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Sample records for cim model

  1. The common information model CIM IEC 61968/61970 and 62325 : a practical introduction to the CIM

    CERN Document Server

    Uslar, Mathias; Rohjans, Sebastian; Trefke, Jörn; Vasquez Gonzalez, Jose Manuel

    2012-01-01

    Within the Smart Grid, the combination of automation equipment, communication technology and IT is crucial. Interoperability of devices and systems can be seen as the key enabler of smart grids. Therefore, international initiatives have been started in order to identify interoperability core standards for Smart Grids.   IEC 62357, the so called Seamless Integration Architecture, is one of these very core standards, which has been identified by recent Smart Grid initiatives and roadmaps to be essential for building and managing intelligent power systems. The Seamless Integration Architecture provides an overview of the interoperability and relations between further standards from IEC TC 57 like the IEC 61970/61968: Common Information Model - CIM.   CIM has proven to be a mature standard for interoperability and engineering; consequently, it is a cornerstone of the IEC Smart Grid Standardization Roadmap. This book provides an overview on how the CIM developed, in which international projects and roadmaps is h...

  2. DISCUTINDO CITY INFORMATION MODELING (CIM E CONCEITOS CORRELATOS

    Directory of Open Access Journals (Sweden)

    Arivaldo Leão de Amorim

    2015-11-01

    Full Text Available Este artigo discute o paradigma City Information Modeling (CIM a partir de uma abordagem ampla, considerando um viés teórico e conceitual deste e de outros termos relacionados. O CIM tem sido apontado por alguns autores como uma extensão do conceito de BIM para o espaço urbano. Contudo, face às características da cidade em relação à edificação isolada e à profusão de conceitos ora em uso, algumas questões precisam ser aprofundadas. Estes conceitos estão intimamente relacionados, apresentando algum tipo de sobreposição, e talvez por isto, sejam confundidos. Assim, pretende-se ampliar a discussão sobre esses conceitos, contribuindo para a utilização dos mesmos e avançando no estabelecimento de uma conceituação e terminologias que facilitem o desenvolvimento das aplicações e a adoção das tecnologias nas práticas relativas ao planejamento, à gestão e ao monitoramento da cidade. Não e tem a pretensão de esgotar o tema, seja pela vastidão das questões envolvidas, seja ainda pelo reduzido espaço a para discussão das mesmas, mas principalmente, porque estas questões estão “em aberto”, sendo objeto de discussões e controvérsias.

  3. 一种CIM模型的Java代码生成方法%Java Code Generation Method of CIM Model

    Institute of Scientific and Technical Information of China (English)

    余永忠; 王永才

    2013-01-01

    介绍一种将CIM模型转换为Java代码的方法。 CIM模型是对电力企业的对象进行建模,是进行CIM应用的基础,将CIM模型转换为Java代码是为了实用的需要。对CIM模型及EMF框架进行简要的介绍,说明CIM模型通过转换为EMF模型从而生成Java代码的方法实现,为CIM模型的落地实用化提供参考。%Introduces a method of transforming CIM model to Java code. CIM model is the model of the power enterprise, is the basis for the CIM application, the CIM model into Java code for practi-cal needs. Gives a brief introduction of CIM model and EMF framework, from the CIM model to EMF model, and generate Java code, as the reference of the CIM model application.

  4. Study on Model for Assessmentof Quality Management Performance of Coal Preparation Plant in CIMS

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    In this paper the method to calculate intangible quality cost is put forward for the first time based on theproduction and management characteristics of coal preparation plant. A model for assessment of quality manage-ment performance of coal preparation plant is established on the ground of quality cost. By using of CIMS integra-tion environment the strategy to carry out the model and the application example are also offered. It provides a newand feasible way to assess performance quality management of coal preparation plant.

  5. CIMS: A FRAMEWORK FOR INFRASTRUCTURE INTERDEPENDENCY MODELING AND ANALYSIS

    Energy Technology Data Exchange (ETDEWEB)

    Donald D. Dudenhoeffer; May R. Permann; Milos Manic

    2006-12-01

    Today’s society relies greatly upon an array of complex national and international infrastructure networks such as transportation, utilities, telecommunication, and even financial networks. While modeling and simulation tools have provided insight into the behavior of individual infrastructure networks, a far less understood area is that of the interrelationships among multiple infrastructure networks including the potential cascading effects that may result due to these interdependencies. This paper first describes infrastructure interdependencies as well as presenting a formalization of interdependency types. Next the paper describes a modeling and simulation framework called CIMS© and the work that is being conducted at the Idaho National Laboratory (INL) to model and simulate infrastructure interdependencies and the complex behaviors that can result.

  6. CIM-EARTH: Community Integrated Model of Economic and Resource Trajectories for Humankind

    Science.gov (United States)

    Foster, I.; Elliott, J.; Munson, T.; Judd, K.; Moyer, E. J.; Sanstad, A. H.

    2010-12-01

    We report here on the development of an open source software framework termed CIM-EARTH that is intended to aid decision-making in climate and energy policy. Numerical modeling in support of evaluating policies to address climate change is difficult not only because of inherent uncertainties but because of the differences in scale and modeling approach required for various subcomponents of the system. Economic and climate models are structured quite differently, and while climate forcing can be assumed to be roughly global, climate impacts and the human response to them occur on small spatial scales. Mitigation policies likewise can be applied on scales ranging from the better part of a continent (e.g. a carbon cap-and-trade program for the entire U.S.) to a few hundred km (e.g. statewide renewable portfolio standards and local gasoline taxes). Both spatial and time resolution requirements can be challenging for global economic models. CIM-EARTH is a modular framework based around dynamic general equilibrium models. It is designed as a community tool that will enable study of the environmental benefits, transition costs, capitalization effects, and other consequences of both mitigation policies and unchecked climate change. Modularity enables both integration of highly resolved component sub-models for energy and other key systems and also user-directed choice of tradeoffs between e.g. spatial, sectoral, and time resolution. This poster describes the framework architecture, the current realized version, and plans for future releases. As with other open-source models familiar to the climate community (e.g. CCSM), deliverables will be made publicly available on a regular schedule, and community input is solicited for development of new features and modules.

  7. CIM-EARTH: Community integrated model of economic and resource trajectories for humankind.

    Energy Technology Data Exchange (ETDEWEB)

    Elliott, J.; Foster, I.; Judd, K.; Moyer, E.; Munson, T.; Univ. of Chicago; Hoover Inst.

    2010-01-01

    Climate change is a global problem with local climatic and economic impacts. Mitigation policies can be applied on large geographic scales, such as a carbon cap-and-trade program for the entire U.S., on medium geographic scales, such as the NOx program for the northeastern U.S., or on smaller scales, such as statewide renewable portfolio standards and local gasoline taxes. To enable study of the environmental benefits, transition costs, capitalization effects, and other consequences of mitigation policies, we are developing dynamic general equilibrium models capable of incorporating important climate impacts. This report describes the economic framework we have developed and the current Community Integrated Model of Economic and Resource Trajectories for Humankind (CIM-EARTH) instance.

  8. Scheme of Application Model Information Sharing Between Control Centers Based on CIM/E%基于CIM/E的电网调度中心应用模型信息共享方案

    Institute of Scientific and Technical Information of China (English)

    辛耀中; 米为民; 蒋国栋; 徐丹丹; 叶飞; 杜鹏

    2013-01-01

    The rapid development of power system requires that the grid models, real-time data and grid graphics information can be synchronously shared in real-time between control centers. The CIM/E standards that have overcome the drawback of low efficiency of CIM/XML and application only in offline exchange are briefly described, being capable of meeting the requirement of grid model online real-time exchange between control centers. Focus of attention is on CIM/E based grid model information integration management, realization of the application of multi-model integration management, offline and online model integration management and multi-level model integration management. Technical support is provided to dispatching business horizontal integration and vertical linkage. CIM/E as well as its associated technology has been applied to the smart grid-operation support system (SG-OSS) for solving the problem of real-time sharing of model information between multiple control centers and various professionals within control centers.%电力系统的快速发展,要求电网模型、实时数据和电网图形等信息在控制中心之间实时共享.文中简单介绍了CIM/E技术标准,该标准克服了原有CIM/XML标准描述效率低且只能应用于离线交换的缺陷,能够满足控制中心之间电网模型在线实时交换的要求.重点研究了基于CIM/E的电网模型信息一体化管理,实现了应用多模型一体化管理、离线与在线模型一体化管理和多级电网模型一体化管理,为电网调度业务横向集成和纵向贯通提供了技术手段.CIM/E及其相关技术已经应用于智能电网调度技术支持系统,解决了调度中心之间及调度中心内部各专业之间的模型信息实时共享问题.

  9. Use of the CIM Ontology

    Energy Technology Data Exchange (ETDEWEB)

    Neumann, Scott; Britton, Jay; Devos, Arnold N.; Widergren, Steven E.

    2006-02-08

    There are many uses for the Common Information Model (CIM), an ontology that is being standardized through Technical Committee 57 of the International Electrotechnical Commission (IEC TC57). The most common uses to date have included application modeling, information exchanges, information management and systems integration. As one should expect, there are many issues that become apparent when the CIM ontology is applied to any one use. Some of these issues are shortcomings within the current draft of the CIM, and others are a consequence of the different ways in which the CIM can be applied using different technologies. As the CIM ontology will and should evolve, there are several dangers that need to be recognized. One is overall consistency and impact upon applications when extending the CIM for a specific need. Another is that a tight coupling of the CIM to specific technologies could limit the value of the CIM in the longer term as an ontology, which becomes a larger issue over time as new technologies emerge. The integration of systems is one specific area of interest for application of the CIM ontology. This is an area dominated by the use of XML for the definition of messages. While this is certainly true when using Enterprise Application Integration (EAI) products, it is even more true with the movement towards the use of Web Services (WS), Service-Oriented Architectures (SOA) and Enterprise Service Buses (ESB) for integration. This general IT industry trend is consistent with trends seen within the IEC TC57 scope of power system management and associated information exchange. The challenge for TC57 is how to best leverage the CIM ontology using the various XML technologies and standards for integration. This paper will provide examples of how the CIM ontology is used and describe some specific issues that should be addressed within the CIM in order to increase its usefulness as an ontology. It will also describe some of the issues and challenges that will

  10. Relation Implementation of CIM Logical Model%CIM逻辑模型的关系实现

    Institute of Scientific and Technical Information of China (English)

    柳文; 柳明

    2011-01-01

    Corresponding to the lack in abilities of storage and query, a relation scheme, which owns the identical representation with CIM logical model, is defined. Those constraints in logical model, which take the form of logical sentences, are transformed into constraints on the cardinal of some related logical relations. With respects to the model access, the DAF interface, which is the basic CIS interface of IEC61970, is realized by relation algebra as an example. Research results show that the efficiencies of query and availability of constraintverification can be acquired by a well choosing relation scheme, while the rich representative ability of logical model is still reserved.%针对逻辑模型在查询和存储方面的不足,定义与其具有一致表示能力的关系模型,并将逻辑模型中以句子形式表示的逻辑约束转化为针对关系模型中逻辑关系的势的约束.根据模型的访问,以IEC61970所采用的数据访问接口DAF为例,在上述关系模型中给出基于关系代数的实现.研究结果表明,通过选择合理的关系模型,可以在保持逻辑模型丰富的表达能力的基础上,利用关系代数提高模型访问的效率,同时保证约束判定的有效性.

  11. "on soft CIMS"-from PDM to CIMS%"软CIMS"论--从PDM到CIMS

    Institute of Scientific and Technical Information of China (English)

    邹恒祺; 杨龙; 陈贵祥

    2000-01-01

    论述了CAPP是信息集成的"关节点",同时提出了符合国情的"软CIMS"概念,并对"软CIMS"的核心技术进行了初步探讨.文中突出按CIM哲理逐步实现符合实际的计算机集成制造系统(CIMS)的思想.

  12. Integrating EMIS in CIMS

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    Enterprise management information system (EMIS) in Manufacturing CIMS Int egrating Platform (MACIP), refers to a computer system that manages the information for running an enterprise. A typ ical EMIS consists of a group of closely connected functions such as production planning, material management, accounting, quality management, etc. The EMIS exc h anges information with the CAD/CAPP system in the design department, and the sho p floor controller (SFC) in the manufacturing department, while the global infor mation system (GIS) of MACIP supplies the mechanism for information sharing with in the enterprise. This paper introduces the EMIS model for a typical manu facturing enterprise, then analyses the interface of the EMIS with the CAD/CAPP system and the SFC. A technical scheme for integrating the EMIS with the GIS is given. This scheme considers the integration of some MRPII systems in the marke t, and adopts advanced industrial standards to ensure its flexibility and reusab ility.

  13. Pressure drop in CIM disk monolithic columns.

    Science.gov (United States)

    Mihelic, Igor; Nemec, Damjan; Podgornik, Ales; Koloini, Tine

    2005-02-11

    Pressure drop analysis in commercial CIM disk monolithic columns is presented. Experimental measurements of pressure drop are compared to hydrodynamic models usually employed for prediction of pressure drop in packed beds, e.g. free surface model and capillary model applying hydraulic radius concept. However, the comparison between pressure drop in monolith and adequate packed bed give unexpected results. Pressure drop in a CIM disk monolithic column is approximately 50% lower than in an adequate packed bed of spheres having the same hydraulic radius as CIM disk monolith; meaning they both have the same porosity and the same specific surface area. This phenomenon seems to be a consequence of the monolithic porous structure which is quite different in terms of the pore size distribution and parallel pore nonuniformity compared to the one in conventional packed beds. The number of self-similar levels for the CIM monoliths was estimated to be between 1.03 and 2.75.

  14. Describing Earth system simulations with the Metafor CIM

    Directory of Open Access Journals (Sweden)

    B. N. Lawrence

    2012-11-01

    Full Text Available The Metafor project has developed a common information model (CIM using the ISO19100 series formalism to describe numerical experiments carried out by the Earth system modelling community, the models they use, and the simulations that result. Here we describe the mechanism by which the CIM was developed, and its key properties. We introduce the conceptual and application versions and the controlled vocabularies developed in the context of supporting the fifth Coupled Model Intercomparison Project (CMIP5. We describe how the CIM has been used in experiments to describe model coupling properties and describe the near term expected evolution of the CIM.

  15. Describing Earth System Simulations with the Metafor CIM

    Directory of Open Access Journals (Sweden)

    B. N. Lawrence

    2012-06-01

    Full Text Available The Metafor project has developed a Common Information Model (CIM using the ISO1900 series formalism to describe the sorts of numerical experiments carried out by the earth system modelling community, the models they use, and the simulations that result. Here we describe the mechanism by which the CIM was developed, and its key properties. We introduce the conceptual and application versions and the controlled vocabularies developed in the context of supporting the fifth Coupled Model Intercomparison Project (CMIP5. We describe how the CIM has been used in experiments to describe model coupling properties and describe the near term expected evolution of the CIM.

  16. Describing Earth system simulations with the Metafor CIM

    Science.gov (United States)

    Lawrence, B. N.; Balaji, V.; Bentley, P.; Callaghan, S.; DeLuca, C.; Denvil, S.; Devine, G.; Elkington, M.; Ford, R. W.; Guilyardi, E.; Lautenschlager, M.; Morgan, M.; Moine, M.-P.; Murphy, S.; Pascoe, C.; Ramthun, H.; Slavin, P.; Steenman-Clark, L.; Toussaint, F.; Treshansky, A.; Valcke, S.

    2012-11-01

    The Metafor project has developed a common information model (CIM) using the ISO19100 series formalism to describe numerical experiments carried out by the Earth system modelling community, the models they use, and the simulations that result. Here we describe the mechanism by which the CIM was developed, and its key properties. We introduce the conceptual and application versions and the controlled vocabularies developed in the context of supporting the fifth Coupled Model Intercomparison Project (CMIP5). We describe how the CIM has been used in experiments to describe model coupling properties and describe the near term expected evolution of the CIM.

  17. Recent advances in CIM technology

    Directory of Open Access Journals (Sweden)

    Zlatkov B.S.

    2008-01-01

    Full Text Available In this article the PIM (Powder Injection Moulding technology is described in brief. After that the benefits and advantages were analyzed and summarized. Ceramic injection moulding (CIM process was analyzed in more detail: CIM- alumina, CIM-zirconia and CIM ferrites as the most common technical ceramics in CIM ceramic parts production, medical applications and accessories in chemical laboratories, and cores in electronic inductive components. After that our results for CIM barium hexaferrite and piezo ceramics (barium titanate are given. The main powder characteristics, the shrinkage and density and the main electrical characteristics of the sintered samples were compared for the isostatically pressed PM (powder metallurgy and CIM formed samples. SEM fractographs of CIM and PM samples are given for CIM green parts, debinded (white parts and sintered parts, and PM green parts and sintered parts. The results obtained were compared to literature data before they were applied in ceramic components production.

  18. The backbone of a City Information Model (CIM): Implementing a spatial data model for urban design

    NARCIS (Netherlands)

    Gil, J.A.; Almeida, J.; Duarte, J.P.

    2011-01-01

    We have been witnessing an increased interest in a more holistic approach to urban design practice and education. In this paper we present a spatial data model for urban design that proposes the combination of urban environment feature classes with design process feature classes. This data model is

  19. Closed incision management with negative pressure wound therapy (CIM): biomechanics.

    Science.gov (United States)

    Wilkes, Robert Peyton; Kilpad, Deepak V; Zhao, Yabin; Kazala, Richard; McNulty, Amy

    2012-03-01

    A novel closed incision management with negative pressure wound therapy (CIM) has been developed for convenient use with closed incisions that has the potential to be beneficial for patients at risk for postoperative complications. Incisions are typically under lateral tension. This study explored the biomechanical mechanisms by which integrity of the incisional closure is enhanced by CIM. CIM was hypothesized to affect local stresses around closed incisions in a beneficial manner. Finite element analyses (FEA) indicated that application of CIM decreased the lateral stresses ~50% around the incision and changed the direction of the stresses to a distribution that is typical of intact tissue. Bench evaluations corroborated findings that CIM significantly increased the force required to disrupt the closed incision by ~50% as compared with closure alone. In conclusion, using 2 FEAs and bench modeling, CIM was shown to reduce and normalize tissue stresses and bolster appositional forces at the incision.

  20. CORBA Based CIMS Application Integration

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    Common object request broker architecture (CORBA) provides the framework and the mechanism for distributed object operation. It can also be applied to computer integrated manufacturing system (CIMS) application integration. This paper studies the CIMS information service requirement, presents a CORBA based integration approach including the CORBA based CIM information system architecture and the application integration mechanism, and discusses the relationship between CORBA and the CIM application integration platform.

  1. Study on Integrated Quality Assurance System in CIMS

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Integrated Quality Assurance System (IQAS) is an important part of CIMS.This paper introduces the architecture of IQAS,elaborates the philosophy of quality assurance and quality control in CIMS.A type of function model is proposed.Meanwhile, details of the model are described.

  2. CIM/E 模式版本管理和映射方法%CIM/E Schema of Version Management and Mapping Method

    Institute of Scientific and Technical Information of China (English)

    曹阳; 黄海峰; 梁成辉; 张鸿

    2015-01-01

    随着智能电网的建设,各类智能电网信息系统呈现分布式和异构的特点,要求通过提升信息系统的互操作能力来促进智能电网信息的共享和交互。文中以提升基于电网通用模型描述规范(CIM/E)的智能电网模型信息互操作能力为目标,分析 CIM/E 类定义模板的构成及其对 CIM/E数据的约束、CIM/E 模式扩展方式,研究建立 CIM/E 模式版本管理及 CIM/E 与公共信息模型(CIM)的模式映射体系,实现了电网模型信息互操作中 CIM/E 模式的统一管理及面向应用的灵活扩展。通过基于实际案例的 CIM/E 与 CIM/XML 互转,验证了 CIM/E 模式版本管理和模式映射的有效性,保证了 CIM/E 模式与不断演进的 CIM 版本同步的能力,进一步推动了 CIM/E 标准的国际化推广。%With the development of smart grids,all kinds of smart grid information systems appear to be distributed and heterogeneous,making it necessary to facilitate smart grid information sharing and interaction by enhancing the interoperability of information systems.Aimed at improving the interoperability of CIM/E based smart grid model information,the structure of CIM/E template and its constraints on data and the expansion mode of CIM/E schema are analyzed.And CIM/E schema version management as well as the mapping system between CIM/E and CIM RDF schema is established,while the control and application-oriented flexible expansion of CIM/E schema used in grid model information interoperability is achieved.The effectiveness of CIM/E schema version management and schema mapping is validated through actual mutual conversion between CIM/E and CIM/XML,the ability of synchronizing CIM/E schema with the steadily evolving CIM versions is guaranteed,and the international promotion of CIM/E standard further promoted.

  3. Virtual CIM and Digital Manufacturing

    Institute of Scientific and Technical Information of China (English)

    Sev V.Nagalingam; Grier C.I.Lin

    2006-01-01

    Manufacturing enterprises play an important role in improving the economic environment of a country.Today, the capability to produce high quality products with shorter delivery time and the ability to produce according to the diverse customer requirements has become the characteristics of successful manufacturing industries. Application of intelligent manufacturing systems and Computer integrated manufacturing (CIM) are the most effective methods for overcoming the issues faced by present day manufactures while retaining the employment level and revenue of a country in today's highly competitive global market. With the developments taking place in CIM and its related technologies, the application of CIM in manufacturing enterprises has become a reality from the dream. This paper highlights the historical developments towards automation and the need for CIM systems. Furthermore, it analyses some new terms such as agile manufacturing, digital manufacturing, agent-based manufacturing and others, which have been emerging recently, and argues all these new technologies are the subsystems of CIM. In addition, this paper provides a new direction in CIM to fulfil the emerging challenges in today's global market and to satisfy the emerging need of virtual enterprises in the form of Virtual CIM.

  4. Integrated Quality Information System of CIMS

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    The computer integrated manufacturing system (CIMS), which is called the 21st century's production mode, is the inevitable course of manufacturing industry development. The integrated quality information system (IQIS), which is the essential component of CIMS, will be the powerful assurance to carry out a CIMS project. In this paper, the concept and the system structure and function of IQIS are discussed. The relationship between IQIS and other component systems of CIMS is analyzed.

  5. A situated-Information Motivation Behavioral Skills Model of Care Initiation and Maintenance (sIMB-CIM): an IMB model based approach to understanding and intervening in engagement in care for chronic medical conditions.

    Science.gov (United States)

    Rivet Amico, K

    2011-10-01

    A sizable portion of adults living with chronic medical conditions (CMCs) delay initiation of care or maintain it inconsistently, which has tremendous personal and public costs. However, few explanatory models with high yield for intervention development and implementation have been proposed to date that would help to characterize and support care use for CMCs. A situated Information, Motivation, Behavioral Skills model of Care Initiation and Maintenance (sIMB-CIM) is presented here as an application of the IMB model to medical care use for CMCs. An example of a sIMB model for characterizing and intervening to support maintenance in HIV-care is provided.

  6. 基于CIM/E文件的电网全景建模技术研究%Study on Modeling Technology for Power Grid Panorama Based on CIM/E File

    Institute of Scientific and Technical Information of China (English)

    邓大为; 李可; 陆俊

    2013-01-01

    针对电网进行全景建模需求不断增长的问题,对多个电力自动化专业系统和数据集成技术展开研究,提出一种创建电网全景模型的解决方案.通过电力自动化专业系统提供的模型描述规范语言(common informationmodel,CIM/E)文件中获取子模型数据,利用数据提取、转换和加载(extraction-transformation-loading,ETL)技术将子模型数据抽取、转换并集成到统一的电网全景模型中,解决了直接访问各应用系统数据库会暴露数据库设计及对数据库性能产生影响的问题.

  7. Comprehensive Instructional Management System (CIMS)--Mathematics, 1988-89.

    Science.gov (United States)

    Guerrero, Frank; And Others

    The Comprehensive Instructional Management System (CIMS) Mathematics project is a teacher-developed mathematics curriculum for kindergarten through grade seven. The 1988-89 evaluation focused on (1) the operation and impact of the program in sample of five districts, chosen to provide diverse models of the computer management system, (2) the…

  8. On the Potential of Functional Modeling Extensions to the CIM for Means-Ends Representation and Reasoning

    DEFF Research Database (Denmark)

    Heussen, Kai; Kullmann, Daniel

    2010-01-01

    Engineering is the art of making complicated things work. There are few things an engineer can’t do. Explaining his work to a computer may be one of them. This paper introduces Functional Modeling with Multilevel Flow Models as an information modeling approach that explicitly relates the function...

  9. Public space patterns: Towards a CIM standard for urban public space

    NARCIS (Netherlands)

    Montenegro, N.; Beirao, J.N.; Duarte, J.P.

    2011-01-01

    This paper describes public space patterns (PSP) used as basic elements of the City Information Modelling (CIM) model proposed within a larger research project that aims to develop an urban design support tool.

  10. 基于物联网技术的输变电设备模型的研究%Research and Application of Power Transmission and Transformation Equipment Based on CIM Model and Internet of Thing

    Institute of Scientific and Technical Information of China (English)

    黄炜

    2016-01-01

    输变电设备CIM模型构建是输变电物联网关键技术实施的基础,关系着设备智能管理与其他高级应用的数据交互与共享、业务的变更与增加。本文研究了IEC 61850和基于IEC 61970的CIM模型特点及使用范围,对两种模型统一与映射方法进行了探讨。%Power transmission and transformation equipment CIM model building is a key technology to implement the basis of power transmission and transformation of things, the relationship between the equipment of intelligent management and other advanced applications, business change and increase interaction and sharing data After studied IEC 61850 and IEC 61970 series standard based on IEC 61850 and IEC 61970 CIM model characteristics and use scope, the uniifed two models and mapping methods are discussed in this paper.

  11. 28 CFR 524.72 - CIM assignment categories.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false CIM assignment categories. 524.72 Section..., CLASSIFICATION, AND TRANSFER CLASSIFICATION OF INMATES Central Inmate Monitoring (CIM) System § 524.72 CIM assignment categories. CIM cases are classified according to the following assignments: (a) Witness...

  12. Characterization of CIM monoliths as enzyme reactors.

    Science.gov (United States)

    Vodopivec, Martina; Podgornik, Ales; Berovic, Marin; Strancar, Ales

    2003-09-25

    The immobilization of the enzymes citrate lyase, malate dehydrogenase, isocitrate dehydrogenase and lactate dehydrogenase to CIM monolithic supports was performed. The long-term stability, reproducibility, and linear response range of the immobilized enzyme reactors were investigated along with the determination of the kinetic behavior of the enzymes immobilized on the CIM monoliths. The Michaelis-Menten constant K(m) and the turnover number k(3) of the immobilized enzymes were found to be flow-unaffected. Furthermore, the K(m) values of the soluble and immobilized enzyme were found to be comparable. Both facts indicate the absence of a diffusional limitation in immobilized CIM enzyme reactors.

  13. CIM - A Manufacturing Paradigm (Le CIM - Un Nouveau Modele Industriel),

    Science.gov (United States)

    1986-07-01

    fait la plupart des entreprises , ont affind le module de "Rgvolution industrielle". Nous vivons A l’poque du spdcialiste. Toutefois, le modale de sp...program will serve as an umbrella under which specific projects are planned, financed , managed, and imple- mented. Well defined corporate goals must be...assets. Through an integration of financing strategies an enterprise can focus on capital investment in shared, value-added assets such as databases

  14. Communication System for CIMS Application Integration Platform

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    CIMS has seen the growth of multiple incompatible hardware architectur es, each architecture supporting several incompatible operating systems, and eac h platform operating with various incompatible development tools (e.g., programm ing language compilers, DBMS, etc.) and one or more incompatible graphic user in terfaces. Also, the growth of the Internet, the World-Wide Web, has introduced new dimensio ns of complexity into the development process. All of these must be dealt with a s the application is made workable in a distributed client-server environment. This paper outlines the architecture of a communication system for the CIMS appl ication integration platform. The communication system makes possible the reque st for service across heterogeneous platforms and networks, and provides some co mmon solutions to issues common to CIMS applications.

  15. 28 CFR 524.76 - Appeals of CIM classification.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Appeals of CIM classification. 524.76..., CLASSIFICATION, AND TRANSFER CLASSIFICATION OF INMATES Central Inmate Monitoring (CIM) System § 524.76 Appeals of CIM classification. An inmate may at any time appeal (through the Administrative Remedy Program)...

  16. The Effect of Nutritional Status in the Pathogenesis of Critical Illness Myopathy (CIM).

    Science.gov (United States)

    Ogilvie, Hannah; Larsson, Lars

    2014-05-30

    The muscle wasting and loss of specific force associated with Critical Illness Myopathy (CIM) is, at least in part, due to a preferential loss of the molecular motor protein myosin. This acquired myopathy is common in critically ill immobilized and mechanically ventilated intensive care patients (ICU). There is a growing understanding of the mechanisms underlying CIM, but the role of nutritional factors triggering this serious complication of modern intensive care remains unknown. This study aims at establishing the effect of nutritional status in the pathogenesis of CIM. An experimental ICU model was used where animals are mechanically ventilated, pharmacologically paralysed post-synaptically and extensively monitored for up to 14 days. Due to the complexity of the experimental model, the number of animals included is small. After exposure to this ICU condition, animals develop a phenotype similar to patients with CIM. The results from this study show that the preferential myosin loss, decline in specific force and muscle fiber atrophy did not differ between low vs. eucaloric animals. In both experimental groups, passive mechanical loading had a sparing effect of muscle weight independent on nutritional status. Thus, this study confirms the strong impact of the mechanical silencing associated with the ICU condition in triggering CIM, overriding any potential effects of caloric intake in triggering CIM. In addition, the positive effects of passive mechanical loading on muscle fiber size and force generating capacity was not affected by the nutritional status in this study. However, due to the small sample size these pilot results need to be validated in a larger cohort.

  17. Acquiring competence for shoot development in Arabidopsis: ARR2 directly targets A-type ARR genes that are differentially activated by CIM preincubation.

    Science.gov (United States)

    Che, Ping; Lall, Sonia; Howell, Stephen H

    2008-02-01

    Shoots can be regenerated from roots in Arabidopsis by treating root explants with cytokinin, however, shoot regeneration requires preincubation on callus induction medium (CIM) prior to induction on cytokinin-rich shoot induction medium (SIM). A cytokinin-inducible marker gene, RESPONSE REGULATOR 15 (ARR15), was identified through a "CIM dropout experiment" with similar requirements for CIM preincubation. The requirements for ARR15 contrasted to ARR5, another cytokinin-inducible ARR gene that does not require CIM preincubation. We show here that despite their differences, both ARR5 and ARR15 are direct targets of the transcriptional B-type response regulator, ARR2. This was demonstrated by identifying genes upregulated following beta estradiol induced nuclear relocation of an ARR2-estradiol receptor fusion protein. The differences in CIM preincubation requirements for ARR5 and ARR15 expression indicate an additional layer of control for these A-type ARR genes during SIM incubation. For ARR15, the CIM requirement is a transcriptional effect, because the expression of ARR15 promoter:GUS reporter gene constructs is also affected by CIM preincubation. A testable model is that transcription of ARR15, but not ARR5, is blocked by a repressor and that the effects of the repressor are relieved by CIM preincubation.

  18. The Information Integration of CAPP in CIMS

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    This paper analyzes the flow of the process design an d the fountain of the technique data in a manufacturing enterprise, and discusse s the information flows between CAPP and other systems in CIMS, such as CAD syst em and Enterprise Resource Planning (ERP) system. And then, it discusses the pla ns of information integration between CAPP and CAD, as well as between CAPP and ERP. To design the processes of a product requires the manufacture information, such as blank material and machine tool, which is s...

  19. CORBA Based Information Integration Platform for CIMS

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    A new information integration platform for computer integrated manufacturing system(CIMS) is presented, which is based on agent and CORBA. CORBA enhances the system integration be-cause it is an industry-standard for interoperable, distributed objects across heterogeneous hardware andsoftware platform. Agent technology is used to improve intelligence of integration system. In order to im-plement the information integration platform, we use network integration server to integrate network, de-sign a generic database agent to integrate database, adopt multi-agent based architecture to integrate appli-cation, and utilize wrapper as CORBA object to integrate legacy code.

  20. Scheme of Power Grid Graphics Maintenance and Sharing Based on CIM/G%基于CIM/G的电网图形维护与共享方案

    Institute of Scientific and Technical Information of China (English)

    李伟; 辛耀中; 沈国辉; 黄昆; 曹蓉蓉; 孟鑫; 万书鹏

    2015-01-01

    With the rapid development of power system,the network structure and grid operation is becoming more and more complex with the penetration of new energy resources and increased network size.It”s hard to realize reliable operation of bulk power system depending solely on a single control center,and then it is crucial to enhance coordination among multiple control centers,that is,to implement real-time sharing of network model,real-time data and graphs.This paper introduces the specifications for power system graphic description,CIM/G.The new specifications have overcome the shortcoming of inefficient graphic exchange based on CIM SVG that is only suitable for off-line graphic exchange,and provide a mechanism for panoramic storage,off-line exchange and on-line real-time remote browsing of graphs within a control center as well as between control centers.The specification CIM/G has successfully been applied in the smart grid dispatching and control system,to realize real-time on-line graph access between neighboring control centers or between superior control center and subordinate control center,providing technical support for horizontal integration and vertical interconnection of dispatching business.%介绍了电力系统图形描述规范———CIM/G 技术标准,该标准解决了基于可缩放矢量图形(SVG)交换规范描述效率低且只能应用于离线交换的缺陷。基于 CIM/G 标准,电网图形维护与共享方案实现了控制中心内部和控制中心之间电网图形的全景存储、基于公共信息模型(CIM)自动生成厂站图和在线实时远程浏览等功能。以上功能应用于智能电网调度控制系统,实现了相邻或上下级控制中心之间电网图形的一体化维护和实时在线调阅,为电网调度业务横向集成和纵向贯通提供了技术支持。

  1. 基于CIMS的工艺间模型研究%Research on the In-Process Model Based on CIMS

    Institute of Scientific and Technical Information of China (English)

    韦尧兵; 范彩霞

    2007-01-01

    分析了基于CIMS环境的工艺间模型(In-Process Model, IPM)的功能,论述了建立工艺间模型原理,总结并提出后续的主要研究内容.基于CIMS环境的工艺间模型(In-Process Model, IPM)架起了产品设计和制造的桥梁,有利于实现与其它应用子系统的基于3D特征的有效交流和沟通.

  2. Impact of marketing, information system, modularity, and low-cost solution on the implementation of CIM in SMEs

    Science.gov (United States)

    Marri, Hussain B.; McGaughey, Ronald; Gunasekaran, Angappa

    2000-10-01

    Globalization can have a dramatic impact on manufacturing sector due to the fact that the majority of establishments in this industry are small to medium manufacturing companies. The role of Small and Medium Enterprises (SMEs) in the national economy has been emphasized all over the world, considering their contribution to the total manufacturing output and employment opportunities. The lack of marketing forces to regulate the operation of SMEs has been a fundamental cause of low efficiency for a long time. Computer Integrated Manufacturing (CIM) is emerging as one of the most promising opportunities for shrinking the time delays in information transfer and reducing manufacturing costs. CIM is the architecture for integrating the engineering, marketing and manufacturing functions through information system technologies. SMEs in general have not made full use of new technologies although their investments in CIM technology tended to be wider in scale and scope. Most of the SMEs only focus on the short-term benefit, but overlook a long- term and fundamental development on applications of new technologies. With the help of suitable information systems, modularity and low cost solutions, SMEs can compete in the global market. Considering the importance of marketing, information system, modularity and low cost solutions in the implementation of CIM in SMEs, a model has been developed and studied with the help of an empirical study conducted with British SMEs to facilitate the adoption of CIM. Finally, a summary of findings and recommendations are presented.

  3. Observations and Modeling of the Green Ocean Amazon 2014/15: Hydroxyl Radical (OH) Chemical Ionization Mass Spectrometer (CIMS) Field Campaign Report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Saewung [Univ. of California, Irvine, CA (United States)

    2016-05-01

    The University of California, Irvine, science team (Dr. Saewung Kim, Dr. Roger Seco, Dr. Alex Guenther, and Dr. Jim Smith) deployed a chemical ionization mass spectrometer system for hydroxyl radical (OH) and sulfuric acid quantifications. As part of the GoAmazon 2014/15 field campaign. Hydroxyl radical determines tropospheric oxidation capacity and had been expected to be very low in the pristine rain forest region such as the Brazilian Amazon because of the presence of significant levels of highly reactive biogenic volatile organic compounds and very low levels of NO, which is an OH recycling agent. However, several recent in situ OH observations provided by a laser-induced fluorescence system reported unaccountably high OH concentrations. To address this discrepancy, a series of laboratory and theoretical studies has postulated chemical reaction mechanisms of isoprene that may regenerate OH in photo-oxidation processes. Along with these efforts, potential artifacts on the laser induced fluorescence system from isoprene and its oxidation products also have been explored. Therefore, the first chemical ionization mass spectrometer observations at the U.S. Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) Climate Research Facility’s T3 site in Manacapuru, Brazil, are expected to provide a critical experimental constraint to address uncertainty in constraining oxidation capacity over pristine rain forest environments. In addition, we deployed a National Center for Atmospheric Research (NCAR) proton transfer reaction time-of-flight mass spectrometer to characterize atmospheric volatile organic compound levels, especially isoprene and its oxidation products, which are critical input parameters for box modeling to simulate OH with different isoprene photo-oxidation schemes. As there has been no report on noticeable new particle formation events, our first in situ sulfuric acid observations in the Amazon rain forest were expected to constrain the

  4. Comparison of CIM discs and CPG glass as solid supports for bioanalytical columns used in allergen detection.

    Science.gov (United States)

    Cevdek, Ana; Franko, Mladen

    2010-09-01

    This work presents a comparison of convective interaction media (CIM) and controlled pore glass (CPG) as solid supports for immunoglobulin antibodies used in bioanalytical detection of allergens in foodstuffs. A flow-injection manifold with highly sensitive thermal lens spectrometric detection was used for this purpose. Using beta-lactoglobulin, a milk allergen, as a model analyte, CIM disc supports had a higher linear range (0.2-3.5 microg L(-1)), better reproducibility (intra-day RSD = 1%, inter-day RSD = 10%), lower consumption of reagents, and better immunocolumn stability (1 month, over 240 injections of substrate), while providing comparable LODs (0.1 microg L(-1)). Application of CIM discs as solid supports in immunocolumns for allergen detection enables fast and sensitive screening of allergens in foodstuffs with sample throughput of up to eight samples per hour.

  5. Analysis of quality costs - A critical element in CIM

    Science.gov (United States)

    Unal, Resit; Dean, Edwin B.

    1990-01-01

    Computer integrated manufacturing (CIM) is a cohesive database of manufacturing information, providing an opportunity to track quality costs and measure progress toward their reduction. This paper presents the quality cost concept as an approach to identify, measure and reduce quality costs while improving quality within CIM. The effect of advanced failure prevention methodologies, such as continuous process improvement and the quality engineering methods of Taguchi, on quality and cost, is discussed.

  6. A Description Method of IEC 61850 SCL ScheMa File Based on CIM/E%一种基于CIM/E的IEC 61850 SCL ScheMa文件描述方法

    Institute of Scientific and Technical Information of China (English)

    刁东宇; 翟明玉; 王海峰; 梅德冬

    2016-01-01

    This paper introduces a description method of IEC 61850 SCL Schema file based on CIM/E lan-guage. Class template definition function of CIM/E language is used in this method to define description format of the entity classes and analyze the UML class diagram in the four major parts of the information defined in the SCL language, including communication, substation, IED and data type template. In accordance with the principles of property inheritance and implementation simplification, the method redefines the class descrip-tion format by defining description format of entity classes and generates the IEC 61850 SCL schema file based on CIM/E language for the sake of model unification in substation and dispatching point.%提供了一种基于CIM/E语言的IEC 61850 SCL Schema文件描述方法,该方法采用CIM/E语言的类模板定义功能,自定义实体类描述格式,对SCL语言中主要定义的4部分信息,包括通信类、一次设备类、智能电子设备类、数据类型模板类的UML类图进行类图分析,按照属性继承和简化实现的原则,采用自定义实体类描述格式对其进行再描述,生成基于CIM/E语言描述的IEC 61850 SCL Schema文件,以解决变电站和调度端模型不统一的问题。

  7. CIM's bridge from CADD to CAM: Data management requirements for manufacturing engineering

    Science.gov (United States)

    Ford, S. J.

    1984-01-01

    Manufacturing engineering represents the crossroads of technical data management in a Computer Integrated Manufacturing (CIM) environment. Process planning, numerical control programming and tool design are the key functions which translate information from as engineered to as assembled. In order to transition data from engineering to manufacturing, it is necessary to introduce a series of product interpretations which contain an interim introduction of technical parameters. The current automation of the product definition and the production process places manufacturing engineering in the center of CAD/CAM with the responsibility of communicating design data to the factory floor via a manufacturing model of the data. A close look at data management requirements for manufacturing engineering is necessary in order to establish the overall specifications for CADD output, CAM input, and CIM integration. The functions and issues associated with the orderly evolution of computer aided engineering and manufacturing are examined.

  8. Chemical ionization mass spectrometer (CIMS for ambient measurements of ammonia

    Directory of Open Access Journals (Sweden)

    D. R. Benson

    2010-03-01

    Full Text Available This study describes a chemical ionization mass spectrometer (CIMS for fast response, in-situ measurements for gas phase ammonia. Protonated ethanol ions were used as the ion-molecule reaction reagent. The CIMS sensitivity was estimated to be between 4–25 Hz/pptv with 30% uncertainty. The instrument background was below 1 ppbv and at lowest was 300 pptv. The uncertainty associated with the instrumental background was less than 30 pptv under the optimized experimental conditions. The time response was less than 30 s, and the detection limit was approximately 60 pptv. This CIMS was used to measure the ambient NH3 in Kent, Ohio, for several weeks throughout three seasons. The measured ammonia mixing ratios were usually at the sub-ppbv level, and higher during the spring (200±120 pptv than in the winter (60±75 pptv and fall (150±80 pptv.

  9. Implementing Continuous Improvement Management (CIM) in the Public Schools.

    Science.gov (United States)

    Borgers, William E.; Thompson, Tommy A.

    This book traces the restructuring of a Texas school district that moved from management by coercion to continuous improvement for quality. In 1990, the Dickinson Independent School District (Texas) began implementation of Continuous Improvement Management (CIM), based on the teachings of W. Edwards Deming, William Glasser, and J. M. Juran.…

  10. CIM-Einführungsstrategie für kleinere Betriebe

    OpenAIRE

    2008-01-01

    Aus den Veröffentlichungen über CIM-Projekte geht immer häufiger hervor, dass der von den Anbietern vertretene hohe Anspruch einer umfassenden CIM-Anwendung und die Ergebnisse durchgeführter CIM-Realisierungen in der Praxis nicht übereinstimmen. Es wäre jedoch falsch, aufgrund dieser Beobachtungen die CIM-Strategie als solche in Frage zu stellen. Der Ausweg aus diesem Missstand ist vielmehr über geeignete CIM-Einführungsstrategien zu suchen.

  11. Development of CIMS and FMS in Faults Diagnosis System

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The research and practice of CIMS and FMS has brought about a great development to advanced manufacturing systems for decades. The experience of failure and success during the process of development is a revelation and reference for the design of a fault diagnosis system. This paper focuses on its function of directing to the design of a fault diagnosis system in terms of the flexibility of the system, the human's importance in the system, and the design of a distributed system. In view of the tendency of CIMS and FMS, the article also states the principle that the new fault diagnosis system should be improved by enhancing hardware in software, remote Internet service, and sustainable development.

  12. Confidence Interval Methodology for Ratio Means (CIM4RM)

    Science.gov (United States)

    2010-08-01

    is the combined effort of bootstrapping and creativity in constructing CLs around ratio means. CIM4RM was tested in many ratio mean applications and...for vehicle or repair period man - hours Man-hours per vehicle or repair MR: Estimated maintenance ratio for i th BSS adj MRt Weighted estimated...assumptions on the distributions) and creativity to compute approximate confidence intervals for a ratio mean metric. The bootstrap-t approach is very

  13. The Training and Culture Strategies in the CIMS Subject of China 863 Program(1986-2000)

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Manpower is a key factor for the success of the CIMS Subject of China 863 Program. Many manpower strategies have been used in the CIMS Subject, which include elite strategies, training and practicing strategies, and culture strategies. This paper is mainly about the training and culture strategies such as to pay attention to the training and the practice of the technical team, and to form a fine CIMS culture.

  14. Detection of processed genetically modified food using CIM monolithic columns for DNA isolation.

    Science.gov (United States)

    Jerman, Sergej; Podgornik, Ales; Cankar, Katarina; Cadet, Neza; Skrt, Mihaela; Zel, Jana; Raspor, Peter

    2005-02-11

    The availability of sufficient quantities of DNA of adequate quality is crucial in polymerase chain reaction (PCR)-based methods for genetically modified food detection. In this work, the suitability of anion-exchange CIM (Convective Interaction Media; BIA Separations, Ljubljana, Slovenia) monolithic columns for isolation of DNA from food was studied. Maize and its derivates corn meal and thermally pretreated corn meal were chosen as model food. Two commercially available CIM disk columns were tested: DEAE (diethylaminoethyl) and QA (quaternary amine). Preliminary separations were performed with standard solution of salmon DNA at different pH values and different NaCl concentrations in mobile phase. DEAE groups and pH 8 were chosen for further isolations of DNA from a complex matrix-food extract. The quality and quantity of isolated DNA were tested on agarose gel electrophoresis, with UV-scanning spectrophotometry, and by amplification with real-time PCR. DNA isolated in this way was of suitable quality for further PCR analyses. The described method is also applicable for DNA isolation from processed foods with decreased DNA content. Furthermore, it is more effective and less time-consuming in comparison with the existing proposed methods for isolation of DNA from plant-derived foods.

  15. CIM (Computer Integrated Manufacturing) in Higher Education: A Partnership with IBM.

    Science.gov (United States)

    Andrews, Hans A.; Allen, John

    1992-01-01

    Discusses Illinois Valley Community College's selection as 1 of 48 community colleges operating technology transfer and demonstration centers for computer-integrated manufacturing (CIM) in the IBM-CIM in Higher Education Alliance. Reviews local industry involvement, curriculum development, faculty training, deliverables, and the prognosis for the…

  16. Comprehensive Instructional Management System (CIMS) Communication Arts 1985-86. OEA Evaluation Report.

    Science.gov (United States)

    New York City Board of Education, Brooklyn. Office of Educational Assessment.

    Using both qualitative and quantitative data, the Office of Educational Assessment/Instructional Support Unit evaluated the 1985-1986 New York City Board of Education's Comprehensive Instructional Management Systems-Communication Arts (CIMS-CA) Project. The 1985-1986 CIMS-CA aimed to (1) implement an integrated communication arts program for…

  17. CIM Academy Summer School: A Report of the Evaluation of the 1999 Summer School.

    Science.gov (United States)

    Mitchell, Stephanie; King, Fredrick; Anderson, Gena

    Students in the Portland, Oregon, public schools who achieve the state standards for grade 10 receive a Certificate of Initial Mastery (CIM) to document their achievement. Students who do not meet the standards may continue to be tested throughout their high school years, but they may receive a diploma without achieving a CIM. To offer additional…

  18. Application of two types of CIM tube column for purification of microbial enzymes.

    Science.gov (United States)

    Isobe, Kimiyasu; Kawakami, Yoshimitsu

    2005-02-11

    Chromatography conditions for two types of convection interaction media (CIM) tube monolithic column, DEAE-8 and C4-8, were investigated using three enzymes from different microorganisms. The enzymes were adsorbed on a CIM DEAE-8 tube column under the same conditions as conventional DEAE columns. The CIM C4-8 tube column required a high concentration of ammonium sulfate compared to the conventional C4 column for adsorbing the enzymes. The separation of enzymes on the CIM tube column chromatography was not affected at flow rates between 0.15 and 1.25 volumes of the column per min. Both columns were successfully applied to the purification of enzymes from crude enzyme solution. Thus, both CIM tube monolithic columns proved useful in greatly reducing the purification time, and could be used at any stage of enzyme purification.

  19. A Frame Based Architecture for Information Integration in CIMS

    Institute of Scientific and Technical Information of China (English)

    吴信东

    1992-01-01

    This paper foumulates and architecture for information integration in computer integrated manufacturing systems(CIMS).The architecture takes the frame structure as single link among applications and between applications and physical storage.All the advantages in form features based intgrated systems can be found in the frame-based architecture as the frame structrue here takes from features as its primitives.But other advantage,e.g.,default knowledge and dynamic domain knowledge can be attached to frames and the frame structure is easy to be changed and extended,which cannot be found ing form reatures based systems,can also be showed in frame based architectures as the frame structure is a typical knowledge representation scheme in artificial intelligence and many researches and interests have put on it.

  20. Study on the integration approaches to CAD/CAPP/FMS in garment CIMS

    Science.gov (United States)

    Wang, Xiankui; Tian, Wensheng; Liu, Chengying; Li, Zhizhong

    1995-08-01

    Computer integrated manufacturing system (CIMS), as an advanced methodology, has been applied in many industry fields. There is, however, little research on the application of CIMS in the garment industry, especially on the integrated approach to CAD, CAPP, and FMS in garment CIMS. In this paper, the current situations of CAD, CAPP, and FMS in the garment industry are discussed, and information requirements between them as well as the integrated approaches are also investigated. The representation of the garments' product data by the group technology coding is proposed. Based on the group technology, a shared data base as an integration element can be constructed, which leads to the integration of CAD/CAPP/FMS in garment CIMS.

  1. The Elite Strategies in the CIMS Subject of China 863 Program(1986-2000)

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Manpower is the key factor to the success of the CIMS Subject of China 863 Program. Many manpower strategies have been used in the CIMS Subject, which include elite strategies, training and practicing strategies, and culture strategies. This paper is mainly about the elite strategies such as to discover the talents, to cultivate the elites and to establish the mechanism for the expert groups to work in team, echelon and vigor.

  2. Purification of ß-glucosidases from Pichia etchellsii using CIM monolith columns.

    Science.gov (United States)

    Gaonkar, Roopa K; Mishra, Saroj; Vijayalakshmi, M A

    2011-05-01

    β-Glucosidases (EC 3.2.1.21) are industrially important glycosyl hydrolases used for cellulose saccharification as well as for synthesis of glyco-conjugates. Crystal structure of only one β-glucosidase of family 3 of the glycosyl hydrolase families is available due to difficulty in purification of these closely related enzymes from a given source. Multiple steps used during purification result in low yield, making it difficult to study their properties. Conditions for purification of two closely related β-glucosidases (BGL I and BGL II) of family 3 from Pichia etchellsii were investigated in this study. Two weak anion exchange columns convective interaction media-diethyl amino ethyl (CIM-DEAE) and CIM-ethylenediamine (CIM-EDA) were used for this purpose. The results obtained at 0.34 ml disk (CIM-DEAE) level were scaled up to 8 ml CIM-DEAE tube column wherein BGL I and BGL II were separated from the major contaminants in the cell-free extract. The recovered enzymes were completely resolved in the second step using CIM-EDA. A final specific activity of 9,180 IU/mg and 2,345.3 IU/mg was achieved for BGL I and BGL II respectively with an overall yield of 33%. The system should be applicable to resolution of other closely related enzymes from this family.

  3. Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway.

    Science.gov (United States)

    Bergmann, Frank; Singh, Sandhya; Michel, Sara; Kahlert, Christoph; Schirmacher, Peter; Helmke, Burkhard; Von Knebel Doeberitz, Magnus; Kloor, Matthias; Bläker, Hendrik

    2010-12-01

    Celiac disease (CD) is an inflammatory disorder associated with an increased risk of small bowel adenocarcinoma. Recent studies have demonstrated aberrant CpG island methylation (CIM) in chronic inflammation, aging and cancer. We hypothesized that CIM may link CD to small bowel carcinogenesis. We determined microsatellite instability (MSI), CIM, and expression of MLH1 and MGMT in 3 CD-associated small bowel carcinomas and corresponding non-neoplastic mucosa. The results were compared to those of small bowel mucosa from CD patients without carcinoma and 20 small bowel carcinomas from a non-CD origin. A high level CIM/MSI phenotype was found in all of the 3 CD-associated carcinomas and was associated with loss of MLH1 expression due to hypermethylation of the MLH1 promoter. This phenotype was noted in only 2 of the 20 investigated non-CD-associated carcinomas. Low-level CIM was already detectable in 9 of the 12 non-neoplastic mucosa samples of CD patients and in non-CD-associated carcinomas of elderly patients. In conclusion, our data reveal that the high-level CIM/MSI pathway is typical of CD-associated small bowel carcinomas and indicate that aberrant CpG island methylation links CD and carcinogenesis. The data further suggest that CD should be considered in patients with small bowel adenocarcinoma, particularly when the tumors display MSI.

