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Sample records for cicatricial retrolental fibroplasia

  1. History of Oxygen Therapy and Retrolental Fibroplasia.

    Science.gov (United States)

    James, L. Stanley, Ed.; Lanman, Jonathan T., Ed.

    1976-01-01

    Presented is a historical report on the use of oxygen therapy with premature infants and the development of retrolental fibroplasia (RLF), a condition leading to detachment of the retina and arrest of growth of the eye. Covered are the following topics: the early history of oxygen use for premature infants (such as for prevention of cyanotic…

  2. Treatment of acute retrolental fibroplasia by cryopexy.

    OpenAIRE

    Ben-Sira, I; Nissenkorn, I; Grunwald, E; YASSUR;, Y.

    1980-01-01

    Fifteen to 20% of premature infants weighing below 1500 g develop variable degrees of acute retrolental fibroplasia (RLF). Approximately 5% of those infants who develop RLF can be expected to become blind. A prospective study was carried out to evaluate if early cryopexy can prevent this blindness. The study showed that, among 533 infants admitted to the neonatal intensive care unit between July 1976 and December 1978, 55 had some degree of active RLF. In 18 eyes of 9 infants in whom the reti...

  3. Cicatricial Alopecia Overview

    Science.gov (United States)

    ... Alopecia Find a Clinical Trial Journal Articles Cicatricial Alopecia Cicatricial Alopecia Overview PDF version of this document [PDF - 170 ... and hair is permanently lost. Who Gets Cicatricial Alopecia? Cicatricial alopecia is not contagious. It occurs worldwide ...

  4. Primary cicatricial alopecia

    OpenAIRE

    Ali Karakuzu

    2014-01-01

    Cicatricial alopecia implies that follicular epithelium has been replaced by connective tissue. In other words cicatricial alopecia might include all forms of alopecia in which all hair follicles are permanently lost. In most of the cases, it is accepted that there is a permanent damage to follicular stem cell. While main target is hair follicle in primary cicatricial alopecia, in secondary cicatricial alopecia hair follicle damage is caused indirectly by a disease that is not in association ...

  5. Central centrifugal cicatricial alopecia

    OpenAIRE

    Collin Blattner; Dennis C Polley; Frank Ferritto; Elston, Dirk M

    2013-01-01

    Central centrifugal cicatricial alopecia is a common cause of progressive permanent apical alopecia. This unique form of alopecia includes entities previously know as “hot comb alopecia,” “follicular degeneration syndrome,” “pseudopelade” in African Americans and “central elliptical pseudopelade” in Caucasians. The etiology appears to be multifactorial and the condition occurs in all races.

  6. Dermoscopic findings in cicatricial alopecia

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    Seher Arı

    2013-12-01

    Full Text Available Background: Dermoscopy is an important tool for the diagnosis of pigmented skin lesions. Newly, this method has also been used in the diagnosis and follow-up hair and scalp disorders. Objective: The objective of this study was to investigate dermoscopic findings in a sample of patients with clinical and histopathological compatible with cicatricial alopecia. Methods: Twenty nine patients with cicatricial alopecia diagnosed by clinical and histological findings were examined by dermoscopy.. Results: Dermoscopic features evaluated included folliculitis decalvans (n=8, pseudopelade of Brocq (n=7, lichen planopilaris (n=6, discoid lupus erythematosus (n=2, dissecting cellulitis (n=1, and secondary cicatricial alopecia (n=5. Visualization of structures previously examined with naked eye were seen in great detail with dermoscopy. The loss of follicular orifices was seen in all patients with cicatricial alopecia. Perifollicular scaling, arborizing red lines, honeycomb pigment pattern, white dots and tufted hairs were the other most obvious findings. Conclusion: Use of dermoscopy in the clinical evaluation of cicatrical alopecia improves diagnostic capability beyond simple clinic inspection, but larger studies correlating dermoscopic findings with histopathology exams are needed to improve understanding of this method.

  7. Cicatricial Ectropion Secondary to Psoriatic Arthritis

    Science.gov (United States)

    Gracitelli, Carolina P. B.; Osaki, Tammy Hentona; Valdrighi, Natalia Yumi; Viana, Giovanni André Pires; Osaki, Midori Hentona

    2015-01-01

    Ectropion is characterized by the eversion of the eyelid margin and the consequent exposure of the conjunctiva and cornea. The shortening of the anterior lamella of the lid causes cicatricial ectropion. We described a case of skin pathology causing cicatricial ectropion. The case is about a 68-year-old woman with a 2-year history of psoriatic arthritis. She complained of eyelid tearing and redness for two years. Due to the psoriasis, she presented a very dry skin, also in the periocular region, resulting in cicatricial ectropion. A skin graft was indicated to correct the eyelid malposition. Careful investigation should be performed in patients who have a skin disease that can lead to cicatricial ectropion. PMID:25810938

  8. Cicatricial Ectropion Secondary to Psoriatic Arthritis

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    Carolina P. B. Gracitelli

    2015-01-01

    Full Text Available Ectropion is characterized by the eversion of the eyelid margin and the consequent exposure of the conjunctiva and cornea. The shortening of the anterior lamella of the lid causes cicatricial ectropion. We described a case of skin pathology causing cicatricial ectropion. The case is about a 68-year-old woman with a 2-year history of psoriatic arthritis. She complained of eyelid tearing and redness for two years. Due to the psoriasis, she presented a very dry skin, also in the periocular region, resulting in cicatricial ectropion. A skin graft was indicated to correct the eyelid malposition. Careful investigation should be performed in patients who have a skin disease that can lead to cicatricial ectropion.

  9. Incising the thick retrolental fibrovascular tissue with a hooked sclerotome in persistent hyperplastic primary vitreous.

    Science.gov (United States)

    Shiraki, K; Moriwaki, M; Kohno, T; Yanagihara, N; Miki, T

    1999-01-01

    A technique for incising thick retrolental fibrovascular tissue and extensive cyclitic membrane is reported in a case of anterior persistent hyperplastic primary vitreous. A membranectomy was performed in a 1-month-old post-lensectomy baby via a limbal approach. A sclerotome tip was hooked to cut through an extremely thick fibrovascular tissue by rotating the sclerotome by its grip. Sutherland microscissors (Grieshaber, Switzerland) and a vitrectomy cutter were used for further membranectomy. The baby was followed-up until age 18 months. A total of 3 membranectomy sessions were required because of rapid cyclitic membrane formation, severe centripetal retraction of the membrane on the ciliary processes, and posterior synechia. Thorough membranectomy and cutting the iris edge maintained a clear pupillary area during the 13-month postoperative period. Extremely thick retrolental fibrovascular tissue is a challenging condition that can be dealt with by delicate instrumentation. PMID:10574499

  10. Grade of Atypia in Dysplastic Nevi and Relationship with Dermal Fibroplasia

    OpenAIRE

    Ahmet BABACAN; Banu LEBE

    2012-01-01

    Objective: Dysplastic nevus is described as an important factor in increasing the risk of melanoma. Many authors suggested dysplastic nevi should be graded according to architectural and cytological features. Dermal fibroplasia can be in concentric or lamellar fashion. In our study we aim to grade architectural and cytological atypia in dysplastic nevi and to assess the relationship between atypia and dermal fibroplasia.Material and Method: Ninety-three biopsies obtained from 71 patients were...

  11. Slow-Release Drug Deliver System with Polylactic Acid Hydrogels in Prevention of Tracheal Wall Fibroplasia

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    Jinrang Li

    2012-02-01

    Conclusions: Both MMC/PLA and DSP/PLA hydrogels can inhibit fibroplasia of the tracheal wall and it can be coated in a Poly L-lactide-co and ndash;glycolide (PLGA scaffold for treating laryngeal-tracheal stenosis in future. [Arch Clin Exp Surg 2012; 1(1.000: 1-7

  12. Ocular cicatricial pemphigoid masquerading as chronic conjunctivitis: a case report

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    DaCosta J

    2012-12-01

    Full Text Available Joanna DaCostaMoorfields Eye Hospital, London, UKAbstract: Conjunctivitis is often considered an innocuous condition which is self-limiting. This report describes misdiagnosis of ocular cicatricial pemphigoid as chronic conjunctivitis. Ocular cicatricial pemphigoid is a rare autoimmune condition. The clinical features which are useful to distinguish this condition from infective conjunctivitis are discussed. The investigation and treatment of ocular cicatricial pemphigoid is discussed. It is important to recognize nonocular symptoms and signs that may indicate the presence of a more serious underlying pathological condition necessitating specialized ophthalmic referral and subsequent investigation and treatment.Keywords: autoimmune, conjunctivitis, ocular cicatricial pemphigoid

  13. Central centrifugal cicatricial alopecia: challenges and solutions.

    Science.gov (United States)

    Herskovitz, Ingrid; Miteva, Mariya

    2016-01-01

    Central centrifugal cicatricial alopecia (CCCA) is the most common scarring alopecia among African American women. Data about epidemiology, etiology, genetic inheritance, and management are scarce and come from individual reports or small series. CCCA has been associated with hot combing and traumatic hair styling for years; however, studies fail to confirm it as the sole etiologic factor. It has been shown in a small series that CCCA can be inherited in an autosomal dominant fashion, with a partial penetrance and a strong modifying effect of hairstyling and sex. CCCA presents clinically as a central area of progressive irreversible hair loss that expands to the periphery. A patchy form has also been described. Dermoscopy is helpful to identify the optimal site for the biopsy, which establishes the diagnosis. Well-designed randomized controlled trials are needed to discover the optimal management. At this point, patients are advised to avoid traction and chemical treatments; topical and intralesional steroids, calcineurin inhibitors, and minoxidil can be helpful in halting the progression. PMID:27574457

  14. Central centrifugal cicatricial alopecia: challenges and solutions.

    Science.gov (United States)

    Herskovitz, Ingrid; Miteva, Mariya

    2016-01-01

    Central centrifugal cicatricial alopecia (CCCA) is the most common scarring alopecia among African American women. Data about epidemiology, etiology, genetic inheritance, and management are scarce and come from individual reports or small series. CCCA has been associated with hot combing and traumatic hair styling for years; however, studies fail to confirm it as the sole etiologic factor. It has been shown in a small series that CCCA can be inherited in an autosomal dominant fashion, with a partial penetrance and a strong modifying effect of hairstyling and sex. CCCA presents clinically as a central area of progressive irreversible hair loss that expands to the periphery. A patchy form has also been described. Dermoscopy is helpful to identify the optimal site for the biopsy, which establishes the diagnosis. Well-designed randomized controlled trials are needed to discover the optimal management. At this point, patients are advised to avoid traction and chemical treatments; topical and intralesional steroids, calcineurin inhibitors, and minoxidil can be helpful in halting the progression.

  15. Central centrifugal cicatricial alopecia: challenges and solutions

    Directory of Open Access Journals (Sweden)

    Herskovitz I

    2016-08-01

    Full Text Available Ingrid Herskovitz, Mariya Miteva Department of Dermatology and Cutaneous Surgery, University of Miami L Miller School of Medicine, Miami, FL, USA Abstract: Central centrifugal cicatricial alopecia (CCCA is the most common scarring alopecia among African American women. Data about epidemiology, etiology, genetic inheritance, and management are scarce and come from individual reports or small series. CCCA has been associated with hot combing and traumatic hair styling for years; however, studies fail to confirm it as the sole etiologic factor. It has been shown in a small series that CCCA can be inherited in an autosomal dominant fashion, with a partial penetrance and a strong modifying effect of hairstyling and sex. CCCA presents clinically as a central area of progressive irreversible hair loss that expands to the periphery. A patchy form has also been described. Dermoscopy is helpful to identify the optimal site for the biopsy, which establishes the diagnosis. Well-designed randomized controlled trials are needed to discover the optimal management. At this point, patients are advised to avoid traction and chemical treatments; topical and intralesional steroids, calcineurin inhibitors, and minoxidil can be helpful in halting the progression. Keywords: hair loss, alopecia, dermatoscopy, dermoscopy, trichoscopy, black scalp, African American, scarring alopecia

  16. Differentiating Central Centrifugal Cicatricial Alopecia and Androgenetic Alopecia in African American Men: Report of Three Cases

    OpenAIRE

    Davis, Erica C.; Reid, Sophia D.; Callender, Valerie D.; Sperling, Leonard C.

    2012-01-01

    Central centrifugal cicatricial alopecia is a scarring alopecia that is predominantly seen in African American women, but occurs less frequently in men. The authors present three cases of African American men with biopsy-proven central centrifugal cicatricial alopecia and detail the clinical presentation, histological findings, and treatment regimens. Central centrifugal cicatricial alopecia should be considered in the differential diagnosis when evaluating male patients with vertex hair loss...

  17. Etiology of cicatricial alopecias: a basic science point of view.

    Science.gov (United States)

    McElwee, Kevin J

    2008-01-01

    This article presents a short summary of our current knowledge of cicatricial alopecia disease pathogenesis and the hypothetical disease mechanisms that may be involved in scarring alopecia development. Several forms of scarring alopecia likely involve targeted cytotoxic action against hair follicle cells mediated by a folliculocentric inflammation. However, the specific nature of the inflammatory interference in hair follicle growth is open to question. A popular hypothesis of lymphocyte-mediated scarring alopecia development involves autoimmune targeting of hair follicle-specific self-antigens, although there is no direct evidence in support of such a view. Alternative hypotheses focus on defects in sebaceous gland function, destruction of hair follicle stem cells, and interference in the communication between hair follicle mesenchyme and epithelium. Many questions arise from these hypotheses, and addressing them with a systematic research approach may enable significant advances in understanding cicatricial alopecia etiology.

  18. Etiology of cicatricial alopecias: a basic science point of view.

    Science.gov (United States)

    McElwee, Kevin J

    2008-01-01

    This article presents a short summary of our current knowledge of cicatricial alopecia disease pathogenesis and the hypothetical disease mechanisms that may be involved in scarring alopecia development. Several forms of scarring alopecia likely involve targeted cytotoxic action against hair follicle cells mediated by a folliculocentric inflammation. However, the specific nature of the inflammatory interference in hair follicle growth is open to question. A popular hypothesis of lymphocyte-mediated scarring alopecia development involves autoimmune targeting of hair follicle-specific self-antigens, although there is no direct evidence in support of such a view. Alternative hypotheses focus on defects in sebaceous gland function, destruction of hair follicle stem cells, and interference in the communication between hair follicle mesenchyme and epithelium. Many questions arise from these hypotheses, and addressing them with a systematic research approach may enable significant advances in understanding cicatricial alopecia etiology. PMID:18715290

  19. Follicular unit transplantation for the treatment of secondary cicatricial alopecia

    OpenAIRE

    SHAO, HUAWEI; Hang, Hu; Yunyun, Jin; Hongfei, Jiang; Chunmao, Han; Zhang, Jufang; Shen, Haiyan; Zhu, Fei; Jia, Ming; Wang, Yuyan; Guo, Xiaobo

    2014-01-01

    Cicatricial alopecia, secondary to burns, trauma, surgery or radiation, describes a diverse group of disorders characterized by follicular destruction and permanent hair loss. Although surgical treatments for the condition are available, they often result in unfavourable scarring or hair growth direction. Although not yet validated in large clinical trials, follicular unit transplantation has shown promise. The authors of this Chinese study describe their experience with the technique perform...

  20. Cicatricial Pemphigoid in Accompany with Rheumatoid Arthritis: a Case Report

    Institute of Scientific and Technical Information of China (English)

    Di Wu; Li-ming Zhang; Ying Jiang

    2010-01-01

    @@ CICATRICIAL pemphigoid (CP, also known as benign mucous membrane pemphigoid) is a rare chronic autoimmune subepithelial blister-ing disease, with an incidence of 1 per million, characterized by erosive lesions of mucous membranes and skin that result in scarring.1,2 Rheumatoid arthritis (RA) is a symmetric inflammatory arthritis that mainly affects the small joints of hands and feet, with a prevalence of 0.3% in China. In this case report we described the diagnosis of and treatment for a patient developing CP 18 years after the onset of RA, a combination rarely en-countered or reported so far.

  1. Clinical features of primary cicatricial alopecia in Chinese patients

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    Shiling Qi

    2014-01-01

    Full Text Available Background: There have been few reports on primary cicatricial alopecias (PCR especially from Asia (PCA. Aims: To study the clinical, pathological and dermoscopic characteristics of PCA among Chinese patients. Methods: A retrospective analysis of the clinical data of 59 patients with PCA was conducted and the dermoscopic, pathological, treatment and prognosis characteristics analyzed. Fisher′s Chi-square exact test, Kruskal-Wallis and Spearman rank correlation test were performed. Results: The ratio of neutrophilic to lymphocytic cicatricial alopecias was about 1.3:1 in this group. The most frequent disorder was folliculitis decalvans. Follicular openings were absent on dermoscopy in all cases except alopecia mucinosa. Patulous follicular openings were characterisitc of alopecia mucinosa. After treatment, an increase in short vellus hairs was the earliest feature, while telangiectasia, epidermal scale, follicular hyperkeratosis, pustules and hair diameter diversity gradually decreased or even disappeared. Improvement in the areas of hair loss after treatment was seen more often in discoid lupus erythematosus, folliculitis decalvans and dissecting cellulitis than in patients with classic pseudopelade of Brocq. Nine patients (13.6% relapsed after cessation of therapy. Female patients needed longer treatment times. Long duration, large areas of hair loss and shorter treatment courses were the major factors in relapses. Conclusions: Dermatoscopy provides a rapid, practical and useful aid for the diagnosis of PCA and also to assess disease activity. Patulous follicular openings are a specific dermoscopic sign of alopecia mucinosa. Lichen planopilaris is less common in China than in the West.

  2. Is seborrhoeic dermatitis associated with a diffuse, low-grade folliculitis and progressive cicatricial alopecia?

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    Pitney, Lucy; Weedon, David; Pitney, Michael

    2016-08-01

    An association between adult scalp seborrhoeic dermatitis and cicatricial hair loss has not previously been convincingly established. This study seeks to demonstrate a unique relationship between a clinically identifiable chronic scalp dermatitis-folliculitis with the characteristic histological features of low-grade inflammatory fibrosing alopecia, resulting in a distinctive progressive cicatricial alopecia which we believe is prevalent and hitherto unrecognised, and befits the description of seborrhoeic folliculitis. The clinical, epidemiological and histopathological features of seborrhoeic folliculitis are demonstrated to establish its unique status among the disorders of adult diffuse cicatricial alopecia. PMID:25753934

  3. Penfigóide cicatricial no trato aerodigestivo superior: relato de dois casos Cicatricial pemphygoid in the upper aerodigestive tract: report of two cases

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    Vinicius Antunes Freitas

    2008-12-01

    Full Text Available Penfigóide Cicatricial (Penfigóide Cicatricial de Membrana Mucosa é uma doença auto-imune inflamatória crônica caracterizada pela presença de bolhas subepiteliais em membranas mucosas e, ocasionalmente na pele. Pode haver acometimento oral, nasal, faríngeo, laríngeo, ocular, esofágico, anogenital e de pele, predominantemente em pacientes na quinta e sexta décadas de vida. O tratamento preconizado inclui corticóides sistêmicos e agentes imunossupressores. Descrevemos neste trabalho dois casos com a doença em atividade, sendo que um evoluiu com complicação séptica pelo uso de imunossupressor e outro que apresentou estenose supraglótica exigindo traqueotomia.Cicatricial pemphygoid (mucous membrane cicatricial pemphygoid is a chronic autoimmune inflammatory disease characterized by subepithelial bubbles in mucous membranes and, occasionally on the skin. It may affect the mouth, the nose, pharynx, larynx, the eyes, esophagus, anus, genitals and skin; especially affecting patients between fifty and sixty years of life. Treatment includes systemic steroids and immunosuppressive agents. In the present paper we describe two cases with the active disease, and one of them had sepsis because of using immunosuppressive agents and another that presented supraglottic stenosis requiring tracheostomy.

  4. Central centrifugal cicatricial alopecia amalgamated with alopecia areata: immunologic findings

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    Ana Maria Abreu Velez

    2014-07-01

    Full Text Available Introduction: Both scarring and non-scarring alopecias exist; however, rare cases demonstrate features of both classes. Case Report: We describe an interesting alopecia case with amalgamated clinical, histologic and immunopathologic features of scarring and non-scarring alopecia. Specifically, the case displays combined features of alopecia areata (AA and of central centrifugal cicatricial alopecia (CCCA. A 36 year old female presented with symmetric, round, patchy hair loss on her scalp. Methods: Biopsies for hematoxylin and eosin (H&E examination, as well as for special stains, direct immunofluorescence (DIF and immunohistochemistry (IHC were performed. Results: The H&E biopsy revealed focally diminished hair follicular units, and sebaceous gland damage. Perifollicular concentric fibrosis was confirmed by Verhoeff elastin special staining. Antibodies to micelles were noted. Positive IHC staining for CD4, CD8, CD45 and multiple proteases and protease inhibitors was noted around selected follicular unit remnants. Conclusion: We present a rare alopecia, combining histologic features of CCCA with additional, selected immunologic features of AA.

  5. Central centrifugal cicatricial alopecia: what has been achieved, current clues for future research.

    Science.gov (United States)

    Ogunleye, Temitayo A; McMichael, Amy; Olsen, Elise A

    2014-04-01

    Central centrifugal cicatricial alopecia is an inflammatory type of central scalp hair loss seen primarily in women of African descent. The prevalence is unknown, but may vary from 2.7% to 5.7% and increases with age. This review outlines the history and current beliefs and identifies clues for future research for this enigmatic condition. Despite that the cause of central centrifugal cicatricial alopecia is unknown, research is ongoing. The role of cytokeratins, androgens, genetics, and various possible sources of chronic inflammation in disease pathogenesis remain to be elucidated.

  6. Antiepiligrin cicatricial pemphigoid of the larynx successfully treated with a combination of tetracycline and niacinamide.

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    Sakamoto, Kikuo; Mori, Kazunori; Hashimoto, Takashi; Yancey, Kim B; Nakashima, Tadashi

    2002-12-01

    A case of antiepiligrin cicatricial pemphigoid that primarily involved the larynx and required a tracheostomy was studied. The diagnosis was based on the direct immunofluorescence findings of a biopsy specimen from the glottis, immunofluorescence using normal and 1M sodium chloride-split normal human skin as substrates, and immunoprecipitation. A dramatic clinical improvement was observed after the combined administration of tetracycline hydrochloride and niacinamide. The tracheal stoma could be shut after the narrow segment was cut by means of carbon dioxide laser therapy. The patient showed no respiratory difficulty during the 2-year follow-up period. The combined therapy of tetracycline and niacinamide is thus considered to be an effective treatment for various types of cicatricial pemphigoid.

  7. TGF-β1 induces an age-dependent inflammation of nerve ganglia and fibroplasia in the prostate gland stroma of a novel transgenic mouse.

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    David A Barron

    Full Text Available TGF-β1 is overexpressed in wound repair and in most proliferative disorders including benign prostatic hyperplasia and prostate cancer. The stromal microenvironment at these sites is reactive and typified by altered phenotype, matrix deposition, inflammatory responses, and alterations in nerve density and biology. TGF-β1 is known to modulate several stromal responses; however there are few transgenic models to study its integrated biology. To address the actions of TGF-β1 in prostate disorders, we targeted expression of an epitope tagged and constitutively active TGF-β1 via the enhanced probasin promoter to the murine prostate gland epithelium. Transgenic mice developed age-dependent lesions leading to severe, yet focal attenuation of epithelium, and a discontinuous basal lamina. These changes were associated with elevated fibroplasia and frequency of collagenous micronodules in collapsed acini, along with an induced inflammation in nerve ganglia and small vessels. Elevated recruitment of CD115+ myeloid cells but not mature macrophages was observed in nerve ganglia, also in an age-dependent manner. Similar phenotypic changes were observed using a human prostate epithelium tissue recombination xenograft model, where epithelial cells engineered to overexpress TGF-β1 induced fibrosis and altered matrix deposition concurrent with inflammation in the stromal compartment. Together, these data suggest that elevated TGF-β1 expression induces a fibroplasia stromal response associated with breach of epithelial wall structure and inflammatory involvement of nerve ganglia and vessels. The novel findings of ganglia and vessel inflammation associated with formation of collagenous micronodules in collapsed acini is important as each of these are observed in human prostate carcinoma and may play a role in disease progression.

  8. Suspensão subperiostal do terço médio da face: uma alternativa para correção do ectrópio cicatricial Subperiosteal midfacelift: an alternative to correct the cicatricial eyelid ectropion

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    Silvana Artioli Schellini

    2005-08-01

    Full Text Available OBJETIVO: Apresentar a elevação subperiostal do terço médio da face como uma alternativa para o tratamento do ectrópio cicatricial da pálpebra inferior. MÉTODOS: Doze cirurgias foram feitas em 9 pacientes, estudados quanto ao sexo e os resultados do procedimento. Todos os pacientes foram operados com anestesia local, tendo o terço médio da face reposicionado por suturas. O tempo de seguimento foi de 6 meses. RESULTADOS: Foram obtidos bons resultados, com poucas complicações, exceto em duas pálpebras operadas que continuaram com ectrópio. CONCLUSÃO: O "midface lift" subperiostal é uma boa alternativa para correção do ectrópio cicatricial.PURPOSE: To show the subperiosteal midface lift as an option to treat cicatricial eyelid ectropion. METHODS: Nine patients submitted to 12 surgeries to correct cicatricial eyelid ectropion, were evaluated according sex, age and treatment results. All the patients had the surgery done under local anesthesia and the midface was repositioned by sutures. RESULTS: According to our observations only two eyelids did not have good improvement with the procedure and few complications occurred. CONCLUSION: The subperiostal midface lift is effective and a good option to correct the cicatricial eyelid ectropion.

  9. Esophageal Cicatricial Pemphigoid as an Isolated Involvement Treated with Mycophenolate Mofetil

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    Sandra Sánchez Prudencio

    2015-01-01

    Full Text Available Cicatricial pemphigoid (CP is a rare blistering autoimmune disease. Esophageal involvement occurs in widespread disease and rarely appears as the only affected organ. We report a 67-year-old Caucasian female with esophageal dysphagia and weight loss. Several oral panendoscopies showed multiple exudative ulcerations with fibrin and webs in mid- and proximal esophagus and a peeling mucosa. There were no lesions in other organs. We established the diagnosis performing a direct immunofluorescence (DIF, demonstrating IgG3 and complement deposition along the basement membrane. As initial treatment the patient received prednisone 60 mg and 1 gr twice daily of mycophenolate mofetil (MMF as a steroid-sparing agent due to its lower toxicity and its selective mechanism of action. Six months later there was a significant clinical improvement and the esophageal ulcerations had disappeared, developing cicatricial fibrous rings, although no stenosis was present. Four years later, the patient remains asymptomatic with a low maintenance dose of MMF.

  10. Upper eyelid entropion and dry eye in cicatricial trachoma without trichiasis

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    Abrahão Lucena

    2012-12-01

    Full Text Available PURPOSE: to evaluate the position of the upper eyelid margin and eye surface status in cicatricial trachoma without trichiasis (TS. METHODS: Slit-lamp biomicroscopy was employed to evaluate the location of the upper lid mucocutaneous transition of 156 eyes of 78 patients with trichiasis and of 130 eyes of 65 control subjects. For each eye the position of the upper lid mucocutaneous junction was graded with respect to the line of meibomian gland orifices into 3 categories: a anterior, b at the line, and c posterior to the line. Ocular surface dye staining with lissamine green was performed in all eyes. All participants answered a questionnaire with queries on the presence and intensity of dry eye symptoms. RESULTS: In the eyes with trichiasis the location of the mucocutaneous transition was posterior to the meibomian gland line in 55 (35.3%, at the line in 77 (49.4% and anterior to the line in only 24 (15.4%. In the control group these figures were: 5 (3.8%; 42 (42% and 83 (63.8%. Lissamine staining and dry eye symptoms were also associated with trichiasis. CONCLUSION: Different degrees of upper lid entropion are already present in cicatricial trachoma even in the absence of trichiasis. Trichiasis is associated with lissamine green staining and dry eye symptoms. Conjunctivalization of the upper lid margin may play a role in the development of trachomatous dry eye.

  11. Potencial cicatricial da Bixa orellana L. em feridas cutâneas: estudo em modelo experimental

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    S.O. Capella

    2016-02-01

    Full Text Available O uso de fitoterápicos é uma alternativa de baixo custo e de fácil acesso para o tratamento de feridas cutâneas. Objetivou-se avaliar a ação do extrato oleoso de urucum na cicatrização de feridas cutâneas abertas. Inicialmente, identificaram-se os principais ácidos graxos do óleo de urucum. Foi realizado ensaio citotóxico para determinar as concentrações a serem utilizadas no ensaio in vivo. No experimento, feridas cutâneas em ratos Wistar foram diariamente tratadas com: extrato de urucum 0,1% (U 0,1%, extrato de urucum 0,01% (U 0,01%, vaselina (V e solução fisiológica (SF, por até 21 dias. Aos quatro, sete, 14 e 21 dias, foi avaliada clinicamente a presença de exsudato, crosta e epitelização. Determinaram-se as áreas da lesão, e amostras de pele, fígado e rins foram coletadas para avalição histológica. Aos 21dias, amostras de pele foram coletadas para análise tensiométrica. Clinicamente, todos os grupos de tratamento apresentaram evolução cicatricial fisiológica. Os grupos U 0,1% e U 0,01% apresentaram maior presença de epitelização aos sete dias e maior retração cicatricial aos quatro dias. Na histologia, U 0,1% e U 0,01% apresentaram aos quatro e sete dias maior quantidade de fibrina e inflamação que V e SF, e, nos demais momentos, não houve diferenças entre os grupos. Quanto à fase cicatricial, aos quatro dias todos os grupos encontravam-se na fase inflamatória, aos sete dias U 0,1% e U 0,01% permaneciam na fase inflamatória, diferindo de SF e V, que se caracterizavam na fase proliferativa. Aos 14 dias, os grupos apresentavam-se em transição de fase proliferativa para maturação e, aos 21dias, estavam todos na fase de maturação. Os grupos tratados com urucum expressaram menor resistência à tensão que V e SF. Concluiu-se com este estudo que o extrato oleoso de urucum acelera o processo cicatricial nos primeiros dias, mas proporciona uma cicatriz de baixa qualidade.

  12. Cicatricial ectropion correction in a patient with pyoderma gangrenosum: case report.

    Science.gov (United States)

    Procianoy, Fernando; Barbato, Mariana Tremel; Osowski, Luiz Eduardo; Bocaccio, Francisco José de Lima; Bakos, Lucio

    2009-01-01

    A 19 year old female with pyoderma gangrenosum was referred to the oculoplastic clinic for evaluation of severe cicatricial ectropion of the right lower eyelid. Examination evidenced important scarring of lower eyelid and malar region with secondary ectropion. A full-thickness skin graft associated with a lateral tarsal strip procedure and scar tissue release was performed. The patient's corticosteroid dose was raised for the procedure, and after surgery there was no healing problem or ulcer formation in the eyelid or in the graft donor site. As pyoderma gangrenosum is associated with a pathergy phenomenon in up to 25% of the cases, the onset of new lesions is a relevant concern when performing surgery in these patients. In this case, the surgery was safely performed under corticosteroid immunosuppression.

  13. Cicatricial Pemphigoid

    Science.gov (United States)

    ... several ways to treat pemphigoid, including tetracycline with niacinamide, cortisone-type drugs that suppress the immune reaction, ... Another alternative is the use of tetracycline and niacinamide, taking one capsule of each, four times daily. ...

  14. Association of DQw7 (DQB1*0301) with ocular cicatricial pemphigoid.

    Science.gov (United States)

    Ahmed, A R; Foster, S; Zaltas, M; Notani, G; Awdeh, Z; Alper, C A; Yunis, E J

    1991-01-01

    Ocular cicatricial pemphigoid (OCP) is an autoimmune blistering disease that affects the conjunctiva and multiple mucous membranes. Class I and II and complement genetic markers of the major histocompatibility complex were studied in 20 Caucasian OCP patients and members of their families. Frequencies of individual alleles and common fixed or extended haplotypes in the patients were compared with those in normal family control haplotypes and with overall normal Caucasian haplotypes. The most striking increase compared with overall controls was noted in HLA-DQw3 (P = 0.006), unassociated with any extended haplotype. All but 1 of the 20 patients carried DQw3 in linkage with HLA-DR4 (increased significantly with P = 0.042 compared with overall normal genotype controls) or DR5. The DQw3, on analysis by restriction fragment length polymorphism in genomic DNA, was, in every instance, DQw7 (3.1, DQB1*0301). The frequency of DQB1*0301 in patient haplotypes compared with overall normal DR4 and DR5 DQw3-bearing haplotypes was statistically significantly increased (P less than 0.003, relative risk = 9.6). The distribution of homozygotes and heterozygotes for DQB1*0301 among the patients was consistent with dominant but not recessive inheritance of DQB1*0301 or a gene, probably a class II allele, in linkage disequilibrium with it as the major histocompatibility complex susceptibility gene for OCP. Images PMID:1763074

  15. Ceratoconjuntivite cicatricial bilateral associada a líquen plano: relato de caso Lichen planus leading to bilateral cicatrizing keratoconjunctivitis: case report

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    Camila Melo Gadelha Pereira Diniz

    2008-12-01

    Full Text Available Descrevemos um caso de ceratoconjuntivite cicatricial bilateral em uma paciente portadora de líquen plano e apresentamos revisão da literatura mundial sobre esse assunto. Cicatrização conjuntival, com formação de simbléfaro, olho seco, infiltração corneana, neovascularização e afinamento foram os sinais observados. Diagnóstico foi baseado nos achados clínicos e biópsia, após exclusão das causas típicas de ceratoconjuntivite cicatricial.To describe a case of bilateral cicatrizing keratoconjunctivitis in a patient with lichen planus and review the literature. Conjunctiva cicatrization with symblepharon formation, dry eye, corneal infiltration and neovascularization and thinning were the most observed prominent signs. Diagnosis was based on clinical findings and biopsy, after exclusion of typical causes of cicatricial keratoconjuntivitis.

  16. Upper lid crease approach for margin rotation in trachomatous cicatricial entropion without external sutures

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    Antonio Augusto Velasco e Cruz

    2015-12-01

    Full Text Available ABSTRACT Purpose: To describe the use of a lid crease incision for upper eyelid margin rotation in cicatricial entropion combining internal traction on the anterior lamella, tarsotomy, and tarsal overlap without external sutures. Methods: Surgical description: The main steps of the procedure consisted of exposure of the entire tarsal plate up to the eyelashes followed by tarsotomy through the conjunctiva. A double-armed 6.0 polyglactin suture was then passed through the distal tarsal fragment to the marginal section of the orbicularis oculi muscle. As the sutures were tied, the distal tarsus advanced over the marginal section, and traction was exerted on the marginal strip of the orbicularis muscle. There were no bolsters or external knots. The pretarsal skin-muscle flap was closed with a 6.0 plain gut suture. Results: We used this procedure at a tertiary hospital in Saudi Arabia from 2013 to 2014. Sixty upper lids of 40 patients (23 women and 17 men were operated on, with an age range of 44-99 years [mean ± standard deviation (SD = 70.9 ± 13.01 years]. Bilateral surgery was performed on 21 patients. Follow-up ranged from 1 to 12 months (mean 3.0 ± 2.71 months. Forty percent of the patients (24 lids had more than 3 months' follow-up. The postoperative lid margin position was good in all cases. Trichiasis (two lashes was observed in only one patient with unilateral entropion on the medial aspect of the operated lid. Conclusions: The upper lid margin can be effectively rotated through a lid crease incision with internal sutures. The technique combines the main mechanisms of the Wies and Trabut approaches and avoids the use of bolsters or external sutures, which require a second consultation to be removed. Some other lid problems, such as ptosis, retraction, or dermatochalasis, can be concomitantly addressed during the procedure.

  17. Imunofluorescência direta no diagnóstico de casos suspeitos de penfigóide cicatricial ocular

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    Donato Waleska Belmino Chaves

    2003-01-01

    Full Text Available OBJETIVOS: O objetivo deste estudo é caracterizar por meio do exame oftalmológico os pacientes com suspeita clínica de penfigóide cicatricial ocular e apresentar os resultados obtidos com a técnica de imunofluorescência direta. MÉTODOS: Estudo prospectivo realizado no setor de Córnea e Doenças Externas da Universidade Federal de São Paulo. Foram examinados 18 pacientes com suspeita clínica de penfigóide cicatricial ocular e realizadas biópsias de conjuntiva para o processamento da imunofluorescência direta em 13 pacientes (26 olhos, que não estavam na vigência de imunossupressão sistêmica ou terapêutica antiglaucomatosa tópica. RESULTADOS: Segundo o estadiamento de Foster, a proporção de olhos classificados de I a IV foram: 3,8%, 3,8%, 77%, 15,4% respectivamente. Apenas 3 (23% pacientes apresentaram imunofluorescência direta positiva. CONCLUSÃO: A maioria dos pacientes encontravam-se em estágio avançado da doença, o que denota retardo no diagnóstico. A imunofluorescência direta apresentou baixa sensibilidade em detectar depósitos de imunocomplexos na membrana basal da conjuntiva, quando comparada aos dados da literatura.

  18. 小儿手烧伤瘢痕畸形的整形外科治疗%Plastic surgery treatment on cicatricial deformation in child burn of hand

    Institute of Scientific and Technical Information of China (English)

    葛乃航; 朱云

    2002-01-01

    Background: Cicatricial deformation in child burn of hand often leads to severe squaelae. According to different causes of disease , different plastic surgery were adopted .The key of operation lies in skin repairing , articulation dealing, and thumb correcting, which aim is to resume normal longitudinal and transverse arcs ,holding and clenching ability.

  19. Tratamiento sistémico del penfigoide cicatrizal ocular Systemic treatment of ocular cicatricial pemphigoid

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    María Cecilia Juri

    2012-04-01

    Full Text Available El penfigoide cicatrizal ocular (PCO es una enfermedad ampollar autoinmune que produce daño conjuntival grave. Se conoce poco acerca de la respuesta del PCO al tratamiento inmunosupresor. Describimos un grupo de 76 pacientes con PCO, 62 mujeres y 14 hombres. La edad media al diagnóstico fue de 67 ± 14 años, con un retraso de 7.5 ± 10 años. Sesenta se siguieron en nuestro servicio por 19 ± 21 meses. De 51 en quienes se describe la gravedad de la enfermedad al inicio del tratamiento, fue leve en 19 pacientes, moderada en 19, grave en cinco y muy grave en ocho. Las drogas mayormente prescriptas fueron dapsona en 35 pacientes, de los que 23 la discontinuaron por efectos adversos, y metotrexate en 42, de los que nueve lo suspendieron. Otros recibieron azatioprina, ciclofosfamida y ciclosporina. A 17 se les indicaron corticoides orales, además del inmunosupresor. Cuatro combinaron dos drogas para controlar la enfermedad. Tres pacientes refractarios recibieron gammaglobulina EV con buena respuesta. De 48 evaluados, 39 mostraron mejoría, ocho no tuvieron cambios y uno progresó. En nuestra experiencia, metotrexate y azatioprina son efectivos, con baja toxicidad. Dapsona es útil en casos leves, con efectos adversos frecuentes. La gammaglobulina EV fue efectiva en casos refractarios.Ocular cicatricial pemphigoid (OCP is a blistering autoimmune disease that can produce severe conjunctival damage. Its response to immunosuppressive treatment is poorly known. We describe a group of 76 patients, 62 women and 14 men. Mean age at diagnosis was 67±14 years old, with a delay to diagnosis of 7.5±10 years. Sixty patients continued their follow up in our services for 19±21 months. Nineteen out of 51 had mild disease, 19 moderate, 5 severe and 8 very severe at onset of treatment. The more frequently prescribed drugs were dapsone, in 35 (23 discontinued it because of adverse effects, and methotrexate in 42 patients, nine of them stopped it. Other patients

  20. Clinical features and in vivo confocal microscopy assessment in 12 patients with ocular cicatricial pemphigoid

    Science.gov (United States)

    Long, Qin; Zuo, Ya-Gang; Yang, Xue; Gao, Ting-Ting; Liu, Jie; Li, Ying

    2016-01-01

    AIM To describe the clinical features and microstructural characteristics assessed by in vivo confocal microscopy (IVCM) in patients with ocular cicatricial pemphigoid (OCP). METHODS A descriptive, uncontrolled case series study. Patients diagnosed with OCP were examined by clinical history, slit-lamp biomicroscopy features and IVCM images. The results of direct immunofluorescence (DIF) biopsies and indirect immunofluorescence (IIF) were also recorded. Local and systemic immunosuppressive therapy were administered and adjusted according to response. RESULTS A total of 12 consecutive OCP patients (7 male, 5 female; mean age 60.42±10.39y) were recruited. All patients exhibited bilateral progressive conjunctival scarring and recurrent chronic conjunctivitis was the most frequent clinical pattern. The mean duration of symptoms prior to diagnosis of OCP was 2.95±2.85y (range: 5mo to 10y). The Foster classification varied from stage I to IV and 20 eyes (83%) were within or greater than Foster stage III on presentation. Two of the 12 patients (17%) demonstrated positive DIF; 3 of the 12 (25%) patients reported positive IIF. The mean duration of the follow-up period was 20.17±11.88mo (range: 6 to 48mo). IVCM showed variable degrees of abnormality in the conjuctiva-cornea and conjuctival scarring was detected in all the involved eyes. Corneal stromal cell activation and dendritic cell infiltration presented as ocular surface inflammation, ocular surface keratinization along with the destroyed Vogt palisades was noted in eyes with potential limbal stem cell deficiency. After treatment, remission of ocular surface inflammation was achieved in all the patients, 18 eyes (75%) remained stable, 6 eyes (25%) had recurrent conjunctivitis and cicatrization in 2 eyes (8%) was progressing. CONCLUSION As an autoimmune disease, OCP manifests as variable degrees of clinical and laboratory abnormalities with both local and systemic immunosuppressive treatment playing important roles

  1. Cicatricial ectropion correction in a patient with pyoderma gangrenosum: case report Correção de ectrópio cicatricial em paciente com pioderma gangrenoso: relato de caso

    Directory of Open Access Journals (Sweden)

    Fernando Procianoy

    2009-06-01

    Full Text Available A 19 year old female with pyoderma gangrenosum was referred to the oculoplastic clinic for evaluation of severe cicatricial ectropion of the right lower eyelid. Examination evidenced important scarring of lower eyelid and malar region with secondary ectropion. A full-thickness skin graft associated with a lateral tarsal strip procedure and scar tissue release was performed. The patient's corticosteroid dose was raised for the procedure, and after surgery there was no healing problem or ulcer formation in the eyelid or in the graft donor site. As pyoderma gangrenosum is associated with a pathergy phenomenon in up to 25% of the cases, the onset of new lesions is a relevant concern when performing surgery in these patients. In this case, the surgery was safely performed under corticosteroid immunosuppression.Paciente do sexo feminino de 19 anos com pioderma gangrenoso foi encaminhada ao setor de Plástica Ocular para avaliação de ectrópio cicatricial grave da pálpebra inferior direita. O exame evidenciou cicatrização importante na pálpebra inferior e região malar com um ectrópio secundário. Foi realizado liberação do tecido cicatricial e um enxerto de pele total associado a "tarsal strip". A dose de corticóide da paciente foi aumentada para a realização do procedimento e não houve problemas de cicatrização ou formação de úlceras na pálpebra ou no sítio doador após a cirurgia. Como o pioderma gangrenoso é associado ao fenômeno de patergia em até 25% dos casos, o surgimento de novas lesões é uma preocupação relevante ao indicar cirurgia nestes pacientes. Neste caso, a cirurgia foi realizada com segurança sob imunossupressão com corticóide.

  2. The Treatment experience of Cicatricial eyelid ectropion after severe burns%严重烧伤后瘢痕性睑外翻的治疗体会

    Institute of Scientific and Technical Information of China (English)

    李丽; 牛惠彩; 李卫卫; 王超

    2014-01-01

    Objective:To investigate rational methods to repair different type of cicatricial ectropion .Methods:20 patients with different type and degree of cicatricial ectropion were repaired with the method of simple skin grafting,nasolabial groove skin flap pedicled with inner canthus vessels,posterior auricular refluxing axial skin flap or musculus dormitator skin flap.Results:After 3-6 months follow—up observation all patients got good repaired effects.Necrobiosis occurred in distal skin flap of one patient with posterior auricular refluxing axial skin flap method.Conclusion:Cicatricial ectropion was complicated.Appropriate method should be applied to different cicatricial ectropion to achieve good results.%目的:探讨面部严重烧伤后导致不同程度瘢痕性睑外翻的修复方法。方法:对20例烧伤后不同程度的瘢痕性睑外翻,采用内眦血管蒂鼻唇沟皮瓣、眼轮匝肌皮瓣修复及瘢痕松解植皮修复。结果:皮片局部皮瓣均一期成活,1例返流轴型耳后岛状皮瓣术后皮瓣远端出现表皮坏死,经换药后创面愈合。随访3~10月,眼睑外翻均得到充分矫正,效果良好。结论:瘢痕性睑外翻病情复杂多样,须根据具体情况采用恰当方法,可取得良好效果。

  3. Community-based transconjunctival marginal rotation for cicatricial trachoma in Indians from the Upper Rio Negro basin

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    O.E. Soares

    2004-05-01

    Full Text Available The objective of the present study was to describe, for the first time in Brazil, the use by a non-ophthalmologist of a community-based marginal rotation procedure by a posterior approach in the indigenous population from the Upper Rio Negro basin. Seventy-three upper eyelids of 46 Indians (11 males and 35 females with cicatricial upper eyelid entropion and trichiasis were operated in the Indian communities using a marginal rotational procedure by a posterior approach by a non-ophthalmologist physician who had general surgery experience but only an extremely short period (one week of ophthalmic training. Subjects were reevaluated 6 months after surgery. Results were classified according to the presence and location of residual trichiasis and symptoms were assessed according to a three-level subjective scale (better, worse or no change. Fifty-six eyelids (76.7% were free from trichiasis, whereas residual trichiasis was observed in 17 eyelids (23.3% of 10 subjects. In these cases, trichiasis was either lateral or medial to the central portion of the lid. Of these 10 patients, only 4 reported that the surgery did not improve the irritative symptoms. We conclude that marginal rotation by a posterior approach is an effective and simple procedure with few complications, even when performed by non-specialists. Due to its simplicity the posterior approach is an excellent option for community-based upper eyelid entropion surgery.

  4. Atualização no tratamento das ceratoconjuntivites cicatriciais Update of the treatment of cicatricial keratoconjunctivitis

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    José Alvaro Pereira Gomes

    2000-02-01

    Full Text Available As ceratoconjuntivites cicatriciais (CCC representam um grupo de doenças que induz seis tipos principais de alterações oculares: olho seco; alterações palpebrais; destruição do limbo e células germinativas corneais; destruição da membrana basal; processo inflamatório; alteração na integração neuroanatômica da superfície ocular. Essas alterações acabam causando instabilidade epitelial corneal, vascularização e inflamação crônica. O resultado final é a perda de transparência da córnea e diminuição da acuidade visual. O autor descreve os seis tipos de alterações e faz uma revisão atualizada do tratamento de cada um deles.Cicatricial keratoconjunctivitis is a group of diseases that induces six different types of ocular disorders: dry eye; eyelid blinking disturbances; destruction of limbal stem cells; destruction of basement membrane; inflammation; and neuroanatomic disintegration. These disorders cause corneal epithelial instability, neovascularization and chronic inflammation which result in loss of corneal transparency and decreased visual acuity. The author describes the six types of disorders and reviews the latest therapeutic approaches for each of them.

  5. Clinicopathological analysis of 53 cases of cicatricial alopecia%53例瘢痕性秃发的临床和病理特点分析

    Institute of Scientific and Technical Information of China (English)

    戚世玲; 赵莹; 张小婷; 张斌; 杨建; 章星琪

    2013-01-01

    目的 探讨瘢痕性脱发的临床、组织病理与皮肤镜特点,以及治疗和预后的特征.方法 回顾性分析53例瘢痕性脱发患者的临床资料,分析其组织病理、皮肤镜征象、治疗和预后的特点.结果 瘢痕性脱发以脱发、毛囊开口消失、毛囊皮脂腺单位数目减少或消失为共同特征.基底细胞局灶液化变性、毛囊角栓、毛细血管分支状扩张、免疫荧光阳性提示盘状红斑狼疮;界面皮炎提示毛发扁平苔藓;炎症和弹力纤维轻微破坏提示假性斑秃;毛囊间黏蛋白沉积及毛囊口下陷为黏蛋白性脱发的特点;脓疱可见于脱发性毛囊炎和分割性蜂窝织炎或毛囊炎,前者多伴有簇状发,窦道形成则仅见于后者.治疗对淋巴细胞性患者使用免疫抑制剂,对中性粒细胞性患者使用抗生素和维A酸.结论 组织病理检查对诊断起决定性作用.瘢痕性脱发造成不可逆的毛囊损害,治疗周期长.早期诊断及早期合理用药可控制疾病发展,减少永久性脱发损害.%Objective To investigate the clinical,histopathological and dermoscopic features as well as treatment and prognosis of cicatricial alopecia.Methods Clinical data on 53 patients with cicatricial alopecia were retrospectively collected and studied.Pathological and dermoscopic characteristics,as well as treatment modality and prognosis of cicatricial alopecia were analyzed.Results Cicatricial alopecia was characterized by alopecia,disappearance of follicular ostia,and absence or decrease in the number of polisebaceous gland units.Pathologically,focal liquefactive degeneration of basal cells,follicular keratotic plugs,arborising telangiectasia together with a positive immunofluorescence test were usually suggestive of discoid lupus erythematosus,interface dermatitis suggestive of lichen planopilaris,inflammation and mild disruption of elastic fibers suggestive of classic pseudopelade of Brocq.Mucin deposition between hair

  6. Adiaspiromicose humana: lesões cicatriciais em linfonodos do mediastino Human adiaspiromycosis: cicatricial lesions in mediastinal lymph nodes

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    Mário A.P. Moraes

    2004-03-01

    Full Text Available Em paciente de 60 anos, sexo masculino, com diagnóstico radiográfico de massa tumoral no pulmão direito - depois reconhecida, por meio de biópsia transbrônquica, como de natureza maligna -, não se descobriu qualquer evidência tomográfica de metástases a distância. Resolveu-se então, para fins de estadiamento da neoplasia, obter material de linfonodos mediastinais. O exame microscópico desse material não demonstrou invasão neoplásica, mas revelou a presença de granulomas em avançado estádio de fibrose, contendo raras estruturas redondas, vazias, de parede espessa e, quase sempre, colapsada, que foram reconhecidas como adiaconídios de Emmonsia crescens. Havia ainda, nos cortes histológicos, grande quantidade de pigmento antracótico.Chest roentgenogram of a sixty-year-old male patient, revealed a tumoral mass in the right lung, that was later demonstrated by transbronchial biopsy, to be a bronchogenic adenocarcinoma. There was no tomographic evidence of distant metastasis, however, in order to assess the mediastinal involvement for staging of the tumor, biopsies from the regional lymph nodes were obtained. Microscopic examination of the sample tissues failed to show any metastatic lesion, but, unexpectedly, revealed the presence of cicatricial granulomas in an advanced stage of fibrosis. They contained a few round, empty and collapsed corpuscles, limited by a thick PAS-positive, membrane. These structures were identified as adiaconidia of Emmonsia crescens, the etiological agent of human adiaspiromycosis. In the tissue sections, a large amount of carbon dust (anthracosis was also seen.

  7. Membrana amniótica nas cirurgias reconstrutivas da superfície ocular nas ceratoconjuntivites cicatriciais Amniotic membrane for ocular surface reconstruction in cicatricial keratoconjunctivitis

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    José Alvaro Pereira Gomes

    1999-10-01

    Full Text Available Objetivo: A membrana amniótica tem se consolidado como útil adjuvante no tratamento de afecções da superfície ocular. Sua utilização baseia-se na capacidade de beneficiar o processo de epitelização, além de reduzir os processos inflamatório, angiogênico e cicatricial. O objetivo deste trabalho foi investigar a utilização da membrana amniótica como adjuvante no tratamento das ceratoconjuntivites cicatriciais. Métodos: A membrana amniótica foi captada a partir de parto cesárea e conservada em meio de preservação de córnea e glicerol 1:1 e conservada à -80ºC. Onze olhos de 10 pacientes portadores de ceratoconjuntivite cicatricial grave foram submetidos à cirurgia reconstrutiva da superfície ocular empregando membrana amniótica associada (8 casos ou não (3 casos a transplante de limbo e conjuntiva. Dos 10 pacientes, 3 tinham diagnóstico de síndrome de Stevens-Johnson (SSJ (4 olhos, 6 queimadura ocular por álcali (6 olhos e 1 trauma mecânico (1 olho. Resultados: O tempo médio de seguimento foi de 5,22 meses (variação entre 2 e 13 meses. Um caso de SSJ apresentou infecção pós-operatória e foi excluído da análise dos resultados. Dos outros 10 casos, obtivemos êxito na reconstrução da superfície ocular em 8 casos (80%. Insucesso foi observado em 2 casos de SSJ que apresentavam necrose de córnea no momento da cirurgia (20%. Em relação à acuidade visual, observamos que todos os pacientes apresentaram melhora ou manutenção da acuidade visual. Conclusões: O uso de membrana amniótica constitui uma opção alternativa de grande utilidade na reconstrução da superfície ocular dos casos graves de ceratoconjuntivites cicatriciais que não estejam apresentando necrose estromal. Estudos com maior casuística e tempo de seguimento são necessários para melhor avaliar esse procedimento.Purpose: Amniotic membrane has been consolidated as an useful adjunct in the treatment of ocular surface disorders. Its use is

  8. Shrimp diet and skin healing strength in rats Dieta com camarão e resistência cicatricial da pele, em ratos

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    Elizabeth Lage Borges

    2007-06-01

    Full Text Available OBJECTIVE: Surgical scar tensile strength may be influenced by several factors such as drugs, hormones and diet. The purpose of the present study was to determine the influence of a shrimp-enriched diet on the tensile strength of rat scars. METHODS: Forty male Wistar rats were submitted to a 4 cm dorsal skin incision and the wounds were sutured with 5-0 nylon interrupted suture. The animals were divided into two groups: Group 1 (control received a regular diet, and Group 2 (experimental received a shrimp-enriched diet. The two diets contained the same amounts of proteins, lipids and carbohydrates. The rats in each group were divided into two subgroups according to the time of assessment of the scar tensile strength: subgroup A, studied on the 5th postoperative day, and subgroup B, studied on the 21st postoperative day. RESULTS: The tensile strength of the scar on the 5th postoperative day was lower in the animals that received the shrimp-enriched-diet (303.0, standard error of mean= 34.1 than in the control group (460.1, SEM = 56.7 (pOBJETIVO: A resistência cicatricial da pele pode ser influenciada por diversos fatores como medicamentos, hormônios e dieta. Este trabalho foi delineado para determinar a influência da dieta com camarão na resistência cicatricial na pele. MÉTODOS: Quarenta ratos machos Wistar foram submetidos a incisão (4cm e suturas interrompidas da pele dorsal, com fio de nylon 5-0, e foram divididos em dois grupos: o Grupo 1 (controle recebeu uma dieta convencional e Grupo 2 (experimental, recebeu dieta com adição de com camarão. As duas dietas continham quantidades semelhantes de proteína, lipídeos, e carboidratos. Os ratos de cada grupo foram divididos em dois subgrupos de acordo com os distintos períodos pós-operatórios de avaliação da resistência tecidual: subgrupo A, estudado no 5° dia pós-operatório, e subgrupo B, estudado no 21° dia pós-operatório. RESULTADOS: A resistência cicatricial da pele no 5

  9. Application of relay expansion for large cicatricial alopecia%接力扩张法在大面积瘢痕性秃发修复中的应用

    Institute of Scientific and Technical Information of China (English)

    刘烨; 朱飞; 宁金龙; 汪垠

    2012-01-01

    To investigate the clinical effect of relay expansion for large cicatricial alopecia. A single surgery was divided into two stages: In stage I , several soft tissue expanders were inserted in subgaleal plane, which would gradually spread the normal scalp organization; In stage II , the expanders were removed, and advanced expansion and rotation flaps were used to repair larger cicatricial alopecia. The surgery was relayed to repair the remaining large cicatricial alopecia with satisfactory result.%探讨应用接力扩张法修复大面积瘢痕性秃发的临床效果.手术分期进行:Ⅰ期按设计在头皮帽状腱膜下埋置扩张器,缓慢扩张正常头皮组织;Ⅱ期取出扩张器,推进或旋转扩张皮瓣修复部分瘢痕性秃发区,同时于头皮瓣下接力置放扩张器,待切口愈合良好后注水扩张;扩张过程完成后再次手术修复残余瘢痕秃发区.以此方法重复进行,直至瘢痕完全去除,效果满意.

  10. 高密度毛发移植术在瘢痕性脱发治疗中的应用%Application of high-density hair transplantation in treatment of cicatricial alopecia

    Institute of Scientific and Technical Information of China (English)

    张菊芳; 沈海燕; 韩蕾; 付丽; 郭晓波; 祝飞; 李金晟

    2011-01-01

    Objective To investigate the effect of high-density hair transplantation on the treatment of cicatricial alopecia and its features. Methods The units of transplanted hair follicle were counted according to the area of cicatricial alopecia and required hair density. Scalp strip from the occipital region ( donor site) was harvested, and then it was transplanted into the recipient sites ( cicatricial alopecia) after the taken scalp was made into hair follicle units with anatomic structure reservation by microscopic dissection. From January 2005 to December 2010 , totally 76 patients with cicatricial alopecia underwent the operation metioned above. Results After 6 ~ 18 months follow-up in 76 patients , excellent results ( complete cover) were achieved in 36 patients, good ( basic cover) in 24 patients, so-so (lower-density transplanted hair or part uncovered cicatricial alopecia ) in 16 patients. All cases were satisfied with the results except for 2 patients with epidermoid cysts which were healed with local treatments. Conclusion The high-density hair transplantation is a good method for treating cicatricial alopecia with such advantages as slight invasion, quick recovery , high transplanting density , high survival rate and satisfactory postoperative results. It is worth extending in clinic.%目的 探讨高密度毛发移植术在瘢痕性脱发修复中的疗效及其特点.方法 首先根据脱发区的面积及毛发的移植密度计算出移植毛囊的单位数;然后以患者的枕后部为供区,切取优势的头皮条,采用显微分割的方法将其制成保留正常解剖结构的毛囊单位后植入脱发区.自2005年1月至2010年12月,对76例瘢痕性脱发患者行高密度毛发移植术.结果 术后随访76例患者6~18个月,其中脱发区被完全覆盖者36例,为优;基本覆盖者24例,为良;毛发的密度较低,仍有部分脱发区外露者13例,为可;头皮瘢痕明显外露者3例,为差.移植后的

  11. Padrão dermatoscópico das alopecias cicatriciais causadas por lúpus eritematoso discoide e líquen plano pilar Dermoscopy patterns of cicatricial alopecia resulting from discoid lupus erythematosus and lichen planopilaris

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    Bruna Duque Estrada

    2010-04-01

    Full Text Available FUNDAMENTOS: A dermatoscopia é método importante de diagnóstico de doenças melanocíticas benignas e malignas. Recentemente, o uso desse método tem demonstrado grande ajuda também no diagnóstico e acompanhamento das alopecias. OBJETIVO: Descrever e demonstrar os achados dermatoscópicos de pacientes com quadros clínicos e histopatológicos de alopecia cicatricial. MÉTODOS: Estudo transversal descritivo em que foram selecionados, pelos achados clínicos e histopatológicos do couro cabeludo, 14 pacientes com alopecia cicatricial, sendo quatro casos de líquen plano pilar clássico, cinco casos de alopecia fibrosante frontal e cinco com lúpus eritematoso discoide. Os pacientes foram avaliados com videodermatoscópio e dermatoscópio manual por três examinadores diferentes, de forma independente. Os aumentos variaram de 10 a 70 vezes. RESULTADOS: Foram achados predominantes no lúpus eritematoso discoide placas brancas, capilares arboriformes, tampões ceratósicos e áreas com diminuição dos óstios foliculares; no líquen plano pilar clássico, escamas perifoliculares, pontos brancos e diminuição de óstios foliculares; na alopecia fibrosante frontal, diminuição de óstios foliculares, escama e eritema perifolicular, além de capilares arboriformes. As estruturas azul-acinzentadas, demonstradas neste estudo, não foram descritas na literatura. CONCLUSÕES: O uso da dermatoscopia na avaliação clínica das alopecias ajudou a estabelecer elementos semióticos, melhorou a capacidade de diagnóstico em relação à simples inspeção e revelou novas características das alopecias cicatriciais.BACKGROUND: Dermoscopy is an important tool for the diagnosis of benign and malignant melanocytic diseases. Recently, this method has also been found to be extremely useful in the diagnosis and follow-up of alopecias. OBJECTIVE: The objective of this study was to describe dermoscopic findings in patients with clinical and histopathological

  12. Updates on Clinical Management of Primary Cicatricial Alopecia%原发性瘢痕性脱发的研究进展

    Institute of Scientific and Technical Information of China (English)

    章星琪

    2013-01-01

    原发性瘢痕性脱发是一组以毛囊为中心受到永久性和炎症性破坏为特征的脱发性疾病,病因不明.按病理特点分为淋巴细胞性(如盘状红斑狼疮脱发和毛囊扁平苔藓)、中性粒细胞性(如脱发性毛囊炎和分割性蜂窝织炎/毛囊炎)、混合性(如瘢痕疙瘩性毛囊炎/痤疮)和非特异性4类本病有不可复性,如不能及时而有效的接受治疗,进展到瘢痕晚期会导致永久脱发.治疗可阻止病变发展,但不能彻底根治,故本病易反复发作.本文对原发性瘢痕性脱发的诊断、治疗和发病机制等进展进行综述.%Primary cicatricial alopecia ( PCA ) include a group of disqrders characterized by permanent destruction of the hair follicle and irreversible hair loss caused by inflammatory infiltration, with unknown etiology. The commonly used classification of PCA is based on pathology findings and divided it into lymphocytic such as discoid lupus and lichen planopalaris, neutrophilic such as folliculitis decalvans, mixed such as folliculitis (acne) keloidalis and nonspecific. Because of its irreversibility, once diagnosed, effective management should be installed to prevent scarring stage. However, treatment is only to arrest the progress of the disease, but not to eradicate the disorder, because of the largely unknown cause and pathogenesis. Details of classification, diagnosis, options for management and etiology of PCA are now focus in international hair research field and it will be discussed in this review.

