distribution Networks

    Directory of Open Access Journals (Sweden)

    S. Kulshrestha

    2011-03-01

    Full Text Available The Water Distribution Networks (WDN are managed by experts, who, over the years of their association and responsibility, acquire an empirical knowledge of the system and, characteristically, this knowledge remains largely confined to their respective personal domains. In the event of any new information and/or emergence of a new problem, these experts apply simple heuristics to design corrective measures and cognitively seek to predict network performance. The human interference leads to inefficient utilization of resources and unfair distribution. Researchers over the past, have tried to address to the problem and they have applied Artificial Intelligence (AI tool to automate the decision process and encode the heuristic rules. The application of AI tool in the field of WDN management is meager. This paper describes a component of an ongoing research initiative to investigate the potential application of artificial intelligence package CLIPS (short for C Language Integrated Production System, developed at NASA/Johnson Space Center in the development of an expert decision support system for management of a water distribution network. The system aims to meet several concerns of modern water utility managers as it attempts to formalize operational and management experiences, and provides a frame work for assisting water utility managers even in the absence of expert personnel.

  13. Decision support system for the operating room rescheduling problem.

    Science.gov (United States)

    van Essen, J Theresia; Hurink, Johann L; Hartholt, Woutske; van den Akker, Bernd J

    2012-12-01

    Due to surgery duration variability and arrivals of emergency surgeries, the planned Operating Room (OR) schedule is disrupted throughout the day which may lead to a change in the start time of the elective surgeries. These changes may result in undesirable situations for patients, wards or other involved departments, and therefore, the OR schedule has to be adjusted. In this paper, we develop a decision support system (DSS) which assists the OR manager in this decision by providing the three best adjusted OR schedules. The system considers the preferences of all involved stakeholders and only evaluates the OR schedules that satisfy the imposed resource constraints. The decision rules used for this system are based on a thorough analysis of the OR rescheduling problem. We model this problem as an Integer Linear Program (ILP) which objective is to minimize the deviation from the preferences of the considered stakeholders. By applying this ILP to instances from practice, we determined that the given preferences mainly lead to (i) shifting a surgery and (ii) scheduling a break between two surgeries. By using these changes in the DSS, the performed simulation study shows that less surgeries are canceled and patients and wards are more satisfied, but also that the perceived workload of several departments increases to compensate this. The system can also be used to judge the acceptability of a proposed initial OR schedule.

  14. A Fuzzy Decision Support System for Management of Breast Cancer

    Directory of Open Access Journals (Sweden)

    Ahmed Abou Elfetouh Saleh

    2011-03-01

    Full Text Available In the molecular era the management of cancer is no more a plan based on simple guidelines. Clinical findings, tumor characteristics, and molecular markers are integrated to identify different risk categories, based on which treatment is planned for each individual case. This paper aims at developing a fuzzy decision support system (DSS to guide the doctors for the risk stratification of breast cancer, which is expected to have a great impact on treatment decision and to minimize individual variations in selecting the optimal treatment for a particular case. The developed system was based on clinical practice of Oncology Center Mansoura University (OCMU. This system has six input variables (Her2, hormone receptors, age, tumor grade, tumor size, and lymph node and one output variable (risk status. The output variable is a value from 1 to 4; representing low risk status, intermediate risk status and high risk status. This system uses Mamdani inference method and simulation applied in MATLAB R2009b fuzzy logic toolbox.

  15. WIPP shaft seal system parameters recommended to support compliance calculations

    Energy Technology Data Exchange (ETDEWEB)

    Hurtado, L.D.; Knowles, M.K. [Sandia National Labs., Albuquerque, NM (United States); Kelley, V.A.; Jones, T.L.; Ogintz, J.B. [INTERA Inc., Austin, TX (United States); Pfeifle, T.W. [RE/SPEC, Inc., Rapid City, SD (United States)