  4. 源于业务的CIM模型实现通用方法框架%A Common Methodological Framework for Business to CIM Implementation

    Institute of Scientific and Technical Information of China (English)

    郑灶贤; 杜炎

    2014-01-01

    在电力行业,IEC61970/61968 CIM因为可以解决信息孤岛问题而成为当前电力企业进行信息交互的标准并被广泛使用。众所周知IEC CIM模型是一个比较庞大的体系,在应用中都是采取相应范围的裁剪和按照需求进行相应的扩充,我们称之为定制化。由于各个人或厂商对于CIM模型的理解不一致,在裁剪或扩充的时候难免出现诸如实用性、与前版本的一致性和可扩充性等的差异问题。特别是在实践中发现在支持接入不同时期、由不同厂商开发的正在运行的应用系统基于CIM标准的实例化有各自的方式和方法,所以电力企业将面临着不同应用系统采用不同CIM标准版本进行的实例化情况,非常难以管理。为了解决同一个CIM模型标准落地存在差异的问题,介绍一种通过实践融合了业务建模方法(BPMN 2.0)、智能电网系统的需求开发方法论(IEC62559)和IEC通用方法框架CMF的方法框架,从方法论的角度约束或指导CIM模型落地。%In the power industry, IEC61970/61968 CIM which used to solve the problem of information islands for power companies now becomes the standard for information exchange and widely used. Well-known IEC CIM model is a relatively large system, we are taking in the application corresponding scope accordance with the actual needs of the crop and the expansion, we call it customization. As each individual or vendor has different understanding of CIM model, there are many problems such as usability, consistency with the previous version and scalability issues , etc. when cutting or expansion. Especially in implementation, we find that applications developed by different vendors at different times, are running on the instantiation of CIM standards with their own ways and means, the power companies will be faced with different applications using different CIM standards examples of CIM versions, and they are very difficult to

  5. Atmospheric SO{sub 2}. Global measurements using aircraft-based CIMS

    Energy Technology Data Exchange (ETDEWEB)

    Fiedler, V.

    2008-06-27

    Aircraft based measurements of tropospheric sulfur dioxide, SO{sub 2}, have been carried out during four campaigns in South America (TROCCINOX), Australia (SCOUT-O3), Europe (INTEX/MEGAPLUME) and Africa (AMMA). SO{sub 2} has been measured by chemical ionization mass spectrometry (CIMS), permanently online calibrated with isotopically labelled SO{sub 2}. The measurement method is described thoroughly in this work and the measured data are presented. Moreover, the data of the different regions are compared in general and typical air mass situations with SO{sub 2} enhancement are shown. A detailed analysis of four SO{sub 2} pollution plume cases emphasizes the main features: long-range transport, SO{sub 2} from metal smelters/volcanoes or from biomass burning. The SO{sub 2} measurements are analyzed in the light of simultaneously measured trace gas, particle and meteorological data. Air mass trajectory models (FLEXPART or HYSPLIT) are employed for a determination of the pollution origin. Further going evaluations with the aerosol model AEROFOR complete the analyses and point out, that the measured SO{sub 2} mole fractions are sufficient to explain new particle formation and growth. Finally, a first comparison of the measured SO{sub 2} to results from a global circulation model (ECHAM) with implemented sulfur chemistry showed a significant underestimation of the measured SO{sub 2} mole fraction by the model in the free troposphere. (orig.)

  6. Pengelolaan Risiko pada Updating Computer Integrated Manufacturing (CIM di Perusahaan Pakan Ternak

    Directory of Open Access Journals (Sweden)

    Wiwin Widiasih

    2013-03-01

    Full Text Available Risiko adalah kemungkinan terjadinya penyimpangan dari harapan yang dapat menimbulkan kerugian. Pengelolaan risiko yang baik akan memberikan keuntungan bagi perusahaan. Sama dengan pelaksanaan proyek-proyek yang lain, maka updating CIM di perusahaan ini tidak tertutup kemungkinan terjadinya risiko. Maka peneliti akan menerapkan manajemen risiko untuk updating CIM. Penelitian ini bertujuan untuk memberikan gambaran potensi risiko yang muncul ketika melakukan updating pada CIM dan memberikan rekomendasi penanganan risiko untuk proyek serupa di masa akan datang. Pengelolaan risiko dilakukan dengan mengadopsi framework ISO 31000:2009. Pada penelitian ini, konsep implementasi sistem/updating CIM mengadopsi konsep Meyfroidt sebagai kerangka kerja untuk mengidentifikasi risiko. Identifikasi risiko dilakukan dengan berdasarkan pada aktivitas, kemudian risiko yang telah teridentifikasi diklasifikasikan ke dalam empat aspek risiko yaitu technical, human resources, organization and control, dan financial. Risiko yang paling banyak muncul adalah aspek human resources. Penanganan risiko dilakukan dengan mencari hubungan keterkaitan sebab akibat antar risiko ekstrim. Dalam updating CIM selanjutnya, perusahaan perlu memperhatikan aspek human resources karena risiko yang diidentifikasi banyak disebabkan karena kurangnya kompetensi SDM. Selain itu memperhatikan permasalahan dalam hal ketidakakuratan engineering design, koordinasi antar anggota tim, pengiriman alat/mesin oleh supplier, dan kecelakaan kerja.

  7. Evaluation of closed incision management with negative pressure wound therapy (CIM): hematoma/seroma and involvement of the lymphatic system.

    Science.gov (United States)

    Kilpadi, Deepak V; Cunningham, Mark R

    2011-01-01

    The objective of this porcine study was to evaluate the effect of closed incision management with negative pressure wound therapy (CIM) on hematoma/seroma formation, fluid removal into the CIM canister, and involvement of the lymphatic system. In each swine (n = 8), two sets of ventral contralateral subcutaneous dead spaces with overlying sutured incisions were created. Stable isotope-labeled nanospheres were introduced into each subcutaneous dead space. Each contralateral incision was assigned to CIM (continuous -125 mmHg negative pressure) and control (semipermeable film dressing), respectively. Following 4 days of therapy, hematoma/seroma was weighed, total fluid volume in canisters was measured, five pre-identified lymph nodes were harvested, and five key organs were biopsied. There was 25 ± 8 g (standard error [SE]) (63%) less hematoma/seroma in CIM sites compared to control sites (p = 0.002), without any fluid collection in the CIM canister. In lymph nodes, there were ∼60 μg (∼50%) more 30- and 50-nm nanospheres from CIM sites than from control sites (p = 0.04 and 0.05, respectively). There was significantly greater nanosphere incidence from CIM sites than from control sites in lungs, liver, and spleen (p CIM significantly decreased hematoma/seroma levels without fluid collection in the canister, which may be explained by increased lymph clearance.

  8. Application of Convective Interaction Media (CIM) disk monolithic columns for fast separation and monitoring of organic acids.

    Science.gov (United States)

    Vodopivec, M; Podgornik, A; Berovic, M; Strancar, A

    2000-11-01

    The separation of organic acids on the anion-exchange monolithic support, commercially available as Convective Interaction Media (CIM), is presented in this study. It is demonstrated that citric, isocitric, pyruvic, fumaric, malic, and alpha-ketoglutaric acid can be successfully separated using a CIM monolithic column of suitable user-adjustable length. The effect of the mobile phase composition on the separation is investigated. CIM monolithic columns of adjustable length from 3 to 18 mm are compared regarding the resolution and the back pressure. It is shown that the CIM monolithic column of 12 mm in length enables a good separation of all six organic acids within 3 min and exhibits a linear dependence of back pressure versus flow rate. The resolution and the dynamic binding capacity are found to be flow-unaffected. A filtrated sample of bioprocess supernatant is analyzed without previous pretreatment, which indicates the possibility of online monitoring of small molecules during the bioprocess using CIM monolithic columns.

  9. The Development of CIMS and the Actuality of CIMS Application in China%CIMS的发展及其在我国的应用现状

    Institute of Scientific and Technical Information of China (English)

    朱焕立; 刘进宝

    2003-01-01

    介绍了CIMS的产生背景、含义及在我国的发展,指出我国863/CIMS主题实施的CIM/CIMS内涵;总结出了CIMS技术体系,通过介绍863/CIMS应用示范工程概况阐述了CIMS在我国的应用现状.

  10. Social Shaping of CAPM/CIM and the Social System of the Company

    DEFF Research Database (Denmark)

    Clausen, Christian

    1997-01-01

    This chapter deals with the transformation of production technology (CAPM and CIM) from general visions operating in discussions at the societal level or among consultants, unions etc. through to its implementation at the company level. The shaping of technology through political and social proce...

  11. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Part 2, Teacher. Experimental. Level 2.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    The major goal of the Comprehensive Instructional Management System (CIMS) for mathematics is to provide classroom teachers in New York City with a well-structured, objective-based curriculum. This second part of the manual for Level 2 includes modules for 12 topics: numbers and numeration; addition of whole numbers; subtraction of whole numbers;…

  12. CIM Academy Summer School: A Report of the Evaluation of the 2000 Summer School.

    Science.gov (United States)

    King, Fredrick; Kobak, Jared

    The Certificate of Initial Mastery (CIM) Academy summer school in Portland, Oregon, is a public school program that provides additional support to students in grades 5 through 8 who are not meeting state and district standards in reading and mathematics. Summer 2000 was the second year of this program, and this session benefited from the…

  13. Comprehensive Instructional Management Systems (CIMS)--Science 1991-92. OREA Report.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Office of Research, Evaluation, and Assessment.

    The Comprehensive Instructional Management System (CIMS)-Science program is designed to support teachers in teaching the "New York State Elementary Science Syllabus." The curriculum emphasizes a hands-on inquiry approach to learning and includes an assessment component comprised of written tests and performance-based tests, designed to…

  14. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Workbook Part 1, Experimental. Level 2.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    The activities in this workbook are designed to provide pupils with practice in mastering the performance objectives of the Comprehensive Instructional Management System (CIMS) in Mathematics for Level 2, Part 1, in New York City schools. It follows the sequence of the teacher's manual, with the objective number listed on each page. The 85…

  15. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Workbook Part 2, Experimental. Level 2.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    The activities in this mathematics workbook are designed to provide pupils with practice in mastering the performance objectives of Level 2, Part 2, in the Comprehensive Instructional Management System (CIMS) for New York City schools. It follows the sequence of the teacher's manual, with the objective number listed on each page. The 128…

  16. Comprehensive Instructional Management System (CIMS) Science 1988-89. Evaluation Section Report.

    Science.gov (United States)

    Guerrero, Frank; And Others

    This report is designed to help teachers and supervisors in teaching the New York State Elementary Syllabus in kindergarten through grade two. The curriculum emphasized a hands-on inquiry approach, and included both science process skills and content objectives. This is a report of the Comprehensive Instructional Management System (CIMS)-Science…

  17. VTAE CIM Conference (Menomonie, Wisconsin, June 6-7, 1990). Final Report.

    Science.gov (United States)

    Lee, Howard D.

    This document reports on a workshop conducted to bring together vocational, technical, and adult education colleges and the University of Wisconsin-Stout staff members who are working with computer-integrated manufacturing (CIM). Participants discussed current program content, identified areas that need further development, and determined how…

  18. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Part 1, Teacher, Experimental. Level 2.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    The major goal of the Comprehensive Instructional Management System (CIMS) for mathematics is to provide the classroom teacher in New York City with a well-structured, objective-based curriculum. This first part of the manual for Level 2 includes varied numbers of modules for 12 topics: numbers and numeration; addition of whole numbers;…

  19. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Part 1--Teacher. Experimental. Level 6. Revised.

    Science.gov (United States)

    Berman, David; And Others

    The Comprehensive Instructional Management System (CIMS) is a unified mathematics curriculum for grades K-7. The curriculum is cyclical in design, and reflects the most recent New York City and New York State guidelines. Utilizing the experience of classroom teachers, a teacher-designed curriculum was developed that includes a rich selection of…

  20. CIMS Network of Support for Technology Projects%浅谈CIMS工程网络支持技术

    Institute of Scientific and Technical Information of China (English)

    刘婷婷

    2009-01-01

    该文简述了CIMS的组成并探讨了CIMS的重要支持技术CIMS网络,分别对CIMS网络的作用和网络协议作了相应的介入,在此基础上总结了互联网机构的选择等建网技术.%The composition of CIMS and the CIMS network which is the important support technology for CIMS is discussed in this pa-per.On the basis of the intervention of the role of the CIMS network and network protocol,the network building technology such as the choice of the Intemet institutions is summed up.

  1. Dive Activities from Cruise Information Management System (CIMS) for Operation Deep Scope 2005 - Office of Ocean Exploration

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Information about dive activities were recorded into the Cruise Information Management System (CIMS) by the NOAA Office of Ocean Exploration's data manager during...

  2. Dive Activities from Cruise Information Management System (CIMS) for Life on the Edge 2005 - Office of Ocean Exploration

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Information about dive activities were recorded into the Cruise Information Management System (CIMS) by the NOAA Office of Ocean Exploration's data manager during...

  3. Dive Activities from Cruise Information Management System (CIMS) for Life on the Edge 2004 - Office of Ocean Exploration

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Information about dive activities were recorded into the Cruise Information Management System (CIMS) by the NOAA Office of Ocean Exploration's data manager during...

  4. Dive Activities from Cruise Information Management System (CIMS) for Investigating the Charleston Bump 2003 - Office of Ocean Exploration

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Information about dive activities were recorded into the Cruise Information Management System (CIMS) by the NOAA Office of Ocean Exploration's data manager during...

  5. Linagliptin Limits High Glucose Induced Conversion of Latent to Active TGFß through Interaction with CIM6PR and Limits Renal Tubulointerstitial Fibronectin.

    Directory of Open Access Journals (Sweden)

    Muralikrishna Gangadharan Komala

    Full Text Available In addition to lowering blood glucose in patients with type 2 diabetes mellitus, dipeptidyl peptidase 4 (DPP4 inhibitors have been shown to be antifibrotic. We have previously shown that cation independent mannose-6-phosphate receptor (CIM6PR facilitates the conversion of latent to active transforming growth factor β1 (GFß1 in renal proximal tubular cells (PTCs and linagliptin (a DPP4 inhibitor reduced this conversion with downstream reduction in fibronectin transcription.We wanted to demonstrate that linagliptin reduces high glucose induced interaction between membrane bound DPP4 and CIM6PR in vitro and demonstrate reduction in active TGFß mediated downstream effects in a rodent model of type 1 diabetic nephropathy independent of high glycaemic levels.We used human kidney 2 (HK2 cells and endothelial nitric oxide synthase knock out mice to explore the mechanism and antifibrotic potential of linagliptin independent of glucose lowering. Using a proximity ligation assay, we show that CIM6PR and DPP4 interaction was increased by high glucose and reduced by linagliptin and excess mannose-6-phosphate (M6P confirming that linagliptin is operating through an M6P-dependent mechanism. In vivo studies confirmed these TGFß1 pathway related changes and showed reduced fibronectin, phosphorylated smad2 and phosphorylated smad2/3 (pSmad2/3 with an associated trend towards reduction in tubular atrophy, which was independent of glucose lowering. No reduction in albuminuria, glomerulosclerotic index or cortical collagen deposition was observed.Linagliptin inhibits activation of TGFß1 through a M6P dependent mechanism. However this in isolation is not sufficient to reverse the multifactorial nature of diabetic nephropathy.

  6. Aqueous-phase photooxidation of levoglucosan - a mechanistic study using aerosol time-of-flight chemical ionization mass spectrometry (Aerosol ToF-CIMS)

    Science.gov (United States)

    Zhao, R.; Mungall, E. L.; Lee, A. K. Y.; Aljawhary, D.; Abbatt, J. P. D.

    2014-09-01

    Levoglucosan (LG) is a widely employed tracer for biomass burning (BB). Recent studies have shown that LG can react rapidly with hydroxyl (OH) radicals in the aqueous phase despite many mass balance receptor models assuming it to be inert during atmospheric transport. In the current study, aqueous-phase photooxidation of LG by OH radicals was performed in the laboratory. The reaction kinetics and products were monitored by aerosol time-of-flight chemical ionization mass spectrometry (Aerosol ToF-CIMS). Approximately 50 reaction products were detected by the Aerosol ToF-CIMS during the photooxidation experiments, representing one of the most detailed product studies yet performed. By following the evolution of mass defects of product peaks, unique trends of adding oxygen (+O) and removing hydrogen (-2H) were observed among the products detected, providing useful information for determining potential reaction mechanisms and sequences. Additionally, bond-scission reactions take place, leading to reaction intermediates with lower carbon numbers. We introduce a data analysis framework where the average oxidation state (OSc) is plotted against a novel molecular property: double-bond-equivalence-to-carbon ratio (DBE/#C). The trajectory of LG photooxidation on this plot suggests formation of polycarbonyl intermediates and their subsequent conversion to carboxylic acids as a general reaction trend. We also determined the rate constant of LG with OH radicals at room temperature to be 1.08 ± 0.16 × 109 M-1 s-1. By coupling an aerosol mass spectrometer (AMS) to the system, we observed a rapid decay of the mass fraction of organic signals at mass-to-charge ratio 60 (f60), corresponding closely to the LG decay monitored by the Aerosol ToF-CIMS. The trajectory of LG photooxidation on a f44-f60 correlation plot matched closely to literature field measurement data. This implies that aqueous-phase photooxidation might be partially contributing to aging of BB particles in the

  7. Aqueous-phase photooxidation of levoglucosan - a mechanistic study using Aerosol Time of Flight Chemical Ionization Mass Spectrometry (Aerosol-ToF-CIMS)

    Science.gov (United States)

    Zhao, R.; Mungall, E. L.; Lee, A. K. Y.; Aljawhary, D.; Abbatt, J. P. D.

    2014-04-01

    Levoglucosan (LG) is a widely employed tracer for biomass burning (BB). Recent studies have shown that LG can react rapidly with hydroxyl (OH) radicals in the aqueous phase, despite many mass balance receptor models assuming it to be inert during atmospheric transport. In the current study, aqueous-phase photooxidation of LG by OH radicals was performed in the laboratory. The reaction kinetics and products were monitored by Aerosol Time of Flight Chemical Ionization Mass Spectrometry (Aerosol-ToF-CIMS). Approximately 50 reaction products were detected by the Aerosol-ToF-CIMS during the photooxidation experiments, representing one of the most detailed product studies yet performed. By following the evolution of mass defects of product peaks, unique trends of adding oxygen (+O) and removing hydrogen (-2H) were observed among the products detected, providing useful information to determine potential reaction mechanisms and sequences. As well, bond scission reactions take place, leading to reaction intermediates with lower carbon numbers. We introduce a data analysis framework where the average oxidation state (OSc) is plotted against a novel molecular property: double bond equivalence to carbon ratio (DBE / #C). The trajectory of LG photooxidation on this plot suggests formation of poly-carbonyl intermediates and their subsequent conversion to carboxylic acids as a general reaction trend. We also determined the rate constant of LG with OH radicals at room temperature to be 1.08 ± 0.16 × 109 M-1 s-1. By coupling an Aerosol Mass Spectrometer (AMS) to the system, we observed a rapid decay of the mass fraction of organic signals at mass-to-charge ratio 60 (f60), corresponding closely to the LG decay monitored by the Aerosol-ToF-CIMS. The trajectory of LG photooxidation on a f44-f60 correlation plot matched closely to literature field measurement data. This implies that aqueous-phase photooxidation might be partially contributing to aging of BB particles in the ambient

  8. Novel metastasis-related gene CIM functions in the regulation of multiple cellular stress-response pathways.

    Science.gov (United States)

    Yanagisawa, Kiyoshi; Konishi, Hiroyuki; Arima, Chinatsu; Tomida, Shuta; Takeuchi, Toshiyuki; Shimada, Yukako; Yatabe, Yasushi; Mitsudomi, Tetsuya; Osada, Hirotaka; Takahashi, Takashi

    2010-12-01

    Various stresses of the tumor microenvironment produced by insufficient nutrients, pH, and oxygen can contribute to the generation of altered metabolic and proliferative states that promote the survival of metastatic cells. Among many cellular stress-response pathways activated under such conditions are the hypoxia-inducible factor (HIF) pathway and the unfolded protein response (UPR), which is elicited as a response to endoplasmic reticulum (ER) stress. In this study, we report the identification of a novel cancer invasion and metastasis-related gene (hereafter referred to as CIM, also called ERLEC1), which influences both of these stress-response pathways to promote metastasis. CIM was identified by comparing the gene expression profile of a highly metastatic human lung cancer cell line with its weakly metastatic parental clone. We showed that CIM is critical for metastatic properties in this system. Proteomic approaches combined with bioinformatic analyses revealed that CIM has multifaceted roles in controlling the response to hypoxia and ER stress. Specifically, CIM sequestered OS-9 from the HIF-1α complex and PHD2, permitting HIF-1α accumulation by preventing its degradation. Ectopic expression of CIM in lung cancer cells increased their tolerance to hypoxia. CIM also modulated UPR through interaction with the key ER stress protein BiP, influencing cell proliferation under ER stress conditions. Our findings shed light on how tolerance to multiple cellular stresses at a metastatic site can be evoked by an integrated mechanism involving CIM, which can function to coordinate those responses in a manner that promotes metastatic cell survival.

  9. Rice Seed Priming with Picomolar Rutin Enhances Rhizospheric Bacillus subtilis CIM Colonization and Plant Growth.

    Directory of Open Access Journals (Sweden)

    Akanksha Singh

    Full Text Available The effect of rutin, a bioflavonoid on the growth and biofilm formation of Bacillus subtilis strain CIM was investigated. In addition to swimming, swarming, and twitching potentials of B. subtilis CIM (BS, one picomolar (1 pM of rutin was also observed to boost the biofilm forming ability of the bacterium. Bio-priming of rice seeds with BS and rutin not only augmented root and shoot lengths but also the photosynthetic pigments like chlorophyll and carotenoid. Similarly, high accumulation of phenolic and flavonoid contents was observed in the leaves. Fluorescent microscopic images revealed that BS plus rutin enhanced callose deposition in the leaves. It was also established that the least formation of reactive oxygen species in BS plus rutin treated rice plants was due to higher free radicals scavenging activity and total antioxidant potential. The results highlight chemo attractant nature of BS towards rutin, which by enhancing biofilm formation and root colonization indirectly strengthened the plants' defensive state.

  10. Convective Interaction Media (CIM)--short layer monolithic chromatographic stationary phases.

    Science.gov (United States)

    Podgornik, Ales; Strancar, Ales

    2005-01-01

    Modern downstream processing requires fast and highly effective methods to obtain large quantities of highly pure substances. Commonly applied method for this purpose is chromatography. However, its main drawback is its throughput since purification, especially of large molecules, requires long process time. To overcome this problem several new stationary phases were introduced, among which short layer monoliths show superior properties for many applications. The purpose of this review is to give an overview about short methacrylate monolithic columns commercialised under the trademark Convective Interaction Media (CIM). Their unique properties are described from different perspectives, explaining reasons for their application on various areas. Approaches to prepare large volume methacrylate monolithic column are discussed and optimal solutions are given. Different examples of CIM monolithic column implementation are summarised in the last part of the article to give the reader an idea about their advantages.

  11. Rice Seed Priming with Picomolar Rutin Enhances Rhizospheric Bacillus subtilis CIM Colonization and Plant Growth.

    Science.gov (United States)

    Singh, Akanksha; Gupta, Rupali; Pandey, Rakesh

    2016-01-01

    The effect of rutin, a bioflavonoid on the growth and biofilm formation of Bacillus subtilis strain CIM was investigated. In addition to swimming, swarming, and twitching potentials of B. subtilis CIM (BS), one picomolar (1 pM) of rutin was also observed to boost the biofilm forming ability of the bacterium. Bio-priming of rice seeds with BS and rutin not only augmented root and shoot lengths but also the photosynthetic pigments like chlorophyll and carotenoid. Similarly, high accumulation of phenolic and flavonoid contents was observed in the leaves. Fluorescent microscopic images revealed that BS plus rutin enhanced callose deposition in the leaves. It was also established that the least formation of reactive oxygen species in BS plus rutin treated rice plants was due to higher free radicals scavenging activity and total antioxidant potential. The results highlight chemo attractant nature of BS towards rutin, which by enhancing biofilm formation and root colonization indirectly strengthened the plants' defensive state.

  12. Utilizing a Photo-Analysis Software for Content Identifying Method (CIM

    Directory of Open Access Journals (Sweden)

    Nejad Nasim Sahraei

    2015-01-01

    Full Text Available Content Identifying Methodology or (CIM was developed to measure public preferences in order to reveal the common characteristics of landscapes and aspects of underlying perceptions including the individual's reactions to content and spatial configuration, therefore, it can assist with the identification of factors that influenced preference. Regarding the analysis of landscape photographs through CIM, there are several studies utilizing image analysis software, such as Adobe Photoshop, in order to identify the physical contents in the scenes. This study attempts to evaluate public’s ‘preferences for aesthetic qualities of pedestrian bridges in urban areas through a photo-questionnaire survey, in which respondents evaluated images of pedestrian bridges in urban areas. Two groups of images were evaluated as the most and least preferred scenes that concern the highest and lowest mean scores respectively. These two groups were analyzed by CIM and also evaluated based on the respondent’s description of each group to reveal the pattern of preferences and the factors that may affect them. Digimizer Software was employed to triangulate the two approaches and to determine the role of these factors on people’s preferences. This study attempts to introduce the useful software for image analysis which can measure the physical contents and also their spatial organization in the scenes. According to the findings, it is revealed that Digimizer could be a useful tool in CIM approaches through preference studies that utilizes photographs in place of the actual landscape in order to determine the most important factors in public preferences for pedestrian bridges in urban areas.

  13. Separation of pegylated recombinant proteins and isoforms on CIM ion exchangers.

    Science.gov (United States)

    Gašperšič, Jernej; Podgornik, Aleš; Kramberger, Petra; Jarc, Marko; Jančar, Janez; Žorž, Mirjan; Krajnc, Nika Lendero

    2016-10-15

    Protein pegylation is a process of covalent attachment of a polyethylene glycol (PEG) group to the protein tertiary structure that can "mask" the agent from the immune system and also increases the hydrodynamic size of the agent. Usually the pegylation prolongs the protein stability in the organism due to reduced renal clearance and provides superior water solubility to hydrophobic molecules. The mono-pegylated form of protein is usually prefered for medical applications. Different conditions with different PEG reagents have to be tested to find optimal pegylation procedure with specific protein. The goal of this study was to prepare screening method for separation of random mono-pegylated protein. Cytochrome C and beta lactoglobulin were pegylated with four reagents and a complete screening of several chromatographic monoliths in ion exchange mode with different buffers was performed to optimaly separate each mono-pegylated protein. The screening method was developed that produces optimal separation of target pegylated protein on CIM monoliths. Because of short chromatographic run time, CIM monoliths are perfect candidates to test alot of parameters. The results obtained show that each protein has its own unique separation parameters (pH, ionexchange ligand, buffer type). Two biopharmaceuticals were isolated using protocol: super human leptin antagonist (SHLA) was purified from inclusion bodies and mono-pegylated super mouse leptin antagonist (SMLA) from pegylated mixture. During study it was observed that the convective interaction media (CIM) monoliths additionally discriminate between protein isoforms pegylated on different sites in 3D structure of the protein.

  14. Treatment for Chiari 1 malformation (CIM): analysis of a pediatric surgical series.

    Science.gov (United States)

    Valentini, Laura; Visintini, Sergio; Saletti, Veronica; Chiapparini, Luisa; Estienne, Margherita; Solero, Carlo Lazzaro

    2011-12-01

    Children may present a peculiar picture of CIM, as syncopes and acute paraparesis. In a series of 99 children operated for CIM at FINCB there were no major surgical morbidity nor mortality. The preoperative symptoms improved more in this pediatric series than in the adult cases treated at the same institution in the same period; a reason could be the shorter duration of symptoms and another the children plasticity. An untreated nonsyndromic craniosynostosis was present in 10 cases. In our hands, the results of the limited extradural decompression were poor. In some CIM associated with psychiatric symptoms an unexpected improvement was observed after tonsilar resection. The associated Syringomyelia reduced in more than 80% of children and disappeared in a significant number. The rare associated tethered cord (5%) needed a double treatment, detethering by itself being insufficient to treat also tonsillar descent. The clinical symptoms are often more serious in children than in the adults, but the results of surgery, especially on the syrinx, are better.

  15. Design and Development of a CIM Architecture for Food Manufacturing

    Science.gov (United States)

    1994-07-01

    to support the IDEFIX Model Pro Software of D. Appleton, Inc., which requires a VGA monitor. This task, completed in the quarter ending April, 1990...architecture that covered both civilian and military product manufacture. This architecture, defined in IDEFIX modeling language, became the basis for...its extension, IDEFIX , is a methodology for modeling data entities and their relation- i ships. An entity is represented by a box labeled by a noun

  16. Distinct muscle apoptotic pathways are activated in muscles with different fiber types a rat model of critical illness myopathy

    OpenAIRE

    Barnes, Benjamin T.; Confides, Amy L.; Rich, Mark M.; Dupont-Versteegden, Esther E.

    2015-01-01

    Critical illness myopathy (CIM) is associated with severe muscle atrophy and fatigue in affected patients. Apoptotic signaling is involved in atrophy and is elevated in muscles from patients with CIM. In this study we investigated underlying mechanisms of apoptosis-related pathways in muscles with different fiber type composition in a rat model of CIM using denervation and glucocorticoid administration (denervation and steroid-induced myopathy, DSIM). Soleus and tibialis anterior (TA) muscles...

  17. CIMS: A Context-Based Intelligent Multimedia System for Ubiquitous Cloud Computing

    Directory of Open Access Journals (Sweden)

    Abhilash Sreeramaneni

    2015-06-01

    Full Text Available Mobile users spend a tremendous amount of time surfing multimedia contents over the Internet to pursue their interests. A resource-constrained smart device demands more intensive computing tasks and lessens the battery life. To address the resource limitations (i.e., memory, lower maintenance cost, easier access, computing tasks in mobile devices, mobile cloud computing is needed. Several approaches have been proposed to confront the challenges of mobile cloud computing, but difficulties still remain. However, in the coming years, context collecting, processing, and interchanging the results on a heavy network will cause vast computations and reduce the battery life in mobiles. In this paper, we propose a “context-based intelligent multimedia system” (CIMS for ubiquitous cloud computing. The main goal of this research is to lessen the computing percentage, storage complexities, and battery life for mobile users by using pervasive cloud computing. Moreover, to reduce the computing and storage concerns in mobiles, the cloud server collects several groups of user profiles with similarities by executing K-means clustering on users’ data (context and multimedia contents. The distribution process conveys real-time notifications to smartphone users, according to what is stated in his/her profile. We considered a mobile cloud offloading system, which decides the offloading actions to/from cloud servers. Context-aware decision-making (CAD customizes the mobile device performance with different specifications such as short response time and lesser energy consumption. The analysis says that our CIMS takes advantage of cost-effective features to produce high-quality information for mobile (or smart device users in real time. Moreover, our CIMS lessens the computation and storage complexities for mobile users, as well as cloud servers. Simulation analysis suggests that our approach is more efficient than existing domains.

  18. Application of Lithium Attachment Mass Spectrometry for Knudsen Evaporation and Chemical Ionisation Mass Spectrometry (KEMS, CIMS)

    Science.gov (United States)

    Bannan, Thomas; Booth, A. Murray; Alfarra, Rami; Bacak, Asan; Pericval, Carl

    2016-04-01

    Lithium ion attachment mass spectrometry provides a non-specific, non-fragmenting and sensitive method for detection of volatile species in the gas phase. The design, manufacture, and results from lithium ion attachment ionisation sources for two mass spectrometry systems are presented. Trace gas analysis is investigated using a modified Chemical Ionization Mass Spectrometer (CIMS) and vapour pressure (VP) measurements using a modified Knudsen Effusion Mass Spectrometer (KEMS) are presented. The Li+ modified CIMS provided limits of detection of 4 ppt for acetone, 0.2 ppt for formic acid, 15 ppt for nitric acid and 120 ppt from ammonia. Despite improvements, the problem of burnout remained persistent. The Li+ CIMS would unlikely be suitable for field or aircraft work, but could be appropriate for certain lab applications. The KEMS currently utilizes an electron impact (EI) ionisation source which provides a highly sensitive source, with the drawback of fragmentation of ionized molecules (Booth et al., 2009). Using Li+ KEMS the VP of samples can be measured without fragmentation and can therefore be used to identify VPs of individual components in mixtures. The validity of using Li+ for determining the VP of mixtures was tested by making single component VP measurements, which showed good agreement with EI measurements of Poly ethylene glycol (PEG) 3 and PEG 4, both when individually measured and when mixed. The Li+ KEMS was then used to investigate a system of atmospheric relevance, α-pinene secondary organic aerosol, generated in a reaction chamber (Alfarra et al., 2012). The VPs of the individual components from this generated sample are within the range we expect for compounds capable of partitioning between the particle and gas phase of an aerosol (0.1-10-5 Pa). Li+ source has a calculated sensitivity approximately 75 times less than that of EI, but the lack of fragmentation using the Li+ source is a significant advantage.

  19. Chemical ionization mass spectrometry (CIMS may not measure all gas-phase sulfuric acid if base molecules are present

    Directory of Open Access Journals (Sweden)

    T. Kurtén

    2010-12-01

    Full Text Available The state-of-the art method for measuring atmospheric gas-phase sulfuric acid is chemical ionization mass spectrometry (CIMS based on nitrate reagent ions. Using computed proton affinities and reaction thermodynamics for the relevant charging reactions, we show that in the presence of strong bases such as amines, which tend to cluster with the sulfuric acid molecules, a significant fraction of the total gas-phase sulfuric acid may not be measured by a CIMS instrument. If this is the case, this effect has to be taken into account in the interpretation of atmospheric sulfuric acid measurement data, as well as in intercomparison of different CIMS instruments, which likely have different susceptibilities to amine-sulfuric acid clustering.

  20. Non-invasive diagnosis of H pylori infection: Evaluation of serological tests with and without current infection marker CIM

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    AIM: To evaluate the performance of commercially available immunochromatographic (ICT) and immunoblot tests covering the current infection marker CIM and conventional ELISA for the diagnosis of Hpylori infection in adult dyspeptic patients. METHODS: Consecutive non-treated dyspeptic patients undergoing diagnostic endoscopy were tested for H pylori infection by culture, rapid urease test, and histology of gastric biopsy specimens. Serum from 61 H pylori infected and 21 non-infected patients were tested for anti-H pylori IgG antibodies by commercial ELISA (Accu Bind TM ELISA, Monobind, USA), ICT(Assure(R) H pylori Rapid Test, Genelabs Diagnostics, Singapore),and immunoblot (Helico Blot 2.1,Genelabs Diagnostics, Singapore) assays. ICT and immunoblot kits cover CIN among other parameters and their performance with and without CIM was evaluated separately. RESULTS: Sensitivity, specificity, positive predictive value (PPV),negative predictive value (NPV),and accuracy of ELISA were 96.7%,42.8%,83.1%,81.8%,and 82.9%,of ICT were 90.1%,80.9%,93.2%,73.9%,and 87.8%,of ICE with CIM were 88.5%,90.4%,96.4%,73.0%,and 89.0%,of immunoblot were 98.3%,80.9%,93.7%,94.4%,and 93.9%,and of immunoblot with CIM were 98.3%,90.4%,96.7%,95.0%,and 96.3%,respectively.CONCLUSION:Immunoblot with CIM had the best performance. ICE with CIM was found to be more specific and accurate than the conventional ELISA and may be useful for non-invasive diagnosis of H pylori infection.

  1. Comparing Transformation Possibilities of Topological Functioning Model and BPMN in the Context of Model Driven Architecture

    Directory of Open Access Journals (Sweden)

    Solomencevs Artūrs

    2016-05-01

    Full Text Available The approach called “Topological Functioning Model for Software Engineering” (TFM4SE applies the Topological Functioning Model (TFM for modelling the business system in the context of Model Driven Architecture. TFM is a mathematically formal computation independent model (CIM. TFM4SE is compared to an approach that uses BPMN as a CIM. The comparison focuses on CIM modelling and on transformation to UML Sequence diagram on the platform independent (PIM level. The results show the advantages and drawbacks the formalism of TFM brings into the development.

  2. Integrated Enterprise Modeling Method Based on Workflow Model and Multiviews%Integrated Enterprise Modeling Method Based on Workflow Model and Multiviews

    Institute of Scientific and Technical Information of China (English)

    林慧苹; 范玉顺; 吴澄

    2001-01-01

    Many enterprise modeling methods are proposed to model thebusiness process of enterprises and to implement CIM systems. But difficulties are still encountered when these methods are applied to the CIM system design and implementation. This paper proposes a new integrated enterprise modeling methodology based on the workflow model. The system architecture and the integrated modeling environment are described with a new simulation strategy. The modeling process and the relationship between the workflow model and the views are discussed.

  3. Comprehensive Instructional Management System (CIMS) Mathematics Project 1985-1986 End of Year Report. OEA Evaluation Report.

    Science.gov (United States)

    New York City Board of Education, Brooklyn. Office of Educational Assessment.

    This report describes the Comprehensive Instructional Management System (CIMS), which includes a teacher-developed mathematics curriculum for kindergarten through grade seven, corresponding criterion-referenced tests, and a computerized test scoring and reporting management system. The evaluation focused on the five pilot districts in New York…

  4. Comprehensive Instructional Managmenent Systems-Communication Arts (CIMS-CA), 1988-89. Evaluation Section Report. OREA REport.

    Science.gov (United States)

    Guerrero, Frank; And Others

    This report presents the results of the evaluation of the 1988-89 Comprehensive Instructional Management Systems-Communication Arts (CIMS-CA) program, which focused on developing a holistic communication arts curriculum and staff development program reflecting the most recent research for students in kindergarten through eighth grade;…

  5. Alignment of CIM and CAM Content Standards and Benchmarks with the PASS Proficiency Standards, Content Area: English.

    Science.gov (United States)

    Oregon State Dept. of Education, Salem.

    This paper presents the alignment of Oregon's content standards with the Certificates of Initial Mastery (CIM), Certificates of Advanced Mastery (CAM), and the Proficiency-based Admissions Standards System (PASS). After some background, a timeline, and definitions of 4 terms used in the paper, it presents charts that align common curriculum goals…

  6. Research on CIMS Information Classification and Coding Based on OO%基于OO的CIMS信息分类编码研究

    Institute of Scientific and Technical Information of China (English)

    皮德常; 张凤林; 丁宗红; 王宁生

    2000-01-01

    A classification and coding system FCC links-oriented in CIMS is introduced.This method is based on the analysis of a lot of national and international classification and coding systems, the requirement of information integrated in CIMS and the object-oriented method. Firstly, we analyze the necessity of adopting OO (Object-oriented) method to construct this model and propose, a scheme composed of complex object O and operation M which is applied to the object O which is a 3-tuples describing object identifier, object feature and graph feature. Object identifier is a 2-tuples. The item of graph feature is a 4-tuples, which describes identifier ,sign, signature and files of the graph. Secondly, we propose the FCC structure description of classification and coding based on OO. In the structure, we use the links of field domain and super class / subclass, then we flat the complex object model into a relation, and the flatted relation structure can be described asobject identifier, registration and signature description. Thirdly, the system bottom adopts relation to implement the OO structure, which is compatible with the other coding system. The above-mentioned method provides a guarantee for data exchanging and sharing in CIMS. Finally, we believe that it is an indefinite and flexible levels and orients the signature of object, it effectively solves the problem to classification and information in CIMS.%通过分析国内外现有各分类编码系统以及CIMS对信息集成的要求,结合面向对象(Object-oriented,OO)方法提出了一种面向CIMS各环节的分类编码结构模型FCC。该模型由复杂对象O和施加于O上的操作M构成,其中O可描述为一个三元组,用于类别标识,事物特征描述和图形特征描述。类别标识项是一个可用二元组描述的复杂对象;图形特征项是一个四元组,描述了图形标识,图形符号,图形特征数据和图形文件;为描述FCC结构引人了属性域连

  7. 影响SDAAC-CIMS工程实施的几个关键问题的研究%Research on Critical Issues Affecting SDAAC-CIMS Implementation

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Computer integrated manufacturing system ( CIMS ) has received much attention in many industrialized countries. Shang hai Delphi Automobile Air Condition System Co., Ltd. (SDAAC), which is one of the large-scale key joint-venture enterprises engaged in developing, designing and manufacturing automobile air condition system in China, was selected for implementing 863/CIMS in 1998. The experience and lessons of the developing and implementing CIMS in the last 10 years have told us that SDAAC-CIMS is not meraly a technology exercise but an “organization revolution”. There are often much difficulties in implementing SDAAC-CIMS simply on the traditional business system. So the contents of the SDAAC-CIMS implementation is not only technical integration but also integration of people/organization, business processes and technologies. Therefore, several critical issues that must be carefully considered to ensure successful implementation of SDAAC-CIMS include commitment of the top management, reengineering of the existing processes in order to construct dynamic stable structures for aligning the SDAAC to the chaotic environment, and integration platform of information for coping with continuously changing circumstance.

  8. INCIDENCE, ETIOLOGY AND PATTERN OF MANDIBULAR FRACTURE IN CIMS, BILASPUR, CG, INDIA

    Directory of Open Access Journals (Sweden)

    Singh

    2015-10-01

    Full Text Available The aim of this study was to determine the incidence, etiology of mandibular fractures among different age and sex group to determine the frequency of anatomical distribution of fracture site. The study was conducted in the Department of ENT in associatio n with Department of Dentistry, CIMS, and Bilaspur. We included total 100 patients particularly with mandibular fracture and associated maxillofacial injuries. These patients were treated at Chhattisgarh Institute of Medical Sciences, Bilaspur from May 201 2 to April 2015. Among these 100 patients the most common cause of mandib le fracture is Road Traffic Acc idents with parasymphysis fracture as most common site. Incident of Mandibular fracture is mainly observed in male patients with 20 – 30 years of age group

  9. On Ground Surface Extraction Using Full-Waveform Airborne Laser Scanner for Cim

    Science.gov (United States)

    Nakano, K.; Chikatsu, H.

    2015-05-01

    Satellite positioning systems such as GPS and GLONASS have created significant changes not only in terms of spatial information but also in the construction industry. It is possible to execute a suitable construction plan by using a computerized intelligent construction. Therefore, an accurate estimate of the amount of earthwork is important for operating heavy equipment, and measurement of ground surface with high accuracy is required. A full-waveform airborne laser scanner is expected to be capable of improving the accuracy of ground surface extraction for forested areas, in contrast to discrete airborne laser scanners, as technological innovation. For forested areas, fundamental studies for construction information management (CIM) were conducted to extract ground surface using full-waveform airborne laser scanners based on waveform information.

  10. Dive Activities from Cruise Information Management System (CIMS) for Estuary to the Abyss 2004: Exploring Along the Latitude 31-30 Transect - Office of Ocean Exploration

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Information about dive activities were recorded into the Cruise Information Management System (CIMS) by the NOAA Office of Ocean Exploration's data manager during...

  11. Dive Activities from Cruise Information Management System (CIMS) for Life on the Edge 2003: Exploring Deep Ocean Habitats - Office of Ocean Exploration

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Information about dive activities were recorded into the Cruise Information Management System (CIMS) by the NOAA Office of Ocean Exploration's data manager during...

  12. Secondary organic material formed by methylglyoxal in aqueous aerosol mimics – Part 2: Product identification using Aerosol-CIMS

    Directory of Open Access Journals (Sweden)

    V. F. McNeill

    2009-07-01

    Full Text Available We used chemical ionization mass spectrometry with a volatilization flow tube inlet (Aerosol-CIMS to characterize secondary organic material formed by methylglyoxal with ammonium sulfate in aqueous aerosol mimics. Bulk reaction mixtures were diluted and atomized to form submicron aerosol particles. Organics were detected using Aerosol-CIMS in positive and negative ion mode using I− and H3O+·(H2On as reagent ions. The results are consistent with aldol condensation products, carbon-nitrogen species, sulfur-containing compounds, and oligomeric species up to 759 amu. These results support previous observations by us and others that ammonium sulfate plays a critical role in the SOA formation chemistry of dicarbonyl compounds.

  13. Cl2 Measurements in Polluted Coastal Air Using a Br- Addition CIMS Technique

    Science.gov (United States)

    Lawler, M. J.; Saltzman, E. S.

    2008-12-01

    Molecular chlorine (Cl2) was measured in ambient air using chemical ionization mass spectrometry (CIMS) with Br- as a reagent ion. Ionization was carried out by adding CHBr3 to ambient air and flowing the gas mixture through a 63Ni ion source maintained at 300 Torr. The resulting Cl2Br- adduct was collisionally dissociated in a triple quadrupole mass spectrometer and detected as Cl-. Ambient Cl2 measurements were made at Irvine, CA, from August 1-8, 2008. Air was drawn to the instrument from outside via a ~4m long laminar flow inlet. Inlet and instrument blanks were assessed by passing ambient air through carbonate-coated glass wool, and the instrument was calibrated with a Cl2 permeation tube. During this study, the mean detection limit for Cl2 was estimated at approximately 2 ppt. Cl2 showed a diel cycle on the days it was detectable, with nighttime mixing ratios up to about 15 ppt and daytime values of a few ppt or less. A rapid decrease in Cl2 in surface air was observed overnight in association with stagnation of the nocturnal surface layer.

  14. Rhizospheric Microflora Escalating Aroma Constituents and Yield Attributes in Ocimum tenuiflorum (L. cv. CIM-Ayu

    Directory of Open Access Journals (Sweden)

    Shilpi Khare Saikia

    2014-01-01

    Full Text Available The exploration of rhizospheric microbial flora for crop yield enhancement is well established. Rhizospheric microbes influence the plant physiology by imparting several beneficial effects, namely, Nitrogen fixation, increased nutrient uptake, and secondary metabolites production on their host plants. The present study investigates the response of Bacillus megaterium ATCC No. 13525, Pseudomonas fluorescens ATCC No. 14581, and Trichoderma viride MTCC No. 167 in alone and combined treatments for their effect on growth and yield parameters in a commercially important Ocimum tenuiflorum L. cv. CIM-Ayu. The plant is therapeutically important for its essential oil constituents, namely, eugenol, β-caryophyllene, and various monoterpenes. The combination treatments, T7 (B. megaterium + P. fluorescens and T8 (B. megaterium + P. fluorescens + T. viride, showed maximum enhancement (27.27% of percentage essential oil as compared to untreated control. Nutrient uptake especially N2 content was significantly increased (43% with the treatment T8 (B. megaterium + P. fluorescens + T. viride. Amongst major essential oil constituents, eugenol content was maximally increased by 58.5% as compared to 42.9% (control indicating a cumulative role of microbial inoculants for crop yield boost-up.

  15. Control in the middle (CIM) for three-period crossover studies.

    Science.gov (United States)

    Shuster, Jonathan; Anton, Stephen D; Theriaque, Douglas; Yoon, Saunjoo

    2011-09-01

    Three-period crossover studies can be efficient and convenient methods of conducting Phase II clinical trials. Non-randomly placing control in the middle (CIM) has not been practiced but may be extremely useful in studies testing herbal products for which placebos are not available, or for distinguishing between behavioral and biological effects. Furthermore, this design can serve as a valuable addition to classical studies of either (a) two competing treatments or (b) treatment versus placebo versus an open label "nothing" as the control. Therefore, we propose rigorous designs that will help practitioners efficiently answer research questions where (1) two active treatments need to be compared against each other with treatment vs. placebo comparisons being of secondary importance; (2) a single active treatment needs to be tested where no placebo is available; or (3) the placebo effect is of interest in a treatment vs. placebo trial. For studies where no placebo is available, deception will be required, with participants told that in one randomly selected period (#1 or #3) they will receive the active treatment, and that they will receive a new experimental inert placebo in the other period. Assuming this design is approved by an ethics committee, it can be very useful in biomedical research.

  16. Variation in the volatile constituents of Artemisia annua var. CIM-Arogya during plant ontogeny.

    Science.gov (United States)

    Padalia, Rajendra C; Verma, Ram S; Chauhan, Amit; Chanotiya, Chandan S; Yadav, Anju

    2011-02-01

    The essential oils yield and composition of the aerial parts of A. annua var. CIM-Arogya grown in Uttarakhand, India were analyzed and compared by capillary GC and GC-MS at different stages of development. The analysis led to the identification of 81 constituents forming 91.0%-97.1% of the essential oils compositions. The essential oil content of the aerial parts was found to vary from 0.3% to 0.7% at different stages of growth. A. annua crop harvested at full flowering and seed setting stage gave higher yield of essential oil (0.6%, 0.7%) than that harvested at pre flowering (0.5%), late vegetative (0.4%, 0.5%), mid vegetative (0.4%, 0.4%) and early vegetative stages (0.3%, 0.3%). The essential oils at different stages of growth showed monoterpenoids (38.5%-72.0%) and sesquiterpenoids (22.2%-48.2%) as major grouped constituents. The major constituents identified were camphor (22.8%-42.6%), 1,8-cineole (3.7%-8.4%), linalool (<0.1%-11.9%), beta-caryophyllene (2.0%-9.2%), (E)-beta-farnesene (1.3%-8.5%), germacrene D (0.5%-7.3%) and 1-epi-cubenol (0.7%-5.2%) in essential oil samples collected at different crop stages.

  17. Dextranase immobilization on epoxy CIM(®) disk for the production of isomaltooligosaccharides from dextran.

    Science.gov (United States)

    Bertrand, Emmanuel; Pierre, Guillaume; Delattre, Cédric; Gardarin, Christine; Bridiau, Nicolas; Maugard, Thierry; Štrancar, Aleš; Michaud, Philippe

    2014-10-13

    Endodextranase D8144 from Penicillium sp. (EC 3.2.1.2.) was immobilized on an epoxy-activated monolithic Convective Interaction Media (CIM(®)) disk in order to produce isomaltooligosaccharides (IMOS) from Dextran T40 in a continuous IMmobilized Enzymes Reactor (IMER). Enzymatic parameters and structure of IMOS were studied for free and immobilized enzymes. The immobilization efficiency of endodextranase D8144 was about 15.9% (w/w) and the real specific activity was close to 6.5 U mg enz(-1). The Km values (4.8 ± 0.2 g L(-1)) for free and immobilized enzymes were the same, showing the absence of diffusional limitation. Moreover, specific patterns of DPs (Degrees of Polymerization) distributions were observed during the enzymatic hydrolysis by HPAEC-PAD (High Pressure Anion Exchange Chromatography-Pulsed Amperometric Detection). Thus, sought-after sizes of IMOS (DPs 8-10) were generated all over the hydrolysis. Finally, the results showed the high stability of this IMER since a relative enzymatic activity about 78% was measured after 5400 volumes column.

  18. CASE ANALYSIS OF INNOVATION IN THE PACKAGING INDUSTRY USING THE CYCLIC INNOVATION MODEL

    OpenAIRE

    Ford, Nicholas; Trott, Paul; Simms, Chris; Hartmann, Dap

    2014-01-01

    This paper builds upon Berkhout et al.’s (2010) cyclic innovation model (CIM). This model was shown to provide an effective framework for understanding and managing the innovation process and to address many of the shortcomings of previous models. Building on that article we have applied CIM to an in-depth case study featuring a formable paperboard technology within the packaging industry. Using data gathered from 28 interviews conducted over a three year period, CIM, for the first time, is a...

  19. A STUDY OF PATTERN, SURGICAL MANAGE MENT AND OUTCOME OF BEAR MAULING AT CIMS BILASPUR

    Directory of Open Access Journals (Sweden)

    Santosh

    2015-07-01

    Full Text Available We studied the various injury patterns in bear mauling and outcome of management in CIMS from 2010 to 2014. A total of 20 cases evaluated which were predominantly male (95%. It is obvious that involvement of head, neck face and upper limb was in maximum cases. The age wise study shows that there was equal involvement of people from young, middle aged and older ones. It was a retrospective analysis of the reported cases. Most victims suffered from multiple injuries. Percentage wise distribution of the injuries and involvement of different body parts amongst observed cases were head neck face 75%, thorax and abdomen 40%, upper limb 75%, buttocks and genitals 30% , lower limb 50%. We observed that in 75% of cases of mutilation over h ead neck and face, it was most common site of bear mauling. Probably, it is because usually the attacks by bear is mainly on standing posture with hind limbs. All the patients were treated by a team led by surgeons including dental cum oral surgeon, otorhinolaryngologist, ophthalmologist and orthopedician. Surgical repair was done under all aseptic precaution and analgesia. Because of severe anatomical distortion of face and multiple fractures of facial bones with unstable and hanging mandible, in number of cases urgent tracheostomy was performed to restore the airways and for induction of general anesthesia. This also prevents aspiration and regurgitation. The excell ent blood supply of the face makes infection a rare occurrence with good antibiotic coverage. However, the injury may cause sufficient disfigurement and require extensive reconstruction. We also observed eye globe rupture in some cases and enucleation was inevitable. We conclude that multidisciplinary approach and follow up reduced the rate of infection and morbidity and mortality.