  13. Retrospective analysis of ocular cicatricial pemphigoid%眼瘢痕性类天疱疮病例的回顾性分析

    Institute of Scientific and Technical Information of China (English)

    晏晓明; 陈酉; 李海丽; 荣蓓; 杨松霖

    2010-01-01

    Objective To analyze the clinical characterization of ocular cicatricial pemphigoid (OCP). Methods It was a retrospective series case study. Five consecutive patients referred for the evaluation of possible OCP from January 2005 to October 2008 in Departments of Ophthalmology and Dermatology of Peking University First Hospital History and clinical characterization of 5 cases ( 10 eyes) OCP having been misdiagnosed were analyzed to find the causes of misdiagnosis. Results All of cases were diagnosed as chronic conjunctivitis during the early stages of the diseases, one case was diagnosed as Stevens-Johnson syndrome and one as Sj(o)gren syndrome during the later stage. It was two to five years from the first time to see a doctor to definite diagnosis. All of cases have been prescribed antibiotic eye drops for a long times, one case has been undergone three times trichiasis operation and made the disease progression.Among the five patients with OCP, 3 eyes were diagnosed Stage Ⅱ , 5 eyes Stage Ⅲ, 2 eyes Stage Ⅳ. Three cases were positive of bacterial culture. Only in 1 case, there was slight increase of iron protein as tumor mark. Inflammation was controlled by the end of the study, but cicatrization of 2 cases still progressed.Conclusion Manifestation of OCP can mimic chronic conjunctivitis during the early stages, it is important to pay high attention to OCP, misdiagnosis may be stopped.%目的 探讨眼瘢痕性类天疱疮(OCP)的临床特点.方法 回顾性系列病例研究.回顾2005年1月至2008年10月于北京大学第一医院眼科和皮肤科联合确诊为OCP的系列病例5例(10只眼)患者的病史、眼科常规检查、结膜囊细菌培养及全身免疫学常规检查的结果,分析其误诊原因.结果 确诊前,5例患者在早期均误诊为慢性结膜炎,在这些病例瘢痕较明显时,1例曾被误诊为Stevens-Johnson综合征,1例误诊为干燥综合征,患者从首次就诊至确诊的时间长达2~5年.在确诊

  14. Clinical effect of surgical reconstruction of Ⅱ and Ⅲ degree cicatricial ectropion in 46 patients%46例Ⅱ、Ⅲ度瘢痕性睑外翻手术治疗的临床分析

    Institute of Scientific and Technical Information of China (English)

    李维娟; 雷泽源; 王韶亮; 张一鸣; 樊东力

    2014-01-01

    目的:探讨瘢痕性睑外翻的手术细节的改进及治疗效果。方法回顾我科收治的Ⅱ、Ⅲ度瘢痕性睑外翻患者46例,根据睑外翻的程度和局部情况,选择眼睑部正常皮肤与瘢痕组织交界处设计切口线,尽可能保留和恢复眼轮匝肌结构,松解区域分别超出内外眦处并达眼裂水平,采用全厚皮片游离移植术行睑外翻手术矫正并行睑缘融合,皮片于内外眦韧带处行皮内固定。结果随访6个月至2年,46例眼睑皮片完全存活,眼睑复位良好,无1例眼睑闭合不全。结论适当的选择手术切口线及松解范围,尽可能保留眼轮匝肌的结构完整并对移植皮片在内外眦处进行固定,可以有效预防睑外翻的复发,提升手术效果。%Objective To improve the detail of the surgery for cicatricial ectropion,and the the effect was investigated. Methods Based on 46 patients withⅡ,Ⅲdegree cicatricial ectropion admitted to our department,choose the junction of normal skin and scar tissue as the incision line according to the degree of ectropion and local situation,and to reserve and recover the orbicularis oculi muscle as possible. The released areas exceeded separately the external canthus and reached the level of eye fissure,take advantage of full-thickness skin graft to correct the parallel lines and make fixation to the eyelid ectropion fusion skin graft on external canthal ligament. Results After followed up for 6 months to 2 years,46 cases of eyelid skin grafts survived completely and eyelids were in good reduction,with none case of incomplete eyelid closure. Conclusion Choose the surgical incision and the released areas in a proper way to reserve the structural integrity of orbicu-laris muscle and make skin graft fixation to inner and external canthal skin can prevent effectively the recurrence of ectropion and improve surgical progress.

  15. 延期植皮术联合牵引术在重度关节瘢痕挛缩畸形中的应用%The application of delayed skin grafting combined traction in severe joint cicatricial contracture

    Institute of Scientific and Technical Information of China (English)

    徐子寒; 张振信; 王本峰; 孙要文; 郭亚东; 高文杰; 秦高平

    2014-01-01

    目的 探讨在重度关节瘢痕挛缩畸形治疗中,采用延期植皮术联合牵引术的效果.方法 2000年3月至2013年5月,临床治疗25例.对重度关节瘢痕挛缩畸形患者,一期行瘢痕切除松解术,术中保留关节部位的血管、神经、肌腱等重要组织,创面用脱细胞猪皮生物敷料覆盖、包扎.术后行关节部位持续皮牵引7~14d,待关节恢复到伸直位,即行二期自体皮移植术.结果 25例患者二期植皮术后2~3周创面一期愈合,皮片完全成活、色泽及弹性良好,关节屈伸基本正常.经3个月至11年的随访,除1例肩关节功能锻炼不积极,效果欠佳,其余均无瘢痕增生、挛缩,关节功能恢复满意.结论 延期植皮术联合牵引术可有效提高皮片成活率、减轻瘢痕形成,关节功能得到良好恢复,提高了患者生活质量.%Objective To investigate the effect of delayed skin grafting combined traction in severe joint cicatricial contracture.Methods At the first stage,the joint cicatricial contracture was released completely with protection of vessels,nerves and tendons.The wound was covered with allogenetic skin or biomaterials.After skin traction for 7-14 days,the joint could reach the extension position.Then the skin graft was performed on the wound.25 cases were treated from Mar.2000 to May.2013.Results Primary healing was achieved at the second stage in all the cases.The skin graft had a satisfactory color and elasticity.Joint function was normal.All the patients were followed up for 3 months to 11 years with no hypertrophic scar and contraction relapse,except for one case who didn' t have enough active exercise on shoulder joint.Conclusion Delayed skin grafting combined traction can effectively increase the skin graft survival rate and improve the joint function recovery.

  16. Morfometria de fibroblastos e fibrócitos durante o processo cicatricial na pele de coelhos da raça Nova Zelândia Branco tratados com calêndula Morphometry of fibroblasts and fibrocytes during wound healing in the skin of rabbits of the New Zeland White breed treated with marigold

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    Leonardo de Oliveira Pagnano

    2008-09-01

    Full Text Available O objetivo deste estudo foi avaliar a capacidade cicatrizante da calêndula (Calendula officinalis L. sobre feridas cutâneas experimentais, em 15 coelhos, distribuídos em três grupos denominados: excipiente, calêndula e controle. Cada animal foi submetido à uma incisão cirúrgica de 6cm de comprimento, lateral à coluna vertebral e suturada no padrão U. Os produtos avaliados foram colocados sobre as incisões durante sete dias na quantidade de 0,1ml (loção cremosa não-iônica - grupo excipiente; tintura de calêndula a 5% - grupo calêndula e nos animais do grupo controle não se utilizou nenhum produto. A biópsia de pele foi realizada no 1°, 3°, 5° e 7° dia após a incisão cirúrgica para avaliação morfométrica do processo cicatricial, analisando-se o número de fibroblastos e fibrócitos. A morfometria foi realizada por meio de microscópio óptico adaptado a um sistema computadorizado de análise de imagens. De acordo com os resultados, a calêndula propiciou obtenção dos maiores valores médios das células envolvidas no processo cicatricial, os fibroblastos, deduzindo que a mesma, inferiu uma resposta mais satisfatória na cicatrização em relação aos demais tratamentos.The aim of this study was to evaluate the scarring capability of marigold (Calendula officinalis L. on experimental skin wounds in 15 rabbits, distributed in three groups: excipient, marigold and control. Each animal was subjected to a surgical incision measuring 6cm in length, laterally to the spinal column and sutured in U-shape. Products evaluated were placed on the incisions for 7 days, at a rate of 0.1ml (nonionic creamy lotion - excipient group; 5% marigold extract and no treatment was provided to control animals. Skin biopsy was performed on 1, 3, 5, and 7 days after wounding, for morphometric and cicatricial process evaluations. The morphometry was performed with an optical microscope adapted to a computadorized picture analysis system. The

  17. Clinical study of repairing donor site of thickness from cicatricial skin with auto-scalp grafting%自体头皮移植修复瘢痕皮肤中厚供皮区创面的效果观察

    Institute of Scientific and Technical Information of China (English)

    申传安; 柴家科; 张琳; 李东杰; 庹晓晔; 蔡建华; 王淑君; 朱华; 蔡金东

    2013-01-01

    Objective To study the effects of using auto-scalp for repairing donor site of thickness from cicatricial skin with auto-scalp grafting.Methods A total of 13 cases with donor site of thickness from cicatricial skin from January 2011 to December 2011 were analyzed.Wounds of donor site from cicatricial skin were grafted with auto-scalp and scalp were fixation was applied with negative pressure.The survival rate of auto-scalp graft was observed at Day 7 post-operation.At Month 12,hyperplastic scars at these donor sites of cicatricial skin were assessed through Vancouver Scar Assessment Table,scar itch assessment and scar proliferation rate.Wounds in the other thirteen cases with donor site of thickness from cicatricial skin from January 2010 to December 2010 were covered with vaseline gauze as control.Results No significant difference existed in the gender and age of the two groups patients (P > 0.05).The auto-scalp graft all survived.And the average healing time of donor-site wound in cicatricial skin in grafting group (7 days) was significantly decreased than that of control group (a mean of 20 days) (P < 0.01).After followed up for twelve months,the scar formation assessment value (1.5 ± 0.5),scar itch assessment (1.2 ± 0.4) and scar proliferation rate (14.6% ± 7.6%) in grafting group were significantly less than those of control group (6.7 ±1.1,2.0 ±0.7,55.8% ± 12.2%,all P<0.01).Conclusion Auto-scalp grafting may greatly shorten the healing procedure and ameliorate the quality of donor-site of thickness from cicatricial skin.%目的 观察自体头皮移植修复瘢痕皮肤中厚供皮区创面的临床效果.方法 对2011年1至12月解放军总医院第一附属医院烧伤整形科收治的13例以瘢痕皮肤为中厚供皮区的大面积烧伤后整形患者(植皮组)的临床资料进行回顾性分析,瘢痕供皮区创面均采用自体中厚头皮皮片移植,并使用负压治疗技术固定皮片,手术后第7天拆除敷料,观

  18. Avaliação macroscópica, microscópica e histomorfométrica do tecido cicatricial pós-cirúrgico de eqüinos submetidos a duas técnicas de neurectomia digital Macroscopic, microscopic, and histomorphometric evaluation of post-operative scar tissue in horses submitted to two techniques for digital neurectomy

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    A. Escobar

    2008-08-01

    Full Text Available Avaliou-se macro e microscopicamente o tecido cicatricial pós-operatório de eqüinos submetidos a duas técnicas de neurectomia digital: guilhotina (TG e stripping (TS. Decorridos 14 meses das cirurgias, foram colhidas 32 amostras de tecido cicatricial em quatro éguas, que tiveram os membros submetidos a ambas as técnicas. À macroscopia, verificaram-se as dimensões da cicatriz do coto proximal e a distância entre os cotos proximal e distal. À microscopia, foi quantificada a proporção de tecido nervoso regenerado por meio de histomorfometria. Não houve diferença nas dimensões do tecido cicatricial, contudo a distância entre cotos foi 5,6 vezes maior na TS (PThe post-operative healed tissues in horses submitted to two digital neurectomy techniques, the guilhotine (GT and the stripping (ST, were evaluated by macroscopy and microscopy. Fourteen months after surgery, 32 samples of scar tissue were collected from four mares that had the members experimentally submitted to both surgical techniques. By macroscopy, the dimensions of the scar tissue of the proximal stump and the distance between nerve stumps were taken. By microscopy, the proportion of nervous tissues in the scar tissue was quantified by histomorphometry. There were no differences between the scar tissue dimensions, but the distance between stumps was 5.6-fold greater in ST subjects. Histologically, connective tissue, macrophages, and thin nervous fibers were observed in scar tissue present in animals of both groups. Nodular structures composed by nervous fascicules were visualized in 56.2% (9/16 of the samples collected from the ST group. The mean percentage of the nervous tissue in scar tissue was 0.31% in GT samples and 2.6% in ST samples (P<0.001. After ST, a longer time to the return of the sensibility may occur due to the greater distance between stumps. However, greater proportion of nervous tissue in the scar tissue suggests that the use of this technique favors

  19. 颈肩峰区跨区供血轴型扩张皮瓣修复颈部瘢痕挛缩%Expanded cervico-acromial skin flap of crossing supply axial pattern for the repair of cervical cicatricial contracture

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    胡春梅; 李养群; 唐勇; 杨喆; 赵穆欣; 陈文; 刘媛媛; 许砾思

    2013-01-01

    Objective To investigate the blood supply of an expanded skin flap from cervico-acromial region and its application in the repair of cervical cicatricial contracture.Methods The expanded skin flap pedicled was prepared with arteries of lateral neck,blood supply crossing and abundant anastomotic branchea of the neck-should blood vessels,the frontal bound of which is clavicle,the underneath bound of which is spine of scapula,and the lateral bound of which is acromion,to repair the large soft tissue defects on neck.Results All the 19 flaps of 15 patients were survived.The maximum size was 23 cm × 16 cm.Postoperative follow-up showed that the cervico-mandibular function and the external appearance of the flaps were satisfactory.And the scar in donor sites seemed to be neglectable.Conclusions The blood supply of the cervico-acromial flap is abundant,the subcutaneous fat and skin is quite thin after expended.We can harvest a large expanded skin flap.Reparation of cervical cicatricial contracture with expanded cervico-acromial flap pedicled with arteries of lateral neck could be recommended.%目的 探讨颈肩峰区跨区供血轴型扩张皮瓣的解剖学特征及应用于修复颈部瘢痕挛缩的临床效果.方法 应用颈横动脉分支和胸肩峰动脉吻合支跨区供血,形成前界为锁骨、后界为肩胛岗、外界为肩峰的颈肩峰区的扩张皮瓣,以颈侧为蒂转移修复较大面积的颈部软组织缺损.结果 15例患者的19个颈肩峰扩张皮瓣(面积最大为23 cm× 16 cm)全部成活,颈部畸形矫正良好.结论 颈肩峰区跨区供血的吻合支丰富,于深筋膜浅层进行扩张后皮下脂肪层及皮肤较薄,可以形成较大面积的扩张皮瓣,以颈横动脉颈段皮支为轴型血管,转移修复颈部较严重的瘢痕挛缩畸形,是一个良好的手术方法.

  20. Effect of nitrous oxide inhalant combined with misoprostol on induced abortion of cicatricial uterus%氧化亚氮联合米索前列醇用于哺乳期瘢痕子宫人工流产术的临床观察

    Institute of Scientific and Technical Information of China (English)

    葛彦欣; 张小丽; 林雪

    2011-01-01

    目的 探讨氧化亚氮与米索前列醇并用于哺乳期瘢痕子宫人工流产术的临床效果.方法 将180例哺乳期瘢痕子宫早孕妇女采取随机数字表法分为氧化亚氮组65例、联合组60例,将要求直接施以负压吸引术者55例作为对照组.观察3组术中镇痛效果、宫颈松弛程度、手术时间、出血量、手术并发症的发生率.结果 与对照组比较,氧化亚氮组及联合组镇痛效果明显,联合组宫颈松弛度更佳,且手术时间最短,手术并发症的发生率最低[宫颈松弛度:86.7%比35.4%、18.1%;手术时间:(2.8±2.0)min比(3.6±2.3)min、(4.9±2.2)min;出血量:(13.4±2.8)ml比(17.1±3.1)ml、(19.0±2.8)ml;P<0.05].结论 氧化亚氮镇痛、米索前列醇扩张宫颈,两者联合既能明显减痛,又能降低哺乳期癜痕子宫人工流产手术的操作难度,减少并发症的发生.%Objective To study the effect of nitrous oxide inhalant combined with misoprostol preoperatively on induced abortion of cicatricial uterus. Methods One hundred and eighty pregnant women who were desirous of termination of pregnancy were randomly assigned to receive nitrous oxide in combination with miso-prostol preoperatively( combination group) , nitrous oxide( nitrous oxid group) or none( control group). The main outcomes were analgesic effect, cervical dilatation, the duration of the procedure, intraoperative blood loss, incidences of induced abortion syndrome and other complications. Results The analgesia efficacy in combination group and nitrous oxid group showed significant differences from control group. Compared with nitrous oxid group, combination group showed further cervical dilatation, less duration of the procedure and incidences of complication (P <0. 05). Conclusions Nitrous oxide inhalant in combination with misoprostol preoperatively has proved analgesia efficacy for induced abortion of cicatricial uterus, which decreases the difficulty of operation and the risk of

  1. Retinoblastoma; Le retinoblastome

    Energy Technology Data Exchange (ETDEWEB)

    Desjardins, L.; Doz, F.; Schlienger, P.; Validire, P.; Quintana, E.; Zucker, J.M. [Institut Curie, 75 - Paris (France)

    1996-05-01

    Early symptoms of retinoblastoma (leukocoria, strabismus) and the various steps of the diagnosis and differential diagnosis are reviewed. Retrolental fibroplasia, larva migrans, Coats disease, and above all uveitis are the main differential diagnoses. Pathologic features that allow the diagnosis and have a bearing on the prognosis are described. Genetic factors involved in the genesis of retinoblastoma are reviewed, including recent data provides by molecular biology studies of chromosome 13. Currently available treatments include enucleation, external beam radiation, iodine-125 disks, xenon photo-coagulation, cryo-application, chemotherapy, and carbo-platinum combined with diode laser hyperthermia. The indications of each of these methods in intra- and extra-ocular retinoblastomas are discussed, as well as results and complications. Emphasis is put on the high risk of a second cancer. 47 refs., 4 figs.

  2. Retinoblastoma

    International Nuclear Information System (INIS)

    Early symptoms of retinoblastoma (leukocoria, strabismus) and the various steps of the diagnosis and differential diagnosis are reviewed. Retrolental fibroplasia, larva migrans, Coats disease, and above all uveitis are the main differential diagnoses. Pathologic features that allow the diagnosis and have a bearing on the prognosis are described. Genetic factors involved in the genesis of retinoblastoma are reviewed, including recent data provides by molecular biology studies of chromosome 13. Currently available treatments include enucleation, external beam radiation, iodine-125 disks, xenon photo-coagulation, cryo-application, chemotherapy, and carbo-platinum combined with diode laser hyperthermia. The indications of each of these methods in intra- and extra-ocular retinoblastomas are discussed, as well as results and complications. Emphasis is put on the high risk of a second cancer. 47 refs., 4 figs

  3. Cicatrici: El secreto de sus ojos di Sacheri e Campanella

    Directory of Open Access Journals (Sweden)

    Sandro Volpe

    2012-12-01

    Full Text Available In 2005 the Argentinian writer Eduardo Sacheri published The Question in Their Eyes (La pregunta de sus ojos.  The novel narrates on a double level, both fictional and temporal, the decision of a retired prosecutor to come to terms with a case of rape and murder which had taken place years earlier: his life had been shattered by the consequences of that tragedy, and writing about it would be a way to start living again.  The director Juan José Campanella - widely famous for having directed episodes of the television series Law & Order, but especially as the director of successful films such as El hijo de la novia - decided to adapt the novel and involved Sacheri in the project: the close collaboration between writer and director produced a bold screenplay that adds to the noir thriller a more romantic dimension.  Disproving the commonplace of the writer jealous of his work, they wrote together a new version which retains certain elements of the original text, but also introduces a number of relevant changes to the structure, characters and ending of the novel.  The Secret in Their Eyes  (El secreto de sus ojos, shot in 2008, was released the following year and in 2010 won the Academy Award for best foreign language film.

  4. Nonviable Staphylococcus aureus and its peptidoglycan stimulate macrophage recruitment, angiogenesis, fibroplasia, and collagen accumulation in wounded rats.

    Science.gov (United States)

    Kilcullen, J K; Ly, Q P; Chang, T H; Levenson, S M; Steinberg, J J

    1998-01-01

    We have previously shown that local application at the time of operation of Staphylococcus aureus, nonviable S. aureus, its cell wall, or S. aureus peptidoglycan accelerates wound healing. We hypothesized that this effect is due to both direct and indirect mechanisms, among which is an increase in the inflammatory response to wounding, resulting in an increase in macrophages, angiogenesis, and fibroblasts. Twenty-seven Sprague-Dawley male rats were anesthetized, and two 7-cm paravertebral skin incisions were made. Four polyvinyl alcohol sponges, two on each side, containing either 100 microliter of isotonic saline or 0.5 mg of nonviable S. aureus or S. aureus peptidoglycan in 100-microliter saline were implanted subcutaneously. Nonviable S. aureus or S. aureus peptidoglycan (860 microgram/cm incision) in 200-microliter saline were inoculated into the incisions at closure. The rats ate a commercial rat chow and drank tap water ad libitum throughout. After days 3 and 7 postwounding, rats were euthanized, and tissues were examined for immunohistochemical features of reparative tissue using ED-1, Factor VIII, and vimentin antibodies, markers for monocyte/macrophages, endothelial cells, and mesenchymal cells (including fibroblasts), respectively. Incisions treated with nonviable S. aureus or S. aureus peptidoglycan showed more macrophages along and deep in the wound tract 7 days postoperatively. Nonviable S. aureus or S. aureus peptidoglycan-treated sponges were surrounded and penetrated by much larger capsules of reparative tissue than saline-treated sponges at both 3 and 7 days. Neutrophil influx was much greater in nonviable S. aureus or S. aureus peptidoglycan-treated sponges, especially in central regions, and there were many more ED-1-stained macrophages in distinct geographic locations, specifically, the more peripheral-cortical areas. Some clustering of macrophages occurred around areas of invasion by reparative tissue into the surrounding subcutaneous fat and within the interstices of the sponges at the interface between reparative tissue and acute inflammatory cells. In contrast, saline-treated sponge reparative tissue had significantly fewer macrophages, much thinner and flimsy reparative tissue, with proportionately fewer macrophages clustering centrally. There were many more mesenchymal cells (notably fibroblasts) and new blood vessels and much more reparative collagen in the nonviable S. aureus or S. aureus peptidoglycan-treated sponges. We conclude that local application of nonviable S. aureus or S. aureus peptidoglycan at wounding induces an increased number and alteration in location of macrophages, increased influx (or proliferation) of mesenchymal cells (notably fibroblasts), and increased angiogenesis and reparative collagen accumulation, as well as increasing the overall acute inflammatory response to wounding. PMID:9776858

  5. Retinopathy of prematurity: Past, present and future

    Science.gov (United States)

    Shah, Parag K; Prabhu, Vishma; Karandikar, Smita S; Ranjan, Ratnesh; Narendran, Venkatapathy; Kalpana, Narendran

    2016-01-01

    Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the retina occurring principally in new born preterm infants. It is an avoidable cause of childhood blindness. With the increase in the survival of preterm babies, ROP has become the leading cause of preventable childhood blindness throughout the world. A simple screening test done within a few weeks after birth by an ophthalmologist can avoid this preventable blindness. Although screening guidelines and protocols are strictly followed in the developed nations, it lacks in developing economies like India and China, which have the highest number of preterm deliveries in the world. The burden of this blindness in these countries is set to increase tremendously in the future, if corrective steps are not taken immediately. ROP first emerged in 1940s and 1950s, when it was called retrolental fibroplasia. Several epidemics of this disease were and are still occurring in different regions of the world and since then a lot of research has been done on this disease. However, till date very few comprehensive review articles covering all the aspects of ROP are published. This review highlights the past, present and future strategies in managing this disease. It would help the pediatricians to update their current knowledge on ROP. PMID:26862500

  6. [Transurethral prostate resection prior to kidney transplantation leading to urethral cicatricial tissue].

    Science.gov (United States)

    Schou-Jensen, Katrine; Mohammad, Wael

    2015-01-26

    In Denmark, kidney transplantations in patients above 50 years have increased during the last decade. Consequently, the number of patients with lower urinary tract symptoms due to prostate hypertrophy increases accordingly. We describe two patients, who both had a resection of the prostate while having anuria and waiting for a kidney transplantation from a deceased donor. In both cases it was impossible to place a urethral catheter during the following transplantation due to total urethral occlusion, so a suprapubic catheter was inserted until the scar tissue was dilated or resected by a later transurethral intervention. PMID:25612989

  7. Pharmacological consequences of oxidative stress in ocular tissues

    Energy Technology Data Exchange (ETDEWEB)

    Ohia, Sunny E. [Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, 141 Science and Research Building 2, University of Houston, Houston, TX 77204 (United States)]. E-mail: seohia@uh.edu; Opere, Catherine A. [Department of Pharmacy Sciences, School of Pharmacy and Health Professions, Creighton University Medical Center, Omaha, NE 68178 (United States); LeDay, Angela M. [Professional and Scientific Relations, Procter and Gamble Pharmaceuticals Inc., Mason, OH 45040 (United States)

    2005-11-11

    The eye is a unique organ because of its constant exposure to radiation, atmospheric oxygen, environmental chemicals and physical abrasion. That oxidative stress mechanisms in ocular tissues have been hypothesized to play a role in diseases such as glaucoma, cataract, uveitis, retrolental fibroplasias, age-related macular degeneration and various forms of retinopathy provides an opportunity for new approaches to their prevention and treatment, In the anterior uvea, both H{sub 2}O{sub 2} and synthetic peroxides exert pharmacological/toxicological actions tissues of the anterior uvea especially on the sympathetic nerves and smooth muscles of the iris-ciliary bodies of several mammalian species. Effects produced by peroxides require the presence of trace amounts of extracellular calcium and the functional integrity of mitochondrial calcium stores. Arachidonic acid metabolites appear to be involved in both the excitatory action of peroxides on sympathetic neurotransmission and their inhibitory effect on contractility of the iris smooth muscle to muscarinic receptor activation. In addition to the peroxides, isoprostanes (products of free radical catalyzed peroxidation of arachidonic acid independent of the cyclo-oxygenase enzyme) can also alter sympathetic neurotransmission in anterior uveal tissues. In the retina, both H{sub 2}O{sub 2} and synthetic peroxides produced an inhibitory action on potassium depolarization induced release of [{sup 3}H] D-aspartate, in vitro and on the endogenous glutamate and glycine concentrations in vivo. Effects caused by peroxides in the retina are mediated, at least in part, by second messengers such as nitric oxide, prostaglandins and isoprostanes. The ability of H{sub 2}O{sub 2} to alter the integrity of neurotransmitter pools from sympathetic nerves in the anterior uvea and glutaminergic nerves in the retina could underlie its role in the etiology of glaucoma.

  8. Post-septal upper eyelid loading for treatment of exposure keratopathy secondary to non-cicatricial lagophthalmos.

    Science.gov (United States)

    Wagh, Vijay Kumar; Lim, Wei S; Cascone, Nikhil C; Morley, A M S

    2016-10-01

    Exposure keratopathy may result in ocular surface dryness, pain, corneal ulceration and loss of vision. Upper eyelid loading is an effective surgical treatment for paralytic lagophthalmos but has been criticised for complications of implant exposure and poor cosmesis. We therefore reviewed the safety and efficacy of our technique of upper eyelid post-septal loading for exposure keratopathy in this context. A retrospective case notes analysis was undertaken of 38 patients who had upper eyelid loading, all with post-septal weight placement, for correction of lagophthalmos. Patient demographics, indications for surgery, outcomes and complications were analysed. The mean age of all patients was 59.6 years. Exposure keratopathy was secondary to facial nerve paralysis in all but two patients, with tumor excision being the commonest underlying aetiology (63.8%). The mean implant weight used was 1.4 grams. Pre-operatively, all 38 patients had ocular discomfort despite maximal use of lubricating eye drops but post-operatively, 29 patients (76.3%) were comfortable without any such drops. Mean lagophthalmos on blink and gentle closure improved from 7.42mm and 5.47mm pre-operatively to 2.18mm and 1.18mm post-operatively (p < 0.001). Similarly, before surgery all patients had some corneal staining but after surgery 37 patients (97.4%) had none. The gold weight was removed in four patients (10.5%), due to chronic inflammation in three and due to mild astigmatism in one. No patient had exposure of the weight and one patient had a ptosis repair 6 months after surgery. Upper eyelid loading was effective in reducing both signs and symptoms of exposure keratopathy related to lagophthalmos in our series. Patients were very satisfied with the surgical outcome and complications related to exposure and cosmesis were very rare. PMID:27541938

  9. Radio-induced superficial fibrosis: investigation of the activation mechanisms of the myo-fibroblast and characterization of the cicatricial epidermis

    International Nuclear Information System (INIS)

    Whereas radio-induced cutaneous fibrosis is one of the frequent after-effects of accidental and therapeutic irradiations, this research thesis addresses the mechanisms which govern the activation of the myo-fibroblast. After some results obtained on cells from a radio-induced fibrosis on swine cells, the author proposes a signalling alteration as a mechanism. In a model a reconstructed skin, the author shows that myo-fibroblasts are a direct target of Superoxide Dismutase (SOD), and respond to this anti-fibrosis agent by a phenotype reversion. She reports the molecular characterization of epidermis of fibro-necrosis human lesions induced by an accidental or therapeutic irradiation. This leads to a better understanding of the role of the myo-fibroblast during the development and regression of fibrosis. Besides, the author shows that an alteration of the epidermis adjacent to dermis is developing in parallel with the fibrosis process. This suggests an active contribution of keratinocytes during the development of this radio-induced after-effect

  10. Processo cicatricial de sutura em ceco com os fios polipropilene, poliglecaprone 25 e glicomer 60 em ratos Healing process with polipropilene, poliglecaprone 25 and glicomer 60 in cecorraphy in rats

    Directory of Open Access Journals (Sweden)

    Luiz Masakatso Nomura

    2009-06-01

    Full Text Available RACIONAL: A despeito de grandes avanços na elucidação dos fatores locais e gerais que interferem na cicatrização, o estado atual ainda não permite dispensar o uso do fio de sutura em intervenções cirúrgicas e a busca pelo fio ideal ainda continua. OBJETIVO: Avaliar suturas em ceco de ratos realizadas com fio monofilamentar absorvível de glicomer 60 (Monosyn®, em relação aos fios polipropilene (Prolene® e poliglecaprone 25 (Monocryl®. MÉTODO: Foram utilizados 72 ratos Wistar, divididos em três grupos de 24 denominados grupo polipropilene, poliglecaprone e glicomer. Os animais de cada grupo foram distribuídos em três subgrupos de oito e avaliados no 3º, 7º e 14º dias de pós-operatório. Os parâmetros estudados foram: teste de resistência à insuflação de ar atmosférico; aspectos macroscópicos; as características histológicas e taxa de hidroxiprolina tecidual. RESULTADOS: O teste de resistência à insuflação de ar atmosférico apresentou baixos valores no 3º dia, com elevação no 7º, mantendo-se nos mesmos níveis no 14º dia, sendo semelhantes em todos os fios estudados. Na análise estatística, não se observou diferença significativa entre os grupos no 3º, 7º e 14º dias de pós-operatório, porém houve aumento significativo da pressão auferida, comparando-se os dias 3 e 7, em todos os grupos. Na análise histológica, avaliada quanto aos aspectos de reação inflamatória, proliferação fibroblástica, colagenização, coaptação das bordas e reepitelização, houve no 7º dia significativamente mais animais do grupo polipropilene com colagenização moderada em relação aos grupos poliglecaprone e glicomer. Os demais resultados não diferiram entre os fios estudados. Na determinação da taxa de hidroxiprolina tecidual, obteve-se a menor taxa nos subgrupos de 3º dia de pós-operatório, de todos os três grupos estudados, observando-se assim paralelismo com o ganho de resistência tênsil à insuflação de ar. CONCLUSÃO: O fio de Monosyn® equiparou-se, nos parâmetros estudados, aos fios de Prolene® e Monocryl® na realização de sutura em ceco de ratos.BACKGROUND: Surgeons are still looking for the ideal suture material, although the progress during the last decades. AIM: To compare cecorrhaphy in rats with three different sutures: polypropylene (Prolene®, polyglecaprone 25 (Monocryl® and glycomer 60 (Monosyn®. METHOD: Seventy-two Wistar rats were divided into three groups of 24 each (polypropylene, polyglecaprone and glycomer groups. Within each group, the animals were assigned to three subgroups and assessed on the 3rd, 7th and 14th postoperative day. The parameters studied were the bursting strength, macroscopic mucosal healing, histology and tissue hydroxyproline rate. RESULTS: The bursting strength had its lower values on the 3rd postoperative day, with significant higher values on the 7th and 14th; there was no difference among groups. In the overall, the histological analysis of the inflammatory reaction, fibroblast proliferation, collagen formation, border attachment and re-epithelization showed the same pattern among the three groups and sub-groups; only on day 7, there was seen a significant higher collagen formation in polypropylene group than polyglecaprone and glycomer groups. The tissue hydroxyproline rate was significant lower in the sub-groups of the 3rd postoperative day, in all of the three studies groups, with increase on days 7 and 14. There was a parallel gain in bursting strength and neo-collagen formation. CONCLUSION: There was no difference among glycomer 60, polypropylene and polyglecaprone sutures in performing cecorrhaphy in rats between days 3 and 14, according to the evaluated parameters.

  11. Esophageal Reconstruction of Jejunum in Patients with Cicatricial Esophageal Stenosis or Atresia%疤痕性食管闭锁或狭窄空肠移植食管重建

    Institute of Scientific and Technical Information of China (English)

    黄金林; 沈小英; 王茂娟

    2000-01-01

    介绍了19例食管疤痕性闭锁或狭窄病例,应用显微外科技术进行了游离或带血管蒂的空肠段移植重建食管术.重点介绍了空肠移植的手术方法和循环重建的问题.结果表明这一手术方法对于疤痕性食管闭锁或狭窄的治疗是一种积极有效的方法.

  12. Trichoscopy update 2011

    OpenAIRE

    Rudnicka, Lidia; Olszewska, Małgorzata; Rakowska, Adriana; Slowinska, Monika

    2011-01-01

    Trichoscopy performed with a handheld dermoscope or a videodermoscope became an indispensable tool in differential diagnosis of hair and scalp diseases. Current research is focusing on trichoscopy of: 1) non-cicatricial alopecia, 2) cicatricial alopecia, 3) hair shaft disorders, and 4) inflammatory scalp diseases. This review summarizes current knowledge in these four fields of research. In all non-cicatricial alopecias presence of empty follicular openings is a common trichoscopy finding. In...

  13. Graham Little Piccardi Lasseur Syndrome: A Rare Case Report with Concomitant Hypertrophic Lichen Planus

    OpenAIRE

    Brar, BK; Khanna, Era; Bharat B Mahajan

    2013-01-01

    Graham Little Piccardi Lasseur Syndrome (GLPLS) is a rare variant of lichen planopilaris comprising of a triad of multifocal and patchy cicatricial alopecia of scalp, non-cicatricial alopecia of axillae and pubic region and keratotic follicular papules over a body. Its exact etiology is not known until date, but primarily involves an immune mediated inflammatory reaction against the bulge region of hair follicles resulting in cicatricial alopecia. We report an extensive and diffuse presentati...

  14. Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis

    Science.gov (United States)

    2016-10-03

    Chemical Injuries; Unspecified Complication of Corneal Transplant; Autoimmune Diseases; Ocular Cicatricial Pemphigoid; Stevens Johnson Syndrome; Lupus Erythematosus, Systemic; Rheumatoid Arthritis; Other Autoimmune Diseases

  15. Análise histológica da cicatrização da anastomose colônica, em ratos, sob ação de enema de Aroeira-do-sertão (Myracrodruon urundeuva fr. all. a 10% Histologic analysis of colonic anastomotic healing, in rats, under the action of 10% Aroeira-do-sertão (Myracrodruon urundeuva fr. all. enema

    Directory of Open Access Journals (Sweden)

    Annya Costa Araújo de Macedo Goes

    2005-04-01

    Full Text Available OBJETIVO: Avaliar, do ponto de vista histológico, a ação do extrato aquoso da aroeira-do-sertão na cicatrização da anastomose colônica, em ratos Wistar. MÉTODOS: Foram utilizados 48 ratos da linhagem Wistar, machos, com peso médio de 320g, distribuídos em dois grupos, com 24 animais, cada. Todos os animais foram submetidos à secção transversa completa do cólon descendente, seguida de anastomose colônica. Os ratos do grupo A receberam diariamente no pós-operatório enemas de veículo à base de carboximetilcelulose (CMC. Os animais do grupo B receberam no pós-operatório enemas de extrato aquoso de aroeira-do-sertão a 10% em veículo à base de CMC, até a data da eutanásia. Nas datas 3, 7, 14 e 21 do experimento, seis ratos de cada grupo foram submetidos à remoção de segmento colônico, incluindo a anastomose, destinado à apreciação histológica e análise qualitativa da resposta celular inflamatória e cicatricial. RESULTADOS: A análise morfológica revela diferença significante entre os grupos, no dia 7 (ñ PURPOSE: Evaluate, from a histologic view point, the action of the aqueous extract of aroeira-do-sertão on the healing of colonic anastomosis, in Wistar rats. METHODS: There were used 48 Wistar rats, males, with average weight of 320g, distributed in two groups, with 24 animals, each. All animals were subjected to a complete transverse section of the descending colon, followed by colonic anastomosis. The rats on group A received daily post-operative enemas of carboxymethylcellulose (CMC based vehicle. The animals on group B received post-operative enemas of 10% aqueous extract of aroeira-do-sertão in CMC based vehicle, until the date of euthanasia. On days 3, 7, 14 and 21 of the experiment, six rats in each group were subjected to removal of a colonic segment, including the anastomosis, destined to histological evaluation and qualitative analysis of inflammatory and healing cell response. RESULTS: The

  16. Alopecia and dermatopathy of the lower back following pelvic fractures in three cats.

    Science.gov (United States)

    Declercq, Jan

    2004-02-01

    An alopecia and dermatopathy following pelvic fractures associated with vehicular trauma is reported in three cats. The animals presented 3-4 weeks post injury with acute hair loss, glistening appearance of the skin and erosions involving the lower back. Histological examination revealed atrophy of the hair follicles and adnexal structures and follicular telogenization, dermal fibroplasia and mild lymphocytic infiltrate, fibroplasia and inflammation in the panniculus. Vascular damage secondary to the external trauma to blood vessels supplying the skin over the lumbar region and subsequent ischaemia may represent the pathomechanism of this type of alopecia. Focal permanent hair loss can be expected.

  17. Morfometria de fibroblastos e fibrócitos durante o processo cicatricial na pele de coelhos da raça Nova Zelândia Branco tratados com calêndula Morphometry of fibroblasts and fibrocytes during wound healing in the skin of rabbits of the New Zeland White breed treated with marigold

    OpenAIRE

    Leonardo de Oliveira Pagnano; Silvana Martinez Baraldi-Artoni; Maria Rita Pacheco; Edanir dos Santos; Daniela Oliveira; Jeffrey Frederico Lui

    2008-01-01

    O objetivo deste estudo foi avaliar a capacidade cicatrizante da calêndula (Calendula officinalis L.) sobre feridas cutâneas experimentais, em 15 coelhos, distribuídos em três grupos denominados: excipiente, calêndula e controle. Cada animal foi submetido à uma incisão cirúrgica de 6cm de comprimento, lateral à coluna vertebral e suturada no padrão U. Os produtos avaliados foram colocados sobre as incisões durante sete dias na quantidade de 0,1ml (loção cremosa não-iônica - grupo excipiente; ...

  18. 预扩张颈肩背反流轴型皮瓣及颈胸皮瓣联合修复颈侧部瘢痕挛缩畸形%THE USE OF PREFABRICATED EXPANDED CERVICO-SCAPULO-DORSAL REVERSE AXIAL FLAP COMBINED WITH CERVICO-THORACIC SKIN FLAP TO REPAIR CICATRICIAL CONTRACTURE OF LATERAL NECK

    Institute of Scientific and Technical Information of China (English)

    宋慧锋; 柴家科; 陈敏亮; 吴焱秋; 董巍; 张建林; 陈宝驹

    2003-01-01

    目的探讨采用预扩张颈肩背反流轴型皮瓣及颈胸皮瓣联合修复颈侧部瘢痕挛缩畸形的效果.方法对10例颈侧部瘢痕挛缩畸形患者先行患侧颈肩背反流轴型皮瓣及颈胸皮瓣预扩张,二期手术皮瓣转移修复颈侧部瘢痕切除后创面.结果本组10例患者术后皮瓣全部成活,颈侧部瘢痕挛缩畸形得到纠正,随访6~18个月,功能和外观良好.结论预扩张颈肩背反流轴型皮瓣联合颈胸皮瓣是修复颈侧部瘢痕挛缩畸形的一种理想方法.

  19. Retinopathy of prematurity in a controlled trial of prophylactic surfactant treatment.

    OpenAIRE

    Pennefather, P M; Tin, W.; Clarke, M P; Fritz, S.; Strong, N P

    1996-01-01

    AIMS: To investigate the incidence of acute and cicatricial retinopathy of prematurity (ROP) in a cohort of premature neonates entered into a randomised, multicentre trial of prophylactic exogenous surfactant for respiratory distress syndrome (RDS) compared with controls receiving surfactant only if severe RDS developed. METHODS: The incidence of acute and cicatricial ROP was assessed in 304 neonates born at less than 30 weeks' gestation in a geographically defined population of approximately...

  20. IMPORTANCE OF THE TRICHOSCOPY IN SCALP DYSESTHESIA

    Directory of Open Access Journals (Sweden)

    Maria Bibiana Leroux

    2013-10-01

    Full Text Available The trichoscopy has been incorporated as a first hand method in patients consulting for scalp problems. Magnifying glass or digital microscope that permit the direct visualization of the hair shaft and the perifolicullar skin are utilized to diagnose cicatricial and non-cicatricial alopecia. A female patient with an alopecia plaque associated with a scalp dysesthesia in which trichoscopy was very useful in its diagnosis is presented.

  1. Selenium toxicosis in a white-tailed deer herd

    OpenAIRE

    Al-Dissi, Ahmad N.; Blakley, Barry R.; Woodbury, Murray R.

    2011-01-01

    Chronic selenium (Se) toxicosis was found in a herd of white-tailed deer showing signs of anorexia, weight loss, and lameness. Concentration of Se in the liver ranged from 2.7 to 8.97 mg/kg wet weight. Myocardial necrosis, mineralization, and fibroplasia were seen histologically. This is the first report of this toxicosis in white-tailed deer.

  2. Neocolagenização induzida pelo resurfacing com laser erbium:YAG isolado e associado a lifting cutâneo: estudo morfométrico comparativo em ratos Comparison of single erbium:YAG laser resurfacing to a combination with cutaneous lifting: a morphometric study of neocollagenization in rats

    Directory of Open Access Journals (Sweden)

    Lucia Noronha

    2005-10-01

    Full Text Available INTRODUÇÃO: Diferente do lifting, cuja tração mecânica é a responsável pelo efeito clínico de rejuvenescimento sobre rugas profundas, a fibroplasia (ou neocolagenização é a responsável direta pelo resultado final da ação do laser sobre a pele com rugas superficiais, conferindo-lhe aparência mais jovem. O uso combinado dessas duas técnicas pode ser vantajoso, pois permite um resultado estético melhor com um único procedimento anestésico e cirúrgico em um curto período de recuperação. OBJETIVOS: O presente estudo morfométrico se propõe a avaliar se ocorre alguma alteração na espessura da fibroplasia induzida pelo resurfacing a laser erbium:YAG quando este se associa ao lifting cutâneo. MÉTODO: Foram utilizados 50 ratos da linhagem Wistar, divididos em dois grupos de 25, sendo que o primeiro grupo foi submetido à aplicação exclusiva de laser erbium:YAG no dorso de cada animal e o outro sofreu a aplicação de laser Erbium: YAG combinada ao lifting, o qual foi representado, no animal de experimentação, por retalho cutâneo dorsal pediculado. A fibroplasia foi avaliada nos dois grupos com medidas morfométricas lineares realizadas após o sacrifício dos animais nos dias 14, 28, 56, 84 e 112 do pós-operatório. RESULTADO: Foi observado aumento da fibroplasia em ambos os grupos estudados, porém o crescimento do colágeno foi superior no grupo submetido à terapia isolada com laser Erbium: YAG. CONCLUSÃO: A espessura da fibroplasia induzida pelo resurfacing a laser Erbium: YAG foi influenciada pela associação de um segundo procedimento cirúrgico no mesmo tempo operatório, neste caso, o lifting cutâneo.INTRODUCTION: The fibroplasia is the responsible for the final aesthetic results induced by laser resurfacing upon skin with superficial wrinkles. On the other hand, the lifting is responsible for the deeper wrinkles removal, produced by mechanic results. The use of the combination of these two rejuvenation

  3. Extrato de Passiflora edulis na cicatrização de feridas cutâneas abertas em ratos: estudo morfológico e histológico Extract from Passiflora edulis on the healing of open wounds in rats: morphometric and histological study

    Directory of Open Access Journals (Sweden)

    Inaldo de Castro Garros

    2006-01-01

    Full Text Available INTRODUÇÃO: Nas regiões interioranas do Brasil o cataplasma feito com folhas de Passiflora edulis tem sido usado pela população como cicatrizante, para tratar infecções e inflamações cutâneas, sem a comprovação científica dos seus potenciais benefícios. OBJETIVO: Avaliar a cicatrização de feridas abertas em ratos com a aplicação tópica de extrato hidroalcoólico de Passiflora edulis. MÉTODOS: Foram utilizados 60 ratos da linhagem Wistar, machos, adultos, divididos em dois grupos: o grupo Passiflora e o grupo Controle. Os animais do primeiro grupo foram tratados com o extrato de Passiflora edulis, e os do segundo grupo, com água destilada. A aplicação diária do extrato e da água destilada foi realizada sobre ferida circular padronizada de 2cm de diâmetro na região dorsal de cada animal. A avaliação da ferida foi feita do ponto de vista macro e microscópico nos períodos pré-determinados (7º, 14º e 21º dias. Fez-se a análise macroscópica da evolução do aspecto da lesão e medida da retração cicatricial da ferida, por planimetria digital. O estudo histológico em lâminas coradas pela Hematoxilina-Eosina e Tricômico de Masson considerou os parâmetros de elementos celulares inflamatórios incluindo colagenização e reepitelização. RESULTADOS: Não houve diferença estatisticamente significante entre as áreas cirúrgicas das feridas tratadas com Passiflora edulis e o grupo Controle; entretanto, histologicamente houve colagenização significantemente maior no 14º dia de pós-operatório nos animais do grupo Passiflora (p = 0,012. CONCLUSÕES: O uso tópico do extrato de Passiflora edulis não apresenta macroscopicamente efeito significativo na cicatrização de feridas na pele de ratos; entretanto microscopicamente apresenta aumento da proliferação fibroblástica no 7º dia e colagenização maior no 14º dia de pós-operatório.INTRODUCTION: In Brazilian countryside, cataplasm made from Passiflora

  4. Fibromuscular dysplasia

    OpenAIRE

    Jeunemaitre Xavier; Gimenez-Roqueplo Anne-Paule; Boutouyrie Pierre; Perdu Jérôme; La Batide-Alanore Agnès; Plouin Pierre-François

    2007-01-01

    Abstract Fibromuscular dysplasia (FMD), formerly called fibromuscular fibroplasia, is a group of nonatherosclerotic, noninflammatory arterial diseases that most commonly involve the renal and carotid arteries. The prevalence of symptomatic renal artery FMD is about 4/1000 and the prevalence of cervicocranial FMD is probably half that. Histological classification discriminates three main subtypes, intimal, medial and perimedial, which may be associated in a single patient. Angiographic classif...

  5. Treatment of hypertension in patients with renal artery stenosis due to fibromuscular dysplasia of the renal arteries

    OpenAIRE

    Chrysant, Steven G; Chrysant, George S.

    2014-01-01

    Renal artery stenosis (RAS) from fibromuscular dysplasia (FMD) is an uncommon cause of hypertension that affects mostly women. FMD is a noninflammatory vascular disease that predominantly affects mainly the renal arteries, but can also affect arteries in other vascular territories. The most common type of FMD is the media fibroplasia with the characteristic “string of beads” appearance (80-90%), whereas the two other types, the “intimal” and “adventitial” FMD are much less common accounting f...

  6. A Novel Technique for Repositioning Lower Eyelid Fat via the Transoral Approach in Association with Midface Lift

    OpenAIRE

    Mofid, M. Mark

    2011-01-01

    Background Orbital fat repositioning in association with subperiosteal midface elevation has been variably described via both the transconjunctival and skin muscle flap approaches. Poor visualization, middle and posterior lamellar cicatricial fibrosis, technical difficulty, and incomplete release are disadvantages commonly ascribed to the transconjunctival approach. Lower eyelid malposition and retraction also are commonly seen in association with skin muscle flap approaches. A simple techniq...

  7. Systemic sarcoidosis with necrobiosis lipoidica-like scalp lesions

    DEFF Research Database (Denmark)

    Andersen, Klaus Ejner

    1977-01-01

    A 78-year-old woman is described, having systemic sarcoidosis for 15 years, involving the lungs, lymph nodes and the skin. Over the last 6 years she developed a progressive cicatricial alopecia with histologic changes of the granulomatous type of necrobiosis lipoidica surrounded by sarcoid...

  8. [Humoral nonspecific immunity in patients with post-burn cicatrical strictures of the esophagus].

    Science.gov (United States)

    Mumladze, R B; Babaian, S S; Bobkov, Iu I; Chernyshev, V S; Taratuta, O V

    1983-03-01

    The authors have studied the significance of factors of the humoral non-specific defense (HND) in 37 patients with cicatricial constrictions of the oesophagus and stomach. The data obtained were used for choosing the optimum terms for gastrostoma and oesophagoplasty. In 14 patients treatment with lysozyme was performed due to decreased indices of HND. PMID:6857955

  9. Sutureless limited vitrectomy for positive vitreous pressure in cataract surgery.

    Science.gov (United States)

    Chalam, Kakarla V; Gupta, Shailesh K; Agarwal, Swati; Shah, Vinay A

    2005-01-01

    A sutureless transconjunctival pars plana vitrectomy with the 25-gauge transconjunctival vitrectomy system is used to facilitate phacoemulsification in eyes with positive posterior vitreous pressure and shallow anterior chamber. Peribulbar local anesthesia is administered. In eyes with shallow anterior chamber, if an injection of a viscoelastic substance through anterior chamber paracentesis fails to deepen the anterior chamber, a limited pars plana vitrectomy is performed to remove a small amount of retro-lental vitreous (approximately 0.2 to 0.3 cc) with a 25-gauge high-speed cutter. Phacoemulsification is subsequently performed. The limited pars plana vitrectomy reduces the chances of intraoperative vitreous loss and suprachoroidal hemorrhage. It also increases the anterior chamber depth, facilitates intraoperative steps such as pupil stretching and capsulorhexis, and results in a phacoemulsification procedure that is less complex and safer. PMID:16355960

  10. 早产儿视网膜病变

    Institute of Scientific and Technical Information of China (English)

    李嵘; 古丽苏玛依·热合曼; 苟春平

    2004-01-01

    早产儿视网膜病变(Reti no Pathy of Prematurity,RoP)是影响未成熟婴儿视网膜血管的一种病变,表现为视网膜缺血,新生血管形成和增殖性视网膜病变,重症者可引起视网膜脱离导致失明。以往传统称为晶体后纤维增生症(Retrolental Fibrop lasia),这一名称只概括了本病的晚期病变,不能包括本病急性期的表现。该病于1942年首先由Terry报告。1951年Campbe儿发现与患儿大量吸氧有关。

  11. [Intraocular Inflammation: Autoimmune or Infectious?].

    Science.gov (United States)

    Auw-Hädrich, C; Heinzelmann, S; Coupland, S

    2016-07-01

    Presentation of 3 cases of intraocular inflammation: 1. 47-year old female patient with severe necrotising scleritis and uveitis with underlying granulomatous polyangiitis (formerly known as Wegener granulomatosis, in honour of the German pathologist Friedrich Wegener), known for 10 years. 2. 48-year old male patient with longstanding bilateral uveitis and granulomatous polyangiitis for 2 years. In the histopathological examination of the enucleation specimen, a retrolental tumour turned out to be a granuloma. 3. 57-year old male patient in status post renal transplantation with intraocular cellular infiltration suspicious for lymphoma, which surprisingly proved to be Toxoplasma gondii-associated uveitis. The clinical course and characteristic histological signs and therapeutic options are discussed. PMID:27468098

  12. A large unilateral renal artery aneurysm in a young child

    International Nuclear Information System (INIS)

    The case of a 13-month-old boy with fibromuscular dysplasia (FMD) presenting with a large saccular aneurysm of the left renal artery and renovascular hypertension is reported. Renal and intrarenal arteries showed numerous small aneurysms alternating with stenoses. All arterial lesions were localized to the left kidney. After left nephrectomy, the patient's blood pressure normalized. Histopathologic examination of the arteries disclosed changes typical of medial fibroplasias, the most frequently described form of FMD in children. This diagnosis is rewarding as it represents a surgically curable cause of severe hypertension. (orig.)

  13. Cardiomyopathy in ostriches (Struthio camelus) due to avocado (Persea americana var. guatemalensis) intoxication.

    Science.gov (United States)

    Burger, W P; Naudé, T W; Van Rensburg, I B; Botha, C J; Pienaar, A C

    1994-09-01

    Nine out of 120 ostriches died from congestive heart failure within 96 h of ingesting avocado leaves and immature fruit in an avocado orchard containing Hass and Fuerte cultivars. Foliage and immature fruit from both cultivars dosed to ostriches (n = 4) and domestic hens (n = 8) resulted in severe cardiomyopathy in all the ostriches. In the hens, which had received a lower dose, milder lesions occurred. Macroscopically the intoxication in ostriches resulted in a severe anasarca of the neck and ventral body. The cardiomyopathy was characterised by degeneration and necrosis of myocytes, a marked infiltration of heterophils and in one case, early fibroplasia.

  14. Alopecia: evaluation and treatment

    Directory of Open Access Journals (Sweden)

    Gordon KA

    2011-07-01

    Full Text Available Katherine A Gordon, Antonella TostiDepartment of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USAAbstract: Hair loss is a very common complaint. Patients may describe increased shedding and diffuse or localized alopecia. The differential diagnosis of hair loss includes a number of disorders causing cicatricial or noncicatricial alopecias. This paper describes the clinical approaches and diagnostic tests that are useful in the evaluation of patients presenting with alopecia. It also reviews treatments for noncicatricial alopecias, including androgenetic alopecia, alopecia areata, and telogen effluvium, as well as cicatricial alopecias, including lichen planopilaris, its clinical variant frontal fibrosing alopecia, and discoid lupus erythematosus.Keywords: alopecia, evaluation, treatment

  15. Transplante de membrana amniótica Amniotic membrane transplantation

    Directory of Open Access Journals (Sweden)

    Hamilton Moreira

    2000-08-01

    Full Text Available O transplante de membrana amniótica tem sido utilizado como alternativa para a reconstrução da superfície ocular em substituição ao tecido conjuntival nos casos de doenças cicatriciais da córnea ou conjuntiva. Tem sido descrito na literatura para o tratamento de defeitos epiteliais persistentes, pterígio recidivado, Síndrome de Stevens-Johnson e Penfigóide cicatricial, queimaduras químicas e ceratopatia bolhosa.Amniotic membrane transplantation has been used as an alternative for ocular surface reconstruction. Indications for amniotic membrane transplantation include persistent epithelial defects, pterygium, Stevens-Johnson syndrome, ocular cicatricial pemphigoid, chemical burns and pseudo-phakik bullous keratopathy.

  16. The use of autogenous fascia lata to correct lid and orbital deformities.

    OpenAIRE

    Flanagan, J C; Campbell, C. B.

    1981-01-01

    Autogenous and homologous fascia lata have been used to correct many problems in ophthalmic surgery. This paper has described the use of autogenous fascia late to correct lid retraction secondary to thyroid ophthalmopathy, cicatricial entropion and extruding orbital implants. The surgical procedures have been briefly discussed, as well as the presentation of one clinical example of each procedure the pathologic and immunologic aspects of fascia lata grafts will be reported at a later date.

  17. Therapy of Chronic Cardiosclerosis in WAG Rats Using Cultures of Cardiovascular Cells Enriched with Cardiac Stem Cell.

    Science.gov (United States)

    Chepeleva, E V; Pavlova, S V; Malakhova, A A; Milevskaya, E A; Rusakova, Ya L; Podkhvatilina, N A; Sergeevichev, D S; Pokushalov, E A; Karaskov, A M; Sukhikh, G T; Zakiyan, S M

    2015-11-01

    We developed a protocol for preparing cardiac cell culture from rat heart enriched with regional stem cells based on clonogenic properties and proliferation in culture in a medium with low serum content. Experiments on WAG rats with experimental ischemic myocardial damage showed that implantation of autologous regional stem cells into the left ventricle reduced the volume of cicatricial tissue, promoted angiogenesis in the damaged zone, and prevented the risk of heart failure development.

  18. Метод лікування застарілого вивиху плеча репозиційною системою зовнішньої черезкісткової фіксації

    OpenAIRE

    Shyika, Andrey; Klepach, Mykola; Bobyk, Vasil

    2009-01-01

    Neglected shoulder dislocation is a difficult orthopaedic pathology and makes 23.7-25.0 % of all dislocations of the shoulder. Closed reduction of shoulder dislocations without complications is actually impossible because of significant cicatricial changes in the shoulder joint capsule and adjacent anatomical formations. Therefore open reduction becomes necessary, but it often results in disruption of the shoulder joint function. The authors developed a method of closed reduction for neglecte...

  19. Frontal Fibrosing Alopecia in a Male Presenting with Sideburn Loss

    OpenAIRE

    AlGaadi, Salim; Miteva, Mariya; Tosti, Antonella

    2015-01-01

    Frontal fibrosing alopecia (FFA) is a cicatricial alopecia that affects mainly postmenopausal women. It is typically characterized by recession of frontotemporal hairline. Hair loss of eyebrows, eyelashes, axillae, limbs, and pubic area may be observed. Here, we describe a case of FFA in a male patient presenting with only localized loss of sideburns. Skin biopsy findings were consistent with lichen planopilaris. To our knowledge, this is the only reported case of FFA patient with only locali...

  20. Beard reconstruction using hair grafts in a free flap

    OpenAIRE

    Levesque, Andre Y; Schalet, Benjamin J; Dolph, James L

    2011-01-01

    Hair transplantation using micrografts or minigrafts is a standard procedure used for hair restoration in androgenic, burn scar and cicatricial alopecia. These grafts have also been used to reconstruct the eyebrow, eyelash, mustache, beard and pubic escutcheon. A patient who underwent successful micrograft and minigraft hair transplantation into a free osteocutaneous mandibular flap reconstruction is presented. The patient was very satisfied with his reconstruction, and the hair transplants p...

  1. Frontal Fibrosing Alopecia in a Male Presenting with Sideburn Loss.

    Science.gov (United States)

    AlGaadi, Salim; Miteva, Mariya; Tosti, Antonella

    2015-01-01

    Frontal fibrosing alopecia (FFA) is a cicatricial alopecia that affects mainly postmenopausal women. It is typically characterized by recession of frontotemporal hairline. Hair loss of eyebrows, eyelashes, axillae, limbs, and pubic area may be observed. Here, we describe a case of FFA in a male patient presenting with only localized loss of sideburns. Skin biopsy findings were consistent with lichen planopilaris. To our knowledge, this is the only reported case of FFA patient with only localized loss of sideburns. PMID:26180452

  2. Alopecia: evaluation and treatment

    OpenAIRE

    Gordon KA; Tosti A

    2011-01-01

    Katherine A Gordon, Antonella TostiDepartment of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USAAbstract: Hair loss is a very common complaint. Patients may describe increased shedding and diffuse or localized alopecia. The differential diagnosis of hair loss includes a number of disorders causing cicatricial or noncicatricial alopecias. This paper describes the clinical approaches and diagnostic tests that are useful in the evaluation of patie...

  3. Abbreviations

    OpenAIRE

    2013-01-01

    ACAME Association des centrales d’achat de médicaments essentiels (Association of central medical stores for essential generic drugs) AMPOT Association malienne pour la promotion des ophtalmologues traditionnels (Malian association for the promotion of traditional ophthalmologists) CT Cicatricial (scar) trachoma DALY Disability Adjusted Life-Years DDT Dichlorodiphenyltrichloroethane DMT Department of traditional medicine DOTS Directly Observed Therapy Short Course FT Follicular trachoma GIS G...

  4. The ecology of trachoma: an epidemiological study in southern Mexico

    OpenAIRE

    Taylor, Hugh R.; Velasco, Francisco M.; Sommer, Alfred

    1985-01-01

    A total of 1097 people in two communities in Chiapas, Mexico, were examined for trachoma, and information was obtained about personal and family hygiene. Trachoma was hyperendemic; approximately 25% of those under 10 years old were found to have significant inflammatory trachoma and almost 100% of those aged over 40 years had cicatricial trachoma, although the prevalence of trachoma differed significantly between the two communities. Risk factor analysis was performed by contingency table ana...

  5. Ocular Graft Versus Host Disease Following Allogeneic Stem Cell Transplantation: A Review of Current Knowledge and Recommendations

    OpenAIRE

    Nariman Nassiri; Medi Eslani; Nekoo Panahi; Shiva Mehravaran; Alireza Ziaei; Djalilian, Ali R.

    2013-01-01

    Graft versus host disease (GVHD) is a common complication of allogeneic stem cell transplantation (allo-SCT). Ocular GVHD develops in approximately 40-60% of patients following allo-SCT and its most common clinical manifestations include keratoconjunctivitis sicca and cicatricial conjunctivitis. Ocular GVHD may lead to severe ocular surface disease, which can significantly diminish quality of life and restrict daily activities. It is thus important to monitor the condition closely since with ...

  6. Thermal Imaging Assessment of Cicatrical Tissue Capabilities in Facioplasty Planning

    OpenAIRE

    N.L. Korotkova; М.G. Volovik

    2015-01-01

    The aim of the investigation was to study the capabilities of thermal imaging to estimate the functional reserves of blood supply of facial cicatricial tissues used in skin grafting. Materials and Methods. Using an infrared thermal imager Thermo Tracer ТН-9100 we examined 37 patients with post-burn scars on the face and anterior surface of the neck (total: 126 scar areas planned for flap dissection) and 4 healthy volunteers. After recording a native (original) thermal picture, we carried ...

  7. Thermal Imaging Assessment of Cicatrical Tissue Capabilities in Facioplasty Planning

    Directory of Open Access Journals (Sweden)

    N.L. Korotkova

    2015-06-01

    Full Text Available The aim of the investigation was to study the capabilities of thermal imaging to estimate the functional reserves of blood supply of facial cicatricial tissues used in skin grafting. Materials and Methods. Using an infrared thermal imager Thermo Tracer ТН-9100 we examined 37 patients with post-burn scars on the face and anterior surface of the neck (total: 126 scar areas planned for flap dissection and 4 healthy volunteers. After recording a native (original thermal picture, we carried out a standard local alcohol test with further monitoring of space-time temperature dynamics for 7 min. To develop a criterion of tissue suitability for skin grafting, we calculated ∆Т=Тinit–Тfin, where Тinit was the initial temperature before the test, and Тfin — the temperature on the 7th minute of test recovery. Results. The obtained data on the thermal reaction dynamics of cicatricial tissues enable to evaluate the capability to use these tissues as skin grafting material. The criteria are based on thermal imaging findings of the dynamics of initial temperature recovery of healthy and cicatrical tissues. If the temperature difference by the 7th minute of the examined tissues is below 0.9°С by the end of the alcohol test, the tissues can be used for skin grafting. The temperature recovery lag by more than 1.9°С indicates inapplicability of cicatricial tissues for skin grafting. The temperature difference in the range from 0.9 to 1.9°С should be considered risky. Conclusion. The developed thermal image technique to assess the functional state of facial cicatricial tissue blood supply enables to determine the criteria of cicatrical tissue availability for minor facioplasty, and differentiate suitable and unsuitable tissues.

  8. Informative value of MR tomography using gadolinium-DTPA in the diagnosis of the lumbar post-discotomy syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Beyer, H.K.; Hoetzinger, H.; Toedt, C.; Oppel, U.

    1989-03-01

    Our results have shown that MR tomography - especially if gadolinium-DTPA is used as a contrast medium - is an excellent method to differentiate between the various possible causes of the post-discotomy syndrome. In particular, it is definitely possible to differentiate between a relapsed hernia of an intervertebral dis and a postoperative development of cicatricial tissue which is practically inevitable. This differentiation is of vital importance to the clinician, because a second operation should be performed only in case of a relapse, whereas cicatricial tissue is best left alone, because no matter how carefully the operation is performed with preparation of the neural structures, even more extensive cicatricial plates are bound to develop. Instability of the vertebral column in the operated disc segment, or other causes of complaints, can be identified via MR equally well if not better than by other means. Hence, the method should be the method of choice in postdiscotomy syndrome, since it facilitates the difficult choice between conservative therapy and reoperation.