    1997-12-01

    The US Department of Energy plans to dispose of transuranic waste at the Waste Isolation Pilot Plant (WIPP), which is sited in southeastern New Mexico. The WIPP disposal facility is located approximately 2,150 feet (650 m) below surface in the bedded halite of the Salado Formation. Prior to initiation of disposal activities, the Department of Energy must demonstrate that the WIPP will comply with all regulatory requirements. Applicable regulations require that contaminant releases from the WIPP remain below specified levels for a period of 10,000 years. To demonstrate that the WIPP will comply with these regulations, the Department of Energy has requested that Sandia National Laboratories develop and implement a comprehensive performance assessment of the WIPP repository for the regulatory period. This document presents the conceptual model of the shaft sealing system to be implemented in performance assessment calculations conducted in support of the Compliance Certification Application for the WIPP. The model was developed for use in repository-scale calculations and includes the seal system geometry and materials to be used in grid development as well as all parameters needed to describe the seal materials. These calculations predict the hydrologic behavior of the system. Hence conceptual model development is limited to those processes that could impact the fluid flow through the seal system.

  16. IT Security Support for the Spaceport Command Control System Development

    Science.gov (United States)

    Varise, Brian

    2014-01-01

    My job title is IT Security support for the Spaceport Command & Control System Development. As a cyber-security analyst it is my job to ensure NASA's information stays safe from cyber threats, such as, viruses, malware and denial-of-service attacks by establishing and enforcing system access controls. Security is very important in the world of technology and it is used everywhere from personal computers to giant networks ran by Government agencies worldwide. Without constant monitoring analysis, businesses, public organizations and government agencies are vulnerable to potential harmful infiltration of their computer information system. It is my responsibility to ensure authorized access by examining improper access, reporting violations, revoke access, monitor information request by new programming and recommend improvements. My department oversees the Launch Control System and networks. An audit will be conducted for the LCS based on compliance with the Federal Information Security Management Act (FISMA) and The National Institute of Standards and Technology (NIST). I recently finished analyzing the SANS top 20 critical controls to give cost effective recommendations on various software and hardware products for compliance. Upon my completion of this internship, I will have successfully completed my duties as well as gain knowledge that will be helpful to my career in the future as a Cyber Security Analyst.

  17. Intelligent decision support system for home energy retrofit adoption

    Directory of Open Access Journals (Sweden)

    D. Duah

    2016-12-01

    Full Text Available Despite the well-established benefits of home energy retrofits (HER, its adoption has faced huge challenges. Though homeowners typically depend on energy practitioners for HER advice, previous work by the researchers has identified the inadequateness of such information as a barrier. Using an earlier developed information model, an energy retrofit intelligent decision support system (ERIDSS, that integrates expert knowledge with quantitative information to provide homeowners with accurate information for decision-making, was developed. This paper identifies the key components of the proposed ERIDSS, develops rules for relevant energy retrofit expert knowledge to be employed in the knowledge-based system of the proposed ERIDSS, develops the ERIDSS for decision-making for home energy retrofits, and demonstrates the application of the ERIDSS using a pilot system on two test homes. The quantitative information was obtained from published sources and the U.S. Department of Energy’s cost database, and the expert knowledge was obtained through the application of the modified Delphi technique and job shadowing of energy auditors and retrofit contractors. The research contributes to improving the adoption of energy retrofits by homeowners, assisting industry practitioners with the corroboration of knowledge/information they provide to homeowners in order to reduce homeowner bias, providing a good understanding of available implicit domain knowledge through the development of six knowledge-based modules, and the development of a system and approach that may be replicated in other domains.

  18. Postnatal circulatory adaptation in healthy term and preterm neonates.

    Science.gov (United States)

    Evans, N J; Archer, L N

    1990-01-01

    Thirty seven healthy infants (18 born at full term and 19 preterm) were studied serially with cross sectional and Doppler echocardiography to compare their postnatal circulatory adaptation. Pulmonary artery pressure was assessed by its inverse relationship with the ratio of pulmonary artery time to peak velocity and right ventricular ejection time measured from Doppler waveform. Patency of the ductus arteriosus and interatrial shunting were assessed by imaging and Doppler ultrasound. The ratio rose after birth in all infants; it rose more slowly in the preterm infants. After 6 hours of age the mean was significantly less in the preterm group, the greatest difference being between 25 and 36 hours. By 73 to 96 hours the difference was no longer significant. There was a trend towards later ductal closure in the preterm infants but this was not significant. Atrial shunting level varied, but some left to right shunting was seen in all infants satisfactorily studied. Pulmonary artery pressure seems to fall more slowly after preterm birth even in the absence of respiratory problems, but ductal shunting persisting for more than three days is unusual in healthy preterm infants.