  20. Atmospheric Amines and Ammonia Measured with a Chemical Ionization Mass Spectrometer (CIMS)

    Energy Technology Data Exchange (ETDEWEB)

    You, Y.; Kanawade, V. P.; de Gouw, J. A.; Guenther, Alex B.; Madronich, Sasha; Sierra-Hernandez, M. R.; Lawler, M.; Smith, James N.; Takahama, S.; Ruggeri, G.; Koss, A.; Olson, K.; Baumann, K.; Weber, R. J.; Nenes, A.; Guo, H.; Edgerton, Eric S.; Porcelli, L.; Brune, W. H.; Goldstein, Allen H.; Lee, S.-H

    2014-11-19

    We report ambient measurements of amines and ammonia with a fast response chemical ionization mass spectrometer (CIMS) in a Southeastern U.S. forest in Alabama and a moderately polluted Midwestern site during the summer. In the Alabama forest, mostly C3-amines (from pptv to tens of pptv) and ammonia (up to 2 ppbv) were detected on a daily basis. C3-amines and ammonia showed similar diurnal trends and temperature and wind direction dependences, and were not associated with transported CO and SO2 plumes. Consistent with temperature dependences, amine and ammonia in the gas and aerosol phases showed opposite diurnal trends, indicating gas-to-particle partitioning of amines and ammonia. Temperature dependences also imply reversible processes of amines and ammonia evaporation from soil surfaces in daytime and deposition of amines and ammonia to soil surfaces at nighttime. Various amines (C1-C6) at the pptv level were observed in the transported biomass burning plumes, showing that biomass burning can be a substantial source of amines in the Southeast U.S. At the moderately polluted Kent site, higher concentrations of amines (C1-C6, from pptv to tens of pptv) and ammonia (up to 6 ppbv) were detected. Diurnal variations of C1- to C3-amines and ammonia were correlated with the ambient temperature. C4- to C6-amines showed abrupt increases during the nighttime, suggesting that they were emitted from local sources. These abundant amines and ammonia may in part explain the frequent new particle formation events reported from Kent. Lower amine concentrations at the rural forested site highlight the importance of constraining anthropogenic sources of amines.

  1. Atmospheric amines and ammonia measured with a Chemical Ionization Mass Spectrometer (CIMS

    Directory of Open Access Journals (Sweden)

    Y. You

    2014-06-01

    Full Text Available We report ambient measurements of amines and ammonia with a~fast response chemical ionization mass spectrometer (CIMS in a southeastern US forest in Alabama and a~moderately polluted Midwestern site during the summer. In the Alabama forest, mostly C3-amines (from pptv to tens of pptv and ammonia (up to 2 ppbv were detected on a daily basis. C3-amines and ammonia showed similar diurnal trends and temperature and wind direction dependences, and were not associated with transported CO and SO2 plumes. Consistent with temperature dependences, amine and ammonia in the gas and aerosol phases showed opposite diurnal trends, indicating gas-to-particle partitioning of amines and ammonia. Temperature dependences also imply reversible processes of amines and ammonia evaporation from soil surfaces in daytime and deposition of amines and ammonia to soil surfaces at nighttime. Various amines (C1–C6 at the pptv level were observed in the transported biomass burning plumes, showing that biomass burning can be a substantial source of amines in the Southeast US. At the moderately polluted Kent site, higher concentrations of amines (C1–C6, from pptv to tens of pptv and ammonia (up to 6 ppbv were detected. Diurnal variations of C1- to C3-amines and ammonia were correlated with the ambient temperature. C4- to C6-amines showed abrupt increases during the nighttime, suggesting that they were emitted from local sources. These abundant amines and ammonia may in part explain the frequent new particle formation events reported from Kent. Lower amine concentrations at the rural forested site highlight the importance of constraining anthropogenic sources of amines.

  2. CIM和DAS多样性的定量分析%Diversity Quantitative Analysis on CIM and DAS

    Institute of Scientific and Technical Information of China (English)

    徐智; 雷晴; 陈冬雷

    2014-01-01

    基于NUREG/CR-7007量化多样性的方法,分析了AP1000标准设计中部件接口模块(CIM)和多样化驱动系统(DAS)的多样性属性,计算了归一化多样性量值.多样性灵敏度分析揭示了CIM和DAS归一化多样性量值裕量的不足,给出了应加强对系统实施监控及可行的改进建议.

  3. Design of a microprocessor-based Control, Interface and Monitoring (CIM unit for turbine engine controls research

    Science.gov (United States)

    Delaat, J. C.; Soeder, J. F.

    1983-01-01

    High speed minicomputers were used in the past to implement advanced digital control algorithms for turbine engines. These minicomputers are typically large and expensive. It is desirable for a number of reasons to use microprocessor-based systems for future controls research. They are relatively compact, inexpensive, and are representative of the hardware that would be used for actual engine-mounted controls. The Control, Interface, and Monitoring Unit (CIM) contains a microprocessor-based controls computer, necessary interface hardware and a system to monitor while it is running an engine. It is presently being used to evaluate an advanced turbofan engine control algorithm.

  4. The effect of H2SO4 - amine clustering on chemical ionization mass spectrometry (CIMS) measurements of gas-phase sulfuric acid

    DEFF Research Database (Denmark)

    Kurten, T.; Petaja, T.; Smith, J.;

    2011-01-01

    by the CIMS instrument, though the most reliable computational methods employed predict this fraction to be small; on the order of ten percent or less. Third, the amine molecules will evaporate practically immediately after charging, thus evading detection. These effects may need to be taken into account......The state-of-the art method for measuring atmospheric gas-phase sulfuric acid is chemical ionization mass spectrometry (CIMS) based on nitrate reagent ions. We have assessed the possible effect of the sulfuric acid molecules clustering with base molecules on CIMS measurements using computational...... chemistry. From the computational data, three conclusions can be drawn. First, a significant fraction of the gas-phase sulfuric acid molecules are very likely clustered with amines if the amine concentration is around or above a few ppt. Second, some fraction of these acid-amine clusters may not be charged...

  5. 计算机集成制造(CIM),工业4.0及通往语义之路%Computer Integrated Manufacturing (CIM), Industrie 4.0 and the Way to Semantics

    Institute of Scientific and Technical Information of China (English)

    因果·罗莱; 惠敦炎

    2016-01-01

    为把工业4.0付诸实施,一个有用的和切实可行的标准是一个不能放弃的元素.人们应当规划标准化的路径.但是,可以预期的是,总会遇到意外的障碍和创建崭新的态势.人们可以预测,最大的障碍可能会出现在哪些领域?本文试图就这些问题通过阐述工业4.0与起源于1980年的计算机集成制造(CIM)标准化历程的相似之处给出答案.文章指出,针对当前的标准化工作,我们应从CIM-时代中汲取哪些教训,哪些方面是可以传承下去的,必定要踏上的新大陆究竟在何方?

  6. The carbapenem inactivation method (CIM), a simple and low-cost alternative for the Carba NP test to assess phenotypic carbapenemase activity in gram-negative rods.

    Science.gov (United States)

    van der Zwaluw, Kim; de Haan, Angela; Pluister, Gerlinde N; Bootsma, Hester J; de Neeling, Albert J; Schouls, Leo M

    2015-01-01

    A new phenotypic test, called the Carbapenem Inactivation Method (CIM), was developed to detect carbapenemase activity in Gram-negative rods within eight hours. This method showed high concordance with results obtained by PCR to detect genes coding for the carbapenemases KPC, NDM, OXA-48, VIM, IMP and OXA-23. It allows reliable detection of carbapenemase activity encoded by various genes in species of Enterobacteriaceae (e.g., Klebsiella pneumoniae, Escherichia coli and Enterobacter cloacae), but also in non-fermenters Pseudomonas aeruginosa and Acinetobacter baumannii. The CIM was shown to be a cost-effective and highly robust phenotypic screening method that can reliably detect carbapenemase activity.

  7. The carbapenem inactivation method (CIM, a simple and low-cost alternative for the Carba NP test to assess phenotypic carbapenemase activity in gram-negative rods.

    Directory of Open Access Journals (Sweden)

    Kim van der Zwaluw

    Full Text Available A new phenotypic test, called the Carbapenem Inactivation Method (CIM, was developed to detect carbapenemase activity in Gram-negative rods within eight hours. This method showed high concordance with results obtained by PCR to detect genes coding for the carbapenemases KPC, NDM, OXA-48, VIM, IMP and OXA-23. It allows reliable detection of carbapenemase activity encoded by various genes in species of Enterobacteriaceae (e.g., Klebsiella pneumoniae, Escherichia coli and Enterobacter cloacae, but also in non-fermenters Pseudomonas aeruginosa and Acinetobacter baumannii. The CIM was shown to be a cost-effective and highly robust phenotypic screening method that can reliably detect carbapenemase activity.

  8. 网络数据库管理技术在CIMS工程中的应用%MANAGEMENT TECHNOLOGY OF WEB DATABASE FOR APPLICATIONS IN CIMS ENGINEERING

    Institute of Scientific and Technical Information of China (English)

    孟飙; 贺向新

    2001-01-01

    CIMS技术在制造业的应用是制造业和信息技术融合必然趋势.作为CIMS应用的支撑平台也随着Internet的迅猛发展不断完善提高,因而Web技术和企业Internet数据的集成一直是人们关注的热点.本文在研究参考了多种Web和CIMS技术之后,通过一定程度的验证,提出了适合中小企业应用的信息方案.%Accompanying by the development of IT since 20 century,all kinds of enterprise have had a great change on its management,production,and so on. It is an inevitable tendency that CIMS and IT technologies are fusing in the applications of CIMS technologies in manufacture. The supporting platform for CIMS applications are becoming flawless unceasingly following the rapidly developing of Internet,hence ,the integrated technology of Web and data from enterprises intranet is a hotspot for a long time. In this article,after researching and referencing manifold Web and CIMS technologies,with a validating in some degree,brings forward an information management project that is suitable to medium or small enterprises.

  9. The Carbapenem Inactivation Method (CIM), a Simple and Low-Cost Alternative for the Carba NP Test to Assess Phenotypic Carbapenemase Activity in Gram-Negative Rods

    NARCIS (Netherlands)

    Zwaluw, K. van der; Haan, A. de; Pluister, G.N.; Bootsma, H.J.; Neeling, A.J. de; Schouls, L.M.

    2015-01-01

    A new phenotypic test, called the Carbapenem Inactivation Method (CIM), was developed to detect carbapenemase activity in Gram-negative rods within eight hours. This method showed high concordance with results obtained by PCR to detect genes coding for the carbapenemases KPC, NDM, OXA-48, VIM, IMP a

  10. Determination of Zn-citrate in human milk by CIM monolithic chromatography with atomic and mass spectrometry detection.

    Science.gov (United States)

    Milačič, Radmila; Ajlec, Dejan; Zuliani, Tea; Žigon, Dušan; Ščančar, Janez

    2012-11-15

    In human milk zinc (Zn) is bound to proteins and low molecular mass (LMM) ligands. Numerous investigations demonstrated that Zn bioavailability in human milk is for infant much higher than in cow's milk. It was presumed that in the LMM human milk fraction highly bioavailable Zn-citrate prevails. However, literature data are controversial regarding the amount of Zn-citrate in human milk since analytical procedures reported were not quantitative. So, complex investigation was carried out to develop analytical method for quantitative determination of this biologically important molecule. Studies were performed within the pH range 5-7 by the use of synthetic solutions of Zn-citrate prepared in HEPES, MOPS and MES buffers. Zn-citrate was separated on weak anion-exchange convective interaction media (CIM) diethylaminoethyl (DEAE) monolithic chromatographic column using NH(4)NO(3) as an eluent. Separated Zn species were determined by flame atomic absorption spectrometry (FAAS) or inductively coupled plasma mass spectrometry (ICP-MS). Quantitative separation of Zn-citrate complexes ([Zn(Cit)](-) and [Zn(Cit)(2)](4-); column recoveries 94-102%) and good repeatability and reproducibility of results with relative standard deviation (RSD±3.0%) were obtained. In fractions under the chromatographic peaks Zn-binding ligand was identified by electrospray ionization tandem mass spectrometry (ESI-MS-MS). Limits of detection (LOD) for determination of Zn-citrate species by CIM DEAE-FAAS and CIM DEAE-ICP-MS were 0.01 μg Zn mL(-1) and 0.0005 μg Zn mL(-1), respectively. Both techniques were sensitive enough for quantification of Zn-citrate in human milk. Results demonstrated that about 23% of total Zn was present in the LMM milk fraction and that LMM-Zn corresponded to Zn-citrate. The developed speciation method represents a reliable analytical tool for investigation of the percentage and the amount of Zn-citrate in human milk.

  11. Assessment Of Mold-Design Dependent Textures In CIM-Components By Polarized Light Optical Texture Analysis (PLOTA)

    Science.gov (United States)

    Kern, Frank; Rauch, Johannes; Gadow, Rainer

    2007-04-01

    By thermoplastic ceramic injection moulding (CIM) ceramic components of high complexity can be produced in a large number of items at low dimensional tolerances. The cost advantage by the high degree of automation leads to an economical mass-production. The structure of injection-moulded components is determined by the form filling behaviour and viscosity of the feedstock, the machine parameters, the design of the mold and the gate design. With an adapted mold- and gate-design CIM-components without textures are possible. The "Polarized Light Optical Texture analysis" (PLOTA) makes it possible to inspect the components and detect and quantify the textures produced by a new mold. Based on the work of R. Fischer (2004) the PLOTA procedure was improved by including the possibility to measure the inclination angle and thus describe the orientation of the grains in three dimensions. Sampled thin sections of ceramic components are analysed under the polarization microscope and are brought in diagonal position. Pictures are taken with a digital camera. The pictures are converted in the L*a*b*- colour space and the crystals color values a* and b* in the picture are measured. The color values are compared with the values of a quartz wedge, which serves as universal standard. From the received values the inclination angle can be calculated relative to the microscope axis. It is possible to use the received data quantitatively e.g. for the FEM supported simulation of texture-conditioned divergences of mechanical values. Thus the injection molding parameters can be optimized to obtain improved mechanical properties.

  12. Affinity purification and enzymatic cleavage of inter-alpha inhibitor proteins using antibody and elastase immobilized on CIM monolithic disks.

    Science.gov (United States)

    Lim, Yow-Pin; Josic, Djuro; Callanan, Helen; Brown, Jeanne; Hixson, Douglas C

    2005-02-11

    Epoxy-activated monolithic CIM disks seem to be excellent supports for immobilization of protein ligands. The potential use of enzymes, immobilized on monolithic disks for rapid preparative cleavage proteins in solution was investigated. Digestion of complex plasma proteins was demonstrated by using inter-alpha inhibitors with elastase, immobilized on epoxy-activated CIM disks. Recently, a monoclonal antibody against human inter-alpha inhibitor proteins (MAb 69.31) was developed. MAb 69.31 blocks the inhibitory activity of inter-alpha inhibitor proteins to serine proteases. These results suggest that the epitope defined by this antibody is located within or proximal to the active site of the inhibitor molecule. This antibody, immobilized on monolithic disk, was used for very rapid isolation of inter-alpha proteins. The isolated complex protein was used for enzymatic digestion and isolation of cleavage products, especially from inter-alpha inhibitor light chain to elucidate precisely the target sequence for MAb 69.31 by N-terminal amino acid sequencing. Bovine pancreatic elastase immobilized on monolithic disk cleaves inter-alpha inhibitor protein complex into small fragments which are still reactive with MAb 69.31. One of these proteolytic fragments was isolated and partially sequenced. It could be shown that this sequence is located at the beginning of two proteinase inhibitor domains of the inter-alpha inhibitor light chain (bikunin). Elastase immobilized on monolithic disk offers a simple and rapid method for preparative isolation of protease cleavage fragments. The immobilized enzyme is stable and still active after repeated runs. A partial or complete digestion can be achieved by varying the flow rate.

  13. Semi-continuous measurements of gas/particle partitioning of organic acids in a ponderosa pine forest using a MOVI-HRToF-CIMS

    Directory of Open Access Journals (Sweden)

    R. L. N. Yatavelli

    2013-06-01

    Full Text Available Hundreds of gas and particle phase organic acids were measured in a rural ponderosa pine forest in Colorado, USA, during the Bio-hydro-atmosphere interactions of Energy, Aerosols, Carbon, H2O, Organics and Nitrogen – Rocky Mountain Biogenic Aerosol Study (BEACHON-RoMBAS. A recently developed Micro-Orifice Volatilization Impactor High-Resolution Time-of-Flight Chemical Ionization Mass Spectrometer (MOVI-HRToF-CIMS using acetate (CH3C(OO- as the reagent ion was used to selectively ionize and detect acids semi-continuously from 20–30 August 2011, with a measurement time resolution of ~1.5 h. At this site 98% of the organic acid mass is estimated to be in the gas-phase, with only ~2% in the particle phase. We investigated gas/particle partitioning, quantified as the fraction in the particle phase (Fp, of C1–C18 alkanoic acids, six known terpenoic acids and total bulk organic acids. Data were compared to the absorptive partitioning model and suggest that bulk organic acids at this site follow absorptive partitioning to the organic aerosol mass. The rapid response (<1–2 h of partitioning to temperature changes for bulk acids suggests that kinetic limitations to equilibrium are minor, which is in contrast to conclusions of some recent laboratory and field studies, possibly due to lack of very low ambient relative humidities at this site. Time trends for partitioning of individual and groups of acids were mostly captured by the model, with varying degrees of absolute agreement. Species with predicted substantial fractions in both the gas and particle phases show better absolute agreement, while species with very low predicted fractions in one phase often show agreement on trends, but poor absolute agreement, potentially due to thermal decomposition, inlet adsorption, or other issues. Based on measurement-model comparison we conclude that species carbon number and oxygen content, together with ambient temperature control the volatility of organic

  14. Semicontinuous measurements of gas-particle partitioning of organic acids in a ponderosa pine forest using a MOVI-HRToF-CIMS

    Science.gov (United States)

    Yatavelli, R. L. N.; Stark, H.; Thompson, S. L.; Kimmel, J. R.; Cubison, M. J.; Day, D. A.; Campuzano-Jost, P.; Palm, B. B.; Hodzic, A.; Thornton, J. A.; Jayne, J. T.; Worsnop, D. R.; Jimenez, J. L.

    2014-02-01

    Hundreds of gas- and particle-phase organic acids were measured in a rural ponderosa pine forest in Colorado, USA, during BEACHON-RoMBAS (Bio-hydro-atmosphere interactions of Energy, Aerosols, Carbon, H2O, Organics & Nitrogen - Rocky Mountain Biogenic Aerosol Study). A recently developed micro-orifice volatilization impactor high-resolution time-of-flight chemical ionization mass spectrometer (MOVI-HRToF-CIMS) using acetate (CH3C(O)O-) as the reagent ion was used to selectively ionize and detect acids semicontinuously from 20 to 30 August 2011, with a measurement time resolution of ~1.5 h. At this site 98% of the organic acid mass is estimated to be in the gas phase, with only ~2% in the particle phase. We investigated gas-particle partitioning, quantified as the fraction in the particle phase (Fp), of C1-C18 alkanoic acids, six known terpenoic acids, and bulk organic acids vs. carbon number. Data were compared to the absorptive partitioning model and suggest that bulk organic acids at this site follow absorptive partitioning to the organic aerosol mass. The rapid response (<1-2 h) of partitioning to temperature changes for bulk acids suggests that kinetic limitations to equilibrium are minor, which is in contrast to conclusions of some recent laboratory and field studies, possibly due to lack of very low ambient relative humidities at this site. Time trends for partitioning of individual and groups of acids were mostly captured by the model, with varying degrees of absolute agreement. Species with predicted substantial fractions in both the gas and particle phases show better absolute agreement, while species with very low predicted fractions in one phase often show poor agreement, potentially due to thermal decomposition, inlet adsorption, or other issues. Partitioning to the aqueous phase is predicted to be smaller than to the organic phase for alkanoic and bulk acids, and has different trends with time and carbon number than observed experimentally. This is due

  15. Semi-continuous measurements of gas/particle partitioning of organic acids in a ponderosa pine forest using a MOVI-HRToF-CIMS

    Science.gov (United States)

    Yatavelli, R. L. N.; Stark, H.; Thompson, S. L.; Kimmel, J. R.; Cubison, M. J.; Day, D. A.; Campuzano-Jost, P.; Palm, B. B.; Thornton, J. A.; Jayne, J. T.; Worsnop, D. R.; Jimenez, J. L.

    2013-06-01

    Hundreds of gas and particle phase organic acids were measured in a rural ponderosa pine forest in Colorado, USA, during the Bio-hydro-atmosphere interactions of Energy, Aerosols, Carbon, H2O, Organics and Nitrogen - Rocky Mountain Biogenic Aerosol Study (BEACHON-RoMBAS). A recently developed Micro-Orifice Volatilization Impactor High-Resolution Time-of-Flight Chemical Ionization Mass Spectrometer (MOVI-HRToF-CIMS) using acetate (CH3C(O)O-) as the reagent ion was used to selectively ionize and detect acids semi-continuously from 20-30 August 2011, with a measurement time resolution of ~1.5 h. At this site 98% of the organic acid mass is estimated to be in the gas-phase, with only ~2% in the particle phase. We investigated gas/particle partitioning, quantified as the fraction in the particle phase (Fp), of C1-C18 alkanoic acids, six known terpenoic acids and total bulk organic acids. Data were compared to the absorptive partitioning model and suggest that bulk organic acids at this site follow absorptive partitioning to the organic aerosol mass. The rapid response (<1-2 h) of partitioning to temperature changes for bulk acids suggests that kinetic limitations to equilibrium are minor, which is in contrast to conclusions of some recent laboratory and field studies, possibly due to lack of very low ambient relative humidities at this site. Time trends for partitioning of individual and groups of acids were mostly captured by the model, with varying degrees of absolute agreement. Species with predicted substantial fractions in both the gas and particle phases show better absolute agreement, while species with very low predicted fractions in one phase often show agreement on trends, but poor absolute agreement, potentially due to thermal decomposition, inlet adsorption, or other issues. Based on measurement-model comparison we conclude that species carbon number and oxygen content, together with ambient temperature control the volatility of organic acids and are good

  16. 石化企业CIMS工程关键技术研究%Research on Key technology of CIMS Engineering in Petrochemical Enterprise

    Institute of Scientific and Technical Information of China (English)

    王丽萍

    2002-01-01

    介绍了863/CIMS示范工程大庆石油化工总厂化工一厂CIMS工程(DQE-CIMS)的关键技术及解决方案.对DQE-CIMS工程的总体技术、网络技术、浏览器技术和数据库技术等进行详细论述.

  17. Field Measurements Of Ammonia Fluxes Above A Douglas-fir Forest In Speuld, Holland Using Chemical Ionization Mass Spectrometry (CIMS)

    Science.gov (United States)

    McGillen, M. R.; Gallagher, M. W.; Flynn, M. J.; Percival, C. J.

    2009-12-01

    Ammonia (NH3) is an important component of the atmospheric nitrogenous species on regional scales and is a major contributor to the nitrogen budget across the UK and Western Europe. It represents the major atmospheric alkaline gas and in its interaction with acidic gases such as nitric acid, leads to the formation of particulate matter (e.g., Asman, 1998). As sulphur emissions decline across Western Europe, regions of excess ammonia are becoming more widespread and ammonium nitrate aerosol is becoming a significant component of atmospheric nitrogen . NH3 is efficiently lost to the semi-natural vegetation, typical of many natural ecosystems prevalent in Western Europe. Deposition of atmospheric NH3 to ecosystems can lead to deleterious effects such as eutrophication and acidification of soils, contributing to forest decline and a decrease in biological diversity (e.g., Fangmeier et al., 1994). Ammonia measurements were performed using chemical ionization mass spectrometry (CIMS) utilizing the protonated acetone dimer as the precursor ion. NH3 flux measurements were evaluated using the eddy covariance technique at a height of 46m above ground at Speuld forest. The Speuld fieldsite is a mature plantation of Douglas-fir (Pseudotsuga menziesii), located in the centre of the Netherlands (52°13'N, 5 ° 39'E). Data was collected over a two week period (June 25th - July 8th 2009), and fluxes will be determined using the eddy covariance technique. To the authors’ knowledge, these measurements represent the only NH3 flux measurements using CIMS, indeed few studies exist that directly determine fluxes using the this technique. Eddy covariance flux measurements are the most direct way to estimate NH3 removal near the surface. Preliminary data will be presented and compared with the GRadient Ammonia High Accuracy Monitor (GRAHAM) method. References: Asman, W. A. H., Sutton, M. A., and Schjorring, J. K.: Ammonia: emission, atmospheric transport and deposition, New Phytol., 139

  18. CIMS环境下支持并行设计的PDM系统简介%Introduction to PDM System Used for Parallel Design in CIMS Environment

    Institute of Scientific and Technical Information of China (English)

    顾红; 宋鹏云

    2001-01-01

    随着全球经济一体化的发展,市场竞争日趋激烈。为确保在市场竟争中立于不败之地,实施计算机集成制造系统( CIMS)技术是其强有力的保证措施。而产品数据库管理( PDM)是实现 CIMS应用的关键技术之一。本文介绍和研究了 PDM系统原理和体系结构以及并行过程的要求,讨论了在 CIMS环境下,支持并行设计的PDM的总体技术方案。%With the development of the global economy integration, the market competition is more intense. To not be lost in the market, the execution of the computer integrated manufacture system (CIMS) is a strong competing method. The product database management (PDM) is the key technique in CIMS. In this article, the principles and system of PDM as well as the requirement of the parallel process were introduced and researched. Then, the global technique scheme of PDM that supports the parallel design in the CIMS environment was discussed.

  19. PATTERNS OF BREAST LESIONS IN PATIENTS ATTENDING CIMS, BILASPUR, C. G.: A RETROSPECTIVE TERTIARY HOSPITAL BASED STUDY

    Directory of Open Access Journals (Sweden)

    Arya

    2015-09-01

    Full Text Available The present study is designed to find out frequency of various histological patterns of breast lesions in patients attending Chhattisgarh Institute of Medical Sciences (CIMS, a teaching institute in Bilaspur Chhattisgarh and their biopsy samples studied i n department of pathology. A retrospective series study was conducted on 335 cases of breast lesions, reported from 2003 to 2014. Mean age of the subjects was 49.65 years with standard deviation 12.06 years, ranging from 12 to 75 years. In a total 335 cases, 40 (11.94% were non - neoplastic and 295(88.06% were neoplastic. Among neoplastic lesion s, 180(53.73% were benign, 02 (0.59% borderline and 113(33.73% found malignant. The commonest non - neoplastic lesion was fibrocystic disease of breast followed b y fibroadenosis and sclerosing adenosis. Neoplastic lesions were more common than non - neoplastic lesions. Among histological types of breast tumours, fibroadenoma dominated the other types. Thus commonest benign tumour was fibroadenoma followed by phyllode s tumour and commonest malignant was infiltrating duct carcinoma followed by medullary carcinoma. The commonest borderline tumour was phyllodes tumour with borderline changes.

  20. NCPP's Use of Standard Metadata to Promote Open and Transparent Climate Modeling

    Science.gov (United States)

    Treshansky, A.; Barsugli, J. J.; Guentchev, G.; Rood, R. B.; DeLuca, C.

    2012-12-01

    The National Climate Predictions and Projections (NCPP) Platform is developing comprehensive regional and local information about the evolving climate to inform decision making and adaptation planning. This includes both creating and providing tools to create metadata about the models and processes used to create its derived data products. NCPP is using the Common Information Model (CIM), an ontology developed by a broad set of international partners in climate research, as its metadata language. This use of a standard ensures interoperability within the climate community as well as permitting access to the ecosystem of tools and services emerging alongside the CIM. The CIM itself is divided into a general-purpose (UML & XML) schema which structures metadata documents, and a project or community-specific (XML) Controlled Vocabulary (CV) which constraints the content of metadata documents. NCPP has already modified the CIM Schema to accommodate downscaling models, simulations, and experiments. NCPP is currently developing a CV for use by the downscaling community. Incorporating downscaling into the CIM will lead to several benefits: easy access to the existing CIM Documents describing CMIP5 models and simulations that are being downscaled, access to software tools that have been developed in order to search, manipulate, and visualize CIM metadata, and coordination with national and international efforts such as ES-DOC that are working to make climate model descriptions and datasets interoperable. Providing detailed metadata descriptions which include the full provenance of derived data products will contribute to making that data (and, the models and processes which generated that data) more open and transparent to the user community.

  1. Alternativa terapeutica en la isquemia cerebral empleando la Eritropoyetina humana recombinante (rHu-EPO CIM como neuroprotector.

    Directory of Open Access Journals (Sweden)

    Iliana Sosa Testé

    2005-01-01

    Full Text Available Las enfermedades vasculares constituyen las terceras causas de muerte en Cuba. Su variante isquémica es causa de invalidez y perdida de la calidad de la vida. La búsqueda de agentes neuroprotectores es muy importante sí tenemos en cuenta que nuestra población está envejecida. Muchos son las razones por la que una molécula con propiedades neuroprotectoras en los modelos animales no tenga los resultados en ensayos clínicos en humanos. Este trabajo analiza y discute como mejorar estos aspectos. La Eritropoyetina humana recombinante (rHu EPO, conocido por su papel en la diferenciación del eritrocito, ha mostrado ser neuroprotector durante la isquemia cerebral en los modelos de animales adultos. De esta molécula se exponen los mecanismos de acción, que son las bases de los resultados positivos alcanzaron en las investigaciones preclínicas y los ensayos clínicos, que lo proponen como el neuroprotector ideal. Finalmente se comparan los resultados alcanzados por los autores en las investigaciones con la rHu EPO producida por el Centro Molecular de Inmunología de Cuba (CIM. El efecto de la aplicación de rHu EPO se evidenció por la disminución del edema cerebral, preservación de la conducta exploratoria y la disminución de la incidencia de señales clínicas de infarto cerebral y alteraciones patológicas. El grupo de resultados demostró las diferencias significantes entre los animales controles y tratados con el rHu EPO con los no tratados que sugieren que el rHu EPO debe ser considerado como una alternativa terapéutica contra el infarto cerebral en su fase aguda.

  2. 石油化工领域CIMS体系结构研究%Research of CIMS Architecture in the Petrochemical Field

    Institute of Scientific and Technical Information of China (English)

    张玉梅; 郭景峰

    2001-01-01

    以大庆石化总厂化工一厂的CIMS示范工程为例,论述石油化工领域计算机集成生产系统(Computer Integrated Manufacturing System, CIMS)的体系结构;以CIMS原理为指导,把CIMS工程的目标与企业长远发展战略相结合,给出了适合我国石油化工行业要求的CIMS的实施方案.

  3. MISSING CASES OF CANCER CERVIX IN NEWLY STARTED OUT PATIENT DEPARTMENT OF RADIOTHERAPY, CIMS, BILASPUR (C. G.

    Directory of Open Access Journals (Sweden)

    Hemlata

    2015-10-01

    Full Text Available BACKGROUND: C ancer of the cervix is the second most common cancer among women’s worldwide. In India also, cancer of cervix is second most common cancer among women’s and number one killer. Estimated incidence rate of 22/lac population . [1] C ancer cervix is difficult to cure once symptoms developed. Prognosis is strongly dependent upon the stage of cancer at the time of detection and treatment. In our institute CIMS, Bilaspur (C. G. newly form cancer unit start providing services from August 2013. In our Hospital registry a cross - sectional base line data were collected, it was eye opener that proportion of cancer of cervix registry are less as compared nationwide HBCR & PBCR programme. OBJECTIVE : 1. To find out the reason for low registration of cancer cervix cases in OPD of cancer Unit. 2. To developed / suggest appropriated screening program. MATERIAL AND METHOD S : Retrospective study was carried out to collect all information from - Year 2012 to June 2 015, from medical records & Registers of department of pathology, department of Obstratric & Gynaecology and Medical Record Department, information collected regarding cancer cervix patient in semi structured format and analysed by SPSS software to inquire about cancer of cervix patient. STATISTICAL ANALYSIS : Using SPSS software 11.5 version. Statistic were reported in form of frequency and percentages. RESULT : In this present study out of total diagnosed cervical cancer cases in our institute only 61.11% c ases reach up to radiotherapy department for registration and 38.88% cases are lost during referral and follow - up . Yield of cancer cervix screening camp was only 5.75% and OPD based screening 22.89% with cervical smear cytology, both figure are quit low as cytology is estimated to have a mean sensitivity of 58% and specificity of 69 % [2] both sampling and detection error probably contribute to low to moderate sensitivity of cytology. CONCLUSION: C oordination between

  4. Design and Implementation ofan Integrating Infrastructure forCIM Systems%一种CIM集成基础结构的设计与实现

    Institute of Scientific and Technical Information of China (English)

    邓胜春; 徐晓飞; 王念滨; 王刚

    2001-01-01

    Integrating infrastructure is the basic supportingenvironmentforCIM(computer integrated manu-facturing)systems.This paperintroduces the design and implementation ofan opening distributed CIM integrat-ing infrastructure,HIT-IIS.2,developed by HIT(Harbin Institute of Technology).The HIT-IIS.2 prototypeincludes the following service functions for CIM systems:business process control,enterprise activity control,resource management,definition and description,system information,communication managementand front-endinterface.Each service function is described in the paper.%在计算机集成制造系统中,CIM(computer integratedmanufacturing)集成基础结构是最主要的支撑环境之一.介绍了由哈尔滨工业大学设计和开发的开放式CIM集成基础结构——HIT-IIS.2.该原型系统为CIM系统提供了以下一些服务功能:经营过程控制、企业活动控制、资源管理、定义描述与维护、全局系统信息服务、通信管理以及系统前端接口等.详细描述其中的每一服务功能

  5. CLINICO - PATHOLOGICAL STUDY OF NON - NEOPLASTIC LESIONS IN SINO - NASAL CAVITY OF PATIENTS ATTENDING CIMS, BILASPUR (C. G.: A RETROSPECTIVE STUDY

    Directory of Open Access Journals (Sweden)

    Arya

    2015-10-01

    Full Text Available INTRODUCTION : The present study examined the patterns of sinonasal masses in biopsies received in department of pathology of Govt. CIMS, Bilaspur which is a tertiary care hospital of central eastern region of India and represents a tribal belt. During the study period, 91 biopsied reported were retrieved from the records and results analyzed. OBJECTIVE : This study is designed to find out patterns of benign lesions of nasal mass in patients attending Chhattisgarh Institute of Medical Sciences (CIMS, a teaching institute in Bilaspur Chhattisgarh. MATERIAL AND METHODS : 91 nasal biopsy records of March 2003 to August 2015 were reviewed. All the biopsy samples of patients were received and studied in department of pathology. RESULTS AND OBSERVATIONS : Average age of subjects reported as non - neoplastic lesions is found 19.69 years with standard deviation of 9.44, ranging from 6 to 47 years. Among 75 non - neoplastic lesions, 63 (84.00% reported as rhinosporidiosis, 10(13.33% non - specific inflammatory po lyp and 2 were (2.67% tuberculosis. CONCLUSION : Rhinosporidiosis encountered as most common non - neoplastic lesion and most patients affected were in younger age groups. The study concluded with the exceptionally higher prevalence of rhinosporidiosis obser ved in this region

  6. The Application of CIMS in Production Management for Shipbuilding%CIMS在造船生产管理中的应用

    Institute of Scientific and Technical Information of China (English)

    赵勇

    2012-01-01

    CIMS is short for the computer information management system, which has been widely applied to the field of modern manufacturing since 1990s. Shipbuilding industry is the area of strong planning. Especially in the depressed market environment and the fierce competition among enterprises, how to use modern tools, allocate the resource and seek for benefit is one of the measures which every shipbuilding enterprise has to take. Based on our company's actual application condition, this paper briefly describes the application of CIMS in the production management for shipbuilding.%CIMS是计算机集成制造系统的简称,上世纪九十年代起已经开始广泛应用于现代制造领域,而造船行业则属于计划性比较强的领域,尤其是在目前市场环境比较低迷,企业间竞争比较激烈的情况下,如何利用现代化的工具,做好资源调配,从管理中挖掘效益,是各个造船企业必将采取的手段之一,本文结合我公司的实际使用情况对此进行简要说明。

  7. Learning Transfer Principles in a Comprehensive Integration Model

    Science.gov (United States)

    Boitel, Craig; Farkas, Kathleen; Fromm, Laurentine; Hokenstad, M. C.

    2009-01-01

    In this article, the authors propose a comprehensive integration model (CIM) based on learning transfer principles that promote integration by systematically and multidimensionally linking coursework with field education. This model improves the integration of classroom and field instruction by specifying how content in each course and in the…

  8. High concentrations of N2O5 and NO3 observed in daytime with a TD-CIMS: chemical interference or a real atmospheric phenomenon?

    Directory of Open Access Journals (Sweden)

    X. Wang

    2013-08-01

    Full Text Available Dinitrogen pentoxide (N2O5 and the nitrate radical (NO3 play important roles in atmospheric chemistry, yet accurate measurements of their concentrations remain challenging. A thermal dissociation chemical ionization mass spectrometer (TD-CIMS was deployed to an urban site in Hong Kong to measure the sum of N2O5 and NO3 in autumn 2010. To our surprise, very high concentrations of N2O5 + NO3 were frequently observed in daytime, with mixing ratios in the range of 200–1000 pptv. To investigate this unusual phenomenon, various interference tests and measurements with different instrument configuration were conducted. It was found that peroxy acetyl nitrate (PAN contributed to measurable signals at 62 amu, and more importantly, this interference increased significantly with co-existence of NO2. Nitric acid (HNO3, on the other hand, had little interference to the detection of N2O5/NO3 via the NO3− ion in our TD-CIMS. According to the test results, the interference from PAN and NO2 could have contributed to 30–50% of the average daytime (12:00–16:00 LT N2O5 + NO3 signal at our site. However, evidence exists for the presence of elevated daytime N2O5, in addition to the daytime signal at 62 amu. This includes: (1 daytime N2O5 measured via the I(N2O5− cluster ion with an unheated inlet, which subjects to minimum interferences, and (2 observation of elevated daytime ClNO2 (a product of N2O5 hydrolysis during a follow-up study. In view of the difficulty in accurately quantifying the contribution from the interferences of PAN and NO2 and un-tested potential interfering chemicals in the real atmosphere, we caution the use of 62 amu in the TD-CIMS for measuring ambient N2O5 in a high NOx environment like Hong Kong. Additional studies are needed to re-examine the daytime issue using other measurement techniques.

  9. LAS COMUNICACIONES INTEGRADAS DE MARKETING (CIM COMO PILAR DE LA ESTRATEGIA DE MARKETING VERDE Y SUS IMPLICACIONES EN LA GESTIÓN AMBIENTAL

    Directory of Open Access Journals (Sweden)

    NELCY ROCÍO ESCOBAR MORENO

    2012-01-01

    Full Text Available Este documento examina el constructo de Comunicaciones Integradas de Marketing (CIM, desde su definición hasta su aplicación a partir de la perspectiva del mercadeo verde en la estrategia organizacional. El texto presenta tres grandes discusiones, primero, una reflexión particular sobre los aportes e implicaciones más importantes de las Comunicaciones Integradas de Marketing y de cada uno de sus instrumentos a la estrategia de gestión ambiental de las organizaciones. Luego, una caracterización general del consumidor verde y de otros stakeholders de la organización, en particular, de su papel en el proceso estratégico de la comunicación verde. Finalmente, como conclusión de este trabajo, se plantean algunas consideraciones sobre la necesaria aplicación de este concepto en la propuesta de gestión ambiental organizacional en la actualidad.

  10. 制造型企业的CIMS需求分析探究%Exploration on demand analysis of CIMS in manufacturing enterprise

    Institute of Scientific and Technical Information of China (English)

    张绪乾

    2011-01-01

    我国大部分制造型企业开发出的一些CIMS系统不能满足企业的需求,导致了CIMS工程的不同程度的风险和企业资源的浪费,企业要有效的实施CIMS,首先必须进行CIMS的需求分析,即在实施CIMS前必须详细地进行企业现状分析,找出企业存在的问题,以进行CIMS系统对策研究,并在湖北久隆公司实施CIMS应用工程的需求分析中进行了实践.

  11. Enhanced muscle shortening and impaired Ca2+ channel function in an acute septic myopathy model.

    Science.gov (United States)

    Friedrich, Oliver; Hund, Ernst; von Wegner, Frederic

    2010-04-01

    Myopathies in critically ill patients are increasingly documented. Various animal models of chronic sepsis have been employed to investigate reduced membrane excitability or altered isometric contractility of skeletal muscle. In contrast, immediate changes occurring during acute sepsis are significantly under-characterised; L-type Ca(2+) channel function or isotonic shortening are examples. We recorded slowly activating L-type Ca(2+) currents (I (Ca)) in voltage-clamped single intact mouse skeletal muscle fibres and tested the effects of acute challenge with serum fractions from critical illness myopathy patients (CIM). Using a high-speed camera system, we simultaneously recorded unloaded fibre shortening during isotonic contractions with unprecedented temporal resolution (approximately 1,600 frames/s). Time courses of fibre lengths and shortening velocity were determined from automated imaging algorithms. CIM fractions acutely induced depression of I (Ca) amplitudes with no shifts in I (Ca)-V-relations. Voltage-dependent inactivation was unaltered and I (Ca) activation and inactivation kinetics were prolonged compared to controls. Unexpectedly, maximum unloaded speed of shortening was slightly faster following CIM serum applications, suggesting a direct action of CIM serum on weak-binding-state cross-bridges. Our results are compatible with a model where CIM serum might acutely reduce a fraction of functional L-type Ca(2+) channels and could account for reduced SR Ca(2+) release and force production in CIM patients. Acute increase in isotonic shortening velocity might be an early diagnostic feature suitable for testing in clinical studies. The acute challenge model is also robust against atrophy or fibre type changes that ordinarily would have to be considered in chronic sepsis models.

  12. Simultaneous ground-based and airborne measurements of biogenic VOC oxidation products using iodide-adduct HR-ToF-CIMS in the Southeast U.S

    Science.gov (United States)

    Lee, B.; Mohr, C.; Lopez-Hilfiker, F.; Warneke, C.; Graus, M.; Gilman, J.; Lerner, B. M.; Pollack, I. B.; Ryerson, T. B.; Roberts, J. M.; Edwards, P. M.; Brown, S. S.; Holloway, J.; Aikin, K.; Dube, W. P.; Liao, J.; Welti, A.; Middlebrook, A. M.; Nowak, J. B.; Neuman, J. A.; Brioude, J. F.; McKeen, S. A.; Hanisco, T. F.; Kaiser, J.; Keutsch, F. N.; Wolfe, G. M.; Hallquist, M.; Trainer, M.; De Gouw, J. A.; Thornton, J. A.

    2013-12-01

    We present measurements by two high-resolution time-of-flight chemical-ionization mass spectrometers (HR-ToF-CIMS) during the Southeast Atmosphere Study in June and July of 2013. Both HR-ToF-CIMS used iodide as the reagent ion, which provides minimum fragmentation during ionization. Isoprene and monoterpene oxidation byproducts such as hydroxy hydroperoxides, carboxylic acids and organic nitrates, were ubiquitous in the mass spectra. In addition, we observed select inorganic gases such as N2O5 and ClNO2. The flight instrument was deployed aboard the NOAA WP-3D during SENEX, which explored the lower atmosphere over the Southeast U.S., logging a total of 125 flight hours. These measurements provide insight into the spatial and temporal variation of these types of compounds and the influence of natural gas fields, power plants, biomass burning, urban and biogenic emissions on their abundance under both day and nighttime conditions. The ground-based instrument was located near Brent, Alabama as part of the SOAS campaign and utilized the Filter Inlet for Gas and AEROsol (FIGAERO) - developed at the University of Washington - which allows measurement of both the gas and particle phases. Continuous observations spanning more than 4 weeks show the diurnal variability and the influence of meteorology and anthropogenic emissions on the gas-particle partitioning. Flights during SENEX over the ground site provide a unique opportunity to investigate the vertical distribution of a whole suite of these chemical species measured by these two cross-calibrated nearly identical instruments.

  13. Recovery of active anti TNF-α ScFv through matrix-assisted refolding of bacterial inclusion bodies using CIM monolithic support.

    Science.gov (United States)

    Sushma, Krishnan; Bilgimol, Chuvappumkal Joseph; Vijayalakshmi, Mookambeswaran A; Satheeshkumar, Padikara Kutty

    2012-04-01

    Anti TNF-α molecules are important as therapeutic agents for many of the autoimmune diseases in chronic stage. Here we report the expression and purification of a recombinant single chain variable fragment (ScFv) specific to TNF-α from inclusion bodies. In contrast to the conventional on column refolding using the soft gel supports, an efficient methodology using monolithic matrix has been employed. Nickel (II) coupled to convective interaction media (CIM) support was utilized for this purpose with 6M guanidine hydrochloride (GuHCl) as the chaotropic agent. The protein purified after solubilization and refolding proved to be biologically active with an IC₅₀ value of 15 μg. To the best of our knowledge, this is the first report showing the application of methacrylate based chromatographic supports for matrix-assisted refolding and purification of Escherichia coli inclusion bodies. The results are promising to elaborate the methodology further to exploit the potential positive features of monoliths in protein refolding science.

  14. Deployment of a ground-based CIMS apparatus for the detection of organic gases in the boreal forest during the QUEST campaign

    Directory of Open Access Journals (Sweden)

    K. Sellegri

    2005-01-01

    Full Text Available Measurements of atmospheric volatile organic compounds were performed in the Finnish Boreal forest atmosphere during spring 2003, as part of the project QUEST (Quantification of Aerosol Nucleation in the European Boundary Layer, using a ground-based Chemical Ionization Mass Spectrometer (CIMS instrument. Based on the study of their hydrate distribution, methanol, acetonitrile, acetaldehyde, dimethyl amine (DMA, ethanol/formic acid, acetone, trimethyl amine (TMA, propanol/acetic acid, isoprene, methyl vinyl ketone (MVK and metacrolein (MaCR, monoterpenes and monoterpene oxidation product (MTOP are proposed as candidates for masses 32, 41, 44, 45, 46, 58, 59, 60, 68, 70, 136, and 168amu, respectively. It would be, to our knowledge, the first time DMA, TMA and MTOP are measured with this method. Most compounds show a clear diurnal variation with a maximum in the early night, corresponding to the onset of the noctural inversion and in agreement with independant measurements of CO. Biogenic compounds are highly correlated with each other and the ratio monoterpene/oxidation product shows a typical daily pattern of nightime maxima. However, because isoprene mixing ratios are also maximum during the early night, it is likely that it suffers of the interference from another unidentified biogenic compound. Hence mass 68amu is identified as isoprene+compound X.

  15. Deployment of a ground-based CIMS apparatus for the detection of organic gases in the boreal forest during the QUEST campaign

    Directory of Open Access Journals (Sweden)

    K. Sellegri

    2004-07-01

    Full Text Available Measurements of atmospheric volatile organic compounds were performed in the Finnish Boreal forest atmosphere during spring 2003, as part of the project QUEST (Quantification of Aerosol Nucleation in the European Boundary Layer, using a ground-based Chemical Ionization Mass Spectrometer (CIMS instrument. Based on the study of their hydrate distribution, Methanol, Acetonitrile, Acetaldehyde, Dimethyl Amine (DMA, Ethanol/Formic Acid, Acetone, Trimethyl Amine TMA, Propanol/Acetic Acid, Methyl Vinyl Ketone (MVK and Metacrolein (MaCR, Monoterpenes, Cis-3-hexenyl Acetate and Monoterpene Oxidation Products (MTOP are proposed as candidates for masses 33, 41, 44, 45, 46, 58, 59, 60, 70, 136, 142 and 168 amu, respectively. It would be, to our knowledge, the first time DMA, TMA, MTOP and Cis-3-hexenyl Acetate are measured with this method. A compound with mass 68 amu, which could be Isoprene has also been identified. Most compounds show a clear diurnal variation with higher concentrations at night, starting at the onset of the nocturnal inversion and in agreement with independent measurements of CO. Biogenic compounds are highly correlated with each other and the ratio monoterpene/oxidation product shows a typical daily pattern of nighttime maxima. Cis-3-hexenyl Acetate has a diurnal variation similar to the ones of Isoprene and Monoterpenes, and especially close to the diurnal variation of their oxidation products.

  16. A high-resolution time-of-flight chemical ionization mass spectrometer utilizing hydronium ions (H3O+ ToF-CIMS) for measurements of volatile organic compounds in the atmosphere

    Science.gov (United States)

    Yuan, Bin; Koss, Abigail; Warneke, Carsten; Gilman, Jessica B.; Lerner, Brian M.; Stark, Harald; de Gouw, Joost A.

    2016-07-01

    Proton transfer reactions between hydronium ions (H3O+) and volatile organic compounds (VOCs) provide a fast and highly sensitive technique for VOC measurements, leading to extensive use of proton-transfer-reaction mass spectrometry (PTR-MS) in atmospheric research. Based on the same ionization approach, we describe the development of a high-resolution time-of-flight chemical ionization mass spectrometer (ToF-CIMS) utilizing H3O+ as the reagent ion. The new H3O+ ToF-CIMS has sensitivities of 100-1000 cps ppb-1 (ion counts per second per part-per-billion mixing ratio of VOC) and detection limits of 20-600 ppt at 3σ for a 1 s integration time for simultaneous measurements of many VOC species of atmospheric relevance. The ToF analyzer with mass resolution (m/Δm) of up to 6000 allows the separation of isobaric masses, as shown in previous studies using similar ToF-MS. While radio frequency (RF)-only quadrupole ion guides provide better overall ion transmission than ion lens system, low-mass cutoff of RF-only quadrupole causes H3O+ ions to be transmitted less efficiently than heavier masses, which leads to unusual humidity dependence of reagent ions and difficulty obtaining a humidity-independent parameter for normalization. The humidity dependence of the instrument was characterized for various VOC species and the behaviors for different species can be explained by compound-specific properties that affect the ion chemistry (e.g., proton affinity and dipole moment). The new H3O+ ToF-CIMS was successfully deployed on the NOAA WP-3D research aircraft for the SONGNEX campaign in spring of 2015. The measured mixing ratios of several aromatics from the H3O+ ToF-CIMS agreed within ±10 % with independent gas chromatography measurements from whole air samples. Initial results from the SONGNEX measurements demonstrate that the H3O+ ToF-CIMS data set will be valuable for the identification and characterization of emissions from various sources, investigation of secondary

  17. Potential for the speciation of Zn using fast protein liquid chromatography (FPLC) and convective interaction media (CIM) fast monolithic chromatography with FAAS and electrospray (ES)-MS-MS detection.

    Science.gov (United States)

    Svete, P; Milacic, R; Mitrovic, B; Pihlar, B

    2001-08-01

    Analytical procedures were developed for the speciation of Zn using fast protein liquid chromatography (FPLC), flame atomic absorption spectrometry (FAAS) and convective interaction media (CIM) fast monolithic chromatography with FAAS and electrospray (ES)-MS-MS detection. The investigation was performed on synthetic solutions (2 microg cm-3 Zn) of hydrated Zn2+ species and Zn complexes with citrate, oxalate and EDTA (ligand-to-Zn molar ratio 100:1) over a pH range from 5.4 to 7.4. It was found that Zn interacts with various buffers and the careful adjustment of the pH with diluted solutions of KOH is, therefore, required. FPLC separations were carried out on a Mono Q HR 5/5 strong anion-exchange column, applying an aqueous 1 mol dm(-3) NH4NO3 linear gradient elution over 15 min, at a flow rate of 1.0 cm3 min(-1). The separated Zn species were determined in 1.0 cm3 eluate fractions "off line" by FAAS. Speciation of Zn was also performed on a weak anion-exchange CIM DEAE fast monolithic disc by applying an aqueous 0.4 mol dm(-3) NH4NO3 linear gradient elution over 7.5 min, at a flow rate of 2.0 cm3 min(-1) and determination of the separated Zn species in 1.0 cm3 eluate fractions "off line" by FAAS. Zn-binding ligands in separated fractions were also characterized by electrospray (ES)-MS-MS analysis. The CIM DEAE disc was found to be more efficient in the separation of negatively charged Zn complexes than the Mono Q FPLC column. On the CIM DEAE disc Zn-citrate was separated from both Zn-oxalate and from Zn-EDTA. All these species were also separated from hydrated Zn2+, which was eluted with the solvent front. This method has an advantage over commonly used analytical techniques for the speciation of Zn which are only able to distinguish between labile and strong Zn complexes. Good repeatability of the measurements (RSD 2-4%), tested for six parallel determinations (2 microg cm(-3) Zn) of Zn-EDTA, Zn-citrate and Zn-oxalate was found at a pH of 6.4 on a CIM DAEA disc

  18. Pattern-based Automatic Translation of Structured Power System Data to Functional Models for Decision Support Applications

    DEFF Research Database (Denmark)

    Heussen, Kai; Weckesser, Johannes Tilman Gabriel; Kullmann, Daniel

    2013-01-01

    Improved information and insight for decision support in operations and design are central promises of a smart grid. Well-structured information about the composition of power systems is increasingly becoming available in the domain, e.g. due to standard information models (e.g. CIM or IEC61850...