  9. Stevens-Johnson syndrome: The role of an ophthalmologist.

    Science.gov (United States)

    Jain, Rajat; Sharma, Namrata; Basu, Sayan; Iyer, Geetha; Ueta, Mayumi; Sotozono, Chie; Kannabiran, Chitra; Rathi, Varsha M; Gupta, Nidhi; Kinoshita, Shigeru; Gomes, José A P; Chodosh, James; Sangwan, Virender S

    2016-01-01

    Stevens-Johnson syndrome (SJS) is an acute blistering disease of the skin and mucous membranes. Acute SJS leads to the acute inflammation of the ocular surface and chronic conjunctivitis. If not properly treated, it causes chronic cicatricial conjunctivitis and cicatricial lid margin abnormalities. Persistent inflammation and ulceration of the ocular surface with cicatricial complications of the lids leads to chronic ocular sequelae, ocular surface damage, and corneal scarring. The destruction of the glands that secrete the tear film leads to a severe form of dry eye that makes the management of chronic SJS difficult. The option that is routinely used for corneal visual rehabilitation, keratoplasty, is best avoided in such cases. We describe the management strategies that are most effective during the acute and chronic stages of SJS. Although treatments for acute SJS involve immunosuppressive and immunomodulatory therapies, amniotic membrane transplantation is also useful. The options for visual rehabilitation in patients with chronic SJS are undergoing radical change. We describe the existing literature regarding the management of SJS and highlight recent advances in the management of this disorder. PMID:26829569

  10. Chitosan-alginate membranes accelerate wound healing.

    Science.gov (United States)

    Caetano, Guilherme Ferreira; Frade, Marco Andrey Cipriani; Andrade, Thiago Antônio Moretti; Leite, Marcel Nani; Bueno, Cecilia Zorzi; Moraes, Ângela Maria; Ribeiro-Paes, João Tadeu

    2015-07-01

    The purpose of this study was to evaluate the efficacy of chitosan-alginate membrane to accelerate wound healing in experimental cutaneous wounds. Two wounds were performed in Wistar rats by punching (1.5 cm diameter), treated with membranes moistened with saline solution (CAM group) or with saline only (SL group). After 2, 7, 14, and 21 days of surgery, five rats of each group were euthanized and reepithelialization was evaluated. The wounds/scars were harvested for histological, flow cytometry, neutrophil infiltrate, and hydroxyproline analysis. CAM group presented higher inflammatory cells recruitment as compared to SL group on 2(nd) day. On the 7(th) day, CAM group showed higher CD11b(+) level and lower of neutrophils than SL group. The CAM group presented higher CD4(+) cells influx than SL group on 2(nd) day, but it decreased during the follow up and became lower on 14(th) and 21(st) days. Higher fibroplasia was noticed on days 7 and 14 as well as higher collagenesis on 21(st) in the CAM group in comparison to SL group. CAM group showed faster reepithelialization on 7(th) day than SL group, although similar in other days. In conclusion, chitosan-alginate membrane modulated the inflammatory phase, stimulated fibroplasia and collagenesis, accelerating wound healing process in rats.

  11. Associação fitoterápica no tratamento de feridas cutâneas induzidas em equinos

    Directory of Open Access Journals (Sweden)

    G. Ribeiro

    2013-10-01

    Full Text Available Estudou-se a eficácia do uso tópico de um produto comercial constituído por uma associação fitoterápica como promotor da cicatrização de feridas induzidas em equinos. Uma lesão cutânea em forma de quadrado, com 5cm de lado, foi produzida cirurgicamente em ambos os lados da região glútea de oito cavalos adultos. Aleatoriamente um dos lados foi escolhido como tratado, permanecendo o contralateral como controle. As lesões do lado controle foram lavadas com água e detergente neutro e, no lado tratado, foi realizado o mesmo procedimento, seguido de aplicação tópica da associação fitoterápica. As evoluções macroscópica e microscópica do processo cicatricial foram avaliadas, e a área de cada ferida determinada no decorrer do período experimental. Foram encontradas diferenças significativas entre os lados em relação aos valores de área das feridas. Na última avaliação, o lado controle apresentou valor médio de área de 0,70cm², e o lado tratado de 1,23cm². A contração cicatricial observada em 77 dias de evolução cicatricial foi de 97,57% para o lado controle e de 95,59% para o lado tratado.

  12. Alopecia frontal fibrosante: relato de seis casos Frontal fibrosing alopecia: report of six cases

    OpenAIRE

    Fabiane Mulinari-Brenner; Fernanda Manfron Rosas; Maurício Shigueru Sato; Betina Werner

    2007-01-01

    Alopecia frontal fibrosante é forma progressiva de alopecia cicatricial. Os casos iniciais foram relatados a partir 1994, na Austrália, em pacientes do sexo feminino pós-menopausa. Desde então inúmeros casos foram descritos na literatura sugerindo que ela é mais prevalente do que inicialmente se supunha. Seu curso progressivo se assemelha ao da alopecia androgenética; histologicamente, entretanto, o infiltrado liquenóide é evidente. O artigo relata seis casos brasileiros e discute a alopecia ...

  13. O autocuidado para o tratamento de úlcera de perna falciforme: orientações de enfermagem

    OpenAIRE

    Amanda Martins; Debora Galvão Moreira; Emilia Matos do Nascimento; Enedina Soares

    2013-01-01

    O objetivo deste estudo foi verificar a eficácia do Programa do Autocuidado, pela progressão do processo cicatricial de úlcera da perna falciforme. Trata-se de um estudo longitudinal com abordagem quantitativa realizado com 40 clientes no setor de curativos de uma instituição de saúde pública, especializada no tratamento hematológico, situada no Rio de Janeiro. Para a coleta dos dados foi utilizado um instrumento aplicado no momento das consultas de enfermagem. Os dados foram analisados com o...

  14. Fixação esquelética externa tipo Ia (unilateral-uniplanar) para osteossíntese diafisária de úmero em pombos domésticos (Columba livia) Type Ia (unilateral-uniplanar) external Skeletal fixation for treatment of humeral diaphysis fracture in domestic pigeons (Columba livia)

    OpenAIRE

    Alessandro Moraes Leotte; Alceu Gaspar Raiser; Fabricio Arygoni Braga; Luciene Krauspenhar; Sheyla Francheska Camargo; Fabiola Niederauer Flores; Kléber Gomes; Ricardo Simões Scherer

    2004-01-01

    Das várias patologias que podem acometer as aves, são mais freqüentes as fraturas de ossos longos das asas e dos membros pélvicos. Este experimento teve como objetivo observar, por meio de exames clínicos, histológicos e radiográficos, a resposta cicatricial óssea ao uso do fixador externo tipo Ia (unilateral-uniplanar) na redução aberta de fratura diafisária, de úmero em pombos domésticos (Columba livia). Foram estudados 14 pombos com peso variando entre 290 e 420 gramas. A fratura foi reali...

  15. Crecimiento maxilar según severidad de hendidura labial, alveolar y palatina unilateral Maxillary growth according to the severity of unilateral cleft lip and palate

    OpenAIRE

    M.C. Navas-Aparicio

    2012-01-01

    La inhibición del crecimiento y desarrollo resultante del tratamiento quirúrgico en pacientes con labio y paladar hendido es un tema ampliamente discutido en el mundo. De acuerdo a la literatura, la deficiencia de tejidos, probablemente debida al ancho y la posición del segmento alveolar en la hendidura, es una variable a considerar que afecta al crecimiento del maxilar, el cual también puede verse influido por la corrección quirúrgica del labio, la nariz y el paladar, por tejido cicatricial,...

  16. The Contributions of Gamma Probe to Lesion Detectability and Surgical Safety in Recurrent Thyroid Cancer at Risk

    Directory of Open Access Journals (Sweden)

    Salih Sinan Gültekin

    2013-08-01

    Full Text Available In patients, who underwent thyroid surgery or treated with I-131 radioiodine previously for differentiated thyroid cancer, a second surgical intervention carries higher risks due to distortion of the natural anatomy and development of fibrotic/cicatricial tissue. In addition, accurate assessment of current status about extent of the disease is important in terms of success of the surgery. In this case report, we present the positive contribution of intraoperative gamma probe used for lesion detectability and for surgical safety in a patient operated for several times and administered high cumulative dose of radioiodine therapy for diffentiated thyroid carcinoma previously.

  17. The large eyes of Wolfgang Amadeus Mozart. (On the occasion of the 250th Mozart anniversary year).

    Science.gov (United States)

    Zegers, Richard H C; Saeed, Peerooz; Wiersinga, Wilmar M

    2005-12-01

    This article discusses the eyes of Wolfgang Amadeus Mozart (1756-1791) which, based on portraits, can be said to have a certain noticeable feature--some degree of exophthalmos. In fact, even contemporary observers made particular mention of Mozart's eyes being large. Although cicatricial ectropion, caused by infectious disease, cannot be excluded, mild myopia, in combination with shallow orbits or combined with a genetic predilection, would be one possible explanation for Mozart's large eyes. Graves' orbitopathy, the ophthalmic manifestation of hyperthyroidism, or hypothyroidism have both been suggested to be the cause of Mozart's large eyes. However, these diseases are unlikely causes given their topical and systemic features.

  18. Bronchial asthma: correlation of high resolution computerized tomography findings with clinical data

    International Nuclear Information System (INIS)

    In this work we did a sectional study of 31 asthmatic patients with several levels of disease severity, which were submitted to high resolution computed tomography of the thorax and spirometry, between the months of July, 1995 and August, 1997. The tomographic findings were correlated with the clinical classification of the patients and the most frequent tomographic findings were bronchial wall thickening, bronchial dilatation, air trapping, centrilobular opacities, cicatricial linear shadows, mucoid impaction, emphysema and atelectasis. In asthmatic patients of long duration we observed small airway disease and irreversible lesions as the predominant findings. In smoking patients there was no high frequency of emphysema. (author)

  19. Imposters of androgenetic alopecia: diagnostic pearls for the hair restoration surgeon.

    Science.gov (United States)

    Rogers, Nicole

    2013-08-01

    It is crucial that hair restoration surgeons understand the basic clinical diagnosis and pathologic condition of other hair loss conditions that are not always amenable to successful hair transplantation. In this article nonscarring and scarring mimickers of androgenetic alopecia are discussed. Nonscarring conditions include alopecia areata, telogen effluvium, and tinea capitis. Some of the more common scarring alopecias include lichen planopilaris, frontal fibrosing alopecia, and central centrifugal cicatricial alopecia. Less common inflammatory conditions include pseudopelade of Brocq, discoid lupus erythematosus, and folliculitis decalvans. PMID:24017974

  20. Erosive pustular dermatosis of the scalp following hair transplantation

    Directory of Open Access Journals (Sweden)

    Zabihollah Shahmoradi

    2014-01-01

    Full Text Available Erosive pustular dermatosis of the scalp (EPDS is a rare inflammatory disease with unknown etiology that usually occurs in the elderly. It is characterized by multiple sterile pustules, chronic crusted erosions, cicatricial alopecia, and skin atrophy. It typically develops in aged or sun-damaged skin and is most often accompanied by a history of local trauma. Histopathologically, non-specialized change manifests as atrophic epidermis and chronic inflammation. Although this disease mainly occurs in elderly white women, we here report a case of EPDS in a 35-year-old man, following hair transplantation as a local trauma, that was successfully treated with topical steroid.

  1. Familial incidence of pseudopelade of brocq

    Directory of Open Access Journals (Sweden)

    Sharma D

    1993-01-01

    Full Text Available Pseudopelade of Brocq is an asymptomatic, beginning insidiously with small, white, depressed, bald spots, devoid of normal hair that mark the borders of some of the earlier lesions with atrophy and minimal perifollicular erythema, if at all. We report here a family of 3 members (2 brothers and 1 sister with similar findings of cicatricial alopecia for more than 10 years duration but without any cause which may lead to scarring and loss of hair of primary type of pseudopelade. To the best of our knowledge no familial incidence of pseudopelade has been reported any where in the literature so far.

  2. Bronchial asthma: correlation of high resolution computerized tomography findings with clinical data; Asma bronquica: correlacao de achados em tomografia computadorizada de alta resolucao com dados clinicos

    Energy Technology Data Exchange (ETDEWEB)

    Mogami, Roberto [Universidade do Estado, Rio de Janeiro, RJ (Brazil). Servico de Radiologia; Marchiori, Edson [Universidade Federal Fluminense, Niteroi, RJ (Brazil). Dept. de Radiologia; Kirk, Kennedy; Capone, Domenico [Universidade do Estado, Rio de Janeiro, RJ (Brazil). Servico de Pneumologia; Daltro, Pedro [Instituto Fernandes Figueira, Rio de Janeiro, RJ (Brazil). Servico de Radiologia

    1999-04-01

    In this work we did a sectional study of 31 asthmatic patients with several levels of disease severity, which were submitted to high resolution computed tomography of the thorax and spirometry, between the months of July, 1995 and August, 1997. The tomographic findings were correlated with the clinical classification of the patients and the most frequent tomographic findings were bronchial wall thickening, bronchial dilatation, air trapping, centrilobular opacities, cicatricial linear shadows, mucoid impaction, emphysema and atelectasis. In asthmatic patients of long duration we observed small airway disease and irreversible lesions as the predominant findings. In smoking patients there was no high frequency of emphysema. (author)

  3. Myopia in premature babies with and without retinopathy of prematurity.

    OpenAIRE

    Nissenkorn, I; YASSUR;, Y.; Mashkowski, D; Sherf, I; Ben-Sira, I

    1983-01-01

    One hundred and fifty-five premature infants weighing 600-2000 g were followed up during 1974-80 for the presence of retinopathy of prematurity (ROP) and for the existence of myopia. 50% of the premature infants who had ROP were myopic, while only 16% myopic premature infants were found among those who did not have ROP. There was a positive correlation between the degree of myopia and the severity of cicatricial ROP. No difference existed in the frequency and degree of myopia between prematur...

  4. DISEASE CAUSED BY CHEMICAL AND PHYSICAL AGENTS

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    930437 A study on the pathologic changes andmechanism of radiation interstitial pneumonitis.BAI Yunhong(白蕴红),et al.Instit RadiationMed,Milit Acad Med Sci,Beijing,100000.Med JChin PLA 1993;18(1):14—18.The right or whole thorax of Wistar rat wasirradiated with Co γ—ray including single expo-sure(10,30, 50,70Gy)and fractional exposures(30,60Gy).Animals from each group were sac-rificed at 0.5,1,2,3,6,9,12 months after irradia-tion.Sections of lung were examined with lightmicroscopy(LM),electron microscopy(EM),histochemistry and morphometry.The pul-monary changes could be divided into four phas-es;exudation,granulation,fibroplasia and colla-genation.The four phases can exactly show.the

  5. 7, 8-dihydroxycoumarin improves neurological function in a mouse model of sciatic nerve injury

    Institute of Scientific and Technical Information of China (English)

    Jianshi Du; Qing Zhao; Yingli Zhang; Yu Wang; Ming Ma

    2012-01-01

    In the present study, a mouse model of sciatic nerve injury was treated with intraperitoneal injection of 7, 8-dihydroxycoumarin (10, 5, or 2.5 mg/kg per day). Western blot and real-time PCR results showed that growth associated protein 43 expression was significantly increased in the L4-6 segments of the spinal cord. The amplitude and velocity of motor nerve conduction in the sciatic nerve were significantly increased in model mice. In addition, the appearance of the myelin sheath in the injured sciatic nerve was regular, with an even thickness and clear outline, and the surrounding fibroplasia was not obvious. Our results indicate that 7, 8-dihydroxycoumarin can promote the repair of injured nerve by upregulating growth associated protein 43 expression in the corresponding spinal cord segments of mice with sciatic nerve injury.

  6. Hypereosinophilic paraneoplastic syndrome in a cat with intestinal T cell lymphosarcoma.

    Science.gov (United States)

    Barrs, V R; Beatty, J A; McCandlish, I A; Kipar, A

    2002-09-01

    A 10-year-old, neutered female, domestic shorthair cat was presented with a recent history of weight loss, polydipsia, diarrhoea and vomiting. On physical examination, intestinal thickening and mesenteric lymph node enlargement were apparent. Clinical investigations revealed peripheral blood eosinophilia, eosinophilic abdominal effusion and eosinophilic mesenteric lymphadenitis. There was a temporary response to treatment with glucocorticoids but signs progressed and the cat was euthanased. On histology, there was eosinophilic infiltration and fibroplasia of intestine and mesenteric lymph nodes. Large aggregates of neoplastic round cells in the intestine and lymph nodes were identified as T lymphocytes using immunohistochemistry. A diagnosis of intestinal T cell lymphosarcoma was made. This case demonstrates that hypereosinophilic paraneoplastic syndrome may occur in cats with lymphosarcoma. Eosinophil chemotaxis may be a response to the production of interleukin-5 by neoplastic lymphocytes. PMID:12238505

  7. Skin barrier in rosacea.

    Science.gov (United States)

    Addor, Flavia Alvim Sant'Anna

    2016-01-01

    Recent studies about the cutaneous barrier demonstrated consistent evidence that the stratum corneum is a metabolically active structure and also has adaptive functions, may play a regulatory role in the inflammatory response with activation of keratinocytes, angiogenesis and fibroplasia, whose intensity depends primarily on the intensity the stimulus. There are few studies investigating the abnormalities of the skin barrier in rosacea, but the existing data already show that there are changes resulting from inflammation, which can generate a vicious circle caused a prolongation of flare-ups and worsening of symptoms. This article aims to gather the most relevant literature data about the characteristics and effects of the state of the skin barrier in rosacea. PMID:26982780

  8. Emphysematous Eosinophilic Lymphangitis in the Ruminal Submucosa of Cattle.

    Science.gov (United States)

    Ohfuji, S

    2015-11-01

    Twenty cattle (14 Holstein-Friesian, 3 Japanese Black, 3 Aberdeen Angus) ranging in age from 3 months to 8 years exhibited, at slaughter, emphysematous thickening of the ruminal submucosa owing to the appearance of numerous, contiguous, small gas bubbles. Microscopic changes in the ruminal submucosa consisted of (1) multiple cystic (emphysematous) lymphangiectasis that was frequently lined or occluded by granulomatous inflammatory infiltrates including macrophages, multinucleate giant cells, and eosinophils; (2) intralymphatic phagocytosis by macrophages and giant cells of eosinophils that showed positive labeling with the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end-labeling assay; and (3) an inflammatory infiltrate extending from the area of lymphangitis into surrounding tissue, as well as edema, hemorrhage, fibrin exudation, fibroplasia, or capillary proliferation throughout the lesional submucosa. In addition, 15 (75%) of the cattle had globular leukocyte infiltrates in the mucosal epithelia of the rumen.

  9. The inflammatory stimulus of a natural latex biomembrane improves healing in mice

    Directory of Open Access Journals (Sweden)

    T.A.M. Andrade

    2011-10-01

    Full Text Available The aim of the present study was to compare healing obtained with biomembranes with the natural healing process (sham using biochemical and immunohistological assays. C57BL/6 mice were divided into 4 groups of 15 mice each and received different subcutaneous implants: natural latex biomembrane (NLB, denatured latex (DL, expanded polytetrafluorethylene (ePTFE, or sham. On the 2nd, 7th, and 14th days post-treatment, 5 mice per group were sacrificed and biopsied for the following measurements: oxidative stress based on malondialdehyde (MDA, myeloperoxidase (MPO and hydrogen peroxide by the method of ferrous oxidation-xylenol orange (FOX, as well as glutathione and total proteins; histological evaluation to enumerate inflammatory cells, fibroblasts, blood vessels, and collagen, and immunohistochemical staining for inducible nitric oxide synthase, interleukin-1β, vascular endothelial growth factor (VEGF, and transforming growth factor-β1 (TGF-β1. On day 2 post-treatment, NLB stimulated a dense inflammatory infiltrate mainly consisting of polymorphonuclear cells, as indicated by increased MPO (P < 0.05, but oxidative stress due to MDA was not observed until the 7th day (P < 0.05. The number of blood vessels was greater in NLB (P < 0.05 and DL (P < 0.05 mice compared to sham animals on day 14. NLB induced fibroplasia by day 14 (P < 0.05 with low expression of TGF-β1 and collagenesis. Thus, NLB significantly induced the inflammatory phase of healing mediated by oxidative stress, which appeared to influence the subsequent phases such as angiogenesis (with low expression of VEGF and fibroplasia (independent of TGF-β1 without influencing collagenesis.

  10. Ultrasonographic Feature of Persistent Hyperplastic Primary Vitreous

    Institute of Scientific and Technical Information of China (English)

    Andina Hu; Miner Yuan; Fang Liu; Yu Yang; Xiaoyan Ding; Xiaoqing Pei

    2014-01-01

    Purpose:To observe the ultrasonographic features of patients with persistent hyperplastic primary vitreous (PHPV). Methods: Thirty-two subjects (34 eyes) diagnosed with PH-PV were evaluated by ultrasonography. Results:.The ultrasonography demonstrated a retrolental mass extending from the optic disc to the posterior lens capsule, manifested as band,.regular triangle,.or inverted triangle shapes..The band-shaped echo was characterized as a linear band extended from the optic disc to the posterior lens cap-sule..The regular triangle-shaped echo was manifested as a membranous septum with a wide base extended from the optic disc to the posterior lens capsule, and the anterior part became narrower..The inverted triangle echo was characterized as a membranous septum with a narrow base extended from the optic disc to the posterior lens capsule,.and the anterior part become wider. Conclusion:.Ultrasonography is noninvasive and safe,.and can offer real-time display of intraocular structures. This is es-pecially important in individuals who are uncooperative or un-suitable for fundus examination due to media opacity. Com-bined with clinical feature, ultrasonography provides vital evi-dence for the diagnosis of PHPV..Thought observing ultra-sonographic feature, clinicians could evaluate the size, posi-tion and severity of lesions in PHPV patients,.and which would be helpful to determine the surgical approach and clini-cal prognosis.

  11. Controversies in intraocular lens implantation in pediatric uveitis.

    Science.gov (United States)

    Phatak, Sumita; Lowder, Careen; Pavesio, Carlos

    2016-12-01

    Cataract is one of the most common and visually debilitating complications of pediatric uveitis. It develops as a consequence of chronic inflammation and steroid use and is seen most often in juvenile idiopathic arthritis (JIA)-associated uveitis. Cataract extraction with intraocular lens (IOL) insertion has been carried out with a measure of success in non-uveitic pediatric eyes, but in cases of uveitis, multiple factors affect the final outcome. Chronic inflammation and its sequelae such as band keratopathy, posterior synechiae, and cyclitic membranes make surgical intervention more challenging and outcome less certain. Postoperative complications like increased inflammation, glaucoma, posterior capsular opacification, retrolental membranes, and hypotony may compromise the visual outcome. Early refractive correction is imperative in pediatric eyes to prevent amblyopia. The use of contact lenses and intraocular lenses in pediatric uveitic eyes were fraught with complications in the past. Surgical interventions such as vitreo-lensectomy followed by contact lens fitting and small incision cataract surgery followed by different types of intraocular lenses have been utilized, and many reports have been published, albeit in small patient groups. This review analyzes and discusses the existing literature on intraocular lens implantation in cases of pediatric uveitic cataract surgery. PMID:27009616

  12. Controversies in intraocular lens implantation in pediatric uveitis.

    Science.gov (United States)

    Phatak, Sumita; Lowder, Careen; Pavesio, Carlos

    2016-12-01

    Cataract is one of the most common and visually debilitating complications of pediatric uveitis. It develops as a consequence of chronic inflammation and steroid use and is seen most often in juvenile idiopathic arthritis (JIA)-associated uveitis. Cataract extraction with intraocular lens (IOL) insertion has been carried out with a measure of success in non-uveitic pediatric eyes, but in cases of uveitis, multiple factors affect the final outcome. Chronic inflammation and its sequelae such as band keratopathy, posterior synechiae, and cyclitic membranes make surgical intervention more challenging and outcome less certain. Postoperative complications like increased inflammation, glaucoma, posterior capsular opacification, retrolental membranes, and hypotony may compromise the visual outcome. Early refractive correction is imperative in pediatric eyes to prevent amblyopia. The use of contact lenses and intraocular lenses in pediatric uveitic eyes were fraught with complications in the past. Surgical interventions such as vitreo-lensectomy followed by contact lens fitting and small incision cataract surgery followed by different types of intraocular lenses have been utilized, and many reports have been published, albeit in small patient groups. This review analyzes and discusses the existing literature on intraocular lens implantation in cases of pediatric uveitic cataract surgery.

  13. Advances in diagnosis, clinical care, research, and treatment in retinopathy of prematurity

    Directory of Open Access Journals (Sweden)

    Hartnett ME

    2016-05-01

    Full Text Available M Elizabeth Hartnett,1–3 Antonio Capone Jr4,5 1Vitreoretinal Surgery, John A. Moran Eye Center, 2Department of Ophthalmology, 3Department of Neurobiology and Anatomy, and Pediatrics, University of Utah, Salt Lake City, UT, 4Associated Retina Consultants, Royal Oak, 5Department of Ophthalmology, Oakland University William Beaumont Hospital School of Medicine, Auburn Hills, MI, USAThe appearance of retinopathy of prematurity (ROP has changed throughout the world and since the first description of “retrolental fibroplasia” in 1942. However, despite advances in neonatal care and the abilities to improve the survival of ever younger and smaller premature infants, ROP remains a leading cause of childhood blindness worldwide. We know that ROP is complex in that it is influenced by genetic predisposition, epigenetic regulation, and environmental risks. It is strongly associated with extreme degrees of prematurity, and the “phenotype” of ROP depends on resources available to support premature infants with adequate nutrition and regulation of oxygen, as examples. New studies also suggest that what is seen in the preterm infant retina may portend later neurodevelopmental outcomes. Therefore, we believe this is a needed time to revisit ROP and provide a thematic issue focused on ROP from several perspectives.

  14. Aspectos celulares da cicatrização Cellular aspects of wound healing

    Directory of Open Access Journals (Sweden)

    Ricardo José de Mendonça

    2009-07-01

    Full Text Available O processo cicatricial compreende uma sequência de eventos moleculares e celulares que interagem para que ocorra a restauração do tecido lesado. Desde o extravasamento de plasma, com a coagulação e agregação plaquetária até a reepitelização e remodelagem do tecido lesado o organismo age tentando restaurar a funcionalidade tecidual. Assim, este trabalho abrange os diversos aspectos celulares envolvidos no processo cicatricial, bem como os principais medicamentos utilizados no tratamento de patologias relacionadas às deficiências na cicatrização. São abordados também, os aspectos econômicos referentes, sobretudo, às feridas crônicas de pés diabéticos.Wound healing is a dynamic interactive process that involves a sequence of molecular and cellular events. Recent advances in cellular and molecular biology have greatly expanded our understanding of the biological process involved in wound repair and tissue regeneration. From plasma extravasation, with coagulation and platelet aggregation, to reepithelialization and remodeling of injured tissue, the organism acts by trying to restore functionality tissue. Thus, the present study encompasses several cellular aspects involved in the wound healing process, as well as the main drugs used in treating the pathology related to wound healing complications. Economic aspects are also addressed, mainly related to chronic wounds of diabetic feet.

  15. Preventive effect of gelatinizedly-modified chitosan film on peritoneal adhesion of different types

    Institute of Scientific and Technical Information of China (English)

    Xie-Lai Zhou; Shan-Wen Chen; Guo-Dong Liao; Zhou-Jun Shen; Zhi-Liang Zhang; Li Sun; Yi-Jun Yu; Qiao-Ling Hu; Xiao-Dong Jin

    2007-01-01

    .378 ±0.043 μg/mg pr, P = 0.387; 4 wk: 0.370 ± 0.032 vs 0.367± 0.041 μg/mg pr, P = 0.853); Pathological changes:In group B, the main pathological changes were fibroplasias in the treated serous membrane surface and in group D, the fibroplasia was shown in the whole layer of the vermiform processes. In group E, the main pathological changes were acute and chronic suppurative inflammatory reactions. These changes were lighter in the experimental subgroups than those in the control subgroups in the three groups. In group C, the main changes were foreign body giant cell and granuloma reactions and fibroplasias in different degrees, with no apparent differences between the experimental and control subgroups.CONCLUSION: The gelatinizedly-modified chitosan film is effective on preventing peritoneal adhesions induced by wound, ischemia and infection, but the effect is not apparent in foreign body-induced adhesion.

  16. Recent advancement on autoantigens, autoantibodies and inflammatory cells in subepidermal autoimmune bullous diseases

    Institute of Scientific and Technical Information of China (English)

    Jianguo Huang; Qiying Gong; Guiming Li

    2007-01-01

    Subepidermal autoimmune bullous diseases (SABD) are some autoimmune skin diseases that can present in a variety of forms and can be a challenging disease to treat. An overview of the different forms of SABD are discussed including bullous pemphigoid (BP), epidermolysis bullosa acquisita (EBA), cicatricial pemphigoid (CP), bullous systemic lupus erythematosus (BSLE), and Anti-p200 pemphigoid. Emphasis on recent advancement is presented. In recent years, improved Knowledge of the mechanisms of intercellular and cell-matrix adhesion has led to better understanding of the blistering process in some SABD. Defects of such structures cause the subepidermal bullous diseases and have also led to the discovery of new diseases (e.g. anti-p200-pemphigoid). Recent studies have outlined the important role of autoantibodies, mast cell lymphocytes and their cytokines in pathogenesis of SABD.

  17. Multilayered pigment epithelial detachment in neovascular age-related macular degeneration

    DEFF Research Database (Denmark)

    Rahimy, Ehsan; Freund, K Bailey; Larsen, Michael;

    2014-01-01

    identified, and then correlated with visual outcome. RESULTS: Thirty-eight eyes of 34 patients with fibrovascular PEDs were included. Mean and median Snellen visual acuity was 20/50 (range, 20/20-20/400). Eyes received a mean of 28.2 intravitreal anti-VEGF injections (median, 23.0; range, 3-70) administered...... properties. An associated hyporeflective space, termed a "pre-choroidal cleft," separates the fusiform complex from the underlying choroid and may be due to contraction, the exudation of fluid, or both. Many of these eyes maintain good visual acuity, presumably because the neovascular and cicatricial process...... is suppressed within the sub-retinal pigment epithelium space by chronic anti-VEGF therapy, thus permitting the viability of the photoreceptor population through preservation of the retinal pigment epithelium....

  18. Clinical and morphological evaluation of snake venom derived fibrin glue on the tendon healing in dogs

    Directory of Open Access Journals (Sweden)

    G. C. Ferraro

    2005-12-01

    Full Text Available The aim of this study was to evaluate the effect of snake venom derived fibrin glue on the healing of the deep digital flexor tendon, during three periods. The tendon of the 2nd digit of 30 thoracic limbs of dogs was partially sectioned for glue application. Biopsies were performed 7, 15, and 30 days post surgery for the clinical and morphological study of tendons. Analysis of the results showed that 73.3% of the tendons showed stump retraction and 16.6% moderate to excessive adherence, which affected sliding. There was a significant difference in the number of inflammatory cells among the three studied periods, being the highest on day 15. The morphological analysis revealed a typical tendon healing process with a lower level of inflammation in the acute phase, facilitating the cicatricial maturation phase. Snake venom derived fibrin glue promotes the healing in dog flexor tendon.

  19. History of lumbar disc herniation with Gd-DPTA enhanced MRI

    Energy Technology Data Exchange (ETDEWEB)

    Iwahara, Toshihito; Satou, Toshikazu [Wakkanai Municipal Hospital, Hokkaido (Japan)

    1995-09-01

    The pathological changes of primary lumbar disc herniation was monitored on T1-weighted and Gd-weighted MR imagings. The subjects were 11 patients whose symptoms improved solely by conservative therapy. Herniated area on T1-weighted images (whole herniated area), enhanced herniated area on Gd-MRI (enhanced area), and non-enhanced herniated area on Gd-MRI (non-enhanced area) were calculated, and each proportion to the vertebral canal was assessed. Changes in herniated area was correlated with changes of enhanced area. Gd-MRI was found to be useful in predicting the prognosis of primary herniation, as well as in differentiating recurrent herniation and cicatricial tissues. (S.Y.).

  20. Perda pilosa por líquen plano pilar após transplante capilar: relato de dois casos e revisão da literatura Hair loss due to lichen planopilaris after hair transplantation: a report of two cases and a literature review

    OpenAIRE

    Márcio Rocha Crisóstomo; Manoela Campos Cavalcante Crisóstomo; Marília Gabriela Rocha Crisóstomo; Victor José Timbó Gondim; Mara Rocha Crisóstomo; André Nunes Benevides

    2011-01-01

    Alopecia androgenética é tratada com frequência por meio de microtransplante capilar, téc nica em que os fios transplantados geralmente não caem, pois mantêm características da área doadora, mais resistente. O líquen plano pilar é uma alopecia cicatricial com permanente destruição pilosa. Este artigo relata dois casos de lesões compatíveis com líquen plano pilar em áreas receptora e doadora póstransplante. A dominância da área doadora foi aparentemente sobrepujada pelo líquen plano pilar, que...

  1. Myofibroblasts in fibromatoses. An electron microscopic study.

    Science.gov (United States)

    Kiryu, H; Tsuneyoshi, M; Enjoji, M

    1985-05-01

    Fifteen cases of fibromatoses were analyzed by electron microscopy, the objective being to compare the incidence and frequency of myofibroblasts in each category. Myofibroblasts were identified in all 15 cases and a considerably large number of these cells appeared in palmar fibromatosis, plantar fibromatosis, and nodular fasciitis. In keloid and cicatricial fibromatosis, however, only a small number of these cells were evident. In seven cases of extra-abdominal desmoid fibromatosis, the frequency of myofibroblasts in the component cells ranged from 10% to 64%, with a mean of 30%. The frequency was high in hypercellular lesions and low in hypocellular lesions, assuming that it would be roughly in parallel to the cellularity of the lesion in extra-abdominal desmoid fibromatosis and in other fibromatoses as well. There appeared to be no particular correlation between the number of myofibroblasts and recurrence of the lesion.

  2. The enigma of Serre's "Z-plasty" technique.

    Science.gov (United States)

    Borges, A F

    1985-09-01

    In 1835, Serre performed an operation to correct a cicatricial displacement of the right mouth commissure, which he described in his 1842 book. The drawings shown in a plate in the book (Fig. 2) and the description of the technique in the legend depicted the technique he had planned to perform (excision of tissue within lines ABCDE) but was not the technique he actually did. The description of the technique in the text of the book (Fig. 4) is very poor and incomplete. Apparently, he raised a triangular flap, which contained the right commissure, and sutured it into the skin defect on the check that he had created. The Z-plasty technique attributed to him (Fig. 1) in many textbooks is not the technique he had planned nor the technique he performed. He did not describe a Z-plasty but only the transposition of a single flap. PMID:3898170

  3. Neglect leads to extremes: maggots and malignancy in a case of discoid lupus erythematosus.

    Science.gov (United States)

    Bhari, N; Khaitan, B K; Gupta, P; Kumar, T; Srivastava, A

    2016-01-01

    Discoid lupus erythematosus (DLE) is a chronic form of cutaneous lupus erythematosus that runs an indolent course. The rare complications of DLE include scarring, mutilation, non-healing ulceration, cicatricial alopecia and malignancy. DLE progresses to systemic lupus erythematosus (SLE) in around 5% of localized cases and 22% of generalized cases. We report a case of DLE, presenting with a six-month history of ulcerated fungating plaques and small crusted nodules superimposed on DLE plaques over both the forearms. Two weeks prior to the presentation, maggots were also noticed on these plaques. Skin biopsies from these lesions were suggestive of squamous cell carcinoma (SCC) and keratoacanthoma. A wide surgical excision of the tumor followed by partial split-thickness skin grafting was performed with complete healing of the lesions. No recurrence has been noted 18 months from follow-up.

  4. Management of laryngotracheal stenosis in infants and children: the role of re-do surgery in cases of severe subglottic stenosis.

    Science.gov (United States)

    Maeda, Kosaku; Ono, Shigeru; Baba, Katsuhisa

    2013-10-01

    Although many advances have improved the treatment of congenital and acquired laryngotracheal stenosis in children over the past two decades, the therapeutic decision-making process remains challenging for pediatric surgeons and otolaryngologists. Severe subglottic stenosis is a complex laryngeal injury that necessitates multiple airway procedures, and the approach depends on the exact nature of the cicatricial lesion and its effect on the vocal cord mobility. Therefore, it is imperative that the pediatric surgeons and otolaryngologists dealing with this situation should be well trained in endoscopy and laser treatment, in addition to open surgical intervention. Open re-do surgery remains the best choice in cases of severe congenital stenosis, glottic immobility, or after two to three endoscopic procedures have been performed without any significant improvement.

  5. Líquido amniótico tópico: uma potencial nova alternativa para doenças da superfície ocular Topical amniotic fluid: a potential new alternative for ocular surface diseases

    OpenAIRE

    Guilherme Goulart Quinto; Suy Anne Rebouças Martins; Renata Tiemi; Mauro Campos; Ashley Behrens

    2008-01-01

    O líquido amniótico banha o feto durante a vida intra-uterina e está em contato permanente com a superfície ocular durante este importante período do desenvolvimento. Ele contém uma série de fatores de crescimento que podem ter diversos efeitos sobre o processo cicatricial. Estes fatores aceleram a recuperação da sensibilidade corneana e regeneração nervosa após procedimentos cerato-refrativos, além de controlar a formação de cicatriz e o equilíbrio da superfície ocular após sua aplicação tóp...

  6. Graham Little-Lassueur Syndrome with Hypertrophic Lichen Planus in a Patient with Chronic Hepatitis C

    Directory of Open Access Journals (Sweden)

    Badea Mihail Alexandru

    2016-03-01

    Full Text Available Graham Little-Lassueur Syndrome (GLLS is considered a form of lichen planopilaris which associates follicular lichen planus, cicatricial alopecia of the scalp and noncicatricial alopecia of the axillary and/or pubic regions. We present the case of a 47 years old female patient, known for 5 years with chronic hepatitis C and a poor therapeutic control of the disease due to Interferon intolerance. She presented to our clinic for the occurrence on the shins of some well-defined, intensely pruritic erythematous plaques, covered with thick scales, with a verrucous appearance, accompanied by excoriations. The skin biopsy reveal hypertrophic lichen planus on the shins and lichen planopilaris on the scalp. The patient was treated with systemic antihystamines, topical corticosteroids and salicylic acid under occlusion, emollients, phototherapy UVB narrow band 4 sessions/week for 3 weeks, cryotherapy. From our knowledge this is the first case of GLLS associated with chronic viral hepatis C.

  7. Perda pilosa por líquen plano pilar após transplante capilar: relato de dois casos e revisão da literatura Hair loss due to lichen planopilaris after hair transplantation: a report of two cases and a literature review

    Directory of Open Access Journals (Sweden)

    Márcio Rocha Crisóstomo

    2011-04-01

    Full Text Available Alopecia androgenética é tratada com frequência por meio de microtransplante capilar, téc nica em que os fios transplantados geralmente não caem, pois mantêm características da área doadora, mais resistente. O líquen plano pilar é uma alopecia cicatricial com permanente destruição pilosa. Este artigo relata dois casos de lesões compatíveis com líquen plano pilar em áreas receptora e doadora póstransplante. A dominância da área doadora foi aparentemente sobrepujada pelo líquen plano pilar, que deve ter gerado a queda dos fios. Relatos semelhantes são raros. À suspeita de líquen plano pilar, devese biopsiar o couro cabeludo e evitar o transplante durante a atividade da doença.Androgenetic alopecia is often treated by follicular unit transplantation, a technique that involves minimal risk of hair loss because of the more resistant nature of the donor area. Lichen planopilaris is a cicatricial alopecia that causes permanent destruction of hair follicles. We report two cases of post-transplantation lesions compatible with lichen planopilaris in both recipient and donor areas. The quality of the hair follicles in the donor area was apparently compromised by lichen planopilaris, the probable cause of hair loss. Similar reports are rare. When lichen planopilaris is suspected, a biopsy of the scalp must be performed to avoid transplantation during disease activity.

  8. Graham-Little Piccardi Lassueur Syndrome: case report Síndrome de Graham-Little Piccardi Lassueur: relato de caso

    Directory of Open Access Journals (Sweden)

    Raquel Bissacotti Steglich

    2012-10-01

    Full Text Available A 33-year-old woman presented with a 3-year history of progressive alopecia of the scalp. Past treatment with hydroxicloroquine did not show improvement. Physical examination revealed multiple areas of alopecia with atrophic aspect of the scalp, and axillary and pubic hypotrichosis. Dermoscopy showed hyperkeratosis and accentuation of follicular ostia. Anatomopathological examination revealed decrease in the number of hair follicles, upper perifollicular infiltrate and areas with fibrosis. The Piccardi-Lassueur-Graham-Little syndrome is a rare disorder, characterized by the triad of multifocal scarring alopecia of the scalp, keratotic follicular eruption and hypotrichosis of axillary and pubic regions. Management is a challenge and many medications tried have controversial results. We report a case of this rare syndrome which improved with corticoids.Mulher, 33 anos, apresenta quadro de alopecia progressiva do couro cabeludo há 3 anos. Tratamento com hidroxicloroquina há 12 meses, sem apresentar melhora. Ao exame físico exibe múltiplas áreas de alopecia cicatricial no couro cabeludo, além de hipotricose axilar e pubiana. A dermatoscopia evidencia hipercetose folicular e acentuação dos óstios foliculares. O exame anatomopatológico revela diminuição do número de folículos pilosos, infiltrado perifolicular e fibrose. A síndrome de Graham-Little Piccardi Lassueur é uma dermatose rara, caracterizada pela tríade de alopecia cicatricial multifocal do couro cabeludo, ceratose folicular disseminada e hipotricose das regiões axilares e pubianas. A terapêutica desta dermatose é um desafio, muitas medicações relatadas tem resultados controversos. Relatamos o caso desta síndrome rara que apresentou melhora com corticoterapia.

  9. Hair follicle stem cells in disorders characterized by alopecia%毛囊干细胞在脱发性疾病中的研究进展

    Institute of Scientific and Technical Information of China (English)

    管海宏; 李泓馨; 林麟

    2012-01-01

    Alopecia,as a common disease,is generally classified into two groups,cicatricial and noncicatricial alopecia,according to clinical presentations and regrowth capability of hairs,and each group includes various types of alopecia.The pathogenesis of alopecia remains poorly understood.Hair follicle stem cells are located in the bulge area,whose periodic proliferation and differentiation sustain the growth,shedding and regrowth of hairs.Recent research has indicated that the damage or deficiency of hair follicle stem cells may contribute to the pathogenesis of some types of alopecia,especially cicatricial alopecia.%脱发性疾病在临床比较常见,一般按临床表现和毛发是否可再生而将脱发分为瘢痕性脱发和非瘢痕性脱发,每种均包含了多种不同的脱发性疾病.目前脱发性疾病的发病机制仍不甚清楚.毛囊干细胞位于毛囊隆突区,其周期性地增殖和分化维持了毛发的正常生长、脱落与更替.研究表明,毛囊干细胞的损伤或缺失很可能参与了某些脱发性疾病尤其是瘢痕性脱发的发病过程.

  10. [Chromoblastomycosis caused by Fonsecaea monophora].

    Science.gov (United States)

    Sugiyama, Yuka; Suzuki, Yoko; Sugaya, Keiko; Tokura, Yoshiki; Yaguchi, Takashi; Kamei, Katsuhiko; Nishimura, Kazuko

    2011-01-01

    Fonsecaea species are major etiologic agents of Chromoblastomycosis (CBM). By genetic analysis, the genus Fonsecaea has recently been revised and classified into F. pedorosoi, F. monophora and F. nubica. Here we report a severe chronic case of CBM caused by F. monophora. A 55-year-old Filipino male developed progressive skin lesions on the left lateral ankle in 1973, when he worked at a coconut plantation in the Philippines. In 1999, he received medical treatments for enlarged, multiple lesions on the left lower limb. When he moved to Japan in 2005, the lesions were remarkably improved and he discontinued taking the medicine. On our first examination in October 2008, a large, reddish, cicatricial plaque was observed on the left lower aspect of his leg. Several tumorous lesions surrounded the plaque, indicating that the therapies performed before had been insufficient. In addition, there were many patchy scars scattered on the thigh and the upper part of the lower leg. The diagnosis of CBM was made by the presence of muriform cells. Black, pulverulent colonies were yielded in culture of skin scrapings and tissues. Although the fungus could not be identified by microscopic morphology, r-RNA ITS sequence analysis enabled identification of Fonsecaea monophora. The patient responded well to oral voriconazole combined with local thermotherapy using pocket warmers. The tumoral masses subsided in 6 months, leaving pink scars with negative fungal culture. Voriconazole treatment was continued for 18 months. It seems that drugs are insufficiently delivered in the cicatricial lesions because of the paucity of blood flow, suggesting that a long-term follow-up is necessary for such a case. PMID:21891988

  11. Effects of Carbon Nanotube Environmental Dispersion on an Aquatic Invertebrate, Hirudo medicinalis.

    Science.gov (United States)

    Girardello, Rossana; Tasselli, Stefano; Baranzini, Nicolò; Valvassori, Roberto; de Eguileor, Magda; Grimaldi, Annalisa

    2015-01-01

    The recent widespread applications of nanomaterials, because of their properties, opens new scenarios that affect their dispersal in the environment. In particular multiwall carbon nanotubes (MWCNTs), despite their qualities, seem to be harmful for animals and humans. To evaluate possible toxic effects caused by carbon nanotube environmental dispersion, with regard to aquatic compartment, we proposed as experimental model a freshwater invertebrate: Hirudo medicinalis. In the present study we analyse acute and chronic immune responses over a short (1, 3, 6 and 12 hours) and long time (from 1 to 5 weeks) exposure to MWCNTs by optical, electron and immunohistochemical approaches. In the exposed leeches angiogenesis and fibroplasia accompanied by massive cellular migration occur. Immunocytochemical characterization using specific markers shows that in these inflammatory processes the monocyte-macrophages (CD45+, CD68+) are the most involved cells. These immunocompetent cells are characterized by sequence of events starting from the expression of pro-inflammatory cytokines (in particular IL-18), and amyloidogenensis. Our combined experimental approaches, basing on high sensitive inflammatory response can highlight adverse effects of nanomaterials on aquatic organisms and could be useful to assess the MWCNTs impact on aquatic, terrestrial animal and human health. PMID:26636582

  12. Effects of Carbon Nanotube Environmental Dispersion on an Aquatic Invertebrate, Hirudo medicinalis.

    Directory of Open Access Journals (Sweden)

    Rossana Girardello

    Full Text Available The recent widespread applications of nanomaterials, because of their properties, opens new scenarios that affect their dispersal in the environment. In particular multiwall carbon nanotubes (MWCNTs, despite their qualities, seem to be harmful for animals and humans. To evaluate possible toxic effects caused by carbon nanotube environmental dispersion, with regard to aquatic compartment, we proposed as experimental model a freshwater invertebrate: Hirudo medicinalis. In the present study we analyse acute and chronic immune responses over a short (1, 3, 6 and 12 hours and long time (from 1 to 5 weeks exposure to MWCNTs by optical, electron and immunohistochemical approaches. In the exposed leeches angiogenesis and fibroplasia accompanied by massive cellular migration occur. Immunocytochemical characterization using specific markers shows that in these inflammatory processes the monocyte-macrophages (CD45+, CD68+ are the most involved cells. These immunocompetent cells are characterized by sequence of events starting from the expression of pro-inflammatory cytokines (in particular IL-18, and amyloidogenensis. Our combined experimental approaches, basing on high sensitive inflammatory response can highlight adverse effects of nanomaterials on aquatic organisms and could be useful to assess the MWCNTs impact on aquatic, terrestrial animal and human health.

  13. Diagnostic and clinical observation on the infectious bronchitis virus strain Q1 in Italy

    Directory of Open Access Journals (Sweden)

    Anna Toffan

    2013-12-01

    Full Text Available This paper describes the diagnostic and clinical observations of an infectious bronchitis virus (IBV variant, referred to as Q1, in clinically ill chickens in Italy. This IBV variant was described for the first time in 1998 in China. In the autumn of 2011 it caused a small-scale epidemic in non-vaccinated meat chickens in farms located in Northern Italy. The disease was characterized by increased mortality, kidney lesions and proventriculitis. Histopatological observations confirmed the nephritis and described an unusual erosive/necrotic proventriculitis with infiltration of lymphocytes, plasma cells and heterophils, as well as fibroplasia in the lamina propria. Despite these findings and the isolation of the Q1 IB virus directly from proventricular tissue, further studies are necessary to confirm the role of this IBV strain in the development of proventricular lesions. Phylogenetic analysis revealed that all the IBV isolates were very similar and probably had a common origin. The IBV Q1 variant appears to be now endemic in the North of Italy and at times it is detected in vaccinated backyard and commercial broiler farms. The importance of continuous monitoring in controlling the spread of known or emerging IBV variants is underlined.

  14. CD4(+)CD25(hi)Foxp3(+) Cells Exacerbate Bleomycin-Induced Pulmonary Fibrosis.

    Science.gov (United States)

    Birjandi, Shirin Z; Palchevskiy, Vyacheslav; Xue, Ying Ying; Nunez, Stefanie; Kern, Rita; Weigt, S Sam; Lynch, Joseph P; Chatila, Talal A; Belperio, John A

    2016-08-01

    Idiopathic pulmonary fibrosis is a fatal lung disease with a median survival of 2 to 5 years. A decade of studies has downplayed inflammation contributing to its pathogenesis. However, these studies preceded the discovery of regulatory T cells (Tregs) and all of their functions. On the basis of human studies demonstrating Tregs can decrease graft-versus-host disease and vasculitides, there is consideration of their use to treat idiopathic pulmonary fibrosis. We hypothesized that Treg therapy would attenuate the fibroplasia involved in a preclinical murine model of pulmonary fibrosis. IL-2 complex was used in vivo to expand CD4(+)CD25(hi)Foxp3(+) cells in the lung during intratracheal bleomycin challenge; however, this unexpectedly led to an increase in lung fibrosis. More important, this increase in fibrosis was a lymphocyte-dependent process. We corroborated these results using a CD4(+)CD25(hi)Foxp3(+) cellular-based therapy. Mechanistically, we demonstrated that CD4(+)CD25(hi)Foxp3(+) cells undergo alterations during bleomycin challenge and the IL-2 complex had no effect on profibrotic (eg, transforming growth factor-β) or type 17 immune response cytokines; however, there was a marked down-regulation of the type 1 and augmentation of the type 2 immune response cytokines from the lungs. Collectively, our animal studies show that a specific lung injury can induce Treg alterations, which can augment pulmonary fibrosis. PMID:27317904

  15. Relationship of creatine kinase, aspartate aminotransferase, lactate dehydrogenase, and proteinuria to cardiomyopathy in the owl monkey (Aotus vociferans)

    Energy Technology Data Exchange (ETDEWEB)

    Gozalo, Alfonso S.; Chavera, Alfonso; Montoya, Enrique J.; Takano, Juan; Weller, Richard E.

    2008-02-01

    The purpose of this study was to determine serum reference values for crea- tine kinase (CK), aspartate aminotransferase (AST), and lactate dehydroge- nase (LDH) in captive-born and wild-caught owl monkeys to assess their usefulness for diagnosing myocardial disease. Urine samples were also collected and semi-quantitative tests performed. There was no statistically significant difference between CK, AST, and LDH when comparing both groups. However, when comparing monkeys with proteinuria to those without proteinuria, a statistically significant difference in CK value was observed (P = 0.021). In addition, the CK/AST ratio revealed that 29% of the animals included in this study had values suggesting cardiac infarction. Grossly, cardiac concentric hypertrophy of the left ventricle and small, pitted kidneys were the most common findings. Microscopically, myocardial fibrosis, contraction band necrosis, hypertrophy and hyperplasia of coronary arteries, medium-sized renal arteries, and afferent glomerular arteriolae were the most significant lesions, along with increased mesangial matrix and hypercellularity of glomeruli, Bowman’s capsule, and peritubular space fibroplasia. These findings suggest that CK, AST, and LDH along with urinalysis provide a reliable method for diagnosing cardiomyopathies in the owl monkey. In addition, CK/AST ratio, proteinuria, and the observed histological and ultrastructural changes suggest that Aotus vociferans suffer from arterial hypertension and chronic myocardial infarction.

  16. Ultrastructure of oval cells in children with chronic hepatitis B, with special emphasis on the stage of liver fibrosis: The first pediatric study

    Institute of Scientific and Technical Information of China (English)

    Maria Elzbieta Sobaniec-Lotowska; Joanna Maria Lotowska; Dariusz Marek Lebensztejn

    2007-01-01

    AIM: To investigate the ultrastructure of oval ceils in children with chronic hepatitis B, with special emphasis on their location in areas of collagen fibroplasia.METHODS: Morphological investigations were conducted on biopsy material obtained from 40 children,aged 3-16 years with chronic hepatitis B. The stage of fibrosis was assessed histologically using the arbitrary semiquantitative numerical scoring system proposed by Ishak et al. The material for ultrastructural investigation was fixed in glutaraldehyde and paraformaldehyde and processed for transmission-electron microscopic analysis.RESULTS: Ultrastructural examination of biopsy specimens obtained from children with chronic hepatitis B showed the presence of two types of oval cells, the hepatic progenitor cells and intermediate hepatic-like cells. These cells were present in the parenchyma and were seen most commonly in areas of intense periportal fibrosis (at least stage 2 according to Ishak et al) and in the vicinity of the limiting plate of the lobule. The activated nonparenchymal hepatic cells, i.e. transformed hepatic stellate cells and Kupffer cells were seen in close proximity to the intermediate hepatic-like cells.CONCLUSION: We found a distinct relationship between the prevalence of oval cells (hepatic progenitor cells and intermediate hepatocyte-like cells) and fibrosis stage in pediatric patients with chronic hepatitis B.

  17. Bubaline Cholecyst Derived Extracellular Matrix for Reconstruction of Full Thickness Skin Wounds in Rats

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    Poonam Shakya

    2016-01-01

    Full Text Available An acellular cholecyst derived extracellular matrix (b-CEM of bubaline origin was prepared using anionic biological detergent. Healing potential of b-CEM was compared with commercially available collagen sheet (b-CS and open wound (C in full thickness skin wounds in rats. Thirty-six clinically healthy adult Sprague Dawley rats of either sex were randomly divided into three equal groups. Under general anesthesia, a full thickness skin wound (20 × 20 mm2 was created on the dorsum of each rat. The defect in group I was kept as open wound and was taken as control. In group II, the defect was repaired with commercially available collagen sheet (b-CS. In group III, the defect was repaired with cholecyst derived extracellular matrix of bovine origin (b-CEM. Planimetry, wound contracture, and immunological and histological observations were carried out to evaluate healing process. Significantly (P<0.05 increased wound contraction was observed in b-CEM (III as compared to control (I and b-CS (II on day 21. Histologically, improved epithelization, neovascularization, fibroplasia, and best arranged collagen fibers were observed in b-CEM (III as early as on postimplantation day 21. These findings indicate that b-CEM have potential for biomedical applications for full thickness skin wound repair in rats.

  18. Acral-lentiginous naevus of plantar skin.

    Science.gov (United States)

    Clemente, C; Zurrida, S; Bartoli, C; Bono, A; Collini, P; Rilke, F

    1995-12-01

    In a consecutive series of 165 plantar naevi, a group of 36 benign naevi with sufficiently distinctive histopathological features to justify their classification as a special entity, here designated acral-lentiginous naevus, was identified. The main morphological features distinguishing the acral-lentiginous naevi from other acral non-lentiginous naevi are: elongation of rete ridges, continuous proliferation of melanocytes at the dermo-epidermal junction, presence of single scattered melanocytes, or less commonly small clusters, within the upper epidermis, poor or absent lateral circumscription, melanocytes with abundant pale cytoplasm and round to oval, sometimes hyperchromatic, nuclei and prominent nucleoli present at the dermo-epidermal junction. Some histological features of acral-lentiginous naevi are similar to those of dysplastic naevi: however, anastomosing rete ridges, cytological atypia and well-formed lamellar fibroplasia are absent. The histopathological criteria to distinguish these naevi from melanoma are: the lack of pagetoid lateral spread, the absence of mitotic activity in the deep dermal component and the evidence of dermal naevocytic differentiation. The identification of this benign acral naevus, that we have identified as the benign counterpart of acral lentiginous melanoma, is important in order to avoid misdiagnoses and consequent under- or over-treatment of doubtful pigmented lesions of acral skin.

  19. The effects of topical oxygen therapy on equine distal limb dermal wound healing.

    Science.gov (United States)

    Tracey, Alexandra K; Alcott, Cody J; Schleining, Jennifer A; Safayi, Sina; Zaback, Peter C; Hostetter, Jesse M; Reinertson, Eric L

    2014-12-01

    Topical oxygen therapy (TOT) has been used in human medicine to promote healing in chronic wounds. To test the efficacy and safety of TOT in horses, an experimental wound model was created by making 1 standardized dermal wound on each limb of 4 healthy horses (n = 16). Each wound was fitted with an oxygen delivery cannula and covered with a bandage. One limb of each front and hind pair was randomly assigned to the treatment group (fitted with an oxygen concentrator device), with the contralateral limb assigned to the control group (no device). Wound area, epithelial area, and contraction were measured every 3 to 4 d. Biopsy samples and culture swabs were taken on days 16 and 32 to evaluate angiogenesis, fibroplasia, epithelial hyperplasia, inflammation and bacterial growth. Mean healing time in treated wounds (45 d, range: 38 to 52 d) was not significantly different from that in the paired control wounds (50 d, range: 38 to 62 d). Topical oxygen therapy had little effect on dermal wound healing in this experimental wound model in healthy horses.

  20. Avocado/soybean unsaponifiables: a novel regulator of cutaneous wound healing, modelling and remodelling.

    Science.gov (United States)

    Oryan, Ahmad; Mohammadalipour, Adel; Moshiri, Ali; Tabandeh, Mohammad R

    2015-12-01

    We investigated the effects of avocado/soybean unsaponifiables (ASU) on the healing response of cutaneous wound defect in rats. Sixty male rats were randomly divided into three groups including control, vehicle and treatment (n = 20 in each group). A 2 × 2 cm(2) wound defect was made on the dorsum. The control, vehicle and treatment groups were treated daily with topical application of saline, cream and cream/ASU for 10 days, respectively. The wounds were monitored daily. The animals were euthanised at 10, 20 and 30 days post injury (D). The dry matter, hydroxyproline, collagen, n-acetyl glucosamine (NAGLA) and n-acetyl galactosamine (NAGAA) contents of the skin samples were measured and the histopathological and biomechanical characteristics of the samples were investigated. Statistics of P < 0·05 was considered significant. Treatment significantly increased tissue glycosaminoglycans and collagen contents at various stages of wound healing compared to controls. Treatment modulated inflammation, improved fibroplasia and produced high amounts of scar tissue at short term. At long term, treatment reduced the scar tissue size and increased the quality and rate of wound contraction and reepithelisation compared to controls. The treated lesions were more cosmetically pleasing and had significantly higher biomechanical characteristics than controls. ASU was effective in rat wound healing. PMID:24321012

  1. Human umbilical mesenchymal stem cells conditioned medium promote primary wound healing regeneration

    Directory of Open Access Journals (Sweden)

    Dwi Liliek Kusindarta

    2016-06-01

    Full Text Available Aim: This research was conducted to clarify the capability of human umbilical mesenchymal stem cells conditioned medium (HU-MSCM to promote regenerations of primary wound healing on the incision skin injury. Materials and Methods: In this study, two approaches in vitro and in vivo already done. On in vitro analysis, tube formation was performed using HU vein endothelial cells in the presence of HU-MSCM, in some experiments cells line was incubated prior the presence of lipopolysaccharide and HU-MSCM then apoptosis assay was performed. Furthermore, in vivo experiments 12 female rats (Rattus norvegicus were used after rats anesthetized, 7 mm wound was made by incision on the left side of the body. The wound was treated with HU-MSCM containing cream, povidone iodine was run as a control. Wound healing regenerations on the skin samples were visualized by hematoxylin-eosin staining. Results: In vitro models elucidate HU-MSCM may decreasing inflammation at the beginning of wound healing, promote cell migration and angiogenesis. In addition in vivo models show that the incision length on the skin is decreasing and more smaller, HE staining describe decreasing of inflammation phase, increasing of angiogenesis, accelerate fibroplasia, and maturation phase. Conclusions: Taken together our observation indicates that HU-MSCM could promote the acceleration of skin tissue regenerations in primary wound healing process.