  19. Visualization Component of Vehicle Health Decision Support System

    Science.gov (United States)

    Jacob, Joseph; Turmon, Michael; Stough, Timothy; Siegel, Herbert; Walter, patrick; Kurt, Cindy

    2008-01-01

    The visualization front-end of a Decision Support System (DSS) also includes an analysis engine linked to vehicle telemetry, and a database of learned models for known behaviors. Because the display is graphical rather than text-based, the summarization it provides has a greater information density on one screen for evaluation by a flight controller.This tool provides a system-level visualization of the state of a vehicle, and drill-down capability for more details and interfaces to separate analysis algorithms and sensor data streams. The system-level view is a 3D rendering of the vehicle, with sensors represented as icons, tied to appropriate positions within the vehicle body and colored to indicate sensor state (e.g., normal, warning, anomalous state, etc.). The sensor data is received via an Information Sharing Protocol (ISP) client that connects to an external server for real-time telemetry. Users can interactively pan, zoom, and rotate this 3D view, as well as select sensors for a detail plot of the associated time series data. Subsets of the plotted data can be selected and sent to an external analysis engine to either search for a similar time series in an historical database, or to detect anomalous events. The system overview and plotting capabilities are completely general in that they can be applied to any vehicle instrumented with a collection of sensors. This visualization component can interface with the ISP for data streams used by NASA s Mission Control Center at Johnson Space Center. In addition, it can connect to, and display results from, separate analysis engine components that identify anomalies or that search for past instances of similar behavior. This software supports NASA's Software, Intelligent Systems, and Modeling element in the Exploration Systems Research and Technology Program by augmenting the capability of human flight controllers to make correct decisions, thus increasing safety and reliability. It was designed specifically as a

  20. Extracorporeal life support systems: alternative vs. conventional circuits.

    Science.gov (United States)

    Khan, Sameer; Vasavada, Rahul; Qiu, Feng; Kunselman, Allan; Undar, Akif

    2011-05-01

    Emerging technologies and practices for pediatric and neonatal extracorporeal life support (ECLS) are promising. This experiment sought to compare the Medtronic 0800 silicon rubber membrane oxygenator to the Quadrox-iD Pediatric oxygenator in the conventional roller pump circuit, as well as comparing the conventional circuit to an alternative circuit. Three circuits were set up in the experiment. Two conventional roller pump circuits were used to compare the two oxygenators and an alternative circuit consisting of the Quadrox-iD Pediatric oxygenator and Maquet Rotaflow centrifugal pump system was used to identify differences between circuits. All three circuits were primed with Lactated Ringers' solution and human blood, with an hematocrit of 40%. Testing occurred at flow rates of 250, 500, and 750 ml/ min at 37°C for mean arterial line pressures of 60, 80, and 100 mmHg. The results of the experiment showed lower pressure drops and greater retention of total hemodynamic energy (THE) across the Quadrox-iD Pediatric oxygenator compared to the Medtronic 0800 oxygenator. Furthermore, the centrifugal pump used in the alternative circuit showed no back flow at flow rates as low as 250 ml/min while, on the other hand, rpm levels were kept below 2200 for flow rates as high as 750 ml/min. Findings support the usage of the Quadrox-iD Pediatric oxygenator in a circuit utilizing the Maquet Rotaflow centrifugal pump system due to lower pressure drops and greater percentage of THE retained across the circuit. Additional advantages of the alternative circuit include rapid set-up time, easy transport, lower priming volumes, and no gravity-dependent venous drainage system so that it can be situated in close proximity to and at the level of the patient.