  19. FA-SIFT study of reactions of protonated water and ethanol clusters with [alpha]-pinene and linalool in view of their selective detection by CIMS

    Science.gov (United States)

    Dhooghe, F.; Amelynck, C.; Rimetz-Planchon, J.; Schoon, N.; Vanhaecke, F.

    2010-02-01

    The use of protonated water clusters and protonated ethanol clusters as reagent ions has been evaluated for the resolution of an interference encountered in CIMS when measuring monoterpenes (C10H16) and linalool (C10H18O) simultaneously. To this end, the reactions of H3O+.(H2O)n (n = 1-3), (C2H5OH)mH+ (m = 1-3) and (C2H5OH.H2O)H+ with [alpha]-pinene and linalool have been characterized in a flowing afterglow-selected ion flow tube (FA-SIFT) instrument at a SIFT He buffer gas pressure of 1.43 hPa and a temperature of 298 K. All reactions with linalool were found to occur at the collision limit. The reaction of (C2H5OH)2H+ with [alpha]-pinene proceeds at half the collision rate and both the reactions of (C2H5OH)3H+ and H3O+.(H2O)3 with [alpha]-pinene have a very low rate constant. All other reactions involving [alpha]-pinene proceed at the collision rate. The reactions of H3O+.H2O, H3O+.(H2O)2, C2H5OH2+, (C2H5OH.H2O)H+ and (C2H5OH)2H+ with [alpha]-pinene mainly proceed by proton transfer. Additionally, ligand switching channels have been observed for the reactions of (C2H5OH)2H+ and H3O+.(H2O)2 with [alpha]-pinene. Protonated linalool was observed as a minor product for the reactions of (C2H5OH.H2O)H+ and H3O+.(H2O)n (n = 1-3) with linalool. For all linalool reactions, a contribution of the dissociative proton transfer product at m/z 137 was found and this ion was the main product ion for the reactions with H3O+.H2O, C2H5OH2+ and (C2H5OH.H2O)H+. For the (C2H5OH.H2O)H+/linalool reaction, ligand switching with both water and ethanol has been observed. Major ligand switching channels were observed for the reactions of (C2H5OH)2H+, (C2H5OH)3H+ and H3O+.(H2O)2 with linalool. Also, for the H3O+.(H2O)3/linalool reaction, several ligand switching channels have been observed. These results are discussed in view of their applicability for the selective detection of monoterpenes and linalool with CIMS instrumentation such as SIFT-MS, PTR-MS and APCI-MS.

  20. Measurement of Organic Acids Produced By The Gas-Phase Ozonolysis of Simple Olefins Using Chemical Ionization Mass Spectrometry (CIMS) as a Function of Temperature And Humidity

    Science.gov (United States)

    Percival, C. J.; Bacak, A.; Leather, K. E.; McGillen, M. R.

    2009-12-01

    Non-methane hydrocarbons (NMHCs) form an important trace component of the atmosphere and are of particular environmental interest because of their deleterious effects on air quality, their numerous (and potentially counteractive) effects on Earth’s climate system and their sophisticated semiochemical roles in the world’s ecosystems. NMHCs are also important precursors to the formation of secondary organic aerosol (SOA) (e.g. Pandis et al., 1991; Kavouras et al., 1999). The ozonolysis reactions of olefins result in complex menageries of products, of which the acids are ubiquitous. Although the gas phase acid concentrations are small, they are thought to be key species in SOA formation as a result of their low volatility (e.g., Ma et al., 2009). Despite this, the factors that control acid formation are not well understood, especially with regards to humidity and temperature. Acid yields will be measured using the newly commissioned EXTreme RAnge (EXTRA) chamber (Leather et al., 2009). EXTRA is a 125 L stainless steel chamber, which can be temperature controlled using a commercial chest freezer unit (for T ≤ -20 °C) or a purpose built oven for T > 25 °C. The EXTRA chamber can be operated at pressures from 10-3800 Torr and at temperatures from 180-473 K. The stainless steel chamber walls have been coated with PFA to minimize wall loss of radicals. Fans, located at both ends of the cylinder, promote rapid mixing of reactants. Six sample ports are located at either end of the chamber for connection to ADS-GC-ECD, CIMS and commercial sensors such as a Thermo Electron Corporation 49i Ozone Analyzer, an Edinburgh Instruments Gascard CO2 sensor and a Trace Analytical inc. RGA3 CO analyzer. Experiments will be performed as a function of atmospherically relevant temperatures (T= 180-300 K). The field CIMS has sub ppt(v) L.O.D.s with a sub 1 Hz time response so will enable products to be quantified at very low concentrations in real time. Acid products will be detected

  1. Charged Ising Model of Neutron Star Matter

    CERN Document Server

    Hasnaoui, K H O

    2012-01-01

    Background: The inner crust of a neutron star is believed to consist of Coulomb-frustrated complex structures known as "nuclear pasta" that display interesting and unique low-energy dynamics. Purpose: To elucidate the structure and composition of the neutron-star crust as a function of temperature, density, and proton fraction. Methods: A new lattice-gas model, the "Charged-Ising Model" (CIM), is introduced to simulate the behavior of neutron-star matter. Preliminary Monte Carlo simulations on 30^3 lattices are performed for a variety of temperatures, densities, and proton fractions. Results: Results are obtained for the heat capacity, pair-correlation function, and static structure factor for a variety of conditions appropriate to the inner stellar crust. Conclusions: Although relatively simple, the CIM captures the essence of Coulomb frustration that is required to simulate the subtle dynamics of the inner stellar crust. Moreover, the computationally demanding long-range Coulomb interactions have been pre-c...

  2. Harmonization of semantic data models of electric data standards

    OpenAIRE

    Nieves Sánchez, Juan Carlos; Ortega de Mues, Mariano; Espinoza, Angelina; Rodríguez Álvarez, Daniel

    2011-01-01

    According to the Electric Power Research Institute (EPRI) a common semantics model is necessary for achieving interoperability in the Smart Grid vision. In this paper, we present an outline of two influential International Electrotech-nical Commission Standards (CIM and IEC 61850) for building a common semantic model in a Smart Grid vision. In addition, we revise two representative approaches suggested by EPRI for harmonizing these standards in a common semantic model. The pros and cons betwe...

  3. The CMIP5 Model Documentation Questionnaire: Development of a Metadata Retrieval System for the METAFOR Common Information Model

    Science.gov (United States)

    Pascoe, Charlotte; Lawrence, Bryan; Moine, Marie-Pierre; Ford, Rupert; Devine, Gerry

    2010-05-01

    The EU METAFOR Project (http://metaforclimate.eu) has created a web-based model documentation questionnaire to collect metadata from the modelling groups that are running simulations in support of the Coupled Model Intercomparison Project - 5 (CMIP5). The CMIP5 model documentation questionnaire will retrieve information about the details of the models used, how the simulations were carried out, how the simulations conformed to the CMIP5 experiment requirements and details of the hardware used to perform the simulations. The metadata collected by the CMIP5 questionnaire will allow CMIP5 data to be compared in a scientifically meaningful way. This paper describes the life-cycle of the CMIP5 questionnaire development which starts with relatively unstructured input from domain specialists and ends with formal XML documents that comply with the METAFOR Common Information Model (CIM). Each development step is associated with a specific tool. (1) Mind maps are used to capture information requirements from domain experts and build a controlled vocabulary, (2) a python parser processes the XML files generated by the mind maps, (3) Django (python) is used to generate the dynamic structure and content of the web based questionnaire from processed xml and the METAFOR CIM, (4) Python parsers ensure that information entered into the CMIP5 questionnaire is output as CIM compliant xml, (5) CIM compliant output allows automatic information capture tools to harvest questionnaire content into databases such as the Earth System Grid (ESG) metadata catalogue. This paper will focus on how Django (python) and XML input files are used to generate the structure and content of the CMIP5 questionnaire. It will also address how the choice of development tools listed above provided a framework that enabled working scientists (who we would never ordinarily get to interact with UML and XML) to be part the iterative development process and ensure that the CMIP5 model documentation questionnaire

  4. New ways of innovation: an application of the Cyclical Innovation Model to the mobile telecom industry

    OpenAIRE

    Berkhout, A.J.G.; Van der Duin, P.

    2006-01-01

    New developments in the mobile telecom industry, such as growing transmisson bandwidth and sector-crossing business alliances, change the way in which mobile telco’s are innovating. Traditional innovation models, such as the well-known single-company linear model ('pipeline model'), do not describe anymore how innovation occurs in today's practice. An alternative way of looking at innovation is the boundary-crossing Cyclic Innovation Model (CIM). It views innovation processes as coupled 'cycl...

  5. Primary investigation on course reformation thought of higher vocational management information system based on enterprise CIMS%基于企业CIMS的高职管理信息系统课改思路初探

    Institute of Scientific and Technical Information of China (English)

    宋洁

    2014-01-01

    此文针对高职院校《管理信息系统》课程教学的现状,探讨在教学内容上如何引入企业CIMS的相关内容,使学生了解企业CIMS环境下的管理信息系统如何开发,对于教学工作以及学生今后的学习和工作都具有重要的实用价值和广阔的应用前景。%Based on the current situation of “Management Information System”course teaching in high vocational colleges ,this paper discusses how to introduce the enterprise CIMS related contents into the teaching contents so as to enable the students to understand how to develop the management informa-tion system in enterprise CIMS environment ,which has important practical value and wide application prospect for the teaching job and the future study and working of students .

  6. Comparison of Models Needed for Conceptual Design of Man-Machine Systems in Different Application Domains

    DEFF Research Database (Denmark)

    Rasmussen, Jens

    1986-01-01

    For systematic and computer-aided design of man-machine systems, a consistent framework is needed, i. e. , a set of models which allows the selection of system characteristics which serve the individual user not only to satisfy his goal, but also to select mental processes that match his resource...... of other domains, such as emergency management, CAD/CAM/CIM, and office systems, and describes the characteristic differences in model requirements and requirements for model development....

  7. A Fast Variational Approach for Learning Markov Random Field Language Models

    Science.gov (United States)

    2015-01-01

    our class of models. Learning undirected graphical models is challenging because of the global nor- malization constant, or partition function. We...503–528, 1989. Marcus, Mitchell P, Marcinkiewicz, Mary Ann, and San- torini, Beatrice. Building a large annotated corpus of english : The penn treebank...A Fast Variational Approach for Learning Markov Random Field Language Models Yacine Jernite JERNITE@CS.NYU.EDU CIMS, New York University, 251 Mercer

  8. Reseach of Supply Chain Modeling Technology

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The supply chain modeling technology is research. Firstly, the concept of supply chain and supply chain management is introduced. Secondly, enterprise-modeling methods, such as CIM-OSA, GIM-GRAI, PERA and ARIS, are analyzed and compared. The supply chain modeling technology is studied. Then the ARIS-based supply chain modeling method is proposed and the supply chain operation reference model is set up. Finally, the applications of ARIS-based supply chain modeling method in Shanghai Turbine Generator Co. Ltd. (STGC) is described in detail.

  9. Hybrid Simulation Modeling to Estimate U.S. Energy Elasticities

    Science.gov (United States)

    Baylin-Stern, Adam C.

    This paper demonstrates how an U.S. application of CIMS, a technologically explicit and behaviourally realistic energy-economy simulation model which includes macro-economic feedbacks, can be used to derive estimates of elasticity of substitution (ESUB) and autonomous energy efficiency index (AEEI) parameters. The ability of economies to reduce greenhouse gas emissions depends on the potential for households and industry to decrease overall energy usage, and move from higher to lower emissions fuels. Energy economists commonly refer to ESUB estimates to understand the degree of responsiveness of various sectors of an economy, and use estimates to inform computable general equilibrium models used to study climate policies. Using CIMS, I have generated a set of future, 'pseudo-data' based on a series of simulations in which I vary energy and capital input prices over a wide range. I then used this data set to estimate the parameters for transcendental logarithmic production functions using regression techniques. From the production function parameter estimates, I calculated an array of elasticity of substitution values between input pairs. Additionally, this paper demonstrates how CIMS can be used to calculate price-independent changes in energy-efficiency in the form of the AEEI, by comparing energy consumption between technologically frozen and 'business as usual' simulations. The paper concludes with some ideas for model and methodological improvement, and how these might figure into future work in the estimation of ESUBs from CIMS. Keywords: Elasticity of substitution; hybrid energy-economy model; translog; autonomous energy efficiency index; rebound effect; fuel switching.

  10. Methods Of Testing And Assessing The Technical Condition Of Chosen Building Structures Located In The Area Of The Auschwitz-Birkenau National Museum In Oświęcim

    Directory of Open Access Journals (Sweden)

    Kańka Stanisław

    2015-12-01

    Full Text Available The results presented in this article consider the means of assessing the technical condition of two selected buildings, i.e. prisoner barracks number 123 and 124, located at the Auschwitz-Birkenau State Museum in Oświęcim. The work was carried out within the framework of a research project involving the development of methods for preserving, securing and strengthening the structure of buildings, along with their substrate and finishes. The aim of the project was to gain a knowledge base reflecting the actual state of the existing facilities and, on that basis, develop preservation methods and ways to protect the existing facilities against further damage, while maintaining the current character.

  11. A Technique of Automatic Generation of Substation Wiring Diagram Based on CIM%一种基于CIM的厂站接线图自动生成技术

    Institute of Scientific and Technical Information of China (English)

    沙树名; 林峰

    2008-01-01

    以典型接线形式的图形排布为依据,提出了一种根据设备连接信息自动生成接线图的经验方法,即通过可扩展的典型接线形式的定义,借助于Oracle Spatial的网络分析功能,对公共信息模型(CIM)数据中有关厂站内的设备及连接关系的部分进行分析和匹配,按照匹配到的接线形式排布厂站内各设备的位置,从而自动生成接线图.

  12. Digital elevation modeling via curvature interpolation for LiDAR data

    Directory of Open Access Journals (Sweden)

    Hwamog Kim

    2016-03-01

    Full Text Available Digital elevation model (DEM is a three-dimensional (3D representation of a terrain's surface - for a planet (including Earth, moon, or asteroid - created from point cloud data which measure terrain elevation. Its modeling requires surface reconstruction for the scattered data, which is an ill-posed problem and most computational algorithms become overly expensive as the number of sample points increases. This article studies an effective partial differential equation (PDE-based algorithm, called the curvature interpolation method (CIM. The new method iteratively utilizes curvature information, estimated from an intermediate surface, to construct a reliable image surface that contains all of the data points. The CIM is applied for DEM for point cloud data acquired by light detection and ranging (LiDAR technology. It converges to a piecewise smooth image, requiring O(N operations independently of the number of sample points, where $N$ is the number of grid points.

  13. Proceedings of the 45. annual conference of metallurgists of CIM : interfacial phenomena in fine particle technology : the 6. UBC-McGill-UA international symposium on fundamentals of mineral processing in honor of Professor Janusz S. Laskowski

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Z.; Liu, Q. [Alberta Univ., Edmonton, AB (Canada). Dept. of Chemical and Materials Engineering] (eds.)

    2006-07-01

    This conference, organized by the Mineral Sciences and Engineering Section of the Metallurgical Society of CIM acknowledged that strong economic growth is the driving force behind record high productivity in the mining industry. The industry must strive to meet the higher demand for raw materials while facing the challenge of stringent environmental constraints. The continuing success of the mining industry will depend on efficient and environmentally sound mineral processing, particularly since the industry has been forced to exploit more complex forms of minerals given the gradual depletion of high-grade mineral resources. In addition to shortages in qualified personnel in mineral processing, the industry is currently facing a general reduction in basic research and training programs, resulting in deficiencies in technologies needed to process complex ores. World experts in mineral processing participated at this conference to share their novel research in fine particle processing, applications of atomic force microscopy, flotation research, particle interactions in mineral processing, flotation froths, grinding, rheology and sulphide flotation chemistry. The sessions of the conference were entitled: atomic force microscopy in flotation research particulate interactions; flotation froths, flocculation and dewatering; grinding and rheology surfactants; flotation froths, particle-bubble interactions; sulphide flotation; and, general flotation froths. The conference featured 37 presentations, of which 6 have been catalogued separately for inclusion in this database. refs., tabs., figs.

  14. Ocean and Coastal Modeling: Nonlinear Acoustic Propagation

    Science.gov (United States)

    2009-03-27

    Conference on Mathematics and Continuum Mechanics. ISBN: 978-989-95011-2-6, Centra Internacional de Matematica (CIM), 207-217, Porto- Portugal...forecasting - II . Calibration and Combination", Tellus, 57A, 234-252, 2005 Egbert, G.D and S.Y. Erofeeva, 2002: Efficient inverse modeling of barotropic...l*l CO — i £ Oj I II ^ c - - •"*••*" \\ ••% .FT . --...; :.. • \\;*»« •<»•**" --* V--/j*» .•. -• ’T?Z’.?£T:’ZZ

  15. Federation of UML models for cyber physical use cases

    Energy Technology Data Exchange (ETDEWEB)

    2016-10-05

    This method employs the concept of federation, which is defined as the use of existing models that represent aspects of a system in specific domains (such as physical and cyber security domains) and building interfaces to link all of domain models. Federation seeks to build on existing bodies of work. Some examples include the Common Information Models (CIM) maintained by the International Electrotechnical Commission Technical Committee 57 (IEC TC 57) for the electric power industry. Another relevant model is the CIM maintained by the Distributed Management Task Force (DMTF)? this CIM defines a representation of the managed elements in an Information Technology (IT) environment. The power system is an example of a cyber-physical system, where the cyber systems, consisting of computing infrastructure such as networks and devices, play a critical role in the operation of the underlying physical electricity delivery system. Measurements from remote field devices are relayed to control centers through computer networks, and the data is processed to determine suitable control actions. Control decisions are then relayed back to field devices. It has been observed that threat actors may be able to successfully compromise this cyber layer in order to impact power system operation. Therefore, future control center applications must be wary of potentially compromised measurements coming from field devices. In order to ensure the integrity of the field measurements, these applications could make use of compromise indicators from alternate sources of information such as cyber security. Thus, modern control applications may require access to data from sources that are not defined in the local information model. In such cases, software application interfaces will require integration of data objects from cross-domain data models. When incorporating or federating different domains, it is important to have subject matter experts work together, recognizing that not everyone has the

  16. Distinct muscle apoptotic pathways are activated in muscles with different fiber types a rat model of critical illness myopathy

    Science.gov (United States)

    Barnes, Benjamin T.; Confides, Amy L.; Rich, Mark M.; Dupont-Versteegden, Esther E.

    2015-01-01

    Critical illness myopathy (CIM) is associated with severe muscle atrophy and fatigue in affected patients. Apoptotic signaling is involved in atrophy and is elevated in muscles from patients with CIM. In this study we investigated underlying mechanisms of apoptosis-related pathways in muscles with different fiber type composition in a rat model of CIM using denervation and glucocorticoid administration (denervation and steroid-induced myopathy, DSIM). Soleus and tibialis anterior (TA) muscles showed severe muscle atrophy (40–60% of control muscle weight) and significant apoptosis in interstitial as well as myofiber nuclei that was similar between the two muscles with DSIM. Caspase-3 and −8 activities, but not caspase-9 and −12, were elevated in TA and not in soleus muscle, while the caspase-independent proteins endonuclease G (EndoG) and apoptosis inducing factor (AIF) were not changed in abundance nor differentially localized in either muscle. Anti-apoptotic proteins HSP70, −27, and apoptosis repressor with a caspase recruitment domain (ARC) were elevated in soleus compared to TA muscle and ARC was significantly decreased with induction of DSIM in soleus. Results indicate that apoptosis is a significant process associated with DSIM in both soleus and TA muscles, and that apoptosis-associated processes are differentially regulated in muscles of different function and fiber type undergoing atrophy due to DSIM. We conclude that interventions combating apoptosis with CIM may need to be directed towards inhibiting caspase-dependent as well as -independent mechanisms to be able to affect muscles of all fiber types. PMID:25740800

  17. Distinct muscle apoptotic pathways are activated in muscles with different fiber types in a rat model of critical illness myopathy.

    Science.gov (United States)

    Barnes, Benjamin T; Confides, Amy L; Rich, Mark M; Dupont-Versteegden, Esther E

    2015-06-01

    Critical illness myopathy (CIM) is associated with severe muscle atrophy and fatigue in affected patients. Apoptotic signaling is involved in atrophy and is elevated in muscles from patients with CIM. In this study we investigated underlying mechanisms of apoptosis-related pathways in muscles with different fiber type composition in a rat model of CIM using denervation and glucocorticoid administration (denervation and steroid-induced myopathy, DSIM). Soleus and tibialis anterior (TA) muscles showed severe muscle atrophy (40-60% of control muscle weight) and significant apoptosis in interstitial as well as myofiber nuclei that was similar between the two muscles with DSIM. Caspase-3 and -8 activities, but not caspase-9 and -12, were elevated in TA and not in soleus muscle, while the caspase-independent proteins endonuclease G (EndoG) and apoptosis inducing factor (AIF) were not changed in abundance nor differentially localized in either muscle. Anti-apoptotic proteins HSP70, -27, and apoptosis repressor with a caspase recruitment domain (ARC) were elevated in soleus compared to TA muscle and ARC was significantly decreased with induction of DSIM in soleus. Results indicate that apoptosis is a significant process associated with DSIM in both soleus and TA muscles, and that apoptosis-associated processes are differentially regulated in muscles of different function and fiber type undergoing atrophy due to DSIM. We conclude that interventions combating apoptosis with CIM may need to be directed towards inhibiting caspase-dependent as well as -independent mechanisms to be able to affect muscles of all fiber types.

  18. Implementation of WPDL Conforming Workflow Model

    Institute of Scientific and Technical Information of China (English)

    张志君; 范玉顺

    2003-01-01

    Workflow process definition language (WPDL) facilitates the transfer of workflow process definitions between separate workflow products. However, much work is still needed to transfer the specific workflow model to a WPDL conforming model. CIMFlow is a workflow management system developed by the National CIMS Engineering Research Center. This paper discusses the methods by which the CIMFlow model conforms to the WPDL meta-model and the differences between the WPDL meta-model and the CIMFlow model. Some improvements are proposed for the WPDL specification. Finally, the mapping and translating methods between the entities and attributes are given for the two models. The proposed methods and improvements are valuable as a reference for other mapping applications and the WPDL specification.

  19. Acid-yield measurements of the gas-phase ozonolysis of ethene as a function of humidity using Chemical Ionisation Mass Spectrometry (CIMS

    Directory of Open Access Journals (Sweden)

    K. E. Leather

    2012-01-01

    Full Text Available Gas-phase ethene ozonolysis experiments were conducted at room temperature to determine formic acid yields as a function of relative humidity (RH using the integrated EXTreme RAnge chamber-Chemical Ionisation Mass Spectrometry technique, employing a CH3I ionisation scheme. RHs studied were <1, 11, 21, 27, 30 % and formic acid yields of (0.07±0.01 and (0.41±0.07 were determined at <1 % RH and 30 % RH respectively, showing a strong water dependence. It has been possible to estimate the ratio of the rate coefficient for the reaction of the Criegee biradical, CH2OO with water compared with decomposition. This analysis suggests that the rate of reaction with water ranges between 1×10−12–1×10−15 cm3 molecule−1 s−1 and will therefore dominate its loss with respect to bimolecular processes in the atmosphere. Global model integrations suggest that this reaction between CH2OO and water may dominate the production of HC(OOH in the atmosphere.

  20. Based on NUREG/CR-7007 Guidelines for AP1000 Device Interface Module (CIM) and Diversiifcation Drive System (DAS) Diversity%基于NUREG/CR-7007导则的AP1000设备接口模块(CIM)和多样化驱动系统(DAS)多样性分析

    Institute of Scientific and Technical Information of China (English)

    张丰平

    2016-01-01

    AP1000核电厂采用多样化驱动系统(DAS)作为反应堆保护系统的多样性后备,两者之间的多样化程度对共模故障影响重大。本文基于NUREG/CR-7007导则对设备接口模块(CIM)和多样化驱动系统进行多样性分析和计算,确认满足NUREG/CR-7007的要求,为多样化系统的设计提供参考。%AP1000 nuclear power plant uses a Diverse Actuation System (DAS) as the diversity backup for the reactor protection system, the diversity between them is very important to the common cause failure (CCF). This paper performs a diversity evaluation of the Component Interface Module (CIM) and Diversity Actuation System (DAS) to verify it meet the requirement of NUREG/CR-7007 Guidance and provide reference for I&C system design.

  1. SOFTWARE RELIABILITY MODEL FOR COMPONENT INTERACTION MODE

    Institute of Scientific and Technical Information of China (English)

    Wang Qiang; Lu Yang; Xu Zijun; Han Jianghong

    2011-01-01

    With the rapid progress of component technology,the software development methodology of gathering a large number of components for designing complex software systems has matured.But,how to assess the application reliability accurately with the information of system architecture and the components reliabilities together has become a knotty problem.In this paper,the defects in formal description of software architecture and the limitations in existed model assumptions are both analyzed.Moreover,a new software reliability model called Component Interaction Mode (CIM) is proposed.With this model,the problem for existed component-based software reliability analysis models that cannot deal with the cases of component interaction with non-failure independent and non-random control transition is resolved.At last,the practice examples are presented to illustrate the effectiveness of this model

  2. Career Information in the mathematical sciences (CIMS)

    Energy Technology Data Exchange (ETDEWEB)

    Sterrett, A.

    1993-05-01

    In November of 1992, a CBMS Steering Committee for Career Information was appointed by the CBMS Council. An informal meeting of those members in attendance at the Annual Meeting of the MAA and the AMS was held in January, 1993. The first meeting was held on May 1, 2 in Washington, DC in conjunction with CBMS Council meeting. Information on existing career materials was provided to the Council at that time and Council reactions were obtained. These reactions, along with reviews of material by students, faculty members and counselors, were used by the Steering Committee to plan specific activities for the next 6--18 months. Three initiatives were given high priority: To produce and widely disseminate an annotated bibliography of career information relevant to the mathematical sciences; to remedy the lack of messages to junior high school students, parents, teachers and counselors on the importance of mathematics in finding good jobs in a technological society; and to encourage women and minorities to take all the mathematics that they can and to consider careers in which mathematics plays an important role.

  3. Central Computer IMS Processing System (CIMS).

    Science.gov (United States)

    Wolfe, Howard

    As part of the IMS Version 3 tryout in 1971-72, software was developed to enable data submitted by IMS users to be transmitted to the central computer, which acted on the data to create IMS reports and to update the Pupil Data Base with criterion exercise and class roster information. The program logic is described, and the subroutines and…

  4. An open data repository and a data processing software toolset of an equivalent Nordic grid model matched to historical electricity market data.

    Science.gov (United States)

    Vanfretti, Luigi; Olsen, Svein H; Arava, V S Narasimham; Laera, Giuseppe; Bidadfar, Ali; Rabuzin, Tin; Jakobsen, Sigurd H; Lavenius, Jan; Baudette, Maxime; Gómez-López, Francisco J

    2017-04-01

    This article presents an open data repository, the methodology to generate it and the associated data processing software developed to consolidate an hourly snapshot historical data set for the year 2015 to an equivalent Nordic power grid model (aka Nordic 44), the consolidation was achieved by matching the model׳s physical response w.r.t historical power flow records in the bidding regions of the Nordic grid that are available from the Nordic electricity market agent, Nord Pool. The model is made available in the form of CIM v14, Modelica and PSS/E (Siemens PTI) files. The Nordic 44 model in Modelica and PSS/E were first presented in the paper titled "iTesla Power Systems Library (iPSL): A Modelica library for phasor time-domain simulations" (Vanfretti et al., 2016) [1] for a single snapshot. In the digital repository being made available with the submission of this paper (SmarTSLab_Nordic44 Repository at Github, 2016) [2], a total of 8760 snapshots (for the year 2015) that can be used to initialize and execute dynamic simulations using tools compatible with CIM v14, the Modelica language and the proprietary PSS/E tool are provided. The Python scripts to generate the snapshots (processed data) are also available with all the data in the GitHub repository (SmarTSLab_Nordic44 Repository at Github, 2016) [2]. This Nordic 44 equivalent model was also used in iTesla project (iTesla) [3] to carry out simulations within a dynamic security assessment toolset (iTesla, 2016) [4], and has been further enhanced during the ITEA3 OpenCPS project (iTEA3) [5]. The raw, processed data and output models utilized within the iTesla platform (iTesla, 2016) [4] are also available in the repository. The CIM and Modelica snapshots of the "Nordic 44" model for the year 2015 are available in a Zenodo repository.

  5. Antimycobacterial activity evaluation and MIC determination of liophilizated hydroalcoholic extracts of Bixa orellana L., Bixaceae Avaliação da atividade antimicobacteriana e a determinação da CIM de extratos hidroalcoólicos liofilizados de Bixa orellana L., Bixaceae

    Directory of Open Access Journals (Sweden)

    Renata B. Silva

    2010-05-01

    Full Text Available Bixa orellana is used in popular medicine against several diseases. Extracts of its fruit, root and leaf presented antimicrobial activity, while seed extract showed negative results. This study aimed at verifying the antimycobacterial activity of B. orellanalyophilized hydroalcoholic extracts over Mycobacterium tuberculosis, and determine the Minimum Inhibitory Concentration against five bacteria. Antimycobacterial activity was determined by diffusion technique, while MIC was assessed by diffusion and colorimetric analysis. MICs were 0.3, 0.5 and 0.2 mg/mL respectively, for leaf, root and stem extracts, against M. tuberculosis. Stem's extract showed 1.2 mg/mL for B. cereus, 1.53 mg/mL for S. aureusand S. typhimurium, 4.50 mg/mL for P. aeruginosaand 8.01 mg/mL for P. mirabillis.Leaf extracts showed 0.66 mg/mL for P. aeruginosa, 0.94 mg/mL for P. mirabillis, 1.88 mg/mL for S. aureus, 3.95 mg/mL for B. cereusand 8.37 mg/mL for S. typhimurium. Root's extracts showed 0.25 mg/mL for P. aeruginosa,0.31 mg/mL for S. aureus, 0.62 mg/mL for S. typhimuriumand 3.00 mg/mL for B. cereusand P. mirabillis. Leaf and stem extracts showed antimycobacterial activity. MICs were lower in colorimetric analysis than in agar diffusion. Extracts revealed bacteriostatic activity against the five bacterial.Bixa orellana é usada na medicina popular em várias doenças. Extratos do fruto, raiz e folhas apresentaram atividade antimicrobiana, enquanto extratos do caule mostraram resultados negativos. Este estudo teve por objetivo verificar a atividade antimicobacteriana de extratos hidroalcoólicos liofilizados de B. orellanafrente Mycobacterium tuberculosis e determinar a Concentração Inibitória Mínima para cinco bactérias. A atividade antimicobacteriana foi determinada por difusão e a CIM por difusão e análise colorimétrica. As CIM foram 0,3, 0,5 e 0,2 mg/mL para os extratos de folhas, raiz e caule frente M. tuberculosis. Os extratos de caule demonstraram CIM de 1

  6. MODELING OF FMS BASED ON UML AND OPNS

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    As the main component of computer integrated manufacturing system (CIMS), flexible manufacturing system (FMS) should be an open system with reusability and extendibility. Moreover, as FMS is a complex asynchronos concurrent system, its model also should have the abilities to express the concurrency in the system and to analyze the behavior of the system. It is difficult to use any one method to model such a complex system as FMS. A modeling method using objectoriented modeling language—unified modeling language (UML) and objectoriented Petri nets (OPNs) is proposed. Class diagram in UML is used to represent the static relations among the objects in FMS. OPNs are used to model the dynamic behavior of the objects and conduct performance analysis. OPNs also can be used to identify the attributes and operations of the objects. The model can describe the system integrally and can be used to design FMS control software naturally. manufa cturing system (CIMS), flexible manufacturing system (FMS) should be an open sys tem with reusability and extendibility. Moreover, as FMS is a complex asynchrono us concurrent system, its model also should have the abilities to express the co ncurrency in the system and to analyze the behavior of the system. It is difficu lt to use any one method to model such a complex system as FMS. A modeling metho d using objectoriented modeling language—unified modeling language (UML) and objectoriented Petri nets (OPNs) is proposed. Class diagram in UML is used to represent the static relations among the objects in FMS. OPNs are used to model the dynamic behavior of the objects and conduct performance analysis. OPNs also can be used to identify the attributes and operations of the objects. The model can describe the system integrally and can be used to design FMS control softwar e naturally.

  7. Advanced Manufacturing Technologies (AMT): Composites Integrated Modeling Element

    Data.gov (United States)

    National Aeronautics and Space Administration — CIM encompassed computational methods, tools and processes that go into the materials, design, manufacturing and qualification of composite aerospace structures....

  8. 信息模型驱动的信息系统开发与元信息系统%Information Model Driven Development of Information System and Meta Information System

    Institute of Scientific and Technical Information of China (English)

    梁军; 何建邦

    2003-01-01

    The development of Information System has been experienced four phases: Computing Central ,Data Cen-tral,Object Central phase,and Model Central phase under developing. Information Model in UML will be the core ofdevelopment of Information System. In order to manage Information Model,Artifacts of system development (such asmodels, documents ,source codes and components),the development process and the running of information system,an information system of information systems,Meta Information System ,must be built. Meta Information Systemwill become a Computer Integrated Manufacture System (CIMS)of Software Enterprise.

  9. Description Model of Warehouse Architecture for Clinical Test at the Molecular Immunology Centre

    Directory of Open Access Journals (Sweden)

    Anthony Rafael Sotolongo León

    2012-05-01

    Full Text Available Accurate and detailed description of the architecture of computer systems is very important to achieve success in their development. As informatic solutions, data warehouses and software support decision-making in institutions that need to implement a detailed description of the architecture. Ralph Kimball proposes the aspects to be considered of the description and explains how it is done. There are specific models used to describe the architecture such as Kruchten 4 +1 views of meta-model or the Common Warehouse Metamodel (CWM however these models do not meet the need of the description that requires a data warehouse that integrates information from clinical trials of the Molecular Immunology Centre (CIM. In this paper we propose a model for describing the data warehouse architecture that fits the needs of the Molecular Immunology Center following the Kimball framework and using as UML 2.0 modeling language.

  10. Upregulation of the CaV 1.1-ryanodine receptor complex in a rat model of critical illness myopathy.

    Science.gov (United States)

    Kraner, Susan D; Wang, Qingbo; Novak, Kevin R; Cheng, Dongmei; Cool, David R; Peng, Junmin; Rich, Mark M

    2011-06-01

    The processes that trigger severe muscle atrophy and loss of myosin in critical illness myopathy (CIM) are poorly understood. It has been reported that muscle disuse alters Ca(2+) handling by the sarcoplasmic reticulum. Since inactivity is an important contributor to CIM, this finding raises the possibility that elevated levels of the proteins involved in Ca(2+) handling might contribute to development of CIM. CIM was induced in 3- to 5-mo-old rats by sciatic nerve lesion and infusion of dexamethasone for 1 wk. Western blot analysis revealed increased levels of ryanodine receptor (RYR) isoforms-1 and -2 as well as the dihydropyridine receptor/voltage-gated calcium channel type 1.1 (DHPR/Ca(V) 1.1). Immunostaining revealed a subset of fibers with elevation of RYR1 and Ca(V) 1.1 that had severe atrophy and disorganization of sarcomeres. These findings suggest increased Ca(2+) release from the sarcoplasmic reticulum may be an important contributor to development of CIM. To assess the endogenous functional effects of increased intracellular Ca(2+) in CIM, proteolysis of α-fodrin, a well-known target substrate of Ca(2+)-activated proteases, was measured and found to be 50% greater in CIM. There was also selective degradation of myosin heavy chain relative to actin in CIM muscle. Taken together, our findings suggest that increased Ca(2+) release from the sarcoplasmic reticulum may contribute to pathology in CIM.

  11. Avaliação das metodologias M.I.C.E.®, Etest® e microdiluição em caldo para determinação da CIM em isolados clínicos Evaluation of M.I.C.E.TM, Etest® and CLSI broth microdilution methods for antimicrobial susceptibility testing of nosocomial bacterial isolates

    Directory of Open Access Journals (Sweden)

    Eloiza Helena Campana

    2011-04-01

    Full Text Available INTRODUÇÃO: As fitas Oxoid® M.I.C.Evaluator® (M.I.C.E., Thermo Fisher Scientific, Basingstoke, UK, recém-lançadas no mercado brasileiro, representam uma alternativa rápida para a realização de testes de sensibilidade a antimicrobianos (TSA. OBJETIVO: Avaliar o desempenho da metodologia M.I.C.E. em relação à microdiluição em caldo (teste de referência e ao Etest® (BioMérieux, Marcy l'Étoile, France. Material e métodos: Foram selecionados 160 isolados bacterianos, sendo P. aeruginosa (20, Acinetobacter spp. (20, K. pneumoniae (20, E. coli (20, S. aureus (20, Staphylococcus coagulase-negativa (20, E. faecalis (20 e E. faecium (20. Os TSAs foram realizados por microdiluição em caldo, Etest e M.I.C.E., seguindo-se as recomendações do Clinical Laboratory Standards Institute (CLSI, 2009 e dos respectivos fabricantes. Os resultados foram interpretados segundo os critérios estabelecidos pelo CLSI e comparados por análise de regressão. RESULTADOS: Avaliando-se todas as combinações de antimicrobianos vs. a espécie bacteriana, o desempenho da metodologia M.I.C.E. foi muito bom, apresentando uma concordância geral (variação na concentração inibitória mínima [CIM] ± 1-log2 > 90%, exceto para cefotaxima (85% e vancomicina (76,3%, quando em comparação com os resultados da metodologia de referência. Quando comparado com o Etest, a metodologia M.I.C.E. apresentou concordância geral > 96%, com exceção para a combinação amoxicilina/ácido clavulânico (67,5%. CONCLUSÃO: Os resultados do TSA obtidos pela metodologia M.I.C.E. apresentaram boa correlação com aqueles obtidos pela microdiluição em caldo e pelo Etest, indicando que essa metodologia é uma alternativa rápida para a determinação da CIM pelos laboratórios de microbiologia clínica. Atenção especial deve ser dada á determinação da CIM para a combinação amoxicilina/ácido clavulânico.INTRODUCTION: The Oxoid® M.I.C.EvaluatorTM methodology (M

  12. Derivation of hydroperoxyl radical (HO2) levels at an urban site via measurement of pernitric acid (HO2NO2) by iodide chemical ionization mass spectrometry (I(-)-CIMS).

    Science.gov (United States)

    Chen, Dexian; Huey, L Gregory; Tanner, David J; Li, Jianfeng; Ng, Nga Lee; Wang, Yuhang

    2017-02-17

    Hydroperoxyl radical (HO2) is a key species to atmospheric chemistry. At warm temperatures, the hydroperoxyl radical (HO2) and NO2 come to a rapid steady state with pernitric acid (HO2NO2). This paper presents the derivation of HO2 from observations of HO2NO2 and NO2 in metropolitan Atlanta, US in winter 2014 and summer 2015. HO2 was observed to have a diurnal cycle with morning concentrations suppressed by high NO from the traffic. At night, derived HO2 levels were nonzero and exhibited correlations with O3 and NO3, consistent with previous studies that ozonolysis and oxidation by NO3 are sources of nighttime HO2. Measured and model calculated HO2 were in reasonable agreement: Without the constraint of measured HO2NO2 , the model reproduced HO2 with a model-to-observed ratio (M/O) 1.27 (r = 0.54) for winter, 2014, and 0.70 (r = 0.80) for summer, 2015. Adding measured HO2NO2 as a constraint, the model predicted HO2 with M/O = 1.13 ((r = 0.77) for winter 2014, and 0.90 ((r = 0.97) for summer 2015. These results demonstrate the feasibility of deriving HO2 from HO2NO2 measurements in warm regions where HO2NO2 has a short lifetime.

  13. Parametric Modelling (bim) for the Documentation of Vernacular Construction Methods: a Bim Model for the Commissariat Building, Ottawa, Canada

    Science.gov (United States)

    Fai, S.; Filippi, M.; Paliaga, S.

    2013-07-01

    Whether a house of worship or a simple farmhouse, the fabrication of a building reveals both the unspoken cultural aspirations of the builder and the inevitable exigencies of the construction process. In other-words, why buildings are made is intimately and inevitably associated with how buildings are made. Nowhere is this more evident than in vernacular architecture. At the Carleton Immersive Media Studio (CIMS) we are concerned that the de-population of Canada's rural areas, paucity of specialized tradespersons, and increasing complexity of building codes threaten the sustainability of this invaluable cultural resource. For current and future generations, the quantitative and qualitative values of traditional methods of construction are essential for an inclusive cultural memory. More practically, and equally pressing, an operational knowledge of these technologies is essential for the conservation of our built heritage. To address these concerns, CIMS has launched a number of research initiatives over the past five years that explore novel protocols for the documentation and dissemination of knowledge related to traditional methods of construction. Our current project, Cultural Diversity and Material Imagination in Canadian Architecture (CDMICA), made possible through funding from Canada's Social Sciences and Humanities Research Council (SSHRC), explores the potential of building information modelling (BIM) within the context of a web-based environment. In this paper, we discuss our work-to-date on the development of a web-based library of BIM details that is referenced to ''typical'' assemblies culled from 19C and early 20C construction manuals. The parametric potential of these ''typical'' details is further refined by evidence from the documentation of ''specific'' details studied during comprehensive surveys of extant heritage buildings. Here, we consider a BIM of the roof truss assembly of one of the oldest buildings in Canada's national capital - the

  14. Automatic Graphing Algorithm for Primary Electric Wiring Diagram of Substation and Distribution Feeder Based on CIM%基于CIM的变电站与配电馈线一次接线图自动绘制算法

    Institute of Scientific and Technical Information of China (English)

    周博曦; 孟昭勇; 王志臣; 姜维; 万全

    2012-01-01

    基于IEC61970/IEC61968的公共信息模型规范,建立了关于配电网一次系统的数据服务平台;介绍了变电站内电压等级与间隔容器的分类及其类型识别方法。在图形布局时,对变电站采用分而治之的思想,递归地布局子容器;针对馈线辐射状或弱环状的特点,采用树形布局法;图形布局过程结合深度优先搜索法和堆栈技术。提出的自动绘图方法可使配电网中不同应用系统之间实现高度的图形与数据资源共享。%The data service platform for primary system of distribution network is established based on IEC 61970/IEC 61968 common information model (CIM), and the classification and type identification methods of voltage level and bay container in substation are introduced. For graphic arrangement, division thoughts is adopted to deal With substation and sub-containers arrange recursively. And the tree layout method is used to handle distribution feeders for their characteristics of radial or weak ring shape. Depth-first search and stack technology are combined to complete graphic arrangement. The automatic graphing method proposed is feasible for high degree of sharing graphs and data resources among different application systems of distribution network.

  15. DanGrid. Report from working group 23. Information model for dissemination data. [Smart grid in Denmark]; DanGrid. Delrapport. Arbejdsgruppe 23. Informationsmodel for formidling af data

    Energy Technology Data Exchange (ETDEWEB)

    Baadsgaard Trolle, M.; Tackie, D.V. [Dansk Energi, Frederiksberg (Denmark); Preben Nyeng, P.; Johansen, K. [Energinet.dk, Fredericia (Denmark); Knudsen, Hans [DONG Energy, Virum (Denmark); Fabricius Nielsen, J. [SEAS-NVE, Svinninge (Denmark)

    2012-09-15

    The mandate of the working group was to submit a consolidated recommendation to information models, that ensure that both technical and commercial players in the power system can easily communicate data between the players. This is to ensure that there are no artificial barriers between power systems operators in that for instance equipment is installed that do not comply with international standards. Based on the analysis of generic processes in the present and future intelligent power system in the five different process phases - agreements, forecasts, activation, metering and billing - it is recommended that the two basic information models Logical Nodes and CIM with corresponding IEC standard series form the backbone in a Danish information model for the exchange of data between the electricity sector operators in the intelligent grid. (LN)

  16. Introduction to Ant Colony Algorithm and Its Application in CIMS

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Ant colony algorithm is a novel simulated ecosystem e volutionary algorithm, which is proposed firstly by Italian scholars M.Dorigo, A . Colormi and V. Maniezzo. Enlightened by the process of ants searching for food , scholars bring forward this new evolutionary algorithm. This algorithm has sev eral characteristics such as positive feedback, distributed computing and stro nger robustness. Positive feedback and distributed computing make it easier to find better solutions. Based on these characteristics...

  17. Virtual Reality in Engineering Education: A CIM Case Study

    Science.gov (United States)

    Erenay, Ozan; Hashemipour, Majid

    2003-01-01

    Instructors in technical schools, polytechnics, and universities of technology must continually help students find the links between theory and practice. Students often don't recognize the links among the various subjects they study, or the links among the various tasks they perform as they study. It is well known that students learn best by…

  18. Observations of nitryl chloride and modeling its source and effect on ozone in the planetary boundary layer of southern China

    Science.gov (United States)

    Wang, Tao; Tham, Yee Jun; Xue, Likun; Li, Qinyi; Zha, Qiaozhi; Wang, Zhe; Poon, Steven C. N.; Dubé, William P.; Blake, Donald R.; Louie, Peter K. K.; Luk, Connie W. Y.; Tsui, Wilson; Brown, Steven S.

    2016-03-01

    Nitryl chloride (ClNO2) plays potentially important roles in atmospheric chemistry, but its abundance and effect are not fully understood due to the small number of ambient observations of ClNO2 to date. In late autumn 2013, ClNO2 was measured with a chemical ionization mass spectrometer (CIMS) at a mountain top (957 m above sea level) in Hong Kong. During 12 nights with continuous CIMS data, elevated mixing ratios of ClNO2 (>400 parts per trillion by volume) or its precursor N2O5 (>1000 pptv) were observed on six nights, with the highest ever reported ClNO2 (4.7 ppbv, 1 min average) and N2O5 (7.7 ppbv, 1 min average) in one case. Backward particle dispersion calculations driven by winds simulated with a mesoscale meteorological model show that the ClNO2/N2O5-laden air at the high-elevation site was due to transport of urban/industrial pollution north of the site. The highest ClNO2/N2O5 case was observed in a later period of the night and was characterized with extensively processed air and with the presence of nonoceanic chloride. A chemical box model with detailed chlorine chemistry was used to assess the possible impact of the ClNO2 in the well-processed regional plume on next day ozone, as the air mass continued to downwind locations. The results show that the ClNO2 could enhance ozone by 5-16% at the ozone peak or 11-41% daytime ozone production in the following day. This study highlights varying importance of the ClNO2 chemistry in polluted environments and the need to consider this process in photochemical models for prediction of ground-level ozone and haze.

  19. Present status and amendable subjects of brewery CIM. Beer kojo ni okeru CIM no genjo to kadai

    Energy Technology Data Exchange (ETDEWEB)

    Eguchi, T.; Kimura, T. (Asahi Breweries, Ltd., Tokyo (Japan))

    1991-12-10

    Though the beer consumption is being smoothly increased, there has been a considerable change in consumers prime taste of beer for these several years. The present report exhibits the computer integrated manufacturing system introduced in Ibaraki Brewery, Asahi Beer to be operated as per the target. The introduction of that system aimed at an execution of integrated administration, high particularly in quality control, to integrate the information and control of total production activities from the production planning to the product delivery. Together with the structuring of information system for the integrated production, aim was taken also at the heightening in quality control, heightening in administration level, labor saving and newly conceived distribution system. As for the structuring of hardware, the system was functionally classified into production planning level, administration level for the manufacturing and distribution, and control level for the processing and distribution. Each of those levels was accommodated with the most suitable machinery thereon. The future problems are about the quality control data measurement and widened application of database. 5 figs.

  20. Information Technology Model for Product Lifecycle Engineering

    Directory of Open Access Journals (Sweden)

    Bhanumathi KS

    2013-02-01

    Full Text Available An aircraft is a complex, multi-disciplinary, system-engineered product that requires real-time global technical collaboration through its life-cycle. Engineering data and processes which form the backbone of the aircraft should be under strict Configuration Control (CC. It should be model-based and allow for 3D visualization and manipulation. This requires accurate, realtime collaboration and concurrent engineering-based business processes operating in an Integrated Digital Environment (IDE. The IDE uses lightweight, neutral Computer Aided Design (CAD Digital Mock-Up (DMU. The DMU deals with complex structural assemblies and systems of more than a hundred thousand parts created by engineers across the globe, each using diverse CAD, Computer Aided Engineering (CAE, Computer Aided Manufacturing (CAM, Computer Integrated Manufacturing (CIM, Enterprise Resource Planning (ERP, Supply Chain Management(SCM,Customer Relationship Management(CRM and Computer Aided Maintenance Management System (CAMMS systems. In this paper, a comprehensive approach to making such an environment a reality is presented.

  1. Didactic model of the high storage system

    Directory of Open Access Journals (Sweden)

    J. Świder

    2006-04-01

    Full Text Available Purpose: The continuous progress in Computer Integrated Manufacturing (CIM field with automatic storing systems is broadening the range of education process for engineers in future. This document describes the newest didactic station integrated witch a Modular Production System (MPS model [1, 2, 3]. It is a module of high storage. This arrangement is the perfect didactic item for students.Design/methodology/approach: The main reason, why the laboratory position, we have mentioned, has been created is brodening the students knowlegde’s range. To achive this task the warehouse has been made from really industrial elements. All manipulator’s axis were building from different types of transmissions. Findings: During the work with warehouse there has been prepared the new algorithm which controlls the linear drive. Besides that there has been created brand new standards in engineers education, which are based on the described warehouse. Research limitations/implications: The main target of the didactic activity of Institute of Engineering Processes Automation and Integrated Manufacturing Systems is broden the loboratory base. That’s the reason why now there already has been building another laboratory position, which is based on Fanuc manipulator.Practical implications: The algorithm of Pneu-Stat steering hasn’t been finished yet, but when it has been done it can be used in industrial aplicationsOriginality/value: This paper describes the new didactic station with innovational steering algorithm [4, 5].

  2. Design and implementation of power enterprises common data model based on IEC standards%基于IEC标准的电力企业公共数据模型的设计与实现

    Institute of Scientific and Technical Information of China (English)

    王家凯; 王继业

    2011-01-01

    电力信息化在电力企业的发展过程中尤为重要,随着信息化步伐的加快,数据交换和共享的标准化、规范化要求也越来越迫切.标准化数据交换模型遵循IEC 61970标准,结合我国电力企业建设的发展状况而建立,已成为解决上述问题的重要途径.通过对IEC 61970标准中的公共信息模型(CIM)的分析,采用统一建模语言(UML)对其描述.并进行统一的部署和管理控制,以满足各业务系统之间的数据交换需求,解决电力企业数据中心建设中数据集成的标准化问题.%Power information is very important to the development of electric power enterprises. With the rapid development of information technology, the demand for standardization of data exchange and sharing increases more and more. Standardized data exchange model which follows international standards IEC 61970, combined with the development of China power enterprises, has become an important way to resolve this issue. This paper analyzes the Common Information Model (CIM) in IEC 61970 standard, describes the model by using Unified Modeling Language (UML), arranges and controls the model globally, to meet the demand of data exchange in various business application systems, and to solve the standardization problem of data integration in the construction of electric power enterprises data center.

  3. Models

    DEFF Research Database (Denmark)

    Juel-Christiansen, Carsten

    2005-01-01

    Artiklen fremhæver den visuelle rotation - billeder, tegninger, modeller, værker - som det privilligerede medium i kommunikationen af ideer imellem skabende arkitekter......Artiklen fremhæver den visuelle rotation - billeder, tegninger, modeller, værker - som det privilligerede medium i kommunikationen af ideer imellem skabende arkitekter...