  2. A influência da calcitonina sintética de salmão na cicatrização cutânea de ratos Influence of the synthetic salmon calcitonin in cutaneous wound healing of the rats

    Directory of Open Access Journals (Sweden)

    José Neiva Eulálio

    2007-08-01

    Full Text Available OBJETIVO: O presente trabalho tem como objetivo investigar a influência da calcitonina sintética do salmão no processo cicatricial da pele da região dorsal em ratos, analisando parâmetros bioquímicos, biomecânicos e histológicos, e suas possíveis interrelações. MÉTODO: Setenta e dois (72 ratos machos adultos foram submetidos, sob anestesia geral inalatória a uma incisão linear na pele que foi, subseqüentemente, suturada. Metade dos ratos (grupo teste foi tratada no pós-operatório com calcitonina sintética do salmão, e a outra metade, sem tratamento, constituiu o grupo controle. Os animais, em pares de nove ratos cada (teste e controle, foram sacrificados no 5º, 10º, 15º e 20º dias pós-operatório para a remoção dos fragmentos de pele com cicatriz para as análises bioquímicas, biomecânicas e histológicas. Utilizou-se o teste "t" de Student para a comparação de médias de amostras independentes e o teste de correlação de Pearson para verificar o grau de associação entre as médias das variáveis. RESULTADOS: A calcitonina sintética de salmão acelerou o processo cicatricial da pele, mas não de maneira linear e constante. Em comparação com os animais não-tratados, houve aumento significativo tanto do conteúdo de hidroxiprolina nas fases de proliferação inicial e tardia da cicatrização, quanto da carga máxima de ruptura na fase de proliferação tardia. Os resultados histológicos corroboram os resultados bioquímicos e biomecânicos, sugerindo uma correlação entre conteúdo de colágeno, resistência à tração e histologia da cicatriz. CONCLUSÃO: A calcitonina sintética de salmão acelerou o processo cicatricial da pele, modificando significativamente o conteúdo de colágeno e a carga máxima de ruptura, mas não de maneira linear e constante.BACKGROUND: The aim of the present study was to investigate the influence of synthetic salmon calcitonin on wound healing in dorsal skin of rats

  3. Effects of preoperative pelvic irradiation on colonic anastomosis healing: an experimental study in rats Efeito da radioterapia pélvica pré-operatória na cicatrização de anastomoses colônicas: estudo experimental em ratos

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    Alexandre Franca

    2008-01-01

    Full Text Available PURPOSE: Colorectal anastomosis is a constant worry-issue among surgeons because of high rates of complications, specially the dehiscence. The preoperative irradiation on cancer surgeries might interfere in the healing process, leading to an unfavorable outcome. METHODS: In the present study, two groups of rats were irradiated previously to a colorectal anastomosis surgery, with intervals of 4 and 8 weeks between the procedures. Seven days after the surgery, healing process was evaluated for dehiscence presence and histologic inflammatory characteristics. Also, levels of hydroxyproline, metalloproteinases and vascular endothelial growth factor were measured. RESULTS: Our results showed a higher incidence of dehiscences on the animals submitted to irradiation, compared to controls, with a reduced inflammatory activity in the healing tissue. DISCUSSION: Comparing both irradiated groups, those irradiated 8 weeks before surgery showed higher levels of hydroxyproline and metalloproteinases, indicating higher efficiency of the healing process. In conclusion, preoperative irradiation interferes with intestinal anastomosis healing and a larger time interval between both procedures is safer in terms of the healing quality.INTRODUÇÃO: As anastomoses colorretais são motivos constante de preocupação por parte dos cirurgiões, em virtude do alto índice de complicações, principalmente as deiscências. O uso da radioterapia previamente à cirurgia, nos casos de doença neoplásica, pode interferir no processo cicatricial das anastomoses, e levar a uma evolução desfavorável. MÉTODOS: Os autores estudaram dois grupos de ratos, submetidos a radioterapia e à confecção de uma anastomose no cólon, com intervalo de 04 e de 08 semanas entre os dois procedimentos, comparando com um grupo controle. Após 07 dias da cirurgia, estudaram-se vários aspectos do processo cicatricial: presença de deiscência, características inflamatórias do tecido, dosagem

  4. Estudo histológico comparativo de implantes (ímãs em órbitas de coelhas Comparative histologic study of implants (magnets in orbits of female rabbits

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    Elcio Roque Kleinpaul

    2005-10-01

    Full Text Available OBJETIVOS: Avaliação microscópica dos sinais da reação inflamatória causada pela fixação de implante orbitário (ímã, recoberto por ouro. MÉTODOS: Estudo experimental em 54 coelhas adultas, divididas em três grupos de 18, com 3 subgrupos de 6, avaliação com uma, três e seis semanas de pós-operatório. Fixação, no rebordo inferior da órbita, de implante (ímã e ouro por meio de cola, parafuso ou fio inabsorvível (Mersilene 5.0®. As órbitas contralaterais (sem implante compuseram o grupo-controle. RESULTADOS: Sinais histológicos de reação inflamatória à fixação orbitária do implante foram observados, com cianoacrilato, parafuso, ou sutura inabsorvível (Mersilene 5.0®, até a sexta semana pós-operatória, com predomínio do processo inflamatório crônico e fibrótico cicatricial, sem demonstrar diferenças estatisticamente significativas na maior parte dos casos. CONCLUSÃO: O exame histopatológico demonstrou, na maior parte das órbitas com e sem implante, presença de reação inflamatória aguda e crônica até a sexta semana pós-operatória, com predomínio de processo inflamatório crônico e fibrótico cicatricial, sem demonstrar, na maior parte dos casos, diferenças estatisticamente significante entre os grupos experimental e controle.PURPOSE: To evaluate microscopically the signs of inflammatory reaction due to the fixation of an orbitary implant (magnet, covered by gold. METHODS: An experimental study was performed in 54 adult female rabbits, divided into 3 groups of eighteen with 3 subgroups of 6; an evaluation at 1, 3 and 6 postoperative weeks was performed. An implant (magnet, covered by gold was fixed in the inferior orbital rim using biologic glue, screw or unabsorbable suture (Mersilene 5.0®. The opposite orbits (without implants represented the control group. RESULTS: Microscopic signs of inflammatory reaction due to orbitary fixation of the implant were observed with the use of the three

  5. Vigilância epidemiológica do tracoma em instituição de ensino na cidade de São Paulo, SP Epidemiological surveillance of trachoma in a school in an urban area in Southeastern Brazil

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    Norma H. Medina

    1998-02-01

    Full Text Available OBJETIVO: Verificar as condições de vigilância epidemiológica do tracoma desencadeadas a partir da detecção de um caso de tracoma inflamatório na APAE - SP. MATERIAL E MÉTODO: Foram submetidos a exame ocular 1.009 pessoas entre alunos, funcionários e comunicantes intradomiciliares. Os controles de tratamento foram realizados em uma instituição, por 4 vezes, em intervalos de 45 dias. RESULTADOS: A prevalência total foi de 5,9%, sendo 5,1% de tracoma folicular (TF, 0,3% de tracoma folicular intenso (TF/TI e 0,5% de tracoma cicatricial (TS. No primeiro controle 45,5% dos casos apresentou alta clínica e 40,0% manteve tratamento. No último controle 20,0% apresentou alta curado sem cicatrizes. A taxa de faltosos alcançou 38,2%. A distribuição espacial dos casos secundários mostrou ampla dispersão na Grande São Paulo, indicando que o tracoma deve estar disseminado por toda a região. DISCUSSÃO/CONCLUSÕES: As ações de controle do tracoma não apresentaram resultados satisfatórios, provavelmente devido ao prolongado tempo de tratamento e acompanhamento. Estratégias de intervenção clínica devem ser desenvolvidas para melhor controle da doença.INTRODUCTION: Epidemiological surveillance activities undertaken after the detection of an active trachoma case in the APAE-SP are described. MATERIAL AND METHOD: A total of 1,009 pupils, employees and household contacts had an eye examination. Treatment control was carried out at the institution 4 times at 45 day-intervals. RESULTS: The overall prevalence was of 5.9%, 5.1% being of follicular trachoma (TF, 0.3% of intense trachoma (TF/TI and 0.5% of cicatricial trachoma (TS. At the first control exercise 45.5% of the trachoma cases had no signs of the disease and 40.0% underwent treatment. At the last control exercise 20% were found to have been cured with no vestigial scars. Non-attendance was of 38.2%. The distribution of secondary cases showed great dispersion, suggesting

  6. Control of the skin scarring response

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    Lydia M. Ferreira

    2009-09-01

    Full Text Available There comes a time when the understanding of the cutaneous healing process becomes essential due to the need for a precocious tissue repair to reduce the physical, social, and psychological morbidity. Advances in the knowledge on the control of interaction among cells, matrix and growth factors will provide more information on the Regenerative Medicine, an emerging area of research in medical bioengineering. However, considering the dynamism and complexity of the cutaneous healing response, it is fundamental to understand the control mechanism exerted by the interaction and synergism of both systems, cutaneous nervous and central nervous, via hypothalamus hypophysis-adrenal axis, a relevant subject, but hardly ever explored. The present study reviews the neuro-immune-endocrine physiology of the skin responsible for its multiple functions and the extreme disturbances of the healing process, like the excess and deficiency of the extracellular matrix deposition.Aproxima-se uma época na qual é fundamental a compreensão do processo cicatricial cutâneo frente à necessidade da restauração tecidual precoce, visando a diminuição das morbidades física, social e psicológica. O avanço no conhecimento acerca do controle das interações entre as células, a matriz e os fatores de crescimento dará maiores informações à Medicina Regenerativa, área de pesquisa emergente da bioengenharia médica. Entretanto, diante do dinamismo e complexidade da resposta cicatricial cutânea torna-se indispensável o entendimento do mecanismo de controle exercido pela interação e sinergismo do sistema nervoso cutâneo e o sistema nervoso central, via eixo hipotálamo-hipófise-adrenal, tema relevante, porém, pouco abordado. O presente estudo revisa a fisiologia neuro-imuno-endócrina da pele, responsável por suas múltiplas funções, e os distúrbios extremos do processocicatricial, como o excesso e deficiência de deposição da matriz extracelular.

  7. 枸杞多糖对小鼠移植性肝癌抑制作用的实验研究%Inhibition of Lycium barbarum polysaccharide on transplanted liver cancer in mice

    Institute of Scientific and Technical Information of China (English)

    张鸣号; 王秀玉; 王秀梅; 刘青; 杨美玲

    2012-01-01

    Objective To explore the inhibition of Lycium barbarum polysaccharide (LBP) on transplanted liver cancer in mice. Methods The transplanted liver cancer model was established with hypodermic inoculation. Ninety-six mice were randomly divided into six groups: control group, model group, LBP high-, middle-, and low-dose (20, 10, and 5 mg/kg) groups, and cyclophosphamide (20 mg/kg) group. The effects of LBP on mortality, gross tumor volume, inhibitory rate of tumor growth, tumorous cellular density, karyokinesis, degree of tumor necrosis, lymphocyte infiltration, and fibroplasia in interstitial substance in tumor-bearing mice were observed. Results LBP with high, middle, and low doses could obviously depress the death rate of tumor-bearing mice (P < 0.05) and diminish gross tumor volume and weight (P < 0.05). The inhibitory rates of tumor growth were 42.23%, 25.10%, and 9.16%. LBP with high and middle doses could degrade the tumorous cellular density (P < 0.05), decrease the karyokinesis (P < 0.05), and increase the degree of tumor necrosis, lymphocyte infiltration, and fibroplasia in interstitial substance in mice (P < 0.05). Conclusion LBP could produce the inhibition on transplanted liver cancer in mice.%目的 探讨枸杞多糖对小鼠移植性肝癌的抑制作用.方法 采用皮下接种法制备小鼠移植性肝癌(H22肝癌细胞株)模型,随机将96只小鼠分成对照组、模型组、枸杞多糖高、中、低剂量(20、10、5 mg/kg)组、环磷酰胺(20 mg/kg)组.观察枸杞多糖对荷瘤小鼠死亡率、肿瘤体积、肿瘤质量及肿瘤细胞密度、核分裂像、肿瘤坏死程度及间质淋巴细胞浸润、纤维组织增生情况的影响.结果 20、10、5 mg/kg的枸杞多糖能明显降低移植性肝癌小鼠的死亡率(P<0.05),减小肿瘤细胞的体积和质量(P<0.05),抑瘤率分别为42.23%、25.10%和9.16%;同时20、10 mg/kg的枸杞多糖能不同程度地降低肿瘤细胞密度(P<0.05),减少肿瘤

  8. Wound healing in the jugal mucosa of rats with a cold blade scalpel and an ultrasonic harmonic scalpel Cicatrização de feridas realizadas na mucosa jugal de ratos com bisturi com lâmina fria e com bisturi harmônico ultrassônico

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    Elen Carolina David João De Masi

    2009-06-01

    Full Text Available Ultrasound harmonic scalpel has been recently introduced in otorhinolaryngological procedures. AIM: to assess macro and microscopic evolution of the healing process of wounds created in the jugal mucosa of rats by the use of ultrasound scalpel. METHOD: we used 30 Wistar rats in which we made mucosal incisions on the right jugal mucosa with the ultrasound harmonic scalpel (USHS and on the left side with the cold blade scalpel (CBS. Macroscopic and microscopic evaluations were carried out on the third, seventh and fourteenth days of postoperative. For the microscopic evaluation we used HE to asses the inflammatory process and the Sirius Red approach for collagens type I and III. Anti-CD 3 antibodies and anti-factor VIII assessed the concentration of T-lymphocytes and neovessels. RESULTS: the USHS caused greater cell damage with reepitelization delay. Microscopy showed more intense inflammatory reactions and a loss in collagen build up, delay in scar maturation and a greater vessel neoformation. CONCLUSION: USHS brings about a greater lesion in the incision area; delayed regeneration; promotes greater inflammatory process and angiogenic activity; delays in fibroplasia and scar tissue maturation on the rats' jugal mucosa when compared to cold blade scalpel.O bisturi harmônico ultrassônico foi introduzido recentemente em operações otorrinolaringológicas. ObJETIVO: Avaliar a evolução macro e microscópica do processo de cicatrização de feridas realizadas na mucosa jugal de ratas com uso de bisturi ultrassônico. MÉTODO: Foram utilizadas 30 ratas Wistar com incisões na mucosa, no lado direito com bisturi harmônico ultrassônico (BHU e à esquerda com bisturi com lâmina fria (BLF. As avaliações macroscópicas e microscópicas foram realizadas no terceiro, sétimo e décimo quarto dias pós-operatório. Na análise microscópica utilizou-se coloração HE para avaliar o processo inflamatório e a técnica de Sirius red para os colágenos I

  9. Pengaruh Cairan Cultur Filtrate Fibroblast (CFF Terhadap Penyembuhan Luka; Penelitian eksperimental pada Rattus Norvegicus Galur Wistar

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    Oky Masir

    2012-11-01

    Full Text Available AbstrakLatar belakang:Metode penyembuhan luka telah mengalami perkembangan, baik berupa suatu produk atau stimulan terhadap proses biologis tubuh dalam menkompensasi luka. Fibroblas merupakan salah satu komponen penyembuhan yang berperan penting dalam proses fibroplasia. Culture Filtrate Fibroblast (CFF merupakan hasil kultur fibroblas yang akan dibuktikan efeknya terhadap proses percepatan penyembuhan luka pada penelitian ini. Metode. Penelitian ini menggunakan desain eksperimental dengan metode post test only control group design dan rancangan acak kelompok (RAK dengan menggunakan tikus putih wistar. Hewan coba dibagi menjadi 4 kelompok, yaitu 2 kelompok perlakuan yang diberikan CFF ke area eksisi luka dan kelompok kontrol yang diberikan larutan NaCl 0,9% ke area eksisi luka. Data diolah dengan SPSS 16.0. Data Kategori dianalisa dengan Chi-squared dan data numerik dengan Independent T-test. Hasil. Dari tingkat penyembuhan tidak ditemukan perbedaan pada kedua kelompok, namun perubahan restriksi jaringan lebih besar pada kelompok perlakuan. Pada skor pembentukan kolagen, derajat epitelisasi serta jumlah pembentukan pembuluh darah baru pada hari ke-3 tidak ditemukan perbedaan antara kedua kelompok. Namun pada pengamatan hari ke-7 memperlihatkan pembentukan kolagen, derajat epitelisasi serta jumlah pembentukan pembuluh darah baru lebih banyak pada kelompok perlakuan. Pada fibrosis hari ke-3 dan hari ke-7 memperlihatkan terjadinya fibrosis lebih banyak pada kelompok perlakuan dibanding kontrol. Pada pengamatan terjadinya infeksi hari ke-3 memperlihatkan infeksi lebih sedikit pada kelompok perlakuan dan terjadinya infeksi sama pada hari ke-7. Kesimpulan. CFF memberikan tingkat penyembuhan luka yang lebih baik dibanding NaCl.Kata kunci: CFF, NaCl 0,9 %, tingkat penyembuhan luka.Abstract Background: Wound healing methods have been developed, either a product or a stimulant to the body's biological processes in wound compensation. Fibroblasts is one

  10. Pulmonary toxicity of carbon nanotubes and asbestos - similarities and differences.

    Science.gov (United States)

    Donaldson, Ken; Poland, Craig A; Murphy, Fiona A; MacFarlane, Marion; Chernova, Tatyana; Schinwald, Anja

    2013-12-01

    Carbon nanotubes are a valuable industrial product but there is potential for human pulmonary exposure during production and their fibrous shape raises the possibility that they may have effects like asbestos, which caused a worldwide pandemic of disease in the20th century that continues into present. CNT may exist as fibres or as more compact particles and the asbestos-type hazard only pertains to the fibrous forms of CNT. Exposure to asbestos causes asbestosis, bronchogenic carcinoma, mesothelioma, pleural fibrosis and pleural plaques indicating that both the lungs and the pleura are targets. The fibre pathogenicity paradigm was developed in the 1970s-80s and has a robust structure/toxicity relationship that enables the prediction of the pathogenicity of fibres depending on their length, thickness and biopersistence. Fibres that are sufficiently long and biopersistent and that deposit in the lungs can cause oxidative stress and inflammation. They may also translocate to the pleura where they can be retained depending on their length, and where they cause inflammation and oxidative stress in the pleural tissues. These pathobiological processes culminate in pathologic change - fibroplasia and neoplasia in the lungs and the pleura. There may also be direct genotoxic effects of fibres on epithelial cells and mesothelium, contributing to neoplasia. CNT show some of the properties of asbestos and other types of fibre in producing these types of effects and more research is needed. In terms of the molecular pathways involved in the interaction of long biopersistent fibres with target tissue the events leading to mesothelioma have been a particular area of interest. A variety of kinase pathways important in proliferation are activated by asbestos leading to pre-malignant states and investigations are under way to determine whether fibrous CNT also affects these molecular pathways. Current research suggests that fibrous CNT can elicit effects similar to asbestos but more

  11. A mathematical model for fibro-proliferative wound healing disorders.

    Science.gov (United States)

    Olsen, L; Sherratt, J A; Maini, P K

    1996-07-01

    The normal process of dermal wound healing fails in some cases, due to fibro-proliferative disorders such as keloid and hypertrophic scars. These types of abnormal healing may be regarded as pathologically excessive responses to wounding in terms of fibroblastic cell profiles and their inflammatory growth-factor mediators. Biologically, these conditions are poorly understood and current medical treatments are thus unreliable. In this paper, the authors apply an existing deterministic mathematical model for fibroplasia and wound contraction in adult mammalian dermis (Olsen et al., J. theor. Biol. 177, 113-128, 1995) to investigate key clinical problems concerning these healing disorders. A caricature model is proposed which retains the fundamental cellular and chemical components of the full model, in order to analyse the spatiotemporal dynamics of the initiation, progression, cessation and regression of fibro-contractive diseases in relation to normal healing. This model accounts for fibroblastic cell migration, proliferation and death and growth-factor diffusion, production by cells and tissue removal/decay. Explicit results are obtained in terms of the model processes and parameters. The rate of cellular production of the chemical is shown to be critical to the development of a stable pathological state. Further, cessation and/or regression of the disease depend on appropriate spatiotemporally varying forms for this production rate, which can be understood in terms of the bistability of the normal dermal and pathological steady states-a central property of the model, which is evident from stability and bifurcation analyses. The work predicts novel, biologically realistic and testable pathogenic and control mechanisms, the understanding of which will lead toward more effective strategies for clinical therapy of fibro-proliferative disorders.

  12. Respiratory tract changes in guinea pigs, rats, and mice following a single six-hour exposure to methyl isocyanate vapor

    Energy Technology Data Exchange (ETDEWEB)

    Fowler, E.H.; Dodd, D.E.

    1987-06-01

    Groups of male and female Fischer 344 rats, B6C3F1 mice, and Hartley guinea pigs were exposed once for 6 hr to mean concentrations of 10.5, 5.4, 2.4, 1.0, or 0 (control) ppm of methyl isocyanate (MIC) vapor. Rats and mice were also exposed to 20.4 ppm of MIC. The majority of deaths occurred during postexposure days 1 through 3. The 6-hr LC/sub 50/ values were 6.1 ppm for rats, 12.2 ppm for mice, and 5.4 ppm for guinea pigs. Notable clinical observations during and immediately following MIC exposure were lacrimation, perinasal/perioral wetness, respiratory difficulty (e.g., mouth breathing), decreased activity, ataxia, and hypothermia. Body weight losses were common in all species following MIC exposures of 2.4 ppm or greater. Microscopic lesions included acute necrosis of the epithelial lining throughout the respiratory tract in animals that died shortly after exposure, coupled with congestion, edema, and inflammation. A microscopic lesion that appeared unique to guinea pigs was bronchiolitis obliterans. Additional microscopic lesions observed in some animals that died or were sacrificed at the end of the study (postexposure day 14) consisted of squamous metaplasia of respiratory epithelium in the nasal cavity, which extended into the larynx, trachea, and in some cases, the bronchi. In addition, epithelial regeneration throughout the tract and submucosal fibroplasia in the trachea, bronchi, and bronchioles were observed, the latter lesion being primarily confined to rodents. Only in guinea pigs were there lesions in the 1.0 ppm group attributed to MIC exposure. In conclusion, guinea pigs were more sensitive to the MIC vapor than were rats, which were in turn more sensitive than mice.

  13. Renoprotective effect of curcumin against the combined oxidative stress of diabetes and nicotine in rats.

    Science.gov (United States)

    Ibrahim, Zein Shaban; Alkafafy, Mohamed Elsayed; Ahmed, Mohamed Mohamed; Soliman, Mohamed Mohamed

    2016-04-01

    The progression of diabetic nephropathy (DN) is accelerated by smoking. The current study investigated the ability of curcumin to protect the kidneys against damage from oxidative stress induced by diabetes mellitus (DM) and nicotine (NC). A total of 24 male Wistar rats were divided into four groups of six rats each. DM was induced by a single intraperitoneal injection of streptozotocin 60 mg/kg body weight. DM rats were treated with or without NC in the absence or presence of curcumin for 8 weeks. As compared with the controls, DM rats exhibited reduced serum levels of high density lipoprotein, superoxide dismutase and glutathione peroxidase, and decreased renal mRNA expression levels of synaptopodin, connexin 43 and erythropoietin (EPO), which were further suppressed by NC and restored to normal levels by curcumin treatment. Additionally, DM rats exhibited increases in their lipid profiles (cholesterol, triacylglycerol and phospholipids), oxidative markers (malondialdehyde, γ‑glutamyltranspeptidase and nitric oxide), kidney function markers (urea and creatinine) and the mRNA expression levels of vimentin, desmin, SREBP‑1, iNOS and TGF‑β1. These effects were further enhanced by NC, but counteracted by curcumin treatment. Kidneys from DM rats displayed glomerular hypertrophy, sclerosis and tubulo‑interstitial changes represented by tubular lipid deposition, interstitial mononuclear cell infiltration and fibroplasia. Pancreatic islets exhibited cellular vacuolation, morphological irregularity and damaged or reduced in size β‑cells. These renal and pancreatic changes became more severe following NC treatment and were ameliorated by curcumin. Therefore, NC‑induced DN progression may predominantly operate by increasing oxidative stress, reducing the levels of antioxidants, suppressing EPO levels, and causing perturbations to gap junction and podocyte structure. Curcumin may ameliorate the damaging effects of DM and NC on the kidney through normalization

  14. Componentes ricos em plaquetas na reparação de afecções tendo-ligamentosas e osteo-articulares em animais Components rich in platelets used in wound healing tendon, ligaments and osteo-articular diseases of animals

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    Leandro Maia

    2009-07-01

    Full Text Available O plasma rico em plaquetas e o concentrado de plaquetas são fontes de diversos fatores de crescimento, com grande potencial terapêutico. Uma vez liberados dos grânulos alfa das plaquetas ativadas, esses fatores atuarão no sítio da lesão, estimulando a quimiotaxia, fibroplasia e angiogênese, melhorando assim a reparação tecidual. Embora esses componentes ricos em plaquetas sejam de fácil obtenção e de eficácia comprovada na medicina humana e odontologia, a utilização desses componentes na medicina veterinária é relativamente recente, necessitando ainda de estudos controlados. Neste artigo, os aspectos morfológicos das plaquetas, a ação dos fatores de crescimento e a utilização de componentes ricos em plaquetas na reparação tecidual de estruturas tendo-ligamentosas e osteo-articulares são revisados.Platelet-rich plasma and platelet concentrates are involved in growing factors. Both have great therapeutic potential. When the alpha-granules are released by the active platelet, they act in the lesion site stimulating the chemotaxis, the fiberplasia and the angiogenesis. They improve the regeneration of the tissue. Although these rich platelet components are easy to obtain and efficiently to prove by medicine and dentistry, their use on vet medicine is recent. So, much more control studies need to be done. This article reviews morphological aspects of platelets, action of growing factors and use of components rich in platelet in wound healing tendons, ligaments and osteo-articular structures.

  15. Preparation of fucoidan-chitosan hydrogel and its application as burn healing accelerator on rabbits.

    Science.gov (United States)

    Sezer, Ali Demir; Cevher, Erdal; Hatipoğlu, Fatih; Oğurtan, Zeki; Baş, Ahmet Levent; Akbuğa, Jülide

    2008-12-01

    Treatment of dermal wounds with macromolecular agents such as natural polymers is one of the research areas of the biomaterial science. Fucoidan is a sulphated polysaccharide which is commonly obtained from seaweeds. The great number of studies on the different pharmacological properties of fucoidan is present, but there is limited information about using of fucoidan in the treatment of dermal burns. The aim of this study was to prepare fucoidan-chitosan hydrogels and to investigate their treatment efficiency on dermal burns. Hydrogels were prepared by swelling the polymers in acidic solution and their swelling, mechanical (hardness, cohesiveness and adhesiveness) and bioadhesive properties were investigated. The viscosity and water absorption capacity of formulations increased with increase in the polymer concentration. In contrast to the cohesiveness results, the adhesiveness of hydrogels increased with the polymer concentration. The bioadhesion was changed between 0.012-0.142 mJ x cm(-2) and enhanced with addition of fucoidan into gel formulations. It was formed dermal burns on seven adult male New Zealand white rabbits and the optimum gel formulation applied on the wounds. Control and treatment group biopsy samples were taken on days 7, 14 and 21 and each burn wound site was evaluated histopathologically. No edema was seen in tested groups except control after 3 d treatment. After 7 d treatment, fibroplasia and scar were fixed on wounds treated with fucoidan-chitosan gel and fucoidan solution. The best regeneration on dermal papillary formation and the fastest closure of the wounds were observed in fucoidan-chitosan hydrogels after 14 d treatment. PMID:19043221

  16. Morphological analysis of second-intention wound healing in rats submitted to 16 J/cm 2 λ 660-nm laser irradiation

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    Gonzaga Ribeiro Maria

    2009-01-01

    Full Text Available Background and Objectives : Low-level laser therapy (LLLT has been extensively applied to improve wound healing due to some biostimulatory properties presented by laser arrays apparently able to accelerate the cicatricial repair of soft tissue injuries. However, many controversial results have been reported in the literature, probably as a result of the wide sort of different protocols of photobiomodulation employed in those experiments. The goal of this study was to investigate the effect of a low-dose protocol of LLT on the intensity of the inflammatory response and the pattern of collagen fibers′ deposition during second-intention wound healing in rodents. Materials and Methods : Standard-sized wounds were carried out in the back of 24 male rats. Half of them underwent LLLT treatment (16 J/cm 2 at 660 nm delivered for 7 days. Eight and 14 days after the wounds were performed, the repairing area was removed and stained in HE and Masson′s trichrome, and the inflammatory response, epithelization, and collagen fiber depositions were evaluated. Results : We found that LLLT was able to slightly reduce the intensity of the inflammatory reaction as well as to enhance substantially the epithelization process at both 8 th and 14 th days. In addition, it also appeared to stimulate the deposition of collagen fibers at the final stages of wound healing. Conclusions : The LLLT protocol tested in this study resulted in some improvements in second-intention wound healing in rodents.

  17. A comparative analysis between laparoscopy and open colectomy: assessment of perioperative and oncological outcomes.

    Science.gov (United States)

    Farinetti, Alberto; Bonetti, Luca Reggiani; Migaldi, Mario; Mattioli, Anna Vittoria; Pennella, Sonia; Muratori, Simone; Rossi, Aldo

    2015-01-01

    Il presente studio raffronta due gruppi di pazienti affetti da adenocarcinoma dolo-rettale, sottoposti rispettivamente a colectomia con tecnica open e a videolaparoscopia, mettendone in luce benefici e svantaggi. Si tratta di un’analisi retrospettiva: dal gennaio 2003 e il dicembre 2006 sono stati reclutati 54 pazienti; di questi 26 operati in laparotomia e 28 in laparoscopia. Per la chirurgia laparotomica la durata media dell’intervento è stata di 177.9 minuti (tempo chirurgico) e di 280.4 minuti (tempo di sala operatoria con un minimo di 110 ed un massimo di 360 minuti, con significative differenze in rapporto al tipo di chirurgia effettuata e la storia clinica del paziente. Per la chirurgia laparoscopica la durata media è stata di 293 minuti (range 135-520), con significative differenze dipendenti dalla porzione di intestino asportata. Il raffronto delle due tecniche chirurgiche, laparotomica versus lapsroscopica, ha rivelato alcune differenze. La durata della resezione è stata maggiore per la laparoscopia se confrontata con la tecnica tradizionale. Entrambi gli approcci rappresentano tecniche convenienti, sicure ed oncologicamente corrette. La laparoscopia mostra maggiori vantaggi in termini di controllo del dolore, assenza di estese cicatrici, riscontro di laparoceli e di degenza post operatoria comparata con la tecnica laparotomica.

  18. Nasal meatus plasty: a contribution to plastic reconstruction of the nasal valve during midfacial degloving

    Directory of Open Access Journals (Sweden)

    Lorenz, Kai J.

    2014-05-01

    Full Text Available Midfacial degloving is a proven method for easily accessing the midface, the nasal pyramid, the maxillary and ethmoidal sinuses, the orbits, as well as the anterior skull base. Indications for this method of access mainly include tumour resections in the area of the midface, the septum, the maxillary sinus, the paranasal to the sphenoidal sinus as well as the clivus. In addition, this method of access allows for the exposure of the bony structures of the midface in the event of extensive fractures.In general, this method of access combines an incision in the oral vestibule and circular incisions in the nasal vestibule area in order to release the nasal pyramid.After removing the facial wall of the maxillary sinus, extensive exposure of the surgical site is possible.One disadvantage of this method of access is the difficult reconstruction of the nasal valve area, which often leads to cicatricial stenoses and difficulties with breathing through the nose. Furthermore, wound healing problems and osteoradionecrosis in the area of the lateral margin of the anterior nasal aperture after replantation of the facial wall of the maxillary sinus have been described, because in this area sufficient soft tissue coverage cannot be ensured when a conventional technique is used.We describe a soft tissue flap pedicled in the cranial and caudal directions in the nasal valve area which makes both the reconstruction of the nasal vestibule and sufficient soft tissue coverage of the anterior nasal aperture possible.

  19. Follicular and scarring disorders in skin of color: presentation and management.

    Science.gov (United States)

    Madu, Pamela; Kundu, Roopal V

    2014-08-01

    Skin of color, also known as ethnic skin, is described as skin of individuals of African, Asian, Hispanic, Native-American, Middle Eastern, and Pacific Island backgrounds. Differences in hair morphology, hair grooming, cultural practices, and susceptibility to keloid scarring exist within these populations and have been implicated in hair, scalp, and skin disorders. Acne keloidalis (AK), central centrifugal cicatricial alopecia (CCCA), dissecting cellulitis of the scalp (DCS), pseudofolliculitis barbae (PFB), traction alopecia (TA), and keloids are the most prevalent follicular and scarring disorders in skin of color. They have been associated with disfigurement, permanent hair loss, emotional distress, and decreased quality of life. Hair grooming practices, such as the use of chemical relaxers, heat straightening, and tight braiding and weaving can cause scalp irritation and follicular damage and are linked to the pathogenesis of some of these conditions. Consequently, patient education and behavior modifications are integral to the prevention and management of these disorders. Scarring disorders are also of concern in ethnic populations. Keloid scarring is more prevalent in individuals of African, Asian, and Hispanic descent. The scarring alopecia CCCA is almost exclusively seen in patients of African descent. Therapeutic regimens such as intralesional corticosteroids, surgical excision, and laser therapy can be effective for these follicular and scarring disorders, but carry a risk of dyspigmentation and keloid scarring. Ethnic skin and hair may present unique challenges to the clinician, and knowledge of these differences is essential to providing quality care.

  20. O autocuidado para o tratamento de úlcera de perna falciforme: orientações de enfermagem

    Directory of Open Access Journals (Sweden)

    Amanda Martins

    2013-09-01

    Full Text Available O objetivo deste estudo foi verificar a eficácia do Programa do Autocuidado, pela progressão do processo cicatricial de úlcera da perna falciforme. Trata-se de um estudo longitudinal com abordagem quantitativa realizado com 40 clientes no setor de curativos de uma instituição de saúde pública, especializada no tratamento hematológico, situada no Rio de Janeiro. Para a coleta dos dados foi utilizado um instrumento aplicado no momento das consultas de enfermagem. Os dados foram analisados com o auxílio dos modelos de Cox, regressão logística e árvores de classificação. Verificou-se a eficácia do Programa do Autocuidado em função da cicatrização total das ulcerações de 23 clientes, e observou-se que úlceras agudas com um tempo de manifestação até 60 meses têm a probabilidade de cura de 95%. A partir da adesão dos clientes e dos resultados alcançados, o programa firmou-se como modalidade terapêutica, sendo incorporado como programa institucional.

  1. Clinical And Morphological Androgenic Status Characteristics At Children Suffering From Hypospadias And Its Influence On Results Of Surgical Correction

    Directory of Open Access Journals (Sweden)

    F.K. Napolnikov

    2009-09-01

    Full Text Available The goal of this article is to estimate the androgenic status and analyze its influence on the surgical treatment of hypospadias. From 2000 till 2008 there were 209 children under treatment, whose age varied from 8 months till 15 years old (average age — 4,5+ 1,5. 49 patients were subjected to clinical, humoral and morphological study. Preoperational preparation was carried out by testosterone medications. The comparison group consisted of 10 boys with cicatricial phimosis. The patients with the medium and back forms of hypospadias suffered from the androgenic deficit characterized by proximal level of meatus ectopia, diminution of penis length and prostate volume, decrease of blood vessels in deep layers of penis skin. The testosterone pre-operational medication of patients makes possible to improve the results of surgical correction due to blood supply of plastic material. On the basis of recieved data logistically regressive model has been worked out and the prognosis of results has been estimated

  2. Delineating immune-mediated mechanisms underlying hair follicle destruction in the mouse mutant defolliculated.

    Science.gov (United States)

    Ruge, Fiona; Glavini, Aikaterini; Gallimore, Awen M; Richards, Hannah E; Thomas, Christopher P; O'Donnell, Valerie B; Philpott, Michael P; Porter, Rebecca M

    2011-03-01

    Defolliculated (Gsdma3(Dfl)/+) mice have a hair loss phenotype that involves an aberrant hair cycle, altered sebaceous gland differentiation with reduced sebum production, chronic inflammation, and ultimately the loss of the hair follicle. Hair loss in these mice is similar to that seen in primary cicatricial, or scarring alopecias in which immune targeting of hair follicle stem cells has been proposed as a key factor resulting in permanent hair follicle destruction. In this study we examine the mechanism of hair loss in GsdmA3(Dfl)/+ mice. Aberrant expression patterns of stem cell markers during the hair cycle, in addition to aberrant behavior of the melanocytes leading to ectopic pigmentation of the hair follicle and epidermis, indicated the stem cell niche was not maintained. An autoimmune mechanism was excluded by crossing the mice with rag1-/- mice. However, large numbers of macrophages and increased expression of ICAM-1 were still present and may be involved either directly or indirectly in the hair loss. Reverse transcriptase-PCR (RT-PCR) and immunohistochemistry of sebaceous gland differentiation markers revealed reduced peroxisome proliferator-activated receptor-γ (PPARγ), a potential cause of reduced sebum production, as well as the potential involvement of the innate immune system in the hair loss. As reduced PPARγ expression has recently been implicated as a cause for lichen planopilaris, these mice may be useful for testing therapies.

  3. Short Term Outcome of Anterior Lamellar Reposition in Treating Trachomatous Trichiasis

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    Rania A. Ahmed

    2015-01-01

    Full Text Available Purpose. To evaluate the outcome of anterior lamellar reposition (ALR in treating trachomatous trichiasis. Methods. Patients with trachomatous trichiasis or entropion with short tarsus were treated by ALR between February 2009 and November 2013. This included splitting of the lid margin behind the aberrant lash line to separate the lid lamellae. The anterior lamella was recessed and fixated using 4/0 silk sutures. The extra lashes and their routes were excised. Sutures were removed by the 3rd week and patients completed 6 months of follow-up. Recurrence of ≤5 lashes was treated by electrolysis. Results. The study included 752 eyelids (445 patients; 58.4% females, 41.6% males, mean age 53.2 ± 6.9 y. 179 (25.1% lids had entropion while 287 (64.5% patients had corneal affection. By the third week, 2.66% lid had trichiasis while 30.8% had no rubbing lashes. By the 6th month, 14.9% of lids showed recurrence while 66.1% were completely cured (CI = 0.63–0.69 and 19% had partial success (CI = 0.16–0.21. Abnormal lid appearance persisted in 2.66% and 12.9% required another surgery. Conclusion. ALR is a good option for treating trachomatous trichiasis especially without cicatricial entropion. Excision of dysplastic lashes is thought to augment the surgical outcome.

  4. Pulmonary langerhans cell histiocytosis

    Directory of Open Access Journals (Sweden)

    Suri Harpreet S

    2012-03-01

    Full Text Available Abstract Pulmonary Langerhans Cell Histiocytosis (PLCH is a relatively uncommon lung disease that generally, but not invariably, occurs in cigarette smokers. The pathologic hallmark of PLCH is the accumulation of Langerhans and other inflammatory cells in small airways, resulting in the formation of nodular inflammatory lesions. While the overwhelming majority of patients are smokers, mechanisms by which smoking induces this disease are not known, but likely involve a combination of events resulting in enhanced recruitment and activation of Langerhans cells in small airways. Bronchiolar inflammation may be accompanied by variable lung interstitial and vascular involvement. While cellular inflammation is prominent in early disease, more advanced stages are characterized by cystic lung destruction, cicatricial scarring of airways, and pulmonary vascular remodeling. Pulmonary function is frequently abnormal at presentation. Imaging of the chest with high resolution chest CT scanning may show characteristic nodular and cystic abnormalities. Lung biopsy is necessary for a definitive diagnosis, although may not be required in instances were imaging findings are highly characteristic. There is no general consensus regarding the role of immunosuppressive therapy in smokers with PLCH. All smokers must be counseled on the importance of smoking cessation, which may result in regression of disease and obviate the need for systemic immunosuppressive therapy. The prognosis for most patients is relatively good, particularly if longitudinal lung function testing shows stability. Complications like pneumothoraces and secondary pulmonary hypertension may shorten life expectancy. Patients with progressive disease may require lung transplantation.

  5. Nasal meatus plasty: a contribution to plastic reconstruction of the nasal valve during midfacial degloving.

    Science.gov (United States)

    Lorenz, Kai J; Maier, Heinz; Wilde, Frank

    2014-01-01

    Midfacial degloving is a proven method for easily accessing the midface, the nasal pyramid, the maxillary and ethmoidal sinuses, the orbits, as well as the anterior skull base. Indications for this method of access mainly include tumour resections in the area of the midface, the septum, the maxillary sinus, the paranasal to the sphenoidal sinus as well as the clivus. In addition, this method of access allows for the exposure of the bony structures of the midface in the event of extensive fractures. In general, this method of access combines an incision in the oral vestibule and circular incisions in the nasal vestibule area in order to release the nasal pyramid. After removing the facial wall of the maxillary sinus, extensive exposure of the surgical site is possible. One disadvantage of this method of access is the difficult reconstruction of the nasal valve area, which often leads to cicatricial stenoses and difficulties with breathing through the nose. Furthermore, wound healing problems and osteoradionecrosis in the area of the lateral margin of the anterior nasal aperture after replantation of the facial wall of the maxillary sinus have been described, because in this area sufficient soft tissue coverage cannot be ensured when a conventional technique is used. We describe a soft tissue flap pedicled in the cranial and caudal directions in the nasal valve area which makes both the reconstruction of the nasal vestibule and sufficient soft tissue coverage of the anterior nasal aperture possible. PMID:26504717

  6. Lichen planopilaris: update on pathogenesis and treatment.

    Science.gov (United States)

    Baibergenova, Akerke; Donovan, Jeff

    2013-01-01

    Lichen planopilaris (LPP) is considered to be a follicular variant of lichen planus. Clinical variants include classic LPP, frontal fibrosing alopecia, and the Graham-Little-Piccardi-Lassueur syndrome. The pathogenesis of LPP remains to be fully elucidated, but like other cicatricial alopecias involves the irreversible destruction of hair follicle stem cells and loss of a hair follicle's capacity to regenerate itself In the early stages of LPP, patients may have scalp pruritus, burning, tenderness, and increased hair shedding. A scalp biopsy shows a lymphocytic infiltrate involving the isthmus and infundibulum. Apoptotic cells present in the external root sheath and concentric fibrosis surrounds the hair follicle. Treatment is prescribed with the goal to alleviate patient symptoms and to halt the progression of hair loss. Treatment involves use of potent topical corticosteroids and/or intralesional corticosteroids. Options for systemic treatment include anti-inflammatory agents such as hydroxychloroquine, tetracyclines, pioglitazones, and immunosuppressive medications such as cyclosporine, mycophenolate mofetil, or systemic corticosteroids. Hair transplantation may also be an option if the disease has been in clinical remission. The management of LPP can sometimes be challenging and additional research is needed to improve outcomes for patients. PMID:23930355

  7. Clinical analysis of bronchoscopic electrocoagulation in pediatric patients.

    Science.gov (United States)

    Ni, Caiyun; Yu, Huafeng; Han, Xiaorong; Meng, Chen; Zhang, Yanqing

    2014-01-01

    This study is to explore the efficacy and safety of bronchoscopic electrocoagulation treatment for pediatric disease of poor ventilation. Seventy pediatric patients of airway stenosis and obstruction as well as pharyngeal and laryngeal cysts received bronchoscopic electrocoagulation treatment, including 15 cases of epiglottic cyst, 13 cases of cicatricial hyperplasia of fibrous tissue after trachea intubation, 5 cases of foreign body in bronchus and 37 cases of endobronchial tuberculosis. Before and after the last electrocoagulation treatment, treatment efficacy was evaluated by examining the patients' clinical presentations and lesions in airway under bronchoscope, examining chest CT and pulmonary function, and estimating pulmonary atelectasis and ventilation function. Seventy cases of pediatric patients were treated by bronchoscopic electrocoagulation, with the total treatment number of 106 times. Among them, 66 cases were treated with marked efficacy and 4 cases were with effective treatment. There was no invalid treatment. The treatment efficacy was 100% without complications. Bronchoscopic electrocoagulation treatment is a fast, effective and safe therapeutic method in treating airway stenosis and obstruction, such as foreign body in bronchus, granulation tissue hyperplasia, and epiglottic cysts. It is worthy of being widely applied in clinic.

  8. Balloon sinuplasty: a new concept in the endoscopic nasal surgery

    Directory of Open Access Journals (Sweden)

    Nogueira Júnior, João Flávio

    2008-12-01

    Full Text Available Introduction: Sinus diseases affect millions of people annually. Clinical treatment is effective in most patients, but in case of failure of this therapy the functional endoscopic surgery is currently the treatment choice for surgical treatment. The objective of the functional endoscopic surgery is to increase the aeration and drainage of the involved paranasal sinuses, which allows for the adequate functioning of the nasal mucosa mucociliary clearance. However, this method still has some limitations, mainly because it removes the nasal mucosa and bone tissue, and it may lead to physiologic alterations of the nasosinusal mucosa and cicatricial fibrosis. Many of these patients could be benefited from less invasive methods, with larger nasal mucosa preservation. Since 2006, an even less invasive procedure was remarked in our specialty: the balloon dilatation of the paranasal sinus ostia. Objective: The objective of this article is to define the concept of sinuplasty, its action mechanism, and present the necessary material for the procedures performance; to describe the techniques with the equipment in a nasosinusal endoscopic surgery simulator model and review the current literature about the indications, complications, results, and follow-up of patients submitted to this procedure. Balloon sinuplasty is safe and appears to be effective in the improvement of the quality of life of patients not responsive to conventional clinical therapy. New applications and indications for this equipment should be described and researched.

  9. Clinicoepidemiological Observational Study of Acquired Alopecias in Females Correlating with Anemia and Thyroid Function

    Directory of Open Access Journals (Sweden)

    Kirti Deo

    2016-01-01

    Full Text Available Alopecia can either be inherited or acquired; the latter, more common, can be diffuse, patterned, and focal, each having cicatricial and noncicatricial forms. This observational study of 135 cases in a semiurban Indian population aimed to detect the prevalence of various forms of acquired alopecia in females and correlate the same with levels of hemoglobin, serum ferritin, triiodothyronine, thyroxin, and thyroid stimulating hormone. The majority (84, 62.2% of our cases of alopecia had telogen effluvium followed by female pattern alopecia (32, 23.7%. Stress (86, 63.7%, topical application of chemicals (72, 53.3%, systemic medications for concurrent illnesses (62, 5%, and pregnancy (14, 10.3% were the common exacerbating factors. Neither low hemoglobin (12 μg/L. Though lack of vitamin B12 testing was a limitation of our study, its deficiency could be the probable cause of iron deficiency as the majority (58, 64.4% of these cases, as indeed majority (89, 65.4% of our study population, were vegetarians. Thyroid disorders (23, 17%, including 9 newly diagnosed were not of significance statistically.

  10. Delineating immune-mediated mechanisms underlying hair follicle destruction in the mouse mutant defolliculated.

    Science.gov (United States)

    Ruge, Fiona; Glavini, Aikaterini; Gallimore, Awen M; Richards, Hannah E; Thomas, Christopher P; O'Donnell, Valerie B; Philpott, Michael P; Porter, Rebecca M

    2011-03-01

    Defolliculated (Gsdma3(Dfl)/+) mice have a hair loss phenotype that involves an aberrant hair cycle, altered sebaceous gland differentiation with reduced sebum production, chronic inflammation, and ultimately the loss of the hair follicle. Hair loss in these mice is similar to that seen in primary cicatricial, or scarring alopecias in which immune targeting of hair follicle stem cells has been proposed as a key factor resulting in permanent hair follicle destruction. In this study we examine the mechanism of hair loss in GsdmA3(Dfl)/+ mice. Aberrant expression patterns of stem cell markers during the hair cycle, in addition to aberrant behavior of the melanocytes leading to ectopic pigmentation of the hair follicle and epidermis, indicated the stem cell niche was not maintained. An autoimmune mechanism was excluded by crossing the mice with rag1-/- mice. However, large numbers of macrophages and increased expression of ICAM-1 were still present and may be involved either directly or indirectly in the hair loss. Reverse transcriptase-PCR (RT-PCR) and immunohistochemistry of sebaceous gland differentiation markers revealed reduced peroxisome proliferator-activated receptor-γ (PPARγ), a potential cause of reduced sebum production, as well as the potential involvement of the innate immune system in the hair loss. As reduced PPARγ expression has recently been implicated as a cause for lichen planopilaris, these mice may be useful for testing therapies. PMID:21160494

  11. ¿Es necesaria la reconstrucción de la conjuntiva?: Trabajo experimental en conejos albinos para evaluar la neogénesis de la conjuntiva

    Directory of Open Access Journals (Sweden)

    E. A. Moretti

    2007-03-01

    Full Text Available En los defectos de espesor total del párpado inferior de gran magnitud, siempre ha sido regla de oro la reconstrucción de la lamela posterior (tarso y conjuntiva palpebral. Esto es debido a que el tono del músculo orbicularis oculi no alcanza a mantener el soporte necesario para resistir la acción de la gravedad y/o contractura cicatricial. Además la ausencia de conjuntiva provocaría lesiones sobre la córnea ocular. Es por ello que el empleo de injertos compuestos condromucosos ha sido insustituible. El presente trabajo de investigación fue realizado en 20 conejos albinos con el objeto de evaluar la posibilidad de emplear cartílago auricular para la reconstrucción del tarso sin colocación de mucosa a modo de conjuntiva sobre dicho cartílago. Los resultados obtenidos permiten confirmar por diferentes tinciones histológicas sobre biopsias comparadas con zonas testigo, el crecimiento de tejido conjuntival sobre el pericondrio sin provocar lesiones oculares (neogénesis de conjuntiva. Los hallazgos encontrados provocan importantes y sustanciales cambios en la cirugía reconstructiva del párpado inferior debido a que de esta manera, no sería necesaria la reconstrucción de la conjuntiva palpebral, siendo útil exclusivamente la colocación de cartílago.

  12. Avaliação do uso de pomada à base de sementes de jaqueira (Artocarpus heterophyllus Lam na terapêutica tópica de feridas

    Directory of Open Access Journals (Sweden)

    R. N.L. Vitorino Filho

    2009-07-01

    Full Text Available As propriedades cicatrizantes da jaqueira (Artocarpus heterophyllus Lam são atribuídas a uma proteína encontrada na semente de sua fruta que, em casos de queimaduras de pele, proporciona a regeneração do tecido danificado em vez da substituição por tecido conjuntivo fibroso. Objetivando avaliar macro e microscopicamente o efeito da pomada formulada com o pó obtido a partir de sementes de jaca na cicatrização, por segunda intenção, de feridas cutâneas em camundongos, limpas e infectadas experimentalmente por Staphylococcus aureus, realizou-se o estudo em 96 camundongos nos quais foram feitas feridas experimentais na região dorso-lateral. Cada grupo, com 12 animais, recebeu um tipo de tratamento. O grupo GI serviu como controle para feridas limpas, o grupo GII foi o controle para feridas infectadas e os demais foram tratados topicamente com pomada à base de semente de jaca em diferentes esquemas de administração. Os animais foram avaliados diariamente e sacrificados cinco, 10 e 13 dias após a cirurgia, sendo removido o tecido cicatricial e circunjacente para avaliação histológica. Os resultados mostraram que não houve diferença estatisticamente significativa entre os tratamentos. Palavras-chave: camundongos; cicatrização; feridas; jaca; Artocarpus heterophyllus Lam; lectina.

  13. Clinical and Histologic Evaluation of Platelet-Rich Fibrin Accelerated Epithelization of Gingival Wound

    Science.gov (United States)

    Bansal, Mansi; Kumar, Ashish; Puri, Komal; Khatri, Manish; Gupta, Geeti; Vij, Hitesh

    2016-01-01

    The foremost indication for gingival depigmentation is patient demand for improved aesthetics. In most cases after the removal of pigmented layer, the area is covered with periodontal packs. These dressings have no curative properties. They only minimise the likelihood of surface trauma during mastication. However, platelet-rich fibrin (PRF) accelerates wound healing by effective neovascularisation and promoting fast cicatricial tissue remodelling. In the present split mouth study, PRF membrane was applied in the first quadrant and non-eugenol dressing (Coe-Pack) in the second quadrant after depigmentation. Clinical evaluation of epithelization with toluidine blue revealed that PRF treated sites stained substantially less indicating better wound healing as compared to Coe-Pack sites, which appeared more erythematous after 5 days. The histologic evaluation also revealed greater inflammatory cell infiltrate on Coe-Pack sites as compared to PRF. Thus, PRF membrane as a periodontal dressing is a successful approach to protect the raw wound area of the depigmented site to reduce healing time and patient discomfort.

  14. Treatment strategies in mucous membrane pemphigoid

    Directory of Open Access Journals (Sweden)

    Ann G Neff

    2008-06-01

    Full Text Available Ann G Neff, Matthew Turner, Diya F MutasimDepartment of Dermatology, University of Cincinnati, Cincinnati, OH, USAAbstract: Mucous membrane pemphigoid (MMP is an autoimmune blistering disorder that is characterized by subepithelial bullae. Various basement membrane zone components have been identified as targets of autoantibodies in MMP. Considerable variability exists in the clinical presentation of MMP. Mucous membranes that may be involved include the oral cavity, conjunctiva, nasopharynx, larynx, esophagus, genitourinary tract, and anus. A multidisciplinary approach is essential in the management of MMP. Early recognition of this disorder and treatment may decrease disease-related complications. The choice of agents for treatment of MMP is based upon the sites of involvement, clinical severity, and disease progression. For more severe disease, or with rapid progression, systemic corticosteroids are the agents of choice for initial treatment, combined with steroid-sparing agents for long-term maintenance. Due to the rarity of this disease, large controlled studies comparing the efficacy of various agents are lacking.Keywords: mucous membrane pemphigoid, cicatricial pemphigoid

  15. Rare case of isolated osteochondroma of the zygomatic bone: an endoscopic-assisted approach.

    Science.gov (United States)

    Romano, Antonio; Dell'Aversana, Giovanni; Corvino, Raffaele; Abbate, Vincenzo; Iaconetta, Giorgio; Califano, Luigi

    2015-11-03

    L’osteocondroma è una neoplasia benigna che nel distretto cranio-facciale colpisce spesso il corpo ed il ramo mandibolare e soltanto di rado può interessare il processo coronoide e l’arco zygomatico. In questo articolo descriviamo un raro caso di osteocondroma isolato dell’osso zygomatico trattato mediante approccio chirurgico intraorale endoscopicamente assistito ed in letteratura non sono riportati altri casi di questa patologia trattati con procedure endoscopicamente assistite. Una donna caucasica di cinquantadue anni, è stata osservata nel nostro reparto nel mese di marzo del 2012, la paziente lamentava dolore in regione zygomatica destra. La tomografia computerizzata (TC) del distretto osseo interessato mostrava una lesione sessile non definita. Il sospetto diagnostico è stato di osteocondroma. L’intervento è stato realizzato in anestesia generale mediante approccio intraorale endoscopicamente assistito. All’esame istologico del campione operatorio è stata confermata la diagnosi di osteocondroma. Nell’immediato post operatorio la paziente non ha presentato edema, dolore o febbre. L’uso dell’endoscopia nel trattamento chirurgico di questa patologia quindi ha consentito di ottenere una maggiore precisione e una maggiore rispetto delle strutture anatomiche. L’approccio intraorale ci garantisce l’assenza di cicatrici visibili e l’ausilio dell’endoscopia ci consente di avere una migliore visione di tutte le strutture anatomiche, una buona gestione della patologia riducendo quindi il rischio di complicanze intraoperatorie quali: fratture patologiche e lesioni del VII nervo cranico.

  16. Distinct colonoscopy findings of microscopic colitis: Not so microscopic after all?

    Institute of Scientific and Technical Information of China (English)

    Anastasios Koulaouzidis; Athar A Saeed

    2011-01-01

    Microscopic colitis (MC) is considered an "umbrella term", comprising two subtypes, i.e., collagenous colitis (CC) and lymphocytic colitis (LC). They are classically associated with normal or unremarkable colonoscopy. In the last few years, reports have been published revealing findings that are thought to be characteristic or pathognomonic of MC, especially CC. A systematic electronic and manual search of PubMed and EMBASE (to December 2010), for publications on distinct endo-scopic findings in MC, resulted in 42 relevant reports for inclusion in this review. Eighty eight patients with collagenous colitis were presented. Only one publication describing a distinct endoscopic pattern in LC was found. Typical findings in CC are alteration of the vascular mucosal pattern, mucosal nodularity, a sequence of change from mucosal defects to mucosal cicatricial lesions, and perhaps (although of doubtful relevance) mucosal pseudomembranes. A causal connection of mucosal defects with the use of lansoprazole seems to exist. Adoption of the proposed lesion description herein is recommended in order to improve homogeneity of future reports.

  17. Mucous membrane pemphigoid with exclusive gingival involvement: Report of a case and review of literature

    Directory of Open Access Journals (Sweden)

    Shamimul Hasan

    2012-01-01

    Full Text Available According to Sir William Osler, Mouth is the mirror of the body which reflects systemic -diseases. The oral mucosa may be affected by a variety of mucocutaneous diseases and oral lesions may occur first or very early in several mucocutaneous disorders. The erosive gingival lesions associated with vesiculobullous diseases such as lichen planus, cicatricial pemphigoid, and pemphigus vulgaris have been collectively referred to as "Desquamative gingivitis" (DG. Gingival desquamation is a clinical sign in which the gingiva appears reddish, painful, glazed and friable with destruction of the epithelium. This gingival desquamation is due to various disease processes in gingiva. The disease process may be a localized disease of gingiva or a systemic disease which manifests in the gingiva. It is important to be aware of this rare clinical entity so as to distinguish DG from plaque induced gingivitis which is an extremely common condition, easily recognized and treated daily by the dental surgeon. Accurate diagnosis and effective treatment of these lesions may greatly diminish or reverse disease progression. Here by, we present a case of mucous membrane pemphigoid presenting as gingival desquamation in a 45 year old female. Our patient presented with generalized erythematous gingiva and gingival desquamation involving the free, attached and marginal gingiva of left maxillary and mandibular dentition. However, other mucosal and skin involvement was not appreciated in the present case. Thorough history, clinical examination, histopathology and immunofluorescence studies helped us to arrive at the diagnosis of this rare sub-epithelial blistering disorder.

  18. [Magnetic resonance tomography in late sequelae of spinal and spinal cord injuries].

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    Kravtsov, A K; Akhadov, T A; Sachkova, I Iu; Belov, S A; Chernenko, O A; Panova, M M

    1993-01-01

    Magnetic-resonance tomography (MRT) helped obtain a high-resolution image characterized by high sensitivity in respect of soft tissue contrast visualization and providing direct imaging of the spinal cord and its radicles. This method is useful in the diagnosis of injuries to the spine and cord. A total of 64 patients of both sexes aged 6 to 67 were examined. The primary diagnosis of traumatic changes in the spine and cord was confirmed by MRT in only 62% of cases. Two groups of patients were singled out: with acute and chronic injuries, subdivided into subgroups with and without spinal cord dysfunction. The detected changes were divided into extramedullary (traumatic disk hernias, compression of the cord or radicles with a dislocated bone fragment, epidural hematoma) and intramedullary (edema, hemorrhages, spinal cord disruption); MRT diagnosis of intramedullary changes is particularly important, more so in the absence of bone injuries. In remote periods after the trauma the clinical picture was determined by spinal canal stenosis, cicatricial atrophic and adhesive changes eventually blocking the liquor space. Intramedullary changes presented as spinal cord cysts or syringomyelia. A classification of the detected changes by the types of injuries and their aftereffects is presented in the paper. The authors emphasize the desirability of MRT in spinal injuries with signs of cord dysfunction. PMID:7801568

  19. Aflatoxicose em cães na região Sul do Rio Grande do Sul

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    Angelita dos Reis Gomes

    2014-02-01

    Full Text Available Descrevem-se os aspectos clinicopatológicos de casos de aflatoxicose em cães no Sul do Rio Grande do Sul. Foi realizado um estudo retrospectivo dos casos diagnosticados como aflatoxicose em cães necropsiados no Laboratório Regional de Diagnóstico (LRD da Faculdade de Veterinária da Universidade Federal de Pelotas (UFPel no período de 1978 a 2012. Em quatro casos o diagnóstico foi confirmado pela detecção de níveis de 89 a 191 ppb de aflatoxinas B1 e G1 no alimento dos cães. De um total de 27 cães com cirrose hepática, em seis havia suspeita de aflatoxicose pelas lesões macro e microscópicas e pelo tipo de alimentação que os cães recebiam. Os sinais clínicos nos casos confirmados e nos suspeitos caracterizaram-se por apatia, diarreia, icterícia e ascite, com evolução para morte em 8 a 30 dias nos casos confirmados e em 15 a 60 dias nos casos suspeitos. A dieta era à base de derivados de milho ou arroz, farelo de amendoim e, em um caso suspeito, a dieta era ração comercial. As alterações macroscópicas caracterizaram-se por ascite, icterícia, fígado aumentado de tamanho, com ou sem nódulos, hemorragia nas serosas, conteúdo intestinal hemorrágico. Os casos foram classificados de acordo com o padrão histológico principal, caracterizado por vacuolização difusa no citoplasma de hepatócitos nos casos agudos, por proliferação de ductos biliares e discreta fibroplasia nos casos subagudos e por fibrose acentuada nos casos crônicos. Aparentemente, a enfermidade não é importante como causa de morte em cães na região, no entanto, alerta-se para a possibilidade de casos com diagnóstico de cirrose hepática sem causa determinada serem causados por aflatoxicose.

  20. Intramammary administration of platelet concentrate as an unconventional therapy in bovine mastitis: first clinical application.

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    Lange-Consiglio, A; Spelta, C; Garlappi, R; Luini, M; Cremonesi, F

    2014-10-01

    Bovine udder infections induce a variety of changes in gene expression of different growth factors that may suggest their possible role in glandular tissue protection or repair processes. Growth factors and also chemokines and cytokines may act synergistically to increase the infiltration of neutrophils and macrophages to promote angiogenesis, fibroplasia, matrix deposition, and, ultimately, re-epithelialization. Considering the vast applications, typically in human medicine, of platelet concentrate (PC) and its ease of preparation, the aim of our study was to evaluate an alternative therapy to stimulate the regeneration of glandular tissue, administering a concentration in excess of the growth factors contained in the PC. In each one of the 3 farms examined in the trial, PC was prepared from donor cows in good health, free from infections, and with no records of medications administered during the previous 2 mo. The platelet produced in one farm was used only for treating the cows of the same farm in a heterologous way. A total of 229 mastitic quarters were divided in 3 groups: antibiotic group (treated with intramammary antibiotic), antibiotic and PC group (treated intramammarily with antibiotics in association with PC), and PC group (treated with intramammary PC alone). The diagnosis of mastitis was based on somatic cell count and bacteriological evaluation of the milk from the affected quarter. Platelet concentrate, alone or in association with antibiotic, was used for 3 consecutive days as an unconventional therapy in bovine acute and chronic mastitis. Our data show that the associated action of antibiotic and PC performed significantly better than the antibiotic alone, either for the recovery of the affected mammary quarters or for somatic cell count reduction. In the same way, the association antibiotic plus PC showed significantly fewer relapses compared with the antibiotic alone, either for acute or chronic mastitis. The treatment with only PC did not show

  1. Fibromuscular dysplasia

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    Jeunemaitre Xavier

    2007-06-01

    Full Text Available Abstract Fibromuscular dysplasia (FMD, formerly called fibromuscular fibroplasia, is a group of nonatherosclerotic, noninflammatory arterial diseases that most commonly involve the renal and carotid arteries. The prevalence of symptomatic renal artery FMD is about 4/1000 and the prevalence of cervicocranial FMD is probably half that. Histological classification discriminates three main subtypes, intimal, medial and perimedial, which may be associated in a single patient. Angiographic classification includes the multifocal type, with multiple stenoses and the 'string-of-beads' appearance that is related to medial FMD, and tubular and focal types, which are not clearly related to specific histological lesions. Renovascular hypertension is the most common manifestation of renal artery FMD. Multifocal stenoses with the 'string-of-beads' appearance are observed at angiography in more than 80% of cases, mostly in women aged between 30 and 50 years; they generally involve the middle and distal two-thirds of the main renal artery and in some case also renal artery branches. Cervicocranial FMD can be complicated by dissection with headache, Horner's syndrome or stroke, or can be associated with intracerebral aneurysms with a risk of subarachnoid or intracerebral hemorrhage. The etiology of FMD is unknown, although various hormonal and mechanical factors have been suggested. Subclinical lesions are found at arterial sites distant from the stenotic arteries, and this suggests that FMD is a systemic arterial disease. It appears to be familial in 10% of cases. Noninvasive diagnostic tests include, in increasing order of accuracy, ultrasonography, magnetic resonance angiography and computed tomography angiography. The gold standard for diagnosing FMD is catheter angiography, but this invasive procedure is only used for patients in whom it is clinically pertinent to proceed with revascularization during the same procedure. Differential diagnosis include

  2. The influence of low-level laser therapy on biomodulation of collagen and elastic fibers A influência da terapia a laser de baixa densidade de energia na biomodulação das fibras colágenas e elásticas

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    Lívia Souza Pugliese

    2003-12-01

    Full Text Available The study of low-level laser therapy upon extracellular matrix elements is important to understand the wound healing process under this agent. However, little is known about the interference of laser light in relation to collagen and elastic fibers. Cutaneous wounds were performed on the back of 72 Wistar rats and a Ga-Al-As low-level laser was punctually applied with different energy densities. The animals were killed after 24, 48, 72 hours and 5, 7 and 14 days. Tissues were stained with hematoxilin-eosin, sirius red fast green and orcein and then analyzed. It was observed that the treated group exhibited larger reduction of edema and inflammatory infiltrate. The treated animals presented a larger expression of collagen and elastic fibers, although without statistical significance (p > 0.05. Treatment with a dosage of 4 J/cm² exhibited more expressive results than that with 8 J/cm². In this study, the authors concluded that low-level laser therapy contributed to a larger expression of collagen and elastic fibers during the early phases of the wound healing process.O estudo da terapia a laser de baixa densidade de energia sobre os diversos constituintes da matriz extracelular é crucial para o entendimento do processo cicatricial sob esse agente. Todavia, pouco se sabe sobre a interferência do laser em relação às fibras colágenas e elásticas. Realizaram-se ferimentos cutâneos padronizados no dorso de setenta e dois ratos Wistar e, em seguida, aplicação pontual do raio laser de baixa potência do tipo Arseneto de Gálio-Alumínio (Ga-Al-As com diferentes densidades de energia. Os animais foram sacrificados com 24, 48 e 72 horas e aos 5, 7 e 14 dias. Procedeu-se à análise das secções teciduais coradas por hematoxilina-eosina, sírius vermelho e orceína. Observou-se, que nos grupos submetidos à terapia a laser, houve maior redução do edema e infiltrado inflamatório. Os animais tratados apresentaram uma maior expressão de fibras

  3. Aspectos clínicos e macroscópicos da palatoplastia imediata com implante de cartilagem da pina articular, conservada em glicerina a 98%, após indução experimental de fenda palatina em cães Clinic and macroscopic view of immediate palatoplasty with auricular pinna cartilage preserved in 98% glycerin in canine experimental palat cleft

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    Emerson Antônio Contesini

    2003-02-01

    Full Text Available Os defeitos de espessura completa do palato que resultam em comunicação oro-nasal raramente cicatrizam espontaneamente. Eles requerem reparo cirúrgico, porém, pode ser difícil obter cicatrização satisfatória devido às condições próprias das cavidades nasal e oral. Neste experimento, foram utilizados 14 cães, reunidos em dois grupos de igual número. Todos animais foram submetidos à indução de fenda palatina experimental. O grupo G1 foi o controle, cuja palatoplastia foi realizada a partir da confecção de "flap" muco-periósteo. No grupo G2, foi utilizada cartilagem da pina auricular conservada em glicerina a 98% entre o osso palatino e o muco-periósteo. Os animais foram avaliados macroscopicamente quanto ao processo cicatricial, por radiografias para a regeneração óssea e por rinoscopia para observar a regeneração da mucosa nasal. Foi observada a cicatrização da mucosa oral a partir do 10º dia, com deiscência de sutura em dois animais do grupo G1. A radiografia demonstrou evolução na cicatrização óssea, num processo mais acelerado no grupo G2 quando comparado ao grupo G1. A rinoscopia revelou, aos 60 dias, completa regeneração da mucosa nasal em ambos os grupos. Ao final do período de avaliação foi observada macroscopicamente, completa fusão óssea nos animais do grupo G2 e incompleta nos do grupo G1, o que demonstrou a interferência benéfica do implante no processo cicatricial do grupo G2.The incomplete defects of hard palate result in oro-nasal fistula seldom cure themselves in a spontaneous way, due to limited condition in oral and nasal cavity it may be difficult to obtain satisfactory cicatrization, requiring surgery to interfere in the healing process. Fourteen dogs arranged in two groups were submitted to experimental hard palate cleft. The G1 group was the control group, in which palatoplasty was achieved with mucous-periosteum flap. In the G2 group, a preserved at 98% glycerin auricular pinna

  4. Regeneração hepática induzida por ressecção segmentar do fígado, em rato Hepatic regeneration induced by segmental liver resection, in rats

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    Andy Petroianu

    2004-02-01

    Full Text Available OBJETIVO: Avaliar a regeneração progressiva do parênquima hepatocitário, nos seus aspectos macro e microscópicos, em pós-operatório imediato e tardio de ressecção segmentar do fígado. MÉTODO: Foram estudados 10 ratos machos albinos da raça Wistar, pesando entre 250 e 300 gramas, submetidos à hepatectomia parcial de lobo esquerdo, com retirada de cerca de 20% da massa total do órgão. Os animais foram divididos aleatoriamente em dois grupos (n=5 para estudo no 7º (Grupo 1 e 21º (Grupo 2 dias pós-operatórios. Decorrido o tempo de acompanhamento, avaliou-se o aspecto macroscópico e microscópico do fígado. RESULTADOS: No Grupo 1, após sete dias, os animais apresentavam a cavidade abdominal com poucas aderências. O fígado mostrava reação cicatricial no local da ressecção, porém seu tamanho já era próximo ao normal. O exame histopatológico mostrou freqüentes sinais de poliploidia dos hepatócitos, além de tecido de granulação frouxo e desordenado, acompanhado de escasso infiltrado de células inflamatórias. O Grupo 2, após 21 dias, mostrava poucas aderências na cavidade abdominal, e o fígado com aspecto e dimensões próximos ao normal. A histologia mostrou tecido cicatricial mais denso, ordenado, sem sinais inflamatórios. Observou-se apenas pequeno grau de poliploidia hepatocitária. CONCLUSÃO: Após remoção cirúrgica de 20% do parênquima hepático houve aumento temporário da renovação celular verificado por poliploidia hepatocitária.BACKGROUND: To assess the progression of liver regeneration after partial hepatic resection. METHODS: Ten Wistar adult rats, of both sexes were studied. After anesthesia with ether, the animals were submitted to a left lobe parcial hepatectomy . Rats were randomly divided into two groups (n=5 according to the day macro and microscopic studies were carried out, 7th (Group 1 or 21st postoperative days. RESULTS: All rats survived throughout the experimental protocol. The

  5. EFFECTS OF ELECTRIC STIMULATION ON THE HEALING OF TENDON OF THE GASTROCNEMIUS MUSCLE IN RABBITS (Oryctolagus cunicullus EFEITOS DA ESTIMULAÇÃO ELÉTRICA NA CICATRIZAÇÃO DO TENDÃO DO MÚSCULO GASTROCNÊMIO EM COELHOS (Oryctolagus cunicullus

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    Weslay Souza de Oliveira

    2009-09-01

    Full Text Available The aim of this study was to evaluate the effect of transcutaneous electrical stimulation with alternate electrical current on gastrocnemius muscle tendon healing, in rabbits submitted to experimental tenotomy and tenorrhaphy. Twenty-four male rabbits, New Zealand breed, were divided into four groups of the same number, in order to evaluate the cicatricial tendon repair at 7, 15, 21 and 30 days post-surgery. The middle third of the tendon of the gastocnemius muscle was sectioned transversall and submitted to a synthesis with Kessler modified suture. After 24 hours, daily at the same schedule, were done near the cutaneous wound of the right pelvic member, applications of 2 mA of alternative current, during six minutes, at a frequence of 100 Hz. The material collected was examined by light microscopy. Significant difference wasn´t found between the treated member and the control. Transcutaneous electrotherapy was used in our experimental protocol, despite not leading to tissue damage and being less invasive in comparison to other methods, was incapable to promote a more efficient healing response on the gastrocnemius muscle tendon repair in rabbits.