  4. Automated debug for common information model defect using natural language processing algorithm%基于自然语言处理的通用信息模型自动调试

    Institute of Scientific and Technical Information of China (English)

    项炜

    2013-01-01

    Common Information Model (CIM) is an open industrial standard, which has been implemented in products of many companies. Meanwhile, there are lots of bugs being reported and fixed. In order to reduce the cost time and effort of finding the root cause, in this paper, a method to debug automatically was proposed based on natural language processing algorithm. It firstly segmented those sentences using maximum entropy model, then used simHash to find the most similar fixed bug based on specifically constructed dictionary, finally used text mining to find the root cause and solution via analyzing the trace provided by customer. The experimental result achieves 87. 5% accuracy, which shows its effectiveness.%通用信息模型(CIM)是工业界的一种公开标准,并已实现于很多产品中,大量的bug被发现和修复.为了减少了人工查找错误根源所需的时间和精力,提出一种基于自然语言处理的方法对CIM的bug进行自动调试.首先使用最大熵模型对已解决bug的文档描述进行分词,然后基于构建的词典使用simHash找出那些重复性很大的已修复的bug,最后使用文档处理的方法分析客户提供的trace找出问题所在和解决方法.实验结果取得了87.5%准确率,表明了该方法的有效性.

  5. Monitoring of MMCA-based Military Electronic Information System

    Institute of Scientific and Technical Information of China (English)

    ZHANG De-yu,; PAN Cheng-sheng; YANG Jing-yu

    2005-01-01

    A multiplex monitoring and control architecture (MMCA) for military supervision based on common information model (CIM) is put forward after analyzing the features of military system. Information format based on CIM can be compatible with other protocols by mapping data type into that of SNMP, DMI and CMIP, etc. And in order to realize transparence and dynamic expansibility of MMCA administrator, CIM object manager and CIM object provider are designed based on monitoring mechanism of agent extensibility--AgentX that MMCA agent uses.

  6. CREATING PRODUCT MODELS FROM POINT CLOUD OF CIVIL STRUCTURES BASED ON GEOMETRIC SIMILARITY

    Directory of Open Access Journals (Sweden)

    N. Hidaka

    2015-05-01

    Full Text Available The existing civil structures must be maintained in order to ensure their expected lifelong serviceability. Careful rehabilitation and maintenance planning plays a significant role in that effort. Recently, construction information modelling (CIM techniques, such as product models, are increasingly being used to facilitate structure maintenance. Using this methodology, laser scanning systems can provide point cloud data that are used to produce highly accurate and dense representations of civil structures. However, while numerous methods for creating a single surface exist, part decomposition is required in order to create product models consisting of more than one part. This research aims at the development of a surface reconstruction system that utilizes point cloud data efficiently in order to create complete product models. The research proposes using the application of local shape matching to the input point clouds in order to define a set of representative parts. These representative parts are then polygonized and copied to locations where the same types of parts exist. The results of our experiments show that the proposed method can efficiently create product models using input point cloud data.

  7. Complementary and integrative medicine for breast cancer patients - Evidence based practical recommendations.

    Science.gov (United States)

    Witt, C M; Cardoso, M J

    2016-08-01

    On average half of the breast cancer patients' population uses complementary and integrative medicine (CIM) therapies and many of them would like to receive information on CIM from their conventional treatment team. However, often they don't feel comfortable in discussing CIM related questions, with their conventional treatment team, because they think they don't have enough expertise and available time to deal with this topic. Furthermore, information on the evidence of CIM is not easily accessible and the available information is not always reliable. The purpose of the current paper is to provide: 1) an overview about the CIM interventions that have shown positive effects in breast cancer patients and might be useful in supportive cancer care, 2) practical guidance on how to choose and find a qualified referral to a CIM treatment: 3) recommendations on how these interventions could be integrated into Breast Cancer Centers and which factors should be taken into consideration in this setting. This paper takes available CIM practice guidelines for cancer patients and previous research on CIM implementation models into account. There are CIM interventions that have shown a potential to reduce symptoms of cancer or cancer treatments in breast cancer patients and the vast majority uses a non-pharmacological approach and have a good potential for implementation. Nevertheless, further and more rigorous research is still needed.

  8. Observations of Nitryl Chloride and Modeling its Source and Effect on Ozone in the Planetary Boundary Layer of Southern China

    Science.gov (United States)

    LI, Q.; Wang, T.; Tham, Y. J.; Xue, L.; Zha, Q.; Wang, Z.; Poon, S.; Brown, S. S.; Dube, W. P.; Louie, P. K. K.; Luk, C.; Blake, D. R.; Tsui, W.

    2015-12-01

    Nitryl chloride (ClNO2) is produced from heterogeneous reaction of N2O5 on chloride-containing aerosol. ClNO2 can impact the oxidative capacity of the atmosphere by production of highly reactive chlorine radical (Cl) and recycling NOx after its photolysis. Subsequent reactions between Cl and volatile organic compounds may enhance photochemical formation of ozone. Despite the potentially important roles of ClNO2 in atmospheric chemistry, its abundance and effect are not well understood in some parts of the world. In late autumn 2013, ClNO2 was measured with a chemical ionization mass spectrometer (CIMS) at a mountain top (957 m a.s.l) in Hong Kong. During 12 nights with continuous CIMS data, elevated concentrations of ClNO2 (>400 ppbv) or its precursor N2O5 (>1000 pptv) were observed on six nights, with the highest ever reported ClNO2 (4.7 ppbv) and N2O5 (7.7 ppbv) in one case. Backward particle dispersion calculations driven by winds simulated with a mesoscale meteorological model show that the ClNO2/N2O5-laden air at the high-elevation site was due to transport of urban/industrial pollution north of the site. The highest ClNO2/N2O5 case was observed in a later period of the night and was characterized with extensively processed air and with the presence of non-oceanic chloride. A chemical box model with detailed chlorine chemistry was used to assess the possible impact of the ClNO2 in the well-processed regional plume on next-day ozone as the air mass continued to downwind locations. The results show that the ClNO2 could enhance ozone up to 23 ppbv or a 22% increase at the ozone peak in the following day. This study demonstrates the importance of the ClNO2 chemistry in polluted environments and highlights the need to consider this process in photochemical models for prediction of ground-level ozone and haze.

  9. Machine Tool Advanced Skills Technology (MAST). Common Ground: Toward a Standards-Based Training System for the U.S. Machine Tool and Metal Related Industries. Volume 14: Automated Equipment Technician (CIM), of a 15-Volume Set of Skill Standards and Curriculum Training Materials for the Precision Manufacturing Industry.

    Science.gov (United States)

    Texas State Technical Coll., Waco.

    This document is intended to help education and training institutions deliver the Machine Tool Advanced Skills Technology (MAST) curriculum to a variety of individuals and organizations. MAST consists of industry-specific skill standards and model curricula for 15 occupational specialty areas within the U.S. machine tool and metals-related…

  10. Computer Integrated Manufacture System (CIMS/CIPS) (to be continued)%计算机集成制造(生产)系统(CIMS/CIPS)

    Institute of Scientific and Technical Information of China (English)

    史有群; 许世范

    1999-01-01

    @@ 4 计算机网络计算模式的发展 计算机网络计算模式的发展经历了集中式大型机、PC/文件服务器、客户/服务器3个阶段,目前随着Internet和Intranet技术的发展正进入Web浏览器/服务器模式(Browser/Server)阶段.

  11. Modeling the Detection of Organic and Inorganic Compounds Using Iodide-Based Chemical Ionization.

    Science.gov (United States)

    Iyer, Siddharth; Lopez-Hilfiker, Felipe; Lee, Ben H; Thornton, Joel A; Kurtén, Theo

    2016-02-04

    Iodide-based chemical ionization mass spectrometry (CIMS) has been used to detect and measure concentrations of several atmospherically relevant organic and inorganic compounds. The significant electronegativity of iodide and the strong acidity of hydroiodic acid makes electron transfer and proton abstraction essentially negligible, and the soft nature of the adduct formation ionization technique reduces the chances of sample fragmentation. In addition, iodide has a large negative mass defect, which, when combined with the high resolving power of a high resolution time-of-flight chemical ionization mass spectrometer (HR-ToF-CIMS), provides good selectivity. In this work, we use quantum chemical methods to calculate the binding energies, enthalpies and free energies for clusters of an iodide ion with a number of atmospherically relevant organic and inorganic compounds. Systematic configurational sampling of the free molecules and clusters was carried out at the B3LYP/6-31G* level, followed by subsequent calculations at the PBE/SDD and DLPNO-CCSD(T)/def2-QZVPP//PBE/aug-cc-pVTZ-PP levels. The binding energies, enthalpies, and free energies thus obtained were then compared to the iodide-based University of Washington HR-ToF-CIMS (UW-CIMS) instrument sensitivities for these molecules. We observed a reasonably linear relationship between the cluster binding enthalpies and logarithmic instrument sensitivities already at the PBE/SDD level, which indicates that relatively simple quantum chemical methods can predict the sensitivity of an iodide-based CIMS instrument toward most molecules. However, higher level calculations were needed to treat some outlier molecules, most notably oxalic acid and methylerythritol. Our calculations also corroborated the recent experimental findings that the molecules that the UW-CIMS detects at maximum sensitivity usually have binding enthalpies to iodide which are higher than about 26 kcal/mol, depending slightly on the level of theory.

  12. Centennial annual general meeting of the CIM/CMMI/MIGA. Montreal `98: a vision for the future; Analysis of a particular outburst case in coal mines in Lorraine Basin (France); Analyse d`un cas particulier de surtir dans les mines de charbon dans le basin houiller lorrain (France)

    Energy Technology Data Exchange (ETDEWEB)

    AL Heib, M.; Josien, J.P.; Noirel, J.F. [INERIS (France)

    1998-12-31

    A technique based on core discing to identify the likelihood of an outburst is presented. A guideline has been developed based on the method. A back analysis was undertaken to determine the causes and source location of an outburst in an area surrounding two faults that intersect the yield pillar between gate roads. Numerical modelling was used to estimate the effect of faults on outburst development. The results show that faults cause a change in stress level that can initiate outbursts. The work has been applied to improve methods for the control and prevention of outbursts. 6 refs., 10 figs.

  13. Career information in the mathematical sciences (CIMS). Final report, November 1, 1992--October 31, 1995

    Energy Technology Data Exchange (ETDEWEB)

    Sterrett, A.

    1996-01-29

    This report documents the preparation and distribution of materials designed to aid students is assessing their interests in and prospects for a career in the mathematical sciences. Activities included the preparation of two books, two videos, a world wide web home page, and a workshop meeting on ``Math in Careers`` held at the University of California at Berkeley in January, 1995.

  14. Career Information in the mathematical sciences (CIMS). Technical progress report, November 1, 1992--April 30, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Sterrett, A.

    1993-05-01

    In November of 1992, a CBMS Steering Committee for Career Information was appointed by the CBMS Council. An informal meeting of those members in attendance at the Annual Meeting of the MAA and the AMS was held in January, 1993. The first meeting was held on May 1, 2 in Washington, DC in conjunction with CBMS Council meeting. Information on existing career materials was provided to the Council at that time and Council reactions were obtained. These reactions, along with reviews of material by students, faculty members and counselors, were used by the Steering Committee to plan specific activities for the next 6--18 months. Three initiatives were given high priority: To produce and widely disseminate an annotated bibliography of career information relevant to the mathematical sciences; to remedy the lack of messages to junior high school students, parents, teachers and counselors on the importance of mathematics in finding good jobs in a technological society; and to encourage women and minorities to take all the mathematics that they can and to consider careers in which mathematics plays an important role.

  15. Evaluation of Shipbuilding CAD/CAM/CIM Systems - Phase II (Requirements for Future Systems)

    Science.gov (United States)

    1997-02-01

    Odense Steel Shipyard SENER Ingenieria y Sistemas Peter Marks and Kathleen Riles, Authors of Aligning Technology Torben Andersen, Executive Vice...Sener Ingenieria y Sistemas - FORAN 3 • Intergraph-ISDP ● Black and Veatch - POWRTRAK. The information gleaned from these visits was immense. Perhaps

  16. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Part 1--Teacher. Experimental. Level 3.

    Science.gov (United States)

    Fox, Joan; And Others

    The major goal of the Comprehensive Instructional Management System for mathematics is to provide the classroom teacher in New York City with a well-structured, objective-based curriculum. This first part of the manual for Level 3 includes modules for 14 topics: (1) numbers and numeration; (2) addition of whole numbers; (3) subtraction of whole…

  17. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Workbook Part 2. Experimental. Level 3.

    Science.gov (United States)

    Fox, Joan; And Others

    The activities in this workbook are designed to provide pupils with practice in mastering the performance objectives of the Comprehensive Instructional Management System in mathematics for Level 3, Part 2, in New York City schools. It follows the sequence of the teacher's manual, with the objective number listed on each page. Over 80 performance…

  18. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Part 2--Teacher. Experimental. Level 4.

    Science.gov (United States)

    Fox, Joan; And Others

    The major goal of the Comprehensive Instructional Management System for mathematics is to provide the classroom teacher in New York City with a well-structured, objective-based curriculum. This second part of the manual for Level 4 includes modules for 14 topics: (1) numbers and numeration; (2) addition of whole numbers; (3) subtraction of whole…

  19. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Part 1--Teacher. Experimental. Level 4.

    Science.gov (United States)

    Fox, Joan; And Others

    The major goal of the Comprehensive Instructional Management System for mathematics is to provide the classroom teacher in New York City with a well-structured, objective-based curriculum. This first part of the manual for Level 4 includes modules for 14 topics: (1) numbers and numeration; (2) addition of whole numbers; (3) subtraction of whole…

  20. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Workbook Part 1. Experimental. Level 4.

    Science.gov (United States)

    Fox, Joan; And Others

    The activities in this workbook are designed to provide pupils with practice in mastering the performance objectives of the Comprehensive Instructional Management System in mathematics for Level 4, Part 1, in New York City schools. It follows the sequence of the teacher's manual, with the objective number listed on each page. Over 85 performance…

  1. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Experimental. [Level 1] Answer Key.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    This document is the answer key for level 1 of the teacher-developed mathematics curriculum for New York City Schools. Approximately 220 performance objectives are listed, with reference to the appropriate worksheet for each. The answers are indicated on replicas of the pages in the children's workbooks. (MNS)

  2. CIMS信息集成平台研究%The Research of CIMS Information Integrated Platform

    Institute of Scientific and Technical Information of China (English)

    林蓉

    1999-01-01

    本文首先简要介绍CIMS的概况,接着从信息学角度构筑了对CIMS的更全面认识.在此基础上,通过借鉴吸收己获得有关实践成功的几家企业的CIMS工程实例,提出一种CIMS信息集成平台结构的一般模型,并就此着重讨论了三方面问题.最后提出信息工作者应该也必须在CIMS领域找到自己的立足点和生长点.

  3. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Workbook Part 2. Experimental. Level 4.

    Science.gov (United States)

    Fox, Joan; And Others

    The activities in this workbook are designed to provide pupils with practice in mastering the performance objectives of the Comprehensive Instructional Management System in mathematics for Level 4, Part 2, in New York City schools. It follows the sequence of the teacher's manual, with the objective number listed on each page. Over 80 performance…

  4. 炼油企业CIMS技术探讨%Reserch on CIMS for Refinery

    Institute of Scientific and Technical Information of China (English)

    张光庭

    2001-01-01

    结合炼油企业自身业务及信息流特点,提出炼油企业CIMS集成方案;围绕效益分析,研究CIMS技术的实施;总结CIMS关键技术之一--模型化技术在计划优化中的应用经验.

  5. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Experimental. [Level 6] Answer Key.

    Science.gov (United States)

    Johnson, Dorothy C.; And Others

    This document is the answer key for level 6 of the teacher-developed experimental mathematics curriculum for New York City schools. Approximately 250 performance objectives are listed, with reference to the appropriate worksheet(s) for each. The answers are typed in the appropriate space on each sheet. (YP)

  6. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Workbook Part 1. Experimental. Level 3.

    Science.gov (United States)

    Fox, Joan; And Others

    The activities in this workbook are designed to provide pupils with practice in mastering the performance objectives of the Comprehensive Instructional Management System in mathematics for Level 3, Part 1, in New York City schools. It follows the sequence of the teacher's manual, with the objective number listed on each page. Over 80 performance…

  7. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Part 2--Teacher. Experimental. Level K.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    This is the teacher's manual to accompany part 2 of the workbook for kindergarten pupils in the Comprehensive Instructional Management System, a teacher-designed unified mathematics curriculum for kindergarten through grade 7. It is composed of a curriculum, a testing component, and a computer-managed reporting system. The curriculum is organized…

  8. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Part 2--Teacher. Experimental. Level 3.

    Science.gov (United States)

    Fox, Joan; And Others

    The major goal of the Comprehensive Instructional Management System for mathematics is to provide the classroom teacher in New York City with a well-structured, objective-based curriculum. This second part of the manual for Level 3 includes modules for 14 topics: (1) numbers and numeration; (2) addition of whole numbers; (3) subtraction of whole…

  9. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Workbook Part 1. Experimental. Level 1.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    This document is part 1 of the workbook for grade 1 pupils in the Comprehensive Instructional Management System, a unified mathematics curriculum for kindergarten through grade 7. Each objective is developed by a variety of strategies, with mastery of objectives diagnosed through a testing component. The activities in the student workbook are…

  10. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Part 1--Teacher. Experimental. Level K.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    This is the teacher's manual to accompany part of the workbook for kindergarten pupils in the Comprehensive Instructional Management System, a teacher-designed unified mathematics curriculum for kindergarten through grade 7. It is composed of a curriculum, a testing component, and a computer-managed reporting system. The curriculum is organized…

  11. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Part 1--Teacher. Experimental. Level 2.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    This is the teacher's manual to accompany part 1 of the workbook for grade 2 pupils in the Comprehensive Instructional Management System, a teacher-designed unified mathematics curriculum for kindergarten through grade 7. It is composed of a curriculum, a testing component, and a computer-managed reporting system. The curriculum is organized into…

  12. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Workbook Part 1. Experimental. Level K.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    This document is part 1 of the workbook for kindergarten pupils in the Comprehensive Instructional Management System, a unified mathematics curriculum for kindergarten through grade 7. Each objective is developed by a variety of strategies, with mastery of objectives diagnosed through a testing component. The activities in the student workbook are…

  13. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Part 2--Teacher. Experimental. Level 1.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    This is the teacher's manual to accompany part 2 of the workbook for grade 1 pupils in the Comprehensive Instructional Management System, a teacher-designed unified mathematics curriculum for kindergarten through grade 7. It is composed of a curriculum, a testing component, and a computer-managed reporting system. The curriculum is organized into…

  14. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Workbook Part 2. Experimental. Level 1.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    This document is part 2 of the workbook for grade 1 pupils in the Comprehensive Instructional Management System, a unified mathematics curriculum for kindergarten through grade 7. Each objective is developed by a variety of strategies, with mastery of objectives diagnosed through a testing component. The activities in the student workbook are…

  15. Development of L-histidine immobilized CIM(®) monolithic disks for purification of immunoglobulin G.

    Science.gov (United States)

    Prasanna, Rajasekar R; Kamalanathan, Agamudi S; Vijayalakshmi, Mookambeswaran A

    2015-03-01

    The pseudobiospecific affinity ligand l-histidine was immobilized on epoxy, carbonyldiimidazole (CDI), and ethylenediamine (EDA) convective interaction media (BIA Separations, Slovenia) monolithic disks to obtain the histidyl affinity column for purification of immunoglobulin G (IgG). The kinetics and the mass transfer properties of the affinity columns were studied to determine the optimum buffer condition, flow rate, and concentration of IgG for maximum IgG adsorption. The binding capacities of all the three affinity columns were higher with zwitterionic buffer morpholinopropanesulfonic acid than with charged buffers such as tris-HCl and phosphate buffers, and the optimum pH was 6.5. The interaction of IgG with histidine immobilized CDI and epoxy disks was found to be predominantly driven by ionic interaction, while the interaction with EDA-histidine disk could be partially governed by multiple non-covalent forces of interaction. The maximum binding capacity (Qm ) of l-histidine immobilized on EDA-, CDI-, and epoxy-activated convective interaction media disks were 19.83 ± 0.25, 15.85 ± 0.18 and 12.11 ± 0.17 mg/ml of support, respectively, and the dissociation constant (Kd ) were calculated to be in the micromolar range for all the three histidyl monolithic columns. Purification of IgG from untreated human serum was also attempted, and the results indicate the high potential of this method for purification of total IgG from complex biological sources and also for separation of IgG1 from other subclasses.

  16. Translation and Initial Validation of the Chinese (Cantonese Version of Community Integration Measure for Use in Patients with Chronic Stroke

    Directory of Open Access Journals (Sweden)

    Tai-Wa Liu

    2014-01-01

    Full Text Available Objectives. To (1 translate and culturally adapt the English version Community Integration Measure into Chinese (Cantonese, (2 report the results of initial validation of the Chinese (Cantonese version of CIM (CIM-C including the content validity, internal consistency, test-retest reliability, and factor structure of CIM-C for use in stroke survivors in a Chinese community setting, and (3 investigate the level of community integration of stroke survivors living in Hong Kong. Design. Cross-sectional study. Setting. University-based rehabilitation centre. Participants. 62 (n=62 subjects with chronic stroke. Methods. The CIM-C was produced after forward-backward translation, expert panel review, and pretesting. 25 (n=25 of the same subjects were reassessed after a 1-week interval. Results. The items of the CIM-C demonstrated high internal consistency with a Cronbach’s α of 0.84. The CIM-C showed good test-retest reliability with an intraclass correlation coefficient (ICC of 0.84 (95% confidence interval, 0.64–0.93. A 3-factor structure of the CIM-C including “relationship and engagement,” “sense of knowing,” and “independent living,” was consistent with the original theoretical model. Hong Kong stroke survivors revealed a high level of community integration as measured by the CIM-C (mean (SD: 43.48 (5.79. Conclusions. The CIM-C is a valid and reliable measure for clinical use.

  17. Observation and modelling of HOx radicals in a boreal forest

    Directory of Open Access Journals (Sweden)

    K. Hens

    2014-08-01

    Full Text Available Measurements of OH and HO2 radicals were conducted in a pine-dominated forest in southern Finland during the HUMPPA-COPEC-2010 (Hyytiälä United Measurements of Photochemistry and Particles in Air – Comprehensive Organic Precursor Emission and Concentration study field campaign in summer 2010. Simultaneous side-by-side measurements of hydroxyl radicals were conducted with two instruments using chemical ionization mass spectrometry (CIMS and laser-induced fluorescence (LIF, indicating small systematic disagreement, OHLIF / OHCIMS = (1.31 ± 0.14. Subsequently, the LIF instrument was moved to the top of a 20 m tower, just above the canopy, to investigate the radical chemistry at the ecosystem–atmosphere interface. Comprehensive measurements including observations of many volatile organic compounds (VOCs and the total OH reactivity were conducted and analysed using steady-state calculations as well as an observationally constrained box model. Production rates of OH calculated from measured OH precursors are consistent with those derived from the steady-state assumption and measured total OH loss under conditions of moderate OH reactivity. The primary photolytic sources of OH contribute up to one-third to the total OH production. OH recycling, which occurs mainly by HO2 reacting with NO and O3, dominates the total hydroxyl radical production in this boreal forest. Box model simulations agree with measurements for hydroxyl radicals (OHmod. / OHobs. = 1.00 ± 0.16, while HO2 mixing ratios are significantly under-predicted (HO2mod. / HO2obs. = 0.3 ± 0.2, and simulated OH reactivity does not match the observed OH reactivity. The simultaneous under-prediction of HO2 and OH reactivity in periods in which OH concentrations were simulated realistically suggests that the missing OH reactivity is an unaccounted-for source of HO2. Detailed analysis of the HOx production, loss, and recycling pathways suggests that in periods of high total OH reactivity

  18. Design and application of a technologically explicit hybrid energy-economy policy model with micro and macro economic dynamics

    Science.gov (United States)

    Bataille, Christopher G. F.

    2005-11-01

    Are further energy efficiency gains, or more recently greenhouse gas reductions, expensive or cheap? Analysts provide conflicting advice to policy makers based on divergent modelling perspectives, a 'top-down/bottom-up debate' in which economists use equation based models that equilibrate markets by maximizing consumer welfare, and technologists use technology simulation models that minimize the financial cost of providing energy services. This thesis summarizes a long term research project to find a middle ground between these two positions that is more useful to policy makers. Starting with the individual components of a behaviourally realistic and technologically explicit simulation model (ISTUM---Inter Sectoral Technology Use Model), or "hybrid", the individual sectors of the economy are linked using a framework of micro and macro economic feedbacks. These feedbacks are taken from the economic theory that informs the computable general equilibrium (CGE) family of models. Speaking in the languages of both economists and engineers, the resulting "physical" equilibrium model of Canada (CIMS---Canadian Integrated Modeling System), equilibrates energy and end-product markets, including imports and exports, for seven regions and 15 economic sectors, including primary industry, manufacturing, transportation, commerce, residences, governmental infrastructure and the energy supply sectors. Several different policy experiments demonstrate the value-added of the model and how its results compare to top-down and bottom-up practice. In general, the results show that technical adjustments make up about half the response to simulated energy policy, and macroeconomic demand adjustments the other half. Induced technical adjustments predominate with minor policies, while the importance of macroeconomic demand adjustment increases with the strength of the policy. Results are also shown for an experiment to derive estimates of future elasticity of substitution (ESUB) and

  19. Establishing an Appropriate Level of Detail (LoD) for a Building Information Model (BIM) - West Block, Parliament Hill, Ottawa, Canada

    Science.gov (United States)

    Fai, S.; Rafeiro, J.

    2014-05-01

    In 2011, Public Works and Government Services Canada (PWGSC) embarked on a comprehensive rehabilitation of the historically significant West Block of Canada's Parliament Hill. With over 17 thousand square meters of floor space, the West Block is one of the largest projects of its kind in the world. As part of the rehabilitation, PWGSC is working with the Carleton Immersive Media Studio (CIMS) to develop a building information model (BIM) that can serve as maintenance and life-cycle management tool once construction is completed. The scale and complexity of the model have presented many challenges. One of these challenges is determining appropriate levels of detail (LoD). While still a matter of debate in the development of international BIM standards, LoD is further complicated in the context of heritage buildings because we must reconcile the LoD of the BIM with that used in the documentation process (terrestrial laser scan and photogrammetric survey data). In this paper, we will discuss our work to date on establishing appropriate LoD within the West Block BIM that will best serve the end use. To facilitate this, we have developed a single parametric model for gothic pointed arches that can be used for over seventy-five unique window types present in the West Block. Using the AEC (CAN) BIM as a reference, we have developed a workflow to test each of these window types at three distinct levels of detail. We have found that the parametric Gothic arch significantly reduces the amount of time necessary to develop scenarios to test appropriate LoD.

  20. 多维度电网模型一体化存储与管理技术%Integrated Storage and Management Technology for Multi-dimensional Grid Model

    Institute of Scientific and Technical Information of China (English)

    闫湖; 李立新; 袁荣昌; 林静怀; 江凡; 谢巧云

    2014-01-01

    智能调度要求完整、一致、准确、及时、可靠的电网模型数据支持。文中提出了一种多维度电网模型一体化存储与管理方法,以满足“横向集成、纵向贯通”和调度中心基于全电网模型的分析、计算以及智能调度等新型业务需要。该方法基于版本化分布式数据库建立了一体化存储与管理机制,将不同历史版本、不同地区、不同应用 CIM/E 格式电网模型数据统一存储于分布式数据库中。文中所提出的方法不但可以在时间维度上进行电网模型可追溯管理、在空间维度上实现各地区与全网模型统一存储,而且可以满足公共信息模型和私有应用模型存储与管理需求,此外,电网模型在分布式数据库中以增量方式存储,大大减少了冗余数据。%Intelligent scheduling requires support of complete,consistent,accurate,timely and reliable grid model data.This paper presents a method for integrated storage and management of multi-dimensional grid model to meet the “horizontal integration,vertical penetration"requirement and new-type business needs of the dispatch center based on the whole grid model such as analysis,computing,intelligent scheduling,etc.Based on visual,distributed database,an integrated storage and management mechanism is designed,with different historical versions,different regions,different applications CIM/E format grid model data all stored in a distributed database.The proposed method can not only have the grid model traced in time dimension,but also in spatial dimension various regions and the whole grid model can be stored together.Meanwhile,it can meet storage and management needs of the common information grid model and application grid model as well as the grid model distributed database storage incrementally,greatly reducing redundant data.

  1. Evaluation of the modified carbapenem inactivation method and sodium mercaptoacetate-combination method for the detection of metallo-β-lactamase production by carbapenemase-producing Enterobacteriaceae.

    Science.gov (United States)

    Yamada, Kageto; Kashiwa, Machiko; Arai, Katsumi; Nagano, Noriyuki; Saito, Ryoichi

    2017-01-01

    We evaluated the effectiveness of carbapenem inactivation method (CIM) and modified CIM (mCIM). Our results indicated that mCIM with 4h incubation improved sensitivity and specificity for detecting carbapenemase-producing Enterobacteriaceae compared to CIM. Additionally, we developed a sodium mercaptoacetate-combination method (SMA-mCIM) to detect metallo-β-lactamase (MBL) with high sensitivity and specificity.

  2. Aiemtuzumab used for induction therapy in cynomolgus model%人源化CD52单克隆抗体诱导食蟹猴动物模型的建立

    Institute of Scientific and Technical Information of China (English)

    单廷; 张景斌; 曲林林; 李秋荣; 李宁; 黎介寿

    2011-01-01

    Objective: To establish the model of alemtuzumab used for induction therapy in cynomolgus monkey. Methods: Monkeys without CD52 antigen on erythrocytes were selected and lymphocyte depletion and repopulation in peripheral blood was documented. Results: Powerful depletion of lymphocytes from blood followed by gradual repopulation was observed. CD20 + B cells, CD8 + T cells,CIM + T cells returned to pretreatment levels by day 21, 35, 56. Conclusion: Depletion of lymphocytes in peripheral blood was less powerful and repopulation occurred faster than in patients. This model can be used in preclinical transplantation.%目的:建立人源化CD52单克隆抗体诱导食蟹猴的动物模型.方法:使用流式细胞仪筛选出红细胞表面不表达CD52抗原的食蟹猴,并观察给药后不同时间血中淋巴细胞数量变化情况.结果:食蟹猴血中淋巴细胞呈现出快速被清除及恢复的过程.CD20+B淋巴细胞、CD8+T淋巴细胞、CD4+T淋巴细胞分别在给药后21、35和56 d恢复至给药前水平.结论:食蟹猴外周血中淋巴细胞清除效果略低于临床病人,恢复速度较快.本实验模型可用于临床人源化CD52单克隆抗体器官移植前的实验研究.

  3. Modeling chemistry in and above snow at Summit, Greenland − Part 2: Impact of snowpack chemistry on the oxidation capacity of the boundary layer

    Directory of Open Access Journals (Sweden)

    B. Lefer

    2012-02-01

    Full Text Available The chemical composition of the boundary layer in snow covered regions is impacted by chemistry in the snowpack via uptake, processing, and emission of atmospheric trace gases. We use the coupled one-dimensional (1-D snow chemistry and atmospheric boundary layer model MISTRA-SNOW to study the impact of snowpack chemistry on the oxidation capacity of the boundary layer. The model includes gas phase photochemistry and chemical reactions both in the interstitial air and the atmosphere. Chemistry on snow grains is simulated assuming a liquid-like layer (LLL, treated as an aqueous layer on the snow grain surface. The model has been recently compared with BrO and NO data taken on 10 June–13 June 2008 as part of the Greenland Summit Halogen-HOx experiment (GSHOX. In the present study, we use the same focus period to investigate the influence of snowpack derived chemistry on OH and HOx + RO2 in the boundary layer. We compare model results with chemical ionization mass spectrometry (CIMS measurements of the hydroxyl radical (OH and of the hydroperoxyl radical (HO2 plus the sum of all organic peroxy radicals (RO2 taken at Summit during summer 2008. Using sensitivity runs we show that snowpack influenced nitrogen cycling and bromine chemistry both increase the oxidation capacity of the boundary layer and that together they increase the mid-day OH concentrations by approximately a factor of 2. We show for the first time, using an unconstrained coupled one-dimensional snowpack-boundary layer model, that air-snow interactions impact the oxidation capacity of the boundary layer and that it is not possible to match measured OH levels without snowpack NOx and halogen emissions. Model predicted HONO compared with mistchamber measurements suggests there may be an unknown HONO source at Summit. Other model predicted HOx precursors, H2O2 and HCHO, compare well with measurements taken in summer 2000. Over 3 days, snow sourced NOx contributes an additional 2 ppb to

  4. Alternativa terapeutica en la isquemia cerebral empleando la Eritropoyetina humana recombinante (rHu-EPO CIM) como neuroprotector.

    OpenAIRE

    Iliana Sosa Testé; Jorge D. García Salman; Nelvys Subirós; Consuelo González; Yamila Rodríguez; Julio C. García Rodríguez

    2005-01-01

    Las enfermedades vasculares constituyen las terceras causas de muerte en Cuba. Su variante isquémica es causa de invalidez y perdida de la calidad de la vida. La búsqueda de agentes neuroprotectores es muy importante sí tenemos en cuenta que nuestra población está envejecida. Muchos son las razones por la que una molécula con propiedades neuroprotectoras en los modelos animales no tenga los resultados en ensayos clínicos en humanos. Este trabajo analiza y discute como mejorar estos aspectos. ...

  5. Evolución de un sistema de manufactura flexible (FMS) a un sistema de manufactura integrada por computador (CIM)

    OpenAIRE

    Fúquene Retamoso, Carlos Eduardo; Pontificia Universidad Javeriana; Aguirre Mayorga, Hugo Santiago; Pontificia Universidad Javeriana; Córdoba Pinzón, Nazly Bibiana; Pontificia Universidad Javeriana

    2010-01-01

    el desarrollo de las máquinas herramientas, los elementos del control de la producción, los robots, computadores y las redes de comunicación han transformado los medios de manufactura existentes en sistemas de manufactura integrados y versátiles. Aquellas industrias que deseen mantenerse competitivamente en la era de la información y la globalización actual están obligadas a introducir tecnologías avanzadas de producción, orientadas a sistemas de manufactura flexible capaces de manejar los pr...

  6. CIMS Technology and Knowledge Innovation in Enterprises%CIMS技术与企业知识创新

    Institute of Scientific and Technical Information of China (English)

    周旭东

    2002-01-01

    CIMS技术改变了传统制造业的运作模式.提出了CIMS环境下全新的思维和生产方式.CIMS技术有助于企业知识创新,并且大大提高企业在市场经济环境下的竞争能力.

  7. Proceedings of the 10. CIM maintenance/engineering conference and technical program: Maintenance engineering 2000 and beyond

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-31

    Proceedings of the conference, encompassing some 40 presentations, are contained on this CD-ROM. The presentations dealt with the technology impacts on the mining industry in Canada, with emphasis on maintenance. Electrical equipment, underground equipment, hoisting and surface equipment, materials and electric power, and new trends in maintenance management are featured.

  8. Muscle wasting and the temporal gene expression pattern in a novel rat intensive care unit model

    Directory of Open Access Journals (Sweden)

    Llano-Diez Monica

    2011-12-01

    Full Text Available Abstract Background Acute quadriplegic myopathy (AQM or critical illness myopathy (CIM is frequently observed in intensive care unit (ICU patients. To elucidate duration-dependent effects of the ICU intervention on molecular and functional networks that control the muscle wasting and weakness associated with AQM, a gene expression profile was analyzed at time points varying from 6 hours to 14 days in a unique experimental rat model mimicking ICU conditions, i.e., post-synaptically paralyzed, mechanically ventilated and extensively monitored animals. Results During the observation period, 1583 genes were significantly up- or down-regulated by factors of two or greater. A significant temporal gene expression pattern was constructed at short (6 h-4 days, intermediate (5-8 days and long (9-14 days durations. A striking early and maintained up-regulation (6 h-14d of muscle atrogenes (muscle ring-finger 1/tripartite motif-containing 63 and F-box protein 32/atrogin-1 was observed, followed by an up-regulation of the proteolytic systems at intermediate and long durations (5-14d. Oxidative stress response genes and genes that take part in amino acid catabolism, cell cycle arrest, apoptosis, muscle development, and protein synthesis together with myogenic factors were significantly up-regulated from 5 to 14 days. At 9-14 d, genes involved in immune response and the caspase cascade were up-regulated. At 5-14d, genes related to contractile (myosin heavy chain and myosin binding protein C, regulatory (troponin, tropomyosin, developmental, caveolin-3, extracellular matrix, glycolysis/gluconeogenesis, cytoskeleton/sarcomere regulation and mitochondrial proteins were down-regulated. An activation of genes related to muscle growth and new muscle fiber formation (increase of myogenic factors and JunB and down-regulation of myostatin and up-regulation of genes that code protein synthesis and translation factors were found from 5 to 14 days. Conclusions Novel

  9. Model Transformations? Transformation Models!

    NARCIS (Netherlands)

    Bézivin, J.; Büttner, F.; Gogolla, M.; Jouault, F.; Kurtev, I.; Lindow, A.

    2006-01-01

    Much of the current work on model transformations seems essentially operational and executable in nature. Executable descriptions are necessary from the point of view of implementation. But from a conceptual point of view, transformations can also be viewed as descriptive models by stating only the

  10. Estimated Probabililty of Chest Injury During an International Space Station Mission

    Science.gov (United States)

    Lewandowski, Beth E.; Milo, Eric A.; Brooker, John E.; Weaver, Aaron S.; Myers, Jerry G., Jr.

    2013-01-01

    The Integrated Medical Model (IMM) is a decision support tool that is useful to spaceflight mission planners and medical system designers when assessing risks and optimizing medical systems. The IMM project maintains a database of medical conditions that could occur during a spaceflight. The IMM project is in the process of assigning an incidence rate, the associated functional impairment, and a best and a worst case end state for each condition. The purpose of this work was to develop the IMM Chest Injury Module (CIM). The CIM calculates the incidence rate of chest injury per person-year of spaceflight on the International Space Station (ISS). The CIM was built so that the probability of chest injury during one year on ISS could be predicted. These results will be incorporated into the IMM Chest Injury Clinical Finding Form and used within the parent IMM model.

  11. Modelling SDL, Modelling Languages

    Directory of Open Access Journals (Sweden)

    Michael Piefel

    2007-02-01

    Full Text Available Today's software systems are too complex to implement them and model them using only one language. As a result, modern software engineering uses different languages for different levels of abstraction and different system aspects. Thus to handle an increasing number of related or integrated languages is the most challenging task in the development of tools. We use object oriented metamodelling to describe languages. Object orientation allows us to derive abstract reusable concept definitions (concept classes from existing languages. This language definition technique concentrates on semantic abstractions rather than syntactical peculiarities. We present a set of common concept classes that describe structure, behaviour, and data aspects of high-level modelling languages. Our models contain syntax modelling using the OMG MOF as well as static semantic constraints written in OMG OCL. We derive metamodels for subsets of SDL and UML from these common concepts, and we show for parts of these languages that they can be modelled and related to each other through the same abstract concepts.

  12. Actant Models

    DEFF Research Database (Denmark)

    Poulsen, Helle

    1996-01-01

    This paper presents a functional modelling method called Actant Modelling rooted in linguistics and semiotics. Actant modelling can be integrated with Multilevel Flow Modelling (MFM) in order to give an interpretation of actants.......This paper presents a functional modelling method called Actant Modelling rooted in linguistics and semiotics. Actant modelling can be integrated with Multilevel Flow Modelling (MFM) in order to give an interpretation of actants....

  13. Modelling the models

    CERN Multimedia

    Anaïs Schaeffer

    2012-01-01

    By analysing the production of mesons in the forward region of LHC proton-proton collisions, the LHCf collaboration has provided key information needed to calibrate extremely high-energy cosmic ray models.   Average transverse momentum (pT) as a function of rapidity loss ∆y. Black dots represent LHCf data and the red diamonds represent SPS experiment UA7 results. The predictions of hadronic interaction models are shown by open boxes (sibyll 2.1), open circles (qgsjet II-03) and open triangles (epos 1.99). Among these models, epos 1.99 shows the best overall agreement with the LHCf data. LHCf is dedicated to the measurement of neutral particles emitted at extremely small angles in the very forward region of LHC collisions. Two imaging calorimeters – Arm1 and Arm2 – take data 140 m either side of the ATLAS interaction point. “The physics goal of this type of analysis is to provide data for calibrating the hadron interaction models – the well-known &...

  14. IDENTIFICATION OF HARMONIC SOURCES IN DEREGULATED POWER SECTOR

    Directory of Open Access Journals (Sweden)

    KRITI VAID,

    2011-03-01

    Full Text Available In this paper identification of origin of harmonic source in deregulated power sector has been carried out. Critical impedance method (CIM for detection of harmonic disturbances caused between utility and source side has already been reported in literature. The method is based on direction of reactive power flow in the power system when there is the presence of harmonic load. Taking the CIM as the base method harmonic sources are identified in deregulated power sector. Due to unavailability of practical data simulation approach has been adopted. A five bus system model with two Generation ompanies (GENCOS has been simulated for power transfer from GENCO to the considered five bus system. Harmonic current is injected into the system by using a three phase diode rectifier. The results obtainedusing the CIM clearly identifies whether the harmonic source is present in GENCO side or the load side.

  15. Promoting Models

    Science.gov (United States)

    Li, Qin; Zhao, Yongxin; Wu, Xiaofeng; Liu, Si

    There can be multitudinous models specifying aspects of the same system. Each model has a bias towards one aspect. These models often override in specific aspects though they have different expressions. A specification written in one model can be refined by introducing additional information from other models. The paper proposes a concept of promoting models which is a methodology to obtain refinements with support from cooperating models. It refines a primary model by integrating the information from a secondary model. The promotion principle is not merely an academic point, but also a reliable and robust engineering technique which can be used to develop software and hardware systems. It can also check the consistency between two specifications from different models. A case of modeling a simple online shopping system with the cooperation of the guarded design model and CSP model illustrates the practicability of the promotion principle.

  16. Modelling Practice

    DEFF Research Database (Denmark)

    2011-01-01

    requirements; model construction; model solution; model verification; model validation and finally model deployment and maintenance. Within the adopted methodology, each step is discussedthrough the consideration of key issues and questions relevant to the modelling activity. Practical advice, based on many......’ activity, under constraints of system insight, time, cost and human resources. The George Box dictum that “all models are wrong, some are useful” should be coupled with the parsimony principle to ensure optimal outcomes.......This chapter deals with the practicalities of building, testing, deploying and maintaining models. It gives specific advice for each phase of the modelling cycle. To do this, a modelling framework is introduced which covers: problem and model definition; model conceptualization; model data...

  17. A Systems Engineering Process for Development of Federated Simulations

    Science.gov (United States)

    2009-01-01

    com- mon definition of requirements via the Military Missions and Means framework [4]. It then goes on to call for further pro- cess of information...by the Military Missions and Means Framework (MMF) Computer Independent Model (CIM) Operational Idea, high-level view Platform Independent Model

  18. Patient-Provider Interactions Affect Symptoms in Gastroesophageal Reflux Disease: A Pilot Randomized, Double-Blind, Placebo-Controlled Trial.

    Directory of Open Access Journals (Sweden)

    Michelle L Dossett

    Full Text Available It is unclear whether the benefits that some patients derive from complementary and integrative medicine (CIM are related to the therapies recommended or to the consultation process as some CIM provider visits are more involved than conventional medical visits. Many patients with gastrointestinal conditions seek out CIM therapies, and prior work has demonstrated that the quality of the patient-provider interaction can improve health outcomes in irritable bowel syndrome, however, the impact of this interaction on gastroesophageal reflux disease (GERD is unknown. We aimed to assess the safety and feasibility of conducting a 2 x 2 factorial design study preliminarily exploring the impact of the patient-provider interaction, and the effect of an over-the-counter homeopathic product, Acidil, on symptoms and health-related quality of life in subjects with GERD.24 subjects with GERD-related symptoms were randomized in a 2 x 2 factorial design to receive 1 either a standard visit based on an empathic conventional primary care evaluation or an expanded visit with questions modeled after a CIM consultation and 2 either Acidil or placebo for two weeks. Subjects completed a daily GERD symptom diary and additional measures of symptom severity and health-related quality of life.There was no significant difference in GERD symptom severity between the Acidil and placebo groups from baseline to follow-up (p = 0.41, however, subjects who received the expanded visit were significantly more likely to report a 50% or greater improvement in symptom severity compared to subjects who received the standard visit (p = 0.01. Total consultation length, perceived empathy, and baseline beliefs in CIM were not associated with treatment outcomes.An expanded patient-provider visit resulted in greater GERD symptom improvement than a standard empathic medical visit. CIM consultations may have enhanced placebo effects, and further studies to assess the active components of this

  19. Model Warehouse

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    This paper puts forward a new conception:model warehouse,analyzes the reason why model warehouse appears and introduces the characteristics and architecture of model warehouse.Last,this paper points out that model warehouse is an important part of WebGIS.

  20. Model theory

    CERN Document Server

    Chang, CC

    2012-01-01

    Model theory deals with a branch of mathematical logic showing connections between a formal language and its interpretations or models. This is the first and most successful textbook in logical model theory. Extensively updated and corrected in 1990 to accommodate developments in model theoretic methods - including classification theory and nonstandard analysis - the third edition added entirely new sections, exercises, and references. Each chapter introduces an individual method and discusses specific applications. Basic methods of constructing models include constants, elementary chains, Sko

  1. Model cities

    OpenAIRE

    Batty, M.

    2007-01-01

    The term ?model? is now central to our thinking about how weunderstand and design cities. We suggest a variety of ways inwhich we use ?models?, linking these ideas to Abercrombie?sexposition of Town and Country Planning which represented thestate of the art fifty years ago. Here we focus on using models asphysical representations of the city, tracing the development ofsymbolic models where the focus is on simulating how functiongenerates form, to iconic models where the focus is on representi...

  2. Event Modeling

    DEFF Research Database (Denmark)

    Bækgaard, Lars

    2001-01-01

    The purpose of this chapter is to discuss conceptual event modeling within a context of information modeling. Traditionally, information modeling has been concerned with the modeling of a universe of discourse in terms of information structures. However, most interesting universes of discourse...... are dynamic and we present a modeling approach that can be used to model such dynamics. We characterize events as both information objects and change agents (Bækgaard 1997). When viewed as information objects events are phenomena that can be observed and described. For example, borrow events in a library can...

  3. Event Modeling

    DEFF Research Database (Denmark)

    Bækgaard, Lars

    2001-01-01

    The purpose of this chapter is to discuss conceptual event modeling within a context of information modeling. Traditionally, information modeling has been concerned with the modeling of a universe of discourse in terms of information structures. However, most interesting universes of discourse...... are dynamic and we present a modeling approach that can be used to model such dynamics.We characterize events as both information objects and change agents (Bækgaard 1997). When viewed as information objects events are phenomena that can be observed and described. For example, borrow events in a library can...

  4. Computable models

    CERN Document Server

    Turner, Raymond

    2009-01-01

    Computational models can be found everywhere in present day science and engineering. In providing a logical framework and foundation for the specification and design of specification languages, Raymond Turner uses this framework to introduce and study computable models. In doing so he presents the first systematic attempt to provide computational models with a logical foundation. Computable models have wide-ranging applications from programming language semantics and specification languages, through to knowledge representation languages and formalism for natural language semantics. They are al

  5. Zeebrugge Model

    DEFF Research Database (Denmark)

    Sclütter, Flemming; Frigaard, Peter; Liu, Zhou

    This report presents the model test results on wave run-up on the Zeebrugge breakwater under the simulated prototype storms. The model test was performed in January 2000 at the Hydraulics & Coastal Engineering Laboratory, Aalborg University. The detailed description of the model is given...

  6. Constitutive Models

    DEFF Research Database (Denmark)

    2011-01-01

    This chapter presents various types of constitutive models and their applications. There are 3 aspects dealt with in this chapter, namely: creation and solution of property models, the application of parameter estimation and finally application examples of constitutive models. A systematic...

  7. Model Experiments and Model Descriptions

    Science.gov (United States)

    Jackman, Charles H.; Ko, Malcolm K. W.; Weisenstein, Debra; Scott, Courtney J.; Shia, Run-Lie; Rodriguez, Jose; Sze, N. D.; Vohralik, Peter; Randeniya, Lakshman; Plumb, Ian

    1999-01-01

    The Second Workshop on Stratospheric Models and Measurements Workshop (M&M II) is the continuation of the effort previously started in the first Workshop (M&M I, Prather and Remsberg [1993]) held in 1992. As originally stated, the aim of M&M is to provide a foundation for establishing the credibility of stratospheric models used in environmental assessments of the ozone response to chlorofluorocarbons, aircraft emissions, and other climate-chemistry interactions. To accomplish this, a set of measurements of the present day atmosphere was selected. The intent was that successful simulations of the set of measurements should become the prerequisite for the acceptance of these models as having a reliable prediction for future ozone behavior. This section is divided into two: model experiment and model descriptions. In the model experiment, participant were given the charge to design a number of experiments that would use observations to test whether models are using the correct mechanisms to simulate the distributions of ozone and other trace gases in the atmosphere. The purpose is closely tied to the needs to reduce the uncertainties in the model predicted responses of stratospheric ozone to perturbations. The specifications for the experiments were sent out to the modeling community in June 1997. Twenty eight modeling groups responded to the requests for input. The first part of this section discusses the different modeling group, along with the experiments performed. Part two of this section, gives brief descriptions of each model as provided by the individual modeling groups.

  8. Mapping small-effect and linked quantitative trait loci for complex traits in backcross or DH populations via a multi-locus GWAS methodology.

    Science.gov (United States)

    Wang, Shi-Bo; Wen, Yang-Jun; Ren, Wen-Long; Ni, Yuan-Li; Zhang, Jin; Feng, Jian-Ying; Zhang, Yuan-Ming

    2016-01-01

    Composite interval mapping (CIM) is the most widely-used method in linkage analysis. Its main feature is the ability to control genomic background effects via inclusion of co-factors in its genetic model. However, the result often depends on how the co-factors are selected, especially for small-effect and linked quantitative trait loci (QTL). To address this issue, here we proposed a new method under the framework of genome-wide association studies (GWAS). First, a single-locus random-SNP-effect mixed linear model method for GWAS was used to scan each putative QTL on the genome in backcross or doubled haploid populations. Here, controlling background via selecting markers in the CIM was replaced by estimating polygenic variance. Then, all the peaks in the negative logarithm P-value curve were selected as the positions of multiple putative QTL to be included in a multi-locus genetic model, and true QTL were automatically identified by empirical Bayes. This called genome-wide CIM (GCIM). A series of simulated and real datasets was used to validate the new method. As a result, the new method had higher power in QTL detection, greater accuracy in QTL effect estimation, and stronger robustness under various backgrounds as compared with the CIM and empirical Bayes methods.

  9. Scalable Models Using Model Transformation

    Science.gov (United States)

    2008-07-13

    and the following companies: Agilent, Bosch, HSBC , Lockheed-Martin, National Instruments, and Toyota. Scalable Models Using Model Transformation...parametrization, and workflow automation. (AFRL), the State of California Micro Program, and the following companies: Agi- lent, Bosch, HSBC , Lockheed

  10. Cadastral Modeling

    DEFF Research Database (Denmark)

    Stubkjær, Erik

    2005-01-01

    to the modeling of an industrial sector, as it aims at rendering the basic concepts that relate to the domain of real estate and the pertinent human activities. The palpable objects are pieces of land and buildings, documents, data stores and archives, as well as persons in their diverse roles as owners, holders...... to land. The paper advances the position that cadastral modeling has to include not only the physical objects, agents, and information sets of the domain, but also the objectives or requirements of cadastral systems.......Modeling is a term that refers to a variety of efforts, including data and process modeling. The domain to be modeled may be a department, an organization, or even an industrial sector. E-business presupposes the modeling of an industrial sector, a substantial task. Cadastral modeling compares...

  11. Climate Models

    Science.gov (United States)

    Druyan, Leonard M.

    2012-01-01

    Climate models is a very broad topic, so a single volume can only offer a small sampling of relevant research activities. This volume of 14 chapters includes descriptions of a variety of modeling studies for a variety of geographic regions by an international roster of authors. The climate research community generally uses the rubric climate models to refer to organized sets of computer instructions that produce simulations of climate evolution. The code is based on physical relationships that describe the shared variability of meteorological parameters such as temperature, humidity, precipitation rate, circulation, radiation fluxes, etc. Three-dimensional climate models are integrated over time in order to compute the temporal and spatial variations of these parameters. Model domains can be global or regional and the horizontal and vertical resolutions of the computational grid vary from model to model. Considering the entire climate system requires accounting for interactions between solar insolation, atmospheric, oceanic and continental processes, the latter including land hydrology and vegetation. Model simulations may concentrate on one or more of these components, but the most sophisticated models will estimate the mutual interactions of all of these environments. Advances in computer technology have prompted investments in more complex model configurations that consider more phenomena interactions than were possible with yesterday s computers. However, not every attempt to add to the computational layers is rewarded by better model performance. Extensive research is required to test and document any advantages gained by greater sophistication in model formulation. One purpose for publishing climate model research results is to present purported advances for evaluation by the scientific community.