    KEY WORDS: Achilles tendon, electrotherapy, surgery, tenotomy, tissue repair. Este trabalho teve como objetivo avaliar o efeito da estimulação elétrica transcutânea de corrente alternada na regeneração do tendão do músculo gastrocnêmio, em coelhos submetidos à tenotomia e tenorrafia experimental. Dividiram-se vinte e quatro coelhos adultos da raça Nova Zelândia em quatro grupos iguais para avaliação da cicatrização tendínea aos sete, quinze, vinte e um e trinta dias de pós-operatório. Após incisão cutânea de aproximadamente três centímetros, o terço médio do tendão do músculo gastrocnêmio foi individualizado, seccionado transversalmente e suturado com sutura de Kessler modificada. Decorridas 24 horas, diariamente em um mesmo horário aplicaram-se, próxima

  6. EFEITOS DO AGAROLâ E DO TRIGLICERILâ SOBRE A CICATRIZAÇÃO DE PELE: ESTUDO EXPERIMENTAL EM RATOS

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    Celso Fernando Ribeiro Araújo

    1998-10-01

    Full Text Available Desde os mais remotos tempos pesquisam-se incessantemente drogas que acelerem o processo cicatricial normal. No Hospital de Clínicas da UFPr preconiza-se a limpeza de feridas limpas com solução salina de NaCl a 0,9%. Alguns serviços têm utilizado empiricamente o Agarol® e o Trigliceril® na confecção do curativo após este procedimento. Este estudo objetivou avaliar experimentalmente a evolução de feridas cutâneas, em ratos, produzidas por incisão cirúrgica tratadas com solução de NaCl a 0,9%, Agarol® e Trigliceril® . Utilizou-se 24 ratos, divididos em três grupos: C, controle, submetido à troca diária de curativo após limpeza com solução de NaCl a 0,9%; grupo A com aplicação de Agarol® e grupo T com aplicação de Trigliceril®. Verificou-se que no terceiro e décimo quarto dias de pós-operatório o Agarolâ e o Triglicerilâ não influenciaram o processo cicatricial. No sétimo dia de pós-operatório verificou-se houve aumento da quantidade de tecido de granulação nos grupos tratados com Agarolâ e diminuição da neovascularização no grupo Triglicerilâ .For centuries, mankind has been incessantly researching with drugs that could accelerate the normal wound healing process. In the Hospital de Clinicas da Universidade Federal do Paraná, it has been recommended that the cleansing of clean wounds with saline solution of 0.9% sodium chloride, followed by a cover of dry dressing. However, some services have empirically used Agarol and Trigliceril in the confection of dressings after cleansing. This study aimed to evaluate the evolution of cutaneous wounds treated with normal saline, Agarol and Trigliceril in rats. A group of twenty-four rats were submitted to three skin circular incisions of 1.2 cm in diameter on their backs which exposed the subcutaneous tissue. The wounds were cleaned daily with normal saline solution. This group was distributed at random within three groups: Group C, control, received a clean

  7. Reparación quirúrgica de fístula traqueocutánea y de cicatriz postraqueotomía mediante colgajo dermograso de rotación Reparação cirúrgica de fístula traqueocutânea e de cicatriz pós-traqueostomia com rotação de retalho dermoadiposo Surgical repair of tracheocutaneous fistulae and postracheotomy scar using a dermoadipose turn-over flap

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    F. Passos da Rocha

    2009-03-01

    Full Text Available La fístula traqueocutánea y la retracción cicatricial son las complicaciones postraqueotomía más frecuentes. El objetivo del presente trabajo es el presentar una técnica quirúrgica de fácil ejecución para la reparación de los defectos estéticos y funcionales creados por estas patologías. Presentamos el caso de un varón de 61 años que había sufrido traqueotomía. Tras la decanulación, la cicatrización cursó con retracción, adherencia a planos profundos y aparición de fístula traqueocutánea. El cierre de la fístula se hizo reparando el defecto funcional mediante la técnica de rotación de colgajos dermograsos en "hoja de libro", logrando el cierre del área de retracción y reparando el defecto estético. La retracción cutáneo-hipodérmica es un defecto inestético, incómodo y estigmatizante. Las fístulas traqueocutáneas con escape de aire son desagradables tanto desde el punto de vista funcional como estético. El método que presentamos logró corregir la fístula y la depresión provocada por la traqueotomía mediante un procedimiento simple, rápido y efectivo. Este método evita las dificultades encontradas en otras técnicas y garantiza la corrección funcional y estética empleando un método simple con baja morbilidad.Tracheocutaneous fistulas and scar retraction are frequent complications of the tracheotomy. The objective of the present manuscript is to present an easy execution surgical technique to restore tracheocutaneous fistula and cutaneous retraction. We present the clinical case of a 61 years old man who had suffered tracheotomy. After decannulation, the scar became retracted and adhered to deep tissues, developing into a tracheocutaneous fistula. The fistula was closed repairing the functional defect and a turn-over hinge flap of dermoadipose tissue was used to fill the retracted area, correcting the aesthetic abnormality. Correction of cicatricial retraction and of tracheocutaneous fistula using the

  8. Anastomoses colônicas após mucosectomia química, em ratos Colonic anastomosis after chemical mucosectomy in rats

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    Ivana Duval-Araujo

    2009-03-01

    macroscopic aspect (adherence, fistula, stenosis, perianastomotic abscesses, peritonitis, rupture pressure (mmHg and histology (inflammatory infiltrate. The data were analysed by Chi-square test (qualitative data and ANOVA (quantitative data, and considered significative values of p<0.05. RESULTS: None animal presented fistula. The incidence of adherence was no different among the groups. (A1=100%, B1=100%, p= NS; A2=75%, B2=50%, p= NS. There were anastomosis partial obstruction in 25% of group A1, 50% in B1, 25% in A2 and 50% in B2, without significant differences among the groups. The rupture pressure was 27,0 ± 4,5 in A1 group, 34,5 ± 2,0 in B1 group, 28,9 ± 4,2 in A2 group and 24,0 ± 3,4 in group. There was an significant increase in pressure rupture in B1 group when compared with A1 group (p=0,03 and B2 group (p=0,02. CONCLUSION: The chemical mucosectomy with silver nitrate was not associated with increase in postoperative cicatricial complications in wound colon healing in rats. There was, however, an increase in anastomosis strength in early period of the cicatricial process, without influence in latter period.

  9. Cicatrização de feridas Wound healing

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    Antonio Carlos Ligocki Campos

    2007-03-01

    Full Text Available INTRODUÇÃO: A cicatrização de feridas consiste em perfeita e coordenada cascata de eventos que culminam com a reconstituição tecidual. O processo cicatricial é comum a todas as feridas, independe do agente que a causou. O processo de cicatrização é dividido didaticamente em três fases: inflamatória, proliferação ou granulação e remodelamento ou maturação. O colágeno é a proteína mais abundante no corpo humano e também é o principal componente da matriz extracelular dos tecidos. Estrutura-se numa rede densa e dinâmica resultante da sua constante deposição e reabsorção. O tecido cicatricial é resultado da interação entre sua síntese, fixação e degradação. Existem várias maneiras de avaliar a cicatrização das feridas. Os métodos mais utilizados atualmente são a tensiometria, a densitometria e morfometria do colágeno, a imunoistoquímica e, mais recentemente, a dosagem de fatores de crescimento. MÉTODOS: Foram revisadas todas as dissertações de mestrado e teses de doutorado realizadas na linha de pesquisa "Cicatrização de órgãos e tecidos" do programa de Pós-Graduação em Clínica Cirúrgica da Universidade Federal do Paraná. Foi realizada, também, revisão atualizada da literatura internacional no Pubmed e nacional. CONCLUSÃO: A cicatrização é um processo complexo, que começou a ser entendido em maior amplitude nos últimos anos. Recentes pesquisas têm sido direcionadas para atuar na modulação da cicatrização a nível molecular, na tentativa de evitar completamente cicatrizes patológicas.BACKGROUND: The wound healing consists of a perfect and coordinated cascade of events that result in tissue reconstitution. The healing process is common to all wounds, independently of the agent that has caused it. It is divided didactically into three phases: inflammation, proliferation or granulation and remodelation or maturation. The collagen is the most abundant protein in the human body and is

  10. Effects of topical 2% cyclosporine A on the corneas of dogs subjected to lamellar keratoplasty with a graft of equine pericardium preserved in glycerin: clinical and morphological evaluation Efeitos da aplicação tópica da ciclosporina A a 2% sobre a córnea de cães submetidos à ceratoplastia lamelar com implante de pericárdio de eqüino preservado em glicerina: avaliação clínica e morfológica

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    Roseli Borges Teixeira

    2004-02-01

    Full Text Available The effects of topical 2% cyclosporine A on the cornea of dogs subjected to experimental lamellar keratoplasty with an equine pericardial graft were evaluated. Ten dogs were grouped to be evaluated 3, 7, 15, 30 and 60 days after surgery. Animals received bilateral grafts followed by the application of a 2% cyclosporine A ointment on the left eye (treated eye and the ointment base on the right eye (control eye twice a day. The ophthalmic evaluation showed profound bilateral blepharospasm, photophobia and a mucous secretion until the 7th day after surgery; corneal vascularization starting in the limbus was observed as early as the 3rd day in both eyes; opacification and vascularization were more intense in the treated cornea on days 15 and 30 after surgery. Vascularization was still evident on the 60th day, and looked similar in treated eyes and control eyes. The histologic evaluation showed a complete bilateral reepithelization and corneal vascularization three days after the surgery; intense vascularization in both eyes on days 15 and 30, that was much more pronounced in the treated cornea; and a bilateral predominance of polymorphonuclear cells until day 15, and mononuclear cells on day 30. Intact epithelium and stroma with new vessels, as well as graft absorption, in both eyes, were seen on the 60th day. The lamellar keratoplasty with equine pericardial graft was an effective model to study the inflammatory kinetics and corneal vascularization phenomenon. In this study, cyclosporine A did not inhibit corneal vascularization and it did not interfere in the corneal cicatricial process.Foram avaliados os efeitos da ciclosporina A a 2% sobre a córnea de cães submetidos à ceratoplastia lamelar experimental com implante de pericárdio de equino. Dez cães foram divididos em grupos para estudo aos três, sete, 15, 30 e 60 dias de pós-operatório, recebendo implantes bilaterais e em seguida aplicação da pomada com ciclosporina A a 2% no olho

  11. Efeitos da terapia física descongestiva na cicatrização de úlceras venosas Efectos de la terapia física descongestiva en la cicatrización de úlceras venosas Effects of the decongestive physiotherapy in the healing of venous ulcers

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    Roberta Azoubel

    2010-12-01

    Full Text Available Objetivou-se neste estudo verificar os efeitos da terapia física descongestiva (TFD na cicatrização de úlceras venosas. Trata-se de um estudo intervencionista, quase experimental, do qual participaram 20 clientes, divididos em 2 grupos: o grupo controle (n=10 e o grupo de intervenção (n=10. Os clientes do primeiro grupo foram tratados apenas com curativo convencional e os do segundo grupo, com curativo convencional e terapia física descongestiva (associação de técnicas: drenagem linfática manual, enfaixamento compressivo, elevação dos membros inferiores, exercícios miolinfocinéticos e cuidados com a pele. Ambos os grupos foram tratados durante seis meses. Os clientes submetidos à TFD apresentaram significante redução de edema e da dor, além de melhora no processo cicatricial. Os resultados permitiram verificar que a terapia descongestiva estimula o processo de cicatrização de úlceras venosas, melhorando a qualidade de vida dos indivíduos.En este estudio se objetivó verificar los efectos de la terapia física descongestiva (TFD en la cicatrización de úlceras venosas. Se trató de un estudio intervencionista, casi experimental, del cual participaron veinte pacientes que constituyeron dos grupos: el grupo control (n=10 y el grupo de intervención (n=10. Los pacientes del primer grupo fueron tratados apenas con curaciones convencionales, mientras que los del segundo grupo recibieron curación convencional y terapia física descongestiva (asociación de técnicas: drenaje linfático manual, fajamiento compresivo, elevación de los miembros inferiores, ejercicios miolinfocinéticos y cuidados con la piel. Ambos grupos fueron tratados durante seis meses. Los pacientes sometidos a TFD presentaron significativa reducción de edema y dolor, y mejora en el proceso cicatricial. Los resultados permitieron verificar que la terapia descongestiva estimula el proceso de cicatrización de úlceras venosas, mejorando la calidad de vida de

  12. Histopathology of human American cutaneous leishmaniasis before and after treatment Histopatologia de leishmaniose tegumentar americana humana, antes e após o tratamento

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    A.C.C. Botelho

    1998-02-01

    Full Text Available Chemical therapy for the treatment of leishmaniasis is still inadequate, and a number of drugs and therapeutic programs are being tested. Besides treatment, the ultimate goal is an effective cure, and histopathological analyses of the lesion cicatrices constitute an important measure of treatment success, or otherwise, in this respect. In this paper, we describe histopathological patterns in cases of American cutaneous leishmaniasis in 32 patients from the municipality of Caratinga, Minas Gerais, Brazil, before and after treatment with the following therapeutic methodos: l leishvacin + glucantime; 2 leishvacin + BCG associated with glucantime; 3 glucantime; 4 leishvacin + BCG. Lesion fragments were collected from all patients by biopsy prior to, and approximately 30 days after, each treatment which resulted in a clinical diagnosis of cure. Following the analysis of slides, the preparations were described from a histopathological point of view and grouped taking into account the prevalence or significance of the characteristic elements. This process resulted in the following classification: 1. exsudative reaction (ER; 2. exsudative giant cell reaction (EGCR; 3. exsudative productive reaction (EPR; 4. exsudative productive giant cell reaction (EPGCR; 5. exsudative productive necrotic reaction (EPNR; 6. necrotic exsudative reaction (NER; 7. productive exsudative reaction (PER, 8. productive giant cell reaction (PGCR; 9. productive exsudative giant cell reaction (PEGCR; 10. productive exsudative giant cell granulomatous reaction (PEGCGR; 11. productive reaction (PR and 12. productive cicatricial (cure reaction (PCR. After this analysis, it was noted that clinical cure did not always coincide with histopathological cure.A quimioterapia para a leishmaniose não é satisfatória e existem hoje, várias drogas e esquemas terapêuticos em teste. Além do tratamento ideal, busca-se um critério de cura efetivo, onde a análise da histopatologia da

  13. Evaluation of the abdominal wall cicatrization of rabbits exposed to nicotine and undergone abdominoplasty using nylon thread or cyanoacrylate Avaliação da cicatrização da parede abdominal de coelhos expostos à nicotina e submetidos à abdominoplastia, utilizando-se nylon ou cianocrilato

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    Luciano Assis Costa

    2012-12-01

    Full Text Available PURPOSE: To compare the wound healing of the abdominal wall of rabbits exposed to nicotine and submitted to abdominoplasty using 2-octyl cyanoacrylate or nylon thread for the surgery suture. METHODS: Thirty two rabbits were used. They were divided in subgroups: A1, A2, B1 e B2. Group A received saline 0.9%; group B received nicotine, both groups for 14 days before surgery. We performed an abdominoplasty with a nylon suture into the A1 and B1 subgroups; as for A2 and B2 groups the suture was performed with cyanoacrylate. The euthanasia happened in the 14th post-operative day. After, we evaluated: swollen process, fibroblast proliferation, collagen, neovascularization, and macroscope and microscope epithelization of the scars. RESULTS: We observed the presence of eosinophils in all scars exposed to the cyanoacrylate, and a significant increase of neovascularization in the subgroup B2 comparing to the A2 one (p=0.037. The other variables haven't showed any statistical difference. CONCLUSIONS: Nicotine hasn't influenced the swollen process, the fibroblast proliferation, the presence of collagen, neither the epithelialization. The neovascularization showed cicatricial immaturity when comparing group A2 to group B2. The eosinophils in the scars repaired with glue showed that the substance has acted as an allergen.OBJETIVO: Comparar a cicatrização da parede abdominal de coelhos expostos à nicotina e submetidos à abdominoplastia utilizando 2-octil cianoacrilato ou nylon na síntese cirúrgica. MÉTODOS: Utilizou-se 32 coelhos. Estes foram distribuídos em subgrupos: A1, A2, B1 e B2. O grupo A recebeu solução de NaCl 0,9%; o B recebeu nicotina, ambos durante 14 dias do pré-operatório. Nos subgrupos A1 e B1 foi realizada abdominoplastia e sutura com "nylon"; enquanto A2 e B2 a síntese ocorreu com cianoacrilato. A eutanásia ocorreu no 14º dia do pós-operatório. Na pesquisa avaliou-se: processo inflamatório, proliferação fibroblástica, col

  14. Queilite actínica: avaliação comparativa estética e funcional entre as vermelhectomias clássica e em W-plastia Actinic cheilitis: aesthetic and functional comparative evaluation of vermilionectomy using the classic and W-plasty techniques

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    Ed Wilson Tsuneo Rossoe

    2011-02-01

    Full Text Available FUNDAMENTO: A queilite actínica crônica é a ceratose actínica localizada no vermelhão labial. O tratamento é de crucial importância, devido ao potencial de transformação maligna. OBJETIVO: Avaliar os resultados estéticos e funcionais das vermelhectomias clássica e em W-plastia na queilite actínica. Na técnica clássica, a cicatriz é linear; na W-plastia, em linha quebrada. MÉTODOS: Foram tratados 32 pacientes com diagnóstico clínico e histopatológico de queilite actínica. Quinze deles foram submetidos à técnica em W-plastia e 17, à técnica clássica. Avaliaram-se parâmetros como retração cicatricial e alterações funcionais. RESULTADOS: Houve associação estatisticamente significativa entre a técnica utilizada e a presença de retração cicatricial, sendo a associação positiva com a clássica (p=0,01 com correção de Yates. O risco relativo (odds ratio - OR calculado foi de 11,25, ou seja, houve maior chance de retração nos pacientes submetidos à técnica clássica. Nenhuma das técnicas apresentou alterações funcionais. Avaliaram-se complicações pós-operatórias como presença de crostas, lábios secos, parestesia e deiscência de sutura. Não houve associação estatisticamente significante entre as complicações e a técnica utilizada (p=0,69. CONCLUSÃO: Concluiu-se que a vermelhectomia em W-plastia oferece melhores resultados estéticos e índices de complicações semelhantes.BACKGROUND: Chronic actinic cheilitis is actinic keratosis located on the vermilion border. Treatment is essential because of the potential for malignant transformation. OBJECTIVE: To evaluate the aesthetic and functional results of vermilionectomy using the classic and Wplasty techniques in actinic cheilitis. In the classic technique, the scar is linear and in the W-plasty one, it is a broken line. METHODS: 32 patients with clinical and histopathological diagnosis of actinic cheilitis were treated. Out of the 32 patients, 15

  15. Management of delayed intrathoracic esophageal perforation with modified intraluminal esophageal stent.

    Science.gov (United States)

    Zhou, J-H; Gong, T-Q; Jiang, Y-G; Wang, R-W; Zhao, Y-P; Tan, Q-Y; Ma, Z; Lin, Y-D; Deng, B

    2009-01-01

    In this article, we reviewed our experience of treatment of the delayed intrathoracic nonmalignant esophageal perforation employing modified intraluminal esophageal stent. Between February 1990 and August 2006, eight patients were included in this study. Five patients experienced sepsis. The interval time between perforation and stent placement ranged from 36 h to 27 days (average, 8.6 days). Esophageal stenting and throracotomy for foreign body removal were performed in four patients. The remaining four patients underwent stent placement and thoracostomy. Nutrition was initiated through gastrostomy after 7 to 10 days after the stenting. The stent was removed after the patients resumed oral intake of food and the esophagogram showed that perforation was closed. There was no death in this group. Signs of sepsis remitted 1 week after stent placement. Complications included stress ulcer, stimulative cough, and pneumonia each. Stent removal ranged 32 to 120 days (average 66.7) after its placement. The stent was kept in place for 4 months to prevent formation of esophageal stricture in one patient with caustic esophageal burns. The follow-up was completed in all the patients. The mean follow-up period was 59 months (range 12-180). One patient with caustic esophageal burn underwent cicatricial esophagectomy and gastric transposition 3 years later due to the esophageal stricture. Barium swallow demonstrated that there was a diverticulum-like outpouching in one patient and slight esophageal stricture at T2 and T3 level in another. One patient developed reflux esophagitis 5 years after stent removal. All the patients finally had a normal intake of food. Modified esophageal stenting is an effective method to manage the delayed intrathoracic esophageal perforation. Prevention of stent migration and its convenient adjustment might be the major advantages of this method. PMID:19191858

  16. A split mouth randomized controlled study to evaluate the adjunctive effect of platelet-rich fibrin to coronally advanced flap in Miller′s class-I and II recession defects

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    Rajan Padma

    2013-01-01

    Full Text Available Background: There are various techniques developed to treat the exposed roots, a recent innovation in dentistry is the use of second generation platelet concentrate which is an autologous platelet-rich fibrin gel (PRF with growth factors and cicatricial properties for root coverage procedures. Therefore, the present research was undertaken to study the additional benefits of PRF when used along with coronally advanced flap (CAF. Materials and Methods: Total of 15 systemically healthy subjects presenting bilateral isolated Miller′s class I and II recession were enrolled into the study. Each patient was randomly treated with a combination of CAF along with a platelet-rich fibrin (PRF membrane on the test site and CAF alone on the control site. Recession depth, clinical attachment level (CAL, and width of keratinized gingiva (WKG were compared with baseline at 1, 3, and 6 months between test and control sites. Results: Mean percentage root coverage in the test group after 1, 3, and 6 months was 34.58, 70.73, and 100, respectively. Differences between the control and test groups were statistically significant. This study also showed a statistically significant increase in WKG in the test group (2.94 ± 0.77 at baseline to 5.38 ± 1.67 at 6 months. Conclusion: CAF is a predictable treatment for isolated Miller′s class I and II recession defects. The addition of PRF membrane with CAF provides superior root coverage with additional benefits of gain in CAL and WKG at 6 months postoperatively.

  17. Influência da vitamina C e da hidrocortisona sobre a tensão anastomótica jejunal em ratos

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    Petroianu Andy

    2000-01-01

    Full Text Available O efeito da vitamina C e da hidrocortisona sobre os processos cicatriciais anastomóticos apresenta resultados conflitantes na literatura. Dessa forma, o presente trabalho teve o objetivo de comparar a resistência cicatricial de anastomoses jejunais em ratos, submetidos à administração de vitamina C e de hidrocortisona, em distintos períodos pós-operatórios. Foram estudados 40 ratos Wistar, submetidos a secção e subseqüente anastomose término-terminal de segmento jejunal, a 10 cm da flexura duodenojejunal. Os animais foram divididos em quatro grupos (n=10: Grupo I - controle; Grupo II - administração de vitamina C oral 100 mg/kg; Grupo III - administração de hidrocortisona intraperitoneal 10 mg/kg; Grupo IV - administração de vitamina C mais hidrocortisona nas doses e vias de administração acima. Avaliaram-se as pressões de ruptura anastomótica nos 5 º e 21º dias pós-operatórios. Os ratos que receberam vitamina C isolada ou associada a hidrocortisona tenderam a uma pressão de ruptura maior do que os demais grupos, tanto no 5º quanto no 21º dias pós-operatórios. Os resultados deste trabalho sugerem que a vitamina C contribui para aumentar a resistência das anastomoses jejunais dos ratos durante os primeiros 5 dias pós-operatórios. A resistência das anastomoses jejunais murinas foi pouco influenciada pela administração de corticóide intraperitoneal.

  18. Outcomes with the Boston Type 1 Keratoprosthesis at Instituto de Microcirugía Ocular IMO

    Science.gov (United States)

    Güell, Jose L.; Arcos, Edilio; Gris, Oscar; Aristizabal, Diego; Pacheco, Miguel; Sanchez, Claudia L.; Manero, Felicidad

    2011-01-01

    Purpose To report the outcomes on the Boston Type 1 Keratoprosthesis at our institution. Design Retrospective analysis case series. Participants We analyzed 54 eyes of 53 patients who previously underwent Boston Type 1 Keratoprosthesis surgery at our institution from July 2006 to March 2011. Methods Preoperative and postoperative parameters were collected and analyzed. Main outcome measures Visual acuity and keratoprosthesis stability. Results Common preoperative diagnoses were penetrating keratoplasty failure in 49 eyes (90.7%), chronic keratitis in 2 eyes (3.7%), ocular cicatricial pemphigoid in 1 eye (1.85%), Stevens Johnson syndrome in 1 eye (1.85%) and corneal vascularization in 1 eye (1.85%). Additionally, 40 eyes (74%) had preoperative glaucoma, and an Ahmed valve was implanted in 55% of them. Preoperative BCVA ranged from 20/200 to light perception. At an average follow-up of 20.15 months ± 12.7 (range, 1–56), postoperative vision improved to ⩾20/200 in 18 eyes (33.3%) and ⩾20/50 in 4 eyes (7.4%). The graft retention was 96%. Conclusions The Boston Type 1 keratoprosthesis is a valid option for high-risk patients. The design improvements in the Boston keratoprosthesis, as well as the daily implementation of the therapeutic methods, have notably diminished occurrence of the most serious complications, such as corneal necrosis and endophthalmitis. As such, glaucoma and its subsequent complications now stand as the most prevalent prognostic factor in the long term. PMID:23960937

  19. Uso de concentrados autólogos de plaquetas como terapia regenerativa de enfermedades crónicas del aparato musculoesquelético equino Use of autologous platelet concentrates as regenerative therapy for chronic diseases of the equine musculoskeletal system

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    JU Carmona

    2011-01-01

    Full Text Available Las plaquetas son fundamentales para la reparación tisular de las heridas, ya que secretan factores de crecimiento, los cuales inducen quimiotaxis, proliferación y diferenciación celular, neovascularización y producción de la matriz extracelular. Se ha propuesto el uso de concentrados autólogos de plaquetas (APCs para acelerar la cicatrización de heridas, disminuir la inflamación, estimular la capacidad regenerativa de los tejidos lesionados, disminuir la actividad fibroblástica y la producción de tejido cicatricial no-funcional. Los APCs pueden ser preparados mediante diferentes métodos. Cada método produce APCs de diferente calidad celular y molecular. Recientemente, se ha generado información básica y clínica que justifica el uso de APCs en caballos con enfermedades degenerativas del aparato musculoesquelético equino como la osteoartritis, tendinopatías y desmopatías.Platelets are of pivotal importance for wound healing since they release growth factors that in turns produce chemotaxis, both cellular proliferation and differentiation, angiogenesis, and extracellular matrix deposition. The use of autologous platelet concentrates (APCs has been proposed for accelerating wound healing, decreasing inflammation, to stimulate the regenerative capability of the injured tissues, to decrease the fibroblastic activity and to avoid the production of non functional scarring tissue. APCs could be obtained by several methods. Each method produces APCs of different both cellular and molecular quality. Recently, some basic and clinical information that justifies the usage of APCs for the treatment of degenerative musculoskeletal diseases in horses, such as osteoarthritis, tendinopathies and desmopathies has been published.

  20. Bullous disorders in Konya: A study of 93 cases

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    Munise Daye

    2013-12-01

    Full Text Available Background and Design: Bullous disorders are a group of disorders caused by specific antibodies against tissue adhesion molecules in skin and mucosa or genetic inheritance. There are limited detailed epidemiological studies about bullous disorders in Turkey. In this study we evaluated the demographic, clinical, immunopathologic, course and follow-up properties, cases in Konya. Most of cases were in pemphigus and bullous pemphigoid group, so we gave more information about them. Materials and Methods: Ninty three cases that are followed up during the period of 2006-2012 were included in our study. Results: Female cases were %53,8, male cases were %46,2. The mean age was 52,9. In all of cases; %37,6 cases were pemhigus vulgaris, % 34,4 bullous pemphigoid, %15 herediter epidermolysis bullosa, %4,3 were dermatitis herpetiformis, %4,3 were pemphigus foliaceus, %2,2 pemphigus vegetans, %1,1 Hailey- Hailey disease, %1,1 cicatricial pemphigoid. Mean age of Pemhigus vulgaris onset was 45,9 year and mostly it was observed in females. Pemhigus vulgaris has been started at oral mucosae and the time for diagnosis of pemhigus vulgaris, which began at oral mucosae, was longer than other geogrophic regions. Mean age bullous pemphigoid onset was 70 year and mostly it was observed in females. In % 12,5 of cases disease started at oral mucosae. None of the cases had additional autoimmune disorder. We have treated 25 cases with systemic corticosteriods, 41 cases with systemic corticosteriods and adjuvan agents, 11 cases with only one of adjuvan agents, 16 cases with only local streoids. Conclusions: We report the demographic, clinical, immunopathologic, course and follow-up properties of the bullous disorders in Konya.

  1. Interferón alfa-2b tópico como primera opción en las neoplasias intraepiteliales corneoconjuntivales Topical interferon alfa-2b for primary treatment of conjunctiva-cornea intraepithelial neoplasia

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    M. Pérez de Arcelus

    2012-04-01

    Full Text Available Se describen dos casos de neoplasia intraepitlelial corneo-conjuntival (CIN tratados con interferón alfa-2b (IFN alfa-2b tópico como primera elección. El tratamiento clásico de los CIN ha sido tradicionalmente la resección completa con márgenes de seguridad seguida de crioterapia en el lecho quirúrgico. No obstante, y puesto que la tasa de recidivas puede alcanzar el 50% han sido propuestos coadyuvantes como la mitomicina C y el 5 fluoracilo, con el consiguiente riesgo de toxicidad corneal y límbica. El IFN alfa-2b presenta una eficacia similar a la cirugía en la erradicación completa de la masa tumoral como primera opción, con escasos efectos secundarios y nulo potencial carcinogénico, incluso en casos de recurrencia a terapia con mitomicina C, lesiones quirúrgicas residuales y formas difusas.We describe two cases of conjunctival-cornea intraepithelial neoplasia (CIN, treated with topical IFN alfa 2b. The traditional treatment for CIN is surgical excision usually with adjunctive cryotherapy. However, residual tumour may remain, which can lead to recurrence rates of more than 50%. 5-Fluorouracil, mitomicyn C and interferon alfa 2b are new pharmacological agents that have proved their efficacy in the treatment of CIN. As side effects are common, we present IFN alfa 2b as a single therapeutic agent as an effective and optimal treatment for presumed recurrent corneal and conjunctival intraepithelial neoplasia. It offers the benefits of topical therapy and avoids the risks of surgical or other interventions - specifically, ocular surface toxicity, cicatricial conjunctival changes, and limbal stem cell deficiency.

  2. CT findings of mucoid impaction in 13 case: Speculation on their etiology

    International Nuclear Information System (INIS)

    Mucoid impaction presents a typical appearance on plain radiography and CT. If the lesion is multiple with manifestations of diffuse bronchopathy, it usually is a medical disease. On the other hand, if the lesion is single, an effort should be made to determine the underlying disease. The most frequent cause of the latter lesion is lung cancer, which generally can be depicted by CT. We retrospectively reviewed 13 cases of chest CT with obstructive mucoid impaction, in which CT and BFS(bronchofiberscopy) did not reveal a specific underlying cause. Women in the twenties and thirties were dominant and a past history of pulmonary tuberculosis was present in nine, BFS, done in nine, showed bronchial obstruction, and also luminal narrowing and cicatricial mucosal changes proximal to the obstruction in all them. Endobronchial tuberculosis was proven in only one case by bronchial wall biopsy. Lobectomy was performed in three. At the bronchial obstruction site, thickened bronchial walls were connected to proximal bronchi and there was no evidence of a clear underlying pathology except submucosal fibrosis in all three. The level of bronchial obstruction , determined by CT and BFS, was in the main bronchus in one, lobar bronchi in six, and divisional or segmental bronchi in seven, CT additionally showed calcific spots in their parenchyma connected to the bronchial obstruction in seven cases, and other changes suggestive of tuberculous origin in eight patients. In the context of the clinical history, BFS results, CT findings and pathologic findings of surgical specimen, most, if not all, of these 13 lesions are supported to be a sequela of endobronchial tuberculosis

  3. Retinopathies in premature infants, incidence, risk factors, prevention and treatment

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    Chernenkov Yu.V.

    2014-12-01

    Full Text Available Research Objective: Analysis of incidence and accompanying states, detection of risk factors of retinopathies in premature infants (RN, dynamic monitoring and improvement of medical actions. Material and Methods: 134 children have been surveyed in the group of risk on development of RN for the last 2 years. Results: From 134 surveyed infants with gestation from 22 to 37 weeks and body weight at birth from 750 to 2500 kg. At 56 children (41,8% the retinopathy of various degree of expressiveness has been revealed. 38 children with RN of 1-2 stages (67,8% from which at 22 (39,3% —the disease ended with the induced regress after a course of «retinalamin», at 16 (28,6% of RN — spontaneous regress. 4 children (7,1% had RN 2-3 of the Art., 3-4 Art. at 12 (21,4%, and 5 Art. a cicatricial phase with retinal detachment — 2 (3,5%. In 12 cases the laser photocoagulation in the eye centers is carried out. Conclusion: The revealed relationship of cause and effect of risk factors of formation of RN with features of a current ofthe neonatal period at patients with RN, promoted development of the system of monitoring, implementation of the program of treatment and rehabilitation of prematurely born children suffering RN. Ophthalmologic screening of premature infants with the use of the ophthalmologic digital pediatric camera "Ret Cam 3" allows to diagnose a retinopathy at early stages, in due time to hold preventive an3 medical measures that allows to lower the invalidization of this group of children.

  4. The practical usefulness of dermoscopy in general dermatology.

    Science.gov (United States)

    Errichetti, E; Stinco, G

    2015-10-01

    vasculitis and common inflammatory cicatricial alopecia (discoid lupus erythematosus, lichen planopilaris and folliculitis decalvans). PMID:26086412

  5. Endoscopic management of esophageal stenosis in children: New and traditional treatments.

    Science.gov (United States)

    Dall'Oglio, Luigi; Caldaro, Tamara; Foschia, Francesca; Faraci, Simona; Federici di Abriola, Giovanni; Rea, Francesca; Romeo, Erminia; Torroni, Filippo; Angelino, Giulia; De Angelis, Paola

    2016-02-25

    Post-esophageal atresia anastomotic strictures and post-corrosive esophagitis are the most frequent types of cicatricial esophageal stricture. Congenital esophageal stenosis has been reported to be a rare but typical disease in children; other pediatric conditions are peptic, eosinophilic esophagitis and dystrophic recessive epidermolysis bullosa strictures. The conservative treatment of esophageal stenosis and strictures (ES) rather than surgery is a well-known strategy for children. Before planning esophageal dilation, the esophageal morphology should be assessed in detail for its length, aspect, number and level, and different conservative strategies should be chosen accordingly. Endoscopic dilators and techniques that involve different adjuvant treatment strategies have been reported and depend on the stricture's etiology, the availability of different tools and the operator's experience and preferences. Balloon and semirigid dilators are the most frequently used tools. No high-quality studies have reported on the differences in the efficacies and rates of complications associated with these two types of dilators. There is no consensus in the literature regarding the frequency of dilations or the diameter that should be achieved. The use of adjuvant treatments has been reported in cases of recalcitrant stenosis or strictures with evidence of dysphagic symptoms. Corticosteroids (either systemically or locally injected), the local application of mitomycin C, diathermy and laser ES sectioning have been reported. Some authors have suggested that stenting can reduce both the number of dilations and the treatment length. In many cases, this strategy is effective when either metallic or plastic stents are utilized. Treatment complications, such esophageal perforations, can be conservatively managed, considering surgery only in cases with severe pleural cavity involvement. In cases of stricture relapse, even if such relapses occur following the execution of well

  6. Vigilância epidemiológica do tracoma em instituição de ensino na cidade de São Paulo, SP

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    Medina Norma H.

    1998-01-01

    Full Text Available OBJETIVO: Verificar as condições de vigilância epidemiológica do tracoma desencadeadas a partir da detecção de um caso de tracoma inflamatório na APAE - SP. MATERIAL E MÉTODO: Foram submetidos a exame ocular 1.009 pessoas entre alunos, funcionários e comunicantes intradomiciliares. Os controles de tratamento foram realizados em uma instituição, por 4 vezes, em intervalos de 45 dias. RESULTADOS: A prevalência total foi de 5,9%, sendo 5,1% de tracoma folicular (TF, 0,3% de tracoma folicular intenso (TF/TI e 0,5% de tracoma cicatricial (TS. No primeiro controle 45,5% dos casos apresentou alta clínica e 40,0% manteve tratamento. No último controle 20,0% apresentou alta curado sem cicatrizes. A taxa de faltosos alcançou 38,2%. A distribuição espacial dos casos secundários mostrou ampla dispersão na Grande São Paulo, indicando que o tracoma deve estar disseminado por toda a região. DISCUSSÃO/CONCLUSÕES: As ações de controle do tracoma não apresentaram resultados satisfatórios, provavelmente devido ao prolongado tempo de tratamento e acompanhamento. Estratégias de intervenção clínica devem ser desenvolvidas para melhor controle da doença.

  7. Vigilância epidemiológica do tracoma em instituição de ensino na cidade de São Paulo, SP

    Directory of Open Access Journals (Sweden)

    Norma H. Medina

    1998-02-01

    Full Text Available OBJETIVO: Verificar as condições de vigilância epidemiológica do tracoma desencadeadas a partir da detecção de um caso de tracoma inflamatório na APAE - SP. MATERIAL E MÉTODO: Foram submetidos a exame ocular 1.009 pessoas entre alunos, funcionários e comunicantes intradomiciliares. Os controles de tratamento foram realizados em uma instituição, por 4 vezes, em intervalos de 45 dias. RESULTADOS: A prevalência total foi de 5,9%, sendo 5,1% de tracoma folicular (TF, 0,3% de tracoma folicular intenso (TF/TI e 0,5% de tracoma cicatricial (TS. No primeiro controle 45,5% dos casos apresentou alta clínica e 40,0% manteve tratamento. No último controle 20,0% apresentou alta curado sem cicatrizes. A taxa de faltosos alcançou 38,2%. A distribuição espacial dos casos secundários mostrou ampla dispersão na Grande São Paulo, indicando que o tracoma deve estar disseminado por toda a região. DISCUSSÃO/CONCLUSÕES: As ações de controle do tracoma não apresentaram resultados satisfatórios, provavelmente devido ao prolongado tempo de tratamento e acompanhamento. Estratégias de intervenção clínica devem ser desenvolvidas para melhor controle da doença.

  8. [Combined treatment of arteriovenous malformations of the head and neck].

    Science.gov (United States)

    Galich, S P; Dabizha, A Iu; Gindich, O A; Ogorodnik, Ia P; Al'tman, I V; Gomoliako, I V; Guch, A A

    2015-01-01

    An arteriovenous malformation (AVM) is a vascular developmental abnormality conditioned by impaired embryonic morphogenesis and characterized by the development of an abnormal connection between arteries and veins. More than 50% of the total number of patients suffering from this pathology are those having the pathological foci localizing in the area of the head and neck. At present, a combined method is both a generally accepted and the most radical one used for treatment for AVM. However, in the majority of cases, excision of the malformation leaves an extensive and complicated defect of tissues, whose direct closure leads to coarse cicatricious deformities. Over the period from 2004 to 2012, we followed up a total of 37 patients presenting with arteriovenous malformations of the head and neck. At admission the patients underwent preoperative examination including clinical tests, ultrasound duplex scanning, arteriography, MRT, and computed tomography. 24-72 hours prior to the operative intervention the patients were subjected to embolisation of the main vessels supplying the vascular malformation. Excision of the AVM was in 8 cases followed by primary closure of the postoperative wound, in 17 patients the defect was closed by transposition of the axial flaps, and 12 subjects underwent free transplantation of composite complexes of tissues. Relapse of the disease was revealed in 17 patients. In the majority of cases, relapses developed during the first year after the operative intervention (10 cases). The control of the disease's course was obtained in 20 patients. In 8 of the 12 patients with free transplantation of flaps we managed to obtain long-term control over the disease's course (more than 5 years). Hence, free microsurgical transplantation of compound complexes of tissues may be considered as a method of choice for closing the defect after excising an AVM in the area of the head and neck. Replacement of the defect with a well-vascularized tissue complex

  9. The role of PPARγ-mediated signalling in skin biology and pathology: new targets and opportunities for clinical dermatology.

    Science.gov (United States)

    Ramot, Yuval; Mastrofrancesco, Arianna; Camera, Emanuela; Desreumaux, Pierre; Paus, Ralf; Picardo, Mauro

    2015-04-01

    Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that modulate the expression of multiple different genes involved in the regulation of lipid, glucose and amino acid metabolism. PPARs and cognate ligands also regulate important cellular functions, including cell proliferation and differentiation, as well as inflammatory responses. This includes a role in mediating skin and pilosebaceous unit homoeostasis: PPARs appear to be essential for maintaining skin barrier permeability, inhibit keratinocyte cell growth, promote keratinocyte terminal differentiation and regulate skin inflammation. They also may have protective effects on human hair follicle (HFs) epithelial stem cells, while defects in PPARγ-mediated signalling may promote the death of these stem cells and thus facilitate the development of cicatricial alopecia (lichen planopilaris). Overall, however, selected PPARγ modulators appear to act as hair growth inhibitors that reduce the proliferation and promote apoptosis of hair matrix keratinocytes. The fact that commonly prescribed PPARγ-modulatory drugs of the thiazolidine-2,4-dione class can exhibit a battery of adverse cutaneous effects underscores the importance of distinguishing beneficial from clinically undesired cutaneous activities of PPARγ ligands and to better understand on the molecular level how PPARγ-regulated cutaneous lipid metabolism and PPARγ-mediated signalling impact on human skin physiology and pathology. Surely, the therapeutic potential that endogenous and exogenous PPARγ modulators may possess in selected skin diseases, ranging from chronic inflammatory hyperproliferative dermatoses like psoriasis and atopic dermatitis, via scarring alopecia and acne can only be harnessed if the complexities of PPARγ signalling in human skin and its appendages are systematically dissected. PMID:25644500

  10. Collagen IV in normal skin and in pathological processes

    Directory of Open Access Journals (Sweden)

    Ana Maria Abreu-Velez

    2012-01-01

    Full Text Available Context: Type IV collagen is a type of collagen found primarily in the skin within the basement membrane zone. The type IV collagen C4 domain at the C-terminus is not removed in post-translational processing, and the fibers are thus link head-to-head, rather than in a parallel fashion. Also, type IV collagen lacks a glycine in every third amino-acid residue necessary for the tight collagen helix. Thus, the overall collagen-IV conformation is structurally more pliable and kinked, relative to other collagen subtypes. These structural features allow collagen IV to form sheets, which is the primary structural form found in the cutaneous basal lamina. There are six human genes associated with collagen IV, specifically COL4A1, COL4A2, COL4A3, COL4A4, COL4A5 and COL4A6. The aim of this review is to highlight the significance of this protein in normal skin, and in selected diseases. Results: The alpha 3 protein constituent of type IV collagen is thought to be the antigen implicated in Goodpasture′s syndrome, wherein the immune system attacks the basement membranes of the renal glomeruli and pulmonary alveoli. In addition, mutations to the genes coding for type IV collagen lead to the Alport syndrome. Furthermore, autoantibodies directed against denatured human type IV collagen have been described in rheumatoid arthritis, scleroderma, and SLE. Structural studies of collagen IV have been utilized to differentiate between subepidermal blistering diseases, including bullous pemphigoid, acquired epidermolysis bullosa, anti-epiligrin cicatricial pemphigoid, and bullous lupus erythematosus. Collagen IV is also of importance in wound healing and in embryogenesis. Conclusions: Pathological studies have demonstrated that minor structural differences in collagen IV can lead to distinct, clinically different diseases.

  11. Lichen planopilaris: Demographic, clinical and histopathological characteristics and treatment outcomes of 25 cases

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    Deren Özcan

    2015-12-01

    Full Text Available Background and Design: Lichen planopilaris (LPP is a type of cicatricial alopecia characterized by autoreactive lymphocytic destruction of the hair follicle. We aimed to evaluate the demographic, clinical and histopathological features, and treatment outcomes of patients with LPP. Materials and Methods: Medical reports of 25 patients, who have been diagnosed with LPP according to the clinical and histopathological findings between January 2006 and June 2012, were retrospectively reviewed. The transverse and vertical sections of scalp biopsy specimens were re-evaluated by a pathologist, and the findings were noted. Results: Of the 25 patients, 18 were female and 7 were male, the mean age was 49.8±12.4 years. Eighteen patients had been diagnosed with classic LPP and 7 patients with frontal fibrosing alopecia (FFA. The alopecia has begun in postmenopausal period in 5 patients with FFA. Alopecia was associated with pruritus, pain and/or burning in 19 patients. Extra-scalp involvement was observed in 11 patients. The most common clinical findings were follicular hyperkeratosis (92%, perifollicular erythema (48%, perifollicular lichenoid papules, and positive hair-pull test (44%. Dermatoscopic examination was performed in 14 patients, and most commonly, absence of follicular openings (100%, perifollicular scales (92.9% and perifollicular erythema (50% were noted. The most common diagnostic histopathological findingsmwere follicular vacuolar and lichenoid degeneration (88% and vacuolar and lichenoid interface changes (56%. Twenty-three patients who were started on treatment received topical, intramuscular and intralesional corticosteroids, topical minoxidil, oral tetracycline, cyclosporine A, and hydroxychloroquine either alone or in combination. Progression of alopecia was prevented and the symptoms and/or signs were reduced in 12 (75% of 16 patients whose follow-up data were available. Conclusion: LPP can be diagnosed accurately through a detailed

  12. Prostaglandin E receptor subtype EP3 expression in human conjunctival epithelium and its changes in various ocular surface disorders.

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    Mayumi Ueta

    Full Text Available BACKGROUND: In our earlier genome-wide association study on Stevens-Johnson Syndrome (SJS and its severe variant, toxic epidermal necrolysis (TEN, we found that in Japanese patients with these severe ocular surface complications there was an association with prostaglandin E receptor 3 (EP3 gene (PTGER3 polymorphisms. We also reported that EP3 is dominantly expressed in the ocular surface-, especially the conjunctival epithelium, and suggested that EP3 in the conjunctival epithelium may down-regulate ocular surface inflammation. In the current study we investigated the expression of EP3 protein in the conjunctiva of patients with various ocular surface diseases such as SJS/TEN, chemical eye burns, Mooren's ulcers, and ocular cicatricial pemphigoid (OCP. METHODOLOGY/PRINCIPAL FINDINGS: Conjunctival tissues were obtained from patients undergoing surgical reconstruction of the ocular surface due to SJS/TEN, chemical eye burns, and OCP, and from patients with Mooren's ulcers treated by resection of the inflammatory conjunctiva. The controls were nearly normal human conjunctival tissues acquired at surgery for conjunctivochalasis. We performed immunohistological analysis of the EP3 protein and evaluated the immunohistological staining of EP3 protein in the conjunctival epithelium of patients with ocular surface diseases. EP3 was expressed in the conjunctival epithelium of patients with chemical eye burns and Mooren's ulcer and in normal human conjunctival epithelium. However, it was markedly down-regulated in the conjunctival epithelium of SJS/TEN and OCP patients. CONCLUSIONS: We posit an association between the down-regulation of EP3 in conjunctival epithelium and the pathogenesis and pathology of SJS/TEN and OCP, and suggest a common mechanism(s in the pathology of these diseases. The examination of EP3 protein expression in conjunctival epithelium may aid in the differential diagnosis of various ocular surface diseases.

  13. Effect of adipose tissue extract of greater omentum on human fibroblasts in vitro%大网膜脂肪组织提取液对成纤维细胞作用的研究

    Institute of Scientific and Technical Information of China (English)

    张小文; 吴涛; 邹浩; 王琨; 黄松泉

    2011-01-01

    Objective To study effect of the adipose tissue extract of greater omentum on human fibroblasts. Method The effect of the adipose tissue extract of greater omentum on human fibroblasts was observed by inverted microscope, MTT, flow cytometry, transmission electron microscope. Results The growth of fibroblasts was inhibited by the adipose tissue extract of greater omenturn. The apoptosis of fibroblasts was not inhibited, and the cell function of fibroblasts was inhibited and the mitosis of fibroblasts was affected. Conclusions The growth of fibroblasts can be inhibited by the adipose tissue extract of greater omentum. The formation and development of biliary cicatricial constriction may be affected by the adipose tissue extract of greater omentum.%目的 探讨大网膜脂肪组织提取液对成纤维细胞的作用.方法 应用倒置显微镜、MTT法、流式细胞仪、透射电镜观测提取液对成纤维细胞生长、增殖、凋亡以及细胞超微结构的影响.结果 大网膜脂肪组织提取液对成纤维细胞的生长增殖有抑制作用;抑制细胞凋亡,并影响细胞的有丝分裂,并使细胞功能受到抑制.结论 大网膜脂肪组织提取液可以抑制成纤维细胞的生长,有可能影响胆管瘢痕狭窄的形成和发展.

  14. Emergency peripartum hysterectomy, physical and mental consequences: a 6-year study

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    Denisa-Oana Bălălău

    2016-04-01

    Full Text Available Emergency peripartum hysterectomy (EPH is performed for massive postpartum hemorrhage following a cesarean delivery or vaginal delivery, in order to save the patient’s life. The current study was performed on a sample of 13.162 patients, which underwent cesarean or vaginal delivery during a period of 6 years, from 2010 to 2015, in Bucur Maternity Hospital. There were two subsequential groups consisting in: 6593 patients with cesarean operations and 6569 patients with vaginal delivery. In 12 cases occurred one or more of the risk factors that lead to EPH, divided equally across the two groups above. The main two types of surgery are a more frequent subtotal hysterectomy, which is the preferred type of EPH as it takes less time and is associated with fewer complications, and a total hysterectomy. The majority of procedures were performed at patients over 35 years old (9 of 12, with a median age of 31,16 (ranging from 21 to 44 years old. The most important risk factor present across the lot was multiparity (11 from 12, with cicatricial uterus being the second one (4 of 12. ICU median time was 4,5 days (ranging from 3 to 15 days, with a median blood transfusion necessity of around 2,4 I.U per patient. There were no mother or newborn reported deaths, neither PTSD following EPH.EPH is a procedure performed as last-resort, life-saving surgery, leaving no time for mental preparation of the patients. This may predispose to negative psychological outcomes, especially because they are not part of decision-making process due to the emergency character of hysterectomy.

  15. An advanced rectal carcinoma treated with radical radiotherapy using a proton beam

    Energy Technology Data Exchange (ETDEWEB)

    Miyo, Yasushi; Koyama, Shohei; Kobayashi, S. (Tsukuba Univ., Ibaraki (Japan). Inst. of Clinical Medicine) (and others)

    1991-07-01

    The authors present the case of a 72-year-old man admitted to hospital because of anal bleeding. A barium enema and subsequent endoscopic studies revealed a Borrmann type 3, well-differentiated adenocarcinoma of the rectum, with marked narrowing at the Rb to Ra region. On the basis of CT scans, a metastasis to the regional lymph nodes and the softer fatty tissue in the pelvic space was suspected. As surgery was contraindicated since an abnormal antibody against the erythrocytes was detected in the patient's blood, radical radiotherapy was pursued to cure the rectal cancer. Thus, a 250 MeV proton beam was administered to the primary lesion, and a total dose of 90 Gy was delivered in 28 fractions of 3 to 4 Gy daily over 64 days. In addition, X-ray therapy, using a 12 MV linear accelerator and a total dose of 50.4 Gy in 28 fractions of 1.8 Gy, was used for the treatment of a regional lymph node metastasis in the pelvic space. Three years and five months later, the patient died of an occlusive ileus of the rectum. On autopsy, the rectum revealed organized cicatricial fibrosis with marked stenosis. Further, the histological findings of the irradiated tumor cells showed massive fibrosis and hyalinized connective tissue. Vital cancer cells only were found in small parts of the primary rectal lesion, and the biological significance of these small clusters of vital tumor cells is discussed. Finally, neither a regional lymph node metastasis nor a distant metastasis, i.e., to the liver and/or lung, were observed. In conclusion, proton beam therapy was seen to have a beneficial effect on this rectal cancer and on the local control of the disease. (author).

  16. Experiencia con el colgajo de Kirschbaum en secuelas de quemaduras cérvico-faciales

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    P. Rossell-Perry

    2014-06-01

    Full Text Available Presentamos nuestra experiencia con el colgajo de Kirschbaum (colgajo en charretera en la corrección de retracciones cicatriciales de la región cervical anterior y del tercio inferior de la cara. Llevamos a cabo un estudio retrospectivo sobre una serie de 63 pacientes con retracciones cicatriciales de la región cervical anterior y del tercio inferior facial, operados por el primer autor entre los años 1996 y 2012 dentro del marco de las campañas quirúrgicas desarrolladas a lo largo del país (Perú en las áreas geográficas con mayor necesidad de atención especializada. En todos los casos empleamos el colgajo en charretera tomado de la región lateral del cuello y de la región deltoidea. Evaluamos a los pacientes mediante el examen físico y la documentación fotográfica obtenida en los periodos pre y postoperatorio. Obtuvimos mejoría en diferentes grados de la limitación funcional de la región cervical y facial en todos los casos operados, con viabilidad total del colgajo en 59 casos (93,65 % y parcial en 4 casos (6,34 % . No hubo ningún caso de pérdida total. Las complicaciones recogidas fueron pocas, principalmente hematomas, 6 casos (9,52 % e infección, 2 casos (3,17 % . Las zonas donantes evolucionaron con cicatriz hipertrófica en 22 de los casos (34,92 % . En conclusión, nuestra experiencia con el uso de esta técnica quirúrgica ha demostrado ser de utilidad en el tratamiento de las secuelas de quemadura con retracción cicatricial cervical y facial, por lo que consideramos que el colgajo de Kirschbaum es seguro y tiene pocas complicaciones.

  17. Sarcoidose cutânea sobre cicatrizes: relato de caso Sarcoidosis on skin scars: a case report

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    Sônia Antunes de Oliveira Mantese

    2010-12-01

    Full Text Available A sarcoidose é uma doença inflamatória sistêmica, de etiologia desconhecida, em que granulomas não caseosos são encontrados nos órgãos acometidos. O envolvimento cutâneo ocorre em 25% dos casos, com grande polimorfismo lesional. O acometimento de cicatrizes é incomum, porém clinicamente característico de sarcoidose cutânea. A maioria dos pacientes com sarcoidose cicatricial tem doença sistêmica. Relata-se o caso de uma paciente de 65 anos, que apresentou nodulações sobre cicatrizes 20 anos, após a realização de procedimentos cirúrgicos, sem manifestações sistêmicas. Salienta-se a importância de se investigar sarcoidose em cicatrizes prévias, com alterações inflamatórias.Sarcoidosis is a systemic inflammatory disorder of unknown origin, in which non-caseating granulomas (small inflammatory nodules are found in the affected organs. Cutaneous involvement occurs in 25% of cases with a wide range of clinical presentation. The onset of scars is unsual although clinically characteristic of cutaneous sarcoidosis. Most patients with scar sarcoidosis have a systemic disease. It is reported the case of a 65 year-old woman that developed scar nodules 20 years after she had had surgical procedures without systemic manifestations. It is worth mentioning the importance of investigating sarcoidosis with inflammatory alterations in praevia scars.

  18. Temporal-parietal occipital hair transplantattion on therapy large scarring alopecia%颞顶枕部毛发移植治疗枕部大面积瘢痕性秃发

    Institute of Scientific and Technical Information of China (English)

    王勇; 李兴东; 马文熙

    2015-01-01

    Objective To explore a treatment after occipital large cicatrial alopecia is more ideal method. Methods Using FUE technique to extract the occipital and planting to the scar at the top of the hair follicles. Results This group of 18 patients,scar tissue after an opera to achieve,postoperative implant hair growed well,scar was overwritten,extremely matural appearance,bothdoctors were satisfied. Conclusions The FUE technology treatment of occipital large cicatricial alopecia operation time,little pain,quick recovery,natural and beautiful appearance,in the caseof occipital resources can be extracted at the top of the hair follicles to grow,the method is worth promoting.%目的:探索一种治疗枕部大面积瘢痕性秃发的更为理想的方法.方法:采用单位毛囊提取术(Follicular Unit Extraction,FUE)提取枕部及颞顶部毛囊种植到瘢痕处.结果:本组18例患者,均经一次手术达到瘢痕修复目的,术后植入的毛发生长良好,瘢痕部位被覆盖,外观极其自然,医患双方均满意.结论:采用FUE技术提取颞、顶、枕部毛囊治疗枕部大面积瘢痕性秃发手术时间短、患者痛苦小、术后恢复快、外观自然美观,该方法值得推广.

  19. Membrana de PLDLA-TMC como protetor na regeneração do tendão calcâneo: Estudo in vivo em coelhos

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    Julia Rezende Duek

    2014-06-01

    Full Text Available Um dos maiores problemas da cirurgia restauradora dos tendões flexores é evitar a formação de aderências, pois limita seu deslizamento. Assim, é muito desejável que a cicatrização ocorra o mais rápido possível, restaurando a capacidade de deslizamento dos tendões, sem limitações dos movimentos. O objetivo deste trabalho foi analisar a resistência do Tendão calcâneo, utilizando membrana de PLDLA-TMC como protetor da aderência dos tecidos adjacentes após implantes em coelhos New Zeland. Foram utilizados 20 coelhos, divididos em dois grupos, os quais foram submetidos à secção do tendão calcâneo e posterior sutura com técnica de Kessler modificada. No grupo A, logo após sutura o animal foi sacrificado e o tendão foi enviado para ensaio mecânico. Já no grupo B, após três semanas, os animais foram sacrificados e o material foi submetido à análise histológica. Os resultados obtidos a partir do ensaio mecânico mostraram melhora nos valores da resistência à tração dos implantes com a membrana, comparados aos apenas suturados. Na cicatrização da lesão, ocorreu melhor organização das fibras colágenas quando foi utilizado o polímero PLDLA-TMC, além de uma menor aderência cicatricial. Conclui-se que a membrana de PLDLA-TMC é promissora na reparação de lesões tendíneas.

  20. Intralesional polysulphated glycosaminoglycan as treatment of equine collagenase induced tendinitis: clinical, ultrasonographic and histopathologic evaluation Polissulfato de glicosaminoglicanas no tratamento intralesional de tendinite induzida em eqüinos: avaliação clínica, ultra-sonográfica e histopatológica

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    S. Marxen

    2004-12-01

    Full Text Available The effect of intratendineous injections of polysulphated glycosaminoglycan (PSGAG as treatment of collagenase-induced tendonitis was studied. Two groups (GI and GII of five Arabian horses each, males and females, two to six year-old, were submitted to experimental tendinitis of the superficial digital flexor tendon of the left thoracic limb by intratendineous injection of 1.0ml of collagenase (2.5mg/ml. Seven days after the induced-lesions were created, the horses of GI received five intralesional injections of 1.0ml (125mg of PSGAG, every four days. Horses of GII received injections of saline in the same dose and rate. Clinical and ultrasonographic evaluations were performed periodically, during 150 days. All animals showed lameness, increased local pain, heat and swelling 24 hours after the injury was created. All signs, except to swelling, which remained visible by the end of the study, showed regression in all animals. Lesions of variable size, shape and position were evidenced by the ultrasonographic evaluation, reaching maximum severity between the seventh and the 23rd days. By the end of the study, the echogenicity grade ranged from 1 to 2, and the grade of fiber alignment from 0 to 2. The histopathologic analysis demonstrated repair areas with intense fibroplasia and neovascularization, collagen fibers poorly organized, and thickened hypercellular endotenon. The data of this study did not show significant differences between the treated and control groups, therefore leading to the conclusion that the intralesional injection of PSGAG did not have beneficial effects in the treatment of collagenase-induced tendinitis.Estudou-se o efeito de aplicações intratendíneas do polissulfato de glicosaminoglicanas (PSGAG no tratamento de tendinite induzida pela colagenase. Dois grupos (GI e GII de cinco eqüinos da raça Puro-Sangue Árabe, machos e fêmeas, com idades entre dois e seis anos, foram submetidos à tendinite do tendão flexor digital

  1. Effects of bandage compression and the specific radial hemostasis in patients undergoing transradial coronary intervention%经桡动脉冠状动脉介入术后常规止血与器械止血临床效果的对比研究

    Institute of Scientific and Technical Information of China (English)

    杨清; 周玉杰; 聂斌; 刘晓丽; 成万钧; 王建龙

    2010-01-01

    目的 探讨经桡动脉冠状动脉介入检查与治疗(TRI)术后常规弹力绷带加压止血、专用桡动脉板式止血器和气囊加压式止血器3种方法在止血效果、预防穿刺血管并发症等方面的差异.方法 将连续入选行TRI的3000例患者随机分入常规弹力绷带加压止血组(ER组)、板式止血器组(TB组)和气囊加压式止血器组(TR组),最终合格入选研究的患者ER组963例,TB组976例,TR组971例.入选标准:Allen试验阳性;初次行TRI;成功置入6 F桡动脉鞘管.主要研究终点为住院期间术后桡动脉血管并发症,次要研究终点包括血管并发症危险因素、桡动脉止血时间、纤维组织增生情况、患者舒适度.结果 ER组、TB组、TR组术后血管并发症发生率差异无统计学意义(分别为12.7%、10.6%、10.7%,P=0.262).3组桡动脉闭塞发生率总体存在差异(P=0.049),但两两比较差异无统计学意义.多因素回归分析提示,女性、低体重、手术时间、穿刺次数是血管并发症危险因素.与ER组比较,TB组、TR组止血时间较短[(274±57)min、(265±61)min比(332±54)min,均P<0.001],术后穿刺部位纤维硬结发生率较低(8.8%、7.9%比13.6%,均P<0.001).术后患者舒适度TB组、TR组明显优于ER组(均P<0.001).结论 常规弹力绷带和桡动脉专用止血器械均安全有效,但后者止血时间更短、患者舒适度更高.%Objective To compare the effects of elastic bandage compression with the specific hemostasis devices in patients undergoing transradial coronary intervention. Methods A total of 3000 consecutive patients were randomized to 3 groups and 2910 patients completed the study, 963 patients in elastic bandage group(ER), 976 in T band group(TB)and 971 in balloon group(TR). In-hospital vascular related complication was the primary study endpoint. The secondary endpoints included: risk factors of complications, compression time, fibroplasias conditions and the comfort feeling of

  2. Carcinomas basocelulares: estudo clínico e anatomopatológico de 704 tumores Basal cell carcinomas: anatomopathological and clinical study of 704 tumors

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    Aurilene Monteiro Bandeira

    2003-02-01

    Full Text Available FUNDAMENTOS: Este é um estudo retrospectivo e anatomopatológico de 704 carcinomas basocelulares de 623 pacientes, diagnosticados no período de 1991 a 1996, no setor de Dermatopatologia da Clínica Dermatológica do Hospital das Clínicas da UFPE e em um laboratório privado de dermatopatologia da cidade do Recife. OBJETIVOS: Caracterizar aspectos clínicos e anatomopatológicos dos carcinomas basocelulares diagnosticados nos dois serviços da região de Pernambuco. MÉTODOS: Para o estudo clínico, os dados foram retirados dos prontuários e para o estudo anatomopatológico, macro e microscópicos, foram feitas revisão dos preparados histológicos. Para o crescimento vertical empregaram-se métodos baseados nas técnicas histoprognósticas de Clark e Breslow, aplicadas ao melanoma maligno. RESULTADOS: Clínicos: a maior incidência foi no sexo feminino (55,7%, faixa etária de 55 a 72 anos, tempo de evolução com variabilidade elevadíssima, desde um mês a 40 anos, e a cabeça foi a região topográfica mais freqüente (73,8%, principalmente nasal (21,1% e zigomática (18,5%. A forma nodular pigmentada (47,4% foi a mais encontrada e o tamanho das lesões independeu do tempo evolutivo. Histologicamente os padrões considerados baseados apenas nos arranjos parenquimais, foram os adenóide, compacto, fibroepitelial de Pinkus plexiforme, pseudocístico, reticulado, superficial e tricoepitelial, predominando o adenóide (28,3%. A média de crescimento foi em 2/3 da derme reticular (32,4%, e os tumores que mais se aprofundaram mostraram fibroplasia intensa. Houve concomitância de vários tipos celulares em um mesmo tumor e o pigmento melânico esteve mais presente nos tricoepitelioides. CONCLUSÃO: A fundamental importância da caracterização clínica e anatomopatológica dos carcinomas basocelulares destes serviços, sem diferenças muito significativas para os grupos e atenção para definições comportamentais e proposições ao relat

  3. Fatores envolvidos na migração das endopróteses em pacientes submetidos ao tratamento endovascular do aneurisma da aorta abdominal Factors involved in the migration of endoprosthesis in patients undergoing endovascular aneurysm repair

    Directory of Open Access Journals (Sweden)

    Marcelo José de Almeida

    2010-06-01

    Full Text Available A migração da endoprótese é complicação do tratamento endovascular definida como deslocamento da ancoragem inicial. Para avaliação da migração, verifica-se a posição da endoprótese em relação a determinada região anatômica. Considerando o aneurisma da aorta abdominal infrarrenal, a área proximal de referência consiste na origem da artéria renal mais baixa e, na região distal, situa-se nas artérias ilíacas internas. Os pacientes deverão ser monitorizados por longos períodos, a fim de serem identificadas migrações, visto que estas ocorrem normalmente após 2 anos de implante. Para evitar migrações, forças mecânicas que propiciam fixação, determinadas por características dos dispositivos e incorporação da endoprótese, devem predominar sobre forças gravitacionais e hemodinâmicas que tendem a arrastar a prótese no sentido caudal. Angulação, extensão e diâmetro do colo, além da medida transversa do saco aneurismático, são importantes aspectos morfológicos do aneurisma relacionados à migração. Com relação à técnica, não se recomenda implante de endopróteses com sobredimensionamento excessivo (> 30%, por provocar dilatação do colo do aneurisma, além de dobras e vazamentos proximais que também contribuem para a migração. Por outro lado, endopróteses com mecanismos adicionais de fixação (ganchos, farpas e fixação suprarrenal parecem apresentar menos migrações. O processo de incorporação das endopróteses ocorre parcialmente e parece não ser suficiente para impedir migrações tardias. Nesse sentido, estudos experimentais com endopróteses de maior porosidade e uso de substâncias que permitam maior fibroplasia e aderência da prótese à artéria vêm sendo realizados e parecem ser promissores. Esses aspectos serão discutidos nesta revisão.Migration of the endoprosthesis is defined as the misplacement of its initial fixation. To assess the migration, the position of the

  4. Preventive effects of chitosan on peritoneal adhesion in rats

    Institute of Scientific and Technical Information of China (English)

    Zhi-Liang Zhang; Si-Wei Xu; Xie-Lai Zhou

    2006-01-01

    AIM: To study the effects of chitosan gel and blending chiston/gelatin film on preventing peritoneal adhesion in rats.METHODS: SD rats were randomly divided into 2groups, group A treated with chitosan gel and group B with blending chiston/gelatin film. In group A, rats were randomly subdivided into 3 subgroups as groups A1,A2 and A3, and different methods were used to induce peritoneal adhesions at the dead end of vermiform process in each group as follows: Group A1 with trauma,A2 with talc powder and A3 with ligation of blood vessel.In each subgroup, rats were redivided into control group and experimental group whose treated vermiform processes were respectively coated with chitosan gel and normal saline immediately after the adhesioninduced treatments. In group B, all the rats received traumatic adhesion-induced treatments and then were randomly divided into 4 groups (groups B1, B2, B3, B4).Group B1 served as control group and were coated with normal saline in the vermiform processes immediately after the treatments, and groups B2, B3 and B4 with 100% chitosan film, chitosan film containing 10% gelatin and chiston film containing 50% gelatin, respectively.At 2 and 4 wk after the above treatments, half of the rats in each terminal group were belly opened, and the peritoneal adhesive situation was graded and histopathological changes were examined.RESULTS: (1) In group A, regarding peritoneal adhesion situation: At both 2 and 4 wk after the treatments, for groups A1 and A3, the adhesive grades of experimental groups were significantly lower than those of the control group (2 wk:H=4.305, P<0.05 for A1, H = 6.743, P< 0.01 for A3; 4 wk:H= 4.459, P < 0.05 for A1,H=4.493, P < 0.05 for A3). However, of group A2, there was no significant difference between the experimental and control groups (2 wk:H= 0.147, P > 0.05; 4 wk:H=1.240, P>0.05). Regarding pathological changes:In groups A1 and A3, the main pathological change was fibroplasia. In group A2, the main

  5. Healing activity of laser InGaAlP (660nm in rats Atividade cicatrizante do laser AlGaInP (660nm em ratos

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    Kelly Cristina Borges Tacon

    2011-10-01

    Full Text Available PURPOSE: To evaluate the effect the healing activity of diode laser Indium Gallium Aluminum Phosphorus (InGaAlP ë660nm on healing of surgical wounds in rats. METHODS: Fifty-four female Wistar rats were used, divided into three groups (n=18 and subdivided into three subgroups (n=6 to be studied in 5, 10 and 15th days after surgical procedures. The wound was induced in the dorsal-cervical using punch. The lesions were irradiated on alternate days with InGaAlP laser, the energy densities of 3J/cm² (L3 or 6J/cm² (L6. The control group received no irradiation. At 5, 10 and 15th days after surgery the animals were euthanized and the repair area was removed and histological sections were stained with hematoxylin-eosin and picrossírius. We evaluated macroscopic and histological lesions in the times cited, as well as morphometric analysis of angiogenesis and collagen content. RESULTS: The wound healing activity InGaAlP laser was evidenced by increased angiogenesis group L3 and L6 in relation to control group (CG at the 5th day (p=0.0001 and decreased polymorphonuclear infiltrate and hemorrhage (p=0.045 and p=0.07 respectively in the groups L3 and L6 in relation to control group (GC. On the 10 and 15th days was also observed in groups treated with laser L3 and L6 stimulation was pronounced fibroplasia (p=0.0003 and p=0.034 respectively when compared with the control group (CG. CONCLUSION: The InGaAlP laser acted positively on the healing of skin wounds in rats.OBJETIVO: Avaliar a atividade cicatrizante do laser diodo Alumínio Gálio Índio Fósforo (AlGaInP, ë660nm em feridas cutâneas induzida em ratos. MÉTODOS: Foram utilizados 54 ratos Wistar, fêmeas, divididos em três grupos (n=18 e subdivididos em três subgrupos (n=6 animais para serem estudados no 5, 10 e 15º dias após o procedimento cirúrgico. A ferida foi induzida em região dorso-cervical utilizando punch. As lesões foram irradiadas em dias alternados com laser AlGaInP, nas

  6. Dacryocystorhinostomy ostium: parameters to evaluate and DCR ostium scoring

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    Ali MJ

    2014-12-01

    Full Text Available Mohammad Javed Ali,1 Alkis James Psaltis,2 Peter John Wormald2 1Dacryology Service, L V Prasad Eye Institute, Hyderabad, Telangana, India; 2Department of Surgery–Otorhinolaryngology, Head and Neck Surgery, The University of Adelaide, Adelaide, SA, Australia Aim: This study aims to provide a systematic protocol for the evaluation of a dacryocystorhinostomy (DCR ostium and to propose a scoring system to standardize the assessment.Methods: Retrospective evaluation of 125 consecutive lacrimal ostia post-DCR was performed. Medical records were screened, and photographs and videos were assessed to note the details of various ostial parameters. The major time points in evaluation were 4 weeks, 6 weeks, 3 months, and 6 months post-DCR. The ostia were defined and parameters like shape, size, location, and evolution of ostium were noted. Evaluation parameters were defined for internal common opening (ICO, ostium stents, and ostium granulomas. Ostium cicatrix and synechiae were graded based on their significance. Surgical success rates were computed and ostium characteristics in failed cases were studied.Results: A total of 125 ostia were evaluated on the aforementioned ostium parameters. Because five ostia showed a complete cicatricial closure with no recognizable features, the remaining 120 ostia were studied. The ostium location was anterior to the axilla of middle turbinate in 85.8% (103/120 of the cases. Moreover, 76.6% (92/120 of the ostia were circular to oval in shape, with a shallow base. The ostium size was >8×5 mm in 78.3% (94/120 of the cases. The ICO was found to be located in the central or paracentral basal area in 75.8% (91/120. The anatomical and functional success rates achieved were 96% and 93.6%, respectively. All the five cases with anatomical failures showed a complete cicatrization and the ICO movements were poor in all the three cases of functional failure.Conclusion: The article attempts to standardize the postoperative

  7. Injeção subconjuntival de soro autógeno no tratamento de queimadura ocular por álcali em coelhos Subconjunctival injection of autogenous blood in the treatment of ocular alcali burn in rabbits

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    Marcela Colussi Cypel

    2004-10-01

    Full Text Available OBJETIVO: Estudar a ação da injeção subconjuntival de soro autógeno na evolução das complicações, após queimadura ocular grave por álcali induzida experimentalmente em coelhos. MÉTODOS: Foram utilizados trinta olhos de coelhos da raça Nova Zelândia, divididos em dois grupos, de 15 coelhos cada, ambos submetidos à queimadura grave por álcali. Em 15 olhos (grupo tratado, efetuamos, imediatamente após a queimadura, injeção de soro autógeno subconjuntival. Os resultados foram avaliados e comparados logo após a queimadura e nos dias 1, 3, 7, 15 e 30 por meio de ectoscopia biomicroscopia ocular. RESULTADOS: O grupo tratado apresentou melhor resposta de reepitelização da córnea, na fase inicial do processo do que o grupo controle (grupo sem soro autógeno, diferença esta estaticamente significante, assim como resultado final com um menor número de complicações. CONCLUSÃO: Os resultados obtidos neste estudo experimental sugerem que soro autógeno pode ter efeito no processo de cicatrização dos olhos após queimadura alcalina, diminuindo complicações tardias e melhorando o prognóstico quanto à estabilidade do processo inflamatório cicatricial.PURPOSE: To determine the activity of subconjunctival injection of autogenous serum in the treatment of ocular alkali burn induced experimentally in rabbits. METHODS: Thirty eyes of 30 New Zeland albino rabbits were divided into two groups of 15 and submitted to ocular alkali burn. One group (treated group received immediately after the alkali burn a subconjunctival injection of autogenous serum. The results were compared and recorded immediately after the alkali burn and on days 1, 3, 7, 15, and 30 by external ocular examination and manual portable slit lamp. RESULTS: The treated group presented a better reepithelialization of the cornea than the control group, in the beginning of the process, with a statistically significant difference; and a final result with less complications

  8. Dilatação esofágica endoscópica associada ao uso de triancinolona intramural em cadela com estenose de esôfago após ovariohisterectomia eletiva

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    Marília Teresa de Oliveira

    2013-09-01

    Full Text Available A estenose esofágica adquirida ocorre normalmente em função de uma esofagite severa, resultando em processo cicatricial com proliferação de tecido fibroso. Entre as causas, encontra-se o refluxo gastroesofágico em animais anestesiados. O presente trabalho objetiva relatar o tratamento de estenose esofágica em uma cadela por dilatações luminais endoscópicas, associadas ao uso de triancinolona intralesional. Um canino, SRD, foi atendido com a queixa de regurgitação e emagrecimento progressivo. Esses sinais surgiram após a realização de OVH videolaparoscópica eletiva, durante a qual a paciente apresentou regurgitação no transoperatório. Com base no exame clínico e nos achados endoscópicos, foi possível confirmar o diagnóstico de estenose no terço final do esôfago cervical. Após o diagnóstico definitivo, iniciou-se o tratamento com dilatações esofágicas intraluminais endoscópicas e administração intralesional de triancinolona. Esse procedimento foi repetido uma vez por semana, durante quatro semanas. A quinta dilatação ocorreu após 14 dias da quarta dilatação. O paciente teve alta hospitalar após sete dias da quinta e última seção de dilatação esofágica e aplicação de triancinolona, não apresentando mais episódios de regurgitação, mesmo ao se alimentar com ração seca sem plano inclinado. Conclui-se que as dilatações esofágicas associadas ao uso de triancinolona intralesional foram efetivas no tratamento de estenose de esôfago no presente caso.

  9. Técnicas de sutura do tubo digestivo em plano único com nós atados no lume, em cães: pontos simples totais versus pontos extramucosos

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    Azevedo João Luiz Moreira Coutinho

    2005-01-01

    Full Text Available OBJETIVO: Comparar a anastomose do tubo digestivo em plano único com nós atados no lume por sutura com pontos totais versus pontos extramucosos. MÉTODOS: Foram operados seis cães, com realização de duas secções transversas do jejuno a 30 cm e a 70 cm da flexura duodenojejunal e sutura, na face posterior com pontos extramucosos atados sobre a submucosa, e na face anterior com pontos totais atados sobre a mucosa. No 7º PO foram avaliadas, na face posterior, as aderências na linha de sutura e feitos exames macroscópico e microscópico. RESULTADOS: As aderências peritoneais foram mais profusas nas suturas extramucosas com tecido aderencial sobre a linha de sutura, sem reconstituição da serosa, ou com a deformidade cicatricial das serosas dos cotos angulando a anastomose. A serosa teve boa reconstituição nas suturas totais. O epitélio mucoso reconstituiu-se perfeitamente nas extramucosas, mas não nas totais. Nas suturas totais houve focos residuais de inflamação aguda.O realinhamento, a reestruturação e a regeneração das camadas (exceto a serosa, cuja regeneração foi prejudicada por aderências foi melhor na sutura extramucosa que na total. A muscular da mucosa não se regenerou em nenhuma anastomose. Os polimorfonucleares, os macrófagos, os fibroblastos e as fibras colágenas foram mais numerosos (significância estatística na sutura total. CONCLUSÃO: As suturas totais da parede posterior da anastomose com nós atados no lume, sobre a mucosa, são seguras, apesar da inflamação maior. A sutura extramucosa da parede posterior, com nós atados no lume, sobre a submucosa, propicia a formação de aderências peritoneais, devendo ser evitada.

  10. ACCENTE ALE COMUNICARII PUBLICE ÎN CONTEXTUL CRIZEI ECONOMICE

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    Ştefania Bejan

    2013-07-01

    Full Text Available Devenit loc comun în istoria contemporană a lumii, fenomenul crizei economice apare fără preaviz și lasă cicatrici adânci în memoria individuală și colectivă, în proiectele sociale (politice, militare à la long în relațiile interumane…Oricât nu s-ar recunoaște, nimeni nu e vaccinat definitiv împotriva „bacilului crizei”; fiecare om rămâne marcat (o vreme, pentru totdeauna, sensibil, fundamental: unii savurează cu disperarea ultimei zile de existență momente, întâmplări, prietenii, dispute, călătorii, iubiri ,bani, orgolii; alții se luptă cu înverșunare să supraviețuiască, să-și dovedească puterea de a fi răzbit în pofida tuturor opreliștilor; unii se consolează, lipsiți de energia tinereții, a unui nou început, a unui miracol gen „Ce-ar fi, dacă ?”. Profesioniștii comunicării, alături de inși poposiți din eroare în domeniu (ne referim cu precădere la politicienii fără cea mai firavă vocație în acest sens își adaptează (strategic ? intuitiv? discursul destinat spațiului public și oferă o „stagiune” pestriță, tocmai bună de studiat la „Constituție”, „Cultură civică”, „PR în O.N.G.” etc. Accentele descoperite de cercetător țin proaspătă agenda mass-media și dau de lucru cetățenilor cu ceva brumă de preocupare vizând normalitatea societății în care s-au „nimerit”…

  11. Estudo comparativo do uso tópico de própolis verde e vermelha na reparação de feridas em ratos

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    Lara Lívia Valença Batista

    2012-12-01

    Full Text Available OBJETIVO: Avaliar a ação cicatrizante de própolis verde e vermelha, correlacionando ao teor de flavonoides MÉTODOS: Foi realizada a quantificação de flavonoides totais dos extratos etanólicos de própolis verde e vermelha para posterior incorporação em pomada base a 20%. Utilizou-se 20 ratos Wistar distribuídos em quatro grupos: solução salina a 0,9% (S, pomada base (B, pomada própolis verde (G, pomada própolis vermelha (R, todos submetidos à confecção de lesões excisivas na região mediana do dorso. Os ratos foram tratados diariamente durante 15 dias. Neste período foram observados peso; temperatura corporal; diâmetro das feridas. Para análise histológica, amostras das feridas foram coletadas. Ao fim do experimento foram realizadas coleta sanguínea e remoção do rim e fígado para análises bioquímica e histológica. RESULTADOS: Os teores de flavonoides totais das própolis verde (4,50 % e vermelha (5,92 % foram elevados (>2 %, mas, embora a segunda apresente teor maior que a primeira, a evolução da própolis verde, macro e histologicamente, foi melhor na reparação das feridas. Não foram observadas nefro ou hepatotoxicidade, resultado corroborado pelos ensaios bioquímicos (TGP e albumina. A própolis influiu na redução de colesterol total, triglicerídeos e glicemia. CONCLUSÃO: Não foi possível correlacionar o teor de flavonoides totais com a ação cicatrizante da própolis. O dado revela a necessidade da elucidação dos flavonoides encontrados em cada classe de própolis para desvendar qual (ou quais flavonoide(s seria(m representativo(s no processo cicatricial.

  12. Minilaparoscopic cholecystectomy a one year record.

    Science.gov (United States)

    Di Bartolomeo, Nicola; Mascioli, Federico; Ciampaglia, Franco

    2015-01-01

    trattati con tecnica minilaparoscopica. Anche il risultato estetico è stato migliore per l’inferiore lunghezza delle cicatrici residue. Le complicanze post-operatorie, seppur di scarsa entità, non sono risultate correlate alla metodica. La tecnica minilaparoscopica può quindi considerarsi sicura ed in grado di garantire risultati clinici sovrapponibili alla laparoscopia tradizionale purchè eseguita da laparoscopisti esperti. Inoltre riteniamo che questa metodica, con le sue difficoltà tecniche, possa avere la funzione di training per la preparazione dei chirurghi ad interventi di laparoscopia avanzata.

  13. Efeito cicatrizante e atividade antibacteriana da Calendula officinalis L. cultivada no Brasil Healing effect and antibacterial activity of Calendula officinalis L. cultivated in Brazil

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    L.M.L. Parente

    2009-01-01

    Full Text Available Desde a antiguidade propriedades medicinais são atribuídas às flores da Calendula officinalis L. (Asteraceae destacando-se a atividade cicatrizante. Estudos sobre a atividade geral de plantas medicinais na cicatrização vêm sendo realizados, sem especificar sobre qual das fases da cicatrização a planta atua. Neste trabalho a atividade cicatrizante e antiinflamatória do extrato etanólico das flores da C. officinalis cultivada no Brasil foi avaliada em feridas cutâneas de ratos Wistar, por meio de avaliação macroscópica e histológica. A atividade antimicrobiana do extrato e das frações hexânica e diclorometano também foi avaliada. A atividade antiinflamatória do extrato etanólico da calêndula foi atribuída à diminuição da exsudação serosa, da hiperemia, da deposição de fibrina e da hiperplasia epidermal, além de resultar em crostas mais delgadas e umedecidas. Observaram-se também aumento de colágeno no tecido de granulação e efeito antibacteriano. Assim, o extrato etanólico da calêndula atuou de forma positiva sobre a atividade cicatricial em feridas cutâneas de ratos, bem como apresentou atividade antibacteriana in vitro.Since ancient history medicinal properties are attributed to flowers of Calendula officinalis L. (Asteraceae, mainly concerning its healing activity. Studies about the general activity of medicinal plants in healing wounds have been conducted without specifying in which healing phase the plant acts. In this work, the anti-inflammatory and healing activity of the ethanolic extract of C. officinalis flowers cultured in Brazil was evaluated in cutaneous wounds of Wistar rats through macroscopic and histological evaluation. The antibacterial activity of the extract and dichloromethane and hexane fractions was also evaluated. The anti-inflammatory activity of calendula ethanolic extract led to a reduction in plasmatic exudation, hyperemia, fibrin deposition and epidermal hyperplasia, besides

  14. Ação da l-arginina na evolução de retalhos cutâneos de ratos sob exposição à nicotina

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    Marcus Vinicius Thomé Nora Guimarães

    2013-02-01

    Full Text Available OBJETIVO: Avaliar se o tratamento com L-arginina influencia a cicatrização de retalhos cutâneos em ratos expostos à nicotina. MÉTODOS: Foram utilizados 40 ratos Wistar pesando 142,4±10,1g separados em quatro grupos: GC- tratamento com solução tampão fosfatos pH 7,4, confecção de retalho cutâneo, observação por 10 dias; GN- exposição à nicotina por quatro semanas, confecção de retalho cutâneo, observação por dez dias; GA- tratamento com solução tampão fosfatos pH 7,4 por quatro semanas, confecção de retalho cutâneo, tratamento com arginina por dez dias; GAN- exposição à nicotina por quatro semanas, confecção de retalho cutâneo, tratamento com arginina por dez dias. Foram avaliadas as áreas de necrose, re-epitelização, reação inflamatória e formação de tecido de granulação, pela coloração HE, a área de deposição total e a diferenciação de colágenos I e III por histometria com a coloração de picrosirius, e, através da marcação imunoistoquímica com anticorpo monoclonal anti-CD34, a densidade vascular cicatricial. RESULTADOS: As porcentagens de áreas de necrose de GN e GNA foram maiores (p0,05 e maiores (p<0,001 do que em GA e em GNA e, nas densidades vasculares, GN e GAN foram menores (p<0,001 do que em GC e em GA. CONCLUSÃO: A exposição à nicotina inibiu os efeitos da arginina, e nos ratos não expostos, induziu melhora na angiogênese e na deposição de colágeno total nos retalhos cutâneos.

  15. Resection And Reconstructive-plastic Surgery In Treatment Of Extended And Multifocal Cicatrical Tracheal Stenosis

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    Otabek Eshonkhodjaev

    2015-12-01

    Full Text Available Background. Main issues of treatment of patients with cicatricial stenosis of trachea (CST are to increase its efficacy and safety, as well as to determine indications and contraindications for circular resection and reconstructive interventions on the trachea in patients with extended lesions of trachea, with stenoses involving subvocal cords part of larynx and well as multifocal narrowing of the trachea which could improve treatment results and quality of life of patients, to gain recovery and reduce disability and mortality.Material and methods. One hundred two patients aged from 11 to 62 years with CST were surgically treated. Stenotic site length in patients varied from 0,3 to 7 cm. Most frequently (64,2%, CST length of more than 2 cm was observed. In critical and decompensated stenosis with diameter of CST up to 5 mm with the threat of asphyxiation by the first stage we used endoscopic laser-and electric destruction of constriction followed by restricted zone bouging. If long-term rehabilitation was necessary and in case of absence of the conditions to the implementation of circular tracheal resection, we used tracheal stents. Circular resection of the trachea was performed in 24 patients. In case of contraindications, 28 patients underwent reconstructive plastic surgery with dissection the stenosis, excision of scar tissue and formation of trachea lumen in T-tube. After removing T-tube plasty of anterior tracheal wall and of soft tissues of the neck defects was performed using local tissues and grafts with microsurgical techniques.Results. Long-term results of treatment evaluated and studied in a period of 6 months to 5 years in 89 (87.3% patients. 13 patients continues to one of the stages of complex treatment. Еhe patients are under dynamic endoscopic control. Good results were achieved in the treatment of 71 patients (79.8%, satisfactory - in 12 (13.4%, unsatisfactory results in 6 (6.7% patients.Conclusions. 1. Patients with CST

  16. 小切口保留黄韧带手术治疗腰椎间盘突出症的研究%Analysis on treatment of lumbar disc herniation by minimal incision surgery with preserving the ligamentum flavum

    Institute of Scientific and Technical Information of China (English)

    杨永林; 胡泽元; 金霖峰; 高强

    2011-01-01

    Objective To evaluate the indications and effects of treatment of lumbar disc herniation by minimally incision fenestration laminectomy and lumbar discectomy surgery with preserving the ligamentum flavum.Methods Minimally incision fenestration laminectomy and lumbar discectomy surgery with preserving the ligamentum flavum were performed in 183 cases of lumbar disc herniation.The shallow ligamentum flavum was peeled and the deep ligamentum flavum was preserved.After lumbar discectomy, bring the ligamentum flavum back to its original location.Results 183 cases were followed up for 6 months to 3 years; the excellent rate was 90.2%.The patients were examined with CT and MRI after operation, the result showed that the ligamentum flavum was no deformation and dent, the scar tissue of spinal canal were stopped on ligamentum flavum.Conclusion Treatment of lumbar disc herniation by minimal incision fenestration lamineetomy and lumbar discectomy surgery with preserving the ligamentum flavum can effectively prevent cicatricial adhesion in canales spinalis.%目的 探讨小切口椎板间开窗保留黄韧带的椎间盘髓核摘除术治疗腰椎间盘突出症的疗效及适应证.方法 对183例腰椎间盘突出症患者行小切口椎板间开窗保留黄韧带的腰椎间盘髓核摘除术,剥离浅层黄韧带,保留深层黄韧带.摘除椎间盘髓核后将深层黄韧带恢复到原来的位置.结果 183例随访6个月~3年,优良率达90.2%,术后复查CT或MRI,可见相应黄韧带无变形或塌陷,椎管外瘢痕组织于黄韧带处中止.结论 小切口椎板间开窗保留黄韧带的腰椎间盘髓核摘除术能有效地防止术后椎管内瘢痕粘连.

  17. Influência da textura superficial dos implantes = Texture of the titanium implant surfaces

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    Nagem Filho, Halim

    2007-01-01

    Full Text Available Dentre as várias características dos implantes a topografia da superfície é reconhecida como fator capaz de alterar a resposta das células dos tecidos adjacentes modificando a migração, inserção, proliferação e síntese de colágeno no local, determinando assim o tipo de tecido que será obtido na interface osso-implante e sua integração. Graças aos diferentes tipos de tratamentos tornou-se possível obter várias formas de caracterização da superfície facilitando a compreensão dos padrões de formação óssea, comportamento das células e até mesmo prever o tipo cicatricial que será obtido a partir da conformação dos tecidos adjacentes às superfícies dos implantes. Superfície de titânio com a rugosidade e microestrutura complexa aumenta a osseointegração no contato osso e implante, eleva a força de torque de remoção in vivo e a diferenciação in vitro dos osteoblastos induzidos pela função de rugosidade e topografia na osseointegração. Em superfícies de implantes tratadas com plasma de titânio (TPS, jateadas com areia e tratadas com ácido (SLA os resultados demonstraram que tanto a rugosidade como o tratamento químico das superfícies pode influenciar bastante a força superficial de cisalhamento (resistência oferecida à remoção. Estas características da superfície do titânio, além de otimizar o procedimento, podem ainda, por exemplo, permitir a colocação dos implantes em função mais precocemente e ampliar a gama de aplicações possíveis para osso alveolar de densidade inferior ou favorecer sua aplicação em osso regenerado

  18. Comparação entre hidroxiapatita porosa de coral e enxerto ósseo autógeno em coelhos

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    Figueiredo Arthur Silveira de

    2001-01-01

    Full Text Available A transplantação de osso autógeno continua sendo usada com sucesso, apesar das limitações que apresenta, principalmente no que se refere à morbidade aumentada, operações adicionais e aumento do custo. O objetivo desta pesquisa foi verificar a integração da hidroxiapatita porosa de coral como alternativa biológica, em forma de cerâmica, para substituir o enxerto ósseo autógeno. Foram utilizados 42 coelhos albinos (Nova Zelândia, submetidos a defeito padrão em 84 côndilos femorais, e implantação aleatória, em cada lado, de enxerto ósseo autógeno ou hidroxiapatita porosa. Foram avaliados os aspectos da evolução clínica diária dos animais. Após duas, quatro e doze semanas, grupos de 14 animais foram sacrificados e feita a avaliação radiológica e macroscópica da integração dos enxertos. Peças das regiões operadas foram colhidas para estudo histológico dessa integração. Os resultados macroscópicos mostraram que a integridade óssea, coloração, cicatrização da cortical e mobilidade dos implantes não foram estatisticamente significantes para os dois tipos de enxertos, nos diferentes tempos de observação. A diferença de uma progressiva e melhor integração dos enxertos ocorreu apenas quando se compararam os três tempos de observação, e foi considerada como conseqüência direta da evolução natural do processo cicatricial. Os parâmetros radiológicos de integração seguiram o mesmo padrão dos achados macroscópicos. Os achados microscópicos mostraram que o aparecimento de tecido ósseo maduro é retardado nos enxertos de hidroxiapatita com a ocorrência de cavidades císticas. Concluiu-se que a hidroxiapatita porosa de coral foi um substituto adequado ao enxerto ósseo autógeno em coelhos.

  19. Prevalence of anti-gliadin antibody in patients with alopecia areata: a case-control study

    Directory of Open Access Journals (Sweden)

    Hallaji Z

    2011-03-01

    Full Text Available "n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 st1":*{behavior:url(#ieooui } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Alopecia areata, a non-cicatricial form of hair loss, is believed to be an immunologic response that targets hair follicles. Genetic background is important in the pathogenesis of this disorder, although some evidence point to the role of melanocytic antigens. There are some reports on the relationship between alopecia areata and celiac disease. The aim of the present study was to identify antigliadin antibodies in patients with alopecia areata. "n"nMethods: Fifty patients, aged 2.5-50 years, with alopecia areata presenting to the dermatology clinic of Razi Educational Hospital in Tehran, Iran, and fifty healthy individuals, aged 5-48 were matched and enrolled in the study. After signing an informed consent form, blood samples (10 ml clotted blood were obtained from the participants and sent to referral laboratory for the presence of antigliadin IgA and IgG antibodies. Concentrations of antibodies were measured by ELISA through a full automatic ELISA reader. The data were analyzed statistically."n"nResults: The study included 29(58% male and 21(42% female patients with a mean age of 24.6 years. The control group included 29(58% male and 21(42% female individuals with a mean age

  20. Fixação esquelética externa tipo Ia (unilateral-uniplanar para osteossíntese diafisária de úmero em pombos domésticos (Columba livia Type Ia (unilateral-uniplanar external Skeletal fixation for treatment of humeral diaphysis fracture in domestic pigeons (Columba livia

    Directory of Open Access Journals (Sweden)

    Alessandro Moraes Leotte

    2004-12-01

    Full Text Available Das várias patologias que podem acometer as aves, são mais freqüentes as fraturas de ossos longos das asas e dos membros pélvicos. Este experimento teve como objetivo observar, por meio de exames clínicos, histológicos e radiográficos, a resposta cicatricial óssea ao uso do fixador externo tipo Ia (unilateral-uniplanar na redução aberta de fratura diafisária, de úmero em pombos domésticos (Columba livia. Foram estudados 14 pombos com peso variando entre 290 e 420 gramas. A fratura foi realizada na diáfise do úmero direito e, logo após, estabilizada com aparelho de fixação externa tipo Ia, utilizando-se, como barra de fixação, o acrílico autopolimerizável. O tempo médio para o completo desaparecimento da linha de fratura foi de 28±6,44 dias e para formação de calo ósseo, 17±3,26 dias. As aves, mesmo com o aparelho de fixação, retornaram ao vôo aos 28±1,2 dias, exceto uma que não recuperou a capacidade de vôo. A técnica de fixação externa demonstrou ser eficaz para o tratamento de fraturas diafisárias de úmero em pombos domésticos.Among the various pathologies that can inflict birds, the long bones fractures of the wings, and pelvic members are more commom. Fourteeen domestic pigeons (Columba livia weighing 290 to 420g, were submitted to open reduction of humeral diaphysis fracture with external fixator type Ia (unilateral-uniplanar in order to evaluate the clinical, histological and radiographic evolution of the bone healing. The external fixator device was stabilized with methilmetacrylate acrylic. The average time necessary to the complete disappearance of the fracture line by radiographic evaluation was 28±6.44 days. The bone callus was identified at 17±3.26 postoperative days. The birds returned to flying in 28±1.2 days yet with the fixation device and only one did not recovere the flying abillity. The external fixation technique is an efficient method to treat diaphiseal humeral fracture in domestic

  1. Diagnostic and interventional radiology in the post-operative period and follow-up of patients after rectal resection with coloanal anastomosis.

    Science.gov (United States)

    Severini, A; Civelli, E M; Uslenghi, E; Cozzi, G; Salvetti, M; Milella, M; Gallino, G; Bonfanti, G; Belli, F; Leo, E

    2000-01-01

    was cured in 1 week. In 36 cases of cicatricial stenosis, 17 at the coloanal anastomosis and 19 at the pouch, radiological examination always detected the lesion, correctly defining its anatomical characterisitics, nature and extension. Of the 19 cases of stenosis treated radiologically, 15 recovered an adequate intestinal calibre for tients operated on, 21 cases of reccurrence were detected. Radiological examination was requested as the first investigation in only one of these cases, for a patient with subocclusion. Radiological investigations in patients who have undergone colonanal anastomosis are of read diagnostic value in the immediate post-operative period, during closure of the protective colostomy and in the follow-up of symptomatic recanalized patients. PMID:11003405

  2. Diagnostic and interventional radiology in the post-operative period and follow-up of patients after rectal resection with coloanal anastomosis

    Energy Technology Data Exchange (ETDEWEB)

    Severini, A.; Civelli, E.M.; Uslenghi, E.; Cozzi, G.; Salvetti, M.; Milella, M. [Department of Radiology, National Cancer Institute of Milan, via Venezian 1, I-23100 Milan (Italy); Gallino, G.; Bonfanti, G.; Belli, F.; Leo, E. [Department of Surgery, National Cancer Institute of Milan, via Venezian 1, I-23100 Milan (Italy)

    2000-07-01

    was cured in 1 week. In 36 cases of cicatricial stenosis, 17 at the coloanal anastomosis and 19 at the pouch, radiological examination always detected the lesion, correctly defining its anatomical characteristics, nature and extension. Of the 19 cases of stenosis treated radiologically, 15 recovered an adequate intestinal calibre for normal evacuation. During follow-up of the 175 patients operated on, 21 cases of recurrence were detected. Radiological examination was requested as the first investigation in only one of these cases, for a patient with subocclusion. Radiological investigations in patients who have undergone coloanal anastomosis are of real diagnostic value in the immediate post-operative period, during closure of the protective colostomy and in the follow-up of symptomatic recanalized patients. (orig.)

  3. Reconstituição experimental da parede torácica de gatos com implante heterógeno de cartilagem auricular conservada em glicerina a 98% Experimental reconstitution of the cat's thoracic wall with dog conchal cartilage implant preserved in 98% glycerin

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    Josaine Cristina da Silva Rappeti

    2003-12-01

    Full Text Available Com o objetivo de testar o implante de cartilagem auricular heteróloga conservada em glicerina a 98% como alternativa para reparar defeitos na parede torácica em felinos, foram estudados doze animais adultos, sendo distribuídos em dois grupos GI e GII, e avaliados após 60 dias de pós-operatório. Todos os animais foram submetidos à ressecção costal na porção média do tórax abrangendo a 7ª, 8ª e 9ª costelas e posterior implante de cartilagem conchal heteróloga conservada em glicerina a 98%. No GI, foi preservada a musculatura adjacente, já no GII, a musculatura foi retirada. Os animais foram avaliados clinicamente no pós-operatório e, ao final do período, submetidos à eutanásia e necropsia para avaliação macroscópica e microscópica da região do implante. Observou-se proliferação de tecido fibrovascular neovascularizado sobre o implante, com aderência pulmonar e diafragmática em algumas das unidades experimentais. O implante de cartilagem heteróloga conservado em glicerina a 98% pode ser utilizado para reconstrução de parede costal cujo defeito abranja o espaço de parte de três costelas. O implante em 60 dias é substituído por tecido cicatricial, sem apresentar sinais clínicos de rejeição.Twelve adult cats were divided in groups GI and GII with the objective of testing a dog auricular cartilage implant conserved in 98% glycerin as an alternative to repair thoracic wall defects. All animals were submitted to a resection of the medial portion of the thorax by removal of the 7th, 8th and 9th ribs and posterior cartilage implantation. GI had the adjacent musculature preserved and in GII cat's had it removed. The animals were clinically evaluated in the post operative period and after sixty days submitted to euthanasia for microscopic evaluation of the implanted local. Proliferation of granulation tissue and neomorph over the implant was observed in all animals and some had lung and diaphragm adherence. The

  4. Avaliação dos fatores de risco no linfedema pós-tratamento de câncer de mama Risk factors for breast cancer related lymphedema

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    Laura Ferreira de Rezende

    2010-12-01

    Full Text Available A principal complicação tardia no pós-operatório de câncer de mama é o desenvolvimento do linfedema, uma doença crônica, progressiva, geralmente incurável. O aumento do volume do membro pode desfigurar a imagem corporal, assim como aumentar a morbidade física e psicológica da paciente, além de promover significativo prejuízo para as funções. O presente estudo foi desenvolvido por meio de uma revisão sistemática a partir do cruzamento aleatório das palavras-chave: "linfedema", "compensações linfáticas", "sistema linfático", "dissecção axilar", "fatores de risco" e "câncer de mama". Foram selecionados 18 artigos entre os anos de 1979 e 2009, nos quais foram encontrados como principais fatores de risco para o desenvolvimento do linfedema a radioterapia, radioterapia axilar, infecção, dissecção axilar seguida de radioterapia, obesidade, número de linfonodos retirados e comprometidos e agressividade da cirurgia. As formas de compensação linfática após a dissecção axilar, como as anastomoses linfo-linfáticas, podem ser prejudicadas pela formação cicatricial, seroma pós-operatório, radioterapia e exercícios inadequados para reabilitação de ombro no câncer de mama.The main late complication after the surgery of breast cancer is the development of lymphedema, a chronic, progressive, usually incurable disease. The increase in the volume of the limb can disfigure the body image and develop the physical and psychological morbidity of the patient, promoting significant damage to the functions. This study was developed through a systematic review from the randomized crosschecking of the keywords "lymphedema", "lymphatic compensation", "lymphatic system", "axillary dissection", "risk factors" and "breast cancer". Eighteen articles were selected, between 1979 and 2009, in which radiotherapy, axillary radiation, infection, axillary dissection followed by radiotherapy, obesity, number of removed and impaired lymph

  5. Experimental study on operative methods of pancreaticojejunostomy with reference to anastomotic patency and postoperative pancreatic exocrine function

    Institute of Scientific and Technical Information of China (English)

    Ming-Dong Bai; Liang-Qun Rong; Lian-Chen Wang; Hai Xu; Rui-Fang Fan; Pei Wang; Xiao-Peng Chen; Liu-Bin Shi; Shu-You Peng

    2008-01-01

    AIM: To assess the patency of pancreaticoenterostomy and pancreatic exocrine function after three surgical methods. METHODS: A pig model of pancreatic ductal dilation was made by ligating the main pancreatic duct. After 4 wk ligation, a total of 36 piglets were divided randomly into four groups. The piglets in the control group underwent laparotomy only; the others were treated by three anastomoses: (1) end-to-end pancreaticojejunostomy invagination (EEPJ); (2) end-to-side duct-to- mucosa sutured anastomosis (ESPJ); or (3) binding pancreaticojejunostomy (BPJ). Anastomotic patency was assessed after 8 wk by body weight gain, intrapancreatic ductal pressure, pancreatic exocrine function secretin test, pancreatography, and macroscopic and histologic features of the anastomotic site. RESULTS: The EEPJ group had significantly slower weight gain than the ESPJ and BPJ groups on postoperative weeks 6 and 8 (P < 0.05). The animals in both the ESPJ and BPJ groups had a similar body weight gain. Intrapancreatic ductal pressure was similar in ESPJ and BPJ. However, pressure in EEPJ was significantly higher than that in ESPJ and BPJ (P < 0.05). All three functional parameters, the secretory volume, the flow rate of pancreatic juice, and bicarbonate concentration, were significantly higher in ESPJ and BPJ as compared to EEPJ (P < 0.05). However, the three parameters were similar in ESPJ and BPJ. Pancreatography performed after EEPJ revealed dilation and meandering of the main pancreatic duct, and the anastomotic site exhibited a variable degree of occlusion, and even blockage. Pancreatography of ESPJ and BPJ, however, showed normal ductal patency. Histopathology showed that the intestinal mucosa had fused with that of the pancreatic duct, with a gradual and continuous change from one to the other. For EEPJ, the portion of the pancreatic stump protruding into the jejunal lumen was largely replaced by cicatricial fibrous tissue. CONCLUSION: A mucosa-to-mucosa pancreatico

  6. Reconstrucción de nariz y labios en secuela de quemadura eléctrica Reconstrução de nariz e lábios em seqüela de queimadura elétrica Nose and lips reconstruction in electrical burn sequela

    Directory of Open Access Journals (Sweden)

    F.A.M. Cido Carvalho

    2009-09-01

    Full Text Available Presentamos el caso de un paciente joven, víctima de quemadura eléctrica en la cara, con complejas secuelas en la zona de boca y nariz, pérdida de sustancia y de parte del componente cartilaginoso de dorso, punta, colmuela y alas nasales, además de pérdida de labio superior e inferior, e importantes retracciones cicatriciales en áreas de vecindad. Fue sometido a reparación quirúrgica de la pérdida de sustancia nasal mediante colgajos supratrocleares y a reconstrucción de labio superior e inferior mediante colgajo cervical bipediculado, según descripción de Tsur y col. El resultado fue una buena cobertura nasal y la reconstrucción de los labios preservando sus funciones masticatorias y de habla, mejorando además la imagen estética del paciente.Caso de paciente jovem, vítima de queimadura elétrica na face, com complexas seqüelas na região da boca e nariz, como perda de substância cutânea e de parte do arcabouço cartilaginoso envolvendo dorso, ponta, columela e asas nasais, além de perda de lábios superior e inferior, com importante retração cicatricial das áreas vizinhas à lesão. Foi submetido a reparação da perda de substância nasal com retalhos supratrocleares e reconstrução dos lábios superior e inferior, através de retalho cervical bipediculado ao acaso, descrito por Tsur e cols. Resultou em boa cobertura nasal e reconstrução dos lábios, preservação das funções mastigatória e fala, além de permitir melhor figura estética ao paciente.We present a clinical case of a young man, victim of electrical burning to the face, with complex injuries to the mouth and nose. He presented cutaneous and framework damage to the nose and cutaneous damage to superior and inferior lips. He was submitted to nose repair with supratroclear flaps and mouth repair with bipedicular randomlybased cervical flap according to Tsur et al. The treatment allowed satisfactory nose cover and lips reconstruction, improvement on

  7. EFEITO DO DICLOFENACO DE SÓDIO NA CICATRIZAÇÃO DA PAREDE ABDOMINAL DE RATOS

    Directory of Open Access Journals (Sweden)

    JOÃO RICARDO F. TOGNINI

    1998-07-01

    Full Text Available O objetivo deste trabalho foi avaliar o efeito do diclofenaco de sódio na cicatrização da parede abdominal de ratos. Foram utilizados 40 (quarenta ratos machos Wistar, submetidos a laparotomia com técnica padronizada, distribuidos em dois grupos, um grupo controle e outro onde se administrou o diclofenaco de sódio - 3 mg/kg/dia, via intramuscular durante 4 (quatro dias consecutivos. Ao sétimo e ao décimo quarto dias de pós operatório, respectivamente, fora realizada a eutanásia, retirando-se a camada músculo-facial abdominal envolvendo a cicatriz operatória para a realização do estudo histológico. Os segmentos foram corados por Hematoxilina-Eosina e Picrosirius Red F3BA, sendo feita observação qualitativa do processo cicatricial e quantitativa do colágeno. Os resultados encontrados foram analisados estatisticamente. Concluiu-se que a cicatriz da parede abdominal de rato tratado com o diclofenaco de sódio apresenta menor quantidade de fibras colágenas no 7° e 14° dias de pós-operatório, quando comparado a animal do grupo controle.The aim of the experiment was to do a valuation of the effect of the sodium diclofenac on the collagenous sinthesis in abdominal wall healing. It was used 40 male Wistar rats to do longitudinal laparotomies with a standardized technique, divided into 2 groups: One without the drug (control group and another group wich were administrated sodium diclofenac (3mg/kg every day for 4 days. In the 7th and 14th postoperative day, 10 animals of each group were submitted to euthanasia and the front abdominal wall involving the scar was removed to be prepared to hystological analysis. The segments were prepared with Hematoxilyn-Eosin and Picrosirius Red F3BA, in order to do either a general view of healing process or a quantitative valuation of collagenous. The resultant data were submitted to statistical analysis. It was conclued that the abdominal wall scar in rats treated with sodium diclofenac had less

  8. Líquido amniótico tópico: uma potencial nova alternativa para doenças da superfície ocular Topical amniotic fluid: a potential new alternative for ocular surface diseases

    Directory of Open Access Journals (Sweden)

    Guilherme Goulart Quinto

    2008-12-01

    Full Text Available O líquido amniótico banha o feto durante a vida intra-uterina e está em contato permanente com a superfície ocular durante este importante período do desenvolvimento. Ele contém uma série de fatores de crescimento que podem ter diversos efeitos sobre o processo cicatricial. Estes fatores aceleram a recuperação da sensibilidade corneana e regeneração nervosa após procedimentos cerato-refrativos, além de controlar a formação de cicatriz e o equilíbrio da superfície ocular após sua aplicação tópica. Centenas de diferentes proteínas têm sido identificadas no líquido amniótico humano e o papel de cada uma continua desconhecido. Os resultados obtidos até o momento sobre a aplicação de líquido amniótico em doenças de superfície ocular sugerem uma terapia promissora. Pesquisas estão sendo realizadas para identificar os efeitos dos fatores específicos do líquido amniótico sobre a inflamação ocular. O objetivo desta revisão é relatar as propriedades e utilizações atuais do líquido amniótico, bem como apresentar os recentes estudos relacionados ao uso deste líquido e doenças da superfície ocular.Amniotic fluid bathes the fetus during intrauterine life and is in permanent contact with the fetal ocular surface in this important period of development. It contains a series of growth factors that may have multiple effects on the wound healing process. These factors are thought to accelerate the recovery of corneal sensitivity and nerve regeneration after keratorefractive procedures, and also may control scar formation and balance the ocular surface after topical application. Hundreds of different proteins have been identified in the human amniotic fluid, and the role of each still not quite understood. The outcomes obtained so far with amniotic fluid application to ocular surface diseases suggest a promising therapy. Research is underway to identify the effects of specific factors of the amniotic fluid in ocular

  9. Choroidal neovascularization associated with sympathetic ophthalmia: case report Neovascularização coroidiana associada à oftalmia simpática: relato de caso

    Directory of Open Access Journals (Sweden)

    Raul Nunes Galvarro Vianna

    2005-06-01

    Full Text Available A 7-year-old boy with sympathetic ophthalmia secondary to penetrating ocular trauma developed choroidal neovascularization in the macular region of the sympathizing eye. Posterior segment biomicroscopy disclosed a single, round, small, slightly elevated yellow-white lesion temporal to the fovea, linked to the temporal edge of the optic disc by a fibrotic band. On fluorescein angiography the round lesion showed a gradual hyperfluorescence, with late staining and leakage, and was interpreted as a fibrovascular scar from previous choroidal neovascularization. Despite intense immunosuppressive therapy, the patient's final visual acuity was 20/400. Although rarely associated with sympathetic ophthalmia, choroidal neovascularization and its cicatricial stages can occur and compromise the visual prognosis of an already debilitated eye. The best course of treatment for choroidal neovascularization in these types of cases has not yet been determined.Paciente com oftalmia simpática (OS desenvolveu neovascularização coroidiana (NVC na região macular do olho simpatizado. A biomicroscopia do segmento posterior do olho afetado revelou uma pequena lesão branco-amarelada, discretamente elevada, localizada na região temporal à fóvea. Uma banda fibrosa ligava o disco óptico à lesão foveal. À angiografia fluoresceínica, a lesão revelou hiperfluorescência progressiva, com impregnação e extravazamento tardio do corante, achados esses característicos de uma cicatriz fibrovascular. Apesar de intenso tratamento com medicação imunossupressora, a acuidade visual final do paciente foi de 20/400. Embora raramente associada à oftalmia simpática a neovascularização coroidiana pode ocorrer e comprometer o prognóstico visual de um olho já debilitado. A melhor opção para o tratamento da neovascularização coroidiana em casos de oftalmia simpática ainda não está determinada.

  10. Síntese da parede abdominal: avaliação de dois tipos de sutura contínua em ratos

    Directory of Open Access Journals (Sweden)

    Loureiro Vanessa Medeiros

    2003-01-01

    Full Text Available OBJETIVO: Comparar a sutura simples contínua e a sutura contínua em oito vertical no fechamento da parede abdominal de ratos. MÉTODOS: Quarenta e oito ratos machos Wistar, foram submetidos a laparotomia padronizada e fechamento da parede abdominal com sutura simples contínua (n=24 e sutura contínua em oito-vertical (n=24, com fio de polipropileno. No 7° e 14° pós-operatório foram submetidos a eutanásia 12 animais de cada grupo e deles retirados a camada músculo-aponevrótica da parede abdominal envolvendo a cicatriz operatória e preparados para exames histológico e imunohistoquímico. Os segmentos levados ao exame histológico foram corados por Hematoxilina-eosina sendo feita observação qualitativa do processo cicatricial e Picrosirius red F3BA, para avaliação quantitativa do colágeno. Também foram estudadas as porcentagens de macrófagos na linha de sutura por imunohistoquímica. Para a quantificação de macrófagos e fibras colágenas foi utilizado avaliação histológica por digitalização de imagem, baseados nos princípios de espectrofotometria. Os dados encontrados foram analisados estatisticamente pelos testes qui-quadrado, exato de Fisher e Mann-Whitney (p< 0,05. RESULTADOS: A análise qualitativa, nos parâmetros necrose, fibrose, neovascularização, presença de abscesso, reação de corpo estranho e coaptação das bordas de sutura, não mostrou dados significantes nos dois grupos aos 7 ou 14 dias. A porcentagem de fibras colágenas foi significantemente maior, apenas no 7° dia, na sutura contínua em oito-vertical. A porcentagem de macrófagos mostrou-se significantemente maior na sutura simples contínua no 7º. dia. CONCLUSÃO : No 7° dia de pós-operatório a parede abdominal suturada em oito vertical apresenta significantemente, maior quantidade de fibras colágenas e menor quantidade de macrófagos do que a suturada por técnica contínua. Aos 14 dias de observação as suturas mostraram

  11. Clinical Analysis of 30 Cases of Primary Incision plus HGH Soluble Hemostatic Gauze in Treating Perianal Abscess%一次切开术结合HGH溶解止血纱布治疗肛周脓肿30例

    Institute of Scientific and Technical Information of China (English)

    苗为民

    2014-01-01

    目的探讨一次切开术结合HGH溶解止血纱布(以下称止血纱布)在治疗肛周脓肿中的疗效。方法自肛缘沿脓肿顶部两侧呈放射状梭形切开脓肿,寻找内口并切开,清理脓腔,止血纱布填塞脓腔,术后抗菌素应用,每日便后清洗换药,重新填塞止血纱布至痊愈。结果30例患者均治疗一次痊愈。结论一次切开术结合止血纱布治疗肛周脓肿具有疼痛轻,创面生长快,并发症少,病程短等特点;在本组病例中患者无明显疼痛、创面渗液少、脓腔生长快、无1例术后出血、无1例瘢痕挛缩、无1例肛门狭窄及失禁;术后随访1年,无1例复发。%Probe into the medical ef ect of single incision with HGH gauze in treating perianal abscess. Methods Start incision from the top of abscess, search for a inside access and cut, clean the abscess, pack HGH gauze, use antibiotic after operation, clean the incision and reuse of antibiotic after daily excretion, repack HGH gauze til completely cured. Results Al 30 patients were completely cured by only single treatment. Conclusion The single incision with HGH gauze in treating perianal abscess has following advantages: less pain, less liquid excretion and quick recovery of operation surface. There is no case showing cicatricial contracture, anus stenosis and incontinence of feces. And there is no case of relapse during postoperative fol ow-up for 1 year.

  12. Clinical application of temporal flap pedicled with orbicularis oculi muscle%颞侧眼轮匝肌蒂岛状皮瓣的临床应用

    Institute of Scientific and Technical Information of China (English)

    梁伟强; 张金明; 潘淑娟; 陈宇宏; 储海函

    2008-01-01

    目的 探讨用颞侧眼轮匝肌蒂岛状皮瓣修复眼睑及鼻部皮肤软组织缺损的方法及效果.方法 设计以眼轮匝肌为蒂,以同侧颞区无毛发区为供区的皮瓣,移位并修复上下睑外翻及上下睑和鼻部肿瘤或瘢痕切除后、鼻外伤组织缺损共30例.皮瓣面积为1.0 cm×1.8 cm~2.5 cm×4.5 cm.结果 30例巾除5例早期皮瓣远端出现静脉淤血经保守治疗好转外,全部皮瓣均完全成活,随访3个月至1年,较少遗留瘢痕及继发畸形,功能及外观满意.结论 以眼轮匝肌为蒂的颞侧岛状皮瓣是修复眼睑及鼻部小面积缺损的良好手术材料,具有易于转移、血供可靠、愈合快及供区隐蔽等优点.%Objective To investigate the effect of repairing soft tissue defect of eyelid and nose by using temporal flap pedicled with orbicularis oculi muscle.Methods From 2000,the temporal flaps pedicled with orbicularis oculi muscle were used in 30 cases,including cicatricial ectropion of upper and lower eyelid,tumor or scar in eyelid and nose area,nose tissue defect after injury.The maximal area of skin flap was 1.0 cm×1.8 cm~2.5 cm×4.5 cm.Results All the skin flaps were survived after operations except 5 cases which had problems with venous refluence on the distal part of skin flaps and were improved after conservative treatments.Cases were followed up from 3 months to 1 year,and there were few scars or secondary deformity formation in the donor site.The function and appearance were satisfied.Conclusions The temporal flap pedicled with orbicularis oculi muscle is a reliable material to repair small soft tissue defect of eyelid and nose with easily transferring capacity,reliable blood supply,rapid healing ability and concealed donor site.

  13. Application of biological dural graft made by meninges from porkers

    Institute of Scientific and Technical Information of China (English)

    Peng Liu; Shengping Huang; Songtao Qi

    2007-01-01

    sections were observed. White blood cells in venous blood were counted before operation and execution, separately. The obtained data were statistically analyzed.MAIN OUTCOME MEASURES: ① Wound healing and recovery following implantation of dural graft.②The amount of white blood cells in venous blood from rabbits at each time point before operation and before execution. ③ Histological examination results of operative site.RESULTS: Sixteen experimental rabbits were involved in the final analysis. ① The experimental rabbits of each group had no local infection, effusion and abnormal appearance. They had good wound healing and were normal to access to food. ② There were no significant differences in amount of white blood cells in venous blood from experimental rabbits between at each time point after modeling and before operation (P >0.05). ③Pathological observation of operative site: At postoperative 3 days, local acute inflammation repair reaction appeared; At postoperative 2 weeks, chronic inflammatory reaction appeared, endodermis in artificial dural graft formed, and artificial dural graft and host dura mater healed; In postoperative 1 month,wound began to chronically recover; In postoperative 3 months, host blood capillary began to form in artificial dural graft based on chronic repair. In all the control sides, fibroplasia was found, and a few neutrophils were found at postoperative 2 weeks.CONCLUSION: Biological surgical patch has high stability and good histocompatibility. It can provide dural epithelial epithelium, effectively prevent against the conglutination of scalp tissue and brain tissue, and avoid the leakage of cerebrospinal fluid.

  14. 多发性骨髓瘤基因修饰瘤苗诱导体内抗肿瘤反应的实验研究%Genetically Modified Myeloma Cell Vaccine Inducing Antitumor Immune Response in vivo

    Institute of Scientific and Technical Information of China (English)

    任素萍; 王立生; 郭强; 王华; 贾向旭; 徐娟; 王恒湘; 吴祖泽

    2006-01-01

    本研究目的是评价NOD/SCID小鼠皮下移植瘤模型对多发性骨髓瘤基因修饰瘤苗引发体内抗肿瘤反应的效果.首先给NOD/SCID小鼠腹腔注射人外周血淋巴细胞以在其体内重建人的免疫系统,然后皮下接种γ-射线灭活的基因修饰骨髓瘤细胞sko-007(表达绿色荧光蛋白或者p53、GM-CSF和B7-1基因),以PBS作为对照,最后植入活sko-007细胞进行攻击.结果发现,与对照组相比接种感染腺病毒Ad-p53/GM-CSF/B7-1的sko-007细胞可以明显抑制移植瘤生长,病理分析显示移植瘤纤维组织增生伴弥漫性坏死增多,血管增生显著.免疫组织化学染色显示瘤灶内有人T淋巴细胞浸润.结论:p53、GM-CSF和B7-1基因修饰的骨髓瘤细胞能够诱导产生抗肿瘤免疫反应,有可能用于人类多发性骨髓瘤的免疫治疗.%This study was aimed to evaluate the in vivo antitumor effect of genetically modified myeloma cell vaccine on human myeloma xenografts implanted into nonobese diabetic/severe combined immunodeficiency (NOD/SCID)mice. Human immune system was established in NOD/SCID mice by intraperitoneal injection of human peripheral blood lymphocytes (PBLs). After being inoculated subcutaneously with irradiated myeloma cell line sko-007, adenovirally transferred with GFP or p53, granulocyte-macrophage colony-stimulating factor (GM-CSF) and B7-1 genes, huPBLNOD/SCID mice were challenged by subcutaneous injection of non-transferred sko-007 cells. The results indicated that Ad-p53/GM-CSF/B7-1-infected sko-007 cell vaccination significantly reduced local tumor growth compared with controls. Histopathological and immunohistochemical analysis showed that tumor tissues increasingly displayed diffuse necrosis, mainly caused by apoptosis, accompanied with significant fibroplasias and blood vessel hyperplasia, and human T cells infiltrated into the tumor tissues. It is concluded that transgenic p53, GM-CSF and B7-1 expression produces an immune response

  15. Characteristics of lung functional lesion and pathological variation in patients undergoing coal - burning arsenic poisoning%燃煤型砷中毒患者肺功能损害与病理改变的特征

    Institute of Scientific and Technical Information of China (English)

    杨运旗; 陈吉; 孙兰英; 陈宁; 张爱华

    2012-01-01

    under the optical microscope. Type Ⅱ alveolar epithelial cell degeneration, necrosis, shedding and decreasing of number were observed under the electron microscope, and hyperplasia of collagen fiber was obvious. Conclusion Restrictive ventilation function disturbance is the main clinical type of lung functional changes in patients undergoing coal - burning arsenic poisoning, which has close correlation with the pathological changes such as fibroplasias in pulmonary interstitium,thickening of pulmonary interstitium,decreasing of elasticity in lung issue caused by edema of alveolar wall and damage in type Ⅱ alveolar epithelial cell.