  12. Mathematical modelling

    CERN Document Server

    2016-01-01

    This book provides a thorough introduction to the challenge of applying mathematics in real-world scenarios. Modelling tasks rarely involve well-defined categories, and they often require multidisciplinary input from mathematics, physics, computer sciences, or engineering. In keeping with this spirit of modelling, the book includes a wealth of cross-references between the chapters and frequently points to the real-world context. The book combines classical approaches to modelling with novel areas such as soft computing methods, inverse problems, and model uncertainty. Attention is also paid to the interaction between models, data and the use of mathematical software. The reader will find a broad selection of theoretical tools for practicing industrial mathematics, including the analysis of continuum models, probabilistic and discrete phenomena, and asymptotic and sensitivity analysis.

  13. Turbulence Model

    DEFF Research Database (Denmark)

    Nielsen, Mogens Peter; Shui, Wan; Johansson, Jens

    2011-01-01

    In this report a new turbulence model is presented.In contrast to the bulk of modern work, the model is a classical continuum model with a relatively simple constitutive equation. The constitutive equation is, as usual in continuum mechanics, entirely empirical. It has the usual Newton or Stokes...... term with stresses depending linearly on the strain rates. This term takes into account the transfer of linear momentum from one part of the fluid to another. Besides there is another term, which takes into account the transfer of angular momentum. Thus the model implies a new definition of turbulence....... The model is in a virgin state, but a number of numerical tests have been carried out with good results. It is published to encourage other researchers to study the model in order to find its merits and possible limitations....

  14. Mathematical modelling

    DEFF Research Database (Denmark)

    Blomhøj, Morten

    2004-01-01

    Developing competences for setting up, analysing and criticising mathematical models are normally seen as relevant only from and above upper secondary level. The general belief among teachers is that modelling activities presuppose conceptual understanding of the mathematics involved. Mathematical...... modelling, however, can be seen as a practice of teaching that place the relation between real life and mathematics into the centre of teaching and learning mathematics, and this is relevant at all levels. Modelling activities may motivate the learning process and help the learner to establish cognitive...... roots for the construction of important mathematical concepts. In addition competences for setting up, analysing and criticising modelling processes and the possible use of models is a formative aim in this own right for mathematics teaching in general education. The paper presents a theoretical...

  15. Spherical models

    CERN Document Server

    Wenninger, Magnus J

    2012-01-01

    Well-illustrated, practical approach to creating star-faced spherical forms that can serve as basic structures for geodesic domes. Complete instructions for making models from circular bands of paper with just a ruler and compass. Discusses tessellation, or tiling, and how to make spherical models of the semiregular solids and concludes with a discussion of the relationship of polyhedra to geodesic domes and directions for building models of domes. "". . . very pleasant reading."" - Science. 1979 edition.

  16. Zeebrugge Model

    DEFF Research Database (Denmark)

    Liu, Zhou; Frigaard, Peter

    This report presents the model on wave run-up and run-down on the Zeebrugge breakwater under short-crested oblique wave attacks. The model test was performed in March-April 2000 at the Hydraulics & Coastal Engineering Laboratory, Aalborg University.......This report presents the model on wave run-up and run-down on the Zeebrugge breakwater under short-crested oblique wave attacks. The model test was performed in March-April 2000 at the Hydraulics & Coastal Engineering Laboratory, Aalborg University....

  17. Ventilation Model

    Energy Technology Data Exchange (ETDEWEB)

    V. Chipman

    2002-10-05

    The purpose of the Ventilation Model is to simulate the heat transfer processes in and around waste emplacement drifts during periods of forced ventilation. The model evaluates the effects of emplacement drift ventilation on the thermal conditions in the emplacement drifts and surrounding rock mass, and calculates the heat removal by ventilation as a measure of the viability of ventilation to delay the onset of peak repository temperature and reduce its magnitude. The heat removal by ventilation is temporally and spatially dependent, and is expressed as the fraction of heat carried away by the ventilation air compared to the fraction of heat produced by radionuclide decay. One minus the heat removal is called the wall heat fraction, or the remaining amount of heat that is transferred via conduction to the surrounding rock mass. Downstream models, such as the ''Multiscale Thermohydrologic Model'' (BSC 2001), use the wall heat fractions as outputted from the Ventilation Model to initialize their post-closure analyses. The Ventilation Model report was initially developed to analyze the effects of preclosure continuous ventilation in the Engineered Barrier System (EBS) emplacement drifts, and to provide heat removal data to support EBS design. Revision 00 of the Ventilation Model included documentation of the modeling results from the ANSYS-based heat transfer model. The purposes of Revision 01 of the Ventilation Model are: (1) To validate the conceptual model for preclosure ventilation of emplacement drifts and verify its numerical application in accordance with new procedural requirements as outlined in AP-SIII-10Q, Models (Section 7.0). (2) To satisfy technical issues posed in KTI agreement RDTME 3.14 (Reamer and Williams 2001a). Specifically to demonstrate, with respect to the ANSYS ventilation model, the adequacy of the discretization (Section 6.2.3.1), and the downstream applicability of the model results (i.e. wall heat fractions) to

  18. Modeling Documents with Event Model

    Directory of Open Access Journals (Sweden)

    Longhui Wang

    2015-08-01

    Full Text Available Currently deep learning has made great breakthroughs in visual and speech processing, mainly because it draws lessons from the hierarchical mode that brain deals with images and speech. In the field of NLP, a topic model is one of the important ways for modeling documents. Topic models are built on a generative model that clearly does not match the way humans write. In this paper, we propose Event Model, which is unsupervised and based on the language processing mechanism of neurolinguistics, to model documents. In Event Model, documents are descriptions of concrete or abstract events seen, heard, or sensed by people and words are objects in the events. Event Model has two stages: word learning and dimensionality reduction. Word learning is to learn semantics of words based on deep learning. Dimensionality reduction is the process that representing a document as a low dimensional vector by a linear mode that is completely different from topic models. Event Model achieves state-of-the-art results on document retrieval tasks.

  19. Model Selection for Geostatistical Models

    Energy Technology Data Exchange (ETDEWEB)

    Hoeting, Jennifer A.; Davis, Richard A.; Merton, Andrew A.; Thompson, Sandra E.

    2006-02-01

    We consider the problem of model selection for geospatial data. Spatial correlation is typically ignored in the selection of explanatory variables and this can influence model selection results. For example, the inclusion or exclusion of particular explanatory variables may not be apparent when spatial correlation is ignored. To address this problem, we consider the Akaike Information Criterion (AIC) as applied to a geostatistical model. We offer a heuristic derivation of the AIC in this context and provide simulation results that show that using AIC for a geostatistical model is superior to the often used approach of ignoring spatial correlation in the selection of explanatory variables. These ideas are further demonstrated via a model for lizard abundance. We also employ the principle of minimum description length (MDL) to variable selection for the geostatistical model. The effect of sampling design on the selection of explanatory covariates is also explored.

  20. Martingale Model

    OpenAIRE

    Giandomenico, Rossano

    2006-01-01

    The model determines a stochastic continuous process as continuous limit of a stochastic discrete process so to show that the stochastic continuous process converges to the stochastic discrete process such that we can integrate it. Furthermore, the model determines the expected volatility and the expected mean so to show that the volatility and the mean are increasing function of the time.

  1. Interface models

    DEFF Research Database (Denmark)

    Ravn, Anders P.; Staunstrup, Jørgen

    1994-01-01

    This paper proposes a model for specifying interfaces between concurrently executing modules of a computing system. The model does not prescribe a particular type of communication protocol and is aimed at describing interfaces between both software and hardware modules or a combination of the two...

  2. Dispersion Modeling.

    Science.gov (United States)

    Budiansky, Stephen

    1980-01-01

    This article discusses the need for more accurate and complete input data and field verification of the various models of air pollutant dispension. Consideration should be given to changing the form of air quality standards based on enhanced dispersion modeling techniques. (Author/RE)

  3. Animal models

    DEFF Research Database (Denmark)

    Gøtze, Jens Peter; Krentz, Andrew

    2014-01-01

    In this issue of Cardiovascular Endocrinology, we are proud to present a broad and dedicated spectrum of reviews on animal models in cardiovascular disease. The reviews cover most aspects of animal models in science from basic differences and similarities between small animals and the human...... pathology, to biomarkers in diagnosis and prognostic evaluation, to drug testing and targeted medicine....

  4. Modeling Sunspots

    Science.gov (United States)

    Oh, Phil Seok; Oh, Sung Jin

    2013-01-01

    Modeling in science has been studied by education researchers for decades and is now being applied broadly in school. It is among the scientific practices featured in the "Next Generation Science Standards" ("NGSS") (Achieve Inc. 2013). This article describes modeling activities in an extracurricular science club in a high…

  5. Didactical modelling

    DEFF Research Database (Denmark)

    Højgaard, Tomas; Hansen, Rune

    2016-01-01

    The purpose of this paper is to introduce Didactical Modelling as a research methodology in mathematics education. We compare the methodology with other approaches and argue that Didactical Modelling has its own specificity. We discuss the methodological “why” and explain why we find it useful to...

  6. Didactical modelling

    OpenAIRE

    Højgaard, Tomas; Hansen, Rune

    2016-01-01

    The purpose of this paper is to introduce Didactical Modelling as a research methodology in mathematics education. We compare the methodology with other approaches and argue that Didactical Modelling has its own specificity. We discuss the methodological “why” and explain why we find it useful to construct this approach in mathematics education research.

  7. Linguistic models and linguistic modeling.

    Science.gov (United States)

    Pedryez, W; Vasilakos, A V

    1999-01-01

    The study is concerned with a linguistic approach to the design of a new category of fuzzy (granular) models. In contrast to numerically driven identification techniques, we concentrate on budding meaningful linguistic labels (granules) in the space of experimental data and forming the ensuing model as a web of associations between such granules. As such models are designed at the level of information granules and generate results in the same granular rather than pure numeric format, we refer to them as linguistic models. Furthermore, as there are no detailed numeric estimation procedures involved in the construction of the linguistic models carried out in this way, their design mode can be viewed as that of a rapid prototyping. The underlying algorithm used in the development of the models utilizes an augmented version of the clustering technique (context-based clustering) that is centered around a notion of linguistic contexts-a collection of fuzzy sets or fuzzy relations defined in the data space (more precisely a space of input variables). The detailed design algorithm is provided and contrasted with the standard modeling approaches commonly encountered in the literature. The usefulness of the linguistic mode of system modeling is discussed and illustrated with the aid of numeric studies including both synthetic data as well as some time series dealing with modeling traffic intensity over a broadband telecommunication network.

  8. OSPREY Model

    Energy Technology Data Exchange (ETDEWEB)

    Veronica J. Rutledge

    2013-01-01

    The absence of industrial scale nuclear fuel reprocessing in the U.S. has precluded the necessary driver for developing the advanced simulation capability now prevalent in so many other countries. Thus, it is essential to model complex series of unit operations to simulate, understand, and predict inherent transient behavior and feedback loops. A capability of accurately simulating the dynamic behavior of advanced fuel cycle separation processes will provide substantial cost savings and many technical benefits. The specific fuel cycle separation process discussed in this report is the off-gas treatment system. The off-gas separation consists of a series of scrubbers and adsorption beds to capture constituents of interest. Dynamic models are being developed to simulate each unit operation involved so each unit operation can be used as a stand-alone model and in series with multiple others. Currently, an adsorption model has been developed within Multi-physics Object Oriented Simulation Environment (MOOSE) developed at the Idaho National Laboratory (INL). Off-gas Separation and REcoverY (OSPREY) models the adsorption of off-gas constituents for dispersed plug flow in a packed bed under non-isothermal and non-isobaric conditions. Inputs to the model include gas, sorbent, and column properties, equilibrium and kinetic data, and inlet conditions. The simulation outputs component concentrations along the column length as a function of time from which breakthrough data is obtained. The breakthrough data can be used to determine bed capacity, which in turn can be used to size columns. It also outputs temperature along the column length as a function of time and pressure drop along the column length. Experimental data and parameters were input into the adsorption model to develop models specific for krypton adsorption. The same can be done for iodine, xenon, and tritium. The model will be validated with experimental breakthrough curves. Customers will be given access to

  9. Stereometric Modelling

    Science.gov (United States)

    Grimaldi, P.

    2012-07-01

    These mandatory guidelines are provided for preparation of papers accepted for publication in the series of Volumes of The The stereometric modelling means modelling achieved with : - the use of a pair of virtual cameras, with parallel axes and positioned at a mutual distance average of 1/10 of the distance camera-object (in practice the realization and use of a stereometric camera in the modeling program); - the shot visualization in two distinct windows - the stereoscopic viewing of the shot while modelling. Since the definition of "3D vision" is inaccurately referred to as the simple perspective of an object, it is required to add the word stereo so that "3D stereo vision " shall stand for "three-dimensional view" and ,therefore, measure the width, height and depth of the surveyed image. Thanks to the development of a stereo metric model , either real or virtual, through the "materialization", either real or virtual, of the optical-stereo metric model made visible with a stereoscope. It is feasible a continuous on line updating of the cultural heritage with the help of photogrammetry and stereometric modelling. The catalogue of the Architectonic Photogrammetry Laboratory of Politecnico di Bari is available on line at: http://rappresentazione.stereofot.it:591/StereoFot/FMPro?-db=StereoFot.fp5&-lay=Scheda&-format=cerca.htm&-view

  10. Model-Driven Development for scientific computing. An upgrade of the RHEEDGr program

    Science.gov (United States)

    Daniluk, Andrzej

    2009-11-01

    program have been improved. Summary of revisions: Model-Driven Architecture (MDA) is the approach defined by the Object Management Group (OMG) for software development under the Model-Driven Engineering framework [1]. The MDA approach shifts the focus of software development from writing code to building models. By adapting a model-centric approach, the MDA approach hopes to automate the generation of system implementation artifacts directly from the model. The following three models are the core of the MDA: (i) the Computation Independent Model (CIM), which is focused on basic requirements of the system, (ii) the Platform Independent Model (PIM), which is used by software architects and designers, and is focused on the operational capabilities of a system outside the context of a specific platform, and (iii) the Platform Specific Model (PSM), which is used by software developers and programmers, and includes details relating to the system for a specific platform. Basic requirements for the calculation of the RHEED intensity rocking curves in the one-beam condition have been described in Ref. [2]. Fig. 1 shows the PIM for the present version of the program. Fig. 2 presents the PSM for the program. The TGraph2D.bpk package has been recompiled to Graph2D0x.bpl and upgraded according to C++0x language standards. Fig. 3 shows the PSM of the Graph2D component, which is manifested by the Graph2D0x.bpl package presently. This diagram is a graphic presentation of the static view, which shows a collection of declarative model elements and their relationships. Installation instructions of the Graph2D0x package can be found in the new distribution. The program requires the user to provide the appropriate parameters for the crystal structure under investigation. These parameters are loaded from the parameters.ini file at run-time. Instructions for the preparation of the .ini files can be found in the new distribution. The program enables carrying out one-dimensional dynamical

  11. A Model for Math Modeling

    Science.gov (United States)

    Lin, Tony; Erfan, Sasan

    2016-01-01

    Mathematical modeling is an open-ended research subject where no definite answers exist for any problem. Math modeling enables thinking outside the box to connect different fields of studies together including statistics, algebra, calculus, matrices, programming and scientific writing. As an integral part of society, it is the foundation for many…

  12. Scheduling of a computer integrated manufacturing system: A simulation study

    Directory of Open Access Journals (Sweden)

    Nadia Bhuiyan

    2011-12-01

    Full Text Available Purpose: The purpose of this paper is to study the effect of selected scheduling dispatching rules on the performance of an actual CIM system using different performance measures and to compare the results with the literature.Design/methodology/approach: To achieve this objective, a computer simulation model of the existing CIM system is developed to test the performance of different scheduling rules with respect to mean flow time, machine efficiency and total run time as performance measures.Findings: Results suggest that the system performs much better considering the machine efficiency when the initial number of parts released is maximum and the buffer size is minimum. Furthermore, considering the average flow time, the system performs much better when the selected dispatching rule is either Earliest Due Date (EDD or Shortest Process Time (SPT with buffer size of five and the initial number of parts released of eight.Research limitations/implications: In this research, some limitations are: a limited number of factors and levels were considered for the experiment set-up; however the flexibility of the model allows experimenting with additional factors and levels. In the simulation experiments of this research, three scheduling dispatching rules (First In/First Out (FIFO, EDD, SPT were used. In future research, the effect of other dispatching rules on the system performance can be compared. Some assumptions can be relaxed in future work.Practical implications: This research helps to identify the potential effect of a selected number of dispatching rules and two other factors, the number of buffers and initial number of parts released, on the performance of the existing CIM systems with different part types where the machines are the major resource constraints.Originality/value: This research is among the few to study the effect of the dispatching rules on the performance of the CIM systems with use of terminating simulation analysis. This is

  13. Modelling Constructs

    DEFF Research Database (Denmark)

    Kindler, Ekkart

    2009-01-01

    There are many different notations and formalisms for modelling business processes and workflows. These notations and formalisms have been introduced with different purposes and objectives. Later, influenced by other notations, comparisons with other tools, or by standardization efforts, these no...

  14. Model theory

    CERN Document Server

    Hodges, Wilfrid

    1993-01-01

    An up-to-date and integrated introduction to model theory, designed to be used for graduate courses (for students who are familiar with first-order logic), and as a reference for more experienced logicians and mathematicians.

  15. Paleoclimate Modeling

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Computer simulations of past climate. Variables provided as model output are described by parameter keyword. In some cases the parameter keywords are a subset of all...

  16. Stream Modelling

    DEFF Research Database (Denmark)

    Vestergaard, Kristian

    the engineers, but as the scale and the complexity of the hydraulic works increased, the mathematical models became so complex that a mathematical solution could not be obtained. This created a demand for new methods and again the experimental investigation became popular, but this time as measurements on small......-scale models. But still the scale and complexity of hydraulic works were increasing, and soon even small-scale models reached a natural limit for some applications. In the mean time the modern computer was developed, and it became possible to solve complex mathematical models by use of computer-based numerical......The development of the digital computer has been of great importance for the hydraulic engineer. Through many centuries hydraulic engineering was based on practical know-how, obtained through many hundred years experience. Gradually mathematical theories were introduced and accepted among...

  17. Anchor Modeling

    Science.gov (United States)

    Regardt, Olle; Rönnbäck, Lars; Bergholtz, Maria; Johannesson, Paul; Wohed, Petia

    Maintaining and evolving data warehouses is a complex, error prone, and time consuming activity. The main reason for this state of affairs is that the environment of a data warehouse is in constant change, while the warehouse itself needs to provide a stable and consistent interface to information spanning extended periods of time. In this paper, we propose a modeling technique for data warehousing, called anchor modeling, that offers non-destructive extensibility mechanisms, thereby enabling robust and flexible management of changes in source systems. A key benefit of anchor modeling is that changes in a data warehouse environment only require extensions, not modifications, to the data warehouse. This ensures that existing data warehouse applications will remain unaffected by the evolution of the data warehouse, i.e. existing views and functions will not have to be modified as a result of changes in the warehouse model.

  18. Linear Models

    CERN Document Server

    Searle, Shayle R

    2012-01-01

    This 1971 classic on linear models is once again available--as a Wiley Classics Library Edition. It features material that can be understood by any statistician who understands matrix algebra and basic statistical methods.

  19. Accelerated life models modeling and statistical analysis

    CERN Document Server

    Bagdonavicius, Vilijandas

    2001-01-01

    Failure Time DistributionsIntroductionParametric Classes of Failure Time DistributionsAccelerated Life ModelsIntroductionGeneralized Sedyakin's ModelAccelerated Failure Time ModelProportional Hazards ModelGeneralized Proportional Hazards ModelsGeneralized Additive and Additive-Multiplicative Hazards ModelsChanging Shape and Scale ModelsGeneralizationsModels Including Switch-Up and Cycling EffectsHeredity HypothesisSummaryAccelerated Degradation ModelsIntroductionDegradation ModelsModeling the Influence of Explanatory Varia

  20. Acute liver acetaminophen toxicity in rabbits and the use of antidotes: a metabonomic approach in serum.

    Science.gov (United States)

    Zira, Athina; Mikros, Emmanuel; Giannioti, Konstantina; Galanopoulou, Panagiota; Papalois, Apostolos; Liapi, Charis; Theocharis, Stamatios

    2009-07-01

    The metabonomic approach has been widely used in toxicology to investigate mechanisms of toxicity. In the present study alterations in the metabolic profiles, monitored by (1)H-NMR spectroscopy, on serum samples in acetaminophen (APAP)-induced liver injury in rabbits were examined. Furthermore, the effect of the established antidote N-acetylcysteine (NAC) and the proposed antidotes silybinin (SIL), cimetidine (CIM) and SIL/CIM was also investigated. A single dose of APAP (2 g kg(-1) b.w., i.g.) was administered to rabbits and APAP combined with the antidotes SIL, CIM and NAC. Animals were sacrificed at 24 h post-APAP treatment. Healthy untreated animals served as controls. (1)H-NMR spectra of serum samples were acquired and underwent principal component analysis (PCA). Acute liver injury was verified by histopathological examination and the alterations of serum biochemical enzymes AST and ALT. (1)H-NMR spectroscopy revealed variations in the serum metabolic profile of APAP-intoxicated rabbits compared with controls. Co-administration of APAP with NAC, CIM and SIL + CIM seems to ameliorate the metabolic profile of animals compared with simply APAP-treated ones. In this study, the model of APAPinduced liver injury was successfully described using the (1)H-NMR based metabonomic approach in serum. Furthermore, the use of antidotes that reduced the toxic insult was also recorded using this technique. The combination of NMR spectroscopy and PCA is a rapid methodology, capable of detecting alterations in the metabolic profile, and produces adequate models that could be used for the characterization of unknown samples, both experimental and clinical, reinforcing its future use in clinical settings.

  1. Do stroke models model stroke?

    Directory of Open Access Journals (Sweden)

    Philipp Mergenthaler

    2012-11-01

    Full Text Available Stroke is one of the leading causes of death worldwide and the biggest reason for long-term disability. Basic research has formed the modern understanding of stroke pathophysiology, and has revealed important molecular, cellular and systemic mechanisms. However, despite decades of research, most translational stroke trials that aim to introduce basic research findings into clinical treatment strategies – most notably in the field of neuroprotection – have failed. Among other obstacles, poor methodological and statistical standards, negative publication bias, and incomplete preclinical testing have been proposed as ‘translational roadblocks’. In this article, we introduce the models commonly used in preclinical stroke research, discuss some of the causes of failed translational success and review potential remedies. We further introduce the concept of modeling ‘care’ of stroke patients, because current preclinical research models the disorder but does not model care or state-of-the-art clinical testing. Stringent statistical methods and controlled preclinical trials have been suggested to counteract weaknesses in preclinical research. We conclude that preclinical stroke research requires (1 appropriate modeling of the disorder, (2 appropriate modeling of the care of stroke patients and (3 an approach to preclinical testing that is similar to clinical testing, including Phase 3 randomized controlled preclinical trials as necessary additional steps before new therapies enter clinical testing.

  2. Inflatable Models

    Institute of Scientific and Technical Information of China (English)

    Ling Li; Vasily Volkov

    2006-01-01

    A physically-based model is presented for the simulation of a new type of deformable objects-inflatable objects, such as shaped balloons, which consist of pressurized air enclosed by an elastic surface. These objects have properties inherent in both 3D and 2D elastic bodies, as they demonstrate the behaviour of 3D shapes using 2D formulations. As there is no internal structure in them, their behaviour is substantially different from the behaviour of deformable solid objects. We use one of the few available models for deformable surfaces, and enhance it to include the forces of internal and external pressure. These pressure forces may also incorporate buoyancy forces, to allow objects filled with a low density gas to float in denser media. The obtained models demonstrate rich dynamic behaviour, such as bouncing, floating, deflation and inflation.

  3. Lens Model

    DEFF Research Database (Denmark)

    Nash, Ulrik William

    2014-01-01

    Firms consist of people who make decisions to achieve goals. How do these people develop the expectations which underpin the choices they make? The lens model provides one answer to this question. It was developed by cognitive psychologist Egon Brunswik (1952) to illustrate his theory of probabil......Firms consist of people who make decisions to achieve goals. How do these people develop the expectations which underpin the choices they make? The lens model provides one answer to this question. It was developed by cognitive psychologist Egon Brunswik (1952) to illustrate his theory...... of probabilistic functionalism, and concerns the environment and the mind, and adaptation by the latter to the former. This entry is about the lens model, and probabilistic functionalism more broadly. Focus will mostly be on firms and their employees, but, to fully appreciate the scope, we have to keep in mind...

  4. SPECTRUM OF CERVICAL LESIONS IN CIMS, BILASPUR: A 5 YEAR RETROSPECTIVE STUDY OF 215 CASES IN A TERTIARY HOSPITAL OF CENTRAL INDIA

    Directory of Open Access Journals (Sweden)

    Sadhna

    2015-10-01

    Full Text Available BACKGROUND AND OBJEC TIVE: Cancer of the cervix is a leading cause of morbidity and mortality among women W orld W ide. Therefore to curb the disease there is need of awareness of this disease. This study is aimed to categorize the premalignant and malignant lesions at the earliest, to reduce the mortality and morbidity. It also aimed to know the incidence of malignancies at our set up and to calculate distribution of patient in relation to parity and symptoms. DESIGN AND SETTING: Study included 215 patients with complain of white dis charge per vagina, per vaginal bleeding and backache attending the gynecology OPD over a period of 05 years. PATIENT AND METHODS: Patients were subjected to cervical biopsy and biopsies were sent to pathology department. Detailed clinical history, age, age at marriage, parity and socio - economic status was obtained. RESULT: Result were classified histopathological l y as inflammatory lesions 70 cases, polypoidal lesion were 30, LSIL accounted for 32 cases and HSIL were 20 cases and 30 were malignant lesions. U nder malignant category moderately differentiated squamous cell carcinoma was the commonest. Maximum numbers of patients were subjected to cervical biopsies in 3 rd decade of life. Malignancies were common in 3 rd & 4 th decade of life. Most of the cases were of parity 4. CONCLUSION : Tissue biopsy is a valuable diagnostic procedure on which surgeons and radiologists still rely.

  5. Build Oilfield Specialized Information System by Using CIMS Technique%利用CIMS技术构建油田专业信息系统

    Institute of Scientific and Technical Information of China (English)

    刘建平; 李林苍; 卢刚; 马宏伟; 袁鲁

    2002-01-01

    CIMS(Computer Integrated Manufacturing System计算机集成制造系统),这一概念最先由美国Harrington博士于1973年提出,它是信息时代企业生产,客管理的最新技术模式,代表着企业今后的发展方向。CIMS技术的基本思路是:利用当今先进的计算机集成手段,把企业中各个环节的人员,信息,技术,组织等计算机应用资源有机地组织和协调集成,使松散的单一企业功能资源群体,变为紧密结合的统一整体性开放式应用系统;充分发挥其在企业自身中的总体优势作用,达到提高企业效益,赢得企业发展的目的。

  6. CIM(®) monolithic anion-exchange chromatography as a useful alternative to CsCl gradient purification of bacteriophage particles.

    Science.gov (United States)

    Adriaenssens, Evelien M; Lehman, Susan M; Vandersteegen, Katrien; Vandenheuvel, Dieter; Philippe, Didier L; Cornelissen, Anneleen; Clokie, Martha R J; García, Andrés J; De Proft, Maurice; Maes, Martine; Lavigne, Rob

    2012-12-20

    The use of anion-exchange chromatography was investigated as an alternative method to concentrate and purify bacterial viruses, and parameters for different bacteriophages were compared. Chromatography was performed with Convective Interactive Media(®) monoliths, with three different volumes and two matrix chemistries. Eleven morphologically distinct phages were tested, infecting five different bacterial species. For each of the phages tested, a protocol was optimized, including the choice of column chemistry, loading, buffer and elution conditions. The capacity and recovery of the phages on the columns varied considerably between phages. We conclude that anion-exchange chromatography with monoliths is a valid alternative to the more traditional CsCl purification, has upscaling advantages, but it requires more extensive optimization.

  7. Main characteristics and construction of CIMS in cigarette enterprise%卷烟企业CIMS工程的主要特点与构成

    Institute of Scientific and Technical Information of China (English)

    薛劲松; 黄炎

    2001-01-01

    介绍了CIMS的主要概念及典型的CIMS构成,分析了卷烟企业的生产流程和实施CIMS工程的主要特点.根据实施CIMS企业的实际情况,探讨了卷烟企业CIMS的构成,重点介绍了集成在卷烟企业CIMS工程中的作用,为卷烟企业CIMS工程的实施提供参考.

  8. Risk Analysis and Investment Decision Assessment About CIMS%CIMS风险分析与投资决策评价方法

    Institute of Scientific and Technical Information of China (English)

    王旭; 周秀丽

    2000-01-01

    CIMS应用工程是人/组织、技术和企业经营管理有机集成的系统工程,也是一项创新工程,其目标是增强企业的市场应变和竞争能力.由于CIMS应用工程实施过程中不确定性因素很多,因此企业为此项目投资可能会带来巨大的风险.在国内外对CIMS研究的基础上,结合国内CIMS应用工程实施,建立了CIMS应用工程风险评价指标体系,提出了CIMS投资决策综合评价方法,并应用在企业的CIMS工程中.

  9. 机械制造中CIMS的重要作用和发展趋势%The important function and developing tendency of CIMS in mechanical manufacturing

    Institute of Scientific and Technical Information of China (English)

    张海平

    2002-01-01

    对CIMS的原理、构成和应用进行了分析和研究,说明其构成中CAD、CAM、CAPP和CIMS之间相互关系,阐述了CIMS技术对机械制造企业活动的主要作用和该项技术的发展趋势,指出CIMS的主要功能活动是信息进行集成和控制,根据现实考虑应加强CIMS技术的研究和推广.

  10. Molecular modeling

    Directory of Open Access Journals (Sweden)

    Aarti Sharma

    2009-01-01

    Full Text Available The use of computational chemistry in the development of novel pharmaceuticals is becoming an increasingly important tool. In the past, drugs were simply screened for effectiveness. The recent advances in computing power and the exponential growth of the knowledge of protein structures have made it possible for organic compounds to be tailored to decrease the harmful side effects and increase the potency. This article provides a detailed description of the techniques employed in molecular modeling. Molecular modeling is a rapidly developing discipline, and has been supported by the dramatic improvements in computer hardware and software in recent years.

  11. Modelling language

    CERN Document Server

    Cardey, Sylviane

    2013-01-01

    In response to the need for reliable results from natural language processing, this book presents an original way of decomposing a language(s) in a microscopic manner by means of intra/inter‑language norms and divergences, going progressively from languages as systems to the linguistic, mathematical and computational models, which being based on a constructive approach are inherently traceable. Languages are described with their elements aggregating or repelling each other to form viable interrelated micro‑systems. The abstract model, which contrary to the current state of the art works in int

  12. Smashnova Model

    CERN Document Server

    Sivaram, C

    2007-01-01

    An alternate model for gamma ray bursts is suggested. For a white dwarf (WD) and neutron star (NS) very close binary system, the WD (close to Mch) can detonate due to tidal heating, leading to a SN. Material falling on to the NS at relativistic velocities can cause its collapse to a magnetar or quark star or black hole leading to a GRB. As the material smashes on to the NS, it is dubbed the Smashnova model. Here the SN is followed by a GRB. NS impacting a RG (or RSG) (like in Thorne-Zytkow objects) can also cause a SN outburst followed by a GRB. Other variations are explored.

  13. Building Models and Building Modelling

    DEFF Research Database (Denmark)

    Jørgensen, Kaj Asbjørn; Skauge, Jørn

    I rapportens indledende kapitel beskrives de primære begreber vedrørende bygningsmodeller og nogle fundamentale forhold vedrørende computerbaseret modulering bliver opstillet. Desuden bliver forskellen mellem tegneprogrammer og bygnings­model­lerings­programmer beskrevet. Vigtige aspekter om......­lering og bygningsmodeller. Det bliver understreget at modellering bør udføres på flere abstraktions­niveauer og i to dimensioner i den såkaldte modelleringsmatrix. Ud fra dette identificeres de primære faser af bygningsmodel­lering. Dernæst beskrives de basale karakteristika for bygningsmodeller. Heri...... inkluderes en præcisering af begreberne objektorienteret software og objektorienteret modeller. Det bliver fremhævet at begrebet objektbaseret modellering giver en tilstrækkelig og bedre forståelse. Endelig beskrives forestillingen om den ideale bygningsmodel som værende én samlet model, der anvendes gennem...

  14. Modeling Muscles

    Science.gov (United States)

    Goodwyn, Lauren; Salm, Sarah

    2007-01-01

    Teaching the anatomy of the muscle system to high school students can be challenging. Students often learn about muscle anatomy by memorizing information from textbooks or by observing plastic, inflexible models. Although these mediums help students learn about muscle placement, the mediums do not facilitate understanding regarding integration of…

  15. Painting models

    Science.gov (United States)

    Baart, F.; Donchyts, G.; van Dam, A.; Plieger, M.

    2015-12-01

    The emergence of interactive art has blurred the line between electronic, computer graphics and art. Here we apply this art form to numerical models. Here we show how the transformation of a numerical model into an interactive painting can both provide insights and solve real world problems. The cases that are used as an example include forensic reconstructions, dredging optimization, barrier design. The system can be fed using any source of time varying vector fields, such as hydrodynamic models. The cases used here, the Indian Ocean (HYCOM), the Wadden Sea (Delft3D Curvilinear), San Francisco Bay (3Di subgrid and Delft3D Flexible Mesh), show that the method used is suitable for different time and spatial scales. High resolution numerical models become interactive paintings by exchanging their velocity fields with a high resolution (>=1M cells) image based flow visualization that runs in a html5 compatible web browser. The image based flow visualization combines three images into a new image: the current image, a drawing, and a uv + mask field. The advection scheme that computes the resultant image is executed in the graphics card using WebGL, allowing for 1M grid cells at 60Hz performance on mediocre graphic cards. The software is provided as open source software. By using different sources for a drawing one can gain insight into several aspects of the velocity fields. These aspects include not only the commonly represented magnitude and direction, but also divergence, topology and turbulence .

  16. Entrepreneurship Models.

    Science.gov (United States)

    Finger Lakes Regional Education Center for Economic Development, Mount Morris, NY.

    This guide describes seven model programs that were developed by the Finger Lakes Regional Center for Economic Development (New York) to meet the training needs of female and minority entrepreneurs to help their businesses survive and grow and to assist disabled and dislocated workers and youth in beginning small businesses. The first three models…

  17. Model CAPM

    OpenAIRE

    Burianová, Eva

    2008-01-01

    Cílem první části této bakalářské práce je - pomocí analýzy výchozích textů - teoretické shrnutí ekonomických modelů a teorií, na kterých model CAPM stojí: Markowitzův model teorie portfolia (analýza maximalizace očekávaného užitku a na něm založený model výběru optimálního portfolia), Tobina (rozšíření Markowitzova modelu ? rozdělení výběru optimálního portfolia do dvou fází; nejprve určení optimální kombinace rizikových instrumentů a následná alokace dostupného kapitálu mezi tuto optimální ...

  18. Zeebrugge Model

    DEFF Research Database (Denmark)

    Jensen, Morten S.; Frigaard, Peter

    In the following, results from model tests with Zeebrugge breakwater are presented. The objective with these tests is partly to investigate the influence on wave run-up due to a changing waterlevel during a storm. Finally, the influence on wave run-up due to an introduced longshore current...

  19. Transport modeling

    Institute of Scientific and Technical Information of China (English)

    R.E. Waltz

    2007-01-01

    @@ There has been remarkable progress during the past decade in understanding and modeling turbulent transport in tokamaks. With some exceptions the progress is derived from the huge increases in computational power and the ability to simulate tokamak turbulence with ever more fundamental and physically realistic dynamical equations, e.g.

  20. Persistent Modelling

    DEFF Research Database (Denmark)

    2012-01-01

    The relationship between representation and the represented is examined here through the notion of persistent modelling. This notion is not novel to the activity of architectural design if it is considered as describing a continued active and iterative engagement with design concerns – an evident...

  1. Why Model?

    Directory of Open Access Journals (Sweden)

    Olaf eWolkenhauer

    2014-01-01

    Full Text Available Next generation sequencing technologies are bringing about a renaissance of mining approaches. A comprehensive picture of the genetic landscape of an individual patient will be useful, for example, to identify groups of patients that do or do not respond to certain therapies. The high expectations may however not be satisfied if the number of patient groups with similar characteristics is going to be very large. I therefore doubt that mining sequence data will give us an understanding of why and when therapies work. For understanding the mechanisms underlying diseases, an alternative approach is to model small networks in quantitative mechanistic detail, to elucidate the role of gene and proteins in dynamically changing the functioning of cells. Here an obvious critique is that these models consider too few components, compared to what might be relevant for any particular cell function. I show here that mining approaches and dynamical systems theory are two ends of a spectrum of methodologies to choose from. Drawing upon personal experience in numerous interdisciplinary collaborations, I provide guidance on how to model by discussing the question Why model?

  2. Why model?

    Science.gov (United States)

    Wolkenhauer, Olaf

    2014-01-01

    Next generation sequencing technologies are bringing about a renaissance of mining approaches. A comprehensive picture of the genetic landscape of an individual patient will be useful, for example, to identify groups of patients that do or do not respond to certain therapies. The high expectations may however not be satisfied if the number of patient groups with similar characteristics is going to be very large. I therefore doubt that mining sequence data will give us an understanding of why and when therapies work. For understanding the mechanisms underlying diseases, an alternative approach is to model small networks in quantitative mechanistic detail, to elucidate the role of gene and proteins in dynamically changing the functioning of cells. Here an obvious critique is that these models consider too few components, compared to what might be relevant for any particular cell function. I show here that mining approaches and dynamical systems theory are two ends of a spectrum of methodologies to choose from. Drawing upon personal experience in numerous interdisciplinary collaborations, I provide guidance on how to model by discussing the question "Why model?"

  3. Criticality Model

    Energy Technology Data Exchange (ETDEWEB)

    A. Alsaed

    2004-09-14

    The ''Disposal Criticality Analysis Methodology Topical Report'' (YMP 2003) presents the methodology for evaluating potential criticality situations in the monitored geologic repository. As stated in the referenced Topical Report, the detailed methodology for performing the disposal criticality analyses will be documented in model reports. Many of the models developed in support of the Topical Report differ from the definition of models as given in the Office of Civilian Radioactive Waste Management procedure AP-SIII.10Q, ''Models'', in that they are procedural, rather than mathematical. These model reports document the detailed methodology necessary to implement the approach presented in the Disposal Criticality Analysis Methodology Topical Report and provide calculations utilizing the methodology. Thus, the governing procedure for this type of report is AP-3.12Q, ''Design Calculations and Analyses''. The ''Criticality Model'' is of this latter type, providing a process evaluating the criticality potential of in-package and external configurations. The purpose of this analysis is to layout the process for calculating the criticality potential for various in-package and external configurations and to calculate lower-bound tolerance limit (LBTL) values and determine range of applicability (ROA) parameters. The LBTL calculations and the ROA determinations are performed using selected benchmark experiments that are applicable to various waste forms and various in-package and external configurations. The waste forms considered in this calculation are pressurized water reactor (PWR), boiling water reactor (BWR), Fast Flux Test Facility (FFTF), Training Research Isotope General Atomic (TRIGA), Enrico Fermi, Shippingport pressurized water reactor, Shippingport light water breeder reactor (LWBR), N-Reactor, Melt and Dilute, and Fort Saint Vrain Reactor spent nuclear fuel (SNF). The scope of

  4. Information Model for Product Modeling

    Institute of Scientific and Technical Information of China (English)

    焦国方; 刘慎权

    1992-01-01

    The Key problems in product modeling for integrated CAD ∥CAM systems are the information structures and representations of products.They are taking more and more important roles in engineering applications.With the investigation on engineering product information and from the viewpoint of industrial process,in this paper,the information models are proposed and the definitions of the framework of product information are given.And then,the integration and the consistence of product information are discussed by introucing the entity and its instance.As a summary,the information structures described in this paper have many advantage and natures helpful in engineering design.

  5. Molecular Modelling

    Directory of Open Access Journals (Sweden)

    Aarti Sharma

    2009-12-01

    Full Text Available

    The use of computational chemistry in the development of novel pharmaceuticals is becoming an increasingly important
    tool. In the past, drugs were simply screened for effectiveness. The recent advances in computing power and
    the exponential growth of the knowledge of protein structures have made it possible for organic compounds to tailored to
    decrease harmful side effects and increase the potency. This article provides a detailed description of the techniques
    employed in molecular modeling. Molecular modelling is a rapidly developing discipline, and has been supported from
    the dramatic improvements in computer hardware and software in recent years.

  6. Cheating models

    DEFF Research Database (Denmark)

    Arnoldi, Jakob

    The article discusses the use of algorithmic models for so-called High Frequency Trading (HFT) in finance. HFT is controversial yet widespread in modern financial markets. It is a form of automated trading technology which critics among other things claim can lead to market manipulation. Drawing...... on two cases, this article shows that manipulation more likely happens in the reverse way, meaning that human traders attempt to make algorithms ‘make mistakes’ or ‘mislead’ algos. Thus, it is algorithmic models, not humans, that are manipulated. Such manipulation poses challenges for security exchanges....... The article analyses these challenges and argues that we witness a new post-social form of human-technology interaction that will lead to a reconfiguration of professional codes for financial trading....

  7. Modelling Behaviour

    DEFF Research Database (Denmark)

    2015-01-01

    posing new challenges in all areas of the industry from material and structural to the urban scale. Contributions from invited experts, papers and case studies provide the reader with a comprehensive overview of the field, as well as perspectives from related disciplines, such as computer science....... The chapter authors were invited speakers at the 5th Symposium "Modelling Behaviour", which took place at the CITA in Copenhagen in September 2015....

  8. Nuclear Models

    Science.gov (United States)

    Fossión, Rubén

    2010-09-01

    The atomic nucleus is a typical example of a many-body problem. On the one hand, the number of nucleons (protons and neutrons) that constitute the nucleus is too large to allow for exact calculations. On the other hand, the number of constituent particles is too small for the individual nuclear excitation states to be explained by statistical methods. Another problem, particular for the atomic nucleus, is that the nucleon-nucleon (n-n) interaction is not one of the fundamental forces of Nature, and is hard to put in a single closed equation. The nucleon-nucleon interaction also behaves differently between two free nucleons (bare interaction) and between two nucleons in the nuclear medium (dressed interaction). Because of the above reasons, specific nuclear many-body models have been devised of which each one sheds light on some selected aspects of nuclear structure. Only combining the viewpoints of different models, a global insight of the atomic nucleus can be gained. In this chapter, we revise the the Nuclear Shell Model as an example of the microscopic approach, and the Collective Model as an example of the geometric approach. Finally, we study the statistical properties of nuclear spectra, basing on symmetry principles, to find out whether there is quantum chaos in the atomic nucleus. All three major approaches have been rewarded with the Nobel Prize of Physics. In the text, we will stress how each approach introduces its own series of approximations to reduce the prohibitingly large number of degrees of freedom of the full many-body problem to a smaller manageable number of effective degrees of freedom.

  9. Modeling biomembranes.

    Energy Technology Data Exchange (ETDEWEB)

    Plimpton, Steven James; Heffernan, Julieanne; Sasaki, Darryl Yoshio; Frischknecht, Amalie Lucile; Stevens, Mark Jackson; Frink, Laura J. Douglas

    2005-11-01

    Understanding the properties and behavior of biomembranes is fundamental to many biological processes and technologies. Microdomains in biomembranes or ''lipid rafts'' are now known to be an integral part of cell signaling, vesicle formation, fusion processes, protein trafficking, and viral and toxin infection processes. Understanding how microdomains form, how they depend on membrane constituents, and how they act not only has biological implications, but also will impact Sandia's effort in development of membranes that structurally adapt to their environment in a controlled manner. To provide such understanding, we created physically-based models of biomembranes. Molecular dynamics (MD) simulations and classical density functional theory (DFT) calculations using these models were applied to phenomena such as microdomain formation, membrane fusion, pattern formation, and protein insertion. Because lipid dynamics and self-organization in membranes occur on length and time scales beyond atomistic MD, we used coarse-grained models of double tail lipid molecules that spontaneously self-assemble into bilayers. DFT provided equilibrium information on membrane structure. Experimental work was performed to further help elucidate the fundamental membrane organization principles.

  10. 75 FR 40023 - Notice of Fiscal Year 2011 Safety Grants and Solicitation for Applications

    Science.gov (United States)

    2010-07-13

    ... Priority Grants--Cim Weiss, cim.weiss@dot.gov , 202-366-0275 CMV Operator Safety Training Grants--Julie...-3030 SaDIP Grants--Cim Weiss, cim.weiss@dot.gov , 202-366-0275 PRISM Grants--Tom Lawler,...

  11. Model Construct Based Enterprise Model Architecture and Its Modeling Approach

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    In order to support enterprise integration, a kind of model construct based enterprise model architecture and its modeling approach are studied in this paper. First, the structural makeup and internal relationships of enterprise model architecture are discussed. Then, the concept of reusable model construct (MC) which belongs to the control view and can help to derive other views is proposed. The modeling approach based on model construct consists of three steps, reference model architecture synthesis, enterprise model customization, system design and implementation. According to MC based modeling approach a case study with the background of one-kind-product machinery manufacturing enterprises is illustrated. It is shown that proposal model construct based enterprise model architecture and modeling approach are practical and efficient.

  12. A Model

    Institute of Scientific and Technical Information of China (English)

    Liu Zhiyang

    2011-01-01

    Similar to ISO Technical Committees,SAC Technical Committees undertake the management and coordination of standard's development and amendments in various sectors in industry,playing the role as a bridge among enterprises,research institutions and the governmental standardization administration.How to fully play the essential role is the vital issue SAC has been committing to resolve.Among hundreds of SAC TCs,one stands out in knitting together those isolated,scattered,but highly competitive enterprises in the same industry with the "Standards" thread,and achieving remarkable results in promoting industry development with standardization.It sets a role model for other TCs.

  13. Modelling Behaviour

    DEFF Research Database (Denmark)

    2015-01-01

    This book reflects and expands on the current trend in the building industry to understand, simulate and ultimately design buildings by taking into consideration the interlinked elements and forces that act on them. This approach overcomes the traditional, exclusive focus on building tasks, while....... The chapter authors were invited speakers at the 5th Symposium "Modelling Behaviour", which took place at the CITA in Copenhagen in September 2015....... posing new challenges in all areas of the industry from material and structural to the urban scale. Contributions from invited experts, papers and case studies provide the reader with a comprehensive overview of the field, as well as perspectives from related disciplines, such as computer science...

  14. The ARCON modeling framework

    NARCIS (Netherlands)

    H. Afsarmanesh; L.M. Camarinha-Matos

    2008-01-01

    A framework is defined for ARCON reference modeling, introducing multiple modeling perspectives of: Environment characteristics, life cycle stages, and modeling intents. This novel modeling framework takes into account contributions from previous related works, mainly on enterprise modeling, and ext

  15. On Activity modelling in process modeling

    Directory of Open Access Journals (Sweden)

    Dorel Aiordachioaie

    2001-12-01

    Full Text Available The paper is looking to the dynamic feature of the meta-models of the process modelling process, the time. Some principles are considered and discussed as main dimensions of any modelling activity: the compatibility of the substances, the equipresence of phenomena and the solvability of the model. The activity models are considered and represented at meta-level.

  16. Computational Principle and Performance Evaluation of Coherent Ising Machine Based on Degenerate Optical Parametric Oscillator Network

    Directory of Open Access Journals (Sweden)

    Yoshitaka Haribara

    2016-04-01

    Full Text Available We present the operational principle of a coherent Ising machine (CIM based on a degenerate optical parametric oscillator (DOPO network. A quantum theory of CIM is formulated, and the computational ability of CIM is evaluated by numerical simulation based on c-number stochastic differential equations. We also discuss the advanced CIM with quantum measurement-feedback control and various problems which can be solved by CIM.

  17. Towards a Multi Business Model Innovation Model

    DEFF Research Database (Denmark)

    Lindgren, Peter; Jørgensen, Rasmus

    2012-01-01

    This paper studies the evolution of business model (BM) innovations related to a multi business model framework. The paper tries to answer the research questions: • What are the requirements for a multi business model innovation model (BMIM)? • How should a multi business model innovation model...... look like? Different generations of BMIMs are initially studied in the context of laying the baseline for how next generation multi BM Innovation model (BMIM) should look like. All generations of models are analyzed with the purpose of comparing the characteristics and challenges of previous...

  18. Better Language Models with Model Merging

    CERN Document Server

    Brants, T

    1996-01-01

    This paper investigates model merging, a technique for deriving Markov models from text or speech corpora. Models are derived by starting with a large and specific model and by successively combining states to build smaller and more general models. We present methods to reduce the time complexity of the algorithm and report on experiments on deriving language models for a speech recognition task. The experiments show the advantage of model merging over the standard bigram approach. The merged model assigns a lower perplexity to the test set and uses considerably fewer states.

  19. Impedance model for nanostructures

    Directory of Open Access Journals (Sweden)

    R. S. Akhmedov

    2007-06-01

    Full Text Available The application of the impedance model for nanoelectronic quantum-mechanical structures modelling is described. Characteristics illustrating the efficiency of the model are presented.

  20. The IMACLIM model; Le modele IMACLIM

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This document provides annexes to the IMACLIM model which propose an actualized description of IMACLIM, model allowing the design of an evaluation tool of the greenhouse gases reduction policies. The model is described in a version coupled with the POLES, technical and economical model of the energy industry. Notations, equations, sources, processing and specifications are proposed and detailed. (A.L.B.)

  1. Building Mental Models by Dissecting Physical Models

    Science.gov (United States)

    Srivastava, Anveshna

    2016-01-01

    When students build physical models from prefabricated components to learn about model systems, there is an implicit trade-off between the physical degrees of freedom in building the model and the intensity of instructor supervision needed. Models that are too flexible, permitting multiple possible constructions require greater supervision to…

  2. From Ambient Sensing to IoT-based Context Computing: An Open Framework for End to End QoC Management

    Directory of Open Access Journals (Sweden)

    Pierrick Marie

    2015-06-01

    Full Text Available Quality of Context (QoC awareness is recognized as a key point for the success of context-aware computing. At the time where the combination of the Internet of Things, Cloud Computing, and Ambient Intelligence paradigms offer together new opportunities for managing richer context data, the next generation of Distributed Context Managers (DCM is facing new challenges concerning QoC management. This paper presents our model-driven QoCIM framework. QoCIM is the acronym for Quality of Context Information Model. We show how it can help application developers to manage the whole QoC life-cycle by providing genericity, openness and uniformity. Its usages are illustrated, both at design time and at runtime, in the case of an urban pollution context- and QoC-aware scenario.

  3. From Ambient Sensing to IoT-based Context Computing: An Open Framework for End to End QoC Management.

    Science.gov (United States)

    Marie, Pierrick; Desprats, Thierry; Chabridon, Sophie; Sibilla, Michelle; Taconet, Chantal

    2015-06-16

    Quality of Context (QoC) awareness is recognized as a key point for the success of context-aware computing. At the time where the combination of the Internet of Things, Cloud Computing, and Ambient Intelligence paradigms offer together new opportunities for managing richer context data, the next generation of Distributed Context Managers (DCM) is facing new challenges concerning QoC management. This paper presents our model-driven QoCIM framework. QoCIM is the acronym for Quality of Context Information Model. We show how it can help application developers to manage the whole QoC life-cycle by providing genericity, openness and uniformity. Its usages are illustrated, both at design time and at runtime, in the case of an urban pollution context- and QoC-aware scenario.

  4. Continuous Time Model Estimation

    OpenAIRE

    Carl Chiarella; Shenhuai Gao

    2004-01-01

    This paper introduces an easy to follow method for continuous time model estimation. It serves as an introduction on how to convert a state space model from continuous time to discrete time, how to decompose a hybrid stochastic model into a trend model plus a noise model, how to estimate the trend model by simulation, and how to calculate standard errors from estimation of the noise model. It also discusses the numerical difficulties involved in discrete time models that bring about the unit ...