  16. Cistoplastia experimental em coelhos (Oryctolagus cuniculus com peritônio bovino conservado em glicerol a 98% Experimental cystoplasty in rabbits (Oryctolagus cuniculus with bovine peritoneum conserved in 98% glycerol

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    Tatiana Catelan de Oliveira

    2008-11-01

    Full Text Available Neste estudo foi implantado um retalho de membrana peritoneal bovina em substituição a um fragmento da face ventral da bexiga de coelhos albinos, raça Nova Zelândia, adultos, machos não-castrados (n=12, com o intuito de avaliar o processo de reparação tecidual no que se refere à biocompatibilidade, à capacidade de reparação tecidual e a possíveis complicações. Aos sete, 14, 30 e 60 dias de pós-operatório, os animais foram eutanasiados, três em cada período, mediante o emprego de tiopental sódico (200mg kg-1, para posterior avaliação macroscópica e análise histopatológica da interface do implante com o tecido nativo. Macroscopicamente, foram observadas, em todos os períodos, aderências de estruturas adjacentes ao local do implante, presença de cálculos e ausência de sinais de rejeição. Sob microscopia de luz, aos sete, 14 e 30 dias de observação, o implante ainda estava presente, havia intensa reação inflamatória mista, neovascularização, fibroplasia e escassas fibras musculares, contudo, o epitélio e a lâmina própria não estavam reconstituídos. Aos 60 dias de avaliação, o implante não estava mais presente e todas as camadas vesicais encontravam-se reparadas. O implante foi biocompatível e forneceu arcabouço para orientação e desenvolvimento das camadas teciduais da bexiga, mediante processos de reparação, restabelecendo a estrutura do órgão.Bovine peritoneum was utilized to replace a section of ventral face of the bladder of New Zealand rabbits, adult and entire males (n=12 with the purpose of evaluating the tissue repair process in regard of its biocompatility, scar formation ability and possible complications. The animals were euthanized at 7, 14, 30 and 60 days post operative, three in each period, by the use of sodium thiopental (200mg kg-1, followed by macroscopic evaluation and histopathological analysis of the implant interface with the native tissue. Macroscopically it was observed

  17. Crecimiento maxilar según severidad de hendidura labial, alveolar y palatina unilateral Maxillary growth according to the severity of unilateral cleft lip and palate

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    M.C. Navas-Aparicio

    2012-12-01

    Full Text Available La inhibición del crecimiento y desarrollo resultante del tratamiento quirúrgico en pacientes con labio y paladar hendido es un tema ampliamente discutido en el mundo. De acuerdo a la literatura, la deficiencia de tejidos, probablemente debida al ancho y la posición del segmento alveolar en la hendidura, es una variable a considerar que afecta al crecimiento del maxilar, el cual también puede verse influido por la corrección quirúrgica del labio, la nariz y el paladar, por tejido cicatricial, los diferentes tipos de tratamiento quirúrgico, el tiempo de cirugía, la habilidad del cirujano y la ortopedia prequirúrgica. El propósito de este estudio es determinar la posible asociación entre la severidad de la hendidura y el crecimiento maxilar en niños con labio y paladar hendido unilateral no sindrómico nacidos en el año 2001 y atendidos en el Hospital Nacional de Niños "Dr. Carlos Sáenz Herrera", Caja Costarricense de Seguro Social de San José, Costa Rica. El estudio fue de tipo retrospectivo y descriptivo, basado en datos recopilados de registros médicos, modelo inicial de escayola del maxilar del niño recién nacido, radiografía cefalométrica y modelo actual del maxilar del niño a la edad de 5 años. La muestra de estudio comprendió 13 pacientes. La dimensión transversal del arco fue asimétrica en 12 casos, lo que indica alteración del crecimiento en esta dirección. Existe una correlación positiva estadísticamente significativa entre la longitud del arco y el ángulo SNA, indicando que a mayor longitud de arco, el ángulo SNA es mayor. El valor promedio de ANB tiene una desviación importante superior a 2. No existe relación entre la posición y longitud del arco maxilar (SNA, BaNA y ANS-PNS y la severidad de la hendidura. Esto significa, que el tejido cicatricial, el tipo de tratamiento quirúrgico, el tiempo de cirugía, el cirujano, la habilidad del cirujano y la ortopedia prequirúrgica, no influyen en la direcci

  18. Estudo retrospectivo da utilização do transplante de membrana amniótica em um serviço terciário de Oftalmologia Retrospective study of amniotic membrane transplantation in a terciary ophthalmic health care service

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    Eduardo Conforti de Oliveira

    2008-08-01

    Full Text Available OBJETIVO: Nos últimos anos , o transplante de membrana amniótica (MA tem sido utilizado com freqüência na reconstrução da superfície ocular em diversas doenças oculares. Este estudo objetiva identificar as indicações mais freqüentes do transplante de MA, assim como avaliar os resultados deste procedimento. MÉTODOS: Foram analisados retrospectivamente os prontuários de 107 pacientes submetidos ao transplante de MA, avaliando a indicação do transplante de MA e a evolução do quadro no período pós-operatório. RESULTADOS: Dos 107 pacientes estudados, as indicações de MA mais freqüentes foram exérese de pterígio 33.64%(n=36, defeito epitelial persistente 29.90%(n=32, liberação de simbléfaro 18.69%(n=20, queimadura química 6.54%(n=7, cérato-conjuntivite primaveril 4.67%(n=5, síndrome de Stevens-Johnson 2.80%(n=3, penfigóide ocular cicatricial 1.86%(n=2, ceratopatia bolhosa 1.86%(n=2. No seguimento dos pacientes houve recidiva do pterígio em (6.25% nos pterígios primários e em (15% nos pterígios recidivados. Não houve recidiva nos pacientes com simbléfaro, tendo como causa pterígio recidivado. Houve fechamento do epitélio com o uso de MA nos pacientes do estudo variando de 50 a 80%, dependendo da doença de base. Na fase aguda da queimadura química houve fechamento epitelial em 50% dos casos. Já nos que utilizaram MA na fase crônica da queimadura a restauração da superfície ocular ocorreu em 33% dos casos. Uso da MA na cérato-conjuntitivite primaveril com papilas gigantes, 80% não apresentaram recidiva das papilas.Todos os pacientes que tiveram indicação de MA, devido à ceratopatia bolhosa apresentaram diminuição da dor . Os pacientes que tiveram como causa da utilização de membrana a Síndrome de Stevens-Johnson (SSJ na fase aguda apresentaram diminuição importante do processo inflamatório . Dos pacientes que receberam enxerto de MA na fase crônica da SSJ, 50% apresentaram evolução favor

  19. Aspectos epidemiológicos da seneciose na região sul do Rio Grande do Sul Epidemiological aspects of seneciosis in southern Rio Grande do Sul, Brazil

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    Fernando Sérgio Castilhos Karam

    2004-12-01

    íquido nas cavidades. No fígado, a histopatologia revelou fibroplasia, megalocitose e proliferação de células dos ductos biliares e, no cérebro, degeneração da substância branca. Em amostras das diferentes espécies de Senecio, coletadas em diferentes épocas do ano, foi determinada a concentração de alcalóides pirrolizidínicos (APs e seus N-óxidos através de cromatografia de camada delgada e espectrofotometria. Retrorsina foi encontrada em Senecio brasiliensis, S. heterotrichius, S. selloi e S. oxyphyllus. Além deste, S. brasiliensis e S. heterotrichius registraram mais um e dois alcalóides não identificados, respectivamente. A maior concentração de AP reduzido (AP livre + N-óxido foi encontrada em S. brasiliensis no inverno (0,25%. Nessa mesma época quantidades decrescentes de AP reduzidos foram encontradas em S. heterotrichius (0,19%, S. oxyphyllus (0,03% e S. selloi (0,03%. Em S. leptolobus não foram detectados alcalóides. Esses dados demonstraram que S. brasiliensis é a espécie mais importante como causa de seneciose no sul do Rio Grande do Sul. Adicionalmente, foram analisados dados de arquivo do LRD sobre 54 surtos de intoxicação por AP no período 1978-1997. Nesse período, 7 (12,96% surtos afetaram bovinos menores de 3 anos, 39 (72,22% afetaram bovinos de 3 anos ou mais, 3 (5,55% afetaram bovinos de várias idades e, em 5 (9,25% surtos a idade não foi informada. Trinta e nove (72,22% surtos afetaram fêmeas, 7 (12,96% afetaram machos, 3 (5,55% afetaram ambos os sexos e, em 5 (9,25%, o sexo não foi informado. Vinte e três (42,59% surtos ocorreram na primavera, 9 (16,66% no verão, 9 (16,66% no outono, e 13 (24,07% no inverno. O maior número de surtos da intoxicação no período 1998-2000 (24 surtos em 3 anos em relação ao período 1978-1997 (54 surtos em 20 anos pode estar relacionado à diminuição em mais de 50% da população ovina no Estado.Seneciosis is the main cause of livestock mortality due to poisonous plants in the State

  20. Clinical analysis on intraoperative hemorrhage status of pernicious placenta previa patients%12例凶险性前置胎盘术中出血情况的临床分析

    Institute of Scientific and Technical Information of China (English)

    李秀彦; 茹美艳

    2012-01-01

    OBJECTIVE To investigate the reason and precautionary measures of massive haemorrhage during repeated cesare-an section in pregnancy patients with scar uterous and placenta previa. METHODS The clinical data of 15S parturients patients who undergoing cesarean section again from 2009 to 2011 were analyzed retrospectively, 12 cases of all patients were with placenta previa, 143 cases were without. RESULTS The rate of massive haemorrhage, placenta accreta and threatened uterine rupture in group re-cesarean section (who with cicatricial uterus and placenta previa) were higher respectively than those whitout placenta previa-lntraoperauve massive hemorrhage occured in S cases who with the central type placenta praevia, and 4 cases were placenta previa and threatened uterine rupture. CONCLUSION Antetheca central placenta praevia plus placenta implantation is a chief factor of massive hemorrhage of intraoperative cesarean section. Making good preoperalive preparations, such as uterine artery embolization (UAE), is significant for the outcome of pregnancy.%目的 探讨癜痕子宫伴前置胎盘(凶险性前置胎盘)再次剖宫产患者术中大出血的发生原因以及预防措施.方法 收集分析2009年9月~2011年11月某院行单胎再次剖宫产155例患者的临床资料,其中伴前置胎盘者12例(观察组),瘢痕子宫不伴前置胎盘143例(对照组).癜痕子宫伴前置胎盘者12例术中出血原因进行归纳总结分析.结果 癜痕子宫伴前置胎盘组合并中央性前置胎盘,胎盘植入、先兆子宫破裂均高于癜痕子宫不伴前置胎盘组.5例瘢痕子宫伴前置胎盘剖宫产术中大出血均为胎盘植入,且5例均为中央性前置胎盘,4例是前壁胎盘合并先兆子宫破裂.结论 前壁中央性前置胎盘合并胎盘植入是瘢痕子宫伴前置胎盘剖宫产术中大出血主要原因.术前做好相应预防措施,必要时做好子宫动脉栓塞准备,尽可能保留子宫,对妊娠结局非常重要.

  1. Ventajas de la cicatrización cutánea asistida por láser (LASH Advantages of laser assisted scar healing (LASH

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    S. Mordon

    2011-12-01

    Full Text Available La fase final de toda cirugía es la sutura y su cicatriz correspondiente y, frecuentemente, ésta es la única secuela visible de una intervención. La técnica LASH (cicatrización cutánea asistida por láser, estimula los mecanismos de reparación de la piel por efecto térmico, condicionando la calidad de la cicatrización. Estudios experimentales en ratones comparando los resultados obtenidos en heridas quirúrgicas radiadas con laser diodo 810 nm tras ser suturadas, con los obtenidos en igual tipo de heridas suturadas de manera convencional, han demostrado que se consiguen cicatrices mucho menos visibles cuando se practica el tratamiento con láser. La histología confirma, comparativamente, una notable aceleración del proceso cicatricial con modificación del TGFβ (Transforming Growth Factor-Beta directamente implicado en la reparación tisular, en los animales en los que la sutura fue asistida por láser. Igualmente, el análisis tensiométrico demostró mayor resistencia a la acción de estiramiento mecánico en estas heridas. Estudios clínicos en pacientes sometidos a dermolipectomia, reducción mamaria y estiramiento facial, demuestran que al tratar con LASH una parte o una de las líneas de sutura, los análisis realizados tanto por los pacientes como por cirujanos independientes a los 8 días, 3 meses y un año, evidencian resultados más favorables para la técnica láser, Las dosis eficaces determinadas para las fluencias láser están entre 80 y 120 J/cm². La técnica LASH es simple de efectuar, reproducible, rápida y ofrece una clara evidencia de que es posible reducir considerablemente la cicatriz, logrando que ésta sea de mejor calidad y más estética.Suture is the final stage of surgery and as a consequence, a scar is frequently the only visible effect after an operation. LASH technique (Laser Assisted Scar Healing produces thermal effects to stimulate mechanisms for tissue repair that will determine the quality of

  2. Measurement of the flexing force of the fingers by a dynamic splint with a dynamometer Medida da força de flexão dos dedos da mão através de órtese dinâmica com dinamômetro

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    Silmara Nicolau Pedro da Silva

    2005-10-01

    ça no tendão flexor diminui conforme aumenta o grau de amplitude articular. Observou uma relação entre o comprimento do dedo e a magnitude da força exercida no tendão durante a flexão do dedo, sendo que nos dedos mais compridos os tendões são submetidos a forças maiores. Quando comparou a estatura e envergadura com a magnitude da força aplicada no tendão flexor, observou uma relação positiva em todos os graus de flexão estudados, exceto a 30º. O sexo masculino apresentou maior força em todos os graus de amplitude articular. CONCLUSÕES: Conclui que é possível medir a força de flexão transmitida pelos tendões flexores através de uma órtese acoplada a um dinamômetro, que esta força é maior nos indivíduos do sexo masculino, com dedos mais longos, de maior altura e envergadura e que tais dados permitirão o desenvolvimento de futuros trabalhos no campo da reabilitação da mão, auxiliando pacientes portadores de lesões de tendões, retração cicatricial, deformidades e rigidez articular.

  3. Manejo del enoftalmos como secuela de fracturas del complejo cigomático-orbitario con apoyo de estereolitografía Management of enophtalmos as sequelae of zygomatic complex orbital fractures with stereolitography model support

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    H. Malagón Hidalgo

    2011-03-01

    Full Text Available El enoftalmos postraumático se define como la discrepancia entre el volumen orbitario y su contenido; este balance puede verse alterado por múltiples factores, como el secuestro tardío del contenido orbitario por atrapamiento en el sitio de la fractura, herniación del contenido orbitario, necrosis del tejido adiposo orbitario, contracción cicatricial del tejido retrobulbar, pérdida del sistema de suspensión ligamentario del globo ocular y aumento de volumen de la cavidad orbitaria. El presente estudio aborda el problema del enoftalmos postraumático como una deformidad difícil de corregir. Están descritos abordajes cutáneos extensos como el coronal, el subciliar o el intraoral; la técnica descrita por Henry Kawamoto en 1998 describe un procedimiento de menor invasión mediante abordajes de mínima exposición que permiten la refracturación y el alineamiento del cuerpo zigomático, brindando así grandes ventajas sobre las técnicas convencionales. Presentamos el método aplicado en el servicio de Cirugía Reconstructiva del Centro Médico del Instituto de Seguridad Social del Estado de México y Municipios (ISSEMyM para el manejo de pacientes con enoftalmos como secuela de traumatismos del complejo cigomático-malar; para ello empleamos un método por asistencia con modelos estereolitográficos para la planificación quirúrgica del diseño de osteotomías para corregir la deformidad facial y para determinar las dimensiones del defecto a reparar, así como el tipo y cantidad de materiales aloplásticos o autólogos a emplear. Compartimos la experiencia de los casos tratados en nuestro Servicio entre 2006 y 2010.Post-traumatic enophthalmos is defined as the discrepancy between the orbital volume and its content; this balance can be altered by many factors, such as the entrapment or herniation of the orbital content at the fracture site, orbital adipose tissue necrosis, scar contraction of the retrobulbar tissue, loss of the eyeball

  4. Técnica de cierre vertical en labio hendido: Reporte de 837 casos y revisión de la literatura Vertical closing in lip cleft: Report of 837 cases and review of the literature

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    J.A. León Pérez

    2008-09-01

    Full Text Available Ninguna otra deformidad congénita tiene el potencial de alterar la forma facial tan perceptiblemente como lo hace un labio y paladar hendido, en donde el tercio medio de la cara se modifica y supone un gran desafío para el cirujano plástico. Proponemos el cierre vertical de la piel tras la miorrafia, formando una línea y tratando de dar apariencia a la columna del filtrum que no se formó en el labio hendido. Presentamos el resultado en niños operados en el Servicio de Cirugía Plástica del Instituto Nacional de Pediatría de México DF desde enero de 1998 hasta diciembre de 2006, en total 837 pacientes. La técnica quirúrgica utilizada consistió en el cierre de labio hendido en forma vertical. Del total de pacientes, 310 fueron mujeres y 527 varones; el 13% (n=109 presentaban hendidura bilateral. El 95% de los pacientes (n= 795 tuvieron un resultado estético adecuado; no se presentaron complicaciones postoperatorias inmediatas y sólo en un paciente se produjo dehiscencia de la herida. Como ventajas de la técnica podemos citar el que produce una línea cicatricial que parece la columna del filtrum hendido, el que conlleva una disección anatómica de la piel (líneas de máxima tensión y el que evita las incisiones que cruzan el filtrum o el ala nasal, con lo que la cicatriz resultante es menos visible.No other congenital deformity has the potential to alter the face form as perceivably as it makes a cleft lip and palate. The middle third of the face is altered and it represents a great challenge for plastic surgeon. We propose the vertical closing of the skin after miorraphy forming a line and trying to appear like the filtrum column that was not formed in the cleft lip. We report the result in children operated on our Service of Plastic Surgery at the Instituto Nacional de Salud, México DF, from january 1998 to december 2006, total 837 patients. Surgical technique consisted of the closing of cleft lip in vertical way. Total number

  5. Use of castor oil polyurethane in an alternative technique for medial patella surgical correction in dogs Utilização do poliuretano de mamona em técnica alternativa de correção cirúrgica da luxação medial de patela em cães

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    Fabrício de Oliveira Frazilio

    2006-01-01

    -se em 5%, o nível de rejeição da hipótese de nulidade. RESULTADOS: Não foi observada interação óssea (osteointegração no grupo polímero de mamona. Houve reabsorção do enxerto ao longo do período experimental e ausência de células inflamatórias nos períodos analisados. CONCLUSÃO: O polímero de mamona auxiliou no processo cicatricial, foi biocompatível sem presença de inflamação, podendo ser usado em articulações como uma alternativa para o preenchimento ósseo.

  6. Cytokine profile of rats fed a diet containing shrimp Perfil das citocinas de ratos alimentados com dieta de camarão

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    Elizabeth Lage Borges

    2013-02-01

    Full Text Available OBJECTIVE: Studies have shown that shrimps reduced the tensile strength of scars in rat skin. The aim of the present study was to assess the cytokine profile of rats fed shrimp. METHODS: Group 1 (control received a regular diet and Group 2 (experimental received a diet containing 33% shrimp for nine days. The two diets contained the same amounts of proteins, fats and carbohydrates. Serum cytokine levels were determined by ELISA and a segment of the jejunum was taken to investigate its histological morphology and eosinophil infiltrate. RESULTS: The experimental group had lower serum levels of interleukin-4 (IL-4 (14.4±1.9 versus 18.11±2.6pg/mL; pOBJETIVO: Estudos mostraram que a dieta suplementada com camarão reduziu a resistência cicatricial na pele de ratos. Nesse contexto, o objetivo do presente estudo foi avaliar o perfil das citocinas de ratos que receberam dieta adicionada com camarão. MÉTODOS: Foram comparados um grupo controle e um grupo experimental, que receberam uma dieta enriquecida com camarão (33% durante nove dias. As duas dietas continham quantidades semelhantes de proteínas, lipídeos, e carboidratos. Os níveis séricos de citocinas foram avaliados por ELISA, assim como um segmento de jejuno foi obtido para exame histológico da morfologia e infiltrado de eosinófilos. RESULTADOS: A dieta adicionada com camarão diminuiu os níveis séricos de IL-4 (14,4±1,9 versus 18,11±2,6pg/mL, p<0,05 e IL-10 (5,0±0,98 versus 7,5±1,2pg/mL, p<0,05 e aumentou os níveis séricos de IL-6 (3,2±0,4 versus 17,8±2,3pg/mL, p<0,001 quando comparada com os animais controle. Morfologicamente, a dieta adicionada com camarão causou uma desorganização da arquitetura da mucosa intestinal, juntamente com uma abundância de eosinófilos nas vilosidades jejunais. CONCLUSÃO: Os dados sugerem que a ingestão de dieta adicionada com camarão leva a um aumento significativo da citocina IL-6, juntamente com uma diminuição da citocina

  7. Restauração do diafragma de felino com enxerto autólogo de pericárdio Reconstruction of feline diaphragm with autologous pericardium graft

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    Saulo Tadeu Lemos Pinto Filho

    2003-10-01

    Full Text Available OBJETIVO: Avaliar o uso de enxerto autólogo de pericárdio para correção de defeitos diafragmáticos em felinos. MÉTODOS: Foram utilizados doze gatos domésticos, adultos, sem raça definida, pesando entre dois e quatro quilogramas. O procedimento cirúrgico consistiu de toracotomia no 7º espaço intercostal esquerdo, remoção de um retalho do pericárdio de, aproximadamente, 2,0 x 4,0 cm e sutura desse em um defeito de tamanho aproximado criado no diafragma. Cinco animais foram observados por um período de 30 dias de pós-operatório e o restante em 60 dias, quando foram submetidos à eutanásia para observação macroscópica e coleta de amostras para avaliação histológica. RESULTADOS: Foi observada nos animais do grupo de 30 dias, substituição parcial e no grupo de 60 dias, substituição total do enxerto de pericárdio por tecido fibrovascular, permitindo o restabelecimento completo do diafragma. Macroscopicamente, foi verificada presença de aderência na cavidade torácica, com o pulmão e pleura parietal e, na cavidade abdominal, com o fígado e omento, porém, sem comprometimento clínico das estruturas envolvidas. CONCLUSÃO: O enxerto autólogo felino pode ser utilizado para reparação de defeitos diafragmáticos, pois suporta a diferença de pressão presente, sendo substituído por tecido cicatricial, sem apresentar sinais clínicos e histológicos de rejeição.PURPOSE: Evaluate the use of feline autologous pericardium to correct diaphragmatic defects. METHODS: Twelve male and female, adult, mixed breed, domestic cats were used weighing between 2 and 4 kilogram. The surgical procedure consisted of thoracotomy of the 7th left intercostal space, removal of a pericardium graft of approximately 2,0 x 4,0 cm and the graft was sutured in a defect of the same size in the diaphragm. Six animals were observed for a period of 30 days postoperatively and six for 60 days. After this period they were submitted to euthanasia for

  8. 指固有动脉不同节段背侧皮支为蒂的岛状皮瓣修复同指皮肤缺损%Application of island flap pedicled with dorsal cutaneous branches of digital internal artery for skin defect at the same finger

    Institute of Scientific and Technical Information of China (English)

    阚利民; 陈超; 张会文; 刘建华

    2010-01-01

    目的 探讨以指固有动脉不同节段背侧皮支为蒂的岛状皮瓣修复同指皮肤及软组织缺损的临床效果.方法 2005年6月至2008年6月,对45例52指手指皮肤缺损的患者,采用以指固有动脉背侧皮支为蒂的岛状皮瓣转移修复.结果 45例中除4指皮瓣远端部分坏死外,其余皮瓣全部成活,经4~8个月随访,功能及外观良好.吻合神经皮瓣的两点辨别觉为6.0~9.0 mm,平均7.4 mm.未吻合神经的皮瓣的两点辨别觉为8~10 mm,平均9 mm.植皮区无明显凹陷,5指轻度色素沉着,4指出现植皮边缘瘢痕挛缩,其中1指远侧指间关节约10°伸直受限,经理疗后未见缓解.2指出现供区瘢痕触痛,经理疗后部分缓解.在常温下和冰水中均未出现苍白、发凉.供指指腹感觉均为S_4.手功能按ATM法,优42指,良7指,可3指,优良率达92%.结论 该术式不损伤手指的主要动脉,是治疗手指皮肤缺损的一种可行的手术方法.%Objective To investigate the therapeutic effect of island flap pedicled with dorsal cutaneous branches of digital internal artery for skin defect at the same finger. Methods From June 2005 to June 2008, 52 fingers in 45 cases with skin defects were treated with island flap pedicled with dorsal cutaneous branches of digital internal artery for skin defect at the same finger. Results Partial necrosis happened at the distal end of 4 island flaps. All the other flaps survived completely. The patients were followed up for 4-8 months with satisfactory cosmetic and functional results. The two-points discrimination distance was 6. 0-9.0mm ( average, 7.4 mm) in flaps with nerve anastomosis, and 8-10 mm (average, 9mm) in flaps without nerve anastomosis. Minor pigmentation occurred in 5 fingers, cicatricial contracture around the skin graft in 4 fingers, and pain in donor site scar in 2 fingers. The hand function was assessed as excellent in 42 fingers, as good in 7 fingers and medium in 3 fingers. Conclusions The

  9. 低旋转点外踝上皮瓣修复前足创面的临床应用%Clinical Application of Sub-pivoting Point Extramalleolus Epithelial Skin Flap in Repalring Soft Tissue Defects of the Forefoot

    Institute of Scientific and Technical Information of China (English)

    沈强; 李仲影; 王晓琴; 景晓虎; 吕杰

    2012-01-01

    Objective To explore the clinical effect of sub-pivoting point extramalleolus epithelial skin flap in repairing the soft tissue defects of the forefoot. Methods 39 patients with the soft tissue defects in forefoot admitted during March 2007 and May 2010 were traumatic soft tissue loss in proleg, 13 patients combined with injury of the bone and joint. Ordinary debride-ment was done and integrity of anterior and posterior tibial artery was assured. We designed the skin flap and used sub-pivoting point extramalleolus epithelial skin flap in repairing defects. Results All the flaps survived. Veins articulo appeared at distal end of 1 patients skin flap 2 d after operation, and the skin flap was put back after demolishing suture line of skin of pivoting point. The distal skin necrosis occurred in 4 skin flaps, and secondary healing came after changing dressings. We observed appearance of skin flap, texture, pigmentation and cicatricial contracture 6 months-2 years postoperative. 9 patients'Cutaneous sensation bated due to intraoperative superficial peroneal nerve injury. Conclusion It is an effective method in repairing the soft tissue defects in the forefoot to cut sub-pivoting point extramalleolus epithelial skin flap.%目的 探讨低旋转点外踝上皮瓣在修复前足皮肤软组织缺损中的应用.方法 2007年3月-2010年5月收治前足皮肤软组织缺损39例,均为外伤性前足软组织缺损,合并骨与关节损伤13例.伤后常规清创,确定胫前动脉、胫后动脉是否完好,设计皮瓣并应用低旋转点外踝上皮瓣修复缺损.结果 所有皮瓣成活,1例术后2d皮瓣远端出现静脉危象,拆除旋转点处皮肤缝线后皮瓣恢复正常,4例皮瓣远端皮肤部分浅表性坏死,经换药处理后二期愈合.本组随访6个月~2年,皮瓣外观、质地优良,无色素沉着、瘢痕挛缩等情况,9例足背外侧皮肤感觉减退,考虑为术中损伤腓浅神经所致.结论 低旋转点外踝上皮瓣切取较

  10. Observações sôbre o bronzeado do algodoeiro Mocó Observations on bronzing of the Mocó cotton

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    A. S. Costa

    1955-01-01

    Full Text Available Uma anomalia do algodoeiro Mocó, denominada bronzeado, vem sendo observada na região do Seridó, Rio Grande do Norte, durante os últimos três anos. Pensou-se, a princípio, que esta anomalia fôsse causada por um vírus, mas as observações relatadas neste trabalho indicam que é causada por um ácaro. As fôlhas das plantas afetadas, especialmente aquelas da metade superior dos galhos, mostram uma coloração bronzeada no lado de baixo. Essa face da fôlha tem também uma superfície rugosa, com brilho vidrado (est. 1, B, as vezes com pequenas áreas de tecido cicatricial. Vistas pelo lado de cima são mais rugosas do que as normais e têm os bordos curvados para baixo. Nos casos graves, as fôlhas do topo dos galhos morrem e caem (est. 2, A e B. A espécie de ácaro causadora do bronzeado do algodoeiro Mocó foi identificada por H. H. Keifer, Sacramento, Calif., como pertencente a um gênero ainda não descrito da família Eriophyidae. Esta espécie está sendo presentemente denominada Anthocoptes sp. até que a sua descrição seja publicada. Populações de 500 a 1.000 indivíduos por centímetro quadrado de fôlha já foram encontradas. Esse ácaro parece ser muito sensível às condições do ambiente, visto que as populações da praga variam entre grandes limites.For the last three years a bronzing anomaly of cotton plants of the Mocó variety (Gossypium hirsutum L. var. maria galante Hutch. has been recorded in the Seridó region (a semi-arid region in the north-eastern part of Brazil, state of Rio Grande do Norte. This anomaly was first thought to be of virus origin, but the observations reported in this paper indicated that it is due to the attack by a species of mite. Leaves from affected plants, especially those on the upper half of the branches, show a bronzing discoloration on the dorsal side, frequently accompanied by a rough and ventral side of these leaves shows some rugosity not present in normal leaves, and in most cases

  11. Uretrostomia peniana e perineal em felinos domésticos Penile and perineal urethrostomy in domestic cats

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    Erika Cosendey Toledo de Mello Peixoto

    1997-12-01

    Full Text Available O conteúdo do presente trabalho é o resultado de diferentes técnicas de uretrostomia em felinos domésticos. Foram utilizados vinte quatro gatos sem raça definida, machos, distribuídos em quatro grupos de seis animais cada e submetidos a orquiectomia e aos seguintes procedimentos cirúrgicos: uretrostomia peniana cranial (grupo I, uretrostomia peniana caudal (grupoII, uretrostomia peniana craniocaudal (grupo III e uretrostomia perineal associada à penectomia cranial (grupo IV. Os resultados foram avaliados através de exame clínico geral, realizado do primeiro dia ao nonagésimo dia após intervenção cirúrgica. O aspecto macroscópico da ferida cirúrgica, grau de contração e aspecto estético foram inspecionados diariamente até a retirada dos pontos externos. Foram realizados exame de urina tipo l e urocultura, apenas nos animais que apresentaram melhores resultados: aqueles submetidos à uretrostomia peniana craniocaudal e à uretrostomia perineal associada à penectomia cranial. Esses exames foram realizados 24h antes do procedimento cirúrgico (T0, 15 (Tl e 30 (T2 do período pós-operatório. Os animais do primeiro grupo apresentaram fechamento completo da uretra peniana, os do segundo grupo apresentaram intensa retração cicatricial pós-operatória que promoveu exposição peniana permanente. Os animais do grupo III, também desenvolveram exposição peniana permanente, porém em menor grau. Os resultados apresentados por todos os indivíduos do grupo IV foramos melhores, sendo a técnica recomendada para desobstrução uretral em gatos.The content of lhe present paper is lhe result of different technics for urethrostomy in domestic cats. Twenty four mongrel males cats were used. They were distributed in four groups of six animais each and the following protocol were used: cranial penile urethrostomy (group 1, caudal penile urethrostomy (group II, association of the previous techniques (group III and association of cranial

  12. Effect of topical application of fibronectin in duodenal wound healing in rats Efeito da aplicação tópica da fibronectina em feridas duodenais de ratos

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    Teresa Neuma de Souza Brito

    2003-03-01

    de solução 0,9% e no grupo teste (n=15 a lesão duodenal foi tratada com FN 1%. A cicatrização da lesão foi estudada após cinco, sete e dez dias de observação. O estudo histopatológico foi realizado nas colorações hematoxilina-eosina, tricrômico de Masson e reação imunohistoquímica para FN. Um sistema digital de graduação histológica foi usado para obtenção de escores para cada grupo. RESULTADOS: A FN esteve expressada em todas as camadas estudadas do duodeno. Os níveis celular e plasmático da FN aumentaram linearmente com a evolução do processo cicatricial. No grupo teste a FN contribuiu para melhorar a cicatrização das lesões nos três intervalos do estudo, quando se fez a comparação com o grupo de controle. CONCLUSÃO: O uso tópico de FN em feridas duodenais suturadas de ratos melhora a cicatrização mediante o incremento no aparecimento de fibroblastos, colágeno e tecido de granulação. Esta aceleração na cicatrização pode significar um importante papel na consolidação dessas lesões.

  13. Antibióticos em tonsilectomias: terapêutico ou profilático? Necessário ou abusivo? Antibiotic use in tonsillectomies: therapeutic or prophylactic? Required or excessive?

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    Otávio Bejzman Piltcher

    2005-10-01

    Full Text Available A adenotonsilectomia é uma das cirurgias mais comumente realizadas na população pediátrica e adulta jovem. A morbidade pós-operatória de tal procedimento cirúrgico é importante incluindo odinofagia, disfagia, otalgia, febre, halitose, perda ponderal e redução da aceitação por via oral. Após a tonsilectomia, com ou sem adenoidectomia, a colonização da loja tonsilar aberta pela flora bacteriana oral causaria uma exacerbação da reação inflamatória local, piorando a dor pós-operatória. A hipótese de que a redução da população bacteriana na ferida cirúrgica aberta possa diminuir a inflamação local, promover o processo cicatricial e acelerar a recuperação pós-operatória determinou inúmeros estudos que abordaram a relação entre o uso perioperatório de antibióticos e a morbidade pós-operatória da adenotonsilectomia. Apesar desses estudos se definirem como avaliadores do uso profilático cirúrgico de antibióticos nessas cirurgias, não houve seguimento das normas de antibioticoprofilaxia cirúrgica internacionalmente aceitas, sendo que a maioria utiliza antibióticos por sete dias pós-operatórios. Através de uma revisão crítica da literatura, os autores discutem os prós e contras do uso de antibiótico nas tonsilectomias ou adenotonsilectomias, assim como a correta definição para sua utilização.Adenotonsillectomy is one of the most commonly performed surgeries in the pediatric and young adult populations. The postoperative morbidity of this surgical procedure is often significant, including odynophagia, dysphagia, fever, halitosis, loss of weight and reduced oral intake. After tonsillectomy, with or without adenoidectomy, the colonization of the open tonsillar fossae by the bacterial population of the oral cavity would cause an exacerbation of the local inflammatory response worsening postoperative pain. The hypothesis that a reduction of the bacterial population of an open surgical wound could

  14. 都江堰友爱学校地震伤员康复状况调查分析%Rehabilitation needs of earthquake victims in Dujiangyan Youai primary school in Sichuan Province

    Institute of Scientific and Technical Information of China (English)

    潘福琼; 黎浩然; 杨玉龙; 田金艳; 赵冠兰; 彭博; 陈启明; 罗尚蔚; 何锦华; 彭元宏

    2011-01-01

    Objective To investigate the status of dysfunction and rehabilitation needs of earthquake victims in Dujiangyan Youai primary school in Sichuan Province,to provide a guideline for further rehabilitation. Methods Live investigation was performed for 105 patients in the school. Amputation Body Image Scale (ABIS)was used as psychological assessment to investigate the psychological status of 40 amputees. Results Among the 105 victims,there were 44 cases of fracture (41.9%) ,40 cases of amputee ( 39% ),15 cases of crush syndrome ( 14. 2% ) and 6 cases of head injury (5. 7% ). Most of them had different levels of physical dysfunction,including 62 cases of decreased muscle strength ( 59. 1% ) ,32 cases of muscular atrophy ( 30. 2% ) ,49 cases of limited range of motion ( ROM ) ( 46. 7% ) , 70 cases of cicatricial adhesion ( 66. 7% ) , 14 cases of sensory disorder ( 13.3% ) , 32 cases of arthrogryposis ( 30. 5% ) ,23 cases of abnormal gait ( 21.9% ) and 26 cases of limitation in activities of daily living ( ADL ) ( 24. 8% ). Conclusions Sichuan earthquake victims in Youai primary school had different levels of rehabilitation needs. Further rehabilitation is needed and intensive attention should be paid to those wounded with psychological problems.%目的 分析全国首家无障碍学校--四川省都江堰友爱学校地震伤员的伤情、功能障碍、康复现状及需求,为下一步康复医疗提供依据.方法 对105例在校伤员进行现场功能评估,采用截肢身体意象评估量表(ABIS),对40名截肢伤员进行问卷调查.结果 105例伤员中,骨折44例(41.9%)、截肢40例(39%)、挤压伤15例(14.2%)、脑外伤6例(5.7%);大都存在的不同程度、多种功能障碍问题,其中肌力减退62例(59.1%),肌肉萎缩32例(30.2%),关节活动度(ROM)受限49例(46.7%),瘢痕粘连增生70例(66.7%),感觉障碍14例(13.3%),关节挛缩32例(30.5%),步态异常23例(21.9%),生活不能完全自理26例(24.8%).结论 105

  15. Repair of perforating skin and soft tissue defects of the palms with dorsalis pedis parallel flaps%足背并联皮瓣修复手掌贯穿性皮肤软组织缺损

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    冯仕明; 王爱国; 高顺红

    2015-01-01

    Objective To explore the effect of dorsalis pedis parallel flaps in repairing perforating skin and soft tissue defects of the palms.Methods Eighteen patients with perforating skin and soft tissue defects of the palms were hospitalized from July 2008 to November 2010.The area of skin defect ranged from 2.0 cm × 1.5 cm to 5.0 cm ×2.5 cm.The dorsalis pedis parallel flaps were used to repair these defects,with the area ranging from 2.0 cm × 2.0 cm to 5.5 cm × 3.0 cm.The donor sites were covered with autologous full-thickness skin from inner thigh.Results All the 18 flaps and skin grafts of donor sites survived completely.Seventeen patients were followed up for 6 to 23 months,with mean time of 10 months,and one patient was lost to follow-up.The texture,elasticity,and appearance of all the 17 flaps were satisfactory,with no obvious pigmentation or cicatricial contracture.At the last follow-up,the distance of two-point discrimination of flaps ranged from 6 to 9 mm,with mean distance of 7.4 mm,and the sensation of flaps reached S3 in 13 patients who had nerve anastomosis.Conclusions The dorsalis pedis parallel flap,with reliable blood supply and flexible design,is a good choice for repairing perforating skin and soft tissue defects of the palms.%目的 探讨采用足背并联皮瓣修复手掌贯穿性皮肤软组织缺损的疗效. 方法 2008年7月-2010年11月,笔者单位收治18例手掌贯穿性皮肤软组织缺损患者.单处皮肤软组织缺损面积为2.0 cm×l.5 cm~5.0 cm ×2.5 cm.应用足背并联皮瓣治疗,单处皮瓣切取面积为2.0 cm×2.0 cm~5.5 cm ×3.0 cm.供瓣区创面采用自体大腿内侧全厚皮片修复. 结果 术后18例患者皮瓣全部成活,所有足部供区植皮均成活.本组17例患者术后随访6~23个月,平均10个月;l例患者失访.17例皮瓣外观恢复较好,皮瓣质地柔软、弹性好,无臃肿,未见明显色素沉着以及瘢痕挛缩.行神经吻合的13例患者,末次随访时皮

  16. Influência do ácido ascórbico em anastomoses e alças jejunais íntegras de rato Influence of ascorbic acid on anastomotic and jejunal resistance in rat

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    Andy PETROIANU

    2001-01-01

    Full Text Available Racional - O efeito do ácido ascórbico sobre os processos cicatriciais anastomóticos apresenta resultados conflitantes na literatura. Objetivo - Comparar a resistência cicatricial de anastomoses e de segmentos íntegros jejunais de ratos submetidos a administração de vitamina C, em distintos períodos pós-operatórios. Método - Foram estudados 50 ratos Wistar, submetidos a secção e subseqüente anastomose término-terminal de segmento jejunal, a 10 cm da flexura duodenojejunal. Os animais foram divididos em dois grupos (n = 25: Grupo I - controle; Grupo II - administração de vitamina C oral, 100 mg/kg. Avaliaram-se as pressões de ruptura anastomótica e do segmento íntegro jejunal nos 3º, 5º, 7º, 21º e 28º dias pós-operatórios. Resultados - Os ratos que receberam vitamina C apresentaram uma pressão de ruptura anastomótica maior nos 5º, 7º e 28º dias pós-operatórios. O mesmo ocorreu com as pressões de ruptura do segmento íntegro jejunal dos ratos. Conclusões - A vitamina C aumentou a resistência das anastomoses jejunais dos ratos, tanto no pós-operatório imediato, quanto no tardio. Além disso, a resistência final dos segmentos jejunais íntegros dos ratos submetidos a administração de vitamina C foi significativamente maior do que no Grupo Controle.Backgroud - The effects of vitamin C on anastomotic healing process are controversial. Objective - To compare the jejunal anastomotic tension and in the upright segment in different postoperative periods. Method - Fifty male rats weighing 250 to 400 grams were submitted to laparotomy. The jejunum was transversally cut 10 cm from the duodenojejunal flexure, and subsequently anastomosed. The rats were divided into two groups (n = 25. Group I - control, Group II - oral administration of vitamin C (100 mg/kg. The anastomotic and the upright segment resistance was determined by using bursting pressure test on the 3rd, 5th , 7th , 21st and 28th postoperative days

  17. Efeito da mitomicina C tópica na cicatrização de prega vocal em modelo suíno Topical mitomycin C effect on swine vocal folds healing

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    Paulo Antônio Monteiro Camargo

    2006-10-01

    Full Text Available Várias terapias adjuvantes à cirurgia vêm sendo usadas para modular o processo cicatricial nas pregas vocais, entre elas a Mitomicina tópica (MTC. OBJETIVOS: Avaliar os efeitos da MTC no processo de cicatrização de pregas vocais de suínos 30 dias após exérese de fragmento de mucosa com laser de CO2 mediante a mensuração da deposição de colágeno. FORMA DE ESTUDO: Experimental em suínos. MATERIAIS E MÉTODOS: Dois grupos de 6 suínos cada foram avaliados após exérese de fragmento de mucosa de prega vocal a laser de CO2 (grupo controle sem uso e grupo experimento com uso de MTC tópica. Após 30 dias os animais foram submetidos à eutanásia, sendo coletadas amostras das pregas vocais para análise histológica, a fim de quantificar a deposição de colágeno mediante coloração de Picrosirius Red. RESULTADOS: A média da área do colágeno total das pregas vocais do grupo controle foi de 2648,03 µm2, enquanto a média do colágeno total das pregas vocais do grupo experimento foi de 2200,30 µm2 (p = 0,0043. CONCLUSÃO: A MTC usada topicamente após a exérese de fragmento de mucosa da prega vocal a laser de CO2 em suínos, diminui, significativamente, a deposição do colágeno total.several adjuvant therapies to surgery have been used to modulate the healing process of vocal folds, including topic mitomycin (MTC. AIM: to evaluate the effect of topical MTC in the healing process of vocal folds 30 days after the exeresis of a mucosal fragment with CO2 laser in a swine model (control group without mitomycin and study group with topical MTC, with collagen deposition measurement. STUDY TYPE: prospective experimental in swine. METHODS: two groups of 6 swine each were subjected to exeresis of a mucosal fragment of the vocal fold with CO2 laser. Immediately after the procedure MTC was applied topically for three minutes on the study group. Thirty days later the animals were slaughtered and samples of the vocal folds were collected for

  18. Profile of wound healing process induced by allantoin Perfil do processo de cicatrização induzido pela alantoína

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    Lorena Ulhôa Araújo

    2010-10-01

    Full Text Available PURPOSE: To evaluate and characterize the wound healing process profile induced by allantoin incorporated in soft lotion oil/water emulsion using the planimetric and histological methods. METHODS: Female Wistar rats (n=60 were randomly assigned to 3 experimental groups: (C control group-without treatment; (E group treated with soft lotion O/W emulsion excipients; (EA group treated with soft lotion O/W emulsion containing allantoin 5%. The emulsions either containing or not allantoin were topically administered for 14 days and the wound area was evaluated by planimetry and by qualitative and quantitative histological analysis of open wound model. RESULTS: The data which were obtained and analyzed innovate by demonstrating, qualitatively and quantitatively, by histological analysis, the profile of healing process induced by allantoin. The results suggest that the wound healing mechanism induced by allantoin occurs via the regulation of inflammatory response and stimulus to fibroblastic proliferation and extracellular matrix synthesis. CONCLUSION: This work show, for the first time, the histological wound healing profile induced by allantoin in rats and demonstrated that it is able to ameliorate and fasten the reestablishment of the normal skin.OBJETIVO: Avaliar e caracterizar o perfil cicatricial induzido pela alantoína incorporada em uma emulsão óleo/água, sob os aspectos planimétrico e histológico. MÉTODOS: Ratos Wistar fêmeas (n=60 foram agrupados aleatoriamente em três grupos experimentais grupo controle - sem tratamento (C; grupo tratado com emulsão pura (E; grupo tratado com emulsão contendo 5% de alantoína (EA. As emulsões contendo ou não alantoína foram administradas topicamente durante 14 dias e a área da ferida foi avaliada por planimetria e por análise histológica qualitativa e quantitativa em modelo de ferida aberta. RESULTADOS: Na análise planimétrica não foi observado diferenças significativas entre os grupos

  19. Intraoperative topical administration of mitomycin C, in different concentrations, on the cicatrization of mioplasties of the dorsal rectus of rabbits Administração tópica per-operatória da mitomicina C, em diferentes concentrações, sobre a cicatrização de mioplastias do reto dorsal de coelhos

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    Fabrício Villela Mamede

    2008-02-01

    Full Text Available Myoplasties of the extraocular muscle may cause adhesions between the operated muscle and the adjacent tissues, commonly generating cicatricial strabismus. With the purpose of reducing to a minimum the occurrence of adhesion, the effects of mitomycin C, an antifibrotic agent, were studied in concentrations of 0.008%, 0.02%, and 0.04% applied during intraoperative of myoplasties of the superior rectus muscle of rabbits. Fifty six animals were divided in five groups. During the postoperative, the operated areas were washed with physiological solution. Eye drop instillation to prevent inflammation and bacterial infection were used. The method to analyze the results consisted of clinical and histological evaluation and statistical analyzes. We also evaluated at the same time the amount of basic fibroblast growth factor (FGF-2 by immunohistochemical study. Clinically, more adhesions were found in the eyes of the control group than in the groups of treated eyes. However there was no significant statistics difference between the two groups (P>0.05. Histologically, mitomycin C caused a delayed cicatrization in the mioplastic areas, specially in the group who received the 0.02% concentration. The immunohistochemical showed FGF-2 marking in fibroblasts and macrophages, but between the groups there wasn't no difference. Based on those results, mitomycin C in the utilized concentrations was capable of delaying the cicatrization and consequently avoid the secondary strabismus without undesirable side effects.Mioplastias da musculatura extra-ocular podem ensejar aderências entre o músculo operado e os tecidos adjacentes, produzindo, não raro, estrabismos cicatriciais. Com intuito de se minimizar a ocorrência de aderências, investigaram-se os efeitos da mitomicina C, como agente antifibrótico, em concentrações ascendentes de 0,008, 0,02 e 0,04%, aplicada no per-operatório de mioplastias do reto superior do bulbo do olho de coelhos. Operaram-se 56

  20. 口腔颌面部结节性筋膜炎临床病理分析%Clinical and Pathological Analysis of Nodular Fasciitis in Oral and Maxillofacial Region

    Institute of Scientific and Technical Information of China (English)

    李海如

    2015-01-01

    目的探讨结节性筋膜炎的临床及病理学特征及其鉴别诊断。方法对23例口腔颌面部结节性筋膜炎临床和病理资料进行复习,重新确诊。结果结节性筋膜炎表现为生长迅速,肿块小,质硬边界不清软组织肿块。光镜特点疏松的粘液样基质中有丰富的增生活>肥胖的梭形细胞,核分裂像多见,胆病理性核分裂罕见,低倍镜下呈疏密相间的“区带现象”,可呈席纹状,束状,半旋涡状或“S”形排列,基质内有小裂隙及微囊样形成呈网眼状结构,病灶边缘有新生毛细血管和炎细胞集中,红细胞外渗。结论结节性筋膜炎诊断应紧密结合其临床病史中生长快的特点,显微镜下注意观察5个组织学特征,因病理形态呈多态性,故易误诊为恶性软组织肉瘤。%Objective To explore the clinical and pathological features of nodular fasci tis and its dif erential diagnosis.Methods To review the 23 cases of oral and maxil ofacial nodular fasci tis:clinical and pathological data,re diagnosed.Results Nodular fasci tis showed rapid growth,mass of smal ,hard boundary is not clear soft tissue mass.A spindle cel rich hyperplastic obesity myxoid matrix light characteristics of osteoporosis,mitosis was common,bilious rational rare mitotic figures,at low magnification is spacing"zone phenomenon",can be in a storiform,fasciculate,semi spiral or"S"shaped ar angement,mucus like matrix loose feathery structure or tissue culture like growth,longer course,cicatricial col agen formation,stroma with smal cracks and microcystic form a mesh like structure,lesion edge newborn capil aries and inflammatory cel concentration,erythrocyte extravasation.Conclusion The diagnosis of nodular fasci tis should be closely combined with the characteristic of the clinical history in fast growth,pay at ention to characteristics of 5 tissue under the microscope observation,due to pathological morphology are polymorphic

  1. Tuberculose laríngea: proposta de intervenção fonoaudiológica nas sequelas de voz após o tratamento farmacológico Laryngeal tuberculosis: proposal of Speech-Language Pathology intervention in voice disorders following pharmacological treatment

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    Raquel de Cássia Ferro Fagundes

    2011-03-01

    Full Text Available A tuberculose é uma doença que esteve presente durante toda história. No século XIX o bacilo causador da doença foi descoberto e denominado bacilo de Koch. A tuberculose laríngea é uma das complicações da tuberculose pulmonar, e o sintoma mais comum é a rouquidão, decorrente ao processo cicatricial das lesões laríngeas. Sendo assim, o objetivo deste estudo foi verificar a efetividade da fonoterapia em um caso de disfonia pós-tratamento medicamentoso da tuberculose laríngea. A metodologia utilizada foi o estudo de caso do paciente J.O.B.S, 39 anos, gênero masculino, recepcionista de hotel, com jornada de oito diárias e ex-fumante, que trouxe como queixas principais rouquidão, cansaço e falta de ar durante a fala. Após as avaliações fonoaudiológica e otorrinolaringológica iniciaram-se as sessões de fonoterapia, com objetivo de diminuir a tensão à fonação, induzir o afastamento de pregas vestibulares, favorecer a mobilidade das pregas vocais, instaurar a respiração com apoio abdominal e melhorar a coordenação pneumofonoarticulatória. Após as 12 sessões previstas na metodologia desse estudo, diversos parâmetros vocais apresentaram melhoras, dentre eles a diminuição da tensão à fonação, respiração com apoio abdominal, melhoria da coordenação pneumofonoarticulatória, aumento da loudness e diminuição do ataque vocal brusco, que refletiram em uma emissão com menor esforço e mais aceita socialmente. A terapia fonoaudiológica, apesar das limitações decorrentes aos processos cicatriciais das lesões, mostrou-se importante no caso apresentado e o paciente ficou satisfeito com os resultados obtidos, os quais refletiram de forma positiva na comunicação oral e no convívio social do paciente.Tuberculosis is a disease that has been present throughout history. In the XIX century the agent that causes the disease was discovered and named mycobacterium tuberculosis. Laryngeal tuberculosis is one of the

  2. Viabilidade do baço de ratos após a ligadura dos vasos esplênicos: efeito do tratamento com oxigênio hiperbárico Viability of the spleen in rats after ligation of the splenic vessels: effects of hyperbaric oxygen therapy

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    Danilo Nagib Salomão Paulo

    2005-02-01

    Full Text Available OBJETIVO: Verificar o efeito da ligadura dos vasos esplênicos principais no baço de ratos e a influência do tratamento com o oxigênio hiperbárico após a ligadura. MÉTODOS: Foram operados 69 ratos Wistar, machos, de 285g a 375 g. Os animais foram divididos aleatoriamente em três grupos: grupo 1: quatro ratos, simulação; grupo 2: 34 ratos, ligadura simultânea da artéria e veia esplênica; grupo 3: 31 ratos, ligadura da artéria e veia esplênica seguida de oxigenioterapia hiperbárica no pós-operatório por 11 dias, sendo mortos no 12º dia. O baço era retirado e incluído em parafina para estudo microscópico. RESULTADOS: O baço era normal em 8,82% e 45,16%, respectivamente, no grupo que sofreu a ligadura vascular sem ou com oxigenioterapia hiperbárica (p= 0,01. O percentual de massa viável do tecido esplênico nos baços que infartaram em relação ao percentual da massa corporal dos animais não diferiu entre os grupos 2 e 3. O aspecto histopatológico mostrou arquitetura preservada na porção não infartada nos dois grupos e neoformação conjuntivo-vascular cicatricial mais acentuada no grupo que recebeu oxigênio hiperbárico. CONCLUSÕES: O tratamento com oxigênio hiperbárico, a partir do pós-operatório imediato, após a ligadura simultânea da artéria e da veia esplênicas, reduziu significativamente a freqüência dos infartos, mas não alterou o percentual de massa viável dos baços, quando o infarto ocorreu, e acelerou o processo de cicatrização, com aumento da proliferação de fibroblastos e da neoformação vascular.OBJECTIVE: To investigate the effects of splenic artery and vein ligation and the influence of hyperbaric oxygen after the double vascular ligation on the viability of spleen tissue. Methods: Sixty nine adult male Wistar rats (285-375g were randomly separated in three groups: group 1, four rats, sham operated, group 2, 34 rats, submitted to simultaneous splenic artery and vein ligation and group

  3. Complicações e condutas fisioterapêuticas após cirurgia por câncer de mama: estudo retrospectivo Complications and physical therapeutic treatment after breast cancer surgery: a retrospective study

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    Simony Lira do Nascimento

    2012-09-01

    Full Text Available Após cirurgia por câncer de mama, as mulheres estão sujeitas a desenvolver algumas complicações físicas. Os objetivos deste trabalho foram: investigar o desfecho dessas mulheres, que, durante o primeiro mês pós-operatório, foram submetidas a um programa de reabilitação e identificar ao longo de dois anos as complicações mais frequentes e as condutas fisioterapêuticas mais adotadas. Foi um estudo descritivo, retrospectivo, com dados de 707 prontuários de mulheres operadas por câncer de mama no Hospital da Mulher Professor Doutor José Aristodemo Pinotti da Universidade Estadual de Campinas, entre janeiro de 2006 e dezembro de 2007, atendidas pelo Setor de Fisioterapia. A análise foi feita por meio de médias, desvio padrão e frequências absolutas e relativas. Ao final do programa, 55% das mulheres receberam alta, 17% necessitaram de atendimento adicional e 26% não aderiram a ele. As complicações mais frequentes foram: aderência pericicatricial (26%, restrição da amplitude de movimento (24% e deiscência cicatricial (17%. No primeiro ano após a cirurgia (n=460, foram relatados dor (28,5%, sensação de peso (21,5% e restrição da amplitude de movimento do ombro (16,7%; já no segundo (n=168, houve dor (48,2%, sensação de peso (42,8% e linfedema (23,2%. Concluiu-se que, ao final do programa, a maioria das mulheres recebeu alta. Ao longo dos anos, houve redução da frequência de restrição da amplitude de movimento do ombro com aumento de linfedema. Cuidados com o braço, exercícios domiciliares e autodrenagem foram as condutas mais adotadas.After breast cancer surgery, women may develop some physical complications. Thus, the aims of this study were to investigate the outcome of these women, who participated in a rehabilitation program for one month, as well to identify along two years the most frequent complications and adopted physical therapy conducts. It was a descriptive and retrospective study with 707 medical

  4. Estudo experimental comparando o uso do 2-octil cianoAcrilato ao nylon 4-0 na sutura da pele Experimental study comparing 2-octyl cyanoacrylate to nylon for skin closure

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    Ruffo de Freitas-Júnior

    2008-06-01

    Full Text Available OBJETIVO: Comparar o 2-octil cianoacrilato com o fio de "nylon" no fechamento da pele em ratos. MÉTODOS: Vinte e cinco ratos da linhagem Wistar, foram submetidos à incisão de 3 cm de cada lado do abdome. A síntese foi feita utilizando em um dos lados o "nylon" 4.0, pontos intradérmicos, e do outro o 2-octil cianoacrilato. Após sete dias, o fio foi removido e as incisões, analisadas quanto às complicações. Após 40 dias, o resultado da cicatriz foi avaliado. Os ratos foram sacrificados, as cicatrizes foram ressecadas, fixadas e enviadas ao patologista, sem informação sobre qual o método utilizado. RESULTADOS: Houve dois óbitos durante a anestesia e um tardio. O tempo de operação foi de 136 segundos com a cola e 176 segundos, com o "nylon" (P=0,003. Dentre as 50 operações realizadas, as complicações foram: um hematoma com cada método (P=0,80, quinze deiscências da cola contra 11 do "nylon" (P=0,20, sete cicatrizes de aspecto ruim ou razoável da cola contra quatro do "nylon" (P=0,30, três infecções na cola contra duas (P=0,40. Ao exame patológico, a mediana da largura da cicatriz foi de 1.119 micra com a cola e 1.800 com o "nylon" (P=0,40. A espessura foi de 1.795 contra 1.705 micra (P=0,40. CONCLUSÃO: O 2-octil cianoacrilato apresentou o mesmo aspecto cicatricial, a mesma resistência e as mesmas complicações que a sutura com o "nylon" 4.0, porém permitindo redução no tempo cirúrgico.BACKGROUND: Tissue adhesive 2-octyl cyanoacrylate was developed to have more strength, less inflammatory reaction, and less histotoxicity than its shorter-chain derivates. METHODS: To evaluate the use of 2-octil cyanoacrylate in comparison with "nylon" suture in skin closure of rats. Methods: Twenty-five female Wistar rats were submitted to a 3cm surgical incision in each side of the abdomen. The wound was closed with intradermic suture using "nylon" 4-0 in one side, and 2-octil cyanoacrylate on the other side. After 7 days the thread

  5. Efectos de la desnutrición sobre la colagenización de anastomosis intestinales: análisis de procolágeno y telopéptido carboxiterminal mediante radioinmunoanálisis Role of malnutrition in intestinal anastomosis collagenization: an analysis of procollagen (PINP and carboxyterminal telopeptide (ICTP by radioimmunoassay

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    J. M. Álamo

    2007-02-01

    Full Text Available Introducción: diversos factores influyen en la cicatrización correcta de las suturas intestinales tras la práctica de una resección intestinal. Uno de los factores más implicados es el estado nutricional del paciente. Objetivos: evaluar la influencia de la desnutrición inducida sobre la viabilidad de una anastomosis intestinal primaria mediante el análisis del procolágeno (PINP como marcador de la síntesis de colágeno I, y del telopéptido carboxiterminal del colágeno I (ICTP como marcador de la destrucción del mismo. Métodos: 40 ratas Wistar y material de radioinmunoensayo. Métodos: diseñamos 2 grupos de ratas, 20 animales por cada grupo: grupo control (A y grupo "desnutrición" (B. Se analiza PINP e ICTP mediante RIA sobre tejido colónico homogeneizado, preanastomótico y anastomótico. Resultados: existen unos niveles menores de PINP en el colon de las ratas del grupo B comparado con el colon del grupo A (0,3620 y 0,4340 µg/g respectivamente (p = 0,032. Hay un mayor nivel de ICTP analizado en el colon del grupo B (0,9545 en contraposición a 0,8460 µg/g en el grupo A (p = 0,875. En las anastomosis del grupo B existe una menor síntesis de PINP en comparación con el grupo A (0,376 y 0,468 µg/g respectivamente, p = 0,002. Conclusiones: la anastomosis colónica incrementa los niveles de PINP e ICTP en el tejido cicatricial (p = 0,000; la malnutrición reduce la colagenización de las anastomosis (p = 0,000.Introduction: some clinical, anatomo-pathological, and technical factors influence the correct healing of intestinal suture following an intestinal resection. One of the most influential factors is patient nutritional status. Objectives: to evaluate the influence of malnutrition on the viability of primary intestinal anastomosis by the analysis of collagen I deposition. Methods: 40 Wistar rats, radioimmunoassay material. We used 2 groups of rats, 20 animals in each group: a control group (A and a "malnutrition" group (B

  6. Effect of thalidomide on the healing of colonic anastomosis, in rats Efeito da talidomida na cicatrização de anastomoses colônicas em ratos

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    Samuel Gama Veneziano

    2008-01-01

    ção de talidomida 1,0 mg/kg por 7 dias. Foi realizada anastomose término-terminal contínua de prolene 6-0. O sacrifício foi no 7º. dia pós operatório e as anastomoses foram analisadas quanto a aspecto macroscópico, dosagem de hidroxiprolina, histologia em hematoxilina-eosina e imuno-histoquímica para metaloproteinase 1, inibidor de metaloproteinase 1 e VEGF. RESULTADOS: Não houve diferença estatisticamente significante para a observação macroscópica e para dosagem de hidroxiprolina (p=0,5403. Na análise imunohistoquímica, para VEGF houve p=0,5817, para metaloproteinase 1, p=0,1854 e para inibidor de metaloproteinase, p=0,0023, considerado estatisticamente significante. CONCLUSÃO: Concluímos que a talidomida influenciou na maturação do colágeno. Notou-se maior ação das metaloproteinases, que pode significar uma tendência negativa para o processo cicatricial.

  7. Avaliação histomorfométrica do efeito do extrato aquoso de urucum (norbixina no processo de cicatrização de feridas cutâneas em ratos

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    J.A.A. Santos

    2014-01-01

    Full Text Available A norbixina é um carotenóide dicarboxílico hidrofílico presente no pericarpo das sementes do urucuzeiro (Bixa orellana L.. O urucum é comumente utilizado na indústria alimentícia e cosmética como corante natural. O objetivo deste trabalho foi avaliar o processo de reparo cicatricial de feridas cutâneas abertas de ratos tratadas com extrato aquoso de urucum contendo 2,5% de norbixina através de análise histomorfométrica. Para tanto, realizou-se feridas cutâneas no dorso de 32 ratos Wistar machos. Estas foram tratadas com extrato de urucum (grupo experimental, n = 16 e solução salina 0,9% (grupo controle, n = 16. Aos 3, 7, 14 e 21 dias após realização do procedimento cirúrgico, os animais foram sacrificados. Os preparados histológicos obtidos foram submetidos à técnica de coloração pela Hematoxilina-Eosina (H.E. para contagem de células inflamatórias e de fibroblastos; corados pelo azul de toluidina 1% para contagem dos mastócitos e com picrossirius-red para avaliação das fibras colágenas totais. As imagens histológicas destas lâminas foram capturadas por câmera digital acoplada ao microscópio óptico, sob foco fixo e clareza de campo, obtendo-se 10 campos por lâmina com aumento final de 400X. As fotomicrografias foram avaliadas através do software ImageJ. Os resultados obtidos foram submetidos ao teste t de student sendo o valor de p considerado significativo para p< 0,05. O tratamento tópico com extrato de urucum utilizado aumentou o infiltrado inflamatório durante o 3º, 14º e 21º dia pós-operatório. O grupo tratado apresentou maior densidade vascular quando comparado ao controle a partir do 7º e menor quantidade de fibroblastos até o 14º dia pós-cirúrgico. Conclui-se que o extrato de urucum contendo 2,5% de norbixina não é inócuo aos tecidos cutâneos e possui efeitos pró-inflamatórios e pró-angiogênicos durante o processo de reparo tecidual cutâneo em ratos, interferindo no processo

  8. Hernioplastia diafragmática em cão com pericárdio bovino conservado em solução supersaturada de açúcar Diaphragmatic hernioplasty in dogs with bovine pericardium preserved in supersaturated sugar solution

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    A. Mazzanti

    2003-12-01

    Full Text Available Foram utilizados sete cães adultos, três machos e quatro fêmeas, sem raça definida, com pesos entre 10 e 22kg, para avaliação do processo cicatricial do músculo diafragma, na presença do implante de pericárdio bovino conservado em solução supersaturada de açúcar a 300%. Foi criado um defeito na porção muscular do hemidiafragma esquerdo de dimensões 8,0×5,0cm. Após a toracotomia no oitavo espaço intercostal esquerdo, o implante heterógeno foi fixado com fio poliamida nº 3-0 por meio de sutura simples contínua. Decorrido o período pré-estabelecido de pós-operatório, os animais foram submetidos a exames radiográficos simples e contrastado e a estudos macroscópico e histológico. Na avaliação radiográfica, foi verificada presença das silhuetas diafragmática e cardíaca, sem evidências de vísceras abdominais no interior do tórax. Macroscopicamente, notou-se a formação de tecido conjuntivo fibroso semi-transparente que ocluia o defeito diafragmático. O segmento de pericárdio bovino conservado em solução supersaturada de açúcar a 300%, em temperatura ambiente, é substituído por uma fina camada de tecido conjuntivo fibroso e promove a restauração do defeito no músculo diafragma de cão.Seven adult mongrel dogs, three males and four females, weighting between 10 and 22kg were used to evaluate the diaphragmatic muscle healing process. A defect of 8.0×5.5cm was created at the muscular portion of the left hemidiaphragm, through a thoracotomy at the eighth left intercostal space. A segment of bovine pericardium, preserved in 300% sugar solution, was implanted in the diaphragmatic defect. The heterologous implant was sutured with 3.0 polyamide using simple continuous suture. After the observation period, radiologic analysis and macroscopic and histopathologic evaluations were performed. Upon radiographic examination, there was no evidence of interruption of diaphragmatic outline or increased radiopacity at the

  9. Megaesófago en el perro. Revisión bibliográfica y proposición de una nueva clasificación

    Directory of Open Access Journals (Sweden)

    P. TORRES

    1997-01-01

    Full Text Available El megaesófago puede definirse, desde un punto de vista anatómico, como una dilatación patológica del esófago. Esta dilatación puede ser parcial o total y constituye la patología más frecuentemente encontrada cuando se estudian alteraciones de tránsito esofágico, tanto en humanos como en animales. Clínicamente se caracteriza por un "síndrome de regurgitación" debido a un tránsito insuficiente a nivel del esófago, con alteraciones nutricionales y de crecimiento en los cachorros, presentación frecuente de "neumonía por aspiración". En animales adultos el cuadro clínico más frecuente es adelgazamiento y desnutrición crónica, acompañado también de signos neumónicos. Esta patología reconoce etiologías diversas, pero pueden agruparse según orígenes básicamente en dos grupos : a alteración de tránsito consecutivo a una alteración anatómica de la pared del esófago (estenosis, producida, por ej., por estenosis cicatricial, persistencia de un arco aórtico, tumores, etc. b alteración de tránsito consecutivo a una alteración funcional del sistema neurovegetativo. El presente trabajo, junto con efectuar una revisión bibliográfica del tema en cuestión, propone una nueva clasificación de los diferentes tipos de megaesófago en relación al área afectada y su etiología, lo que a juicio del autor clarifica la comprensión y manejo de la patología.When studying the esophagus in both human beings and animals, the most common pathological finding is a megaesophagus. From a pathological stand point megaesophagus can be defined as an abnormal dilatation which can be partial or total. The clinical characteristic of this disorder is the regurgitation syndrome due to insufficient esophageal transit, accompanied by nutritional and growth deficiencies, in puppies, with weight loss, nutritional deficiences as well as pulmonary complications due to pneumonia by aspiration in adult dogs. This pathology has diverse origins which

  10. Bioquímica da esquistossomose mansônica. VI - alterações do compartimento lisossômlco hepático relacionadas ao tempo de infecção

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    Luiz Erlon Rodrigues

    1987-09-01

    , when dead, produce lesions that are sometimes extensive, initially necrotic, then inflammatory and finally cicatricial. These lesions are always circumscribed and not systematized. Besides penetrating into the tiny non-dichotomic branches of the periductal net, the eggs reach the branches of distribution or even the afferent venulae, occluding some of them. Consequently intravascular granulomas are formed which can lead to an interruption of the portal blood stream at this level and to changes in the intralobular circulation. The decrease of the rate of available oxygen and consequent decrease in the intra and extracellular pH are potent labilisers of membranes of several components of the lysosomal compartment. The exit of acid hydrolases, cationic proteins and neutral hydrolases from these organelles brings about major tissular aggression, represented by the formation and maintenance of the typical inflammatory processes of this parasitism. In this work lysosomal activity related to hepatic schisto-somiasis mansoni has been studied. The results indicated that the functional integrity of the lysosomal membrane complexe had been significantly changed. These changes have been observed from the second month of infection and there seems to be a close relationship between the severity of the liver inflammatory lesions and a greater lysosomal lability.

  11. Intradurallysis and peripheral nerve implantation for obsolete incomplete rupture of spinal cord%硬脊膜内松解自体周围神经植入治疗脊髓陈旧性不完全性断裂伤

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    郑旭东; 张少成; 梁俊刚; 黄进; 杨恺

    2009-01-01

    motion increased by at least one grade. The strength of main muscle was increased by 2 grades and reached 4 grades and the walking capability was recovered in six patients. [ Conclusion]The initial good clinical results were obtained for patients with traumatic obsolete incomplete paralysis by relieving the adhesion in the endorhachis,carving the cicatricial spinal cord and implanting the autogenous peripheral nerve.

  12. Estudo morfométrico do músculo sóleo de ratos da linhagem wistar pós–imobilização articular = Morphometric study of post-joint immobilization of soleus muscle on wistar lineage rats

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    Sônia Maria Marques Gomes Bertolini

    2010-01-01

    Full Text Available Todos os tipos de imobilização contribuem para a atrofia muscular e, em apenas alguns dias, os músculos passam por diminuição de volume ou perda de função, conhecidos como atrofia. Assim, com uma ou duas semanas de imobilização, as atividades metabólicas são consideravelmente reduzidas e suas fibras musculares substituídas por tecido cicatricial fibroso denso. Dessa forma, este estudo teve como objetivo analisar o efeito da imobilização articular do músculo sóleo do membro posterior de ratos no perfil morfométrico, em diferentes períodos. Foram utilizados dez Rattus navergicus albinus machos, variedade Wistar, que foram divididos em dois grupos com cinco animais cada, sendo o primeiro grupo submetido à imobilização por sete dias e o segundo por 14 dias. O controle do experimento foi obtido a partir do membro contralateral direito do respectivo animal. A imobilização do membro posterior esquerdo foi por meio de uma órtese adaptada. A análise morfométrica do sóleo foi realizada por meio de cortes transversais não seriados de 5 μm de espessura. Foram analisadas, por meio das imagens obtidas, a área das fibras musculares, juntamente com a densidade do tecido conjuntivo, comparando-as ao Grupo-controle, referentes à perna contralateral. Com sete e 14 dias de imobilização, pode-se observar redução significativa (p All types of immobilization contribute to muscular atrophy and, in a few days, the muscles undergo volume reduction or loss of function, known as atrophy. Thus, with one or two weeks of immobilization, metabolic activities are considerably reduced and muscle fibers are replaced by dense fibrous scar tissue. This study has as objective to analyze the effect of joint immobilization of the soleus muscle of posterior members of rats on morphometric profile view, at periods of 7 and 14 days. Ten male Rattus navergicus albinus, Wistar variety, were used, separated into two groups of 5 animals each, with the first

  13. Ação da l-arginina na evolução de retalhos cutâneos de ratos sob exposição à nicotina L-arginine action in cutaneous flap evolution under nicotine exposure in rats

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    Marcus Vinicius Thomé Nora Guimarães

    2013-02-01

    Full Text Available OBJETIVO: Avaliar se o tratamento com L-arginina influencia a cicatrização de retalhos cutâneos em ratos expostos à nicotina. MÉTODOS: Foram utilizados 40 ratos Wistar pesando 142,4±10,1g separados em quatro grupos: GC- tratamento com solução tampão fosfatos pH 7,4, confecção de retalho cutâneo, observação por 10 dias; GN- exposição à nicotina por quatro semanas, confecção de retalho cutâneo, observação por dez dias; GA- tratamento com solução tampão fosfatos pH 7,4 por quatro semanas, confecção de retalho cutâneo, tratamento com arginina por dez dias; GAN- exposição à nicotina por quatro semanas, confecção de retalho cutâneo, tratamento com arginina por dez dias. Foram avaliadas as áreas de necrose, re-epitelização, reação inflamatória e formação de tecido de granulação, pela coloração HE, a área de deposição total e a diferenciação de colágenos I e III por histometria com a coloração de picrosirius, e, através da marcação imunoistoquímica com anticorpo monoclonal anti-CD34, a densidade vascular cicatricial. RESULTADOS: As porcentagens de áreas de necrose de GN e GNA foram maiores (p0,05 e maiores (pOBJECTIVE: To evaluate whether treatment with L-arginine influences the healing of skin flaps in rats exposed to nicotine. METHODS: 40 male Wistar rats weighing 142.4 ± 10.1 g were separated into four groups: GC: treatment with 7.4 pH phosphate buffer, submitted to skin flap and observation for ten days; GN: exposure to nicotine for four weeks, submitted to skin flap and observation for ten days; GA: treatment with 7.4 pH phosphate buffer for four weeks, submitted to skin flap and arginine treatment for ten days; GAN: exposure to nicotine for four weeks, submitted to skin flap and treatment with arginine for ten days. We evaluated: areas of necrosis, re-epithelialization, inflammatory reaction and formation of granulation tissue by HE stain; the total area of deposition and differentiation

  14. Alterações inflamatórias provocadas pelo metronidazol em feridas: estudo experimental em ratos Inflammatory alterations provoked by metronidazole in wounds: an experimental study in rats

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    Cláudia Paraguaçu Pupo Sampaio

    2009-09-01

    Full Text Available CONTEXTO: Cerca de 2,7% da população brasileira tem úlceras crônicas nos pés e nas pernas, porcentagem que chega a 10% nos diabéticos e que representa a segunda causa de afastamento do trabalho no Brasil. Isso demonstra a necessidade de se encontrar um produto de baixo custo que favoreça a cicatrização dessas feridas. OBJETIVO: Avaliar os efeitos do metronidazol na cicatrização de feridas por segunda intenção. MÉTODOS: Utilizaram-se 80 ratos machos, em cujos dorsos se produziu uma ferida, distribuindo-se, os animais, em dois grupos de 40. Os ratos do grupo-controle tiveram suas feridas tratadas com solução de NaCl 0,9%, e os pertencentes ao grupo-experimento, com metronidazol 4%. No terceiro, sétimo, 14º e 21º dias, avaliou-se o processo cicatricial por parâmetros macroscópicos, histológicos e imunoistoquímicos. RESULTADOS: A concentração de colágeno foi maior nas cicatrizes dos animais do grupo-experimento em todos os tempos examinados. A concentração de colágeno do tipo I também foi significante no sétimo dia (p = 0,020 e no 21º dia (p = 0,016. O colágeno tipo III mostrou concentração semelhante nos tempos iniciais e apresentou-se com maior concentração no 21º dia (p = 0,005. A angiogênese, avaliada pelo anti-CD34, demonstrou maior número de vasos, no grupo-experimento, com diferença significante no terceiro dia (p CONTEXT: Chronic feet and leg ulcers affect about 2.7% of the Brazilian population, 10% of diabetic patients. The condition represents the second most frequent cause of absence from work in Brazil. This shows the need for a product that promotes healing of these wounds at a low cost. OBJECTIVE: To evaluate the effects of metronidazole on ulcer healing by second intention. METHODS: Eighty male rats divided into two groups of 40 had a wound made on their dorsum. The control group was treated with a 0.9% NaCl solution and the experimental group was treated with 4% metronidazole. On the third

  15. Propuesta de una vía de abordaje y técnica para el tratamiento de los síndromes de atrapamiento nervioso lumbar postcirugía (SANLPC, como alternativa a las técnicas de adhesiolisis o epidurolisis Proposal for a new approach and technique for the treatment of post-surgery lumbar nerve entrapment syndromes, as an alternative to adhesiolysis or epidu-ral lysis techniques

    Directory of Open Access Journals (Sweden)

    R. González-Durán

    2006-08-01

    Full Text Available Objetivo: Describir una vía supracicatricial de abordaje y la técnica para la realización de epidurolisis, adhesiolisis y/o bloqueos repetidos radiculares, en síndromes dolorosos por atrapamiento nervioso cicatricial posterior a cirugías de columna lumbar, como alternativa a la epidurolisis caudal descrita en la literatura. Considerando que puede presentar menos complicaciones y puede presentar mejores resultados. Material y método: Ocho pacientes que presentan dolor posterior a cirugías de columna lumbar, con cuadros clínicos de lumbalgia, lumbociatalgia o ciática, con clínica y estudios de imagen (RNM, TAC, mieloTAC sugerentes de fibrosis epidural, estudios de EMG y PESS que indicaban daño en raíces lumbares igual o más que en raíces sacras. Los pacientes no presentaban patología asociada o contraindicaciones para la realización de la técnica. En todos los casos se utilizo: antibioterapia previa, sedación y monitorización del paciente. Se coloca al paciente en decúbito prono, con apoyo abdominal para reducir la lordosis fisiológica posicional y se localiza el espacio interespinoso inmediatamente superior a la cicatriz, para abordar el espacio epidural. Se localiza el espacio epidural con una aguja RX Coudé Curva 8,75 cm 15 g de Epimed® con el bisel orientado caudalmente, confirmando con escopia de alta resolución, mediante la inyección de 0,5 mL de contraste. Se introduce el catéter Tun-L-Kath Epimed® de 19 g y 84,5 cm y se orienta caudalmente hacia el nivel y el lugar con mayor sintomatología con control radiológico directo, hasta la parada en la progresión del catéter y se inyecta contraste para verificar el obstáculo, con la difusión retrógrada del mismo, producida por la fibrosis cicatricial. Se intenta progresar comprobando que al hacerlo hay reproducción de las sensaciones del dolor del paciente. Se extrae la aguja y se vigila la inmovilidad de la punta del catéter con control radiológico. Se tuneli

  16. Paraneoplastic Scleroderma: Are There Any Clues?

    Science.gov (United States)

    Jedlickova, Hana; Durčanská, Veronika; Vašků, Vladimír

    2016-04-01

    with diffusely tough skin on her extremities and trunk, present for 2 months. Examination revealed cervicitis with a benign endometric polyp, cholecystolithiasis, borderline pulmonary hypertension, and a hormonally inactive suprarenal adenoma. She was given prednisone 40 mg/day and penicillamine with effect. In the 3rd year of therapy she has residual induration of her lower legs and a scleroderma plaque in the lumbar region. She is monitored for her suprarenal adenoma. Two patients had scleroderma at the same time as a malignant tumor; in one patient the localized scleroderma worsened rapidly at the time of the tumor diagnosis, and in one patient a clinically silent adenoma was found. Adrenal tissue can secrete molecules such as serotonine or bFGF involved in fibroplasia (3,6). One patient died of a metastatic disease, two patients after the successful treatment of the tumor, and the patient with suprarenal adenoma experienced softening of the skin and regression of scleroderma. Although paraneoplastic scleroderma is often classified as a pseudoscleroderma, we regard neoplasia as a distinct triggering impulse for scleroderma. Recently, an association between RNA polymerase I/III antibodies in systemic scleroderma and cancer was suggested (8). Such studies may confirm the true link between scleroderma and malignancy. These patients are characterized by older age, sudden onset, diffuse thickening of the skin, and/or generalized morphea with a concurrent neoplastic process. In the case of a successful tumor treatment, skin changes regress. PMID:27149136

  17. Association between acute graft versus host disease and lung injury after allogenic hematopoietic stem cell transplantation%异基因造血干细胞移植后急性移植物抗宿主病与肺损伤的关系

    Institute of Scientific and Technical Information of China (English)

    刘启发; 罗晓丹; 范志平; 宁涓; 徐丹; 孙竞; 张钰; 徐兵; 魏永强

    2009-01-01

    Objective To investigate the characteristics of chest hiigh-resolution computed tomography(HRCT)and pathogenesis of acute graft versus host disease(aGVHD)-induced lung injury after allogenic hematopoietic stem cell transplantation(allo-HSCT).Methods Chest HRCT was performed in 47 patients with aGVHD of grade Ⅱ-Ⅳ after allo-HSCT.Twenty-four of the patients underwent different treatment regimens against aGVHD.Before the treatment peripheral blood samples were collected to detect the serum interferon-γ(IFN-γ)and tumor necrosis factor-α(TNF-α).Transbronchial biopsy was performed in 4 patients that failed to recover completely after treatment.Pulmonary function was examined in the patients who survived more than 6 months in every 3 months.Resuits Twenty of tlle 47 patients showed abnormal images by chest HRCT and 17 of the 20 patients were suspected to be witll aGVHD-induced lung iniury.The HRCT images were characterized by diffused interstitial infiltrate in 5 cases.diflused intemtitial and alveolar infiltrate in 7 cases.and diffused interstitial and segmental lobar alveolar infiltrate in 5 cases.Nine cases had bilateral pleural effusion and hydropericardium,including 4 eases accompanied by myocardial hypertrophy.The levels of serum IFN-γ and TNF-α of the patients with lung injury were(6.9±1.8)μg/L and(400±102)μg/L respectively,both not significantly different from those of the patients without lung injury[(6.3±1.2)μg/L and(428±83)μg/L respectively,P=0.202,0.306].The histopathology of the lung tissue was characterized by disorganization,epithelial cell damage,interstitial fibroplasias,and interstitial T lymphocyte or macrophage infiltrate.The effective rate of treatment for aGVHD-induced lung iniury was positively correlated witll that for aGVHD(r=0.771,P=0.01).Eleven of the 24 patients who survived more than 6 months had abnormal pulmonary function.including 7 out of tlle 9 patients with aGVHD-induced lung injury and 4 out the 15 patients without a

  18. 核因子-κB必需调节蛋白结合区多肽在兔胫骨骨髓炎模型中的抗炎效应研究%The anti-inflammatory role of nuclear factor-kappa B essential modulator binding domain peptide in a rabbit osteomyelitis model

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    黄磊; 许长鹏; 贾俊杰; 候毅龙; 覃承诃; 罗吉伟; 林庆荣; 余斌

    2014-01-01

    /kg body weight).C reactive protein(CRP),erythrocyte sedimentation rate (ESR),leucocyte count,and HE staining of focus tissue were observed l to 6 weeks after intervention.Results At pre-intervention,and 1 to 6 weeks post-intervention,the CRP and ESR levels showed a decreasing trend in all the 3 groups while the leucocyte count showed an increasing trend in the blank and control groups but a decreasing trend in the experimental group.At one week post-intervention,there was a significant difference in CRP between the 3 groups (P < 0.05).At 2 weeks post-intervention,the CRP level in the experimental group was significantly different from that in the blank or control group (P < 0.05).At 1 to 6 weeks post-intervention,there was a significant difference in the leucocyte count between the 3 groups (P < 0.05).At 6 weeks post-intervention,HE staining showed even bony staining,no obvious formation of dead bone,dense fibroplasias in the marrow cavity,and no obvious inflammatory cells in the experimental group.Conclusion NBD peptide can block inflammation in a rabbit model of tibia osteomyelitis.

  19. 资木瓜总苷对佐剂性关节炎大鼠滑膜肥大细胞脱颗粒和类胰蛋白酶表达的影响%Effects of Total Saponins of Chaenomeles speciosa on the Number and Degranulation Ratio of Mast Cells and Expression of Tryptase in Synovium of Rats with Adjuvant Arthritis

    Institute of Scientific and Technical Information of China (English)

    李世刚; 刘朝霞; 张永琦; 陈燕

    2012-01-01

    . Synovial tissues of the right hind ankles were sampled and stained with HE for observing synovial pathology to evaluate the effects of TSCS on AA, then stained with TB for observing the number and degranulalion ratio of synovial mast cells and finally detected by immunohistochemical staining method to investigate the expression of tryptase in synovium. Result; TSCS increased significantly the body weight of AA rats, while decreased obviously the paw volume. TSCSsignificantly inhibited inflammatory cell infiltration, synovial cell hyperplasia, and synovial fibroplasia in synovium of AA rats. TSCS could significantly diminish the numbers of total and degranulated mast cells in AA rats, TSCS decreased the expression of tryptase in synovium. Analyzed by Spearman's bivariate correlation, (he number of mast cells and degranulation ratio of mast cells were positively correlated with the pathological scores. Conclusion; TSCS can improve pathological condition of inflammatory synovium in AA rats by inhibiting the function of synovial mast cells, which may play an important underlying role in the immunoregulation of TSCS on AA.

  20. 砷致小鼠肝纤维化模型的建立%Model establishment of liver fibrosis in oral arsenic solution exposed mice

    Institute of Scientific and Technical Information of China (English)

    吴君; 程明亮; 李玲; 李诚秀; 蒋玲; 张韵; 欧兵

    2009-01-01

    Objective To discuss and compare the model estabhshment of liver fibrosis in oral arsenic solution exposed mice and mice with high-fat feedstuff. Methods A total of 240 mice were divided randomly into 6 groups: control group, sodium arsenite group, sodium arsenate group, high-fat feedstuff group, sodium arsenite group with high-fat feedstuff and sodium arsenate group with high-fat feedstuff with 40 mice esch. Control group and high-fat feedstuff group (drinking tap water), sodium arsenite group and sodium arsenite group with high-fat feedstuff (drinking 300 mg/L iAs3+ water), sodium arsenate group and sodium arsenate group with high-fat feedstuff (drinking 300 mg/L iAs5+ water). The mice were sacrificed after 3, 6, 10 months' arsenic-exposure and examined for liver function. HE dyeing and Masson dyeing were also employed to observe the pathological changes in hepatic tissue in each group. Results After 3 months' modeling, ALT and AST in control group, sodium arsenite group, sodium arsenate group, sodium arsenite group with high-fat feedstuff and sodium arsenate group with high-fat feedstuff were (36.7±5.7 ) U/L and (110±22) U/L, (55.6±4.6) U/L and (249±41) U/L, (52.6±8.8) U/L and (161±15) U/L, (311.3±19.7)U/L and (484±15)U/L and (515.0±60.8)U/L and (671±24)U/L. They were higher in all the arsenic groups than in control group (P<0.05); all the HE dyeing samples in arsenic groups showed liver injury in varying degrees such as hydropic degeneration, fatty degeneration, spotty necrosis, fecal necrosis and inflammatory cell infiltration. There were liver cell regeneration and fibroplasias in varying degrees. The liver injury of the mice in all arsenic groups aggravated as exposure time prolonged. Masson dyeing after 10 months' modeling showed hyperplasia in portal areas and central venous areas; the mean area of fibrosis in control group, sodium arsenite group, sodium arsenate group, sodium arsenite group with high-fat feedstuff and sodium arsenate group with

  1. 重组人血管内皮抑制素注射液对激光诱导兔脉络膜新生血管的抑制作用%Inhibitory effect of recombinant human endostatin on choroidal neovascularization in a rabbit model

    Institute of Scientific and Technical Information of China (English)

    赵秀娟; 曲超; 樊映川

    2011-01-01

    epithelium on the seventh day after photocoagulation.But the partial vessel occlusion and fibroplasias were identified in the rh-endostatin injection group in the third week by the OCT.The histopathological examination showed that the morphological abnormality was mild in the rh-endostatin injection group in comparison with model group.The serum PEDF concentration was significantly elevated but the VEGF/PEDF values in vitreous and serum were declined in rhendostatin injection group compared with model group (P < 0.0 1 ).Conclusions Argon laser photocoagulation could induce the experimental CNV in chinchilla rabbit.Intravitreous injection of rh-endostar can effectively inhibit laser-induced CNV in rabbit.

  2. Tratamento cirúrgico da otite média com efusão: tubo de ventilação versus aplicação tópica de mitomicina C Surgical treatment of otitis media with effusion: ventilation tube versus topical application of mitomycin C

    Directory of Open Access Journals (Sweden)

    Celso G. Becker

    2003-08-01

    Full Text Available O uso do tubo de ventilação (TV da orelha média, tratamento cirúrgico eleito da otite média com efusão (OME, não é isento de complicações, promovendo ainda limitação social pela necessidade de abandono dos banhos de imersão. A mitomicina C (MMC é um antineoblástico, cuja aplicação tópica retarda a fibrose e previne a estenose cicatricial. Em cobaias, retardou o fechamento de timpanotomias, permitindo maior tempo de aeração da orelha média, à semelhança dos tubos de ventilação. FORMA DE ESTUDO: Clínico prospectivo. OBJETIVO: Comparar a eficácia entre timpanotomia, aspirado da efusão e inserção de tubo de ventilação (grupo TV versus timpanotomia, aspirado da efusão e aplicação tópica de mitomicina C (grupo MMC. Comparar o tempo de manutenção da timpanotomia e a incidência de complicações nos dois grupos. RESULTADOS: O grupo MMC apresentou eficácia significativamente menor (52% versus 80% que o grupo TV (p= 0,34. A presença de timpanometria tipo "B" e a ausência de comprometimento do óstio faríngeo tubário pelo tecido adenóide no pré-operatório representaram fatores de mau prognóstico. A aplicação tópica de MMC nas bordas da timpanotomia proporcionou um tempo de abertura da membrana timpânica por duas a três semanas. No grupo TV, a otorréia foi observada em 13,3% dos pacientes. No grupo MMC, apesar da menor eficácia, nenhum paciente apresentou complicações nem sofreu prolongada proibição dos banhos de imersão. CONCLUSÃO: Apesar de concluirmos que o TV apresenta maior eficácia, novos estudos utilizando maior concentração, maior tempo de aplicação ou o uso seriado de MMC no tratamento da otite média com efusão devem ser realizados.The insertion of the ventilation tube (VT, which is the surgical treatment for otitis media with effusion (OME, is not free from complications and also limits social life because of the need of abandoning immersion baths. Mitomycin C is an antineoblastic

  3. Wound healing under the effect of iodine cadexomer in rats Cicatrização de feridas sob efeito do cadexômero iodo em ratos

    Directory of Open Access Journals (Sweden)

    Ester Verônica Brustolin

    2012-12-01

    realizado com cadexômero iodo. Os grupos foram divididos em dois subgrupos conforme o dia da morte (7 e 14. Microscopicamente foi utilizada a coloração H&E, através da qual foi observado o processo inflamatório e a neovascularização. Com a coloração tricômio de Masson foi estudada a fibrose. Para o reconhecimento da absorção do iodo e o seu potencial tóxico foi realizado, antes da morte com o animal anestesiado, dosagem do TSH e do T4 livre. RESULTADOS: Na análise microscópica a intensidade da inflamação apresentou-se mais acentuada no grupo GAD, subgrupo 14 dias. Na análise da neovascularização ela apresentou-se discreta no GCS subgrupo 14 dias. Na avaliação da fibrose foi mais acentuada no grupo GCI. Na comparação nos tipos de tratamento houve significância estatística entre os grupos GCI e GCS (p<0,013. A dosagem do TSH e T4, não apresentou diferença entre o grupo controle e GCI em relação à absorção do iodo. Na avaliação dos grupos GCI e controle, dentro de cada tratamento, houve significância estatística entre eles (p<0,001, quando comparados os dias. CONCLUSÃO: O cadexômero iodo apresentou efeito benéfico em todas as fases do processo cicatricial sem citotoxicidade pela absorção do iodo.

  4. Correlación de hallazgos radiológicos con los eventos adversos que posiblemente hayan causado aracnoiditis Correlation between radiological findings and adverse events probably causing arachnoiditis

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    J. A. Aldrete

    2005-07-01

    íces en racimo, deformidades del saco dural y tejido cicatricial y fibrótico en el espacio epidural intervenido quirúrgicamente.Clinical diagnosis of arachnoiditis is characterized by a burning, ardent pain with dysesthesia and vesical, rectal and sexual dysfunction that appear after an adverse event during a spinal surgical procedure; it can be confirmed through magnetic resonance or myelogram followed by lumbar spine tomography. In this study, a retrospective review was conducted of image studies from 436 patients referred to a pain clinic with diagnosis of arachnoiditis in order to identify specific patterns on the radiological images that could help to determine the potential etiology of this disease. The apparent cause was correlated to the appearance of neurological changes after spine injections, interventions or surgical procedures. Neurological deficits were observed in 160 patients after myelograms, rachidian or peridural anesthesia, epidural blood patches or injection of steroids or neurolytic drugs for the management of chronic pain. Eleven (6.8% of these patients had inflammation of roots, 135 (84.3% had roots in bunches and 12 cases (7,5% had roots adhered to the dural sac. Two cases of syringomyelia were observed in patients with thoracal or high lumbar peridural anesthesia. Of 276 other patients in which the clinical diagnosis of arachnoiditis was established after spine surgical procedures, 259 patients (93.8% had roots in bunches, 152 (55% had a deformed dural sac and peridural fibrosis was observed in 241 patients (87.3%. Pseudomeningocele and intrathecal calcifications were observed in 21 (7.6% and 4 (0.15% of the surgical cases, respectively. It is concluded that radiological images in cases of arachnoiditis caused by injections and invasive procedures are only characterized by roots in bunches. However, surgical patients have, in addition to roots in bunches, deformation of the dural sac and healing and fibrotic tissue at the epidural space

  5. Avaliação fitoterápica da Jatropha gossypiifolia L. na cicatrização de suturas na parede abdominal ventral de ratos Phytotherapic evaluation of Jatropha gossypiifolia L. on rats ventral abdominal wall wound healing

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    José Ulcijara Aquino

    2006-01-01

    Full Text Available INTRODUÇÃO: A espécie vegetal Jatropha gossypiifolia L., conhecida também como pião roxo, é utilizada na medicina popular como cicatrizante, anti-hipertensivo, purgativo e diurético. OBJETIVO: Avaliar a influência da administração intraperitoneal da Jatropha gossypiifolia L., na cicatrização de suturas da parede abdominal ventral de ratos, observando-se os seus aspectos macroscópicos, tensiométricos e microscópicos. MÉTODOS: Foram utilizados no procedimento 40 ratos da linhagem Wistar, machos, distribuídos em dois grupos de 20. Após incisão da parede e abertura da cavidade abdominal, foi instilado 1 ml/kg/peso de cloreto de sódio a 0,9% no grupo controle e no grupo Jatropha o extrato bruto etanólico da Jatropha gossypiifolia L., na concentração de 1 ml/kg/ peso. Realizou-se a sutura da parede abdominal com fio de polipropileno, com pontos separados. Os animais foram avaliados na sua evolução pós-operatória e mortos em dois subgrupos, no 3º e 7º dia. Analisou-se a parede abdominal ventral macroscopicamente, mediu-se a força de resistência a tensão e foram estudados os aspectos histológicos do reparo cicatricial. RESULTADOS: No exame macroscópico encontraram-se aderências mais intensas nos subgrupos Jatropha no 3º e 7º dia. A avaliação tensiométrica foi significantemente maior nos subgrupos Jatropha no 3º e 7º dia. A avaliação histológica comparativa entre os subgrupos demonstrou que o processo inflamatório agudo foi significantemente maior no subgrupo Jatropha no 3º e 7º dia; a neoformação capilar foi significantemente maior no 3º dia pós-operatório do subgrupo Jatropha sendo os outros parâmetros histológicos semelhantes. CONCLUSÃO: O uso do extrato bruto de Jatropha gossypiifolia L. intraperitoneal não demonstrou melhora significativa no processo de cicatrização da sutura da parede abdominal ventral de ratos com a dose e concentração utilizadas.INTRODUCTION: The Jatropha gossypiifolia

  6. Hérnias intra-raquidianas dos discos intervertebrais lombares: resultados da excisão em 128 casos

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    Rolando A. Tenuto

    1959-03-01

    ção discai estiver situada no buraco de conjugação, deve ser feita a facetectomia, sendo a intervenção completada com artródese para imobilização. Para a exposição de hérnia discai, a bainha durai da raiz raquidiana deve sempre ser deslocada para a linha mediana, qualquer que seja a situação do prolapso, pois, dêsse modo, são diminuídas as possibilidades de lesões traumáticas da raiz que está sendo manipulada. Fragmentos livres de disco intervertebral no espaço epidural devem ser extirpados; o cirurgião deve ter presente a possibilidade da existência de tais fragmentos em níveis situados imediatamente acima ou abaixo do disco herniado. A rizotomia posterior deve ser praticada quando existir fibrose intensa da bainha durai de raízes raquidianas e, eventualmente, quando a excisão da hérnia discai não fôr julgada satisfatória; a rizotomia posterior deve ser feita, também, tôdas as vêzes em que a reparação de uma lesão acidental da bainha de uma raiz raquidiana não tenha sido satisfatória. A electrocoagulação do ligamento longitudinal posterior, visando à destruição da maior parte do nervo sinuvertebral de Luschka, deve complementar a operação para diminuir a persistência ou a incidência de lombalgias. A hemostasia deve ser perfeita para diminuir a formação de tecido cicatricial, causa de sintomatologia dolorosa no pós-operatório. Com êsse mesmo intuito deve ser interposta lâmina de esponja de gelatina isolando a bainha durai da raiz raquidiana das formações circunvizinhas. Neste trabalho são apresentados os resultados obtidos em 128 casos, escolhidos entre 571 pacientes operados de hérnias intra-raquidianas de discos intervertebrals lombares; êstes 128 casos foram selecionados por terem seguimento de um ano, no mínimo, para permitir boa avaliação dos resultados. Foram considerados como bons tão sòmente os resultados obtidos nos pacientes que, um ano após a intervenção cirúrgica, não apresentavam qualquer sintoma

  7. Análise comparativa da cicatrização da pele com o uso intraperitoneal de extrato aquoso de Orbignya phalerata (babaçu. Estudo controlado em ratos Healing process in cutaneous surgical wounds in rats under the influence of Orbignya phalerata aqueous extract

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    Nelson Lúcio Parada Martins

    2006-01-01

    Full Text Available INTRODUÇÃO: A cicatrização das feridas é processo altamente complexo com várias fases. Inúmeras substâncias têm sido usadas desde os tempos remotos para estimulá-la. Entre elas, o extrato da Orbignya phalerata com possível ação estimulante da cicatrização. OBJETIVO: verificar a ação cicatrizante da Orbignya phalerata na cicatrização das feridas cirúrgicas da pele através de análise comparativa das alterações histológicas e morfológicas. MÉTODOS: Foram utilizados 60 ratos, da linhagem Wistar, adultos e machos. Para o experimento, eles foram distribuídos de forma aleatória em dois grupos de 30 cada e usada a substância Orbignya phalerata intraperitoneal na dose de 50 mg/Kg, no primeiro dia da operação em um dos grupos. O procedimento experimental constituiu-se em incisão cutânea circular de dois centímetros de diâmetro com punch metálico. No grupo controle não foi usada a substância. Os ratos foram mortos nos 7°, 14°, 21° dias do pós-operatório. Realizou-se a análise macroscópica com lupa e paquímetro, para avaliação da evolução do aspecto da lesão cicatricial e morfométrica da ferida feita por análise histológica; as lâminas foram coradas com Hematoxilina-Eosina (HE e tricrômio de Masson e observaram-se a proliferação vascular, células mononucleares, células polimorfonucleares, proliferação fibroblástica, fibras colágenas e reepitelização. RESULTADOS: Mostraram na macroscopia dos animais do grupo experimento de sete dias que um apresentou pequena quantidade de secreção sem outras alterações dignas de nota; nos animais de 14 dias identificou-se todos com ferida de bom aspecto; nos de 21 dias, foi observada a presença de cicatrização completa em todos os animais. Quanto à análise histológica, houve diferença significativa entre os grupos nas variáveis monocelulares e fibras colágenas em todos os dias, e no 7º dia foi observada diferença significativa na prolifera

  8. Tratamiento con acupuntura y moxibustión del síndrome poslaminectomía: Caso clínico Treatment of post-laminectomy syndrome with acupuncture and moxibustion: A clinical case

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    M. Robles Romero

    2010-05-01

    Full Text Available El síndrome de la cirugía fallida de espalda es una complicación frecuente posquirúrgica que cursa con lumbalgia crónica con gran repercusión clínica y económica. Las posibilidades de tratamiento abarcan una gran variedad de técnicas y fármacos, siendo pese a ello una de las principales causas de dolor lumbar de más difícil tratamiento. Cada vez hay más pruebas sólidas de que la acupuntura puede ser un complemento útil al tratamiento convencional para el tratamiento de la lumbalgia. Se presenta el caso de un paciente de 37 años intervenido hace 2 años de artrodesis L4-L5,con reintervención posterior hace 1 año de retirada del material de osteosíntesis persistiendo con síndrome poslaminectomía no controlado con cicatriz disestésica pese a tratamiento con opiáceos débiles y anticonvulsivantes que se trató adecuadamente con sesiones de acupuntura y moxibustión. Como pruebas complementarias tenía una resonancia magnética en la que se aprecian además de cambios postquirúrgicos en la región lumbar posterior, deshidratación discal en L5-S1 y cambios degenerativos artrósicos de las pequeñas articulaciones interapofisarias a nivel de los últimos niveles lumbares, un estudio electroneurofisiológico en el que se observa una alteración en los potenciales evocados somestésicos realizados en el nervio fémorocutáneo lateral izquierdo, compatible con una neuropatía axonal de dicho nervio. El tratamiento se realizó en 10 sesiones durante 5 semanas, en cada una de las sesiones se hizo un tratamiento bifásico de 40min, tratando en primer lugar la zona cicatricial y a continuación la lumbalgia, en ambos se realizó moxibustión con puro de Artemisa con técnica de picoteo. El dolor fue controlándose pasando de una escala EAV inicial de 8 a una escala EAV al final del tratamiento de 0. Tras pasar revisión a los 6 meses continua con una escala EAV de 0.Failed back surgery syndrome is a common post-surgical complication

  9. Utilização de plasma rico em plaquetas para estimulação da angiogênese em flape de padrão axial toracodorsal em coelhos (Oryctolagus cuniculus

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    Josiane M. Pazzini

    2016-02-01

    Full Text Available Resumo: Feridas de grandes extensões, com perda da viabilidade tecidual e retardo na cicatrização por segunda intenção são casos que se faz necessário o emprego de técnicas cirúrgicas reconstrutivas. O plasma rico em plaquetas (PRP é um produto com maior concentração plaquetária, adjuvante no processo cicatricial de cirurgias reconstrutivas, auxiliando nos processos de hemostasia e estimulação da angiogênese. Dessa forma, delineou-se um estudo a fim de avaliar a eficácia do uso do gel produzido a partir do plasma rico em plaquetas (PRP em flapes de avanço de padrão axial toracodorsal em coelhos, para avaliar a possibilidade de favorecer a integração do retalho no leito receptor. Utilizaram-se 30 coelhos da raça Nova Zelândia branco, separados em dois grupos de 15 animais, compreendendo os grupos plasma rico em plaquetas (GPRP, na qual empregou-se o gel antes da síntese da ferida cirúrgica, e controle (GC, na qual utilizou-se apenas solução fisiológica. Para obtenção do PRP, coletou-se sangue dos animais, e determinou-se a contagem plaquetária antes da preparação do gel. No início e término do experimento os animais foram pesados para posterior análise de ganho peso médio. Após o procedimento cirúrgico iniciou-se as avaliações macroscópicas no 3º, 7º e 14º dia, e avaliou-se presença ou ausência de exsudato, integridade da pele, edema, rubor e necrose. Após esta etapa, coletou-se o material da ferida cirúrgica para confecção das lâminas histológicas e posterior avaliação microscópica. Avaliou-se a proliferação vascular, presença de células mononucleares e polimorfonucleares, proliferação fibroblástica, colagenização, reepitelização e hemorragia. Os dados obtidos foram submetidos à análise estatística (Teste t Student, t emparalhado, e Kruskall Walis, sendo p<0,05. O ganho de peso médio não foi significativo entre os grupos; a concentração plaquetária da amostra final do PRP

  10. Análise tensional e morfológica da anastomose colônica na colite induzida por ácido acético a 10%, em ratos Wistar, tratados com extrato aquoso de aroeira-do-sertão a 10% (Myracrodruon urundeuva fr. all. Tensional and morphologic analysis of the colonic anastomosis on 10% acetic acid induced colitis, in Wistar rats, treated with 10% aroeira-do-sertão (Myracrodruon urundeuva fr. all. aqueous extract

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    Antonio Rubens Soares Martins Cavalcante

    2005-04-01

    Full Text Available OBJETIVO: Verificar, do ponto de vista tensional e morfológico, o efeito do extrato aquoso de aroeira-do-sertão a 10% na anastomose colônica, na vigência de colite induzida por ácido acético a 10%, em ratos Wistar. MÉTODOS: Foram utilizados 48 ratos da linhagem Wistar, distribuídos em dois grupos. Todos os animais foram submetidos à indução da colite por solução aquosa de ácido acético a 10%. Vinte e quatro horas após, os animais foram submetidos à laparotomia, colotomia transversa total e anastomose término-terminal com fio de polipropileno 5-0. Grupo A (veículo, animais tratados com veículo à base de carboximetilcelulose. Grupo B (aroeira, animais tratados com extrato aquoso de aroeira a 10%. Ambos tratamentos foram sob a forma de enema. Os grupos A e B foram distribuídos em subgrupos A3, A7, A14 e A21; B3, B7, B14 e B21, respectivamente, conforme a data prevista para a eutanásia (3, 7, 14 e 21 dias. Nas respectivas datas, os animais foram relaparotomizados, o segmento colônico contendo a anastomose foi ressecado, submetido ao teste de pressão e em seguida à análise histológica. Para o estudo morfológico, as lâminas foram coradas com hematoxilina-eosina e avaliou-se a condição de cicatrização baseado numa tabela de escores que variava de 0 a 16. Quanto maior o escore melhor o grau de cicatrização. RESULTADOS: Na avaliação do estudo morfológico, que quantifica a evolução e o grau de cicatrização, como resultado final do processo cicatricial, o grupo aroeira foi superior ao grupo veículo (pPURPOSE: Verify, from a morphologic and tensional view point, the effect of the 10% aqueous extract of aroeira-do-sertão on the colonic anastomosis, during the occurrence of 10% acetic acid induced colitis, in Wistar rats. METHODS: There were used 48 Wistar rats, distributed in two groups. All animals were subjected to induction of colitis by aqueous solution of 10% acetic acid. Twenty-four hours later, the animals

  11. Avaliação do uso do extrato bruto de Jatropha gossypiifolia L. na cicatrização de feridas cutâneas em ratos Evaluation of the use of raw extract of Jatropha gossypiifolia L. in the healing process of skin wounds in rats

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    Manoel Francisco da Silva Santos

    2006-01-01

    Full Text Available INTRODUÇÃO: O uso de fitoterápicos na cicatrização de feridas cirúrgicas tem sido incrementado nos últimos anos com a busca de princípios ativos que desempenhe efetivo papel neste processo acelerando a recuperação cirúrgica. OBJETIVO: Avaliar os aspectos morfológicos do processo cicatricial de feridas cutâneas abertas de ratos com uso do extrato bruto de Jatropha gossypiifolia L. MÉTODOS: Utilizaram-se 60 ratos da linhagem Wistar. Em cada animal foi realizada uma ferida de 2 cm de diâmetro na região dorsal. Os animais foram distribuídos em dois grupos de 30: grupo Controle - sem tratamento e grupo Jatropha - aplicação de extrato bruto de Jatropha gossypiifolia L. Cada grupo foi subdividido em três subgrupos de 10 animais e avaliados no 7º, 14º e 21º dias do pós-operatório. Realizou-se estudo comparativo entre os dois grupos através da análise macroscópica, a planigrafia digital e análise histológica tendo como parâmetro a proliferação vascular, polimorfonucleares, mononucleares, proliferação fibroblástica, colagenização e reepitelização. RESULTADOS: Na evolução da ferida cutânea tanto no grupo controle como no grupo Jatropha houve exsudação plasmática com formação de crostas superficiais até o 7º dia. A partir dai houve espessamento da crosta e no 14º dia a crosta se destacou, evoluindo para tecido de granulação e epitelização completa no 21º dia com surgimento de novos pelos ao redor da lesão, em todos os animais. Houve ausência significativa da inflamação aguda no 21º dia pós-operatório do grupo Jatropha. Houve diferença significativa na intensidade da inflamação crônica, sendo mais intensa no 7º dia no grupo controle. A proliferação fibroblástica foi mais acentuada no 7º dia pós-operatório do grupo Jatropha, sendo semelhante no 14º e 21º dias pós-operatórios nos demais. A colagenização foi maior no 7º e 14º dias no grupo Jatropha. A re-epitelização foi

  12. Effects of circular myotomy on the healing of esophageal suture anastomosis: an experimental study Efeitos da miotomia circular na cicatrização das anastomoses esofágicas: estudo experimental

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    Uenis Tannuri

    1999-02-01

    resultar em fístulas, deiscências ou estenoses devidas à tensão na linha de sutura, principalmente nos casos de grande distância entre os cotos. A miotomia circular do segmento proximal (manobra de Livaditis é a técnica de alongamento esofágico mais utilizada. No presente trabalho experimental, realizado em cães, procurou-se verificar se esta técnica diminui o índice de deiscência de anastomose entre cotos sob grande tensão e estudar se ela promove alterações morfológicas na cicatriz da anastomose. O projeto piloto demonstrou que seria necessário ressecar 40% do esôfago para se obterem índices elevados de deiscência. No projeto experimental, realizou-se tal ressecção, e os cães foram divididos em dois grupos (grupo controle, apenas anastomose, e grupo experimental, anastomose com miotomia circular. Os animais foram mortos no 14º dia de pós-operatório e a seguir submetidos a necropsia, avaliando-se a presença de deiscência e estenose da anastomose. A avaliação microscópica constou de análise histológica qualitativa e histomorfometria da cicatriz da anastomose. Os índices de deiscência foram iguais nos dois grupos. Nos animais do grupo controle a espessura da fibrose e o número de vasos neoformados foram maiores que no grupo experimental. A avaliação morfométrica revelou que a miotomia promoveu diminuição na espessura da fibrose cicatricial. Concluiu-se que a miotomia circular não diminui a possibilidade de deiscência, além de promover alterações deletérias na cicatrização da anastomose.

  13. Avaliação da eficácia da pomada de própolis em portadores de feridas crônicas Evaluación de la eficacia de la pomada de própolis en portadores de heridas crónicas The effect of propolis cream in healing chronic ulcers

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    Marinaldo José dos Santos

    2007-06-01

    Full Text Available OBJETIVO: Avaliar a evolução de úlceras crônicas utilizando a terapêutica tópica com a própolis. MÉTODOS: Trata-se de um estudo descritivo onde foram identificadas vinte pessoas com feridas crônicas encaminhadas pelas Unidades Básicas de Saúde do Município de Maringá, Paraná. A análise baseou-se na avaliação e no tempo de cicatrização das feridas, realizada por meio do cálculo do Coeficiente de Correlação de Pearson para verificar a relação entre as medidas médias horizontais, verticais e de profundidades, a evolução do processo cicatricial. RESULTADOS: O acompanhamento de 22 úlceras crônicas permitiu observar por meio da análise estatística que a chance de cicatrização de todas as lesões foi de 13,1 semanas. Considerando um seguimento de 20 semanas 74,1% das úlceras lograram cicatrização antes desse período. Quanto à etiologia, as úlceras venosas cicatrizaram em 35% (7 dos pacientes, contrapondo-se às úlceras de pressão cuja cicatrização ocorreu em apenas 10,0% (2 dos pacientes. CONCLUSÃO: Concluiu-se, que a utilização da forma farmacêutica pomada de própolis, de fácil acesso e de baixo custo, foi eficiente na cicatrização de feridas.OBJETIVO: Evaluar la evolución de úlceras cronicas utilizando terapéutica tópica con pomada de própolis. MÉTODOS: Se trata de un estudio descriptivo en el cual fueron identificadas veinte personas con heridas crónicas encaminhadas por las Unidades Básicas de Salud del Municipio de Maringá, Paraná- Brasil. El análisis se basó en la evaluación y en el tiempo de cicatrización de las heridas, realizada por medio del cálculo del Coeficiente de Correlación de Pearson para verificar la relación entre las medias horizontales, verticales y de profundidad, o sea, la evolución del proceso de cicatrización. RESULTADOS: El acompañamiento de 22 úlceras crónicas permitió observar, a través del análisis estadístico, que la probabilidad de cicatrizaci

  14. Skin Soft Tissue Expansion Operation Combined with Follicular Unit Extraction Technique in the Treatment of Burn Scar Baldness%皮肤软组织扩张术联合毛囊单位提取技术治疗烧伤后瘢痕性秃发

    Institute of Scientific and Technical Information of China (English)

    丁晓斌; 耿康; 刘洪均; 熊爱兵

    2015-01-01

    Objective To observe the clinical ef ect of extraction technology for the treatment of Burn Scar Baldness after soft tissue expansion application of skin and hair fol icle unit. Methods In our hospital from 2012 March~2014 year in May 98 cases receiving the burn scar alopecia patients, randomly divided into observation group and control group, each 49 cases, observation group of patients with Burn Scar Baldness after application of skin soft tissue expansion operation combined with treatment of fol icular unit extraction technology. The control group of patients with Burn Scar Baldness after application of conventional composite skin graft. Observation of two groups of patients before and after treatment in two groups were recorded respectively, needed for cure time and whether adverse reactions were observed during the treatment. Results The time of cicatricial alopecia patients with skin healing in two groups after burn, the observation group was significantly shorter than the control group, there was significant dif erence, with statistical significance ( <0.05). The total ef iciency of the observation group 95.9%, control group total ef ective rate 77.5%, total ef ective rate of observation group is higher than that of the control group, there was significant dif erence, with statistical significance ( <0.05). The incidence of adverse reactions in 6.1%, the control group adverse reaction rate was 22.4%, the adverse reaction rate of observation group was lower than that of control group were significantly dif erent, with statistical significance ( < 0.05). Conclusion Skin soft tissue expansion operation combined with fol icular unit extraction of significant technique in treating burn scar baldness, significantly improve the healing rate of burn patients, promote the recovery and reconstruction of damaged hair, its clinical advantages of higher, no serious adverse reactions, it is worthy of clinical popularization and application.%目的观察探讨应用皮肤

  15. Ocular Surface Reconstruction: Recent Innovations

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    Madhavan HN

    2009-01-01

    Full Text Available The ocular surface is exceptionally rich in complexity and functionality. Severe ocular surface disorders/conditions, such as chemical or thermal injuries, Stevens-Johnson syndrome (SJS, ocular cicatricial pemphigoid, neurotrophic keratopathy, chronic limbitis, and severe microbial keratitis cause significant morbidities and even corneal blindness. Hypofunction may be caused by Aniridia, Neurotrophy, Endocrine, Pterygium and Chronic limbitis Approximately 6000 patients are seen in Ocular Surface Clinic every year; almost 80% have some form of dry eyes. About 125 new patients of Stevens Johnson Syndrome are seen in a year of which approximately 25% may benefit from Cultured Epithelial Transplant and 75 new patients of thermal/chemical injury in a year of which almost 80% will benefit from Stem Cell Transplantation. Of the 128 severe vernal keratoconjunctivitis which were seen in the ocular surface clinic, 10% require stem cell transplantation. Nearly 30 new cases of Ocular cicatrical pemphigoid every year are seen and they may need stem cell transplantation. In addition, several patients with persistent epithelial defects may benefit from limbal stem cell transplantation to alleviate, maintain conjunctivalization regression and corneal avascularity limbal deficiency, and restore vision. Even if granted that this statistics is for a single large ophthalmic hospital, for a large country as India with 1.1 billion populations, the number of patients requiring corneal stem cell transplantation is enormous. Stem cells in the palisades of Vogt participate in regeneration and preservation of corneal transparency and avascularity. The diminished regenerative capacity seen in LSCD is characterized by persistent epithelial defects, erosion and ulceration, conjunctivalization and neovascularization, and chronic inflammation. Standard corneal transplantation for restoration of corneal clarity and avascularity is a contraindication in the surgical management

  16. Observation on the MRI image and pathology image of the canine model with femoral head avascular necrosis induced by liquid nitrogen frozen%液氮冷冻法诱导犬股骨头缺血性坏死模型MRI影像与病理观察

    Institute of Scientific and Technical Information of China (English)

    朱建龙; 赵红昌

    2011-01-01

    sparse trabecular bone with disordered structure and fragments;bone cells with loose and empty lacunes, karyopyknosis and partly embolismed blood vessel;significantly reduce of hematopoietic tissue in marrow cavity,less cells amounts and looser networks compared with the normal situations, appearance of infiltration with large amount of adipocyte, polymorphocyte and inflammatory cells, increased volume of adipocyte with some merged into bubbly shape.Two months after modeling,the following phenomenon appeared in the femoral head in experimental side as serious destruction of articular surface, disordered and shattered organization structure, abscission and fragmentation of articular cartilage surface, disordered arrangement of cartilage eells, thinner tangential layer, reduced amounts of isogenous chondrocytes, thinner tidal lines under the cartilage, discontinuation between calcified zone and subchondral trabecular bone which formed a shape as inverted stalactite, appearance of medullary cavity formed by osteoclastic bone resorption within cartilage;formation of thrombus in the subchondral vascular;large amount of empty bone lacunas and small amount of scattered bone cells in bone matrix, excursion and pyknosis of nucleus; sparse, thinner and incomplete bone trabecula with microfracture, or shattered and disordered bone trabecula with some merged into laminar shape; existence of scattered osteoclasts, prominent necrosis of myeloid tissue, appearance of fibroplasia repair, hypertrophy of fat cells with some of their left cavities after necrosis and disintegration; appearance of bleeding area in bone marrow, reduced amount of hematopoietic cells, aggregation of large amount of fat cells with some merged into bulla. Conclusion:The canine model with femoral head avascular necrosis induced by liquid nitrogen frozen, which is consistent with the general rule of femur head necrosis and is good in reproducibity,is a kind of ideal model for femoral head avascular necrosis.%

  17. Clinicopathologic features of hepatic diabetic microangiopathy%糖尿病肝微血管病变临床病理学观察

    Institute of Scientific and Technical Information of China (English)

    王征; 何清华; 杨丽; 庞建新; 孙铭君; 于启; 刘冬戈

    2012-01-01

    Objective To study the clinicopathological features of diabetic microangiopathy in liver and diabetic hepatosclerosis (DHS) of elderly male with type 2 diabetes mellitus (T2DM).Methods One hundred and twenty autopsy eases with T2DM (diabetic group) and contemporary 48 cases,non-diabetic and glucose tolerance abnormal,matched by gender and age (control group) were selected in the study.Cases with the cirrhosis and fibrosis of liver caused by other foregone etiological factors were excluded.The histopathological changes of microangiopathy in liver,hepatic portal areas and hepatic sinusoid were investigated by HE staining,histochemical and immunohistochemical stain methods.The clinical data of diagnostic DHS cases were analyzed.Results (1) Microangiopathy was observed in 54.2% (65/120) cases of diabetic group.Histological features:microangiopathy was found in interlobular arteries (especially in arteriole,the lumen diameter < 100 μm),which included endothelial denudation,eosinophilic material deposition in the tunica intima of artery,and eccentric intimal thickening.The smooth muscle fibers of tunica media were hyperplastic or atrophy.Fibroplasia and collagen deposition were found in the tunica adventitia of artery.Arterial lumina showed stenosis and occlusion.Microangiopathy was seen in 16.7% (8/48) cases of the control group.There was statistically significant difference between the two groups (x2 =19.622,P <0.01).(2) The fibrosis and sclerosis of portal areas were detected in 55.8% (67/120) cases of T2DM group.Hyaline collagen fiber tissues was deposited around interlobular arteries,interlobular veins and interlobular bile ducts,resulting in enlargement of the portal area and the secondary atrophy and disappearance of portal triad.The fibrosis and sclerosis of portal areas were detected in 22.9% (11/48)cases of the control group.There was a statistically significant difference between the two groups (x2 =14.936,P <0.01).(3) The pathological features

  18. Experimental basis for antioxidants TA99 series in the treatment of Alzheimer disease%抗氧化剂TA99系列治疗阿尔茨海默病的实验依据

    Institute of Scientific and Technical Information of China (English)

    汪华侨; 范海虹; 徐杰; 李光武; 袁群芳; 谢瑶; 姚志彬

    2005-01-01

    electromicroscope and sulfrin T (Th-T) fluorescence assay, Fuliye-transform infrared(FT-IR) spectrum apparatus, electron magnetic resonance(EPR), and round spectrum were used to detect the inhibitory effect of TA99 series on Aβ gathering and fibroplasia in vitro, as well as the influence on Aβ gathering in vivo. Senescence accelerated mouse (SAM) -P/8 was adopted to establish AD model and behavioral studies such as Morris water maze were used to investigate their effect on learning and memory. Meanwhile, the clearance of intracerebral amyloid granular deposition due to TA99 was also observed with hexamic argent staining. The effects of TA series on Aβ target and possible mechanism were fully revealed, and basic pre-clinical data collection was almost completed.CONCLUSION: TA9901 plant extractions have been proved to inhibit Aβ gathering and fibrosis, and improve learning and memory of SAM-P/8 rats. Moreover, TA9902 prepared by TA9901 combined with EGb761, another synergic herb, has an obvious anti-neurotoxic effect by inhibiting Aβ gathering, fibrosis and secondary structural changes. Further pharmacological research is needed and will have a promising prospect.%目的:目前基础和临床研究已积累的证据支持氧化应激参与阿尔茨海默病的发生和发展有关的学说,应用抗氧化剂治疗可以改善阿尔茨海默病患者的智力功能和延缓随年龄增加的认知丧失.尽管现有抗氧化剂治疗阿尔茨海默病的基础和临床研究资料仍不一致,但大量现有的实验研究资料是有希望并支持继续此项研究.天然抗氧化剂TA99系列的基础药理实验已强烈提示其为一种很有希望的发展成为治疗阿尔茨海默病的新药.文章就目前研究TA9901作为一种有前景的治疗阿尔茨海默病药物的实验依据以及存在的问题进行综述.资料来源:应用计算机检索Medline数据库1991-01/2004-11期间的相关文章,检索词为"Alzheimer disease"和"antioxidants;Ginkgo biloba

  19. Effect of different doses of acyclovir on renal function and its mechanism in mice%不同剂量阿昔洛韦对小鼠肾功能的影响及其机制

    Institute of Scientific and Technical Information of China (English)

    袁堂娟; 许家栋; 谷丽丽; 梁培; 陆红

    2016-01-01

    Objective To explore the effect of different dosage of acyclovir( ACV)on renal function and its mechanism in mice. Methods Thirty ICR mice were divided into the control,ACV 150 μg/ g and 600 μg/ g groups by complete randomization method. Each group comprised 10 mice. The mice in the ACV 150 and 600 μg/ g groups were injected with different dosage of ACV,the control group were injected with same volume of 0. 9% sodium chloride via caudal vein once daily for 7 days. The mice'body weight before the first medication and after the last medication was weighed. The levels of serum creatinine(Scr)and urea nitrogen(BUN)after medication were detected. The mice were sacrificed after collecting the blood samples. The mice kidneys were weighed and the renal coefficient was calculated. One kidney was used for pathologic examinations,and the other was for detection of expression of kidney injury factor-1(KIM-1),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and transforming growth factor-β1( TGF-β1)by immunohistochemical Envision two-step method. The expression score was calculated according to the staining intensity and the percentage of positive cells. Results On day 7 of medication, the body weight of mice in the ACV 150,600 μg/ g groups were lower than that in the control group [(29. 0 ± 0. 59)g,(23. 6 ± 3. 0)g vs.(31. 9 ± 2. 4)g,P < 0. 05,P < 0. 01],the renal coefficient and the levels of BUN and Scr in ACV 600 μg/ g group were higher than those in the control group[(8. 52 ± 0. 77)% vs.(6. 04 ± 0. 71)% ,P < 0. 01;(204 74)μmol/ L vs.(133 ± 30)μmol/ L,P < 0. 01;(13. 8 ± 2. 8)mmol/ L vs. (6. 9 ± 1. 2) mmol/ L,P < 0. 05]. There were renal tubular dilatation and few inflammatory response cell in renal interstitium in the ACV 150 μg/ g group and infiltration of flammatory cells in renal interstitium. There were infiltration of flammatory cells and fibroplasia in renal interstitium and some renal tubular deformation and necrosis in ACV 600 μg/ g group. The

  20. Repair of scars in submaxillary region using expanded forehead axial flaps with fascia pedicles carrying bilateral frontal branches of superficial temporal artery and vein%带双侧颞浅动静脉额支筋膜蒂的额部轴型扩张皮瓣修复下颌部瘢痕

    Institute of Scientific and Technical Information of China (English)

    黄永新; 詹新华; 范金财; 郑静伟; 吴祖煌; 陈建崇; 刘世康

    2010-01-01

    applying expanded forehead axial flaps with fascia pedicles carrying bilateral frontal branches of superficial temporal artery and vein(expanded forehead axial flap with double pedicels in brief, EFAF-DP) in repairing scars in submaxillary region. Methods Sixteen patients with mandibular scars hospitalized in Department of Burns and Plastic Surgery of the First Hospital Affiliated to Fuzhou General Hospital in Nanjing Military Area Command from July 2005 to December 2009 were repaired with EFAF-DP. The operation consisted of 3 stages. Before operation, the location and course of superficial temporal arteries and veins (STAV) and their frontal and parietal branches were identified with Ultrasonic Doppler blood flow detector. In stage Ⅰ , STAV were dissected from the frontalis muscle as a pedicle to form a skin soft tissue space to hold the dilator of a proper size. In stage Ⅱ , after gradual dilation by repeated filling with saline, the dilator was removed. EFAF-DP was dissected to repair mandibular scar. Donor site was closed with sutures. In stage Ⅲ , flap pedicles were divided and pruned. Results Flap sizes ranged from 25 cm ×6 cm to 33 cm × 16 cm. The duration of dilation was 3-5 months, with 3.6 months in average. Ten patients underwent the operation of EFAF-DP transplantation and cervical skin dilatation. All flaps survived with healing of wounds. Disorder of venous return at the distal end of one flap was seen after second stage surgery, and it was corrected after comprehensive treatment including relieving spasm and improving venous return. Donor site wounds healed with normally grown hair without cicatricial alopecia along the hairline. Few hairs grew around mandible in one female patient out of the three(no hair grew on flaps of other two patients). This female patient and two male patients requesting for beard plasty received laser depilation treatment 1 to 3 months after discharge, with good result. Other male patients received no special treatment for

  1. Autoperipheral nerve implantation for the treatment of obsolete incomplete paralysis%自体周围神经植入治疗脊髓陈旧性不完全性断裂伤

    Institute of Scientific and Technical Information of China (English)

    张少成; 马玉海; 许硕贵; 柳顺发; 张秋林; 逄育

    2006-01-01

    several strips and longitudinally implanted into the incised spinal cord and cyst, and then it was sutured with pia mater spinalis with 9-0 scatheless wire. Finally the endorachis was sutured or covered by sacrospinal muscle.RESULTS: Sixteen cases were followed up for an average of 2.5 years, and all the patients entered the result analysis. The sensibility and motion func tion increased above one grade. Eleven patients who had suffered gatism had obvious progress. The strength of main muscle was increased by 2 grades and reached grade 4 in 16 cases, and walking capability was recovered. In 10 cases it was increased by 1 grade Only sensation had progress in 2 cases.CONCLUSION: Relieving adhesion in the endorhachis, incising the cicatricial spinal cord and bridging the autogenous peripheral nerve have good therapeutic results for gatism and recovering the muscle power of the ex-tremities for the patients with traumatic obsolete incomplete paralysis.%背景:临床上常可发现,脊髓损伤患者在排除了脊髓压迫与不稳定等因素外,许多影像学改变极为相似的患者其感觉运动功能的恢复程度差别却很大.研究表明为硬脊膜内的粘连、纤维索条的牵拉、脊髓本身的创伤后瘢痕化、软化、囊肿所致. 目的:观察脊髓减压松解、神经组织植入治疗对陈旧性脊髓不完全性断裂伤的临床效果. ,设计:患者自身前后对照观察.对象:选择1994-06/2002-08解放军第二军医大学长海医院骨科外伤性陈旧性不完全瘫痪患者16例.损伤平面T7~9 5例,T10~12 7例,L1,2 4例.16例患者均曾于伤时行脊柱减压内固定,4例后路手术患者于本次手术前已取出内固定.6例患者曾针对外伤性不完全瘫痪进行过高压氧等治疗.有尿便功能障碍11例;神经根性疼痛4例.按Frankel分级:B级12例,C级4例.单位:解放军第二军医大学长海医院骨科.方法:采用显微外科技术切开患者硬脊膜,将蛛网膜、软脊膜、齿状韧