  5. Can hydrogen win?: exploring scenarios for hydrogen fuelled vehicles

    OpenAIRE

    Muncaster, Katherine Aminta

    2008-01-01

    This study explored the conditions under which hydrogen might succeed in Canada’s transportation sector in a carbon-constrained world. Long-run simulations were created using CIMS, a hybrid energy-economy model that is technologically explicit, behaviourally realistic, and incorporates drivers of technological change. A hydrogen supply submodel was built to simulate economies of scale in infrastructure. Capital costs, technology performance, infrastructure, fuel prices, and other conditions w...

  6. Study of Synthesis Identification in Cutting Process with Fuzzy Neural Network

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    With the development of industrial production modernization, FMS and CIMS will become more and more popularized. For its control system is increasingly modeled, intellectualized and automatized, in order to raise the reliability and stability in the manufacturing process, the comprehensive monitoring and diagnosis aimed at cutting tool wear and chatter become more and more important and get rapid development. The paper tried to discuss of the intellectual status identification method based on acoustics-vi...

  7. Concurrency Control Mechanism of Complex Objects

    Institute of Scientific and Technical Information of China (English)

    徐庆云; 王能斌

    1992-01-01

    A complex object is an abstraction and description of a complex entity of the real world.Many applications in such domains as CIMS,CAD and OA define and manipulate a complex object as a single unit.In this paper,a definition of the model of complex objects is given,and the concurrency control mechanism of complex objects in WHYMX object-oriented database system is described.

  8. Research on Business Processes Optimization for Agile Manufacturing

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Based on macroscopic and synthetic approaches, especia lly information entropy approach, the quantification of the flexible degree and order degree of business processes is studied. According to the outcome of abov e analysis, a conceptual model of optimizing business processes is proposed whic h supports to construct dynamic stable business processes. The research above has been applied in project 863/SDDAC-CIMS, and achieved primary benefits.

  9. Comparative Protein Structure Modeling Using MODELLER.

    Science.gov (United States)

    Webb, Benjamin; Sali, Andrej

    2016-06-20

    Comparative protein structure modeling predicts the three-dimensional structure of a given protein sequence (target) based primarily on its alignment to one or more proteins of known structure (templates). The prediction process consists of fold assignment, target-template alignment, model building, and model evaluation. This unit describes how to calculate comparative models using the program MODELLER and how to use the ModBase database of such models, and discusses all four steps of comparative modeling, frequently observed errors, and some applications. Modeling lactate dehydrogenase from Trichomonas vaginalis (TvLDH) is described as an example. The download and installation of the MODELLER software is also described. © 2016 by John Wiley & Sons, Inc.

  10. Concept Modeling vs. Data modeling in Practice

    DEFF Research Database (Denmark)

    Madsen, Bodil Nistrup; Erdman Thomsen, Hanne

    2015-01-01

    account of the inheritance of characteristics and allows us to introduce a number of principles and constraints which render concept modeling more coherent than earlier approaches. Second, we explain how terminological ontologies can be used as the basis for developing conceptual and logical data models......This chapter shows the usefulness of terminological concept modeling as a first step in data modeling. First, we introduce terminological concept modeling with terminological ontologies, i.e. concept systems enriched with characteristics modeled as feature specifications. This enables a formal...

  11. Model Manipulation for End-User Modelers

    DEFF Research Database (Denmark)

    Acretoaie, Vlad

    of these proposals. To achieve its first goal, the thesis presents the findings of a Systematic Mapping Study showing that human factors topics are scarcely and relatively poorly addressed in model transformation research. Motivated by these findings, the thesis explores the requirements of end-user modelers......End-user modelers are domain experts who create and use models as part of their work. They are typically not Software Engineers, and have little or no programming and meta-modeling experience. However, using model manipulation languages developed in the context of Model-Driven Engineering often...... requires such experience. These languages are therefore only used by a small subset of the modelers that could, in theory, benefit from them. The goals of this thesis are to substantiate this observation, introduce the concepts and tools required to overcome it, and provide empirical evidence in support...

  12. From Product Models to Product State Models

    DEFF Research Database (Denmark)

    Larsen, Michael Holm

    1999-01-01

    A well-known technology designed to handle product data is Product Models. Product Models are in their current form not able to handle all types of product state information. Hence, the concept of a Product State Model (PSM) is proposed. The PSM and in particular how to model a PSM is the Research...... Object for this project. In the presentation, benefits and challenges of the PSM will be presented as a basis for the discussion....

  13. Measurement and Modeling: Infectious Disease Modeling

    NARCIS (Netherlands)

    Kretzschmar, MEE

    2016-01-01

    After some historical remarks about the development of mathematical theory for infectious disease dynamics we introduce a basic mathematical model for the spread of an infection with immunity. The concepts of the model are explained and the model equations are derived from first principles. Using th

  14. Modelling of Hydraulic Robot

    DEFF Research Database (Denmark)

    Madsen, Henrik; Zhou, Jianjun; Hansen, Lars Henrik

    1997-01-01

    This paper describes a case study of identifying the physical model (or the grey box model) of a hydraulic test robot. The obtained model is intended to provide a basis for model-based control of the robot. The physical model is formulated in continuous time and is derived by application...... of the laws of physics on the system. The unknown (or uncertain) parameters are estimated with Maximum Likelihood (ML) parameter estimation. The identified model has been evaluated by comparing the measurements with simulation of the model. The identified model was much more capable of describing the dynamics...... of the system than the deterministic model....

  15. "Bohr's Atomic Model."

    Science.gov (United States)

    Willden, Jeff

    2001-01-01

    "Bohr's Atomic Model" is a small interactive multimedia program that introduces the viewer to a simplified model of the atom. This interactive simulation lets students build an atom using an atomic construction set. The underlying design methodology for "Bohr's Atomic Model" is model-centered instruction, which means the central model of the…

  16. Solicited abstract: Global hydrological modeling and models

    Science.gov (United States)

    Xu, Chong-Yu

    2010-05-01

    The origins of rainfall-runoff modeling in the broad sense can be found in the middle of the 19th century arising in response to three types of engineering problems: (1) urban sewer design, (2) land reclamation drainage systems design, and (3) reservoir spillway design. Since then numerous empirical, conceptual and physically-based models are developed including event based models using unit hydrograph concept, Nash's linear reservoir models, HBV model, TOPMODEL, SHE model, etc. From the late 1980s, the evolution of global and continental-scale hydrology has placed new demands on hydrologic modellers. The macro-scale hydrological (global and regional scale) models were developed on the basis of the following motivations (Arenll, 1999). First, for a variety of operational and planning purposes, water resource managers responsible for large regions need to estimate the spatial variability of resources over large areas, at a spatial resolution finer than can be provided by observed data alone. Second, hydrologists and water managers are interested in the effects of land-use and climate variability and change over a large geographic domain. Third, there is an increasing need of using hydrologic models as a base to estimate point and non-point sources of pollution loading to streams. Fourth, hydrologists and atmospheric modellers have perceived weaknesses in the representation of hydrological processes in regional and global climate models, and developed global hydrological models to overcome the weaknesses of global climate models. Considerable progress in the development and application of global hydrological models has been achieved to date, however, large uncertainties still exist considering the model structure including large scale flow routing, parameterization, input data, etc. This presentation will focus on the global hydrological models, and the discussion includes (1) types of global hydrological models, (2) procedure of global hydrological model development

  17. From Numeric Models to Granular System Modeling

    Directory of Open Access Journals (Sweden)

    Witold Pedrycz

    2015-03-01

    To make this study self-contained, we briefly recall the key concepts of granular computing and demonstrate how this conceptual framework and its algorithmic fundamentals give rise to granular models. We discuss several representative formal setups used in describing and processing information granules including fuzzy sets, rough sets, and interval calculus. Key architectures of models dwell upon relationships among information granules. We demonstrate how information granularity and its optimization can be regarded as an important design asset to be exploited in system modeling and giving rise to granular models. With this regard, an important category of rule-based models along with their granular enrichments is studied in detail.

  18. Geologic Framework Model Analysis Model Report

    Energy Technology Data Exchange (ETDEWEB)

    R. Clayton

    2000-12-19

    The purpose of this report is to document the Geologic Framework Model (GFM), Version 3.1 (GFM3.1) with regard to data input, modeling methods, assumptions, uncertainties, limitations, and validation of the model results, qualification status of the model, and the differences between Version 3.1 and previous versions. The GFM represents a three-dimensional interpretation of the stratigraphy and structural features of the location of the potential Yucca Mountain radioactive waste repository. The GFM encompasses an area of 65 square miles (170 square kilometers) and a volume of 185 cubic miles (771 cubic kilometers). The boundaries of the GFM were chosen to encompass the most widely distributed set of exploratory boreholes (the Water Table or WT series) and to provide a geologic framework over the area of interest for hydrologic flow and radionuclide transport modeling through the unsaturated zone (UZ). The depth of the model is constrained by the inferred depth of the Tertiary-Paleozoic unconformity. The GFM was constructed from geologic map and borehole data. Additional information from measured stratigraphy sections, gravity profiles, and seismic profiles was also considered. This interim change notice (ICN) was prepared in accordance with the Technical Work Plan for the Integrated Site Model Process Model Report Revision 01 (CRWMS M&O 2000). The constraints, caveats, and limitations associated with this model are discussed in the appropriate text sections that follow. The GFM is one component of the Integrated Site Model (ISM) (Figure l), which has been developed to provide a consistent volumetric portrayal of the rock layers, rock properties, and mineralogy of the Yucca Mountain site. The ISM consists of three components: (1) Geologic Framework Model (GFM); (2) Rock Properties Model (RPM); and (3) Mineralogic Model (MM). The ISM merges the detailed project stratigraphy into model stratigraphic units that are most useful for the primary downstream models and the

  19. Model Theory and Applications

    CERN Document Server

    Mangani, P

    2011-01-01

    This title includes: Lectures - G.E. Sacks - Model theory and applications, and H.J. Keisler - Constructions in model theory; and, Seminars - M. Servi - SH formulas and generalized exponential, and J.A. Makowski - Topological model theory.

  20. Wildfire Risk Main Model

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — The model combines three modeled fire behavior parameters (rate of spread, flame length, crown fire potential) and one modeled ecological health measure (fire regime...

  1. Computational neurogenetic modeling

    CERN Document Server

    Benuskova, Lubica

    2010-01-01

    Computational Neurogenetic Modeling is a student text, introducing the scope and problems of a new scientific discipline - Computational Neurogenetic Modeling (CNGM). CNGM is concerned with the study and development of dynamic neuronal models for modeling brain functions with respect to genes and dynamic interactions between genes. These include neural network models and their integration with gene network models. This new area brings together knowledge from various scientific disciplines, such as computer and information science, neuroscience and cognitive science, genetics and molecular biol

  2. Predictive Models for Music

    OpenAIRE

    Paiement, Jean-François; Grandvalet, Yves; Bengio, Samy

    2008-01-01

    Modeling long-term dependencies in time series has proved very difficult to achieve with traditional machine learning methods. This problem occurs when considering music data. In this paper, we introduce generative models for melodies. We decompose melodic modeling into two subtasks. We first propose a rhythm model based on the distributions of distances between subsequences. Then, we define a generative model for melodies given chords and rhythms based on modeling sequences of Narmour featur...

  3. OH observations in a tropical rain forest environment using a chemical ionization mass spectrometry technique during GOAmazon intensive campaigns

    Science.gov (United States)

    Kim, S.; Seco, R.; Park, J. H.; Sjostedt, S. J.; Guenther, A. B.; Smith, J. N.; Liu, Y.; Bustillos, J. O. V.; Souza, R. A. F. D.; Tota, J.; Martin, S. T.

    2015-12-01

    We will present observed OH in the Amazon rain forest using a chemical ionization mass spectrometer (CIMS). The observation was conducted at the T3 site in Manacapuru, Amazonas Brazil. It had been accepted almost as an axiom that very low OH is expected in low NO environments such as a pristine rain forest. However, recent studies in the pristine rain forest environments consistently reported significantly higher than expected OH levels. This sparked extensive and intensive studies to explore any possibility of OH regeneration from isoprene photo-oxidation processes in the low NO condition. Four OH regeneration processes related with isoprene photochemistry have been proposed since 2008. However, the levels of the expected OH enhancement vary greatly among the proposed OH regeneration processes mediated by the isoprene oxidation processes. As all enhanced OH observations from the pristine areas with high isoprene conditions have used the laser induced fluorescence (LIF) technique, the possibilities of potential positive artifacts have also been explored. In this context, the first tropical forest CIMS OH dataset will be discussed in the context of 1) comparisons with previously reported OH using the LIF technique, 2) comparisons with box model calculated OH with different isoprene oxidation scenarios to reconcile measured and calculated OH, and 3) comparisons with regional model calculated OH. The CIMS observational dataset along with a comprehensive trace gas dataset provides a constraint to assess current uncertainty in oxidation capacity of the pristine forested region, which has tremendous implications towards global fates of short lived climate forcers.

  4. Affinity selection of histidine-containing peptides using metal chelate methacrylate monolithic disk for targeted LC-MS/MS approach in high-throughput proteomics.

    Science.gov (United States)

    Prasanna, Rajasekar R; Sidhik, Sinash; Kamalanathan, Agamudi S; Bhagavatula, Krishna; Vijayalakshmi, Mookambeswaran A

    2014-04-01

    In recent years, bottom-up approach has become the popular method of choice for large scale analysis of complex proteome samples. Peptide fractionation determines the efficiency of the bottom-up method and often the resolving power of reverse phase liquid chromatography (RPLC) is insufficient for efficient protein identification in case of complex biological samples. To overcome the inherent limitation of proteomics associated with sample complexity, we evaluated fast flow metal chelate methacrylate monolithic system - CIM (Convective Interaction Media) disk chelated with Cu(II) for targeted affinity selection of histidine-containing peptides. Initially the Cu(II)-IMAC using CIM disk was evaluated using tryptic digest of protein mixtures of 8 model proteins and was found to be highly efficient in capturing His-containing peptides with high degree of specificity and selectivity. Further the efficiency of His-peptide enrichment using CIM-IMAC was also demonstrated using complex biological samples like total Escherichia coli cell lysate. The analysis of the Cu(II)-IMAC retained peptides from tryptic digests of model protein mixture and E. coli not only demonstrated a significant reduction in sample complexity but also subsequently enabled the identification of additional peptides. His-peptide enrichment also enabled the identification of low abundant proteins that were not detected in the analysis of total E. coli digest.

  5. TRACKING CLIMATE MODELS

    Data.gov (United States)

    National Aeronautics and Space Administration — CLAIRE MONTELEONI*, GAVIN SCHMIDT, AND SHAILESH SAROHA* Climate models are complex mathematical models designed by meteorologists, geophysicists, and climate...

  6. Environmental Modeling Center

    Data.gov (United States)

    Federal Laboratory Consortium — The Environmental Modeling Center provides the computational tools to perform geostatistical analysis, to model ground water and atmospheric releases for comparison...

  7. Continuous system modeling

    Science.gov (United States)

    Cellier, Francois E.

    1991-01-01

    A comprehensive and systematic introduction is presented for the concepts associated with 'modeling', involving the transition from a physical system down to an abstract description of that system in the form of a set of differential and/or difference equations, and basing its treatment of modeling on the mathematics of dynamical systems. Attention is given to the principles of passive electrical circuit modeling, planar mechanical systems modeling, hierarchical modular modeling of continuous systems, and bond-graph modeling. Also discussed are modeling in equilibrium thermodynamics, population dynamics, and system dynamics, inductive reasoning, artificial neural networks, and automated model synthesis.

  8. Global Business Models

    DEFF Research Database (Denmark)

    Rask, Morten

    insight from the literature about business models, international product policy, international entry modes and globalization into a conceptual model of relevant design elements of global business models, enabling global business model innovation to deal with differences in a downstream perspective...... regarding the customer interface and in an upstream perspective regarding the supply infrastructure. The paper offers a coherent conceptual dynamic meta-model of global business model innovation. Students, scholars and managers within the field of international business can use this conceptualization...... to understand, to study, and to create global business model innovation. Managerial and research implications draw on the developed ideal type of global business model innovation....

  9. Understandings of 'Modelling'

    DEFF Research Database (Denmark)

    Andresen, Mette

    2007-01-01

    This paper meets the common critique of the teaching of non-authentic modelling in school mathematics. In the paper, non-authentic modelling is related to a change of view on the intentions of modelling from knowledge about applications of mathematical models to modelling for concept formation. Non......-authentic modelling is also linked with the potentials of exploration of ready-made models as a forerunner for more authentic modelling processes. The discussion includes analysis of an episode of students? work in the classroom, which serves to illustrate how concept formation may be linked to explorations of a non...

  10. Combustion modeling in a model combustor

    Institute of Scientific and Technical Information of China (English)

    L.Y.Jiang; I.Campbell; K.Su

    2007-01-01

    The flow-field of a propane-air diffusion flame combustor with interior and exterior conjugate heat transfers was numerically studied.Results obtained from four combustion models,combined with the re-normalization group (RNG) k-ε turbulence model,discrete ordinates radiation model and enhanced wall treatment are presented and discussed.The results are compared with a comprehensive database obtained from a series of experimental measurements.The flow patterns and the recirculation zone length in the combustion chamber are accurately predicted,and the mean axial velocities are in fairly good agreement with the experimental data,particularly at downstream sections for all four combustion models.The mean temperature profiles are captured fairly well by the eddy dissipation (EDS),probability density function (PDF),and laminar flamelet combustion models.However,the EDS-finite-rate combustion model fails to provide an acceptable temperature field.In general,the flamelet model illustrates little superiority over the PDF model,and to some extent the PDF model shows better performance than the EDS model.

  11. Interfacing materials models with fire field models

    Energy Technology Data Exchange (ETDEWEB)

    Nicolette, V.F.; Tieszen, S.R.; Moya, J.L.

    1995-12-01

    For flame spread over solid materials, there has traditionally been a large technology gap between fundamental combustion research and the somewhat simplistic approaches used for practical, real-world applications. Recent advances in computational hardware and computational fluid dynamics (CFD)-based software have led to the development of fire field models. These models, when used in conjunction with material burning models, have the potential to bridge the gap between research and application by implementing physics-based engineering models in a transient, multi-dimensional tool. This paper discusses the coupling that is necessary between fire field models and burning material models for the simulation of solid material fires. Fire field models are capable of providing detailed information about the local fire environment. This information serves as an input to the solid material combustion submodel, which subsequently calculates the impact of the fire environment on the material. The response of the solid material (in terms of thermal response, decomposition, charring, and off-gassing) is then fed back into the field model as a source of mass, momentum and energy. The critical parameters which must be passed between the field model and the material burning model have been identified. Many computational issues must be addressed when developing such an interface. Some examples include the ability to track multiple fuels and species, local ignition criteria, and the need to use local grid refinement over the burning material of interest.

  12. Regularized Structural Equation Modeling.

    Science.gov (United States)

    Jacobucci, Ross; Grimm, Kevin J; McArdle, John J

    A new method is proposed that extends the use of regularization in both lasso and ridge regression to structural equation models. The method is termed regularized structural equation modeling (RegSEM). RegSEM penalizes specific parameters in structural equation models, with the goal of creating easier to understand and simpler models. Although regularization has gained wide adoption in regression, very little has transferred to models with latent variables. By adding penalties to specific parameters in a structural equation model, researchers have a high level of flexibility in reducing model complexity, overcoming poor fitting models, and the creation of models that are more likely to generalize to new samples. The proposed method was evaluated through a simulation study, two illustrative examples involving a measurement model, and one empirical example involving the structural part of the model to demonstrate RegSEM's utility.

  13. ROCK PROPERTIES MODEL ANALYSIS MODEL REPORT

    Energy Technology Data Exchange (ETDEWEB)

    Clinton Lum

    2002-02-04

    The purpose of this Analysis and Model Report (AMR) is to document Rock Properties Model (RPM) 3.1 with regard to input data, model methods, assumptions, uncertainties and limitations of model results, and qualification status of the model. The report also documents the differences between the current and previous versions and validation of the model. The rock properties models are intended principally for use as input to numerical physical-process modeling, such as of ground-water flow and/or radionuclide transport. The constraints, caveats, and limitations associated with this model are discussed in the appropriate text sections that follow. This work was conducted in accordance with the following planning documents: WA-0344, ''3-D Rock Properties Modeling for FY 1998'' (SNL 1997, WA-0358), ''3-D Rock Properties Modeling for FY 1999'' (SNL 1999), and the technical development plan, Rock Properties Model Version 3.1, (CRWMS M&O 1999c). The Interim Change Notice (ICNs), ICN 02 and ICN 03, of this AMR were prepared as part of activities being conducted under the Technical Work Plan, TWP-NBS-GS-000003, ''Technical Work Plan for the Integrated Site Model, Process Model Report, Revision 01'' (CRWMS M&O 2000b). The purpose of ICN 03 is to record changes in data input status due to data qualification and verification activities. These work plans describe the scope, objectives, tasks, methodology, and implementing procedures for model construction. The constraints, caveats, and limitations associated with this model are discussed in the appropriate text sections that follow. The work scope for this activity consists of the following: (1) Conversion of the input data (laboratory measured porosity data, x-ray diffraction mineralogy, petrophysical calculations of bound water, and petrophysical calculations of porosity) for each borehole into stratigraphic coordinates; (2) Re-sampling and merging of data sets; (3

  14. Model Reduction of Nonlinear Fire Dynamics Models

    OpenAIRE

    Lattimer, Alan Martin

    2016-01-01

    Due to the complexity, multi-scale, and multi-physics nature of the mathematical models for fires, current numerical models require too much computational effort to be useful in design and real-time decision making, especially when dealing with fires over large domains. To reduce the computational time while retaining the complexity of the domain and physics, our research has focused on several reduced-order modeling techniques. Our contributions are improving wildland fire reduced-order mod...

  15. Better models are more effectively connected models

    Science.gov (United States)

    Nunes, João Pedro; Bielders, Charles; Darboux, Frederic; Fiener, Peter; Finger, David; Turnbull-Lloyd, Laura; Wainwright, John

    2016-04-01

    The concept of hydrologic and geomorphologic connectivity describes the processes and pathways which link sources (e.g. rainfall, snow and ice melt, springs, eroded areas and barren lands) to accumulation areas (e.g. foot slopes, streams, aquifers, reservoirs), and the spatial variations thereof. There are many examples of hydrological and sediment connectivity on a watershed scale; in consequence, a process-based understanding of connectivity is crucial to help managers understand their systems and adopt adequate measures for flood prevention, pollution mitigation and soil protection, among others. Modelling is often used as a tool to understand and predict fluxes within a catchment by complementing observations with model results. Catchment models should therefore be able to reproduce the linkages, and thus the connectivity of water and sediment fluxes within the systems under simulation. In modelling, a high level of spatial and temporal detail is desirable to ensure taking into account a maximum number of components, which then enables connectivity to emerge from the simulated structures and functions. However, computational constraints and, in many cases, lack of data prevent the representation of all relevant processes and spatial/temporal variability in most models. In most cases, therefore, the level of detail selected for modelling is too coarse to represent the system in a way in which connectivity can emerge; a problem which can be circumvented by representing fine-scale structures and processes within coarser scale models using a variety of approaches. This poster focuses on the results of ongoing discussions on modelling connectivity held during several workshops within COST Action Connecteur. It assesses the current state of the art of incorporating the concept of connectivity in hydrological and sediment models, as well as the attitudes of modellers towards this issue. The discussion will focus on the different approaches through which connectivity

  16. Multiple Model Approaches to Modelling and Control,

    DEFF Research Database (Denmark)

    on the ease with which prior knowledge can be incorporated. It is interesting to note that researchers in Control Theory, Neural Networks,Statistics, Artificial Intelligence and Fuzzy Logic have more or less independently developed very similar modelling methods, calling them Local ModelNetworks, Operating...... of introduction of existing knowledge, as well as the ease of model interpretation. This book attempts to outlinemuch of the common ground between the various approaches, encouraging the transfer of ideas.Recent progress in algorithms and analysis is presented, with constructive algorithms for automated model...

  17. Multivariate GARCH models

    DEFF Research Database (Denmark)

    Silvennoinen, Annastiina; Teräsvirta, Timo

    This article contains a review of multivariate GARCH models. Most common GARCH models are presented and their properties considered. This also includes nonparametric and semiparametric models. Existing specification and misspecification tests are discussed. Finally, there is an empirical example...... in which several multivariate GARCH models are fitted to the same data set and the results compared....

  18. The 5C Model

    DEFF Research Database (Denmark)

    Friis, Silje Alberthe Kamille; Gelting, Anne Katrine Gøtzsche

    2014-01-01

    the approaches and reach a new level of conscious action when designing? Informed by theories of design thinking, knowledge production, and learning, we have developed a model, the 5C model, accompanied by 62 method cards. Examples of how the model has been applied in an educational setting are provided......, explaining how and why the model and method cards work in practice....

  19. AIDS Epidemiological models

    Science.gov (United States)

    Rahmani, Fouad Lazhar

    2010-11-01

    The aim of this paper is to present mathematical modelling of the spread of infection in the context of the transmission of the human immunodeficiency virus (HIV) and the acquired immune deficiency syndrome (AIDS). These models are based in part on the models suggested in the field of th AIDS mathematical modelling as reported by ISHAM [6].

  20. Lumped-parameter models

    Energy Technology Data Exchange (ETDEWEB)

    Ibsen, Lars Bo; Liingaard, M.

    2006-12-15

    A lumped-parameter model represents the frequency dependent soil-structure interaction of a massless foundation placed on or embedded into an unbounded soil domain. In this technical report the steps of establishing a lumped-parameter model are presented. Following sections are included in this report: Static and dynamic formulation, Simple lumped-parameter models and Advanced lumped-parameter models. (au)

  1. Biomass Scenario Model

    Energy Technology Data Exchange (ETDEWEB)

    2015-09-01

    The Biomass Scenario Model (BSM) is a unique, carefully validated, state-of-the-art dynamic model of the domestic biofuels supply chain which explicitly focuses on policy issues, their feasibility, and potential side effects. It integrates resource availability, physical/technological/economic constraints, behavior, and policy. The model uses a system dynamics simulation (not optimization) to model dynamic interactions across the supply chain.

  2. Dynamic Latent Classification Model

    DEFF Research Database (Denmark)

    Zhong, Shengtong; Martínez, Ana M.; Nielsen, Thomas Dyhre

    as possible. Motivated by this problem setting, we propose a generative model for dynamic classification in continuous domains. At each time point the model can be seen as combining a naive Bayes model with a mixture of factor analyzers (FA). The latent variables of the FA are used to capture the dynamics...... in the process as well as modeling dependences between attributes....

  3. Modelling Railway Interlocking Systems

    DEFF Research Database (Denmark)

    Lindegaard, Morten Peter; Viuf, P.; Haxthausen, Anne Elisabeth

    2000-01-01

    In this report we present a model of interlocking systems, and describe how the model may be validated by simulation. Station topologies are modelled by graphs in which the nodes denote track segments, and the edges denote connectivity for train traÆc. Points and signals are modelled by annotatio...

  4. Multilevel IRT Model Assessment

    NARCIS (Netherlands)

    Fox, Jean-Paul; Ark, L. Andries; Croon, Marcel A.

    2005-01-01

    Modelling complex cognitive and psychological outcomes in, for example, educational assessment led to the development of generalized item response theory (IRT) models. A class of models was developed to solve practical and challenging educational problems by generalizing the basic IRT models. An IRT

  5. Generic Market Models

    NARCIS (Netherlands)

    R. Pietersz (Raoul); M. van Regenmortel

    2005-01-01

    textabstractCurrently, there are two market models for valuation and risk management of interest rate derivatives, the LIBOR and swap market models. In this paper, we introduce arbitrage-free constant maturity swap (CMS) market models and generic market models featuring forward rates that span perio

  6. Numerical Modelling of Streams

    DEFF Research Database (Denmark)

    Vestergaard, Kristian

    In recent years there has been a sharp increase in the use of numerical water quality models. Numeric water quality modeling can be divided into three steps: Hydrodynamic modeling for the determination of stream flow and water levels. Modelling of transport and dispersion of a conservative...

  7. Talk about toy models

    Science.gov (United States)

    Luczak, Joshua

    2017-02-01

    Scientific models are frequently discussed in philosophy of science. A great deal of the discussion is centred on approximation, idealisation, and on how these models achieve their representational function. Despite the importance, distinct nature, and high presence of toy models, they have received little attention from philosophers. This paper hopes to remedy this situation. It aims to elevate the status of toy models: by distinguishing them from approximations and idealisations, by highlighting and elaborating on several ways the Kac ring, a simple statistical mechanical model, is used as a toy model, and by explaining why toy models can be used to successfully carry out important work without performing a representational function.

  8. Latent classification models

    DEFF Research Database (Denmark)

    Langseth, Helge; Nielsen, Thomas Dyhre

    2005-01-01

    One of the simplest, and yet most consistently well-performing setof classifiers is the \\NB models. These models rely on twoassumptions: $(i)$ All the attributes used to describe an instanceare conditionally independent given the class of that instance,and $(ii)$ all attributes follow a specific...... parametric family ofdistributions.  In this paper we propose a new set of models forclassification in continuous domains, termed latent classificationmodels. The latent classification model can roughly be seen ascombining the \\NB model with a mixture of factor analyzers,thereby relaxing the assumptions...... classification model, and wedemonstrate empirically that the accuracy of the proposed model issignificantly higher than the accuracy of other probabilisticclassifiers....

  9. A Model for Conversation

    DEFF Research Database (Denmark)

    Ayres, Phil

    2012-01-01

    This essay discusses models. It examines what models are, the roles models perform and suggests various intentions that underlie their construction and use. It discusses how models act as a conversational partner, and how they support various forms of conversation within the conversational activity...... of design. Three distinctions are drawn through which to develop this discussion of models in an architectural context. An examination of these distinctions serves to nuance particular characteristics and roles of models, the modelling activity itself and those engaged in it....

  10. Wastewater Treatment Models

    DEFF Research Database (Denmark)

    Gernaey, Krist; Sin, Gürkan

    2008-01-01

    The state-of-the-art level reached in modeling wastewater treatment plants (WWTPs) is reported. For suspended growth systems, WWTP models have evolved from simple description of biological removal of organic carbon and nitrogen in aeration tanks (ASM1 in 1987) to more advanced levels including...... the practice of WWTP modeling by linking the wastewater treatment line with the sludge handling line in one modeling platform. Application of WWTP models is currently rather time consuming and thus expensive due to the high model complexity, and requires a great deal of process knowledge and modeling expertise...

  11. Wastewater treatment models

    DEFF Research Database (Denmark)

    Gernaey, Krist; Sin, Gürkan

    2011-01-01

    The state-of-the-art level reached in modeling wastewater treatment plants (WWTPs) is reported. For suspended growth systems, WWTP models have evolved from simple description of biological removal of organic carbon and nitrogen in aeration tanks (ASM1 in 1987) to more advanced levels including...... of WWTP modeling by linking the wastewater treatment line with the sludge handling line in one modeling platform. Application of WWTP models is currently rather time consuming and thus expensive due to the high model complexity, and requires a great deal of process knowledge and modeling expertise...

  12. Lumped Thermal Household Model

    DEFF Research Database (Denmark)

    Biegel, Benjamin; Andersen, Palle; Stoustrup, Jakob

    2013-01-01

    a lumped model approach as an alternative to the individual models. In the lumped model, the portfolio is seen as baseline consumption superimposed with an ideal storage of limited power and energy capacity. The benefit of such a lumped model is that the computational effort of flexibility optimization......In this paper we discuss two different approaches to model the flexible power consumption of heat pump heated households: individual household modeling and lumped modeling. We illustrate that a benefit of individual modeling is that we can overview and optimize the complete flexibility of a heat...... pump portfolio. Following, we illustrate two disadvantages of individual models, namely that it requires much computational effort to optimize over a large portfolio, and second that it is difficult to accurately model the houses in certain time periods due to local disturbances. Finally, we propose...

  13. Nonuniform Markov models

    CERN Document Server

    Ristad, E S; Ristad, Eric Sven; Thomas, Robert G.

    1996-01-01

    A statistical language model assigns probability to strings of arbitrary length. Unfortunately, it is not possible to gather reliable statistics on strings of arbitrary length from a finite corpus. Therefore, a statistical language model must decide that each symbol in a string depends on at most a small, finite number of other symbols in the string. In this report we propose a new way to model conditional independence in Markov models. The central feature of our nonuniform Markov model is that it makes predictions of varying lengths using contexts of varying lengths. Experiments on the Wall Street Journal reveal that the nonuniform model performs slightly better than the classic interpolated Markov model. This result is somewhat remarkable because both models contain identical numbers of parameters whose values are estimated in a similar manner. The only difference between the two models is how they combine the statistics of longer and shorter strings. Keywords: nonuniform Markov model, interpolated Markov m...

  14. Protein Models Comparator

    CERN Document Server

    Widera, Paweł

    2011-01-01

    The process of comparison of computer generated protein structural models is an important element of protein structure prediction. It has many uses including model quality evaluation, selection of the final models from a large set of candidates or optimisation of parameters of energy functions used in template free modelling and refinement. Although many protein comparison methods are available online on numerous web servers, their ability to handle a large scale model comparison is often very limited. Most of the servers offer only a single pairwise structural comparison, and they usually do not provide a model-specific comparison with a fixed alignment between the models. To bridge the gap between the protein and model structure comparison we have developed the Protein Models Comparator (pm-cmp). To be able to deliver the scalability on demand and handle large comparison experiments the pm-cmp was implemented "in the cloud". Protein Models Comparator is a scalable web application for a fast distributed comp...

  15. Introduction to Adjoint Models

    Science.gov (United States)

    Errico, Ronald M.

    2015-01-01

    In this lecture, some fundamentals of adjoint models will be described. This includes a basic derivation of tangent linear and corresponding adjoint models from a parent nonlinear model, the interpretation of adjoint-derived sensitivity fields, a description of methods of automatic differentiation, and the use of adjoint models to solve various optimization problems, including singular vectors. Concluding remarks will attempt to correct common misconceptions about adjoint models and their utilization.

  16. An enhanced communication model

    OpenAIRE

    Flensburg, Per

    2010-01-01

    The concept of information is often taken for more or less granted in research about information systems. This paper introduces a model starting with Shannon and Weaver data transmission model and ends with knowledge transfer between individual persons. The model is in fact an enhanced communication model giving a framework for discussing problems in the communication process. A specific feature of the model is the aim for providing design guidelines in designing the communication process. Th...

  17. Modeling cholera outbreaks

    OpenAIRE

    Dennis L Chao; Longini, Ira M.; Morris, J. Glenn

    2014-01-01

    Mathematical modeling can be a valuable tool for studying infectious disease outbreak dynamics and simulating the effects of possible interventions. Here, we describe approaches to modeling cholera outbreaks and how models have been applied to explore intervention strategies, particularly in Haiti. Mathematical models can play an important role in formulating and evaluating complex cholera outbreak response options. Major challenges to cholera modeling are insufficient data for calibrating mo...

  18. Model Checking of Boolean Process Models

    CERN Document Server

    Schneider, Christoph

    2011-01-01

    In the field of Business Process Management formal models for the control flow of business processes have been designed since more than 15 years. Which methods are best suited to verify the bulk of these models? The first step is to select a formal language which fixes the semantics of the models. We adopt the language of Boolean systems as reference language for Boolean process models. Boolean systems form a simple subclass of coloured Petri nets. Their characteristics are low tokens to model explicitly states with a subsequent skipping of activations and arbitrary logical rules of type AND, XOR, OR etc. to model the split and join of the control flow. We apply model checking as a verification method for the safeness and liveness of Boolean systems. Model checking of Boolean systems uses the elementary theory of propositional logic, no modal operators are needed. Our verification builds on a finite complete prefix of a certain T-system attached to the Boolean system. It splits the processes of the Boolean sy...

  19. Mechanical signaling in the pathophysiology of critical illness myopathy

    Directory of Open Access Journals (Sweden)

    Rebeca Corpeño Kalamgi

    2016-02-01

    Full Text Available The complete loss of mechanical stimuli of skeletal muscles, i.e., the loss of external strain, related to weight bearing, and internal strain, related to the contraction of muscle cells, is uniquely observed in pharmacologically paralyzed or deeply sedated mechanically ventilated intensive care unit (ICU patients. The preferential loss of myosin and myosin associated proteins in limb and trunk muscles is a significant characteristic of critical illness myopathy (CIM which separates CIM from other types of acquired muscle weaknesses in ICU patients. Mechanical silencing is an important factor triggering CIM. Microgravity or ground based microgravity models form the basis of research on the effect of muscle unloading-reloading, but the mechanisms and effects may differ from the ICU conditions. In order to understand how mechanical tension regulates muscle mass, it is critical to know how muscles sense mechanical information and convert stimulus to intracellular biochemical actions and changes in gene expression, a process called cellular mechanotransduction. In adult skeletal muscles and muscle fibers, this process may differ, the same stimulus can cause divergent response and the same fiber type may undergo opposite changes in different muscles. Skeletal muscle contains multiple types of mechano-sensors and numerous structures that can be affected differently and hence respond differently in distinct muscles

  20. Software Technology for Adaptable, Reliable Systems (STARS) Program

    Science.gov (United States)

    1994-07-25

    using IDEFIx notation. This high-level model was developed based on the information flow depicted in the activity model and independently to the ERD...The ERD model was compared against both the entities defined in the 00 model and the CIM IDEFix data model to ensure consistency. Although each of the...Space Model &hsPro Proe/t O •AppliatIo n Gene erin MOIA, IDEFIX utL antn e ei e hay e s e f he E r n M S Engineeapliaton-evl"odes.n.upprtofAppic

  1. Flexible survival regression modelling

    DEFF Research Database (Denmark)

    Cortese, Giuliana; Scheike, Thomas H; Martinussen, Torben

    2009-01-01

    Regression analysis of survival data, and more generally event history data, is typically based on Cox's regression model. We here review some recent methodology, focusing on the limitations of Cox's regression model. The key limitation is that the model is not well suited to represent time......-varying effects. We start by considering classical and also more recent goodness-of-fit procedures for the Cox model that will reveal when the Cox model does not capture important aspects of the data, such as time-varying effects. We present recent regression models that are able to deal with and describe...... such time-varying effects. The introduced models are all applied to data on breast cancer from the Norwegian cancer registry, and these analyses clearly reveal the shortcomings of Cox's regression model and the need for other supplementary analyses with models such as those we present here....

  2. Model Validation Status Review

    Energy Technology Data Exchange (ETDEWEB)

    E.L. Hardin

    2001-11-28

    The primary objective for the Model Validation Status Review was to perform a one-time evaluation of model validation associated with the analysis/model reports (AMRs) containing model input to total-system performance assessment (TSPA) for the Yucca Mountain site recommendation (SR). This review was performed in response to Corrective Action Request BSC-01-C-01 (Clark 2001, Krisha 2001) pursuant to Quality Assurance review findings of an adverse trend in model validation deficiency. The review findings in this report provide the following information which defines the extent of model validation deficiency and the corrective action needed: (1) AMRs that contain or support models are identified, and conversely, for each model the supporting documentation is identified. (2) The use for each model is determined based on whether the output is used directly for TSPA-SR, or for screening (exclusion) of features, events, and processes (FEPs), and the nature of the model output. (3) Two approaches are used to evaluate the extent to which the validation for each model is compliant with AP-3.10Q (Analyses and Models). The approaches differ in regard to whether model validation is achieved within individual AMRs as originally intended, or whether model validation could be readily achieved by incorporating information from other sources. (4) Recommendations are presented for changes to the AMRs, and additional model development activities or data collection, that will remedy model validation review findings, in support of licensing activities. The Model Validation Status Review emphasized those AMRs that support TSPA-SR (CRWMS M&O 2000bl and 2000bm). A series of workshops and teleconferences was held to discuss and integrate the review findings. The review encompassed 125 AMRs (Table 1) plus certain other supporting documents and data needed to assess model validity. The AMRs were grouped in 21 model areas representing the modeling of processes affecting the natural and

  3. Practical Marginalized Multilevel Models.

    Science.gov (United States)

    Griswold, Michael E; Swihart, Bruce J; Caffo, Brian S; Zeger, Scott L

    2013-01-01

    Clustered data analysis is characterized by the need to describe both systematic variation in a mean model and cluster-dependent random variation in an association model. Marginalized multilevel models embrace the robustness and interpretations of a marginal mean model, while retaining the likelihood inference capabilities and flexible dependence structures of a conditional association model. Although there has been increasing recognition of the attractiveness of marginalized multilevel models, there has been a gap in their practical application arising from a lack of readily available estimation procedures. We extend the marginalized multilevel model to allow for nonlinear functions in both the mean and association aspects. We then formulate marginal models through conditional specifications to facilitate estimation with mixed model computational solutions already in place. We illustrate the MMM and approximate MMM approaches on a cerebrovascular deficiency crossover trial using SAS and an epidemiological study on race and visual impairment using R. Datasets, SAS and R code are included as supplemental materials.

  4. Effect of prenatal and postnatal exposure to therapeutic doses of chlorimipramine on emotionality in the rat.

    Science.gov (United States)

    Rodríguez Echandía, E L; Broitman, S T

    1983-01-01

    Prenatal administration of high doses of tricyclic antidepressants have been reported to produce teratogenic and behavioral effects in rat offspring. In the present work, behavioral abnormalities are described in offspring of rats treated with therapeutic doses of chlorimipramine (CIM) during pregnancy (CIM-P), lactation (CIM-L) and during the whole pregnancy-lactation period (CIM-PL). CIM-P treatment did not produce teratogenic effects, did not affect number or body weight of pups at birth and did not induce neonatal mortality. At 2 months of age, the CIM-P males showed a significant increase in digging and grooming (familiar environment test), a decrease in "exploration" (novel environment test) and a decrease in active social interactions (social behavior test). Females were more resistant than males to the prenatal CIM treatment. The results suggest increased emotionality in CIM-P pups. Some behavioral abnormalities were also observed in the tests performed at 4 months of age. CIM-L treatment had minor effects on litter behavior. CIM-PL treatment potentiated the effects of the CIM-P treatment. In the CIM-PL males, impairment of exploration of a novel environment still remained in the tests performed at 4 months of age. It is speculated that when prenatal brain development is altered by CIM, further postnatal treatment may impair compensatory processes occurring in early postnatal life.

  5. Modeling worldwide highway networks

    Science.gov (United States)

    Villas Boas, Paulino R.; Rodrigues, Francisco A.; da F. Costa, Luciano

    2009-12-01

    This Letter addresses the problem of modeling the highway systems of different countries by using complex networks formalism. More specifically, we compare two traditional geographical models with a modified geometrical network model where paths, rather than edges, are incorporated at each step between the origin and the destination vertices. Optimal configurations of parameters are obtained for each model and used for the comparison. The highway networks of Australia, Brazil, India, and Romania are considered and shown to be properly modeled by the modified geographical model.

  6. Microsoft tabular modeling cookbook

    CERN Document Server

    Braak, Paul te

    2013-01-01

    This book follows a cookbook style with recipes explaining the steps for developing analytic data using Business Intelligence Semantic Models.This book is designed for developers who wish to develop powerful and dynamic models for users as well as those who are responsible for the administration of models in corporate environments. It is also targeted at analysts and users of Excel who wish to advance their knowledge of Excel through the development of tabular models or who wish to analyze data through tabular modeling techniques. We assume no prior knowledge of tabular modeling

  7. On Communication Models

    Institute of Scientific and Technical Information of China (English)

    蒋娜; 谢有琪

    2012-01-01

    With the development of human society, the social hub enlarges beyond one community to the extent that the world is deemed as a community as a whole. Communication, therefore, plays an increasingly important role in our daily life. As a consequence, communication model or the definition of which is not so much a definition as a guide in communication. However, some existed communication models are not as practical as it was. This paper tries to make an overall contrast among three communication models Coded Model, Gable Communication Model and Ostensive Inferential Model, to see how they assist people to comprehend verbal and non -verbal communication.

  8. Five models of capitalism

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Bresser-Pereira

    2012-03-01

    Full Text Available Besides analyzing capitalist societies historically and thinking of them in terms of phases or stages, we may compare different models or varieties of capitalism. In this paper I survey the literature on this subject, and distinguish the classification that has a production or business approach from those that use a mainly political criterion. I identify five forms of capitalism: among the rich countries, the liberal democratic or Anglo-Saxon model, the social or European model, and the endogenous social integration or Japanese model; among developing countries, I distinguish the Asian developmental model from the liberal-dependent model that characterizes most other developing countries, including Brazil.

  9. THE IMPROVED XINANJIANG MODEL

    Institute of Scientific and Technical Information of China (English)

    LI Zhi-jia; YAO Cheng; KONG Xiang-guang

    2005-01-01

    To improve the Xinanjiang model, the runoff generating from infiltration-excess is added to the model.The another 6 parameters are added to Xinanjiang model.In principle, the improved Xinanjiang model can be used to simulate runoff in the humid, semi-humid and also semi-arid regions.The application in Yi River shows the improved Xinanjiang model could forecast discharge with higher accuracy and can satisfy the practical requirements.It also shows that the improved model is reasonable.

  10. Energy-consumption modelling

    Energy Technology Data Exchange (ETDEWEB)

    Reiter, E.R.

    1980-01-01

    A highly sophisticated and accurate approach is described to compute on an hourly or daily basis the energy consumption for space heating by individual buildings, urban sectors, and whole cities. The need for models and specifically weather-sensitive models, composite models, and space-heating models are discussed. Development of the Colorado State University Model, based on heat-transfer equations and on a heuristic, adaptive, self-organizing computation learning approach, is described. Results of modeling energy consumption by the city of Minneapolis and Cheyenne are given. Some data on energy consumption in individual buildings are included.

  11. Holographic twin Higgs model.

    Science.gov (United States)

    Geller, Michael; Telem, Ofri

    2015-05-15

    We present the first realization of a "twin Higgs" model as a holographic composite Higgs model. Uniquely among composite Higgs models, the Higgs potential is protected by a new standard model (SM) singlet elementary "mirror" sector at the sigma model scale f and not by the composite states at m_{KK}, naturally allowing for m_{KK} beyond the LHC reach. As a result, naturalness in our model cannot be constrained by the LHC, but may be probed by precision Higgs measurements at future lepton colliders, and by direct searches for Kaluza-Klein excitations at a 100 TeV collider.

  12. Empirical Model Building Data, Models, and Reality

    CERN Document Server

    Thompson, James R

    2011-01-01

    Praise for the First Edition "This...novel and highly stimulating book, which emphasizes solving real problems...should be widely read. It will have a positive and lasting effect on the teaching of modeling and statistics in general." - Short Book Reviews This new edition features developments and real-world examples that showcase essential empirical modeling techniques Successful empirical model building is founded on the relationship between data and approximate representations of the real systems that generated that data. As a result, it is essential for researchers who construct these m

  13. Major Differences between the Jerome Model and the Horace Model

    Institute of Scientific and Technical Information of China (English)

    朱艳

    2014-01-01

    There are three famous translation models in the field of translation: the Jerome model, the Horace model and the Schleiermacher model. The production and development of the three models have significant influence on the translation. To find the major differences between the two western classical translation theoretical models, we discuss the Jerome model and the Hor-ace model deeply in this paper.

  14. Biosphere Model Report

    Energy Technology Data Exchange (ETDEWEB)

    D.W. Wu; A.J. Smith

    2004-11-08

    The purpose of this report is to document the biosphere model, the Environmental Radiation Model for Yucca Mountain, Nevada (ERMYN), which describes radionuclide transport processes in the biosphere and associated human exposure that may arise as the result of radionuclide release from the geologic repository at Yucca Mountain. The biosphere model is one of the process models that support the Yucca Mountain Project (YMP) Total System Performance Assessment (TSPA) for the license application (LA), TSPA-LA. The ERMYN provides the capability of performing human radiation dose assessments. This report documents the biosphere model, which includes: (1) Describing the reference biosphere, human receptor, exposure scenarios, and primary radionuclides for each exposure scenario (Section 6.1); (2) Developing a biosphere conceptual model using site-specific features, events, and processes (FEPs) (Section 6.2), the reference biosphere (Section 6.1.1), the human receptor (Section 6.1.2), and approximations (Sections 6.3.1.4 and 6.3.2.4); (3) Building a mathematical model using the biosphere conceptual model (Section 6.3) and published biosphere models (Sections 6.4 and 6.5); (4) Summarizing input parameters for the mathematical model, including the uncertainty associated with input values (Section 6.6); (5) Identifying improvements in the ERMYN compared with the model used in previous biosphere modeling (Section 6.7); (6) Constructing an ERMYN implementation tool (model) based on the biosphere mathematical model using GoldSim stochastic simulation software (Sections 6.8 and 6.9); (7) Verifying the ERMYN by comparing output from the software with hand calculations to ensure that the GoldSim implementation is correct (Section 6.10); (8) Validating the ERMYN by corroborating it with published biosphere models; comparing conceptual models, mathematical models, and numerical results (Section 7).

  15. Develop a Model Component

    Science.gov (United States)

    Ensey, Tyler S.

    2013-01-01

    During my internship at NASA, I was a model developer for Ground Support Equipment (GSE). The purpose of a model developer is to develop and unit test model component libraries (fluid, electrical, gas, etc.). The models are designed to simulate software for GSE (Ground Special Power, Crew Access Arm, Cryo, Fire and Leak Detection System, Environmental Control System (ECS), etc. .) before they are implemented into hardware. These models support verifying local control and remote software for End-Item Software Under Test (SUT). The model simulates the physical behavior (function, state, limits and 110) of each end-item and it's dependencies as defined in the Subsystem Interface Table, Software Requirements & Design Specification (SRDS), Ground Integrated Schematic (GIS), and System Mechanical Schematic.(SMS). The software of each specific model component is simulated through MATLAB's Simulink program. The intensiv model development life cycle is a.s follows: Identify source documents; identify model scope; update schedule; preliminary design review; develop model requirements; update model.. scope; update schedule; detailed design review; create/modify library component; implement library components reference; implement subsystem components; develop a test script; run the test script; develop users guide; send model out for peer review; the model is sent out for verifictionlvalidation; if there is empirical data, a validation data package is generated; if there is not empirical data, a verification package is generated; the test results are then reviewed; and finally, the user. requests accreditation, and a statement of accreditation is prepared. Once each component model is reviewed and approved, they are intertwined together into one integrated model. This integrated model is then tested itself, through a test script and autotest, so that it can be concluded that all models work conjointly, for a single purpose. The component I was assigned, specifically, was a

  16. Modelling cointegration in the vector autoregressive model

    DEFF Research Database (Denmark)

    Johansen, Søren

    2000-01-01

    A survey is given of some results obtained for the cointegrated VAR. The Granger representation theorem is discussed and the notions of cointegration and common trends are defined. The statistical model for cointegrated I(1) variables is defined, and it is shown how hypotheses on the cointegrating...... relations can be estimated under suitable identification conditions. The asymptotic theory is briefly mentioned and a few economic applications of the cointegration model are indicated....

  17. World Magnetic Model 2015

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The World Magnetic Model is the standard model used by the U.S. Department of Defense, the U.K. Ministry of Defence, the North Atlantic Treaty Organization (NATO)...

  18. Emissions Modeling Clearinghouse

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Emissions Modeling Clearinghouse (EMCH) supports and promotes emissions modeling activities both internal and external to the EPA. Through this site, the EPA...

  19. Chip Multithreaded Consistency Model

    Institute of Scientific and Technical Information of China (English)

    Zu-Song Li; Dan-Dan Huan; Wei-Wu Hu; Zhi-Min Tang

    2008-01-01

    Multithreaded technique is the developing trend of high performance processor. Memory consistency model is essential to the correctness, performance and complexity of multithreaded processor. The chip multithreaded consistency model adapting to multithreaded processor is proposed in this paper. The restriction imposed on memory event ordering by chip multithreaded consistency is presented and formalized. With the idea of critical cycle built by Wei-Wu Hu, we prove that the proposed chip multithreaded consistency model satisfies the criterion of correct execution of sequential consistency model. Chip multithreaded consistency model provides a way of achieving high performance compared with sequential consistency model and ensures the compatibility of software that the execution result in multithreaded processor is the same as the execution result in uniprocessor. The implementation strategy of chip multithreaded consistency model in Godson-2 SMT processor is also proposed. Godson-2 SMT processor supports chip multithreaded consistency model correctly by exception scheme based on the sequential memory access queue of each thread.

  20. Models (Part 1).

    Science.gov (United States)

    Callison, Daniel

    2002-01-01

    Defines models and describes information search models that can be helpful to instructional media specialists in meeting users' abilities and information needs. Explains pathfinders and Kuhlthau's information search process, including the pre-writing information search process. (LRW)

  1. Modeling EERE deployment programs

    Energy Technology Data Exchange (ETDEWEB)

    Cort, K. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hostick, D. J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Belzer, D. B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Livingston, O. V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2007-11-01

    The purpose of the project was to identify and characterize the modeling of deployment programs within the EERE Technology Development (TD) programs, address possible improvements to the modeling process, and note gaps in knowledge for future research.

  2. Modeling Complex Time Limits

    Directory of Open Access Journals (Sweden)

    Oleg Svatos

    2013-01-01

    Full Text Available In this paper we analyze complexity of time limits we can find especially in regulated processes of public administration. First we review the most popular process modeling languages. There is defined an example scenario based on the current Czech legislature which is then captured in discussed process modeling languages. Analysis shows that the contemporary process modeling languages support capturing of the time limit only partially. This causes troubles to analysts and unnecessary complexity of the models. Upon unsatisfying results of the contemporary process modeling languages we analyze the complexity of the time limits in greater detail and outline lifecycles of a time limit using the multiple dynamic generalizations pattern. As an alternative to the popular process modeling languages there is presented PSD process modeling language, which supports the defined lifecycles of a time limit natively and therefore allows keeping the models simple and easy to understand.

  3. Laboratory of Biological Modeling

    Data.gov (United States)

    Federal Laboratory Consortium — The Laboratory of Biological Modeling is defined by both its methodologies and its areas of application. We use mathematical modeling in many forms and apply it to...

  4. Laboratory of Biological Modeling

    Data.gov (United States)

    Federal Laboratory Consortium — The Laboratory of Biological Modeling is defined by both its methodologies and its areas of application. We use mathematical modeling in many forms and apply it to a...

  5. Modeling DNA Replication.

    Science.gov (United States)

    Bennett, Joan

    1998-01-01

    Recommends the use of a model of DNA made out of Velcro to help students visualize the steps of DNA replication. Includes a materials list, construction directions, and details of the demonstration using the model parts. (DDR)

  6. LAT Background Models

    Data.gov (United States)

    National Aeronautics and Space Administration — The Galactic model is a spatial and spectral template. The model for the Galactic diffuse emission was developed using spectral line surveys of HI and CO (as a...

  7. Graphical Models with R

    DEFF Research Database (Denmark)

    Højsgaard, Søren; Edwards, David; Lauritzen, Steffen

    Graphical models in their modern form have been around since the late 1970s and appear today in many areas of the sciences. Along with the ongoing developments of graphical models, a number of different graphical modeling software programs have been written over the years. In recent years many...... of these software developments have taken place within the R community, either in the form of new packages or by providing an R ingerface to existing software. This book attempts to give the reader a gentle introduction to graphical modeling using R and the main features of some of these packages. In addition......, the book provides examples of how more advanced aspects of graphical modeling can be represented and handled within R. Topics covered in the seven chapters include graphical models for contingency tables, Gaussian and mixed graphical models, Bayesian networks and modeling high dimensional data...

  8. Model comparison in ANOVA.

    Science.gov (United States)

    Rouder, Jeffrey N; Engelhardt, Christopher R; McCabe, Simon; Morey, Richard D

    2016-12-01

    Analysis of variance (ANOVA), the workhorse analysis of experimental designs, consists of F-tests of main effects and interactions. Yet, testing, including traditional ANOVA, has been recently critiqued on a number of theoretical and practical grounds. In light of these critiques, model comparison and model selection serve as an attractive alternative. Model comparison differs from testing in that one can support a null or nested model vis-a-vis a more general alternative by penalizing more flexible models. We argue this ability to support more simple models allows for more nuanced theoretical conclusions than provided by traditional ANOVA F-tests. We provide a model comparison strategy and show how ANOVA models may be reparameterized to better address substantive questions in data analysis.

  9. Controlling Modelling Artifacts

    DEFF Research Database (Denmark)

    Smith, Michael James Andrew; Nielson, Flemming; Nielson, Hanne Riis

    2011-01-01

    the possible configurations of the system (for example, by counting the number of components in a certain state). We motivate our methodology with a case study of the LMAC protocol for wireless sensor networks. In particular, we investigate the accuracy of a recently proposed high-level model of LMAC......When analysing the performance of a complex system, we typically build abstract models that are small enough to analyse, but still capture the relevant details of the system. But it is difficult to know whether the model accurately describes the real system, or if its behaviour is due to modelling...... artifacts that were inadvertently introduced. In this paper, we propose a novel methodology to reason about modelling artifacts, given a detailed model and a highlevel (more abstract) model of the same system. By a series of automated abstraction steps, we lift the detailed model to the same state space...

  10. World Magnetic Model 2010

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The World Magnetic Model is the standard model used by the U.S. Department of Defense, the U.K. Ministry of Defence, the North Atlantic Treaty Organization (NATO)...

  11. Consistent model driven architecture

    Science.gov (United States)

    Niepostyn, Stanisław J.

    2015-09-01

    The goal of the MDA is to produce software systems from abstract models in a way where human interaction is restricted to a minimum. These abstract models are based on the UML language. However, the semantics of UML models is defined in a natural language. Subsequently the verification of consistency of these diagrams is needed in order to identify errors in requirements at the early stage of the development process. The verification of consistency is difficult due to a semi-formal nature of UML diagrams. We propose automatic verification of consistency of the series of UML diagrams originating from abstract models implemented with our consistency rules. This Consistent Model Driven Architecture approach enables us to generate automatically complete workflow applications from consistent and complete models developed from abstract models (e.g. Business Context Diagram). Therefore, our method can be used to check practicability (feasibility) of software architecture models.

  12. Bounding species distribution models

    Directory of Open Access Journals (Sweden)

    Thomas J. STOHLGREN, Catherine S. JARNEVICH, Wayne E. ESAIAS,Jeffrey T. MORISETTE

    2011-10-01

    Full Text Available Species distribution models are increasing in popularity for mapping suitable habitat for species of management concern. Many investigators now recognize that extrapolations of these models with geographic information systems (GIS might be sensitive to the environmental bounds of the data used in their development, yet there is no recommended best practice for “clamping” model extrapolations. We relied on two commonly used modeling approaches: classification and regression tree (CART and maximum entropy (Maxent models, and we tested a simple alteration of the model extrapolations, bounding extrapolations to the maximum and minimum values of primary environmental predictors, to provide a more realistic map of suitable habitat of hybridized Africanized honey bees in the southwestern United States. Findings suggest that multiple models of bounding, and the most conservative bounding of species distribution models, like those presented here, should probably replace the unbounded or loosely bounded techniques currently used [Current Zoology 57 (5: 642–647, 2011].

  13. ASC Champ Orbit Model

    DEFF Research Database (Denmark)

    Riis, Troels; Jørgensen, John Leif

    1999-01-01

    This documents describes a test of the implementation of the ASC orbit model for the Champ satellite.......This documents describes a test of the implementation of the ASC orbit model for the Champ satellite....

  14. CCF model comparison

    Energy Technology Data Exchange (ETDEWEB)

    Pulkkinen, U. [VTT Industrial Systems (Finland)

    2004-04-01

    The report describes a simple comparison of two CCF-models, the ECLM, and the Beta-model. The objective of the comparison is to identify differences in the results of the models by applying the models in some simple test data cases. The comparison focuses mainly on theoretical aspects of the above mentioned CCF-models. The properties of the model parameter estimates in the data cases is also discussed. The practical aspects in using and estimating CCFmodels in real PSA context (e.g. the data interpretation, properties of computer tools, the model documentation) are not discussed in the report. Similarly, the qualitative CCF-analyses needed in using the models are not discussed in the report. (au)

  15. The ATLAS Analysis Model

    CERN Multimedia

    Amir Farbin

    The ATLAS Analysis Model is a continually developing vision of how to reconcile physics analysis requirements with the ATLAS offline software and computing model constraints. In the past year this vision has influenced the evolution of the ATLAS Event Data Model, the Athena software framework, and physics analysis tools. These developments, along with the October Analysis Model Workshop and the planning for CSC analyses have led to a rapid refinement of the ATLAS Analysis Model in the past few months. This article introduces some of the relevant issues and presents the current vision of the future ATLAS Analysis Model. Event Data Model The ATLAS Event Data Model (EDM) consists of several levels of details, each targeted for a specific set of tasks. For example the Event Summary Data (ESD) stores calorimeter cells and tracking system hits thereby permitting many calibration and alignment tasks, but will be only accessible at particular computing sites with potentially large latency. In contrast, the Analysis...

  16. Modeling Digital Video Database

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The main purpose of the model is to present how the UnifiedModeling L anguage (UML) can be used for modeling digital video database system (VDBS). It demonstrates the modeling process that can be followed during the analysis phase of complex applications. In order to guarantee the continuity mapping of the mo dels, the authors propose some suggestions to transform the use case diagrams in to an object diagram, which is one of the main diagrams for the next development phases.

  17. Making business models

    DEFF Research Database (Denmark)

    Gudiksen, Sune Klok; Poulsen, Søren Bolvig; Buur, Jacob

    2014-01-01

    Well-established companies are currently struggling to secure profits due to the pressure from new players' business models as they take advantage of communication technology and new business-model configurations. Because of this, the business model research field flourishes currently; however, t...... illustrates how the application of participatory business model design toolsets can open up discussions on alternative scenarios through improvisation, mock-up making and design game playing, before qualitative judgment on the most promising scenario is carried out....

  18. Artificial neural network modelling

    CERN Document Server

    Samarasinghe, Sandhya

    2016-01-01

    This book covers theoretical aspects as well as recent innovative applications of Artificial Neural networks (ANNs) in natural, environmental, biological, social, industrial and automated systems. It presents recent results of ANNs in modelling small, large and complex systems under three categories, namely, 1) Networks, Structure Optimisation, Robustness and Stochasticity 2) Advances in Modelling Biological and Environmental Systems and 3) Advances in Modelling Social and Economic Systems. The book aims at serving undergraduates, postgraduates and researchers in ANN computational modelling. .

  19. Hierarchical Bass model

    CERN Document Server

    Tashiro, Tohru

    2013-01-01

    We propose a new model about diffusion of a product which includes a memory of how many adopters or advertisements a non-adopter met, where (non-)adopters mean people (not) possessing the product. This effect is lacking in the Bass model. As an application, we utilize the model to fit the iPod sales data, and so the better agreement is obtained than the Bass model.

  20. Optimization modeling with spreadsheets

    CERN Document Server

    Baker, Kenneth R

    2015-01-01

    An accessible introduction to optimization analysis using spreadsheets Updated and revised, Optimization Modeling with Spreadsheets, Third Edition emphasizes model building skills in optimization analysis. By emphasizing both spreadsheet modeling and optimization tools in the freely available Microsoft® Office Excel® Solver, the book illustrates how to find solutions to real-world optimization problems without needing additional specialized software. The Third Edition includes many practical applications of optimization models as well as a systematic framework that il

  1. Model of magnetostrictive actuator

    Institute of Scientific and Technical Information of China (English)

    LI Lin; ZHANG Yuan-yuan

    2005-01-01

    The hysteresis of the magnetostrictive actuator was studied. A mathematical model of the hysteresis loop was obtained on the basis of experiment. This model depends on the frequency and the amplitude of the alternating current inputted to the magnetostrictive actuator. Based on the model, the effect of hysteresis on dynamic output of the magnetostrictive actuator was investigated. Then how to consider hysteresis and establish a dynamic model of a magnetostrictive actuator system is discussed when a practical system was designed and applied.

  2. Toric models of graphs

    CERN Document Server

    Buczyńska, Weronika

    2010-01-01

    We define toric projective model of a trivalent graph as a generalization of a binary symmetric model of a trivalent phylogenetic tree. Generators of the projective coordinate ring of the models of graphs with one cycle are explicitly described. The models of graphs with the same topological invariants are deformation equivalent and share the same Hilbert function. We also provide an algorithm to compute the Hilbert function.

  3. Crowdsourcing Business Model Innovation

    DEFF Research Database (Denmark)

    Waldner, Florian; Poetz, Marion

    Successfully adapting existing business models or developing new ones significantly influences a firm?s ability to generate profits and develop competitive advantages. However, business model innovation is perceived as a complex, risky and uncertain process and its success strongly depends on whe...... models in the podcast industry, we provide first exploratory insights into the value of crowdsourcing for innovating a firm?s business model, and discuss which characteristics of crowd-contributors increase the quantity and quality of the outcome....

  4. Avionics Architecture Modelling Language

    Science.gov (United States)

    Alana, Elena; Naranjo, Hector; Valencia, Raul; Medina, Alberto; Honvault, Christophe; Rugina, Ana; Panunzia, Marco; Dellandrea, Brice; Garcia, Gerald

    2014-08-01

    This paper presents the ESA AAML (Avionics Architecture Modelling Language) study, which aimed at advancing the avionics engineering practices towards a model-based approach by (i) identifying and prioritising the avionics-relevant analyses, (ii) specifying the modelling language features necessary to support the identified analyses, and (iii) recommending/prototyping software tooling to demonstrate the automation of the selected analyses based on a modelling language and compliant with the defined specification.

  5. GIS Conceptual Data Model

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    In order to set up a conceptual data model that reflects the real world as accurately as possible,this paper firstly reviews and analyzes the disadvantages of previous conceptual data models used by traditional GIS in simulating geographic space,gives a new explanation to geographic space and analyzes its various essential characteristics.Finally,this paper proposes several detailed key points for designing a new type of GIS data model and gives a simple holistic GIS data model.

  6. Hierarchical Bass model

    Science.gov (United States)

    Tashiro, Tohru

    2014-03-01

    We propose a new model about diffusion of a product which includes a memory of how many adopters or advertisements a non-adopter met, where (non-)adopters mean people (not) possessing the product. This effect is lacking in the Bass model. As an application, we utilize the model to fit the iPod sales data, and so the better agreement is obtained than the Bass model.

  7. Modelling of Corrosion Cracks

    DEFF Research Database (Denmark)

    Thoft-Christensen, Palle

    Modelling of corrosion cracking of reinforced concrete structures is complicated as a great number of uncertain factors are involved. To get a reliable modelling a physical and mechanical understanding of the process behind corrosion in needed.......Modelling of corrosion cracking of reinforced concrete structures is complicated as a great number of uncertain factors are involved. To get a reliable modelling a physical and mechanical understanding of the process behind corrosion in needed....

  8. Model Checking Feature Interactions

    DEFF Research Database (Denmark)

    Le Guilly, Thibaut; Olsen, Petur; Pedersen, Thomas;

    2015-01-01

    This paper presents an offline approach to analyzing feature interactions in embedded systems. The approach consists of a systematic process to gather the necessary information about system components and their models. The model is first specified in terms of predicates, before being refined to t...... to timed automata. The consistency of the model is verified at different development stages, and the correct linkage between the predicates and their semantic model is checked. The approach is illustrated on a use case from home automation....

  9. Photovoltaic sources modeling

    CERN Document Server

    Petrone, Giovanni; Spagnuolo, Giovanni

    2016-01-01

    This comprehensive guide surveys all available models for simulating a photovoltaic (PV) generator at different levels of granularity, from cell to system level, in uniform as well as in mismatched conditions. Providing a thorough comparison among the models, engineers have all the elements needed to choose the right PV array model for specific applications or environmental conditions matched with the model of the electronic circuit used to maximize the PV power production.

  10. Climate models and scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Fortelius, C.; Holopainen, E.; Kaurola, J.; Ruosteenoja, K.; Raeisaenen, J. [Helsinki Univ. (Finland). Dept. of Meteorology

    1996-12-31

    In recent years the modelling of interannual climate variability has been studied, the atmospheric energy and water cycles, and climate simulations with the ECHAM3 model. In addition, the climate simulations of several models have been compared with special emphasis in the area of northern Europe

  11. Modeling EERE Deployment Programs

    Energy Technology Data Exchange (ETDEWEB)

    Cort, K. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hostick, D. J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Belzer, D. B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Livingston, O. V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2007-11-01

    This report compiles information and conclusions gathered as part of the “Modeling EERE Deployment Programs” project. The purpose of the project was to identify and characterize the modeling of deployment programs within the EERE Technology Development (TD) programs, address possible improvements to the modeling process, and note gaps in knowledge in which future research is needed.

  12. Zephyr - the prediction models

    DEFF Research Database (Denmark)

    Nielsen, Torben Skov; Madsen, Henrik; Nielsen, Henrik Aalborg

    2001-01-01

    This paper briefly describes new models and methods for predicationg the wind power output from wind farms. The system is being developed in a project which has the research organization Risø and the department of Informatics and Mathematical Modelling (IMM) as the modelling team and all the Dani...

  13. Generalized Poisson sigma models

    CERN Document Server

    Batalin, I; Batalin, Igor; Marnelius, Robert

    2001-01-01

    A general master action in terms of superfields is given which generates generalized Poisson sigma models by means of a natural ghost number prescription. The simplest representation is the sigma model considered by Cattaneo and Felder. For Dirac brackets considerably more general models are generated.

  14. Dynamic term structure models

    DEFF Research Database (Denmark)

    Andreasen, Martin Møller; Meldrum, Andrew

    This paper studies whether dynamic term structure models for US nominal bond yields should enforce the zero lower bound by a quadratic policy rate or a shadow rate specification. We address the question by estimating quadratic term structure models (QTSMs) and shadow rate models with at most four...

  15. Model Breaking Points Conceptualized

    Science.gov (United States)

    Vig, Rozy; Murray, Eileen; Star, Jon R.

    2014-01-01

    Current curriculum initiatives (e.g., National Governors Association Center for Best Practices and Council of Chief State School Officers 2010) advocate that models be used in the mathematics classroom. However, despite their apparent promise, there comes a point when models break, a point in the mathematical problem space where the model cannot,…

  16. Model-based geostatistics

    CERN Document Server

    Diggle, Peter J

    2007-01-01

    Model-based geostatistics refers to the application of general statistical principles of modeling and inference to geostatistical problems. This volume provides a treatment of model-based geostatistics and emphasizes on statistical methods and applications. It also features analyses of datasets from a range of scientific contexts.

  17. Modelling Vocabulary Loss

    Science.gov (United States)

    Meara, Paul

    2004-01-01

    This paper describes some simple simulation models of vocabulary attrition. The attrition process is modelled using a random autonomous Boolean network model, and some parallels with real attrition data are drawn. The paper argues that applying a complex systems approach to attrition can provide some important insights, which suggest that real…

  18. Modeling of ultrasound transducers

    DEFF Research Database (Denmark)

    Bæk, David

    This Ph.D. dissertation addresses ultrasound transducer modeling for medical ultrasound imaging and combines the modeling with the ultrasound simulation program Field II. The project firstly presents two new models for spatial impulse responses (SIR)s to a rectangular elevation focused transducer...

  19. Model Rockets and Microchips.

    Science.gov (United States)

    Fitzsimmons, Charles P.

    1986-01-01

    Points out the instructional applications and program possibilities of a unit on model rocketry. Describes the ways that microcomputers can assist in model rocket design and in problem calculations. Provides a descriptive listing of model rocket software for the Apple II microcomputer. (ML)

  20. A Model Performance

    Science.gov (United States)

    Thornton, Bradley D.; Smalley, Robert A.

    2008-01-01

    Building information modeling (BIM) uses three-dimensional modeling concepts, information technology and interoperable software to design, construct and operate a facility. However, BIM can be more than a tool for virtual modeling--it can provide schools with a 3-D walkthrough of a project while it still is on the electronic drawing board. BIM can…

  1. Rock Properties Model

    Energy Technology Data Exchange (ETDEWEB)

    C. Lum

    2004-09-16

    The purpose of this model report is to document the Rock Properties Model version 3.1 with regard to input data, model methods, assumptions, uncertainties and limitations of model results, and qualification status of the model. The report also documents the differences between the current and previous versions and validation of the model. The rock properties model provides mean matrix and lithophysae porosity, and the cross-correlated mean bulk density as direct input to the ''Saturated Zone Flow and Transport Model Abstraction'', MDL-NBS-HS-000021, REV 02 (BSC 2004 [DIRS 170042]). The constraints, caveats, and limitations associated with this model are discussed in Section 6.6 and 8.2. Model validation accomplished by corroboration with data not cited as direct input is discussed in Section 7. The revision of this model report was performed as part of activities being conducted under the ''Technical Work Plan for: The Integrated Site Model, Revision 05'' (BSC 2004 [DIRS 169635]). The purpose of this revision is to bring the report up to current procedural requirements and address the Regulatory Integration Team evaluation comments. The work plan describes the scope, objectives, tasks, methodology, and procedures for this process.

  2. Modeling typical performance measures

    NARCIS (Netherlands)

    Weekers, Anke Martine

    2009-01-01

    In the educational, employment, and clinical context, attitude and personality inventories are used to measure typical performance traits. Statistical models are applied to obtain latent trait estimates. Often the same statistical models as the models used in maximum performance measurement are appl

  3. Modern Media Education Models

    Science.gov (United States)

    Fedorov, Alexander

    2011-01-01

    The author supposed that media education models can be divided into the following groups: (1) educational-information models (the study of the theory, history, language of media culture, etc.), based on the cultural, aesthetic, semiotic, socio-cultural theories of media education; (2) educational-ethical models (the study of moral, religions,…

  4. Modelling: Nature and Use

    DEFF Research Database (Denmark)

    2011-01-01

    Engineering of products and processes is increasingly “model-centric”. Models in their multitudinous forms are ubiquitous, being heavily used for a range of decision making activities across all life cycle phases. This chapter gives an overview of what is a model, the principal activities in the ...

  5. Modeling and Remodeling Writing

    Science.gov (United States)

    Hayes, John R.

    2012-01-01

    In Section 1 of this article, the author discusses the succession of models of adult writing that he and his colleagues have proposed from 1980 to the present. He notes the most important changes that differentiate earlier and later models and discusses reasons for the changes. In Section 2, he describes his recent efforts to model young…

  6. Crushed Salt Constitutive Model

    Energy Technology Data Exchange (ETDEWEB)

    Callahan, G.D.

    1999-02-01

    The constitutive model used to describe the deformation of crushed salt is presented in this report. Two mechanisms -- dislocation creep and grain boundary diffusional pressure solution -- are combined to form the basis for the constitutive model governing the deformation of crushed salt. The constitutive model is generalized to represent three-dimensional states of stress. Upon complete consolidation, the crushed-salt model reproduces the Multimechanism Deformation (M-D) model typically used for the Waste Isolation Pilot Plant (WIPP) host geological formation salt. New shear consolidation tests are combined with an existing database that includes hydrostatic consolidation and shear consolidation tests conducted on WIPP and southeastern New Mexico salt. Nonlinear least-squares model fitting to the database produced two sets of material parameter values for the model -- one for the shear consolidation tests and one for a combination of the shear and hydrostatic consolidation tests. Using the parameter values determined from the fitted database, the constitutive model is validated against constant strain-rate tests. Shaft seal problems are analyzed to demonstrate model-predicted consolidation of the shaft seal crushed-salt component. Based on the fitting statistics, the ability of the model to predict the test data, and the ability of the model to predict load paths and test data outside of the fitted database, the model appears to capture the creep consolidation behavior of crushed salt reasonably well.

  7. Simplicial chiral models

    CERN Document Server

    Rossi, P; Rossi, Paolo; Tan, Chung I

    1995-01-01

    Principal chiral models on a d-1 dimensional simplex are introduced and studied analytically in the large N limit. The d = 0 , 2, 4 and \\infty models are explicitly solved. Relationship with standard lattice models and with few-matrix systems in the double scaling limit are discussed.

  8. Modeling agriculture in the Community Land Model

    Directory of Open Access Journals (Sweden)

    B. Drewniak

    2013-04-01

    Full Text Available The potential impact of climate change on agriculture is uncertain. In addition, agriculture could influence above- and below-ground carbon storage. Development of models that represent agriculture is necessary to address these impacts. We have developed an approach to integrate agriculture representations for three crop types – maize, soybean, and spring wheat – into the coupled carbon–nitrogen version of the Community Land Model (CLM, to help address these questions. Here we present the new model, CLM-Crop, validated against observations from two AmeriFlux sites in the United States, planted with maize and soybean. Seasonal carbon fluxes compared well with field measurements for soybean, but not as well for maize. CLM-Crop yields were comparable with observations in countries such as the United States, Argentina, and China, although the generality of the crop model and its lack of technology and irrigation made direct comparison difficult. CLM-Crop was compared against the standard CLM3.5, which simulates crops as grass. The comparison showed improvement in gross primary productivity in regions where crops are the dominant vegetation cover. Crop yields and productivity were negatively correlated with temperature and positively correlated with precipitation, in agreement with other modeling studies. In case studies with the new crop model looking at impacts of residue management and planting date on crop yield, we found that increased residue returned to the litter pool increased crop yield, while reduced residue returns resulted in yield decreases. Using climate controls to signal planting date caused different responses in different crops. Maize and soybean had opposite reactions: when low temperature threshold resulted in early planting, maize responded with a loss of yield, but soybean yields increased. Our improvements in CLM demonstrate a new capability in the model – simulating agriculture in a realistic way, complete with

  9. Process modeling style

    CERN Document Server

    Long, John

    2014-01-01

    Process Modeling Style focuses on other aspects of process modeling beyond notation that are very important to practitioners. Many people who model processes focus on the specific notation used to create their drawings. While that is important, there are many other aspects to modeling, such as naming, creating identifiers, descriptions, interfaces, patterns, and creating useful process documentation. Experience author John Long focuses on those non-notational aspects of modeling, which practitioners will find invaluable. Gives solid advice for creating roles, work produ

  10. Reconstruction of inflation models

    Energy Technology Data Exchange (ETDEWEB)

    Myrzakulov, Ratbay; Sebastiani, Lorenzo [Eurasian National University, Department of General and Theoretical Physics and Eurasian Center for Theoretical Physics, Astana (Kazakhstan); Zerbini, Sergio [Universita di Trento, Dipartimento di Fisica, Trento (Italy); TIFPA, Istituto Nazionale di Fisica Nucleare, Trento (Italy)

    2015-05-15

    In this paper, we reconstruct viable inflationary models by starting from spectral index and tensor-to-scalar ratio from Planck observations. We analyze three different kinds of models: scalar field theories, fluid cosmology, and f(R)-modified gravity. We recover the well-known R{sup 2} inflation in Jordan-frame and Einstein-frame representation, the massive scalar inflaton models and two models of inhomogeneous fluid. A model of R{sup 2} correction to Einstein's gravity plus a ''cosmological constant'' with an exact solution for early-time acceleration is reconstructed. (orig.)

  11. Models of Goldstone gauginos

    Science.gov (United States)

    Alves, Daniele S. M.; Galloway, Jamison; McCullough, Matthew; Weiner, Neal

    2016-04-01

    Models with Dirac gauginos are appealing scenarios for physics beyond the Standard Model. They have smaller radiative corrections to scalar soft masses, a suppression of certain supersymmetry (SUSY) production processes at the LHC, and ameliorated flavor constraints. Unfortunately, they are generically plagued by tachyons charged under the Standard Model, and attempts to eliminate such states typically spoil the positive features. The recently proposed "Goldstone gaugino" mechanism provides a simple realization of Dirac gauginos that is automatically free of dangerous tachyonic states. We provide details on this mechanism and explore models for its origin. In particular, we find SUSY QCD models that realize this idea simply and discuss scenarios for unification.

  12. Modeling Epidemic Network Failures

    DEFF Research Database (Denmark)

    Ruepp, Sarah Renée; Fagertun, Anna Manolova

    2013-01-01

    This paper presents the implementation of a failure propagation model for transport networks when multiple failures occur resulting in an epidemic. We model the Susceptible Infected Disabled (SID) epidemic model and validate it by comparing it to analytical solutions. Furthermore, we evaluate...... the SID model’s behavior and impact on the network performance, as well as the severity of the infection spreading. The simulations are carried out in OPNET Modeler. The model provides an important input to epidemic connection recovery mechanisms, and can due to its flexibility and versatility be used...... to evaluate multiple epidemic scenarios in various network types....

  13. Auxiliary Deep Generative Models

    DEFF Research Database (Denmark)

    Maaløe, Lars; Sønderby, Casper Kaae; Sønderby, Søren Kaae;

    2016-01-01

    Deep generative models parameterized by neural networks have recently achieved state-of-the-art performance in unsupervised and semi-supervised learning. We extend deep generative models with auxiliary variables which improves the variational approximation. The auxiliary variables leave...... the generative model unchanged but make the variational distribution more expressive. Inspired by the structure of the auxiliary variable we also propose a model with two stochastic layers and skip connections. Our findings suggest that more expressive and properly specified deep generative models converge...

  14. UZ Colloid Transport Model

    Energy Technology Data Exchange (ETDEWEB)

    M. McGraw

    2000-04-13

    The UZ Colloid Transport model development plan states that the objective of this Analysis/Model Report (AMR) is to document the development of a model for simulating unsaturated colloid transport. This objective includes the following: (1) use of a process level model to evaluate the potential mechanisms for colloid transport at Yucca Mountain; (2) Provide ranges of parameters for significant colloid transport processes to Performance Assessment (PA) for the unsaturated zone (UZ); (3) Provide a basis for development of an abstracted model for use in PA calculations.

  15. Transgenesis for pig models

    Science.gov (United States)

    Yum, Soo-Young; Yoon, Ki-Young; Lee, Choong-Il; Lee, Byeong-Chun

    2016-01-01

    Animal models, particularly pigs, have come to play an important role in translational biomedical research. There have been many pig models with genetically modifications via somatic cell nuclear transfer (SCNT). However, because most transgenic pigs have been produced by random integration to date, the necessity for more exact gene-mutated models using recombinase based conditional gene expression like mice has been raised. Currently, advanced genome-editing technologies enable us to generate specific gene-deleted and -inserted pig models. In the future, the development of pig models with gene editing technologies could be a valuable resource for biomedical research. PMID:27030199

  16. CRAC2 model description

    Energy Technology Data Exchange (ETDEWEB)

    Ritchie, L.T.; Alpert, D.J.; Burke, R.P.; Johnson, J.D.; Ostmeyer, R.M.; Aldrich, D.C.; Blond, R.M.

    1984-03-01

    The CRAC2 computer code is a revised version of CRAC (Calculation of Reactor Accident Consequences) which was developed for the Reactor Safety Study. This document provides an overview of the CRAC2 code and a description of each of the models used. Significant improvements incorporated into CRAC2 include an improved weather sequence sampling technique, a new evacuation model, and new output capabilities. In addition, refinements have been made to the atmospheric transport and deposition model. Details of the modeling differences between CRAC2 and CRAC are emphasized in the model descriptions.

  17. Mechanics of materials model

    Science.gov (United States)

    Meister, Jeffrey P.

    1987-01-01

    The Mechanics of Materials Model (MOMM) is a three-dimensional inelastic structural analysis code for use as an early design stage tool for hot section components. MOMM is a stiffness method finite element code that uses a network of beams to characterize component behavior. The MOMM contains three material models to account for inelastic material behavior. These include the simplified material model, which assumes a bilinear stress-strain response; the state-of-the-art model, which utilizes the classical elastic-plastic-creep strain decomposition; and Walker's viscoplastic model, which accounts for the interaction between creep and plasticity that occurs under cyclic loading conditions.

  18. Models as Mediators

    DEFF Research Database (Denmark)

    Sommerlund, Julie

    from laboratory studies, (Latour 1979; Lynch 1985; Sommerlund 2004 (2007); Sommerlund 2006) and is complemented by the attention paid to the "mediator" by Hennion (1989; 1997; 2005). The empirical focus will be on a central - but overlooked - actor of branding and advertising; the model. The model has...... solely been theorized within cultural studies (Craik 1994) as feminine spectacle, but has been neglected as mediator and actor. This paper will argue that models are co-producers of brands, and vice versa. Empirically, the paper will present interviews with models, model-scouts, agents, and advertisers...

  19. Mathematical modelling techniques

    CERN Document Server

    Aris, Rutherford

    1995-01-01

    ""Engaging, elegantly written."" - Applied Mathematical ModellingMathematical modelling is a highly useful methodology designed to enable mathematicians, physicists and other scientists to formulate equations from a given nonmathematical situation. In this elegantly written volume, a distinguished theoretical chemist and engineer sets down helpful rules not only for setting up models but also for solving the mathematical problems they pose and for evaluating models.The author begins with a discussion of the term ""model,"" followed by clearly presented examples of the different types of mode

  20. Validated dynamic flow model

    DEFF Research Database (Denmark)

    Knudsen, Torben

    2011-01-01

    The purpose with this deliverable 2.5 is to use fresh experimental data for validation and selection of a flow model to be used for control design in WP3-4. Initially the idea was to investigate the models developed in WP2. However, in the project it was agreed to include and focus on a additive...... model turns out not to be useful for prediction of the flow. Moreover, standard Box Jenkins model structures and multiple output auto regressive models proves to be superior as they can give useful predictions of the flow....

  1. Models of the universe

    Science.gov (United States)

    Fischer, Arthur E.

    1996-01-01

    In this paper a theory of models of the universe is proposed. We refer to such models ascosmological models, where a cosmological model is defined as an Einstein-inextendible Einstein spacetime. A cosmological model isabsolute if it is a Lorentz-inextendible Einstein spacetime,predictive if it is globally hyperbolic, andnon-predictive if it is nonglobally-hyperbolic. We discuss several features of these models in the study of cosmology. As an example, any compact Einstein spacetime is always a non-predictive absolute cosmological model, whereas a noncompact complete Einstein spacetime is an absolute cosmological model which may be either predictive or non-predictive. We discuss the important role played by maximal Einstein spacetimes. In particular, we examine the possible proper Lorentz-extensions of such spacetimes, and show that a spatially compact maximal Einstein spacetime is exclusively either a predictive cosmological model or a proper sub-spacetime of a non-predictive cosmological model. Provided that the Strong Cosmic Censorship conjecture is true, a generic spatially compact maximal Einstein spacetime must be a predictive cosmological model. It isconjectured that the Strong Cosmic Censorship conjecture isnot true, and converting a vice to a virtue it is argued that the failure of the Strong Cosmic Censorship conjecture would point to what may be general relativity's greatest prediction of all, namely,that general relativity predicts that general relativity cannot predict the entire history of the universe.

  2. TEAMS Model Analyzer

    Science.gov (United States)

    Tijidjian, Raffi P.

    2010-01-01

    The TEAMS model analyzer is a supporting tool developed to work with models created with TEAMS (Testability, Engineering, and Maintenance System), which was developed by QSI. In an effort to reduce the time spent in the manual process that each TEAMS modeler must perform in the preparation of reporting for model reviews, a new tool has been developed as an aid to models developed in TEAMS. The software allows for the viewing, reporting, and checking of TEAMS models that are checked into the TEAMS model database. The software allows the user to selectively model in a hierarchical tree outline view that displays the components, failure modes, and ports. The reporting features allow the user to quickly gather statistics about the model, and generate an input/output report pertaining to all of the components. Rules can be automatically validated against the model, with a report generated containing resulting inconsistencies. In addition to reducing manual effort, this software also provides an automated process framework for the Verification and Validation (V&V) effort that will follow development of these models. The aid of such an automated tool would have a significant impact on the V&V process.

  3. Aware design models

    DEFF Research Database (Denmark)

    Tamke, Martin

    2015-01-01

    Appearing almost alive, a novel set of computational design models can become an active counterpart for architects in the design process. The ability to loop, sense and query and the integration of near real-time simulation provide these models with a depth and agility that allows for instant...... and informed feedback. Introducing the term "Aware models", the paper investigates how computational models become an enabler for a better informed architectural design practice, through the embedding of knowledge about constraints, behaviour and processes of formation and making into generative design models....... The inspection of several computational design projects in architectural research highlights three different types of awareness a model can possess and devises strategies to establish and finally design with aware models. This design practice is collaborative in nature and characterized by a bidirectional flow...

  4. CREDIT RISK. DETERMINATION MODELS

    Directory of Open Access Journals (Sweden)

    MIHAELA GRUIESCU

    2012-01-01

    Full Text Available The internationalization of financial flows and banking and the rapid development of markets have changed the financial sector, causing him to respond with force and imagination. Under these conditions, the concerns of financial and banking institutions, rating institutions are increasingly turning to find the best solutions to hedge risks and maximize profits. This paper aims to present a number of advantages, but also limits the Merton model, the first structural model for modeling credit risk. Also, some are extensions of the model, some empirical research and performance known, others such as state-dependent models (SDM, which together with the liquidation process models (LPM, are two recent efforts in the structural models, show different phenomena in real life.

  5. Multiscale Modeling of Recrystallization

    Energy Technology Data Exchange (ETDEWEB)

    Godfrey, A.W.; Holm, E.A.; Hughes, D.A.; Lesar, R.; Miodownik, M.A.

    1998-12-07

    We propose a multi length scale approach to modeling recrystallization which links a dislocation model, a cell growth model and a macroscopic model. Although this methodology and linking framework will be applied to recrystallization, it is also applicable to other types of phase transformations in bulk and layered materials. Critical processes such as the dislocation structure evolution, nucleation, the evolution of crystal orientations into a preferred texture, and grain size evolution all operate at different length scales. In this paper we focus on incorporating experimental measurements of dislocation substructures, rnisorientation measurements of dislocation boundaries, and dislocation simulations into a mesoscopic model of cell growth. In particular, we show how feeding information from the dislocation model into the cell growth model can create realistic initial microstructure.

  6. MODERN MEDIA EDUCATION MODELS

    Directory of Open Access Journals (Sweden)

    Alexander Fedorov

    2011-03-01

    Full Text Available The author supposed that media education models can be divided into the following groups:- educational-information models (the study of the theory, history, language of media culture, etc., based on the cultural, aesthetic, semiotic, socio-cultural theories of media education;- educational-ethical models (the study of moral, religions, philosophical problems relying on the ethic, religious, ideological, ecological, protectionist theories of media education;- pragmatic models (practical media technology training, based on the uses and gratifications and ‘practical’ theories of media education;- aesthetical models (aimed above all at the development of the artistic taste and enriching the skills of analysis of the best media culture examples. Relies on the aesthetical (art and cultural studies theory; - socio-cultural models (socio-cultural development of a creative personality as to the perception, imagination, visual memory, interpretation analysis, autonomic critical thinking, relying on the cultural studies, semiotic, ethic models of media education.

  7. Programming Models in HPC

    Energy Technology Data Exchange (ETDEWEB)

    Shipman, Galen M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-06-13

    These are the slides for a presentation on programming models in HPC, at the Los Alamos National Laboratory's Parallel Computing Summer School. The following topics are covered: Flynn's Taxonomy of computer architectures; single instruction single data; single instruction multiple data; multiple instruction multiple data; address space organization; definition of Trinity (Intel Xeon-Phi is a MIMD architecture); single program multiple data; multiple program multiple data; ExMatEx workflow overview; definition of a programming model, programming languages, runtime systems; programming model and environments; MPI (Message Passing Interface); OpenMP; Kokkos (Performance Portable Thread-Parallel Programming Model); Kokkos abstractions, patterns, policies, and spaces; RAJA, a systematic approach to node-level portability and tuning; overview of the Legion Programming Model; mapping tasks and data to hardware resources; interoperability: supporting task-level models; Legion S3D execution and performance details; workflow, integration of external resources into the programming model.

  8. Foam process models.

    Energy Technology Data Exchange (ETDEWEB)

    Moffat, Harry K.; Noble, David R.; Baer, Thomas A. (Procter & Gamble Co., West Chester, OH); Adolf, Douglas Brian; Rao, Rekha Ranjana; Mondy, Lisa Ann

    2008-09-01

    In this report, we summarize our work on developing a production level foam processing computational model suitable for predicting the self-expansion of foam in complex geometries. The model is based on a finite element representation of the equations of motion, with the movement of the free surface represented using the level set method, and has been implemented in SIERRA/ARIA. An empirically based time- and temperature-dependent density model is used to encapsulate the complex physics of foam nucleation and growth in a numerically tractable model. The change in density with time is at the heart of the foam self-expansion as it creates the motion of the foam. This continuum-level model uses an homogenized description of foam, which does not include the gas explicitly. Results from the model are compared to temperature-instrumented flow visualization experiments giving the location of the foam front as a function of time for our EFAR model system.

  9. Modelling structured data with Probabilistic Graphical Models

    Science.gov (United States)

    Forbes, F.

    2016-05-01

    Most clustering and classification methods are based on the assumption that the objects to be clustered are independent. However, in more and more modern applications, data are structured in a way that makes this assumption not realistic and potentially misleading. A typical example that can be viewed as a clustering task is image segmentation where the objects are the pixels on a regular grid and depend on neighbouring pixels on this grid. Also, when data are geographically located, it is of interest to cluster data with an underlying dependence structure accounting for some spatial localisation. These spatial interactions can be naturally encoded via a graph not necessarily regular as a grid. Data sets can then be modelled via Markov random fields and mixture models (e.g. the so-called MRF and Hidden MRF). More generally, probabilistic graphical models are tools that can be used to represent and manipulate data in a structured way while modeling uncertainty. This chapter introduces the basic concepts. The two main classes of probabilistic graphical models are considered: Bayesian networks and Markov networks. The key concept of conditional independence and its link to Markov properties is presented. The main problems that can be solved with such tools are described. Some illustrations are given associated with some practical work.

  10. Toward the Factory of the Future.

    Science.gov (United States)

    Hazony, Yehonathan

    1983-01-01

    Computer-integrated manufacturing (CIM) involves use of data processing technology as the vehicle for full integration of the total manufacturing process. A prototype research and educational facility for CIM developed with industrial sponsorship at Princeton University is described. (JN)

  11. Modeling agriculture in the Community Land Model

    Directory of Open Access Journals (Sweden)

    B. Drewniak

    2012-12-01

    Full Text Available The potential impact of climate change on agriculture is uncertain. In addition, agriculture could influence above- and below-ground carbon storage. Development of models that represent agriculture is necessary to address these impacts. We have developed an approach to integrate agriculture representations for three crop types – maize, soybean, and spring wheat – into the coupled carbon-nitrogen version of the Community Land Model (CLM, to help address these questions. Here we present the new model, CLM-Crop, validated against observations from two AmeriFlux sites in the United States, planted with maize and soybean. Seasonal carbon fluxes compared well with field measurements. CLM-Crop yields were comparable with observations in some regions, although the generality of the crop model and its lack of technology and irrigation made direct comparison difficult. CLM-Crop was compared against the standard CLM3.5, which simulates crops as grass. The comparison showed improvement in gross primary productivity in regions where crops are the dominant vegetation cover. Crop yields and productivity were negatively correlated with temperature and positively correlated with precipitation. In case studies with the new crop model looking at impacts of residue management and planting date on crop yield, we found that increased residue returned to the litter pool increased crop yield, while reduced residue returns resulted in yield decreases. Using climate controls to signal planting date caused different responses in different crops. Maize and soybean had opposite reactions: when low temperature threshold resulted in early planting, maize responded with a loss of yield, but soybean yields increased. Our improvements in CLM demonstrate a new capability in the model – simulating agriculture in a realistic way, complete with fertilizer and residue management practices. Results are encouraging, with improved representation of human influences on the land

  12. Phyloclimatic modeling: combining phylogenetics and bioclimatic modeling.

    Science.gov (United States)

    Yesson, C; Culham, A

    2006-10-01

    We investigate the impact of past climates on plant diversification by tracking the "footprint" of climate change on a phylogenetic tree. Diversity within the cosmopolitan carnivorous plant genus Drosera (Droseraceae) is focused within Mediterranean climate regions. We explore whether this diversity is temporally linked to Mediterranean-type climatic shifts of the mid-Miocene and whether climate preferences are conservative over phylogenetic timescales. Phyloclimatic modeling combines environmental niche (bioclimatic) modeling with phylogenetics in order to study evolutionary patterns in relation to climate change. We present the largest and most complete such example to date using Drosera. The bioclimatic models of extant species demonstrate clear phylogenetic patterns; this is particularly evident for the tuberous sundews from southwestern Australia (subgenus Ergaleium). We employ a method for establishing confidence intervals of node ages on a phylogeny using replicates from a Bayesian phylogenetic analysis. This chronogram shows that many clades, including subgenus Ergaleium and section Bryastrum, diversified during the establishment of the Mediterranean-type climate. Ancestral reconstructions of bioclimatic models demonstrate a pattern of preference for this climate type within these groups. Ancestral bioclimatic models are projected into palaeo-climate reconstructions for the time periods indicated by the chronogram. We present two such examples that each generate plausible estimates of ancestral lineage distribution, which are similar to their current distributions. This is the first study to attempt bioclimatic projections on evolutionary time scales. The sundews appear to have diversified in response to local climate development. Some groups are specialized for Mediterranean climates, others show wide-ranging generalism. This demonstrates that Phyloclimatic modeling could be repeated for other plant groups and is fundamental to the understanding of

  13. Constitutive models in LAME.

    Energy Technology Data Exchange (ETDEWEB)

    Hammerand, Daniel Carl; Scherzinger, William Mark

    2007-09-01

    The Library of Advanced Materials for Engineering (LAME) provides a common repository for constitutive models that can be used in computational solid mechanics codes. A number of models including both hypoelastic (rate) and hyperelastic (total strain) constitutive forms have been implemented in LAME. The structure and testing of LAME is described in Scherzinger and Hammerand ([3] and [4]). The purpose of the present report is to describe the material models which have already been implemented into LAME. The descriptions are designed to give useful information to both analysts and code developers. Thus far, 33 non-ITAR/non-CRADA protected material models have been incorporated. These include everything from the simple isotropic linear elastic models to a number of elastic-plastic models for metals to models for honeycomb, foams, potting epoxies and rubber. A complete description of each model is outside the scope of the current report. Rather, the aim here is to delineate the properties, state variables, functions, and methods for each model. However, a brief description of some of the constitutive details is provided for a number of the material models. Where appropriate, the SAND reports available for each model have been cited. Many models have state variable aliases for some or all of their state variables. These alias names can be used for outputting desired quantities. The state variable aliases available for results output have been listed in this report. However, not all models use these aliases. For those models, no state variable names are listed. Nevertheless, the number of state variables employed by each model is always given. Currently, there are four possible functions for a material model. This report lists which of these four methods are employed in each material model. As far as analysts are concerned, this information is included only for the awareness purposes. The analyst can take confidence in the fact that model has been properly implemented

  14. Modeling local dependence in longitudinal IRT models

    DEFF Research Database (Denmark)

    Larsen, Maja Olsbjerg; Christensen, Karl Bang

    2015-01-01

    Measuring change in a latent variable over time is often done using the same instrument at several time points. This can lead to dependence between responses across time points for the same person yielding within person correlations that are stronger than what can be attributed to the latent...... variable. Ignoring this can lead to biased estimates of changes in the latent variable. In this paper we propose a method for modeling local dependence in the longitudinal 2PL model. It is based on the concept of item splitting, and makes it possible to correctly estimate change in the latent variable....

  15. Geochemical modeling: a review

    Energy Technology Data Exchange (ETDEWEB)

    Jenne, E.A.

    1981-06-01

    Two general families of geochemical models presently exist. The ion speciation-solubility group of geochemical models contain submodels to first calculate a distribution of aqueous species and to secondly test the hypothesis that the water is near equilibrium with particular solid phases. These models may or may not calculate the adsorption of dissolved constituents and simulate the dissolution and precipitation (mass transfer) of solid phases. Another family of geochemical models, the reaction path models, simulates the stepwise precipitation of solid phases as a result of reacting specified amounts of water and rock. Reaction path models first perform an aqueous speciation of the dissolved constituents of the water, test solubility hypotheses, then perform the reaction path modeling. Certain improvements in the present versions of these models would enhance their value and usefulness to applications in nuclear-waste isolation, etc. Mass-transfer calculations of limited extent are certainly within the capabilities of state-of-the-art models. However, the reaction path models require an expansion of their thermodynamic data bases and systematic validation before they are generally accepted.

  16. Modeling Quantum Well Lasers

    Directory of Open Access Journals (Sweden)

    Dan Alexandru Anghel

    2012-01-01

    Full Text Available In semiconductor laser modeling, a good mathematical model gives near-reality results. Three methods of modeling solutions from the rate equations are presented and analyzed. A method based on the rate equations modeled in Simulink to describe quantum well lasers was presented. For different signal types like step function, saw tooth and sinus used as input, a good response of the used equations is obtained. Circuit model resulting from one of the rate equations models is presented and simulated in SPICE. Results show a good modeling behavior. Numerical simulation in MathCad gives satisfactory results for the study of the transitory and dynamic operation at small level of the injection current. The obtained numerical results show the specific limits of each model, according to theoretical analysis. Based on these results, software can be built that integrates circuit simulation and other modeling methods for quantum well lasers to have a tool that model and analysis these devices from all points of view.

  17. Modelling Farm Animal Welfare.

    Science.gov (United States)

    Collins, Lisa M; Part, Chérie E

    2013-05-16

    The use of models in the life sciences has greatly expanded in scope and advanced in technique in recent decades. However, the range, type and complexity of models used in farm animal welfare is comparatively poor, despite the great scope for use of modeling in this field of research. In this paper, we review the different modeling approaches used in farm animal welfare science to date, discussing the types of questions they have been used to answer, the merits and problems associated with the method, and possible future applications of each technique. We find that the most frequently published types of model used in farm animal welfare are conceptual and assessment models; two types of model that are frequently (though not exclusively) based on expert opinion. Simulation, optimization, scenario, and systems modeling approaches are rarer in animal welfare, despite being commonly used in other related fields. Finally, common issues such as a lack of quantitative data to parameterize models, and model selection and validation are discussed throughout the review, with possible solutions and alternative approaches suggested.

  18. Modelling Farm Animal Welfare

    Directory of Open Access Journals (Sweden)

    Chérie E. Part

    2013-05-01

    Full Text Available The use of models in the life sciences has greatly expanded in scope and advanced in technique in recent decades. However, the range, type and complexity of models used in farm animal welfare is comparatively poor, despite the great scope for use of modeling in this field of research. In this paper, we review the different modeling approaches used in farm animal welfare science to date, discussing the types of questions they have been used to answer, the merits and problems associated with the method, and possible future applications of each technique. We find that the most frequently published types of model used in farm animal welfare are conceptual and assessment models; two types of model that are frequently (though not exclusively based on expert opinion. Simulation, optimization, scenario, and systems modeling approaches are rarer in animal welfare, despite being commonly used in other related fields. Finally, common issues such as a lack of quantitative data to parameterize models, and model selection and validation are discussed throughout the review, with possible solutions and alternative approaches suggested.

  19. 75 FR 59784 - Notice of Fiscal Year 2011 Safety Grants and Solicitation for Applications

    Science.gov (United States)

    2010-09-28

    ... Grants--Carla Vagnini, carla.vagnini@dot.gov , 202- 366-3771. MCSAP High Priority Grants--Cim Weiss, cim...-366-0710. CDLPI Grants--Brandon Poarch, brandon.poarch@dot.gov , 202-366-3030. SaDIP Grants--Cim Weiss, cim.weiss@dot.gov , 202-366-0275. PRISM Grants--Tom Lawler, tom.lawler@dot.gov , 202-366-3866....

  20. Characterization of cytochrome P450 monooxygenases isolated from trichome enriched fraction of Artemisia annua L. leaf.

    Science.gov (United States)

    Misra, Amita; Chanotiya, Chandan S; Gupta, Madan M; Dwivedi, Upendra N; Shasany, Ajit K

    2012-12-01

    CYPs have major role in the biosynthesis and modification of secondary metabolites. Predicting the possible involvement of CYPs in secondary metabolism, 20 partial sequences were amplified from the cDNA of trichome enriched tissue of Artemisia annua. Seven CYPs were converted to full length and assigned to different families based on sequence homology. These were co-expressed with CPR in Saccharomyces cerevisiae and microsome fractions were assayed for conversion of sesquiterpenes, phenols and fatty acid substrates. CIM_CYP02(c73) and CIM_CYP05(c81) converted trans-cinnamic acid to p-coumaric acid; and capric acid, lauric acid to their hydroxylated products, respectively. Higher expression of CIM_CYP71AV1, CIM_CYP03(c72a), CIM_CYP06(c72b), CIM_CYP02(c73) and CIM_CYP04(c83) was observed in the mature leaf, whereas expression of CIM_CYP05(c81) was more in the seedling. CIM_CYP71AV1, CIM_CYP02(c73) and CIM_CYP04(c83) expressed more in the flower bud compared to the leaf, with minor expression in stem. All CYPs' expression increased progressively with time after wounding except for CIM_CYP07(c92). These results relate involvement of CIM_CYP02(c73) to phenyl-propanoid metabolism in the leaf and CIM_CYP05(c81) to fatty acid metabolism in the seedling. Expression of CIM_CYP71AV1 and CIM_CYP02(c73) significantly increased when sprayed with trans-cinnamic acid indicating a relationship between phenylpropanoid and artemisinic acid pathways.